PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19032679-0 2008 The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. picropodophyllin 52-68 insulin-like growth factor I receptor Mus musculus 4-41 21997878-4 2011 Activation of FGF-ERK1/2 pathway was necessary for the activity of poly(ADP-ribose) polymerase-1 (PARP-1), a conserved nuclear protein catalyzing polymerization of ADP-ribose units. Adenosine Diphosphate 72-75 mitogen-activated protein kinase 3 Homo sapiens 18-24 21997878-4 2011 Activation of FGF-ERK1/2 pathway was necessary for the activity of poly(ADP-ribose) polymerase-1 (PARP-1), a conserved nuclear protein catalyzing polymerization of ADP-ribose units. Adenosine Diphosphate 72-75 poly(ADP-ribose) polymerase 1 Homo sapiens 98-104 21878522-5 2011 Hearts lacking both M-CK and sarcomeric mitochondrial CK have diminished PCr turnover, total phosphotransfer capacity and intracellular energetic communication but increased dynamics of beta-phosphoryls of ADP/ATP, G-6-P and gamma-/beta-phosphoryls of GTP, indicating redistribution of flux through adenylate kinase (AK), glycolytic and guanine nucleotide phosphotransfer circuits. Adenosine Diphosphate 206-209 creatine kinase, muscle Mus musculus 20-24 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 42-45 latexin Homo sapiens 48-51 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 42-45 latexin Homo sapiens 67-70 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 42-45 latexin Homo sapiens 67-70 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 60-63 latexin Homo sapiens 48-51 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 60-63 latexin Homo sapiens 67-70 21919956-7 2011 The strongest correlation was between LTA ADP 5 muM and LTA ADP 20 muM (kappa= 0.53, 95% CI 0.37-0.68); the weakest was between VASP and LTA ADP 5 muM (kappa= 0.33, 95% CI 0.19-0.47). Adenosine Diphosphate 60-63 latexin Homo sapiens 67-70 22130187-7 2011 KIF4 exerts its function in chromatin architecture via regulation of ADP-ribosylation of core and linker histones and by physical interaction and recruitment of chromatin assembly proteins during S-phase. Adenosine Diphosphate 69-72 kinesin family member 4A Homo sapiens 0-4 21896310-0 2011 Prevention of extracellular ADP-induced ATP accumulation of the cultured rat spinal astrocytes via P2Y(1)-mediated inhibition of AMPK. Adenosine Diphosphate 28-31 purinergic receptor P2Y1 Rattus norvegicus 99-105 22000507-2 2011 A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains. Adenosine Diphosphate 148-151 poly(ADP-ribose) glycohydrolase Homo sapiens 71-89 22000507-2 2011 A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains. Adenosine Diphosphate 148-151 poly(ADP-ribose) glycohydrolase Homo sapiens 91-95 21840268-9 2011 These results raise questions and cautions for evaluating PARP inhibitor effectiveness, suggesting whether effects should be considered not only on PARP"s diverse ADP-ribosylation independent protein interactions but also on homologous proteins that may be producing either overlapping or distinct effect. Adenosine Diphosphate 163-166 poly(ADP-ribose) polymerase 1 Homo sapiens 148-152 21974986-8 2011 In several adiponectin receptor-positive cancer cell lines, ADP 355 restricted proliferation in a dose-dependent manner at 100 nM-10 muM concentrations (exceeding the effects of 50 ng/mL globular adiponectin). Adenosine Diphosphate 60-63 adiponectin, C1Q and collagen domain containing Homo sapiens 11-22 21974986-8 2011 In several adiponectin receptor-positive cancer cell lines, ADP 355 restricted proliferation in a dose-dependent manner at 100 nM-10 muM concentrations (exceeding the effects of 50 ng/mL globular adiponectin). Adenosine Diphosphate 60-63 adiponectin, C1Q and collagen domain containing Homo sapiens 196-207 21974986-9 2011 Furthermore, ADP 355 modulated several key signaling pathways (AMPK, Akt, STAT3, ERK1/2) in an adiponectin-like manner. Adenosine Diphosphate 13-16 AKT serine/threonine kinase 1 Homo sapiens 69-72 21974986-9 2011 Furthermore, ADP 355 modulated several key signaling pathways (AMPK, Akt, STAT3, ERK1/2) in an adiponectin-like manner. Adenosine Diphosphate 13-16 signal transducer and activator of transcription 3 Homo sapiens 74-79 21974986-9 2011 Furthermore, ADP 355 modulated several key signaling pathways (AMPK, Akt, STAT3, ERK1/2) in an adiponectin-like manner. Adenosine Diphosphate 13-16 mitogen-activated protein kinase 3 Homo sapiens 81-87 21974986-9 2011 Furthermore, ADP 355 modulated several key signaling pathways (AMPK, Akt, STAT3, ERK1/2) in an adiponectin-like manner. Adenosine Diphosphate 13-16 adiponectin, C1Q and collagen domain containing Homo sapiens 95-106 21974986-10 2011 siRNA knockdown experiments suggested that ADP 355 effects can be transmitted through both adiponectin receptors, with a greater contribution of AdipoR1. Adenosine Diphosphate 43-46 adiponectin, C1Q and collagen domain containing Homo sapiens 91-102 21974986-13 2011 CONCLUSIONS: ADP 355 is a first-in-class adiponectin receptor agonist. Adenosine Diphosphate 13-16 adiponectin, C1Q and collagen domain containing Homo sapiens 41-52 21937914-3 2011 Moreover, PPAR-gamma agonist-treated OLs show increased activity of the mitochondrial respiratory chain Complex IV and an increased ability to respond to environmental signals, such as adenosine diphosphate (ADP), with oscillatory Ca waves; the latter closely correlated with the presence of mitochondria and were inhibited by the mitochondrial respiratory chain Complex I inhibitor rotenone. Adenosine Diphosphate 185-206 peroxisome proliferator activated receptor gamma Homo sapiens 10-20 21937914-3 2011 Moreover, PPAR-gamma agonist-treated OLs show increased activity of the mitochondrial respiratory chain Complex IV and an increased ability to respond to environmental signals, such as adenosine diphosphate (ADP), with oscillatory Ca waves; the latter closely correlated with the presence of mitochondria and were inhibited by the mitochondrial respiratory chain Complex I inhibitor rotenone. Adenosine Diphosphate 208-211 peroxisome proliferator activated receptor gamma Homo sapiens 10-20 21892188-5 2011 We present the first PARG crystal structure (derived from the bacterium Thermomonospora curvata), which reveals that the PARG catalytic domain is a distant member of the ubiquitous ADP-ribose-binding macrodomain family. Adenosine Diphosphate 181-184 poly(ADP-ribose) glycohydrolase Homo sapiens 21-25 21892188-5 2011 We present the first PARG crystal structure (derived from the bacterium Thermomonospora curvata), which reveals that the PARG catalytic domain is a distant member of the ubiquitous ADP-ribose-binding macrodomain family. Adenosine Diphosphate 181-184 poly(ADP-ribose) glycohydrolase Homo sapiens 121-125 21904029-4 2011 In this study, crystal structures of human PDK4 complexed with either AMPPNP, ADP or the inhibitor M77976 were determined. Adenosine Diphosphate 78-81 pyruvate dehydrogenase kinase 4 Homo sapiens 43-47 21904029-5 2011 ADP-bound PDK4 has a slightly wider active-site cleft and a more disordered ATP lid compared with AMPPNP-bound PDK4, although both forms of PDK4 assume open conformations with a wider active-site cleft than that in the closed conformation of the previously reported ADP-bound PDK2 structure. Adenosine Diphosphate 0-3 pyruvate dehydrogenase kinase 4 Homo sapiens 10-14 21904029-5 2011 ADP-bound PDK4 has a slightly wider active-site cleft and a more disordered ATP lid compared with AMPPNP-bound PDK4, although both forms of PDK4 assume open conformations with a wider active-site cleft than that in the closed conformation of the previously reported ADP-bound PDK2 structure. Adenosine Diphosphate 266-269 pyruvate dehydrogenase kinase 4 Homo sapiens 10-14 21904029-5 2011 ADP-bound PDK4 has a slightly wider active-site cleft and a more disordered ATP lid compared with AMPPNP-bound PDK4, although both forms of PDK4 assume open conformations with a wider active-site cleft than that in the closed conformation of the previously reported ADP-bound PDK2 structure. Adenosine Diphosphate 266-269 pyruvate dehydrogenase kinase 4 Homo sapiens 111-115 21904029-5 2011 ADP-bound PDK4 has a slightly wider active-site cleft and a more disordered ATP lid compared with AMPPNP-bound PDK4, although both forms of PDK4 assume open conformations with a wider active-site cleft than that in the closed conformation of the previously reported ADP-bound PDK2 structure. Adenosine Diphosphate 266-269 pyruvate dehydrogenase kinase 4 Homo sapiens 111-115 21933716-5 2011 The structure reveals a dodecamer consisting of two heterohexameric rings with alternating RuvBL1 and RuvBL2 monomers bound to ADP/ATP, that interact with each other via the retained part of domain II. Adenosine Diphosphate 127-130 RuvB like AAA ATPase 1 Homo sapiens 91-97 21803949-10 2011 However, at high extracellular ATP levels, some conversion to ADP may occur and contribute to PAD through P2Y(1) activation. Adenosine Diphosphate 62-65 purinergic receptor P2Y1 Rattus norvegicus 106-112 21812934-1 2011 Poly(ADP-ribose) polymerase-2 (PARP2) belongs to the ADP-ribosyltransferase family of enzymes that catalyze the addition of ADP-ribose units to acceptor proteins, thus affecting many diverse cellular processes. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 2 Homo sapiens 31-36 21675960-2 2011 Sil1 may catalyse the ADP release from Bip by interacting directly with the ATPase domain of Bip. Adenosine Diphosphate 22-25 Sil1p Saccharomyces cerevisiae S288C 0-4 21675960-5 2011 The binding of Sil1 causes the rotation of lobe IIb ~ 13.5 away from the ADP-binding pocket. Adenosine Diphosphate 74-77 Sil1p Saccharomyces cerevisiae S288C 15-19 21564015-2 2011 To help address this issue, we performed two screens on the cancer target, Cdc7-Dbf4 heterodimeric protein kinase, using a direct assay detection method measuring [(33)P]-phosphate incorporation into the substrate and an indirect method measuring residual ADP production using luminescence. Adenosine Diphosphate 256-259 cell division cycle 7 Homo sapiens 75-79 21896310-2 2011 The aim of this study was to observe the effect of P2Y(1) receptor on the abnormal energy metabolism of the cultured rat spinal astrocyte induced by extracellular adenosine diphosphate (ADP). Adenosine Diphosphate 163-184 purinergic receptor P2Y1 Rattus norvegicus 51-57 21896310-2 2011 The aim of this study was to observe the effect of P2Y(1) receptor on the abnormal energy metabolism of the cultured rat spinal astrocyte induced by extracellular adenosine diphosphate (ADP). Adenosine Diphosphate 186-189 purinergic receptor P2Y1 Rattus norvegicus 51-57 21896310-3 2011 The results showed that adenosine triphosphate (ATP) and mitochondrial membrane potential (MMP) in the astrocytes were up-regulated in the presence of ADP, which could be enhanced by MRS2179, a specific antagonist for P2Y(1) receptor. Adenosine Diphosphate 151-154 purinergic receptor P2Y1 Rattus norvegicus 218-224 21896310-6 2011 Our results suggested that the P2Y(1) receptor mediated inhibition of AMPK may help to prevent the astrocytes from over activation induced by extracellular ADP. Adenosine Diphosphate 156-159 purinergic receptor P2Y1 Rattus norvegicus 31-37 21658170-2 2011 The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP AlF(4) (-) reveals characteristic features of eukaryotic TRC40, including a zinc-mediated dimer and a large hydrophobic groove. Adenosine Diphosphate 76-79 guided entry of tail-anchored proteins factor 3, ATPase Homo sapiens 44-49 21658170-2 2011 The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP AlF(4) (-) reveals characteristic features of eukaryotic TRC40, including a zinc-mediated dimer and a large hydrophobic groove. Adenosine Diphosphate 76-79 guided entry of tail-anchored proteins factor 3, ATPase Homo sapiens 137-142 21680740-4 2011 The results reveal that association of Kar3Cik1 with the MT occurs at 4.9 muM(-1) s(-1), followed by a 5-s(-1) structural transition that limits ADP release from the Kar3 head. Adenosine Diphosphate 145-148 Kar3p Saccharomyces cerevisiae S288C 39-43 21792575-5 2011 The latter receptor, the molecular target of the antithrombotic drugs clopidogrel, prasugrel and ticagrelor, is responsible for most of the potentiating effects of ADP when platelets are stimulated by agents such as thrombin, collagen or immune complexes. Adenosine Diphosphate 164-167 coagulation factor II, thrombin Homo sapiens 216-224 21697503-3 2011 Hsc70 binding to CFTR was destabilized by the C-terminal domain of Bag-1 (CBag), which stimulates client release by accelerating ADP-ATP exchange. Adenosine Diphosphate 129-132 CF transmembrane conductance regulator Homo sapiens 17-21 21697503-3 2011 Hsc70 binding to CFTR was destabilized by the C-terminal domain of Bag-1 (CBag), which stimulates client release by accelerating ADP-ATP exchange. Adenosine Diphosphate 129-132 BAG cochaperone 1 Homo sapiens 67-72 21424266-9 2011 The EP(4)-antagonist AE3-208 (1-3 muM) potentiated in combination with PGE(2) (1 muM) ADP-induced aggregation, demonstrating that PGE(2) enhances platelet aggregation when the inhibitory EP(4)-receptor is inactivated. Adenosine Diphosphate 86-89 latexin Homo sapiens 81-84 21680742-2 2011 Our homology models suggest that the mutations (A261T in D45, G200D in Mhc(5)) could stabilize (D45) or destabilize (Mhc(5)) loop 1 of myosin, a region known to influence ADP release. Adenosine Diphosphate 171-174 Myosin heavy chain Drosophila melanogaster 135-141 21680800-4 2011 Activation of human platelets with adenosine diphosphate (ADP) stimulated the release of VEGF, but not endostatin whereas, thromboxane A(2) (TXA(2)) released endostatin but not VEGF. Adenosine Diphosphate 35-56 vascular endothelial growth factor A Homo sapiens 89-93 21680800-4 2011 Activation of human platelets with adenosine diphosphate (ADP) stimulated the release of VEGF, but not endostatin whereas, thromboxane A(2) (TXA(2)) released endostatin but not VEGF. Adenosine Diphosphate 58-61 vascular endothelial growth factor A Homo sapiens 89-93 21377851-8 2011 In vitro, pretreatment with DDKA on washed rat platelets significantly inhibited various agonists stimulated platelet aggregation and caused an increase in cAMP level in platelets activated by ADP. Adenosine Diphosphate 193-196 cathelicidin antimicrobial peptide Rattus norvegicus 156-160 21576651-2 2011 The P2Y(1) receptor for adenosine 5"-diphosphate has been shown to be involved in the development of atherosclerosis in apolipoprotein E--deficient mice. Adenosine Diphosphate 24-48 apolipoprotein E Mus musculus 120-136 21527445-5 2011 METHODS AND RESULTS: In 1524 patients undergoing percutaneous coronary intervention, ADP-induced platelet aggregation was assessed in relation to PON1 Q192R and CYP2C19*2 genotypes. Adenosine Diphosphate 85-88 paraoxonase 1 Homo sapiens 146-150 21781245-3 2011 This process is reinforced by locally produced thrombin and platelet-derived secondary mediators, such as adenosine diphosphate (ADP) and thromboxane A(2) (TxA(2)). Adenosine Diphosphate 106-127 coagulation factor II, thrombin Homo sapiens 47-55 21781245-3 2011 This process is reinforced by locally produced thrombin and platelet-derived secondary mediators, such as adenosine diphosphate (ADP) and thromboxane A(2) (TxA(2)). Adenosine Diphosphate 129-132 coagulation factor II, thrombin Homo sapiens 47-55 21438970-2 2011 We examined the role of intracellular Ca(2+) -independent phospholipase A(2) (iPLA(2)) in the regulation of microglia chemotaxis toward ADP. Adenosine Diphosphate 136-139 phospholipase A2 group VI Homo sapiens 78-85 21391917-6 2011 Finally, we found that the re-sensitization of PAR1 signalling-induced aggregation via PAR4 relied on PKC-mediated release of both ADP from dense granules and fibrinogen from alpha-granules. Adenosine Diphosphate 131-134 coagulation factor II thrombin receptor Homo sapiens 47-51 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 30-51 mitogen-activated protein kinase 14 Homo sapiens 119-122 21530487-7 2011 These effects were associated with a faster kinetic of ADP-induced Erk-2 phosphorylation and were lost in platelets deficient in the IL-17 receptor. Adenosine Diphosphate 55-58 mitogen-activated protein kinase 1 Homo sapiens 67-72 21565702-1 2011 We have determined high-resolution crystal structures of a CDK2/Cyclin A transition state complex bound to ADP, substrate peptide, and MgF(3)(-). Adenosine Diphosphate 107-110 cyclin A2 Homo sapiens 64-72 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 53-56 mitogen-activated protein kinase 14 Homo sapiens 119-122 21373747-7 2011 These results strongly suggest that cAMP regulates ADP-stimulated platelet activation due to inhibition of HSP27 phosphorylation via p38 MAP kinase. Adenosine Diphosphate 51-54 mitogen-activated protein kinase 14 Homo sapiens 133-136 21419681-5 2011 We show that Dicer-2 is a dsRNA-stimulated ATPase that hydrolyzes ATP to ADP; ATP hydrolysis is required for Dicer-2 to process long dsRNA, but not pre-miRNA. Adenosine Diphosphate 73-76 Dicer-2 Drosophila melanogaster 13-20 21251962-0 2011 Decoration of fibrinogen gamma-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets. Adenosine Diphosphate 48-69 fibrinogen gamma chain Homo sapiens 14-36 21288910-6 2011 The binding of AMPPNP or ADP results in a 3-fold increase in the affinity of TraI for ssDNA. Adenosine Diphosphate 25-28 TraI, lipoprotein Escherichia coli 77-81 21317046-7 2011 Indeed we demonstrated that Che-1 protein co-immunoprecipitates with ADP-ribose polymers and that PARP-1 directly interacts with Che-1, promoting its modification in vitro and in vivo. Adenosine Diphosphate 69-72 poly(ADP-ribose) polymerase 1 Homo sapiens 98-104 21251962-6 2011 The 50% inhibition concentration of Fbg on the binding of H12-(ADP)Lipo to platelets was about 25-fold over the concentration of H12 molecules on the liposome. Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 36-39 21232029-8 2011 In the presence of indomethacin and an adenosine 5-diphosphate scavenger, NP-313 concentration-dependently inhibited thrombin- and A23187-induced [Ca(2+)](i) increase through its inhibitory effects on Ca(2+) influx, rather than blocking Ca(2+) release from intracellular stores. Adenosine Diphosphate 39-62 coagulation factor II Mus musculus 117-125 21270334-1 2011 The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory. Adenosine Diphosphate 4-7 poly(ADP-ribose) polymerase 1 Homo sapiens 29-56 21348513-1 2011 The direct observation of a transition state analogue (TSA) complex for tyrosine phosphorylation by a signaling kinase has been achieved using (19)F NMR analysis of MEK6 in complex with tetrafluoroaluminate (AlF(4)(-)), ADP, and p38alpha MAP kinase (acceptor residue: Tyr182). Adenosine Diphosphate 220-223 mitogen-activated protein kinase kinase 6 Homo sapiens 165-169 21348513-1 2011 The direct observation of a transition state analogue (TSA) complex for tyrosine phosphorylation by a signaling kinase has been achieved using (19)F NMR analysis of MEK6 in complex with tetrafluoroaluminate (AlF(4)(-)), ADP, and p38alpha MAP kinase (acceptor residue: Tyr182). Adenosine Diphosphate 220-223 mitogen-activated protein kinase 14 Homo sapiens 229-237 21445350-4 2011 The results suggest the existence of CA3 neuron-selective energy metabolism at the anhydride bonds of ATP and ADP in the hippocampal neurons during seizure. Adenosine Diphosphate 110-113 carbonic anhydrase 3 Mus musculus 37-40 21224467-6 2011 HES1-induced PARP1 activation leads to self-ADP ribosylation of PARP1, consumption of nicotinamide adenine dinucleotide(+), diminished adenosine triphosphate levels, and translocation of apoptosis-inducing factor from mitochondria to the nucleus, resulting in apoptosis in B-ALL but not T-cell ALL. Adenosine Diphosphate 44-47 poly(ADP-ribose) polymerase 1 Homo sapiens 13-18 21224467-6 2011 HES1-induced PARP1 activation leads to self-ADP ribosylation of PARP1, consumption of nicotinamide adenine dinucleotide(+), diminished adenosine triphosphate levels, and translocation of apoptosis-inducing factor from mitochondria to the nucleus, resulting in apoptosis in B-ALL but not T-cell ALL. Adenosine Diphosphate 44-47 poly(ADP-ribose) polymerase 1 Homo sapiens 64-69 21363985-4 2011 Using purified LT, a mutant with reduced ADP-ribosylating activity, and the LT-B subunit alone, we demonstrate that TER reduction requires a functional enterotoxin. Adenosine Diphosphate 41-44 trans-2,3-enoyl-CoA reductase Homo sapiens 116-119 21269340-12 2011 Synaptic activation of mGluRs in the associational-commissural pathway also resulted in persistent depression of the ADP in postsynaptic CA3-PCs, which was blocked by LY367385. Adenosine Diphosphate 117-120 glutamate metabotropic receptor 1 Rattus norvegicus 23-29 21270334-1 2011 The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory. Adenosine Diphosphate 4-7 poly(ADP-ribose) polymerase 1 Homo sapiens 64-68 20875390-5 2011 While in the heart the absence of VDAC3 causes a decrease in the apparent affinity of in situ mitochondria for ADP, in the gastrocnemius, a mixed glycolytic/oxidative muscle, the affinity of in situ mitochondria for ADP remains unchanged. Adenosine Diphosphate 111-114 voltage-dependent anion channel 3 Mus musculus 34-39 21310055-2 2011 Using ratiometric calcium imaging of isolated dorsal root ganglion neurons, we found that the majority of neurons responding to adenosine diphosphate, the preferred endogenous ligand, bound the lectin IB4 and expressed the ATP-gated ion channel P2X3. Adenosine Diphosphate 128-149 purinergic receptor P2X, ligand-gated ion channel, 3 Mus musculus 245-249 21059804-8 2011 The EP3 agonists, 11-deoxy-16,16-dimethyl PGE(2) (11d-16dm PGE(2)) and sulprostone enhanced the secondary wave of ADP-induced aggregation, with EC(50) of 48.6 +- 10 nM (E(max), 252 +- 51%) and 5 +- 2 nM (E(max), 300 +- 35%), respectively. Adenosine Diphosphate 114-117 prostaglandin E receptor 3 Homo sapiens 4-7 21081493-7 2011 Moreover, HDAC 2 and 3 are released from the promoter with an IL-4 signal, this is aided by the ADP-ribosylation of the HDACs by PARP-14. Adenosine Diphosphate 96-99 histone deacetylase 2 Homo sapiens 10-22 21081493-7 2011 Moreover, HDAC 2 and 3 are released from the promoter with an IL-4 signal, this is aided by the ADP-ribosylation of the HDACs by PARP-14. Adenosine Diphosphate 96-99 interleukin 4 Homo sapiens 62-66 21261390-0 2011 Dynamic coupling between the LID and NMP domain motions in the catalytic conversion of ATP and AMP to ADP by adenylate kinase. Adenosine Diphosphate 102-105 adenosine kinase Homo sapiens 109-125 21261390-1 2011 The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. Adenosine Diphosphate 94-115 adenosine kinase Homo sapiens 125-141 21261390-1 2011 The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. Adenosine Diphosphate 94-115 adenosine kinase Homo sapiens 143-146 21261390-1 2011 The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. Adenosine Diphosphate 117-120 adenosine kinase Homo sapiens 125-141 21261390-1 2011 The catalytic conversion of adenosine triphosphate (ATP) and adenosine monophosphate (AMP) to adenosine diphosphate (ADP) by adenylate kinase (ADK) involves large amplitude, ligand induced domain motions, involving the opening and the closing of ATP binding domain (LID) and AMP binding domain (NMP) domains, during the repeated catalytic cycle. Adenosine Diphosphate 117-120 adenosine kinase Homo sapiens 143-146 21035462-3 2011 Based on this new structure, we reanalyzed electron microscopy reconstructions of UvsX-DNA filaments and docked the UvsX crystal structure into two different filament forms: a compressed filament generated in the presence of ADP and an elongated filament generated in the presence of ATP and aluminum fluoride. Adenosine Diphosphate 225-228 recombinase RecA Escherichia phage T4 116-120 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Adenosine Diphosphate 68-71 coagulation factor II, thrombin Homo sapiens 212-220 21697640-2 2011 Deficiency of cellular nicotinamide adenine dinucleotide (NAD(+)) content, consumed by PARP-1 to add ADP-ribose moieties onto target proteins, contributes to pathophysiological conditions. Adenosine Diphosphate 101-104 poly(ADP-ribose) polymerase 1 Homo sapiens 87-93 21602602-4 2011 Furthermore, m(r)CRP (100 mug/ml) strongly augmented spontaneous and ADP-induced fibrinogen binding to platelets (p < 0.05), platelet adhesion to fibrinogen and platelet aggregation. Adenosine Diphosphate 69-72 C-reactive protein Homo sapiens 17-20 21602602-4 2011 Furthermore, m(r)CRP (100 mug/ml) strongly augmented spontaneous and ADP-induced fibrinogen binding to platelets (p < 0.05), platelet adhesion to fibrinogen and platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 81-91 21602602-4 2011 Furthermore, m(r)CRP (100 mug/ml) strongly augmented spontaneous and ADP-induced fibrinogen binding to platelets (p < 0.05), platelet adhesion to fibrinogen and platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 149-159 21870258-2 2011 PARP catalyzes the addition of ADP-ribose molecules (pADPr) to the target proteins, a process termed poly-ADP-ribosylation. Adenosine Diphosphate 31-34 poly(ADP-ribose) polymerase 1 Homo sapiens 0-4 21870266-1 2011 Poly (ADP-ribosyl)ation of proteins is a posttranslational modification mediated by poly (ADP-ribose) polymerases (PARPs) that uses NAD(+) as substrate to form the negatively charged polymer of poly (ADP-ribose) (PAR). Adenosine Diphosphate 6-9 poly(ADP-ribose) polymerase 1 Homo sapiens 115-120 20978083-2 2011 The u-ATP9 transgene driven by A9 and APETALA3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and adenine nucleotides (ATP, ADP) levels without changes in the ATP/ADP ratio. Adenosine Diphosphate 165-168 ATPase subunit 9 Arabidopsis thaliana 6-10 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Adenosine Diphosphate 229-232 fibrinogen beta chain Homo sapiens 170-180 21388249-7 2011 When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor. Adenosine Diphosphate 229-232 coagulation factor II, thrombin Homo sapiens 212-220 21935367-2 2011 On hepatocytes, apoA-I binds to cell surface ATP synthase (namely ecto-F(1)-ATPase) and stimulates its ATPase activity, generating extracellular ADP. Adenosine Diphosphate 145-148 apolipoprotein A1 Homo sapiens 16-22 22073153-4 2011 PRINCIPAL FINDINGS: Incubation of human platelets with insulin or alpha-PGG induced phosphorylation of insulin receptors and IRS-1 and blocked ADP or collagen induced aggregation. Adenosine Diphosphate 143-146 insulin Homo sapiens 55-62 22073128-8 2011 Poly(ADP-ribosy)lation enhanced Smad-Smad binding element (SBE) complex formation in nuclear extracts and increased DNA binding activity of Smad3. Adenosine Diphosphate 4-8 SMAD family member 3 Rattus norvegicus 140-145 20797426-5 2010 The flow method introduced here was employed to determine the effect of Tbeta(4), on the deposition of ADP-activated platelets onto fibrinogen cross-linked flow chambers. Adenosine Diphosphate 103-106 thymosin beta 4 X-linked Homo sapiens 72-80 21134286-6 2010 RESULTS: NSC23766 (300 muM) inhibited TRAP-, collagen-, atherosclerotic plaque-, and ADP-induced platelet aggregation in blood by 95.1%, 93.4%, 92.6%, and 70%, respectively. Adenosine Diphosphate 85-88 latexin Homo sapiens 23-26 20797426-5 2010 The flow method introduced here was employed to determine the effect of Tbeta(4), on the deposition of ADP-activated platelets onto fibrinogen cross-linked flow chambers. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 132-142 20975043-2 2010 Nicotinamide adenine dinucleotide (NAD(+)) released during cell damage or inflammation results in ART2.2-mediated ADP-ribosylation of the cytolytic P2X7 receptor on T cells. Adenosine Diphosphate 114-117 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 148-161 20838744-6 2010 The primary outcome measure of this retrospective study was the ADP-induced platelet aggregation in patients with versus those without elevated CRP levels. Adenosine Diphosphate 64-67 C-reactive protein Homo sapiens 144-147 21105189-6 2010 TNF-alpha/CCK also enhanced caspases" activity and lactate dehydrogenase release, induced ATP loss, and augmented the ADP/ATP ratio. Adenosine Diphosphate 118-121 tumor necrosis factor Rattus norvegicus 0-9 21095583-5 2010 PARP-1 dissociates Smad complexes from DNA by ADP-ribosylating Smad3 and Smad4, which attenuates Smad-specific gene responses and TGF-beta-induced epithelial-mesenchymal transition. Adenosine Diphosphate 46-49 poly(ADP-ribose) polymerase 1 Homo sapiens 0-6 20813187-6 2010 ADP-induced intracellular calcium mobilization was blocked by phospholipase C inhibitor U73122 and by P2Y(1) receptor-selective antagonist MRS2500, but not by pertussis toxin (PTX), suggesting a mechanism mediated by the G(q)-coupled P2Y(1) receptor, but not P2Y(13) (G(i)-coupled) or P2X receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Rattus norvegicus 102-108 20813187-6 2010 ADP-induced intracellular calcium mobilization was blocked by phospholipase C inhibitor U73122 and by P2Y(1) receptor-selective antagonist MRS2500, but not by pertussis toxin (PTX), suggesting a mechanism mediated by the G(q)-coupled P2Y(1) receptor, but not P2Y(13) (G(i)-coupled) or P2X receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Rattus norvegicus 234-240 20813187-9 2010 Thus, we demonstrated that ADP-mediated intracellular calcium mobilization and Hex release in RBL-2H3 cells are via P2Y(1) and P2Y(13) receptors, respectively. Adenosine Diphosphate 27-30 purinergic receptor P2Y1 Rattus norvegicus 116-122 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 51-54 poly(ADP-ribose) polymerase 1 Homo sapiens 91-96 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 51-54 macroH2A.1 histone Homo sapiens 149-160 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 121-124 poly(ADP-ribose) polymerase 1 Homo sapiens 91-96 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 121-124 macroH2A.1 histone Homo sapiens 149-160 20728084-8 2010 Levels of IL-6, RANTES, and CRP correlated well with ADP and arachidonic acid (AA)-induced MEA. Adenosine Diphosphate 53-56 interleukin 6 Homo sapiens 10-14 20728084-8 2010 Levels of IL-6, RANTES, and CRP correlated well with ADP and arachidonic acid (AA)-induced MEA. Adenosine Diphosphate 53-56 C-reactive protein Homo sapiens 28-31 20960209-6 2010 ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide). Adenosine Diphosphate 0-3 signal transducer and activator of transcription 3 Mus musculus 107-112 20960209-6 2010 ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide). Adenosine Diphosphate 0-3 signal transducer and activator of transcription 3 Mus musculus 114-122 21151460-7 2010 Real-time quantitative PCR and whole-mount in situ hybridization analysis revealed that P-selectin was expressed in early embryonic development, the expression increased from 0.2 hpf (1-cell stage) to 72 hpf, and the expression significantly upregulated within 30 minutes of ADP induction. Adenosine Diphosphate 275-278 selectin P Danio rerio 88-98 20652632-4 2010 ADP or ATP also prevented Ca(2+)-induced mitochondrial swelling and cytochrome c release. Adenosine Diphosphate 0-3 cytochrome c, somatic Homo sapiens 68-80 20719931-16 2010 Both the ADP and greater depolarizing input resistance likely contribute to increased excitability of PVN-RVLM neurons from rats with AngII-Salt hypertension. Adenosine Diphosphate 9-12 angiotensinogen Rattus norvegicus 134-139 21331307-0 2010 COX-2 Inhibition by Use of Rofecoxib or High Dose Aspirin Enhances ADP-Induced Platelet Aggregation in Fresh Blood. Adenosine Diphosphate 67-70 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-5 21331307-9 2010 CONCLUSIONS: We conclude that both selective and nonselective COX-2 inhibition enhances ADP-induced platelet aggregation in humans. Adenosine Diphosphate 88-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 62-67 20942953-1 2010 BACKGROUND: The poly(ADP-ribose) polymerase (PARP) superfamily was originally identified as enzymes that catalyze the attachment of ADP-ribose subunits to target proteins using NAD+ as a substrate. Adenosine Diphosphate 21-24 poly(ADP-ribose) polymerase 1 Homo sapiens 45-49 20542106-9 2010 An increase in cyclin D1 expression, that could be inhibited by 10 microM LY 294002 or 20 microM U0126, was observed when cells were incubated with 500 microM ADP. Adenosine Diphosphate 159-162 cyclin D1 Gallus gallus 15-24 20681951-0 2010 TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. Adenosine Diphosphate 26-29 transforming growth factor beta 1 Homo sapiens 0-8 20681951-5 2010 Then, we found that migratory capability and expression of both P2Y receptors were abrogated in microglial cells from LPS-stimulated mixed glial cultures, while TGF-beta increased ADP-induced migration and the expression of P2Y12 and P2Y1 receptors. Adenosine Diphosphate 180-183 transforming growth factor beta 1 Homo sapiens 161-169 20679351-6 2010 Currents were abolished by P2Y(1) antagonists and by blockade of phospholipase C. ADP also caused rises in intracellular Ca(2+), and ADP-evoked currents were abolished when inositol trisphosphate-sensitive Ca(2+) stores were depleted. Adenosine Diphosphate 82-85 purinergic receptor P2Y1 Rattus norvegicus 27-33 20679351-6 2010 Currents were abolished by P2Y(1) antagonists and by blockade of phospholipase C. ADP also caused rises in intracellular Ca(2+), and ADP-evoked currents were abolished when inositol trisphosphate-sensitive Ca(2+) stores were depleted. Adenosine Diphosphate 133-136 purinergic receptor P2Y1 Rattus norvegicus 27-33 20679351-8 2010 In hippocampal neurons, ADP also triggered outward currents at 30 mV which were attenuated by P2Y(1) antagonists, depletion of Ca(2+) stores, or a blocker of K(Ca)2 channels. Adenosine Diphosphate 24-27 purinergic receptor P2Y1 Rattus norvegicus 94-100 20664890-7 2010 AE1-329 also inhibited adenosine diphosphate-induced platelet aggregation, and the inhibition was almost completely blocked by AE3-208, an EP4 antagonist. Adenosine Diphosphate 23-44 solute carrier family 4 (anion exchanger), member 1 Mus musculus 0-3 20525793-1 2010 The chromatin-associated enzyme PARP1 has previously been suggested to ADP-ribosylate histones, but the specific ADP-ribose acceptor sites have remained enigmatic. Adenosine Diphosphate 71-74 poly(ADP-ribose) polymerase 1 Homo sapiens 32-37 20525793-4 2010 Multiple explicit water molecular dynamics simulations of the H4 tail peptide into the catalytic cleft of PARP1 indicate that two stable intermolecular salt bridges hold the peptide in an orientation that allows K16 ADP-ribosylation. Adenosine Diphosphate 216-219 poly(ADP-ribose) polymerase 1 Homo sapiens 106-111 20525793-5 2010 Consistent with a functional cross-talk between ADP-ribosylation and other histone tail modifications, acetylation of H4K16 inhibits ADP-ribosylation by PARP1. Adenosine Diphosphate 48-51 poly(ADP-ribose) polymerase 1 Homo sapiens 153-158 20525793-5 2010 Consistent with a functional cross-talk between ADP-ribosylation and other histone tail modifications, acetylation of H4K16 inhibits ADP-ribosylation by PARP1. Adenosine Diphosphate 133-136 poly(ADP-ribose) polymerase 1 Homo sapiens 153-158 20451958-5 2010 RESULTS: In comparison to control Apoe-/- mice exposed to filtered ambient air, smoke-exposed Apoe-/- mice displayed a 1.8+-0.3 fold enhanced ADP-induced fibrinogen binding ex vivo (P<0.001) and had a shorter time to thrombotic occlusion following ferric chloride injury of the carotid artery (median time to thrombosis of 8 vs. 13 min; P=0.015). Adenosine Diphosphate 142-145 apolipoprotein E Mus musculus 94-98 20718861-7 2010 In an in vitro assay, intact ETA induced ADP-ribosylation of EF-2 and mitochondrial release of cytochrome c, with the former effect being efficiently increased by a cathepsin B/cathepsin D pretreatment. Adenosine Diphosphate 41-44 eukaryotic translation elongation factor 2 Rattus norvegicus 61-65 20816067-10 2010 Our modeling suggests the converter domain is responsible for the difference in rate-limiting cross-bridge steps between EMB and IFI myosin--i.e., a myosin isomerization associated with MgADP release for EMB and Pi release for IFI. Adenosine Diphosphate 186-191 Myosin heavy chain Drosophila melanogaster 133-139 20816067-10 2010 Our modeling suggests the converter domain is responsible for the difference in rate-limiting cross-bridge steps between EMB and IFI myosin--i.e., a myosin isomerization associated with MgADP release for EMB and Pi release for IFI. Adenosine Diphosphate 186-191 Myosin heavy chain Drosophila melanogaster 149-155 20600569-4 2010 It was observed that acetoxy derivatives of benzofurans lead to inhibition of ADP induced platelet aggregation by the activation of platelet Nitric Oxide Synthase catalyzed by CRTAase. Adenosine Diphosphate 78-81 nitric oxide synthase 2 Homo sapiens 141-162 20797535-4 2010 ADP passage through the outer membrane is diminished in spinal mitochondria from mutant SOD1-expressing ALS rats. Adenosine Diphosphate 0-3 superoxide dismutase 1 Rattus norvegicus 88-92 20679690-1 2010 Poly(ADP-ribose)polymerase-1 (PARP-1) catalyzes the polymerization of ADP-ribose units from NAD+ modules on target proteins, resulting in the attachment of linear or branched polymers. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 30-36 20664064-2 2010 Here, we show that macrophages navigate in a gradient of the chemoattractant C5a through the release of adenosine triphosphate (ATP) and autocrine "purinergic feedback loops" that involve receptors for ATP (P2Y(2)), adenosine diphosphate (ADP) (P2Y(12)), and adenosine (A2a, A2b, and A3). Adenosine Diphosphate 216-237 hemolytic complement Mus musculus 77-80 20664064-2 2010 Here, we show that macrophages navigate in a gradient of the chemoattractant C5a through the release of adenosine triphosphate (ATP) and autocrine "purinergic feedback loops" that involve receptors for ATP (P2Y(2)), adenosine diphosphate (ADP) (P2Y(12)), and adenosine (A2a, A2b, and A3). Adenosine Diphosphate 239-242 hemolytic complement Mus musculus 77-80 20441566-5 2010 Our results show that loss of the PI3K signal impaired the ability of ADP to induce platelet aggregation, ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 70-73 mitogen-activated protein kinase 1 Homo sapiens 106-109 20441566-10 2010 Moreover, PI3Kbeta mediates ADP-induced thromboxane A2 generation by regulating ERK phosphorylation. Adenosine Diphosphate 28-31 mitogen-activated protein kinase 1 Homo sapiens 80-83 20624795-8 2010 These changes in kinetic behaviour can be explained by a caveolin-induced shift in the channel"s sensitivity to its physiological regulator MgADP. Adenosine Diphosphate 140-145 caveolin 1 Homo sapiens 57-65 20060508-4 2010 SIRT4 can transfer the ADP-ribose group from NAD(+) onto acceptor proteins. Adenosine Diphosphate 23-26 sirtuin 4 Homo sapiens 0-5 20447456-2 2010 In this study, we demonstrate that both ADP and its stable analogue 2-methyl-thio-ADP (2MeSADP) induce up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1). Adenosine Diphosphate 40-43 heme oxygenase 1 Mus musculus 147-163 20447456-2 2010 In this study, we demonstrate that both ADP and its stable analogue 2-methyl-thio-ADP (2MeSADP) induce up-regulation of the cytoprotective protein heme oxygenase-1 (HO-1). Adenosine Diphosphate 40-43 heme oxygenase 1 Mus musculus 165-169 20546121-5 2010 Human Gas6 synergizes with ADP-P2Y(12) by enhancing and prolonging the phosphorylation of Akt. Adenosine Diphosphate 27-30 AKT serine/threonine kinase 1 Homo sapiens 90-93 20540954-5 2010 The ADP/O ratio, the mitochondrial membrane potential, the matrix NAD(P)H levels and aconitase activity were also diminished by cis-4-decenoic acid. Adenosine Diphosphate 4-7 suppressor of cytokine signaling 6 Homo sapiens 128-133 20450878-3 2010 Akt phosphorylation in response to nucleotides followed the potency order ATP=UTP=ATPgammaS>>ADP=UDP>ADPbetaS=adenosine, suggesting participation of P2Y(2/4) receptors. Adenosine Diphosphate 99-102 AKT serine/threonine kinase 1 Homo sapiens 0-3 20718861-7 2010 In an in vitro assay, intact ETA induced ADP-ribosylation of EF-2 and mitochondrial release of cytochrome c, with the former effect being efficiently increased by a cathepsin B/cathepsin D pretreatment. Adenosine Diphosphate 41-44 cathepsin D Rattus norvegicus 177-188 20361728-0 2010 Phosphorylation of the transcription factor Ets-1 by ERK2: rapid dissociation of ADP and phospho-Ets-1. Adenosine Diphosphate 81-84 mitogen-activated protein kinase 1 Homo sapiens 53-57 20421285-8 2010 Consistent with this finding, apical secretions from PAR-stimulated cells contained relatively high levels of ADP/AMP, which could not be accounted for solely based on ATP release and hydrolysis. Adenosine Diphosphate 110-113 nuclear receptor subfamily 1 group I member 2 Homo sapiens 53-56 20303835-6 2010 This association was necessary to regulate PARP-1 activity since poly(ADP-ribosylation) induced by DNA damage was higher in p21(-/-) human fibroblasts than in parental p21(+/+) cells, and in primary fibroblasts after p21 knock-down by RNA interference. Adenosine Diphosphate 70-73 poly(ADP-ribose) polymerase 1 Homo sapiens 43-49 20303835-6 2010 This association was necessary to regulate PARP-1 activity since poly(ADP-ribosylation) induced by DNA damage was higher in p21(-/-) human fibroblasts than in parental p21(+/+) cells, and in primary fibroblasts after p21 knock-down by RNA interference. Adenosine Diphosphate 70-73 cyclin dependent kinase inhibitor 1A Homo sapiens 124-127 20447827-2 2010 In this communication, we have reported for the first time that acetoxy quinolones are endowed with antiplatelet action by virtue of causing CRTAase catalyzed activation of platelet Nitric Oxide Synthase (NOS) by way of acetylation leading to the inhibition of ADP/Arachidonic acid (AA)-dependent platelet aggregation. Adenosine Diphosphate 261-264 nitric oxide synthase 2 Homo sapiens 182-203 20345719-4 2010 It reduced ADP-enhanced platelet P-selectin expression and fibrinogen binding, which consequently hampered ADP-induced platelet-leukocyte aggregation. Adenosine Diphosphate 11-14 selectin, platelet Mus musculus 33-43 20345719-4 2010 It reduced ADP-enhanced platelet P-selectin expression and fibrinogen binding, which consequently hampered ADP-induced platelet-leukocyte aggregation. Adenosine Diphosphate 107-110 selectin, platelet Mus musculus 33-43 20439749-0 2010 Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response. Adenosine Diphosphate 32-35 aprataxin and PNKP like factor Homo sapiens 65-69 20439749-6 2010 Basic residues (R387 and R429 in the first and second PBZ domains, respectively) coordinate additional interactions with the phosphate backbone of ADP-ribose, suggesting that APLF binds to multiple ADP-ribose residues along PAR polymers. Adenosine Diphosphate 147-150 aprataxin and PNKP like factor Homo sapiens 175-179 20361728-3 2010 A feature of the mechanism in the forward direction is a partially rate-limiting product release step (koff = 59 +/- 6 s(-1)), which is significant because to approach maximum efficiency substrates for ERK2 may evolve to ensure that ADP dissociation is rate-limiting. Adenosine Diphosphate 233-236 mitogen-activated protein kinase 1 Homo sapiens 202-206 20361728-8 2010 A catalytic trapping approach furnished a rate constant (k-ADPa) of 61 +/- 12 s(-1) for the dissociation of ADP from the abortive ternary complex, ERK2.Ets.ADP. Adenosine Diphosphate 59-62 mitogen-activated protein kinase 1 Homo sapiens 147-151 20361728-8 2010 A catalytic trapping approach furnished a rate constant (k-ADPa) of 61 +/- 12 s(-1) for the dissociation of ADP from the abortive ternary complex, ERK2.Ets.ADP. Adenosine Diphosphate 108-111 mitogen-activated protein kinase 1 Homo sapiens 147-151 20361728-12 2010 These data suggest that koff may be limited by the dissociation of both products and are consistent with the notion that Ets-1 has evolved to be an efficient substrate for ERK2, where ADP release is, at least, partially rate-limiting. Adenosine Diphosphate 184-187 mitogen-activated protein kinase 1 Homo sapiens 172-176 20189992-6 2010 Inhibitory effect of PP2 on platelet aggregation induced by thrombin and thromboxane A(2) were also reversed by supplementing ADP. Adenosine Diphosphate 126-129 coagulation factor II, thrombin Homo sapiens 60-68 20154214-4 2010 The role of ADP and TxA(2) in mediating phosphorylation is dependent on ligand engagement and rac activation but is independent of platelet aggregation. Adenosine Diphosphate 12-15 AKT serine/threonine kinase 1 Homo sapiens 94-97 20089714-9 2010 We also found that phosphorylation of the myosin RLC increases actomyosin affinity for ADP, suggesting a kinetic role for RLC phosphorylation. Adenosine Diphosphate 87-90 myosin light chain 12A Homo sapiens 42-52 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 0-21 integrin subunit beta 3 Homo sapiens 103-109 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 0-21 fibrinogen beta chain Homo sapiens 127-137 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 23-26 integrin subunit beta 3 Homo sapiens 103-109 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 127-137 20097289-3 2010 In cells coexpressing the Galpha(i)-coupled hP2Y(12) receptor, ADP and ATP significantly inhibited hK(2P)2.1 currents. Adenosine Diphosphate 63-66 potassium two pore domain channel subfamily K member 2 Homo sapiens 99-108 20097289-5 2010 In cells coexpressing the Galpha(q/11)-coupled hP2Y(1) receptor, ADP and ATP also inhibited hK(2P)2.1 currents, which were abolished by MRS2179, but unaffected by AR-C69931MX and PTX. Adenosine Diphosphate 65-68 potassium two pore domain channel subfamily K member 2 Homo sapiens 92-101 20097289-6 2010 When both receptors were coexpressed with K(2P)2.1 channels, ADP-induced inhibition was antagonised by AR-C69913MX and MRS2179, but not PTX. Adenosine Diphosphate 61-64 potassium two pore domain channel subfamily K member 2 Homo sapiens 42-50 20172594-7 2010 However, ADP-, botrocetin-, and alpha-thrombin-induced platelet aggregation, platelet adhesion and spreading on von Willebrand factor surface were significantly reduced in platelets pre-treated with CaM antagonists. Adenosine Diphosphate 9-12 coagulation factor II, thrombin Homo sapiens 38-46 20172594-7 2010 However, ADP-, botrocetin-, and alpha-thrombin-induced platelet aggregation, platelet adhesion and spreading on von Willebrand factor surface were significantly reduced in platelets pre-treated with CaM antagonists. Adenosine Diphosphate 9-12 calmodulin 1 Homo sapiens 199-202 20036271-9 2010 Poly(ADP-ribosyl)ation of P53 is reported to block its activation, DNA binding and its functioning as a transcription factor. Adenosine Diphosphate 5-8 tumor protein p53 Homo sapiens 26-29 20197504-12 2010 Platelet aggregatory response to epinephrine and ADP significantly decreased following preincubation with adiponectin (96 +/- 4 vs. 23 +/- 3%, P < 0.001, and 102 +/- 9 vs. 85 +/- 9%, P = 0.004). Adenosine Diphosphate 49-52 adiponectin, C1Q and collagen domain containing Homo sapiens 106-117 19948081-2 2010 Several pyruvate-dependent and -independent shuttles enhance tricarboxylic acid cycle intermediate (TACI) anaplerosis and increase beta-cell ATP:ADP ratio, triggering insulin exocytotic mechanisms. Adenosine Diphosphate 145-148 insulin Homo sapiens 167-174 19948081-9 2010 Furthermore, insulin release is tightly coupled to ATP:ADP rise which in turn is related to TACI anaplerosis. Adenosine Diphosphate 55-58 insulin Homo sapiens 13-20 20352154-7 2010 Adjusted mean ADP-induced on-clopidogrel platelet reactivity was significantly higher in both users of Pgp-inhibiting CCBs and amlodipine as compared to CCB non-users (all p<0.05). Adenosine Diphosphate 14-17 ATP binding cassette subfamily B member 1 Homo sapiens 103-106 20189992-5 2010 The inhibitory effect of Lyn knock-out on platelet aggregation was reversed by supplementing granule content ADP, indicating that the primary role of Lyn is to stimulate granule secretion. Adenosine Diphosphate 109-112 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 25-28 19836035-3 2010 HSP70 purification was carried out by immunoaffinity chromatography using adenosine di-phosphate (ADP-agarose column) and the characterization of the purified protein was done using western blotting by mouse monoclonal anti-HSP70. Adenosine Diphosphate 74-96 heat shock 70 kDa protein 1B Bos taurus 0-5 19836035-3 2010 HSP70 purification was carried out by immunoaffinity chromatography using adenosine di-phosphate (ADP-agarose column) and the characterization of the purified protein was done using western blotting by mouse monoclonal anti-HSP70. Adenosine Diphosphate 98-101 heat shock 70 kDa protein 1B Bos taurus 0-5 20223214-7 2010 In fact, BD5 reduced the affinity of the NBD for ADP. Adenosine Diphosphate 49-52 defensin beta 105A Homo sapiens 9-12 20079708-5 2010 However, previous PARG assay systems are not appropriate for high-throughput screening because PARG activity is measured by radioactivities of ADP-ribose residues released from radioisotope (RI)-labeled poly(ADP-ribose). Adenosine Diphosphate 143-146 poly(ADP-ribose) glycohydrolase Homo sapiens 95-99 19846210-6 2010 Platelet reactivity was determined by ADP-induced P-selectin expression, aggregation and adhesion on fibrinogen coated membranes under arterial flow conditions. Adenosine Diphosphate 38-41 selectin P Rattus norvegicus 50-60 19846210-7 2010 RESULTS: At 0.5 hour, AZD6140 strongly reduced ADP-induced P-selectin surface expression, inhibited ADP-induced platelet aggregation, and significantly reduced platelet adhesion to fibrinogen under arterial flow conditions. Adenosine Diphosphate 47-50 selectin P Rattus norvegicus 59-69 20079708-2 2010 PARG hydrolyzes glycosidic linkages of poly(ADP-ribose) synthesized by PARP and liberates ADP-ribose residues. Adenosine Diphosphate 44-47 poly(ADP-ribose) glycohydrolase Homo sapiens 0-4 20121944-7 2010 Reconstituted DmTpc1p transports thiamine pyrophosphate and, to a lesser extent, pyrophosphate, ADP, ATP and other nucleotides. Adenosine Diphosphate 96-99 Thiamine pyrophosphate carrier protein 1 Drosophila melanogaster 14-21 20121944-9 2010 The main role of DmTpc1p is to import thiamine pyrophosphate into mitochondria by exchange with intramitochondrial ATP and/or ADP. Adenosine Diphosphate 126-129 Thiamine pyrophosphate carrier protein 1 Drosophila melanogaster 17-24 20147598-0 2010 Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. Adenosine Diphosphate 102-105 heat shock protein family A (Hsp70) member 1A Homo sapiens 71-76 20079708-2 2010 PARG hydrolyzes glycosidic linkages of poly(ADP-ribose) synthesized by PARP and liberates ADP-ribose residues. Adenosine Diphosphate 44-47 poly(ADP-ribose) polymerase 1 Homo sapiens 71-75 20092359-1 2010 Poly-ADP-ribose polymerases (PARPs) catalyze transfer of ADP-ribose from NAD(+) to specific residues in their substrate proteins or to growing ADP-ribose chains. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 29-34 19875381-0 2010 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Adenosine Diphosphate 89-92 cysteine and histidine rich domain containing 1 Homo sapiens 70-77 19965780-8 2010 CONCLUSIONS: PGC-1alpha regulates reactive oxygen species generation and apoptosis in endothelial cells by increasing fatty acid oxidation and enhancing ATP/ADP translocase activity. Adenosine Diphosphate 157-160 PPARG coactivator 1 alpha Homo sapiens 13-23 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 194-197 myosin IC Homo sapiens 97-102 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 194-197 myosin IC Homo sapiens 153-158 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 194-197 myosin IC Homo sapiens 153-158 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 336-339 myosin IC Homo sapiens 97-102 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 336-339 myosin IC Homo sapiens 153-158 20039646-6 2010 Substitution of loop 1 with that of the corresponding region from tonic smooth muscle myosin II (Myo1c(1IQ)-tonic) or replacement with a single glycine (Myo1c(1IQ)-G) accelerated the release of ADP from A.M 2-3-fold in Ca(2+), whereas substitution with loop 1 from phasic muscle myosin II (Myo1c(1IQ)-phasic) accelerated the release of ADP 35-fold. Adenosine Diphosphate 336-339 myosin IC Homo sapiens 153-158 19903699-8 2010 RESULTS: Oxidatively modified fibrinogen showed less binding activity than native fibrinogen to GpIIb/IIIa coated micro beads and human platelets whereas slightly higher binding capacity to ADP induced stimulated platelets. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 30-40 19618221-4 2010 Furthermore, a twofold increase in the expression of ANT led to the reduced efficiency of oxidative phosphorylation in CMT2A cells, suggesting that MFN2 plays a role in controlling ATP/ADP exchanges. Adenosine Diphosphate 185-188 mitofusin 2 Canis lupus familiaris 148-152 19875381-5 2010 We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1. Adenosine Diphosphate 33-36 cysteine and histidine rich domain containing 1 Homo sapiens 137-144 21247400-9 2010 Because ATP/ADP generated by ectopic ATP synthase can induce NO production, substances such as CF6 can inhibit NO generation by inhibiting surface ATP/ADP production. Adenosine Diphosphate 12-15 ATP synthase peripheral stalk subunit F6 Homo sapiens 95-98 20024494-11 2010 We conclude that reduced levels of large VWF multimers associated with aortic stenosis lead to impairment of both adhesion and, especially, ADP-inducible platelet aggregation. Adenosine Diphosphate 140-143 von Willebrand factor Homo sapiens 41-44 19664589-8 2010 A combination of cyclosporin A and ADP, inhibitors of the mitochondrial permeability transition, attenuated Cyt c release, mitochondrial remodeling, and depolarization induced by BAX(oligo), but failed to influence the effects produced by t(c)BID plus BAX(mono). Adenosine Diphosphate 35-38 cytochrome c, somatic Homo sapiens 108-113 19664589-8 2010 A combination of cyclosporin A and ADP, inhibitors of the mitochondrial permeability transition, attenuated Cyt c release, mitochondrial remodeling, and depolarization induced by BAX(oligo), but failed to influence the effects produced by t(c)BID plus BAX(mono). Adenosine Diphosphate 35-38 BCL2 associated X, apoptosis regulator Homo sapiens 179-182 19664589-8 2010 A combination of cyclosporin A and ADP, inhibitors of the mitochondrial permeability transition, attenuated Cyt c release, mitochondrial remodeling, and depolarization induced by BAX(oligo), but failed to influence the effects produced by t(c)BID plus BAX(mono). Adenosine Diphosphate 35-38 BH3 interacting domain death agonist Homo sapiens 243-246 19664589-8 2010 A combination of cyclosporin A and ADP, inhibitors of the mitochondrial permeability transition, attenuated Cyt c release, mitochondrial remodeling, and depolarization induced by BAX(oligo), but failed to influence the effects produced by t(c)BID plus BAX(mono). Adenosine Diphosphate 35-38 BCL2 associated X, apoptosis regulator Homo sapiens 252-255 21247400-9 2010 Because ATP/ADP generated by ectopic ATP synthase can induce NO production, substances such as CF6 can inhibit NO generation by inhibiting surface ATP/ADP production. Adenosine Diphosphate 151-154 ATP synthase peripheral stalk subunit F6 Homo sapiens 95-98 19700402-10 2009 These results demonstrate that GPVI-induced Akt activation in platelets is dependent in part on G(i) stimulation through P2Y(12) receptor activation by secreted ADP. Adenosine Diphosphate 161-164 thymoma viral proto-oncogene 1 Mus musculus 44-47 20063989-7 2010 We report that maximally stimulating concentrations of ADP significantly increased VEGF release from platelets in both PRP and WB by 36+/-12% 36+/-12% 54+/-18% 36 +/- 12% (p < 0.05) respectively as compared to control. Adenosine Diphosphate 55-58 vascular endothelial growth factor A Homo sapiens 83-87 20063989-10 2010 As compared to thrombin receptor activation, ADP activation was a weaker stimulus for VEGF release. Adenosine Diphosphate 45-48 vascular endothelial growth factor A Homo sapiens 86-90 20063989-11 2010 We found that activation of platelets by ADP results in an increase in soluble VEGF concentrations with minimal effects on endostatin concentrations, suggesting ADP release in the tumor microenvironment may be, on balance, proangiogenic. Adenosine Diphosphate 41-44 vascular endothelial growth factor A Homo sapiens 79-83 20015340-3 2010 Here we report the crystal structures of Get3 in ADP-bound and nucleotide-free forms at 3.0 A and 2.8 A resolutions, respectively. Adenosine Diphosphate 49-52 guided entry of tail-anchored proteins factor 3, ATPase Homo sapiens 41-45 19818001-6 2010 RESULTS: ADP-inducible platelet reactivity increased linearly with age after adjustment for cardiovascular risk factors, type of intervention, medication, C-reactive protein (CRP) and renal function [using LTA 0.36% of maximal aggregation per year, 95% CI 0.08-0.64%, P = 0.013; using the VerifyNow P2Y12 assay 3.2 P2Y12 reaction units (PRU) per year, 95% CI 1.98-4.41 PRU, P < 0.001]. Adenosine Diphosphate 9-12 C-reactive protein Homo sapiens 155-173 19818001-6 2010 RESULTS: ADP-inducible platelet reactivity increased linearly with age after adjustment for cardiovascular risk factors, type of intervention, medication, C-reactive protein (CRP) and renal function [using LTA 0.36% of maximal aggregation per year, 95% CI 0.08-0.64%, P = 0.013; using the VerifyNow P2Y12 assay 3.2 P2Y12 reaction units (PRU) per year, 95% CI 1.98-4.41 PRU, P < 0.001]. Adenosine Diphosphate 9-12 C-reactive protein Homo sapiens 175-178 19487018-5 2010 Platelet activation by adenosine diphosphate (ADP) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold. Adenosine Diphosphate 23-44 CD40 ligand Homo sapiens 106-111 19487018-5 2010 Platelet activation by adenosine diphosphate (ADP) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold. Adenosine Diphosphate 46-49 CD40 ligand Homo sapiens 106-111 19996015-10 2009 CONCLUSIONS: In this prospective study of 700 aspirin-treated patients presenting for angiographic evaluation of coronary artery disease, residual platelet COX-1 function measured by serum thromboxane B(2) and COX-1-independent platelet function measured by PFA-100 collagen-ADP CT, but not indirect COX-1-dependent assays (arachidonic acid-stimulated platelet markers, shortened PFA-100 collagen-epinephrine CT), correlate with subsequent major adverse cardiovascular events. Adenosine Diphosphate 275-278 prostaglandin-endoperoxide synthase 1 Homo sapiens 156-161 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 thymoma viral proto-oncogene 1 Mus musculus 26-29 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 thymoma viral proto-oncogene 1 Mus musculus 208-211 19782047-3 2009 Binding of caldesmon altered the mobility and inhibited the rotation of actin subdomain-1 during the transition from AM * *.ADP.Pi to AM state, resulting in inhibition of both strong and weak-binding intermediate states. Adenosine Diphosphate 124-127 caldesmon 1 Homo sapiens 11-20 19700402-11 2009 In addition, a significant portion of GPVI-dependent, ADP-independent Akt activation also exists, and PI3Kbeta plays an essential role in GPVI-mediated platelet aggregation and Akt activation. Adenosine Diphosphate 54-57 thymoma viral proto-oncogene 1 Mus musculus 70-73 19700402-11 2009 In addition, a significant portion of GPVI-dependent, ADP-independent Akt activation also exists, and PI3Kbeta plays an essential role in GPVI-mediated platelet aggregation and Akt activation. Adenosine Diphosphate 54-57 thymoma viral proto-oncogene 1 Mus musculus 177-180 19935871-7 2009 Only at very high concentrations could A204C actin polymerize when ATP was bound; when hydrolyzed, the ADP-containing A204C filaments depolymerized, demonstrating a profound difference in critical concentration between ATP and ADP states with A204C actin. Adenosine Diphosphate 103-106 actin Saccharomyces cerevisiae S288C 249-254 19935871-7 2009 Only at very high concentrations could A204C actin polymerize when ATP was bound; when hydrolyzed, the ADP-containing A204C filaments depolymerized, demonstrating a profound difference in critical concentration between ATP and ADP states with A204C actin. Adenosine Diphosphate 227-230 actin Saccharomyces cerevisiae S288C 249-254 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 30-51 mitogen-activated protein kinase 1 Homo sapiens 161-165 19539600-3 2009 Activation of UCP2 has been suggested to uncouple electron transport from ATP synthesis in pancreatic beta cell mitochondria thereby decreasing glucose tolerance due to decreased insulin secretion through lower ATP/ADP ratios. Adenosine Diphosphate 215-218 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 14-18 19585541-1 2009 Poly(ADP-ribose) polymerase-1 (PARP-1) is a mammalian enzyme that attaches long branching chains of ADP-ribose to specific nuclear proteins, including itself. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-37 19002385-11 2009 Increased homocysteine and decreased adiponectin serum levels in patients with essential hypertension correlate well with changes in ADP-induced conventional platelet aggregation. Adenosine Diphosphate 133-136 adiponectin, C1Q and collagen domain containing Homo sapiens 37-48 19852688-13 2009 C-reactive protein (CRP) level in PsA patients correlated with sCD40L (r = 0.69, p = 0.012), basal CD62P expression (r = 0.89, p < 0.001) and ADP-stimulated CD62P expression (r = 0.73, p = 0.001). Adenosine Diphosphate 145-148 C-reactive protein Homo sapiens 0-18 19852688-13 2009 C-reactive protein (CRP) level in PsA patients correlated with sCD40L (r = 0.69, p = 0.012), basal CD62P expression (r = 0.89, p < 0.001) and ADP-stimulated CD62P expression (r = 0.73, p = 0.001). Adenosine Diphosphate 145-148 C-reactive protein Homo sapiens 20-23 19695217-0 2009 STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets. Adenosine Diphosphate 56-59 stromal interaction molecule 1 Homo sapiens 0-5 19764761-0 2009 Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications. Adenosine Diphosphate 22-25 poly(ADP-ribose) polymerase 1 Homo sapiens 52-58 19703650-5 2009 We hypothesize that the increased GTP formation within the Krebs cycle followed by the GTP export via the ADP/ATP carrier shift the balance between fission and fusion towards fusion by activating the GTPase domain of OPA1 located in the peripheral intermembrane space (PIMS). Adenosine Diphosphate 106-109 OPA1 mitochondrial dynamin like GTPase Homo sapiens 217-221 19515725-3 2009 We demonstrate that both isoforms were similarly required for maximal activation of the small GTPase Rap1b and for complete platelet aggregation upon stimulation of G protein-coupled receptors for adenosine 5"-diphosphate (ADP) or U46619. Adenosine Diphosphate 197-221 RAS related protein 1b Mus musculus 101-106 19897717-6 2009 In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14. Adenosine Diphosphate 54-57 ADP-ribosyltransferase 1 Homo sapiens 39-43 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 53-56 mitogen-activated protein kinase 1 Homo sapiens 161-165 19631608-6 2009 The ADP-induced soluble CD40 ligand (sCD40L) release was inhibited by either PD98059, a MEK inhibitor, or SB203580, a p38 MAPK inhibitor. Adenosine Diphosphate 4-7 mitogen-activated protein kinase kinase 7 Homo sapiens 88-91 19631608-8 2009 AT-III markedly attenuated the ADP-induced phosphorylation levels of p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 31-34 mitogen-activated protein kinase 1 Homo sapiens 73-81 19631608-10 2009 These results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 85-88 mitogen-activated protein kinase 1 Homo sapiens 172-180 18775097-4 2009 HT-AC and HT inhibited platelet aggregation induced by ADP, collagen or arachidonic acid in both whole blood and platelet-rich plasma (PRP). Adenosine Diphosphate 55-58 complement component 4 binding protein alpha Homo sapiens 135-138 19695217-4 2009 Electrotransjection of cells with anti-STIM1 (25-139) antibody, directed towards the Ca(2+)-binding motif, significantly reduced thrombin-induced aggregation and prevented ADP-evoked response. Adenosine Diphosphate 172-175 stromal interaction molecule 1 Homo sapiens 39-44 19695217-5 2009 Extracellular application of the anti-STIM1 antibody, in order to block the function of plasma membrane-located STIM1, reduced thrombin- and ADP-stimulated platelet aggregation to a lesser extent. Adenosine Diphosphate 141-144 stromal interaction molecule 1 Homo sapiens 38-43 19695217-5 2009 Extracellular application of the anti-STIM1 antibody, in order to block the function of plasma membrane-located STIM1, reduced thrombin- and ADP-stimulated platelet aggregation to a lesser extent. Adenosine Diphosphate 141-144 stromal interaction molecule 1 Homo sapiens 112-117 19695217-7 2009 These findings suggest a role of STIM1, Orai1 and hTRPC1 in thrombin- and ADP-induced platelet aggregation probably through the regulation of Ca(2+) entry, which might become targets for the development of therapeutic strategies to treat platelet hyperactivity and thrombosis disorders. Adenosine Diphosphate 74-77 stromal interaction molecule 1 Homo sapiens 33-38 19531481-0 2009 PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Adenosine Diphosphate 11-14 poly(ADP-ribose) polymerase 1 Homo sapiens 0-5 19531481-0 2009 PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Adenosine Diphosphate 11-14 fibroblast growth factor 4 Homo sapiens 68-72 19559024-4 2009 alphaB-crystallin attenuated the adenosine diphosphate (ADP)-induced phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK. Adenosine Diphosphate 33-54 mitogen-activated protein kinase 1 Homo sapiens 130-134 19559024-4 2009 alphaB-crystallin attenuated the adenosine diphosphate (ADP)-induced phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK. Adenosine Diphosphate 56-59 mitogen-activated protein kinase 1 Homo sapiens 130-134 19759867-8 2009 Interaction between ANT and Abeta may affect normal physiological function of ANT i.e. transport of ATP and ADP. Adenosine Diphosphate 108-111 amyloid beta precursor protein Homo sapiens 28-33 19637098-4 2009 SNPs in P2RY1 and ITGB3 have also been reported by some groups to affect platelet reactivity to adenosine diphosphate (ADP). Adenosine Diphosphate 96-117 integrin subunit beta 3 Homo sapiens 18-23 19637098-4 2009 SNPs in P2RY1 and ITGB3 have also been reported by some groups to affect platelet reactivity to adenosine diphosphate (ADP). Adenosine Diphosphate 119-122 integrin subunit beta 3 Homo sapiens 18-23 19429682-6 2009 SLC25A42 catalyzed only a counter-exchange transport, exhibited a high transport affinity for CoA, dephospho-CoA, ADP, and adenosine 3",5"-diphosphate, was saturable and inhibited by bongkrekic acid and other inhibitors of mitochondrial carriers to various degrees. Adenosine Diphosphate 114-117 solute carrier family 25 member 42 Homo sapiens 0-8 19372457-6 2009 Cell surface F(1)-ATPase activity (ATP hydrolysis into ADP) was stimulated by apoA-I and was inhibited by its specific inhibitor IF(1)-H49K. Adenosine Diphosphate 55-58 apolipoprotein A1 Homo sapiens 78-84 19362586-1 2009 Poly(ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze the transfer of ADP-ribose units from NAD(+) to a number of acceptor proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 30-35 19318922-2 2009 In the present study, we investigated the relationship between platelet aggregatory responses to ADP and the release of CD40L (sCD40L): an immunomodulatory compound involved in atherothrombosis - in patients undergoing PCI. Adenosine Diphosphate 97-100 CD40 ligand Homo sapiens 120-125 19318922-8 2009 Circulating CD40L is more markedly increased after PCI in patients with high ADP-induced platelet aggregation. Adenosine Diphosphate 77-80 CD40 ligand Homo sapiens 12-17 19255877-4 2009 R125 lies on a prominent cysteine-rich finger at the interface of adjacent receptor subunits, and ADP-ribosylation at this site likely places the common adenine nucleotide moiety into the ligand-binding pocket of P2X7. Adenosine Diphosphate 98-101 purinergic receptor P2X 7 Homo sapiens 213-217 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 26-30 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 270-274 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 26-30 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 270-274 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 26-30 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 73-77 19185336-7 2009 Compared to controls, ADP induced a higher increase in MONO-PLT aggregates in CSX patients (P < 0.01), which was significantly inhibited by adenosine (P < 0.01). Adenosine Diphosphate 22-25 NK2 homeobox 5 Homo sapiens 78-81 19237732-3 2009 Platelets from the index case and relatives carrying the K174E defect changed shape in response to ADP, but showed reduced and reversible aggregation in response to 10 muM ADP, unlike the maximal, sustained aggregation observed in controls. Adenosine Diphosphate 172-175 latexin Homo sapiens 168-171 19023091-4 2009 Signaling downstream of PAR-1 or PAR-4 activates phospholipase C and protein kinase C and causes autoamplification by production of thromboxane A(2), release of ADP, and generation of more thrombin. Adenosine Diphosphate 161-164 coagulation factor II thrombin receptor Homo sapiens 24-29 20144417-9 2009 The ADP-RM system is able to filter anomalous continuous glucose records and to detect abnormal administration of insulin doses with the pump. Adenosine Diphosphate 4-7 insulin Homo sapiens 114-121 19680243-3 2009 Chemical PARP1 inhibitors, PARP1 knockdown and mutation of ADP-ribose-binding residues in macroH2A1.1 abrogate macrodomain recruitment. Adenosine Diphosphate 59-62 macroH2A.1 histone Homo sapiens 90-101 19429868-8 2009 The minor allele of a 3" untranslated region (UTR) SNP (rs2769668) in VAV3 was associated with higher protein expression (P = .03) and increased P-selectin exposure after ADP activation (P = .004). Adenosine Diphosphate 171-174 vav guanine nucleotide exchange factor 3 Homo sapiens 70-74 19429868-9 2009 Furthermore the minor allele of the intronic SNP rs17786144 in ITPR1 modified Ca(2+) levels after activation with ADP (P < .004). Adenosine Diphosphate 114-117 inositol 1,4,5-trisphosphate receptor type 1 Homo sapiens 63-68 19784880-11 2009 CONCLUSIONS: The C3435T polymorphism of the MDR-1 gene influences ADP dependent platelet reactivity in patients with acute coronary syndrome but does not affect mid-term prognosis in this population. Adenosine Diphosphate 66-69 ATP binding cassette subfamily B member 1 Homo sapiens 44-49 19395672-7 2009 Evaluation of aggregation of VAMP-8(-/-) and ruby-eye platelets indicates that defective ADP release is the primary abnormality leading to impaired aggregation. Adenosine Diphosphate 89-92 vesicle-associated membrane protein 8 Mus musculus 29-35 19477186-4 2009 An enzymatic assay revealed that hSPS1 possesses low ADP hydrolysis activity in the presence of phosphate. Adenosine Diphosphate 53-56 selenophosphate synthetase 1 Homo sapiens 33-38 19477186-8 2009 The detailed mechanism of the ADP hydrolysis step and the exact function of the monovalent cation for hSPS1 catalytic reaction are proposed. Adenosine Diphosphate 30-33 selenophosphate synthetase 1 Homo sapiens 102-107 19542469-1 2009 Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain. Adenosine Diphosphate 175-178 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 75-101 19542469-1 2009 Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain. Adenosine Diphosphate 175-178 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 103-110 19542469-1 2009 Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent pathway involving ADP-ribosylation of arginine residues on the P2X(7)R ectodomain. Adenosine Diphosphate 175-178 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 220-227 19542469-5 2009 Coexpression of the cloned murine P2X(7)R with ART2.1 or ART2.2 in HEK293 cells verified that P2X(7)R is an equivalent substrate for ADP-ribosylation by either ART2.1 or ART2.2. Adenosine Diphosphate 133-136 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 34-41 19542469-5 2009 Coexpression of the cloned murine P2X(7)R with ART2.1 or ART2.2 in HEK293 cells verified that P2X(7)R is an equivalent substrate for ADP-ribosylation by either ART2.1 or ART2.2. Adenosine Diphosphate 133-136 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 94-101 19433572-8 2009 Collectively, these data suggest that mGluR5 activation upregulates I(NaP) in MSNs of the NAc, thereby inducing an ADP that results in enhanced MSN excitability. Adenosine Diphosphate 115-118 moesin Homo sapiens 78-81 19382805-8 2009 A22-bound MreB is capable of polymerization, but with assembly properties that more closely resemble those of the ADP-bound state. Adenosine Diphosphate 114-117 immunoglobulin kappa variable 3-25 (pseudogene) Homo sapiens 0-3 19346440-7 2009 Recombinant AtADF4 bound to monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibited the rate of nucleotide exchange on G-actin, indicating that AtADF4 is a bona fide actin-depolymerizing factor. Adenosine Diphosphate 87-90 actin depolymerizing factor 4 Arabidopsis thaliana 12-18 18775097-5 2009 ASA and HT-AC had a greater effect in whole blood than in PRP when ADP or collagen was used as inducer. Adenosine Diphosphate 67-70 complement component 4 binding protein alpha Homo sapiens 58-61 19306267-0 2009 Hexokinase inhibitor screening based on adenosine 5"-diphosphate determination by electrophoretically mediated microanalysis. Adenosine Diphosphate 40-64 hexokinase 1 Homo sapiens 0-10 19306267-2 2009 In this method, hexokinase activity was assayed via electrophoretically mediated microanalysis (EMMA), which combines on-column hexokinase-mediated reaction and measurement of produced adenosine 5"-diphosphate (ADP) via electrophoretical separation and UV detection. Adenosine Diphosphate 185-209 hexokinase 1 Homo sapiens 16-26 19306267-2 2009 In this method, hexokinase activity was assayed via electrophoretically mediated microanalysis (EMMA), which combines on-column hexokinase-mediated reaction and measurement of produced adenosine 5"-diphosphate (ADP) via electrophoretical separation and UV detection. Adenosine Diphosphate 211-214 hexokinase 1 Homo sapiens 16-26 19171653-8 2009 In line with this, a long-lasting depression of the ADP was elicited by the same CS that altered firing patterns of CA3 cells. Adenosine Diphosphate 52-55 carbonic anhydrase 3 Homo sapiens 116-119 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH2 Saccharomyces cerevisiae S288C 270-274 19073150-9 2009 Furthermore, ADP activated RhoA downstream of G(q) and upstream of PLC. Adenosine Diphosphate 13-16 ras homolog family member A Homo sapiens 27-31 19234185-3 2009 Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). Adenosine Diphosphate 99-102 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 68-74 19234185-3 2009 Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). Adenosine Diphosphate 99-102 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 68-74 19143920-0 2009 Development of fibrinogen gamma-chain peptide-coated, adenosine diphosphate-encapsulated liposomes as a synthetic platelet substitute. Adenosine Diphosphate 54-75 fibrinogen gamma chain Oryctolagus cuniculus 15-37 19236702-5 2009 After clopidogrel, there was a significant increase in platelet aggregation for 5 and 20 muM ADP at 33 C compared to 37 C (46 +- 5 vs. 34 +- 5% and 58 +- 4 vs. 47 +- 4%, p < 0.001, n = 8). Adenosine Diphosphate 93-96 latexin Homo sapiens 89-92 19049970-3 2009 This feature, associated with elevated cellular respiration and cytosolic ATP/ADP and NAD(+)/NADH ratios, was linked to a high expression and activity of mitochondrial glycerol-3-phosphate dehydrogenase. Adenosine Diphosphate 78-81 glycerol-3-phosphate dehydrogenase 1 Rattus norvegicus 168-202 19154428-13 2009 Stimulation of inhibitory P2Y(1) receptors by ADP generated alternatively via ecto-ATPase might be relevant in restraining ACh exocytosis when ATP saturates ecto-ATPDase activity. Adenosine Diphosphate 46-49 purinergic receptor P2Y1 Rattus norvegicus 26-32 19154428-13 2009 Stimulation of inhibitory P2Y(1) receptors by ADP generated alternatively via ecto-ATPase might be relevant in restraining ACh exocytosis when ATP saturates ecto-ATPDase activity. Adenosine Diphosphate 46-49 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 162-169 19147982-5 2009 The ablation of in vitro thrombus formation in Prkca-/- platelets was rescued by the addition of ADP, consistent with the key mechanistic finding that dense-granule biogenesis and secretion depend upon PKCalpha expression. Adenosine Diphosphate 97-100 protein kinase C, alpha Mus musculus 47-52 18987357-6 2009 Thus, human von Willebrand factor contains an RGD motif and binds equally well to adenosine diphosphate-stimulated human and rodent platelets, implying that other motifs are responsible for maintaining ligand binding affinity. Adenosine Diphosphate 82-103 von Willebrand factor Homo sapiens 12-33 19117453-2 2009 Taking advantage of the differential response of the PPECO2-Cu2+ system to ATP, ADP and AMP, we have developed fluorescence turn-off and turn-on assays that monitor the catalytic activity of adenylate kinase (ADK) in the equilibrium transphosphorylation reaction (ATP + AMP <--> 2ADP). Adenosine Diphosphate 80-83 adenosine kinase Homo sapiens 191-207 19192113-9 2009 RESULTS: Rap1b-/- platelets displayed comparable ADP-induced or thrombin-induced alpha2beta1 activation as wild-type platelets, but reduced convulxin-dependent alpha2beta1 activation. Adenosine Diphosphate 49-52 RAS related protein 1b Mus musculus 9-14 19336004-4 2009 In this study, analytical ultracentrifugation and dynamic light scattering were used to evaluate the effect of ADP and ATP binding on the conformation of the human stress-induced Hsp70.1 protein. Adenosine Diphosphate 111-114 heat shock protein family A (Hsp70) member 1A Homo sapiens 179-186 19171653-11 2009 These findings indicate that a persistent enhancement of Kv7 channels, following a transient increase in cytoplasmic Ca(2+), results in a prolonged depression of the ADP in CA3 pyramidal neurones. Adenosine Diphosphate 166-169 carbonic anhydrase 3 Homo sapiens 173-176 19237746-5 2009 The structure of DAPK-ADP-Mg(2+) was compared with a newly determined DAPK-AMP-PNP-Mg(2+) structure and the previously determined apo DAPK structure (PDB code 1jks). Adenosine Diphosphate 22-25 death associated protein kinase 1 Homo sapiens 17-21 18796456-5 2009 Interestingly, we recently observed that the relatively weak agonist ADP potentiates the production of coated-platelets by the very strong agonists collagen plus thrombin, a previously unknown role for ADP. Adenosine Diphosphate 69-72 coagulation factor II, thrombin Homo sapiens 162-170 19174471-0 2009 Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. Adenosine Diphosphate 73-76 purinergic receptor P2X 7 Homo sapiens 16-29 18706682-4 2009 RESULTS: We demonstrated that activation of platelets from both LRP8(+/-) and LRP8(-/-) mice was reduced in vitro in response to either ADP or thrombin. Adenosine Diphosphate 136-139 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Mus musculus 64-68 18706682-4 2009 RESULTS: We demonstrated that activation of platelets from both LRP8(+/-) and LRP8(-/-) mice was reduced in vitro in response to either ADP or thrombin. Adenosine Diphosphate 136-139 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor Mus musculus 78-82 18486134-7 2009 RESULTS: We documented a significant association between IP-10, IFN-gamma, IL-4 and RPR by both AA- and ADP-induced platelet aggregation after adjustment for age, sex, cardiovascular risk factors, ejection fraction, BMI, vWF and CRP. Adenosine Diphosphate 104-107 interleukin 4 Homo sapiens 75-79 18948190-2 2009 We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13)-mediated high-density lipoprotein (HDL) endocytosis pathway. Adenosine Diphosphate 154-157 apolipoprotein A1 Homo sapiens 58-76 19273119-6 2009 Recent evidence shows that poly-ADP ribose (PAR) polymer itself can act as a cell death effector downstream of PARP-1. Adenosine Diphosphate 31-35 poly(ADP-ribose) polymerase 1 Homo sapiens 111-117 19049516-3 2009 The reaction requires physical contact between myokinase and adenosine kinase, and the net reaction is aided by the presence of adenosine deaminase (EC 3.5.4.4), which fills the gap in the energy balance of the phosphoryl transfer and shifts the equilibrium towards ADP and inosine synthesis. Adenosine Diphosphate 266-269 adenylate kinase 1 Rattus norvegicus 47-56 19049516-4 2009 The proposed mechanism involves the association of adenosine kinase and myokinase through non-covalent, transient interactions that induce slight conformational changes in the active site of myokinase, bringing two already bound molecules of AMP together for phosphoryl transfer to form ADP. Adenosine Diphosphate 287-290 adenylate kinase 1 Rattus norvegicus 72-81 19049516-4 2009 The proposed mechanism involves the association of adenosine kinase and myokinase through non-covalent, transient interactions that induce slight conformational changes in the active site of myokinase, bringing two already bound molecules of AMP together for phosphoryl transfer to form ADP. Adenosine Diphosphate 287-290 adenylate kinase 1 Rattus norvegicus 191-200 19262751-9 2009 The finding that in normal cells Parp1 and ADP-ribose polymers localize on the Dnmt1 promoter raises the possibility that PARylated Parp1 marks those sequences in the genome that must remain unmethylated and protects them from methylation, thus playing a role in the epigenetic regulation of gene expression. Adenosine Diphosphate 43-46 DNA methyltransferase (cytosine-5) 1 Mus musculus 79-84 19063607-11 2008 Overall, these results suggest that the rate of release of ADP by NBD1 in the D793E background may be the rate-limiting step in the transport cycle of MRP1. Adenosine Diphosphate 59-62 ATP binding cassette subfamily C member 1 Homo sapiens 151-155 19158948-5 2009 In contrast, mPAP dephosphorylated all purine nucleotides (AMP, ADP, ATP) at an acidic pH (pH 5.6). Adenosine Diphosphate 64-67 acid phosphatase, prostate Mus musculus 13-17 18728221-2 2008 Glucose exerts its effects on insulin secretion via its metabolism in beta-cells to generate stimulus/secretion coupling factors, including a rise in the ATP/ADP ratio, which serves to suppress ATP-sensitive K(+) (K(ATP)) channels and activate voltage-gated Ca(2+) channels, leading to stimulation of insulin granule exocytosis. Adenosine Diphosphate 158-161 insulin Homo sapiens 30-37 18775989-5 2008 Nevertheless ATP, ADP, and UTP promoted a large increase in [Ca2+]i, moderate proliferation (6 times), a reduction in the primitive Gr-1(-)Mac-1(-)c-Kit+ population, and differentiation into macrophages without participation of GJ. Adenosine Diphosphate 18-21 integrin alpha M Mus musculus 132-144 18805924-3 2008 CFTR exhibits two types of enzymatic activity: 1), ATPase activity in the presence of ATP and 2), adenylate kinase activity in the presence of ATP plus physiologic concentrations of AMP or ADP. Adenosine Diphosphate 189-192 CF transmembrane conductance regulator Homo sapiens 0-4 18515165-4 2008 For rainbow trout myofibrils at a high pyruvate kinase activity, creatine kinase competed for ADP but did not influence the total ATPase activity. Adenosine Diphosphate 94-97 creatine kinase, testis isozyme Oncorhynchus mykiss 65-80 18771651-6 2008 ATP or a combination of cyclosporin A and ADP, inhibitors of the mPT, suppressed BAX(oligo)-induced mitochondrial swelling and depolarization as well as cytochrome c release but did not influence BAX(oligo) insertion into the OMM. Adenosine Diphosphate 42-45 BCL2 associated X, apoptosis regulator Homo sapiens 81-84 18771651-6 2008 ATP or a combination of cyclosporin A and ADP, inhibitors of the mPT, suppressed BAX(oligo)-induced mitochondrial swelling and depolarization as well as cytochrome c release but did not influence BAX(oligo) insertion into the OMM. Adenosine Diphosphate 42-45 cytochrome c, somatic Homo sapiens 153-165 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Diphosphate 21-24 tumor necrosis factor Homo sapiens 102-110 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Diphosphate 21-24 ubiquitin associated and SH3 domain containing B Homo sapiens 118-121 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Diphosphate 21-24 interferon gamma Homo sapiens 127-135 18567585-8 2008 Considering the concentrations of ADP and ATP in E. coli, ADP is expected to have a small effect on the inhibition of GroES binding to the trans-ring of GroEL in vivo. Adenosine Diphosphate 34-37 GroEL Escherichia coli 153-158 18567585-8 2008 Considering the concentrations of ADP and ATP in E. coli, ADP is expected to have a small effect on the inhibition of GroES binding to the trans-ring of GroEL in vivo. Adenosine Diphosphate 58-61 GroEL Escherichia coli 153-158 18619441-3 2008 Cellular PARP-1 activity was recovered when the centrifugal sediment was recombined with the supernatant fraction containing cellular ADP-ribose oligomer acceptor proteins. Adenosine Diphosphate 134-137 poly(ADP-ribose) polymerase 1 Homo sapiens 9-15 18515165-2 2008 The ATPase rate was assessed by recording the rephosphorylation of ADP by the pyruvate kinase reaction alone or together with the amount of creatine formed, when myofibrillar bound creatine kinase was activated with phosphocreatine. Adenosine Diphosphate 67-70 pyruvate kinase PKM Oncorhynchus mykiss 78-93 18515165-2 2008 The ATPase rate was assessed by recording the rephosphorylation of ADP by the pyruvate kinase reaction alone or together with the amount of creatine formed, when myofibrillar bound creatine kinase was activated with phosphocreatine. Adenosine Diphosphate 67-70 creatine kinase, testis isozyme Oncorhynchus mykiss 181-196 18515165-3 2008 The steady-state concentration of ADP in the solution was varied through the activity of pyruvate kinase added to the solution. Adenosine Diphosphate 34-37 pyruvate kinase PKM Oncorhynchus mykiss 89-104 18486134-7 2009 RESULTS: We documented a significant association between IP-10, IFN-gamma, IL-4 and RPR by both AA- and ADP-induced platelet aggregation after adjustment for age, sex, cardiovascular risk factors, ejection fraction, BMI, vWF and CRP. Adenosine Diphosphate 104-107 interferon gamma Homo sapiens 64-73 18646252-5 2008 The YMESRADR octapeptide inhibits ADP-stimulated human platelets aggregation and binds to immobilized fibrinogen. Adenosine Diphosphate 34-37 fibrinogen beta chain Homo sapiens 102-112 18755689-2 2008 We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. Adenosine Diphosphate 14-17 proline rich transmembrane protein 2 Homo sapiens 89-92 18854029-1 2008 BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins. Adenosine Diphosphate 170-173 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) Homo sapiens 18-22 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. Adenosine Diphosphate 0-3 ubiquitin associated and SH3 domain containing B Homo sapiens 63-66 18521569-9 2008 ADP, ATPgammaS, BzATP, and CV1808, but not UTP displayed IL-12(p70) and IFNgamma reducing effect similar to ATP. Adenosine Diphosphate 0-3 interferon gamma Homo sapiens 72-80 18665919-4 2008 RESULTS: Treatment of platelets with thrombin or ADP induces activation and mitochondrial association of active Bid, Bax and Bak. Adenosine Diphosphate 49-52 BH3 interacting domain death agonist Homo sapiens 112-115 18665919-4 2008 RESULTS: Treatment of platelets with thrombin or ADP induces activation and mitochondrial association of active Bid, Bax and Bak. Adenosine Diphosphate 49-52 BCL2 associated X, apoptosis regulator Homo sapiens 117-120 18564385-2 2008 We demonstrate that AtBT1 transports AMP, ADP and ATP (but not ADP-glucose), shows a unidirectional mode of transport, and locates to the plastidial membrane and not to the ER as previously proposed. Adenosine Diphosphate 42-45 BTB and TAZ domain protein 1 Arabidopsis thaliana 20-25 18658136-5 2008 The 2.0-A crystal structures of the PDK4 dimer with bound ADP reveal an open conformation with a wider active-site cleft, compared with that in the closed conformation epitomized by the PDK2-ADP structure. Adenosine Diphosphate 58-61 pyruvate dehydrogenase kinase 4 Homo sapiens 36-40 18658136-5 2008 The 2.0-A crystal structures of the PDK4 dimer with bound ADP reveal an open conformation with a wider active-site cleft, compared with that in the closed conformation epitomized by the PDK2-ADP structure. Adenosine Diphosphate 191-194 pyruvate dehydrogenase kinase 4 Homo sapiens 36-40 18658136-10 2008 We propose that PDK4 with bound ADP exists in equilibrium between the open and the closed conformations. Adenosine Diphosphate 32-35 pyruvate dehydrogenase kinase 4 Homo sapiens 16-20 18588898-5 2008 To explain this phenomenon, we performed binding experiments with a peptide construct of the tail to establish its specificity for Aacpn10del-25 and used cryo-electron microscopy to determine the three-dimensional (3D) structure of the GroEL-Aacpn10-ADP complex at an 8-A resolution. Adenosine Diphosphate 250-253 GroEL Escherichia coli 236-241 18567585-7 2008 Furthermore, we showed that ADP prevents the association of ATP to the trans-ring of GroEL, and as a consequence, the second GroES cannot bind to GroEL. Adenosine Diphosphate 28-31 GroEL Escherichia coli 85-90 18515165-5 2008 When the ADP concentration was elevated within the physiological range by lowering the pyruvate kinase activity, creatine kinase competed efficiently and increased the ATPase activity twice or more for both trout and turtle. Adenosine Diphosphate 9-12 pyruvate kinase PKM Oncorhynchus mykiss 87-102 18515165-5 2008 When the ADP concentration was elevated within the physiological range by lowering the pyruvate kinase activity, creatine kinase competed efficiently and increased the ATPase activity twice or more for both trout and turtle. Adenosine Diphosphate 9-12 creatine kinase, testis isozyme Oncorhynchus mykiss 113-128 18550799-4 2008 In vitro experiments with OOC-5, a torsinA homolog from Caenorhabditis elegans, demonstrate that redox changes that reduce this disulfide bond affect the binding of ATP and ADP and cause an attendant local conformational change detected by limited proteolysis. Adenosine Diphosphate 173-176 Torsin-like protein Caenorhabditis elegans 26-31 18791942-5 2008 In addition, properdin significantly amplified ADP-induced aggregation of platelets with leukocytes by 53% (p < 0.05), while it had no effect on ADP-induced aggregation of platelets alone. Adenosine Diphosphate 47-50 complement factor properdin Homo sapiens 13-22 18534980-8 2008 CcO isolated after TNFalpha treatment showed tyrosine phosphorylation on CcO catalytic subunit I and was approximately 50 and 70% inhibited at high cytochrome c concentrations in the presence of allosteric activator ADP and inhibitor ATP, respectively. Adenosine Diphosphate 216-219 tumor necrosis factor Mus musculus 19-27 18385991-1 2008 OBJECTIVE: Clopidogrel is activated by cytochrome P450 3A (CYP3A) to generate an active metabolite that inhibits adenosine diphosphate (ADP)-induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. Adenosine Diphosphate 113-134 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-57 18578509-8 2008 Inhibition of release of ADP by tail domains is reversed by Unc-76 (FEZ1) which is a potential regulator of kinesin-1. Adenosine Diphosphate 25-28 fasciculation and elongation protein zeta 1 Homo sapiens 60-66 18578509-8 2008 Inhibition of release of ADP by tail domains is reversed by Unc-76 (FEZ1) which is a potential regulator of kinesin-1. Adenosine Diphosphate 25-28 fasciculation and elongation protein zeta 1 Homo sapiens 68-72 18445610-8 2008 Tirofiban significantly inhibited SPA, fib (2, 4, 8 g/L), ADP, ADP + fib combination, and 5HT-induced aggregation. Adenosine Diphosphate 58-61 fibrinogen beta chain Homo sapiens 4-7 18611377-2 2008 We report the structure of a DAG kinase, DgkB from Staphylococcus aureus, both as the free enzyme and in complex with ADP. Adenosine Diphosphate 118-121 diacylglycerol kinase beta Homo sapiens 41-45 18414379-9 2008 Of several P2Y1 receptor inhibitors, only SCH202676, which has a proposed allosteric mechanism of action, could block ADP-induced voltage-dependent Ca2+ release. Adenosine Diphosphate 118-121 purinergic receptor P2Y1 Rattus norvegicus 11-15 18385991-1 2008 OBJECTIVE: Clopidogrel is activated by cytochrome P450 3A (CYP3A) to generate an active metabolite that inhibits adenosine diphosphate (ADP)-induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. Adenosine Diphosphate 113-134 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 59-64 18385991-1 2008 OBJECTIVE: Clopidogrel is activated by cytochrome P450 3A (CYP3A) to generate an active metabolite that inhibits adenosine diphosphate (ADP)-induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. Adenosine Diphosphate 136-139 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-57 18385991-1 2008 OBJECTIVE: Clopidogrel is activated by cytochrome P450 3A (CYP3A) to generate an active metabolite that inhibits adenosine diphosphate (ADP)-induced platelet aggregation through irreversible binding to the platelet P2Y12 receptor. Adenosine Diphosphate 136-139 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 59-64 18432522-6 2008 Thrombin-induced PLD activity was enhanced by secreted ADP and binding of fibrinogen to its receptors. Adenosine Diphosphate 55-58 coagulation factor II, thrombin Homo sapiens 0-8 18183622-6 2008 ADP stimulation induced Akt phosphorylation in microglia, and the phosphorylation was inhibited by a P2Y12 receptor antagonist, AR-C69931MX. Adenosine Diphosphate 0-3 AKT serine/threonine kinase 1 Homo sapiens 24-27 18183622-8 2008 These results indicate that Akt activation is dependent on the PI3K pathway and a PLC-mediated increase in intracellular calcium and suggest that Akt activation is involved in ADP-induced microglial chemotaxis. Adenosine Diphosphate 176-179 AKT serine/threonine kinase 1 Homo sapiens 28-31 18183622-8 2008 These results indicate that Akt activation is dependent on the PI3K pathway and a PLC-mediated increase in intracellular calcium and suggest that Akt activation is involved in ADP-induced microglial chemotaxis. Adenosine Diphosphate 176-179 AKT serine/threonine kinase 1 Homo sapiens 146-149 17992570-4 2008 Based on calculated V (ATP)/V (ADP) ratio it was concluded that ATP/ADP hydrolysis was primarily catalyzed by NTPDase1 enzyme form. Adenosine Diphosphate 31-34 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 110-118 17992570-4 2008 Based on calculated V (ATP)/V (ADP) ratio it was concluded that ATP/ADP hydrolysis was primarily catalyzed by NTPDase1 enzyme form. Adenosine Diphosphate 68-71 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 110-118 18432522-6 2008 Thrombin-induced PLD activity was enhanced by secreted ADP and binding of fibrinogen to its receptors. Adenosine Diphosphate 55-58 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 18417691-4 2008 Mitochondria from SOD1(G93A) rat astrocytes displayed a defective respiratory function, including decreased oxygen consumption, lack of ADP-dependent respiratory control, and decreased membrane potential. Adenosine Diphosphate 136-139 superoxide dismutase 1 Rattus norvegicus 18-22 18343032-3 2008 ADP also evoked a robust increase in extracellular signal-regulated protein kinase (ERK) phosphorylation that was of similar magnitude in the cultures from wild type and P2Y(1) receptor deficient mice. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 1 Mus musculus 37-82 18343032-3 2008 ADP also evoked a robust increase in extracellular signal-regulated protein kinase (ERK) phosphorylation that was of similar magnitude in the cultures from wild type and P2Y(1) receptor deficient mice. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 1 Mus musculus 84-87 18174159-5 2008 Blocking RyR channels, but not sarco/endoplasmic reticulum ATPase (SERCA) pumps, reduced the ATP/ADP ratio. Adenosine Diphosphate 97-100 ryanodine receptor 1 Homo sapiens 9-12 17959249-5 2008 In platelet-rich plasma, CD40L mAb neither induced platelet aggregation per se, nor significantly affected maximal aggregation or slope of ADP-induced aggregation curves. Adenosine Diphosphate 139-142 CD40 ligand Homo sapiens 25-30 18281290-1 2008 ATP/ADP-sensing (sulfonylurea receptor (SUR)/K(IR)6)(4) K(ATP) channels regulate the excitability of our insulin secreting and other vital cells via the differential MgATP/ADP-dependent stimulatory actions of their tissue-specific ATP-binding cassette regulatory subunits (sulfonylurea receptors), which counterbalance the nearly constant inhibitory action of ATP on the K(+) inwardly rectifying pore. Adenosine Diphosphate 4-7 insulin Homo sapiens 105-112 18216148-3 2008 Application of P2Y agonists to rat urothelial cells evoked increases in intracellular calcium; the rank order of agonist potency (pEC(50) +/- SE) was ATP (5.10 +/- 0.07) > UTP (4.91 +/- 0.14) > UTPgammaS (4.61 +/- 0.16) = ATPgammaS (4.70 +/- 0.05) > 2-methylthio adenosine 5"-diphosphate = 5"-(N-ethylcarboxamido)adenosine = ADP (<3.5). Adenosine Diphosphate 334-337 purinergic receptor P2Y1 Rattus norvegicus 15-18 18317590-2 2008 Here, using SERT-deficient mice, we have established a role for constitutive SERT expression in efficient ADP- and thrombin-triggered platelet aggregation. Adenosine Diphosphate 106-109 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 12-16 18317590-2 2008 Here, using SERT-deficient mice, we have established a role for constitutive SERT expression in efficient ADP- and thrombin-triggered platelet aggregation. Adenosine Diphosphate 106-109 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Mus musculus 77-81 18419595-8 2008 Thus, exposure of cardiomyocytes to elevated concentrations of ATP or ADP in the presence of TNF-alpha contributes to cell death, an effect which is counteracted by uracil-preferring P2 receptors. Adenosine Diphosphate 70-73 tumor necrosis factor Mus musculus 93-102 18324728-4 2008 This is achieved by coupling the formation of ATP, as a consequence of gamma-phosphate transfer from NTP to ADP, to hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PDH), oxidized nicotinamide adenine dinucleotide phosphate (NADP), phenazine methosulfate (PMS), and iodonitrotetrazolium chloride (INT). Adenosine Diphosphate 108-111 hexokinase 1 Homo sapiens 116-126 18324728-4 2008 This is achieved by coupling the formation of ATP, as a consequence of gamma-phosphate transfer from NTP to ADP, to hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PDH), oxidized nicotinamide adenine dinucleotide phosphate (NADP), phenazine methosulfate (PMS), and iodonitrotetrazolium chloride (INT). Adenosine Diphosphate 108-111 hexokinase 1 Homo sapiens 128-130 18078995-6 2008 Interestingly, PARP is activated during T cell stimulation in the absence of DNA damage, leading to ADP-ribose polymers formation and transfer to nuclear acceptor proteins. Adenosine Diphosphate 100-103 poly(ADP-ribose) polymerase 1 Homo sapiens 15-19 18278866-8 2008 TLL inhibited significantly ADP and epinephrine-induced platelet aggregation in a concentration-dependent manner (IC 50=0.40 and 0.32 mg/mL, respectively). Adenosine Diphosphate 28-31 tolloid like 1 Homo sapiens 0-3 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 3 Homo sapiens 88-94 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 8 Homo sapiens 172-175 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 1 Homo sapiens 180-183 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 PYD and CARD domain containing Homo sapiens 193-197 18174464-10 2008 We conclude that ADP promotes human endothelial cell migration by activating P2Y1 receptor-mediated MAPK pathways, possibly contributing to reendothelialization and angiogenesis after vascular injury. Adenosine Diphosphate 17-20 mitogen-activated protein kinase 3 Homo sapiens 100-104 18305394-7 2008 Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca(2+) release and/or cAMP-activated PKA were the main contributors to extracellular ATP-(or ADP)-mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 (a P2Y(1) antagonist) or 5"-AMPS (a P2Y(11) antagonist), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression. Adenosine Diphosphate 193-196 purinergic receptor P2Y1 Rattus norvegicus 286-292 18305394-7 2008 Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca(2+) release and/or cAMP-activated PKA were the main contributors to extracellular ATP-(or ADP)-mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 (a P2Y(1) antagonist) or 5"-AMPS (a P2Y(11) antagonist), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression. Adenosine Diphosphate 193-196 purinergic receptor P2Y1 Rattus norvegicus 365-371 18021304-7 2008 ADP, collagen, and ADP plus collagen accelerated the kinetics of thrombin generation in recalcified whole blood and R-138727 significantly inhibited this acceleration. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 65-73 18021304-7 2008 ADP, collagen, and ADP plus collagen accelerated the kinetics of thrombin generation in recalcified whole blood and R-138727 significantly inhibited this acceleration. Adenosine Diphosphate 19-22 coagulation factor II, thrombin Homo sapiens 65-73 18025084-1 2008 Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units to chromatin-associated proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-36 18296626-3 2008 Functional integration of ER-ANT1 in the cytoplasmic membrane of intact Escherichia coli cells reveals a high specificity for an ATP/ADP antiport. Adenosine Diphosphate 133-136 aromatic and neutral transporter 1 Arabidopsis thaliana 29-33 17914025-5 2008 Akt1 and Akt2 play important roles in early GPIb-IX signaling independent of Syk, adenosine diphosphate (ADP), or thromboxane A2 (TXA2), in addition to their recognized roles in ADP- and TXA2-dependent secondary amplification pathways. Adenosine Diphosphate 178-181 AKT serine/threonine kinase 1 Homo sapiens 0-4 18758128-3 2008 ADP markedly caused the phosphorylation of Akt in the platelets obtained at 24 weeks. Adenosine Diphosphate 0-3 AKT serine/threonine kinase 1 Homo sapiens 43-46 18005987-8 2008 Two structures of human glutamine synthetase represent complexes with: a) phosphate, ADP, and manganese, and b) a phosphorylated form of the inhibitor methionine sulfoximine, ADP and manganese; these structures were refined to resolutions of 2.05 A and 2.6 A, respectively. Adenosine Diphosphate 85-88 glutamate-ammonia ligase Homo sapiens 24-44 18005987-8 2008 Two structures of human glutamine synthetase represent complexes with: a) phosphate, ADP, and manganese, and b) a phosphorylated form of the inhibitor methionine sulfoximine, ADP and manganese; these structures were refined to resolutions of 2.05 A and 2.6 A, respectively. Adenosine Diphosphate 175-178 glutamate-ammonia ligase Homo sapiens 24-44 17630652-4 2008 The following parameters were quantified by cytometry after stimulation with adenosine diphosphate (ADP) (0.5, 1, 2, 5, 10, 20 muM): CD62P (P-selectin) and PAC-1 expression, and cytosolic Ca(2+) mobilization. Adenosine Diphosphate 77-98 latexin Homo sapiens 127-130 18081863-1 2008 During thrombus formation, thrombin, which is abundantly present at sites of vascular injury, activates platelets in part via autocrine-produced ADP. Adenosine Diphosphate 145-148 coagulation factor II, thrombin Homo sapiens 27-35 18081863-3 2008 Even at high thrombin concentration, autocrine and added ADP enhanced and prolonged Ca(2+) depletion from internal stores via stimulation of the P2Y(12) receptors. Adenosine Diphosphate 57-60 coagulation factor II, thrombin Homo sapiens 13-21 18436469-0 2008 Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation. Adenosine Diphosphate 82-85 poly(ADP-ribose) polymerase 2 Homo sapiens 39-45 18436469-5 2008 Finally, PARP-2 with mutated lysines 36 and 37 showed reduced auto-mono-ADP-ribosylation when compared to wild type PARP-2. Adenosine Diphosphate 72-75 poly(ADP-ribose) polymerase 2 Homo sapiens 9-15 18172112-9 2008 Maximal responses to ADP and 2MeSATP were equivalent with EC(50)s of 1 muM and 0.3 muM. Adenosine Diphosphate 21-24 latexin Homo sapiens 71-74 18758128-5 2008 The platelet hyper-aggregability and Akt phosphorylation induced by ADP disappeared at 4 weeks after the cessation of medication. Adenosine Diphosphate 68-71 AKT serine/threonine kinase 1 Homo sapiens 37-40 18172112-9 2008 Maximal responses to ADP and 2MeSATP were equivalent with EC(50)s of 1 muM and 0.3 muM. Adenosine Diphosphate 21-24 latexin Homo sapiens 83-86 18094219-1 2008 Prasugrel, a thienopyridine prodrug, is hydrolyzed in vivo by esterases to a thiolactone followed by a single cytochrome P450 (CYP)-dependent step to an active metabolite that is a potent inhibitor of adenosine diphosphate-induced platelet aggregation. Adenosine Diphosphate 201-222 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 110-125 18094219-1 2008 Prasugrel, a thienopyridine prodrug, is hydrolyzed in vivo by esterases to a thiolactone followed by a single cytochrome P450 (CYP)-dependent step to an active metabolite that is a potent inhibitor of adenosine diphosphate-induced platelet aggregation. Adenosine Diphosphate 201-222 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 127-130 18031938-3 2007 NTPDase2 converts ATP and UTP to ADP and UDP, respectively, which are all P2Y receptor agonists. Adenosine Diphosphate 33-36 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 0-8 19127086-10 2008 RESULTS: Both maximal aggregation and the slope of aggregation correlate with the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP. Adenosine Diphosphate 154-157 fibrinogen beta chain Homo sapiens 117-127 19127086-11 2008 The best correlation was seen between the slope of aggregation induced by 0.2 or 1 microM ADP and the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP (for 0.2 microM r = 0.62, p = 0.038; for 1 microM r = 0.71, p = 0.025). Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 137-147 19127086-11 2008 The best correlation was seen between the slope of aggregation induced by 0.2 or 1 microM ADP and the percentage of platelets that bound fibrinogen in response to 0.2 microM ADP (for 0.2 microM r = 0.62, p = 0.038; for 1 microM r = 0.71, p = 0.025). Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 137-147 17705672-5 2008 The presence of SNP ADP+276 G>T allele was accompanied by higher cholesterol levels in AN patients, higher adiponectin concentrations in OB patients and lower HbA1c levels in NW. Adenosine Diphosphate 20-23 adiponectin, C1Q and collagen domain containing Homo sapiens 110-121 18174464-5 2008 In addition, both ADP and 2-MeSADP, but not AMP, activated the mitogen-activated protein kinase pathways as evidenced by increased phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 kinase. Adenosine Diphosphate 18-21 mitogen-activated protein kinase 1 Homo sapiens 150-196 18174464-5 2008 In addition, both ADP and 2-MeSADP, but not AMP, activated the mitogen-activated protein kinase pathways as evidenced by increased phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 kinase. Adenosine Diphosphate 18-21 mitogen-activated protein kinase 8 Homo sapiens 198-221 18174464-5 2008 In addition, both ADP and 2-MeSADP, but not AMP, activated the mitogen-activated protein kinase pathways as evidenced by increased phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 kinase. Adenosine Diphosphate 18-21 mitogen-activated protein kinase 8 Homo sapiens 223-226 18174464-5 2008 In addition, both ADP and 2-MeSADP, but not AMP, activated the mitogen-activated protein kinase pathways as evidenced by increased phosphorylation of extracellular signal-regulated kinase (ERK)1/2, c-Jun N-terminal kinase (JNK), and p38 kinase. Adenosine Diphosphate 18-21 mitogen-activated protein kinase 1 Homo sapiens 233-236 17965924-3 2007 Like other ABC transporters CFTR is an ATPase (ATP + H(2)O --> ADP + Pi). Adenosine Diphosphate 66-69 CF transmembrane conductance regulator Homo sapiens 28-32 17586498-5 2007 We report here that GAPDH and cysteine synthase A are the main ADP-ribosylated proteins in Entamoeba histolytica extracellular medium, GAPDH is secreted from ameba at 37 degrees C in a time-dependent manner, and its enzymatic activity is not inhibited by ADP-ribosylation. Adenosine Diphosphate 63-66 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 20-25 17586498-5 2007 We report here that GAPDH and cysteine synthase A are the main ADP-ribosylated proteins in Entamoeba histolytica extracellular medium, GAPDH is secreted from ameba at 37 degrees C in a time-dependent manner, and its enzymatic activity is not inhibited by ADP-ribosylation. Adenosine Diphosphate 63-66 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 135-140 17965924-6 2007 Why does ADP inhibit CFTR current? Adenosine Diphosphate 9-12 CF transmembrane conductance regulator Homo sapiens 21-25 17883592-8 2007 Stimulation of PAR1 or PAR4 resulted in rapid Akt phosphorylation, independently of secreted ADP and phosphatidylinositol-3-kinase (PI3K) activation. Adenosine Diphosphate 93-96 coagulation factor II thrombin receptor Homo sapiens 15-19 17883592-11 2007 CONCLUSIONS: Platelet PAR stimulation causes rapid Akt phosphorylation downstream of PLC, whereas with continuous stimulation, ADP and PI3K are required for maintaining Akt phosphorylation. Adenosine Diphosphate 127-130 AKT serine/threonine kinase 1 Homo sapiens 169-172 17885093-8 2007 In addition, ADP-induced platelet aggregation in vitro was similarly reduced by iloprost (100 nM) in iNOS-/- mice and WT congeners. Adenosine Diphosphate 13-16 nitric oxide synthase 2, inducible Mus musculus 101-105 18023664-10 2007 RESULTS: Diabetic animals exhibited significant impairments in endothelium-dependent microvessel relaxation to adenosine diphosphate and substance P, which were reversed in insulin-treated animals. Adenosine Diphosphate 111-132 insulin Homo sapiens 173-180 17715127-4 2007 Mass spectrometry analysis of proteins that coimmunoprecipitate with SIRT4 identified insulindegrading enzyme and the ADP/ATP carrier proteins, ANT2 and ANT3. Adenosine Diphosphate 118-121 sirtuin 4 Homo sapiens 69-74 17785464-2 2007 Using two JNK inhibitors (SP600125 and 6o), we have demonstrated that JNK1 is involved in collagen-induced platelet aggregation dependent on ADP. Adenosine Diphosphate 141-144 mitogen-activated protein kinase 8 Homo sapiens 10-13 17923106-3 2007 There are evidences that some positive and negative modulators of PFK, such as ADP and citrate, may interfere with the enzyme oligomeric structure shifting the tetramer-dimer equilibrium towards opposite orientations, where the negative modulators favor the dissociation of tetramers into dimers and vice versa. Adenosine Diphosphate 79-82 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 66-69 17785464-2 2007 Using two JNK inhibitors (SP600125 and 6o), we have demonstrated that JNK1 is involved in collagen-induced platelet aggregation dependent on ADP. Adenosine Diphosphate 141-144 mitogen-activated protein kinase 8 Homo sapiens 70-74 17822411-0 2007 ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis. Adenosine Diphosphate 0-3 cytochrome c, somatic Homo sapiens 82-94 17875745-4 2007 In living cells, cofilin is not necessary for actin assembly on endocytic membranes but is recruited to molecularly aged adenosine diphosphate actin filaments and is necessary for their rapid disassembly. Adenosine Diphosphate 121-142 actin Saccharomyces cerevisiae S288C 143-148 17562166-1 2007 The Na(+) and Ca(2+)-permeable melastatin related transient receptor potential (TRPM2) cation channels can be gated either by ADP-ribose (ADPR) in concert with Ca(2+) or by hydrogen peroxide (H(2)O(2)), an experimental model for oxidative stress, and binding to the channel"s enzymatic Nudix domain. Adenosine Diphosphate 126-129 transient receptor potential cation channel subfamily M member 2 Cricetulus griseus 80-85 17294140-11 2007 Thus, ADP acting on the endothelial P2Y(1) receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 6-9 plasminogen activator, tissue type Sus scrofa 75-79 17294140-11 2007 Thus, ADP acting on the endothelial P2Y(1) receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 198-201 plasminogen activator, tissue type Sus scrofa 75-79 17294140-19 2007 Thus, ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 6-9 plasminogen activator, tissue type Sus scrofa 77-81 17294140-19 2007 Thus, ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 200-203 plasminogen activator, tissue type Sus scrofa 77-81 17673465-4 2007 We demonstrate that p110 beta is primarily responsible for G(i)-dependent phosphatidylinositol 3,4-bisphosphate (PI(3,4)P(2)) production in ADP-stimulated platelets and is linked to the activation of Rap1b and AKT. Adenosine Diphosphate 140-143 RAS related protein 1b Mus musculus 200-205 17673465-4 2007 We demonstrate that p110 beta is primarily responsible for G(i)-dependent phosphatidylinositol 3,4-bisphosphate (PI(3,4)P(2)) production in ADP-stimulated platelets and is linked to the activation of Rap1b and AKT. Adenosine Diphosphate 140-143 thymoma viral proto-oncogene 1 Mus musculus 210-213 17910474-9 2007 Although having a considerably higher specificity constant kcat/Km for ADP as for ATP, the bacterially expressed variant of NTPDase1 in contrast to its wild type counterpart releases intermediate ADP to a substantial amount. Adenosine Diphosphate 71-74 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 124-132 17910474-9 2007 Although having a considerably higher specificity constant kcat/Km for ADP as for ATP, the bacterially expressed variant of NTPDase1 in contrast to its wild type counterpart releases intermediate ADP to a substantial amount. Adenosine Diphosphate 196-199 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 124-132 17656657-6 2007 Before surgery, clopidogrel produced a significant reduction in the platelet response to ADP; for example, with 10(-6)M ADP, 77.32+/-2.3% bound fibrinogen in placebo group compared with 67.16+/-3.1% after clopidogrel (P=0.01). Adenosine Diphosphate 120-123 fibrinogen beta chain Homo sapiens 144-154 18457045-1 2007 Oxidatively-modified fibrinogen induces platelet aggregation and potentiates ADP-induced platelet aggregation and production of active oxygen forms in zymosan-stimulated leukocytes. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 21-31 18457045-4 2007 Oxidized fibrinogen modified blood clotting parameters and ADP-, ristocetin-, and collagen-induced platelet aggregation in whole blood. Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 9-19 18457045-6 2007 Platelet aggregation was activated in response to ADP, but not to ristocetin and collagen, the degree of activation increased in direct proportion to the degree of fibrinogen oxidation. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 164-174 17425670-1 2007 We show that Arf3p, a member of the ADP ribosylation family, is involved in the organization of actin cables and cortical patches in Saccharomyces cerevisiae. Adenosine Diphosphate 36-39 Arf family GTPase ARF3 Saccharomyces cerevisiae S288C 13-18 17656657-7 2007 This was accentuated after surgery when the percentage of platelets binding fibrinogen in response to ADP was 76.53+/-2.2% in patients given placebo and 62.84+/-3.3% in the clopidogrel group (P=0.002). Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 76-86 17239901-2 2007 We report here the X-ray crystal structure of Sky1p bound to a substrate peptide and ADP. Adenosine Diphosphate 85-88 serine/threonine protein kinase SKY1 Saccharomyces cerevisiae S288C 46-51 17490600-1 2007 We have developed a highly sensitive assay of MEK-mediated ATP hydrolysis by coupling the formation of ADP to NADH oxidation through the enzymes pyruvate kinase and lactate dehydrogenase. Adenosine Diphosphate 103-106 mitogen-activated protein kinase kinase 7 Homo sapiens 46-49 17490600-4 2007 ADP production is concomitant with Raf-mediated phosphorylation of MEK. Adenosine Diphosphate 0-3 mitogen-activated protein kinase kinase 7 Homo sapiens 67-70 17482796-9 2007 In PDE3B KO mice, inhibition of collagen- and ADP-induced platelet aggregation was similar to that in WT mice. Adenosine Diphosphate 46-49 phosphodiesterase 3B, cGMP-inhibited Mus musculus 3-8 17538023-9 2007 AtCAP1 has equivalent affinities for ADP- and ATP-monomeric actin (Kd approximately 1.3 microM). Adenosine Diphosphate 37-40 cyclase associated protein 1 Arabidopsis thaliana 0-6 17698003-3 2007 We report here the crystal structures of human NRK1 in a binary complex with the reaction product nicotinamide mononucleotide (NMN) at 1.5 A resolution and in a ternary complex with ADP and tiazofurin at 2.7 A resolution. Adenosine Diphosphate 182-185 nicotinamide riboside kinase 1 Homo sapiens 47-51 17412886-3 2007 For patients in advanced phase (AdP), a higher expression of both PR3 and ELA2 in CD34(+) progenitors before SCT was associated with a lower incidence of relapse-related death, improved leukemia-free survival (LFS), and overall survival (OS); in chronic phase patients, no differences were observed. Adenosine Diphosphate 32-35 CD34 molecule Homo sapiens 82-86 17636193-0 2007 Preliminary study showing the relationship between platelet fibronectin, sialic acid, and ADP-induced aggregation levels in coronary heart disease. Adenosine Diphosphate 90-93 fibronectin 1 Homo sapiens 60-71 17478526-10 2007 The non-hydrolysable ADP analogue, ADPbetaS, acting at P2Y1 receptors, caused robust local and spreading dilatation responses whether applied to the luminal or abluminal surface of pressurized arteries. Adenosine Diphosphate 21-24 purinergic receptor P2Y1 Rattus norvegicus 55-59 17548820-2 2007 In a study that directly measures properties of internally strained myosin 2 heads bound to actin, we find that human nonmuscle myosins 2A and 2B show marked load-dependent changes in kinetics of ADP release but not in nucleotide binding. Adenosine Diphosphate 196-199 myosin heavy chain 2 Homo sapiens 68-76 17311891-2 2007 Channels comprised of Kir6.2 and SUR1 subunits function in subpopulations of mediobasal hypothalamic (MBH) neurons as an essential component of a glucose-sensing mechanism in these cells, wherein uptake and metabolism of glucose leads to increase in intracellular ATP/ADP, closure of the channels, and increase in neuronal excitability. Adenosine Diphosphate 268-271 ATP binding cassette subfamily C member 8 Rattus norvegicus 33-37 17298299-5 2007 However, blockade of either P2Y1 or the P2Y12 receptors with corresponding antagonists completely abolished ERK phosphorylation, indicating that both P2Y receptors are required for ADP-induced ERK activation. Adenosine Diphosphate 181-184 mitogen-activated protein kinase 1 Homo sapiens 108-111 17298299-5 2007 However, blockade of either P2Y1 or the P2Y12 receptors with corresponding antagonists completely abolished ERK phosphorylation, indicating that both P2Y receptors are required for ADP-induced ERK activation. Adenosine Diphosphate 181-184 mitogen-activated protein kinase 1 Homo sapiens 193-196 17298299-6 2007 Inhibitors of Src family kinases or the ERK upstream kinase MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] abrogated ADP-induced ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 127-130 mitogen-activated protein kinase 1 Homo sapiens 40-43 17298299-6 2007 Inhibitors of Src family kinases or the ERK upstream kinase MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] abrogated ADP-induced ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 127-130 mitogen-activated protein kinase kinase 7 Homo sapiens 60-63 17298299-6 2007 Inhibitors of Src family kinases or the ERK upstream kinase MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] abrogated ADP-induced ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 127-130 mitogen-activated protein kinase 1 Homo sapiens 65-69 17298299-6 2007 Inhibitors of Src family kinases or the ERK upstream kinase MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] abrogated ADP-induced ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 127-130 mitogen-activated protein kinase 1 Homo sapiens 105-108 17298299-6 2007 Inhibitors of Src family kinases or the ERK upstream kinase MEK [MAPK (mitogen-activated protein kinase)/ERK kinase] abrogated ADP-induced ERK phosphorylation and thromboxane A2 generation. Adenosine Diphosphate 127-130 mitogen-activated protein kinase 1 Homo sapiens 105-108 17298299-7 2007 Finally ADP- or G(i)+G(z)-induced ERK phosphorylation was blocked in the presence of extracellular calcium. Adenosine Diphosphate 8-11 mitogen-activated protein kinase 1 Homo sapiens 34-37 17298299-8 2007 The present studies show that ERK2 is activated downstream of P2Y receptors through a complex mechanism involving Src kinases and this plays an important role in ADP-induced thromboxane A2 generation. Adenosine Diphosphate 162-165 mitogen-activated protein kinase 1 Homo sapiens 30-34 17298299-9 2007 We also conclude that extracellular calcium blocks ADP-induced thromboxane A2 generation through the inhibition of ERK activation. Adenosine Diphosphate 51-54 mitogen-activated protein kinase 1 Homo sapiens 115-118 17317746-7 2007 Thus, our data present evidence for a dendritic segregation of Kv1-like channels in CA1 pyramidal neurons and identify a novel action for these channels, showing that they inhibit action potential bursting by restricting the size of the ADP. Adenosine Diphosphate 237-240 potassium voltage-gated channel subfamily A member 5 Rattus norvegicus 63-66 17562699-1 2007 Physiological studies on the Brittle1 maize mutant have provided circumstantial evidence that ZmBT1 (Zea mays Brittle1 protein) is involved in the ADP-Glc transport into maize endosperm plastids, but up to now, no direct ADP-Glc transport mediated by ZmBT1 has ever been shown. Adenosine Diphosphate 147-150 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 94-99 17562699-1 2007 Physiological studies on the Brittle1 maize mutant have provided circumstantial evidence that ZmBT1 (Zea mays Brittle1 protein) is involved in the ADP-Glc transport into maize endosperm plastids, but up to now, no direct ADP-Glc transport mediated by ZmBT1 has ever been shown. Adenosine Diphosphate 147-150 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 251-256 17562699-1 2007 Physiological studies on the Brittle1 maize mutant have provided circumstantial evidence that ZmBT1 (Zea mays Brittle1 protein) is involved in the ADP-Glc transport into maize endosperm plastids, but up to now, no direct ADP-Glc transport mediated by ZmBT1 has ever been shown. Adenosine Diphosphate 221-224 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 94-99 17562699-3 2007 ZmBT1 transports ADP-Glc in counterexchange with ADP with apparent affinities of about 850 and 465 mum, respectively. Adenosine Diphosphate 17-20 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 0-5 17562699-3 2007 ZmBT1 transports ADP-Glc in counterexchange with ADP with apparent affinities of about 850 and 465 mum, respectively. Adenosine Diphosphate 49-52 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 0-5 17562699-16 2007 The first group comprises BT1 orthologues restricted to cereals where they mediate the ADP-Glc transport into cereal endosperm storage plastids during starch synthesis. Adenosine Diphosphate 87-90 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 26-29 17526733-6 2007 Thus, CT-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease. Adenosine Diphosphate 19-22 ADP-ribosylarginine hydrolase Mus musculus 76-81 17259168-7 2007 In the E2(CPA) structure, ADP is bound in a distinct orientation within the nucleotide binding pocket. Adenosine Diphosphate 26-29 carboxypeptidase A1 Homo sapiens 7-14 17188026-3 2007 ADP-ribose polymers are rapidly catabolized into free ADP-ribose units by poly(ADP-ribose) glycohydrolase (PARG). Adenosine Diphosphate 0-3 poly(ADP-ribose) glycohydrolase Homo sapiens 107-111 17284517-5 2007 The wound-induced rapid activation of phosphatidylinositol-3-kinase (PI3K) and extracellular signal-regulated kinase (ERK) pathways in HCE cells was attenuated by eliminating extracellular ATP, ADP and adenosine. Adenosine Diphosphate 194-197 mitogen-activated protein kinase 1 Homo sapiens 79-116 17284517-5 2007 The wound-induced rapid activation of phosphatidylinositol-3-kinase (PI3K) and extracellular signal-regulated kinase (ERK) pathways in HCE cells was attenuated by eliminating extracellular ATP, ADP and adenosine. Adenosine Diphosphate 194-197 mitogen-activated protein kinase 1 Homo sapiens 118-121 17200114-4 2007 Although both PAR1-AP and PAR4-AP induced ADP secretion, which is required for platelet spreading, only PAR4-AP induced sustained Ca(2+) mobilization. Adenosine Diphosphate 42-45 coagulation factor II thrombin receptor Homo sapiens 14-18 17200114-6 2007 p38 phosphorylation was dependent on ADP signaling through P2Y12, its receptor. Adenosine Diphosphate 37-40 mitogen-activated protein kinase 1 Homo sapiens 0-3 17277084-10 2007 Combined, these data suggest that ATP versus ADP binding functions as a molecular switch that is flipped by cleavage of PBS1. Adenosine Diphosphate 45-48 Protein kinase superfamily protein Arabidopsis thaliana 120-124 17279620-7 2007 An ion-pair interaction in the AAC thought to be central to the mechanism of membrane penetration by ADP is predicted by this homology model to be replaced by a pi-cation interaction in MFT orthologues and probably also in other members of the family bearing the P(I/L)W motif. Adenosine Diphosphate 101-104 solute carrier family 25 member 32 Homo sapiens 186-189 17242290-0 2007 Letter by Kronish et al regarding article, "Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance". Adenosine Diphosphate 105-126 prostaglandin-endoperoxide synthase 1 Homo sapiens 141-157 16777115-6 2007 On agonist stimulation with either ADP or thrombin critical limb ischaemics demonstrated greater platelet reactivity and propensity to express CD154 compared to age-matched controls (P<0.05). Adenosine Diphosphate 35-38 CD40 ligand Homo sapiens 143-148 17259392-4 2007 In patients with diabetes, platelet stimulation with thrombin caused about two times greater release of ATP and ADP than in the healthy group while decreasing intraplatelet nucleotide content to similar levels in both groups. Adenosine Diphosphate 112-115 coagulation factor II, thrombin Homo sapiens 53-61 17263456-4 2007 Collagen and thrombin, platelet aggregatory agents that can cause the release of AA by platelets, enhanced baicalein-induced hydroxyl radical formation, whereas ADP and U44619 showed no significant effects. Adenosine Diphosphate 161-164 coagulation factor II, thrombin Homo sapiens 13-21 16985256-5 2007 ADP inhibited both AMPK and LKB1-STRAD-MO25 actions, but probably is not important physiologically because of the low free ADP inside the muscle fiber. Adenosine Diphosphate 0-3 serine/threonine kinase 11 Mus musculus 28-32 17365852-7 2007 We demonstrated that TGF-beta1 did not trigger platelet aggregation by itself but had a modulating effect on ADP-induced platelet aggregation. Adenosine Diphosphate 109-112 transforming growth factor beta 1 Homo sapiens 21-30 17242290-0 2007 Letter by Kronish et al regarding article, "Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: a 700-patient study of aspirin resistance". Adenosine Diphosphate 105-126 prostaglandin-endoperoxide synthase 2 Homo sapiens 163-179 16939417-5 2007 Depletion of the DTS using ADP, which releases Ca2+ solely from the DTS, in combination with 10 nM TG, to selectively inhibit SERCA2 located on the DTS reduced Ca2+ release evoked by the PAR-1 agonist, SFLLRN, and the PAR-4 agonist, AYPGKF, by 80 and 50% respectively. Adenosine Diphosphate 27-30 coagulation factor II thrombin receptor Homo sapiens 187-192 16990590-0 2007 Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Adenosine Diphosphate 73-76 coagulation factor II, thrombin Homo sapiens 0-8 16990590-0 2007 Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Adenosine Diphosphate 73-76 mitogen-activated protein kinase 14 Homo sapiens 24-38 16990590-4 2007 Here, we show that ADP secreted from platelet-dense granules, and subsequent activation of P2Y12 receptors, as well as TxA2 release are important upstream mediators of p38 MAP kinase activation by thrombin. Adenosine Diphosphate 19-22 mitogen-activated protein kinase 14 Homo sapiens 168-171 16990590-4 2007 Here, we show that ADP secreted from platelet-dense granules, and subsequent activation of P2Y12 receptors, as well as TxA2 release are important upstream mediators of p38 MAP kinase activation by thrombin. Adenosine Diphosphate 19-22 coagulation factor II, thrombin Homo sapiens 197-205 17202259-3 2007 Here we report the 2.4 A resolution crystal structure of FliI in the ADP-bound form. Adenosine Diphosphate 69-72 FLII actin remodeling protein Homo sapiens 57-61 16857990-7 2006 In weaver mouse platelets, which have dysfunctional GIRK2 subunits, ADP-induced TXA2 generation was impaired. Adenosine Diphosphate 68-71 potassium inwardly-rectifying channel, subfamily J, member 6 Mus musculus 52-57 16889625-7 2007 MALDI-MS and site-directed mutagenesis studies determined that ExoS ADP-ribosylated moesin at three C-terminal arginines (Arg553, Arg560 and Arg563), which cluster Thr558, the site of phosphorylation by protein kinase C and Rho kinase. Adenosine Diphosphate 68-71 moesin Homo sapiens 84-90 17063360-7 2007 The maximal myosin-ATPase activity was reduced in TGR(mREN2)27 compared to SPDR, respectively (211.0 +/- 28.77 micromol ADP/s vs. 271.6 +/- 43.66 micromol ADP/s, P < 0.05). Adenosine Diphosphate 120-123 thioredoxin reductase 3 Mus musculus 50-53 17063360-7 2007 The maximal myosin-ATPase activity was reduced in TGR(mREN2)27 compared to SPDR, respectively (211.0 +/- 28.77 micromol ADP/s vs. 271.6 +/- 43.66 micromol ADP/s, P < 0.05). Adenosine Diphosphate 155-158 thioredoxin reductase 3 Mus musculus 50-53 17573283-7 2007 The average CVs for all the release tests were greater than 30%; with 5 and 10 muM adenosine diphosphate, 56% and 42%, respectively. Adenosine Diphosphate 83-104 latexin Homo sapiens 79-82 17365660-4 2007 This factor is called the retinal relaxing factor (RRF) and its characteristics do not correspond with those of the many well-known vasorelaxants found in retina (i.e., NO, prostanoids, adenosine, ADP, ATP, lactate, glutamate, GABA, taurine, adrenomedullin, CGRP, ANP, BNP, and CNP). Adenosine Diphosphate 197-200 mitochondrial ribosome recycling factor Rattus norvegicus 51-54 17991682-5 2007 Long ADP-ribose chains (55-mer) promoted the formation of three specific complexes with p53. Adenosine Diphosphate 5-8 tumor protein p53 Homo sapiens 88-91 16860375-6 2007 Further, RGDS reduced platelet binding of (125)I-labelled fibrinogen IC-50"s of 35.5+/-3.2 (mean+/-SEM) and 20.7+/-2.2 microM for collagen- and ADP-stimulation respectively. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 58-68 16860375-8 2007 Additionally, PAC-1 reduced platelet bound of (125)I-labelled fibrinogen with IC-50"s of 9.0+/-1.4 and 4.1+/-2.2 microg/10(8) platelets for collagen- and ADP-stimulation respectively. Adenosine Diphosphate 154-157 fibrinogen beta chain Homo sapiens 62-72 17306868-8 2007 RESULTS AND CONCLUSIONS: ADP and thrombin induced similar strong levels of aggregation ( approximately 70%) at high shear by 5 s. Thrombin also caused release of about 40% of all alpha and dense granules within 5 s. However, by 5 s at high shear, ADP failed to induce significant granule secretion or thromboxane A(2) formation (<5%, p>0.05). Adenosine Diphosphate 25-28 coagulation factor II, thrombin Homo sapiens 130-138 17306868-8 2007 RESULTS AND CONCLUSIONS: ADP and thrombin induced similar strong levels of aggregation ( approximately 70%) at high shear by 5 s. Thrombin also caused release of about 40% of all alpha and dense granules within 5 s. However, by 5 s at high shear, ADP failed to induce significant granule secretion or thromboxane A(2) formation (<5%, p>0.05). Adenosine Diphosphate 247-250 coagulation factor II, thrombin Homo sapiens 33-41 17306868-8 2007 RESULTS AND CONCLUSIONS: ADP and thrombin induced similar strong levels of aggregation ( approximately 70%) at high shear by 5 s. Thrombin also caused release of about 40% of all alpha and dense granules within 5 s. However, by 5 s at high shear, ADP failed to induce significant granule secretion or thromboxane A(2) formation (<5%, p>0.05). Adenosine Diphosphate 247-250 coagulation factor II, thrombin Homo sapiens 130-138 17343900-6 2007 ANGII, in all tested doses (5, 50, 500 and 5000 pmol), was able to increase ATP (21, 31, 44 and 27%, respectively), ADP (22, 28, 78 and 37%, respectively) and AMP (40, 64, 60 and 64%, respectively) hydrolysis by rat platelets. Adenosine Diphosphate 116-119 angiotensinogen Rattus norvegicus 0-5 17176086-6 2006 Binding of AS-2 to CENP-E also stimulates the ADP release from the nucleotide-binding pocket. Adenosine Diphosphate 46-49 centromere protein E Homo sapiens 19-25 17060327-4 2006 The crystal structure of the hexamer is formed of ADP-bound RuvBL1 monomers. Adenosine Diphosphate 50-53 RuvB like AAA ATPase 1 Homo sapiens 60-66 17060327-9 2006 The structure of the RuvBL1.ADP complex, combined with our biochemical results, suggest that although RuvBL1 has all the structural characteristics of a molecular motor, even of an ATP-driven helicase, one or more as yet undetermined cofactors are needed for its enzymatic activity. Adenosine Diphosphate 28-31 RuvB like AAA ATPase 1 Homo sapiens 21-27 17060327-9 2006 The structure of the RuvBL1.ADP complex, combined with our biochemical results, suggest that although RuvBL1 has all the structural characteristics of a molecular motor, even of an ATP-driven helicase, one or more as yet undetermined cofactors are needed for its enzymatic activity. Adenosine Diphosphate 28-31 RuvB like AAA ATPase 1 Homo sapiens 102-108 17313817-0 2006 [Role of adenosine diphosphate in the course of thrombin signal transmission]. Adenosine Diphosphate 9-30 coagulation factor II, thrombin Homo sapiens 48-56 17313817-1 2006 OBJECTIVE: To study the effects adenosine diphosphate (ADP) on platelet aggregation and expression of glycoprotein (GP) on the surface of platelet membrane after activation of thrombin receptors, so as to investigate its role in thrombin signal transmission. Adenosine Diphosphate 55-58 coagulation factor II, thrombin Homo sapiens 176-184 17313817-1 2006 OBJECTIVE: To study the effects adenosine diphosphate (ADP) on platelet aggregation and expression of glycoprotein (GP) on the surface of platelet membrane after activation of thrombin receptors, so as to investigate its role in thrombin signal transmission. Adenosine Diphosphate 55-58 coagulation factor II, thrombin Homo sapiens 229-237 17313817-12 2006 CONCLUSION: ADP plays an important role in the thrombin signal transmission, especially in the PAR1 pathway. Adenosine Diphosphate 12-15 coagulation factor II, thrombin Homo sapiens 47-55 17313817-12 2006 CONCLUSION: ADP plays an important role in the thrombin signal transmission, especially in the PAR1 pathway. Adenosine Diphosphate 12-15 coagulation factor II thrombin receptor Homo sapiens 95-99 17161243-4 2006 Platelet aggregation (5 and 20 muM adenosine diphosphate [ADP]), ADP-stimulated expression of active glycoprotein (GP) IIb/IIIa, and platelet-bound P-selectin, tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), and cardiac markers were measured. Adenosine Diphosphate 65-68 tumor necrosis factor Homo sapiens 160-193 17161243-4 2006 Platelet aggregation (5 and 20 muM adenosine diphosphate [ADP]), ADP-stimulated expression of active glycoprotein (GP) IIb/IIIa, and platelet-bound P-selectin, tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), and cardiac markers were measured. Adenosine Diphosphate 65-68 C-reactive protein Homo sapiens 195-213 17161243-4 2006 Platelet aggregation (5 and 20 muM adenosine diphosphate [ADP]), ADP-stimulated expression of active glycoprotein (GP) IIb/IIIa, and platelet-bound P-selectin, tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), and cardiac markers were measured. Adenosine Diphosphate 65-68 C-reactive protein Homo sapiens 215-218 17139575-3 2006 Changes in the ATP/ADP ratio within the beta cells will then trigger the release of insulin granules from them. Adenosine Diphosphate 19-22 insulin Homo sapiens 84-91 17127486-9 2006 Upon stimulation with ADP and SFLLRN, monocyte-platelet and neutrophil-platelet aggregates, platelet CD40L and P-selectin, and monocyte TF increased compared to the resting state but was not different between 0 and 24 h, indicating that the responsiveness to those agonists was not altered. Adenosine Diphosphate 22-25 CD40 ligand Homo sapiens 101-106 17085600-7 2006 Otherwise, as in Drosophila embryonic muscle and other slow muscle types, a step associated with MgADP release limits muscle contraction speed by delaying the detachment of myosin from actin. Adenosine Diphosphate 97-102 Actin 79B Drosophila melanogaster 185-190 16931513-7 2006 Furthermore, we identified the site of ADP-ribose polymer attachment on ART2 as Arg-185, an arginine in a crucial loop of its catalytic core. Adenosine Diphosphate 39-42 ADP-ribosyltransferase 2b Rattus norvegicus 72-76 16931513-8 2006 We found that endogenous ART2 on IELs undergoes multimeric auto-ADP-ribosylation more efficiently than ART2 on peripheral T cells, suggesting that these distinct lymphocyte populations differ in their ART2 surface topology. Adenosine Diphosphate 64-67 ADP-ribosyltransferase 2b Rattus norvegicus 25-29 17365852-10 2007 Besides, TGF-beta1 modified the pattern of ADP-induced tyrosine phosphorylation. Adenosine Diphosphate 43-46 transforming growth factor beta 1 Homo sapiens 9-18 17103109-1 2006 We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ecto-F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13)-mediated high-density lipoprotein (HDL) endocytosis pathway. Adenosine Diphosphate 151-154 apolipoprotein A1 Homo sapiens 58-76 16980436-5 2006 RINm5F-GK-PFK-2/FBPase-2 cells showed under this culture condition a significant increase in glucose utilization and in the ATP/ADP ratio compared with RINm5F-GK cells, which only overexpress glucokinase. Adenosine Diphosphate 128-131 fructose-bisphosphatase 2 Rattus norvegicus 16-24 17158748-9 2006 Upon heat shock, the Hsp70.1 promoter-bound PARP-1 is released to activate transcription through ADP-ribosylation of other Hsp70.1 promoter-bound proteins. Adenosine Diphosphate 97-100 heat shock protein family A (Hsp70) member 1A Homo sapiens 21-28 17158748-9 2006 Upon heat shock, the Hsp70.1 promoter-bound PARP-1 is released to activate transcription through ADP-ribosylation of other Hsp70.1 promoter-bound proteins. Adenosine Diphosphate 97-100 poly(ADP-ribose) polymerase 1 Homo sapiens 44-50 17158748-9 2006 Upon heat shock, the Hsp70.1 promoter-bound PARP-1 is released to activate transcription through ADP-ribosylation of other Hsp70.1 promoter-bound proteins. Adenosine Diphosphate 97-100 heat shock protein family A (Hsp70) member 1A Homo sapiens 123-130 17100655-10 2006 CONCLUSIONS: We demonstrate that VWF activates eNOS through a specific Ca2+-dependent GPIb receptor-signaling cascade that relies on the generation of platelet-derived ADP and TxA2. Adenosine Diphosphate 168-171 von Willebrand factor Homo sapiens 33-36 17052202-12 2006 UCP2 knockout mice were protected from the diabetogenic effects of a high-fat diet and their islets exhibited increased sensitivity to glucose and elevated ATP/ADP. Adenosine Diphosphate 160-163 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 0-4 17146552-9 2006 Furthermore, the calmodulin-binding domain found in eukaryotic HSP70s is also the target for binding of Bag-1 - an enhancer of ADP/ATP exchange activity of Hsp70s. Adenosine Diphosphate 127-130 calmodulin Saccharomyces cerevisiae S288C 17-27 17111306-0 2006 Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression. Adenosine Diphosphate 76-79 prolactin Homo sapiens 10-19 17111306-1 2006 Prolactin and leptin are newly recognized platelet co-stimulators due to enhancement of ADP-induced platelet aggregation. Adenosine Diphosphate 88-91 prolactin Homo sapiens 0-9 17111306-6 2006 In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r (2)=0.41; p=0.025), whereas leptin was not correlated. Adenosine Diphosphate 91-94 prolactin Homo sapiens 38-47 16741143-5 2006 Addition of exogenous cytochrome c increased ADP-dependent respiration, and the large-scale cytochrome c effect (>or=20%) was associated with suppressed stimulation of respiration by creatine and AMP in the mucosal preparations. Adenosine Diphosphate 45-48 cytochrome c, somatic Homo sapiens 22-34 17015835-4 2006 Here, we report the crystal structure of Staphylococcus aureus DDl (StaDDl) and its cocrystal structures with 3-chloro-2,2-dimethyl-N-[4(trifluoromethyl)phenyl]propanamide (inhibitor 1) (Ki=4 microM against StaDDl) and with ADP, one of the reaction products, at resolutions of 2.0, 2.2, and 2.6 A, respectively. Adenosine Diphosphate 224-227 AT695_RS07115 Staphylococcus aureus 63-66 17067301-9 2006 The present data suggest that ATP/ADP, acting as extracellular signal molecules in the rat brain, are involved in the regulation of food intake, possibly depending on P2Y1-receptor-mediated nitric oxide production. Adenosine Diphosphate 34-37 purinergic receptor P2Y1 Rattus norvegicus 167-171 16617125-3 2006 In isolated mitochondria without exogenous substrates, addition of catalase and the membrane-permeant reducing agent N-acetylcysteine (Nac) or the ROS scavenger mercaptopropionyl glycine significantly increased the ability to phosphorylate added ADP, as demonstrated by 1) full recovery of membrane potential (Deltapsi) and matrix volume from ADP-induced dissipation and shrinkage, 2) ADP-dependent increase in O2 consumption, and 3) enhanced rate of ATP synthesis. Adenosine Diphosphate 343-346 catalase Homo sapiens 67-75 16617125-3 2006 In isolated mitochondria without exogenous substrates, addition of catalase and the membrane-permeant reducing agent N-acetylcysteine (Nac) or the ROS scavenger mercaptopropionyl glycine significantly increased the ability to phosphorylate added ADP, as demonstrated by 1) full recovery of membrane potential (Deltapsi) and matrix volume from ADP-induced dissipation and shrinkage, 2) ADP-dependent increase in O2 consumption, and 3) enhanced rate of ATP synthesis. Adenosine Diphosphate 343-346 catalase Homo sapiens 67-75 16946495-7 2006 In contrast, ALDRP exhibited an affinity to ADP but scarcely to ATP. Adenosine Diphosphate 44-47 ATP binding cassette subfamily D member 2 Homo sapiens 13-18 16804093-8 2006 ADP-induced P2Y1 receptor internalization is attenuated by PKC inhibitors, whereas that of the P2Y12 receptor is unaffected. Adenosine Diphosphate 0-3 protein kinase C alpha Homo sapiens 59-62 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 383-386 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 15-20 16978538-1 2006 To analyze immune response to murine hepatocarcinoma Hca-F of mice immunized with heat shock protein 70 (HSP70) derived from elemene combo tumor cell vaccine (EC-TCV) of Hca-F, HSP70 was isolated from EC-TCV by ADP affinity chromatography. Adenosine Diphosphate 211-214 heat shock protein 1B Mus musculus 105-110 16617125-3 2006 In isolated mitochondria without exogenous substrates, addition of catalase and the membrane-permeant reducing agent N-acetylcysteine (Nac) or the ROS scavenger mercaptopropionyl glycine significantly increased the ability to phosphorylate added ADP, as demonstrated by 1) full recovery of membrane potential (Deltapsi) and matrix volume from ADP-induced dissipation and shrinkage, 2) ADP-dependent increase in O2 consumption, and 3) enhanced rate of ATP synthesis. Adenosine Diphosphate 246-249 catalase Homo sapiens 67-75 17015265-0 2006 The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Adenosine Diphosphate 4-7 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 47-52 16943556-2 2006 We showed previously that repetitive stimulation of nicotinic acetylcholine receptor (nAChR) induced activity-dependent potentiation (ADP) of large dense-core vesicle (LDCV) exocytosis in chromaffin cells. Adenosine Diphosphate 134-137 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 52-84 16943556-2 2006 We showed previously that repetitive stimulation of nicotinic acetylcholine receptor (nAChR) induced activity-dependent potentiation (ADP) of large dense-core vesicle (LDCV) exocytosis in chromaffin cells. Adenosine Diphosphate 134-137 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 86-91 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 223-226 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 15-20 16820608-6 2006 The CHOL group demonstrated impaired microvessel relaxation to adenosine diphosphate (29+/-3% versus 61+/-6%, CHOL versus NORM; P<0.05), which was normalized in the CHOL-ATR group (67+/-2%; P=NS versus NORM). Adenosine Diphosphate 63-84 CHOL Sus scrofa 4-8 16843179-11 2006 Insulin treatment was the strongest predictor of ADP-induced aggregation. Adenosine Diphosphate 49-52 insulin Homo sapiens 0-7 16800628-9 2006 Using established methods involving ADP-Vi trapping by wild-type Pgp and ATP binding by catalytic carboxylate mutant Pgp, these effects can be extended to ATP hydrolysis transition-state stabilization and ATP occlusion at a single site. Adenosine Diphosphate 36-39 ATP binding cassette subfamily B member 1 Homo sapiens 65-68 16800628-9 2006 Using established methods involving ADP-Vi trapping by wild-type Pgp and ATP binding by catalytic carboxylate mutant Pgp, these effects can be extended to ATP hydrolysis transition-state stabilization and ATP occlusion at a single site. Adenosine Diphosphate 36-39 ATP binding cassette subfamily B member 1 Homo sapiens 117-120 16734458-3 2006 Here we report the identification and characterization of a Thi4-bound metabolite that consists of the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid. Adenosine Diphosphate 103-106 thiamine thiazole synthase Saccharomyces cerevisiae S288C 60-64 16781456-3 2006 Here, we show that, in the rat alveolar macrophage NR8383 cell line, H(2)O(2) produced through the ADP-stimulated respiratory burst induces the formation of a disulfide bond between PTP1B and GSH that was detectable with an antibody to glutathione-protein complexes and was reversed by DTT addition. Adenosine Diphosphate 99-102 protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus 182-187 16781456-4 2006 PTP1B glutathionylation was dependent on H(2)O(2) as the presence of catalase at the time of ADP stimulation inhibited the formation of the conjugate. Adenosine Diphosphate 93-96 protein tyrosine phosphatase, non-receptor type 1 Rattus norvegicus 0-5 16781456-4 2006 PTP1B glutathionylation was dependent on H(2)O(2) as the presence of catalase at the time of ADP stimulation inhibited the formation of the conjugate. Adenosine Diphosphate 93-96 catalase Rattus norvegicus 69-77 16807649-1 2006 Prolactin and leptin are newly recognised platelet co-stimulators due to potentiation of ADP-induced platelet aggregation. Adenosine Diphosphate 89-92 prolactin Homo sapiens 0-9 16807649-4 2006 We determined plasma prolactin and leptin levels as well as platelet P-selectin expression in 36 patients with ischemic stroke or transient ischemic attack and detected a significant correlation between increased prolactin values and enhanced ADP stimulated P-selectin expression on platelets. Adenosine Diphosphate 243-246 prolactin Homo sapiens 21-30 16807649-4 2006 We determined plasma prolactin and leptin levels as well as platelet P-selectin expression in 36 patients with ischemic stroke or transient ischemic attack and detected a significant correlation between increased prolactin values and enhanced ADP stimulated P-selectin expression on platelets. Adenosine Diphosphate 243-246 prolactin Homo sapiens 213-222 16696949-3 2006 PPDK regulatory protein (RP), a bifunctional serine/threonine kinase-phosphatase, catalyzes both the ADP-dependent inactivation and the Pi-dependent activation of PPDK. Adenosine Diphosphate 101-104 pyruvate, phosphate dikinase regulatory protein, chloroplastic Zea mays 0-23 16584705-8 2006 In addition, we demonstrate that ADP competitively inhibits phosphorylation of HDAC5 (K(i)=8.50, 17.54, and 11.98microM for PKD1, PKD2, and PKD3, respectively). Adenosine Diphosphate 33-36 histone deacetylase 5 Homo sapiens 79-84 16584705-8 2006 In addition, we demonstrate that ADP competitively inhibits phosphorylation of HDAC5 (K(i)=8.50, 17.54, and 11.98microM for PKD1, PKD2, and PKD3, respectively). Adenosine Diphosphate 33-36 polycystin 2, transient receptor potential cation channel Homo sapiens 130-134 17015265-2 2006 We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1). Adenosine Diphosphate 23-26 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 248-284 17015265-2 2006 We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1). Adenosine Diphosphate 23-26 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 286-290 17015265-4 2006 ADP induced the dissociation of ASK1/Trx complex and thus resulted in ASK1 activation, as assessed by phosphorylation at Thr845, which was enhanced after treatment with aurothioglucose (ATG), an inhibitor of Trx reductase. Adenosine Diphosphate 0-3 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 32-36 17015265-4 2006 ADP induced the dissociation of ASK1/Trx complex and thus resulted in ASK1 activation, as assessed by phosphorylation at Thr845, which was enhanced after treatment with aurothioglucose (ATG), an inhibitor of Trx reductase. Adenosine Diphosphate 0-3 thioredoxin 1 Rattus norvegicus 37-40 17015265-4 2006 ADP induced the dissociation of ASK1/Trx complex and thus resulted in ASK1 activation, as assessed by phosphorylation at Thr845, which was enhanced after treatment with aurothioglucose (ATG), an inhibitor of Trx reductase. Adenosine Diphosphate 0-3 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 70-74 17015265-4 2006 ADP induced the dissociation of ASK1/Trx complex and thus resulted in ASK1 activation, as assessed by phosphorylation at Thr845, which was enhanced after treatment with aurothioglucose (ATG), an inhibitor of Trx reductase. Adenosine Diphosphate 0-3 thioredoxin 1 Rattus norvegicus 208-211 17015265-6 2006 These results demonstrate that the ADP-stimulated respiratory burst activated the ASK1-MKK4-JNK1/c-Jun signaling pathway in AM and suggest that transient and localized oxidation of Trx by the NADPH oxidase-mediated generation of H2O2 may play a critical role in ASK1 activation and the inflammatory response. Adenosine Diphosphate 35-38 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 82-86 17015265-6 2006 These results demonstrate that the ADP-stimulated respiratory burst activated the ASK1-MKK4-JNK1/c-Jun signaling pathway in AM and suggest that transient and localized oxidation of Trx by the NADPH oxidase-mediated generation of H2O2 may play a critical role in ASK1 activation and the inflammatory response. Adenosine Diphosphate 35-38 thioredoxin 1 Rattus norvegicus 181-184 17015265-6 2006 These results demonstrate that the ADP-stimulated respiratory burst activated the ASK1-MKK4-JNK1/c-Jun signaling pathway in AM and suggest that transient and localized oxidation of Trx by the NADPH oxidase-mediated generation of H2O2 may play a critical role in ASK1 activation and the inflammatory response. Adenosine Diphosphate 35-38 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 262-266 16549375-6 2006 METHODS: Platelet activation was measured using whole-blood flow cytometric measurement of ADP-stimulated fibrinogen binding at baseline and 12h after administration of a loading dose of 300 mg clopidogrel. Adenosine Diphosphate 91-94 fibrinogen beta chain Homo sapiens 106-116 16627471-14 2006 We conclude that ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease. Adenosine Diphosphate 17-20 ADP-ribosyltransferase 1 Homo sapiens 82-86 16688212-2 2006 Hsp40s increase the low intrinsic ATPase activity of Hsp70, and nucleotide exchange factors (NEFs) remove ADP after ATP hydrolysis, enabling a new Hsp70 interaction cycle with non-native protein substrate. Adenosine Diphosphate 106-109 type I HSP40 co-chaperone YDJ1 Saccharomyces cerevisiae S288C 0-5 18404476-5 2006 The enzymatic action of NPP1-3 (in)directly results in the termination of nucleotide signaling, the salvage of nucleotides and/or the generation of new messengers like ADP, adenosine or pyrophosphate. Adenosine Diphosphate 168-171 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 24-30 16672190-2 2006 The activities of ecto-nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) and ecto 5"-nucleotidase were assessed by measuring the levels of ATP, ADP and AMP hydrolysis in the crude membrane preparations obtained from injured left cortex, right cortex, left and right caudate nucleus, whole hippocampus and cerebellum. Adenosine Diphosphate 151-154 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 18-67 16672190-2 2006 The activities of ecto-nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) and ecto 5"-nucleotidase were assessed by measuring the levels of ATP, ADP and AMP hydrolysis in the crude membrane preparations obtained from injured left cortex, right cortex, left and right caudate nucleus, whole hippocampus and cerebellum. Adenosine Diphosphate 151-154 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 69-78 16706984-4 2006 RESULTS: In the presence of botrocetin and inhibitors of adenosine diphosphate (ADP) and thromboxane A2 (TxA2), VWF is able to support formation of lamellipodia through a GPIb-dependent mechanism that is independent of alpha(IIb)beta3 and PI3-kinase. Adenosine Diphosphate 57-78 von Willebrand factor Homo sapiens 112-115 16706984-4 2006 RESULTS: In the presence of botrocetin and inhibitors of adenosine diphosphate (ADP) and thromboxane A2 (TxA2), VWF is able to support formation of lamellipodia through a GPIb-dependent mechanism that is independent of alpha(IIb)beta3 and PI3-kinase. Adenosine Diphosphate 80-83 von Willebrand factor Homo sapiens 112-115 16643864-14 2006 The data suggest that restricted feeding may enhance the sensitivity of the hypothalamus to extracellular ADP/ATP by regulation of the expression of P2Y1 receptors and possibly of their signal transduction pathway via nitric oxide production. Adenosine Diphosphate 106-109 purinergic receptor P2Y1 Rattus norvegicus 149-153 16540465-7 2006 The patterns of product inhibition of AKT1, AKT2, and AKT3 by ADP were all consistent with an ordered substrate addition mechanism with ATP binding to the enzymes prior to the peptide substrate. Adenosine Diphosphate 62-65 AKT serine/threonine kinase 1 Homo sapiens 38-42 16540465-8 2006 Further analysis of steady state kinetics of AKT1 in the presence of dead-end inhibitors supported the finding and suggested that the AKT family of kinases catalyzes reactions via an Ordered Bi Bi sequential mechanism with ATP binding to the enzyme prior to peptide substrate and ADP being released after the phosphopeptide product. Adenosine Diphosphate 280-283 AKT serine/threonine kinase 1 Homo sapiens 45-49 16540465-8 2006 Further analysis of steady state kinetics of AKT1 in the presence of dead-end inhibitors supported the finding and suggested that the AKT family of kinases catalyzes reactions via an Ordered Bi Bi sequential mechanism with ATP binding to the enzyme prior to peptide substrate and ADP being released after the phosphopeptide product. Adenosine Diphosphate 280-283 AKT serine/threonine kinase 1 Homo sapiens 45-48 16624826-4 2006 The time constant of ADP-induced endocytosis of P2Y-receptors was determined as 1.7 s. The ADP-induced endocytosis was blocked by antagonists against P2Y, phosphorylation, and clathrin. Adenosine Diphosphate 21-24 purinergic receptor P2Y1 Rattus norvegicus 48-51 16624826-4 2006 The time constant of ADP-induced endocytosis of P2Y-receptors was determined as 1.7 s. The ADP-induced endocytosis was blocked by antagonists against P2Y, phosphorylation, and clathrin. Adenosine Diphosphate 21-24 purinergic receptor P2Y1 Rattus norvegicus 150-153 16624826-4 2006 The time constant of ADP-induced endocytosis of P2Y-receptors was determined as 1.7 s. The ADP-induced endocytosis was blocked by antagonists against P2Y, phosphorylation, and clathrin. Adenosine Diphosphate 91-94 purinergic receptor P2Y1 Rattus norvegicus 48-51 16624826-4 2006 The time constant of ADP-induced endocytosis of P2Y-receptors was determined as 1.7 s. The ADP-induced endocytosis was blocked by antagonists against P2Y, phosphorylation, and clathrin. Adenosine Diphosphate 91-94 purinergic receptor P2Y1 Rattus norvegicus 150-153 16624826-7 2006 Finally, the receptors were internalized in response to ADP, as determined by GFP-labeled P2Y. Adenosine Diphosphate 56-59 purinergic receptor P2Y1 Rattus norvegicus 90-93 16300799-6 2006 Conversely, A3AR agonism (100 nM Cl-IB-MECA) did reduce effects of I/R (pEC50s=8.0+/-0.1 and 7.3+/-0.1 for 2-chloroadenosine and ADP, respectively), whereas antagonism (100 nM MRS1220) was without effect. Adenosine Diphosphate 129-132 adenosine A3 receptor Mus musculus 12-16 16549073-2 2006 We have used cryo-electron microscopy and image processing to obtain three-dimensional structures of the E.coli chaperonin GroEL complexed with gp31, in the presence of both ATP and ADP. Adenosine Diphosphate 182-185 GroEL Escherichia coli 123-128 16549073-3 2006 The GroEL-gp31-ADP map has a resolution of 8.2 A, which allows accurate fitting of the GroEL and gp31 crystal structures. Adenosine Diphosphate 15-18 GroEL Escherichia coli 4-9 16549073-3 2006 The GroEL-gp31-ADP map has a resolution of 8.2 A, which allows accurate fitting of the GroEL and gp31 crystal structures. Adenosine Diphosphate 15-18 GroEL Escherichia coli 87-92 16549073-4 2006 Comparison of this fitted structure with that of the GroEL-GroES-ADP structure previously determined by cryo-electron microscopy shows that the folding cage is expanded. Adenosine Diphosphate 65-68 GroEL Escherichia coli 53-58 16332922-5 2006 Ischemia was found to increase the ADP-to-ATP (ADP/ATP) and AMP-to-ATP ratios (AMP/ATP) to a greater extent in LKB1-deficient cardiac muscle than in LKB1-expressing muscle. Adenosine Diphosphate 35-38 serine/threonine kinase 11 Mus musculus 111-115 16520376-5 2006 Using acetyl-lysine substrate analogs, we demonstrate that the Hst2 reaction proceeds via an initial SN2-type mechanism with the direct formation of an ADP-ribose-acetyl-lysine intermediate. Adenosine Diphosphate 152-155 histone deacetylase HST2 Saccharomyces cerevisiae S288C 63-67 16418174-0 2006 The affinity of a major Ca2+ binding site on GRP78 is differentially enhanced by ADP and ATP. Adenosine Diphosphate 81-84 heat shock protein family A (Hsp70) member 5 Homo sapiens 45-50 16585515-6 2006 The kinetic basis for the processive motility of myosin VIIa is the relative magnitude of the release rate constants of phosphate (fast) and ADP (slow) as in myosins V and VI. Adenosine Diphosphate 141-144 crinkled Drosophila melanogaster 49-60 16634759-8 2006 Selective ADP receptor inhibitors attenuated P2X1-mediated priming, suggesting that the synergy between P2X1 and sub-threshold PAR1 stimulation was in part because of enhanced granular release of ADP. Adenosine Diphosphate 10-13 coagulation factor II thrombin receptor Homo sapiens 127-131 16418174-4 2006 In order to understand the potential biological effects of Ca2+ and ATP/ADP binding on the biology of GRP78, we have determined its ligand binding properties. Adenosine Diphosphate 72-75 heat shock protein family A (Hsp70) member 5 Homo sapiens 102-107 16418174-5 2006 We show here for the first time that GRP78 can bind Ca2+, ATP, and ADP, each with a 1:1 stoichiometry, and that the binding of cation and nucleotide is cooperative. Adenosine Diphosphate 67-70 heat shock protein family A (Hsp70) member 5 Homo sapiens 37-42 16418174-7 2006 Furthermore, we demonstrate that whereas Mg2+ enhances GRP78 binding to ADP and ATP to the same extent, Ca2+ shows a differential enhancement. Adenosine Diphosphate 72-75 heat shock protein family A (Hsp70) member 5 Homo sapiens 55-60 16418174-10 2006 These findings may explain the biological requirement for a nucleotide exchange factor to remove ADP from GRP78. Adenosine Diphosphate 97-100 heat shock protein family A (Hsp70) member 5 Homo sapiens 106-111 16418174-11 2006 Taken together, our data suggest that the Ca2+-binding property of GRP78 may be part of a signal transduction pathway that modulates complex interactions between GRP78, ATP/ADP, secretory proteins, and caspases, and this ultimately has important consequences for cell viability. Adenosine Diphosphate 173-176 heat shock protein family A (Hsp70) member 5 Homo sapiens 67-72 16476557-7 2006 In contrast, CD39L1/NTPDase2, a preferential nucleoside triphosphatase, activates platelets by preferentially converting ATP to ADP, the major agonist of platelet P2 receptors. Adenosine Diphosphate 128-131 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 13-19 16503665-4 2006 We confirm previous literature observations that GroEL is an Ap(4)A binding protein and go on to prove that binding of Ap(4)A to GroEL involves a set of binding sites (one per monomer) distinct from the well-known GroEL ATP/ADP sites. Adenosine Diphosphate 224-227 GroEL Escherichia coli 49-54 16503665-4 2006 We confirm previous literature observations that GroEL is an Ap(4)A binding protein and go on to prove that binding of Ap(4)A to GroEL involves a set of binding sites (one per monomer) distinct from the well-known GroEL ATP/ADP sites. Adenosine Diphosphate 224-227 GroEL Escherichia coli 129-134 16503665-4 2006 We confirm previous literature observations that GroEL is an Ap(4)A binding protein and go on to prove that binding of Ap(4)A to GroEL involves a set of binding sites (one per monomer) distinct from the well-known GroEL ATP/ADP sites. Adenosine Diphosphate 224-227 GroEL Escherichia coli 129-134 16503665-5 2006 Binding of Ap(4)A to GroEL appears to enhance ATPase rates at higher temperatures, encourages the release of bound ADP, and may promote substrate protein release through differential destabilization of the substrate protein-GroEL complex. Adenosine Diphosphate 115-118 GroEL Escherichia coli 21-26 16476557-7 2006 In contrast, CD39L1/NTPDase2, a preferential nucleoside triphosphatase, activates platelets by preferentially converting ATP to ADP, the major agonist of platelet P2 receptors. Adenosine Diphosphate 128-131 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 20-28 16507998-3 2006 Here we show that tumor necrosis factor alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport of ADP into mitochondria, which resulted in reduced ATP and necrotic cell death. Adenosine Diphosphate 142-145 tumor necrosis factor Homo sapiens 18-45 16095882-9 2006 We suggest that thrombin evokes Ca2+ release from TBHQ-sensitive and insensitive stores, which requires both NAADP and IP3, respectively, while ADP and AVP exert an IP3-dependent release of Ca2+ from the TBHQ-insensitive compartment in human platelets. Adenosine Diphosphate 111-114 coagulation factor II, thrombin Homo sapiens 16-24 16421009-7 2006 Angiotensin II (5.0 and 10 nM) affected only ADP hydrolysis. Adenosine Diphosphate 45-48 angiotensinogen Rattus norvegicus 0-14 16489767-3 2006 In this study, we demonstrate that certain thioxanthene-based Pgp modulators, such as cis-(Z)-flupentixol and its closely related analogues, effectively disrupt molecular cross talk between the substrate, and the ATP, sites without affecting the basic functional aspects of the two domains, such as substrate recognition, binding, and hydrolysis of ATP and dissociation of ADP following ATP hydrolysis. Adenosine Diphosphate 373-376 ATP binding cassette subfamily B member 1 Homo sapiens 62-65 16231090-3 2005 Stimulation of this ectopic ATP synthase by apoA-I triggered a low-affinity-receptor-dependent HDL endocytosis by a mechanism strictly related to the generation of ADP. Adenosine Diphosphate 164-167 apolipoprotein A1 Homo sapiens 44-50 16337154-2 2006 Our preliminary data suggested that PARP catalyzed ADP-ribosylations may affect signaling pathways in cardiomyocytes. Adenosine Diphosphate 51-54 poly(ADP-ribose) polymerase 1 Homo sapiens 36-40 16341234-4 2006 Short-term (5 min) pre-exposure to oxidized ATP (oATP), a P2X7 antagonist that does not inhibit P2X7-associated inward currents or membrane permeabilization, inhibits the activation of ERK1/2 by ATP, ADP, the P2X7 agonist 2"-3"-O-(4-benzoylbenzoyl)-ATP (BzATP), but not by UTP and UDP. Adenosine Diphosphate 200-203 mitogen-activated protein kinase 3 Homo sapiens 185-191 16278211-5 2006 We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Adenosine Diphosphate 71-74 poly(ADP-ribose) glycohydrolase Homo sapiens 118-122 16397294-8 2006 Ddx42p, particularly in the ADP-bound form (the state after ATP hydrolysis), also mediates efficient annealing of complementary RNA strands thereby displacing the ss binding protein. Adenosine Diphosphate 28-31 DEAD-box helicase 42 Homo sapiens 0-6 16397294-10 2006 The adenosine nucleotide cofactor bound to Ddx42p apparently acts as a switch that controls the two opposing activities: ATP triggers RNA strand separation, whereas ADP triggers annealing of complementary RNA strands. Adenosine Diphosphate 165-168 DEAD-box helicase 42 Homo sapiens 43-49 16720433-8 2006 We propose that ART2-catalyzed ADP-ribosylation of P2X7 represents the paradigm of a regulatory mechanism by which ART-expressing cells can sense and respond to the release of NAD from damaged cells. Adenosine Diphosphate 31-34 ADP-ribosyltransferase 1 Homo sapiens 16-20 16720433-8 2006 We propose that ART2-catalyzed ADP-ribosylation of P2X7 represents the paradigm of a regulatory mechanism by which ART-expressing cells can sense and respond to the release of NAD from damaged cells. Adenosine Diphosphate 31-34 purinergic receptor P2X 7 Homo sapiens 51-55 16454716-6 2006 In vitro aggregation of platelets treated with TPO and agonist, adenosine diphosphate (ADP), decrease the dose of ADP that is required for half-maximum aggregation. Adenosine Diphosphate 64-85 thrombopoietin Homo sapiens 47-50 16454716-6 2006 In vitro aggregation of platelets treated with TPO and agonist, adenosine diphosphate (ADP), decrease the dose of ADP that is required for half-maximum aggregation. Adenosine Diphosphate 87-90 thrombopoietin Homo sapiens 47-50 16454716-6 2006 In vitro aggregation of platelets treated with TPO and agonist, adenosine diphosphate (ADP), decrease the dose of ADP that is required for half-maximum aggregation. Adenosine Diphosphate 114-117 thrombopoietin Homo sapiens 47-50 16472655-2 2006 The C3 enzyme selectively catalyzes the ADP-ribosylation, and consequent inactivation, of RhoA, RhoB, and RhoC of the Rho GTPase protein family. Adenosine Diphosphate 40-43 ras homolog family member A Homo sapiens 90-94 17065073-2 2006 Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Adenosine Diphosphate 82-85 adenosine kinase Homo sapiens 212-215 17065073-2 2006 Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Adenosine Diphosphate 163-166 adenosine kinase Homo sapiens 212-215 17065073-2 2006 Here, we report new properties of rat liver enzyme, demonstrating a new reaction: ADP can be a phosphate donor instead ATP, according to the reaction: adenosine + ADP --> 2AMP) demonstrating the efficiency of AdK to phosphorylate adenosine, also starting from ADP. Adenosine Diphosphate 163-166 adenosine kinase Homo sapiens 212-215 16543975-8 2006 There was a 5-fold difference in the platelet aggregation threshold index (PATI) for ADP-induced PRP aggregation between AKR/J (0.6 microM) and DBA/2 (3.0 microM). Adenosine Diphosphate 85-88 proline rich protein HaeIII subfamily 1 Mus musculus 97-100 16223764-0 2005 High affinity ATP/ADP analogues as new tools for studying CFTR gating. Adenosine Diphosphate 18-21 CF transmembrane conductance regulator Homo sapiens 58-62 16223764-4 2005 Here we explore the possibility of using N6-modified ATP/ADP analogues as high-affinity ligands for CFTR gating, since these analogues have been shown to be more potent than native ATP/ADP in other ATP-binding proteins. Adenosine Diphosphate 57-60 CF transmembrane conductance regulator Homo sapiens 100-104 16223764-4 2005 Here we explore the possibility of using N6-modified ATP/ADP analogues as high-affinity ligands for CFTR gating, since these analogues have been shown to be more potent than native ATP/ADP in other ATP-binding proteins. Adenosine Diphosphate 185-188 CF transmembrane conductance regulator Homo sapiens 100-104 16179355-4 2005 Unlike other processive myosins, Myo9b exhibited a low affinity for ADP, and ADP release was not rate-limiting in the ATPase cycle. Adenosine Diphosphate 68-71 myosin IXb Rattus norvegicus 33-38 16445284-4 2006 The recognition and stability of the coenzyme-CPR complex are largely determined by interaction with the adenosine moiety (K(d2)(")(,5)(")(-ADP) = 76 nM), regardless of the redox state of the nicotinamide moiety. Adenosine Diphosphate 140-143 cytochrome p450 oxidoreductase Homo sapiens 46-49 16223779-8 2006 These data demonstrate that G(12/13), but not Gq, is essential for thrombin-induced Akt phosphorylation in platelets, whereas Gq indirectly contributes to Akt phosphorylation through Gi stimulation by secreted ADP. Adenosine Diphosphate 210-213 coagulation factor II, thrombin Homo sapiens 67-75 16420577-2 2006 Platelet agonists such as thrombin and adenosine diphosphate (ADP) lead to the activation of alpha(IIb)beta(3), thereby enhancing its affinity and avidity for binding fibrinogen (inside-out signaling). Adenosine Diphosphate 39-60 fibrinogen beta chain Homo sapiens 167-177 16420577-2 2006 Platelet agonists such as thrombin and adenosine diphosphate (ADP) lead to the activation of alpha(IIb)beta(3), thereby enhancing its affinity and avidity for binding fibrinogen (inside-out signaling). Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 167-177 16420577-7 2006 Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine. Adenosine Diphosphate 224-227 coagulation factor II, thrombin Homo sapiens 72-80 16420577-7 2006 Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine. Adenosine Diphosphate 224-227 coagulation factor II thrombin receptor Homo sapiens 92-121 16420577-7 2006 Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine. Adenosine Diphosphate 224-227 coagulation factor II thrombin receptor Homo sapiens 123-127 16685599-3 2006 TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Adenosine Diphosphate 241-244 tumor necrosis factor Homo sapiens 190-198 15921723-8 2006 P2Y(12) blockade was in all species equally effective as ADP removal in inhibiting thrombin-induced platelet activation whereas P2Y(1) blockade was almost ineffective. Adenosine Diphosphate 57-60 coagulation factor II Mus musculus 83-91 16182602-5 2005 ROP function is dependent on the class 1 ADP-ribosylation factors (ARFs), which are core components of the vesicle transport machinery that are also involved in the polar localization of PIN-FORMED (PIN) family auxin efflux facilitators. Adenosine Diphosphate 41-44 dynein light chain LC8-type 1 Homo sapiens 187-197 16182602-5 2005 ROP function is dependent on the class 1 ADP-ribosylation factors (ARFs), which are core components of the vesicle transport machinery that are also involved in the polar localization of PIN-FORMED (PIN) family auxin efflux facilitators. Adenosine Diphosphate 41-44 dynein light chain LC8-type 1 Homo sapiens 187-190 16186105-4 2005 The myosin VIIb steady-state ATPase activity is slow (approximately 1 s(-1)), activated by very low actin filament concentrations (K(ATPase) approximately 0.7 microm), and limited by ADP release from actomyosin. Adenosine Diphosphate 183-186 myosin VIIB Mus musculus 4-15 16186105-6 2005 ADP and actin binding is uncoupled, which enables myosin VIIb to remain strongly bound to actin and ADP at very low actin concentrations. Adenosine Diphosphate 0-3 myosin VIIB Mus musculus 50-61 16186105-6 2005 ADP and actin binding is uncoupled, which enables myosin VIIb to remain strongly bound to actin and ADP at very low actin concentrations. Adenosine Diphosphate 100-103 myosin VIIB Mus musculus 50-61 16262266-1 2005 In response to DNA strand breaks in the genome of higher eukaryotes, poly(ADP-ribose)polymerase 1 (PARP-1) catalyses the covalent attachment of ADP-ribose units from NAD(+) to various nuclear acceptor proteins including PARP-1 itself. Adenosine Diphosphate 74-77 poly(ADP-ribose) polymerase 1 Homo sapiens 99-105 16262266-1 2005 In response to DNA strand breaks in the genome of higher eukaryotes, poly(ADP-ribose)polymerase 1 (PARP-1) catalyses the covalent attachment of ADP-ribose units from NAD(+) to various nuclear acceptor proteins including PARP-1 itself. Adenosine Diphosphate 74-77 poly(ADP-ribose) polymerase 1 Homo sapiens 220-226 16051982-4 2005 Using a methylation-sensitive restriction fingerprinting method, we identified a novel adenine nucleotide (ADP/ATP) translocase gene, Ant4, that was selectively hypomethylated and expressed in undifferentiated mouse ESCs. Adenosine Diphosphate 107-110 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 Mus musculus 134-138 15920726-0 2005 Involvement of beta1 integrin in microglial chemotaxis and proliferation on fibronectin: different regulations by ADP through PKA. Adenosine Diphosphate 114-117 fibronectin 1 Homo sapiens 76-87 15920726-5 2005 In the present study, we report that the ADP-induced chemotaxis of microglia is mediated by P2Y12/13 receptors and is beta1 integrin-dependent in the presence of fibronectin. Adenosine Diphosphate 41-44 fibronectin 1 Homo sapiens 162-173 16230521-6 2005 Adenosine diphosphate (ADP) at 10(-7) M and beta-subunit antibody suppressed the binding of (125)I-CF6 by 81.3+/-9.7% and 32.0+/-2.0%, respectively, whereas the alpha-subunit antibody unaffected it. Adenosine Diphosphate 0-21 ATP synthase peripheral stalk subunit F6 Homo sapiens 99-102 16230521-6 2005 Adenosine diphosphate (ADP) at 10(-7) M and beta-subunit antibody suppressed the binding of (125)I-CF6 by 81.3+/-9.7% and 32.0+/-2.0%, respectively, whereas the alpha-subunit antibody unaffected it. Adenosine Diphosphate 23-26 ATP synthase peripheral stalk subunit F6 Homo sapiens 99-102 16230521-7 2005 The hydrolysis activity of ATP to ADP was increased by 1.6-fold by CF6 at 10(-7) M, and efrapeptin at 10(-5) M, an inhibitor of ATP synthase, blocked it. Adenosine Diphosphate 34-37 ATP synthase peripheral stalk subunit F6 Homo sapiens 67-70 15955565-3 2005 The P2Y1 receptor is responsible for ADP-induced shape change and weak and transient aggregation, while the P2Y12 receptor is responsible for the completion and amplification of the response to ADP and to all platelet agonists, including thromboxane A2 (TXA2), thrombin, and collagen. Adenosine Diphosphate 194-197 coagulation factor II Mus musculus 261-269 16115861-2 2005 Our previous data on PARP inhibitors in an inflammatory model suggested that PARP-catalyzed ADP-ribosylations may affect signaling pathways, which can play a significant role in cell survival. Adenosine Diphosphate 92-95 poly(ADP-ribose) polymerase 1 Homo sapiens 21-25 16115861-2 2005 Our previous data on PARP inhibitors in an inflammatory model suggested that PARP-catalyzed ADP-ribosylations may affect signaling pathways, which can play a significant role in cell survival. Adenosine Diphosphate 92-95 poly(ADP-ribose) polymerase 1 Homo sapiens 77-81 16194206-2 2005 Here, we investigated the role of adenosine diphosphate (ADP), a major co-activator of platelets, on the activation of Rac. Adenosine Diphosphate 34-55 AKT serine/threonine kinase 1 Homo sapiens 119-122 16194206-2 2005 Here, we investigated the role of adenosine diphosphate (ADP), a major co-activator of platelets, on the activation of Rac. Adenosine Diphosphate 57-60 AKT serine/threonine kinase 1 Homo sapiens 119-122 16194206-3 2005 ADP rapidly activated Rac in a dose-dependent manner and independently of GPIIb/IIIa and phosphoinositide 3-kinase. Adenosine Diphosphate 0-3 AKT serine/threonine kinase 1 Homo sapiens 22-25 16194206-4 2005 ADP alone, used as a primary agonist, activated Rac and its effector PAK via its P2Y1 receptor, through a G(q)-dependent pathway and independently of P2Y12. Adenosine Diphosphate 0-3 AKT serine/threonine kinase 1 Homo sapiens 48-51 16194206-6 2005 Conversely, secreted ADP strongly potentiated Rac activation induced by FcgammaRIIa clustering or TRAP via its P2Y12 receptor, the target of antithrombotic thienopyridines. Adenosine Diphosphate 21-24 AKT serine/threonine kinase 1 Homo sapiens 46-49 16215822-3 2005 The KGD-proinsulin chimera protein inhibits human platelet aggregation, induced by ADP, with an IC50 value (molar concentration causing 50% inhibition of platelet aggregation) of 830 nM: and demonstrates also specific affinity to glycoprotein IIb/IIIa receptor. Adenosine Diphosphate 83-86 insulin Homo sapiens 8-18 15840736-12 2005 Our data further suggest that patients with PlA2 allele homozygosity might benefit from antiplatelet therapy based on adenosine diphosphate antagonists throughout secondary treatment for prevention of ACS. Adenosine Diphosphate 118-139 phospholipase A2 group IB Homo sapiens 44-48 16099990-2 2005 The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). Adenosine Diphosphate 17-38 GNAS complex locus Homo sapiens 89-96 16099990-2 2005 The key event is adenosine diphosphate (ADP)-ribosylation of the human signaling protein GSalpha, catalyzed by the cholera toxin A1 subunit (CTA1). Adenosine Diphosphate 40-43 GNAS complex locus Homo sapiens 89-96 16282990-0 2005 Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin. Adenosine Diphosphate 25-28 arginine vasopressin Homo sapiens 63-74 16282990-0 2005 Correction of changes in ADP-induced platelet aggregation with vasopressin analogue desglycinamide-arginine-vasopressin. Adenosine Diphosphate 25-28 arginine vasopressin Homo sapiens 108-119 15727562-5 2005 Furthermore, there was an increased cleavage of the proapoptotic Bcl-2 family member Bid and an increased release of cytochrome c from mitochondria, in cells treated with TNF in the presence of MitoVit E. We considered several mechanisms by which MitoVit E might accelerate TNF-induced apoptosis including mitochondrial integrity (ATP/ADP levels and permeability transition), alterations in calcium homoeostasis and transcription factor activation. Adenosine Diphosphate 335-338 cytochrome c, somatic Homo sapiens 117-129 15727562-5 2005 Furthermore, there was an increased cleavage of the proapoptotic Bcl-2 family member Bid and an increased release of cytochrome c from mitochondria, in cells treated with TNF in the presence of MitoVit E. We considered several mechanisms by which MitoVit E might accelerate TNF-induced apoptosis including mitochondrial integrity (ATP/ADP levels and permeability transition), alterations in calcium homoeostasis and transcription factor activation. Adenosine Diphosphate 335-338 tumor necrosis factor Homo sapiens 171-174 15863506-1 2005 Binding of thrombopoietin (TPO) to the cMpl receptor on human platelets potentiates aggregation induced by a number of agonists, including ADP. Adenosine Diphosphate 139-142 thrombopoietin Homo sapiens 11-25 15863506-1 2005 Binding of thrombopoietin (TPO) to the cMpl receptor on human platelets potentiates aggregation induced by a number of agonists, including ADP. Adenosine Diphosphate 139-142 thrombopoietin Homo sapiens 27-30 15863506-2 2005 In this work, we found that TPO was able to restore ADP-induced platelet aggregation upon blockade of the G(q)-coupled P2Y1 purinergic receptor but not upon inhibition of the G(i)-coupled P2Y12 receptor. Adenosine Diphosphate 52-55 thrombopoietin Homo sapiens 28-31 15863506-6 2005 However, ADP-induced activation of integrin alpha(IIb)beta(3) was blocked by antagonists of the G(q)-coupled P2Y1 receptor but was completely restored by the simultaneous co-stimulation of cMpl receptor by TPO. Adenosine Diphosphate 9-12 thrombopoietin Homo sapiens 206-209 15943813-5 2005 To determine the functional form of Rio2, we crystallized it after incubation with ATP or ADP and Mn2+. Adenosine Diphosphate 90-93 protein kinase RIO2 Saccharomyces cerevisiae S288C 36-40 15943813-8 2005 Comparison of the Rio2-ATP-Mn complex with the Rio2 structure with no added nucleotides and with the ADP complex indicates that a flexible portion of the Rio2 molecule becomes ordered through direct interaction between His126 and the gamma-phosphate oxygen of ATP. Adenosine Diphosphate 101-104 protein kinase RIO2 Saccharomyces cerevisiae S288C 18-22 15968399-6 2005 Furthermore, ADP enhanced in a P2Y(12)-dependent manner the Ca(2+) response induced by thrombin, which was either added externally or generated in-situ. Adenosine Diphosphate 13-16 coagulation factor II, thrombin Homo sapiens 87-95 15755910-5 2005 We have demonstrated that occupancy of NBD2 by ATP or ADP markedly decreased substrate binding by MRP1. Adenosine Diphosphate 54-57 ATP binding cassette subfamily B member 1 Homo sapiens 98-102 15755910-6 2005 We have further explored the relationship between nucleotide and substrate binding by examining the effects of various ATP analogs and ADP trapping, as well as mutations in conserved functional elements in the NBDs, on the ability of MRP1 to bind the photoactivatable, high-affinity substrate cysteinyl leukotriene C(4) (LTC(4))(.) Adenosine Diphosphate 135-138 ATP binding cassette subfamily B member 1 Homo sapiens 234-238 15731382-1 2005 Adenylate kinase (AdK) and apyrase were employed as helper enzymes to remove ADP in infrared spectroscopic experiments that study the sarcoplasmic reticulum Ca(2+)-ATPase. Adenosine Diphosphate 77-80 adenosine kinase Homo sapiens 18-21 15731382-3 2005 AdK transforms ADP to ATP and AMP, whereas apyrase consumes ATP and ADP to generate AMP and inorganic phosphate. Adenosine Diphosphate 15-18 adenosine kinase Homo sapiens 0-3 15855340-10 2005 In vitro studies in human endothelial and Schwann cells showed early accumulation of poly(ADP-ribosyl)ated proteins (Western blot analysis) in response to high glucose, thus suggesting the importance of PARP activation in human PDN. Adenosine Diphosphate 90-93 poly(ADP-ribose) polymerase 1 Homo sapiens 203-207 15808850-8 2005 As in the case of GroEL, the loading of the second ring is weakened by ADP, implying that asymmetric ATP/ADP complexes are favoured over symmetric ones. Adenosine Diphosphate 71-74 GroEL Escherichia coli 18-23 15808850-8 2005 As in the case of GroEL, the loading of the second ring is weakened by ADP, implying that asymmetric ATP/ADP complexes are favoured over symmetric ones. Adenosine Diphosphate 105-108 GroEL Escherichia coli 18-23 15657938-7 2005 The effects of ATP and ADP on cell migration and proliferation were prevented by the P2Y(1) antagonist MRS2179. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Rattus norvegicus 85-91 15657938-9 2005 These data indicate that ATP and ADP may regulate oligodendrocyte progenitor functions by a mechanism that involves mainly activation of P2Y(1) receptors. Adenosine Diphosphate 33-36 purinergic receptor P2Y1 Rattus norvegicus 137-140 15829969-0 2005 Structure of the apoptotic protease-activating factor 1 bound to ADP. Adenosine Diphosphate 65-68 apoptotic peptidase activating factor 1 Homo sapiens 17-55 15829969-6 2005 Here we report the 2.2-A crystal structure of an ADP-bound, WD40-deleted Apaf-1, which reveals the molecular mechanism by which Apaf-1 exists in an inactive state before ATP binding. Adenosine Diphosphate 49-52 apoptotic peptidase activating factor 1 Homo sapiens 73-79 15829969-6 2005 Here we report the 2.2-A crystal structure of an ADP-bound, WD40-deleted Apaf-1, which reveals the molecular mechanism by which Apaf-1 exists in an inactive state before ATP binding. Adenosine Diphosphate 49-52 apoptotic peptidase activating factor 1 Homo sapiens 128-134 15829969-8 2005 The deeply buried ADP molecule serves as an organizing centre to strengthen interactions between these four adjoining domains, thus locking Apaf-1 in an inactive conformation. Adenosine Diphosphate 18-21 apoptotic peptidase activating factor 1 Homo sapiens 140-146 15752705-2 2005 Because glucokinase has been resistant to crystallization, computer generated homology models were developed based on the X-ray crystal structure of the COOH-terminal domain of human brain hexokinase 1 bound to glucose and ADP or glucose and glucose-6-phosphate. Adenosine Diphosphate 223-226 hexokinase 1 Homo sapiens 189-201 15868400-4 2005 On the "dark side" of poly(ADP-ribosyl)ation, PARP-1 activation has been shown to contribute to tissue injury in shock, diabetes, myocardial or cerebral ischemia reperfusion and various forms of inflammation, as proven by pharmacological studies as well as experiments utilizing PARP-1 knockout animals. Adenosine Diphosphate 27-30 poly(ADP-ribose) polymerase 1 Homo sapiens 46-52 15719372-6 2005 The ATP analogue adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S) and adenosine 5"-diphosphate (ADP) also inhibited TNF-alpha release, but only ADP showed a stimulatory effect on IL-10. Adenosine Diphosphate 71-95 tumor necrosis factor Homo sapiens 117-126 15821821-11 2005 vWF and diastolic blood pressure were significant predictors for adenosine diphosphate-induced platelet aggregability. Adenosine Diphosphate 65-86 von Willebrand factor Homo sapiens 0-3 15767296-1 2005 Previously, we demonstrated that ADP inhibits cystic fibrosis transmembrane conductance regulator (CFTR) opening by competing with ATP for a binding site presumably in the COOH-terminal nucleotide binding domain (NBD2). Adenosine Diphosphate 33-36 CF transmembrane conductance regulator Homo sapiens 46-97 15767296-1 2005 Previously, we demonstrated that ADP inhibits cystic fibrosis transmembrane conductance regulator (CFTR) opening by competing with ATP for a binding site presumably in the COOH-terminal nucleotide binding domain (NBD2). Adenosine Diphosphate 33-36 CF transmembrane conductance regulator Homo sapiens 99-103 15767296-4 2005 Single-channel kinetic analysis of DeltaR/D1370N-CFTR shows unequivocally that the open time of this mutant channel is decreased by ADP. Adenosine Diphosphate 132-135 CF transmembrane conductance regulator Homo sapiens 49-53 15852218-5 2005 This receptor, the molecular target of the antithrombotic drug clopidogrel, is responsible for most of the potentiating effects of ADP when platelets are stimulated by agents such as thrombin, collagen, or immune complexes. Adenosine Diphosphate 131-134 coagulation factor II, thrombin Homo sapiens 183-191 15674325-6 2005 Molecular modeling and biochemical analysis define a PARP domain that is capable of ADP-ribosylating PARP-10 itself and core histones, but neither Myc nor Max. Adenosine Diphosphate 84-87 poly(ADP-ribose) polymerase 1 Homo sapiens 53-57 15674325-6 2005 Molecular modeling and biochemical analysis define a PARP domain that is capable of ADP-ribosylating PARP-10 itself and core histones, but neither Myc nor Max. Adenosine Diphosphate 84-87 poly(ADP-ribose) polymerase family member 10 Homo sapiens 101-108 15749861-2 2005 Upon exposure of T cells to NAD, the substrate for ADP-ribosylation, ART2 catalyzes ADP-ribosylation of the P2X7 purinoceptor and other functionally important cell surface proteins. Adenosine Diphosphate 51-54 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 108-125 15749861-2 2005 Upon exposure of T cells to NAD, the substrate for ADP-ribosylation, ART2 catalyzes ADP-ribosylation of the P2X7 purinoceptor and other functionally important cell surface proteins. Adenosine Diphosphate 84-87 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 108-125 15735337-3 2005 The present contribution reports the rapid crystal structure determination of human UCK2 complexed with a magnesium ion and the reaction products adenosine 5"-diphosphate (ADP) and CMP. Adenosine Diphosphate 146-170 uridine-cytidine kinase 2 Homo sapiens 84-88 15735337-3 2005 The present contribution reports the rapid crystal structure determination of human UCK2 complexed with a magnesium ion and the reaction products adenosine 5"-diphosphate (ADP) and CMP. Adenosine Diphosphate 172-175 uridine-cytidine kinase 2 Homo sapiens 84-88 15719372-6 2005 The ATP analogue adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S) and adenosine 5"-diphosphate (ADP) also inhibited TNF-alpha release, but only ADP showed a stimulatory effect on IL-10. Adenosine Diphosphate 97-100 tumor necrosis factor Homo sapiens 117-126 15485840-2 2004 Specifically, tin-9.1 and tin-10 RNA interference (RNAi) treatment of nematodes impairs import of the ADP/ATP carrier into isolated mitochondria. Adenosine Diphosphate 102-105 Mitochondrial import inner membrane translocase subunit Tim9 Caenorhabditis elegans 14-21 15709756-6 2005 Addition of AlCl(3) and NaF to the reduced double mutant after incubation with stoichiometric MgADP or 200 microM MgADP irreversibly inactivated the steady state ATPase activity with rate constants of 1.5 x10(-2) and 4.1 x 10(-2) min(-1), respectively. Adenosine Diphosphate 94-99 C-X-C motif chemokine ligand 8 Homo sapiens 24-27 15709756-6 2005 Addition of AlCl(3) and NaF to the reduced double mutant after incubation with stoichiometric MgADP or 200 microM MgADP irreversibly inactivated the steady state ATPase activity with rate constants of 1.5 x10(-2) and 4.1 x 10(-2) min(-1), respectively. Adenosine Diphosphate 114-119 C-X-C motif chemokine ligand 8 Homo sapiens 24-27 15728851-3 2005 Activation of P2Y purinoceptors by two selective agonists, ADP and 2-methylthio-ADP (2MeSADP), elicited two distinct forms of synaptic plasticity of GABAergic transmission in the cerebellar cortex. Adenosine Diphosphate 59-62 purinergic receptor P2Y1 Rattus norvegicus 14-17 15557277-4 2005 The site of phosphorylation, identified by mass spectrometry, is tyrosine 304 of COX catalytic subunit I. Subunit I phosphorylation leads to a decrease of V(max) and an increase of K(m) for cytochrome c and shifts the reaction kinetics from hyperbolic to sigmoidal such that COX is fully or strongly inhibited up to 10 mum cytochrome c substrate concentrations, even in the presence of allosteric activator ADP. Adenosine Diphosphate 407-410 cytochrome c, somatic Homo sapiens 190-202 15557277-4 2005 The site of phosphorylation, identified by mass spectrometry, is tyrosine 304 of COX catalytic subunit I. Subunit I phosphorylation leads to a decrease of V(max) and an increase of K(m) for cytochrome c and shifts the reaction kinetics from hyperbolic to sigmoidal such that COX is fully or strongly inhibited up to 10 mum cytochrome c substrate concentrations, even in the presence of allosteric activator ADP. Adenosine Diphosphate 407-410 cytochrome c, somatic Homo sapiens 323-335 15557326-9 2005 In membranes expressing the ABCG2-K86M mutant, ATP, ADP, and AMP-PNP decreased, whereas Ko143 increased 5D3 binding. Adenosine Diphosphate 52-55 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 28-33 15684079-0 2005 ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity. Adenosine Diphosphate 0-3 CF transmembrane conductance regulator Homo sapiens 45-96 15684079-1 2005 ADP interacts with the nucleotide-binding domains (NBDs) of the cystic fibrosis transmembrane conductance regulator (CFTR) to inhibit its Cl- channel activity. Adenosine Diphosphate 0-3 CF transmembrane conductance regulator Homo sapiens 64-115 15684079-1 2005 ADP interacts with the nucleotide-binding domains (NBDs) of the cystic fibrosis transmembrane conductance regulator (CFTR) to inhibit its Cl- channel activity. Adenosine Diphosphate 0-3 CF transmembrane conductance regulator Homo sapiens 117-121 15684079-2 2005 Because CFTR NBD2 has reversible adenylate kinase activity (ATP + AMP<==> ADP + ADP) that gates the channel, we asked whether ADP might inhibit current through this enzymatic activity. Adenosine Diphosphate 80-83 CF transmembrane conductance regulator Homo sapiens 8-12 15684079-4 2005 Consistent with this hypothesis, CFTR current inhibition showed positive cooperativity for ADP. Adenosine Diphosphate 91-94 CF transmembrane conductance regulator Homo sapiens 33-37 15563471-0 2005 Interdependent regulation of insulin receptor kinase activity by ADP and hydrogen peroxide. Adenosine Diphosphate 65-68 insulin Homo sapiens 29-36 15548765-6 2005 PARP-1 inhibition blocked ADP-ribose polymer formation, preserved mitochondrial membrane integrity, and counteracted the reduction of NF-kappaB activity, thus preventing the appearance of necrosis. Adenosine Diphosphate 26-29 poly(ADP-ribose) polymerase 1 Homo sapiens 0-6 15684029-4 2005 Our results indicate that BiP must assume the ADP-bound conformation to seal the translocon, and that the reopening of the pore requires an ATP binding-induced conformational change. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 5 Homo sapiens 26-29 15579373-5 2005 Besides, we showed IL-6sR release during platelet activation induced by thrombin and a complex of ADP and epinephrine. Adenosine Diphosphate 98-101 interleukin 6 receptor Homo sapiens 19-25 15514209-5 2005 Associations between selected polymorphisms and the platelet response to ADP (0.1, 1.0, and 10 micromol/L), assessed by whole blood flow cytometric measurement of fibrinogen binding to activated glycoprotein IIb-IIIa, were then determined in 200 subjects. Adenosine Diphosphate 73-76 fibrinogen beta chain Homo sapiens 163-173 15320873-0 2005 A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Adenosine Diphosphate 47-50 protein transporter TIM23 Saccharomyces cerevisiae S288C 123-128 15320873-1 2005 The yeast ADP/ATP carrier (AAC) is a mitochondrial protein that is targeted to the inner membrane via the TIM10 and TIM22 translocase complexes. Adenosine Diphosphate 10-13 protein transporter TIM10 Saccharomyces cerevisiae S288C 106-111 15494463-8 2005 However, the GHD-2 group has increased thrombin-evoked [Ca(2+)](i) (297.0 +/- 15.7 Deltanmol/liter; P < 0.01), collagen, and ADP-induced platelet aggregation (33.3 +/- 4.3 and 12.5 +/- 2.1 Omega, respectively; P < 0.05) vs. the control-2 group (Delta[Ca(2+)](i): 102.1 +/- 13.6 Deltanmol/liter; aggregation: 19.6 +/- 2.9 and 6.2 +/- 0.8 Omega). Adenosine Diphosphate 128-131 coagulation factor II, thrombin Homo sapiens 39-47 15935833-5 2005 ADP-induced platelet fibrinogen binding was, however, higher at 0.125 mM, but lower at 5 and 10 mM [Ca(2+)], as compared to 1.25 mM [Ca(2+)]. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 21-31 15613030-6 2004 When secreted ADP was neutralized, activation of Rap2B induced by thrombin, but not by convulxin, was significantly reduced. Adenosine Diphosphate 14-17 coagulation factor II, thrombin Homo sapiens 66-74 15585881-5 2004 Low doses of ADP induced strong phosphorylation of ERK and p38 MAPKs; higher doses stimulated eicosanoid production and exocytosis. Adenosine Diphosphate 13-16 mitogen-activated protein kinase 14 Homo sapiens 59-62 15585881-7 2004 Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4). Adenosine Diphosphate 19-22 tumor necrosis factor Homo sapiens 59-68 15585881-7 2004 Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4). Adenosine Diphosphate 19-22 toll like receptor 2 Homo sapiens 88-92 15585881-7 2004 Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4). Adenosine Diphosphate 19-22 tumor necrosis factor Homo sapiens 146-155 15585881-7 2004 Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4). Adenosine Diphosphate 19-22 C-X-C motif chemokine ligand 8 Homo sapiens 157-161 15618627-1 2004 The 70 kDa heat shock proteins (HSP70) are a family of molecular chaperones that bind transiently to unfolded proteins in an ATP/ADP dependent manner. Adenosine Diphosphate 129-132 heat shock protein family A (Hsp70) member 9 Homo sapiens 32-37 15618627-6 2004 ATP, adenosine 5"-O-(3-thiotriphosphate) (ATP-gamma-S), and ADP not only protected the endonucleolytic activity against heat inactivation in the presence of Ca(2+) ions, but also reduced the labeling of the HSP70-subunit by [gamma-(32)P]ATP in Endo.SceI. Adenosine Diphosphate 60-63 heat shock protein family A (Hsp70) member 9 Homo sapiens 207-212 15618627-7 2004 These findings suggest that the HSP70-subunit shields Endo.SceI from heat inactivation through ATP/ADP binding. Adenosine Diphosphate 99-102 heat shock protein family A (Hsp70) member 9 Homo sapiens 32-37 15284110-6 2004 Our results demonstrate that, under elevated shear stress conditions, ADP signaling through P2Y(1) may contribute to the initial stages of platelet adhesion and activation mediated by immobilized VWF, and through P2Y(12) to sustained thrombus formation. Adenosine Diphosphate 70-73 von Willebrand factor Homo sapiens 196-199 15578915-7 2004 The release of cytochrome c from mitochondria to the cytosol during apoptosis is mediated by the mitochondrial permeability transition pore, which is a protein complex formed by the voltage-dependent anion channel, members of the pro- and anti- apoptotic Bax-Bcl-2 protein family, cyclophilin D, and adenine nucleotide (ADP/ATP) translocators. Adenosine Diphosphate 320-323 cytochrome c, somatic Homo sapiens 15-27 15578915-7 2004 The release of cytochrome c from mitochondria to the cytosol during apoptosis is mediated by the mitochondrial permeability transition pore, which is a protein complex formed by the voltage-dependent anion channel, members of the pro- and anti- apoptotic Bax-Bcl-2 protein family, cyclophilin D, and adenine nucleotide (ADP/ATP) translocators. Adenosine Diphosphate 320-323 BCL2 associated X, apoptosis regulator Homo sapiens 255-258 15578915-7 2004 The release of cytochrome c from mitochondria to the cytosol during apoptosis is mediated by the mitochondrial permeability transition pore, which is a protein complex formed by the voltage-dependent anion channel, members of the pro- and anti- apoptotic Bax-Bcl-2 protein family, cyclophilin D, and adenine nucleotide (ADP/ATP) translocators. Adenosine Diphosphate 320-323 BCL2 apoptosis regulator Homo sapiens 259-264 15578915-7 2004 The release of cytochrome c from mitochondria to the cytosol during apoptosis is mediated by the mitochondrial permeability transition pore, which is a protein complex formed by the voltage-dependent anion channel, members of the pro- and anti- apoptotic Bax-Bcl-2 protein family, cyclophilin D, and adenine nucleotide (ADP/ATP) translocators. Adenosine Diphosphate 320-323 peptidylprolyl isomerase F Homo sapiens 281-294 15489198-4 2004 The protective effect of Bcl-x(L) was more prominent in respiratory-competent cells that contained defects in mitochondrial ADP/ATP translocation, suggesting a model for Bcl-x(L) regulation of chronological ageing at the mitochondria. Adenosine Diphosphate 124-127 BCL2 like 1 Homo sapiens 25-33 15489198-4 2004 The protective effect of Bcl-x(L) was more prominent in respiratory-competent cells that contained defects in mitochondrial ADP/ATP translocation, suggesting a model for Bcl-x(L) regulation of chronological ageing at the mitochondria. Adenosine Diphosphate 124-127 BCL2 like 1 Homo sapiens 170-178 15450800-1 2004 The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units. Adenosine Diphosphate 16-19 poly(ADP-ribose) glycohydrolase Homo sapiens 44-48 15450800-1 2004 The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units. Adenosine Diphosphate 98-101 poly(ADP-ribose) glycohydrolase Homo sapiens 11-42 15450800-1 2004 The enzyme poly(ADP-ribose) glycohydrolase (PARG) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units. Adenosine Diphosphate 98-101 poly(ADP-ribose) glycohydrolase Homo sapiens 44-48 15450800-6 2004 This article describes a method whereby the ADP-ribose product of the PARG-catalyzed reaction is converted into a fluorescent dye. Adenosine Diphosphate 44-47 poly(ADP-ribose) glycohydrolase Homo sapiens 70-74 15605108-3 2004 Platelet stimuli like ADP, thrombin or thromboxane A(2) activate receptors that are coupled to heterotrimeric G proteins to regulate intracellular signaling pathways. Adenosine Diphosphate 22-25 coagulation factor II, thrombin Homo sapiens 27-35 15451781-7 2004 Selective inhibition of Cox-2 (NS-398, 0.5 mg/kg) increased platelet adhesion to the vessel wall in vivo (11.9+/-3.9 platelets/mm2; controls, 1.4+/-1.4 platelets/mm2, P<0.05) and platelet adhesion after ADP stimulation in vitro. Adenosine Diphosphate 206-209 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-29 15363460-7 2004 Rather unexpectedly, however, swinging of the lobes situated Tyr-416 in a suitable position for intramolecular autophosphorylation, and further simulation of Tyr-416-phosphorylated Src in the presence of ADP did then result in a conformational change that placed the activation loop in a position similar to that found in the active open conformation of Lck. Adenosine Diphosphate 204-207 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 181-184 15240747-4 2004 ADP, 2-methylthio-ADP, and ADPbetaS had no effect on cAMP, increased [Ca2+]i, and stimulated the phosphorylation of ERK1. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 3 Homo sapiens 116-120 15457162-13 2004 In the aprotinin group, coronary microvessel relaxation improved most in response to the endothelium-dependent agonist adenosine diphosphate (44.7% +/- 3.2% vs 19.7% +/- 1.7%, aprotinin vs control; P <.01). Adenosine Diphosphate 119-140 pancreatic trypsin inhibitor-like Sus scrofa 7-16 15457162-13 2004 In the aprotinin group, coronary microvessel relaxation improved most in response to the endothelium-dependent agonist adenosine diphosphate (44.7% +/- 3.2% vs 19.7% +/- 1.7%, aprotinin vs control; P <.01). Adenosine Diphosphate 119-140 pancreatic trypsin inhibitor-like Sus scrofa 176-185 15350215-2 2004 The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. Adenosine Diphosphate 177-198 inositol-trisphosphate 3-kinase B Homo sapiens 53-90 15623154-3 2004 ATP, ADP and anticancer drugs can all reduce the rate of reaction of MRP1 with MIANS. Adenosine Diphosphate 5-8 ATP binding cassette subfamily C member 1 Homo sapiens 69-73 15350215-2 2004 The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. Adenosine Diphosphate 177-198 inositol-trisphosphate 3-kinase B Homo sapiens 92-96 15313620-2 2004 Here, we have modeled the anisotropic displacements of GroEL domains from various crystallized states, unliganded GroEL, ATPgammaS-bound, ADP-AlFx/GroES-bound, and ADP/GroES bound, using translation-libration-screw (TLS) analysis. Adenosine Diphosphate 138-141 GroEL Escherichia coli 55-60 15313620-2 2004 Here, we have modeled the anisotropic displacements of GroEL domains from various crystallized states, unliganded GroEL, ATPgammaS-bound, ADP-AlFx/GroES-bound, and ADP/GroES bound, using translation-libration-screw (TLS) analysis. Adenosine Diphosphate 164-167 GroEL Escherichia coli 55-60 15665914-5 2004 ADP initiated platelet aggregation, which was in direct proportion to the degree of fibrinogen oxidation. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 84-94 15935833-12 2005 High [Ca(2+)] enhances spontaneous platelet fibrinogen binding, but reduces ADP-induced platelet fibrinogen binding, while low [Ca(2+)] enhances ADP-induced platelet fibrinogen binding. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 97-107 15935833-12 2005 High [Ca(2+)] enhances spontaneous platelet fibrinogen binding, but reduces ADP-induced platelet fibrinogen binding, while low [Ca(2+)] enhances ADP-induced platelet fibrinogen binding. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 97-107 15487851-6 2004 Clopidogrel has additional effects on the ADP-induced expression of adhesion molecules (P-selectin, GPIIb/IIIa) and inflammatory mediators (CD40L). Adenosine Diphosphate 42-45 CD40 ligand Homo sapiens 140-145 15265806-0 2004 Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation. Adenosine Diphosphate 74-77 coagulation factor II, thrombin Homo sapiens 62-70 15194626-7 2004 RESULTS: Addition of tirofiban (70-280 ng ml(-1)) progressively delayed onset of thrombin generation triggered by adenosine diphosphate (ADP). Adenosine Diphosphate 114-135 coagulation factor II, thrombin Homo sapiens 81-89 15194626-7 2004 RESULTS: Addition of tirofiban (70-280 ng ml(-1)) progressively delayed onset of thrombin generation triggered by adenosine diphosphate (ADP). Adenosine Diphosphate 137-140 coagulation factor II, thrombin Homo sapiens 81-89 15265806-1 2004 The objective of this study was to investigate if there is a synergistic effect of a combination of P2Y(12) and P2Y(1) inhibition and P2Y(12) and thrombin inhibition, on ADP- and thrombin-induced platelet activation, respectively. Adenosine Diphosphate 170-173 coagulation factor II, thrombin Homo sapiens 146-154 15243297-4 2004 When rings were tonically contracted by U46619 a thromboxane A2 analogue, ATP, ADP, ATP gamma S, 2-(methylthio)adenosine 5"-diphosphate, and UTP caused endothelium-dependent but not independent relaxations.I conclude that ATP acts on P2Y2 and P2Y1 receptors on the endothelial cells to cause endothelium-dependent relaxation. Adenosine Diphosphate 79-82 purinergic receptor P2Y, G-protein coupled 2 Mus musculus 234-238 15236970-3 2004 Here we report the 2.5A resolution crystal structure of the motor domain and linker region of human CENP-E with MgADP bound in the active site. Adenosine Diphosphate 112-117 centromere protein E Homo sapiens 100-106 15296740-3 2004 We determined the crystal structure of the native GroEL-GroES-ADP homolog from Thermus thermophilus, with substrate proteins in the cis-cavity, at 2.8 A resolution. Adenosine Diphosphate 62-65 GroEL Escherichia coli 50-55 15213852-0 2004 ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 78-86 15183123-5 2004 Expression of rP2Y(13) receptor in 1321N1 cells induced the appearance of responses to the typical P2Y(13) receptor agonists ADP and 2MeSADP, as detected by stimulation of [(35)S]GTPgammaS binding. Adenosine Diphosphate 125-128 purinergic receptor P2Y1 Rattus norvegicus 15-18 15305227-7 2004 Previously, we detected a significant correlation between prolactin values and ADP-stimulated P-selectin expression on platelets in pregnant women, patients with pituitary tumours, and patients on anti-psychotic therapy. Adenosine Diphosphate 79-82 prolactin Homo sapiens 58-67 15305227-11 2004 Moreover, our data suggest that the stronger effect of prolactin on ADP-stimulated platelet aggregation, compared to leptin, depends on higher stimulation of CD62p expression by prolactin. Adenosine Diphosphate 68-71 prolactin Homo sapiens 55-64 15305227-11 2004 Moreover, our data suggest that the stronger effect of prolactin on ADP-stimulated platelet aggregation, compared to leptin, depends on higher stimulation of CD62p expression by prolactin. Adenosine Diphosphate 68-71 prolactin Homo sapiens 178-187 15213852-14 2004 Our data indicate that both primary signalling through Gq, which evokes ADP secretion, as well as subsequent coupling via Gi by the P2Y12 receptor are required for ERK2 activation. Adenosine Diphosphate 72-75 mitogen-activated protein kinase 1 Homo sapiens 164-168 15213852-0 2004 ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets. Adenosine Diphosphate 0-3 mitogen-activated protein kinase 1 Homo sapiens 95-99 15078882-7 2004 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase, activation of Rap1B induced by stimulation of either PAR-1 or PAR-4 was totally inhibited. Adenosine Diphosphate 23-26 coagulation factor II thrombin receptor Homo sapiens 142-147 15078882-8 2004 By contrast, thrombin-induced activation of Rap1B was only minimally affected by neutralization of secreted ADP. Adenosine Diphosphate 108-111 coagulation factor II, thrombin Homo sapiens 13-21 15078882-9 2004 Concomitant stimulation of both PAR-1 and PAR-4 in the presence of ADP scavengers still resulted in a strongly reduced activation of Rap1B. Adenosine Diphosphate 67-70 coagulation factor II thrombin receptor Homo sapiens 32-37 15078882-11 2004 Activation of Rap1B induced by thrombin was not affected by preincubation of platelets with the anti-GPIbalpha monoclonal antibody AK2 in the absence of ADP scavengers or a P2Y12 antagonist but was totally abolished when secreted ADP was neutralized or after blockade of the P2Y12 receptor. Adenosine Diphosphate 230-233 coagulation factor II, thrombin Homo sapiens 31-39 14759224-6 2004 In contrast, Site II could be identified as part of the substrate-modulated catalytic cycle, probably containing an MRP1.MgADP.Vi transition-state-like complex. Adenosine Diphosphate 121-126 ATP binding cassette subfamily C member 1 Homo sapiens 116-120 15386949-6 2004 CONCLUSION: The findings in the present study suggest that ADP can cause oxidative stress and free radical damage, and inhibit markedly erythrocyte acetylcholinesterase activity in ADPPs. Adenosine Diphosphate 59-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 15189857-4 2004 The model is illustrated by the quantification of nanomolar levels of ADP (and/or ATP) in a continuous assay involving the enzymes L-lactate dehydrogenase and L-lactate oxidase to cycle the pyruvate accumulated in a first enzymatic cycle constituted by the enzymes pyruvate kinase and hexokinase. Adenosine Diphosphate 70-73 hexokinase 1 Homo sapiens 285-295 15122917-6 2004 Both intact cells and crude cell lysates from COS-7 cells expressing NTPDase8 hydrolyzed P2 receptor agonists, namely, ATP, ADP, UTP, and UDP, but did not hydrolyze AMP. Adenosine Diphosphate 124-127 ectonucleoside triphosphate diphosphohydrolase 8 Mus musculus 69-77 14766012-10 2004 A homology model of the first repeat of UCP1, built on the basis of X-ray-solved close parent, the ADP/ATP carrier, strengthened the CD experimental results. Adenosine Diphosphate 99-102 uncoupling protein 1 Rattus norvegicus 40-44 15099288-9 2004 We also investigated the ability of ADP to potentiate agonist-induced thrombin generation. Adenosine Diphosphate 36-39 coagulation factor II, thrombin Homo sapiens 70-78 14742747-7 2004 The addition of ADP, 2-MeS-ATP, ATP, or UTP were also found to activate the ERK1/2 signaling pathway. Adenosine Diphosphate 16-19 mitogen-activated protein kinase 3 Homo sapiens 76-82 15065809-2 2004 The enzymatic conversion of nucleotide adenosine triphosphate (ATP) to adenosine diphosphate (ADP) by hexokinase (HK) was monitored in the bioreactor interfaced by a laboratory-built microsampler to a capillary electrophoresis unit. Adenosine Diphosphate 71-92 hexokinase 1 Homo sapiens 102-112 15100056-6 2004 Here we propose a new mechanism for the increased DeltaPsi(m) based on experiments on the allosteric ATP-inhibition of cytochrome c oxidase at high matrix ATP/ADP ratios, which was concluded to maintain low levels of DeltaPsi(m) in vivo under relaxed conditions. Adenosine Diphosphate 159-162 cytochrome c, somatic Homo sapiens 119-131 15065809-2 2004 The enzymatic conversion of nucleotide adenosine triphosphate (ATP) to adenosine diphosphate (ADP) by hexokinase (HK) was monitored in the bioreactor interfaced by a laboratory-built microsampler to a capillary electrophoresis unit. Adenosine Diphosphate 71-92 hexokinase 1 Homo sapiens 114-116 15065809-2 2004 The enzymatic conversion of nucleotide adenosine triphosphate (ATP) to adenosine diphosphate (ADP) by hexokinase (HK) was monitored in the bioreactor interfaced by a laboratory-built microsampler to a capillary electrophoresis unit. Adenosine Diphosphate 94-97 hexokinase 1 Homo sapiens 102-112 15065809-2 2004 The enzymatic conversion of nucleotide adenosine triphosphate (ATP) to adenosine diphosphate (ADP) by hexokinase (HK) was monitored in the bioreactor interfaced by a laboratory-built microsampler to a capillary electrophoresis unit. Adenosine Diphosphate 94-97 hexokinase 1 Homo sapiens 114-116 15019868-9 2004 Clopidogrel pretreatment was associated with lower ADP-activated platelet CD40L expression in baseline and postprocedural samples. Adenosine Diphosphate 51-54 CD40 ligand Homo sapiens 74-79 15232628-0 2004 Mechanism of activation of ADP-induced platelet aggregation under the influence of oxidatively modified fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 104-114 14615385-3 2004 In streptolysin O-permeabilized PMNs, PLD was directly activated by guanosine 5"-[gamma-thio]triphosphate (GTP gamma S) stimulation of adenosine diphosphate (ADP)-ribosylation factor (ARF) and Rho, stimulating release of lactoferrin from specific granules of permeabilized PMNs; PLD activation and degranulation were inhibited by C2-ceramide but not dihydro-C2-ceramide. Adenosine Diphosphate 135-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 14615385-3 2004 In streptolysin O-permeabilized PMNs, PLD was directly activated by guanosine 5"-[gamma-thio]triphosphate (GTP gamma S) stimulation of adenosine diphosphate (ADP)-ribosylation factor (ARF) and Rho, stimulating release of lactoferrin from specific granules of permeabilized PMNs; PLD activation and degranulation were inhibited by C2-ceramide but not dihydro-C2-ceramide. Adenosine Diphosphate 135-156 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 279-282 14615385-3 2004 In streptolysin O-permeabilized PMNs, PLD was directly activated by guanosine 5"-[gamma-thio]triphosphate (GTP gamma S) stimulation of adenosine diphosphate (ADP)-ribosylation factor (ARF) and Rho, stimulating release of lactoferrin from specific granules of permeabilized PMNs; PLD activation and degranulation were inhibited by C2-ceramide but not dihydro-C2-ceramide. Adenosine Diphosphate 158-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 14615385-3 2004 In streptolysin O-permeabilized PMNs, PLD was directly activated by guanosine 5"-[gamma-thio]triphosphate (GTP gamma S) stimulation of adenosine diphosphate (ADP)-ribosylation factor (ARF) and Rho, stimulating release of lactoferrin from specific granules of permeabilized PMNs; PLD activation and degranulation were inhibited by C2-ceramide but not dihydro-C2-ceramide. Adenosine Diphosphate 158-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 279-282 14685157-5 2004 The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Adenosine Diphosphate 23-26 poly(ADP-ribose) glycohydrolase Homo sapiens 38-69 14685157-5 2004 The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Adenosine Diphosphate 23-26 poly(ADP-ribose) glycohydrolase Homo sapiens 71-75 14685157-5 2004 The hydrolysis of poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase (PARG) was also required, since specific PARG inhibitors, which limit the production of ADP-ribose molecules, restored the function of ABC transporters. Adenosine Diphosphate 23-26 poly(ADP-ribose) glycohydrolase Homo sapiens 111-115 14872319-13 2004 The lack of effect of metabolic inhibition by sodium azide shows that in SUR1(-/-) beta cells changes in ATP/ADP no longer link glucose metabolism and Vm. Adenosine Diphosphate 109-112 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus 73-77 14987257-4 2004 PARP-1 attaches most ADP-ribose residues onto itself, leading to downregulation of enzyme activity. Adenosine Diphosphate 21-24 poly(ADP-ribose) polymerase 1 Homo sapiens 0-6 14987257-9 2004 Therefore, PARG is likely to contribute to maintaining the active state of PARP-1 by continuously removing inhibitory ADP-ribose residues from PARP-1. Adenosine Diphosphate 118-121 poly(ADP-ribose) glycohydrolase Homo sapiens 11-15 14987257-9 2004 Therefore, PARG is likely to contribute to maintaining the active state of PARP-1 by continuously removing inhibitory ADP-ribose residues from PARP-1. Adenosine Diphosphate 118-121 poly(ADP-ribose) polymerase 1 Homo sapiens 75-81 15076227-0 2004 Inhibition of ADP-evoked platelet aggregation by selected poly(ADP-ribose) polymerase inhibitors. Adenosine Diphosphate 14-17 poly(ADP-ribose) polymerase 1 Homo sapiens 58-85 15076227-2 2004 Since cardiomyocytes can be protected from ischemia-reoxygenation injury by poly(ADP-ribose) polymerase (PARP) inhibitors mimicking the adenine/ADP part of NAD, their structural resemblance to ADP may also enable the blockade of platelet aggregation via binding to ADP receptors. Adenosine Diphosphate 81-84 poly(ADP-ribose) polymerase 1 Homo sapiens 105-109 15076227-2 2004 Since cardiomyocytes can be protected from ischemia-reoxygenation injury by poly(ADP-ribose) polymerase (PARP) inhibitors mimicking the adenine/ADP part of NAD, their structural resemblance to ADP may also enable the blockade of platelet aggregation via binding to ADP receptors. Adenosine Diphosphate 144-147 poly(ADP-ribose) polymerase 1 Homo sapiens 76-103 15076227-2 2004 Since cardiomyocytes can be protected from ischemia-reoxygenation injury by poly(ADP-ribose) polymerase (PARP) inhibitors mimicking the adenine/ADP part of NAD, their structural resemblance to ADP may also enable the blockade of platelet aggregation via binding to ADP receptors. Adenosine Diphosphate 144-147 poly(ADP-ribose) polymerase 1 Homo sapiens 105-109 15076227-6 2004 All examined PARP inhibitors reduced the ADP-induced platelet aggregation in a dose-dependent manner (significant inhibition at 20 microM for HO-3089 and at 500 microM for the other agents; P < 0.05), even if platelets were sensitized with heparin. Adenosine Diphosphate 41-44 poly(ADP-ribose) polymerase 1 Homo sapiens 13-17 14623889-7 2004 However, ADP caused Akt phosphorylation in Galphaq- and P2Y1-deficient platelets, which was completely blocked by AR-C69931MX. Adenosine Diphosphate 9-12 thymoma viral proto-oncogene 1 Mus musculus 20-23 14623889-9 2004 These data demonstrate that Gi, but not Gq or G12/13, signaling pathways are required for activation of Akt in platelets, and Gi signaling pathways, stimulated by secreted ADP, play an essential role in the activation of Akt in platelets. Adenosine Diphosphate 172-175 thymoma viral proto-oncogene 1 Mus musculus 221-224 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 mitogen-activated protein kinase 3 Homo sapiens 67-75 14645230-1 2004 ATP-sensitive potassium (KATP) channels in neuron and neuroendocrine cells consist of a pore-forming Kir6.2 and regulatory sulfonylurea receptor (SUR1) subunits, which are regulated by ATP and ADP. Adenosine Diphosphate 193-196 ATP binding cassette subfamily C member 8 Rattus norvegicus 146-150 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 mitogen-activated protein kinase 1 Homo sapiens 84-88 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 mitogen-activated protein kinase 3 Homo sapiens 199-203 14602724-4 2004 Here we report that insulin (0.5-200 nmol/liter) interferes with agonist-induced increases in [Ca(2+)](i) (ADP, thrombin), cAMP suppression (thrombin), and aggregation (ADP). Adenosine Diphosphate 107-110 insulin Homo sapiens 20-27 18228447-1 2004 Poly(ADP-ribosyl)ation is a post-translational modification catalyzed mostly by the 116-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme that transfers an ADP-ribose moiety onto a limited number of nuclear proteins, including itself. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 99-128 18228447-1 2004 Poly(ADP-ribosyl)ation is a post-translational modification catalyzed mostly by the 116-kDa enzyme poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme that transfers an ADP-ribose moiety onto a limited number of nuclear proteins, including itself. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 130-136 14749274-7 2004 The molecular mechanism by which the A3243G mutation affects insulin secretion may involve an attenuation of cytosolic ADP/ATP levels leading to a resetting of the glucose sensor in the pancreatic beta-cell, such as in maturity-onset diabetes of the young (MODY)-2 patients with mutations in glucokinase. Adenosine Diphosphate 119-122 insulin Homo sapiens 61-68 14755341-7 2004 Activation of Akt by thrombin was abolished by deletion of Galpha(q) but was relatively unaffected by deletion of Galpha(i2), which abolished Akt activation by ADP. Adenosine Diphosphate 160-163 thymoma viral proto-oncogene 1 Mus musculus 14-17 14755341-7 2004 Activation of Akt by thrombin was abolished by deletion of Galpha(q) but was relatively unaffected by deletion of Galpha(i2), which abolished Akt activation by ADP. Adenosine Diphosphate 160-163 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 114-123 14755341-7 2004 Activation of Akt by thrombin was abolished by deletion of Galpha(q) but was relatively unaffected by deletion of Galpha(i2), which abolished Akt activation by ADP. Adenosine Diphosphate 160-163 thymoma viral proto-oncogene 1 Mus musculus 142-145 14749375-7 2004 In addition, our data show that PARP activity regulates the DNA binding activity of TRF2 via both a covalent heteromodification of the dimerization domain of TRF2 and a noncovalent binding of poly(ADP-ribose) to the myb domain of TRF2. Adenosine Diphosphate 197-200 poly(ADP-ribose) polymerase 1 Homo sapiens 32-36 14602724-4 2004 Here we report that insulin (0.5-200 nmol/liter) interferes with agonist-induced increases in [Ca(2+)](i) (ADP, thrombin), cAMP suppression (thrombin), and aggregation (ADP). Adenosine Diphosphate 169-172 insulin Homo sapiens 20-27 14602724-5 2004 The effects of insulin are as follows: (i) independent of the P2Y(12) receptor, which mediates ADP-induced cAMP lowering; (ii) not observed during G(s)-mediated cAMP formation; (iii) unaffected by treatments that affect phosphodiesterases (3-isobutyl-1-methylxanthine); and (iv) not changed by interfering with NO-mediated regulation of cAMP degradation (N(G)-monomethyl-l-arginine). Adenosine Diphosphate 95-98 insulin Homo sapiens 15-22 14706855-7 2004 By contrast, U46619 (10 microM), a stable analog of TXA(2), induced ERK2 activation in an ADP-dependent manner, via the P2Y12 receptor. Adenosine Diphosphate 90-93 mitogen-activated protein kinase 1 Homo sapiens 68-72 14706855-2 2004 In this report, we demonstrate that collagen-induced ERK2 activation depends on thromboxane A(2) (TXA(2)) formation and ADP release. Adenosine Diphosphate 120-123 mitogen-activated protein kinase 1 Homo sapiens 53-57 14706855-9 2004 Costimulation of the specific G(12/13)-coupled TXA(2) receptor with a low dose of U46619 (10 nM) and of Gi- and Gq-coupled ADP receptor (10 microM) induced very low levels of ERK2 activation, similar to those observed with ADP alone, suggesting that G(12/13) is not involved or not sufficient to induce the additional pathway necessary for ERK2 activation. Adenosine Diphosphate 123-126 mitogen-activated protein kinase 1 Homo sapiens 175-179 14706855-9 2004 Costimulation of the specific G(12/13)-coupled TXA(2) receptor with a low dose of U46619 (10 nM) and of Gi- and Gq-coupled ADP receptor (10 microM) induced very low levels of ERK2 activation, similar to those observed with ADP alone, suggesting that G(12/13) is not involved or not sufficient to induce the additional pathway necessary for ERK2 activation. Adenosine Diphosphate 123-126 mitogen-activated protein kinase 1 Homo sapiens 340-344 15258350-10 2004 PARP inhibitors reduced ADP-induced platelet aggregation in a dose-dependent manner (p<0.05). Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase 1 Homo sapiens 0-4 14728986-2 2004 Insulin secretion is coupled to glucose metabolism by effects of the intracellular ATP/ADP ratio on the multimeric beta-cell potassium channel. Adenosine Diphosphate 87-90 insulin Homo sapiens 0-7 14506231-7 2003 As a result, the attachment rate and completion of the power stroke or the equilibrium between actin.myosin.ADP states may define actin filament velocity for these myosin isoforms. Adenosine Diphosphate 108-111 Myosin heavy chain Drosophila melanogaster 101-107 15306153-3 2004 In a saline solution bubbled with CO, the increase of [Ca(2+)](i) produced by thrombin was 72+/-4% of the response evoked in the control solution (CO-free) and the response elicited by ADP was 64+/-8% of the control. Adenosine Diphosphate 185-188 coagulation factor II, thrombin Homo sapiens 78-86 15342215-1 2004 BACKGROUND: Thrombin downregulates endothelial ectonucleotidase activity resulting in high levels of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) which lead to platelet, leukocyte and endothelial activation. Adenosine Diphosphate 101-122 coagulation factor II, thrombin Homo sapiens 12-20 15342215-1 2004 BACKGROUND: Thrombin downregulates endothelial ectonucleotidase activity resulting in high levels of adenosine diphosphate (ADP) and adenosine triphosphate (ATP) which lead to platelet, leukocyte and endothelial activation. Adenosine Diphosphate 124-127 coagulation factor II, thrombin Homo sapiens 12-20 14697202-5 2003 We found that CFTR also has adenylate kinase activity (ATP + AMP <=> ADP + ADP) that regulates gating. Adenosine Diphosphate 75-78 CF transmembrane conductance regulator Homo sapiens 14-18 14697202-5 2003 We found that CFTR also has adenylate kinase activity (ATP + AMP <=> ADP + ADP) that regulates gating. Adenosine Diphosphate 81-84 CF transmembrane conductance regulator Homo sapiens 14-18 15342215-7 2004 RESULTS: Quercetin and resveratrol inhibited thrombin-induced ADP and ATP secretion from platelets in a concentration-dependent manner. Adenosine Diphosphate 62-65 coagulation factor II, thrombin Homo sapiens 45-53 14506231-7 2003 As a result, the attachment rate and completion of the power stroke or the equilibrium between actin.myosin.ADP states may define actin filament velocity for these myosin isoforms. Adenosine Diphosphate 108-111 Myosin heavy chain Drosophila melanogaster 164-170 15033737-2 2003 Exposure of T cells to NAD, the substrate for ART2-catalyzed ADP-ribosylation, induces exposure of phosphatidylserine, uptake of propidium iodide, and fragmentation of DNA. Adenosine Diphosphate 61-64 ADP-ribosyltransferase 1 Homo sapiens 46-50 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Diphosphate 97-100 interleukin 4 Homo sapiens 192-196 12842985-8 2003 A residual GPVI signal exists in the Btk-/-/Tec-/- platelets as CRP synergizes with ADP to mediate aggregation. Adenosine Diphosphate 84-87 tec protein tyrosine kinase Homo sapiens 44-47 14679173-3 2003 A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio and thus reduces the insulin-secretory response. Adenosine Diphosphate 144-147 insulin Homo sapiens 175-182 14675082-6 2003 Treatment of cells with agonists of platelet activation (ADP, epinephrine, and thrombin receptor-activating peptide) resulted in the release of VWF antigen and active FVIII into the supernatant from transduced cells. Adenosine Diphosphate 57-60 von Willebrand factor Homo sapiens 144-147 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Diphosphate 97-100 interferon gamma Homo sapiens 201-210 14637106-1 2003 Poly(ADP-ribose)polymerase-1 (PARP-1) is a nuclear enzyme activated by DNA breaks and serves a role in DNA repair through the formation of polymers (poly(ADP)ribosylation) at sites of DNA damage. Adenosine Diphosphate 4-8 poly(ADP-ribose) polymerase 1 Homo sapiens 30-36 14573867-2 2003 The crystal structures of bovine pancreatic ribonuclease A (RNase A) in complex with 3",5"-ADP, 2",5"-ADP, 5"-ADP, U-2"-p and U-3"-p have been determined at high resolution. Adenosine Diphosphate 90-94 ribonuclease pancreatic Bos taurus 44-58 14573867-2 2003 The crystal structures of bovine pancreatic ribonuclease A (RNase A) in complex with 3",5"-ADP, 2",5"-ADP, 5"-ADP, U-2"-p and U-3"-p have been determined at high resolution. Adenosine Diphosphate 90-94 ribonuclease pancreatic Bos taurus 60-67 14563321-0 2003 NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Adenosine Diphosphate 26-29 ADP-ribosyltransferase 1 Homo sapiens 71-75 14563321-0 2003 NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Adenosine Diphosphate 26-29 purinergic receptor P2X 7 Homo sapiens 100-104 14640259-7 2003 RESULTS: The platelets from women bound more fibrinogen in response to low and high concentrations of adenosine diphosphate. Adenosine Diphosphate 102-123 fibrinogen beta chain Homo sapiens 45-55 14511112-6 2003 BzATP, a potent P2X7 receptor agonist, was more effective than ATP, ADP, or 2-MeSATP at enhancing IFN gamma-induced ERK1/2 phosphorylation. Adenosine Diphosphate 68-71 interferon gamma Mus musculus 98-107 14527731-3 2003 At present, only a single enzyme, poly (ADP-ribose) glycohydrolase (PARG), has been identified to catalyze ADP-ribose polymer hydrolysis in the cell causing a rapid turnover of the biopolymer which may ultimately result in lethal depletion of cellular NAD(+) pools. Adenosine Diphosphate 40-43 poly(ADP-ribose) glycohydrolase Homo sapiens 68-72 12898701-8 2003 ADP and 2meSADP also produced [Ca(2+)](i) increases antagonized by the P2Y(1) antagonist MRS2179. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Rattus norvegicus 71-77 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 64-67 creatine kinase, muscle Mus musculus 0-4 14596595-7 2003 The affinities of several nucleotides (ATP, ADP, AMP, adenosine, and AMPPNP) to Sky1p and the prototype kinase, cAMP-dependent protein kinase, were compared in the absence and presence of the metal activator, Mg(2+), using a fluorescence-based displacement assay. Adenosine Diphosphate 44-47 serine/threonine protein kinase SKY1 Saccharomyces cerevisiae S288C 80-85 12911299-3 2003 By comparing the apoenzyme structure to the ADP- and ATP-bound Sky1p structures, we have revealed conformational changes caused by ATP binding or conversion from nucleotide reactant to product. Adenosine Diphosphate 44-47 serine/threonine protein kinase SKY1 Saccharomyces cerevisiae S288C 63-68 12911299-5 2003 In the apoenzyme, a kinase-conserved phosphate-anchoring loop is in a twisted conformation that is incompatible with ADP and ATP binding, providing a potential mechanism for facilitating ADP release in Sky1p. Adenosine Diphosphate 117-120 serine/threonine protein kinase SKY1 Saccharomyces cerevisiae S288C 202-207 12911299-5 2003 In the apoenzyme, a kinase-conserved phosphate-anchoring loop is in a twisted conformation that is incompatible with ADP and ATP binding, providing a potential mechanism for facilitating ADP release in Sky1p. Adenosine Diphosphate 187-190 serine/threonine protein kinase SKY1 Saccharomyces cerevisiae S288C 202-207 12796499-5 2003 U46619 stimulated phosphoinositide 3-kinase (PI3K)-dependent phosphorylation of Akt, which was augmented by ADP but did not require integrin outside-in signaling. Adenosine Diphosphate 108-111 thymoma viral proto-oncogene 1 Mus musculus 80-83 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 69-72 creatine kinase, muscle Mus musculus 0-4 12665468-6 2003 Toxin B, which inactivates Rho by ADP ribosylation, inhibits thrombin-induced SM alpha-actin organization, collagen gel contraction, and PKC-epsilon-SM alpha-actin and PKC-epsilon-RhoA coimmunoprecipitation. Adenosine Diphosphate 34-37 coagulation factor II, thrombin Homo sapiens 61-69 12889011-6 2003 Fibrinogen-adherent platelets exposed to thrombin generated the significantly highest exposure of CD62P and release of PF4, ADP, and ATP. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 0-10 12889011-6 2003 Fibrinogen-adherent platelets exposed to thrombin generated the significantly highest exposure of CD62P and release of PF4, ADP, and ATP. Adenosine Diphosphate 124-127 coagulation factor II, thrombin Homo sapiens 41-49 12889011-7 2003 When platelets were adhered to different protein coatings, von Willebrand factor generated the most CD62P exposure, IgG generated the most PF4 release, and thrombin generated the highest concentration of ADP. Adenosine Diphosphate 204-207 coagulation factor II, thrombin Homo sapiens 156-164 12740376-1 2003 The ADP/ATP carrier (AAC) that facilitates the translocation of ATP made in mitochondria is inserted at the inner mitochondrial membrane by the TIM10-TIM22 protein import system. Adenosine Diphosphate 4-7 protein transporter TIM10 Saccharomyces cerevisiae S288C 144-149 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 64-69 N-acetyl-alpha-glucosaminidase Homo sapiens 44-47 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 123-128 N-acetyl-alpha-glucosaminidase Homo sapiens 44-47 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 66-69 N-acetyl-alpha-glucosaminidase Homo sapiens 44-47 12802486-9 2003 Following incubation with propofol, platelets showed reduced binding of fibrinogen in the unstimulated and ADP-stimulated blood samples as well as a lower percentage of platelets with bound fibrinogen. Adenosine Diphosphate 107-110 fibrinogen beta chain Homo sapiens 72-82 12766240-1 2003 The pancreatic beta-cell type of ATP-sensitive potassium (KATP) channel (Kir6.2/SUR1) is inhibited by intracellular ATP and ADP, which bind to the Kir6.2 subunit, and is activated by Mg-nucleotide interaction with the regulatory sulphonylurea receptor subunits (SUR1). Adenosine Diphosphate 124-127 ATP-binding cassette sub-family C member 8 Xenopus laevis 80-84 12766240-1 2003 The pancreatic beta-cell type of ATP-sensitive potassium (KATP) channel (Kir6.2/SUR1) is inhibited by intracellular ATP and ADP, which bind to the Kir6.2 subunit, and is activated by Mg-nucleotide interaction with the regulatory sulphonylurea receptor subunits (SUR1). Adenosine Diphosphate 124-127 ATP-binding cassette sub-family C member 8 Xenopus laevis 262-266 12846829-10 2003 Secreted ADP plays a major role in GPIb-dependent thrombin-induced platelet activation which is, in addition, regulated by cAMP concentration. Adenosine Diphosphate 9-12 coagulation factor II, thrombin Homo sapiens 50-58 12767928-2 2003 Bcl-2 family proteins modulate the mitochondrial permeability through interaction with adenine nucleotide translocator (ANT), voltage-dependent anion channel (VDAC), ADP/ATP exchange, or oxidative phosphorylation during apoptosis. Adenosine Diphosphate 166-169 BCL2 apoptosis regulator Homo sapiens 0-5 12682054-5 2003 Increasing calcium above 10 microm slows both the rate of ADP release from S1 and HMM actomyosin VI and the rates of in vitro motility. Adenosine Diphosphate 58-61 proteasome 26S subunit, non-ATPase 1 Homo sapiens 75-99 12649291-6 2003 Unlike wild-type ART2a, ART2a(Y204R) was auto-ADP-ribosylated. Adenosine Diphosphate 46-49 ADP-ribosyltransferase 2b Rattus norvegicus 24-29 12782650-2 2003 Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. Adenosine Diphosphate 29-32 telomeric repeat binding factor 1 Homo sapiens 49-53 12782650-2 2003 Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. Adenosine Diphosphate 29-32 tankyrase Homo sapiens 57-68 12782650-2 2003 Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. Adenosine Diphosphate 29-32 telomeric repeat binding factor 1 Homo sapiens 78-82 12649291-10 2003 Thus, Arg204 in ART2b serves as a regulatory switch whose presence is required for additional auto-ADP-ribosylation and regulation of catalytic activity. Adenosine Diphosphate 99-102 ADP-ribosyltransferase 2b Rattus norvegicus 16-21 12681240-1 2003 Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. Adenosine Diphosphate 61-64 coagulation factor II Mus musculus 104-112 12676457-6 2003 Activated PARP-1 cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes the latter on nuclear acceptor proteins. Adenosine Diphosphate 54-57 poly(ADP-ribose) polymerase 1 Homo sapiens 10-16 12676650-9 2003 Glucose and methyl pyruvate stimulated 1.4- and 1.6-fold increases, respectively, in the ATP-to-ADP ratio in GIP/Ins cells. Adenosine Diphosphate 96-99 gastric inhibitory polypeptide Mus musculus 109-112 12853316-2 2003 Upon activation, the enzyme hydrolyzes NAD(+) to nicotinamide and transfers ADP ribose units to a variety of nuclear proteins, including histones and PARP-1 itself. Adenosine Diphosphate 76-79 poly(ADP-ribose) polymerase 1 Homo sapiens 150-156 12853316-12 2003 Studies demonstrating an important role for PARP-1 in the regulation of gene transcription have further increased the intricacy of poly(ADP-ribosyl)ation in the control of cell homeostasis and challenge the notion that energy collapse is the sole mechanism by which poly(ADP-ribose) formation contributes to cell death. Adenosine Diphosphate 136-139 poly(ADP-ribose) polymerase 1 Homo sapiens 44-50 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 215-236 heat shock protein family A (Hsp70) member 9 Homo sapiens 115-122 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 215-236 heat shock protein family A (Hsp70) member 9 Homo sapiens 249-256 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 238-241 heat shock protein family A (Hsp70) member 9 Homo sapiens 115-122 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 238-241 heat shock protein family A (Hsp70) member 9 Homo sapiens 249-256 12871418-7 2003 These results provide the direct evidence that, in human platelets, GPIbalpha and ADP act in synergy to amplify PAR1 coupled responses while PAR4 is activated independently of GPIbalpha and ADP. Adenosine Diphosphate 82-85 coagulation factor II thrombin receptor Homo sapiens 112-116 12668734-12 2003 Maximal shortening velocity of maximally activated, skinned smooth muscle preparations from SM-MHC-deficient mice was significantly lower and more sensitive to increased MgADP compared with velocity of SM-MHC-expressing preparations. Adenosine Diphosphate 170-175 myosin, heavy polypeptide 11, smooth muscle Mus musculus 92-98 12778366-1 2003 Prolactin is a newly recognized platelet coactivator that functions through potentiation of ADP-induced platelet activation. Adenosine Diphosphate 92-95 prolactin Homo sapiens 0-9 12637029-3 2003 NTPDase 1 hydrolyzed ATP and ADP following Michaelis-Menten kinetics with V=1278.7+/-38.4 nmol Pi/min/mg and K(M)=83.3+/-2.5 microM and V=473.9+/-18.9 nmol Pi/min/mg and K(M)=150.6+/-6.0 microM, respectively, but in the absence of magnesium and calcium ions, ATP or ADP hydrolysis was negligible. Adenosine Diphosphate 29-32 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 0-9 12649424-4 2003 However, the presence of ammonium sulfate and MgADP allows the fully unfolded GroEL to refold into a structure with the same hydrodynamic dimension, within experimental error, as that of the native GroEL. Adenosine Diphosphate 46-51 GroEL Escherichia coli 78-83 12649424-4 2003 However, the presence of ammonium sulfate and MgADP allows the fully unfolded GroEL to refold into a structure with the same hydrodynamic dimension, within experimental error, as that of the native GroEL. Adenosine Diphosphate 46-51 GroEL Escherichia coli 198-203 12649424-6 2003 These results demonstrate that the fully unfolded GroEL monomer can refold and reassemble into the native tetradecameric structure in the presence of ammonium sulfate and MgADP without ATP hydrolysis and preexisting chaperones. Adenosine Diphosphate 171-176 GroEL Escherichia coli 50-55 12640128-8 2003 We found that centrosomal p53 is poly(ADP-ribosyl)ated in vivo and centrosomal PARP-1 directly catalyzes poly(ADP-ribosyl)ation of p53 in vitro. Adenosine Diphosphate 37-41 tumor protein p53 Homo sapiens 26-29 12637029-3 2003 NTPDase 1 hydrolyzed ATP and ADP following Michaelis-Menten kinetics with V=1278.7+/-38.4 nmol Pi/min/mg and K(M)=83.3+/-2.5 microM and V=473.9+/-18.9 nmol Pi/min/mg and K(M)=150.6+/-6.0 microM, respectively, but in the absence of magnesium and calcium ions, ATP or ADP hydrolysis was negligible. Adenosine Diphosphate 266-269 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 0-9 12556353-12 2003 The increased activation of PDH was not explained by changes in muscle pyruvate or the ATP/ADP ratio but may be related to a decrease in the NADH/NAD(+) ratio or an epinephrine-induced increase in calcium concentration. Adenosine Diphosphate 91-94 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 28-31 12614151-3 2003 To gain further understanding of the determinants for efficient conversion by the enzyme thymidylate kinase (TMPK) of clinically important thymidine monophosphate analogues to the corresponding diphosphates, we solved the crystal structures of the enzyme, with either ADP or the ATP analogue AppNHp at the phosphoryl donor site, in complex with TMP, AZTMP (previous work), NH2TMP, d4TMP, ddTMP, and FLTMP (this work) at the phosphoryl acceptor site. Adenosine Diphosphate 268-271 deoxythymidylate kinase Homo sapiens 109-113 12431997-1 2003 Members of the BCL-2-related antiapoptotic family of proteins have been shown previously to regulate ATP/ADP exchange across the mitochondrial membranes and to prevent the loss of coupled mitochondrial respiration during apoptosis. Adenosine Diphosphate 105-108 BCL2 apoptosis regulator Homo sapiens 15-20 12488440-10 2003 This suggests that the coupled GAPDH/3-PGK system, which converts ADP to ATP, ensures maximal glutamate accumulation into presynaptic vesicles. Adenosine Diphosphate 66-69 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 31-36 12562963-3 2003 Intracellular MgADP modulated sulphonylurea block, enhancing inhibition of Kir6.2/SUR1 (beta-cell type) and decreasing that of Kir6.2/SUR2A (cardiac-type) channels. Adenosine Diphosphate 14-19 ATP-binding cassette sub-family C member 8 Xenopus laevis 82-86 12562963-6 2003 Our results indicate that transfer of the region containing transmembrane helices (TMs) 8-11 and the following 65 residues of SUR1 into SUR2A largely confers a SUR1-like response to MgADP and meglitinide, whereas the reverse chimera (SUR128) largely endows SUR1 with a SUR2A-type response. Adenosine Diphosphate 182-187 ATP-binding cassette sub-family C member 8 Xenopus laevis 126-130 12562963-6 2003 Our results indicate that transfer of the region containing transmembrane helices (TMs) 8-11 and the following 65 residues of SUR1 into SUR2A largely confers a SUR1-like response to MgADP and meglitinide, whereas the reverse chimera (SUR128) largely endows SUR1 with a SUR2A-type response. Adenosine Diphosphate 182-187 ATP-binding cassette sub-family C member 8 Xenopus laevis 160-164 12562963-6 2003 Our results indicate that transfer of the region containing transmembrane helices (TMs) 8-11 and the following 65 residues of SUR1 into SUR2A largely confers a SUR1-like response to MgADP and meglitinide, whereas the reverse chimera (SUR128) largely endows SUR1 with a SUR2A-type response. Adenosine Diphosphate 182-187 ATP-binding cassette sub-family C member 8 Xenopus laevis 160-164 12562963-8 2003 The data favour the idea that meglitinide binding to SUR1 impairs either MgADP binding or the transduction pathway between the NBDs and Kir6.2, and that TMs 8-11 are involved in this modulatory response. Adenosine Diphosphate 73-78 ATP-binding cassette sub-family C member 8 Xenopus laevis 53-57 12475993-11 2003 In contrast, overexpression of Mcl-1 proteins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-interacting protein. Adenosine Diphosphate 61-64 telomeric repeat binding factor 1 Homo sapiens 85-118 12475993-11 2003 In contrast, overexpression of Mcl-1 proteins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-interacting protein. Adenosine Diphosphate 61-64 tankyrase Homo sapiens 128-139 12446697-7 2003 The microtubule-activated steady-state ATPase cycle of Kar3 (k(cat) = 0.5 s(-1)) is limited by ADP release (0.4 s(-1)). Adenosine Diphosphate 95-98 Kar3p Saccharomyces cerevisiae S288C 55-59 12458196-0 2003 ATP binding, not hydrolysis, at the first nucleotide-binding domain of multidrug resistance-associated protein MRP1 enhances ADP.Vi trapping at the second domain. Adenosine Diphosphate 125-128 ATP binding cassette subfamily C member 1 Homo sapiens 111-115 12458196-2 2003 We found that ATP binding to the first NBD of MRP1 increases binding and trapping of ADP at the second domain (Hou, Y., Cui, L., Riordan, J. R., and Chang, X. Adenosine Diphosphate 85-88 ATP binding cassette subfamily C member 1 Homo sapiens 46-50 12458196-11 2003 4) In contrast, the hexokinase-treated poorly hydrolyzable ATP analogue, adenosine 5"-O-(thiotriphosphate) (ATPgammaS), enhances ADP trapping to a similar extent as ATP under conditions in which ATPgammaS should not be hydrolyzed. Adenosine Diphosphate 129-132 hexokinase 1 Homo sapiens 20-30 12549939-5 2003 Both resting and transition state P-glycoprotein showed similar affinity for TNP-ATP/TNP-ADP and unlabeled ATP/ADP. Adenosine Diphosphate 89-92 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 12549939-5 2003 Both resting and transition state P-glycoprotein showed similar affinity for TNP-ATP/TNP-ADP and unlabeled ATP/ADP. Adenosine Diphosphate 111-114 ATP binding cassette subfamily B member 1 Homo sapiens 34-48 12549939-8 2003 These results indicate that both nucleotide binding domains of P-glycoprotein are likely to be occupied with either ATP (or ADP) in the resting state and the transition state in the absence of transport substrates. Adenosine Diphosphate 124-127 ATP binding cassette subfamily B member 1 Homo sapiens 63-77 12549939-9 2003 Drugs alter the binding affinity to favor association of ATP with P-glycoprotein at the start of the catalytic cycle and release of ADP from the transition state following nucleotide hydrolysis. Adenosine Diphosphate 132-135 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 12547721-9 2003 For normal pregnancy, tumor necrosis factor-alpha and depleted oxygen significantly increased TUNEL, Annexin V binding and ADP:ATP in CTs and syncytiotrophoblasts (STs). Adenosine Diphosphate 123-126 tumor necrosis factor Homo sapiens 22-49 12595854-6 2003 With ACE inhibition, platelet aggregation decreased by 33% (P =.042) after ADP induction. Adenosine Diphosphate 75-78 angiotensin I converting enzyme Homo sapiens 5-8 12571754-7 2003 Moreover, RT-PCR analysis showed that TRPM2 was abundantly expressed in CRI-G1 cells, suggesting that the ADP-ribose-gated channel represents the native TRPM2 channel in CRI-G1 cells. Adenosine Diphosphate 106-109 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 38-43 12571754-7 2003 Moreover, RT-PCR analysis showed that TRPM2 was abundantly expressed in CRI-G1 cells, suggesting that the ADP-ribose-gated channel represents the native TRPM2 channel in CRI-G1 cells. Adenosine Diphosphate 106-109 transient receptor potential cation channel, subfamily M, member 2 Rattus norvegicus 153-158 12519059-3 2003 In vitro inhibition of PARP-1 was confirmed by direct measurement of NAD+ depletion and ADP-ribose polymer formation caused by chemically induced DNA damage. Adenosine Diphosphate 88-91 poly(ADP-ribose) polymerase 1 Homo sapiens 23-29 12543814-1 2003 Bcl-2 is a prosurvival factor that reportedly prevents the nonspecific permeabilization of mitochondrial membranes, yet enhances specific ADP/ATP exchange by these organelles. Adenosine Diphosphate 138-141 BCL2 apoptosis regulator Homo sapiens 0-5 12543814-2 2003 Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in intact cells in which mitochondrial matrix ATP was monitored continuously using a specific luciferase-based assay system. Adenosine Diphosphate 38-41 BCL2 apoptosis regulator Homo sapiens 19-24 12543814-3 2003 Conversely, Bax, which displaces Bcl-2 from ANT in apoptotic cells, inhibits ADP/ATP exchange through a direct action on ANT. Adenosine Diphosphate 77-80 BCL2 associated X, apoptosis regulator Homo sapiens 12-15 12543814-3 2003 Conversely, Bax, which displaces Bcl-2 from ANT in apoptotic cells, inhibits ADP/ATP exchange through a direct action on ANT. Adenosine Diphosphate 77-80 BCL2 apoptosis regulator Homo sapiens 33-38 12543814-4 2003 The Bax-mediated inhibition of ADP/ATP exchange can be separated from Bax-stimulated formation of nonspecific pores by ANT. Adenosine Diphosphate 31-34 BCL2 associated X, apoptosis regulator Homo sapiens 4-7 12407113-5 2003 However, in platelets from PI3Kgamma-deficient mice, both ADP and epinephrine were still able to normally stimulate Rap1B activation through a PI3K-dependent mechanism, suggesting the involvement of a different isoform of the enzyme. Adenosine Diphosphate 58-61 RAS related protein 1b Mus musculus 116-121 14713113-5 2003 Respiration of isolated heart mitochondria follows hyperbolic oxygen kinetics with half-saturating oxygen pressure, p50, of 0.04 kPa (0.3 Torr; 0.4 microM) in ADP-stimulated state 3. Adenosine Diphosphate 159-162 nuclear factor kappa B subunit 1 Homo sapiens 116-119 12698015-2 2003 Clopidogrel and ticlopidine are adenosine diphosphate (ADP)-receptor antagonists that inhibit ADP-induced fibrinogen binding to platelets, a necessary step in the platelet aggregation process. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 106-116 12818251-8 2003 This effect was further enhanced in carriers of the GPIIIa Pl(A2) allele (2 microM ADP: 42% vs. 19%, p=0.017; 1 microM U-46619: 51% vs. 30%, p=0.03; 5 microM epinephrine: 69% vs. 53%, p=0.025). Adenosine Diphosphate 83-86 integrin subunit beta 3 Homo sapiens 52-58 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 0-3 14529392-2 2003 Coactivation of the Galphaq-coupled P2Y1 and Galphai2-coupled P2Y12 receptors is necessary for ADP-mediated platelet activation, which forms the basis of using P2 antagonists as antithrombotic drugs. Adenosine Diphosphate 95-98 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 45-53 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 4-7 proteasome 26S subunit, non-ATPase 1 Homo sapiens 0-3 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 102-105 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 0-3 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 102-105 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 102-105 14870966-10 2003 S-1.ADP.Pi (weak binding) was not affected by caldesmon concentrations giving 80% inhibition, however S-1.ADP (strong binding) was highly cooperative, being very weak at <0.3 microM but indistinguishable from uninhibited actin at >2 microM S-1.ADP. Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 102-105 14640903-1 2003 Enzymes that hydrolyze extracellular ATP, i.e. ecto-ATPase and ecto-ATP diphosphohydrolase (ATPDase), can be differentiated by ability of the latter to hydrolyze ADP and by slightly different kinetic properties of the two enzymes. Adenosine Diphosphate 162-165 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 63-90 14535829-4 2003 More importantly, we show that in both cell lines, Bcl-2 inhibits mitochondrial respiration and causes a decrease of the ATP/ADP ratio. Adenosine Diphosphate 125-128 BCL2 apoptosis regulator Homo sapiens 51-56 14644082-5 2003 The relative inhibition of the thrombin response by complete inhibition of P2Y(12) was most pronounced at thrombin concentrations just enough for complete PAR1 cleavage, which is sufficient to release all ADP, giving 70-86% inhibition. Adenosine Diphosphate 205-208 coagulation factor II, thrombin Homo sapiens 31-39 14644082-5 2003 The relative inhibition of the thrombin response by complete inhibition of P2Y(12) was most pronounced at thrombin concentrations just enough for complete PAR1 cleavage, which is sufficient to release all ADP, giving 70-86% inhibition. Adenosine Diphosphate 205-208 coagulation factor II thrombin receptor Homo sapiens 155-159 12937839-5 2003 p53 phosphorylated on Ser-392 was also increased by approximately 70% in patients treated with radiotherapy and with chemotherapy and correlated with elevated poly-ADP-ribose levels. Adenosine Diphosphate 164-167 tumor protein p53 Homo sapiens 0-3 14640903-1 2003 Enzymes that hydrolyze extracellular ATP, i.e. ecto-ATPase and ecto-ATP diphosphohydrolase (ATPDase), can be differentiated by ability of the latter to hydrolyze ADP and by slightly different kinetic properties of the two enzymes. Adenosine Diphosphate 162-165 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 92-99 12628300-5 2002 The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity. Adenosine Diphosphate 26-29 poly(ADP-ribose) glycohydrolase Homo sapiens 182-186 12477353-1 2002 Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. Adenosine Diphosphate 14-17 purinergic receptor P2Y1 Rattus norvegicus 26-32 12477353-1 2002 Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. Adenosine Diphosphate 14-17 purinergic receptor P2Y1 Rattus norvegicus 26-29 12477353-4 2002 For the known nucleotide (cyclic and acyclic) bisphosphate antagonists of P2Y(1) receptors, there was a significant correlation between inhibition of aggregation induced by 3.3 microM ADP in rat platelets and inhibition of P2Y(1) receptor-induced phospholipase C (PLC) activity previously determined in turkey erythrocytes. Adenosine Diphosphate 184-187 purinergic receptor P2Y1 Rattus norvegicus 74-77 12477353-4 2002 For the known nucleotide (cyclic and acyclic) bisphosphate antagonists of P2Y(1) receptors, there was a significant correlation between inhibition of aggregation induced by 3.3 microM ADP in rat platelets and inhibition of P2Y(1) receptor-induced phospholipase C (PLC) activity previously determined in turkey erythrocytes. Adenosine Diphosphate 184-187 purinergic receptor P2Y1 Rattus norvegicus 223-226 12356756-6 2002 BAP stimulated the ATPase activity of BiP when added alone or together with the ER DnaJ protein, ERdj4, by promoting the release of ADP from BiP. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 5 Homo sapiens 38-41 12356756-6 2002 BAP stimulated the ATPase activity of BiP when added alone or together with the ER DnaJ protein, ERdj4, by promoting the release of ADP from BiP. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 5 Homo sapiens 141-144 12482826-8 2002 Only in the presence of depolarized HUVECs, but not with control cells or with HUVECs depolarized in the presence of SOD, did 5 micromol/L of ADP cause irreversible platelet aggregation. Adenosine Diphosphate 142-145 superoxide dismutase 1 Homo sapiens 117-120 12628300-5 2002 The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity. Adenosine Diphosphate 116-119 poly(ADP-ribose) glycohydrolase Homo sapiens 18-22 12628300-5 2002 The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity. Adenosine Diphosphate 116-119 poly(ADP-ribose) glycohydrolase Homo sapiens 182-186 12628300-5 2002 The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity. Adenosine Diphosphate 116-119 poly(ADP-ribose) glycohydrolase Homo sapiens 18-22 12628300-5 2002 The inhibition of PARG or ADP-ribose-degrading enzymes allowed the demonstration that in vitro synthesized 32P-poly(ADP-ribose) is first digested to ADP-ribose monomers by a typical PARG reaction, and that ADP-ribose is further rapidly converted into AMP by an Mg(2+)-dependent activity. Adenosine Diphosphate 116-119 poly(ADP-ribose) glycohydrolase Homo sapiens 182-186 12628300-6 2002 Collectively, our results demonstrate the ability of the human cell post-nuclear fraction to convert synthetic poly(ADP-ribose) into utilizable AMP units by the concerted action of PARG and ADP-ribose-degrading activities. Adenosine Diphosphate 116-119 poly(ADP-ribose) glycohydrolase Homo sapiens 181-185 12228733-6 2002 Agents that disrupt the mitochondrial outer membrane, such as digitonin, or maintain outer membrane exchange of adenine nucleotide, such as Bcl-x(L), restored ADP-dependent control of mitochondrial respiration. Adenosine Diphosphate 159-162 BCL2 like 1 Homo sapiens 140-148 12423666-7 2002 P2Y(1) receptor-selective adenine nucleotides, including 2-MeSADP and ADP, also induced concentration-dependent phosphorylation and hence, activation of the extracellular-signal regulated protein kinases (ERK1/2). Adenosine Diphosphate 62-65 mitogen-activated protein kinase 3 Homo sapiens 205-211 12138101-9 2002 The interaction of extracellular ATP and/or ADP with P2Y(1) purinergic receptors therefore plays a role in the response of HTC cells to osmotic swelling but does not account for activation of all the efflux pathways involved in the volume-regulatory response. Adenosine Diphosphate 44-47 purinergic receptor P2Y1 Rattus norvegicus 53-59 12379473-3 2002 A thiamine diphosphate (ThDP) kinase (ThDP+ATP if ThTP+ADP) has been purified from brewer"s yeast and shown to exist in rat liver. Adenosine Diphosphate 55-58 thiamine triphosphatase Homo sapiens 50-54 12239162-6 2002 We found that the antagonism of P2X(1) with ADP or desensitization of this ion channel with alpha,beta-methylene ATP both resulted in impaired ERK2 phosphorylation, ATP secretion, and platelet aggregation induced by low concentrations of collagen (< or = 1 microg/mL) without affecting the minor early dense granule release. Adenosine Diphosphate 44-47 mitogen-activated protein kinase 1 Homo sapiens 143-147 12408998-6 2002 Kistrin (10-30 nmol/l) inhibited ADP- and collagen-induced aggregation stronger in Pl(A2)(-) donors than in Pl(A2)(+) donors; there was a significant difference between 50% inhibitory concentrations (IC(50)). Adenosine Diphosphate 33-36 phospholipase A2 group IB Homo sapiens 83-88 12428106-4 2002 Analysis of integrin alpha(2)beta(1)-dependent platelet adhesion to collagen indicated that ADP-induced suppression of platelet adhesion is the result of trans-dominant inhibition of integrin alpha(2)beta(1) caused by fibrinogen binding to integrin GPIIb-IIIa. Adenosine Diphosphate 92-95 fibrinogen beta chain Homo sapiens 218-228 12183336-14 2002 Simultaneous blockade of the P2Y(1) and P2Y(12) receptors, and inhibition of cyclo-oxygenase demonstrated that CRP can activate platelets independently of ADP and TxA(2); however, responses to the collagens were dependent on these mediators. Adenosine Diphosphate 155-158 C-reactive protein Homo sapiens 111-114 12213594-2 2002 In order to analyze the role of Rho proteins in TNF-alpha-induced NF-kappaB-activation in human umbilical cord vein endothelial cells (HUVEC) we used Clostridium difficile toxin B-10463 (TcdB-10463) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium botulinum C3-toxin which inhibits RhoA/B/C by ADP-ribosylation. Adenosine Diphosphate 312-315 tumor necrosis factor Homo sapiens 48-57 12356871-5 2002 Binding of Hsp70-ADP to CD40 is strongly increased in the presence of Hsp70 peptide substrate, and induces signaling via p38. Adenosine Diphosphate 17-20 mitogen-activated protein kinase 14 Homo sapiens 121-124 12181138-16 2002 These findings suggest that the nascent EDHF dependency of ADP-induced pial arteriolar dilation in Ovx females involves connexin43-related gap junctional communication. Adenosine Diphosphate 59-62 gap junction protein, alpha 1 Rattus norvegicus 120-130 12440774-1 2002 Mammalian poly(ADP-ribose)polymerase 1 (PARP-1) is an abundant nuclear chromatin-associated protein and belongs to a large family of enzymes that catalyzes the transfer of ADP-ribose units from its substrate beta-nicotinamide adenine dinucleotide (NAD+) covalently to itself and other nuclear chromatin-associated proteins. Adenosine Diphosphate 15-18 poly(ADP-ribose) polymerase 1 Homo sapiens 40-46 12482360-5 2002 The ScFv fragment could inhibit ADP-induced platelets aggregation in a dose-dependent manner in vitro and the maximal inhibition rate was obtained at a concentration of 20 micro g/ml. Adenosine Diphosphate 32-35 immunglobulin heavy chain variable region Homo sapiens 4-8 12479880-7 2002 Insulin also enhanced ADP-induced platelet aggregation, seen as an augmented decrease of single platelet counts. Adenosine Diphosphate 22-25 insulin Homo sapiens 0-7 12479880-8 2002 Insulin (30 microU/ml) increased leukocyte CD11b mean fluorescence intensity (MFI) in unstimulated, as well as fMLP- and ADP-stimulated samples (P<0.05 for all). Adenosine Diphosphate 121-124 insulin Homo sapiens 0-7 12198249-7 2002 However, the stimulatory effects of 0.2 mM ADP on SUR1/Kir6.2 currents were reduced by 26.7 +/- 2.9% (P < 0.05) in the presence of cPKA. Adenosine Diphosphate 43-46 ATP binding cassette subfamily C member 8 Rattus norvegicus 50-54 12198249-9 2002 The point mutation S1448A in the ADP-sensing region of SUR1 removed the modulatory effects of cPKA. Adenosine Diphosphate 33-36 ATP binding cassette subfamily C member 8 Rattus norvegicus 55-59 12198249-10 2002 Our results indicate that PKA-mediated phosphorylation of S1448 in the SUR1 subunit leads to K(ATP) channel closure via an ADP-dependent mechanism. Adenosine Diphosphate 123-126 ATP binding cassette subfamily C member 8 Rattus norvegicus 71-75 12413586-10 2002 the effects exerted by insulin aspart on both cyclic nucleotides (ANOVA, p=0.0001) were more prolonged than those exerted by regular insulin; (iv) like human regular insulin, insulin aspart significantly decreased platelet response to ADP (ANOVA, p=0.0001): after 60 min of incubation, the anti-aggregating effect exerted by insulin aspart was significantly greater than that exerted by human regular insulin (p=0.027). Adenosine Diphosphate 235-238 insulin Homo sapiens 23-30 12145809-18 2002 Acute exposure stimulates somatostatin mediated by ADP ribosylation, whereas long-term exposure reduces cellular responses to stimuli. Adenosine Diphosphate 51-54 somatostatin Oryctolagus cuniculus 26-38 12110661-4 2002 UCP2 has also been suggested to regulate the [ATP]/[ADP] ratio and was recently shown to influence insulin secretion in the beta-cells of the pancreas. Adenosine Diphosphate 52-55 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 0-4 12189015-9 2002 The percentage of ADP-induced platelet aggregation decreased as a function of peroxynitrite-mediated modification of fibrinogen molecule. Adenosine Diphosphate 18-21 fibrinogen beta chain Homo sapiens 117-127 12111807-10 2002 Pretreatment with cyclosporin A or ADP plus oligomycin prevented the deleterious effects promoted by A beta and/or Ca(2+). Adenosine Diphosphate 35-38 amyloid beta precursor protein Homo sapiens 101-107 12169627-5 2002 The S1R mutation in SUR1, SUR2A or SUR2B reduced K(ATP) current activation by 100 microM MgADP, whereas the S2R mutation in SUR1 or SUR2B (but not SUR2A) abolished MgADP activation completely. Adenosine Diphosphate 89-94 ATP-binding cassette sub-family C member 8 Xenopus laevis 20-24 12034727-11 2002 Finally, vanadate-induced trapping of ADP inhibited [125I]LY475776 labeling, suggesting that ATP hydrolysis causes a conformational change in MRP1 that reduces the affinity of the protein for this inhibitor. Adenosine Diphosphate 38-41 ATP binding cassette subfamily B member 1 Homo sapiens 142-146 12011073-1 2002 Poly(ADP-ribose) polymerase-1 (PARP-1) is activated by DNA strand breaks during cellular genotoxic stress response and catalyzes poly(ADP-ribosyl)ation of acceptor proteins. Adenosine Diphosphate 4-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-37 12084057-3 2002 For AAC1 and AAC2 from rat, apparent Km values of about 40 microm for ADP, and 105 microm or 140 microm, respectively, for ATP have been determined, similar to the data reported for isolated rat mitochondria. Adenosine Diphosphate 70-73 ADP/ATP carrier 1 Arabidopsis thaliana 4-8 12297334-2 2002 EEF-2 was measured in rat heart extracts and isolated rat cardiomyocytes (CM) from newborn and adult rats using sodium-dodecylsulphate polyacrylamide gel electrophoresis after specific labeling with [32P]ADP-ribosylation or immunoblot. Adenosine Diphosphate 204-207 eukaryotic translation elongation factor 2 Rattus norvegicus 0-5 12096063-0 2002 Myosin light chain 2 modulates MgADP-induced contraction in rabbit skeletal and bovine cardiac skinned muscle. Adenosine Diphosphate 31-36 myosin regulatory light chain 2, ventricular/cardiac muscle isoform Oryctolagus cuniculus 0-20 12096063-3 2002 To investigate whether muscle regulatory proteins, myosin light chain 2 (LC2) and troponin C (TnC), play a part in the MgADP-induced contraction, these proteins were partly extracted by treatment with trans-1,2-cyclohexanediamine-N,N,N",N"-tetraacetic acid (CDTA), a chelater of divalent cations, and the MgADP-tension relationship was examined in rabbit psoas and bovine cardiac skinned fibres. Adenosine Diphosphate 119-124 myosin regulatory light chain 2, ventricular/cardiac muscle isoform Oryctolagus cuniculus 51-71 12054687-5 2002 ADP was more potent against IkappaBalpha phosphorylation as compared to autophosphorylation, while the peptide inhibitor showed the opposite effect. Adenosine Diphosphate 0-3 NFKB inhibitor alpha Homo sapiens 28-40 12051667-1 2002 Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to genotoxic insults by binding damaged DNA and attaching polymers of ADP-ribose to nuclear proteins at the expense of its substrate NAD+. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 29-33 11916974-4 2002 We now show that Cdc37p/p50(cdc37), like Sti1/Hop/p60, also suppresses ATP turnover by Hsp90 supporting the idea that client protein loading to Hsp90 requires a "relaxed" ADP-bound conformation. Adenosine Diphosphate 171-174 nuclear factor kappa B subunit 1 Homo sapiens 24-27 12057768-11 2002 Together these data suggest that C5a-mediated AP-1 activation requires both the activation of the ERK and JNK pathways, whereas activation of the JNK pathway is sufficient to increase AP-1 binding with ADP. Adenosine Diphosphate 202-205 complement C5a receptor 1 Homo sapiens 33-36 12057768-11 2002 Together these data suggest that C5a-mediated AP-1 activation requires both the activation of the ERK and JNK pathways, whereas activation of the JNK pathway is sufficient to increase AP-1 binding with ADP. Adenosine Diphosphate 202-205 mitogen-activated protein kinase 8 Homo sapiens 146-149 12355033-5 2002 Platelet reactivity was characterized with flow cytometry to quantify the percentage of platelets capable of binding fibrinogen (activation of glycoprotein IIb-IIIa) and expressing P-selectin in response to adenosine diphosphate (ADP, 0, 0.2, and 1 microM). Adenosine Diphosphate 207-228 fibrinogen beta chain Homo sapiens 117-127 12355033-6 2002 RESULTS: Platelet reactivity was greater in blood treated with UFH than in blood anticoagulated with bivalirudin with respect to both the capacity to bind fibrinogen (by 4 +/- 1.8%, p = 0.01) and P-selectin expression (by 7.7 +/- 0.7%, p, < 0.0001) in response to 1 microM ADP. Adenosine Diphosphate 276-279 fibrinogen beta chain Homo sapiens 155-165 12189020-10 2002 The results suggest that fibrinogen on the surface of Synthocytes can interact with GPIIb/IIIa on platelets to induce platelet activation, secretory activity and aggregation, and that ADP contributes to this process. Adenosine Diphosphate 184-187 fibrinogen beta chain Homo sapiens 25-35 12054687-10 2002 In contrast, ADP showed equipotent inhibition against the S176E/S180E mutant-catalyzed autophosphorylation and IkappaBalpha phosphorylation reactions. Adenosine Diphosphate 13-16 NFKB inhibitor alpha Homo sapiens 111-123 12082629-9 2002 Incubation of rho(0) cells with ADP+Pi to increase intracellular ATP restored sensitivity to TRAIL. Adenosine Diphosphate 32-35 TNF superfamily member 10 Homo sapiens 93-98 12015420-7 2002 Purified PKC inhibited Kir6.1/SUR2B activity (in 0.5 mM ATP/ 0.5 mM ADP), and the inhibition was blocked by a specific peptide inhibitor of PKC, PKC(19-31). Adenosine Diphosphate 68-71 proline rich transmembrane protein 2 Homo sapiens 140-143 12015420-7 2002 Purified PKC inhibited Kir6.1/SUR2B activity (in 0.5 mM ATP/ 0.5 mM ADP), and the inhibition was blocked by a specific peptide inhibitor of PKC, PKC(19-31). Adenosine Diphosphate 68-71 proline rich transmembrane protein 2 Homo sapiens 140-143 11986217-9 2002 We conclude that (1) thrombin- and thrombin receptor-activating peptide-induced inhibition of adenylyl cyclase in platelets depends exclusively on secreted adenosine diphosphate that stimulates G(i) signaling pathways and (2) thrombin and thrombin receptor-activating peptides cause platelet aggregation independently of G(i) signaling. Adenosine Diphosphate 156-177 coagulation factor II, thrombin Homo sapiens 21-29 11986217-9 2002 We conclude that (1) thrombin- and thrombin receptor-activating peptide-induced inhibition of adenylyl cyclase in platelets depends exclusively on secreted adenosine diphosphate that stimulates G(i) signaling pathways and (2) thrombin and thrombin receptor-activating peptides cause platelet aggregation independently of G(i) signaling. Adenosine Diphosphate 156-177 coagulation factor II, thrombin Homo sapiens 35-43 11986217-9 2002 We conclude that (1) thrombin- and thrombin receptor-activating peptide-induced inhibition of adenylyl cyclase in platelets depends exclusively on secreted adenosine diphosphate that stimulates G(i) signaling pathways and (2) thrombin and thrombin receptor-activating peptides cause platelet aggregation independently of G(i) signaling. Adenosine Diphosphate 156-177 coagulation factor II, thrombin Homo sapiens 35-43 11986217-9 2002 We conclude that (1) thrombin- and thrombin receptor-activating peptide-induced inhibition of adenylyl cyclase in platelets depends exclusively on secreted adenosine diphosphate that stimulates G(i) signaling pathways and (2) thrombin and thrombin receptor-activating peptides cause platelet aggregation independently of G(i) signaling. Adenosine Diphosphate 156-177 coagulation factor II, thrombin Homo sapiens 35-43 12015420-7 2002 Purified PKC inhibited Kir6.1/SUR2B activity (in 0.5 mM ATP/ 0.5 mM ADP), and the inhibition was blocked by a specific peptide inhibitor of PKC, PKC(19-31). Adenosine Diphosphate 68-71 proline rich transmembrane protein 2 Homo sapiens 9-12 11903050-3 2002 The major allosteric activator and inhibitor are ADP and GTP, respectively; allosteric activation by leucine may play an important role in amino acid-stimulated insulin secretion. Adenosine Diphosphate 49-52 insulin Homo sapiens 161-168 11861646-8 2002 We have now characterized the interactions of the 8-azido-photoactive analogues of ATP, ADP, and 5"-adenyl-beta,gamma-imidodiphosphate (AMP-PNP) with the two domains of functional membrane-bound CFTR. Adenosine Diphosphate 88-91 CF transmembrane conductance regulator Homo sapiens 195-199 12180497-10 2002 ADP, ristocetin and thrombin induce fibrinogen binding to porcine platelets similarly to human platelets. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 36-46 11943809-0 2002 ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. Adenosine Diphosphate 0-3 interleukin 1 beta Mus musculus 19-36 11943809-0 2002 ADP and AMP induce interleukin-1beta release from microglial cells through activation of ATP-primed P2X7 receptor channels. Adenosine Diphosphate 0-3 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 100-113 12182905-8 2002 RESULTS: Insulin enhanced ADP-induced platelet fibrinogen binding in both Type 1 DM patients and healthy subjects. Adenosine Diphosphate 26-29 insulin Homo sapiens 9-16 12182905-8 2002 RESULTS: Insulin enhanced ADP-induced platelet fibrinogen binding in both Type 1 DM patients and healthy subjects. Adenosine Diphosphate 26-29 fibrinogen beta chain Homo sapiens 47-57 12182905-9 2002 For example, ADP-stimulated platelet fibrinogen BI increased from 4.25 +/- 0.74 to 8.63 +/- 2.00 with 10 microU/ml insulin (P < .05) in Type 1 DM patients. Adenosine Diphosphate 13-16 fibrinogen beta chain Homo sapiens 37-47 12182905-9 2002 For example, ADP-stimulated platelet fibrinogen BI increased from 4.25 +/- 0.74 to 8.63 +/- 2.00 with 10 microU/ml insulin (P < .05) in Type 1 DM patients. Adenosine Diphosphate 13-16 insulin Homo sapiens 115-122 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 89-92 X-prolyl aminopeptidase 1 Homo sapiens 57-61 11839740-9 2002 We could detect ADP --> ATP exchange in the high affinity ADP binding mode (K(app1)) but not the low affinity binding mode (K(app2)). Adenosine Diphosphate 16-19 X-prolyl aminopeptidase 1 Homo sapiens 81-85 11839740-9 2002 We could detect ADP --> ATP exchange in the high affinity ADP binding mode (K(app1)) but not the low affinity binding mode (K(app2)). Adenosine Diphosphate 61-64 X-prolyl aminopeptidase 1 Homo sapiens 81-85 11929769-4 2002 In contrast, we now show that NTPDase2 (CD39L1, 75 kd), a preferential nucleoside triphosphatase, activates platelet aggregation by converting adenosine triphosphate (ATP) to ADP, the specific agonist of P2Y(1) and P2Y(12) receptors. Adenosine Diphosphate 175-178 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 30-38 11929769-4 2002 In contrast, we now show that NTPDase2 (CD39L1, 75 kd), a preferential nucleoside triphosphatase, activates platelet aggregation by converting adenosine triphosphate (ATP) to ADP, the specific agonist of P2Y(1) and P2Y(12) receptors. Adenosine Diphosphate 175-178 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 40-46 11943809-5 2002 However, when ADP and AMP, but not UTP or adenosine, were applied after a brief exposure to ATP or BzATP, they activated P2X(7) receptors in a dose-dependent manner. Adenosine Diphosphate 14-17 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 121-127 11943809-9 2002 Finally, ADP and AMP stimulated the release of interleukin-1beta from ATP-primed mouse and human microglial cells. Adenosine Diphosphate 9-12 interleukin 1 beta Mus musculus 47-64 11943809-10 2002 We conclude that selective sensitization of P2X(7) receptors to ADP and AMP requires priming with ATP. Adenosine Diphosphate 64-67 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 44-50 12023860-2 2002 The respiration of isolated heart mitochondria is a hyperbolic function of oxygen concentration and half-maximal rates were obtained at 0.4 and 0.7 microM O(2) with substrates for the respiratory chain (succinate) and cytochrome c oxidase [N,N,N,N",N"-tetramethyl-p-phenylenediamine dihydrochloride (TMPD)+ascorbate] respectively at 30 degrees C and with maximum ADP stimulation (State 3). Adenosine Diphosphate 363-366 cytochrome c, somatic Homo sapiens 218-230 11895777-8 2002 Specifically, Lyn is required under these conditions to enable thrombin-induced TxA2 production and adenosine diphosphate secretion, necessary steps in secretion-dependent platelet aggregation. Adenosine Diphosphate 100-121 coagulation factor II Mus musculus 63-71 11991544-2 2002 During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO2max) and is regulated by increases in Ca2+, free ADP, and pyruvate concentrations. Adenosine Diphosphate 190-193 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 17-39 12149566-4 2002 Thrombin generation in vivo was associated with ex vivo platelet desensitization to adenosine 5"-diphosphate and collagen-induced aggregation. Adenosine Diphosphate 84-108 coagulation factor II Rattus norvegicus 0-8 11867522-0 2002 The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. Adenosine Diphosphate 67-70 translocase of inner mitochondrial membrane 9 Homo sapiens 4-9 11914651-2 2002 We here report that washed platelets supplemented with prothrombin can be irreversibly aggregated with otherwise non-aggregant doses of adenosine diphosphate (10 micromol/l), thrombin (0.06 U/ml), or collagen (1 microg/ml). Adenosine Diphosphate 136-157 coagulation factor II, thrombin Homo sapiens 58-66 11867522-6 2002 The Tim9p-Tim10p complex bound specifically to the transmembrane domains of the ADP/ATP carrier, but had no affinity for Tim23p, an inner membrane protein that is inserted via the TIM22 complex. Adenosine Diphosphate 80-83 translocase of inner mitochondrial membrane 9 Homo sapiens 4-9 11741902-0 2002 ATP binding to the first nucleotide-binding domain of multidrug resistance protein MRP1 increases binding and hydrolysis of ATP and trapping of ADP at the second domain. Adenosine Diphosphate 144-147 ATP binding cassette subfamily C member 1 Homo sapiens 83-87 11801396-3 2002 Calculated [adenosine diphosphate] was 3-fold higher in mdx and 5-fold higher in utr-dys than in controls, consistent with an increased adenosine triphosphate requirement for ion pump activity. Adenosine Diphosphate 12-33 dystrophin, muscular dystrophy Mus musculus 56-59 11741902-12 2002 To assess whether ATP binding at NBD1 can enhance the trapping of ADP at NBD2, photoaffinity labeling experiments with [alpha-(32)P]8-N(3)ADP were performed and revealed that when presented with this compound labeling of MRP1 occurred at both NBDs. Adenosine Diphosphate 66-69 ATP binding cassette subfamily C member 1 Homo sapiens 221-225 12022947-3 2002 Among the various PTPC components, the adenine nucleotide translocator (ANT) appears to act as a bi-functional protein which, on the one hand, contributes to a crucial step of aerobic energy metabolism, the ADP/ATP translocation, and on the other hand, can be converted into a pro-apoptotic pore under the control of onco- and anti-oncoproteins from the Bax/Bcl-2 family. Adenosine Diphosphate 207-210 BCL2 apoptosis regulator Homo sapiens 358-363 12806027-5 2002 Whereas the P2Y12 receptor mediates the potentiation of dense granule release reaction, both the P2Y1 and P2Y12 receptors play an important role in the ADP-induced phospholipase A2 activation. Adenosine Diphosphate 152-155 phospholipase A2 group IB Homo sapiens 164-180 12022947-3 2002 Among the various PTPC components, the adenine nucleotide translocator (ANT) appears to act as a bi-functional protein which, on the one hand, contributes to a crucial step of aerobic energy metabolism, the ADP/ATP translocation, and on the other hand, can be converted into a pro-apoptotic pore under the control of onco- and anti-oncoproteins from the Bax/Bcl-2 family. Adenosine Diphosphate 207-210 BCL2 associated X, apoptosis regulator Homo sapiens 354-357 11846617-1 2002 Poly(ADP-ribose) polymerases (PARPs) are defined as cell signaling enzymes that catalyze the transfer of ADP-ribose units from NAD(+)to a number of acceptor proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 30-35 12454370-12 2002 A10-bound platelets could still be activated by ADP or thrombin suggesting that this human scFv may represent an original anti-platelet agent for the treatment of collagen-mediated thrombotic diseases. Adenosine Diphosphate 48-51 immunglobulin heavy chain variable region Homo sapiens 91-95 11991237-9 2002 When the prothrombinase assay was performed after addition of adenosine diphosphate (ADP) to the platelets, there was a significant increase in thrombin generation in the myeloproliferative disorder (MPD) group (3.1+/-2.0 micro/mL) compared to the thrombin generated by unstimulated myeloproliferative disorder platelets (2.07+/-1.69 micro/mL) (p=0.0006). Adenosine Diphosphate 62-83 coagulation factor II, thrombin Homo sapiens 12-20 11991237-9 2002 When the prothrombinase assay was performed after addition of adenosine diphosphate (ADP) to the platelets, there was a significant increase in thrombin generation in the myeloproliferative disorder (MPD) group (3.1+/-2.0 micro/mL) compared to the thrombin generated by unstimulated myeloproliferative disorder platelets (2.07+/-1.69 micro/mL) (p=0.0006). Adenosine Diphosphate 62-83 coagulation factor II, thrombin Homo sapiens 144-152 11991237-9 2002 When the prothrombinase assay was performed after addition of adenosine diphosphate (ADP) to the platelets, there was a significant increase in thrombin generation in the myeloproliferative disorder (MPD) group (3.1+/-2.0 micro/mL) compared to the thrombin generated by unstimulated myeloproliferative disorder platelets (2.07+/-1.69 micro/mL) (p=0.0006). Adenosine Diphosphate 85-88 coagulation factor II, thrombin Homo sapiens 12-20 11991237-9 2002 When the prothrombinase assay was performed after addition of adenosine diphosphate (ADP) to the platelets, there was a significant increase in thrombin generation in the myeloproliferative disorder (MPD) group (3.1+/-2.0 micro/mL) compared to the thrombin generated by unstimulated myeloproliferative disorder platelets (2.07+/-1.69 micro/mL) (p=0.0006). Adenosine Diphosphate 85-88 coagulation factor II, thrombin Homo sapiens 144-152 11991237-10 2002 An increase in thrombin generation was seen in the ADP-stimulated platelet samples in all ten paired samples studied. Adenosine Diphosphate 51-54 coagulation factor II, thrombin Homo sapiens 15-23 11991237-11 2002 Likewise, the addition of ADP to control platelets increased thrombin generation from 2.0+/-1.0 micro/mL in unstimulated platelets to 4.3+/-1.6 micro/mL in ADP-treated platelets (p=0.0006). Adenosine Diphosphate 26-29 coagulation factor II, thrombin Homo sapiens 61-69 11991237-12 2002 Thrombin generation increased in all of the ADP-stimulated platelet samples compared to the untreated platelets. Adenosine Diphosphate 44-47 coagulation factor II, thrombin Homo sapiens 0-8 11991237-17 2002 We have also shown that stimulation of platelets by addition of the agonist ADP results in enhanced PS expression, which appears increase the thrombogenic potential of the platelets as demonstrated by the enhanced thrombin generation demonstrated by these platelets in the prothrombinase assay. Adenosine Diphosphate 76-79 coagulation factor II, thrombin Homo sapiens 214-222 11853409-1 2002 Poly(ADP-ribose) polymerase-1 (PARP-1) is a chromatin-associated enzyme that is activated by DNA strand breaks and catalyzes the transfer of ADP-ribose groups from NAD to itself and other nuclear proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-37 12778954-0 2002 The minimum concentration of fibrinogen needed for platelet aggregation using ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 29-39 12210747-3 2002 We have reported that the formation and resorptive activity of rodent osteoclasts are stimulated powerfully by both extracellular ATP and its first degradation product, ADP, the latter acting at nanomolar concentrations, probably via the P2Y1 receptor subtype. Adenosine Diphosphate 169-172 purinergic receptor P2Y1 Rattus norvegicus 238-242 12658812-0 2002 Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy. Adenosine Diphosphate 92-95 major histocompatibility complex, class II, DR beta 1 Homo sapiens 24-32 12658812-2 2002 The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%, P < 0.05), the relative risk (RR) being 9.56. Adenosine Diphosphate 109-112 major histocompatibility complex, class II, DR beta 1 Homo sapiens 17-25 11804190-3 2001 The kinetic analyses of ATP hydrolysis by reconstituted purified Pgp suggest that ADP release is the rate-limiting step in the catalytic cycle and the substrates exert their effect by modulating ADP release. Adenosine Diphosphate 82-85 ATP binding cassette subfamily B member 1 Homo sapiens 65-68 11864710-5 2002 Adenosine decreased the response to ADP in a concentration-dependent way (analysis of variance, ANOVA: P<.0001): cAMP levels increased from 30.0 +/- 2.0 (control) to 46.0 +/- 3.0 pmol/10(9) platelets (in the presence of 15 mumol/l adenosine) and cGMP levels increased from 5.6 +/- 1.0 (control) to 10.9 +/- 2.0 pmol/10(9) platelets (in the presence of 15 mumol/l adenosine). Adenosine Diphosphate 36-39 cathelicidin antimicrobial peptide Homo sapiens 116-120 11726282-8 2001 The human GlcNAc 2-epimerase activity could not be detected in the absence of a nucleotide, whereas ATP, dATP, ddATP, ADP, and GTP enhanced the human GlcNAc 2-epimerase activity. Adenosine Diphosphate 118-121 renin binding protein Homo sapiens 10-28 11726282-8 2001 The human GlcNAc 2-epimerase activity could not be detected in the absence of a nucleotide, whereas ATP, dATP, ddATP, ADP, and GTP enhanced the human GlcNAc 2-epimerase activity. Adenosine Diphosphate 118-121 renin binding protein Homo sapiens 150-168 11739463-6 2001 We found a significant correlation between PRL values and ADP stimulation of platelets in pregnant women (r = 0.56; P < 0.0001) and patients with pituitary tumors (r = 0.57; P = 0.006). Adenosine Diphosphate 58-61 prolactin Homo sapiens 43-46 11739745-13 2002 These findings establish tankyrase 2 as a bona fide PARP, with itself and TRF1 as acceptors of ADP-ribosylation, and suggest the possibility of a role for tankyrase 2 at telomeres. Adenosine Diphosphate 95-98 telomeric repeat binding factor 1 Homo sapiens 74-78 12841327-5 2002 Fe2+/ADP and 2,2,-azobis-(2-amidinopropane) dihydrochloride (AAPH) induced swelling of mitochondria and the release of Ca2+ and Cyt.c were not coupled with depolarization or CsA-sensitivity while dibucaine-induced swelling occurred without depolarization, Cyt.c-release or by a CsA-sensitive mechanism. Adenosine Diphosphate 5-8 cytochrome c, somatic Homo sapiens 128-133 12841327-5 2002 Fe2+/ADP and 2,2,-azobis-(2-amidinopropane) dihydrochloride (AAPH) induced swelling of mitochondria and the release of Ca2+ and Cyt.c were not coupled with depolarization or CsA-sensitivity while dibucaine-induced swelling occurred without depolarization, Cyt.c-release or by a CsA-sensitive mechanism. Adenosine Diphosphate 5-8 cytochrome c, somatic Homo sapiens 256-261 12696575-0 2002 ADP activation induces bFGF binding to platelets in vitro. Adenosine Diphosphate 0-3 fibroblast growth factor 2 Homo sapiens 23-27 12696575-5 2002 Platelet activation by ADP induces bFGF binding to platelets. Adenosine Diphosphate 23-26 fibroblast growth factor 2 Homo sapiens 35-39 12152879-3 2001 Specific inhibitors of mitochondrial channels ADP and cyclosporine A prevented beta-amyloid peptide-induced swelling of mitochondria. Adenosine Diphosphate 46-49 amyloid beta precursor protein Homo sapiens 79-99 11804190-3 2001 The kinetic analyses of ATP hydrolysis by reconstituted purified Pgp suggest that ADP release is the rate-limiting step in the catalytic cycle and the substrates exert their effect by modulating ADP release. Adenosine Diphosphate 195-198 ATP binding cassette subfamily B member 1 Homo sapiens 65-68 11738079-11 2001 In contrast, addition of CT 8 min after the addition of ADP results only in about 50% reversal of platelet aggregation. Adenosine Diphosphate 56-59 leucine zipper protein 4 Homo sapiens 25-29 11672752-9 2001 Insulin (30 or 300 microU/ml) also enhanced ADP-induced platelet aggregation in PRP (P<.01 or P<.001; n=14). Adenosine Diphosphate 44-47 insulin Homo sapiens 0-7 11705828-7 2001 ADP- and U46619-induced ex vivo platelet aggregation and platelet P-selectin expression were augmented during CFVs. Adenosine Diphosphate 0-3 selectin P Canis lupus familiaris 66-76 11546776-7 2001 In the same cells, ADP and 2MeSADP also stimulated the phosphorylation of Erk1 and Erk2, in a pertussis toxin-sensitive way. Adenosine Diphosphate 19-22 mitogen-activated protein kinase 3 Homo sapiens 74-78 11546776-7 2001 In the same cells, ADP and 2MeSADP also stimulated the phosphorylation of Erk1 and Erk2, in a pertussis toxin-sensitive way. Adenosine Diphosphate 19-22 mitogen-activated protein kinase 1 Homo sapiens 83-87 11595666-0 2001 Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio. Adenosine Diphosphate 96-99 insulin Homo sapiens 57-64 11722114-4 2001 The selective targeting of PAR1 enables aprotinin to protect platelets from unwanted activation by thrombin generated during CPB surgery (consistent with a role in platelet-preservation), while permitting the participation of platelets in the formation of hemostatic plugs at wound and suture sites, where collagen, ADP, and epinephrine are most likely to be expressed. Adenosine Diphosphate 316-319 coagulation factor II thrombin receptor Homo sapiens 27-31 11672752-9 2001 Insulin (30 or 300 microU/ml) also enhanced ADP-induced platelet aggregation in PRP (P<.01 or P<.001; n=14). Adenosine Diphosphate 44-47 prion protein Homo sapiens 80-83 11697744-10 2001 Thiopental appears to enhance ADP- and epinephrine-induced secondary platelet aggregation by increasing AA release during primary aggregation, possibly by the activation of phospholipase A2. Adenosine Diphosphate 30-33 phospholipase A2 group IB Homo sapiens 173-189 11580247-11 2001 ATP, AMP-PNP, and ADP bound forms of FliI within the FliH/FliI complex regained sensitivity to clostripain cleavage. Adenosine Diphosphate 18-21 FLII actin remodeling protein Homo sapiens 37-41 11580247-11 2001 ATP, AMP-PNP, and ADP bound forms of FliI within the FliH/FliI complex regained sensitivity to clostripain cleavage. Adenosine Diphosphate 18-21 FLII actin remodeling protein Homo sapiens 58-62 11580247-12 2001 Also, the sensitivity of the two FliI(CL38) cleavage sites was much greater in the ATP and AMP-PNP bound forms than in either the ADP bound form or nucleotide-free FliI. Adenosine Diphosphate 130-133 FLII actin remodeling protein Homo sapiens 33-37 11606309-6 2001 An adenosine diphosphate (ADP) scavenger, apyrase, inhibited the platelet aggregation induced by thrombin, but not the release of endostatin. Adenosine Diphosphate 3-24 coagulation factor II Rattus norvegicus 97-105 11606309-6 2001 An adenosine diphosphate (ADP) scavenger, apyrase, inhibited the platelet aggregation induced by thrombin, but not the release of endostatin. Adenosine Diphosphate 26-29 coagulation factor II Rattus norvegicus 97-105 11606309-8 2001 We conclude that thrombin-induced endostatin release from rat platelets is PAR4-mediated via an ADP-independent mechanism that can occur independently of platelet aggregation. Adenosine Diphosphate 96-99 coagulation factor II Rattus norvegicus 17-25 11769462-5 2001 Although these responses were known to occur, via P2X7, we have recently found that ATP and ADP induced the formation of membrane ruffles and chemotaxis through Gi/o-coupled P2Y receptors. Adenosine Diphosphate 92-95 purinergic receptor P2X 7 Homo sapiens 50-54 11390380-8 2001 Finally, introducing the portion of filamin-A interacting with the CaR into CaR-transfected HEK-293 cells using protein transduction with a His-tagged, Tat-filamin-A fusion protein nearly abolished CaR-mediated activation of ERK1/2 MAPK but had no effect on ERK1/2 activity stimulated by ADP. Adenosine Diphosphate 288-291 filamin A Homo sapiens 36-45 11532960-2 2001 We report the structure of the C-terminal ABC ATPase domain of TAP1 (cTAP1) bound to ADP. Adenosine Diphosphate 85-88 transporter 1, ATP binding cassette subfamily B member Homo sapiens 63-67 11520817-0 2001 Differential inhibition of adenosine diphosphate- versus thrombin receptor-activating peptide-stimulated platelet fibrinogen binding by abciximab due to different glycoprotein IIb/IIIa activation kinetics. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 114-124 11520817-3 2001 ADP-induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50%. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 11520817-4 2001 Interestingly, striking differences in fibrinogen binding kinetics in ADP- versus TRAP-stimulated platelets were observed. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 39-49 11520817-5 2001 ADP-induced fibrinogen binding was much slower than that of abciximab. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 11502873-2 2001 ADP-induced platelet aggregation is mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y(1), and Gi-linked P2T(AC), which has not been cloned. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Rattus norvegicus 104-110 11502873-6 2001 2MeSADP (EC(50) = 1.3 nM) and ADP (EC(50) = 18 nM) also induced intracellular calcium mobilization in P2Y(1)-expressing cells. Adenosine Diphosphate 4-7 purinergic receptor P2Y1 Rattus norvegicus 102-108 11563916-0 2001 Nucleotide-induced transition of GroEL from the high-affinity to the low-affinity state for a target protein: effects of ATP and ADP on the GroEL-affected refolding of alpha-lactalbumin. Adenosine Diphosphate 129-132 lactalbumin alpha Homo sapiens 168-185 11563916-1 2001 We studied the refolding kinetics of alpha-lactalbumin in the presence of wild-type GroEL and its ATPase-deficient mutant D398A at various concentrations of nucleotides (ATP and ADP). Adenosine Diphosphate 178-181 lactalbumin alpha Homo sapiens 37-54 11451943-1 2001 P-glycoprotein (Pgp), the ATP-binding cassette multidrug transporter, exhibits a drug (substrate)-stimulatable ATPase activity, and vanadate (Vi) inhibits this activity by stably trapping the nucleoside diphosphate in the Pgp.ADP.Vi conformation. Adenosine Diphosphate 226-229 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 11451943-1 2001 P-glycoprotein (Pgp), the ATP-binding cassette multidrug transporter, exhibits a drug (substrate)-stimulatable ATPase activity, and vanadate (Vi) inhibits this activity by stably trapping the nucleoside diphosphate in the Pgp.ADP.Vi conformation. Adenosine Diphosphate 226-229 ATP binding cassette subfamily B member 1 Homo sapiens 16-19 11451943-7 2001 Our results demonstrate that during the catalytic cycle of Pgp, although the transition state, Pgp x ADP x P(i) (Vi), can be generated both via the hydrolysis of ATP or by directly providing ADP to the system, in the presence of substrate the reaction is driven in the forward direction, i.e. hydrolysis of ATP. Adenosine Diphosphate 101-104 ATP binding cassette subfamily B member 1 Homo sapiens 59-62 11451943-7 2001 Our results demonstrate that during the catalytic cycle of Pgp, although the transition state, Pgp x ADP x P(i) (Vi), can be generated both via the hydrolysis of ATP or by directly providing ADP to the system, in the presence of substrate the reaction is driven in the forward direction, i.e. hydrolysis of ATP. Adenosine Diphosphate 101-104 ATP binding cassette subfamily B member 1 Homo sapiens 95-98 11749837-5 2001 TSA was also shown to decrease the P-selectin expression on platelet surface induced by thrombin in washed platelet and by adenosine diphosphate (ADP) 5 micromol/L in whole blood. Adenosine Diphosphate 123-144 selectin P Rattus norvegicus 35-45 11500375-4 2001 In vitro binding assays showed that the association of FANCC and Hsp70 involves the ATPase domain of Hsp70 and the central 320 residues of FANCC, and that both Hsp40 and ATP/ADP are required. Adenosine Diphosphate 174-177 FA complementation group C Homo sapiens 55-60 11493449-6 2001 Responses to adenosine diphosphate, arachidonic acid, and the thromboxane analog U46619 were normal but were enhanced to low thrombin concentrations. Adenosine Diphosphate 13-34 coagulation factor II, thrombin Homo sapiens 125-133 11470053-6 2001 With P-31 MRS, biochemical defects are quantitated, including low levels of ATP and phosphocreatine (PCr) and elevated concentrations of ADP and inorganic phosphate (Pi), which may all be related to weakness and fatigue. Adenosine Diphosphate 137-140 ATPase H+ transporting V1 subunit E1 Homo sapiens 5-9 11483513-0 2001 Functional reconstitution of the import of the yeast ADP/ATP carrier mediated by the TIM10 complex. Adenosine Diphosphate 53-56 protein transporter TIM10 Saccharomyces cerevisiae S288C 85-90 11483513-1 2001 Import of the ADP/ATP carrier (AAC) into mitochondria requires the soluble TIM10 complex to cross the intermembrane space. Adenosine Diphosphate 14-17 protein transporter TIM10 Saccharomyces cerevisiae S288C 75-80 11515379-6 2001 The concentrations of azide, AMP, Pi, fluoride, and ADP, which inhibit the ATPase activity by 50% (IC50), were found to be approximately 100, 0.25, 0.125, 0.04, and 0.035 mM, respectively. Adenosine Diphosphate 52-55 ATPase GET3-like Solanum tuberosum 75-81 11444977-8 2001 MRP1 expressed in P. pastoris binds 8-azido[alpha-(32)P]ATP in a Mg(2+)-dependent and EDTA-sensitive fashion, which can be competed by a molar excess of ADP and ATP. Adenosine Diphosphate 153-156 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 11681712-5 2001 Pretreatment of eEF2 with GDP or ADP-ribosylation of eEF2 by diphtheria toxin can obviously reduce the ability of eEF2 to form the complex with the synthetic oligoribonucleotide. Adenosine Diphosphate 33-36 eukaryotic translation elongation factor 2 Rattus norvegicus 16-20 11447076-7 2001 Higher fibrinogen levels were associated with increased epinephrine-induced aggregation (P=0.002) and a trend for ADP-induced aggregation (P=0.07). Adenosine Diphosphate 114-117 fibrinogen beta chain Homo sapiens 7-17 11447076-8 2001 The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P>0.90). Adenosine Diphosphate 205-208 fibrinogen beta chain Homo sapiens 4-14 11505083-5 2001 Significant decreases in levels of PDGF, sP-selectin and TGF-beta1 released from platelets in response to 5 micromol/l ADP and 1 microg/ml collagen after taking of sarpogrelate were found. Adenosine Diphosphate 119-122 transforming growth factor beta 1 Homo sapiens 57-66 11681712-5 2001 Pretreatment of eEF2 with GDP or ADP-ribosylation of eEF2 by diphtheria toxin can obviously reduce the ability of eEF2 to form the complex with the synthetic oligoribonucleotide. Adenosine Diphosphate 33-36 eukaryotic translation elongation factor 2 Rattus norvegicus 53-57 11681712-5 2001 Pretreatment of eEF2 with GDP or ADP-ribosylation of eEF2 by diphtheria toxin can obviously reduce the ability of eEF2 to form the complex with the synthetic oligoribonucleotide. Adenosine Diphosphate 33-36 eukaryotic translation elongation factor 2 Rattus norvegicus 53-57 11422017-6 2001 Reduced fibrinogen binding also led to a significant reduction of the aggregation response to ADP (down to 37% +/- 20) and collagen (down to 0%). Adenosine Diphosphate 94-97 fibrinogen beta chain Homo sapiens 8-18 11334790-8 2001 Compared to control, the direct ADP transfer was increased in MDX ventricles. Adenosine Diphosphate 32-35 dystrophin, muscular dystrophy Mus musculus 62-65 11259441-6 2001 Consistent with these findings, when ADP-induced oxidative phosphorylation is limited by exogenous beta-NADH, recombinant Bcl-x(L) can sustain outer mitochondrial membrane permeability to ADP. Adenosine Diphosphate 37-40 BCL2 like 1 Homo sapiens 122-130 11440368-8 2001 MgADP potentiated the inhibitory effect of repaglinide on Kir6.2/SUR1 and (to a lesser extent) Kir6.2/SUR2B, but not on Kir6.2/SUR2A. Adenosine Diphosphate 0-5 ATP-binding cassette sub-family C member 8 Xenopus laevis 65-69 11259441-6 2001 Consistent with these findings, when ADP-induced oxidative phosphorylation is limited by exogenous beta-NADH, recombinant Bcl-x(L) can sustain outer mitochondrial membrane permeability to ADP. Adenosine Diphosphate 188-191 BCL2 like 1 Homo sapiens 122-130 11434688-10 2001 To document the ability of t-PA to be stored in a rapidly-releasable form in these cells, we isolated platelet-like particles from the supernatant of differentiated cells and determined that particles from Ad/t-PA-infected cells display a 4-8 fold enhanced secretion of t-PA following treatment with the clasical secretagogue calcium ionphore 23187, ADP, or thrombin. Adenosine Diphosphate 350-353 plasminogen activator, tissue type Homo sapiens 209-213 11828469-5 2001 The hypothesis is based on the allosteric ATP inhibition of cytochrome c oxidase at high intramitochondrial ATP/ADP ratios ("second mechanism of respiratory control"), which is switched on by cAMP-dependent phosphorylation and switched off by calcium-induced dephosphorylation of the enzyme. Adenosine Diphosphate 112-115 cytochrome c, somatic Homo sapiens 60-72 11434688-10 2001 To document the ability of t-PA to be stored in a rapidly-releasable form in these cells, we isolated platelet-like particles from the supernatant of differentiated cells and determined that particles from Ad/t-PA-infected cells display a 4-8 fold enhanced secretion of t-PA following treatment with the clasical secretagogue calcium ionphore 23187, ADP, or thrombin. Adenosine Diphosphate 350-353 plasminogen activator, tissue type Homo sapiens 209-213 11245789-13 2001 RaM in heart is strongly inhibited by AMP and has a biphasic response to ADP; it is activated at low concentrations and inhibited at high concentrations. Adenosine Diphosphate 73-76 CCDC26 long non-coding RNA Homo sapiens 0-3 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. Adenosine Diphosphate 130-151 fibrinogen beta chain Homo sapiens 7-17 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. Adenosine Diphosphate 153-156 fibrinogen beta chain Homo sapiens 7-17 11313254-2 2001 Adding fibrinogen to washed platelet suspensions inhibited increases in cytosolic [Ca(++)] concentrations ([Ca(++)](i)) evoked by adenosine diphosphate (ADP) and thrombin in a concentration-dependent manner in the presence of external Ca(++) but not in the absence of external Ca(++) or in the presence of the nonselective cation channel blocker SKF96365, indicating selective inhibition of Ca(++) entry. Adenosine Diphosphate 153-156 coagulation factor II, thrombin Homo sapiens 162-170 11313254-7 2001 Fibrinogen inhibited actin polymerization evoked by ADP or thapsigargin in control cells and in cells loaded with the Ca(++) chelator dimethyl BAPTA. Adenosine Diphosphate 52-55 fibrinogen beta chain Homo sapiens 0-10 11352081-5 2001 RESULTS: Both dosages of tirofiban and abciximab reduced fibrinogen binding in response to 0.2 microM ADP comparably. Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 57-67 11352081-6 2001 However, fibrinogen binding in response to 1.0 microM ADP or 25 microM TRAP was inhibited to a greater extent by the RESTORE dosage of tirofiban and abciximab than by the PRISM-PLUS dosage of tirofiban (P< 0.05). Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 9-19 11336199-4 2001 However, exposure to ADP (10 micromol/L) produced a biphasic increase in Ca(i) that was markedly decreased in cells from LPS-treated animals (P < 0.0001). Adenosine Diphosphate 21-24 protein disulfide isomerase associated 4 Mus musculus 73-78 11336199-5 2001 Peak ADP-stimulated Ca(i) responses averaged 2.2 +/- 0.21 in CON cells and 1.5 +/- 0.11 (P < 0.01) in cells dispersed from LPS-treated animals. Adenosine Diphosphate 5-8 protein disulfide isomerase associated 4 Mus musculus 20-25 11336199-8 2001 In the absence of extracellular Ca2+ (plus 10 micromol/L EGTA), exposure to ADP (10 micromol/L) produced transient increases in Ca(i) (Ca2+ release) that were decreased in cells from LPS-treated versus CON animals. Adenosine Diphosphate 76-79 protein disulfide isomerase associated 4 Mus musculus 128-133 11305905-13 2001 Furthermore, S-nitrosylated tTG inhibited platelet aggregation induced by ADP. Adenosine Diphosphate 74-77 transglutaminase 2 Homo sapiens 28-31 11401530-2 2001 We report that autophosphorylated CaM-kinase II dephosphorylates itself in the presence of ADP (termed autodephosphorylation). Adenosine Diphosphate 91-94 calmodulin 3 Homo sapiens 34-37 11401530-4 2001 (32)P-ATP was produced when ADP was added to (32)P-labeled CaM-kinase II, indicating that the enzyme was undergoing dephosphorylation through a reversal of the autophosphorylation reaction. Adenosine Diphosphate 28-31 calmodulin 3 Homo sapiens 59-62 11102441-6 2001 Pro-caspase-8 and cytochrome c were released from isolated mitochondria that were treated with an inhibitor of the ADP/ATP carrier atractyloside, which opens the mitochondria permeability transition pore. Adenosine Diphosphate 115-118 cytochrome c, somatic Homo sapiens 18-30 11325638-6 2001 The discovery of the role of ADP as the principle of platelet aggregation stimuli was rapidly followed by other important discoveries such as the aggregating properties of collagen and thrombin, the release reaction, the metabolism of arachidonic acid, and the inhibitory effect of aspirin. Adenosine Diphosphate 29-32 coagulation factor II, thrombin Homo sapiens 185-193 11121420-0 2001 Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in Human P-glycoprotein. Adenosine Diphosphate 69-72 ATP binding cassette subfamily B member 1 Homo sapiens 91-105 11121420-14 2001 We suggest that substrates modulate the rate of ATPase activity of Pgp by controlling the rate of dissociation of ADP following ATP hydrolysis and that ADP release is the rate-limiting step in the normal catalytic cycle of Pgp. Adenosine Diphosphate 114-117 ATP binding cassette subfamily B member 1 Homo sapiens 67-70 11121420-14 2001 We suggest that substrates modulate the rate of ATPase activity of Pgp by controlling the rate of dissociation of ADP following ATP hydrolysis and that ADP release is the rate-limiting step in the normal catalytic cycle of Pgp. Adenosine Diphosphate 114-117 ATP binding cassette subfamily B member 1 Homo sapiens 223-226 11121420-14 2001 We suggest that substrates modulate the rate of ATPase activity of Pgp by controlling the rate of dissociation of ADP following ATP hydrolysis and that ADP release is the rate-limiting step in the normal catalytic cycle of Pgp. Adenosine Diphosphate 152-155 ATP binding cassette subfamily B member 1 Homo sapiens 67-70 11121420-14 2001 We suggest that substrates modulate the rate of ATPase activity of Pgp by controlling the rate of dissociation of ADP following ATP hydrolysis and that ADP release is the rate-limiting step in the normal catalytic cycle of Pgp. Adenosine Diphosphate 152-155 ATP binding cassette subfamily B member 1 Homo sapiens 223-226 11053408-8 2001 Moreover in isolated cell membranes, Epo treatment inhibited ADP-ribosylation of Gi and increased the binding of GTP. Adenosine Diphosphate 61-64 erythropoietin Homo sapiens 37-40 11170469-4 2001 The vanadate.ADP.Mg(2+) complex was trapped in one catalytic site of membrane-bound or highly purified P-glycoprotein, and the other site was labeled with MIANS [2-(4"-maleimidylanilino)naphthalene-6-sulfonic acid]. Adenosine Diphosphate 13-16 ATP binding cassette subfamily B member 1 Homo sapiens 103-117 11248084-1 2001 Poly(ADP-ribose) polymerase-1 (PARP-1; EC ) is an abundant nuclear enzyme, activated by DNA strand breaks to attach up to 200 ADP-ribose groups to nuclear proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-37 11297035-9 2001 ADP (30 microM)-induced CD40L expression was not inhibited by aspirin. Adenosine Diphosphate 0-3 CD40 ligand Homo sapiens 24-29 11297035-10 2001 In contrast, clopidogrel treatment completely abolished ADP-induced expression of CD40L. Adenosine Diphosphate 56-59 CD40 ligand Homo sapiens 82-87 11307824-6 2001 Finally, we provide evidence that secreted ADP, known to play a key role in TRAP-induced irreversible phase of aggregation, was involved in the sustained MLC phosphorylation through Rho-kinase and could be replaced by epinephrine. Adenosine Diphosphate 43-46 modulator of VRAC current 1 Homo sapiens 154-157 11246553-6 2001 In blood from subjects given aspirin for 5 days, abciximab-induced inhibition of the capacity to bind fibrinogen in response to 1 microM ADP was greater when the daily dose had been 325 mg compared with 81 mg (% inhibition: no aspirin 53 +/- 6; 81 mg daily 62 +/- 5; 325 mg daily 69 +/- 6). Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 102-112 11170435-0 2001 Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes. Adenosine Diphosphate 78-81 nuclear receptor subfamily 3 group C member 1 Homo sapiens 115-138 11170435-10 2001 This suggests that GR-bound hsp70 is also converted from the ATP-dependent to the ADP-dependent conformation while it cooperates with hsp90 to activate steroid binding activity. Adenosine Diphosphate 82-85 nuclear receptor subfamily 3 group C member 1 Homo sapiens 19-21 11044447-0 2001 Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice. Adenosine Diphosphate 38-41 voltage-dependent anion channel 1 Mus musculus 128-133 11044447-3 2001 To test the hypothesis that VDAC1 constitutes a pathway for ADP translocation into mitochondria, the apparent mitochondrial sensitivity for ADP (Km(ADP)) and the calculated rate of respiration in the presence of the maximal ADP concentration (Vmax) have been assessed using skinned fibers prepared from two oxidative muscles (ventricle and soleus) and a glycolytic muscle (gastrocnemius) in control and vdac1(-/-) mice. Adenosine Diphosphate 60-63 voltage-dependent anion channel 1 Mus musculus 28-33 11121265-5 2001 HK activity was obtained by measuring ATP and ADP amounts with HPLC. Adenosine Diphosphate 46-49 hexokinase 1 Homo sapiens 0-2 11257802-5 2001 This RGD-proinsulin showed an inhibitory activity of adenosine 5"-diphosphate-induced human platelet aggregation with an IC50 value of 200 nM. Adenosine Diphosphate 53-77 insulin Homo sapiens 9-19 11708401-8 2001 Increases in muscle tissue CK-B content can be energetically favourable because of its lower Michaelis constant (Km) for ADP. Adenosine Diphosphate 121-124 creatine kinase B Homo sapiens 27-31 11190901-7 2001 Incubation with adenosine diphosphate in the control group resulted in minor increases of platelet activation, which was significant only for platelet-bound fibrinogen (16.6 +/- 11.3 vs. 42.5 +/- 22.1; p = 0.02). Adenosine Diphosphate 16-37 fibrinogen beta chain Homo sapiens 157-167 11016934-2 2000 PARP-1, the best understood and until recently the only known member of this family, is a DNA damage signal protein catalyzing its automodification with multiple, variably sized ADP-ribose polymers that may contain up to 200 residues and several branching points. Adenosine Diphosphate 178-182 poly(ADP-ribose) polymerase 1 Homo sapiens 0-6 11101309-7 2000 P-glycoprotein fluorescence was highly quenched on binding of fluorescent nucleotides, and moderately quenched by ATP, ADP, and AMP-PNP, suggesting that the site for nucleotide binding is located relatively close to tryptophan residues. Adenosine Diphosphate 119-122 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 10993895-10 2000 We suggest that the lower expression of the mutant channel and the reduced affinity of NBF2 for MgADP may lead to a smaller K(ATP)(+) current in R1420C-PHHI beta-cells and thereby to the enhanced insulin secretion. Adenosine Diphosphate 96-101 insulin Homo sapiens 196-203 11150578-4 2000 Platelet aggregation induced by 1 and 10 microM ADP was significantly higher in patients with elevated CRP levels than those with normal CRP levels (P<0.05). Adenosine Diphosphate 48-51 C-reactive protein Homo sapiens 103-106 11177446-6 2000 PRP was treated with 10 microM CyH or vehicle, then activated by ADP. Adenosine Diphosphate 65-68 complement component 4 binding protein alpha Homo sapiens 0-3 11150578-4 2000 Platelet aggregation induced by 1 and 10 microM ADP was significantly higher in patients with elevated CRP levels than those with normal CRP levels (P<0.05). Adenosine Diphosphate 48-51 C-reactive protein Homo sapiens 137-140 11063593-4 2000 To further characterize these sites, eEF-2 was incubated in the presence of N-methylanthraniloyl (Mant) fluorescent derivatives of GTP, GDP, ATP, and ADP. Adenosine Diphosphate 150-153 eukaryotic translation elongation factor 2 Rattus norvegicus 37-42 11086166-2 2000 Furthermore, the potentiating effect of adrenaline on thrombin-induced PtdIns(3, 4)P(2) production was independent on secreted ADP, whereas, the effect of adrenaline on SFRLLN-induced PtdIns(3,4)P(2) production was completely dependent of secreted ADP. Adenosine Diphosphate 127-130 coagulation factor II, thrombin Homo sapiens 54-62 11086166-2 2000 Furthermore, the potentiating effect of adrenaline on thrombin-induced PtdIns(3, 4)P(2) production was independent on secreted ADP, whereas, the effect of adrenaline on SFRLLN-induced PtdIns(3,4)P(2) production was completely dependent of secreted ADP. Adenosine Diphosphate 248-251 coagulation factor II, thrombin Homo sapiens 54-62 11086166-4 2000 It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN. Adenosine Diphosphate 53-56 coagulation factor II, thrombin Homo sapiens 101-109 11009602-4 2000 Vanadate trapping of Mg.ADP caused a reversible decrease in the binding capacity of the transported substrate [(3)H]-vinblastine and the nontransported modulator [(3)H]XR9576 to P-gp in CH(r)B30 cell membranes. Adenosine Diphosphate 24-27 ATP binding cassette subfamily B member 1 Homo sapiens 178-182 11073862-4 2000 Therefore, the interaction of ADP with the full complement of its receptors seems to be essential for normal platelet secretion, and PSD patients may be heterozygotes for the congenital severe defect of P2(CYC). Adenosine Diphosphate 30-33 cytochrome c, somatic Homo sapiens 203-210 11078372-7 2000 Platelet aggregation was monitored ex vivo as a change in light transmission through PRP following the injection of ADP (5 microM). Adenosine Diphosphate 116-119 proline rich protein HaeIII subfamily 1 Mus musculus 85-88 11108903-9 2000 Compared to platelet fibrinogen binding of unfixed resting (4.5+/-2.1%) and ADP-stimulated (56.7+/-22.6%) samples, formaldehyde or paraformaldehyde fixation had no significant influence on resting samples, but mildly increased fibrinogen binding in stimulated samples. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 21-31 11011027-8 2000 Adenosine 5"-diphosphate (ADP)-induced platelet aggregation was inhibited with S-nitroso-N-acetylpenicillamine, SIN-1 and nitroglycerine. Adenosine Diphosphate 0-24 MAPK associated protein 1 Homo sapiens 112-117 11011027-8 2000 Adenosine 5"-diphosphate (ADP)-induced platelet aggregation was inhibited with S-nitroso-N-acetylpenicillamine, SIN-1 and nitroglycerine. Adenosine Diphosphate 26-29 MAPK associated protein 1 Homo sapiens 112-117 10956268-7 2000 We demonstrated an increase of type IIa MyHC protein content in the soleus from approximately 0.5% in controls to approximately 18% after clenbuterol treatment (P < 0.05), which was accompanied by an increase in the total adenine nucleotide pool (TAN; approximately 19%, P < 0.05) and energy charge [E-C = (ATP + 0.5 ADP)/(ATP + ADP + AMP); approximately 4%; P < 0.05]. Adenosine Diphosphate 323-326 myosin heavy chain 13 Rattus norvegicus 40-44 11011142-1 2000 Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation. Adenosine Diphosphate 89-92 ADP-ribosyltransferase 2b Rattus norvegicus 6-11 11011142-1 2000 Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation. Adenosine Diphosphate 89-92 ADP-ribosyltransferase 2b Rattus norvegicus 6-9 11011142-1 2000 Mouse Rt6.1 and Rt6.2, homologues of rat T-cell RT6 antigens, catalyze arginine-specific ADP-ribosylation. Adenosine Diphosphate 89-92 ADP-ribosyltransferase 2b Rattus norvegicus 48-51 11107928-2 2000 The normal regulation of insulin secretion is linked to glucose metabolism in the pancreatic beta-cell, a major but not exclusive signal for secretion being closure of K+ ATP-dependent channels in the cell membrane through an increase in the cytosolic ATP/ADP. Adenosine Diphosphate 256-259 insulin Homo sapiens 25-32 10979958-4 2000 The aim of the present study was to determine whether externally added ADP could still act through the Gi pathway in Galphaq-deficient mouse platelets and thereby amplify the residual responses to agonists such as thrombin or collagen. Adenosine Diphosphate 71-74 coagulation factor II Mus musculus 214-222 10956268-7 2000 We demonstrated an increase of type IIa MyHC protein content in the soleus from approximately 0.5% in controls to approximately 18% after clenbuterol treatment (P < 0.05), which was accompanied by an increase in the total adenine nucleotide pool (TAN; approximately 19%, P < 0.05) and energy charge [E-C = (ATP + 0.5 ADP)/(ATP + ADP + AMP); approximately 4%; P < 0.05]. Adenosine Diphosphate 335-338 myosin heavy chain 13 Rattus norvegicus 40-44 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 63-84 fibrinogen beta chain Homo sapiens 24-34 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 24-34 10933796-9 2000 Studies carried out with pre-phosphorylated recombinant HER-2 proteins suggest that while autophosphorylation is not a prerequisite for enzymatic activity, this protein modification actually directly affects the catalytic mechanism by enhancing the rate of ADP release and that of the rate-limiting step. Adenosine Diphosphate 257-260 erb-b2 receptor tyrosine kinase 2 Homo sapiens 56-61 10823818-10 2000 Kinetic analysis also indicates that, although both products of the kinase reaction, ADP and a phosphorylated IkappaBalpha peptide, exhibited competitive inhibitory kinetics, only ADP with the low K(i) of 0.77 micrometer may play a physiological role in regulation of the enzyme activity. Adenosine Diphosphate 180-183 NFKB inhibitor alpha Homo sapiens 110-122 11185961-2 2000 The [32P]ADP-ribose polymers synthesized were chemically detached from PARP by alkaline hydrolysis of the monoester bond between the carboxylate moiety of Glu and the polymer. Adenosine Diphosphate 9-12 poly(ADP-ribose) polymerase 1 Homo sapiens 71-75 11185961-9 2000 Therefore, we conclude that high concentrations of PARP lead to acceptor substrate inhibition at the level of the ADP-ribose chain initiation reaction. Adenosine Diphosphate 114-117 poly(ADP-ribose) polymerase 1 Homo sapiens 51-55 11030461-5 2000 NAF also inhibited (P <0.0001) shape change (PSC; an early phase of platelet activation, characterised by an increase in MPV) induced by ET-1 (0.4 micromol/l) in combination with ADP (0.05-0.15 micromol/l) or serotonin (0.03-0.13 micromol/ l). Adenosine Diphosphate 182-185 C-X-C motif chemokine ligand 8 Homo sapiens 0-3 10966860-2 2000 Glucose metabolism generates oscillations in the ATP/ADP ratio which lead to opening and closing of ATP-sensitive K(+)-channels producing subsequent oscillations in membrane potential, cytoplasmic calcium and insulin release. Adenosine Diphosphate 53-56 insulin Homo sapiens 209-216 10896818-14 2000 Total adenine nucleotides (ATP, ADP, and AMP) were significantly elevated 90 min postresuscitation in the insulin group. Adenosine Diphosphate 32-35 insulin Homo sapiens 106-113 10896818-18 2000 Total nucleotide pool levels were not different between groups, indicating that there was a shift of the equilibrium away from the metabolites toward ATP and ADP in the insulin-treated group. Adenosine Diphosphate 158-161 insulin Homo sapiens 169-176 11030463-7 2000 We conclude that ADP-induced shape change occurs via the P2Y1 receptor, which can be differentially coupled to Rho-kinase and Ca2+-linked pathways dependent on the method of platelet preparation. Adenosine Diphosphate 17-20 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 111-121 11030463-2 2000 In this study we show that the Ca2+ chelator BAPTA and the Rho-kinase inhibitor Y-27632 inhibit ADP-induced myosin light chain (MLC) phosphorylation and platelet shape change through distinct pathways and with distinct kinetics. Adenosine Diphosphate 96-99 Rho-associated coiled-coil containing protein kinase 2 Mus musculus 59-69 10896718-9 2000 The order of purinoceptor agonist potency for [Ca2+]i increases was ATP = UTP > 2-MeSATP > ADP >> adenosine, consistent with the profile for P2Y2 purinoceptors. Adenosine Diphosphate 97-100 carbonic anhydrase 2 Rattus norvegicus 47-50 10873456-11 2000 The domain that has been shown to bind ADP in E. coli SCS is more open in the pig heart, GTP-specific SCS structure. Adenosine Diphosphate 39-42 succinate-CoA ligase ADP-forming subunit beta Sus scrofa 54-57 10884507-2 2000 TA-993 and MB3 concentration-dependently inhibited fibrinogen binding to the ADP-stimulated platelets as well as inhibiting platelet aggregation. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 51-61 10884507-4 2000 Aggregation of ADP-treated fixed platelets caused by the addition of fibrinogen was inhibited by RGDS but not by TA-993 and MB3. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 69-79 10946088-4 2000 TPO but not G-CSF synergized with threshold ADP concentrations to induce maximal aggregation and ATP release. Adenosine Diphosphate 44-47 thrombopoietin Homo sapiens 0-3 10904037-3 2000 We postulated that the physiological changes associated with muscle contraction (i.e., increases in calcium and ADP concentration) stimulate mitochondrial generation of ROS by a phospholipase A(2) (PLA(2))-modulated process and that sepsis enhances muscle generation of ROS by upregulating PLA(2) activity. Adenosine Diphosphate 112-115 phospholipase A2 group IB Homo sapiens 178-196 10904037-3 2000 We postulated that the physiological changes associated with muscle contraction (i.e., increases in calcium and ADP concentration) stimulate mitochondrial generation of ROS by a phospholipase A(2) (PLA(2))-modulated process and that sepsis enhances muscle generation of ROS by upregulating PLA(2) activity. Adenosine Diphosphate 112-115 phospholipase A2 group IB Homo sapiens 198-204 10904037-3 2000 We postulated that the physiological changes associated with muscle contraction (i.e., increases in calcium and ADP concentration) stimulate mitochondrial generation of ROS by a phospholipase A(2) (PLA(2))-modulated process and that sepsis enhances muscle generation of ROS by upregulating PLA(2) activity. Adenosine Diphosphate 112-115 phospholipase A2 group IB Homo sapiens 290-296 10904037-5 2000 We found that 1) calcium and ADP stimulated H(2)O(2) formation by diaphragm mitochondria from both control and septic animals; 2) mitochondria from septic animals demonstrated substantially higher H(2)O(2) formation than mitochondria from control animals under basal, calcium-stimulated, and ADP-stimulated conditions; and 3) inhibitors of 14-kDa PLA(2) blocked the enhanced H(2)O(2) generation in all conditions. Adenosine Diphosphate 29-32 phospholipase A2 group IB Homo sapiens 347-353 10873456-11 2000 The domain that has been shown to bind ADP in E. coli SCS is more open in the pig heart, GTP-specific SCS structure. Adenosine Diphosphate 39-42 succinate-CoA ligase ADP-forming subunit beta Sus scrofa 102-105 10873853-1 2000 BACKGROUND: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. Adenosine Diphosphate 153-156 deoxythymidylate kinase Homo sapiens 12-30 10873853-1 2000 BACKGROUND: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. Adenosine Diphosphate 153-156 deoxythymidylate kinase Homo sapiens 32-36 10873853-3 2000 RESULTS: Crystal structures of human TMPK in complex with TMP and ADP, TMP and the ATP analog AppNHp, TMP with ADP and the phosphoryl analog AlF(3), TDP and ADP, and the bisubstrate analog TP(5)A were determined. Adenosine Diphosphate 66-69 deoxythymidylate kinase Homo sapiens 37-41 10873853-3 2000 RESULTS: Crystal structures of human TMPK in complex with TMP and ADP, TMP and the ATP analog AppNHp, TMP with ADP and the phosphoryl analog AlF(3), TDP and ADP, and the bisubstrate analog TP(5)A were determined. Adenosine Diphosphate 111-114 deoxythymidylate kinase Homo sapiens 37-41 10873853-3 2000 RESULTS: Crystal structures of human TMPK in complex with TMP and ADP, TMP and the ATP analog AppNHp, TMP with ADP and the phosphoryl analog AlF(3), TDP and ADP, and the bisubstrate analog TP(5)A were determined. Adenosine Diphosphate 111-114 deoxythymidylate kinase Homo sapiens 37-41 10820018-9 2000 The strong ADP response due to activated PAR4, however, requires prior activation of PAR1 as would normally occur during treatment of platelets with thrombin. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 149-157 10809723-8 2000 Both isoforms stimulated ATP hydrolysis by Hsc70 in an Hsp40-dependent manner through an acceleration of ADP-ATP exchange. Adenosine Diphosphate 105-108 DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 Homo sapiens 55-60 10820018-9 2000 The strong ADP response due to activated PAR4, however, requires prior activation of PAR1 as would normally occur during treatment of platelets with thrombin. Adenosine Diphosphate 11-14 coagulation factor II thrombin receptor Homo sapiens 85-89 10827966-5 2000 The apparent efficiency of platelet adhesion to Fg-beads readily correlated with the proportion of platelets "quantally" activated by doses of ADP, i.e., only ADP-activated platelets appeared to adhere to Fg-beads, with a maximal adhesion efficiency of 6-10% at shear rates of 100-300 s(-1), decreasing with increasing shear rates up to 2000 s(-1). Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 48-50 10827966-5 2000 The apparent efficiency of platelet adhesion to Fg-beads readily correlated with the proportion of platelets "quantally" activated by doses of ADP, i.e., only ADP-activated platelets appeared to adhere to Fg-beads, with a maximal adhesion efficiency of 6-10% at shear rates of 100-300 s(-1), decreasing with increasing shear rates up to 2000 s(-1). Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 205-207 10748134-7 2000 PDK3 activity was stimulated upon reductive acetylation of L1 and L2 when full activation of PDK3 by E2 was avoided (e.g. using free lipoyl domains or ADP-inhibited E2-activated PDK3). Adenosine Diphosphate 151-154 L1 cell adhesion molecule Homo sapiens 59-68 10824686-3 2000 In these fractions, a low level of PLD activity was measured with an exogenous substrate containing phosphatidylinositol-4,5-bisphosphate (PIP2), unresponsive to guanosine triphosphate (GTP)gammaS and adenosine diphosphate (ADP)-ribosylation factor (ARF). Adenosine Diphosphate 201-222 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 10847440-1 2000 BACKGROUND: Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Adenosine Diphosphate 40-43 poly(ADP-ribose) polymerase 1 Homo sapiens 72-99 10847440-1 2000 BACKGROUND: Poly-adenosine diphosphate (ADP)-ribosylation, catalysed by poly(ADP-ribose) polymerase (PARP), is a post-translational modification of nuclear proteins and is involved in a wide range of biological processes including DNA repair, cell proliferation and malignant transformation. Adenosine Diphosphate 40-43 poly(ADP-ribose) polymerase 1 Homo sapiens 101-105 10934601-2 2000 The EC50 values of ADP, inducing the activation and aggregation of thrombocytes, reflect the sequence of the agonist action on various receptors: P2X1, 20-40 nM; P2Y1, 90-110 nM; P2YADP, 120-240 nM. Adenosine Diphosphate 19-22 purinergic receptor P2Y1 Rattus norvegicus 162-166 10934601-3 2000 It was demonstrated that ADP behaves as partial agonist not only with respect to P2X1 receptors, but with respect to P2Y1 receptors as well. Adenosine Diphosphate 25-28 purinergic receptor P2Y1 Rattus norvegicus 117-121 10824686-3 2000 In these fractions, a low level of PLD activity was measured with an exogenous substrate containing phosphatidylinositol-4,5-bisphosphate (PIP2), unresponsive to guanosine triphosphate (GTP)gammaS and adenosine diphosphate (ADP)-ribosylation factor (ARF). Adenosine Diphosphate 224-227 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 35-38 10718337-0 2000 A chimeric rat brain P2Y1 receptor tagged with green-fluorescent protein: high-affinity ligand recognition of adenosine diphosphates and triphosphates and selectivity identical to that of the wild-type receptor. Adenosine Diphosphate 110-132 purinergic receptor P2Y1 Rattus norvegicus 21-25 10814955-1 2000 Poly(ADP-ribose) polymerase (PARP) catalyzes the transfer of successive units of ADP-ribose moiety from NAD(+) covalently to itself and other nuclear acceptor proteins. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 29-33 10742308-10 2000 Ap(n)As inhibited ADP induced increases in [Ca(2+)](i) mediated by P2Y(1) receptors by shifting ADP concentration-response curves to larger concentrations. Adenosine Diphosphate 18-21 purinergic receptor P2Y1 Rattus norvegicus 67-73 10718337-11 2000 The rP2Y1-eGFP receptor has the same ligand selectivity as the rP2Y1-wt receptor (2-MeSADP = 2-MeSATP > ADP > ATPalphaS, ATP >> UTP). Adenosine Diphosphate 87-90 purinergic receptor P2Y1 Rattus norvegicus 4-9 10742308-10 2000 Ap(n)As inhibited ADP induced increases in [Ca(2+)](i) mediated by P2Y(1) receptors by shifting ADP concentration-response curves to larger concentrations. Adenosine Diphosphate 96-99 purinergic receptor P2Y1 Rattus norvegicus 67-73 10708592-2 2000 We separated the fraction free of elongation factor and endogenous transferase, which strongly inhibited the ADP-ribosylation of eEF-2. Adenosine Diphosphate 109-112 eukaryotic translation elongation factor 2 Rattus norvegicus 129-134 10759852-5 2000 Hence, ADP must be generating an agonist, other than thromboxane A2, via an aspirin-sensitive pathway, which is capable of activating p38 kinase. Adenosine Diphosphate 7-10 mitogen-activated protein kinase 14 Homo sapiens 134-137 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 105-108 mitogen-activated protein kinase 14 Homo sapiens 117-120 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 105-108 mitogen-activated protein kinase 14 Homo sapiens 255-258 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 225-228 mitogen-activated protein kinase 14 Homo sapiens 117-120 10759852-9 2000 These results demonstrate that ADP causes the generation of a factor in human platelets, which can activate p38 kinase, and that this response is mediated by the P2Y1 receptor. Adenosine Diphosphate 31-34 mitogen-activated protein kinase 14 Homo sapiens 108-111 10759852-0 2000 The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets. Adenosine Diphosphate 27-30 mitogen-activated protein kinase 14 Homo sapiens 39-42 10759852-2 2000 In nonaspirinated human platelets ADP activated p38 MAP kinase in both a time-and concentration-dependent manner, suggesting that ADP-induced p38 MAP kinase activation requires generation of thromboxane A2. Adenosine Diphosphate 34-37 mitogen-activated protein kinase 14 Homo sapiens 48-51 10759852-2 2000 In nonaspirinated human platelets ADP activated p38 MAP kinase in both a time-and concentration-dependent manner, suggesting that ADP-induced p38 MAP kinase activation requires generation of thromboxane A2. Adenosine Diphosphate 34-37 mitogen-activated protein kinase 14 Homo sapiens 142-145 10759852-2 2000 In nonaspirinated human platelets ADP activated p38 MAP kinase in both a time-and concentration-dependent manner, suggesting that ADP-induced p38 MAP kinase activation requires generation of thromboxane A2. Adenosine Diphosphate 130-133 mitogen-activated protein kinase 14 Homo sapiens 48-51 10759852-2 2000 In nonaspirinated human platelets ADP activated p38 MAP kinase in both a time-and concentration-dependent manner, suggesting that ADP-induced p38 MAP kinase activation requires generation of thromboxane A2. Adenosine Diphosphate 130-133 mitogen-activated protein kinase 14 Homo sapiens 142-145 10713121-7 2000 Kinetic analyses revealed that ADP-induced platelets had about the same number of binding sites (B(max)) as thrombin-induced platelets, but their affinity (K(d)) for soluble collagen was 3.7-12.7-fold lower, suggesting that activated integrin alpha(2)beta(1) induced by ADP is different from that induced by thrombin. Adenosine Diphosphate 31-34 coagulation factor II, thrombin Homo sapiens 308-316 10712415-8 2000 ADP produced only an inhibitory effect, reducing PAI-1 mRNA levels by 63% (P<0.05) at 3 hours. Adenosine Diphosphate 0-3 serpin family E member 1 Rattus norvegicus 49-54 10686099-0 2000 Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation. Adenosine Diphosphate 68-71 hexokinase 1 Homo sapiens 39-51 10712415-10 2000 Further studies revealed that exposure of RASMCs to either ATP or ADP for 3 hours inhibited both UTP- and angiotensin II-stimulated PAI-1 expression by up to 90% (P<0.001). Adenosine Diphosphate 66-69 angiotensinogen Rattus norvegicus 97-120 10712415-10 2000 Further studies revealed that exposure of RASMCs to either ATP or ADP for 3 hours inhibited both UTP- and angiotensin II-stimulated PAI-1 expression by up to 90% (P<0.001). Adenosine Diphosphate 66-69 serpin family E member 1 Rattus norvegicus 132-137 10868950-7 2000 Kir6.2 subunits form the K+ ion-permeable pore and primarily confer inhibition of the channels by ATP, while SUR1 subunits confer activation of the channels by MgADP and K+ channel openers, such as diazoxide, as well as inhibition by sulfonylureas. Adenosine Diphosphate 160-165 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 Mus musculus 109-113 10823244-2 2000 The normal regulation of insulin secretion is coupled to glucose metabolism in the pancreatic B cell, a major but not exclusive signal for secretion being closure of K+ ATP (adenosine" triphosphate)-dependent channels in the cell membrane through an increase in cytosolic ATP/adenosine diphosphate. Adenosine Diphosphate 276-297 insulin Homo sapiens 25-32 10727016-7 2000 Immunocytochemical analyses indicated that RhoA was localized preferentially to the cortical granules; this was confirmed by experiments of [32P]ADP-ribosylation with C3 in isolated cortical granules. Adenosine Diphosphate 145-148 ras homolog family member A Homo sapiens 43-47 10691699-1 2000 P2Y(1) receptors are activated by ADP and occur on endothelial cells, smooth muscle, epithelial cells, lungs, pancreas, platelets, and in the central nervous system. Adenosine Diphosphate 34-37 P2Y purinoceptor 1 Meleagris gallopavo 0-6 10662717-7 2000 The increased PDH(a) may have resulted from alterations in the acetyl-CoA, ADP(f), pyruvate, NADH, and H(+) concentrations leading to a lower relative activity of PDH kinase, whereas the similar values at 75% VO(2 max) may have reflected maximal activation. Adenosine Diphosphate 75-78 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 14-17 10681547-9 2000 Kinetic parameters derived from purified preparations of hepatic ATPDase indicated V(max) of 8.5 units/mg of protein with apparent K(m) of 100 microM for both ATP or ADP as substrates. Adenosine Diphosphate 166-169 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 65-72 10716190-2 2000 The RhoA/RhoGDI complex, purified to greater than 98% at high yield from the yeast cytosolic fraction, could be stoichiometrically ADP-ribosylated by Clostridium botulinum C3 exoenzyme, contained stoichiometric GDP, and could be nucleotide exchanged fully with [3H]GDP or partially with GTP in the presence of submicromolar Mg2+. Adenosine Diphosphate 131-134 ras homolog family member A Homo sapiens 4-8 12845727-3 2000 The results showed that platelet surface binding sites of fibrinogen were 65.38 +/- 3.62 in the resting state and 65.25 +/- 5.78 after activated by adenosine diphosphate, showing no significant difference as compared with control group (P > 0.05). Adenosine Diphosphate 148-169 fibrinogen beta chain Homo sapiens 58-68 10656876-2 1999 Nucleoside [corrected] triphosphate diphosphohydrolase-1 (NTPDase-1, identical to CD39), the major vascular endothelial ectonucleotidase, is responsible for the hydrolysis of both extracellular ATP and ADP in the blood plasma to AMP. Adenosine Diphosphate 202-205 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 58-67 10590060-0 1999 A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase. Adenosine Diphosphate 14-35 coagulation factor II thrombin receptor Homo sapiens 92-96 10590060-6 1999 A comparison between the effects of PI 3-kinase inhibitors and apyrase strongly suggest that the late, ADP-dependent, PtdIns(3,4)P(2) accumulation is necessary for PAR1-induced irreversible aggregation. Adenosine Diphosphate 103-106 coagulation factor II thrombin receptor Homo sapiens 164-168 10567235-5 1999 The pleckstrin-homology (PH) domains of the nucleotide exchange factors, ADP-ribosylation factor nucleotide-binding-site opener (ARNO) and general receptor for 3-phosphoinositides (GRP1), which have a high affinity and specificity for PtdIns(3,4,5)P(3), were fused to green fluorescent protein and used to examine the subcellular localization of PtdIns(3,4,5)P(3) generation in living 3T3-L1 adipocytes. Adenosine Diphosphate 73-76 cytohesin 2 Homo sapiens 129-133 10567235-5 1999 The pleckstrin-homology (PH) domains of the nucleotide exchange factors, ADP-ribosylation factor nucleotide-binding-site opener (ARNO) and general receptor for 3-phosphoinositides (GRP1), which have a high affinity and specificity for PtdIns(3,4,5)P(3), were fused to green fluorescent protein and used to examine the subcellular localization of PtdIns(3,4,5)P(3) generation in living 3T3-L1 adipocytes. Adenosine Diphosphate 73-76 cytohesin 3 Homo sapiens 181-185 10551820-4 1999 For both IKKalpha and IKKbeta, the product ADP was a competitive inhibitor versus ATP and a non-competitive inhibitor versus IkappaBalpha. Adenosine Diphosphate 43-46 NFKB inhibitor alpha Homo sapiens 125-137 10542201-1 1999 The Na/K-ATPase has been shown to bind 1 and 0.5 mol of (32)P/mol of alpha-chain in the presence [gamma-(32)P]ATP and [alpha-(32)P]ATP, respectively, accompanied by a maximum accumulation of 0.5 mol of ADP-sensitive phosphoenzyme (NaE1P) and potassium-sensitive phosphoenzyme (E2P). Adenosine Diphosphate 202-205 Fc gamma receptor and transporter Homo sapiens 69-80 10523638-0 1999 An ATP/ADP-dependent molecular switch regulates the stability of p53-DNA complexes. Adenosine Diphosphate 7-10 tumor protein p53 Homo sapiens 65-68 10523638-2 1999 We now show, for the first time, that the interaction of p53 with DNA can be stabilized by small molecules, such as ADP and dADP. Adenosine Diphosphate 116-119 tumor protein p53 Homo sapiens 57-60 10523638-3 1999 Our results also indicate an ATP/ADP molecular switch mechanism which determines the off-on states for p53-DNA binding. Adenosine Diphosphate 33-36 tumor protein p53 Homo sapiens 103-106 10523638-4 1999 This ATP/ADP molecular switch requires dimer-dimer interaction of the p53 tetramer. Adenosine Diphosphate 9-12 tumor protein p53 Homo sapiens 70-73 10523638-6 1999 Low-level ATPase activity is nonetheless associated with ATP-p53 interaction and may serve to regenerate ADP-p53, thus recycling the high-affinity DNA binding form of p53. Adenosine Diphosphate 105-108 tumor protein p53 Homo sapiens 61-64 10523638-6 1999 Low-level ATPase activity is nonetheless associated with ATP-p53 interaction and may serve to regenerate ADP-p53, thus recycling the high-affinity DNA binding form of p53. Adenosine Diphosphate 105-108 tumor protein p53 Homo sapiens 109-112 10523638-6 1999 Low-level ATPase activity is nonetheless associated with ATP-p53 interaction and may serve to regenerate ADP-p53, thus recycling the high-affinity DNA binding form of p53. Adenosine Diphosphate 105-108 tumor protein p53 Homo sapiens 109-112 10523638-7 1999 The ATP/ADP regulatory mechanism applies to two distinct types of p53 interaction with DNA, namely, sequence-specific DNA binding (via the core domain of the p53 protein) and binding to sites of DNA damage (via the C-terminal domain). Adenosine Diphosphate 8-11 tumor protein p53 Homo sapiens 66-69 10523638-7 1999 The ATP/ADP regulatory mechanism applies to two distinct types of p53 interaction with DNA, namely, sequence-specific DNA binding (via the core domain of the p53 protein) and binding to sites of DNA damage (via the C-terminal domain). Adenosine Diphosphate 8-11 tumor protein p53 Homo sapiens 158-161 10523638-8 1999 Further studies indicate that ADP not only stabilizes p53-DNA complexes but also renders the complexes susceptible to dissociation by specific p53 binding proteins. Adenosine Diphosphate 30-33 tumor protein p53 Homo sapiens 54-57 10523638-8 1999 Further studies indicate that ADP not only stabilizes p53-DNA complexes but also renders the complexes susceptible to dissociation by specific p53 binding proteins. Adenosine Diphosphate 30-33 tumor protein p53 Homo sapiens 143-146 10523638-9 1999 We propose a model in which the DNA binding functions of p53 are regulated by an ATP/ADP molecular switch, and we suggest that this mechanism may function during the cellular response to DNA damage. Adenosine Diphosphate 85-88 tumor protein p53 Homo sapiens 57-60 10574795-4 1999 The mitochondrion-bound hexokinase I is believed to optimize the ATP/ADP exchange between glucose phosphorylation and the mitochondrial oxidative phosphorylation reactions. Adenosine Diphosphate 69-72 hexokinase 1 Homo sapiens 24-36 10539883-9 1999 All samples from patients confirmed to have VWD following specific VWF studies [N = 9; 3 x Type 1, 1 x Type 3, 1 x Type 2A, 4 x Type 2B] gave prolonged CTs (>/= 200 s) for both C/ADP and C/Epi membranes; in contrast, all patients yielding normal CT values were found to yield normal VWF results (i.e., were found not to suffer from VWD). Adenosine Diphosphate 182-185 von Willebrand factor Homo sapiens 67-70 10512757-5 1999 When testing the effect of each inhibitor individually we found the strongest inhibition of thrombin-induced PtdIns(3,4)P(2) production with the ADP scavenger system CP/CPK. Adenosine Diphosphate 145-148 coagulation factor II, thrombin Homo sapiens 92-100 10512721-7 1999 When GroES was present, ATP as well as ADP and AMP-PNP were effective in reducing the affinity between GroEL and the refolding intermediate of alpha-lactalbumin. Adenosine Diphosphate 39-42 lactalbumin alpha Homo sapiens 143-160 10512757-0 1999 Formation of PI 3-kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP. Adenosine Diphosphate 159-162 coagulation factor II, thrombin Homo sapiens 50-58 10521087-4 1999 The addition of inhibitors 5 minutes after adenosine diphosphate-induced fibrinogen binding also resulted in decreased tyrosine phosphorylation and dissociation of approximately 50% of bound fibrinogen within 60 minutes but failed to cause dissociation of irreversibly bound fibrinogen. Adenosine Diphosphate 43-64 fibrinogen beta chain Homo sapiens 73-83 10516124-9 1999 Reduced PDH activity occurred with ACID and may have resulted from alterations in the concentrations of acetyl-CoA, free ADP, pyruvate, NADH, and H(+), leading to greater relative activity of the kinase. Adenosine Diphosphate 121-124 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 8-11 10531338-0 1999 Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs. Adenosine Diphosphate 107-110 myosin Ib Rattus norvegicus 19-31 10531338-5 1999 Several of these N(6)-modified ADP analogs were more than 40-fold more potent at inhibiting ATP hydrolysis by Y61G than wild-type myosin-Ibeta; in doing so, these analogs locked Y61G myosin-Ibeta tightly to actin. Adenosine Diphosphate 31-34 myosin Ib Rattus norvegicus 130-142 10531338-5 1999 Several of these N(6)-modified ADP analogs were more than 40-fold more potent at inhibiting ATP hydrolysis by Y61G than wild-type myosin-Ibeta; in doing so, these analogs locked Y61G myosin-Ibeta tightly to actin. Adenosine Diphosphate 31-34 myosin Ib Rattus norvegicus 183-195 10531338-8 1999 Introduction of Y61G myosin-Ibeta molecules into a cell should permit selective inhibition by N(6)-modified ADP analogs of cellular processes dependent on myosin-Ibeta. Adenosine Diphosphate 108-111 myosin Ib Rattus norvegicus 21-33 10531338-8 1999 Introduction of Y61G myosin-Ibeta molecules into a cell should permit selective inhibition by N(6)-modified ADP analogs of cellular processes dependent on myosin-Ibeta. Adenosine Diphosphate 108-111 myosin Ib Rattus norvegicus 155-167 10504326-11 1999 While regulation of Ca(2+) influx did not alter RhoA translocation, it reduced in vitro ADP-ribosylation of RhoA (P(2)<0. Adenosine Diphosphate 88-91 ras homolog family member A Homo sapiens 108-112 10446085-8 1999 Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. Adenosine Diphosphate 63-66 coagulation factor II, thrombin Homo sapiens 179-187 10548063-8 1999 In the presence of saturating magnesium, potassium, and MgADP, the apparent rate constant for the release of EcDHFR from wild-type GroEL at 22 degrees C reaches a limiting value of 0.014 s(-1). Adenosine Diphosphate 56-61 dihydrofolate reductase Escherichia coli 109-115 10548063-8 1999 In the presence of saturating magnesium, potassium, and MgADP, the apparent rate constant for the release of EcDHFR from wild-type GroEL at 22 degrees C reaches a limiting value of 0.014 s(-1). Adenosine Diphosphate 56-61 GroEL Escherichia coli 131-136 10548063-9 1999 For the single ring mutant of GroEL, the rate of EcDHFR release under the same conditions reaches a limiting value of 0.024 s(-1), suggesting that inter-ring negative cooperativity exists for MgADP-induced substrate release. Adenosine Diphosphate 192-197 GroEL Escherichia coli 30-35 10548063-9 1999 For the single ring mutant of GroEL, the rate of EcDHFR release under the same conditions reaches a limiting value of 0.024 s(-1), suggesting that inter-ring negative cooperativity exists for MgADP-induced substrate release. Adenosine Diphosphate 192-197 dihydrofolate reductase Escherichia coli 49-55 10548063-10 1999 The data suggest that MgADP preferentially binds to one conformation of GroEL, that with the faster apparent rate constant for EcDHFR release, and induces a conformational change leading to more rapid release of substrate protein. Adenosine Diphosphate 22-27 GroEL Escherichia coli 72-77 10548063-10 1999 The data suggest that MgADP preferentially binds to one conformation of GroEL, that with the faster apparent rate constant for EcDHFR release, and induces a conformational change leading to more rapid release of substrate protein. Adenosine Diphosphate 22-27 dihydrofolate reductase Escherichia coli 127-133 10486282-4 1999 TPO demonstrated a synergistic effect on the exocytosis induced by suboptimal doses of adenosine diphosphate (ADP) and the thrombin receptor agonist peptide (TRAP). Adenosine Diphosphate 87-108 thrombopoietin Homo sapiens 0-3 10486282-4 1999 TPO demonstrated a synergistic effect on the exocytosis induced by suboptimal doses of adenosine diphosphate (ADP) and the thrombin receptor agonist peptide (TRAP). Adenosine Diphosphate 110-113 thrombopoietin Homo sapiens 0-3 10486282-5 1999 We detected synergistic effects of TPO on the ADP or TRAP induced Ca(2+) mobilization in a small range of very low agonist concentrations. Adenosine Diphosphate 46-49 thrombopoietin Homo sapiens 35-38 10486282-6 1999 The TPO synergism on Ca(2+) mobilization and CD62P expression was measurable in different, nonoverlapping ranges of ADP or TRAP concentrations. Adenosine Diphosphate 116-119 thrombopoietin Homo sapiens 4-7 10464255-3 1999 By contrast, stabilizing actin filaments with jasplakinolide prevented cytochalasin D-, latrunculin A-, and ADP-induced fibrinogen binding. Adenosine Diphosphate 108-111 fibrinogen beta chain Homo sapiens 120-130 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 42-52 10464255-4 1999 Cytochalasin D- and latrunculin A-induced fibrinogen was inhibited by ADP scavengers, suggesting that subthreshold concentrations of ADP provided the stimulus for the actin filament turnover required to see cytochalasin D and latrunculin A effects. Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 42-52 11721406-6 1999 CONCLUSION: The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e. thromboxane, secreted ADP and cAMP, protein kinase C (PKC) activation presumably being the common passage for the signaling. Adenosine Diphosphate 160-163 fibrinogen beta chain Homo sapiens 80-82 10548063-2 1999 In this paper, we investigate the effects of potassium, magnesium, and MgADP on the release of the EcDHFR late folding intermediate from GroEL. Adenosine Diphosphate 71-76 dihydrofolate reductase Escherichia coli 99-105 10548063-2 1999 In this paper, we investigate the effects of potassium, magnesium, and MgADP on the release of the EcDHFR late folding intermediate from GroEL. Adenosine Diphosphate 71-76 GroEL Escherichia coli 137-142 10548063-4 1999 In the absence of potassium, magnesium, and ADP, approximately 80-90% of GroEL resides in the form with the faster rate of release. Adenosine Diphosphate 44-47 GroEL Escherichia coli 73-78 10548063-6 1999 MgADP at low concentrations (0-50 microM) shifts the distribution of GroEL forms toward the form with the faster release rate, and this effect is also potassium dependent. Adenosine Diphosphate 0-5 GroEL Escherichia coli 69-74 10405323-4 1999 Thrombin, a thrombin receptor agonist peptide, a thromboxane A(2) analogue, collagen, crosslinking the glycoprotein VI, ADP, and epinephrine, but not phorbol 12, 13-dibutyrate activated p38. Adenosine Diphosphate 120-123 coagulation factor II, thrombin Homo sapiens 0-8 10435998-9 1999 In addition to antagonizing high-affinity block by tolbutamide, PIP(2) also altered the stimulatory action of the PCOs, diazoxide and MgADP. Adenosine Diphosphate 134-139 prolactin induced protein Homo sapiens 64-67 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 12-22 10400622-4 1999 In the final complex, BiP is bound in the ADP form with its peptide binding pocket occupied. Adenosine Diphosphate 42-45 heat shock protein family A (Hsp70) member 5 Homo sapiens 22-25 10381582-4 1999 MgADP and diazoxide interact with SUR1 to promote channel activity. Adenosine Diphosphate 0-5 ATP-binding cassette sub-family C member 8 Xenopus laevis 34-38 10426341-7 1999 In platelets activated with 1 microM ADP, clinically relevant concentrations of tirofiban caused inhibition of fibrinogen binding ranging from 17% to 88%. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 111-121 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 104-114 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 12-22 10418796-5 1999 ADP-induced fibrinogen binding was found to be a low threshold activation event (40% of platelets bound fibrinogen in response to 0.2 microM ADP). Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 104-114 10411706-8 1999 In addition, the binding of radiolabeled fibrinogen to activated normal platelets and platelet aggregation in response to ADP were both decreased by fibrinogen fragments. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 41-51 10411706-8 1999 In addition, the binding of radiolabeled fibrinogen to activated normal platelets and platelet aggregation in response to ADP were both decreased by fibrinogen fragments. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 149-159 10373472-5 1999 It is this form of the UL9 homodimer that upon interaction with ICP8, promotes the unwinding of Box I coupled to the hydrolysis of ATP to ADP and Pi. Adenosine Diphosphate 138-141 DNA replication origin-binding helicase Human alphaherpesvirus 1 23-26 10387081-5 1999 Small-angle X-ray scattering data from the mutant hexokinase I in the presence of glucose/phosphate, glucose/glucose 6-phosphate, and glucose/ADP/Mg2+/AlF3 are consistent with a rodlike conformation for the monomer similar to that observed in crystal structures of the hexokinase I dimer. Adenosine Diphosphate 142-145 hexokinase 1 Homo sapiens 50-62 10398692-0 1999 Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites. Adenosine Diphosphate 16-19 CF transmembrane conductance regulator Homo sapiens 52-56 10401561-21 1999 These results suggest that the vasodilatory action of intravascular ATP in the coronary circulation should be attributed to the dual and equal activities of adenosine and ADP acting at P1 and P2Y1 receptors respectively. Adenosine Diphosphate 171-174 purinergic receptor P2Y1 Rattus norvegicus 192-196 10404775-2 1999 ), a potent and selective inhibitor of ADP-induced platelet aggregation, significantly inhibited, in the presence of platelets, ex vivo thrombin generation triggered by low concentrations of tissue factor. Adenosine Diphosphate 39-42 coagulation factor II Rattus norvegicus 136-144 10411652-5 1999 We show here that PtdIns, PtdIns4P, PtdIns3,4P2, PtdIns4,5P2 and PtdInsP3 enhance not only the C3-dependent ADP-ribosylation, but also the GDP/GTP exchange in the RhoA component of the prenylated RhoA/Rho-GDI complex. Adenosine Diphosphate 108-111 ras homolog family member A Homo sapiens 163-167 10411652-5 1999 We show here that PtdIns, PtdIns4P, PtdIns3,4P2, PtdIns4,5P2 and PtdInsP3 enhance not only the C3-dependent ADP-ribosylation, but also the GDP/GTP exchange in the RhoA component of the prenylated RhoA/Rho-GDI complex. Adenosine Diphosphate 108-111 ras homolog family member A Homo sapiens 196-200 10411652-6 1999 In contrast, in the nonprenylated RhoA/Rho-GDI complex, the levels of ADP-ribosylation and GDP/GTP exchange are of the same order as those measured on free RhoA and are not modified by phosphoinositides. Adenosine Diphosphate 70-73 ras homolog family member A Homo sapiens 34-38 10379819-3 1999 In our conditions, L-arginine (at 100-6000 micromol/L) was able to influence the response of human platelets stimulated with adenosine 5-diphosphate and collagen both in PRP and in whole blood. Adenosine Diphosphate 125-148 prion protein Homo sapiens 170-173 10331633-2 1999 A detailed kinetic analysis of the automodification reaction of PARP in the presence of nicked dsDNA indicates that protein-poly(ADP-ribosyl)ation probably occurs via a sequential mechanism since enzyme-bound ADP-ribose chains are not reaction intermediates. Adenosine Diphosphate 129-132 poly(ADP-ribose) polymerase 1 Homo sapiens 64-68 10222010-5 1999 Here, we present a simple photometric assay that uses a cyclic detection system which, due to the sequential action of pyruvate kinase and hexokinase, results in an exponential increase of ADP and glucose 6-phosphate. Adenosine Diphosphate 189-192 hexokinase 1 Homo sapiens 139-149 10086317-2 1999 ADP induces platelet shape change, exposure of fibrinogen binding sites, aggregation, and influx and intracellular mobilization of Ca2+. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 47-57 10082530-1 1999 Mammalian poly(ADP-ribose) polymerase (PARP) is a nuclear chromatin-associated protein with a molecular mass of 114 kDa that catalyzes the transfer of ADP-ribose units from NAD+ to nuclear proteins that are located within chromatin. Adenosine Diphosphate 15-18 poly(ADP-ribose) polymerase 1 Homo sapiens 39-43 10037499-3 1999 ANT2 protein exchanges intramitochondrial ATP for cytoplasmic ADP. Adenosine Diphosphate 62-65 solute carrier family 25 member 5 Rattus norvegicus 0-4 10328216-3 1999 As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. Adenosine Diphosphate 29-32 ras homolog family member A Homo sapiens 95-99 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 0-10 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 22-25 integrin subunit beta 3 Homo sapiens 79-85 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 114-117 fibrinogen beta chain Homo sapiens 0-10 10329065-7 1999 Fibrinogen binding to ADP-stimulated platelets was significantly higher in the GPIIIa-Pro33 positive group at all ADP concentrations (<0.0001; two way ANOVA). Adenosine Diphosphate 114-117 integrin subunit beta 3 Homo sapiens 79-85 10329065-10 1999 CONCLUSIONS: The increased tendency of platelets from patients with the Pro33 form of GPIIIa may predispose patients with this allele to a higher risk of acute thrombotic events, and argues for selective use of therapeutic agents that inhibit ADP-mediated platelet activation in occlusive vascular disease states. Adenosine Diphosphate 243-246 integrin subunit beta 3 Homo sapiens 86-92 10206961-2 1999 APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively. Adenosine Diphosphate 43-46 apoptotic peptidase activating factor 1 Homo sapiens 0-6 10194306-3 1999 PARP was effectively mono(ADP-ribosyl)ated both in solution and via an activity gel assay following SDS-PAGE with 20 microM or lower concentrations of [32P]-3"-dNAD+ as the ADP-ribosylation substrate. Adenosine Diphosphate 26-29 poly(ADP-ribose) polymerase 1 Homo sapiens 0-4 10082941-2 1999 In the presence of fluoride, Mg2+ and MgADP form a complex that traps the active site of S1 and inhibits myosin ATPase. Adenosine Diphosphate 38-43 proteasome 26S subunit, non-ATPase 1 Homo sapiens 89-91 10333288-5 1999 Activation of PhK by a variety of mechanisms known or thought to act through its regulatory subunits (phosphorylation, ADP binding, or alkaline pH) increased the binding of the holoenzyme to immobilized mAb gamma79, indicating that activation by any of these distinct mechanisms involves repositioning of the portion of the catalytic domain of the gamma subunit containing the epitope for mAb gamma79. Adenosine Diphosphate 119-122 phosphorylase kinase regulatory subunit alpha 2 Homo sapiens 14-17 9950763-3 1999 In a simplified model using COS-7 cells, we demonstrate acquisition of an ATP-, ADP-, AMP-, and adenosine (ADO)-regulated halide permeability specifically following expression of wild-type (wt) cystic fibrosis transmembrane conductance regulator (CFTR). Adenosine Diphosphate 80-83 CF transmembrane conductance regulator Homo sapiens 247-251 10554171-11 1999 A cocktail of blocking MAbs to CD62P, CD15, GPIIb/IIIa and the CD11b/CD18 complex had no effect on unstimulated samples, whilst totally inhibiting aggregation induced by 10(-5) M ADP, suggesting that the PLAs in unstimulated blood were preformed in vivo. Adenosine Diphosphate 179-182 integrin subunit beta 2 Homo sapiens 69-73 9872733-5 1999 The recent determination of the three-dimensional structure of the broad spectrum aminoglycoside kinase APH(3")-IIIa complexed with the product ADP, in addition to mechanistic and mutagenic studies on this and related enzymes, has added a great deal to our understanding of this class of antibiotic resistance enzyme. Adenosine Diphosphate 144-147 acylaminoacyl-peptide hydrolase Homo sapiens 104-107 10078199-0 1999 Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Adenosine Diphosphate 96-99 BCL2 like 1 Homo sapiens 0-6 10078199-5 1999 Bcl-xL expression allows growth factor-deprived cells to maintain sufficient mitochondrial ATP/ADP exchange to sustain coupled respiration. Adenosine Diphosphate 95-98 BCL2 like 1 Homo sapiens 0-6 10078199-7 1999 Efficient exchange of ADP for ATP is promoted by Bcl-xL expression permitting oxidative phosphorylation to be regulated by cellular ATP/ADP levels and allowing mitochondria to adapt to changes in metabolic demand. Adenosine Diphosphate 22-25 BCL2 like 1 Homo sapiens 49-55 10078199-7 1999 Efficient exchange of ADP for ATP is promoted by Bcl-xL expression permitting oxidative phosphorylation to be regulated by cellular ATP/ADP levels and allowing mitochondria to adapt to changes in metabolic demand. Adenosine Diphosphate 136-139 BCL2 like 1 Homo sapiens 49-55 16801070-3 1999 Platelet aggregation stimulated with <0.5 U/ml thrombin, 0.75-3 microM adenosine diphosphate (ADP) or 1 microg/ml collagen was significantly lower in glyburide-treated platelets, but not in insulin-treated platelets, than in untreated ones (control). Adenosine Diphosphate 97-100 insulin Homo sapiens 193-200 9886057-2 1999 The vesicles derived from the cerebellum were able to accumulate Ca2+ in a medium containing ADP when either glucose 6-phosphate and hexokinase or fructose 1,6-bisphosphate and phosphofructokinase were added to the medium. Adenosine Diphosphate 93-96 hexokinase 1 Homo sapiens 102-143 9857072-2 1998 We have pursued equilibrium binding experiments to examine the affinity of Ncd for microtubules in the presence of the ATP nonhydrolyzable analog 5"-adenylyl-beta, gamma-imidodiphosphate (AMP-PNP), ADP, or ADP + Pi using both dimeric (MC1) and monomeric (MC6) Ncd constructs expressed in Escherichia coli. Adenosine Diphosphate 198-201 non-claret disjunctional Drosophila melanogaster 75-78 9857072-2 1998 We have pursued equilibrium binding experiments to examine the affinity of Ncd for microtubules in the presence of the ATP nonhydrolyzable analog 5"-adenylyl-beta, gamma-imidodiphosphate (AMP-PNP), ADP, or ADP + Pi using both dimeric (MC1) and monomeric (MC6) Ncd constructs expressed in Escherichia coli. Adenosine Diphosphate 206-209 non-claret disjunctional Drosophila melanogaster 75-78 9857072-8 1998 These results are consistent with a model for the ATPase cycle in which ATP hydrolysis occurs on the microtubule followed by detachment as the Ncd.ADP.Pi intermediate. Adenosine Diphosphate 147-150 non-claret disjunctional Drosophila melanogaster 143-146 9887967-5 1998 Inhibition of RhoA activity by a membrane-permeant ADP-ribosylating bacterial exoenzyme, DC3B, causes severe depression of the tonic component of agonist-induced contraction, suggesting that this component is largely due to Ca(2+)-sensitization. Adenosine Diphosphate 51-54 ras homolog family member A Homo sapiens 14-18 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 13-16 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 9858246-0 1998 The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. Adenosine Diphosphate 64-67 purinergic receptor P2Y1 Rattus norvegicus 4-8 9858246-10 1998 In summary, these results demonstrate that the platelet P2Y1 receptor responsible for the initiation of aggregation in response to ADP is not the target of clopidogrel. Adenosine Diphosphate 131-134 purinergic receptor P2Y1 Rattus norvegicus 56-60 9813009-4 1998 UCP-1 function is inhibited by the binding of purine nucleotides, with GTP/GDP being more potent than ATP/ADP. Adenosine Diphosphate 106-109 uncoupling protein 1 Rattus norvegicus 0-5 9813037-7 1998 Our results are compatible with nonphosphorylated RLC acting as a repressor and with LC17 isoforms modulating the MgADP affinity and, consequently, rate of cooperative cycling of nonphosphorylated cross-bridges. Adenosine Diphosphate 114-119 myosin light chain 6 Homo sapiens 85-89 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 122-143 tankyrase Homo sapiens 12-21 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 122-143 telomeric repeat binding factor 1 Homo sapiens 74-78 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 122-143 tankyrase Homo sapiens 83-92 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 145-148 tankyrase Homo sapiens 12-21 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 145-148 telomeric repeat binding factor 1 Homo sapiens 74-78 9822378-4 1998 Recombinant tankyrase was found to have PARP activity in vitro, with both TRF1 and tankyrase functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Adenosine Diphosphate 145-148 tankyrase Homo sapiens 83-92 9869170-0 1998 Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets. Adenosine Diphosphate 9-12 coagulation factor II, thrombin Homo sapiens 37-45 9869170-0 1998 Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets. Adenosine Diphosphate 9-12 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-69 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 13-16 coagulation factor II, thrombin Homo sapiens 83-91 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 13-16 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 184-187 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 140-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 38-41 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 140-143 coagulation factor II, thrombin Homo sapiens 83-91 9869170-4 1998 In contrast, ADP is able to stimulate PLD in the presence of low concentrations of thrombin that alone have little or no effect, suggesting ADP may play an amplifying role in platelet PLD activation. Adenosine Diphosphate 140-143 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 184-187 9869170-6 1998 ARL 66096 also abolishes the PLD activation by ADP observed in the presence of low concentrations of thrombin, confirming that the antagonist inhibits an ADP-dependent component of the response. Adenosine Diphosphate 47-50 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 9869170-6 1998 ARL 66096 also abolishes the PLD activation by ADP observed in the presence of low concentrations of thrombin, confirming that the antagonist inhibits an ADP-dependent component of the response. Adenosine Diphosphate 47-50 coagulation factor II, thrombin Homo sapiens 101-109 9869170-9 1998 Based on these findings, we conclude that ADP secretion and activation of purinergic ADP receptors is an important amplification mechanism in the signal transduction pathways leading to PLD activation in human platelets. Adenosine Diphosphate 42-45 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 186-189 9787162-3 1998 Since the Pena and Penb allelic forms of GPIIIa are distinguished by a single Arg143Gln amino acid substitution within the RGD binding domain of GPIIIa and anti-Pena human alloantibodies have been shown to bind GPIIb-IIIa on the platelet surface and inhibit ADP-induced platelet aggregation, we expressed both forms of this integrin in Chinese hamster ovary (CHO) cells and examined the relative adhesive properties. Adenosine Diphosphate 258-261 integrin subunit beta 3 Homo sapiens 41-47 9733971-7 1998 A 2-fold increase of Kd value for ATP-receptor interaction was observed in the presence of 2-MeSATP (60 nM) or ADP (250 nM) without any modulation of Bmax value, confirming that inhibitory effects of these compounds are competitive in nature. Adenosine Diphosphate 111-114 purinergic receptor P2Y1 Rattus norvegicus 34-46 9788896-5 1998 The role of protein phosphatases in termination of the ADP-stimulated respiratory burst of AM was examined with calyculin A (CA) (25-75 nM) or okadaic acid (OA) (1-5 microM), two inhibitors of protein phosphatase 1 and 2a (PP1;PP2a). Adenosine Diphosphate 55-58 inorganic pyrophosphatase 1 Homo sapiens 223-226 9724313-4 1998 We found that VEGF was secreted during the in vitro aggregation of platelet-rich plasma induced by thrombin, collagen, epinephrine, and ADP (range 23-518 pg VEGF/ml). Adenosine Diphosphate 136-139 vascular endothelial growth factor A Homo sapiens 14-18 9857975-2 1998 We have now investigated the effects of soluble A beta on platelet function and have found that low levels (0.1-1 nM) of soluble A beta augment ADP-dependent platelet aggregation and translocation of focal adhesion kinase to the platelet cytoskeleton. Adenosine Diphosphate 144-147 amyloid beta precursor protein Homo sapiens 129-135 9857975-3 1998 Addition of A beta to gel-filtered platelets along with concentrations of adenosine diphosphate (ADP) producing submaximal aggregation responses increased the aggregation response by over 2-fold depending on the ADP:A beta ratios. Adenosine Diphosphate 74-95 amyloid beta precursor protein Homo sapiens 216-222 9857975-3 1998 Addition of A beta to gel-filtered platelets along with concentrations of adenosine diphosphate (ADP) producing submaximal aggregation responses increased the aggregation response by over 2-fold depending on the ADP:A beta ratios. Adenosine Diphosphate 97-100 amyloid beta precursor protein Homo sapiens 216-222 9857975-3 1998 Addition of A beta to gel-filtered platelets along with concentrations of adenosine diphosphate (ADP) producing submaximal aggregation responses increased the aggregation response by over 2-fold depending on the ADP:A beta ratios. Adenosine Diphosphate 212-215 amyloid beta precursor protein Homo sapiens 12-18 9756891-0 1998 Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain. Adenosine Diphosphate 31-34 cytohesin 1 Homo sapiens 69-80 9756891-0 1998 Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain. Adenosine Diphosphate 31-34 cytohesin 1 Homo sapiens 89-93 9831901-13 1998 A 1 u ml(-1) apyrase III solution generated 20 microM ADP from 0.1 mM ATP within 15 s. This concentration of ADP was sufficient to produce maximal activation of P2Y1 receptors. Adenosine Diphosphate 54-57 purinergic receptor P2Y1 Rattus norvegicus 161-165 9831901-13 1998 A 1 u ml(-1) apyrase III solution generated 20 microM ADP from 0.1 mM ATP within 15 s. This concentration of ADP was sufficient to produce maximal activation of P2Y1 receptors. Adenosine Diphosphate 109-112 purinergic receptor P2Y1 Rattus norvegicus 161-165 9831901-21 1998 Results suggest that ATPDases prevent P2Y1 receptor activation by degrading ADP but may contribute to P2Y1 receptor activation by generating ADP from ATP. Adenosine Diphosphate 76-79 purinergic receptor P2Y1 Rattus norvegicus 38-42 9831901-21 1998 Results suggest that ATPDases prevent P2Y1 receptor activation by degrading ADP but may contribute to P2Y1 receptor activation by generating ADP from ATP. Adenosine Diphosphate 141-144 purinergic receptor P2Y1 Rattus norvegicus 38-42 9831901-21 1998 Results suggest that ATPDases prevent P2Y1 receptor activation by degrading ADP but may contribute to P2Y1 receptor activation by generating ADP from ATP. Adenosine Diphosphate 141-144 purinergic receptor P2Y1 Rattus norvegicus 102-106 9785476-0 1998 Phospholipase A2: its role in ADP- and thrombin-induced platelet activation mechanisms. Adenosine Diphosphate 30-33 phospholipase A2 group IB Homo sapiens 0-16 9785476-5 1998 However, the mechanism(s) of activation of PLA2 in platelets stimulated by ADP and thrombin has remained less well defined and much less appreciated. Adenosine Diphosphate 75-78 phospholipase A2 group IB Homo sapiens 43-47 9785476-6 1998 The purpose of this review is to examine and compare the molecular mechanisms of activation of PLA2 in platelets stimulated by ADP and thrombin. Adenosine Diphosphate 127-130 phospholipase A2 group IB Homo sapiens 95-99 9771898-1 1998 Possible involvement of the ATP/ADP antiporter and uncoupling protein (UCP) in thermoregulatory uncoupling of oxidative phosphorylation in heart muscle has been studied. Adenosine Diphosphate 32-35 uncoupling protein 1 Rattus norvegicus 71-74 9771898-9 1998 It is concluded that in heart muscle mitochondria the ATP/ADP antiporter is responsible for the "mild uncoupling" under normal conditions and for major portion of the thermoregulatory uncoupling in the cold whereas the rest of thermoregulatory uncoupling is served by UCP (presumably by UCP2 since the UCP2 mRNA level is shown to strongly increase in rat heart muscle under the cold exposure conditions used). Adenosine Diphosphate 58-61 uncoupling protein 1 Rattus norvegicus 268-271 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 36-57 fibrinogen beta chain Homo sapiens 81-91 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 36-57 fibrinogen beta chain Homo sapiens 198-208 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 81-91 9819001-2 1998 SR121566 dose-dependently inhibited adenosine diphosphate (ADP)-induced platelet fibrinogen binding determined either by flow cytometry analysis (IC50=50 nmol/l) or by measuring the binding of 125I-fibrinogen to activated human gel-filtered platelets (IC50=20 nmol/l). Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 198-208 9726229-7 1998 Physiological concentrations of MgADP (100 micromol/l) enhanced glibenclamide inhibition of Kir6.2/SUR1 currents but reduced that of Kir6.2/SUR2A currents. Adenosine Diphosphate 32-37 ATP-binding cassette sub-family C member 8 Xenopus laevis 99-103 9704012-0 1998 Extracellular ATP and ADP activate transcription factor NF-kappa B and induce endothelial cell apoptosis. Adenosine Diphosphate 22-25 nuclear factor kappa B subunit 1 Homo sapiens 56-66 9733156-1 1998 125I-fibrinogen bound to ADP-activated fixed platelets in a saturable manner. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 5-15 9704012-3 1998 ATP and ADP activated EC transcribed mRNA from certain transcription factor NF-kappa B target genes and expressed E-selectin protein on cell membranes. Adenosine Diphosphate 8-11 nuclear factor kappa B subunit 1 Homo sapiens 76-86 9704012-4 1998 Band shift analysis and reporter assays confirmed the activation of NF-kappa B in response to both ATP and ADP. Adenosine Diphosphate 107-110 nuclear factor kappa B subunit 1 Homo sapiens 68-78 9704012-6 1998 Induction of EC activation responses and apoptosis in response to stimulation with ATP and ADP is associated with activation of NF-kappa B. Adenosine Diphosphate 91-94 nuclear factor kappa B subunit 1 Homo sapiens 128-138 9665733-0 1998 Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase. Adenosine Diphosphate 24-27 G protein-coupled receptor kinase 7 Homo sapiens 86-102 9675277-9 1998 The presence of Gialpha1, Gialpha2, Gialpha3 and Goalpha in this apical membrane preparation was confirmed by PTX catalysed [32P]ADP-dependent ribosylation and Western blotting. Adenosine Diphosphate 129-132 guanine nucleotide-binding protein G(i) subunit alpha-3 Cavia porcellus 36-44 9767830-4 1998 NO SYNTHESIS: Nitric oxide is synthesized from L-arginine by NO-synthetase whose activity is regulated by intracellular calcium concentration and modulated by pharmacological compounds such as acetylcholine, 5-hydroxytryptamine, bradykinin and ADP as well as the sheer forces produced by blood flow. Adenosine Diphosphate 244-247 kininogen 1 Homo sapiens 229-239 9642211-3 1998 To determine whether each site can hydrolyze ATP simultaneously, we used an orthovanadate (Vi)-induced ADP-trapping technique (P-gp.MgADP.Vi). Adenosine Diphosphate 103-106 ATP binding cassette subfamily B member 1 Homo sapiens 127-131 9642211-3 1998 To determine whether each site can hydrolyze ATP simultaneously, we used an orthovanadate (Vi)-induced ADP-trapping technique (P-gp.MgADP.Vi). Adenosine Diphosphate 132-137 ATP binding cassette subfamily B member 1 Homo sapiens 127-131 9642211-4 1998 In analogy with other ATPases, a photochemical peptide bond cleavage reaction occurs within the Walker A nucleotide binding domain consensus sequence (GX4GK(T/S)) when the molecule is trapped with Vi in an inhibited catalytic transition state (P-gp.MgADP.Vi) and incubated in the presence of ultraviolet light. Adenosine Diphosphate 249-254 ATP binding cassette subfamily B member 1 Homo sapiens 244-248 9637652-7 1998 RESULTS: Agonist-induced platelet aggregation and fibrinogen binding were significantly greater at 22 degrees C and 33 degrees C than at 37 degrees C. Platelet fibrinogen binding values to 20 micro M ADP were 23,400, 14,300, and 9,700 molecules/platelet at 22 degrees C, 33 degrees C, and 37 degrees C, respectively. Adenosine Diphosphate 200-203 fibrinogen beta chain Homo sapiens 160-170 9609698-1 1998 Myosin subfragment-1 (S1) was labeled with NPM in the presence of ATP or with pPDM in the presence of ADP at 0 degreesC, conditions which favor linking of maleimide groups to both Cys-707 (SH1) and Cys-697 (SH2). Adenosine Diphosphate 102-105 proteasome 26S subunit, non-ATPase 1 Homo sapiens 0-24 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 139-149 9581870-19 1998 The reported binding of amino-terminal Src oligopeptide to p32 ADP/ATP carrier in the mitochondrial inner membrane raises the question of its possible involvement in mitochondria-regulated mineralization. Adenosine Diphosphate 63-66 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 39-42 9657446-11 1998 Endogenous ADP release and fibrinogen binding to alpha(IIb)beta3 are responsible for the synthesis of TXA2 which results in the induction of the second peak of [Ca2+]i in low thrombin- but not TRAP-stimulated platelets. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 175-183 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 24-34 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 139-149 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 24-34 9691771-5 1998 We converted a ratio of fibrinogen binding platelets to a velocity per unit concentration of ADP as follows: a difference of two ratios of fibrinogen binding platelets on neighboring two ADP concentrations was divided by a difference of ADP concentrations. Adenosine Diphosphate 187-190 fibrinogen beta chain Homo sapiens 139-149 9609236-5 1998 Infusion of RGDS or Ro-43-8857 into ADP-stimulated PRP completely prevented adhesion as well as subsequent aggregation. Adenosine Diphosphate 36-39 complement component 4 binding protein alpha Homo sapiens 51-54 9585537-4 1998 However, the D10 mutation completely abolished the effects of both ATP and ADP on peptide and clathrin binding. Adenosine Diphosphate 75-78 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion Homo sapiens 13-16 9588391-6 1998 The physiologic activators ADP and thrombin both supported efficient aggregation of washed platelets with no exogenous ligands at 1000 sec(-1) by surface-secreted vWF (CE = 0.08 +/- 0.01, n = 6), in contrast to poorer ADP and soluble Fg-mediated aggregation in the absence of secretion (CE = 0.05). Adenosine Diphosphate 27-30 von Willebrand factor Homo sapiens 163-166 9588391-6 1998 The physiologic activators ADP and thrombin both supported efficient aggregation of washed platelets with no exogenous ligands at 1000 sec(-1) by surface-secreted vWF (CE = 0.08 +/- 0.01, n = 6), in contrast to poorer ADP and soluble Fg-mediated aggregation in the absence of secretion (CE = 0.05). Adenosine Diphosphate 218-221 coagulation factor II, thrombin Homo sapiens 35-43 9588391-6 1998 The physiologic activators ADP and thrombin both supported efficient aggregation of washed platelets with no exogenous ligands at 1000 sec(-1) by surface-secreted vWF (CE = 0.08 +/- 0.01, n = 6), in contrast to poorer ADP and soluble Fg-mediated aggregation in the absence of secretion (CE = 0.05). Adenosine Diphosphate 218-221 von Willebrand factor Homo sapiens 163-166 9588391-1 1998 This article addresses the flow-dependent differential roles of the platelet receptors, glycoprotein (GP) GPIb and GPIIb-IIIa, in platelet aggregation mediated by ristocetin and soluble von Willebrand factor (vWF), by adenosine diphosphate (ADP) and soluble fibrinogen (Fg), and by thrombin and ADP in absence of exogenous ligands. Adenosine Diphosphate 218-239 von Willebrand factor Homo sapiens 209-212 9588391-1 1998 This article addresses the flow-dependent differential roles of the platelet receptors, glycoprotein (GP) GPIb and GPIIb-IIIa, in platelet aggregation mediated by ristocetin and soluble von Willebrand factor (vWF), by adenosine diphosphate (ADP) and soluble fibrinogen (Fg), and by thrombin and ADP in absence of exogenous ligands. Adenosine Diphosphate 241-244 von Willebrand factor Homo sapiens 209-212 9684758-7 1998 Results showed that the administration of fibrinogen increases the number of emboli, the duration of embolization, the amplitude, and the velocity of the ex-vivo platelet aggregation induced by ADP (p < 0.05). Adenosine Diphosphate 194-197 fibrinogen beta chain Homo sapiens 42-52 9588188-2 1998 However, the significance of these parallel signal transduction processes has not been clearly elucidated in the light of the prevalent autocrine stimulation in platelets: a great amplification of the thrombin signal through secreted ADP, by production of thromboxane A2 from the liberated arachidonic acid, by the close cell contact produced by aggregation caused by exposure of integrin receptors that become ligated by fibrinogen and other platelet-produced factors. Adenosine Diphosphate 234-237 coagulation factor II, thrombin Homo sapiens 201-209 9553060-3 1998 In the presence of vanadate and MgATP, a nucleotide (ADP) is trapped in MDR1, which alters the drug binding properties of the protein. Adenosine Diphosphate 53-56 ATP binding cassette subfamily B member 1 Homo sapiens 72-76 9538267-8 1998 Immunoprecipitation also revealed that the 18.1 kDa protein formed a complex with the 21.9 kDa protein and the 45 kDa protein with mHsp70; the latter complex was dissociated in an ATP- or ADP-dependent manner and the reaction was impeded by AMP-PNP or inorganic phosphate. Adenosine Diphosphate 188-191 heat shock protein 1B Mus musculus 131-137 9556521-8 1998 Interestingly, the more physiologically relevant "low affinity" nucleotide-bound ((ATP/ADP) GroEL--GroES) complex is not as efficient at capturing the initial folding intermediates of glutamine synthetase. Adenosine Diphosphate 87-90 GroEL Escherichia coli 92-97 9538020-8 1998 Vanadate which is known to inhibit ATPase activity by trapping MgADP at the catalytic site inhibited photoaffinity labeling of Pgp with substrate analogues, [125I]iodoarylazidoprazosin and [3H]azidopine, only under ATP hydrolysis conditions. Adenosine Diphosphate 63-68 ATP binding cassette subfamily B member 1 Homo sapiens 127-130 9538020-9 1998 Because vanadate-trapped Pgp is known to resemble the ADP and phosphate-bound catalytic transition state, our findings indicate that ATP hydrolysis results in a conformation with reduced affinity for substrates. Adenosine Diphosphate 54-57 ATP binding cassette subfamily B member 1 Homo sapiens 25-28 9529092-10 1998 Additionally, cotreatment of RAW cells with the potent inflammatory mediator ADP had no effect on the ability of R. capsulatus LPS to stimulate NO production but significantly enhanced induction of NO production by the toxic species of LPS. Adenosine Diphosphate 77-80 toll-like receptor 4 Mus musculus 236-239 9516436-9 1998 However, the sequence of addition of poly(rU) to a diluted solution of ADP/NaF-treated enzyme had a profound effect on the extent of inhibition. Adenosine Diphosphate 71-74 C-X-C motif chemokine ligand 8 Homo sapiens 75-78 9545001-14 1998 IGF-I and IGF-BP3 increment on dP (and sustained on adP) is possibly due to liver regeneration, in contrast with inhibition of body growth on dP, possibly due to central and peripheral effects of corticosteroid. Adenosine Diphosphate 52-55 insulin like growth factor 1 Homo sapiens 0-5 9516436-10 1998 If the ADP/NaF-treated enzyme was diluted into an assay that lacked poly(rU) and the assay was subsequently initiated with poly(rU), the treated enzyme was not inhibited. Adenosine Diphosphate 7-10 C-X-C motif chemokine ligand 8 Homo sapiens 11-14 9516436-12 1998 ATP protected the enzyme from inhibition by ADP/NaF. Adenosine Diphosphate 44-47 C-X-C motif chemokine ligand 8 Homo sapiens 48-51 9516436-13 1998 The stoichiometry between ADP and enzyme monomer in the inhibited enzyme complex was 2, as determined from titration of the ATPase activity ([ADP]/[E] = 2.2) and from the number of radiolabeled ADP bound to the inhibited enzyme ([ADP]/[E] = 1.7) in the presence of excess NaF, MgCl2, and poly(rU). Adenosine Diphosphate 26-29 C-X-C motif chemokine ligand 8 Homo sapiens 272-275 9516436-15 1998 The stoichiometry between (dU)18, a defined oligomeric nucleic acid substituting for poly(rU), and enzyme monomer in the inhibited enzyme complex was estimated to be 1 ([(dU)18/[E] = 1.2) from titration of the ATPase activity in the presence of excess ADP, MgCl2, and NaF. Adenosine Diphosphate 252-255 C-X-C motif chemokine ligand 8 Homo sapiens 268-271 9501222-3 1998 We observed that platelets obtained from mice in which the P-12LO gene has been disrupted by gene targeting (P-12LO-/-) exhibit a selective hypersensitivity to ADP, manifested as a marked increase in slope and percent aggregation in ex vivo assays and increased mortality in an ADP-induced mouse model of thromboembolism. Adenosine Diphosphate 160-163 arachidonate 12-lipoxygenase Mus musculus 59-65 9501222-3 1998 We observed that platelets obtained from mice in which the P-12LO gene has been disrupted by gene targeting (P-12LO-/-) exhibit a selective hypersensitivity to ADP, manifested as a marked increase in slope and percent aggregation in ex vivo assays and increased mortality in an ADP-induced mouse model of thromboembolism. Adenosine Diphosphate 160-163 arachidonate 12-lipoxygenase Mus musculus 109-115 9501222-3 1998 We observed that platelets obtained from mice in which the P-12LO gene has been disrupted by gene targeting (P-12LO-/-) exhibit a selective hypersensitivity to ADP, manifested as a marked increase in slope and percent aggregation in ex vivo assays and increased mortality in an ADP-induced mouse model of thromboembolism. Adenosine Diphosphate 278-281 arachidonate 12-lipoxygenase Mus musculus 59-65 9501222-3 1998 We observed that platelets obtained from mice in which the P-12LO gene has been disrupted by gene targeting (P-12LO-/-) exhibit a selective hypersensitivity to ADP, manifested as a marked increase in slope and percent aggregation in ex vivo assays and increased mortality in an ADP-induced mouse model of thromboembolism. Adenosine Diphosphate 278-281 arachidonate 12-lipoxygenase Mus musculus 109-115 9501222-5 1998 The addition of 12-hydroxyeicosatetraenoic acid to P-12LO-/- platelet-rich plasma rescues the hyperresponsive phenotype resulting in a diminished ADP-induced aggregation profile. Adenosine Diphosphate 146-149 arachidonate 12-lipoxygenase Mus musculus 51-57 9501222-6 1998 The enhanced ADP sensitivity of P-12LO-/- mice appears to reveal a mechanism by which a product of the P-12LO pathway suppresses platelet activation by ADP. Adenosine Diphosphate 13-16 arachidonate 12-lipoxygenase Mus musculus 32-38 9501222-6 1998 The enhanced ADP sensitivity of P-12LO-/- mice appears to reveal a mechanism by which a product of the P-12LO pathway suppresses platelet activation by ADP. Adenosine Diphosphate 13-16 arachidonate 12-lipoxygenase Mus musculus 103-109 9501222-6 1998 The enhanced ADP sensitivity of P-12LO-/- mice appears to reveal a mechanism by which a product of the P-12LO pathway suppresses platelet activation by ADP. Adenosine Diphosphate 152-155 arachidonate 12-lipoxygenase Mus musculus 32-38 9501222-6 1998 The enhanced ADP sensitivity of P-12LO-/- mice appears to reveal a mechanism by which a product of the P-12LO pathway suppresses platelet activation by ADP. Adenosine Diphosphate 152-155 arachidonate 12-lipoxygenase Mus musculus 103-109 9435321-5 1998 In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 136-146 9563821-4 1998 BAG-1 acts as a nucleotide exchange factor in the Hsc70 ATPase cycle, thereby competing with the cofactor Hip which stabilizes the ADP-bound state of Hsc70. Adenosine Diphosphate 131-134 BAG cochaperone 1 Homo sapiens 0-5 9485302-0 1998 X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. Adenosine Diphosphate 73-76 Kar3p Saccharomyces cerevisiae S288C 37-41 9485302-9 1998 We now report the structure of the Kar3 protein complexed with Mg.ADP obtained from crystallographic data to 2.3 A. Adenosine Diphosphate 66-69 Kar3p Saccharomyces cerevisiae S288C 35-39 9480829-2 1998 We investigated the possible role of reactions of ADP-ribosylation in triggering the signaling pathways involved in NOS-II gene expression. Adenosine Diphosphate 50-53 nitric oxide synthase 2, inducible Mus musculus 116-122 9534008-6 1998 These results support the notion that variations in the ATP/ADP ratio are sufficient to induce pulsatile insulin release. Adenosine Diphosphate 60-63 insulin Homo sapiens 105-112 9435321-5 1998 In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Adenosine Diphosphate 97-100 von Willebrand factor Homo sapiens 197-200 9885366-7 1998 Fibrinogen treated with high doses of MB (50 microM) showed a weaker binding to the fibrinogen receptor (GP IIb/IIIa) on the platelet surface and a decrease in platelet aggregation after stimulation with ADP and photooxidized fibrinogen. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 0-10 9832332-5 1998 In contrast, botulinum toxin C, which mediates the ADP ribosylation of a 21 kD ras-related G protein, augmented IL-1beta-induced GMCSF mRNA expression. Adenosine Diphosphate 51-54 interleukin 1 beta Homo sapiens 112-120 9414275-14 1998 Our results suggest that ATP/ADP can induce vWF release from endothelial cells via dual activation of P2y and adenosine A2 receptors. Adenosine Diphosphate 29-32 von Willebrand factor Homo sapiens 44-47 9839547-1 1998 The binding of insulin in physiological amounts to human blood platelets, which increases adenylate cyclase-linked prostacyclin receptor numbers on the cell surface, was found to be directly related to the ADP-ribosylation of the Gi alpha. Adenosine Diphosphate 206-209 insulin Homo sapiens 15-22 9519806-11 1998 IAP and CTX-catalyzed ADP ribosylation assays confirmed that SAGP augmented the activity of IAP-sensitive G-protein. Adenosine Diphosphate 22-25 intracisternal A particle, Eya1 linked Mus musculus 92-95 16793705-5 1998 Adding the chemotactic peptide FM LP, which stimulates neutrophils and monocytes but not lymphocytes and platelets, to stirred whole blood samples resulted in a significant enhancement ( P < 0.01) of spontaneous as well as ADP-induced platelet aggregation (25 vs 33% and 66 vs 69% , respectively). Adenosine Diphosphate 226-229 formyl peptide receptor 1 Homo sapiens 31-36 9396736-9 1997 We found that generation of tryptic fragments, including the loop linking transmembrane (TM) regions TM8 and TM9 of Pgp, were stimulated by the binding of Mg-p[NH]ppA, MgATP and MgADP, indicating that the Pgp conformation was changed by the binding of these nucleotides. Adenosine Diphosphate 178-183 ATP binding cassette subfamily B member 1 Homo sapiens 116-119 9787410-4 1998 In vitro incubation of human platelet-rich plasma (PRP) with PAEC inhibited platelet aggregation induced by ADP, collagen and arachidonic acid in a time-dependent manner and partially inhibited adrenalin-induced aggregation. Adenosine Diphosphate 108-111 complement component 4 binding protein alpha Homo sapiens 51-54 9396736-9 1997 We found that generation of tryptic fragments, including the loop linking transmembrane (TM) regions TM8 and TM9 of Pgp, were stimulated by the binding of Mg-p[NH]ppA, MgATP and MgADP, indicating that the Pgp conformation was changed by the binding of these nucleotides. Adenosine Diphosphate 178-183 ATP binding cassette subfamily B member 1 Homo sapiens 205-208 9435622-2 1997 Ceruloplasmin at physiological, i.e., micromolar, concentrations inhibited relaxation of rabbit aorta induced by endothelium-dependent agonists like acetylcholine or ADP, whereas it was ineffective toward vasodilation due to direct stimulation of smooth muscle cells by nitroglycerin. Adenosine Diphosphate 166-169 ceruloplasmin Oryctolagus cuniculus 0-13 9395189-4 1997 Not only in samples from thrombocytopenic persons but also with normal platelet count, increasing amounts of ATP were released with increasing ADP concentrations, finally exceeding the ATP releasable from thrombocytes by thrombin. Adenosine Diphosphate 143-146 coagulation factor II, thrombin Homo sapiens 221-229 9395189-5 1997 The amounts of ADP required to match the ATP release of thrombin were closely correlated with the platelet counts in the samples. Adenosine Diphosphate 15-18 coagulation factor II, thrombin Homo sapiens 56-64 9341138-4 1997 In this report, the binding of GroES to highly purified GroEL in the presence of ATP, ADP, and the nonhydrolyzable ATP analogue, 5"-adenylyl beta,gamma-imidodiphosphate (AMP-PNP), was investigated by using the fluorescence anisotropy of succinimidyl-1-pyrenebutyrate-labeled GroES. Adenosine Diphosphate 86-89 GroEL Escherichia coli 56-61 9523019-1 1997 The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 56-66 9408022-7 1997 Furthermore, LM-PLA2 displayed a moderate inhibitory activity on the aggregation of rabbit platelets induced by low levels of ADP, thrombin and arachidonate. Adenosine Diphosphate 126-129 phospholipase A2, group V Mus musculus 16-20 9341138-6 1997 In contrast, in the presence of ADP or AMP-PNP only one molecule of oligomeric GroES can be tightly bound by GroEL. Adenosine Diphosphate 32-35 GroEL Escherichia coli 109-114 9341138-8 1997 In the presence of ADP alone, a second GroES ring can bind to GroEL weakly and with negative cooperativity. Adenosine Diphosphate 19-22 GroEL Escherichia coli 62-67 9351802-1 1997 The structure of the molecular chaperone GroEL from Escherichia coli in complex with GroES and seven ADP molecules has recently been reported to 3 A resolution. Adenosine Diphosphate 101-104 GroEL Escherichia coli 41-46 9321400-5 1997 Similar to the action of the GrpE protein on bacterial Hsp70, BAG-1 accelerates the release of ADP from Hsc70. Adenosine Diphosphate 95-98 BAG cochaperone 1 Homo sapiens 62-67 9321400-6 1997 Thus, BAG-1 regulates the Hsc70 ATPase in a manner contrary to the Hsc70-interacting protein Hip, which stabilizes the ADP-bound state. Adenosine Diphosphate 119-122 BAG cochaperone 1 Homo sapiens 6-11 9350615-14 1997 When SUR1 was mutated to abolish MgADP activation of KATP currents (K719A or K1384M), there was no difference in the extent of tolbutamide inhibition in the presence or absence of MgADP. Adenosine Diphosphate 33-38 ATP-binding cassette sub-family C member 8 Xenopus laevis 5-9 9363787-7 1997 On the other hand, modification of G(s alpha) by cholera toxin, which catalyses ADP-ribosylation of Arg201 of G(s alpha), decreased the rates of hydrolysis of both GTP and its analog by 95%. Adenosine Diphosphate 80-83 GNAS complex locus Homo sapiens 35-44 9363787-7 1997 On the other hand, modification of G(s alpha) by cholera toxin, which catalyses ADP-ribosylation of Arg201 of G(s alpha), decreased the rates of hydrolysis of both GTP and its analog by 95%. Adenosine Diphosphate 80-83 GNAS complex locus Homo sapiens 110-119 9350615-21 1997 Our results indicate that interaction of tolbutamide with the high-affinity site (on SUR1) abolishes the stimulatory action of MgADP. Adenosine Diphosphate 127-132 ATP-binding cassette sub-family C member 8 Xenopus laevis 85-89 9223456-5 1997 The potency order for the induction of fMLP-stimulated beta-glucuronidase release by adenine nucleotides and adenosine was ATPgammaS > or = ATP > ADP > AMP = Adenosine approximately 0. Adenosine Diphosphate 152-155 formyl peptide receptor 1 Homo sapiens 39-43 9366273-2 1997 To our knowledge, it is the most potent inhibitor known for CK: the Ki value versus ADP was 330 nM and 110 nM for CK-MM and BB respectively. Adenosine Diphosphate 84-87 creatine kinase, M-type Homo sapiens 114-119 9387093-2 1997 Drawing on the hexokinase-mitochondrial acceptor theory of insulin action, this article presents evidence suggesting that the increased binding of hexokinase to porin on mitochondria of cancer cells not only accelerates glycolysis by providing hexokinase with better access to ATP, but also stimulates the TCA cycle by providing the mitochondrion with ADP that acts as an acceptor for phosphoryl groups. Adenosine Diphosphate 352-355 hexokinase 1 Homo sapiens 147-157 9387093-2 1997 Drawing on the hexokinase-mitochondrial acceptor theory of insulin action, this article presents evidence suggesting that the increased binding of hexokinase to porin on mitochondria of cancer cells not only accelerates glycolysis by providing hexokinase with better access to ATP, but also stimulates the TCA cycle by providing the mitochondrion with ADP that acts as an acceptor for phosphoryl groups. Adenosine Diphosphate 352-355 hexokinase 1 Homo sapiens 147-157 9268194-5 1997 Stimulation of platelets with thrombin, ADP or epinephrine causes a partial translocation of dynein from the soluble fraction to the particulate fraction with thrombin being the most efficient agent at promoting this shift. Adenosine Diphosphate 40-43 coagulation factor II, thrombin Homo sapiens 159-167 9364994-5 1997 Platelet aggregation in response to ADP was found to be inhibited after preincubation with TNF-alpha in non-pregnant (38%, p = 0.01) and in normal pregnant women (54%, p = 0.001) and not affected in pre-eclamptic women. Adenosine Diphosphate 36-39 tumor necrosis factor Homo sapiens 91-100 9285585-4 1997 The structure of the GroEL-GroES-(ADP)7 complex reveals how large en bloc movements of the cis ring"s intermediate and apical domains enable bound GroES to stabilize a folding chamber with ADP confined to the cis ring. Adenosine Diphosphate 34-37 GroEL Escherichia coli 21-26 9237625-1 1997 CFTR-NBF-2 expressed and purified in fusion with the maltose-binding protein was shown to catalyse the reaction ATP-->ADP+Pi by three different assays, monitoring ATP turnover, formation of ADP and release of Pi (Km 86 microM, rate constant 0.37 min(-1)). Adenosine Diphosphate 121-124 CF transmembrane conductance regulator Homo sapiens 0-4 9247708-9 1997 It has been suggested that aldolase and GPDH form a 1:1 complex of dissociation constant equal to or less than 5 x 10(-8) M. The complex was found to dissociate in the presence of KCl, (NH4)2SO4, ATP and NADH whereas its formation was favoured by fructose-1,6-bisphosphate, glyceraldehyde-3-phosphate, NAD+, ADP, AMP and phosphate ions. Adenosine Diphosphate 308-311 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 40-44 9352095-6 1997 The percentage of ADP-induced platelet aggregation decreased as a function of fibrinogen oxidative damage. Adenosine Diphosphate 18-21 fibrinogen beta chain Homo sapiens 78-88 9237625-1 1997 CFTR-NBF-2 expressed and purified in fusion with the maltose-binding protein was shown to catalyse the reaction ATP-->ADP+Pi by three different assays, monitoring ATP turnover, formation of ADP and release of Pi (Km 86 microM, rate constant 0.37 min(-1)). Adenosine Diphosphate 193-196 CF transmembrane conductance regulator Homo sapiens 0-4 9354374-7 1997 In addition, we found that basal and glyceraldehyde-3-phosphate-induced modifications of GAPDH, both of which have also been explained as ADP-ribosylation, were not ADP-ribosylation, and that the modification of GAPDH in the absence and presence of NO or GA3P was distinct in the dithiothreitol effect or resistance to HgCl2. Adenosine Diphosphate 138-141 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 89-94 9207394-3 1997 Preincubation with thrombopoietin significantly enhanced platelet aggregation stimulated by ADP, collagen, or epinephrine in the MPD group as well as the control group. Adenosine Diphosphate 92-95 thrombopoietin Homo sapiens 19-33 9207394-4 1997 However, aggregation induced by 3 micro ADP or 16 microM epinephrine showed significantly less augmentation by thrombopoietin in the MPD group than in the control group. Adenosine Diphosphate 40-43 thrombopoietin Homo sapiens 111-125 9207394-5 1997 Thrombopoietin significantly shortened the lag time between the addition of 3 microM ADP or 16 microM epinephrine and initiation of secondary aggregation and the lag time between addition of 2 microg/ml collagen and initiation of aggregation in both groups. Adenosine Diphosphate 85-88 thrombopoietin Homo sapiens 0-14 9354374-2 1997 Though this notion is based on the finding that NO increases the auto-ADP-ribosylation of GAPDH, controversial data have also been reported. Adenosine Diphosphate 70-73 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 90-95 9354374-4 1997 GAPDH was modified equally with [adenosine-14C]NAD+ and [carbonyl-14C]NAD+, indicating that the glycoside bond of NAD+ between ADP-ribose and nicotinamide is intact. Adenosine Diphosphate 127-130 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 0-5 9264319-4 1997 AP155 was able to inhibit aggregation, the increase in cytosolic Ca++ induced by thrombin, and fibrinogen binding to ADP or thrombin-stimulated platelets. Adenosine Diphosphate 117-120 fibrinogen beta chain Homo sapiens 95-105 9139695-7 1997 The GroEL/ES-bound native GFP was observed only when both GroES and ATP (but not ADP) were present in the folding mixture. Adenosine Diphosphate 81-84 GroEL Escherichia coli 4-9 9108793-2 1997 Like platelets, CMK 11-5 cells responded with an increase in intracellular Ca2+ mobilization in response to ADP but not to ATP or adenosine. Adenosine Diphosphate 108-111 C-X-C motif chemokine ligand 9 Homo sapiens 16-19 9179586-5 1997 8-(p-Sulfophenyl)-theophylline, a blocker of adenosine receptors, suppressed the enhanced NO production by adenosine and ADP to the level of that with IL-1 beta alone. Adenosine Diphosphate 121-124 interleukin 1 beta Rattus norvegicus 151-160 9139798-0 1997 Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5"-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*. Adenosine Diphosphate 74-98 GNAS complex locus Homo sapiens 149-157 9139798-0 1997 Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5"-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*. Adenosine Diphosphate 100-103 GNAS complex locus Homo sapiens 149-157 9139798-0 1997 Luteinizing hormone/choriogonadotropin-dependent, cholera toxin-catalyzed adenosine 5"-diphosphate (ADP)-ribosylation of the long and short forms of Gs alpha and pertussis toxin-catalyzed ADP-ribosylation of Gi alpha*. Adenosine Diphosphate 188-191 GNAS complex locus Homo sapiens 149-157 9108100-5 1997 When tested for their inhibitory effects on platelet aggregation by ADP, the most promising agent among them was Ap(s)pCHClpp(s)A. Adenosine Diphosphate 68-71 dacapo Drosophila melanogaster 113-115 9108100-7 1997 This agent inhibits a number of aspects of ADP-induced platelet activation-e.g., release reaction, cytoplasmic calcium mobilization, thromboxane production, fibrinogen binding sites, and platelet factor 3 activity. Adenosine Diphosphate 43-46 dacapo Drosophila melanogaster 5-6 9142866-1 1997 Experiments that used dispersed salivary gland cells from 1-day-old rats indicated the presence of the P2Y nucleotide receptor subtype, P2Y1, based on the agonist potency profile for mobilization of intracellular free Ca2+ [2-methylthio-ATP > ADP > adenosine 5"-O-(2-thiodiphosphate) > ATP, with UTP ineffective] and sequence analysis of reverse transcription-polymerase chain reaction (RT-PCR) products obtained with P2Y1 receptor-specific primers. Adenosine Diphosphate 246-249 purinergic receptor P2Y1 Rattus norvegicus 136-140 9139977-9 1997 The structure-function cascade of intra-LM ATP and its analogs was alpha,beta-mATP > 2-MeSATP > ATP > or = beta,gamma-mATP > ADP >> AMP = 0. Adenosine Diphosphate 137-140 solute carrier family 45, member 2 Mus musculus 127-131 9168979-3 1997 This antibody inhibited high shear-induced platelet aggregation and blocked adhesion of ADP plus epinephrine-stimulated platelets to vWf, indicating that it interferes with the interaction with alpha IIb beta 3. Adenosine Diphosphate 88-91 von Willebrand factor Homo sapiens 133-136 9143365-3 1997 With MgATP or MgADP, reactivation occurred with t1/2 = 7 min at 37 degrees C. With 8-azido-ATP, UV irradiation of inhibited Pgp gave specific photolabeling of both nucleotide sites. Adenosine Diphosphate 14-19 ATP binding cassette subfamily B member 1 Homo sapiens 124-127 9154904-10 1997 The NO3- effect was compatible with competitive binding of NO3- and ADP in addition to the general I-effect. Adenosine Diphosphate 68-71 NBL1, DAN family BMP antagonist Homo sapiens 4-7 9168936-7 1997 Flow cytometric analysis revealed that platelets stimulated with 10 mumol/L ADP at 108 dyne/cm2 bound fluorescein isothiocyanate (FITC)-labeled fibrinogen, although aggregation was absent in this experimental condition. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 144-154 9108793-4 1997 Pharmacological responsiveness of CMK 11-5 cells to nucleotides paralleled those of platelets, in which ADP and ADP-alpha-S are active as agonists and ATP and ATP-alpha-S are inactive as agonists but act as antagonists. Adenosine Diphosphate 104-107 C-X-C motif chemokine ligand 9 Homo sapiens 34-37 9108793-5 1997 [3H]ADP and 35S-ATP-alpha-S bound to CMK 11-5 cells at a high-affinity site (Kd1 and Ki1, 262 and 125 nmol/L, respectively) and a low-affinity site (Kd2 and Ki2, 10,100 and 5400 nmol/L, respectively) with 2 x 10(6) to 6 x 10(6) sites per cell. Adenosine Diphosphate 4-7 C-X-C motif chemokine ligand 9 Homo sapiens 37-40 9108793-6 1997 ADP bound at both sites was competed with ADP, ATP, and ATP-alpha-S with affinities in a rank order similar to that found for platelets (ATP-alpha-S approximately ATP approximately ADP > or = ADP-beta-S approximately adenosine), suggesting the presence of a P2T receptor on CMK 11-5 cells. Adenosine Diphosphate 0-3 C-X-C motif chemokine ligand 9 Homo sapiens 277-280 9108793-8 1997 After RNA from CMK 11-5 cells was microinjected into Xenopus oocytes, only ADP and ADP-alpha-S stimulated 45Ca2+ efflux, which was not observed with ATP, 2-methylthio-ATP, alpha, beta-methylene-ATP, ATP-gamma-S, ATP-alpha-S, or adenosine. Adenosine Diphosphate 75-78 C-X-C motif chemokine ligand 9 Homo sapiens 15-18 9108300-3 1997 Mg2+ and K+ ions stabilize while ADP destabilizes the GroEL molecule against the action of temperature. Adenosine Diphosphate 33-36 GroEL Escherichia coli 54-59 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 146-149 fibroblast growth factor 2 Homo sapiens 37-42 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 146-149 fibroblast growth factor 2 Homo sapiens 162-167 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 146-149 fibroblast growth factor 2 Homo sapiens 162-167 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 249-252 fibroblast growth factor 2 Homo sapiens 37-42 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 249-252 fibroblast growth factor 2 Homo sapiens 162-167 9173879-3 1997 Incubation of transformed cells with FGF-2 and [adenylate-32P]nicotinamide-adenine dinucleotide (NAD) resulted in the rapid incorporation of [32P]ADP-ribose into FGF-2 in a time- and concentration-dependent manner, with labelling averaging 3 mol of ADP-ribose/mol of FGF-2. Adenosine Diphosphate 249-252 fibroblast growth factor 2 Homo sapiens 162-167 9173879-4 1997 Excess ADP-ribose had no effect on these reactions, whereas excess NAD inhibited the ADP-ribosylation of FGF-2, consistent with an enzymic rather than a non-enzymic ADP-ribosylation reaction. Adenosine Diphosphate 85-88 fibroblast growth factor 2 Homo sapiens 105-110 9173879-7 1997 These results identify the cell-surface ADP-ribosylation of FGF-2 as a potentially ubiquitous event. Adenosine Diphosphate 40-43 fibroblast growth factor 2 Homo sapiens 60-65 9151047-11 1997 Studying the platelet function, a statistically significant (P < 0.01) better preserved ADP- and collagen-induced platelet aggregation was seen in the r-hirudin/aprotinin-treated animals when compared with heparin/aprotinin-treated animals. Adenosine Diphosphate 91-94 pancreatic trypsin inhibitor-like Sus scrofa 164-173 9173879-2 1997 Further characterization of this reaction with cells expressing an arginine-specific, glycosylphosphatidylinositol-anchored, mono-ADP-ribosyltransferase demonstrated that FGF-2 is ADP-ribosylated on arginine. Adenosine Diphosphate 130-133 fibroblast growth factor 2 Homo sapiens 171-176 9108300-4 1997 Furthermore, ADP essentially increases the number of binding sites for the hydrophobic probe (ANS) and the number of GroEL SH-groups accessible to Ellman"s reagent as well as the accessibility of the protein to the action of trypsin. Adenosine Diphosphate 13-16 GroEL Escherichia coli 117-122 9108300-5 1997 The interaction of GroEL with GroES in the presence of Mg2+-ADP eliminates the destabilizing effect of ADP on the GroEL molecule against the action of temperature and Ellman"s reagent but does not change its hydrophobicity and accessibility to trypsin. Adenosine Diphosphate 60-63 GroEL Escherichia coli 19-24 9108300-5 1997 The interaction of GroEL with GroES in the presence of Mg2+-ADP eliminates the destabilizing effect of ADP on the GroEL molecule against the action of temperature and Ellman"s reagent but does not change its hydrophobicity and accessibility to trypsin. Adenosine Diphosphate 60-63 GroEL Escherichia coli 114-119 9126325-5 1997 The potency order for the induction of fMLP-stimulated beta-glucuronidase release by adenine nucleotides and adenosine was ATP gamma S > 3 ATP > ADP > AMP = Adenosine approximately 0. Adenosine Diphosphate 151-154 formyl peptide receptor 1 Homo sapiens 39-43 9122182-8 1997 The PARP coactivator function is suppressed by NAD+, probably as a result of auto-ADP-ribosylation. Adenosine Diphosphate 82-85 poly(ADP-ribose) polymerase 1 Homo sapiens 4-8 9118999-5 1997 ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes. Adenosine Diphosphate 30-33 NBL1, DAN family BMP antagonist Homo sapiens 67-70 9118999-5 1997 ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes. Adenosine Diphosphate 30-33 NBL1, DAN family BMP antagonist Homo sapiens 274-277 9118999-5 1997 ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes. Adenosine Diphosphate 229-232 NBL1, DAN family BMP antagonist Homo sapiens 67-70 9212358-5 1997 Platelet aggregation following addition of 20 muM ADP to PC, obtained from 12 single donors, resulted in an average maximal light transmission (light transmission/age of concentrate in days) of 61%/1 day and 37%/5 days, respectively. Adenosine Diphosphate 50-53 latexin Homo sapiens 46-49 9118999-5 1997 ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes. Adenosine Diphosphate 229-232 NBL1, DAN family BMP antagonist Homo sapiens 67-70 9118999-5 1997 ATP binding to AK (as well as ADP-binding to AK in the presence of NO3-) induced protonation of a carboxylate group of Asp or Glu, as evidenced by the appearance of the 1733-cm(-1) band, which was not observed with the AK x Mg x ADP, AK x Mg x ADP x Arg and AK x Mg x ADP x NO3- x Arg complexes. Adenosine Diphosphate 229-232 NBL1, DAN family BMP antagonist Homo sapiens 67-70 9118999-6 1997 The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg). Adenosine Diphosphate 26-29 NBL1, DAN family BMP antagonist Homo sapiens 32-35 9118999-6 1997 The RIDS of the AK x Mg x ADP x NO3- x Arg complex showed new infrared bands at 1622 cm(-1) (negative) and at 1613 cm(-1) (positive), which were not seen in the RIDS of other complexes (without NO3- or/and Arg). Adenosine Diphosphate 26-29 NBL1, DAN family BMP antagonist Homo sapiens 194-197 9045820-5 1997 Under linear velocity conditions, N223-53 catalyzed the FAS (for factor activating exoenzyme S)-dependent ADP-ribosylation of soybean trypsin inhibitor (SBTI) at 0.4% and of the Ras protein at 1.0% of the rates of catalysis by N222-49. Adenosine Diphosphate 106-109 kunitz trypsin protease inhibitor Glycine max 134-151 9041562-4 1997 In purified GAPDH (37-kDa protein), SNP- and SNAP-induced enhancement of [32P]ADP-ribosylation, and inhibition of GAPDH activity. Adenosine Diphosphate 78-81 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 12-17 9038223-7 1997 2) When platelets were activated by ADP or a thromboxane analog, thrombin receptors that were initially in the surface connecting system were exposed on the platelet surface, increasing the number of detectable receptors by 40% and presumably making them available for subsequent activation by thrombin. Adenosine Diphosphate 36-39 coagulation factor II, thrombin Homo sapiens 65-73 9066012-0 1997 Surface-secreted von Willebrand factor mediates aggregation of ADP-activated platelets at moderate shear stress: facilitated by GPIb but controlled by GPIIb-IIIa. Adenosine Diphosphate 63-66 von Willebrand factor Homo sapiens 17-38 9066012-7 1997 We showed that mAbs 6D1 and NMC4, respectively blocking the adhesive domains on the GPIb receptor recognizing vWF, and on the vWF molecule recognizing the GPIb receptor, partially inhibited ADP-induced aggregation under shear in Couette flow, the degree of inhibition increasing with increasing shear stress. Adenosine Diphosphate 190-193 von Willebrand factor Homo sapiens 110-113 9066012-7 1997 We showed that mAbs 6D1 and NMC4, respectively blocking the adhesive domains on the GPIb receptor recognizing vWF, and on the vWF molecule recognizing the GPIb receptor, partially inhibited ADP-induced aggregation under shear in Couette flow, the degree of inhibition increasing with increasing shear stress. Adenosine Diphosphate 190-193 von Willebrand factor Homo sapiens 126-129 9038223-7 1997 2) When platelets were activated by ADP or a thromboxane analog, thrombin receptors that were initially in the surface connecting system were exposed on the platelet surface, increasing the number of detectable receptors by 40% and presumably making them available for subsequent activation by thrombin. Adenosine Diphosphate 36-39 coagulation factor II, thrombin Homo sapiens 294-302 9066012-9 1997 We conclude that vWF, expressed on ADP-activated platelets, is at least the predominant cross-bridging molecule mediating aggregation at moderate shear stress. Adenosine Diphosphate 35-38 von Willebrand factor Homo sapiens 17-20 9157599-3 1997 Pre-incubation of SPD-HPS and normal platelets with 0.005-5 microM ADP produced a dose-dependent inhibition of the [Ca2+]i response induced by 10 microM ADP, but did not alter the [Ca2+]i increases induced by thrombin or U46619. Adenosine Diphosphate 67-70 coagulation factor II, thrombin Homo sapiens 209-217 9029013-9 1997 Moreover, the signals generated by CD9 and PTA1 antigens differed significantly in their sensitivity to PKC inhibition or ADP-ribosylation of the small GTP-binding protein rhoA. Adenosine Diphosphate 122-125 ras homolog family member A Homo sapiens 172-176 9030542-2 1997 Reversible ADP-induced aggregation was accompanied by a reversible reorganization of the cytoskeleton and an increase in levels of the regulatory subunit p85alpha in this cytoskeleton similar to the increase observed in thrombin-activated platelets. Adenosine Diphosphate 11-14 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 154-162 9030542-2 1997 Reversible ADP-induced aggregation was accompanied by a reversible reorganization of the cytoskeleton and an increase in levels of the regulatory subunit p85alpha in this cytoskeleton similar to the increase observed in thrombin-activated platelets. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 220-228 9030542-5 1997 Moreover, in contrast to the situation for thrombin stimulation, the GTP-binding protein RhoA was hardly translocated to the cytoskeleton when platelets were stimulated with ADP, whereas translocation of pp60(c-)src and focal adhesion kinase did occur. Adenosine Diphosphate 174-177 ras homolog family member A Homo sapiens 89-93 9030542-6 1997 These results suggest (i) translocation of signaling enzymes does not necessarily imply their activation, (ii) the reversibility of ADP-induced platelet aggregation may be the cause or the result of a lack of PI 3-kinase activation and hence of PtdIns(3,4)P2 production, and (iii) RhoA does not seem to be involved in the ADP activation pathway of platelets. Adenosine Diphosphate 132-135 ras homolog family member A Homo sapiens 281-285 9030741-4 1997 When platelets were stimulated by thrombin, A23187 or ADP, APP-I was expressed on the platelet surface. Adenosine Diphosphate 54-57 amyloid beta precursor protein Homo sapiens 59-64 8995232-3 1997 Here we show that purified apoE (10-50 microg/ml), complexed with phospholipid vesicles (dimyristoylphosphatidylcholine, DMPC), suppresses platelet aggregation induced by ADP, epinephrine, or collagen. Adenosine Diphosphate 171-174 apolipoprotein E Homo sapiens 27-31 8994427-6 1997 In addition, fibrinogen binding and P-selectin expression were measured in response to ex vivo stimulation with the agonists ADP and thrombin. Adenosine Diphosphate 125-128 fibrinogen beta chain Homo sapiens 13-23 9030749-3 1997 Collisionally induced dissociation (CID)-MS and CID-MS-MS showed that the adenosine diphosphate part of the cofactor interacts strongly with AR. Adenosine Diphosphate 74-95 aldo-keto reductase family 1 member B Homo sapiens 141-143 8995232-6 1997 Thus, apoE x DMPC markedly increased cGMP in ADP-stimulated platelets which correlated with the resulting inhibition of aggregation (r = 0.85; p < 0.01, n = 10), whereas cyclohexanedione-apoE x DMPC vesicles had no effect. Adenosine Diphosphate 45-48 apolipoprotein E Homo sapiens 6-10 8995232-6 1997 Thus, apoE x DMPC markedly increased cGMP in ADP-stimulated platelets which correlated with the resulting inhibition of aggregation (r = 0.85; p < 0.01, n = 10), whereas cyclohexanedione-apoE x DMPC vesicles had no effect. Adenosine Diphosphate 45-48 apolipoprotein E Homo sapiens 190-194 9193650-2 1997 We report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP-ribosyltransferase activity and that Rt6, but not RT6, catalyzes the ADP-ribosylation of exogenous histones. Adenosine Diphosphate 81-84 ADP-ribosyltransferase 2b Rattus norvegicus 19-24 9193655-10 1997 Although the precise mechanism requires further investigation, our results indicate that ADP-ribosylation is a crucial step restricted to the signalling pathway which leads to iNOS mRNA induction, as well as TNF and MHC class II induction during macrophage activation. Adenosine Diphosphate 89-92 nitric oxide synthase 2, inducible Mus musculus 176-180 9193652-4 1997 The recombinant RT6.1 and RT6.2 displayed extremely low auto-ADP-ribosylation, though the latter modification was somewhat higher than the former one. Adenosine Diphosphate 61-64 ADP-ribosyltransferase 2b Rattus norvegicus 16-21 9193655-10 1997 Although the precise mechanism requires further investigation, our results indicate that ADP-ribosylation is a crucial step restricted to the signalling pathway which leads to iNOS mRNA induction, as well as TNF and MHC class II induction during macrophage activation. Adenosine Diphosphate 89-92 tumor necrosis factor Mus musculus 208-211 9193669-5 1997 Since ADP-ribosylarginine hydrolase, the enzyme responsible for cleavage of the ADP-ribosylarginine bond and a component with the transferase of a putative ADP-ribosylation cycle, is cytosolic, whereas the transferase is attached via a GPI-anchor to the cell surface, the processing of ADP-ribosylated integrin alpha 7 was investigated. Adenosine Diphosphate 6-9 integrin alpha-7 Oryctolagus cuniculus 302-318 9193652-4 1997 The recombinant RT6.1 and RT6.2 displayed extremely low auto-ADP-ribosylation, though the latter modification was somewhat higher than the former one. Adenosine Diphosphate 61-64 ADP-ribosyltransferase 2b Rattus norvegicus 26-31 9193669-6 1997 32P label was rapidly removed from [32P]ADP-ribosylated integrin alpha 7, a process inhibited by free ADP-ribose or p-nitrophenylthymidine-5"-monophosphate, alternative substrates for 5"-nucleotide phosphodiesterase. Adenosine Diphosphate 40-43 integrin alpha-7 Oryctolagus cuniculus 56-72 20297942-0 1997 "ADP-induced binding of fibrinogen to activated platelets is rapid and parallels platelet microaggregation". Adenosine Diphosphate 1-4 fibrinogen beta chain Homo sapiens 24-34 16793654-2 1997 P-selectin expression in response to no added stimulus (spontaneous activation) or in response to adenosine diphosphate (ADP) and epinephrine or thrombin, was assessed using a flow cytometric assay. Adenosine Diphosphate 98-119 selectin, platelet Mus musculus 0-10 8940119-10 1996 Thin layer chromatography analysis of the hydrolysis reaction products revealed that ATP was rapidly converted to ADP followed by a much slower conversion of ADP to AMP when incubated with wild type tTG or the DeltaP345 mutant. Adenosine Diphosphate 158-161 transglutaminase 2 Homo sapiens 199-202 16793654-2 1997 P-selectin expression in response to no added stimulus (spontaneous activation) or in response to adenosine diphosphate (ADP) and epinephrine or thrombin, was assessed using a flow cytometric assay. Adenosine Diphosphate 121-124 selectin, platelet Mus musculus 0-10 9297192-12 1997 In PRP from healthy subjects aggregatory responses to ADP and arachidonic acid were significantly higher at 17:30 than at 8:00. Adenosine Diphosphate 54-57 prion protein Homo sapiens 3-6 8990354-3 1996 Quiescent EC express the ectoenzyme ATP-diphosphohydrolase (ATPDase; an apyrase), which exerts an important thromboregulatory function by hydrolyzing both ATP and ADP. Adenosine Diphosphate 163-166 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 36-58 8990354-3 1996 Quiescent EC express the ectoenzyme ATP-diphosphohydrolase (ATPDase; an apyrase), which exerts an important thromboregulatory function by hydrolyzing both ATP and ADP. Adenosine Diphosphate 163-166 ectonucleoside triphosphate diphosphohydrolase 1 Rattus norvegicus 60-67 8985170-1 1996 Poly-ADP ribosylation of nuclear proteins is activated when poly(ADP-ribose) polymerase (PARP), a nuclear zinc-finger enzyme, binds to single-strand DNA breaks. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 60-87 8985170-1 1996 Poly-ADP ribosylation of nuclear proteins is activated when poly(ADP-ribose) polymerase (PARP), a nuclear zinc-finger enzyme, binds to single-strand DNA breaks. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 89-93 8961941-7 1996 An enhancement of the rate of the ADP-dependent PYM binding was observed upon digestion of the protein bound phospholipid by phospholipase A2. Adenosine Diphosphate 34-37 phospholipase A2 group IB Homo sapiens 125-141 8972712-0 1996 Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 92-100 8922366-6 1996 Concomitantly, IL-1beta significantly decreased islet ATP (-45%), GTP (-33%), ATP/ADP (-54%), and GTP/GDP (-46%). Adenosine Diphosphate 82-85 interleukin 1 beta Rattus norvegicus 15-23 8922366-12 1996 Thus, in rat islets, IL-1beta (via the generation of NO) abolishes insulin exocytosis in association with large decreases in the ATP/ADP (and GTP/GDP) ratio, implying the impairment of mitochondrial function. Adenosine Diphosphate 133-136 interleukin 1 beta Rattus norvegicus 21-29 8973601-6 1996 Similarly, the changes in the levels of ADP-ribosylation correlated with the changes in the levels of CEA during the clinical course (r = 0.58; P < 0.05). Adenosine Diphosphate 40-43 CEA cell adhesion molecule 3 Homo sapiens 102-105 8939882-0 1996 Glutamic acid 207 in rodent T-cell RT6 antigens is essential for arginine-specific ADP-ribosylation. Adenosine Diphosphate 83-86 ADP-ribosyltransferase 2b Rattus norvegicus 35-38 8941705-1 1996 Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 31-37 8941705-1 1996 Poly(ADP-ribosyl) transferase (pADPRT) catalyzes the transfer of the ADP-ribose moiety from NAD+ onto proteins as well as onto protein-bound ADP-ribose. Adenosine Diphosphate 32-35 poly(ADP-ribose) polymerase 1 Homo sapiens 0-29 8972712-3 1996 We investigated how these endogenous agonists influenced the effects of PGE1 on thrombin (2.0 U/ml)-induced tyrosine phosphorylation by removing released ADP with apyrase (2.0 U/ml) and by inhibiting thromboxane A2 synthesis with indomethacin (1 microM). Adenosine Diphosphate 154-157 coagulation factor II, thrombin Homo sapiens 80-88 8978479-4 1996 Incubation of cholesta-5,7-dien-3 beta-ol with rat liver microsomes in the presence of ADP/Fe2+ and NADPH gave rise to a number of oxygenated sterols. Adenosine Diphosphate 87-90 integrin subunit beta 1 Rattus norvegicus 34-41 8843545-3 1996 However, the secondary wave of platelet aggregation induced by adenosine diphosphate (ADP) was enhanced by TPO in a dose-dependent manner. Adenosine Diphosphate 86-89 thrombopoietin Homo sapiens 107-110 8765089-0 1996 Adenosine diphosphate inhibits the serotonin transporter. Adenosine Diphosphate 0-21 solute carrier family 6 member 4 Homo sapiens 35-56 8901474-3 1996 Mitochondrial swelling in the hypo-osmotic medium resulted in the sharp decrease of the value of Km for ADP in correlation with the degree of rupture of mitochondrial outer membrane, as determined by the cytochrome c test. Adenosine Diphosphate 104-107 cytochrome c, somatic Homo sapiens 204-216 9863151-3 1996 RESULTS: Gomisin J inhibited Fe2+/ascorbic acid and ADP/NADPH-induced LPO with IC50 (95% confidence limits) 5.5 (4.5-6.7) and 4.7 (2.8-7.8) mumol.L-1, respectively, when cultured myocardial cells preincubated with Ca(2+)-free medium for 2 min were incubated with normal medium containing Ca2+, a marked increase of malondialdehyde (MDA) formation occurred and gomisin J 10 mumol.L-1 protected myocardial cells through decreasing MDA formation. Adenosine Diphosphate 52-55 carbonic anhydrase 2 Rattus norvegicus 288-291 8760375-0 1996 Calcium-dependent ADP-ribosylation of high-mobility-group I (HMGI) proteins. Adenosine Diphosphate 18-21 high mobility group AT-hook 1 Mus musculus 38-59 8760375-0 1996 Calcium-dependent ADP-ribosylation of high-mobility-group I (HMGI) proteins. Adenosine Diphosphate 18-21 high mobility group AT-hook 1 Mus musculus 61-65 8832286-3 1996 An important pathway of ONOO- cytotoxicity involves DNA strand breakage, activation of the nuclear repair enzyme poly(ADP) ribosyltransferase (PARS), and concomitant ADP-ribosylation, NAD+ consumption, and exhaustion of intracellular energy stores. Adenosine Diphosphate 118-121 poly(ADP-ribose) polymerase 1 Homo sapiens 143-147 8843545-3 1996 However, the secondary wave of platelet aggregation induced by adenosine diphosphate (ADP) was enhanced by TPO in a dose-dependent manner. Adenosine Diphosphate 63-84 thrombopoietin Homo sapiens 107-110 8843545-4 1996 TPO in conjunction with ADP augmented tyrosine phosphorylation of platelet proteins, including tyrosine-phosphorylated proteins induced by TPO alone. Adenosine Diphosphate 24-27 thrombopoietin Homo sapiens 139-142 8843545-5 1996 Genistein inhibited protein-tyrosine phosphorylation in platelets induced by TPO with ADP and suppressed TPO-enhanced platelet aggregation. Adenosine Diphosphate 86-89 thrombopoietin Homo sapiens 77-80 8843545-6 1996 Moreover, tyrosine phosphorylation of MAP-kinases induced by TPO alone and TPO with ADP was consistent with TPO-enhanced platelet aggregation. Adenosine Diphosphate 84-87 thrombopoietin Homo sapiens 75-78 8843545-6 1996 Moreover, tyrosine phosphorylation of MAP-kinases induced by TPO alone and TPO with ADP was consistent with TPO-enhanced platelet aggregation. Adenosine Diphosphate 84-87 thrombopoietin Homo sapiens 75-78 8663002-2 1996 A recent study has indicated that a 29-kDa dispase-digestive fragment from the C-terminal heparin-binding domain of human plasma fibronectin (lacking RGD sequence) inhibits binding of fibronectin to thrombin-stimulated platelets and ADP-induced aggregation (Tanabe, J. , Fujita, H., Iwamatsu, A., Mohri, H., and Ohkubo, T.(1993) J. Biol. Adenosine Diphosphate 233-236 fibronectin 1 Homo sapiens 129-140 8666796-5 1996 We now report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP ribosylation activity. Adenosine Diphosphate 85-88 ADP-ribosyltransferase 2b Rattus norvegicus 23-28 8663002-2 1996 A recent study has indicated that a 29-kDa dispase-digestive fragment from the C-terminal heparin-binding domain of human plasma fibronectin (lacking RGD sequence) inhibits binding of fibronectin to thrombin-stimulated platelets and ADP-induced aggregation (Tanabe, J. , Fujita, H., Iwamatsu, A., Mohri, H., and Ohkubo, T.(1993) J. Biol. Adenosine Diphosphate 233-236 fibronectin 1 Homo sapiens 184-195 8663002-2 1996 A recent study has indicated that a 29-kDa dispase-digestive fragment from the C-terminal heparin-binding domain of human plasma fibronectin (lacking RGD sequence) inhibits binding of fibronectin to thrombin-stimulated platelets and ADP-induced aggregation (Tanabe, J. , Fujita, H., Iwamatsu, A., Mohri, H., and Ohkubo, T.(1993) J. Biol. Adenosine Diphosphate 233-236 coagulation factor II, thrombin Homo sapiens 199-207 8663002-5 1996 We provide here the evidence that a peptide corresponding to residues from Ala1704 to Glu1718 (designated F1) from this fragment inhibited binding of 125I-labeled 29-kDa fragment of fibronectin to thrombin-stimulated platelets and ADP-induced aggregation. Adenosine Diphosphate 231-234 fibronectin 1 Homo sapiens 182-193 8663002-5 1996 We provide here the evidence that a peptide corresponding to residues from Ala1704 to Glu1718 (designated F1) from this fragment inhibited binding of 125I-labeled 29-kDa fragment of fibronectin to thrombin-stimulated platelets and ADP-induced aggregation. Adenosine Diphosphate 231-234 coagulation factor II, thrombin Homo sapiens 197-205 8690084-5 1996 The recombinant RT6.1 and RT6.2 displayed extremely low auto-ADP-ribosylation, although the latter modification was somewhat higher than the former. Adenosine Diphosphate 61-64 ADP-ribosyltransferase 2b Rattus norvegicus 16-21 8690084-5 1996 The recombinant RT6.1 and RT6.2 displayed extremely low auto-ADP-ribosylation, although the latter modification was somewhat higher than the former. Adenosine Diphosphate 61-64 ADP-ribosyltransferase 2b Rattus norvegicus 26-31 8807774-1 1996 The addition of C-reactive protein (CRP) to bovine platelets suspended in homologous plasma consistently produced a reversible aggregation response following stimulation with either platelet activating factor or adenosine diphosphate while untreated control samples exhibited irreversible aggregation. Adenosine Diphosphate 212-233 C-reactive protein Bos taurus 16-34 8807774-1 1996 The addition of C-reactive protein (CRP) to bovine platelets suspended in homologous plasma consistently produced a reversible aggregation response following stimulation with either platelet activating factor or adenosine diphosphate while untreated control samples exhibited irreversible aggregation. Adenosine Diphosphate 212-233 C-reactive protein Bos taurus 36-39 8639835-3 1996 Using hirudin as an anticoagulant, thrombopoietin (1 to 100 ng/mL) enhanced platelet aggregation induced by 2 micromol/L adenosine-diphosphate (ADP) in a dose dependent fashion. Adenosine Diphosphate 121-142 thrombopoietin Homo sapiens 35-49 8639835-3 1996 Using hirudin as an anticoagulant, thrombopoietin (1 to 100 ng/mL) enhanced platelet aggregation induced by 2 micromol/L adenosine-diphosphate (ADP) in a dose dependent fashion. Adenosine Diphosphate 144-147 thrombopoietin Homo sapiens 35-49 8666796-5 1996 We now report that rat RT6.2 and recombinant mouse Rt6 locus 1 proteins possess auto-ADP ribosylation activity. Adenosine Diphosphate 85-88 ADP-ribosyltransferase 2b Rattus norvegicus 51-54 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 4-7 ADP-ribosyltransferase 2b Rattus norvegicus 58-63 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 38-41 ADP-ribosyltransferase 2b Rattus norvegicus 58-63 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 38-41 ADP-ribosyltransferase 2b Rattus norvegicus 58-63 8611426-4 1996 Meth A cells exposed to SAGP underwent an increase in labelling of the alpha-subunit of an inhibitory guanine nucleotide-binding (Gi) protein in a subsequent IAP-catalysed [32P]ADP ribosylation of the cell membrane fraction. Adenosine Diphosphate 177-180 intracisternal A particle, Eya1 linked Mus musculus 158-161 8664294-5 1996 The allosteric effector ADP, alkaline pH, and phosphorylation by cAMP-dependent protein kinase, all activators of PbK, did not cause significant changes in its relative affinity for P-b; however, Ca2+ and Mg2+ ions, which also stimulate PbK, increased its affinity for P-b, with Mg2+ being more effective. Adenosine Diphosphate 24-27 PDZ binding kinase Homo sapiens 114-117 8651946-10 1996 Adenosine formed by hydrolysis from ATP and ADP, by contrast, reduces the oxidative bursts and the influx of extracellular calcium induced by fMLP. Adenosine Diphosphate 44-47 formyl peptide receptor 1 Homo sapiens 142-146 8726359-7 1996 NBD-CI also inhibited ADP-induced shape change, aggregation, exposure of fibrinogen binding sites, secretion, and calcium mobilization in washed platelets. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 73-83 8631786-7 1996 The phosphorylation of Vav in response to thrombin was maximal within 15 s and was unaffected by aspirin, inhibitors of aggregation, or the presence of the ADP scavenger, apyrase. Adenosine Diphosphate 156-159 coagulation factor II, thrombin Homo sapiens 42-50 8639892-6 1996 MGDF also "primed" the release of adenosine triphosphates and the production of thromboxane B2 by platelets stimulated with ADP, EPI, and THR. Adenosine Diphosphate 124-127 thrombopoietin Homo sapiens 0-4 8639892-7 1996 When added 15 seconds after the preincubation of platelets with subthreshold concentrations of ADP, EPI, and THR, MGDF exhibited a synergism with these agonists. Adenosine Diphosphate 95-98 thrombopoietin Homo sapiens 114-118 8639892-8 1996 Moreover, we observed a "priming" effect of MGDF on the phosphorylation of p-42 mitogen-activated protein kinase promoted by ADP, EPI, and THR. Adenosine Diphosphate 125-128 thrombopoietin Homo sapiens 44-48 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 100-123 insulin Homo sapiens 17-24 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 100-123 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 100-123 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 100-123 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 125-128 insulin Homo sapiens 17-24 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 125-128 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 125-128 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 125-128 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 166-169 insulin Homo sapiens 17-24 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 166-169 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 166-169 insulin Homo sapiens 184-191 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 166-169 insulin Homo sapiens 184-191 8731510-3 1996 On the contrary, at very elevated concentrations (25-200 nmol/L) insulin increases platelet aggregation to ADP (ADP ED50 with 200 nmol/L insulin being 81 +/- 4% of the basal value, p = 0.01), decreases intraplatelet content of cGMP (from basal 7.2 +/- 0.1 pmol/10(9) plts to 5.7 +/- 0.2 pmol/10(9) plts with 200 nmol/L insulin, p = 0.01) and attenuates the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 107-110 insulin Homo sapiens 65-72 8731510-3 1996 On the contrary, at very elevated concentrations (25-200 nmol/L) insulin increases platelet aggregation to ADP (ADP ED50 with 200 nmol/L insulin being 81 +/- 4% of the basal value, p = 0.01), decreases intraplatelet content of cGMP (from basal 7.2 +/- 0.1 pmol/10(9) plts to 5.7 +/- 0.2 pmol/10(9) plts with 200 nmol/L insulin, p = 0.01) and attenuates the platelet cGMP increase induced by nitrates. Adenosine Diphosphate 107-110 insulin Homo sapiens 137-144 9095470-8 1996 Determination of high energy phosphates showed that 24 h TNF alpha-exposure resulted in a reversible decrease of ATP, ADP, AMP and CP by 30-40% (p < 0.05). Adenosine Diphosphate 118-121 tumor necrosis factor Rattus norvegicus 57-66 8619986-8 1996 However, addition of 2.0 mM MgADP to the motility assay buffer induced movement of all the I341A filaments at a velocity (1.6 +/- 0.1 microns/s) similar to that of wild-type actin (1.7 +/- 0.1 microns/s). Adenosine Diphosphate 28-33 actin Saccharomyces cerevisiae S288C 174-179 8700870-4 1996 The rate of GroEL dissociation from the nonnative chain was increased significantly in the presence of 5"-adenylylimidodiphosphate (AMP-PNP), ADP, and ATP, yielding maximal values between 0.04 and 0.22 s(-1). Adenosine Diphosphate 142-145 GroEL Escherichia coli 12-17 8630404-7 1996 Increasing mitochondrial respiratory rate and enzyme activities by long-term culture with 2 mmol/L adenosine 5"-diphosphate (ADP) and Pi sensitized both drug-sensitive and drug-resistant cells to TNFalpha-induced cytolysis. Adenosine Diphosphate 99-123 tumor necrosis factor Homo sapiens 196-204 8630404-7 1996 Increasing mitochondrial respiratory rate and enzyme activities by long-term culture with 2 mmol/L adenosine 5"-diphosphate (ADP) and Pi sensitized both drug-sensitive and drug-resistant cells to TNFalpha-induced cytolysis. Adenosine Diphosphate 125-128 tumor necrosis factor Homo sapiens 196-204 8634430-14 1996 During the first week of rHu-MGDF treatment ex vivo platelet aggregatory responsiveness was enhanced to physiologic agonists (adenosine diphosphate, collagen, and thrombin receptor agonist peptide, TRAP1-6) (P < .05 in all cases). Adenosine Diphosphate 126-147 thrombopoietin Homo sapiens 29-33 8608802-3 1996 The addition of C3 to the culture medium caused ADP-ribosylation of the rho proteins in CMK cells in a dose- and time-dependent manner. Adenosine Diphosphate 48-51 C-X-C motif chemokine ligand 9 Homo sapiens 88-91 8619986-9 1996 The decrease in motility of the I341A actin filaments in the absence of ADP was attributed to a negative load slowing the mutant filaments and the smaller force produced by the heavy meromyosin and I341A actin system. Adenosine Diphosphate 72-75 actin Saccharomyces cerevisiae S288C 38-43 8619986-9 1996 The decrease in motility of the I341A actin filaments in the absence of ADP was attributed to a negative load slowing the mutant filaments and the smaller force produced by the heavy meromyosin and I341A actin system. Adenosine Diphosphate 72-75 actin Saccharomyces cerevisiae S288C 204-209 9054055-3 1996 Here we demonstrate that platelet cholesterol depletion is an improbable explanation for the suppressive effect of apoE:DMPC on ADP-mediated platelet aggregation; only 0.5% of cholesterol was released prior to addition of ADP to initiate aggregation while lactoferrin, which does not accept cellular cholesterol, was also inhibitory. Adenosine Diphosphate 128-131 apolipoprotein E Homo sapiens 115-119 9112649-2 1996 Collagen- and ADP-induced platelet aggregation in PRP was found to be diminished following incubation with ET-1 for 1 and 5 min at the concentrations of 0.1 microM and 0.2 microM. Adenosine Diphosphate 14-17 endothelin 1 Homo sapiens 107-123 12226222-4 1996 Thus the ADP-Glc accumulation in bt1 endosperm cells was not due to a deficiency in starch synthase. Adenosine Diphosphate 9-12 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 33-36 12226222-5 1996 ADP-Glc content in extracts of sh1bt1 endosperms was similar to that in bt1, but in extracts of the sh2bt1 mutant kernels ADP-Glc content was much reduced compared to bt1 (about 3 times higher than that in normal). Adenosine Diphosphate 0-3 adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial Zea mays 34-37 9054055-0 1996 Inhibition of ADP-induced platelet aggregation by apoE is not mediated by membrane cholesterol depletion. Adenosine Diphosphate 14-17 apolipoprotein E Homo sapiens 50-54 9054055-3 1996 Here we demonstrate that platelet cholesterol depletion is an improbable explanation for the suppressive effect of apoE:DMPC on ADP-mediated platelet aggregation; only 0.5% of cholesterol was released prior to addition of ADP to initiate aggregation while lactoferrin, which does not accept cellular cholesterol, was also inhibitory. Adenosine Diphosphate 222-225 apolipoprotein E Homo sapiens 115-119 8611582-5 1996 Kinetic evaluation of E381A and two other mutants, E381D and E381S, showed that their primary defect was a lower kcat in the ADP-ribosylation of soybean trypsin inhibitor (SBTI). Adenosine Diphosphate 125-128 kunitz trypsin protease inhibitor Glycine max 153-170 9772654-3 1996 RESULTS: In the presence of Ca2+ 1 mmol.L-1, Tet 300 mumol.L-1 inhibited the aggregation induced by ADP (25 mumol.L-1), collagen (2.5 g.L-1), and thrombin (103 unit.L-1) by 62%, 60%, and 34%, respectively. Adenosine Diphosphate 100-103 coagulation factor II Rattus norvegicus 146-154 8599934-1 1996 We have observed that stimulation of human natural killer cells with dibutyryl cAMP (Bt2cAMP) reproduced the effects of ADP ribosylation of the GTP binding protein RhoA by Clostridium botulinum C3 transferase: both agents induced similar morphological changes, inhibited cell motility and blocked the cytolytic function. Adenosine Diphosphate 120-123 ras homolog family member A Homo sapiens 164-168 8579366-8 1996 Thus, the modulation by tBOOH appears to be largely dependent upon the changes in [Ca2+]i. Receptor mediated stimulation of the respiratory burst (ADP stimulation) involves release of Ca2+ from the inositol-1,4,5-triphosphate (IP3)-sensitive pool in the endoplasmic reticulum. Adenosine Diphosphate 147-150 carbonic anhydrase 2 Rattus norvegicus 83-86 8579366-8 1996 Thus, the modulation by tBOOH appears to be largely dependent upon the changes in [Ca2+]i. Receptor mediated stimulation of the respiratory burst (ADP stimulation) involves release of Ca2+ from the inositol-1,4,5-triphosphate (IP3)-sensitive pool in the endoplasmic reticulum. Adenosine Diphosphate 147-150 carbonic anhydrase 2 Rattus norvegicus 184-187 8821526-4 1996 GEA 3162, GEA 3175, SIN-1 and SNAP inhibited adenosine 5"-diphosphate-induced platelet aggregation (IC50 values 0.18, 0.39, 3.73 and 2.12 microM, respectively). Adenosine Diphosphate 45-69 MAPK associated protein 1 Homo sapiens 20-25 8850303-1 1996 The cells of the human monocytic leukemia cell line THP-1 differentiated into macrophages bound to human erythrocytes oxidized with adenosine 5"-diphosphate (ADP)-Fe3+ chelate (ADP/Fe3+) in the absence of serum. Adenosine Diphosphate 132-156 GLI family zinc finger 2 Homo sapiens 52-57 8850303-1 1996 The cells of the human monocytic leukemia cell line THP-1 differentiated into macrophages bound to human erythrocytes oxidized with adenosine 5"-diphosphate (ADP)-Fe3+ chelate (ADP/Fe3+) in the absence of serum. Adenosine Diphosphate 158-161 GLI family zinc finger 2 Homo sapiens 52-57 8850303-1 1996 The cells of the human monocytic leukemia cell line THP-1 differentiated into macrophages bound to human erythrocytes oxidized with adenosine 5"-diphosphate (ADP)-Fe3+ chelate (ADP/Fe3+) in the absence of serum. Adenosine Diphosphate 177-180 GLI family zinc finger 2 Homo sapiens 52-57 8850303-2 1996 The binding was prevented when the cells were treated with ADP/Fe3+ in the presence of antioxidants, indicating that oxidation of the cells is responsible for the increased susceptibility to the THP-1 cell binding. Adenosine Diphosphate 59-62 GLI family zinc finger 2 Homo sapiens 195-200 9252788-1 1996 Adenylate kinase (AK; EC 2.7.4.3, hAK1) catalyzes the reaction: MgATP(2-)+ AMP2- reversible MgADP-(+) ADP3-. Adenosine Diphosphate 92-97 adenylate kinase 1 Homo sapiens 34-38 8919301-5 1996 On post-receptor level, chronic morphine treatment substantially increased the abundance and functional activity of stimulatory G proteins, as assessed by cholera toxin-catalyzed ADP-ribosylation of GSalpha and S49 cyc- reconstitution assays. Adenosine Diphosphate 179-182 GNAS complex locus Homo sapiens 199-206 8920207-2 1996 In vitro ADP-ribosylation has been demonstrated with diverse substrates such as phosphorylase kinase, actin, and Gs alpha resulting in the alteration of substrate function. Adenosine Diphosphate 9-12 GNAS complex locus Homo sapiens 113-121 8777140-3 1996 Gs alpha is also a substrate for choleragen catalyzed ADP-ribosylation when it is associated with G beta gamma but not as free Gs alpha. Adenosine Diphosphate 54-57 GNAS complex locus Homo sapiens 0-8 8555481-4 1996 Both beta 3 fragments blocked the participation of fibrinogen in the induction of platelet aggregation induced by adenosine diphosphate. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 51-61 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 209-211 8855453-4 1996 Phorbol myristate acetate (PMA) and ADP, which stimulate the respiratory burst, caused NF Kappa B activation in both cells. Adenosine Diphosphate 36-39 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 87-97 8614272-2 1996 IGF-1 (100 nM) reduced EC50 values for thrombin, collagen and ADP-induced aggregation by 19.6%, 53.6% and 22.8% respectively. Adenosine Diphosphate 62-65 insulin like growth factor 1 Homo sapiens 0-5 21043669-2 1996 Utilising impedance aggregometry in whole human blood (normal subjects and patients with coronary artery disease) we observed potentiation of pro-aggregatory effects of ADP by the combination of adrenaline, serotonin and thrombin in subthreshold concentrations (multiple agonist approach). Adenosine Diphosphate 169-172 coagulation factor II, thrombin Homo sapiens 221-229 9030240-3 1996 ADP was able to induce a transient increase in the cytoplasmic Ca2+ concentration in tumor cells from all lines; collagen showed this effect in mesothelioma cells and in HeLa cells, and thrombin was effective only in mesothelioma cells. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 186-194 8907197-0 1996 Activation of Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of RhoA by K+ in a Mg2+ -dependent manner. Adenosine Diphosphate 59-62 ras homolog family member A Homo sapiens 79-83 8907197-3 1996 The increase in ADP-ribose incorporation into RhoA due to KCl appeared in the presence of MgCl2 and was abolished by EDTA. Adenosine Diphosphate 16-19 ras homolog family member A Homo sapiens 46-50 21043593-4 1996 Nabumetone was found to cause a significant decrease in platelet-bound fibrinogen after adenosine diphosphate (ADP) activation using flow cytometry and a significant increase in IVBT when using CaCl(2) as activating substance. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 71-81 21043593-4 1996 Nabumetone was found to cause a significant decrease in platelet-bound fibrinogen after adenosine diphosphate (ADP) activation using flow cytometry and a significant increase in IVBT when using CaCl(2) as activating substance. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 71-81 21043595-4 1996 ADP alone caused a significant and sustained increase in the cytoskeletal content of actin binding protein (ABP), myosin, alpha-actinin, a 66K protein and actin, and a significant decrease in a 31K protein. Adenosine Diphosphate 0-3 sex hormone binding globulin Homo sapiens 85-106 21043595-4 1996 ADP alone caused a significant and sustained increase in the cytoskeletal content of actin binding protein (ABP), myosin, alpha-actinin, a 66K protein and actin, and a significant decrease in a 31K protein. Adenosine Diphosphate 0-3 sex hormone binding globulin Homo sapiens 108-111 21043595-4 1996 ADP alone caused a significant and sustained increase in the cytoskeletal content of actin binding protein (ABP), myosin, alpha-actinin, a 66K protein and actin, and a significant decrease in a 31K protein. Adenosine Diphosphate 0-3 actinin alpha 1 Homo sapiens 122-135 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 213-216 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 230-240 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 88-109 fibrinogen beta chain Homo sapiens 213-215 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 209-211 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 213-216 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 230-240 21043648-1 1996 Human blood platelets can be activated by a variety of physiological activators such as adenosine diphosphate (ADP), thrombin or collagen, leading to activation of GPIIb-IIIa into a high-affinity receptor for Fg (FgR), binding of fibrinogen (Fg), and subsequent platelet aggregation required for normal hemostasis. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 213-215 21043648-3 1996 Since platelet activation and aggregation occur within ~1 s of stirring with activators such as ADP, a methodology was required for determining the rapid dynamics of expression of FgR and binding of Fg, and their correlation with platelet aggregation kinetics. Adenosine Diphosphate 96-99 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 180-183 21043648-3 1996 Since platelet activation and aggregation occur within ~1 s of stirring with activators such as ADP, a methodology was required for determining the rapid dynamics of expression of FgR and binding of Fg, and their correlation with platelet aggregation kinetics. Adenosine Diphosphate 96-99 fibrinogen beta chain Homo sapiens 180-182 21043648-5 1996 This approach has yielded a novel general technique for assessing the rapid dynamics of any cell surface molecule, as well as unexpected new insights into the kinetic expression and nature of FgR formed on platelet surfaces activated with ADP and PMA. Adenosine Diphosphate 239-242 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 192-195 21043648-7 1996 Parallel measurements of kinetics of platelet recruitment into microaggregates and expression and Fg occupancy of FgR as a function of ADP concentration, led to an unexpected new model for platelet activation and recruitment based once again on the selective recruitment of platelet subpopulation and an "all or none, quantal" response of any single platelet in expressing all of its FgR and becoming recruitable for aggregation, but at a critical ADP concentration dependent on its own subpopulation characteristics. Adenosine Diphosphate 135-138 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 114-117 7593235-8 1995 Adenosine diphosphate, a potent stimulator of cell migration which enhances expression of u-PA and PAI-1 in nonwounded cultures, additively stimulates these genes after wounding and may thereby potentiate wound healing. Adenosine Diphosphate 0-21 plasminogen activator, urokinase Homo sapiens 90-94 8554519-3 1995 Stimulation of human platelet membranes with ADP resulted in an increase in 4-azidoanilido-[alpha-32P]GTP incorporation into the immunoprecipitates of G alpha i but not of G alpha q proteins, whereas stimulation with the thromboxane analogue U46619 resulted in an increase in 4-azidoanilido-[alpha-32P]GTP incorporation into the immunoprecipitates of G alpha q but not of G alpha i proteins, and thrombin activated both G-proteins. Adenosine Diphosphate 45-48 coagulation factor II, thrombin Homo sapiens 396-404 8554519-5 1995 Using specific antisera against subtypes of Gi proteins, we found that ADP stimulated labelling of the G alpha 12 immunoprecipitate, but not of the G alpha 13 precipitate. Adenosine Diphosphate 71-74 G protein subunit alpha 12 Homo sapiens 103-113 8554519-7 1995 These data suggest that ADP inhibits cAMP formation by activation of G alpha 12 proteins and add evidence in support of the hypothesis that human platelet ADP receptors do not activate PLC through Gq activation. Adenosine Diphosphate 24-27 G protein subunit alpha 12 Homo sapiens 69-79 7492761-11 1995 TPO-induced binding of fibrinogen to platelets was comparable in degree with that observed by stimulation with 10 mumol/L ADP. Adenosine Diphosphate 122-125 thrombopoietin Homo sapiens 0-3 8610278-0 1995 Inhibition of ADP-induced platelet aggregation by apoE is not mediated by membrane cholesterol depletion. Adenosine Diphosphate 14-17 apolipoprotein E Homo sapiens 50-54 8610278-3 1995 Here we demonstrate that platelet cholesterol depletion is an improbable explanation for the suppressive effect of apoE:DMPC on ADP-mediated platelet aggregation; only 0.5% of cholesterol was released prior to addition of ADP to initiate aggregation while lactoferrin, which does not accept cellular cholesterol, was also inhibitory. Adenosine Diphosphate 128-131 apolipoprotein E Homo sapiens 115-119 8610278-3 1995 Here we demonstrate that platelet cholesterol depletion is an improbable explanation for the suppressive effect of apoE:DMPC on ADP-mediated platelet aggregation; only 0.5% of cholesterol was released prior to addition of ADP to initiate aggregation while lactoferrin, which does not accept cellular cholesterol, was also inhibitory. Adenosine Diphosphate 222-225 apolipoprotein E Homo sapiens 115-119 8594881-2 1995 In the present studies, we examined the effects of nucleotides (ATP, UTP, and ADP; 10 microM each) on the arginine vasopressin (AVP, 0.1 nM)-stimulated osmotic water permeability (Pf) in in vitro perfused terminal inner medullary collecting ducts (IMCD) of rat. Adenosine Diphosphate 78-81 arginine vasopressin Rattus norvegicus 115-126 8772241-5 1995 ET-1 injection inhibited ex vivo platelet aggregation induced by ADP and U-46619 by 30-60%. Adenosine Diphosphate 65-68 endothelin 1 Canis lupus familiaris 0-4 7589830-3 1995 Insulin induced a dose-dependent decrease of platelet aggregation to ADP (P = 0.0001) in healthy subjects. Adenosine Diphosphate 69-72 insulin Homo sapiens 0-7 8772218-4 1995 Thus, after induction of vWF release from platelets by polybrene or ADP, platelet function was normal. Adenosine Diphosphate 68-71 von Willebrand factor Homo sapiens 25-28 8772234-2 1995 Although TPO itself did not cause platelet aggregation, it upregulated ADP-induced aggregation, especially the second wave of aggregation. Adenosine Diphosphate 71-74 thrombopoietin Homo sapiens 9-12 8772235-3 1995 Human fibrinogen is saline was labeled with equimolar acridinium dissolved in dimethylformamide, and allowed to react with gel-filtered human platelets in the presence of ADP. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 6-16 8772235-6 1995 Acridinium-fibrinogen binding to human platelets was rapid and reversible, specific and saturable, and dependent on ADP concentrations. Adenosine Diphosphate 116-119 fibrinogen beta chain Homo sapiens 11-21 7492595-0 1995 The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM. Adenosine Diphosphate 103-106 AAA family ATPase CDC48 Saccharomyces cerevisiae S288C 32-38 7589830-5 1995 On the contrary, in insulin-resistant subjects, insulin reduced platelet sensitivity to ADP only at a concentration of 1,920 pmol/l. Adenosine Diphosphate 88-91 insulin Homo sapiens 20-27 7589830-5 1995 On the contrary, in insulin-resistant subjects, insulin reduced platelet sensitivity to ADP only at a concentration of 1,920 pmol/l. Adenosine Diphosphate 88-91 insulin Homo sapiens 48-55 7589830-6 1995 When ADP ED50 values obtained in platelet-rich plasma incubated with insulin were expressed in percentage of the ADP ED50 values obtained in platelet-rich plasma without insulin, considered as 100%, we observed that ADP ED50 with 1,920 pmol/l insulin was 153.6 +/- 13.2% in the younger healthy subject group (P = 0.004), 150.0 +/- 3.8% in the older healthy subject group (P = 0.0001), 116.1 +/- 6.1% in obese subjects (P = 0.031), and 120.0 +/- 8.6% in NIDDM patients (P = 0.05). Adenosine Diphosphate 5-8 insulin Homo sapiens 69-76 7589830-6 1995 When ADP ED50 values obtained in platelet-rich plasma incubated with insulin were expressed in percentage of the ADP ED50 values obtained in platelet-rich plasma without insulin, considered as 100%, we observed that ADP ED50 with 1,920 pmol/l insulin was 153.6 +/- 13.2% in the younger healthy subject group (P = 0.004), 150.0 +/- 3.8% in the older healthy subject group (P = 0.0001), 116.1 +/- 6.1% in obese subjects (P = 0.031), and 120.0 +/- 8.6% in NIDDM patients (P = 0.05). Adenosine Diphosphate 113-116 insulin Homo sapiens 69-76 7577949-8 1995 Immobilized 5-lipoxygenase on ATP-agarose was found to be selectively eluted by adenine nucleotides (ATP > ADP > AMP) but not by solutions containing high salt concentrations, mild detergents, arachidonic acid, or inhibitors. Adenosine Diphosphate 110-113 arachidonate 5-lipoxygenase Homo sapiens 12-26 8563633-1 1995 Glutamine synthetase (GS) catalyzes the ATP-dependent condensation of ammonia and glutamate to yield glutamine, ADP, and inorganic phosphate in the presence of divalent cations. Adenosine Diphosphate 112-115 glutamate-ammonia ligase Homo sapiens 0-20 7589510-4 1995 TPO by itself did not cause platelet aggregation and shape change, but augmented ADP-induced aggregation in a dose-dependent manner. Adenosine Diphosphate 81-84 thrombopoietin Homo sapiens 0-3 7559400-0 1995 NAD(+)-dependent ADP-ribosylation of T lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes. Adenosine Diphosphate 17-20 ADP-ribosyltransferase 2b Rattus norvegicus 62-67 7590139-2 1995 Isolated human platelets were used to investigate the effect of atrial natriuretic peptide (ANP) on in vitro platelet aggregation induced by epinephrine, ADP, collagen and 5-hydroxytryptamine. Adenosine Diphosphate 154-157 natriuretic peptide A Homo sapiens 64-90 7590139-2 1995 Isolated human platelets were used to investigate the effect of atrial natriuretic peptide (ANP) on in vitro platelet aggregation induced by epinephrine, ADP, collagen and 5-hydroxytryptamine. Adenosine Diphosphate 154-157 natriuretic peptide A Homo sapiens 92-95 7590139-5 1995 In our experiments ANP inhibited epinephrine- and partially ADP-induced aggregation in vitro and this effect was suggested to be the result of an interaction of the peptide with adenylate cyclase in platelets. Adenosine Diphosphate 60-63 natriuretic peptide A Homo sapiens 19-22 8578535-5 1995 When a range of concentrations of ADP were used to generate an aggregation dose-response curve, the addition of MGDF to platelet rich plasma shifted the dose response curve to the left. Adenosine Diphosphate 34-37 thrombopoietin Homo sapiens 112-116 7559400-1 1995 Rat T lymphocyte alloantigen 6.1 (RT6.1), which was synthesized as the fusion protein with a maltose-binding protein in Escherichia coli, displayed NAD(+)-dependent auto-ADP-ribosylation in addition to an enzyme activity of NAD+ glycohydrolase. Adenosine Diphosphate 170-173 ADP-ribosyltransferase 2b Rattus norvegicus 34-39 7559400-6 1995 These results suggested that the NAD(+)-dependent modification of the 31-kDa protein was due to ADP-ribosylation of glycosylphosphatidylinositol-anchored RT6.1 at an arginine residue. Adenosine Diphosphate 96-99 ADP-ribosyltransferase 2b Rattus norvegicus 154-159 7559400-7 1995 When intact lymphocytes, in which RT6.1 had been once modified by [32P]ADP-ribosylation, were further incubated in the absence of NAD+, there was reduction of the radioactivity in the [32P]ADP-ribosylated RT6.1. Adenosine Diphosphate 71-74 ADP-ribosyltransferase 2b Rattus norvegicus 34-39 7559400-7 1995 When intact lymphocytes, in which RT6.1 had been once modified by [32P]ADP-ribosylation, were further incubated in the absence of NAD+, there was reduction of the radioactivity in the [32P]ADP-ribosylated RT6.1. Adenosine Diphosphate 189-192 ADP-ribosyltransferase 2b Rattus norvegicus 34-39 7559400-10 1995 Moreover, readdition of NAD+ caused the ADP-ribosylation of RT6.1 again. Adenosine Diphosphate 40-43 ADP-ribosyltransferase 2b Rattus norvegicus 60-65 7559400-11 1995 Thus, the ADP-ribosylation of RT6.1 appeared to proceed reversibly in intact rat lymphocytes. Adenosine Diphosphate 10-13 ADP-ribosyltransferase 2b Rattus norvegicus 30-35 7547919-1 1995 The kinetics of nucleotide binding to pyruvate carboxylase have been studied by measuring the fluorescence changes that occur on the binding and release of FTP and FDP, which are fluorescent formycin analogues of ATP and ADP. Adenosine Diphosphate 221-224 pyruvate carboxylase Homo sapiens 38-58 7547923-6 1995 On the other hand, nucleotide-free hsc70 behaved more like hsc70-ADP than hsc70-ATP in that cytochrome c peptide dissociated very slowly from nucleotide-free hsc70 compared to its rapid dissociation from hsc70-ATP. Adenosine Diphosphate 65-68 cytochrome c, somatic Homo sapiens 92-104 8536107-1 1995 We have shown that the cytotoxic response of TNF-sensitive L929 cells and TNF-resistant EMT-6 cells to TNF-alpha can be modulated by ADP-ribosylation inhibitors independently of ADP-ribosylation rates. Adenosine Diphosphate 133-136 tumor necrosis factor Mus musculus 45-48 7669029-5 1995 The IIB vWF-evoked (3 micrograms/ml) cytosolic Ca2+ increase was negligibly affected by ADP scavengers or protein kinase C inhibitors; it was drastically reduced by EGTA, La3+, Ni2+ or acetylsalicylate and abolished by the phospholipase A2 inhibitors ONO-RS-082 or oleolyloxyethyl-phosphocholine. Adenosine Diphosphate 88-91 von Willebrand factor Homo sapiens 8-11 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 118-128 7677179-4 1995 When fluorescein isothiocyanate (FITC)-streptavidin was added to ADP-stimulated platelets 1 minute after biotinylated fibrinogen binding at 22 degrees C, bound fibrinogen was found in variously sized patches on the cell surface. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 160-170 7673245-5 1995 These polymers were much larger than the dimers and trimers of hsp70, which normally form in the presence of ADP. Adenosine Diphosphate 109-112 heat shock 70 kDa protein 1B Bos taurus 63-68 7657615-10 1995 Hyperbolic ATP binding isotherms yield a dissociation constant of 82 microM, about 4-fold weaker than the K0.5 for ATP seen in steady-state kinetics assays of the wild-type GroEL ATPase.A similar difference was seen for ADP binding. Adenosine Diphosphate 220-223 GroEL Escherichia coli 173-178 8536107-1 1995 We have shown that the cytotoxic response of TNF-sensitive L929 cells and TNF-resistant EMT-6 cells to TNF-alpha can be modulated by ADP-ribosylation inhibitors independently of ADP-ribosylation rates. Adenosine Diphosphate 133-136 tumor necrosis factor Mus musculus 74-77 8536107-1 1995 We have shown that the cytotoxic response of TNF-sensitive L929 cells and TNF-resistant EMT-6 cells to TNF-alpha can be modulated by ADP-ribosylation inhibitors independently of ADP-ribosylation rates. Adenosine Diphosphate 133-136 tumor necrosis factor Mus musculus 103-112 7562529-3 1995 Supernatant of platelets (6.0 x 10(8) platelets/ml) aggregated by adenosine diphosphate contained large amounts of TGF-beta 1, but were almost in a latent form, and the proportion of active TGF-beta 1 in the supernatant was increased markedly in the case of acidification or heat treatment. Adenosine Diphosphate 66-87 transforming growth factor beta 1 Homo sapiens 115-125 7768948-8 1995 Moreover, treatment of purified cell membranes with rTIMP-2 suppresses cholera toxin-mediated ADP-ribosylation of the GTP-binding protein, Gs alpha subunit. Adenosine Diphosphate 94-97 GNAS complex locus Homo sapiens 139-147 15374225-5 1995 The shape-associated parameter and the initial rate of 50 microM ADP-induced aggregation of platelets non-activated and activated by cytochrome C are recommended for establishing the diagnosis of Alzheimer"s disease and senile dementia of the Alzheimer-type. Adenosine Diphosphate 65-68 cytochrome c, somatic Homo sapiens 133-145 8948442-3 1995 [32P]ADP ribosylation of RhoA in HL60 homogenates in vitro was reduced to 10-20% when cells in culture were pretreated with C3 exoenzyme (10 micrograms, 24 h), indicating that 80-90% of RhoA could be ADP-ribosylated in situ. Adenosine Diphosphate 5-8 ras homolog family member A Homo sapiens 25-29 8948442-3 1995 [32P]ADP ribosylation of RhoA in HL60 homogenates in vitro was reduced to 10-20% when cells in culture were pretreated with C3 exoenzyme (10 micrograms, 24 h), indicating that 80-90% of RhoA could be ADP-ribosylated in situ. Adenosine Diphosphate 5-8 ras homolog family member A Homo sapiens 186-190 8948442-3 1995 [32P]ADP ribosylation of RhoA in HL60 homogenates in vitro was reduced to 10-20% when cells in culture were pretreated with C3 exoenzyme (10 micrograms, 24 h), indicating that 80-90% of RhoA could be ADP-ribosylated in situ. Adenosine Diphosphate 200-203 ras homolog family member A Homo sapiens 25-29 7789507-1 1995 In the presence of MgATP or MgADP the E. coli chaperonin proteins, GroEL and GroES, form a stable asymmetric complex with a stoichiometry of two GroEL7:one GroES7: seven MgADP. Adenosine Diphosphate 28-33 GroEL Escherichia coli 67-72 7649993-3 1995 Stimulation of the C5a receptor expressed in HEK293 cells results in modest MAP kinase activation, which is inhibited by pertussis toxin-catalyzed ADP-ribosylation of G(i). Adenosine Diphosphate 147-150 complement C5a receptor 1 Homo sapiens 19-31 7638601-3 1995 Association of GroES and subsequent ATP hydrolysis in the interacting GroEL toroid resulted in the formation of a stable GroEL:ADP:GroES complex. Adenosine Diphosphate 127-130 GroEL Escherichia coli 70-75 7638601-3 1995 Association of GroES and subsequent ATP hydrolysis in the interacting GroEL toroid resulted in the formation of a stable GroEL:ADP:GroES complex. Adenosine Diphosphate 127-130 GroEL Escherichia coli 121-126 8524696-6 1995 Platelet aggregation (in PRP according to Born) induced by collagen (2 micrograms/ml), ADP (5 microM), epinephrine (10 microM) arachidonic acid (0.25 mM) and 5-HT (1 microM) was found to be significantly enhanced in diabetic relative to controls. Adenosine Diphosphate 87-90 prion protein Homo sapiens 25-28 7668111-9 1995 CONCLUSION: Thrombin-induced platelet NPY secretion was related to an Ca2+ influx through non-voltage dependent Ca2+ channels and positive feedbacks of arachidonate metabolites or/and released ADP. Adenosine Diphosphate 193-196 coagulation factor II Rattus norvegicus 12-20 8948442-0 1995 ADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells. Adenosine Diphosphate 0-3 ras homolog family member A Homo sapiens 44-48 7789507-4 1995 However, we find that the SPDP-promoted cross linking of GroES and GroEL occurs in the absence of Mg2+, ADP or ATP, which are required for the formation of the asymmetric complex. Adenosine Diphosphate 104-107 GroEL Escherichia coli 67-72 8592522-2 1995 When sonicated nuclei of adrenal capillary endothelial or SK-Hep1 cells are incubated with [32P]NAD, FGF-2 is rapidly ADP-ribosylated in a dose- and time-dependent fashion. Adenosine Diphosphate 118-121 fibroblast growth factor 2 Homo sapiens 101-106 7781604-3 1995 Thrombin-induced phosphorylation of SH-PTP1 is an early signalling event (maximal within 10 s) involving neither integrin signalling, nor calcium, nor release of ADP or thromboxane A2. Adenosine Diphosphate 162-165 coagulation factor II, thrombin Homo sapiens 0-8 7628865-1 1995 Poly(ADPR) polymerase (PARP; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical-induced DNA strand breaks, transfers ADP ribose units to nuclear proteins and initiates apoptosis by depletion of cellular NAD and ATP pools. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 23-27 8592522-8 1995 As such, an immunoreactive ADP-ribosylated FGF-2 is detected in extracts of SK-Hep1 nuclei when they are incubated with [32P]NAD. Adenosine Diphosphate 27-30 fibroblast growth factor 2 Homo sapiens 43-48 8592522-9 1995 Taken together, these findings suggest that the role played by ADP ribosylation in signal transduction, DNA repair, the control of the cell cycle, and cell differentiation may involve its ability to target molecules such as FGF-2. Adenosine Diphosphate 63-66 fibroblast growth factor 2 Homo sapiens 224-229 7738007-5 1995 Purified spinach cpn21 has a ring-like toroidal structure and forms a stable complex with E. coli GroEL in the presence of ADP and is functionally interchangeable with bacterial GroES in the chaperonin-facilitated refolding of denatured ribulose-1,5-bisphosphate carboxylase. Adenosine Diphosphate 123-126 GroEL Escherichia coli 98-103 7737974-13 1995 The enhanced ATP dissociation caused by both polypeptide substrates and Ydj1p may play a role in the regulation of Ssa1p chaperone activity by altering the relative abundance of ATP-and ADP-bound forms. Adenosine Diphosphate 186-189 type I HSP40 co-chaperone YDJ1 Saccharomyces cerevisiae S288C 72-77 7613525-7 1995 Endothelin-1 produced a reduction in the extent of ADP-ribosylation of Gi alpha and this was of similar magnitude in both SHR and WKY cell membranes. Adenosine Diphosphate 51-54 endothelin 1 Rattus norvegicus 0-12 7741112-4 1995 This study examines the capacity of anti-PlAl from patients with PTP and from mothers of infants affected by the NAIT to block the binding of radio-labeled fibrinogen to washed human platelets stimulated by ADP and epinephrine. Adenosine Diphosphate 207-210 fibrinogen beta chain Homo sapiens 156-166 7643919-2 1995 Pieces of vas deferens degraded 83 to 85% of added ATP, ADP and 2-methyl-thio ATP (all 100 microM) over 30 min. Adenosine Diphosphate 56-59 arginine vasopressin Rattus norvegicus 10-13 7900741-8 1995 Fibrinogen was significantly correlated with collagen- and adenosine-diphosphate-induced platelet aggregation and with platelet adherence, spreading, and thrombus formation on subendothelium. Adenosine Diphosphate 59-80 fibrinogen beta chain Homo sapiens 0-10 7763134-6 1995 Everted membrane vesicles catalyzed hydrogen-dependent glyoxylate reduction to glycolate [86-207 nmol min-1 (mg protein)-1] coupled to ATP synthesis from ADP and Pi [38-82 nmol min-1 (mg protein)-1)]. Adenosine Diphosphate 154-157 CD59 molecule (CD59 blood group) Homo sapiens 102-122 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 27-37 7716547-4 1995 The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release. Adenosine Diphosphate 80-83 insulin Homo sapiens 150-157 7884323-4 1995 Formyl peptide receptor number and affinity were not significantly different in CM and TNF-M. Gi and Gs content were increased in TNF-M as measured by pertussis toxin and cholera toxin (CT) catalyzed ADP-ribosylation, respectively. Adenosine Diphosphate 200-203 tumor necrosis factor Homo sapiens 130-133 7706272-7 1995 This AMP was traced to arise from AdK-catalyzed phosphotransfer involving ADP generated by a muscle ATPase. Adenosine Diphosphate 74-77 adenosine kinase Rattus norvegicus 34-37 7852376-1 1995 In previous work we found that bovine brain hsp70 has a single binding site for nucleotide, and that, with ATP at this site, the rates of association and dissociation of clathrin from hsp70 are fast, whereas with ADP at this site, these rates are unmeasurably slow. Adenosine Diphosphate 213-216 heat shock 70 kDa protein 1B Bos taurus 44-49 7852376-3 1995 Second, we show that, with ADP bound to hsp70, as occurs with clathrin, the rate constant for dissociation of peptide markedly decreases compared to the rate constant observed in ATP. Adenosine Diphosphate 27-30 heat shock 70 kDa protein 1B Bos taurus 40-45 7852376-5 1995 Based on these data we propose a model in which substrates of hsp70 bind to and dissociate from the ATP form of the enzyme, while, following ATP hydrolysis, they are locked onto the ATP form of the enzyme, unable to dissociate until ADP is released and ATP rebinds. Adenosine Diphosphate 233-236 heat shock 70 kDa protein 1B Bos taurus 62-67 7624840-5 1995 Mean number of GPIIb/IIIa as determined by flow cytometric assay was approximately 53,8000 and 79,000 on unactivated and ADP-activated platelets respectively. Adenosine Diphosphate 121-124 integrin subunit alpha 2b Canis lupus familiaris 15-20 7794688-8 1995 Both classes of agonist also elicit an increase in the cholera toxin-catalysed ADP-ribosylation of the splice variant forms of Gs alpha and of a polypeptide of 41,000 M(r). Adenosine Diphosphate 79-82 GNAS complex locus Homo sapiens 127-135 7578422-9 1995 Therefore, the dimeric structure of PARP also requires two molecules of bound NAD for efficient ADP-ribose polymerization. Adenosine Diphosphate 96-99 poly(ADP-ribose) polymerase 1 Homo sapiens 36-40 7792747-1 1995 In a suspension of thrombin degranulated platelets (TDP), ADP and epinephrine can induce platelet aggregation, whereas the synthetic agonist of the thromboxane/endoperoxide receptor U46619 causes only shape change. Adenosine Diphosphate 58-61 coagulation factor II, thrombin Homo sapiens 19-27 7792747-3 1995 In this paper, we have measured fibrinogen binding in relation to phospholipase C (PLC) activation and calcium mobilization in TDP activates by ADP, epinephrine and U46619. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 32-42 7792747-4 1995 ADP caused fibrinogen binding in TDP but neither activated PLC nor caused a calcium mobilization. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 11-21 7792747-5 1995 The requirement for ADP in inducing exposure of fibrinogen binding sites was not absolute since the combination of epinephrine and U46619 produced an increase in fibrinogen binding. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 48-58 7792747-5 1995 The requirement for ADP in inducing exposure of fibrinogen binding sites was not absolute since the combination of epinephrine and U46619 produced an increase in fibrinogen binding. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 162-172 7578425-4 1995 Finally, we have evidence that very short oligomers and even monomers of ADP-ribose covalently bound to proteins can be removed by poly(ADP-ribose) glycohydrolase. Adenosine Diphosphate 73-76 poly(ADP-ribose) glycohydrolase Homo sapiens 131-162 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 150-160 8867787-7 1995 These results extend our previous results (Brot et al., 1994) that indicated the formation, at low ATP concentrations, of a labile SP.BiP.ATP complex that, after ATP hydrolysis, resulted in a stable SP.BiP.ADP complex. Adenosine Diphosphate 206-209 growth differentiation factor 10 Homo sapiens 134-137 8867787-7 1995 These results extend our previous results (Brot et al., 1994) that indicated the formation, at low ATP concentrations, of a labile SP.BiP.ATP complex that, after ATP hydrolysis, resulted in a stable SP.BiP.ADP complex. Adenosine Diphosphate 206-209 growth differentiation factor 10 Homo sapiens 202-205 7530278-4 1995 The effect of DEA/NO on the ADP-ribosylation of the predominant target p39 was dose dependent (EC50 = 80 microM). Adenosine Diphosphate 28-31 cyclin-dependent kinase 5, regulatory subunit 2 (p39) Mus musculus 71-74 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Adenosine Diphosphate 99-102 von Willebrand factor Homo sapiens 339-362 21043735-4 1995 There are now at least two systems of platelet activation under intensive study: (a) agonist (e.g. ADP and thrombin) induced platelet activation when fibrinogen is the ligand; this process occurs at low shear forces and is aspirin sensitive; (b) secondly, in marked contrast, at high shear forces, shear itself activates the platelets and von Willebrand"s factor (vWf) is the ligand, and this process is aspirin insensitive. Adenosine Diphosphate 99-102 von Willebrand factor Homo sapiens 364-367 7660136-2 1995 We have investigated the effects of Mg2+ (added to platelet rich plasma [PRP] as 10mM MgCl2 or MgSO4) on the platelet aggregation and actin polymerization that occurs in response to adenosine diphosphate (ADP). Adenosine Diphosphate 182-203 complement component 4 binding protein alpha Homo sapiens 73-76 7527551-6 1994 An exchange of ATP with ADP bound to BiP has also been demonstrated, and the results suggest that the interactions of BiP with ATP resemble those seen with GTP-binding proteins and GTP. Adenosine Diphosphate 24-27 heat shock protein family A (Hsp70) member 5 Homo sapiens 37-40 7701479-0 1995 In vitro effect of endothelin-1 on collagen, and ADP-induced aggregation in human whole blood and platelet rich plasma. Adenosine Diphosphate 49-52 endothelin 1 Homo sapiens 19-31 7701479-1 1995 The effect of ET-1 on ADP- and collagen-induced platelet aggregation in whole blood and platelet rich plasma (PRP) was studied in 39 healthy volunteers. Adenosine Diphosphate 22-25 endothelin 1 Homo sapiens 14-18 7701479-2 1995 Although ET-1 itself did not cause platelet aggregation, a marked enhancement of ADP-induced aggregation after the preincubation with ET-1 for 5 min was observed in whole blood, but not in PRP. Adenosine Diphosphate 81-84 endothelin 1 Homo sapiens 9-13 7701479-2 1995 Although ET-1 itself did not cause platelet aggregation, a marked enhancement of ADP-induced aggregation after the preincubation with ET-1 for 5 min was observed in whole blood, but not in PRP. Adenosine Diphosphate 81-84 endothelin 1 Homo sapiens 134-138 7701479-3 1995 This ET-1 concentration and preincubation time-dependent phenomenon could be demonstrated only at threshold concentrations (5 and 7.5 microM) of ADP and is probably due to an interaction of ET-1 with cells which are involved in the whole blood aggregation, such as polymorphonuclear neutrophils. Adenosine Diphosphate 145-148 endothelin 1 Homo sapiens 5-9 7701479-3 1995 This ET-1 concentration and preincubation time-dependent phenomenon could be demonstrated only at threshold concentrations (5 and 7.5 microM) of ADP and is probably due to an interaction of ET-1 with cells which are involved in the whole blood aggregation, such as polymorphonuclear neutrophils. Adenosine Diphosphate 145-148 endothelin 1 Homo sapiens 190-194 7660157-9 1995 In addition, the IVBT with ADP showed a close correlation to the vWF:RCo activity (r2 = 0.73). Adenosine Diphosphate 27-30 von Willebrand factor Homo sapiens 65-68 7529494-11 1994 In contrast with the behaviour of these venom proteins, the adhesion of ADP-treated platelets to immobilized fibrinogen, fibronectin and vWF was inhibited non-selectively by a range of monoclonal antibodies with specificity for the alpha IIb beta 3 complex. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 109-119 7529494-11 1994 In contrast with the behaviour of these venom proteins, the adhesion of ADP-treated platelets to immobilized fibrinogen, fibronectin and vWF was inhibited non-selectively by a range of monoclonal antibodies with specificity for the alpha IIb beta 3 complex. Adenosine Diphosphate 72-75 fibronectin 1 Homo sapiens 121-132 7529494-11 1994 In contrast with the behaviour of these venom proteins, the adhesion of ADP-treated platelets to immobilized fibrinogen, fibronectin and vWF was inhibited non-selectively by a range of monoclonal antibodies with specificity for the alpha IIb beta 3 complex. Adenosine Diphosphate 72-75 von Willebrand factor Homo sapiens 137-140 7527551-6 1994 An exchange of ATP with ADP bound to BiP has also been demonstrated, and the results suggest that the interactions of BiP with ATP resemble those seen with GTP-binding proteins and GTP. Adenosine Diphosphate 24-27 heat shock protein family A (Hsp70) member 5 Homo sapiens 118-121 7875035-4 1994 Fluorescein-fibrinogen bound to dog platelets with an apparent affinity of 0.31 microM after stimulation with either adenosine-5"-diphosphate (ADP) or plateletactivating factor. Adenosine Diphosphate 117-141 fibrinogen beta chain Homo sapiens 12-22 7702804-8 1994 When stimulated with physiologic agonists ADP and thrombin and with the calcium ionophore ionomycin, a biphasic response consisting of early acidification followed by alkalinization was observed, the second phase not being detectable with ADP. Adenosine Diphosphate 239-242 coagulation factor II, thrombin Homo sapiens 50-58 7875035-4 1994 Fluorescein-fibrinogen bound to dog platelets with an apparent affinity of 0.31 microM after stimulation with either adenosine-5"-diphosphate (ADP) or plateletactivating factor. Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 12-22 7875035-6 1994 Aged platelets were indistinguishable from young platelets with regard to fibrinogen binding in response to ADP. Adenosine Diphosphate 108-111 fibrinogen beta chain Homo sapiens 74-84 7740463-7 1994 Moreover, Mg2+ reduced Fg binding to ADP- or collagen-stimulated platelets as well as surface expression of GMP-140 with an IC50 of approximately 3 mM. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 23-25 7898066-4 1994 NTG, SNP, S-NO-Alb, and S-NO-Cap inhibited ADP-induced platelet aggregation dose dependently. Adenosine Diphosphate 43-46 albumin Homo sapiens 15-18 7727795-5 1994 Both PGD2 and PGJ2 do inhibit ADP-induced platelet aggregation in a dose-dependent manner. Adenosine Diphosphate 30-33 prostaglandin D2 synthase Homo sapiens 5-9 7858143-2 1994 We have previously reported that maximal platelet activation with adenosine diphosphate (100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry. Adenosine Diphosphate 66-87 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 173-176 7947604-5 1994 At micromolar concentrations, TSP18 and TSP28 inhibited the second wave of platelet aggregation and the concomitant release of [14C]5-hydroxytryptamine induced by ADP in citrated platelet-rich plasma as well as aggregation and secretion induced by a low concentration of thrombin in washed platelet suspensions. Adenosine Diphosphate 163-166 coagulation factor II, thrombin Homo sapiens 271-279 7532021-1 1994 Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels appear to be regulated by hydrolysis of ATP and are inhibited by a product of hydrolysis, ADP. Adenosine Diphosphate 162-165 CF transmembrane conductance regulator Homo sapiens 0-51 7532021-1 1994 Cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels appear to be regulated by hydrolysis of ATP and are inhibited by a product of hydrolysis, ADP. Adenosine Diphosphate 162-165 CF transmembrane conductance regulator Homo sapiens 53-57 7986196-6 1994 C5a was less effective than fMLP in enhancing cholera toxin-catalysed ADP-ribosylation of Gi alpha 2 and Gi alpha 3, and LTB4 was ineffective. Adenosine Diphosphate 70-73 complement C5a receptor 1 Homo sapiens 0-3 7986196-6 1994 C5a was less effective than fMLP in enhancing cholera toxin-catalysed ADP-ribosylation of Gi alpha 2 and Gi alpha 3, and LTB4 was ineffective. Adenosine Diphosphate 70-73 formyl peptide receptor 1 Homo sapiens 28-32 7858143-2 1994 We have previously reported that maximal platelet activation with adenosine diphosphate (100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry. Adenosine Diphosphate 100-103 FGR proto-oncogene, Src family tyrosine kinase Homo sapiens 173-176 7882192-3 1994 After 4 weeks of CCl4 treatment, liver ATP, ATP/ADP, and energy status were decreased. Adenosine Diphosphate 48-51 C-C motif chemokine ligand 4 Rattus norvegicus 17-21 7865680-9 1994 The presence of endogenous adenosine diphosphate appears to account, at least in part, for the ability of normal platelets in plasma to adhere to forms of fibrinogen which have only one gamma-chain platelet binding site. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 155-165 7863463-2 1994 DMP 728 demonstrated a potent antiplatelet efficacy in inhibiting ADP-induced platelet aggregation in either human or canine PRP with an IC50 of 0.046 and 0.015 microM, respectively. Adenosine Diphosphate 66-69 prion protein Canis lupus familiaris 125-128 8077368-7 1994 In hypertensive patients, beta-endorphin significantly increased blood viscosity and ADP-induced platelet aggregation, but only the former effect was naloxone-sensitive. Adenosine Diphosphate 85-88 proopiomelanocortin Homo sapiens 26-40 7929031-2 1994 We have observed that ADP displays a two-step inhibition of GroEL-dependent ATP hydrolysis, wherein one-half of the GroEL ATPase sites is strongly inhibited by ADP while the other half is affected very mildly. Adenosine Diphosphate 22-25 GroEL Escherichia coli 60-65 7929031-2 1994 We have observed that ADP displays a two-step inhibition of GroEL-dependent ATP hydrolysis, wherein one-half of the GroEL ATPase sites is strongly inhibited by ADP while the other half is affected very mildly. Adenosine Diphosphate 22-25 GroEL Escherichia coli 116-121 7929031-2 1994 We have observed that ADP displays a two-step inhibition of GroEL-dependent ATP hydrolysis, wherein one-half of the GroEL ATPase sites is strongly inhibited by ADP while the other half is affected very mildly. Adenosine Diphosphate 160-163 GroEL Escherichia coli 60-65 7929031-2 1994 We have observed that ADP displays a two-step inhibition of GroEL-dependent ATP hydrolysis, wherein one-half of the GroEL ATPase sites is strongly inhibited by ADP while the other half is affected very mildly. Adenosine Diphosphate 160-163 GroEL Escherichia coli 116-121 8068950-3 1994 In this panel, 10- to 15-fold differences in basal adenosine triphosphate (ATP) content and adenosine diphosphate (ADP)/ATP ratio were correlated with up to fivefold differences in bcl-2 protein (in human cells) and approximately 25-fold difference in bcl-2 mRNA content (all cell lines). Adenosine Diphosphate 92-113 BCL2 apoptosis regulator Homo sapiens 181-186 8068950-3 1994 In this panel, 10- to 15-fold differences in basal adenosine triphosphate (ATP) content and adenosine diphosphate (ADP)/ATP ratio were correlated with up to fivefold differences in bcl-2 protein (in human cells) and approximately 25-fold difference in bcl-2 mRNA content (all cell lines). Adenosine Diphosphate 115-118 BCL2 apoptosis regulator Homo sapiens 181-186 7523118-7 1994 Upon stimulation of platelets with ADP, the number of binding sites anti-[GPIIIa(631-653)] was reduced 2.8-fold. Adenosine Diphosphate 35-38 integrin subunit beta 3 Homo sapiens 74-80 7523118-8 1994 The binding affinity of anti-[GPIIIa(90-102)] antibodies to the resting and ADP-stimulated platelets differed 4.7-fold, indicating that the stimulation of the platelets with ADP resulted in better exposure of this epitope. Adenosine Diphosphate 76-79 integrin subunit beta 3 Homo sapiens 30-36 7523118-8 1994 The binding affinity of anti-[GPIIIa(90-102)] antibodies to the resting and ADP-stimulated platelets differed 4.7-fold, indicating that the stimulation of the platelets with ADP resulted in better exposure of this epitope. Adenosine Diphosphate 174-177 integrin subunit beta 3 Homo sapiens 30-36 7523118-12 1994 Such inhibition of fibrinogen binding was sufficient to block aggregation of ADP-stimulated platelets by the anti-[GPIIIa(90-102)] antibodies in platelet-rich plasma. Adenosine Diphosphate 77-80 fibrinogen beta chain Homo sapiens 19-29 7523118-12 1994 Such inhibition of fibrinogen binding was sufficient to block aggregation of ADP-stimulated platelets by the anti-[GPIIIa(90-102)] antibodies in platelet-rich plasma. Adenosine Diphosphate 77-80 integrin subunit beta 3 Homo sapiens 115-121 8080266-2 1994 The binding constant was found to be 1.52 x 10(6) M-1 at pH 7.5 and 5 degrees C. The intensity decay of epsilon ADP bound to CS1 was resolved into two components over a narrow range of temperatures. Adenosine Diphosphate 112-115 myozenin 2 Bos taurus 125-128 8080266-4 1994 These data suggest a two-state temperature-sensitive transition of the CS1.epsilon ADP complex. Adenosine Diphosphate 83-86 myozenin 2 Bos taurus 71-74 8062255-1 1994 Poly(ADP-ribose) polymerase (PADPRP) catalyzes the transfer of multiple ADP-ribose units from NAD to nuclear histone and nonhistone proteins, a reaction that appears to be important in the rejoining of DNA strand breaks during DNA repair and replication. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 29-35 8083341-4 1994 To confirm the results of the immunoblot analysis, Gs alpha was quantitated by cholera toxin-dependent [32P]ADP-ribosylation. Adenosine Diphosphate 108-111 GNAS complex locus Homo sapiens 51-59 8083341-5 1994 Levels of erythrocyte [32P]ADP-ribose-Gs alpha from FHP subjects were greater than levels in FHN subjects (236 +/- 28 vs 100 +/- 14, P < 0.001). Adenosine Diphosphate 27-30 GNAS complex locus Homo sapiens 38-46 7898460-1 1994 ADP-ribosylation factors (ARFs) comprise a family of approximately 20 kDa guanine nucleotide-binding proteins that were discovered as one of several cofactors required in cholera toxin-catalyzed ADP-ribosylation of Gs alpha, the guanine nucleotide-binding protein responsible for stimulation of adenylyl cyclase, and was subsequently found to enhance all cholera toxin-catalyzed reactions and to directly interact with, and activate the toxin. Adenosine Diphosphate 0-3 GNAS complex locus Homo sapiens 215-223 7898457-1 1994 Starvation of mouse hepatoma cells for essential amino acids or glucose results in the ADP-ribosylation of the molecular chaperone BiP/GRP78. Adenosine Diphosphate 87-90 heat shock protein 5 Mus musculus 131-134 7898457-1 1994 Starvation of mouse hepatoma cells for essential amino acids or glucose results in the ADP-ribosylation of the molecular chaperone BiP/GRP78. Adenosine Diphosphate 87-90 heat shock protein 5 Mus musculus 135-140 7898463-1 1994 ADP-ribosylation reaction, that is the transfer of the ADP-ribose moiety of NAD+ to acceptor protein, is catalyzed by two classes of ADP-ribosyltransferases, i.e., poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferases. Adenosine Diphosphate 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 164-191 7898464-3 1994 The NO-stimulated, NAD-dependent modification of GAPDH was recently characterized as covalent binding of the whole NAD molecule to the enzyme, not ADP-ribosylation. Adenosine Diphosphate 147-150 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 49-54 7898466-3 1994 Instead, it was a non-competitive inhibitor of beta NAD+ in the ADP-ribose polymerization reaction catalyzed by PARP. Adenosine Diphosphate 64-67 poly(ADP-ribose) polymerase 1 Homo sapiens 112-116 7898472-4 1994 The direction of ADP-ribose chain growth as well as the molecular mechanism of the automodification reaction catalyzed by PARP are described. Adenosine Diphosphate 17-20 poly(ADP-ribose) polymerase 1 Homo sapiens 122-126 8063710-7 1994 In the presence of GTP, recombinant yARF3 protein stimulated cholera toxin-catalyzed auto-ADP-ribosylation. Adenosine Diphosphate 90-93 Arf family GTPase ARF3 Saccharomyces cerevisiae S288C 36-41 7520441-3 1994 The presence of the c-Kit receptor was demonstrated by the specific binding of 125I-KL/SCF to ADP-stimulated platelets. Adenosine Diphosphate 94-97 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 20-25 8045941-0 1994 Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. Adenosine Diphosphate 103-106 coagulation factor II Mus musculus 37-45 7518780-5 1994 Finally, the insulin-induced decrease of platelet aggregability to collagen and ADP was completely blunted when PRP was preincubated with 10 microM of the guanylate cyclase inhibitor methylene blue. Adenosine Diphosphate 80-83 insulin Homo sapiens 13-20 7913555-3 1994 With each subsequent turnover, ATP was hydrolyzed by one ring of GroEL in a quantized manner, completely releasing the adenosine diphosphate and GroES that were tightly bound to the other ring as a result of the previous turnover. Adenosine Diphosphate 119-140 GroEL Escherichia coli 65-70 8051492-1 1994 Platelet membrane glycoproteins Ib (GPIb) and IIb/IIIa (GPIIb/IIIa) bind soluble von Willebrand factor (vWf) after stimulation with ristocetin (GPIb) or with thrombin or ADP (GPIIb/IIIa). Adenosine Diphosphate 170-173 von Willebrand factor Homo sapiens 81-102 8051492-1 1994 Platelet membrane glycoproteins Ib (GPIb) and IIb/IIIa (GPIIb/IIIa) bind soluble von Willebrand factor (vWf) after stimulation with ristocetin (GPIb) or with thrombin or ADP (GPIIb/IIIa). Adenosine Diphosphate 170-173 von Willebrand factor Homo sapiens 104-107 7518455-4 1994 ADP inhibited channel opening by precisely antagonizing the effect of ATP, suggesting that ADP inhibits the CFTR channel by competing with ATP for binding. Adenosine Diphosphate 0-3 CF transmembrane conductance regulator Homo sapiens 108-112 7518455-4 1994 ADP inhibited channel opening by precisely antagonizing the effect of ATP, suggesting that ADP inhibits the CFTR channel by competing with ATP for binding. Adenosine Diphosphate 91-94 CF transmembrane conductance regulator Homo sapiens 108-112 7974388-9 1994 SK&F 106760 produced insurmountable inhibition of adenosine diphosphate-induced platelet aggregation in the presence of constant fibrinogen concentrations, but produced competitive inhibition of the concentration-response curve to fibrinogen in adenosine diphosphate-activated platelets with a Kb of 8.0 +/- 1.0 nM. Adenosine Diphosphate 249-270 fibrinogen beta chain Homo sapiens 235-245 8055911-6 1994 Polymerization of skeletal muscle actin from the complex with thymosin beta 4 by phalloidin is accompanied by the hydrolysis of the actin-bound ATP to ADP. Adenosine Diphosphate 151-154 thymosin beta 4, X-linked Gallus gallus 62-77 8021488-3 1994 Treatment of 3T3 cells with TNF-alpha, in the presence of [adenylate-32P]NAD followed by SDS-PAGE, revealed the involvement of specific ADP-ribosylation of a 90-kDa protein in TNF-alpha-mediated cytotoxicity. Adenosine Diphosphate 136-139 tumor necrosis factor Mus musculus 28-37 7920251-4 1994 Trp-223 is responsible for a strong (18-21%) fluorescence quenching effect occurring upon formation of a transition state-analogue complex (TSAC;Mib-CK.creatine.MgADP.NO3-), and Trp-223 is probably required for the conformational change leading to the TSAC-induced octamer dissociation of Mib-CK. Adenosine Diphosphate 161-166 creatine kinase, mitochondrial 2 Gallus gallus 145-151 8021488-3 1994 Treatment of 3T3 cells with TNF-alpha, in the presence of [adenylate-32P]NAD followed by SDS-PAGE, revealed the involvement of specific ADP-ribosylation of a 90-kDa protein in TNF-alpha-mediated cytotoxicity. Adenosine Diphosphate 136-139 tumor necrosis factor Mus musculus 176-185 8003509-6 1994 (5) ADP induces a concentration-dependent attenuation of the activation of ASCI-PLA2 by ATP. Adenosine Diphosphate 4-7 phospholipase A2 group IB Homo sapiens 75-84 7920251-4 1994 Trp-223 is responsible for a strong (18-21%) fluorescence quenching effect occurring upon formation of a transition state-analogue complex (TSAC;Mib-CK.creatine.MgADP.NO3-), and Trp-223 is probably required for the conformational change leading to the TSAC-induced octamer dissociation of Mib-CK. Adenosine Diphosphate 161-166 creatine kinase, mitochondrial 2 Gallus gallus 289-295 7974361-4 1994 We have examined the effects of the platelet secretagogues ADP, AMP, ATP and serotonin on the release of vWf from ECs and demonstrated enhanced release in all cases. Adenosine Diphosphate 59-62 von Willebrand factor Homo sapiens 105-108 7908986-4 1994 It is also shown that ADP by itself specifically destabilizes the Cys518-->Ser mutant GroEL particle with this effect being suppressed in the double mutant. Adenosine Diphosphate 22-25 GroEL Escherichia coli 89-94 8062509-13 1994 Fibrinogen binding in response to "weak" agonist stimulation, by low concentrations of ADP or, in a subgroup by adrenaline, was in fact lower in the normal pregnant women than in the non-pregnant women. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 0-10 7919168-2 1994 Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. Adenosine Diphosphate 38-41 cyclin dependent kinase 5 regulatory subunit 2 Homo sapiens 98-101 7911090-1 1994 In the presence of ADP, the molecular chaperones GroEL and GroES from Escherichia coli not only facilitated the refolding of various proteins, but also prevented their irreversible heat inactivation in vitro. Adenosine Diphosphate 19-22 GroEL Escherichia coli 49-54 8195155-13 1994 ADP was less active than ATP at initiating the post-translational maturation and release of IL-1 beta and AMP, GTP, and UTP were totally inactive, ATP, nigericin, A204, and lasalocid promoted a rapid and complete loss of the potassium analog 86Rb+ from cells that were preloaded with this cation; valinomycin-treated cells released only a portion of the radiolabeled cation. Adenosine Diphosphate 0-3 interleukin 1 beta Mus musculus 92-101 7909810-0 1994 The effect of groES on the groEL-dependent assembly of dodecameric glutamine synthetase in the presence of ATP and ADP. Adenosine Diphosphate 115-118 GroEL Escherichia coli 27-32 7909810-10 1994 In addition, groES can initiate renaturation of GS from the groEL.GS arrested complex in the presence of ADP. Adenosine Diphosphate 105-108 GroEL Escherichia coli 60-65 7909810-12 1994 Since ATP hydrolysis is not absolutely required, the combined binding energies of groES and ATP (or ADP) appear to be sufficient to weaken the binding affinity of groEL for GS subunits and facilitate the release and refolding of assembly competent GS monomers from groEL. Adenosine Diphosphate 100-103 GroEL Escherichia coli 163-168 7909810-12 1994 Since ATP hydrolysis is not absolutely required, the combined binding energies of groES and ATP (or ADP) appear to be sufficient to weaken the binding affinity of groEL for GS subunits and facilitate the release and refolding of assembly competent GS monomers from groEL. Adenosine Diphosphate 100-103 GroEL Escherichia coli 265-270 8161545-4 1994 Magnesium ion is also required for the activation of Gs, and Gs alpha is a substrate for ADP-ribosylation catalyzed by choleragen (CT). Adenosine Diphosphate 89-92 GNAS complex locus Homo sapiens 61-69 8161545-9 1994 Gs subunit dissociation was accompanied by a corresponding decrease in CT-catalyzed ADP-ribosylation of Gs alpha regardless of whether or not GTP gamma S or fluoroaluminate was bound to Gs alpha. Adenosine Diphosphate 84-87 GNAS complex locus Homo sapiens 104-112 8144525-4 1994 Since RT6.2 has significant amino acid identity with a GPI-anchored rabbit muscle NAD:arginine ADP-ribosyltransferase, RT6.2 was expressed in rat mammary adenocarcinoma cells and the ability of the expressed protein to catalyze ADP-ribose transfer reactions was examined. Adenosine Diphosphate 95-98 ADP-ribosyltransferase 2b Rattus norvegicus 6-11 8144525-4 1994 Since RT6.2 has significant amino acid identity with a GPI-anchored rabbit muscle NAD:arginine ADP-ribosyltransferase, RT6.2 was expressed in rat mammary adenocarcinoma cells and the ability of the expressed protein to catalyze ADP-ribose transfer reactions was examined. Adenosine Diphosphate 95-98 ADP-ribosyltransferase 2b Rattus norvegicus 119-124 8139548-2 1994 Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function. Adenosine Diphosphate 260-263 insulin Homo sapiens 0-7 7914750-0 1994 TNF cytotoxicity: effects of HER-2/neu expression and inhibitors of ADP-ribosylation. Adenosine Diphosphate 68-71 tumor necrosis factor Homo sapiens 0-3 7914750-2 1994 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Adenosine Diphosphate 142-145 erb-b2 receptor tyrosine kinase 2 Homo sapiens 170-175 7914750-2 1994 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Adenosine Diphosphate 142-145 erb-b2 receptor tyrosine kinase 2 Homo sapiens 176-179 7914750-2 1994 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Adenosine Diphosphate 142-145 erb-b2 receptor tyrosine kinase 2 Homo sapiens 231-236 7914750-2 1994 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Adenosine Diphosphate 142-145 erb-b2 receptor tyrosine kinase 2 Homo sapiens 237-240 7914750-2 1994 In short-term 51Cr-release assays with several mouse and human tumor cell lines, the inhibitors aminobenzamide (ABA) and nicotinamide (NA) of ADP-ribosylation sensitized HER-2/neu-nonoverexpressing cells (CaOV-3 and MCF-7) but not HER-2/neu-overexpressing cells (SKOV-3 and SKBR-3) to TNF. Adenosine Diphosphate 142-145 tumor necrosis factor Homo sapiens 285-288 7914750-7 1994 Thus, modulation of TNF sensitivity by these inhibitors might be linked to a compromised repair mechanism distinct from the effects on ADP-ribosylation alone. Adenosine Diphosphate 135-138 tumor necrosis factor Homo sapiens 20-23 8142378-7 1994 When the incubation medium was supplemented with NaF and AlCl3, and maintained in the dark, both 2-azido[3H]ADP and 8-azido[3H]ADP were able to elicit inhibition of F1-ATPase activity, exactly like ADP did. Adenosine Diphosphate 108-111 C-X-C motif chemokine ligand 8 Homo sapiens 49-52 8135199-7 1994 The F(ab")2 of the patient"s IgG had a synergetic effect on the aggregation of PRP induced by adenosine 5-diphosphate. Adenosine Diphosphate 94-117 prion protein Homo sapiens 79-82 8118033-13 1994 The role that G proteins play in mediating the intracellular signaling pathways induced by GM-CSF or IL-2 in human T cells is supported by adenosine diphosphate-ribosylation of a 44-kD or a 39-kD G protein in T-cell membranes by CT and PT, respectively. Adenosine Diphosphate 139-160 interleukin 2 Homo sapiens 101-105 8185716-1 1994 By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation. Adenosine Diphosphate 131-152 kininogen 1 Homo sapiens 50-60 8185716-1 1994 By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation. Adenosine Diphosphate 131-152 coagulation factor II, thrombin Homo sapiens 77-85 8185716-1 1994 By the mediation of receptors in the endothelium, bradykinin, histamine, and thrombin--besides platelet-derived substances such as adenosine diphosphate and triphosphate (ADP, ATP) and serotonin--play an essential physiological role in the activation of the protective metabolic process in the endothelium, which is so important to vessel dilatation. Adenosine Diphosphate 171-174 coagulation factor II, thrombin Homo sapiens 77-85 7519037-2 1994 With maximum ADP (10(-5) M) fibrinogen bound to 76.1 +/- 7.2% of platelets but P-selectin and CD63 antigen were expressed on 26.9 +/- 9.8% and 8.6 +/- 3.5% of platelets respectively. Adenosine Diphosphate 13-16 fibrinogen beta chain Homo sapiens 28-38 7519037-6 1994 Addition of the GPIIb-IIIa antagonist echistatin, at concentrations that totally blocked fibrinogen binding to ADP-stimulated platelets, had no effect on the expression of the granule membrane antigens. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 89-99 8200911-3 1994 Insulin 1 x 10(-9) M (approximately ED50) and 1 x 10(-7) M (Max) inhibited pertussis toxin-catalyzed ADP ribosylation of Gi in human liver plasma membranes from lean and obese nondiabetic patients. Adenosine Diphosphate 101-104 insulin Homo sapiens 0-7 8200911-9 1994 However, a monoclonal antibody to the insulin receptor (MA-20) at equimolar concentrations with insulin equally inhibits pertussis toxin-catalyzed ADP ribosylation of Gi without activating tyrosine kinase or insulin receptor autophosphorylation. Adenosine Diphosphate 147-150 insulin Homo sapiens 38-45 8179202-6 1994 ADP and thrombin stimulated platelet adhesion in a dose-dependent manner to fibrinogen and human plasma, but not to human albumin. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 76-86 8307191-2 1994 ADP-ribose moiety containing digoxigenin was transferred by pertussis toxin (IAP) to the alpha subunit of Gi (Gi alpha) from digoxigenin-conjugated NAD (DIG-NAD) in a beta gamma subunit-dependent manner. Adenosine Diphosphate 0-3 alkaline phosphatase, intestinal Homo sapiens 77-80 8013528-3 1994 Free arachidonate, liberated from phospholipids by phospholipase A2, is rapidly converted (by oxygenation) to prostaglandins and thromboxanes which, together with secreted ADP and close cell contact, will cause further platelet activation through "positive feedback" (autocrine stimulation). Adenosine Diphosphate 172-175 phospholipase A2 group IB Homo sapiens 51-67 8165651-8 1994 Thus, ticlopidine facilitates the deaggregation of thrombin-induced human platelet aggregates, most probably because it inhibits the effects of ADP on platelets. Adenosine Diphosphate 144-147 coagulation factor II, thrombin Homo sapiens 51-59 8274476-3 1994 In contrast, platelets stimulated with 10 mumol/L ADP bound 63 734 +/- 2453 molecules of fibrinogen per platelet. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 89-99 8274476-5 1994 The increased fibrinogen binding in the presence of LDL resulted in faster aggregation with a 16% increase in single platelet disappearance and a faster optical aggregation at 5 mumol/L ADP and 1.5 g protein/L LDL. Adenosine Diphosphate 186-189 fibrinogen beta chain Homo sapiens 14-24 21043742-2 1994 In addition, platelets stored either in Terumo or Baxter (PL 146 and PL 732) plastic bags at room temperature, showed an increased ADP-induced aggregation (10 muM) when studied at room temperature compared to 37 C. This pattern was confirmed by the difference in released ATP during aggregation. Adenosine Diphosphate 131-134 latexin Homo sapiens 159-162 8165650-2 1994 The effect of shear rate and fibrinogen concentration on adenosine diphosphate-induced aggregation of suspensions of washed human platelets in Poiseuille flow at 23 degrees C was studied using a previously described double infusion technique and resistive particle counter size analysis. Adenosine Diphosphate 57-78 fibrinogen beta chain Homo sapiens 29-39 8165651-2 1994 Released adenosine diphosphate (ADP) plays an important role in the stabilization of thrombin-induced human platelet aggregates. Adenosine Diphosphate 9-30 coagulation factor II, thrombin Homo sapiens 85-93 8294438-3 1994 Down-regulation of protein kinase C by phorbol esters or pertussis toxin catalyzed ADP-ribosylation of Gi proteins inhibits thrombin and ATP receptor-stimulated MAP kinase and arachidonic acid release, indicating that functional protein kinase C and Gi proteins are required for G protein regulation of arachidonic acid release. Adenosine Diphosphate 83-86 coagulation factor II, thrombin Homo sapiens 124-132 7762422-7 1994 Inhibition of ADP-induced platelet aggregation by lactotransferrin (50% inhibition = 10 nM) was also found with the N-t fragment of lactotransferrin (residues 3-281; 50% inhibition = 2 microM) and with two synthetic peptides: KRDS tetrapeptide (50% inhibition = 350 microM) and CFQWQRNMRKVRGPPVSC octodecapeptide (50% inhibition = 20 microM) corresponding to the lactotransferrin amino acid sequence 39-42 and 20-37, respectively. Adenosine Diphosphate 14-17 lactotransferrin Homo sapiens 50-66 7762422-7 1994 Inhibition of ADP-induced platelet aggregation by lactotransferrin (50% inhibition = 10 nM) was also found with the N-t fragment of lactotransferrin (residues 3-281; 50% inhibition = 2 microM) and with two synthetic peptides: KRDS tetrapeptide (50% inhibition = 350 microM) and CFQWQRNMRKVRGPPVSC octodecapeptide (50% inhibition = 20 microM) corresponding to the lactotransferrin amino acid sequence 39-42 and 20-37, respectively. Adenosine Diphosphate 14-17 lactotransferrin Homo sapiens 132-148 7762422-7 1994 Inhibition of ADP-induced platelet aggregation by lactotransferrin (50% inhibition = 10 nM) was also found with the N-t fragment of lactotransferrin (residues 3-281; 50% inhibition = 2 microM) and with two synthetic peptides: KRDS tetrapeptide (50% inhibition = 350 microM) and CFQWQRNMRKVRGPPVSC octodecapeptide (50% inhibition = 20 microM) corresponding to the lactotransferrin amino acid sequence 39-42 and 20-37, respectively. Adenosine Diphosphate 14-17 lactotransferrin Homo sapiens 132-148 7506054-3 1994 ADP caused concentration-dependent increases in the percentage of platelets that bound fibrinogen (from 4.4 +/- 0.9% to 69.9 +/- 4.2%) and that expressed P-selectin (from 4.5 +/- 0.5% to 44.2 +/- 3.8%). Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 87-97 8007764-2 1994 Using a Clark-type oxygen electrode we found that electron transport from succinate to oxygen was enhanced by MT whereas ADP-initiated oxygen consumption was inhibited by MT. Adenosine Diphosphate 121-124 metallothionein 1 Rattus norvegicus 171-173 7938756-0 1994 Endothelin-1 potentiates ADP-induced platelet aggregation in chronic renal failure. Adenosine Diphosphate 25-28 endothelin 1 Homo sapiens 0-12 7938756-1 1994 The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF). Adenosine Diphosphate 87-90 endothelin 1 Homo sapiens 60-72 7938756-1 1994 The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF). Adenosine Diphosphate 87-90 endothelin 1 Homo sapiens 74-78 7938756-1 1994 The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF). Adenosine Diphosphate 92-113 endothelin 1 Homo sapiens 60-72 7938756-1 1994 The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF). Adenosine Diphosphate 92-113 endothelin 1 Homo sapiens 74-78 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 0-4 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-2 1994 ET-1 significantly stimulated ADP-induced aggregation in CRF: EC (effective concentration)25 = 2.3 +/- 0.20 with ET-1 vs. 2.7 +/- 0.22 mumol/L without ET-1; EC50: 3.8 +/- 0.18 with ET-1 vs. 4.4 +/- 0.24 mumol/L without ET-1; and EC75: 5.7 +/- 0.22 with ET-1 vs. 6.4 +/- 0.21 mumol/L without ET-1). Adenosine Diphosphate 30-33 endothelin 1 Homo sapiens 113-117 7938756-6 1994 The high endogenous level of ET-1 in CRF patients together with an observed higher endogenous plasma level of cAMP (58 +/- 5.2 nmol/L compared to 29 +/- 2.0 nmol/L in healthy donors) may explain the enhanced pharmacological interaction of ET-1 and ADP in CRF patients. Adenosine Diphosphate 248-251 endothelin 1 Homo sapiens 29-33 8165651-2 1994 Released adenosine diphosphate (ADP) plays an important role in the stabilization of thrombin-induced human platelet aggregates. Adenosine Diphosphate 32-35 coagulation factor II, thrombin Homo sapiens 85-93 8178315-0 1994 Insulin increases the aggregation response of human platelets to ADP. Adenosine Diphosphate 65-68 insulin Homo sapiens 0-7 8260702-10 1993 These results suggest that gelsolin"s severing (and subsequent capping) of actin filaments not only results in an increase in the number of pointed filament ends but also in the dissociation of actin monomers containing ADP. Adenosine Diphosphate 220-223 gelsolin Rattus norvegicus 27-35 8258703-3 1993 PARP, which binds to and is activated by DNA strand breaks, catalyzes the removal of ADP-ribose from NAD+ and poly(ADP-ribosylation) of chromatin-associated acceptor proteins. Adenosine Diphosphate 85-88 poly(ADP-ribose) polymerase 1 Homo sapiens 0-4 8226730-4 1993 Activation of phosphatidylinositide 3-kinase by GTP gamma S is blocked by ADP-ribosylation of endogenous Rho, and Rho shifts to the cytoskeleton in platelets exposed to thrombin. Adenosine Diphosphate 74-77 coagulation factor II, thrombin Homo sapiens 169-177 8253196-1 1993 Bovine tryptophanyl-tRNA synthetase (EC 6.1.1.2) deprived of Zn2+ by chelation with the phosphonate analog of Ap4A hydrolyzed ATP(GTP) to ADP(GDP) although its ability to form tryptophanyl adenylate was impaired. Adenosine Diphosphate 138-141 tryptophanyl-tRNA synthetase 1 Homo sapiens 7-35 8262952-9 1993 The 29-kDa fragment inhibited ADP-induced aggregation of platelets and binding of fibrinogen to activated platelets. Adenosine Diphosphate 30-33 fibrinogen beta chain Homo sapiens 82-92 8241506-5 1993 Platelet exposure to adenosine diphosphate or thrombin, but not A23187 or chymotrypsin, markedly enhanced GPIIb and GPIIIa recovery relative to that observed with unstimulated platelets, or prostaglandin E1-treated platelets. Adenosine Diphosphate 21-42 integrin subunit beta 3 Homo sapiens 116-122 8238012-5 1993 Activation-dependent receptor function of the GP IIb-IIIa complex was studied with 125I-fibrinogen and 125I-vWF binding to washed platelets stimulated with adenosine diphosphate plus epinephrine (10 mumol/L each). Adenosine Diphosphate 156-177 von Willebrand factor Homo sapiens 108-111 7935351-13 1993 A model for switching endogenous calmodulin between alpha, beta and gamma and modulation of ATP binding to alpha as well as Mg2+/ADP binding to beta by calmodulin is presented. Adenosine Diphosphate 129-132 calmodulin 1 Homo sapiens 33-43 7935351-13 1993 A model for switching endogenous calmodulin between alpha, beta and gamma and modulation of ATP binding to alpha as well as Mg2+/ADP binding to beta by calmodulin is presented. Adenosine Diphosphate 129-132 calmodulin 1 Homo sapiens 152-162 8280181-3 1993 Fibrinogen was bound in significantly higher amounts (P < 0.02) to hyperlipidaemic platelets activated by ADP than to control ones (107,112 +/- 16,371 and 45,612 +/- 6495 molecules per platelet, respectively). Adenosine Diphosphate 109-112 fibrinogen beta chain Homo sapiens 0-10 8115992-9 1993 The patients had a significantly higher median percentage of circulating platelets with bound fibrinogen (p < 0.005), but fibrinogen binding was significantly lower (p < 0.02) in response to 10(-5) M ADP, compared to twelve age-matched normal controls. Adenosine Diphosphate 206-209 fibrinogen beta chain Homo sapiens 125-135 8399219-6 1993 However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK. Adenosine Diphosphate 26-31 creatine kinase, mitochondrial 2 Gallus gallus 126-132 8399219-6 1993 However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK. Adenosine Diphosphate 26-31 creatine kinase, mitochondrial 2 Gallus gallus 202-208 8134906-9 1993 Monoclonal antibodies against platelet membrane GPIIb-IIIa, potent inhibitors of ADP-induced fibrinogen binding to platelets, completely inhibited adhesion. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 93-103 8227189-11 1993 Pretreatment of membranes with 0.1 microM vasopressin in the presence of 2.5 mM MgCl2 and 100 microM GTP markedly attenuated this PTX-catalyzed ADP-ribosylation of the protein in a time-dependent manner. Adenosine Diphosphate 144-147 arginine vasopressin Rattus norvegicus 42-53 8391850-4 1993 ADP and adenosine beta, gamma-imidoadenosine 5"-triphosphate, hydrolysis resistant analogues, also increased the binding of CaM kinase II with calmodulin. Adenosine Diphosphate 0-3 calmodulin 1 Homo sapiens 143-153 8392366-7 1993 Both Sf9 ARF and Sf9 rARF 2 stimulated in a GTP-dependent manner cholera toxin-catalyzed ADP-ribosylation. Adenosine Diphosphate 89-92 ADP-ribosylation factor 2 Rattus norvegicus 21-27 8396029-0 1993 ADP-stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP-stimulated platelets. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 15-25 8396029-0 1993 ADP-stimulated fibrinogen binding is necessary for some of the inositol phospholipid changes found in ADP-stimulated platelets. Adenosine Diphosphate 102-105 fibrinogen beta chain Homo sapiens 15-25 8396029-1 1993 ADP-stimulation of washed human platelets suspended in Tyrode/albumin solution containing Ca2+ (2 mM) and fibrinogen (0.4 mg/ml) causes extensive, reversible aggregation without appreciable secretion of granule contents. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 106-116 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 97-107 8396029-6 1993 These results indicate that the early decreases in PtdInsP2 and PtdInsP at 10 s are dependent on fibrinogen binding to the platelets and occur after fibrinogen binding which is activated by ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 149-159 7689939-6 1993 Two antibodies to human P-selectin KC4.1 and AC1.2 crossreacted with canine platelets whose surface binding, in response to agonists thrombin, calcium ionophore (A23187), phorbol esters and ADP, was similar. Adenosine Diphosphate 190-193 selectin P Canis lupus familiaris 24-34 8355460-7 1993 Whole blood platelet aggregation (spontaneous, collagen, and ADP-induced) also increased following EPO, collagen and ADP-induced aggregation, increasing further when EPO was withdrawn. Adenosine Diphosphate 61-64 erythropoietin Homo sapiens 99-102 8355460-7 1993 Whole blood platelet aggregation (spontaneous, collagen, and ADP-induced) also increased following EPO, collagen and ADP-induced aggregation, increasing further when EPO was withdrawn. Adenosine Diphosphate 61-64 erythropoietin Homo sapiens 166-169 8355460-7 1993 Whole blood platelet aggregation (spontaneous, collagen, and ADP-induced) also increased following EPO, collagen and ADP-induced aggregation, increasing further when EPO was withdrawn. Adenosine Diphosphate 117-120 erythropoietin Homo sapiens 166-169 8327504-1 1993 Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Adenosine Diphosphate 153-156 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 40-80 8327504-1 1993 Nitric oxide-stimulated modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by [adenylate-32P]NAD has been interpreted in recent reports as ADP-ribosylation. Adenosine Diphosphate 153-156 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 82-87 8327504-9 1993 These results demonstrate that NO-stimulated modification of GAPDH with NAD is not ADP-ribosylation as previously reported but rather is covalent binding of NAD through a NO-dependent thiol intermediate, possibly providing an example of an unexpected, altered reactivity of a nitrosylated protein. Adenosine Diphosphate 83-86 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 61-66 8490165-3 1993 In this study, we show that platelets activated with either adenosine-5"-diphosphate or epinephrine induce IL-8 secretion by EC. Adenosine Diphosphate 60-84 C-X-C motif chemokine ligand 8 Homo sapiens 107-111 8504856-2 1993 Our studies on the effect of glyceraldehyde-3-phosphate (GA3P), the natural substrate of dehydrogenase activity of GAPDH, indicated GA3P to be another very potent activator of ADP-ribosylation of the enzyme. Adenosine Diphosphate 176-179 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 115-120 8504856-5 1993 Ka for GA3P was at least 50-fold lower and maximal activation was somewhat higher than these values for other aldehydes that were also able to enhance GAPDH ADP-ribosylation in the presence of DTT. Adenosine Diphosphate 157-160 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 151-156 8329564-4 1993 The platelet electrophoretic mobility decreases from -2 (mu-cm)/(V-s) to -0.5 (mu-cm)/(V-s) when the platelet is activated with either 1 microM ADP, 10 microM epinephrine or 0.5 NIH U/ml alpha-thrombin. Adenosine Diphosphate 144-147 coagulation factor II, thrombin Homo sapiens 193-201 8506348-0 1993 Modulation of the interaction between G-actin and thymosin beta 4 by the ATP/ADP ratio: possible implication in the regulation of actin dynamics. Adenosine Diphosphate 77-80 thymosin beta 4 X-linked Homo sapiens 50-65 8506348-4 1993 Kinetic experiments and theoretical calculations demonstrate that this ATP/ADP dependence of T beta 4 affinity for G-actin can generate a mechanism of desequestration of G-actin by ADP, in the presence of physiological concentrations of T beta 4 (approximately 0.1 mM). Adenosine Diphosphate 75-78 thymosin beta 4 X-linked Homo sapiens 93-101 8506348-4 1993 Kinetic experiments and theoretical calculations demonstrate that this ATP/ADP dependence of T beta 4 affinity for G-actin can generate a mechanism of desequestration of G-actin by ADP, in the presence of physiological concentrations of T beta 4 (approximately 0.1 mM). Adenosine Diphosphate 75-78 thymosin beta 4 X-linked Homo sapiens 237-245 8506348-4 1993 Kinetic experiments and theoretical calculations demonstrate that this ATP/ADP dependence of T beta 4 affinity for G-actin can generate a mechanism of desequestration of G-actin by ADP, in the presence of physiological concentrations of T beta 4 (approximately 0.1 mM). Adenosine Diphosphate 181-184 thymosin beta 4 X-linked Homo sapiens 93-101 8506348-4 1993 Kinetic experiments and theoretical calculations demonstrate that this ATP/ADP dependence of T beta 4 affinity for G-actin can generate a mechanism of desequestration of G-actin by ADP, in the presence of physiological concentrations of T beta 4 (approximately 0.1 mM). Adenosine Diphosphate 181-184 thymosin beta 4 X-linked Homo sapiens 237-245 7683206-10 1993 The results suggest three things: (i) that contact sites are probably more frequent in the intact cell than in vitro in the absence of macromolecules, (ii) that the contact preference of hexokinase serves rather the ADP supply of the translocator than the ATP transfer to the enzyme and (iii) that the total cellular hexokinase activity may be regulated by specific binding of the enzyme to the contact sites, either because of a different pore structure or because of additional components exclusively exposed in these sites. Adenosine Diphosphate 216-219 hexokinase 1 Homo sapiens 187-197 7683206-10 1993 The results suggest three things: (i) that contact sites are probably more frequent in the intact cell than in vitro in the absence of macromolecules, (ii) that the contact preference of hexokinase serves rather the ADP supply of the translocator than the ATP transfer to the enzyme and (iii) that the total cellular hexokinase activity may be regulated by specific binding of the enzyme to the contact sites, either because of a different pore structure or because of additional components exclusively exposed in these sites. Adenosine Diphosphate 216-219 hexokinase 1 Homo sapiens 317-327 8387027-6 1993 The cholera toxin-catalyzed ADP-ribosylation of Gs alpha in MCF-7 cell membranes was significantly increased by 72 h of treatment with estradiol. Adenosine Diphosphate 28-31 GNAS complex locus Homo sapiens 48-56 8389297-5 1993 Lactotransferrin inhibits ADP-induced platelet aggregation at concentrations down to 5 nM, which can be reached in the plasma after leukocyte degranulation. Adenosine Diphosphate 26-29 lactotransferrin Homo sapiens 0-16 8484722-3 1993 Like actin, the ADP-ribose-arthrin linkage was sensitive towards hydroxylamine treatment, indicating arginine as the amino acid acceptor. Adenosine Diphosphate 16-19 Actin 79B Drosophila melanogaster 5-10 8476913-8 1993 Thrombin-induced exocytosis had a delay of only 3 s, which was shortened when external CaCl2 or ADP was present. Adenosine Diphosphate 96-99 coagulation factor II, thrombin Homo sapiens 0-8 8385945-2 1993 SDS increased the ADP-ribosylation of recombinant rhoA and human platelet cytosolic proteins maximally at 0.01% whereas higher concentrations of the detergent (> 0.01%) inhibited the ADP-ribosylation. Adenosine Diphosphate 18-21 ras homolog family member A Homo sapiens 50-54 8385945-0 1993 Enhancement of Clostridium botulinum C3-catalysed ADP-ribosylation of recombinant rhoA by sodium dodecyl sulfate. Adenosine Diphosphate 50-53 ras homolog family member A Homo sapiens 82-86 8385945-2 1993 SDS increased the ADP-ribosylation of recombinant rhoA and human platelet cytosolic proteins maximally at 0.01% whereas higher concentrations of the detergent (> 0.01%) inhibited the ADP-ribosylation. Adenosine Diphosphate 186-189 ras homolog family member A Homo sapiens 50-54 8384133-5 1993 Rates of glycogen synthesis were lower in fibroblasts from NIDDM subjects both basally and with maximal insulin stimulation (0.77 +/- 0.11 vs. 0.46 +/- 0.04 pmol.well-1 x h-1 [P < 0.02] and 1.49 +/- 0.26 vs. 0.69 +/- 0.05 pmol.well-1 x h-1 +adP < 0.01]). Adenosine Diphosphate 244-247 insulin Homo sapiens 104-111 8477727-0 1993 Transcriptional control of AAC3 gene encoding mitochondrial ADP/ATP translocator in Saccharomyces cerevisiae by oxygen, heme and ROX1 factor. Adenosine Diphosphate 60-63 Rox1p Saccharomyces cerevisiae S288C 129-133 8385638-6 1993 ADP-induced state 3-respiration related to latent citrate synthase activity as a marker for structurally intact mitochondria was not significantly different in both mitochondrial subtypes. Adenosine Diphosphate 0-3 citrate synthase, mitochondrial Oryctolagus cuniculus 50-66 8392699-0 1993 ADP-dependence of platelet activation induced by a thrombin receptor agonist. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 51-59 8392699-3 1993 The ADP removing enzyme system creatine phosphate/creatine phosphokinase (CP/CPK) and the ADP receptor antagonist ATP alpha S strongly inhibited platelet aggregation in response to low doses of TRA, indicating that TRA-induced platelet aggregation, like thrombin-induced aggregation is an ADP mediated event. Adenosine Diphosphate 4-7 coagulation factor II, thrombin Homo sapiens 254-262 8392699-6 1993 These results confirm that the aggregating effect of alpha-thrombin on human platelets is closely linked to its esterolytic activity at the receptor level and show that this aggregation is an ADP mediated event. Adenosine Diphosphate 192-195 coagulation factor II, thrombin Homo sapiens 59-67 8384448-10 1993 Incubation of platelets with okadaic acid, an inhibitor of phosphatases 1 and 2a, inhibited ADP- and thrombin-induced aggregation; although the reason for this effect is unknown, it is unlikely to involve inhibition of phospholipase C, since formation of diacylglycerol appears to have little involvement in the primary phase of ADP-induced aggregation. Adenosine Diphosphate 329-332 coagulation factor II, thrombin Homo sapiens 101-109 8511877-1 1993 Insulin-stimulated synthesis of plasma membraneous "signal" ATP (psATP) from ADP and P(i) in oxidation coupled with that of NADH was detected in a preparation of plasma membranes from human erythrocytes; psATP was formed at concentrations of 10(-8)-10(-9) M. Effect of medicinal plasmapheresis on ability of erythrocyte membranes to produce psATP was studied. Adenosine Diphosphate 77-80 insulin Homo sapiens 0-7 8497857-0 1993 Fibrinogen internalization by ADP-stimulated blood platelets. Adenosine Diphosphate 30-33 fibrinogen beta chain Homo sapiens 0-10 8497857-2 1993 Interaction of gel filtered, ADP-stimulated human platelets with low (0.05 mg/ml) and high (1 mg/ml) fibrinogen (Fg) was examined by transmission electron microscopy. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 101-111 8424687-7 1993 Moreover, both the 33-kDa and the 40-kDa proteins inhibited fibrinogen binding (at 0.1 microM) to ADP- or thrombin-stimulated platelets with IC50 values in the same concentration range. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 60-70 8497857-2 1993 Interaction of gel filtered, ADP-stimulated human platelets with low (0.05 mg/ml) and high (1 mg/ml) fibrinogen (Fg) was examined by transmission electron microscopy. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 113-115 8497857-13 1993 These results indicate on different ultimate fates of exogenous Fg processed by the ADP-stimulated platelets. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 64-66 8382051-9 1993 This kinase probably corresponds to CaM kinase III and the 102 kDa peptide to elongation factor 2 (EF-2), since the 102 kDa peptide was shown to undergo ADP-ribosylation in the presence of diphtheria toxin and NAD+. Adenosine Diphosphate 153-156 eukaryotic translation elongation factor 2 Rattus norvegicus 78-97 8382051-9 1993 This kinase probably corresponds to CaM kinase III and the 102 kDa peptide to elongation factor 2 (EF-2), since the 102 kDa peptide was shown to undergo ADP-ribosylation in the presence of diphtheria toxin and NAD+. Adenosine Diphosphate 153-156 eukaryotic translation elongation factor 2 Rattus norvegicus 99-103 8416943-2 1993 In the immobilized, single platelets, ADP and low doses of thrombin evoked repetitive spikes of [Ca2+]i, whereas higher thrombin concentrations gave elevated plateaus in [Ca2+]i. Stimulation of the cells with thrombin after the addition of ADP changed the frequency of spiking, but not the maximal levels of [Ca2+]i reached. Adenosine Diphosphate 240-243 coagulation factor II, thrombin Homo sapiens 59-67 8380163-5 1993 However, G2A Gs alpha was a poor substrate for cholera toxin-catalyzed ADP-ribosylation either in the soluble form or when membrane-associated. Adenosine Diphosphate 71-74 GNAS complex locus Homo sapiens 13-21 8426076-4 1993 Compared with that of control platelets in buffer containing 1 mmol/L Mg+2, fibrinogen binding to adenosine diphosphate- or thrombin-stimulated platelets decreased 23% +/- 12% and 15% +/- 9% (mean +/- SD, n = 4), respectively, after addition of 1 mmol/L Mn+2. Adenosine Diphosphate 98-119 fibrinogen beta chain Homo sapiens 76-86 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 77-87 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 98-108 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 98-108 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 58-68 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 8426076-6 1993 Ethylenediaminetetraacetic acid dissociated 68% +/- 8% of fibrinogen bound to ADP-treated platelets (p < 0.05) during a 60-minute incubation with fibrinogen and 1 mmol/L Mn+2, compared with 40% +/- 13% of fibrinogen bound to control platelets and 29% +/- 8% of fibrinogen bound in the presence of Ca+2 (mean +/- SD, n = 6). Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 7684867-3 1993 These results also suggest that the intracellular ATP/ADP ratio may be more important than the absolute concentration of ATP in regulating CFTR. Adenosine Diphosphate 54-57 CF transmembrane conductance regulator Homo sapiens 139-143 21043754-5 1993 On the other hand Trovati et al(4) found reduced platelet aggregation responses to ADP, PAF, epinephrine, collagen and arachidonate in the presence of 40 microU/ml insulin. Adenosine Diphosphate 83-86 insulin Homo sapiens 164-171 17831643-1 1992 In the final preparation of the manuscript of our report "Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains" (18 Sept., p. 1701) (1), we inadvertently plotted the data for figure 1C with an incorrect x axis: MgATP was plotted on the x axis instead of P(o). Adenosine Diphosphate 80-83 CF transmembrane conductance regulator Homo sapiens 87-91 8303598-5 1993 ADP-induced platelet aggregation, blood fibrinogen levels got reduced. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 40-50 1472031-0 1992 Triflavin, an RGD-containing antiplatelet peptide, binds to GpIIIa of ADP-stimulated platelets. Adenosine Diphosphate 70-73 integrin subunit beta 3 Homo sapiens 60-66 1460024-3 1992 Here we show that Pasteurella multocida toxin, a potent growth factor for cultured fibroblasts, decreased the ADP-ribosylation of GRP78/BiP to 16 +/- 6% of the control value (n = 23). Adenosine Diphosphate 110-113 heat shock protein 5 Mus musculus 130-135 1460024-3 1992 Here we show that Pasteurella multocida toxin, a potent growth factor for cultured fibroblasts, decreased the ADP-ribosylation of GRP78/BiP to 16 +/- 6% of the control value (n = 23). Adenosine Diphosphate 110-113 heat shock protein 5 Mus musculus 136-139 1460024-5 1992 Bombesin and platelet-derived growth factor (PDGF) similarly decreased the ADP-ribosylation of GRP78/BiP (ED50 0.5 nM and 2.5 ng/ml, respectively) but acted more rapidly than the toxin. Adenosine Diphosphate 75-78 heat shock protein 5 Mus musculus 95-100 1460024-5 1992 Bombesin and platelet-derived growth factor (PDGF) similarly decreased the ADP-ribosylation of GRP78/BiP (ED50 0.5 nM and 2.5 ng/ml, respectively) but acted more rapidly than the toxin. Adenosine Diphosphate 75-78 heat shock protein 5 Mus musculus 101-104 1460024-6 1992 Signaling pathways activated by the toxin, bombesin, and PDGF had effects on the ADP-ribosylation of GRP78/BiP. Adenosine Diphosphate 81-84 heat shock protein 5 Mus musculus 101-106 1460024-6 1992 Signaling pathways activated by the toxin, bombesin, and PDGF had effects on the ADP-ribosylation of GRP78/BiP. Adenosine Diphosphate 81-84 heat shock protein 5 Mus musculus 107-110 1460024-8 1992 Agents that mobilize Ca2+ from the endoplasmic reticulum (A23187, ionomycin, and thapsigargin) caused a decrease in the ADP-ribosylation of GRP78/BiP that was similar in magnitude to that achieved by the toxin, bombesin, and PDGF, implicating a role for inositol 1,4,5-trisphosphate-mediated Ca2+ mobilization in the action of the mitogenic agents. Adenosine Diphosphate 120-123 heat shock protein 5 Mus musculus 140-145 1460024-8 1992 Agents that mobilize Ca2+ from the endoplasmic reticulum (A23187, ionomycin, and thapsigargin) caused a decrease in the ADP-ribosylation of GRP78/BiP that was similar in magnitude to that achieved by the toxin, bombesin, and PDGF, implicating a role for inositol 1,4,5-trisphosphate-mediated Ca2+ mobilization in the action of the mitogenic agents. Adenosine Diphosphate 120-123 heat shock protein 5 Mus musculus 146-149 1446623-3 1992 Treatment of isolated rat adipocytes with insulin inhibited pertussis toxin-catalyzed ADP-ribosylation of a 41-kDa G-protein in subsequently isolated plasma membranes by 30.2 +/- 3.0% and in partially purified insulin receptor preparations by 35.6 +/- 5.7%. Adenosine Diphosphate 86-89 insulin Homo sapiens 42-49 1446623-10 1992 Furthermore, addition of G-protein-depleted insulin receptors to the fraction containing partially purified 41- and 67-kDa G-proteins enhances pertussis toxin-catalyzed ADP-ribosylation of the 41-kDa G-protein. Adenosine Diphosphate 169-172 insulin Homo sapiens 44-51 1332781-6 1992 The specific activity of the purified TPK, which was obtained as a single protein, was 720 nmol TDP formed/mg protein per h at 37 degrees C. A partially purified AK1 preparation catalyzed the formation of TTP from TDP (specific activity, 170 nmol/mg protein per h at 37 degrees C) in addition to its proper reaction to form ATP from ADP. Adenosine Diphosphate 333-336 adenylate kinase 1 Homo sapiens 162-165 1475529-3 1992 The IC50 of A-1 in in vitro ADP- and PAF-induced platelet aggregation was 44.5 microM and 21.2 microM, respectively. Adenosine Diphosphate 28-31 brain protein 1 Mus musculus 12-15 1332781-7 1992 After incubation of the purified TPK and AK1 with 20 microM thiamin in the presence of ATP, ADP and Mg2+ at 37 degrees C for 48 h, the amounts of TDP and TTP synthesized were 465 and 54.0 pmol/250 microliters reaction mixture, respectively. Adenosine Diphosphate 92-95 adenylate kinase 1 Homo sapiens 41-44 1457268-13 1992 192C86 (0.007-0.058 micrograms kg-1 min-1) inhibited platelet aggregation to ADP and collagen both in PRP and WB in a dose-dependent manner. Adenosine Diphosphate 77-80 CD59 molecule (CD59 blood group) Homo sapiens 36-41 1489833-0 1992 [Inhibiting effect of ADP-ribosylation by pertussis toxin on passive transport of Ca2+ into the cell membrane of porcine myometrium]. Adenosine Diphosphate 22-25 carbonic anhydrase 2 Sus scrofa 82-85 1446679-0 1992 Characterization of a nitric-oxide-catalysed ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase. Adenosine Diphosphate 45-48 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 65-105 1446679-2 1992 In order to obtain insight into the sequence of events leading to ADP-ribosylation of GraPDH, we studied the target amino acid, the nucleotide cofactor requirement, pH dependency and the stoichiometry of the reaction. Adenosine Diphosphate 66-69 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 86-92 1446679-4 1992 Furthermore, the radiolabel of auto-[32P]ADP-ribosylated GraPDH is removed by treatment with HgCl2, suggesting an ADP-ribose-cysteine bond. Adenosine Diphosphate 41-44 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 57-63 1446679-4 1992 Furthermore, the radiolabel of auto-[32P]ADP-ribosylated GraPDH is removed by treatment with HgCl2, suggesting an ADP-ribose-cysteine bond. Adenosine Diphosphate 114-117 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 57-63 1385393-8 1992 The dependence of the degree of phosphorylation of insulin receptor on the ATP:ADP ratio may provide a mechanism for modulating the cellular response to insulin. Adenosine Diphosphate 79-82 insulin Homo sapiens 51-58 1328205-3 1992 The EGFR-TK inhibitors App(NH)p (5"-adenylyl-beta, gamma-imidodiphosphate) and ADP were competitive with ATP and noncompetitive with GAT. Adenosine Diphosphate 79-82 epidermal growth factor receptor Homo sapiens 4-8 1409644-7 1992 ADP-ribosylation appears to involve the cysteine where NAD interacts with GAPDH so that ADP-ribosylation likely inhibits enzymatic activity. Adenosine Diphosphate 0-3 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 74-79 1483745-5 1992 Glutamate will subsequently react with ammonia, generated in the AMP deaminase reaction or by deamination of amino acids, under formation of glutamine in a reaction catalysed by glutamine synthetase (glutamate + ammonia + ATP--> glutamine + ADP). Adenosine Diphosphate 244-247 glutamate-ammonia ligase Homo sapiens 178-198 1325373-1 1992 The reversible autophosphorylation of the pp60c-src family tyrosine kinase, p56lyn has been characterized by a simple procedure that involves the examination of the enzyme catalyzed radioisotope exchange between ATP and ADP. Adenosine Diphosphate 220-223 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 76-82 1382316-0 1992 Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains. Adenosine Diphosphate 22-25 CF transmembrane conductance regulator Homo sapiens 29-33 1440531-1 1992 Aggregation, secretion and 47kDa protein (P47) phosphorylation by various agonists such as thrombin, ADP and ionophore A23187 were markedly reduced in platelets from stroke-prone spontaneously hypertensive rats (SHRSP) compared with those of age-matched Wistar Kyoto rat (WKY) platelets, suggesting defective functions of intracellular Ca2+ in SHRSP platelets (Tomita et al. Adenosine Diphosphate 101-104 NSFL1 cofactor Rattus norvegicus 42-45 1355477-8 1992 Surprisingly, the release of tryptophanase from GroEL was facilitated in the presence of ADP as well. Adenosine Diphosphate 89-92 GroEL Escherichia coli 48-53 1325373-3 1992 GDP was capable of substituting for ADP as phosphate acceptor so that p56lyn displayed a nucleoside diphosphate kinase activity. Adenosine Diphosphate 36-39 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 70-76 1355477-9 1992 We concluded that the binding of nucleotides such as ATP and ADP changed the conformation of GroEL and facilitated the dissociation of tryptophanase molecules. Adenosine Diphosphate 61-64 GroEL Escherichia coli 93-98 1355374-8 1992 Exogenous fibrinogen strongly enhanced the effects of ADP and U 46619. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 10-20 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 85-95 1440503-7 1992 Costimulation of platelets with ZnCl2 and thrombin or ZnCl2 and ADP enhanced overall fibrinogen binding but not the EDTA-resistant component, and prevented the recovery of irreversibly bound fibrinogen with the Triton X-100 insoluble cytoskeleton. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 191-201 1519672-3 1992 The current study used standardized stereology in conjunction with immunogold electron microscopy to correlate the initial morphologic changes with fibrinogen receptor localization on the surfaces of ADP-activated human platelets. Adenosine Diphosphate 200-203 fibrinogen beta chain Homo sapiens 148-158 1352448-5 1992 Purified turkey erythrocyte PLC is activated in an adenosine 5"-[beta-thio]diphosphate (ADP[S]; a P2y-purinergic-receptor agonist)- or isoprenaline-regulated manner when reconstituted with turkey erythrocyte ghosts, demonstrating that a single species of PLC effector enzyme can be regulated by both the purinergic and the beta-adrenergic receptor populations present in turkey erythrocyte membranes. Adenosine Diphosphate 88-91 P2Y purinoceptor 1 Meleagris gallopavo 98-121 1470606-6 1992 ATP synthesis from ADP by myokinase was about 13 nmol/mg/min, whereas ADP hydrolysis reached values around 500 to 550 nmol/mg/min, indicating that a myokinase-H+ATPase combination could not account for the observed rates of ADP hydrolysis. Adenosine Diphosphate 19-22 adenylate kinase 1 Homo sapiens 26-35 1412224-7 1992 Thrombin, and to a less extent ADP, increased the binding of FITC-conjugated fibrinogen to normal platelets but had no significant effect on the expression of GPIIIa. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 77-87 1639823-7 1992 VSP alpha/beta cleaved phosphoenolpyruvate, ATP, ADP, PPi, and polyphosphates most efficiently. Adenosine Diphosphate 49-52 stem 28 kDa glycoprotein Glycine max 0-9 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 61-71 1602006-6 1992 ADP-stimulated platelets bound markedly reduced amounts of soluble fibrinogen and platelet adhesion to surface-bound fibrinogen was defective. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 67-77 1602006-6 1992 ADP-stimulated platelets bound markedly reduced amounts of soluble fibrinogen and platelet adhesion to surface-bound fibrinogen was defective. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 117-127 1587839-0 1992 Human growth hormone enhances pertussis toxin-stimulated ADP-ribosylation of Gi in Nb2 cell membrane. Adenosine Diphosphate 57-60 growth hormone 1 Homo sapiens 6-20 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 114-135 fibrinogen beta chain Homo sapiens 205-215 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 61-71 1586714-0 1992 Characterization of the gamma chain platelet binding site on fibrinogen fragment D. Glycoprotein (GP) IIb/IIIa on adenosine diphosphate (ADP)-activated human platelets interacts with specific sites on the fibrinogen molecule leading to aggregation. Adenosine Diphosphate 137-140 fibrinogen beta chain Homo sapiens 205-215 1559973-6 1992 However, after an 18-h pretreatment with PT, which produced ADP-ribosylation of the total complement of PT-sensitive G proteins, the thrombin-induced peak Ca2+ response was inhibited by approximately 72%, suggesting that the major fraction of the Ca2+ response was mediated by a slowly ribosylating component. Adenosine Diphosphate 60-63 coagulation factor II Rattus norvegicus 133-141 1394639-3 1992 The enzyme catalyzed the hydrolysis of adenosine 5"-triphosphate, adenosine 5"-diphosphate, thiamine pyrophosphate, inorganic pyrophosphate, and phosphoprotein such as casein and phosvitin, but not of several phosphomonoesters, except for p-nitrophenyl phosphate and o-phosphotyrosine. Adenosine Diphosphate 66-90 casein kinase 2 beta Rattus norvegicus 179-188 1533430-16 1992 These data demonstrate significant pro-inflammatory activities of extracellular adenine nucleotides during anti-Thy1 GN suggesting an anti-inflammatory role for glomerular ATP/ADPase, which in concert with 5" nucleotidase converts ATP and ADP to antiinflammatory ADO. Adenosine Diphosphate 176-179 Thy-1 cell surface antigen Rattus norvegicus 112-116 1312937-12 1992 In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. Adenosine Diphosphate 39-42 tumor necrosis factor Homo sapiens 101-104 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 127-148 fibrinogen beta chain Homo sapiens 40-50 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 127-148 fibrinogen beta chain Homo sapiens 163-173 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 150-153 fibrinogen beta chain Homo sapiens 40-50 1562729-1 1992 Progressive decreases in platelet-bound fibrinogen accessibility to antibody and enzymes were recently reported to occur after adenosine diphosphate (ADP)-induced fibrinogen binding. Adenosine Diphosphate 150-153 fibrinogen beta chain Homo sapiens 163-173 1562729-5 1992 Pretreatment of ADP-stimulated platelets with chymotrypsin largely prevented the progressive loss of platelet aggregability and the accompanying decreased recognition of bound fibrinogen by antifibrinogen F(ab")2 fragments. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 176-186 1562729-6 1992 Preincubation of platelets with cytochalasin D (30 micrograms/mL) also inhibited the decrease in platelet aggregation after exposure of ADP-treated platelets to fibrinogen over a 60-minute time course. Adenosine Diphosphate 136-139 fibrinogen beta chain Homo sapiens 161-171 1313699-1 1992 Incubation of platelets from normal volunteers, who had not taken any medication at least for 2 weeks, with insulin (200 mu units/ml), resulted in the inhibition of the potentiation of ADP-induced platelet aggregation in the presence of (-)-epinephrine by 50-60% when compared with the control. Adenosine Diphosphate 185-188 insulin Homo sapiens 108-115 1312801-2 1992 The CCl4 treatment decreased the ADP-stimulated oxygen consumption, respiratory control, and ADP/O values, mainly for substrates oxidation of site I, in isolated mitochondria. Adenosine Diphosphate 33-36 C-C motif chemokine ligand 4 Rattus norvegicus 4-8 1312801-2 1992 The CCl4 treatment decreased the ADP-stimulated oxygen consumption, respiratory control, and ADP/O values, mainly for substrates oxidation of site I, in isolated mitochondria. Adenosine Diphosphate 93-96 C-C motif chemokine ligand 4 Rattus norvegicus 4-8 1575681-2 1992 Some fibrinogen-bound platelets showed repetitive spiking in [Ca2+]i with a mean frequency of about 2/min, which increased to 5/min in the presence of ADP. Adenosine Diphosphate 151-154 fibrinogen beta chain Homo sapiens 5-15 1633270-12 1992 plasma by adsorption and elution from paraformaldehyde-fixed normal platelets or electrophoretically separated GP IIIa was an inhibitor of ADP-induced platelet aggregation. Adenosine Diphosphate 139-142 integrin subunit beta 3 Homo sapiens 111-118 1312937-12 1992 In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. Adenosine Diphosphate 39-42 tumor necrosis factor Homo sapiens 170-173 1312937-12 1992 In contrast, pertussis toxin-catalyzed ADP ribosylation experiments suggest a functional coupling of TNF receptors to a 40-kDa pertussis toxin-sensitive G-protein in the TNF-sensitive MCF78 cell line but not in the TNF-resistant MDA MB 231 cell line. Adenosine Diphosphate 39-42 tumor necrosis factor Homo sapiens 170-173 1499407-7 1992 It was found that the plasma vWF correlated with platelet aggregation induced by ADP constantly, but not with other risk factors. Adenosine Diphosphate 81-84 von Willebrand factor Homo sapiens 29-32 1543755-6 1992 Thrombin induced a rapid and transient increase in the intracellular Ca2+ concentration ([Ca2+]i) within 1 min, attenuated pertussis toxin-catalyzed ADP-ribosylation of Gi2 in the membrane, and caused the subsequent translocation of Gi2 alpha. Adenosine Diphosphate 149-152 coagulation factor II Mus musculus 0-8 1317440-12 1992 Thrombin-induced responses lacked the initial sharp peak observed in ADP-induced responses, and caused a sustained response. Adenosine Diphosphate 69-72 coagulation factor II Mus musculus 0-8 1737063-9 1992 (3) Ammonium sulfate addition altered the product inhibition pattern of ADP versus angiotensin II, suggesting that an enzyme-angiotensin II-ADP complex can form in the presence of (NH4)2SO4 but not in its absence. Adenosine Diphosphate 72-75 angiotensinogen Homo sapiens 125-139 1309427-1 1992 Previous studies have shown that binding sites for fibrinogen on platelets stimulated with platelet-activating factor (PAF), adenosine diphosphate or epinephrine rapidly close in the absence of fibrinogen. Adenosine Diphosphate 125-146 fibrinogen beta chain Homo sapiens 51-61 1309800-1 1992 In the presence of hexokinase, vesicles derived from the sarcoplasmic reticulum of skeletal muscle are able to accumulate Ca2+ in a medium containing ADP and glucose 6-phosphate. Adenosine Diphosphate 150-153 hexokinase 1 Homo sapiens 19-29 1613983-5 1992 Concentrations of act PAI, PAI ant and tPA/PAI complex dose-dependently increased with ADP. Adenosine Diphosphate 87-90 plasminogen activator, tissue type Homo sapiens 39-42 1730631-11 1992 6) A high-affinity fMLP binding to HL-60 cell membranes was more effectively reconstituted with the ADP-ribosylated Gi-2 than with the unmodified protein. Adenosine Diphosphate 100-103 formyl peptide receptor 1 Homo sapiens 19-23 1730631-12 1992 These results suggested that the agonist-fMLP receptor complex was effectively coupled with the ADP-ribosylated Gi-2, resulting in the GTP-bound form, and that the hydrolysis of GTP on the modified alpha-subunit was selectively attenuated. Adenosine Diphosphate 96-99 formyl peptide receptor 1 Homo sapiens 41-54 1370607-7 1992 The change was indicative of the receptor"s ability to form an enzyme-angiotensin II-ADP ternary complex in the presence of protamine but not in its absence. Adenosine Diphosphate 85-88 angiotensinogen Homo sapiens 70-84 1316186-3 1992 Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate. Adenosine Diphosphate 120-144 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-70 1530814-8 1992 The ADP scavengers apyrase and CP/CK each prevented the [Ca2+]i increase, and aggregation caused by plasmin or rt-PA, and also prevented their inhibitory effects on thrombin-induced activation. Adenosine Diphosphate 4-7 coagulation factor II, thrombin Homo sapiens 165-173 1316186-3 1992 Superoxide radical was generated from the reaction of H2O2 with Co(II), but was inhibited when Co(II) was chelated with adenosine 5"-diphosphate or citrate. Adenosine Diphosphate 120-144 mitochondrially encoded cytochrome c oxidase II Homo sapiens 95-101 1790144-4 1991 IL-2-induced platelet secretion was quantified by radioimmunoassay (RIA) of PF4, BTG, and TXB2 independent of the addition of an aggregating agonist (ADP). Adenosine Diphosphate 150-153 interleukin 2 Homo sapiens 0-4 1935970-0 1991 Ca2+ ionophore A23187 and thrombin inhibit the pertussis-toxin-induced ADP-ribosylation of the alpha-subunit of the inhibitory guanine-nucleotide-binding protein and other proteins in human platelets. Adenosine Diphosphate 71-74 coagulation factor II, thrombin Homo sapiens 26-34 1935970-6 1991 When the ADP-ribosylation reaction was carried out in platelet membranes, a decrease in ADP ribosylation was still observed after stimulation of platelets with thrombin, but not with A23187. Adenosine Diphosphate 9-12 coagulation factor II, thrombin Homo sapiens 160-168 1935970-6 1991 When the ADP-ribosylation reaction was carried out in platelet membranes, a decrease in ADP ribosylation was still observed after stimulation of platelets with thrombin, but not with A23187. Adenosine Diphosphate 88-91 coagulation factor II, thrombin Homo sapiens 160-168 1928349-5 1991 The addition of glucose (5 mM) and hexokinase (15 U/ml), which results in an increase of ADP due to the phosphorylation of glucose in the medium, caused an increase of free calcium concentration to a new set point of approximately 400 nM. Adenosine Diphosphate 89-92 hexokinase-2 Oryctolagus cuniculus 16-45 1833176-1 1991 Glucose-induced insulin secretion is impaired in rats with chronic renal failure (CRF), and this defect is due to PTH-induced derangement in the metabolism of pancreatic islets, including an elevated basal level of intracellular calcium, low basal ATP content, low glucose-stimulated ATP and ATP/ADP ratio, and decreased maximum velocity of Ca(2+)-ATPase. Adenosine Diphosphate 296-299 parathyroid hormone Rattus norvegicus 114-117 1451594-4 1992 When platelets were stimulated with ADP, calcium ionophore A23187, or thrombin, fibrinogen binding to the platelet surface increased markedly. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 80-90 1324505-11 1992 These data indicate that TNF-alpha does not induce changes in [Ca2+]i nor in membrane potential of HPPMN, and that TNF-alpha-primed FMLP-induced O.2- generation of HPPMN is coupled with ADP-ribosylation and activation of G-proteins, and that protein kinases, especially TK, seem to exert an important role in the priming action of TNF. Adenosine Diphosphate 186-189 tumor necrosis factor Homo sapiens 115-124 1762085-7 1991 By itself, Gly-Arg-Gly-Asp-Ser-Pro specifically caused dose- and time-dependent deaggregation of platelet aggregates formed by ADP or by thrombin in the presence of 1 mM Gly-Pro-Arg-Pro, but had no effect on the dissociation of thrombin-induced platelet-rich fibrin clots. Adenosine Diphosphate 127-130 coagulation factor II, thrombin Homo sapiens 228-236 1659820-0 1991 Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. Adenosine Diphosphate 49-52 GNAS complex locus Homo sapiens 0-8 1659820-0 1991 Gs alpha availability to cholera toxin-catalysed ADP-ribosylation is decreased in membranes of retinoic acid-treated leukemic cell lines HL-60 and THP-1. Adenosine Diphosphate 49-52 GLI family zinc finger 2 Homo sapiens 147-152 1912564-18 1991 This abnormal fibrinogen supports adenosine diphosphate-induced platelet aggregation in a normal manner. Adenosine Diphosphate 34-55 fibrinogen beta chain Homo sapiens 14-24 1897514-1 1991 We compared the reproducibility and temporal stability of ADP-induced aggregation of platelet-rich plasma anticoagulated with citrate or with D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone (PPACK), a thrombin inhibitor. Adenosine Diphosphate 58-61 coagulation factor II, thrombin Homo sapiens 207-215 1746004-5 1991 In addition the functional significance of the binding sites was studied by evaluating the response of GFP from the two experimental groups by assessing the effects of increasing concentrations of added fibrinogen on the response to 10 microM ADP using standard light transmission aggregometry. Adenosine Diphosphate 243-246 fibrinogen beta chain Homo sapiens 203-213 1907272-4 1991 Fibrinogen, RGDF peptide, and the fibrinogen phi chain decapeptide LGGAKQAGDV inhibited the binding of AC7 to ADP-stimulated platelets. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 34-44 1888330-6 1991 Halysin concentration-dependently inhibited the 125I-fibrinogen binding to ADP-stimulated platelets in a competitive manner (IC50 = 0.16 microM). Adenosine Diphosphate 75-78 fibrinogen beta chain Homo sapiens 53-63 1859366-4 1991 Moreover, the LPS-enhanced GTPase activity was not antagonized by phosphatase/ATPase inhibitors such as p-nitrophenyl phosphate, ouabain, bafilomycin or N-ethylmaleimide, and in fact was potentiated by the addition of ATP or ADP. Adenosine Diphosphate 225-228 toll-like receptor 4 Mus musculus 14-17 1829631-2 1991 In concordance with this finding, supernatants from the patients" fibrin clots caused abnormal enhancement of platelet aggregation, ATP secretion, and binding of 125I-fibrinogen to platelets exposed to subthreshold concentrations of ADP or epinephrine. Adenosine Diphosphate 233-236 fibrinogen beta chain Homo sapiens 167-177 2070075-1 1991 The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP). Adenosine Diphosphate 216-237 fibrinogen beta chain Homo sapiens 25-35 2070075-1 1991 The relationship between fibrinogen binding to its receptor and platelet aggregation has been investigated by comparing 125I-fibrinogen binding and aggregation velocities of gel-filtered platelets in the presence of adenosine diphosphate (ADP). Adenosine Diphosphate 239-242 fibrinogen beta chain Homo sapiens 25-35 2070075-4 1991 Lowering ADP concentration increases Fmax, in agreement with the modulatory effect of ADP on fibrinogen binding to platelets. Adenosine Diphosphate 9-12 fibrinogen beta chain Homo sapiens 93-103 2070075-4 1991 Lowering ADP concentration increases Fmax, in agreement with the modulatory effect of ADP on fibrinogen binding to platelets. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 93-103 2070075-5 1991 Variations of fibrinogen in the range of physiopathologic plasma concentrations affect platelet aggregation induced by any ADP dose. Adenosine Diphosphate 123-126 fibrinogen beta chain Homo sapiens 14-24 1829631-8 1991 In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets. Adenosine Diphosphate 147-150 fibrinogen beta chain Homo sapiens 27-37 1902187-7 1991 In contrast, the extent of PT-catalyzed ADP-ribosylation of Gi alpha protein(s) decreases between Days 6.5 and 7.5--this decrease is global and not restricted to a particular germ layer of the Day 7.5 embryo--and then dramatically increases by Day 8.5 of gestation. Adenosine Diphosphate 40-43 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 60-68 1903793-2 1991 The post-translational poly ADP-ribosylation of proteins by the nuclear enzyme poly(ADP-ribose) polymerase (EC 2.4.2.30) involves a complex pattern of ADP-ribose polymers. Adenosine Diphosphate 28-31 poly(ADP-ribose) polymerase 1 Homo sapiens 79-106 2045172-3 1991 Indeed, the endothelium participates in the conversion of angiotensin I to angiotensin II; the enzymatic inactivation of several plasma constituents such as bradykinin, norepinephrine, serotonin, and ADP; and the synthesis and release of vasodilator substances such as prostacyclin and the recently discovered endothelium-derived relaxing factor (EDRF). Adenosine Diphosphate 200-203 angiotensinogen Homo sapiens 58-71 2045172-3 1991 Indeed, the endothelium participates in the conversion of angiotensin I to angiotensin II; the enzymatic inactivation of several plasma constituents such as bradykinin, norepinephrine, serotonin, and ADP; and the synthesis and release of vasodilator substances such as prostacyclin and the recently discovered endothelium-derived relaxing factor (EDRF). Adenosine Diphosphate 200-203 angiotensinogen Homo sapiens 75-89 2046403-6 1991 Aspirin inhibits 80% of the adenosine diphosphate-induced platelet vWF surface expression, and the platelet vWF surface expression that is not inhibited by aspirin can be almost totally inhibited by disruption of the platelet cytoskeleton. Adenosine Diphosphate 28-49 von Willebrand factor Homo sapiens 67-70 1828802-7 1991 For example, the ADP-heat-activated enzyme in presence of 1 mM Mg2+ binds ADP with a rate constant of 0.5 x 10(6) M-1 min-1 to give an enzyme with two ADP at noncatalytic sites with a Kd of about 0.1 microM. Adenosine Diphosphate 17-20 CD59 molecule (CD59 blood group) Homo sapiens 118-123 1828802-7 1991 For example, the ADP-heat-activated enzyme in presence of 1 mM Mg2+ binds ADP with a rate constant of 0.5 x 10(6) M-1 min-1 to give an enzyme with two ADP at noncatalytic sites with a Kd of about 0.1 microM. Adenosine Diphosphate 74-77 CD59 molecule (CD59 blood group) Homo sapiens 118-123 1828802-7 1991 For example, the ADP-heat-activated enzyme in presence of 1 mM Mg2+ binds ADP with a rate constant of 0.5 x 10(6) M-1 min-1 to give an enzyme with two ADP at noncatalytic sites with a Kd of about 0.1 microM. Adenosine Diphosphate 74-77 CD59 molecule (CD59 blood group) Homo sapiens 118-123 2042634-6 1991 The most powerful mitogen for BSC-1 cells is adenosine diphosphate (ADP). Adenosine Diphosphate 45-66 solute carrier family 12 member 1 Homo sapiens 30-35 2042634-6 1991 The most powerful mitogen for BSC-1 cells is adenosine diphosphate (ADP). Adenosine Diphosphate 68-71 solute carrier family 12 member 1 Homo sapiens 30-35 1902187-8 1991 In the Day 8.5 gestation embryo, the extent of PT-catalyzed ADP-ribosylation of Gi alpha proteins increases along the anterior-posterior axis, whereas the amount of immunoreactive alpha i subunit decreases along this axis. Adenosine Diphosphate 60-63 guanine nucleotide binding protein (G protein), alpha inhibiting 2 Mus musculus 80-88 1902217-7 1991 Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex. Adenosine Diphosphate 30-33 coagulation factor II, thrombin Homo sapiens 20-28 2021623-1 1991 We previously reported that the nucleotide complex of myosin subfragment 1, S1.epsilon ADP, exists in two states on the basis of the temperature dependence of the fluorescence decay of bound 1,N6-ethenoadenosine diphosphate (epsilon ADP) [Aguirre, R., Lin. Adenosine Diphosphate 233-236 proteasome 26S subunit, non-ATPase 1 Homo sapiens 76-78 2021623-3 1991 We have extended the previous study of the equilibrium between the two states, S1L.ADP in equilibrium S1H.ADP, by using a fluorescently labeled myosin S1 (S1-AF). Adenosine Diphosphate 83-86 proteasome 26S subunit, non-ATPase 1 Homo sapiens 79-81 2021623-3 1991 We have extended the previous study of the equilibrium between the two states, S1L.ADP in equilibrium S1H.ADP, by using a fluorescently labeled myosin S1 (S1-AF). Adenosine Diphosphate 106-109 proteasome 26S subunit, non-ATPase 1 Homo sapiens 79-81 2021623-4 1991 In S1 alkylated with IAF [5-(iodoacetamido)fluorescein], the decay of the label emission was biexponential both in the presence and absence of ADP and/or actin. Adenosine Diphosphate 143-146 proteasome 26S subunit, non-ATPase 1 Homo sapiens 3-5 2021623-1 1991 We previously reported that the nucleotide complex of myosin subfragment 1, S1.epsilon ADP, exists in two states on the basis of the temperature dependence of the fluorescence decay of bound 1,N6-ethenoadenosine diphosphate (epsilon ADP) [Aguirre, R., Lin. Adenosine Diphosphate 87-90 proteasome 26S subunit, non-ATPase 1 Homo sapiens 76-78 2053105-6 1991 In rat platelets, thrombin inhibited the PGE1-induced cAMP elevation but this effects seems to be entirely mediated by the released ADP. Adenosine Diphosphate 132-135 coagulation factor II Rattus norvegicus 18-26 1849890-6 1991 At 1 mM CTP, GTP, ITP, TTP, and AMP were without effect in either the presence or absence of insulin; in contrast, ADP was inhibitory in the presence of insulin. Adenosine Diphosphate 115-118 insulin Homo sapiens 153-160 2038215-4 1991 In the case of EF-2, the amounts of ADP-ribosylatable EF-2 neither declined during ageing nor differed between freely-fed and calorie-restricted animals. Adenosine Diphosphate 36-39 eukaryotic translation elongation factor 2 Rattus norvegicus 15-19 2038215-4 1991 In the case of EF-2, the amounts of ADP-ribosylatable EF-2 neither declined during ageing nor differed between freely-fed and calorie-restricted animals. Adenosine Diphosphate 36-39 eukaryotic translation elongation factor 2 Rattus norvegicus 54-58 2004328-2 1991 Previous studies found that hyperthermia alters the metabolism of adenosine diphosphate (ADP)-ribose polymers required for recovery from DNA damage and that poly(ADP-ribose) polymerase activity is very sensitive to cellular nicotinamide-adenine dinucleotide (NAD) levels. Adenosine Diphosphate 66-87 poly(ADP-ribose) polymerase 1 Homo sapiens 157-184 2004328-2 1991 Previous studies found that hyperthermia alters the metabolism of adenosine diphosphate (ADP)-ribose polymers required for recovery from DNA damage and that poly(ADP-ribose) polymerase activity is very sensitive to cellular nicotinamide-adenine dinucleotide (NAD) levels. Adenosine Diphosphate 89-92 poly(ADP-ribose) polymerase 1 Homo sapiens 157-184 1826078-6 1991 In all conditions tested, addition of Me2SO never promoted an increase of the apparent Km for ADP to a value higher than 25 microM. Adenosine Diphosphate 94-97 malic enzyme 2 Homo sapiens 38-41 1648497-1 1991 Treatment of cultured rat cardiomyocytes in serum-free medium for 48 h with recombinant human tumor necrosis factor alpha (TNF alpha) led to a concentration-dependent increase in the level of membrane-inhibitory guanine nucleotide-binding protein (Gi) alpha-subunits and in pertussis toxin-catalyzed [32P]ADP ribosylation of 40 kDa proteins. Adenosine Diphosphate 305-308 tumor necrosis factor Homo sapiens 94-121 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Adenosine Diphosphate 247-268 fibrinogen beta chain Homo sapiens 68-78 1899346-2 1991 The present study explored the direct association of membrane-bound fibrinogen with the Triton X-100 (Sigma Chemical Co, St Louis, MO) insoluble cytoskeleton of aspirin-treated, gel-filtered platelets, activated but not aggregated with 20 mumol/L adenosine diphosphate (ADP) or 150 mU/mL human thrombin (THR) when bound fibrinogen had become resistant to dissociation by EDTA. Adenosine Diphosphate 270-273 fibrinogen beta chain Homo sapiens 68-78 1899346-4 1991 After 60 minutes at 22 degrees C, the cytoskeleton of ADP-treated platelets contained 20% +/- 12% (mean +/- SD, n = 14) of membrane-bound 125I-fibrinogen, representing 10% to 50% of EDTA-resistant fibrinogen binding. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 143-153 1899346-4 1991 After 60 minutes at 22 degrees C, the cytoskeleton of ADP-treated platelets contained 20% +/- 12% (mean +/- SD, n = 14) of membrane-bound 125I-fibrinogen, representing 10% to 50% of EDTA-resistant fibrinogen binding. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 197-207 1846761-2 1991 HK (0.67 mumol/L) also completely inhibited thrombin-induced cleavage of aggregin (Mr = 100 Kd), a surface membrane protein that mediates adenosine diphosphate (ADP)-induced shape change, aggregation, and fibrinogen binding. Adenosine Diphosphate 138-159 coagulation factor II, thrombin Homo sapiens 44-52 1846761-2 1991 HK (0.67 mumol/L) also completely inhibited thrombin-induced cleavage of aggregin (Mr = 100 Kd), a surface membrane protein that mediates adenosine diphosphate (ADP)-induced shape change, aggregation, and fibrinogen binding. Adenosine Diphosphate 161-164 coagulation factor II, thrombin Homo sapiens 44-52 1995321-4 1991 Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Adenosine Diphosphate 128-131 integrin subunit beta 3 Homo sapiens 85-97 1648497-1 1991 Treatment of cultured rat cardiomyocytes in serum-free medium for 48 h with recombinant human tumor necrosis factor alpha (TNF alpha) led to a concentration-dependent increase in the level of membrane-inhibitory guanine nucleotide-binding protein (Gi) alpha-subunits and in pertussis toxin-catalyzed [32P]ADP ribosylation of 40 kDa proteins. Adenosine Diphosphate 305-308 tumor necrosis factor Homo sapiens 123-132 1846526-7 1991 We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 62-72 1665672-1 1991 The interaction of ADP-stimulated human platelets with human 125I-fibrinogen as well as with pig and bovine fibrinogens was analysed. Adenosine Diphosphate 19-22 fibrinogen beta chain Homo sapiens 66-76 2176614-3 1990 In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization. Adenosine Diphosphate 86-89 C-X-C motif chemokine ligand 8 Homo sapiens 64-67 26487523-5 1991 When 2.8 and 9 muM adenosine diphosphate were used as the aggregants, it became evident that higher ASA doses yielded still further grades of change both in aggregation and disaggregation. Adenosine Diphosphate 19-40 latexin Homo sapiens 15-18 1645175-1 1991 Addition of lithium ion to the inhibitory GTP-binding (Gi) protein resulted in a decrease of its ADP-ribosylation by islet-activating protein (pertussis toxin, IAP). Adenosine Diphosphate 97-100 alkaline phosphatase, intestinal Homo sapiens 160-163 1984896-5 1991 No relations were demonstrated with angina, but significant relations were shown between past myocardial infarctions and electrocardiographic evidence of ischemia and ADP-induced aggregation (both primary and secondary) and between electrocardiographic evidence of ischemia and thrombin-induced aggregation. Adenosine Diphosphate 167-170 coagulation factor II, thrombin Homo sapiens 278-286 1803325-2 1991 ADP is an original physiological agent in that, taking part as a substrate, product or allosteric effector in a large number of intracellular metabolic pathways, it also behaves as an agonist of blood platelet aggregation as do other agents including thrombin, platelet activating factor and collagen, but with probably different, yet unknown signal transduction pathways and also with unknown receptors. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 251-259 1803325-3 1991 We discuss, in this review, how ADP induces the characteristic functional responses of platelets, namely shape change, induction and exposure of the fibrinogen binding sites on the GP IIb-IIIa complex, fibrinogen binding to its receptor and platelet aggregation, and the intracellular biochemical events underlying these functions. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 149-159 1803325-3 1991 We discuss, in this review, how ADP induces the characteristic functional responses of platelets, namely shape change, induction and exposure of the fibrinogen binding sites on the GP IIb-IIIa complex, fibrinogen binding to its receptor and platelet aggregation, and the intracellular biochemical events underlying these functions. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 202-212 1776329-8 1991 10 micrograms/ml PRP of SIN 1 alone partially inhibited platelet aggregation induced by 1 microgram/ml collagen and 10(-6) M ADP respectively in uncovered aggregation cuvettes. Adenosine Diphosphate 125-128 prion protein Homo sapiens 17-20 1776329-8 1991 10 micrograms/ml PRP of SIN 1 alone partially inhibited platelet aggregation induced by 1 microgram/ml collagen and 10(-6) M ADP respectively in uncovered aggregation cuvettes. Adenosine Diphosphate 125-128 MAPK associated protein 1 Homo sapiens 24-29 2175608-6 1990 We found that: (i) ticlopidine inhibits aggregation by ADP but not the potentiation by Adr of ADP-induced aggregation; (ii) ADP, Adr or thrombin decreases cAMP levels raised by PGE1, an effect inhibited by ticlopidine only for ADP and not for Adr or thrombin; and (iii) Ca2+ influx and Ca2+ mobilization from internal stores were not affected. Adenosine Diphosphate 55-58 coagulation factor II, thrombin Homo sapiens 136-144 2176621-3 1990 In particular, the precursor of ADP/ATP carrier that is known not to interact with hsp60 on its assembly pathway requires functional mt-hsp70 for import, suggesting a general role of mt-hsp70 in membrane translocation of precursors. Adenosine Diphosphate 32-35 heat shock protein family A (Hsp70) member 9 Homo sapiens 133-141 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 61-64 fibrinogen beta chain Homo sapiens 13-23 2265706-5 1990 The reversible ADP-ribosylation of GRP78 could be part of a metabolic control mechanism in operation during nutritional stress. Adenosine Diphosphate 15-18 heat shock protein 5 Mus musculus 35-40 2174426-6 1990 Furthermore, C3-catalyzed ADP-ribosylation of rhoA* was dependent on guanine nucleotides in the presence of 1 mM Mg2+ or 1 mM EDTA (0.19 microM free Mg2+). Adenosine Diphosphate 26-29 ras homolog family member A Bos taurus 46-51 2174426-9 1990 This increase in ADP-ribosylation was specific for rhoA*; it was not observed with rhoB* and has not been reported for other C3 substrates. Adenosine Diphosphate 17-20 ras homolog family member A Bos taurus 51-55 2265706-0 1990 Reversible ADP-ribosylation of the 78 kDa glucose-regulated protein. Adenosine Diphosphate 11-14 heat shock protein 5 Mus musculus 35-67 2265706-2 1990 Here we show that the ADP-ribosylated and non-ADP-ribosylated forms of GRP78 are interconvertible during tryptophan starvation and refeeding. Adenosine Diphosphate 22-25 heat shock protein 5 Mus musculus 71-76 2265706-2 1990 Here we show that the ADP-ribosylated and non-ADP-ribosylated forms of GRP78 are interconvertible during tryptophan starvation and refeeding. Adenosine Diphosphate 46-49 heat shock protein 5 Mus musculus 71-76 2265706-3 1990 In addition, the ADP-ribosylation of GRP78 was shown to be reversible even during nutritional stress. Adenosine Diphosphate 17-20 heat shock protein 5 Mus musculus 37-42 2265706-4 1990 The overexpressed pool of non-ADP-ribosylated GRP78 synthesized during tunicamycin treatment was available for ADP-ribosylation during subsequent amino acid starvation, especially in the absence of tunicamycin. Adenosine Diphosphate 30-33 heat shock protein 5 Mus musculus 46-51 2265706-4 1990 The overexpressed pool of non-ADP-ribosylated GRP78 synthesized during tunicamycin treatment was available for ADP-ribosylation during subsequent amino acid starvation, especially in the absence of tunicamycin. Adenosine Diphosphate 111-114 heat shock protein 5 Mus musculus 46-51 2123802-3 1990 As reported for C3 substrates present in untreated ROS membranes, ADP-ribosylation of recombinant rho A proteins, both normal and Val-14 mutant, by C3 was inhibited when reconstituted with illuminated compared to dark-adapted ROS membranes pretreated with urea. Adenosine Diphosphate 66-69 ras homolog family member A Bos taurus 98-103 2123802-4 1990 GDP reduced the light-induced inhibition, while GTP[S] and light inhibited ADP-ribosylation of rho A proteins in a synergistic manner. Adenosine Diphosphate 75-78 ras homolog family member A Bos taurus 95-100 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 82-92 2261348-4 1990 Half-maximal fibrinogen binding occurred at about 0.4 microM ADP, and ADP-induced fibrinogen binding continued progressively during 20 min incubation with 10 microM ADP. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 82-92 2119831-8 1990 Cytochalasin D (CD) and monobromobimane (MB) enhanced agglutination and prevented the inhibitory action of ADP on bovine vWf-induced platelet agglutination. Adenosine Diphosphate 107-110 von Willebrand factor Bos taurus 121-124 2083485-6 1990 Adenosine-diphosphate (0.5-2 microM) or thrombin (0.1-0.4 NIH units ml-1) induced dose-dependent aggregation of platelets in citrate- or heparin-containing PRP; such aggregation was, however, not affected by ET-1 (1-100 microM) either. Adenosine Diphosphate 0-21 endothelin 1 Homo sapiens 208-212 2283997-7 1990 The mRNA of NAK1 was induced rapidly and transiently by growth-stimulating agents, such as adenosine diphosphate, in monkey kidney cells (BSC-1), by phytohemagglutinin in human lymphocytes, and by serum stimulation of arrested fibroblasts. Adenosine Diphosphate 91-112 nuclear receptor subfamily 4 group A member 1 Homo sapiens 12-16 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 182-192 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 277-287 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 182-192 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 fibrinogen beta chain Homo sapiens 277-287 2401846-6 1990 We conclude that inhibition of agglutination by ADP must involve the way in which vWf is bound, because it does not result from a decreased amount or from a difference in multimer size of bound vWf. Adenosine Diphosphate 48-51 von Willebrand factor Homo sapiens 82-85 2169312-8 1990 FMLP receptors in plasma membrane were shown to be coupled to the 40 kDa substrate for CT by ligand-modulation of ADP-ribosylation, while FMLP added to specific granules did not induce ribosylation of this substrate even though FMLP receptors were found in high density in this compartment. Adenosine Diphosphate 114-117 formyl peptide receptor 1 Homo sapiens 0-4 2401846-0 1990 Inhibition of von Willebrand factor-induced platelet agglutination by ADP does not result from reduced binding of total von Willebrand factor or its larger multimers. Adenosine Diphosphate 70-73 von Willebrand factor Homo sapiens 14-35 2401846-1 1990 Earlier experiments showed that platelet agglutination induced by von Willebrand factor (vWf) plus ristocetin was greatly diminished if adenosine diphosphate (ADP) was added first in the presence of ethylenediaminetetraacetic acid (to prevent aggregation). Adenosine Diphosphate 136-157 von Willebrand factor Homo sapiens 66-87 2255276-1 1990 It is postulated that ADP secreted by platelets is the physiological thromboplastin which initiates the conversion of prothrombin to thrombin and hence brings about the coagulation of the blood. Adenosine Diphosphate 22-25 coagulation factor II, thrombin Homo sapiens 121-129 2401846-1 1990 Earlier experiments showed that platelet agglutination induced by von Willebrand factor (vWf) plus ristocetin was greatly diminished if adenosine diphosphate (ADP) was added first in the presence of ethylenediaminetetraacetic acid (to prevent aggregation). Adenosine Diphosphate 136-157 von Willebrand factor Homo sapiens 89-92 2401846-1 1990 Earlier experiments showed that platelet agglutination induced by von Willebrand factor (vWf) plus ristocetin was greatly diminished if adenosine diphosphate (ADP) was added first in the presence of ethylenediaminetetraacetic acid (to prevent aggregation). Adenosine Diphosphate 159-162 von Willebrand factor Homo sapiens 66-87 2401846-1 1990 Earlier experiments showed that platelet agglutination induced by von Willebrand factor (vWf) plus ristocetin was greatly diminished if adenosine diphosphate (ADP) was added first in the presence of ethylenediaminetetraacetic acid (to prevent aggregation). Adenosine Diphosphate 159-162 von Willebrand factor Homo sapiens 89-92 2199438-5 1990 The binding of [32P]BzATP was competitively inhibited by ATP and ADP analogs (2-methylthioadenosine 5"-triphosphate greater than adenosine 5"-O-(2-thiodiphosphate) greater than BzATP greater than ATP greater than beta,gamma-methyleneadenosine 5"-triphosphate greater than 5"-adenylylimidodiphosphate) with pharmacological specificity consistent with that of a P2Y-purinergic receptor. Adenosine Diphosphate 65-68 P2Y purinoceptor 1 Meleagris gallopavo 360-383 2199438-8 1990 Photolabeling was inhibited in a concentration-dependent manner by ATP and ADP analogs with a potency order characteristic for a P2Y-purinergic receptor and was modulated by guanine nucleotides. Adenosine Diphosphate 75-78 P2Y purinoceptor 1 Meleagris gallopavo 129-152 2212309-10 1990 In both species, ADP growth as a function of stimulus level is approximately 1 with covaried stimuli; more gradual with the level of f2 (L 2) alone increasing and steeper when the level of f1 (L 1) alone is increased. Adenosine Diphosphate 17-20 L1 cell adhesion molecule Homo sapiens 180-196 2229026-1 1990 We showed previously that cytosolic adenylate kinase (AK1) purified from pig skeletal muscle catalyzes in vitro formation of thiamin triphosphate (TTP) from thiamin diphosphate (TDP) and ADP in addition to ATP formation from ADP [Shikata, H. et al. Adenosine Diphosphate 225-228 adenylate kinase 1 Sus scrofa 54-57 2229026-1 1990 We showed previously that cytosolic adenylate kinase (AK1) purified from pig skeletal muscle catalyzes in vitro formation of thiamin triphosphate (TTP) from thiamin diphosphate (TDP) and ADP in addition to ATP formation from ADP [Shikata, H. et al. Adenosine Diphosphate 187-190 adenylate kinase 1 Sus scrofa 54-57 2146766-4 1990 When washed platelets were supplemented with fibrinogen degradation products (FDPs) in concentrations simulating those in whole blood preincubated with t-PA, aggregation induced with either ADP or collagen was inhibited. Adenosine Diphosphate 190-193 plasminogen activator, tissue type Homo sapiens 152-156 1973186-4 1990 Further, we have causally related these events to the qualitative upregulation of CD11b/CD18, as exemplified by its inducible binding of factor X. Micromolar concentrations of ADP or ATP produce dose-dependent increase in monocyte cytosolic free [Ca2+]i through mobilization from intracellular stores coupled with a sustained, EGTA-sensitive, influx of Ca2+ from the external compartment. Adenosine Diphosphate 176-179 integrin subunit beta 2 Homo sapiens 88-92 1973186-6 1990 Ca2+ channel antagonists nifedipine or verapamil blocked the sustained phase of ADP-induced Ca2+ entry and inhibited 125I-factor X binding to CD11b/CD18 in a dose-dependent manner. Adenosine Diphosphate 80-83 integrin subunit beta 2 Homo sapiens 148-152 2141549-7 1990 Platelet stimulation with thrombin or ADP in the presence of fibrinogen also did not alter the number of Fc gamma binding sites or the affinity of binding. Adenosine Diphosphate 38-41 fibrinogen beta chain Homo sapiens 61-71 1973186-8 1990 In monocytes, depolarizing conditions by high external [K+] or by the Na+ ionophore gramicidin D mimicked the stimulatory effect of ADP, inducing increased cytosolic free [Ca2+]i and 125I-factor X binding to CD11b/CD18. Adenosine Diphosphate 132-135 integrin subunit beta 2 Homo sapiens 214-218 2375765-10 1990 Fibrinogen binding was dramatically inhibited in rat and in man when platelets were stimulated with ADP and low concentrations of thrombin. Adenosine Diphosphate 100-103 fibrinogen beta chain Homo sapiens 0-10 2237813-0 1990 Fibrinogen-containing membrane-associated structures arising at the surfaces of ADP-stimulated blood platelets. Adenosine Diphosphate 80-83 fibrinogen beta chain Homo sapiens 0-10 2237813-1 1990 Ultrastructural studies of ADP-stimulated gel-filtered human platelets incubated with different concentrations of fibrinogen reveal unusual extracellular structures composed at least partly of the aggregated fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 114-124 2237813-1 1990 Ultrastructural studies of ADP-stimulated gel-filtered human platelets incubated with different concentrations of fibrinogen reveal unusual extracellular structures composed at least partly of the aggregated fibrinogen. Adenosine Diphosphate 27-30 fibrinogen beta chain Homo sapiens 208-218 2207277-1 1990 The amidase activity of human alpha-thrombin has been studied in the presence of the adenosine nucleotides AMP, ADP and ATP. Adenosine Diphosphate 112-115 coagulation factor II, thrombin Homo sapiens 36-44 2402082-7 1990 ADP-induced aggregation was suppressed in 3 out of 4 cases with thrombin production although no close correlation was observed between maximal aggregation rate and the concentration of thrombin. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 64-72 2159891-3 1990 On the other hand, ADP and ATP enhanced the rates of reduction of both adrenodoxin and cytochrome c through adrenodoxin by the electron transport system. Adenosine Diphosphate 19-22 cytochrome c, somatic Homo sapiens 87-99 2333284-1 1990 alpha-Thrombin and phorbol 12,13-dibutyrate stimulated the mono(ADP-ribosyl)ation of a 42-kDa cytosolic protein of human platelets. Adenosine Diphosphate 64-67 coagulation factor II, thrombin Homo sapiens 6-14 2159285-4 1990 In the presence of ethanol, thrombin and other agonists (platelet-activating factor, adrenaline and ADP, as well as fetal-calf serum) stimulated the appearance of phosphatidylethanol, an indicator of phospholipase D activity. Adenosine Diphosphate 100-103 coagulation factor II, thrombin Homo sapiens 28-36 2407587-1 1990 ADP is known to induce platelet shape change, aggregation, and exposure of fibrinogen binding sites as well as inhibit stimulated adenylate cyclase. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 75-85 2108672-1 1990 Adenosine Diphosphoribosyl Transferase is a eucaryotic nuclear protein that catalyses the transfer of ADP-ribose moiety of NAD+ to itself and other cellular proteins. Adenosine Diphosphate 102-105 poly(ADP-ribose) polymerase 1 Homo sapiens 0-38 2137716-0 1990 Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates. Adenosine Diphosphate 9-30 coagulation factor II, thrombin Homo sapiens 42-50 2321555-8 1990 The shift of the LDH isoenzyme pattern and the decrease of the ADP/ATP concentration can be taken as an indication for an improvement of the myocardial energy balance in chronic heart failure with angiotensin-converting enzyme inhibitor therapy. Adenosine Diphosphate 63-66 angiotensin I converting enzyme Homo sapiens 197-226 2346725-8 1990 Calpain proteolysis of vWF changed the binding characteristics of the vWF so that it had greatly increased binding to both ADP and calpain activated platelets. Adenosine Diphosphate 123-126 von Willebrand factor Homo sapiens 23-26 2346725-8 1990 Calpain proteolysis of vWF changed the binding characteristics of the vWF so that it had greatly increased binding to both ADP and calpain activated platelets. Adenosine Diphosphate 123-126 von Willebrand factor Homo sapiens 70-73 2364954-8 1990 This shift in the LDH isoenzyme pattern and decrease in the ADP/ATP-concentration can be interpreted as an indication for an improvement of myocardial energy balance in chronic heart failure under ACE-inhibitor therapy. Adenosine Diphosphate 60-63 angiotensin I converting enzyme Homo sapiens 197-200 2303480-3 1990 Prior exposure of saponin-treated platelets to anti-p24/CD9 inhibited the [32P] ADP-ribosylation of the alpha 41 protein by pertussis toxin. Adenosine Diphosphate 80-83 transmembrane p24 trafficking protein 2 Homo sapiens 52-55 2407587-4 1990 Concomitant with incorporation of FSBA, ADP-induced shape change, aggregation, and fibrinogen binding is inhibited. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 83-93 2407587-11 1990 Thrombin at concentrations greater than 2 nM (0.2 units/ml) stimulates platelet aggregation independent of ADP, but by raising cytoplasmic Ca2+ it activates platelet calpain, which in turn cleaves aggregin. Adenosine Diphosphate 107-110 coagulation factor II, thrombin Homo sapiens 0-8 2105104-4 1990 The FMLP response was blocked by pertussis toxin (100 ng/ml for 4 h) which catalysed [32P]ADP ribosylation of a 40 kDa "Gi-like" G-protein alpha subunit in these cells. Adenosine Diphosphate 90-93 formyl peptide receptor 1 Homo sapiens 4-8 2154674-1 1990 Agglutination of human platelets by bovine von Willebrand factor (vWF) or by human vWF in the presence of ristocetin is inhibited by ADP and by several other platelet agonists but not by epinephrine. Adenosine Diphosphate 133-136 von Willebrand factor Bos taurus 43-64 2154674-1 1990 Agglutination of human platelets by bovine von Willebrand factor (vWF) or by human vWF in the presence of ristocetin is inhibited by ADP and by several other platelet agonists but not by epinephrine. Adenosine Diphosphate 133-136 von Willebrand factor Bos taurus 66-69 2154674-1 1990 Agglutination of human platelets by bovine von Willebrand factor (vWF) or by human vWF in the presence of ristocetin is inhibited by ADP and by several other platelet agonists but not by epinephrine. Adenosine Diphosphate 133-136 von Willebrand factor Homo sapiens 83-86 2154674-5 1990 ADP caused a small decrease in the number and affinity of binding sites for vWF on platelets, too small to explain the inhibition of agglutination. Adenosine Diphosphate 0-3 von Willebrand factor Homo sapiens 76-79 2202919-1 1990 The influence of uremic serum on 125I-fibrinogen binding by normal blood platelets after induction with adenosine diphosphate was evaluated. Adenosine Diphosphate 104-125 fibrinogen beta chain Homo sapiens 38-48 2153688-3 1990 This inhibitory effect was specific for TGF beta 1-stimulated proto-oncogene expression and associated with the ADP-ribosylation of a 41-kDa substrate. Adenosine Diphosphate 112-115 transforming growth factor beta 1 Homo sapiens 40-50 2109080-2 1990 Therefore, Gs alpha was radiolabeled by cholera toxin-catalzyed (32P)ADP-ribosylation with (32P)NAD as substrate. Adenosine Diphosphate 69-72 GNAS complex locus Homo sapiens 11-19 2109080-8 1990 The amounts of Gs alpha as measured by cholera toxin-dependent (32P)-ADP-ribosylation in the presence of ARR were similar in failing and nonfailing human hearts. Adenosine Diphosphate 69-72 GNAS complex locus Homo sapiens 15-23 2153488-2 1990 The release of arginine vasopressin from human platelets was investigated in platelet-rich plasma after irreversible aggregation induced by adenosine 5"-pyrophosphate, collagen, sodium arachidonate, thrombin and adrenaline in vitro. Adenosine Diphosphate 140-166 arginine vasopressin Homo sapiens 24-35 2153488-6 1990 An arginine vasopressin level of 18 X 10(12) mol/l, which can be achieved physiologically, increased the sensitivity of platelets to adenosine 5"-pyrophosphate and collagen in vitro; the same concentration of arginine vasopressin caused a potentiation of the effect of catecholamines on the response of platelets to sodium arachidonate. Adenosine Diphosphate 133-159 arginine vasopressin Homo sapiens 12-23 2110108-2 1990 The results suggest that NADPH- and ADP--Fe3(+)-dependent lipid peroxidation involves both NADPH--cytochrome P450 reductase and cytochrome P450. Adenosine Diphosphate 26-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 98-113 2105325-10 1990 Preincubation of HUVEC microsomal membranes with alpha-thrombin diminished pertussis toxin-catalyzed ADP ribosylation in a time-dependent manner. Adenosine Diphosphate 101-104 coagulation factor II, thrombin Homo sapiens 55-63 33763084-0 2021 ADP-Ribosylation Regulates the Signaling Function of IFN-gamma. Adenosine Diphosphate 0-3 interferon gamma Mus musculus 53-62 2140894-2 1990 The involvement of dansylated ATP, ADP and AMP as substrate analogues in energy metabolism is demonstrated in the ATPase, hexokinase, pyruvate kinase and adenylate kinase reactions. Adenosine Diphosphate 35-38 hexokinase 1 Homo sapiens 122-132 33940558-3 2021 In response to DNA strand breaks, PARP1 covalently attaches ADP-ribose moieties to arginine, glutamate, aspartate, cysteine, lysine, and serine acceptor sites on both itself and other proteins. Adenosine Diphosphate 60-63 poly(ADP-ribose) polymerase 1 Homo sapiens 34-39 33940558-5 2021 PARP1 binding to these sites enhances ADP-ribosylation via allosteric communication between the distant DNA binding and catalytic domains. Adenosine Diphosphate 38-41 poly(ADP-ribose) polymerase 1 Homo sapiens 0-5 33940558-7 2021 Clinical PARP1 inhibitors bind the catalytic pocket, where they directly interfere with ADP-ribosylation. Adenosine Diphosphate 88-91 poly(ADP-ribose) polymerase 1 Homo sapiens 9-14 33763084-7 2021 Indeed, binding of IFN-gamma to IFNR1 blocks ADP-ribosylation of IFN-gamma. Adenosine Diphosphate 45-48 interferon gamma Mus musculus 19-28 33763084-7 2021 Indeed, binding of IFN-gamma to IFNR1 blocks ADP-ribosylation of IFN-gamma. Adenosine Diphosphate 45-48 interferon gamma Mus musculus 65-74 33763084-9 2021 Our results show that ADP-ribosylation inhibits the signaling functions of IFN-gamma and point to a new regulatory mechanism for controlling signaling by IFN-gamma. Adenosine Diphosphate 22-25 interferon gamma Mus musculus 75-84 33763084-9 2021 Our results show that ADP-ribosylation inhibits the signaling functions of IFN-gamma and point to a new regulatory mechanism for controlling signaling by IFN-gamma. Adenosine Diphosphate 22-25 interferon gamma Mus musculus 154-163 17349882-7 2007 RESULTS: Platelet activation markers (P-selectin) after stimulation (adenosine diphosphate) were reduced by 40 mg/day of atorvastatin (-5.2 +/- 1.6 arbitrary units) but not by ezetimibe plus low-dose atorvastatin (2.1 +/- 1.8 arbitrary units; p < 0.005) despite a similar reduction of LDL-C (atorvastatin -1.01 +/- 0.18 mmol/l vs. ezetimibe plus atorvastatin -1.36 +/- 0.22 mmol/l, p = NS). Adenosine Diphosphate 69-90 component of oligomeric golgi complex 2 Homo sapiens 288-293 33589610-2 2021 Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Adenosine Diphosphate 32-35 histone PARylation factor 1 Homo sapiens 92-96 33589610-7 2021 Our data show that through salt-bridging to Glu284/Asp286, Arg239 positions Glu284 to catalyze serine ADP-ribosylation, maintains the local conformation of HPF1 to limit PARP1 automodification, and facilitates HPF1/PARP1 binding by neutralizing the negative charge of Glu284. Adenosine Diphosphate 102-105 histone PARylation factor 1 Homo sapiens 156-160 33589610-7 2021 Our data show that through salt-bridging to Glu284/Asp286, Arg239 positions Glu284 to catalyze serine ADP-ribosylation, maintains the local conformation of HPF1 to limit PARP1 automodification, and facilitates HPF1/PARP1 binding by neutralizing the negative charge of Glu284. Adenosine Diphosphate 102-105 poly(ADP-ribose) polymerase 1 Homo sapiens 170-175 33589610-7 2021 Our data show that through salt-bridging to Glu284/Asp286, Arg239 positions Glu284 to catalyze serine ADP-ribosylation, maintains the local conformation of HPF1 to limit PARP1 automodification, and facilitates HPF1/PARP1 binding by neutralizing the negative charge of Glu284. Adenosine Diphosphate 102-105 histone PARylation factor 1 Homo sapiens 210-214 33589610-7 2021 Our data show that through salt-bridging to Glu284/Asp286, Arg239 positions Glu284 to catalyze serine ADP-ribosylation, maintains the local conformation of HPF1 to limit PARP1 automodification, and facilitates HPF1/PARP1 binding by neutralizing the negative charge of Glu284. Adenosine Diphosphate 102-105 poly(ADP-ribose) polymerase 1 Homo sapiens 215-220 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 114-135 phospholipase A2, group V Mus musculus 56-60 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 137-140 phospholipase A2, group V Mus musculus 56-60 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 168-171 phospholipase A2, group V Mus musculus 56-60 25313821-6 2014 These results suggest that iPLA2gamma is an additional, long-sought-after PLA2 that hydrolyzes platelet membranes and facilitates platelet aggregation in response to ADP. Adenosine Diphosphate 166-169 phospholipase A2, group V Mus musculus 28-32 34592041-5 2022 RESULTS: PDIA1 was less abundant compared to PDIA3 in resting platelets and platelets stimulated with TRAP-14, collagen or ADP. Adenosine Diphosphate 123-126 protein disulfide isomerase family A member 3 Homo sapiens 45-50 9795233-4 1998 The thrombin-induced (0.1 U/ml) increase in production of [32P]PA, "overshoots" in [32P]PIP and [32P]PIP2 ([32P]phosphatidylinositol 4,5-bisphosphate), and the increase in [32P]PI and secretion of ADP+ATP were abolished by forskolin (10-7 M). Adenosine Diphosphate 197-200 coagulation factor II, thrombin Homo sapiens 4-12 21043848-6 1993 The marked platelet activation caused by the high ADP concentrations used with conventional Born aggregometry may have masked a modest LDL-induced platelet activation as a slight increase in spontaneous platelet aggregation was observed in PRP at the intermediate LDL-concentration. Adenosine Diphosphate 50-53 complement component 4 binding protein alpha Homo sapiens 240-243 34340015-1 2021 PARP1 and PARP2 govern the DNA-damage response by catalysing the reversible post-translational modification ADP-ribosylation. Adenosine Diphosphate 108-111 poly(ADP-ribose) polymerase 1 Homo sapiens 0-5 34825567-2 2021 Physiological opening and closing of KATPs present in pancreatic beta-cells, in response to changes in the ATP/ADP concentration ratio, are correlated with insulin release into the bloodstream. Adenosine Diphosphate 111-114 insulin Homo sapiens 156-163 34314506-4 2021 Our data revealed a significant increase in the ATP/ADP ratios of both mutants, indicating clear alterations in energy metabolism, and a reduced respiratory rate in atucp2. Adenosine Diphosphate 52-55 uncoupling protein 2 Arabidopsis thaliana 165-171 34961895-9 2022 Our study identifies human CD73 as target for ARTC1-mediated mono-ADP-ribosylation, which can profoundly modulate its adenosine-generating activity. Adenosine Diphosphate 66-69 ADP-ribosyltransferase 1 Homo sapiens 46-51 34941000-7 2022 Unlike the canonical ATP to ADP hydrolysis observed for Hsp70s, this ATP hydrolysis to AMP depends on the substrate-binding domain of BiP and is inhibited by the binding of a peptide substrate. Adenosine Diphosphate 28-31 heat shock protein family A (Hsp70) member 5 Homo sapiens 134-137 34688677-5 2021 In vivo experiments suggested that ADP significantly inhibited the tumor growth of mice, increased the activities of spleen lymphocytes and natural killer (NK) cells, improved the cytokine level (IL-2 and TNF-alpha) and the proportions of lymphocyte subsets in the peripheral blood. Adenosine Diphosphate 35-38 tumor necrosis factor Mus musculus 205-214 34860335-8 2021 In the candidate gene analysis, rs7830 (NOS3) was associated with both ADP aggregation rate and 18- and 30-month ISR, and rs 62,275,847 (AGTR1) was associated with both ADP aggregation rate and 30-month ISR. Adenosine Diphosphate 71-74 nitric oxide synthase 3 Homo sapiens 40-44 34860335-9 2021 In the pathway, gene-set analysis, the linkage rs471683 and rs7785386 of GNAI1 GNAT3 were associated with PRU and ADP aggregation rate, 18-month and 30-month ISR, and repeat revascularization within 30 months. Adenosine Diphosphate 114-117 G protein subunit alpha transducin 3 Homo sapiens 79-84 34860335-10 2021 Rs1715389 of GNAI1 GNAT3 was associated with both PRU and ADP aggregation rate, 18-month and 30-month ISR, and repeat revascularization within 30 months. Adenosine Diphosphate 58-61 G protein subunit alpha transducin 3 Homo sapiens 19-24 34860335-11 2021 Rs7313458 of ITPR2 was associated with PRU and ADP aggregation rate, 18-month and 30-month ISR, and repeat revascularization within 18 months. Adenosine Diphosphate 47-50 inositol 1,4,5-trisphosphate receptor type 2 Homo sapiens 13-18 34340015-1 2021 PARP1 and PARP2 govern the DNA-damage response by catalysing the reversible post-translational modification ADP-ribosylation. Adenosine Diphosphate 108-111 poly(ADP-ribose) polymerase 2 Homo sapiens 10-15 34880500-4 2021 Here we show that hormonal FABP4 forms a functional hormone complex with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK) to regulate extracellular ATP and ADP levels. Adenosine Diphosphate 171-174 adenosine kinase Homo sapiens 73-89 34724256-6 2021 Ectopic NDUFA4L2 expression resulted in reduced mitochondrial respiration and reactive oxygen species followed by lowered AMP, ADP, ATP, and NAD+ levels without affecting the overall protein content of the mitochondrial electron transport chain. Adenosine Diphosphate 127-130 Ndufa4, mitochondrial complex associated like 2 Mus musculus 8-16 34561299-6 2021 Interestingly, of these ten, only four - R130H, R132C, W211R, and N286I - reduced both canonical CKM activities: ADP phosphorylation and ATP dephosphorylation. Adenosine Diphosphate 113-116 creatine kinase, M-type Homo sapiens 97-100 34880500-4 2021 Here we show that hormonal FABP4 forms a functional hormone complex with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK) to regulate extracellular ATP and ADP levels. Adenosine Diphosphate 171-174 adenosine kinase Homo sapiens 91-94 34837556-7 2022 Furthermore, in the renal medulla, BAIBA increased the levels of ATP, ADP, AMP, and ADP/ATP ratio, thus further activating AMPK phosphorylation. Adenosine Diphosphate 70-73 alanine--glyoxylate aminotransferase 2 Homo sapiens 35-40 34837556-7 2022 Furthermore, in the renal medulla, BAIBA increased the levels of ATP, ADP, AMP, and ADP/ATP ratio, thus further activating AMPK phosphorylation. Adenosine Diphosphate 84-87 alanine--glyoxylate aminotransferase 2 Homo sapiens 35-40 34508355-0 2021 TARG1 protects against toxic DNA ADP-ribosylation. Adenosine Diphosphate 33-36 O-acyl-ADP-ribose deacylase 1 Homo sapiens 0-5 34869334-2 2021 In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites. Adenosine Diphosphate 74-77 poly(ADP-ribose) polymerase 1 Homo sapiens 27-38 34750509-6 2021 These observations suggest that PARP1/HPF1-mediated serine ADP-ribosylation, when driven by SIRT inhibition, can inadvertently inhibit the growth of BRCA-gene mutant cells. Adenosine Diphosphate 59-62 poly(ADP-ribose) polymerase 1 Homo sapiens 32-37 34750509-6 2021 These observations suggest that PARP1/HPF1-mediated serine ADP-ribosylation, when driven by SIRT inhibition, can inadvertently inhibit the growth of BRCA-gene mutant cells. Adenosine Diphosphate 59-62 histone PARylation factor 1 Homo sapiens 38-42 34647721-4 2021 We observe divergent ADP-ribosylation dynamics for the catalytic domains of PARPs 14 and 15, with PARP15 modifying more sites on itself (+3-4 ADP-ribose) than the closely related PARP14 protein (+1-2 ADP-ribose)-despite similar numbers of potential modification sites. Adenosine Diphosphate 200-203 poly(ADP-ribose) polymerase 1 Homo sapiens 76-81 34647721-4 2021 We observe divergent ADP-ribosylation dynamics for the catalytic domains of PARPs 14 and 15, with PARP15 modifying more sites on itself (+3-4 ADP-ribose) than the closely related PARP14 protein (+1-2 ADP-ribose)-despite similar numbers of potential modification sites. Adenosine Diphosphate 200-203 poly(ADP-ribose) polymerase family member 15 Homo sapiens 98-104 34727004-6 2021 Furthermore, the IC50 values of ATP, ADP, NAD+, and NADP+ were approximately 15 muM.In our previous study, ATP was the strongest inhibitor of UGT activity in RLM. Adenosine Diphosphate 37-40 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 142-145 34727004-8 2021 Furthermore, AMP antagonised the inhibitory effects of ATP and ADP.These results suggest that ATP, ADP, NAD+, and NADP+ are common endogenous inhibitors of UGT beyond species. Adenosine Diphosphate 63-66 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 156-159 34727004-8 2021 Furthermore, AMP antagonised the inhibitory effects of ATP and ADP.These results suggest that ATP, ADP, NAD+, and NADP+ are common endogenous inhibitors of UGT beyond species. Adenosine Diphosphate 99-102 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 156-159 34682866-6 2021 Furthermore, ADP- and AYPGKF-induced Akt and ERK phosphorylation were significantly increased in arrestin3-deficient platelets. Adenosine Diphosphate 13-16 thymoma viral proto-oncogene 1 Mus musculus 37-40 34682866-6 2021 Furthermore, ADP- and AYPGKF-induced Akt and ERK phosphorylation were significantly increased in arrestin3-deficient platelets. Adenosine Diphosphate 13-16 mitogen-activated protein kinase 1 Mus musculus 45-48 34508355-5 2021 Here, we show that TARG1, like DarG, can reverse thymidine-linked DNA ADP-ribosylation. Adenosine Diphosphate 70-73 O-acyl-ADP-ribose deacylase 1 Homo sapiens 19-24 34508355-6 2021 We find that TARG1-deficient human cells are extremely sensitive to DNA ADP-ribosylation. Adenosine Diphosphate 72-75 O-acyl-ADP-ribose deacylase 1 Homo sapiens 13-18 34169408-12 2021 IL-1B had the diagnostic power of 0.72 in distinguishing between ADP cases and controls. Adenosine Diphosphate 65-68 interleukin 1 beta Homo sapiens 0-5 34623563-3 2022 Hexokinase (HK) is a key enzyme on glucose metabolism and is coupled to the brain mitochondrial redox modulation by recycling ADP for oxidative phosphorylation (OXPHOS). Adenosine Diphosphate 126-129 hexokinase 1 Homo sapiens 0-10 34623563-3 2022 Hexokinase (HK) is a key enzyme on glucose metabolism and is coupled to the brain mitochondrial redox modulation by recycling ADP for oxidative phosphorylation (OXPHOS). Adenosine Diphosphate 126-129 hexokinase 1 Homo sapiens 12-14 34675608-1 2021 Introduction: ENPP1 and ENTPD1 are two main enzymes involved in ATP-AMP-ADP-adenosine axis, which is associated with lipid metabolism, diabetes mellitus (DM) and renal fibrosis. Adenosine Diphosphate 72-75 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 14-19 34348571-3 2022 Here we show that Kv1.3-deficient platelets display enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin alphaIIb. Adenosine Diphosphate 61-64 potassium voltage-gated channel, shaker-related subfamily, member 3 Mus musculus 18-23 34516596-6 2021 Specifically, we found that glucose oxidase and hexokinase fragment in the presence of D-glucose but not L-glucose, while hexokinase aggregates in the presence of Mg2+ ion and either ATP or ADP at low pH. Adenosine Diphosphate 190-193 hexokinase 1 Homo sapiens 48-58 34516596-6 2021 Specifically, we found that glucose oxidase and hexokinase fragment in the presence of D-glucose but not L-glucose, while hexokinase aggregates in the presence of Mg2+ ion and either ATP or ADP at low pH. Adenosine Diphosphate 190-193 hexokinase 1 Homo sapiens 122-132 34480694-4 2022 We show that extracellular ADP (eADP) and its receptors are obviously increased in synovial tissues of RA patients as well as collagen-induced arthritis (CIA) mice, and eADP enhances neutrophil infiltration into joints through macrophages producing the chemokine CXCL2, aggravating disease development. Adenosine Diphosphate 27-30 chemokine (C-X-C motif) ligand 2 Mus musculus 263-268 34264286-2 2021 ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L). Adenosine Diphosphate 90-93 androgen receptor Homo sapiens 16-18 34366182-5 2022 In this review, we discuss the design principles behind these two strategies and how target identification has provided novel insight into the cellular function of individual PARPs and PARP-mediated ADP-ribosylation. Adenosine Diphosphate 199-202 poly(ADP-ribose) polymerase 1 Homo sapiens 185-189 34581777-3 2022 Here, we report GWAS of pathway specific functional responses to agonism by ADP, a glycoprotein VI-specific collagen mimetic and thrombin receptor-agonist peptides, each specific to one of the G protein-coupled receptors PAR-1 and PAR-4, in subsets of 1,562 individuals. Adenosine Diphosphate 76-79 coagulation factor II thrombin receptor Homo sapiens 221-226 34076906-11 2021 Taken together, the results suggested that P2X7 receptors can be sensitized to ATP by NAD+ /ARTC2-catalyzed ADP-ribosylation, which allows astrocytes to drive P2X7 receptor-mediated ischemic tolerance even though PC only slightly increases the amount of eATP. Adenosine Diphosphate 108-111 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 159-172 34465804-6 2021 Mediated by platelets, ADP results in activation of the integrin receptor Mac-1 on blood monocytes, as detected by the conformation-specific single-chain antibody MAN-1. Adenosine Diphosphate 23-26 integrin subunit beta 2 Homo sapiens 74-79 34465804-6 2021 Mediated by platelets, ADP results in activation of the integrin receptor Mac-1 on blood monocytes, as detected by the conformation-specific single-chain antibody MAN-1. Adenosine Diphosphate 23-26 LEM domain containing 3 Homo sapiens 163-168 34129667-0 2021 Insulin rapidly increases skeletal muscle mitochondrial ADP sensitivity in the absence of a high lipid environment. Adenosine Diphosphate 56-59 insulin Homo sapiens 0-7 34129667-4 2021 increased submaximal (100-1000 muM ADP) mitochondrial respiration ~2-fold without altering maximal (>1000 muM ADP) respiration, suggesting insulin rapidly improves mitochondrial bioenergetics. Adenosine Diphosphate 35-38 insulin Homo sapiens 139-146 34129667-5 2021 The consumption of HFD impaired submaximal ADP-supported respiration ~50%, however, despite the induction of insulin resistance, the ability of acute insulin to stimulate ADP sensitivity and increase submaximal respiration persisted. Adenosine Diphosphate 171-174 insulin Homo sapiens 150-157 34129667-7 2021 Altogether, these data show that while insulin rapidly stimulates mitochondrial bioenergetics through an improvement in ADP sensitivity, this phenomenon is possibly lost following HFD due to the presence of intracellular lipids. Adenosine Diphosphate 120-123 insulin Homo sapiens 39-46 35503763-0 2022 AICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle. Adenosine Diphosphate 133-136 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 68-96 35549263-3 2022 It greatly suppressed ADP-induced platelet aggregation, activation, and Akt phosphorylation in vitro and ex vivo after oral administration to mice. Adenosine Diphosphate 22-25 thymoma viral proto-oncogene 1 Mus musculus 72-75 35514261-7 2022 MRS2179 reduced ADP-induced Akt phosphorylation but did not abolish it. Adenosine Diphosphate 16-19 AKT serine/threonine kinase 1 Homo sapiens 28-31 34291079-10 2021 Additionally, ADP activated the NF-kappaB signaling pathway to promote CXCL10 release. Adenosine Diphosphate 14-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 32-41 34235204-7 2021 We discovered that while thrombin upregulated both surface and cellular HMGB1 expression, LPS-mediated activation in the presence of ADP priming led to upregulation of surface HMGB1 expression. Adenosine Diphosphate 133-136 high mobility group box 1 Canis lupus familiaris 176-181 35523115-12 2022 Furthermore, the protein expression of BDNF, p-TrkB, mu-calpain, PSD95, GluN2A, GluA1, p-AKT, p-mTOR, and ARC was decreased, while that of PTEN and GluN2B was increased in the hippocampus of mice subjected to SPS compared with that in control animals; however, these changes in protein expression were reversed following ADP treatment. Adenosine Diphosphate 321-324 phosphatase and tensin homolog Mus musculus 139-143 35625598-0 2022 ADP-Induced Conformational Transition of Human Adenylate Kinase 1 Is Triggered by Suppressing Internal Motion of alpha3alpha4 and alpha7alpha8 Fragments on the ps-ns Timescale. Adenosine Diphosphate 0-3 adenylate kinase 1 Homo sapiens 47-65 35625598-2 2022 In the presence of Mg2+ ions, hAK1 in vivo can catalyze two ADP molecules into one ATP and one AMP molecule, activating the downstream AMP signaling. Adenosine Diphosphate 60-63 adenylate kinase 1 Homo sapiens 30-34 35625598-3 2022 The ADP-binding also initiates AK1 transition from an open conformation to a closed conformation. Adenosine Diphosphate 4-7 adenylate kinase 1 Homo sapiens 31-34 35625598-5 2022 Herein, we determined the solution structure of apo-hAK1 and its key residues for catalyzing ADP, and characterized backbone dynamics characteristics of apo-hAK1 and hAK1-Mg2+-ADP complex (holo-hAK1) using NMR relaxation experiments. Adenosine Diphosphate 93-96 adenylate kinase 1 Homo sapiens 52-56 35625598-5 2022 Herein, we determined the solution structure of apo-hAK1 and its key residues for catalyzing ADP, and characterized backbone dynamics characteristics of apo-hAK1 and hAK1-Mg2+-ADP complex (holo-hAK1) using NMR relaxation experiments. Adenosine Diphosphate 93-96 adenylate kinase 1 Homo sapiens 157-161 35625598-5 2022 Herein, we determined the solution structure of apo-hAK1 and its key residues for catalyzing ADP, and characterized backbone dynamics characteristics of apo-hAK1 and hAK1-Mg2+-ADP complex (holo-hAK1) using NMR relaxation experiments. Adenosine Diphosphate 93-96 adenylate kinase 1 Homo sapiens 166-170 35625598-5 2022 Herein, we determined the solution structure of apo-hAK1 and its key residues for catalyzing ADP, and characterized backbone dynamics characteristics of apo-hAK1 and hAK1-Mg2+-ADP complex (holo-hAK1) using NMR relaxation experiments. Adenosine Diphosphate 176-179 adenylate kinase 1 Homo sapiens 52-56 35625598-5 2022 Herein, we determined the solution structure of apo-hAK1 and its key residues for catalyzing ADP, and characterized backbone dynamics characteristics of apo-hAK1 and hAK1-Mg2+-ADP complex (holo-hAK1) using NMR relaxation experiments. Adenosine Diphosphate 176-179 adenylate kinase 1 Homo sapiens 166-170 35625598-6 2022 We found that ADP was primarily bound to a cavity surrounded by the LID, NMP, and CORE domains of hAK1, and identified several critical residues for hAK1 catalyzing ADP including G16, G18, G20, G22, T39, G40, R44, V67, D93, G94, D140, and D141. Adenosine Diphosphate 14-17 adenylate kinase 1 Homo sapiens 98-102 35625598-6 2022 We found that ADP was primarily bound to a cavity surrounded by the LID, NMP, and CORE domains of hAK1, and identified several critical residues for hAK1 catalyzing ADP including G16, G18, G20, G22, T39, G40, R44, V67, D93, G94, D140, and D141. Adenosine Diphosphate 14-17 adenylate kinase 1 Homo sapiens 149-153 35625598-6 2022 We found that ADP was primarily bound to a cavity surrounded by the LID, NMP, and CORE domains of hAK1, and identified several critical residues for hAK1 catalyzing ADP including G16, G18, G20, G22, T39, G40, R44, V67, D93, G94, D140, and D141. Adenosine Diphosphate 165-168 adenylate kinase 1 Homo sapiens 98-102 35625598-6 2022 We found that ADP was primarily bound to a cavity surrounded by the LID, NMP, and CORE domains of hAK1, and identified several critical residues for hAK1 catalyzing ADP including G16, G18, G20, G22, T39, G40, R44, V67, D93, G94, D140, and D141. Adenosine Diphosphate 165-168 adenylate kinase 1 Homo sapiens 149-153 35625598-9 2022 Our results provide the structural basis of hAK1 catalyzing ADP into ATP and AMP, and disclose the driving force that triggers the conformational transition of hAK1, which will deepen understanding of the molecular mechanisms of hAK1 functions. Adenosine Diphosphate 60-63 adenylate kinase 1 Homo sapiens 44-48 35625598-9 2022 Our results provide the structural basis of hAK1 catalyzing ADP into ATP and AMP, and disclose the driving force that triggers the conformational transition of hAK1, which will deepen understanding of the molecular mechanisms of hAK1 functions. Adenosine Diphosphate 60-63 adenylate kinase 1 Homo sapiens 160-164 35625598-9 2022 Our results provide the structural basis of hAK1 catalyzing ADP into ATP and AMP, and disclose the driving force that triggers the conformational transition of hAK1, which will deepen understanding of the molecular mechanisms of hAK1 functions. Adenosine Diphosphate 60-63 adenylate kinase 1 Homo sapiens 229-233 34994069-6 2022 ADP@SWNT/TNFalpha inhibits tumor growth and metastasis both in vivo and in vitro, and the anti-tumor effect is enhanced by NIR irradiation, suggesting its high potential for application in tumor therapy. Adenosine Diphosphate 0-3 tumor necrosis factor Homo sapiens 9-17 35114687-4 2022 Inactive, ADP-bound NLRP3 is a decamer composed of homodimers of intertwined LRR domains that assemble back-to-back as pentamers. Adenosine Diphosphate 10-13 NLR family pyrin domain containing 3 Homo sapiens 20-25 35490399-6 2022 In vitro study suggests that OG-5 inhibited the release of inflammatory cytokines in endothelial cells and macrophage cells, migration of vascular smooth muscle cell induced by ADP, which is highly released in ApoE-/- mice. Adenosine Diphosphate 177-180 apolipoprotein E Mus musculus 210-214 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Diphosphate 18-21 tumor necrosis factor Homo sapiens 173-182 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Diphosphate 18-21 interleukin 6 Homo sapiens 334-338 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Diphosphate 18-21 C-X-C motif chemokine ligand 8 Homo sapiens 343-347 35290845-2 2022 In this study, we report the first ADP-competitive PKL inhibitors and identify several starting points for the further optimization of these inhibitors. Adenosine Diphosphate 35-38 pyruvate kinase L/R Homo sapiens 51-54 35290845-5 2022 Despite the difficulty involved in studying a binding site as exposed as the ADP site, these derivatives feature expanded structural diversity and chemical spaces that may be used to improve their inhibitory activities against PKL. Adenosine Diphosphate 77-80 pyruvate kinase L/R Homo sapiens 227-230 35290845-6 2022 The obtained results expand the knowledge of the structural requirements for interactions with the ADP-binding site of PKL. Adenosine Diphosphate 99-102 pyruvate kinase L/R Homo sapiens 119-122 35337572-4 2022 Green LED light treated sprouts contained the highest contents of ATP, ADP and AMP. Adenosine Diphosphate 71-74 small integral membrane protein 10 like 2A Homo sapiens 6-9 35134563-7 2022 ATP, ADP and AMP, the well-known energy carriers, regulate cellular responses to insulin outside cells through the purinergic receptors in cell surface. Adenosine Diphosphate 5-8 insulin Homo sapiens 81-88 35091759-7 2022 The blood metabolite analysis showed a stage-dependent inosine increase in COVID-19 patients, while the nucleotides ATP and ADP had positive correlations with fibrinogen and other coagulation proteins. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 159-169 35305713-7 2022 Mechanistic studies revealed that the platelet adenosine diphosphate (ADP) receptor P2Y12 is essential for canine platelet aggregation induced by canine cancer. Adenosine Diphosphate 70-73 purinergic receptor P2Y12 Canis lupus familiaris 84-89 35294260-6 2022 In vitro, P2X7R+ CD8 T cells were susceptible to ART1-mediated ADP-ribosylation and NICD, which was exacerbated upon blockade of the NAD+-degrading ADP-ribosyl cyclase CD38. Adenosine Diphosphate 63-66 purinergic receptor P2X 7 Homo sapiens 10-15 35353230-8 2022 We found that ADP acts as a danger signal for the hematopoietic BM and fosters emergency hematopoiesis by promoting Akt phosphorylation and cell cycle progression. Adenosine Diphosphate 14-17 thymoma viral proto-oncogene 1 Mus musculus 116-119 35294260-6 2022 In vitro, P2X7R+ CD8 T cells were susceptible to ART1-mediated ADP-ribosylation and NICD, which was exacerbated upon blockade of the NAD+-degrading ADP-ribosyl cyclase CD38. Adenosine Diphosphate 63-66 ADP-ribosyltransferase 1 Homo sapiens 49-53 35183932-7 2022 SsnB increased production of the vasodilator nitric oxide and suppressed secretion of the vasoconstrictor endothelin-1 from ADP- or U46619-treated human umbilical vein endothelial cells. Adenosine Diphosphate 124-127 endothelin 1 Homo sapiens 106-118 35253142-6 2022 Treatment of platelets with cucurbitacins resulted in attenuation of platelet aggregation, secretion and fibrinogen binding following stimulation by ADP, TRAP6, collagen and CRP-XL. Adenosine Diphosphate 149-152 fibrinogen beta chain Homo sapiens 105-115 35191835-4 2022 We found that iPSC-microglia lacking TREM2 (TREM2 KO) show exaggerated Ca2+ signals in response to purinergic agonists, such as ADP, that shape microglial injury responses. Adenosine Diphosphate 128-131 triggering receptor expressed on myeloid cells 2 Homo sapiens 37-42 35191835-4 2022 We found that iPSC-microglia lacking TREM2 (TREM2 KO) show exaggerated Ca2+ signals in response to purinergic agonists, such as ADP, that shape microglial injury responses. Adenosine Diphosphate 128-131 triggering receptor expressed on myeloid cells 2 Homo sapiens 44-49 35191835-5 2022 This ADP hypersensitivity, driven by increased expression of P2Y12 and P2Y13 receptors, results in greater release of Ca2+ from the endoplasmic reticulum (ER) stores, which triggers sustained Ca2+ influx through Orai channels and alters cell motility in TREM2 KO microglia. Adenosine Diphosphate 5-8 triggering receptor expressed on myeloid cells 2 Homo sapiens 254-259 35191835-7 2022 Despite showing greater overall displacement, TREM2 KO microglia exhibit reduced directional chemotaxis along ADP gradients. Adenosine Diphosphate 110-113 triggering receptor expressed on myeloid cells 2 Homo sapiens 46-51 35095818-3 2021 The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. Adenosine Diphosphate 166-169 poly(ADP-ribose) polymerase 1 Homo sapiens 4-34 35095818-3 2021 The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. Adenosine Diphosphate 166-169 poly(ADP-ribose) polymerase 1 Homo sapiens 36-41 35095818-3 2021 The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. Adenosine Diphosphate 166-169 poly(ADP-ribose) polymerase 1 Homo sapiens 56-102 35095818-3 2021 The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. Adenosine Diphosphate 166-169 poly(ADP-ribose) polymerase 1 Homo sapiens 104-109 2558659-2 1989 Fibronectin causes: (i) a significant lowered cytoplasmic calcium movement in platelets activated both with low doses of thrombin and with ADP, (ii) a lowered decrease of the cAMP level induced by low thrombin, but not by ADP, (iii) a dramatic decrease of protein phosphorylation in low thrombin-treated platelets. Adenosine Diphosphate 139-142 fibronectin 1 Homo sapiens 0-11 35167096-9 2022 The liberated creatine can then engage mitochondrial CKB to trigger another round of this cycle to support ADP-dependent respiration. Adenosine Diphosphate 107-110 creatine kinase B Homo sapiens 53-56 35054930-0 2022 Neutrophil Cathepsin G Enhances Thrombogenicity of Mildly Injured Arteries via ADP-Mediated Platelet Sensitization. Adenosine Diphosphate 79-82 cathepsin G Mus musculus 11-22 35054930-6 2022 In human and murine blood, aggregations by 0.05-0.1 U/mL cathepsin G were similar and not PAR-mediated, but platelet aggregation was inhibited by ADP antagonists, advocating cathepsin G-released ADP in blood as the true agonist of sustained platelet activation. Adenosine Diphosphate 195-198 cathepsin G Mus musculus 57-68 35054930-6 2022 In human and murine blood, aggregations by 0.05-0.1 U/mL cathepsin G were similar and not PAR-mediated, but platelet aggregation was inhibited by ADP antagonists, advocating cathepsin G-released ADP in blood as the true agonist of sustained platelet activation. Adenosine Diphosphate 195-198 cathepsin G Mus musculus 174-185 35054930-8 2022 This study shows that cathepsin G and elastase secreted in the circulation during mild air pollution-induced lung inflammation lyse red blood cell membrane proteins, leading to ADP-leakage into plasma, sensitizing platelets and amplifying their contribution to cardiovascular complications of ambient particle inhalation. Adenosine Diphosphate 177-180 cathepsin G Mus musculus 22-33 35593054-1 2022 Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y1,12,13 receptors. Adenosine Diphosphate 92-95 purinergic receptor P2Y1 Rattus norvegicus 121-125 2512294-6 1989 When membrane Gi-alpha [32P]ADP-ribosylated by CT plus fMLP or IAP was digested with trypsin, the radiolabeled fragments arising from the two proteins were different from each other. Adenosine Diphosphate 28-31 formyl peptide receptor 1 Homo sapiens 55-59 2512294-8 1989 CT-induced and fMLP-supported ADP-ribosylation of Gi-alpha was favored by Mg2+ and allow concentrations of GTP or its analogues but suppressed by GDP. Adenosine Diphosphate 30-33 formyl peptide receptor 1 Homo sapiens 15-19 2691968-3 1989 It is mediated by the binding of bifunctional molecules of fibrinogen to the plasma membrane of adjacent platelets, following stimulation of the platelets by agonists such as ADP, thrombin or collagen, with the fibrinogen serving as an intercellular glue. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 59-69 2513184-4 1989 Starvation of Hepa cells for tryptophan or glucose stimulated the relative rate of synthesis, and the ADP-ribosylation of GRP78. Adenosine Diphosphate 102-105 heat shock protein 5 Mus musculus 122-127 2532267-4 1989 In patients with nephrotic syndrome EC50 ADP values were significantly correlated to serum albumin, serum cholesterol and plasma fibrinogen, however, EC50 collagen or threshold AA did not correlate to these parameters. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 129-139 2691968-3 1989 It is mediated by the binding of bifunctional molecules of fibrinogen to the plasma membrane of adjacent platelets, following stimulation of the platelets by agonists such as ADP, thrombin or collagen, with the fibrinogen serving as an intercellular glue. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 211-221 2674130-11 1989 Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin. Adenosine Diphosphate 91-94 Rac family small GTPase 2 Homo sapiens 67-71 2511846-1 1989 Insulin inhibited the ability of activated pertussis toxin to catalyse the ADP-ribosylation of alpha-Gi in isolated plasma membranes in either the absence of added guanine nucleotides or in the presence of GTP. Adenosine Diphosphate 75-78 insulin Homo sapiens 0-7 2478231-8 1989 High concentrations (0.5 to 1 mmol/L) of synthetic peptide gamma 57.5 405-416 only weakly inhibited ADP-induced platelet aggregation supported by either fibrinogen gamma 50 or gamma 57.5. Adenosine Diphosphate 100-103 fibrinogen beta chain Homo sapiens 153-163 2478231-9 1989 Binding of fibrinogen gamma 50 (IC50 = 780 mumol/L) or gamma 57.5 (IC50 = 650 mumol/L) to ADP-stimulated platelets was weakly inhibited, and MoAb L2B failed to inhibit fibrinogen gamma 57.5 binding. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 11-21 2555322-4 1989 Preincubation of turkey erythrocytes with the P2Y-purinergic receptor agonist ADP beta S resulted in a marked loss of capacity of ADP beta S plus GTP to stimulate phospholipase C in membranes derived from these cells. Adenosine Diphosphate 78-81 P2Y purinoceptor 1 Meleagris gallopavo 46-69 2555322-4 1989 Preincubation of turkey erythrocytes with the P2Y-purinergic receptor agonist ADP beta S resulted in a marked loss of capacity of ADP beta S plus GTP to stimulate phospholipase C in membranes derived from these cells. Adenosine Diphosphate 130-133 P2Y purinoceptor 1 Meleagris gallopavo 46-69 2529923-4 1989 We studied native and ASA-treated platelets for their ability to mobilize and to express platelet-vWF in response to adenosine diphosphate (ADP) or thrombin. Adenosine Diphosphate 117-138 von Willebrand factor Homo sapiens 98-101 2529923-4 1989 We studied native and ASA-treated platelets for their ability to mobilize and to express platelet-vWF in response to adenosine diphosphate (ADP) or thrombin. Adenosine Diphosphate 140-143 von Willebrand factor Homo sapiens 98-101 2529923-7 1989 Measurement of secreted platelet-vWF and beta-thromboglobulin indicated that the increase seen with ADP was largely independent of alpha-granule secretion. Adenosine Diphosphate 100-103 von Willebrand factor Homo sapiens 33-36 2529923-8 1989 Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. Adenosine Diphosphate 153-156 von Willebrand factor Homo sapiens 186-189 2529923-8 1989 Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. Adenosine Diphosphate 153-156 von Willebrand factor Homo sapiens 274-277 2529923-9 1989 In contrast, the increase in platelet-vWF that occurred following ADP stimulation of ASA-treated platelets was largely insensitive to GPIIb/IIIa blockade. Adenosine Diphosphate 66-69 von Willebrand factor Homo sapiens 38-41 2529923-11 1989 When platelet shape change was prevented by the addition of cytochalasin D, ADP-induced platelet-vWf surface expression on ASA-treated platelets was reduced by more than 80%. Adenosine Diphosphate 76-79 von Willebrand factor Homo sapiens 97-100 2554951-6 1989 All Lassa samples which inhibited the ADP-induced aggregation responses of normal platelets inhibited the neutrophil response to FMLP. Adenosine Diphosphate 38-41 formyl peptide receptor 1 Homo sapiens 129-133 2527238-4 1989 Antibodies raised against a synthetic peptide WTVPTA (Trp-Thr-Val-Pro-Thr-Ala) deduced from the cloned rat FN RGDS domain block ADP-mediated platelet aggregation; this block can be overcome by additional fibrinogen. Adenosine Diphosphate 128-131 fibrinogen beta chain Homo sapiens 204-214 2617081-1 1989 Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67). Adenosine Diphosphate 47-50 insulin like growth factor binding protein 7 Homo sapiens 189-192 2617081-1 1989 Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67). Adenosine Diphosphate 47-50 insulin like growth factor binding protein 7 Homo sapiens 258-261 2617081-1 1989 Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67). Adenosine Diphosphate 47-50 insulin like growth factor binding protein 7 Homo sapiens 258-261 2792373-6 1989 Phosphorylated and ADP-ribosylated forms of EF-2 could be ADP-ribosylated and phosphorylated, respectively, but a native form both ADP-ribosylated and phosphorylated was not detected. Adenosine Diphosphate 19-22 eukaryotic translation elongation factor 2 Rattus norvegicus 44-48 2792373-6 1989 Phosphorylated and ADP-ribosylated forms of EF-2 could be ADP-ribosylated and phosphorylated, respectively, but a native form both ADP-ribosylated and phosphorylated was not detected. Adenosine Diphosphate 58-61 eukaryotic translation elongation factor 2 Rattus norvegicus 44-48 2792373-6 1989 Phosphorylated and ADP-ribosylated forms of EF-2 could be ADP-ribosylated and phosphorylated, respectively, but a native form both ADP-ribosylated and phosphorylated was not detected. Adenosine Diphosphate 58-61 eukaryotic translation elongation factor 2 Rattus norvegicus 44-48 2547780-13 1989 In broken Balb/c3T3 cell membranes, 10 nM IGF-II rapidly attenuated the IAP-catalyzed ADP-ribosylation of a 40-kDa protein in a manner requiring magnesium ion. Adenosine Diphosphate 86-89 intracisternal A particle, Eya1 linked Mus musculus 72-75 2551347-2 1989 Thrombin elicited the formation of considerably more [32P]phosphatidic acid (an index of phospholipase C catalysed phosphoinositide metabolism) than did platelet activating factor, 5-hydroxytryptamine, ADP, and the thromboxane A2 analogue EP171, when these agents were added either alone or in combination. Adenosine Diphosphate 202-205 coagulation factor II, thrombin Homo sapiens 0-8 2765399-0 1989 Association of fibrinogen with human platelets pretreated with chymotrypsin or aggregated with ADP or thrombin: an immunocytochemical study. Adenosine Diphosphate 95-98 fibrinogen beta chain Homo sapiens 15-25 2765399-5 1989 ADP-induced aggregation was associated with pseudopod formation and fibrinogen binding; granule contents were not released and aggregation and fibrinogen binding were reversible. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 68-78 2765399-5 1989 ADP-induced aggregation was associated with pseudopod formation and fibrinogen binding; granule contents were not released and aggregation and fibrinogen binding were reversible. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 143-153 2765399-7 1989 Fibrinogen-induced aggregation/agglutination of chymotrypsin-treated platelets was similar to ADP-induced aggregation in that fibrinogen binding was required and granule contents were not released; it differed from ADP-induced aggregation in that pseudopod formation did not occur and the aggregates were irreversible. Adenosine Diphosphate 215-218 fibrinogen beta chain Homo sapiens 0-10 2525930-8 1989 In many tissues, it has been shown that the binding of hexokinase to the mitochondrial outer membrane allows a preferential utilization of the ATP generated by oxidative phosphorylation which, in turn, is activated by immediate restitution of ADP. Adenosine Diphosphate 243-246 hexokinase 1 Homo sapiens 55-65 2741922-12 1989 Platelets from patients in crisis were able to release their remaining granular ADP in response to thrombin as effectively as normal platelets. Adenosine Diphosphate 80-83 coagulation factor II, thrombin Homo sapiens 99-107 2526667-9 1989 The data suggest that ADP-induced fibrinogen binding to fresh platelets is accompanied by progressive rearrangements of fibrinogen on the platelet surface. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 34-44 2526667-9 1989 The data suggest that ADP-induced fibrinogen binding to fresh platelets is accompanied by progressive rearrangements of fibrinogen on the platelet surface. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 120-130 2620270-3 1989 As to the effect of the four McAbs on platelet aggregation, the results showed: 1) HIP4 and HIP8 can completely inhibit platelet aggregation induced by ADP or collagen, but not that induced by thrombin or ristocetin. Adenosine Diphosphate 152-155 cystathionine beta-synthase Homo sapiens 83-87 2786916-1 1989 When platelets are stimulated with adenosine diphosphate (ADP), thrombin, or ristocetin, they bind soluble von Willebrand factor (vWF). Adenosine Diphosphate 35-56 von Willebrand factor Homo sapiens 107-128 2765407-0 1989 Heterogeneity of fibrinogen receptor expression on platelets activated in normal plasma with ADP: analysis by flow cytometry. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 17-27 2765407-1 1989 Fibrinogen receptor expression of platelets activated in normal plasma by ADP was measured by flow cytometry after labelling bound fibrinogen with fluorescein-conjugated antifibrinogen antibody. Adenosine Diphosphate 74-77 fibrinogen beta chain Homo sapiens 0-10 2765407-2 1989 The platelet response to ADP was heterogeneous both with respect to number of platelets binding fibrinogen and the amount of fibrinogen bound per platelet. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 96-106 2765407-2 1989 The platelet response to ADP was heterogeneous both with respect to number of platelets binding fibrinogen and the amount of fibrinogen bound per platelet. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 125-135 2765407-3 1989 The proportion of platelets showing positive antifibrinogen antibody binding increased with increasing ADP concentration; however, even at 10(-3) M ADP, usually about one-fifth of the platelets failed to demonstrate bound fibrinogen. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 49-59 2765407-5 1989 The relative fluorescence intensity of individual platelets also increased as ADP concentration was increased, indicating that the average number of fibrinogen molecules bound was also related to agonist concentration. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 149-159 2765407-7 1989 This study demonstrates that platelet response to ADP in native plasma is heterogeneous in both the proportion of platelets activated and in the number of available fibrinogen receptors per platelet. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 165-175 2526132-14 1989 Fibrinogen binding to ADP-stimulated platelets was increased twofold by Zn++ (50 microM) and was inhibited by HMWK. Adenosine Diphosphate 22-25 fibrinogen beta chain Homo sapiens 0-10 2526132-14 1989 Fibrinogen binding to ADP-stimulated platelets was increased twofold by Zn++ (50 microM) and was inhibited by HMWK. Adenosine Diphosphate 22-25 kininogen 1 Homo sapiens 110-114 2738154-5 1989 These subfractions also exhibited decreased (12-50% of normal controls, fibrinogen 30-590 nM, n = 5) ADP-induced aggregation support of gel-sieved platelets, a decrease not demonstrable by whole phi SB, by fibrinogen from the homozygous proband, or by enrichment of the latter with normal soluble fibrin. Adenosine Diphosphate 101-104 fibrinogen beta chain Homo sapiens 72-82 2738154-5 1989 These subfractions also exhibited decreased (12-50% of normal controls, fibrinogen 30-590 nM, n = 5) ADP-induced aggregation support of gel-sieved platelets, a decrease not demonstrable by whole phi SB, by fibrinogen from the homozygous proband, or by enrichment of the latter with normal soluble fibrin. Adenosine Diphosphate 101-104 fibrinogen beta chain Homo sapiens 206-216 2786916-1 1989 When platelets are stimulated with adenosine diphosphate (ADP), thrombin, or ristocetin, they bind soluble von Willebrand factor (vWF). Adenosine Diphosphate 35-56 von Willebrand factor Homo sapiens 130-133 2786916-1 1989 When platelets are stimulated with adenosine diphosphate (ADP), thrombin, or ristocetin, they bind soluble von Willebrand factor (vWF). Adenosine Diphosphate 58-61 von Willebrand factor Homo sapiens 107-128 2786916-1 1989 When platelets are stimulated with adenosine diphosphate (ADP), thrombin, or ristocetin, they bind soluble von Willebrand factor (vWF). Adenosine Diphosphate 58-61 von Willebrand factor Homo sapiens 130-133 2786916-11 1989 When used to stimulate the platelets, ADP, thrombin, and ristocetin all increased the platelet adhesion to solid-phase vWF. Adenosine Diphosphate 38-41 von Willebrand factor Homo sapiens 119-122 2786916-16 1989 In addition, these platelets can be stimulated to increase their adherence to vWF by using ADP, thrombin, and ristocetin. Adenosine Diphosphate 91-94 von Willebrand factor Homo sapiens 78-81 2505402-7 1989 Stimulation of the endothelial cells with bradykinin produced an unstable factor(s) that potentiated ADP-induced platelet aggregation, was not affected by hemoglobin or cyclooxygenase inhibitions, and had no platelet aggregatory activity on its own. Adenosine Diphosphate 101-104 kininogen 1 Homo sapiens 42-52 2545197-1 1989 Binding of ADP to platelets enhances the binding of fibrinogen to Gp IIb-IIIa, the specific platelet receptor for adhesive proteins. Adenosine Diphosphate 11-14 fibrinogen beta chain Homo sapiens 52-62 2545197-2 1989 The linkage between ADP and fibrinogen binding is indirect since ADP does not bind to the same receptor as fibrinogen. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 28-38 2545197-2 1989 The linkage between ADP and fibrinogen binding is indirect since ADP does not bind to the same receptor as fibrinogen. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 28-38 2545197-3 1989 We have recently proposed that a third component, once affected by ADP binding, induces a conformational transition of the fibrinogen receptor from the low to the high affinity state, which is responsible for platelet aggregation [De Cristofaro, R., Landolfi, R., Castagnola, M., De Candia, E., Di Cera, E., & Wyman, J. Adenosine Diphosphate 67-70 fibrinogen beta chain Homo sapiens 123-133 2730887-10 1989 Studies with isolated lung mitochondria suggest that CCl4 inhibits the enzyme complex which catalyzes the synthesis of ATP from ADP. Adenosine Diphosphate 128-131 C-C motif chemokine ligand 4 Rattus norvegicus 53-57 2773809-3 1989 We have used an immunogold-surface replica technique to study the distribution of GPIIb-IIIa and bound fibrinogen over broad expanses of surface membranes in unstimulated and ADP-activated human platelets. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 103-113 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 207-217 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 fibrinogen beta chain Homo sapiens 284-294 2799757-3 1989 The receptor capacity for fibrinogen in platelets activated by ADP was significantly higher (p less than 0.01) in migraine patients (52,505 +/- 4,925) than in controls (33,881 +/- 3,965). Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 26-36 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). Adenosine Diphosphate 68-71 fibrinogen beta chain Homo sapiens 153-163 2543293-1 1989 5"-p-Fluorosulfonylbenzoyl adenosine (FSBA), a nucleotide analog of ADP, has been shown to inhibit ADP-induced shape change, aggregation and exposure of fibrinogen binding sites concomitant with covalent modification of a single surface membrane polypeptide of Mr 100,000 (aggregin). Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 153-163 2543293-3 1989 At a low concentration of thrombin (0.05 U/ml), platelet aggregation, exposure of fibrinogen receptors and cleavage of aggregin in FSBA-modified platelets did not occur, indicating ADP dependence. Adenosine Diphosphate 181-184 coagulation factor II, thrombin Homo sapiens 26-34 2542278-7 1989 3-Morpholinosydnonimine (commonly known as SIN-1) (20-1000 micrograms/ml), another compound that acts through the spontaneous formation of nitric oxide as does sodium nitroprusside, also stimulates ADP-ribosylation of the 39-kDa protein. Adenosine Diphosphate 198-201 MAPK associated protein 1 Homo sapiens 43-48 2503906-5 1989 CPIB blocked ADP and E-induced AGG and SEC (IC50"s greater than 1200 microM) but not AA- or U46619-induced responses. Adenosine Diphosphate 13-16 cystatin B Homo sapiens 0-4 2523213-12 1989 For ATP synthesis the inhibition constants were determined as 0.12 and 0.16 microM for Kis and Kii, respectively, when ADP concentration was kept saturating. Adenosine Diphosphate 119-122 U2AF homology motif kinase 1 Homo sapiens 87-90 2501664-8 1989 The results demonstrate that TNF secretion is regulated by at least two distinct guanine nucleotide-binding proteins, one responsible for the activation of phospholipase C and another which acts as a substrate for botulinum toxin type D. ADP-ribosylation of monocyte membranes by botulinum toxin type D demonstrated the presence of three substrates with Mrs of 45,000, 21,000, and 17,000. Adenosine Diphosphate 238-241 tumor necrosis factor Homo sapiens 29-32 2551298-1 1989 Adenylate kinase isozyme 1 (AK1) catalyzes thiamin triphosphate (TTP) formation from thiamin diphosphate (TDP) and ADP. Adenosine Diphosphate 115-118 adenylate kinase 1 Homo sapiens 0-26 2551298-1 1989 Adenylate kinase isozyme 1 (AK1) catalyzes thiamin triphosphate (TTP) formation from thiamin diphosphate (TDP) and ADP. Adenosine Diphosphate 115-118 adenylate kinase 1 Homo sapiens 28-31 2742818-1 1989 We have previously shown that the alpha chain of human fibrinogen interacts directly with ADP-activated human platelets [Hawiger, J., Timmons, S., Kloczewiak, M., Strong, D. D., & Doolittle, R. F. (1982) Proc. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 55-65 2797903-1 1989 The authors studied thrombin-induced aggregation of blood platelets washed clean of plasma and some parameters of their energetic status (content of ATP, ADP, and glycogen) in rats with acute vasorenal hypertension (AVH). Adenosine Diphosphate 154-157 coagulation factor II Rattus norvegicus 20-28 2773059-0 1989 [Ultrastructural changes of platelets during ADP- stimulated aggregation (in the presence of fibrinogen)]. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 93-103 2495280-1 1989 Analogs of ATP and ADP produce a guanine nucleotide-dependent activation of phospholipase C in turkey erythrocyte membranes with pharmacological properties consistent with those of a P2y-purinergic receptor (Boyer, J. L., Downes, C. P., and Harden, T.K. Adenosine Diphosphate 19-22 P2Y purinoceptor 1 Meleagris gallopavo 183-206 2742818-7 1989 They encompass residues 92-147 and 518-584, which inhibit 125I-fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 85-88 fibrinogen beta chain Homo sapiens 63-73 2742818-10 1989 The synthetic peptide RGDF, corresponding to residues alpha 95-98, inhibited the binding of 125I-fibrinogen to ADP-treated platelets (IC50 = 2 microM). Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 97-107 2742820-4 1989 Peptide gamma 400-411 (HHLGGAKQAGDV) inhibited aggregation of ADP-treated platelets mediated not only by gamma-chain but also by alpha-chain multimers. Adenosine Diphosphate 62-65 Fc gamma receptor and transporter Homo sapiens 129-140 2655704-8 1989 At 0 degree C and 1 bar ATP and ADP decreased the stability of the GAPDH tetramer by changes in free energy of association of +3.7 and +4.1 kcal mol-1, respectively. Adenosine Diphosphate 32-35 thiamine thiazole synthase Saccharomyces cerevisiae S288C 145-150 2498343-11 1989 Since GP IIIa incorporation caused by ADP-induced aggregation differs from that caused by Con A in its susceptibility to MB, it seems unlikely that thiol groups are directly involved in the association of GP IIIa with the cytoskeletal core. Adenosine Diphosphate 38-41 integrin subunit beta 3 Homo sapiens 6-13 2537867-4 1989 In addition, the ability of ATP, ADP, and AMP to limit neutrophil O2- generation induced by FMLP (0.2 to 0.5 microM) was demonstrated. Adenosine Diphosphate 33-36 formyl peptide receptor 1 Homo sapiens 92-96 2537867-10 1989 Both TLC and HPLC confirmed that ATP and ADP were converted to AMP and ADO after their incubation with unstimulated or FMLP-activated neutrophils. Adenosine Diphosphate 41-44 formyl peptide receptor 1 Homo sapiens 119-123 2537867-12 1989 The kinetics of inhibition of FMLP-induced neutrophil O2- generation by ATP and ADP also indicated that conversion of these nucleotides to ADO and/or AMP may be essential for their ability to reduce neutrophil responses. Adenosine Diphosphate 80-83 formyl peptide receptor 1 Homo sapiens 30-34 2741653-5 1989 The 5-day-stored platelets stimulated with the combination of ADP and epinephrine scarcely bound fibrinogen, but did bind NNKY1-32. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 97-107 2521786-3 1989 The binding of PFK to actin is inhibited by ATP and ADP but not by fructose 6-phosphate or fructose 2,6-bisphosphate. Adenosine Diphosphate 52-55 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 15-18 2920065-4 1989 The hypersensitivity to thrombin-induced aggregation was independent of released ADP or products of arachidonic acid metabolism. Adenosine Diphosphate 81-84 coagulation factor II Rattus norvegicus 24-32 2741653-6 1989 On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine. Adenosine Diphosphate 248-251 fibrinogen beta chain Homo sapiens 64-74 2914136-5 1989 The rate of iron released from transferrin following addition of ATP and ADP in amounts equivalent to that present in platelet conditioned media was significantly less than the rate of iron released following the addition of conditioned media from platelets. Adenosine Diphosphate 73-76 transferrin Homo sapiens 31-42 2463985-4 1989 In addition, phosphorylated EGF receptor can be rapidly dephosphorylated in the presence of ADP. Adenosine Diphosphate 92-95 epidermal growth factor receptor Homo sapiens 28-40 2914136-6 1989 Depletion of ATP and ADP in platelet conditioned media by incubation with apyrase only partially inhibited their ability to enhance the rate of iron release from transferrin. Adenosine Diphosphate 21-24 transferrin Homo sapiens 162-173 2506561-4 1989 The glycosylated aldose reductase exhibits lower Km for glucose and NADPH as compared to unglycosylated enzyme and is not inhibited by phosphorylated intermediates such as ADP, 1,3-DPG, 2,3-DPG and 3-PGA, whereas physiological concentrations of these intermediates almost completely inhibit the unglycosylated enzyme. Adenosine Diphosphate 69-72 aldo-keto reductase family 1 member B Homo sapiens 17-33 2912385-3 1989 Purified rubisco activase hydrolyzed ATP with a specific activity of 1.5 mumol min-1 mg-1 protein, releasing approximately stoichiometric amounts of ADP and Pi. Adenosine Diphosphate 149-152 CD59 molecule (CD59 blood group) Homo sapiens 79-89 2731490-1 1989 A method for the purification of brain-type creatine kinase (B-CK) from several tissues of the chicken, e.g., brain, retina, gizzard and heart was developed involving (1) an affinity chromatography step on Sepharose Blue from which B-CK was specifically eluted by ADP and (2) a subsequent anion exchange chromatography step on a fast protein liquid chromatography Mono-Q column. Adenosine Diphosphate 264-267 creatine kinase B Gallus gallus 33-65 2731490-1 1989 A method for the purification of brain-type creatine kinase (B-CK) from several tissues of the chicken, e.g., brain, retina, gizzard and heart was developed involving (1) an affinity chromatography step on Sepharose Blue from which B-CK was specifically eluted by ADP and (2) a subsequent anion exchange chromatography step on a fast protein liquid chromatography Mono-Q column. Adenosine Diphosphate 264-267 creatine kinase B Gallus gallus 61-65 2540806-3 1989 In the absence of insulin, a noncovalent association of the alpha beta heterodimeric insulin receptor complex into an alpha 2 beta 2 heterotetrameric state required the continuous presence of both a divalent metal ion (Mn or Mg) and an adenine nucleotide (ATP, ADP, or AMPPCP). Adenosine Diphosphate 261-264 insulin Homo sapiens 85-92 3149505-3 1988 Myosin subfragment 1 (S1) can be specifically photomodified at the active site without polypeptide chain cleavage by irradiating the stable MgADP-orthovanadate-S1 complex with UV light above 300 nm [Grammer, J. C., Cremo, C. R., & Yount, R. G. (1988) Biochemistry (preceding paper in this issue)]. Adenosine Diphosphate 140-145 proteasome 26S subunit, non-ATPase 1 Homo sapiens 0-24 2904148-4 1988 Inhibition of isolated F1-type ATPase by AIF-4 in the presence of ADP cannot be reversed by ADP, ATP, or chelators of aluminum. Adenosine Diphosphate 66-69 itchy E3 ubiquitin protein ligase Homo sapiens 41-46 2904148-7 1988 Because of structural similarities between AIF4- and , AIF4- is postulated to mimic the phosphate group of ATP and form an abortive complex with ADP at the active site(s) of F1-type ATPase. Adenosine Diphosphate 145-148 itchy E3 ubiquitin protein ligase Homo sapiens 43-47 2904148-7 1988 Because of structural similarities between AIF4- and , AIF4- is postulated to mimic the phosphate group of ATP and form an abortive complex with ADP at the active site(s) of F1-type ATPase. Adenosine Diphosphate 145-148 itchy E3 ubiquitin protein ligase Homo sapiens 55-59 3049815-2 1988 It has been shown previously that CD11b/CD18 on cells of monocyte and myeloid lineage appears to undergo rapid activation and acquire new functional receptor specificities after exposure to selected agonists such as adenosine diphosphate (ADP). Adenosine Diphosphate 216-237 integrin subunit beta 2 Homo sapiens 40-44 3140912-6 1988 At a concentration of 10 micrograms IgG/mL, PP3-3A completely inhibited binding either of 125I-fibrinogen or of 125I-vWF to ADP-stimulated platelets. Adenosine Diphosphate 124-127 von Willebrand factor Homo sapiens 117-120 3183492-5 1988 Unlike aggregation, ADP-induced phosphorylations of both MLC and the 47 kd protein were inhibited rather than potentiated by epinephrine. Adenosine Diphosphate 20-23 modulator of VRAC current 1 Homo sapiens 57-60 3216242-4 1988 Release of Ang II was greater with thrombin (40.7%) than with ADP (29%), while N-ethylmaleimide was almost ineffective. Adenosine Diphosphate 62-65 angiotensinogen Homo sapiens 11-17 3049815-2 1988 It has been shown previously that CD11b/CD18 on cells of monocyte and myeloid lineage appears to undergo rapid activation and acquire new functional receptor specificities after exposure to selected agonists such as adenosine diphosphate (ADP). Adenosine Diphosphate 239-242 integrin subunit beta 2 Homo sapiens 40-44 3049815-3 1988 We now show that ADP induces a reconformation of the CD11b/CD18 receptor with exposure of new epitopes characteristics of this activated state. Adenosine Diphosphate 17-20 integrin subunit beta 2 Homo sapiens 59-63 3049815-5 1988 The activated state of CD11b/CD18 induced by ADP and recognized by 7E3 can also be recapitulated by agonists inducing transients in cytosolic Ca2+ such as the chemoattractant FMLP. Adenosine Diphosphate 45-48 integrin subunit beta 2 Homo sapiens 29-33 3049815-5 1988 The activated state of CD11b/CD18 induced by ADP and recognized by 7E3 can also be recapitulated by agonists inducing transients in cytosolic Ca2+ such as the chemoattractant FMLP. Adenosine Diphosphate 45-48 formyl peptide receptor 1 Homo sapiens 175-179 3207715-4 1988 Using three methods to determine the extramitochondrial ATP/ADP ratio, we observed that at high ATP/ADP ratios the relationship between respiratory rate and log (ATP/ADP) deviated in a sigmoidal fashion from linearity, if the amount of hexokinase present was modulated. Adenosine Diphosphate 100-103 hexokinase 1 Homo sapiens 236-246 2844854-2 1988 Treatment of human neutrophils with botulinum C2 toxin for 45 min increased FMLP-stimulated superoxide anion (O2-) production 1.5-5-fold, whereas only a minor fraction of the cellular actin pool (approximately 20%) was ADP-ribosylated. Adenosine Diphosphate 219-222 formyl peptide receptor 1 Homo sapiens 76-80 3207715-4 1988 Using three methods to determine the extramitochondrial ATP/ADP ratio, we observed that at high ATP/ADP ratios the relationship between respiratory rate and log (ATP/ADP) deviated in a sigmoidal fashion from linearity, if the amount of hexokinase present was modulated. Adenosine Diphosphate 60-63 hexokinase 1 Homo sapiens 236-246 3207715-4 1988 Using three methods to determine the extramitochondrial ATP/ADP ratio, we observed that at high ATP/ADP ratios the relationship between respiratory rate and log (ATP/ADP) deviated in a sigmoidal fashion from linearity, if the amount of hexokinase present was modulated. Adenosine Diphosphate 100-103 hexokinase 1 Homo sapiens 236-246 2843248-0 1988 The role of fibrinogen A alpha chains in ADP-induced platelet aggregation in the presence of fibrinogen molecules containing gamma" chains. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 12-22 3263711-1 1988 Native von Willebrand factor (N-vWF) binds to platelets activated by thrombin, ADP or ristocetin. Adenosine Diphosphate 79-82 von Willebrand factor Homo sapiens 32-35 2971572-4 1988 It is concluded that caldesmon inhibits by slowing the rate-limiting release of products from the actin-HMM[SP].ADP.Pi complex. Adenosine Diphosphate 112-115 caldesmon 1 Homo sapiens 21-30 3415675-5 1988 Adenosine diphosphate, at concentrations which induce only the first phase of aggregation and not the release reaction, caused only a minor release of neuropeptide Y. Adenosine Diphosphate 0-21 neuropeptide Y Rattus norvegicus 151-165 2843248-2 1988 In this study, we compared the contribution to adenosine diphosphate (ADP)-induced platelet aggregation of the A alpha chains in Fgn molecules containing predominantly (fraction 1-2) or exclusively (peak 1 Fgn) gammaA chains with that of molecules containing approximately 50% gamma" chains (peak 2 Fgn). Adenosine Diphosphate 47-68 fibrinogen beta chain Homo sapiens 129-132 2843248-2 1988 In this study, we compared the contribution to adenosine diphosphate (ADP)-induced platelet aggregation of the A alpha chains in Fgn molecules containing predominantly (fraction 1-2) or exclusively (peak 1 Fgn) gammaA chains with that of molecules containing approximately 50% gamma" chains (peak 2 Fgn). Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 129-132 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 123-126 fibrinogen beta chain Homo sapiens 69-72 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 308-311 fibrinogen beta chain Homo sapiens 69-72 2839480-12 1988 In any event, inhibition of the TNF-induced increase in GTPase activity and ADP-ribosylation of Gi by pertussis toxin suggested that TNF might act by increasing GTPase activity of the Gi protein. Adenosine Diphosphate 76-79 tumor necrosis factor Mus musculus 32-35 2900240-2 1988 Saturation curves for glutamine synthetase activity versus ATP with ADP as the changing fixed inhibitor were not hyperbolic; greater apparent Vmax values were observed in the presence of added ADP than the Vmax observed in the absence of ADP. Adenosine Diphosphate 193-196 glutamate-ammonia ligase Homo sapiens 22-42 2900240-2 1988 Saturation curves for glutamine synthetase activity versus ATP with ADP as the changing fixed inhibitor were not hyperbolic; greater apparent Vmax values were observed in the presence of added ADP than the Vmax observed in the absence of ADP. Adenosine Diphosphate 193-196 glutamate-ammonia ligase Homo sapiens 22-42 2900240-10 1988 A Vmax value of 1.55 units/mg was measured for glutamine synthetase with one ADP tightly bound per enzyme subunit; a Vmax value of 0.8 unit/mg was measured for enzyme with no adenine nucleotide bound at the allosteric site. Adenosine Diphosphate 77-80 glutamate-ammonia ligase Homo sapiens 47-67 2900240-14 1988 ADP was a simple competitive inhibitor (Ki = 0.05 mM) of ATP for glutamine synthetase with eight molecules of ADP tightly bound to the allosteric sites of the octamer. Adenosine Diphosphate 0-3 glutamate-ammonia ligase Homo sapiens 65-85 2900240-14 1988 ADP was a simple competitive inhibitor (Ki = 0.05 mM) of ATP for glutamine synthetase with eight molecules of ADP tightly bound to the allosteric sites of the octamer. Adenosine Diphosphate 110-113 glutamate-ammonia ligase Homo sapiens 65-85 2845933-3 1988 In combination with GTP[S], these hormones potentiate the response to GTP[S], indicating the existence of a G-protein involved in the coupling of the VP and AT II receptor with the phospholipase C. ADP-ribosylation with pertussis toxin (IAP) revealed the specific labelling of a single molecule of 41 kDa. Adenosine Diphosphate 198-201 angiotensinogen Rattus norvegicus 157-162 2839480-12 1988 In any event, inhibition of the TNF-induced increase in GTPase activity and ADP-ribosylation of Gi by pertussis toxin suggested that TNF might act by increasing GTPase activity of the Gi protein. Adenosine Diphosphate 76-79 tumor necrosis factor Mus musculus 133-136 3291978-0 1988 KRDS--a tetrapeptide derived from lactotransferrin--inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-stimulated platelets and megakaryocytes. Adenosine Diphosphate 125-128 lactotransferrin Homo sapiens 34-50 2455569-6 1988 The role of secreted ADP and thromboxane in fibrinogen-binding and subsequent platelet aggregation was studied using creatine phosphate/creatine phosphokinase (CP/CPK) and aspirin. Adenosine Diphosphate 21-24 fibrinogen beta chain Homo sapiens 44-54 2455569-9 1988 These results demonstrate that the binding of IgG molecules to the CD9 antigen exposes fibrinogen receptors through both secreted ADP and thromboxane and that either one of both can expose the receptors to an extent sufficient to aggregate platelets. Adenosine Diphosphate 130-133 fibrinogen beta chain Homo sapiens 87-97 2967866-7 1988 Inhibition of FMLP responses and Fc gamma R42-mediated superoxide production, but not degranulation, correlated with ADP-ribosylation of a 45-kDa membrane protein. Adenosine Diphosphate 117-120 formyl peptide receptor 1 Homo sapiens 14-18 2460179-4 1988 Prostaglandin D2 (PGD2), BW245C, 9 alpha, 11 beta-PGF2, PGI2 and 5"-N-ethylcarboxamide adenosine (NECA) all inhibited ADP-induced platelet aggregation in whole blood. Adenosine Diphosphate 118-121 prostaglandin D2 synthase Homo sapiens 0-16 2460179-4 1988 Prostaglandin D2 (PGD2), BW245C, 9 alpha, 11 beta-PGF2, PGI2 and 5"-N-ethylcarboxamide adenosine (NECA) all inhibited ADP-induced platelet aggregation in whole blood. Adenosine Diphosphate 118-121 prostaglandin D2 synthase Homo sapiens 18-22 3390605-1 1988 Thrombospondin (TSP), isolated from human platelets, promotes aggregation of both nonstimulated platelets and platelets stimulated with thrombin or ADP. Adenosine Diphosphate 148-151 thrombospondin 1 Homo sapiens 0-14 3390605-1 1988 Thrombospondin (TSP), isolated from human platelets, promotes aggregation of both nonstimulated platelets and platelets stimulated with thrombin or ADP. Adenosine Diphosphate 148-151 thrombospondin 1 Homo sapiens 16-19 2968367-4 1988 When dense-granule constituents (ADP, ATP, serotonin, Ca+2, pyrophosphate) were added to gel-filtered platelets, ADP, but none of the other constituents, completely corrected the impairment of thrombin and A23187-induced secretion in SPD platelets. Adenosine Diphosphate 113-116 coagulation factor II, thrombin Homo sapiens 193-201 2967329-2 1988 TNF caused a time- and dose-dependent increase of ADP-ribosylation in L929 target cells parallel to cell death. Adenosine Diphosphate 50-53 tumor necrosis factor Mus musculus 0-3 2967329-3 1988 During the course of TNF-mediated cytotoxicity in the presence of actinomycin D, an increase in ADP-ribosylation became apparent between 4 and 6 h after exposure to TNF. Adenosine Diphosphate 96-99 tumor necrosis factor Mus musculus 21-24 2967329-3 1988 During the course of TNF-mediated cytotoxicity in the presence of actinomycin D, an increase in ADP-ribosylation became apparent between 4 and 6 h after exposure to TNF. Adenosine Diphosphate 96-99 tumor necrosis factor Mus musculus 165-168 2967329-6 1988 Another target, the human cervical carcinoma cell line ME-180, showed an increase in ADP-ribosylation when treated with TNF, and the cytotoxic action of TNF on this target cell was inhibited by these two inhibitors. Adenosine Diphosphate 85-88 tumor necrosis factor Homo sapiens 120-123 2967329-6 1988 Another target, the human cervical carcinoma cell line ME-180, showed an increase in ADP-ribosylation when treated with TNF, and the cytotoxic action of TNF on this target cell was inhibited by these two inhibitors. Adenosine Diphosphate 85-88 tumor necrosis factor Homo sapiens 153-156 2967329-7 1988 In the absence of actinomycin D, treatment of L929 cells with TNF also increased ADP-ribosylation, and the cytotoxic action of TNF was inhibited by nicotinamide. Adenosine Diphosphate 81-84 tumor necrosis factor Mus musculus 62-65 2967329-7 1988 In the absence of actinomycin D, treatment of L929 cells with TNF also increased ADP-ribosylation, and the cytotoxic action of TNF was inhibited by nicotinamide. Adenosine Diphosphate 81-84 tumor necrosis factor Mus musculus 127-130 2968367-5 1988 The concentration of ADP required to normalize thrombin-induced secretion varied markedly, from 0.01 to 10 microM, among the individual patients. Adenosine Diphosphate 21-24 coagulation factor II, thrombin Homo sapiens 47-55 2847246-7 1988 Generally, the receptor affinities correlate with the activities as stimulators of adenylate cyclase and inhibitors of thrombin induced elevation of cytoplasmic free calcium as well as their ability to inhibit ADP-induced platelet aggregation. Adenosine Diphosphate 210-213 coagulation factor II, thrombin Homo sapiens 119-127 3133807-5 1988 Experimental animal studies confirmed the in vitro anti-aggregatory efficacy of SC 38249, since significant inhibitory activity was observed against Paf-acether and ADP-induced responses in dog PRP ex vivo, anti-Forssman antibody-induced thrombocytopenia in anaesthetized guinea pigs, and collagen-induced intravascular aggregation in anaesthetized rabbits. Adenosine Diphosphate 165-168 prion protein Canis lupus familiaris 194-197 2837182-5 1988 ADP similarly induced pHi changes, whereas AMP and adenosine were inactive. Adenosine Diphosphate 0-3 glucose-6-phosphate isomerase Bos taurus 22-25 3291947-4 1988 Paradoxically, adenosine 5"-triphosphate (ATP), or AMPPCP, in the absence of glucose destabilizes the association by +0.34 kcal mol-1, while adenosine 5"-diphosphate (ADP) stabilizes it by -0.6 kcal mol-1. Adenosine Diphosphate 141-165 thiamine thiazole synthase Saccharomyces cerevisiae S288C 199-204 3258770-0 1988 Shear-induced platelet aggregation can be mediated by vWF released from platelets, as well as by exogenous large or unusually large vWF multimers, requires adenosine diphosphate, and is resistant to aspirin. Adenosine Diphosphate 156-177 von Willebrand factor Homo sapiens 132-135 3350811-4 1988 Half-maximal protection by Mg2+-ADP was enhanced by calmodulin which decreased the K0.5 for ADP from 540 to 61 microM. Adenosine Diphosphate 32-35 calmodulin 1 Homo sapiens 52-62 3388301-4 1988 Although no fibrinogen was detected on human platelets either before or after treatment with ADP, fibrinogen was expressed on the surface of rabbit platelets after stimulation with ADP. Adenosine Diphosphate 181-184 fibrinogen beta chain Homo sapiens 98-108 3388301-0 1988 Expression of fibrinogen on the surface of ADP-stimulated platelets: comparison of human and rabbit platelets. Adenosine Diphosphate 43-46 fibrinogen beta chain Homo sapiens 14-24 3388301-1 1988 Fibrinogen is a cofactor in the aggregation of human platelets and must be added to suspensions of washed human platelets for extensive aggregation to occur in response to ADP. Adenosine Diphosphate 172-175 fibrinogen beta chain Homo sapiens 0-10 2833659-6 1988 Similar results were obtained in human neutrophils stimulated with immune complexes; when FMLP was the agonist, the results were divergent: ATP and ADP enhanced the responses, whereas AMP and adenosine were inhibitory. Adenosine Diphosphate 148-151 formyl peptide receptor 1 Homo sapiens 90-94 3281588-1 1988 Previous studies from our laboratories showed that 5"-p-fluorosulfonylbenzoyl adenosine (FSBA) inhibits ADP-induced platelet shape change, aggregation, and exposure of fibrinogen sites while covalently binding to 100-kDa platelet membrane protein (aggregin) on the intact platelet. Adenosine Diphosphate 104-107 fibrinogen beta chain Homo sapiens 168-178 2833330-2 1988 The association of fibrinogen with washed human platelets was examined by immunocytochemistry during aggregation induced by adenosine diphosphate (ADP) and during deaggregation. Adenosine Diphosphate 124-145 fibrinogen beta chain Homo sapiens 19-29 2833330-6 1988 In the medium with 2 mmol/L Ca2+, ADP caused extensive aggregation of normal platelets in the presence of fibrinogen (0.4 mg/mL), and gold particles were evident between the adherent platelets and on the platelet surface; when the platelets deaggregated, gold was no longer present on the surface. Adenosine Diphosphate 34-37 fibrinogen beta chain Homo sapiens 106-116 2833330-7 1988 In a medium without added Ca2+, ADP caused extensive aggregation in the presence of fibrinogen, and large numbers of gold particles were on the platelet surface and even more between adherent platelets. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 84-94 2831980-1 1988 Isolated human blood platelets, loaded with the pH-sensitive fluorescence dye 2",7"-bis(carboxyethyl)-5,6-carboxyfluorescein show cytoplasmic alkalinization upon stimulation with thrombin but acidification with ADP stimulation. Adenosine Diphosphate 211-214 coagulation factor II, thrombin Homo sapiens 179-187 3346230-4 1988 Platelet stimulation with agonists including thrombin, phorbol myristrate acetate, and ADP increased the extent of cross-linking by predominantly enhancing the coupling of the RGD peptides to the GPIIIa subunit. Adenosine Diphosphate 87-90 integrin subunit beta 3 Homo sapiens 196-202 3334894-1 1988 Fibrinogen is a cofactor in the aggregation of human platelets, and is required for ADP-induced aggregation of washed platelets; however, exogenous fibrinogen is not required for ADP-induced aggregation of washed platelets from rabbits or rats. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 0-10 3131319-13 1988 (1987) in The 8th International Symposium on ADP-Ribosylation, Texas, abstract p. 13), bradykinin functioning in the contraction of smooth muscle may be modified in this way in vivo. Adenosine Diphosphate 45-48 kininogen 1 Homo sapiens 87-97 2827786-0 1988 Fibrin protofibril and fibrinogen binding to ADP-stimulated platelets: evidence for a common mechanism. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 23-33 2827786-3 1988 Fibrin protofibrils bound to ADP-activated platelets in a time- and concentration-dependent process which was effectively blocked by excess unlabelled fibrinogen, i.e., the binding was specific and appeared to involve a common receptor. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 151-161 2827787-1 1988 The molecular basis of platelet-fibrin interactions has been investigated by using synthetic peptides as potential inhibitors of fibrin protofibril and fibrinogen binding to ADP-stimulated platelets, adhesion of fibrin fibers to the platelet surface, and platelet-mediated clot retraction. Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 152-162 2827787-2 1988 Synthetic peptides of sequence RGDS and HHLGGAKQAGDV, corresponding to regions of the fibrinogen alpha- and gamma-chains previously identified as platelet recognition sites, inhibited the binding of radiolabelled soluble fibrin oligomers to ADP-stimulated platelets with IC50 values of 10 and 40 microM, respectively. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 86-96 3245387-4 1988 The stimulatory effect of mitochondria on glycolysis was associated with the decrease of adenylate energy charge which was caused by an apparently very fast production of ADP in the hexokinase reaction. Adenosine Diphosphate 171-174 hexokinase 1 Homo sapiens 182-192 3245387-6 1988 It is therefore suggested that the stimulatory effect of epithelioma mitochondria on glycolysis can be explained by production of ADP by the hexokinase associated with these mitochondria. Adenosine Diphosphate 130-133 hexokinase 1 Homo sapiens 141-151 3386335-3 1988 Triflusal and HTB, at concentrations lower than 1 mM, produced a significant inhibition of platelet aggregation induced by ADP (2.5 microM, final) and collagen (1 microgram/ml, final) in PRP, while about 50% inhibition was induced in WB samples at 0.12 mM. Adenosine Diphosphate 123-126 prion protein Homo sapiens 187-190 3346205-5 1988 When ADP and Pi were added to the thylakoid suspension after a train of flashes [similar to the traditional post-illumination phosphorylation protocol (termed PIP- here)], the post-illumination ATP yield was influenced by pyridine as expected, in a manner consistent with the ATP formation, in part, being driven by protons present in the bulk inner aqueous phase, i.e., through a delocalized protonmotive force. Adenosine Diphosphate 5-8 prolactin induced protein Homo sapiens 159-162 3248113-1 1988 We investigated triglycerides, total cholesterol, HDL cholesterol, the fatty acid patterns of serum triglycerides, cholesterol esters and phospholipids in relation to the ADP induced platelet aggregation in 34 long-term insulin-dependent diabetic patients with an extremely long diabetes duration of about 40 years. Adenosine Diphosphate 171-174 insulin Homo sapiens 220-227 3334894-2 1988 Because with human platelets the cell adhesion peptide, Arg-Gly-Asp-Ser (RGDS), inhibits aggregation and the binding of 125I-fibrinogen to ADP-stimulated platelets, its effects on rabbit and rat platelets were studied to investigate the differences in the fibrinogen requirements of platelets from the three species. Adenosine Diphosphate 139-142 fibrinogen beta chain Homo sapiens 125-135 3334894-4 1988 RGDS inhibited the binding of 125I-fibrinogen to ADP-stimulated human platelets by 80% to 90%, but by only 15% to 27% in the case of rabbit or rat platelets. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 35-45 3366651-4 1988 Next, exogenous and endogenous hexokinase catalyses the reaction between ATP and D-glucose to yield D-glucose-6-phosphate and ADP. Adenosine Diphosphate 126-129 hexokinase 1 Homo sapiens 31-41 3129344-0 1988 Reconstituted microsomal lipid peroxidation: ADP-Fe3+-dependent peroxidation of phospholipid vesicles containing NADPH-cytochrome P450 reductase and cytochrome P450. Adenosine Diphosphate 45-48 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 119-134 2826882-27 1988 In FMLP stimulated neutrophils, the presence of ATP or ADP leads to enhanced increases in intracellular levels of Ca++ as determined by the fura-2 probe, while the presence of AMP or adenosine results in inhibition of the increases in FMLP induced elevations in cytosolic Ca++. Adenosine Diphosphate 55-58 formyl peptide receptor 1 Homo sapiens 3-7 2826882-27 1988 In FMLP stimulated neutrophils, the presence of ATP or ADP leads to enhanced increases in intracellular levels of Ca++ as determined by the fura-2 probe, while the presence of AMP or adenosine results in inhibition of the increases in FMLP induced elevations in cytosolic Ca++. Adenosine Diphosphate 55-58 formyl peptide receptor 1 Homo sapiens 235-239 2450411-4 1988 Platelet aggregation responses in PRP to low doses of ADP (0.5 and 1.0 microM) were significantly increased up to 1 year post-transplantation (p less than 0.02-less than 0.002). Adenosine Diphosphate 54-57 complement component 4 binding protein alpha Homo sapiens 34-37 2842568-3 1988 While ANP alone (1 pM-100 nM) had no effect, ANP significantly potentiated thrombin (0.4 units/ml)-, epinephrine (15 microM)- and ADP (2 or 10 microM)-induced aggregation. Adenosine Diphosphate 130-133 natriuretic peptide A Homo sapiens 45-48 3139948-2 1988 t-PA suppressed adenosine 5"-diphosphate (ADP)- or collagen-induced platelet aggregation in a dose-dependent manner. Adenosine Diphosphate 16-40 plasminogen activator, tissue type Homo sapiens 0-4 3139948-2 1988 t-PA suppressed adenosine 5"-diphosphate (ADP)- or collagen-induced platelet aggregation in a dose-dependent manner. Adenosine Diphosphate 42-45 plasminogen activator, tissue type Homo sapiens 0-4 3319615-11 1987 From this it appears that the pair of linked enzymes comprise a functional compartment supported by propinquity in which hexokinase has preferential access to ATP produced by creatine kinase, and creatine kinase to ADP from the hexokinase reaction. Adenosine Diphosphate 215-218 hexokinase 1 Homo sapiens 121-131 3319615-11 1987 From this it appears that the pair of linked enzymes comprise a functional compartment supported by propinquity in which hexokinase has preferential access to ATP produced by creatine kinase, and creatine kinase to ADP from the hexokinase reaction. Adenosine Diphosphate 215-218 hexokinase 1 Homo sapiens 228-238 2822171-8 1987 Ristocetin-induced binding of vWf was inhibited by 6D1, and ADP-induced binding of fibrinogen was inhibited by LJ-CP8. Adenosine Diphosphate 60-63 fibrinogen beta chain Homo sapiens 83-93 3119586-9 1987 Differences between thrombin- and ADP-evoked influx were further demonstrated by the inhibitory actions of cAMP, which reduced and substantially increased the delay in onset of thrombin-evoked influx but did not measurably delay the influx evoked by an optimal concentration of ADP. Adenosine Diphosphate 34-37 coagulation factor II, thrombin Homo sapiens 177-185 3119586-9 1987 Differences between thrombin- and ADP-evoked influx were further demonstrated by the inhibitory actions of cAMP, which reduced and substantially increased the delay in onset of thrombin-evoked influx but did not measurably delay the influx evoked by an optimal concentration of ADP. Adenosine Diphosphate 278-281 coagulation factor II, thrombin Homo sapiens 177-185 3127924-2 1987 Besides a complete suppression of the ADP-induced aggregation, the two drugs significantly inhibited aggregation and secretion induced by three protein kinase C activators (1-oleoyl-2-acetyl-sn-glycerol, OAG; 12-0-tetradecanoyl phorbol-13-acetate, TPA; phospholipase C), by the calcium ionophore A 23187 and by thrombin. Adenosine Diphosphate 38-41 coagulation factor II Rattus norvegicus 311-319 2822169-1 1987 We used immunoelectron microscopic localization techniques to investigate whether platelets stimulated by ADP or ristocetin in the plasma milieu bind von Willebrand factor (vWF) to their surfaces. Adenosine Diphosphate 106-109 von Willebrand factor Homo sapiens 150-171 2822169-1 1987 We used immunoelectron microscopic localization techniques to investigate whether platelets stimulated by ADP or ristocetin in the plasma milieu bind von Willebrand factor (vWF) to their surfaces. Adenosine Diphosphate 106-109 von Willebrand factor Homo sapiens 173-176 2822169-2 1987 We found by both peroxidase- and ferritin-based methods that unstimulated platelets lack vWF on their surfaces, whereas platelets that are stimulated with ADP or ristocetin have vWF associated with their surfaces. Adenosine Diphosphate 155-158 von Willebrand factor Homo sapiens 178-181 2822171-10 1987 Aspirin and prostaglandin E1 also inhibited ADP-induced binding of vWf in platelet-rich plasma. Adenosine Diphosphate 44-47 von Willebrand factor Homo sapiens 67-70 2822169-5 1987 Thus, in the plasma environment, in the presence of fibrinogen, vWF becomes associated with the platelet surface subsequent to stimulation with ADP or ristocetin. Adenosine Diphosphate 144-147 fibrinogen beta chain Homo sapiens 52-62 2825631-3 1987 Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl4 to a free-radical species identified as trichloromethyl free radical (CCl3) by e.s.r. Adenosine Diphosphate 86-89 C-C motif chemokine ligand 4 Rattus norvegicus 118-122 2822169-5 1987 Thus, in the plasma environment, in the presence of fibrinogen, vWF becomes associated with the platelet surface subsequent to stimulation with ADP or ristocetin. Adenosine Diphosphate 144-147 von Willebrand factor Homo sapiens 64-67 2822171-0 1987 von Willebrand factor is present on the surface of platelets stimulated in plasma by ADP. Adenosine Diphosphate 85-88 von Willebrand factor Homo sapiens 0-21 2822171-4 1987 Using this assay, we found vWf on the surface of platelets stimulated in plasma by ADP. Adenosine Diphosphate 83-86 von Willebrand factor Homo sapiens 27-30 2822171-5 1987 The number of platelets that bound vWf increased in proportion to ADP concentration and incubation time. Adenosine Diphosphate 66-69 von Willebrand factor Homo sapiens 35-38 2822171-6 1987 Washed platelets in a protein-free buffer activated by 1 mumol/L calcium ionophore A23187 or 10 mumol/L ADP also bound vWf, suggesting that we were detecting surface binding of alpha-granule-derived vWf. Adenosine Diphosphate 104-107 von Willebrand factor Homo sapiens 119-122 2822171-6 1987 Washed platelets in a protein-free buffer activated by 1 mumol/L calcium ionophore A23187 or 10 mumol/L ADP also bound vWf, suggesting that we were detecting surface binding of alpha-granule-derived vWf. Adenosine Diphosphate 104-107 von Willebrand factor Homo sapiens 199-202 3667696-5 1987 When platelets were stimulated with ADP 10-20 s after addition of PR to a final pH of 6 (PR6), both myosin light chain (MLC) phosphorylation and myosin and actin association with the cytoskeleton were reduced in correlation with the inhibition of shape change. Adenosine Diphosphate 36-39 modulator of VRAC current 1 Homo sapiens 100-118 3667696-5 1987 When platelets were stimulated with ADP 10-20 s after addition of PR to a final pH of 6 (PR6), both myosin light chain (MLC) phosphorylation and myosin and actin association with the cytoskeleton were reduced in correlation with the inhibition of shape change. Adenosine Diphosphate 36-39 modulator of VRAC current 1 Homo sapiens 120-123 3667696-6 1987 But when ADP was added 30 s after PR6, the MLC phosphorylation was essentially the same in PR or in chloride, although shape change and myosin and actin association with the cytoskeleton remained inhibited. Adenosine Diphosphate 9-12 modulator of VRAC current 1 Homo sapiens 43-46 3497679-0 1987 Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. Adenosine Diphosphate 106-109 fibrinogen beta chain Homo sapiens 54-64 3497679-0 1987 Effect of calcium ion concentration on the ability of fibrinogen and von Willebrand factor to support the ADP-induced aggregation of human platelets. Adenosine Diphosphate 106-109 von Willebrand factor Homo sapiens 69-90 3497679-3 1987 In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Adenosine Diphosphate 98-101 von Willebrand factor Homo sapiens 34-37 3497679-3 1987 In the low calcium medium, either vWf or fibrinogen supported biphasic aggregation in response to ADP, with thromboxane formation and release of granule contents. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 41-51 3497679-6 1987 Although vWf supports ADP-induced aggregation when the concentration of ionized calcium is in the micromolar range, it does not support ADP-induced aggregation in the presence of a concentration of ionized calcium in the physiological range, indicating that vWf probably cannot substitute for fibrinogen in supporting ADP-induced aggregation in vivo. Adenosine Diphosphate 22-25 von Willebrand factor Homo sapiens 9-12 3620698-6 1987 Platelets were aggregated with adenosine diphosphate (ADP) in the presence of fibrinogen, agglutinated with polylysine, or after pretreatment with chymotrypsin, aggregated with fibrinogen. Adenosine Diphosphate 54-57 fibrinogen beta chain Homo sapiens 78-88 3607287-0 1987 ADP-induced platelet aggregation depends on the conformation or availability of the terminal gamma chain sequence of fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 117-127 3677678-6 1987 The aggregation to thrombin was mostly related to lanosterol biosynthesis and the aggregation to ADP to platelet cholesterol, but not to plasma lipids or apoproteins. Adenosine Diphosphate 97-100 coagulation factor II, thrombin Homo sapiens 19-27 2442198-1 1987 The chromatin-bound enzyme poly(ADP-ribose) polymerase (ADPRP) is strongly stimulated by DNA with single- or double-stranded breaks, and transfers the ADP-ribose moiety of NAD to nuclear proteins. Adenosine Diphosphate 32-35 poly(ADP-ribose) polymerase 1 Homo sapiens 56-61 3611085-6 1987 Protection of calcineurin by ADP was enhanced severalfold by calmodulin, which correlated well with a calmodulin-stimulated decrease in the Ki for this ligand. Adenosine Diphosphate 29-32 calmodulin 1 Homo sapiens 61-71 3611085-6 1987 Protection of calcineurin by ADP was enhanced severalfold by calmodulin, which correlated well with a calmodulin-stimulated decrease in the Ki for this ligand. Adenosine Diphosphate 29-32 calmodulin 1 Homo sapiens 102-112 3607284-5 1987 The increased binding of LJ-CP3, but not of the other two antibodies, to activated platelets decreased by 30% to 40% in the presence of EDTA at 22 to 25 degrees C. Platelets stimulated by thrombin or PMA bound more fibrinogen than did those stimulated by ADP, and significant differences in the extent but not in the affinity of fibrinogen binding were observed with various platelet agonists. Adenosine Diphosphate 255-258 coagulation factor II, thrombin Homo sapiens 188-196 3607287-4 1987 Aggregation of ADP-stimulated normal platelets was defective with fibrinogen Paris I and markedly depressed with the gamma Paris I chain. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 66-76 3607284-6 1987 When the pool of GP IIb/IIIa molecules exposed on the surface of unstimulated platelets was reacted with the monoclonal antibody LJ-CP3 to block ADP-induced fibrinogen binding and platelet aggregation, stimulation with thrombin or PMA still induced substantial binding of antibody and fibrinogen, and aggregation ensued. Adenosine Diphosphate 145-148 fibrinogen beta chain Homo sapiens 157-167 3607287-9 1987 These observations demonstrate that the gamma chain platelet recognition site in the fibrinogen molecule is necessary but not alone sufficient to support normal ADP-induced platelet aggregation. Adenosine Diphosphate 161-164 fibrinogen beta chain Homo sapiens 85-95 3108259-2 1987 Moreover, ML-9 as well as ATP or ADP exhibited an effective protection to inactivation of smooth muscle myosin light chain kinase by the nucleotide affinity label 5"-p-fluorosulfonylbenzoyladenosine, suggesting that ML-9 binds at or near the ATP-binding site on the kinase molecule. Adenosine Diphosphate 33-36 myosin light chain kinase, smooth muscle Oryctolagus cuniculus 90-129 3597408-7 1987 Increases in the sensitivity of cytosolic respiratory control resulted in lower flux through the near-equilibrium energy exchange reactions of creatine kinase and myokinase such that calculated free concentrations of ADP and AMP were less. Adenosine Diphosphate 217-220 adenylate kinase 1 Rattus norvegicus 163-172 3629559-1 1987 The CNBr-split N-terminal disulphide knot of the fibrinogen molecule (N-DSK) binds to ADP-stimulated gel-filtered platelets and immunoprecipitated fibrinogen receptor. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 49-59 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 fibrinogen beta chain Homo sapiens 206-216 3591957-1 1987 Purine nucleotides, particularly adenosine diphosphate (ADP), are the most potent mitogens known for monkey kidney epithelial cells of the BSC-1 line. Adenosine Diphosphate 33-54 solute carrier family 12 member 1 Homo sapiens 139-144 3591957-1 1987 Purine nucleotides, particularly adenosine diphosphate (ADP), are the most potent mitogens known for monkey kidney epithelial cells of the BSC-1 line. Adenosine Diphosphate 56-59 solute carrier family 12 member 1 Homo sapiens 139-144 3591957-7 1987 As with ADP-stimulated expression of the c-ras protooncogene, transcripts of the transferrin receptor gene reached a maximal value at 12 h, whereas the abundance of gamma-actin mRNA was not altered for up to 24 h. The results indicate that exogenous ADP stimulates protooncogene expression before initiation of DNA synthesis in renal epithelial cells in culture. Adenosine Diphosphate 8-11 transferrin Homo sapiens 81-92 3591957-7 1987 As with ADP-stimulated expression of the c-ras protooncogene, transcripts of the transferrin receptor gene reached a maximal value at 12 h, whereas the abundance of gamma-actin mRNA was not altered for up to 24 h. The results indicate that exogenous ADP stimulates protooncogene expression before initiation of DNA synthesis in renal epithelial cells in culture. Adenosine Diphosphate 250-253 transferrin Homo sapiens 81-92 2438305-2 1987 When added to a suspension of human platelets induced to aggregate in plasma with adenosine 5"-diphosphate, t-PA promoted disaggregation of platelets over several minutes. Adenosine Diphosphate 82-106 plasminogen activator, tissue type Homo sapiens 108-112 3573979-4 1987 Functional responsiveness of the platelet 5-HT2 receptor complex was assessed by measurement of the extent to which serotonin (10uM) augmented platelet aggregation induced by threshold concentrations of adenosine diphosphate (ADP). Adenosine Diphosphate 226-229 5-hydroxytryptamine receptor 2A Homo sapiens 42-56 3616571-10 1987 These studies suggest that epinephrine- and ADP-induced platelet aggregation occurs via the exposure of fibrinogen receptors on shape-changed platelets. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 104-114 3629541-5 1987 Pretreatment of the PRP with epinephrine increased the maximum transmittance during ADP aggregation, produced less-reversible aggregates (less subject to deaggregation by PGE1), and increased the aggregate flow resistance over the range of filtration pressures tested. Adenosine Diphosphate 84-87 complement component 4 binding protein alpha Homo sapiens 20-23 3573979-4 1987 Functional responsiveness of the platelet 5-HT2 receptor complex was assessed by measurement of the extent to which serotonin (10uM) augmented platelet aggregation induced by threshold concentrations of adenosine diphosphate (ADP). Adenosine Diphosphate 203-224 5-hydroxytryptamine receptor 2A Homo sapiens 42-56 3606733-2 1987 This hypersensitivity to thrombin persisted in the presence of CP/CPK to convert released ADP to ATP, and aspirin to block formation of thromboxane A2. Adenosine Diphosphate 90-93 coagulation factor II Rattus norvegicus 25-33 3805272-2 1987 Thrombin, collagen, and Ca2+-ionophore A23187 aggregate platelets in the presence of inhibitors of the first (ADP-mediated) and second (cyclooxygenase-dependent) pathway of platelet activation. Adenosine Diphosphate 110-113 coagulation factor II, thrombin Homo sapiens 0-8 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Adenosine Diphosphate 49-70 fibrinogen beta chain Homo sapiens 14-24 3035741-2 1987 The amount of fibrinogen bound by stimulation of adenosine diphosphate (ADP) and 5-hydroxytryptamine (5HT) increased in a dose-dependent manner. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 14-24 3035741-4 1987 Fibrinogen could bind to platelets in response to ADP, regardless of whether they were desensitized by 5HT, and vice versa. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 0-10 3558491-4 1987 The inhibitory activity was detectable in the supernatants of platelet suspensions aggregated by thrombin or ADP, and the inhibitory activity released from ADP-stimulated platelets was blocked by pretreatment of platelets with monoclonal antibody HuPl-m1. Adenosine Diphosphate 156-159 coagulation factor II, thrombin Homo sapiens 97-105 2974916-8 1987 A twofold displacement of particulate hexokinase by ATP, ADP, 1-O-methylglucose, sorbitol-6-phosphate, and dibutyryl cyclic AMP was observed in the high-grade glioma-derived lines. Adenosine Diphosphate 57-60 hexokinase 1 Homo sapiens 38-48 2953085-0 1987 V1a-vasopressin specific receptors on human platelets: potentiation by ADP and epinephrine and evidence for homologous down-regulation. Adenosine Diphosphate 71-74 arginine vasopressin Homo sapiens 4-15 2953085-3 1987 Aggregating effect of VP on human platelets was potentiated by both ADP and epinephrine. Adenosine Diphosphate 68-71 arginine vasopressin Homo sapiens 22-24 2437231-6 1987 As-VWF binding to the GPllb-llla complex appears to be approximately 70% to 80% ADP dependent and approximately 20% to 30% ADP independent. Adenosine Diphosphate 80-83 von Willebrand factor Homo sapiens 3-6 2437231-6 1987 As-VWF binding to the GPllb-llla complex appears to be approximately 70% to 80% ADP dependent and approximately 20% to 30% ADP independent. Adenosine Diphosphate 123-126 von Willebrand factor Homo sapiens 3-6 3603436-2 1987 Fibrinogen binding sites were exposed by stimulating platelets with ADP or with chymotrypsin. Adenosine Diphosphate 68-71 fibrinogen beta chain Homo sapiens 0-10 3603436-4 1987 The Km values for fibrinogen mediated aggregation of ADP-stimulated platelets obtained from control and diabetic donors were 1.39 +/- 0.13 X 10(-7)M and 1.44 +/- 0.13 X 10(-7)M; the Vmax values (expressed in arbitrary light transmission units) were 87.8 +/- 3.14 and 92.8 +/- 4.5 (mean +/- S.E.M.). Adenosine Diphosphate 53-56 fibrinogen beta chain Homo sapiens 18-28 3033838-1 1987 Recent evidence indicates that adrenaline and adenosine diphosphate each have separate stimulus-response pathways for induction of aggregation and inhibition of cAMP accumulation. Adenosine Diphosphate 46-67 cathelicidin antimicrobial peptide Homo sapiens 161-165 3033838-3 1987 Our studies showed that the inhibitory effect of adrenaline and adenosine diphosphate on PGE1-induced increase of cAMP in the patients was not different from that of the controls both for adrenaline and adenosine diphosphate. Adenosine Diphosphate 64-85 cathelicidin antimicrobial peptide Homo sapiens 114-118 3036080-8 1987 Addition of ADP-consuming enzymes decreased sensitivity to thrombin, but inhibition of cyclo-oxygenase with indomethacin did not impair the thrombin-induced hydrolysis of phosphoinositides. Adenosine Diphosphate 12-15 coagulation factor II, thrombin Homo sapiens 59-67 3805054-6 1987 Here we report the effect of pH and ADP on the dissociation of the membranous form of dopamine beta-hydroxylase into two nonidentical subunits. Adenosine Diphosphate 36-39 dopamine beta-hydroxylase Bos taurus 86-111 3827975-5 1987 The specificity of the beta 2-G-I interaction with the ADP-activation is supported by results obtained with collagen or thrombin as aggregating agents. Adenosine Diphosphate 55-58 coagulation factor II, thrombin Homo sapiens 120-128 3804319-4 1987 There are two receptor pathways--classic and alternative--for the binding of vWF to platelets; the latter induced by thrombin, and adenosine diphosphate (ADP) is shared with fibrinogen. Adenosine Diphosphate 131-152 von Willebrand factor Homo sapiens 77-80 3804319-4 1987 There are two receptor pathways--classic and alternative--for the binding of vWF to platelets; the latter induced by thrombin, and adenosine diphosphate (ADP) is shared with fibrinogen. Adenosine Diphosphate 154-157 von Willebrand factor Homo sapiens 77-80 3554158-8 1987 Dilation of coronary arteries after intracoronary administration of SIN-1, with inhibition of platelet aggregation by restrained release of adenosine diphosphate and stabilization of platelet membranes, facilitates the recanalization of stenosed arteries and reduces coronary muscle tone at the site of thrombosis. Adenosine Diphosphate 140-161 MAPK associated protein 1 Homo sapiens 68-73 2827552-3 1987 At least one receptor mechanism for fibrinogen and for vWF is controlled by ADP that is secreted through the known pathways of platelet activation and counterbalanced by cyclic AMP. Adenosine Diphosphate 76-79 fibrinogen beta chain Homo sapiens 36-46 2827552-3 1987 At least one receptor mechanism for fibrinogen and for vWF is controlled by ADP that is secreted through the known pathways of platelet activation and counterbalanced by cyclic AMP. Adenosine Diphosphate 76-79 von Willebrand factor Homo sapiens 55-58 3503504-8 1987 IAP ADP-ribosylated 41,000 dalton proteins at each stage and the specific activity of ADP-ribosylation was not changed during development and aging. Adenosine Diphosphate 4-7 alkaline phosphatase, intestinal Homo sapiens 0-3 3023367-11 1986 Thrombin-induced diacylglycerol formation and 45Ca release were also inhibited when the saponin-treated platelets were preincubated with pertussis toxin, an event that was associated with the ADP-ribosylation of a protein with Mr = 41.7 kDa. Adenosine Diphosphate 192-195 coagulation factor II, thrombin Homo sapiens 0-8 3810563-3 1986 All fragments tested except for E derived from fibrinogen (Efg) and Degta bound specifically to the platelets and inhibited ADP-induced aggregation in the presence of fibrinogen. Adenosine Diphosphate 124-127 fibrinogen beta chain Homo sapiens 47-57 3101672-11 1986 The amounts of thromboxane A2 and secreted ADP, however, are sufficient for initiating high- and low-affinity fibrinogen binding via mutually independent mechanisms. Adenosine Diphosphate 43-46 fibrinogen beta chain Homo sapiens 110-120 3814578-1 1986 The decarboxylation of oxalacetate by pyruvate carboxylase in the absence of ADP and Pi is stimulated 400-fold by the presence of oxamate, which is an inhibitory analogue of pyruvate. Adenosine Diphosphate 77-80 pyruvate carboxylase Homo sapiens 38-58 3800991-1 1986 Ajoene, the major antiplatelet compound derived from garlic inhibits the fibrinogen-supported aggregation of washed human platelets (ID50 = 13 microM) and, inhibits binding of 125I-fibrinogen to ADP-stimulated platelets (ID50 = 0.8 microM). Adenosine Diphosphate 195-198 fibrinogen beta chain Homo sapiens 181-191 3097315-5 1986 Benzopyranone 3 is of interest since it was the most potent inhibitor of thrombin-induced [3H]AA release (3 much greater than 4 = 1) and more potent than 1 or 4 for the blockade of the ADP- or AA-mediated pathway of platelet aggregation. Adenosine Diphosphate 185-188 coagulation factor II, thrombin Homo sapiens 73-81 3760194-2 1986 After stimulation with ADP (10 microM) or thrombin (1 U/ml), platelet-free suspensions of human monocytes bind 125I-fibrinogen with two different affinities in a specific and Ca2+-dependent reaction with saturation at 5.80-7.35 X 10(-7) M of added protein. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 116-126 3772222-4 1986 ATP, as well as adenosine diphosphate and 2,3-diphosphoglyceric acid, interacts synergistically with the ammonium sulfate hemolysate fraction to promote iron release from transferrin. Adenosine Diphosphate 16-37 transferrin Homo sapiens 171-182 3772299-1 1986 Human monocytes potentiate the ADP-stimulated aggregation of autologous platelets through a fourfold increased binding of 125I-fibrinogen to the platelet surface. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 127-137 2948294-3 1986 The second wave of aggregation of human PRP induced by epinephrine and platelet activating factor (PAF) was abolished by similar concentrations of the TXA2/PGH2 antagonists, whereas aggregation of canine PRP induced by ADP, serotonin plus epinephrine, or PAF was unaffected by these concentrations of the TXA2/PGH2 antagonists. Adenosine Diphosphate 219-222 complement component 4 binding protein alpha Homo sapiens 40-43 2948294-3 1986 The second wave of aggregation of human PRP induced by epinephrine and platelet activating factor (PAF) was abolished by similar concentrations of the TXA2/PGH2 antagonists, whereas aggregation of canine PRP induced by ADP, serotonin plus epinephrine, or PAF was unaffected by these concentrations of the TXA2/PGH2 antagonists. Adenosine Diphosphate 219-222 complement component 4 binding protein alpha Homo sapiens 204-207 3007520-4 1986 The uvsX protein purified from cells with a uvsX+ plasmid catalyzes ATP hydrolysis to ADP and AMP and, in the presence of the T4 gene 32 helix-destablizing protein, ATP-dependent strand exchange between homologous circular single-stranded and linear duplex DNA. Adenosine Diphosphate 86-89 recombinase RecA Escherichia phage T4 4-8 3091591-4 1986 The fMLP-stimulated formation of the phosphorylated inositols was markedly reduced by the prior ADP-ribosylation of the membranes with pertussis toxin. Adenosine Diphosphate 96-99 formyl peptide receptor 1 Homo sapiens 4-8 3091591-6 1986 Reconstitution of the membranes ADP-ribosylated by pertussis toxin with Gi or Go purified from rat brain restored the fMLP-stimulated formation of the phosphorylated inositols. Adenosine Diphosphate 32-35 formyl peptide receptor 1 Homo sapiens 118-122 3015284-3 1986 Complete inhibition of ADP-induced aggregation was achieved five minutes after platelet exposure to 0.10 to 0.25 mmol/L of DB when fibrinogen binding was reduced by 50%. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 131-141 3015284-4 1986 At higher concentrations of DB (approximately 1 mmol/L), ADP-induced fibrinogen binding was completely blocked. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 69-79 3026316-7 1986 Increases in the labelling of phosphatidic acid at 10 s and of inositol bisphosphate and inositol phosphate after 20 s are consistent with phospholipase C being stimulated through some other mechanism that leads to the degradation of PIP and phosphatidylinositol; one possibility is that ADP causes an increase in cytoplasmic Ca2+. Adenosine Diphosphate 288-291 LOC100009319 Oryctolagus cuniculus 139-154 2944882-11 1986 E-P formed with A1b + B complex was ADP-sensitive (E1-P), and was not further decomposed, since the transition from E1-P to E2-P was blocked. Adenosine Diphosphate 36-39 syntrophin beta 1 Homo sapiens 16-19 3088445-1 1986 ADP-ribosyl transferase (ADPRT) is a DNA-dependent chromatin-associated enzyme which covalently attaches ADP-ribose moieties derived from NAD+ to protein acceptors to form poly(ADP-ribose). Adenosine Diphosphate 0-3 poly(ADP-ribose) polymerase 1 Homo sapiens 25-30 3721088-1 1986 ADP-induced platelet aggregation was measured in 15 Type 1 (insulin-dependent) diabetic patients, 15 Type 2 (non-insulin-dependent) diabetic patients and in 15 non-diabetic control subjects. Adenosine Diphosphate 0-3 insulin Homo sapiens 60-67 3018111-2 1986 Correction by arachidonic acid of the impaired exposure of fibrinogen receptors by adenosine diphosphate or collagen. Adenosine Diphosphate 83-104 fibrinogen beta chain Homo sapiens 59-69 3018111-8 1986 Therefore, we investigated the binding of iodine 125-labeled fibrinogen to uremic platelets exposed to ADP, collagen, or arachidonic acid as single agents and as pairs. Adenosine Diphosphate 103-106 fibrinogen beta chain Homo sapiens 61-71 3018111-9 1986 When aggregation and binding were studied in response to ADP, collagen, or the combination of ADP with collagen, uremic platelets had reduced aggregation and bound abnormally low amounts of fibrinogen. Adenosine Diphosphate 94-97 fibrinogen beta chain Homo sapiens 190-200 3018111-10 1986 In contrast, platelets from patients with uremia bound as much 125I-fibrinogen and aggregated as well as controls when ADP or collagen were used in combination with low concentrations of arachidonic acid. Adenosine Diphosphate 119-122 fibrinogen beta chain Homo sapiens 68-78 3018111-12 1986 We conclude that uremia impairs the exposure of fibrinogen receptors on platelets in response to ADP or collagen without affecting the glycoprotein IIb-IIa complex quantitatively. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 48-58 3018111-13 1986 Correction by arachidonic acid of the impaired aggregation and exposure of fibrinogen receptors by ADP or collagen suggests that abnormal release of endogenous arachidonic acid plays a role in the dysfunction of platelets in uremia. Adenosine Diphosphate 99-102 fibrinogen beta chain Homo sapiens 75-85 3013859-2 1986 The present studies demonstrate that epinephrine and ADP stimulate a phosphatidylinositol-hydrolyzing phospholipase A2 activity in human platelets. Adenosine Diphosphate 53-56 phospholipase A2 group IB Homo sapiens 102-118 2942107-3 1986 For both PFK homologs, carbethoxylation reduces the sensitivity to ATP and citrate inhibition, the cooperativity as a function of fructose 6-phosphate concentration and the degree of activation in the presence ADP, AMP, and fructose 2,6-bisphosphate. Adenosine Diphosphate 210-213 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 9-12 3711102-0 1986 Adenosine 5"-diphosphate-dependent subunit dissociation of bovine dopamine beta-hydroxylase. Adenosine Diphosphate 0-24 dopamine beta-hydroxylase Bos taurus 66-91 3711102-6 1986 Quantitative binding of ADP to dopamine beta-hydroxylase revealed that there are two binding sites/dimeric species of hydroxylase and that ADP is tightly bound with a KD less than 10(-8) M. Kinetic data obtained at pH 5.5, the pH inside the chromaffin granule, shows that the apparent Km values for both the substrates tyramine and ascorbate are lowered by the presence of ADP without affecting the Vmax of the enzyme. Adenosine Diphosphate 24-27 dopamine beta-hydroxylase Bos taurus 31-56 3711102-6 1986 Quantitative binding of ADP to dopamine beta-hydroxylase revealed that there are two binding sites/dimeric species of hydroxylase and that ADP is tightly bound with a KD less than 10(-8) M. Kinetic data obtained at pH 5.5, the pH inside the chromaffin granule, shows that the apparent Km values for both the substrates tyramine and ascorbate are lowered by the presence of ADP without affecting the Vmax of the enzyme. Adenosine Diphosphate 139-142 dopamine beta-hydroxylase Bos taurus 31-56 3711102-6 1986 Quantitative binding of ADP to dopamine beta-hydroxylase revealed that there are two binding sites/dimeric species of hydroxylase and that ADP is tightly bound with a KD less than 10(-8) M. Kinetic data obtained at pH 5.5, the pH inside the chromaffin granule, shows that the apparent Km values for both the substrates tyramine and ascorbate are lowered by the presence of ADP without affecting the Vmax of the enzyme. Adenosine Diphosphate 139-142 dopamine beta-hydroxylase Bos taurus 31-56 3715810-3 1986 Both heparins caused significant enhancement of a low concentration of ADP-induced activation of PRP and, again, the effect of LMWH was somewhat less than that of UFH. Adenosine Diphosphate 71-74 prion protein Homo sapiens 97-100 3012818-4 1986 Established ADP-induced aggregation was reversed by bimane, and fibrinogen binding to ADP-stimulated platelets was inhibited, an effect mainly due to decreased number of binding sites. Adenosine Diphosphate 12-15 fibrinogen beta chain Homo sapiens 64-74 3012818-4 1986 Established ADP-induced aggregation was reversed by bimane, and fibrinogen binding to ADP-stimulated platelets was inhibited, an effect mainly due to decreased number of binding sites. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 64-74 3699150-4 1986 Histones Hl and H2B were the best ADP-ribose acceptors. Adenosine Diphosphate 34-37 histone cluster 1, H2bg Rattus norvegicus 16-19 3007520-4 1986 The uvsX protein purified from cells with a uvsX+ plasmid catalyzes ATP hydrolysis to ADP and AMP and, in the presence of the T4 gene 32 helix-destablizing protein, ATP-dependent strand exchange between homologous circular single-stranded and linear duplex DNA. Adenosine Diphosphate 86-89 recombinase RecA Escherichia phage T4 44-48 3956735-2 1986 A high rate of ADP-independent (non-coupled with ATP synthesis) respiration is observed during oxidation of succinate, NADH and ascorbate + cytochrome c, but not with NAD-dependent substrates. Adenosine Diphosphate 15-18 cytochrome c, somatic Homo sapiens 140-152 3008579-1 1986 Stimulation of intact platelets by ADP results in a shape change followed by aggregation in the presence of fibrinogen. Adenosine Diphosphate 35-38 fibrinogen beta chain Homo sapiens 108-118 3008579-5 1986 On the other hand, the aggregation of chymotrypsin-treated platelets by fibrinogen was not dependent on the presence of ADP and could not be blocked by forskolin, prostaglandin E1, or prostacyclin, even though the levels of cyclic AMP (cAMP) formed in chymotrypsin-treated platelets were comparable to levels that completely inhibited the ADP-induced aggregation of intact platelets. Adenosine Diphosphate 339-342 fibrinogen beta chain Homo sapiens 72-82 3007578-5 1986 Addition of purified vWF to the afibrinogenemic plasma resulted in marked increase in the rate and extent of aggregation, particularly when platelets were stimulated with ADP. Adenosine Diphosphate 171-174 von Willebrand factor Homo sapiens 21-24 2854747-2 1986 Pertussis toxin catalyzed ADP-ribosylation of Gi alpha in ROS cells increased agonist (PTH and isoproterenol)-stimulated, but not basal, cAMP production. Adenosine Diphosphate 26-29 parathyroid hormone Rattus norvegicus 87-90 3082363-3 1986 Native enzyme showed biphasic kinetics with substrates (glucose and glyceraldehyde), was strongly inhibited by 15 microM ADP, 1,3-diphosphoglycerate, 2,3-diphosphoglycerate and 3-phosphoglycerate, and aldose reductase inhibitors such as sorbinil and alrestatin. Adenosine Diphosphate 121-124 aldo-keto reductase family 1 member B Homo sapiens 201-217 3954674-4 1986 In response to ADP, collagen, or thrombin, FH platelets bound about twice as much 125I-fibrinogen as controls. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 87-97 3954674-7 1986 After stimulation with thrombin or collagen, the hyperaggregable platelets from FH patients were shown to bind significantly more fibrinogen than control platelets even when PG/Tx formation was suppressed (aspirin) and secreted ADP was scavenged (apyrase). Adenosine Diphosphate 228-231 coagulation factor II, thrombin Homo sapiens 23-31 3083530-3 1986 The presence of CRP stimulated ADP-induced activation, whereas CRP has no effect on collagen-induced activation. Adenosine Diphosphate 31-34 C-reactive protein Homo sapiens 16-19 3949008-4 1986 Both EGTA, which abolished the latter and creatine phosphate/creatine phosphokinase, the ADP scavenger, totally inhibited the aggregation but only partially reduced [14C]5HT secretion in response to thrombin plus OAG. Adenosine Diphosphate 89-92 coagulation factor II, thrombin Homo sapiens 199-207 3961734-4 1986 In other experiments ADP (1.0 microM) and epinephrine (2.0 microM) induced typical biphasic aggregation responses in human PRP. Adenosine Diphosphate 21-24 prion protein Homo sapiens 123-126 3012375-3 1986 Platelet rich plasma (PRP) was stimulated with ADP, collagen, sodium arachidonate, PAF, A23187 and epinephrine, while resuspended washed platelets (WP) were stimulated by thrombin. Adenosine Diphosphate 47-50 complement component 4 binding protein alpha Homo sapiens 22-25 2869031-3 1986 The blockade of SRIF"s inhibitory effect on the actions of TRH or VIP was dependent on both the duration of preincubation and concentration of the toxin and was correlated with the ability of the toxin to catalyze the ADP-ribosylation of the 39,000-Da membrane protein. Adenosine Diphosphate 218-221 vasoactive intestinal peptide Rattus norvegicus 66-69 3942829-5 1986 The latter fibrinogen was 50% less effective than F gamma 50 in supporting ADP-induced platelet aggregation at concentrations of .01 to 2 mg/mL. Adenosine Diphosphate 75-78 fibrinogen beta chain Homo sapiens 11-21 3080538-9 1986 Thus, the enhanced platelet aggregation in response to low concentrations of thrombin was likely mediated in part by released ADP and products formed from arachidonate. Adenosine Diphosphate 126-129 coagulation factor II Rattus norvegicus 77-85 3080538-11 1986 Thus, a thrombin-induced pathway(s) of aggregation and release independent of released ADP and the products of arachidonate metabolism is enhanced in platelets from diabetic rats. Adenosine Diphosphate 87-90 coagulation factor II Rattus norvegicus 8-16 3080539-8 1986 Except at low concentrations of thrombin, the enhanced sensitivity to thrombin-induced aggregation and release of granule contents from platelets from diabetic rats or their nondiabetic littermates could not be inhibited by creatine phosphate-creatine phosphokinase (CP/CPK) and aspirin (CP/CPK used at concentrations that inhibited aggregation induced by ADP [10 mumol/L] and aspirin at concentrations that inhibited thromboxane B2 production induced by thrombin [1 U/ml] by 99%). Adenosine Diphosphate 356-359 coagulation factor II Rattus norvegicus 70-78 3080539-8 1986 Except at low concentrations of thrombin, the enhanced sensitivity to thrombin-induced aggregation and release of granule contents from platelets from diabetic rats or their nondiabetic littermates could not be inhibited by creatine phosphate-creatine phosphokinase (CP/CPK) and aspirin (CP/CPK used at concentrations that inhibited aggregation induced by ADP [10 mumol/L] and aspirin at concentrations that inhibited thromboxane B2 production induced by thrombin [1 U/ml] by 99%). Adenosine Diphosphate 356-359 coagulation factor II Rattus norvegicus 70-78 3496699-0 1986 von Willebrand factor can substitute for plasma fibrinogen in ADP-induced platelet aggregation. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 3471057-3 1986 This appears to occur via the Cr-CrP shuttle whereby the ADP produced as a result of contraction is converted to ATP via the adenylate kinase reaction with the production of AMP. Adenosine Diphosphate 57-60 C-reactive protein Homo sapiens 33-36 3029212-1 1986 The potential for iron bound to transferrin to be released and promote the peroxidation of phospholipid liposomes was investigated using ADP as a low molecular weight chelator and superoxide generated by the xanthine/xanthine oxidase system as the reducing agent. Adenosine Diphosphate 137-140 transferrin Homo sapiens 32-43 3010440-3 1986 Fibrinogen Oslo I acted more efficiently in ADP-induced platelet aggregation, and bound to gel-filtered platelets with a higher affinity constant than did normal fibrinogen. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 0-10 3020902-6 1986 These data indicate that dadenosine phosphorylation by adenosine kinase is primarily regulated by its Km, and the concentrations of Mg2+, ADP and AMP. Adenosine Diphosphate 138-141 adenosine kinase Homo sapiens 55-71 3029212-5 1986 Conditions resulting in the most rapid release of iron from transferrin (low pH, high ADP) did not promote the greatest rates of lipid peroxidation, indicating that at neutral pH, rates of lipid peroxidation may be limited by the availability of iron. Adenosine Diphosphate 86-89 transferrin Homo sapiens 60-71 3003956-6 1985 Thrombin produces a much higher cGMP elevation in GFP than ADP or collagen. Adenosine Diphosphate 59-62 coagulation factor II, thrombin Homo sapiens 0-8 3937599-0 1985 Regulation of endogenously catalyzed ADP-ribosylation in adipocyte plasma membranes by Ca2+ and calmodulin. Adenosine Diphosphate 37-40 calmodulin 1 Homo sapiens 96-106 2999129-11 1985 These data indicate that deoxyadenosine phosphorylation by adenosine kinase is primarily regulated by its Km and the concentrations of Mg2+, ADP, and AMP. Adenosine Diphosphate 141-144 adenosine kinase Homo sapiens 59-75 3877935-4 1985 Gly-Arg-Gly-Asp-Ser-Pro was used as a prototype peptide, and this hexapeptide inhibited fibrinogen binding to ADP and thrombin-stimulated platelets in the 10-200 microM range. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 88-98 2867203-5 1985 Pertussis toxin uncouples SRIF receptors from adenylate cyclase by catalyzing the ADP-ribosylation of an inhibitory guanine nucleotide binding protein (Ni) in AtT-20 cell membranes. Adenosine Diphosphate 82-85 somatostatin Mus musculus 26-30 2991399-0 1985 Ca+2 mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation. Adenosine Diphosphate 68-89 fibrinogen beta chain Homo sapiens 22-32 2931566-2 1985 Aggregation of citrated platelet-rich plasma (PRP) from 23 healthy volunteers induced by ADP, adrenaline, arachidonic acid, collagen, gamma-thrombin, the endoperoxide analogue U-44069, serotonin, the calcium ionophore A-23187 or platelet aggregating factor was measured after incubation of PRP with ANF for 3 minutes at concentrations of 4 X 10(-9), 4 X 10(-8) and 4 X 10(-7) M or vehicle as control. Adenosine Diphosphate 89-92 complement component 4 binding protein alpha Homo sapiens 46-49 2931566-3 1985 ANF decreased ADP-induced aggregation significantly (P less than 0.02), but only at the highest concentration used and to a minor extent (control: 73.6 +/- 11.2%; after ANF 4 X 10(-7) M: 60.0 +/- 17.1%, mean +/- S.D., n = 39) by a selective inhibitory effect on the secondary wave; neither aggregation by all other agents tested nor thromboxane B2 generation induced by ADP and adrenaline was altered by incubation with ANF. Adenosine Diphosphate 14-17 natriuretic peptide A Homo sapiens 0-3 2931566-3 1985 ANF decreased ADP-induced aggregation significantly (P less than 0.02), but only at the highest concentration used and to a minor extent (control: 73.6 +/- 11.2%; after ANF 4 X 10(-7) M: 60.0 +/- 17.1%, mean +/- S.D., n = 39) by a selective inhibitory effect on the secondary wave; neither aggregation by all other agents tested nor thromboxane B2 generation induced by ADP and adrenaline was altered by incubation with ANF. Adenosine Diphosphate 370-373 natriuretic peptide A Homo sapiens 0-3 3877250-10 1985 High energy phosphate compounds (ATP, ADP, CTP, and others) displaced mitochondria-bound hexokinase, which increased the cytosolic form by 2-fold in the glioma lines, but fibroblast hexokinase distribution was unaffected. Adenosine Diphosphate 38-41 hexokinase 1 Homo sapiens 89-99 2993278-5 1985 These inhibitors abolished thrombin and ADP-induced fibrinogen binding. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 52-62 2990572-11 1985 Under conditions of our standard experiment ([ADP] = 0.5 mM), adenylate kinase provides about 50% of the ATP used by hexokinase in well-coupled mitochondria. Adenosine Diphosphate 46-49 hexokinase 1 Homo sapiens 117-127 3863817-11 1985 When photolyzed rhodopsin and T beta gamma were present, Gpp(NH)p and GTP gamma S decreased [32P]ADP-ribosylation by pertussis toxin. Adenosine Diphosphate 97-100 rhodopsin Homo sapiens 16-25 3863817-12 1985 Thus, pertussis toxin-catalyzed [32P]ADP-ribosylation of T alpha was affected by nucleotides, rhodopsin and light in addition to T beta gamma. Adenosine Diphosphate 37-40 rhodopsin Homo sapiens 94-103 2995383-11 1985 Norepinephrine or vasopressin increased the cytosolic ATP/ADP in the presence of atractyloside. Adenosine Diphosphate 58-61 arginine vasopressin Rattus norvegicus 18-29 2995350-8 1985 Arg-Gly-Asp-Ser, but not Arg-Gly-Tyr-Ser-Leu-Gly, also inhibited fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 65-75 2998235-8 1985 Since endothelial cells of the vascular intima contain receptors for thrombin, filling these receptors with thrombin becomes a stimulus for the production of prostacyclin (PGI2) by the endothelial cells; PGI2 in turn inhibits adherence of the small platelet aggregates by ADP; homeostasis is maintained. Adenosine Diphosphate 272-275 coagulation factor II, thrombin Homo sapiens 69-77 2998235-8 1985 Since endothelial cells of the vascular intima contain receptors for thrombin, filling these receptors with thrombin becomes a stimulus for the production of prostacyclin (PGI2) by the endothelial cells; PGI2 in turn inhibits adherence of the small platelet aggregates by ADP; homeostasis is maintained. Adenosine Diphosphate 272-275 coagulation factor II, thrombin Homo sapiens 108-116 4043093-0 1985 Fibrinogen distribution on surfaces and in organelles of ADP stimulated human blood platelets. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 0-10 4043093-1 1985 The fibrinogen distribution in platelet organelles after ADP-stimulation was investigated with anti-human fibrinogen using protein A-gold applied to serial sections. Adenosine Diphosphate 57-60 fibrinogen beta chain Homo sapiens 4-14 4043093-2 1985 Fibrinogen was detected in the so-called alpha-granules of platelets and also in granule protrusions which were observed after ADP-stimulation. Adenosine Diphosphate 127-130 fibrinogen beta chain Homo sapiens 0-10 2990572-5 1985 Addition of ADP to well-coupled mitochondria in the presence of an oxidizable substrate initiates the synthesis of glucose 6-phosphate via bound hexokinase. Adenosine Diphosphate 12-15 hexokinase 1 Homo sapiens 145-155 2991399-11 1985 Platelets incubated for 30 minutes with ADP and 125I-fibrinogen also showed an initial rise in quin-2 fluorescence, which returned to baseline levels during incubation, but the amount of platelet-bound fibrinogen, normal at the onset, remained quantitatively unchanged. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 202-212 2991399-1 1985 The mechanism of adenosine diphosphate (ADP)-induced refractoriness was explored with iodine 125-labeled fibrinogen and the fluorescent Ca+2 indicator quin-2-tetraacetoxymethyl ester (quin-2). Adenosine Diphosphate 17-38 fibrinogen beta chain Homo sapiens 105-115 2991399-1 1985 The mechanism of adenosine diphosphate (ADP)-induced refractoriness was explored with iodine 125-labeled fibrinogen and the fluorescent Ca+2 indicator quin-2-tetraacetoxymethyl ester (quin-2). Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 105-115 2996170-2 1985 SS inhibited dose-responsively ADP-induced aggregation in the presence of fibrinogen and Ca2+. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 74-84 4016157-1 1985 The time-course of ADP-triggered aggregation of human blood platelets has been followed by sensitive right-angle light scattering intensity measurements as a function of the platelet and fibrinogen concentrations. Adenosine Diphosphate 19-22 fibrinogen beta chain Homo sapiens 187-197 3161548-3 1985 The calculation of ratios of different components in the Mg2+-AMP, ADP and ATP system is used for the semi-quantitative description of regulation of rabbit muscle phosphofructokinase by adenyl nucleotides at pH 7.0, 7.5 and 8.0. Adenosine Diphosphate 67-70 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 163-182 2986713-1 1985 The reactivities of myeloperoxidase-H2O2-Cl- and sodium hypochlorite with amino acids, uric acid, NADH, ascorbic acid, ADP, albumin, haemoglobin, alpha 1-antitrypsin and some hydroxyl radical scavengers have been compared. Adenosine Diphosphate 119-122 myeloperoxidase Homo sapiens 20-35 3893523-1 1985 Platelet aggregation of an afibrinogenaemic patient"s platelet rich plasma (PRP) was greatly decreased when ADP was used for stimulation. Adenosine Diphosphate 108-111 complement component 4 binding protein alpha Homo sapiens 76-79 2991335-2 1985 To investigate this mechanism, our previously described murine monoclonal antibody (10E5) and a new monoclonal antibody (7E3), both of which block the binding of fibrinogen to platelets and bind to GPIIb and/or GPIIIa, were radiolabeled and their rates of binding to native and ADP-activated platelets were studied. Adenosine Diphosphate 278-281 fibrinogen beta chain Homo sapiens 162-172 4012675-3 1985 The results, which were highly consistent between different individuals, showed that fibrinogen increases aggregability as measured by the ADP ED50, the dose of adenosine diphosphate at which aggregation proceeds at half its maximum velocity. Adenosine Diphosphate 161-182 fibrinogen beta chain Homo sapiens 85-95 2579690-7 1985 Platelets activated with ADP in the presence of added fib, and subsequently incubated with anti-fib IgG, showed small particle clusters over the whole platelet surface. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 54-57 3158213-1 1985 The progressive stabilization of fibrinogen binding to ADP-treated platelets has been well described, but the nature of this interaction remains obscure. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 33-43 3158213-3 1985 It represented 16 +/- 11% (mean +/- SD, n = 10) of fibrinogen bound to ADP-treated platelets after 1 min and 52 +/- 11% of fibrinogen bound to these platelets after 60 min. Adenosine Diphosphate 71-74 fibrinogen beta chain Homo sapiens 51-61 2984300-6 1985 The number of antigenic sites for monoclonal antibody reacting with GPIIb/GPIIIa complex of adenosine diphosphate-stimulated platelets decreased from 34,200 +/- 5,940 to 19,500 +/- 9,680/platelet after recirculation (P less than or equal to 0.025). Adenosine Diphosphate 92-113 integrin subunit beta 3 Homo sapiens 74-80 3884627-7 1985 ADP and lactate levels were elevated after ischaemia and decreased after reperfusion in the insulin-group but not in the control-group. Adenosine Diphosphate 0-3 insulin Homo sapiens 92-99 2988200-1 1985 In the particles enriched with plasmatic membranes of target cells (human erythrocytes, skeletal muscles and adipocytes of rats) ATP was steadily formed within 1 min of incubation of the particles with insulin (4 microgram/ml) in the medium containing Tris-HCl buffer, pH 7.5, ADP, Mg2+, inorganic phosphate, NaF, during NADH oxidation in presence of cytochrome c and oxygen (30 degrees). Adenosine Diphosphate 277-280 insulin Homo sapiens 202-209 3992511-4 1985 The fibrinogen concentration in the suspending medium of rabbit platelets was 2.5 +/- 0.9 micrograms/10(9) platelets, and upon stimulation with 9 microM ADP it increased to 10.7 +/- 2.9 micrograms/10(9) platelets. Adenosine Diphosphate 153-156 fibrinogen beta chain Homo sapiens 4-14 3992511-6 1985 The presence of prostaglandin E1 reduced the fibrinogen concentration to approximately 1 micrograms/10(9) platelets and prevented aggregation and loss of fibrinogen when the platelets were stimulated with ADP. Adenosine Diphosphate 205-208 fibrinogen beta chain Homo sapiens 154-164 3992511-7 1985 With human platelets, the extracellular concentrations of fibrinogen and beta-thromboglobulin, expressed as percentages of the amount in the platelets, were similar, and the increase in fibrinogen concentration upon ADP stimulation (approximately 2%) was much lower than with rabbit platelets. Adenosine Diphosphate 216-219 fibrinogen beta chain Homo sapiens 186-196 3992511-8 1985 We conclude that rabbit platelets may release fibrinogen from their alpha-granules when stimulated with ADP, and that a portion of the released fibrinogen becomes available to support aggregation. Adenosine Diphosphate 104-107 fibrinogen beta chain Homo sapiens 46-56 3158347-2 1985 To allow measurements at 25 degrees C, pyruvate kinase and phosphoenolpyruvate were included in the dialysis media to rephosphorylate ADP formed by the weak ATPase action of phosphofructokinase. Adenosine Diphosphate 134-137 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 174-193 2983615-1 1985 Pyruvate,Pi dikinase regulatory protein (PDRP) has been highly purified from maize leaves, and its role in catalyzing both ADP-mediated inactivation (due to phosphorylation of a threonine residue) and Pi-mediated activation (due to dephosphorylation by phosphorolysis) of pyruvate,Pi dikinase has been confirmed. Adenosine Diphosphate 123-126 pyruvate, phosphate dikinase regulatory protein, chloroplastic Zea mays 0-39 2983615-1 1985 Pyruvate,Pi dikinase regulatory protein (PDRP) has been highly purified from maize leaves, and its role in catalyzing both ADP-mediated inactivation (due to phosphorylation of a threonine residue) and Pi-mediated activation (due to dephosphorylation by phosphorolysis) of pyruvate,Pi dikinase has been confirmed. Adenosine Diphosphate 123-126 pyruvate, phosphate dikinase regulatory protein, chloroplastic Zea mays 41-45 2983615-7 1985 Michaelis constants for orthophosphate and the above form of active pyruvate,Pi dikinase were determined, as well as the mechanism of inhibition of the PDRP-catalyzed reaction by ATP, ADP, AMP, and PPi. Adenosine Diphosphate 184-187 pyruvate, phosphate dikinase regulatory protein, chloroplastic Zea mays 152-156 3856279-4 1985 Without inhibitors or in the presence of glucose 1,6-bisphosphate,2,3-diphosphoglycerate, and ADP, maximum hexokinase activity was observed at 5 mM glucose concentration. Adenosine Diphosphate 94-97 hexokinase 1 Homo sapiens 107-117 3970930-2 1985 The biological activity of elongation factor 2 (EF-2) following NAD+ - and diphtheria-toxin-dependent ADP-ribosylation was studied (i) in translation experiments using the reticulocyte lysate system and (ii) in ribosomal binding experiments using either reconstituted empty rat liver ribosomes or programmed reticulocyte polysomes. Adenosine Diphosphate 102-105 eukaryotic translation elongation factor 2 Rattus norvegicus 27-46 3970930-2 1985 The biological activity of elongation factor 2 (EF-2) following NAD+ - and diphtheria-toxin-dependent ADP-ribosylation was studied (i) in translation experiments using the reticulocyte lysate system and (ii) in ribosomal binding experiments using either reconstituted empty rat liver ribosomes or programmed reticulocyte polysomes. Adenosine Diphosphate 102-105 eukaryotic translation elongation factor 2 Rattus norvegicus 48-52 3970930-5 1985 At this level of inhibition more than 90% of the EF-2 present in the lysates was ADP-ribosylated and the total ribosome association of EF-2 was reduced by approx. Adenosine Diphosphate 81-84 eukaryotic translation elongation factor 2 Rattus norvegicus 49-53 3970930-17 1985 The data indicate that the inhibition of translocation caused by diphtheria toxin and NAD+ is mediated through a reduced affinity of the ADP-ribosylated EF-2 for binding to ribosomes in the pretranslocation state. Adenosine Diphosphate 137-140 eukaryotic translation elongation factor 2 Rattus norvegicus 153-157 2981130-6 1985 Binding of 125I-fibrinogen following stimulation of platelets by ADP or collagen was greater in diabetic (because more binding sites were exposed) than in normal subjects. Adenosine Diphosphate 65-68 fibrinogen beta chain Homo sapiens 16-26 2996352-6 1985 Higher concentrations of PTH were required to prevent aggregation initiated by adenosine-5"-diphosphate, arachidonic acid, or platelet-aggregating factor. Adenosine Diphosphate 79-103 parathyroid hormone Homo sapiens 25-28 2981130-12 1985 The combined data suggest that the glycoprotein IIb-IIIa complex of platelets from diabetic subjects is similar to that of platelets from normal subjects and that the increased fibrinogen binding and aggregation of platelets from diabetic subjects in response to ADP or collagen is mediated by increased formation of prostaglandin endoperoxide or thromboxane A2, or both. Adenosine Diphosphate 263-266 fibrinogen beta chain Homo sapiens 177-187 3967486-3 1985 Using potassium ferricyanide or trypsin-solubilized liver cytochrome b5 (Tb5) as substrates, enzyme activity was inhibited by ADP and to a lesser extent by ATP. Adenosine Diphosphate 126-129 transforming growth factor beta regulator 1 Homo sapiens 73-76 6236859-1 1984 Two monoclonal antibodies--one that blocks ristocetin-induced platelet binding of von Willebrand factor to glycoprotein Ib and one that blocks adenosine diphosphate-induced binding of fibrinogen to the glycoprotein IIb/IIIa complex--were used to assess the binding site(s) for von Willebrand factor when platelets are stimulated with thrombin or adenosine diphosphate (ADP). Adenosine Diphosphate 143-164 fibrinogen beta chain Homo sapiens 184-194 3938969-10 1985 In the presence of G beta gamma and photolyzed rhodopsin, GDP and GDP beta S, but not Gpp(NH)p and GTP gamma S, increased the ADP-ribosylation of Gi alpha. Adenosine Diphosphate 126-129 rhodopsin Homo sapiens 47-56 6439719-0 1984 Effects of guanyl nucleotides and rhodopsin on ADP-ribosylation of the inhibitory GTP-binding component of adenylate cyclase by pertussis toxin. Adenosine Diphosphate 47-50 rhodopsin Homo sapiens 34-43 6439719-7 1984 Photolyzed rhodopsin, but not the inactive, dark protein, inhibited ADP-ribosylation of Gi alpha in the presence of G beta gamma. Adenosine Diphosphate 68-71 rhodopsin Homo sapiens 11-20 6498335-8 1984 Furthermore, shear-induced PAG in C-PRP as well as ADP- and collagen-induced PAG in C-PRP in the aggregometer was significantly inhibited by 5 mumol/L CPZ, indicating that the observed reduced potentiation of shear-induced PAG by RBCs in the presence of CPZ was due to a direct inhibitory effect of the drug on platelets rather than a reduction of shear-induced liberation of ADP from RBCs. Adenosine Diphosphate 51-54 prion protein Homo sapiens 86-89 6092363-1 1984 Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase catalyzes exchange reactions between ADP and ATP and between fructose-6-P and fructose-2,6-P2 at histidyl residues. Adenosine Diphosphate 100-103 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Rattus norvegicus 10-62 2997067-3 1985 The addition of the aggregating substance (ADP, collagen) to PRP but not to PPP was followed by PMN activation as shown by enzyme release and O-2 generation. Adenosine Diphosphate 43-46 prion protein Homo sapiens 61-64 6437459-0 1984 Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets. Adenosine Diphosphate 97-100 fibrinogen beta chain Homo sapiens 59-69 6437459-1 1984 When platelets are stimulated with adenosine diphosphate (ADP), fibrinogen binds to receptors on the platelet membrane, and the platelets aggregate. Adenosine Diphosphate 35-56 fibrinogen beta chain Homo sapiens 64-74 6437459-1 1984 When platelets are stimulated with adenosine diphosphate (ADP), fibrinogen binds to receptors on the platelet membrane, and the platelets aggregate. Adenosine Diphosphate 58-61 fibrinogen beta chain Homo sapiens 64-74 6437459-6 1984 In binding and aggregation experiments, we detected no significant differences between the reactions of the first two fractions, but ADP-stimulated platelets bound only 50% as much of 125I-fibrinogen from the fraction with the gamma" chains and also aggregated less extensively in the presence of this fraction. Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 189-199 6437459-7 1984 We conclude that the sialic acid content of fibrinogen does not significantly affect its interactions with platelets, but the elongated gamma" chains bind less effectively to ADP-stimulated platelets, and thus reduce the ability of fibrinogen to support aggregation. Adenosine Diphosphate 175-178 fibrinogen beta chain Homo sapiens 232-242 6506112-2 1984 A large craniectomy was performed and vasoconstriction was induced by the subarachnoid injection of human platelet-rich plasma (PRP) pretreated with 25 mu M of ADP to cause maximum aggregation. Adenosine Diphosphate 160-163 complement component 4 binding protein alpha Homo sapiens 106-126 6506112-2 1984 A large craniectomy was performed and vasoconstriction was induced by the subarachnoid injection of human platelet-rich plasma (PRP) pretreated with 25 mu M of ADP to cause maximum aggregation. Adenosine Diphosphate 160-163 complement component 4 binding protein alpha Homo sapiens 128-131 6236976-13 1984 In both cases calmodulin acts synergistic with AMP and ADP. Adenosine Diphosphate 55-58 calmodulin 1 Homo sapiens 14-24 6236976-14 1984 To a minor degree calmodulin also counteracts the stabilization of the tetrameric form caused by fructose 6-phosphate and hexose bisphosphate, now however antagonistically to AMP and ADP. Adenosine Diphosphate 183-186 calmodulin 1 Homo sapiens 18-28 6540783-1 1984 Using hexokinase, glucose, and ATP to vary reversibly the concentrations of ADP and ATP in solution and bound to Acanthamoeba actin, I measured the relative critical concentrations and elongation rate constants for ATP-actin and ADP-actin in 50 mM KCl, 1 mM MgCl2, 1 mM EGTA, 0.1 mM nucleotide, 0.1 mM CaCl2, 10 mM imidazole, pH 7. Adenosine Diphosphate 76-79 hexokinase 1 Homo sapiens 6-16 6326566-2 1984 Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP. Adenosine Diphosphate 226-229 fibrinogen beta chain Homo sapiens 145-155 6495268-2 1984 125I-fibrinogen binding during ADP-induced aggregation, and release of amine storage granule contents were also inhibited. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 5-15 6088225-0 1984 Platelet aggregation: its relation with ADP-induced fibrinogen binding to platelets and ADP-related membrane enzyme activities. Adenosine Diphosphate 40-43 fibrinogen beta chain Homo sapiens 52-62 6088225-3 1984 In the present study, experiments were conducted with washed human platelets to examine if a relationship existed between platelet aggregation, fibrinogen binding and the enzymatic degradation of ADP. Adenosine Diphosphate 196-199 fibrinogen beta chain Homo sapiens 144-154 6088225-4 1984 With 12 different platelet suspensions, a good correlation (P less than 0.01) was found between the extent of platelet aggregation and the amount of 125I-fibrinogen bound to platelets after ADP stimulation. Adenosine Diphosphate 190-193 fibrinogen beta chain Homo sapiens 154-164 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Diphosphate 87-90 fibrinogen beta chain Homo sapiens 15-25 6088225-6 1984 The binding of fibrinogen to platelets was inhibited in parallel with aggregation when ADP stimulation was impaired by the enzymatic degradation of ADP by the system creatine phosphate/creatine phosphokinase, or by the use of specific antagonists, such as ATP and AMP. Adenosine Diphosphate 148-151 fibrinogen beta chain Homo sapiens 15-25 6088225-9 1984 Our results demonstrate that ATP and AMP may be used as specific antagonists of the ADP-induced fibrinogen binding to platelets. Adenosine Diphosphate 84-87 fibrinogen beta chain Homo sapiens 96-106 6379307-11 1984 The mean ADP content was 1.43 mumol/gm in the insulin group versus 1.81 mumol/gm in the control group. Adenosine Diphosphate 9-12 insulin Homo sapiens 46-53 6087354-8 1984 Conversely, unlabeled vWF inhibited ADP-induced binding of 125I-labeled fibrinogen (60 micrograms/ml) with an IC50 of 16 micrograms/ml. Adenosine Diphosphate 36-39 von Willebrand factor Homo sapiens 22-25 6087354-8 1984 Conversely, unlabeled vWF inhibited ADP-induced binding of 125I-labeled fibrinogen (60 micrograms/ml) with an IC50 of 16 micrograms/ml. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 72-82 6087354-9 1984 A synthetic dodecapeptide (Mr, 1188), analogous with the specific platelet receptor recognition site of human fibrinogen gamma chain (gamma 400-411), inhibited binding of both 125I-labeled vWF and 125I-labeled fibrinogen to ADP-treated platelets, whereas it was without effect on binding of 125I-labeled vWF to ristocetin-treated platelets. Adenosine Diphosphate 224-227 fibrinogen gamma chain Homo sapiens 110-147 6087354-9 1984 A synthetic dodecapeptide (Mr, 1188), analogous with the specific platelet receptor recognition site of human fibrinogen gamma chain (gamma 400-411), inhibited binding of both 125I-labeled vWF and 125I-labeled fibrinogen to ADP-treated platelets, whereas it was without effect on binding of 125I-labeled vWF to ristocetin-treated platelets. Adenosine Diphosphate 224-227 von Willebrand factor Homo sapiens 189-192 6087354-9 1984 A synthetic dodecapeptide (Mr, 1188), analogous with the specific platelet receptor recognition site of human fibrinogen gamma chain (gamma 400-411), inhibited binding of both 125I-labeled vWF and 125I-labeled fibrinogen to ADP-treated platelets, whereas it was without effect on binding of 125I-labeled vWF to ristocetin-treated platelets. Adenosine Diphosphate 224-227 fibrinogen beta chain Homo sapiens 110-120 6087354-10 1984 These data indicate that vWF and fibrinogen have a common receptor mechanism for their interaction with human platelets that is dependent on ADP occupancy of its binding sites and is recognized by the sequence of 12 amino acid residues at the carboxyl terminus of the human fibrinogen gamma chain. Adenosine Diphosphate 141-144 von Willebrand factor Homo sapiens 25-28 6087354-10 1984 These data indicate that vWF and fibrinogen have a common receptor mechanism for their interaction with human platelets that is dependent on ADP occupancy of its binding sites and is recognized by the sequence of 12 amino acid residues at the carboxyl terminus of the human fibrinogen gamma chain. Adenosine Diphosphate 141-144 fibrinogen beta chain Homo sapiens 33-43 6087354-10 1984 These data indicate that vWF and fibrinogen have a common receptor mechanism for their interaction with human platelets that is dependent on ADP occupancy of its binding sites and is recognized by the sequence of 12 amino acid residues at the carboxyl terminus of the human fibrinogen gamma chain. Adenosine Diphosphate 141-144 fibrinogen gamma chain Homo sapiens 274-296 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 75-96 fibrinogen beta chain Homo sapiens 111-121 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 75-96 coagulation factor II, thrombin Homo sapiens 192-200 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 111-121 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 98-101 coagulation factor II, thrombin Homo sapiens 192-200 6733283-1 1984 We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin. Adenosine Diphosphate 170-173 fibrinogen beta chain Homo sapiens 111-121 6733283-9 1984 These data suggest that the fibrinogen receptor on chymotrypsin-treated platelets is identical to that on ADP-treated platelets and that this receptor is either near to, or on, the glycoprotein IIb/IIIa complex. Adenosine Diphosphate 106-109 fibrinogen beta chain Homo sapiens 28-38 6743276-7 1984 The physiological relevance with respect to pyruvate metabolism, i.e. regulation of pyruvate carboxylase and pyruvate dehydrogenase by the mitochondrial ATP/ADP ratio, is discussed. Adenosine Diphosphate 157-160 pyruvate carboxylase Homo sapiens 84-104 6233383-4 1984 All patients had significant dense granule storage pool depletion (thrombin-releasable ADP was 0.59 +/- 0.30 vs. 2.41 +/- 0.20 mumol per 10(11) platelets in patients compared with normal volunteers; total platelet ADP was 0.97 +/- 0.29 vs. 2.72 +/- 0.15, and total platelet ATP/ADP was 4.77 +/- 1.89 vs. 1.65 +/- 0.11). Adenosine Diphosphate 87-90 coagulation factor II, thrombin Homo sapiens 67-75 6233383-5 1984 The prolongation in bleeding time correlated inversely with thrombin-releasable ADP (r = -0.637, p less than 0.01) and with total ADP (r = -0.832, p less than 0.005), and directly with the ATP/ADP ratio (r = 0.781, p less than 0.005). Adenosine Diphosphate 80-83 coagulation factor II, thrombin Homo sapiens 60-68 6377570-2 1984 Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in response to ADP or thrombin. Adenosine Diphosphate 5-8 coagulation factor II, thrombin Homo sapiens 122-130 6377570-2 1984 Both ADP- and thrombin-induced aggregation were inhibited as was the biosynthesis of thromboxane A2 in response to ADP or thrombin. Adenosine Diphosphate 115-118 coagulation factor II, thrombin Homo sapiens 14-22 6327687-0 1984 Mechanism of the inhibition of Ca2+, Mg2+-dependent endonuclease of bull seminal plasma induced by ADP-ribosylation. Adenosine Diphosphate 99-102 mucolipin TRP cation channel 1 Homo sapiens 37-40 6100417-1 1984 The influence was studied in vitro of certain agents (adenosine, ADP, ATP, theophylline, together with F- ions) on the cAMP concentrations in the nuclear (N) and mitochondrial (M) fractions from different areas of rat brain. Adenosine Diphosphate 65-68 cathelicidin antimicrobial peptide Rattus norvegicus 119-123 6089753-2 1984 The labile phosphoryl groups of ATP and ADP as well as Pi in the metabolic pool of these platelets had equal specific radioactivity which was identical to that of[32P]phosphatidate formed during treatment of the cells with thrombin for 5 min. Adenosine Diphosphate 40-43 coagulation factor II, thrombin Homo sapiens 223-231 6087354-3 1984 Binding of 125I-labeled vWF to human platelets separated from plasma proteins and treated with ADP was specific, and time and concentration dependent, reaching equilibrium at 20 min and approaching saturation at 12 micrograms/ml. Adenosine Diphosphate 95-98 von Willebrand factor Homo sapiens 24-27 6087354-5 1984 A purine nucleotide affinity analog, 5"-p-fluorosulfonylbenzoyl adenosine (FSBA), which covalently modifies the ADP binding sites on the human platelet membrane, prevented binding of vWF induced with ADP, as well as with human thrombin and with ionophore A23187, agents known to cause platelet ADP secretion. Adenosine Diphosphate 112-115 von Willebrand factor Homo sapiens 183-186 6087354-5 1984 A purine nucleotide affinity analog, 5"-p-fluorosulfonylbenzoyl adenosine (FSBA), which covalently modifies the ADP binding sites on the human platelet membrane, prevented binding of vWF induced with ADP, as well as with human thrombin and with ionophore A23187, agents known to cause platelet ADP secretion. Adenosine Diphosphate 200-203 von Willebrand factor Homo sapiens 183-186 6087354-5 1984 A purine nucleotide affinity analog, 5"-p-fluorosulfonylbenzoyl adenosine (FSBA), which covalently modifies the ADP binding sites on the human platelet membrane, prevented binding of vWF induced with ADP, as well as with human thrombin and with ionophore A23187, agents known to cause platelet ADP secretion. Adenosine Diphosphate 200-203 von Willebrand factor Homo sapiens 183-186 6087354-7 1984 Human fibrinogen inhibited in a competitive manner the ADP-induced binding of 125I-labeled vWF (9 micrograms/ml) with an IC50 of 25 micrograms/ml. Adenosine Diphosphate 55-58 fibrinogen beta chain Homo sapiens 6-16 6087354-7 1984 Human fibrinogen inhibited in a competitive manner the ADP-induced binding of 125I-labeled vWF (9 micrograms/ml) with an IC50 of 25 micrograms/ml. Adenosine Diphosphate 55-58 von Willebrand factor Homo sapiens 91-94 6326566-3 1984 The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates. Adenosine Diphosphate 116-119 fibrinogen beta chain Homo sapiens 58-68 6326566-4 1984 When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone. Adenosine Diphosphate 86-89 fibrinogen beta chain Homo sapiens 127-137 6326566-4 1984 When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone. Adenosine Diphosphate 86-89 coagulation factor II, thrombin Homo sapiens 215-223 6326566-6 1984 While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination. Adenosine Diphosphate 11-14 fibrinogen beta chain Homo sapiens 63-73 6326566-6 1984 While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 131-139 6736560-2 1984 In a subsequent incubation in the presence of pyruvate kinase, phosphoenolpyruvate, radioactive glucose and hexokinase, ATP and ADP are estimated together by coupling their recycling to the formation of glucose 6-phosphate. Adenosine Diphosphate 128-131 hexokinase 1 Homo sapiens 108-118 6329175-3 1984 Responses to epinephrine (via alpha-2 adrenoreceptors) and ADP were independent of extracellular Ca2+, but required maintained occupancy of thrombin receptors and intact cAMP-phosphodiesterase activity. Adenosine Diphosphate 59-62 coagulation factor II, thrombin Homo sapiens 140-148 6424261-6 1984 Consequently, the ADP- and adrenaline-induced secondary aggregation and [3H]serotonin release in citrated PRP and the major effects of collagen were also inhibited. Adenosine Diphosphate 18-21 prion protein Homo sapiens 106-109 6203747-6 1984 Conventional antiserum raised against purified GPIIIa also blocks the aggregation induced by ADP. Adenosine Diphosphate 93-96 integrin subunit beta 3 Homo sapiens 47-53 6231056-4 1984 In the homogeneous control system composed of hexokinase and glucose as ATPase, soluble creatine kinase rapidly rephosphorylated ADP produced in the presence of 1 mM ATP, but the addition of pyruvate kinase in an increasing amount inhibited the reaction of creatine release from phosphocreatine and symmetrically increased the rate of pyruvate production from phosphoenol pyruvate. Adenosine Diphosphate 129-132 hexokinase 1 Homo sapiens 46-56 6324004-3 1984 Two apparently distinct mechanisms have now been identified for enhancing 125I-vWF interaction with stimulated platelets: one is induced by ristocetin and apparently mediated by platelet membrane glycoprotein Ib (GPIb); a second mechanism has been identified more recently and is induced by the physiological stimuli ADP and thrombin. Adenosine Diphosphate 317-320 von Willebrand factor Homo sapiens 79-82 6324004-5 1984 As ADP and thrombin are released at sites of platelet accumulation, it is possible that these agonists regulate the vWF-platelet interactions in vivo. Adenosine Diphosphate 3-6 von Willebrand factor Homo sapiens 116-119 6324004-6 1984 To test this hypothesis, we have examined ADP- and thrombin-supported 125I-vWF binding to platelets in the plasma of severe vWD patients, and report here that it is inhibited by fibrinogen. Adenosine Diphosphate 42-45 fibrinogen beta chain Homo sapiens 178-188 6324004-7 1984 Thus, in addition to its role in coagulation and platelet aggregation, fibrinogen influences the binding of vWF to thrombin- and ADP-stimulated platelets. Adenosine Diphosphate 129-132 fibrinogen beta chain Homo sapiens 71-81 6324004-7 1984 Thus, in addition to its role in coagulation and platelet aggregation, fibrinogen influences the binding of vWF to thrombin- and ADP-stimulated platelets. Adenosine Diphosphate 129-132 von Willebrand factor Homo sapiens 108-111 6326808-2 1984 Binding of fibrinogen to human platelets depends on the interaction of the gamma-chain carboxy-terminal segment with specific receptors exposed by different agonists such as ADP, epinephrine, and thrombin. Adenosine Diphosphate 174-177 fibrinogen beta chain Homo sapiens 11-21 6326808-4 1984 Both pentadecapeptide (gamma 397-411) and dodecapeptide (gamma 400-411) inhibited binding of 125I-fibrinogen to ADP-treated platelets, with the concentration causing 50% inhibition (IC50) being 28 microM. Adenosine Diphosphate 112-115 fibrinogen beta chain Homo sapiens 98-108 6424707-5 1984 For saturating levels of thrombin the delay was 1.5 s and release was 90% complete within 6-7 s. The delay could not be shortened by prestimulation under conditions that induce shape changes but not release, i.e., with ADP, arachidonic acid, or low levels of thrombin or A23187. Adenosine Diphosphate 219-222 coagulation factor II, thrombin Homo sapiens 25-33 6324859-11 1984 Results on the reaction mechanism of myokinase with adenosine 5"-arsenate indicate that the mixed-anhydride analogue to ADP, adenosine 5"-(arsenate phosphate), is not detected either because it is not formed in the reaction with this enzyme or because it is rapidly hydrolyzed. Adenosine Diphosphate 120-123 adenylate kinase 1 Homo sapiens 37-46 6230372-2 1984 Plasma proteins specifically inhibited the thrombin- and ADP/epinephrine-induced vWf binding to activated platelets but did not inhibit the ristocetin-induced vWf binding. Adenosine Diphosphate 57-60 von Willebrand factor Homo sapiens 81-84 6230372-3 1984 When normal plasma was heat defibrinated, monoclonal-labeled vWf was bound to platelets following thrombin or ADP/epinephrine stimulation. Adenosine Diphosphate 110-113 von Willebrand factor Homo sapiens 61-64 6230372-8 1984 These studies show that thrombin-induced and ADP/epinephrine-induced vWf binding to platelets does not occur in the plasma milieu, although at reduced levels of fibrinogen, vWf binding to stimulated platelets can be demonstrated. Adenosine Diphosphate 45-48 von Willebrand factor Homo sapiens 69-72 6743778-2 1984 In vitro, pCT at a concentration ranging from 0.1 to 5 M. R. C. Units/ml induced a dose-dependent inhibition of ADP (1.2 microM) and collagen- (2 micrograms/ml) induced platelet aggregation, showing a prevalent action on the second wave of ADP-induced aggregation and causing prolongation of the lag time and reduction of both maximum aggregation and slope in collagen-induced aggregation. Adenosine Diphosphate 112-115 calcitonin related polypeptide alpha Homo sapiens 10-13 6423017-2 1984 Adenosine diphosphate (ADP)-induced platelet aggregation was inhibited in CO2-treated PRP. Adenosine Diphosphate 0-21 complement component 4 binding protein alpha Homo sapiens 86-89 6423017-2 1984 Adenosine diphosphate (ADP)-induced platelet aggregation was inhibited in CO2-treated PRP. Adenosine Diphosphate 23-26 complement component 4 binding protein alpha Homo sapiens 86-89 6386144-6 1984 Generation of thrombin or other tumor mechanisms activate platelets, leading to direct aggregation or secretion of ADP, serotonin, and/or intermediates of the arachidonate metabolism. Adenosine Diphosphate 115-118 coagulation factor II, thrombin Homo sapiens 14-22 6323960-1 1984 Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. Adenosine Diphosphate 0-21 fibrinogen beta chain Homo sapiens 86-96 6323960-1 1984 Adenosine diphosphate (ADP) is known to induce platelet shape change, aggregation and fibrinogen binding, followed by secretion. Adenosine Diphosphate 23-26 fibrinogen beta chain Homo sapiens 86-96 6323960-9 1984 The ability of FSBA to inhibit platelet aggregation and fibrinogen binding by prostaglandin H2 derivatives and epinephrine suggest that ADP is involved in these processes. Adenosine Diphosphate 136-139 fibrinogen beta chain Homo sapiens 56-66 6100105-2 1984 We found that antisera raised in rabbits against membranes prepared from human intact, chymotrypsin- or pronase-treated platelets inhibited the fibrinogen-induced aggregations of ADP-stimulated intact platelets, chymotrypsin-treated platelets and pronase-treated platelets. Adenosine Diphosphate 179-182 fibrinogen beta chain Homo sapiens 144-154 6100105-3 1984 These antisera also blocked the binding of 125I-fibrinogen to ADP-stimulated intact, chymotrypsin-treated, and pronase-treated platelets. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 6100105-10 1984 It is proposed that the 66 000 Mr protein may be the fibrinogen binding domain of GPIII which becomes permanently exposed on the surface of chymotrypsin and pronase-treated platelets following proteolysis and which becomes exposed upon stimulation of intact platelets by agents such as ADP. Adenosine Diphosphate 286-289 fibrinogen beta chain Homo sapiens 53-63 6743778-2 1984 In vitro, pCT at a concentration ranging from 0.1 to 5 M. R. C. Units/ml induced a dose-dependent inhibition of ADP (1.2 microM) and collagen- (2 micrograms/ml) induced platelet aggregation, showing a prevalent action on the second wave of ADP-induced aggregation and causing prolongation of the lag time and reduction of both maximum aggregation and slope in collagen-induced aggregation. Adenosine Diphosphate 240-243 calcitonin related polypeptide alpha Homo sapiens 10-13 6743778-4 1984 The in vivo tests, performed before and after a 7-day treatment with 2 different doses of pCT (1 and 160 M. R. C. Units/daily, i. m.) confirmed the inhibitory effect of pCT on ADP- and collagen-induced platelet aggregation. Adenosine Diphosphate 176-179 calcitonin related polypeptide alpha Homo sapiens 90-93 6743778-4 1984 The in vivo tests, performed before and after a 7-day treatment with 2 different doses of pCT (1 and 160 M. R. C. Units/daily, i. m.) confirmed the inhibitory effect of pCT on ADP- and collagen-induced platelet aggregation. Adenosine Diphosphate 176-179 calcitonin related polypeptide alpha Homo sapiens 169-172 6417817-0 1983 Adhesion and aggregation of thrombin prestimulated human platelets on surface-bound fibrinogen: evidence for involvement of ADP and arachidonic acid pathways. Adenosine Diphosphate 124-127 coagulation factor II, thrombin Homo sapiens 28-36 6417817-9 1983 For adhesion and cohesion, aggregation, in the presence of sufficient thrombin for prestimulation, 0.05 U/ml, ADP, serotonin and substances from arachidonic acid metabolism acted jointly to stimulate platelets. Adenosine Diphosphate 110-113 coagulation factor II, thrombin Homo sapiens 70-78 6228252-6 1983 The presence of allosteric activators, either ADP or cAMP, enhances the association of the inactivated PFK without changing its stoichiometry, an observation similar to that of the native enzyme. Adenosine Diphosphate 46-49 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 103-106 6653942-3 1983 In 28 diabetic children the platelet shape change after ADP stimulation was positively correlated with the serum concentration of apolipoprotein A-I and negatively correlated with serum triglyceride concentration. Adenosine Diphosphate 56-59 apolipoprotein A1 Homo sapiens 130-148 6226659-6 1983 AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid. Adenosine Diphosphate 14-17 coagulation factor II, thrombin Homo sapiens 321-329 6309797-7 1983 These data indicate that the cytoplasm is a potential source for the requirement of 10(-6) M Ca2+, and that changes in the intracellular concentration of Ca2+ may cause the expression of fibrinogen receptors during ADP-induced platelet activation. Adenosine Diphosphate 215-218 fibrinogen beta chain Homo sapiens 187-197 6419373-1 1983 Human Factor VIII associated von Willebrand factor (VIII:vWF) binds to human platelets in vitro only in the presence of a mediator such as ristocetin, thrombin or ADP. Adenosine Diphosphate 163-166 von Willebrand factor Homo sapiens 57-60 6411841-4 1983 When PRP was stimulated with subthreshold concentrations of the Ca++ ionophore A23187 followed by subthreshold concentrations of ADP or epinephrine, a marked potentiation of platelet aggregation and TXA2 generation was observed. Adenosine Diphosphate 129-132 prion protein Homo sapiens 5-8 6224505-4 1983 In functional assays these two antibodies could specifically inhibit ADP and collagen induced aggregation of platelets and release of ATP, retard platelet aggregation and ATP release induced by epinephrine, and inhibit ADP induced platelet fibrinogen binding. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 240-250 6224505-4 1983 In functional assays these two antibodies could specifically inhibit ADP and collagen induced aggregation of platelets and release of ATP, retard platelet aggregation and ATP release induced by epinephrine, and inhibit ADP induced platelet fibrinogen binding. Adenosine Diphosphate 219-222 fibrinogen beta chain Homo sapiens 240-250 6416107-2 1983 Both procedures are based on the measurement of ADP formed during enzymatic phosphorylation of the analogs either by hexokinase or by fructokinase. Adenosine Diphosphate 48-51 hexokinase 1 Homo sapiens 117-127 6411841-5 1983 Incubation of PRP with diltiazem in a pharmacologic range resulted in marked reduction in ionophore A23187-induced potentiation of platelet activity caused by ADP or epinephrine. Adenosine Diphosphate 159-162 prion protein Homo sapiens 14-17 6301579-0 1983 Exposure of fibrinogen receptors on fresh and stored platelets by ADP and epinephrine as single agents and as a pair. Adenosine Diphosphate 66-69 fibrinogen beta chain Homo sapiens 12-22 20217998-5 1983 Prothrombin and active factor X enhance ADP-induced platelet-fg binding whereas active factor VIII and active factor IX, separately or combined, are without effect. Adenosine Diphosphate 40-43 coagulation factor II, thrombin Homo sapiens 0-11 6407547-6 1983 We conclude that arachidonic acid, collagen, and thrombin can expose binding sites for factor VIII independently of released ADP; that Ca++ is required for activation but probably not for binding of factor VIII to platelets; and that platelet thromboxane synthesis plays a major role in the binding of factor VIII to platelets induced by thrombin, ADP, or collagen. Adenosine Diphosphate 125-128 coagulation factor II, thrombin Homo sapiens 49-57 6407547-6 1983 We conclude that arachidonic acid, collagen, and thrombin can expose binding sites for factor VIII independently of released ADP; that Ca++ is required for activation but probably not for binding of factor VIII to platelets; and that platelet thromboxane synthesis plays a major role in the binding of factor VIII to platelets induced by thrombin, ADP, or collagen. Adenosine Diphosphate 348-351 coagulation factor II, thrombin Homo sapiens 49-57 6223940-1 1983 The binding of 125I-von Willebrand factor (125I-vWF) to platelets stimulated by thrombin, ADP, and a combination of ADP + epinephrine (EPI) is specific, saturable, and reversible. Adenosine Diphosphate 90-93 von Willebrand factor Homo sapiens 20-41 6223940-1 1983 The binding of 125I-von Willebrand factor (125I-vWF) to platelets stimulated by thrombin, ADP, and a combination of ADP + epinephrine (EPI) is specific, saturable, and reversible. Adenosine Diphosphate 90-93 von Willebrand factor Homo sapiens 48-51 6308050-4 1983 ADP- and epinephrine-induced release of ATP was completely inhibited by the antibody, but inhibition of release induced by collagen and thrombin was dose dependent and partial. Adenosine Diphosphate 0-3 coagulation factor II, thrombin Homo sapiens 136-144 6307105-1 1983 In summary: Incubation of platelets with ADP or proteolytic enzymes (chymotrypsin or pronase) results in an exposure of two classes of specific binding sites on platelet surface: low and high affinity fibrinogen receptors. Adenosine Diphosphate 41-44 fibrinogen beta chain Homo sapiens 201-211 6307106-1 1983 Fibrinogen participates in platelet aggregation induced by ADP and this participation is receptor mediated. Adenosine Diphosphate 59-62 fibrinogen beta chain Homo sapiens 0-10 6636032-1 1983 Fibrinogen plays an integral part in ADP-induced platelet aggregation. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 0-10 6636032-6 1983 These fibrinogen fractions equally promoted ADP-induced platelet aggregation. Adenosine Diphosphate 44-47 fibrinogen beta chain Homo sapiens 6-16 6301579-3 1983 Following stimulation with 10 microM ADP or 20 microM epinephrine, platelet suspensions from fresh concentrates bound 125I-fibrinogen in a reaction that reached completion within 30 min. Adenosine Diphosphate 37-40 fibrinogen beta chain Homo sapiens 123-133 6301579-4 1983 Significantly less binding occurred in suspensions from platelet concentrates that had been stored for 5 days at 22 degrees C. When stimulated by ADP and epinephrine as a pair (2 microM each), binding of fibrinogen to platelets was complete within 10-15 min and was not significantly decreased in suspensions from stored concentrates. Adenosine Diphosphate 146-149 fibrinogen beta chain Homo sapiens 204-214 6301579-8 1983 We conclude that storage for 5 days at 22 degrees C impairs the exposure of fibrinogen receptors on platelets in response to ADP or epinephrine when used as single agents, without affecting the glycoprotein IIb-IIIa complex quantitatively. Adenosine Diphosphate 125-128 fibrinogen beta chain Homo sapiens 76-86 6188157-0 1983 Reversal of Rous sarcoma-specific immunoglobulin phosphorylation on tyrosine (ADP as phosphate acceptor) catalyzed by the src gene kinase. Adenosine Diphosphate 78-81 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 122-125 6223667-8 1983 It may be concluded that the Mg2+-dependent inactivation of CF1-ATPase is induced by the tightly bound ADP. Adenosine Diphosphate 103-106 mucolipin TRP cation channel 1 Homo sapiens 29-32 6612681-6 1983 Indomethacin (1 microgram/ml), a cyclooxygenase inhibitor, remarkably inhibited epinephrine plus ADP induced serotonin release, 40K-dalton protein phosphorylation and DG production although this agent had little effect on the same reactions induced by thrombin. Adenosine Diphosphate 97-100 coagulation factor II, thrombin Homo sapiens 252-260 6302680-4 1983 A2A9 was also a competitive inhibitor of fibrinogen binding to ADP-stimulated platelets. Adenosine Diphosphate 63-66 fibrinogen beta chain Homo sapiens 41-51 6832366-1 1983 Uptake of Ca2+ by rat brain mitochondria causes an inhibition of respiratory stimulation by ADP, and the inhibition is relieved upon Na+-induced release of Ca2+ from the mitochondria, in accordance with earlier reports. Adenosine Diphosphate 92-95 carbonic anhydrase 2 Rattus norvegicus 10-13 6827176-0 1983 Binding of fibrinogen to ADP-treated platelets. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 11-21 6859536-2 1983 In the assay, production of ATP from carbamoyl phosphate and ADP by carbamate kinase is coupled to the formation of NADPH, using glucose, hexokinase, NADP+, and glucose-6-phosphate dehydrogenase. Adenosine Diphosphate 61-64 hexokinase 1 Homo sapiens 138-148 6857606-2 1983 Inhibition by CP/CPK has become accepted as evidence for mediation by secreted ADP, yet primary aggregation is not usually attributed to secreted ADP. Adenosine Diphosphate 79-82 cystin 1 Mus musculus 14-20 6132622-8 1983 The ADP derivatives were good substrates for creatine kinase and glutamine synthetase (gamma-glutamyl transfer activity). Adenosine Diphosphate 4-7 glutamate-ammonia ligase Homo sapiens 65-85 6827176-4 1983 We found that fibrinogen derivatives, isolated from plasma or obtained after limited plasmin digestion, that lacked approximately 13,000 to 46,000 MW peptides from the carboxyterminal of their A alpha chains (I-6, I-9, I-9D88) displayed undiminished capacity to support ADP-induced platelet aggregation and to bind to gel-filtered platelets. Adenosine Diphosphate 270-273 fibrinogen beta chain Homo sapiens 14-24 6827176-11 1983 Its binding to ADP-treated platelets was quantitatively similar to that of intact fibrinogen but its Scatchard plot was linear, with loss of low-affinity binding. Adenosine Diphosphate 15-18 fibrinogen beta chain Homo sapiens 82-92 6189236-2 1983 Unfractionated heparin increased the binding of fibrinogen on ADP-treated platelets. Adenosine Diphosphate 62-65 fibrinogen beta chain Homo sapiens 48-58 6678100-4 1983 Myokinase contributes to the stabilization of an ATP/ADP ratio within narrow limits. Adenosine Diphosphate 53-56 adenylate kinase 1 Homo sapiens 0-9 6848504-1 1983 Thrombin-stimulated platelet secretion is accompanied by a 30% reduction in the steady state level of cytosolic ATP, a breakdown that proceeds through ADP, AMP, IMP, and inosine to hypoxanthine. Adenosine Diphosphate 151-154 coagulation factor II, thrombin Homo sapiens 0-8 6339782-3 1983 The administration of GIP mixture during the acute phase of myocardial infarction was conducive to lowering the levels of cyclic nucleotides and AMP, and raising blood ATP and ADP values. Adenosine Diphosphate 176-179 gastric inhibitory polypeptide Homo sapiens 22-25 6299197-3 1983 5"-Nucleotidase is bound very strongly by an affinity column containing a bound phosphonate analog of ADP but is not bound by an affinity column containing a non nucleotide phosphonate which selectively binds alkaline phosphatase. Adenosine Diphosphate 102-105 5'-nucleotidase Bos taurus 0-15 6615246-5 1983 Very low density lipoprotein and low density lipoprotein increased thrombin-induced platelet aggregation and [14C] serotonin release induced by epinephrine, ADP, and thrombin. Adenosine Diphosphate 157-160 coagulation factor II, thrombin Homo sapiens 67-75 6216929-0 1983 Exposure of platelet fibrinogen-binding sites by collagen, arachidonic acid, and ADP: inhibition by a monoclonal antibody to the glycoprotein IIb-IIIa complex. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 21-31 6216929-1 1983 Following stimulation with adenosine diphosphate (ADP), collagen, or arachidonic acid, unstirred human platelet suspensions bind 125I-fibrinogen in a reaction that reaches completion within 30 min. Adenosine Diphosphate 27-48 fibrinogen beta chain Homo sapiens 134-144 6216929-1 1983 Following stimulation with adenosine diphosphate (ADP), collagen, or arachidonic acid, unstirred human platelet suspensions bind 125I-fibrinogen in a reaction that reaches completion within 30 min. Adenosine Diphosphate 50-53 fibrinogen beta chain Homo sapiens 134-144 6216929-3 1983 At a concentration of apyrase that inhibited ADP-induced fibrinogen binding by greater than 85%, fibrinogen binding induced by collagen and arachidonic acid was only partially affected. Adenosine Diphosphate 45-48 fibrinogen beta chain Homo sapiens 57-67 6401213-3 1983 In response to both thrombin and A23187, the amounts of secretable ATP and ADP were strongly correlated in the platelets of individual patients; in contrast, secretable calcium showed no correlation with the nucleotides, and significant amounts of calcium were secreted in the total absence of nucleotide secretion in the platelets of several patients. Adenosine Diphosphate 75-78 coagulation factor II, thrombin Homo sapiens 20-28 6213262-5 1982 The temperature dependence of the chemical shift clearly indicates two limiting states for the S-1-CF3 with a highly temperature-dependent equilibrium between 5 and 40 degrees C. The low-temperature state appears to be identical with the state resulting from the binding of Mg.ADP or Mg.AMPPNP at 25 degree C. The energetics of the conformational change have been studied under various conditions. Adenosine Diphosphate 277-280 proteasome 26S subunit, non-ATPase 1 Homo sapiens 95-102 6579719-9 1983 The presence of fibrinogen is essential for platelet aggregation induced by adenosine diphosphate and for the observed changes in platelet surface charge. Adenosine Diphosphate 76-97 fibrinogen beta chain Homo sapiens 16-26 6813995-2 1982 Aggregation to collagen, calcium ionophore A23187 and thrombin (low doses) were often markedly inhibited by ethanol, adrenaline and ADP responses were little affected, and aggregation to exogenous arachidonic acid was actually potentiated by ethanol. Adenosine Diphosphate 132-135 coagulation factor II, thrombin Homo sapiens 54-62 6419355-0 1983 [Multimeric structure of factor VIII/von Willebrand factor released from human platelets by ADP, collagen and thrombin]. Adenosine Diphosphate 92-95 von Willebrand factor Homo sapiens 37-58 6753382-8 1982 In vitro, SIN1, a metabolite of molsidomin generated in the liver, led to a dose-dependent inhibition of ADP-induced platelet aggregation, whereas molsidomin was nearly inactive. Adenosine Diphosphate 105-108 MAPK associated protein 1 Homo sapiens 10-14 6811295-3 1982 Malondialdehyde formation, aggregation and [14C]serotonin release caused by threshold doses of thrombin were reduced but not abolished by 100 muM vinblastine; 30-100 muM vinblastine abolished ADP- and PGAP-induced malondialdehyde formation and [14C]serotonin released and transformed ADP- and PGAP-induced irreversible aggregation to a diminished reversible response. Adenosine Diphosphate 192-195 coagulation factor II, thrombin Homo sapiens 95-103 6811295-3 1982 Malondialdehyde formation, aggregation and [14C]serotonin release caused by threshold doses of thrombin were reduced but not abolished by 100 muM vinblastine; 30-100 muM vinblastine abolished ADP- and PGAP-induced malondialdehyde formation and [14C]serotonin released and transformed ADP- and PGAP-induced irreversible aggregation to a diminished reversible response. Adenosine Diphosphate 284-287 coagulation factor II, thrombin Homo sapiens 95-103 6281653-0 1982 Adenosine diphosphate induces binding of von Willebrand factor to human platelets. Adenosine Diphosphate 0-21 von Willebrand factor Homo sapiens 41-62 6282365-4 1982 As indicated by Scatchard analysis, receptors exposed by both epinephrine and ADP had similar affinities for fibrinogen, but epinephrine induced approximately 30% fewer receptors than did ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 109-119 6282365-6 1982 Studies using phentolamine, a specific alpha-adrenergic antagonist, apyrase, or creatine phosphate/creatine kinase indicate that the exposure of platelet fibrinogen receptors by epinephrine was specific for platelet alpha-adrenergic receptor stimulation and was not the result of released ADP. Adenosine Diphosphate 289-292 fibrinogen beta chain Homo sapiens 154-164 6954514-8 1982 Fibrinogen-dependent aggregation of washed platelets by ADP was abolished by a 30-fold molar excess of the peptide. Adenosine Diphosphate 56-59 fibrinogen beta chain Homo sapiens 0-10 7040594-7 1982 The enzyme enhanced luminescence immunoassay uses a pyruvate kinase labelled transferrin as tracer, which, after the antibody-antigen reaction and subsequent bound-free separation, is used to generate adenosine triphosphate (ATP) from adenosine diphosphate(ADP) and phosphoenol pyruvate. Adenosine Diphosphate 235-256 transferrin Homo sapiens 77-88 6281794-6 1982 Monospecific antibody fragments against the gamma chain inhibited binding of 125I-labeled fibrinogen to the human platelet receptor and blocked aggregation of platelets induced by ADP in the presence of fibrinogen or gamma-chain multimers. Adenosine Diphosphate 180-183 fibrinogen beta chain Homo sapiens 90-100 6281794-6 1982 Monospecific antibody fragments against the gamma chain inhibited binding of 125I-labeled fibrinogen to the human platelet receptor and blocked aggregation of platelets induced by ADP in the presence of fibrinogen or gamma-chain multimers. Adenosine Diphosphate 180-183 fibrinogen beta chain Homo sapiens 203-213 7040594-7 1982 The enzyme enhanced luminescence immunoassay uses a pyruvate kinase labelled transferrin as tracer, which, after the antibody-antigen reaction and subsequent bound-free separation, is used to generate adenosine triphosphate (ATP) from adenosine diphosphate(ADP) and phosphoenol pyruvate. Adenosine Diphosphate 257-260 transferrin Homo sapiens 77-88 6274453-1 1982 Fibrinogen binds to specific receptors on human washed platelets and these sites are induced by adenosine diphosphate (ADP). Adenosine Diphosphate 96-117 fibrinogen beta chain Homo sapiens 0-10 6133331-4 1982 Although both high concentrations of ADP and Pi inhibited the enzyme activities, Mg2+ ATPase was more sensitive to ADP and less sensitive to Pi in comparison to Ca2+ ATPase. Adenosine Diphosphate 37-40 carbonic anhydrase 2 Rattus norvegicus 161-172 6804991-3 1982 When PRP was incubated with arachidonic acid for 2 or 6 min before the addition of ADP, the ADP-induced aggregation was greatly decreased. Adenosine Diphosphate 83-86 prion protein Homo sapiens 5-8 6804991-3 1982 When PRP was incubated with arachidonic acid for 2 or 6 min before the addition of ADP, the ADP-induced aggregation was greatly decreased. Adenosine Diphosphate 92-95 prion protein Homo sapiens 5-8 6274453-1 1982 Fibrinogen binds to specific receptors on human washed platelets and these sites are induced by adenosine diphosphate (ADP). Adenosine Diphosphate 119-122 fibrinogen beta chain Homo sapiens 0-10 6274453-4 1982 In either citrated or heparinized PRP, association of fibrinogen with platelets was demonstrable and was dependent on ADP dose. Adenosine Diphosphate 118-121 fibrinogen beta chain Homo sapiens 54-64 6274453-11 1982 These results are similar to those obtained with washed platelets and establish that the previously defined steps in ADP-induced binding of fibrinogen to platelets occur in plasma, namely receptor induction by ADP, initial reversible binding, and irreversible binding. Adenosine Diphosphate 117-120 fibrinogen beta chain Homo sapiens 140-150 6274453-11 1982 These results are similar to those obtained with washed platelets and establish that the previously defined steps in ADP-induced binding of fibrinogen to platelets occur in plasma, namely receptor induction by ADP, initial reversible binding, and irreversible binding. Adenosine Diphosphate 210-213 fibrinogen beta chain Homo sapiens 140-150 6271255-1 1981 We have studied iron transfer from transferrin to ferritin in the presence of ATP, GTP, ADP, AMP and 2,3-diphosphoglycerate. Adenosine Diphosphate 88-91 transferrin Homo sapiens 35-46 7056562-1 1982 We previously reported that C-reactive protein (CRP), an acute phase reactant, inhibits platelet activation through an effect upon a factor(s) critical to ADP-mediated secondary wave platelet aggregation but independent of a direct effect upon platelet contractile elements. Adenosine Diphosphate 155-158 C-reactive protein Homo sapiens 28-46 7056562-1 1982 We previously reported that C-reactive protein (CRP), an acute phase reactant, inhibits platelet activation through an effect upon a factor(s) critical to ADP-mediated secondary wave platelet aggregation but independent of a direct effect upon platelet contractile elements. Adenosine Diphosphate 155-158 C-reactive protein Homo sapiens 48-51 7258729-3 1981 We found that 2 muM of ADP, and 9.1 and 22.7 muM of adrenalin induced statistically significant increases in nondissociative patterns of platelet aggregation in the patient group. Adenosine Diphosphate 23-26 latexin Homo sapiens 16-19 7272509-3 1981 With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4. Adenosine Diphosphate 17-20 fibrinogen beta chain Homo sapiens 93-103 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 49-52 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 173-183 7272509-7 1981 The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release. Adenosine Diphosphate 241-244 fibrinogen beta chain Homo sapiens 173-183 6797089-4 1981 125I-fibrinogen binding was measured in suspensions of freshly-washed normal platelets stimulated by 10 microM ADP or 10 microM adrenaline. Adenosine Diphosphate 111-114 fibrinogen beta chain Homo sapiens 5-15 6273393-0 1981 Histone-dependent ADP-ribosylation of low molecular nucleotide by poly(ADP-ribose) polymerase. Adenosine Diphosphate 18-21 poly(ADP-ribose) polymerase 1 Homo sapiens 66-93 6797089-7 1981 The mean % inhibition of ADP-induced fibrinogen binding was 82, 73, 42 and 32 respectively. Adenosine Diphosphate 25-28 fibrinogen beta chain Homo sapiens 37-47 7258729-4 1981 Maximum aggregation was significantly increased in the patient group compared with the controls by the addition of ADP (2 and 4 muM) or adrenalin (9.1 and 22.7 muM). Adenosine Diphosphate 115-118 latexin Homo sapiens 128-131 7258729-4 1981 Maximum aggregation was significantly increased in the patient group compared with the controls by the addition of ADP (2 and 4 muM) or adrenalin (9.1 and 22.7 muM). Adenosine Diphosphate 115-118 latexin Homo sapiens 160-163 6268723-2 1981 Inactivation of cholesterol 7 alpha-hydroxylase showed specific requirements of ATP and ADP. Adenosine Diphosphate 88-91 cytochrome P450 family 7 subfamily A member 1 Rattus norvegicus 16-47 7281105-5 1981 Mepacrine inhibited ADP-induced platelet aggregation by inhibiting the association of fibrinogen with platelets during aggregation. Adenosine Diphosphate 20-23 fibrinogen beta chain Homo sapiens 86-96 7292476-0 1981 Activation by ADP of dopamine beta-hydroxylase in bovine adrenal medulla. Adenosine Diphosphate 14-17 dopamine beta-hydroxylase Bos taurus 21-46 6789496-2 1981 ADP-induced 14C-5HT secretion in heparin-PRP and hirudin-PRP was generally decreased, relative to that in citrate-PRP, without corresponding reductions in aggregation, whereas in response to epinephrine, both aggregation and secretion were decreased in heparin-PRP, and abolished in hirudin-PRP. Adenosine Diphosphate 0-3 prion protein Homo sapiens 41-44 6789496-2 1981 ADP-induced 14C-5HT secretion in heparin-PRP and hirudin-PRP was generally decreased, relative to that in citrate-PRP, without corresponding reductions in aggregation, whereas in response to epinephrine, both aggregation and secretion were decreased in heparin-PRP, and abolished in hirudin-PRP. Adenosine Diphosphate 0-3 prion protein Homo sapiens 57-60 6789496-2 1981 ADP-induced 14C-5HT secretion in heparin-PRP and hirudin-PRP was generally decreased, relative to that in citrate-PRP, without corresponding reductions in aggregation, whereas in response to epinephrine, both aggregation and secretion were decreased in heparin-PRP, and abolished in hirudin-PRP. Adenosine Diphosphate 0-3 prion protein Homo sapiens 57-60 7256695-2 1981 Incubation of PRP with 4 to 16 micrograms/ml of HMW-GP results in inhibition of ADP-, Epinephrine-, Collagen-, and Thrombin-induced platelet aggregation. Adenosine Diphosphate 80-83 prion protein Homo sapiens 14-17 6789496-2 1981 ADP-induced 14C-5HT secretion in heparin-PRP and hirudin-PRP was generally decreased, relative to that in citrate-PRP, without corresponding reductions in aggregation, whereas in response to epinephrine, both aggregation and secretion were decreased in heparin-PRP, and abolished in hirudin-PRP. Adenosine Diphosphate 0-3 prion protein Homo sapiens 57-60 6789496-2 1981 ADP-induced 14C-5HT secretion in heparin-PRP and hirudin-PRP was generally decreased, relative to that in citrate-PRP, without corresponding reductions in aggregation, whereas in response to epinephrine, both aggregation and secretion were decreased in heparin-PRP, and abolished in hirudin-PRP. Adenosine Diphosphate 0-3 prion protein Homo sapiens 57-60 7030749-5 1981 In patients treated with alprenolol, the pre-exercise threshold level of ADP, producing platelet aggregation was 3.3 muM (geometric mean) and 5.1 muM after stopping treatment (p less than or equal to 0.05). Adenosine Diphosphate 73-76 latexin Homo sapiens 117-120 6454449-4 1981 This fraction of SPC is capable of recovering the coupling of oxidative phosphorylation of mitochondria whose respiration is inhibited by adding ADP. Adenosine Diphosphate 145-148 surfactant protein C Rattus norvegicus 17-20 7030749-6 1981 In patients receiving the beta-blocker, the ADP- threshold value dropped from 3.3 muM before exercise to 2.3 muM immediately after exercise (not significant). Adenosine Diphosphate 44-47 latexin Homo sapiens 109-112 7452090-4 1981 For example, low doses of ADP (0.1 to 0.7 microM) are added to stirred PRP, after which gentle centrifugation is used to remove aggregates from single unreacted platelets. Adenosine Diphosphate 26-29 prion protein Homo sapiens 71-74 6269776-3 1981 Exposure of cultured neuroblastoma cells to LPS produced rapid changes in the regulatory parameters of energy metabolism, an oxidation of intramitochondrial pyridine nucleotides, and a decline in cellular [ATP]/[ADP] [Pi], which were followed by alterations in mitochondrial morphology. Adenosine Diphosphate 212-215 toll-like receptor 4 Mus musculus 44-47 7274780-5 1981 Also in the presence of indomethacin (90 muM) Haemaccel inhibited aggregation induced by high concentrations of collagen and the primary aggregation induced by ADP and adrenaline, while Plasmion enhanced these aggregations induced by ADP and adrenaline, while Plasmion enhanced these aggregations. Adenosine Diphosphate 160-163 latexin Homo sapiens 41-44 7030749-5 1981 In patients treated with alprenolol, the pre-exercise threshold level of ADP, producing platelet aggregation was 3.3 muM (geometric mean) and 5.1 muM after stopping treatment (p less than or equal to 0.05). Adenosine Diphosphate 73-76 latexin Homo sapiens 146-149 7030749-6 1981 In patients receiving the beta-blocker, the ADP- threshold value dropped from 3.3 muM before exercise to 2.3 muM immediately after exercise (not significant). Adenosine Diphosphate 44-47 latexin Homo sapiens 82-85 7034150-10 1981 In conclusion, it is conceivable that the insulin-induced correction of poor erythrocyte deformability eliminates excessive fragility of erythrocytes and their haemolysis wit release of ADP, thus avoiding platelet hyperaggregation. Adenosine Diphosphate 186-189 insulin Homo sapiens 42-49 6118133-3 1980 Some 80% of this PPi is secreted by platelets treated with thrombin with a time course and dose-response relationship similar to secretion of ATP, ADP and 5-hydroxytryptamine (serotonin) from the platelet dense granules. Adenosine Diphosphate 147-150 coagulation factor II, thrombin Homo sapiens 59-67 6781096-3 1980 In normal PRP diluted with buffered EDTA, ADP induces an increase in turbidity without further changes in optical density. Adenosine Diphosphate 42-45 prion protein Homo sapiens 10-13 6253495-6 1980 With 4 microM epinephrine, more fibrinogen bound per platelet at all ADP doses than with ADP alone. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 32-42 6253495-8 1980 The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600). Adenosine Diphosphate 257-260 fibrinogen beta chain Homo sapiens 120-130 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 39-49 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 32-35 fibrinogen beta chain Homo sapiens 273-283 6253495-9 1980 The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet. Adenosine Diphosphate 135-138 fibrinogen beta chain Homo sapiens 39-49 7209886-0 1980 Identical behavior of fibrinogen and asialo-fibrinogen in reactions with platelets during ADP-induced aggregation. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 22-32 7209886-0 1980 Identical behavior of fibrinogen and asialo-fibrinogen in reactions with platelets during ADP-induced aggregation. Adenosine Diphosphate 90-93 fibrinogen beta chain Homo sapiens 44-54 6253495-0 1980 Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP. Adenosine Diphosphate 110-113 fibrinogen beta chain Homo sapiens 17-27 6253495-1 1980 The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. Adenosine Diphosphate 82-85 fibrinogen beta chain Homo sapiens 112-122 6253495-5 1980 The combination of low dose epinephrine (5 microM) and low dose ADP (0.5 microM), which acted synergistically to induce platelet aggregation, supported the rapid (10 min) binding of fibrinogen to platelets. Adenosine Diphosphate 64-67 fibrinogen beta chain Homo sapiens 182-192 6256088-1 1980 The rate of rat platelet shape change increases sigmoidally with respect to thrombin concentration under conditions where free Ca++ and ADP are limited to prevent platelet aggregation. Adenosine Diphosphate 136-139 coagulation factor II Rattus norvegicus 76-84 7426668-5 1980 Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP. Adenosine Diphosphate 141-144 hexokinase 1 Homo sapiens 93-103 7466752-0 1980 Effect of fibrinogen on ADP-induced platelet aggregation. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 10-20 7426668-5 1980 Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP. Adenosine Diphosphate 141-144 hexokinase 1 Homo sapiens 187-197 7426668-5 1980 Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP. Adenosine Diphosphate 338-341 hexokinase 1 Homo sapiens 187-197 7426668-6 1980 The reaction products from ADP and glucose, Glc-6-P and AMP, were identified by chromatography on ion-exchange resin column and paper. Adenosine Diphosphate 27-30 adenine phosphoribosyltransferase Homo sapiens 44-59 6246102-13 1980 The data suggest that (a) MgATP2- is the true substrate of adenosine kinase, and both pH and [Mg2+] may regulate its activity; (b) the kinetic mechanisms of adenosine kinase is Ordered Bi Bi; and (c) adenosine kinase may be regulated by the concentrations of its products, AMP and ADP, but is relatively insensitive to other purine and pyrimidine nucleotides. Adenosine Diphosphate 281-284 adenosine kinase Homo sapiens 59-75 7407418-0 1980 Participation of ADP in the binding of fibrinogen to thrombin-stimulated platelets. Adenosine Diphosphate 17-20 coagulation factor II, thrombin Homo sapiens 53-61 7407418-3 1980 Enzymatic removal of ADP with apyrase or creatine phosphate/creatine phosphokinase (CP/CPK) from thrombin-stimulated platelets markedly inhibited 125I-fibrinogen binding, but pretreatment of platelets with CP/CPK prior to thrombin stimulation was without effect. Adenosine Diphosphate 21-24 coagulation factor II, thrombin Homo sapiens 97-105 7407418-3 1980 Enzymatic removal of ADP with apyrase or creatine phosphate/creatine phosphokinase (CP/CPK) from thrombin-stimulated platelets markedly inhibited 125I-fibrinogen binding, but pretreatment of platelets with CP/CPK prior to thrombin stimulation was without effect. Adenosine Diphosphate 21-24 coagulation factor II, thrombin Homo sapiens 222-230 7407418-4 1980 Thus, ADP, released from the platelet, participates in the binding of fibrinogen to thrombin-stimulated platelets. Adenosine Diphosphate 6-9 coagulation factor II, thrombin Homo sapiens 84-92 6251496-2 1980 This analogue relaxes bovine coronary artery (potency ratio to PGI2 = 0.17), inhibits human PRP aggregation induced by ADP (IC50 = 12.5 nM2), deaggregates platelet clumps in cat heparinized blood (ED50 = 10.4 microgram/kg) and raises cAMP content in human PRP, but is less potent than PGI2. Adenosine Diphosphate 119-122 prion protein Homo sapiens 92-95 6448081-1 1980 The uncontrollable substrate recirculation in the central futile cycle (FC) in the carbohydrate energy metabolism fructose-6-P (F6P) in equilibrium or formed from fructose-1,6-P2 (FBP), makes it impossible to maintain a stable level of ATP because of its wasteful expenditure in the cycle reactions which are equivalent to the ATPase reaction and also because of the diversion of FBP from glycolytic phosphorylation of ADP. Adenosine Diphosphate 419-422 ECB2 Homo sapiens 180-183 6246102-10 1980 Hyperbolic inhibition was observed during noncompetitive inhibition of adenosine kinase by AMP and ADP. Adenosine Diphosphate 99-102 adenosine kinase Homo sapiens 71-87 6246102-13 1980 The data suggest that (a) MgATP2- is the true substrate of adenosine kinase, and both pH and [Mg2+] may regulate its activity; (b) the kinetic mechanisms of adenosine kinase is Ordered Bi Bi; and (c) adenosine kinase may be regulated by the concentrations of its products, AMP and ADP, but is relatively insensitive to other purine and pyrimidine nucleotides. Adenosine Diphosphate 281-284 adenosine kinase Homo sapiens 157-173 6246102-13 1980 The data suggest that (a) MgATP2- is the true substrate of adenosine kinase, and both pH and [Mg2+] may regulate its activity; (b) the kinetic mechanisms of adenosine kinase is Ordered Bi Bi; and (c) adenosine kinase may be regulated by the concentrations of its products, AMP and ADP, but is relatively insensitive to other purine and pyrimidine nucleotides. Adenosine Diphosphate 281-284 adenosine kinase Homo sapiens 157-173 7350149-0 1980 Interaction of fibrinogen with its platelet receptor as part of a multistep reaction in ADP-induced platelet aggregation. Adenosine Diphosphate 88-91 fibrinogen beta chain Homo sapiens 15-25 7381294-3 1980 It was shown for the first time in native nonanticoagulated PRP that prothrombin and factor V consumption by functional assays depends on physiologically active platelets, since inhibition by PGE and theophylline or by dibutyryl cyclic AMP and acceleration by ADP was observed. Adenosine Diphosphate 260-263 coagulation factor II, thrombin Homo sapiens 69-80 6246928-0 1980 Effect of adenosine 5"-triphosphate and adenosine 5"-diphosphate on the oxidation of cytochrome c by cytochrome c oxidase. Adenosine Diphosphate 40-64 cytochrome c, somatic Homo sapiens 101-113 6246928-1 1980 Adenosine 5"-triphosphate (ATP), adenosine 5"-diphosphate (ADP), and inorganic pyrophosphate partially inhibit the oxidation of exogenous cytochrome c by cytochrome c oxidase of submitochondrial particles (with or without detergent treatment) or by a purified preparation when it is assayed polarographically in buffers of nonbinding ions at pH 7.8. Adenosine Diphosphate 33-57 cytochrome c, somatic Homo sapiens 138-150 6246928-1 1980 Adenosine 5"-triphosphate (ATP), adenosine 5"-diphosphate (ADP), and inorganic pyrophosphate partially inhibit the oxidation of exogenous cytochrome c by cytochrome c oxidase of submitochondrial particles (with or without detergent treatment) or by a purified preparation when it is assayed polarographically in buffers of nonbinding ions at pH 7.8. Adenosine Diphosphate 33-57 cytochrome c, somatic Homo sapiens 154-166 6246928-1 1980 Adenosine 5"-triphosphate (ATP), adenosine 5"-diphosphate (ADP), and inorganic pyrophosphate partially inhibit the oxidation of exogenous cytochrome c by cytochrome c oxidase of submitochondrial particles (with or without detergent treatment) or by a purified preparation when it is assayed polarographically in buffers of nonbinding ions at pH 7.8. Adenosine Diphosphate 59-62 cytochrome c, somatic Homo sapiens 138-150 6246928-1 1980 Adenosine 5"-triphosphate (ATP), adenosine 5"-diphosphate (ADP), and inorganic pyrophosphate partially inhibit the oxidation of exogenous cytochrome c by cytochrome c oxidase of submitochondrial particles (with or without detergent treatment) or by a purified preparation when it is assayed polarographically in buffers of nonbinding ions at pH 7.8. Adenosine Diphosphate 59-62 cytochrome c, somatic Homo sapiens 154-166 6246928-6 1980 The observations can be explained by binding of ATP, ADP, or pyrophosphate to cytochrome c so that the formation of an especially reactive combination of cytochrome c and cytochrome oxidase previously postulated [Smith, L., Davies, H. C., & Nava, M. E. (1979) Biochemistry 18, 3140] is prevented. Adenosine Diphosphate 53-56 cytochrome c, somatic Homo sapiens 78-90 6246928-6 1980 The observations can be explained by binding of ATP, ADP, or pyrophosphate to cytochrome c so that the formation of an especially reactive combination of cytochrome c and cytochrome oxidase previously postulated [Smith, L., Davies, H. C., & Nava, M. E. (1979) Biochemistry 18, 3140] is prevented. Adenosine Diphosphate 53-56 cytochrome c, somatic Homo sapiens 154-166 6985716-5 1980 Intact plasma fibrinogen is required for the aggregation of platelets induced by ADP, and endogenous platelet fibrinogen influences thrombin-induced aggregation. Adenosine Diphosphate 81-84 fibrinogen beta chain Homo sapiens 14-24 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 55-76 fibrinogen beta chain Homo sapiens 0-10 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 0-10 6767512-1 1980 Fibrinogen is essential for aggregating platelets with adenosine diphosphate (ADP) and was recently shown to bind to platelets stimulated with ADP. Adenosine Diphosphate 143-146 fibrinogen beta chain Homo sapiens 0-10 6767512-9 1980 Thus, ADP-induced binding of fibrinogen correlates with platelet aggregability. Adenosine Diphosphate 6-9 fibrinogen beta chain Homo sapiens 29-39 6246928-0 1980 Effect of adenosine 5"-triphosphate and adenosine 5"-diphosphate on the oxidation of cytochrome c by cytochrome c oxidase. Adenosine Diphosphate 40-64 cytochrome c, somatic Homo sapiens 85-97 7404479-0 1980 Relationship of ADP-induced fibrinogen binding to platelet shape change and aggregation elucidated by use of colchicine and cytochalasin B. Adenosine Diphosphate 16-19 fibrinogen beta chain Homo sapiens 28-38 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 152-162 7404479-1 1980 ADP causes human, aspirin-treated, gel-filtered platelets to change from their native discoid shape to spiny spheres with pseudopods, bind 125I-labeled fibrinogen, and aggregate if shaken with sufficient fibrinogen. Adenosine Diphosphate 0-3 fibrinogen beta chain Homo sapiens 204-214 7404479-2 1980 After destruction of the added ADP with the enzyme apyrase, the platelets revert to a disc shape and lose much of their bound fibrinogen. Adenosine Diphosphate 31-34 fibrinogen beta chain Homo sapiens 126-136 6247744-4 1980 Exogenously added EPA was capable of inhibiting PRP aggregation induced either by exogenous or endogenous (released by ADP or collagen) arachidonate. Adenosine Diphosphate 119-122 prion protein Homo sapiens 48-51 7000043-6 1980 After indomethacin, the increase in CBF and the inhibition of ADP-induced platelet aggregation produced by bradykinin was greatly attenuated. Adenosine Diphosphate 62-65 kininogen 1 Canis lupus familiaris 107-117 542929-2 1979 It was found that the concentration of ADP obtaining in human PRP at the onset of aggregation was not sufficient to account for that aggregation. Adenosine Diphosphate 39-42 prion protein Homo sapiens 62-65 542929-6 1979 Collagen caused aggregation in ADP-refractory PRP and in platelet suspensions unresponsive to 1 mM ADP. Adenosine Diphosphate 31-34 prion protein Homo sapiens 46-49 574143-2 1979 Platelet stimulation by ADP resulted in the rapid, reversible binding of fibrinogen to receptors on the platelet surface. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 73-83 497404-0 1979 Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. Adenosine Diphosphate 93-96 fibrinogen beta chain Homo sapiens 14-24 574143-3 1979 Fibrinogen binding increased as the concentration of ADP was increased from 0.1 to 2 microM, reaching a plateau at higher ADP concentrations. Adenosine Diphosphate 53-56 fibrinogen beta chain Homo sapiens 0-10 574143-3 1979 Fibrinogen binding increased as the concentration of ADP was increased from 0.1 to 2 microM, reaching a plateau at higher ADP concentrations. Adenosine Diphosphate 122-125 fibrinogen beta chain Homo sapiens 0-10 393296-8 1979 PRP obtained from normal subjects after the ingestion of aspirin exhibited only one wave of aggregation in response to ADP, adrenaline or collagen, PGI2, PGD2 and PGE1 were all powerful inhibitors of this single wave of aggregation. Adenosine Diphosphate 119-122 prion protein Homo sapiens 0-3 574143-7 1979 These fibrinogen binding parameters were essentially the same whether ADP or epinephrine was the platelet-stimulating agent. Adenosine Diphosphate 70-73 fibrinogen beta chain Homo sapiens 6-16 574143-8 1979 Thus, these studies demonstrate that platelet stimulation by ADP and epinephrine exposes a limited number of fibrinogen receptors on the platelet surface. Adenosine Diphosphate 61-64 fibrinogen beta chain Homo sapiens 109-119 421222-4 1979 Conversely, a large reduction in ADP ribosylation was seen in core histones (H2A, H2B, and H3) from the same nuclei. Adenosine Diphosphate 33-36 histone cluster 1, H2bg Rattus norvegicus 82-93 508292-8 1979 The metabolic inhibitors only affected (14)C-labelled nucleotides, whereas thrombin only liberated unlabelled ATP and ADP. Adenosine Diphosphate 118-121 coagulation factor II, thrombin Homo sapiens 75-83 444675-4 1979 Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 0-10 444675-4 1979 Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction. Adenosine Diphosphate 72-75 fibronectin 1 Homo sapiens 23-34 444675-4 1979 Fibrinogen depleted of fibronectin (less than 2 microgram/mg) supported ADP-induced aggregation as effectively as fibrinogen contaminated with this protein, thus reinforcing the generally held view that fibrinogen itself is the necessary protein cofactor in this reaction. Adenosine Diphosphate 72-75 fibrinogen beta chain Homo sapiens 203-213 218926-8 1979 These findings, together with the chemical properties of the linkage, which were typical of those of an ester-like bond, strongly suggest that the ADP-Rib residue was linked to the gamma-COOH group of the glutamic acid in position 2 of H2B. Adenosine Diphosphate 147-150 histone cluster 1, H2bg Rattus norvegicus 236-239 726089-3 1978 The ammonia production from ADP in the mitochondrial fraction is connected with the formation on ATP and AMP under the influence of myokinase and subsequent deamination of AMP by AMP-deaminase. Adenosine Diphosphate 28-31 adenylate kinase 1 Rattus norvegicus 132-141 160095-0 1979 The ability of fibrinogen fragments to support ADP-induced platelet aggregation. Adenosine Diphosphate 47-50 fibrinogen beta chain Homo sapiens 15-25 210972-2 1978 ECM incubated with lipoprotein-deficient plasma (LDP) for 2 hours at 37 degrees C had an inhibitory effect on ADP- and collagen-induced platelet aggregation and prostaglandin production in platelet-rich plasma similar to that observed when ECM were preincubated with growth medium or plasma. Adenosine Diphosphate 110-113 carboxypeptidase Q Homo sapiens 19-47 210972-2 1978 ECM incubated with lipoprotein-deficient plasma (LDP) for 2 hours at 37 degrees C had an inhibitory effect on ADP- and collagen-induced platelet aggregation and prostaglandin production in platelet-rich plasma similar to that observed when ECM were preincubated with growth medium or plasma. Adenosine Diphosphate 110-113 carboxypeptidase Q Homo sapiens 49-52 215408-6 1978 The activities of the ADP derivatives, V, VIII, X, XIII, dextran-bound VIII, and dextran-bound XIII against acetate kinase were 82%, 81%, 68%, 55%, 35%, and 15%, respectively, relative to ADP and those of the ATP derivatives, VI, IX, XI, XIV, dextran-bound IX, and dextran-bound XIV against hexokinase were 88%, 94%, 60%, 81%, 58%, and 49%, respectively, relative to ATP. Adenosine Diphosphate 22-25 hexokinase 1 Homo sapiens 291-301 681825-3 1978 With varying concentrations of ADP preincubated with PRP initially containing essentially disc-shaped platelets, it was found that induced shape change in the absence of an aggregation is necessary and sufficient for the development of PCA. Adenosine Diphosphate 31-34 prion protein Homo sapiens 53-56 658786-3 1978 Addition of human fibrinogen to the Tyrode-suspending buffer was required for ADP and epinephrine, but was not necessary for trypsin or collagen. Adenosine Diphosphate 78-81 fibrinogen beta chain Homo sapiens 18-28 207296-6 1978 Adenosine kinase from liver and hepatoma 3924A was inhibited by the reaction products ADP and AMP, and the enzyme was also subject to excess substrate inhibition by concentrations of ATP in excess of 1 mM. Adenosine Diphosphate 86-89 adenosine kinase Rattus norvegicus 0-16 579700-8 1977 Upon aggregation with thrombin, approximately 50% of ADP and 40% ATP is releaseed. Adenosine Diphosphate 53-56 coagulation factor II, thrombin Homo sapiens 22-30 603637-1 1977 31P nuclear-magnetic-resonance spectra of MgADP bound to creatine kinase in the presence of creatine NO3- ions show that there are two non-identical forms of the bound nucleotide. Adenosine Diphosphate 42-47 NBL1, DAN family BMP antagonist Homo sapiens 101-104 610662-0 1977 [Treatment of ADP responsive diabetes insipidus in children with DDAVP (1-desamino-8-D-arginine-vasopressin)]. Adenosine Diphosphate 14-17 arginine vasopressin Homo sapiens 96-107 72575-1 1977 The ADP- and collagen-induced aggregation of platelets in PRP of healthy probands was tested in vitro in the presence of 4 heparin preparations (Novo, Vitrum, Liquemin, Haemoderivate) and of a heparinoid (Eleparon). Adenosine Diphosphate 4-7 prion protein Homo sapiens 58-61 196856-3 1977 Coenzymic activities of the ADP analogue against acetate kinase and pyruvate kinase were 82% and 20%, respectively, relative to ADP and those of the ATP analogue against hexokinase and glycerokinase were 63% and 87%, respectively, relative to ATP. Adenosine Diphosphate 28-31 hexokinase 1 Homo sapiens 170-180 70475-4 1977 Multiple considerations including selective inhibition of secondary wave aggregation suggested that CRP exerted its inhibitory effects by interfering with the release of endogenous ADP. Adenosine Diphosphate 181-184 C-reactive protein Homo sapiens 100-103 70475-5 1977 In the present investigation, CRP was found by direct assay to inhibit the release of endogenous ADP and/or serotonin concomitant with inhibition of platelet aggregation stimulated by ADP, epinephrine, thrombin, and AHGG. Adenosine Diphosphate 97-100 C-reactive protein Homo sapiens 30-33 70475-5 1977 In the present investigation, CRP was found by direct assay to inhibit the release of endogenous ADP and/or serotonin concomitant with inhibition of platelet aggregation stimulated by ADP, epinephrine, thrombin, and AHGG. Adenosine Diphosphate 184-187 C-reactive protein Homo sapiens 30-33 303176-7 1977 Ca2+ stimulated the reduction of cytochrome P-450 by NADPH and this was inhibited by ADP. Adenosine Diphosphate 54-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-49 303176-13 1977 These data have been interpreted to indicate that Ca2+ and ADP influence the relationship between adrenodoxin and cytochrome P-450 so that a complex of increased activity in the reduction of cytochrome P-450 is formed in the presence of Ca2+ and a less active complex is formed in the presence of Ca2+ plus ADP. Adenosine Diphosphate 59-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 114-130 303176-13 1977 These data have been interpreted to indicate that Ca2+ and ADP influence the relationship between adrenodoxin and cytochrome P-450 so that a complex of increased activity in the reduction of cytochrome P-450 is formed in the presence of Ca2+ and a less active complex is formed in the presence of Ca2+ plus ADP. Adenosine Diphosphate 59-62 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 191-207 303176-13 1977 These data have been interpreted to indicate that Ca2+ and ADP influence the relationship between adrenodoxin and cytochrome P-450 so that a complex of increased activity in the reduction of cytochrome P-450 is formed in the presence of Ca2+ and a less active complex is formed in the presence of Ca2+ plus ADP. Adenosine Diphosphate 307-310 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 114-130 303176-13 1977 These data have been interpreted to indicate that Ca2+ and ADP influence the relationship between adrenodoxin and cytochrome P-450 so that a complex of increased activity in the reduction of cytochrome P-450 is formed in the presence of Ca2+ and a less active complex is formed in the presence of Ca2+ plus ADP. Adenosine Diphosphate 307-310 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 191-207 909782-1 1977 Hexokinase (EC 2.7.1.1) will convert commercially available alpha-[(32)P]-labelled ATP into alpha-[(32)P]-labelled ADP. Adenosine Diphosphate 115-118 hexokinase 1 Homo sapiens 0-10 19087-4 1977 GTP, 2,3-diphosphoglycerate, ATP, ADP and citrate produced the most rapid exchange of iron between the two types of transferrin, but many other compounds showed some degree of activity. Adenosine Diphosphate 34-37 transferrin Homo sapiens 116-127 195584-13 1977 In the presence of oligomycin and ADP, oxidation of pyruvate, but not of glycerol 3-phosphate, supported a greater protonmotive force than in State 4, in keeping with the dehydrogenase activation and increased redox span NAD-cytochrome c found under these conditions. Adenosine Diphosphate 34-37 cytochrome c, somatic Homo sapiens 225-237 190100-9 1977 Thrombin-induced synthesis of PGE is inhibited by ADP. Adenosine Diphosphate 50-53 coagulation factor II, thrombin Homo sapiens 0-8 327607-1 1977 We have shown previously that washed human platelets resuspended in Tyrode solution containing albumin and apyrase maintain their disc shape and their ability to aggregate upon the addition of low concentration of ADP, providing fibrinogen is added to the suspending medium. Adenosine Diphosphate 214-217 fibrinogen beta chain Homo sapiens 229-239 327607-8 1977 Responses to collagen or thrombin were greater in a modified medium containing magnesium but no calcium; in this medium, aggregation caused by ADP or polylysine was followed by the release of granule contents whereas these agents caused aggregation without release in a medium with both calcium and magnesium. Adenosine Diphosphate 143-146 coagulation factor II, thrombin Homo sapiens 25-33 843621-0 1977 Significance of the intact polypeptide chains of human fibrinogen in ADP-induced platelet aggregation. Adenosine Diphosphate 69-72 fibrinogen beta chain Homo sapiens 55-65 843621-1 1977 The presence of human fibrinogen in suspensions of washed human platelets is a requirement for ADP-induced platelet aggregation. Adenosine Diphosphate 95-98 fibrinogen beta chain Homo sapiens 22-32 843621-3 1977 The high solubility fraction of Kabi fibrinogen, fragment X (stage 1) and framgent X (stage 2), are two, eight, and ten times, respectively, less potent in promoting ADP-induced platelet aggregation, as compared with intact fibrinogen. Adenosine Diphosphate 166-169 fibrinogen beta chain Homo sapiens 37-47 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 65-75 843621-5 1977 SDS polyacrylamide gel electrophoresis of nonreduced and reduced fibrinogen and its derivatives indicates that the intact fibrinogen molecule is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 159-162 fibrinogen beta chain Homo sapiens 122-132 863293-2 1977 We found, for example, that this degree of aggregation could be elicited in adult PRP by a mean value of 2.09 micronM ADP, whereas similar aggregation of neonatal PRP required 5.16 micronM ADP. Adenosine Diphosphate 118-121 prion protein Homo sapiens 82-85 844904-8 1977 The platelet-aggregating substances collagen, arachidonic acid, and adenosine 5"-diphosphate caused beta-lysin to be released from PRP. Adenosine Diphosphate 68-92 complement component 4 binding protein alpha Homo sapiens 131-134 863293-2 1977 We found, for example, that this degree of aggregation could be elicited in adult PRP by a mean value of 2.09 micronM ADP, whereas similar aggregation of neonatal PRP required 5.16 micronM ADP. Adenosine Diphosphate 189-192 prion protein Homo sapiens 163-166 863293-3 1977 Based on these figures, we observed that adult PRP was about 2.5 times more sensitive to ADP, at least 10 times to epinephrine and 2.3 times to collagen than neonatal PRP. Adenosine Diphosphate 89-92 prion protein Homo sapiens 47-50 10970-7 1976 The rates of rephosphorylation of metabolic ADP to ATP via glycolysis and oxidative phosphorylation were estimated by measuring lactate production and O2 consumption in resting and thrombin-stimulated platelets and compared to the level of metabolic ATP (9-10 nmol/mg of platelet protein in the resting state). Adenosine Diphosphate 44-47 coagulation factor II, thrombin Homo sapiens 181-189 1003872-2 1976 When incubating platelet-rich plasma with insulin and glucose simultaneously, a marked inhibition of the ADP- or collagen-induced platelet aggregation and release reaction results. Adenosine Diphosphate 105-108 insulin Homo sapiens 42-49 1016916-5 1976 Allopurinol ribonucleotide, ADP, or ATP were competitive inhititors when AMP was the substrate, with a Ki slope of 120 muM. Adenosine Diphosphate 28-31 latexin Homo sapiens 119-122 987797-6 1976 The low concentration of bovine factor VIII induces moderate retraction of reptilase-clotted platelet-clotted platelet-rich plasma, which is inhibited by acetylsalicylic acid, indomethacin and apyrase, indicating that it is a consequence of release of platelet adenosine-5"-diphosphate. Adenosine Diphosphate 261-285 coagulation factor VIII Bos taurus 32-43 971436-7 1976 Concanavalin A inhibited the ADP-induced aggregation of platelets suspended in plasma or in a salts solution supplemented with calcium and fibrinogen, although the inhibitory effect was more conspicuous in the latter case. Adenosine Diphosphate 29-32 fibrinogen beta chain Homo sapiens 139-149 178342-8 1976 When cAMP had been increased by adenosine, PGE1 or RA233, the addition of ADP caused cAMP to decrease rapidly in both human and rat platelets to between +22 and -18% of control values, except that the decrease in rat platelets was to +40% after RA233 had been present for 0.5 min before ADP. Adenosine Diphosphate 74-77 cathelicidin antimicrobial peptide Homo sapiens 5-9 977942-10 1976 These experiments extend the platelet reactivities inhibited by CRP, show that CRP expresses its inhibitory capacity in platelet-rich plasma as well as upon isolated platelets, raise the possibility that CRP exercises its effects by inhibiting or interfering with the release and/or utilization of endogenous platelet ADP, and support the concept that CRP plays an important role in the control of platelet responsiveness to a variety of stimuli during acute inflammatory reactions. Adenosine Diphosphate 319-322 C-reactive protein Homo sapiens 80-83 977942-10 1976 These experiments extend the platelet reactivities inhibited by CRP, show that CRP expresses its inhibitory capacity in platelet-rich plasma as well as upon isolated platelets, raise the possibility that CRP exercises its effects by inhibiting or interfering with the release and/or utilization of endogenous platelet ADP, and support the concept that CRP plays an important role in the control of platelet responsiveness to a variety of stimuli during acute inflammatory reactions. Adenosine Diphosphate 319-322 C-reactive protein Homo sapiens 80-83 977942-10 1976 These experiments extend the platelet reactivities inhibited by CRP, show that CRP expresses its inhibitory capacity in platelet-rich plasma as well as upon isolated platelets, raise the possibility that CRP exercises its effects by inhibiting or interfering with the release and/or utilization of endogenous platelet ADP, and support the concept that CRP plays an important role in the control of platelet responsiveness to a variety of stimuli during acute inflammatory reactions. Adenosine Diphosphate 319-322 C-reactive protein Homo sapiens 80-83 10638-3 1976 Without fibrinogen, thrombin induced rapid release of platelet ADP but failed to cause second wave of LTI. Adenosine Diphosphate 63-66 coagulation factor II, thrombin Homo sapiens 20-28 10638-8 1976 The results suggest that the release of platelet ADP induced by thrombin primarily affects the first phase aggregation, and the second phase may result from interaction of thrombin-exposed platelets and polymerizing fibrin. Adenosine Diphosphate 49-52 coagulation factor II, thrombin Homo sapiens 64-72 10638-8 1976 The results suggest that the release of platelet ADP induced by thrombin primarily affects the first phase aggregation, and the second phase may result from interaction of thrombin-exposed platelets and polymerizing fibrin. Adenosine Diphosphate 49-52 coagulation factor II, thrombin Homo sapiens 172-180 1277585-2 1976 The incubation of the PBC patients" lymphocytes with isolated rat liver mitochondria produced a significant inhibition of mitochondrial respiration in the presence of ADP. Adenosine Diphosphate 167-170 dihydrolipoamide S-acetyltransferase Homo sapiens 22-25 977942-2 1976 Inhibition by CRP of platelet reactivities stimulated by poly-L-lysine, ADP, epinephrine, and collagen. Adenosine Diphosphate 72-75 C-reactive protein Homo sapiens 14-17 977942-7 1976 CRP similarly inhibited ADP- and epinephrine-stimulated platelet aggregation in platelet-rich plasma (PRP), and this was characterized by relatively minimal suppression of the primary wave of aggregation. Adenosine Diphosphate 24-27 C-reactive protein Homo sapiens 0-3 977942-7 1976 CRP similarly inhibited ADP- and epinephrine-stimulated platelet aggregation in platelet-rich plasma (PRP), and this was characterized by relatively minimal suppression of the primary wave of aggregation. Adenosine Diphosphate 24-27 complement component 4 binding protein alpha Homo sapiens 102-105 977942-9 1976 Finally, CRP inhibited the activation of PF3 and the release of serotonin during stimulation of platelets with ADP, and this inhibition was temporally related to the onset of the secondary wave of aggregation. Adenosine Diphosphate 112-115 C-reactive protein Homo sapiens 9-12 818909-0 1976 ADP-induced inhibition of von Willebrand factor-mediated platelet agglutination. Adenosine Diphosphate 0-3 von Willebrand factor Homo sapiens 26-47 818909-2 1976 The prior addition of 1-10 muM ADP, which causes platelet shape change but not aggregation under these conditions, inhibited vWF-mediated agglutination. Adenosine Diphosphate 31-34 latexin Homo sapiens 27-30 818909-2 1976 The prior addition of 1-10 muM ADP, which causes platelet shape change but not aggregation under these conditions, inhibited vWF-mediated agglutination. Adenosine Diphosphate 31-34 von Willebrand factor Homo sapiens 125-128 818909-4 1976 Addition of ADP caused prompt reversal of established vWF-mediated agglutination, which resumed when the ADP was enzymatically removed. Adenosine Diphosphate 12-15 von Willebrand factor Homo sapiens 54-57 818909-4 1976 Addition of ADP caused prompt reversal of established vWF-mediated agglutination, which resumed when the ADP was enzymatically removed. Adenosine Diphosphate 105-108 von Willebrand factor Homo sapiens 54-57 818909-10 1976 It concluded that ADP causes a reversible decrease in the accessibility of the membrane receptor to vWF. Adenosine Diphosphate 18-21 von Willebrand factor Homo sapiens 100-103 178342-8 1976 When cAMP had been increased by adenosine, PGE1 or RA233, the addition of ADP caused cAMP to decrease rapidly in both human and rat platelets to between +22 and -18% of control values, except that the decrease in rat platelets was to +40% after RA233 had been present for 0.5 min before ADP. Adenosine Diphosphate 74-77 cathelicidin antimicrobial peptide Homo sapiens 85-89 178342-8 1976 When cAMP had been increased by adenosine, PGE1 or RA233, the addition of ADP caused cAMP to decrease rapidly in both human and rat platelets to between +22 and -18% of control values, except that the decrease in rat platelets was to +40% after RA233 had been present for 0.5 min before ADP. Adenosine Diphosphate 287-290 cathelicidin antimicrobial peptide Homo sapiens 5-9 182140-14 1976 The inhibition of the utilization of limiting amounts of EF 2 on ADP-ribosylation is very likely the consequence of a concomitant decrease in the rate of association and dissociation of the enzyme from ribosomes. Adenosine Diphosphate 65-68 eukaryotic translation elongation factor 2 Rattus norvegicus 57-61 813326-2 1975 These studies demonstrate that the amount of human platelet ADP released and ATP catabolized increase with time of stirring of the collagen-platelet rich plasma (PRP) mixture and with increasing amounts of collagen. Adenosine Diphosphate 60-63 complement component 4 binding protein alpha Homo sapiens 131-160 818325-11 1976 Addition of thrombin (1 U. per milliliter) liberated all of the PF4 antigen (78 +/- 24 mug) present in PRP but ADP (50 muM) released only 31 +/- 22 mug of PF4 antigen per 10(9) platelets. Adenosine Diphosphate 111-114 latexin Homo sapiens 119-122 1278350-1 1976 The influence of four agents--pyrazolidinedione derivatives on the ADP-induced aggregation and activity of glycolytic enzymes--glyceraldehydrophosphate dehydrogenase and lactate dehydrogenase (GAPD, LDG) and of the anatomic oxidation enzyme--glucose-6-phosphate dehydrogenase (G-6-PD) was studied. Adenosine Diphosphate 67-70 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 193-197 139173-5 1976 MgATP and AMP are inefficient as specific eluents whereas ATP and ADP elute only a small part of PFK with concomitant substantial increase of the ionic strength (up to 0.17--0.18). Adenosine Diphosphate 66-69 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 97-100 939224-1 1976 Kinetic methods have been used to determine the interrelationship between HCO-3, pyruvate and acetyl-CoA and their effect on pigeon kidney pyruvate carboxylase (pyruvate: CO2 ligase [ADP], EC 6.4.1.1). Adenosine Diphosphate 183-186 pyruvate carboxylase Homo sapiens 139-159 172141-2 1975 ATP, ADP and pyrophosphate accelerate the exchange of carbonate of the transferrin-iron-carbonate ternary complex, while AMP, cyclic AMP and phosphate have no effect. Adenosine Diphosphate 5-8 transferrin Homo sapiens 71-82 813326-2 1975 These studies demonstrate that the amount of human platelet ADP released and ATP catabolized increase with time of stirring of the collagen-platelet rich plasma (PRP) mixture and with increasing amounts of collagen. Adenosine Diphosphate 60-63 complement component 4 binding protein alpha Homo sapiens 162-165 813326-5 1975 Stirring the collagen-PRP mixture maximized ADP release and ATP catabolism; some ADP release and ATP catabolism occurred with minimal agitation. Adenosine Diphosphate 44-47 complement component 4 binding protein alpha Homo sapiens 22-25 813326-6 1975 Incubation of PRP with metabolid poisons (2-deoxyglucose with either KCN or oligomycin), which lowered platelet ATP content, also reduced collagen-induced release of ADP and aggregation. Adenosine Diphosphate 166-169 complement component 4 binding protein alpha Homo sapiens 14-17 50744-3 1975 Conditions that caused release during ADP-inducedaggregation were-citrate as the anticoagulant in platelet-rich plasma; addition of citrate (11-15 mM) to a suspension of washed platelets, or to hirudin-plasma or heparin-plasma; suspension of platelets in a medium containing magnesium but no calcium;and the presence of trace amounts of thrombin or aggregated gamma globulin in the platelet suspensions. Adenosine Diphosphate 38-41 coagulation factor II, thrombin Homo sapiens 337-345 1211467-4 1975 Addition of ADP to the platelet-fibrinogen mixture prior to BM enzyme resulted in stimulation of clot retraction that could be dissociated from the release of platelet constituents. Adenosine Diphosphate 12-15 fibrinogen beta chain Homo sapiens 32-42 1211467-8 1975 It has been postulated that platelet-dependent fibrin clot retraction induced by collagen, epinephrine, and low concentration of thrombin is mediated by ADP. Adenosine Diphosphate 153-156 coagulation factor II, thrombin Homo sapiens 129-137 1081963-2 1975 Using gel filtration-isolated platelets, the ADP induced hyperaggregation previously reported in diabetics with severe retinopathy untreated by hypophysectomy appeared to be related to a platelet and not a plasma factor; the normal results of thrombin induced aggregation suggests that the presumed abnormal platelet factor is related to the platelet plasma membrane. Adenosine Diphosphate 45-48 coagulation factor II, thrombin Homo sapiens 243-251 809571-19 1975 Additional process, such as a modulation of the Ca2+ release by free [Mg2+] and [ADP] may help to explain the gradation of the contractions. Adenosine Diphosphate 81-84 carbonic anhydrase 2 Rattus norvegicus 48-51 1227639-5 1975 The observed differences in the character of aggregation coursing in the presence of factor XIIIa when different aggregating agents (ADP and thrombin) were used were apparently due to the interaction of active factor XIII with thrombin added to the plasma in the capacity of an aggregating agent. Adenosine Diphosphate 133-136 coagulation factor II Rattus norvegicus 227-235 167888-6 1975 It is concluded that adrenaline, thrombin, 5HT, and vasopressin each can induce primary aggregation of human platelets by a mechanism independent of extracellular ADP. Adenosine Diphosphate 163-166 arginine vasopressin Homo sapiens 52-63 811245-0 1975 The role of thrombin in ADP-induced platelet aggregation and release: a critical evaluation. Adenosine Diphosphate 24-27 coagulation factor II, thrombin Homo sapiens 12-20 811245-1 1975 The role of thrombin in ADP-induced aggregation and release in vitro was critically examined. Adenosine Diphosphate 24-27 coagulation factor II, thrombin Homo sapiens 12-20 50744-6 1975 Although fibrinogen is required for ADP-induced primary aggregation, it does not support secondary aggregation and release, provided that it has no clot-promoting activity. Adenosine Diphosphate 36-39 fibrinogen beta chain Homo sapiens 9-19 16659228-1 1975 Of a variety of purine and pyrimidine nucleotides tested, only ADP and 5"AMP significantly inhibited the Mg(2+)-dependent activity of pea leaf glutamine synthetase. Adenosine Diphosphate 63-66 glutamate-ammonia ligase Homo sapiens 143-163 1091638-2 1975 EF-2, purified 1,960-fold, appears to be active as a single polypeptide chain with a molecular weight of approximately 100,000 based upon the following determinations: sodium dodecyl sulfate gel electrophoresis (95,000); sedimentation equilibrium centrifugation (112,000); gel filtration (97,000); ADP-ribosylation (103,000). Adenosine Diphosphate 298-301 eukaryotic translation elongation factor 2 Rattus norvegicus 0-4 1140197-6 1975 The latter ATP analogue, when bound to Sepharose through its terminal amino group, could be dephosphorylated to the corresponding ADP analogue with soluble hexokinase yielding glucose 6-phosphate in an enzymic "solidphase" fashion. Adenosine Diphosphate 130-133 hexokinase 1 Homo sapiens 156-166 1138423-6 1975 Release of platelet ADP was found to be normal by collagen and thrombin, but impaired by kaolin. Adenosine Diphosphate 20-23 coagulation factor II, thrombin Homo sapiens 63-71 1193453-5 1975 These findings correlated well with those obtained with collagen, and indicate that bovine factor VIII induces the platelet release reaction whereby the storage (non-metabolic) pool of ATP and ADP is released while the metabolic pool is retained. Adenosine Diphosphate 193-196 coagulation factor VIII Bos taurus 91-102 239871-3 1975 2) The optimal condition of the binding reaction was for 100 minutes of reaction time at pH 4.0 and 4 degrees C. 3) The specificities of binding protein to the other nucleotides were 0 to adenosine, 0.4 to AMP, 0.3 to ADP, 0.4 to ATP and 0.6 to c-GMP respectively when the specificity to c-AMP was chosen as 100. Adenosine Diphosphate 218-221 cathelicidin antimicrobial peptide Homo sapiens 288-293 1112783-8 1975 Simultaneous binding studies using pyridoxal-5-P with known malate dehydrogenase competitive inhibitors AMP, ADP, and nicotinamide indicate that the pyridoxal-5-P modification occurs in the general area of the ADP portion of the coenzyme binging site. Adenosine Diphosphate 109-112 malic enzyme 2 Homo sapiens 60-80 1112783-8 1975 Simultaneous binding studies using pyridoxal-5-P with known malate dehydrogenase competitive inhibitors AMP, ADP, and nicotinamide indicate that the pyridoxal-5-P modification occurs in the general area of the ADP portion of the coenzyme binging site. Adenosine Diphosphate 210-213 malic enzyme 2 Homo sapiens 60-80 1096557-4 1975 Since the electron flux in the respiratory chain is controlled by the ADP supply, alcohol dehydrogenase-dependent ethanol metabolism can be activated by perturbations which circumvent the rate-limiting step, such as artificial electron acceptors, gluconeogenic precursors, and uncoupling agents. Adenosine Diphosphate 70-73 aldo-keto reductase family 1 member A1 Rattus norvegicus 82-103 1231964-2 1975 The response of platelet-rich plasma to 0.1, 1 and 10 muM of ADP and 1 and 10 muM of epinephrine were tested in a Chrono-Log aggregometer. Adenosine Diphosphate 61-64 latexin Homo sapiens 54-57 1231964-5 1975 In the group with coronary artery disease, the incidence of irreversible responses was significantly higher after exercise on test with 1 muM ADP (p less than 0.05), 1 muM epinephrine (p=0.02), and 10 muM epinephrine (p less than 0.05). Adenosine Diphosphate 142-145 latexin Homo sapiens 138-141 236182-1 1975 Kinetic methods have been used to determine whether Mg2+ and MgATP2- play an important role in regulating pigeon liver pyruvate carboxylase [pyruvate: CO2 ligase (ADP), EC 6.4.1.1]. Adenosine Diphosphate 163-166 pyruvate carboxylase Homo sapiens 119-139 807204-11 1975 Whereas very low concentrations of Ca-2+ inhibit ADP-stimulated respiration and oxidative phosphorylation in mitochondria from newly emerged flies (Ki approx. Adenosine Diphosphate 49-52 carbonic anhydrase 2 Rattus norvegicus 35-40 54319-1 1975 Bovine fibrinogen can aggregate human blood platelets by a direct mechanism (first wave) and also indirectly by releasing endogenous ADP (second wave). Adenosine Diphosphate 133-136 fibrinogen beta chain Homo sapiens 7-17 54319-5 1975 The changes induced by bovine fibrinogen thus follows the same pattern as the irreversible phase of aggregation, linked to release as induced by ADP. Adenosine Diphosphate 145-148 fibrinogen beta chain Homo sapiens 30-40 1105006-2 1975 Minute amounts of myokinase interfere with binding measurements, but by selection of appropriate conditions, we can estimate that the value of the apparent deltaHbinding lies between - 1.0 and - 3.0 kcal per mole of ADP bound (0.3 M KC1, 2 mM MgC12, 20mM Tris, pH 8.00, 20 degrees C). Adenosine Diphosphate 216-219 adenylate kinase 1 Homo sapiens 18-27 19396987-7 1974 (3) p-Chlorophenyl pyruvate, an inhibitor of pyruvate carboxylase (pyruvate: carbondioxide ligase, ADP, EC 6.4.1.1), also inhibited lactate production from pyruvate. Adenosine Diphosphate 99-102 pyruvate carboxylase Homo sapiens 45-65 806102-2 1975 Aggregation of human platelets by ADP, collagen and prostaglandin G2 was inhibited more strongly by PGD2 than by PGE1. Adenosine Diphosphate 34-37 prostaglandin D2 synthase Homo sapiens 100-104 806102-3 1975 Although ADP-induced aggregation of rabbit platelets was inhibited more strongly by PGE1 than by PGD2 the latter prostaglandin gave a more long-lasting inhibitory effect on platelet aggregation following intravenous or oral administration. Adenosine Diphosphate 9-12 prostaglandin D2 synthase Homo sapiens 97-101 4354325-4 1972 Pyruvate carboxylase activity was present in all insect flight muscles that were investigated: in homogenates of bumble-bee flight muscle the activity was inhibited by ADP and activated by acetyl-CoA, and it was distributed mainly in the mitochondrial fraction. Adenosine Diphosphate 168-171 pyruvate carboxylase Homo sapiens 0-20 4762259-0 1973 Enhancement by ADP of thrombin-induced aggregation in ADP-refractory platelets. Adenosine Diphosphate 15-18 coagulation factor II, thrombin Homo sapiens 22-30 4762259-0 1973 Enhancement by ADP of thrombin-induced aggregation in ADP-refractory platelets. Adenosine Diphosphate 54-57 coagulation factor II, thrombin Homo sapiens 22-30 4675006-23 1972 We conclude that ADP and adrenaline, like thrombin and collagen, cause extrusion of non-metabolic granula-located platelet adenine nucleotides. Adenosine Diphosphate 17-20 coagulation factor II, thrombin Homo sapiens 42-50 5060578-1 1972 A ferritin-conjugated anti-fibrin/fibrinogen was localized by means of light and electron microscopy in artificial in vitro thrombi formed in the presence of the labeled antibody, and in preformed ADP-induced platelet aggregates. Adenosine Diphosphate 197-200 fibrinogen beta chain Homo sapiens 34-44 4342212-9 1972 Studies of the redox state of NAD and cytochrome c show that addition of ADP during pyruvate oxidation causes a slight reduction, whereas addition during glycerol phosphate oxidation causes a ;classical" oxidation. Adenosine Diphosphate 73-76 cytochrome c, somatic Homo sapiens 38-50 5158897-14 1971 Studies on the effects of additions of adenine nucleotides to pyruvate metabolism by isolated fat-cell mitochondria are consistent with inhibition of pyruvate carboxylase in the presence of ADP and pyruvate dehydrogenase in the presence of ATP. Adenosine Diphosphate 190-193 pyruvate carboxylase Homo sapiens 150-170 4376842-0 1972 The effect of ADP and Mg++ ions on the interaction between mitochondrial cytochrome oxidase and exogenous cytochrome c. Adenosine Diphosphate 14-17 cytochrome c, somatic Homo sapiens 106-118 5289886-5 1971 In the presence of hexokinase and glucose, as well as arsenate and Mg(++), ADP inhibited H(+) uptake. Adenosine Diphosphate 75-78 hexokinase 1 Homo sapiens 19-29 4920873-0 1970 Glutamine synthetase deadenylation: a phosphorolytic reaction yielding ADP as nucleotide product. Adenosine Diphosphate 71-74 glutamate-ammonia ligase Homo sapiens 0-20 5503940-0 1970 Demonstration of a plasmatic cofactor different from fibrinogen necessary for platelet release by ADP and adrenaline. Adenosine Diphosphate 98-101 fibrinogen beta chain Homo sapiens 53-63 4312706-0 1970 The effect o angiotensin II on the platelet aggregation induced by adenosine diphosphate, epinephrine and thrombin. Adenosine Diphosphate 67-88 angiotensinogen Homo sapiens 13-27 5507209-1 1970 Formation of adenosine diphosphate from adenosine monophosphate and inorganic phosphate can be coupled to the oxidation of reduced glutathione by cytochrome c in a reaction which requires oxidized glutathione as a catalyst. Adenosine Diphosphate 13-34 cytochrome c, somatic Homo sapiens 146-158 5675431-17 1968 Sufficient ADP was released during exposure to thrombin and epinephrine to account for platelet agglutination. Adenosine Diphosphate 11-14 coagulation factor II, thrombin Homo sapiens 47-55 5822062-2 1969 The kinetics of inhibition of brain soluble cytoplasmic hexokinase by ADP were examined in relation to variations in the concentrations of Mg(2+) and ATP. Adenosine Diphosphate 70-73 hexokinase 1 Homo sapiens 56-66 5754842-4 1968 Another product prepared by digestion of fibrinogen with urokinase-activated plasminogen has been shown to possess the ability to enhance ADP-induced platelet aggregation. Adenosine Diphosphate 138-141 fibrinogen beta chain Homo sapiens 41-51 5649642-5 1968 Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4. Adenosine Diphosphate 125-128 coagulation factor II, thrombin Homo sapiens 144-152 5688928-12 1968 The reaction of ATP with adenosine kinase was competitively inhibited by AMP, GMP, IMP, ADP, deoxy-ADP and IDP (K(i) 0.2, 1.1, 5.9, 1.2, 0.5 and 0.78mm respectively). Adenosine Diphosphate 88-91 adenosine kinase Homo sapiens 25-41 5584022-2 1967 Treatment of the labelled and washed platelets with thrombin indicated that, though considerable amounts of ATP and ADP were released to the supernatant, radioactive ATP and ADP remained predominantly in the cellular fraction. Adenosine Diphosphate 116-119 coagulation factor II, thrombin Homo sapiens 52-60 5584022-2 1967 Treatment of the labelled and washed platelets with thrombin indicated that, though considerable amounts of ATP and ADP were released to the supernatant, radioactive ATP and ADP remained predominantly in the cellular fraction. Adenosine Diphosphate 174-177 coagulation factor II, thrombin Homo sapiens 52-60 5584022-5 1967 Evidence is given that the two pools contain approximately the same amounts of ATP plus ADP, and that the ratio of ATP to ADP in the pool released to the supernatant by the action of thrombin is about 0.7-0.8. Adenosine Diphosphate 122-125 coagulation factor II, thrombin Homo sapiens 183-191 4231625-0 1967 [Study of the effect of ADP and thrombin on fibrinogen, the stabilising factor of fibrin and thrombosthenine in human blood platelets]. Adenosine Diphosphate 24-27 fibrinogen beta chain Homo sapiens 44-54 14254709-0 1964 EFFECT OF FIBRINOGEN ON THE AGGREGATION OF PLATELETS BY ADENOSINE DIPHOSPHATE. Adenosine Diphosphate 56-77 fibrinogen beta chain Homo sapiens 10-20 5911299-0 1966 Binding of adenosine triphosphate and adenosine diphosphate by glutamine synthetase. Adenosine Diphosphate 38-59 glutamate-ammonia ligase Homo sapiens 63-83 5862557-0 1965 Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine diphosphate, thrombin, collagen, and adrenaline. Adenosine Diphosphate 86-107 fibrinogen beta chain Homo sapiens 13-23 33962616-10 2021 Functionally, blocking circ-CNST and restoring miR-578 enhanced apoptosis rate and suppressed cell proliferation, colony formation, migration, and invasion in 143B and U2OS cells, accompanied with decreased glucose consumption, lactate production, and adenosine triphosphate (ATP)/adenosine diphosphate (ADP) ratio. Adenosine Diphosphate 304-307 microRNA 578 Homo sapiens 47-54 13143054-0 1954 The inhibition of brain hexokinase by adenosinediphosphate and sulfhydryl reagents. Adenosine Diphosphate 38-58 hexokinase 1 Homo sapiens 24-34 33873056-6 2021 The distances from ADP to the His20 in the His-Ser-His motif and the Arg finger (Arg353 or Arg378) in both RUVBL1/2 complex structures bound with or without ADP have significant differences, suggesting dramatically different interactions of the binding site with ADP. Adenosine Diphosphate 19-22 RuvB like AAA ATPase 1 Homo sapiens 107-115 33873056-6 2021 The distances from ADP to the His20 in the His-Ser-His motif and the Arg finger (Arg353 or Arg378) in both RUVBL1/2 complex structures bound with or without ADP have significant differences, suggesting dramatically different interactions of the binding site with ADP. Adenosine Diphosphate 157-160 RuvB like AAA ATPase 1 Homo sapiens 107-115 33402044-8 2021 Consistent with previous studies, we found that ENPP1 preferred ATP as a substrate when compared with other nucleotides like GTP, ADP, and GDP. Adenosine Diphosphate 130-133 ectonucleotide pyrophosphatase/phosphodiesterase 1 Homo sapiens 48-53 33991007-7 2021 ATP, ADP and AMP as well as NAD+ , NADH, NADP+ and NADPH directly interact with CIRBP, involving both the folded RNA-recognition motif and the disordered RG/RGG region. Adenosine Diphosphate 5-8 cold inducible RNA binding protein Homo sapiens 80-85 33976187-3 2021 Here, we show that ADP-ribosylation regulates AR through a nuclear pathway mediated by Parp7. Adenosine Diphosphate 19-22 androgen receptor Homo sapiens 46-48 33976187-3 2021 Here, we show that ADP-ribosylation regulates AR through a nuclear pathway mediated by Parp7. Adenosine Diphosphate 19-22 TCDD inducible poly(ADP-ribose) polymerase Homo sapiens 87-92 14243776-0 1964 [ISOLATION OF AN ENZYME COMPLEX FROM THE ADP-ATP-REDUCED CYTOCHROME C EXCHANGE]. Adenosine Diphosphate 41-44 cytochrome c, somatic Homo sapiens 57-69 16810985-8 1962 From these results it is tentatively concluded that adhesion may involve intrinsic adenosine diphosphate in the platelet which may be activated by thrombin and inhibited by the added mono- or triphosphate. Adenosine Diphosphate 83-104 coagulation factor II, thrombin Homo sapiens 147-155 33873056-6 2021 The distances from ADP to the His20 in the His-Ser-His motif and the Arg finger (Arg353 or Arg378) in both RUVBL1/2 complex structures bound with or without ADP have significant differences, suggesting dramatically different interactions of the binding site with ADP. Adenosine Diphosphate 157-160 RuvB like AAA ATPase 1 Homo sapiens 107-115 33872376-5 2021 Concomitantly, LIG1 deficiency induces ADP-ribosylation of histone H3 in a PARP1-HPF1-dependent manner. Adenosine Diphosphate 39-42 histone H3 Xenopus laevis 59-69 33895438-8 2021 Arachidonic acid (AA), ADP and collagen induced an higher maximal aggregation, at turbidimetric evaluation, when PRP was pretreated with 100-500 ng/mL C6O4. Adenosine Diphosphate 23-26 complement component 4 binding protein alpha Homo sapiens 113-116 33070381-9 2021 The discordant effect of the differentially glycosylated AGP-1 glycoforms was also observed in platelets where neither of the AGP-1 glycoforms alone stimulated aggregation of washed human platelets, but sAGP-1, and not nAGP-1, inhibited aggregation induced by PAF or ADP, but not by thrombin. Adenosine Diphosphate 267-270 orosomucoid 1 Homo sapiens 57-62 33986729-7 2021 In the primary hepatocytes, ADP activated the cAMP/PKA/CREB signaling pathway, which was blocked by the antagonist (2211) of the ADP receptor P2Y13. Adenosine Diphosphate 28-31 cAMP responsive element binding protein 1 Mus musculus 55-59 33828561-12 2021 In parallel, ADP reduced reactive oxygen species (ROS) formation and tumor necrosis factor-alpha (TNF-alpha) levels, while increased IL-13 levels in the skin. Adenosine Diphosphate 13-16 tumor necrosis factor Mus musculus 69-96 33859040-9 2021 Collectively, our findings demonstrate that depolarization-dependent regulation of PLC-beta-IP3R signaling is required for modulation of the ATP/ADP ratio in healthy glutamatergic neurons, whereas hyperactivation of this axis in chronically depolarized glutamatergic neurons shortens animal lifespan by promoting endolysosomal Ca2+ overload. Adenosine Diphosphate 145-148 no receptor potential A Drosophila melanogaster 83-91 33997706-4 2021 Surprisingly, the expression of ARTD1 was accompanied by the continuous synthesis of nuclear ADP ribosylation that was neither dependent on the cell cycle nor induced by DNA damage. Adenosine Diphosphate 93-96 poly(ADP-ribose) polymerase 1 Homo sapiens 32-37 33997706-6 2021 Together, these data describe a MyoD-induced nucleoplasmic ADP-ribosylation that is observed particularly during transdifferentiation and thus potentially expands the plethora of cellular processes associated with ADP-ribosylation. Adenosine Diphosphate 59-62 myogenic differentiation 1 Homo sapiens 32-36 33997706-6 2021 Together, these data describe a MyoD-induced nucleoplasmic ADP-ribosylation that is observed particularly during transdifferentiation and thus potentially expands the plethora of cellular processes associated with ADP-ribosylation. Adenosine Diphosphate 214-217 myogenic differentiation 1 Homo sapiens 32-36 33828561-12 2021 In parallel, ADP reduced reactive oxygen species (ROS) formation and tumor necrosis factor-alpha (TNF-alpha) levels, while increased IL-13 levels in the skin. Adenosine Diphosphate 13-16 tumor necrosis factor Mus musculus 98-107 33828561-12 2021 In parallel, ADP reduced reactive oxygen species (ROS) formation and tumor necrosis factor-alpha (TNF-alpha) levels, while increased IL-13 levels in the skin. Adenosine Diphosphate 13-16 interleukin 13 Mus musculus 133-138 33645531-6 2021 However, the retention of ADP in the nucleotide-binding site of the structure strengthens the biochemical view that the release of ADP is a rate-limiting step in the ATPase cycle of CENP-E. Adenosine Diphosphate 26-29 centromere protein E Homo sapiens 182-188 33645531-6 2021 However, the retention of ADP in the nucleotide-binding site of the structure strengthens the biochemical view that the release of ADP is a rate-limiting step in the ATPase cycle of CENP-E. Adenosine Diphosphate 131-134 centromere protein E Homo sapiens 182-188 33497843-7 2021 ATP or ADP induced significantly greater production of IL-6 by HSC-2 cells. Adenosine Diphosphate 7-10 interleukin 6 Homo sapiens 55-59 33497843-9 2021 ATP or ADP induced the production of IL-6 by Ca9-22 cells, but the IL-6 concentration was much lower than that in HSC-2 cells. Adenosine Diphosphate 7-10 interleukin 6 Homo sapiens 37-41 33596198-7 2021 Strikingly, agonist-induced ADP release was 30- to 90-fold higher in COVID-19 patients compared with hospitalised controls and circulating levels of platelet factor 4 (PF4), soluble P-selectin (sP-selectin), and thrombopoietin (TPO) were also significantly elevated in COVID-19. Adenosine Diphosphate 28-31 thrombopoietin Homo sapiens 212-226 33717055-7 2020 These ADP-selective inhibitory effects of bedaquiline on platelet activation were mimicked by wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), implicating PI3-K as being a common target of both agents, a contention that was confirmed by the observed inhibitory effects of bedaquiline on the phosphorylation of Akt1 following activation of platelets with ADP. Adenosine Diphosphate 6-9 AKT serine/threonine kinase 1 Homo sapiens 328-332 33626394-5 2021 KEY FINDINGS: Compared with vehicle control, alcohol pretreatment significantly reduced hydrolysis of clopidogrel as a result of significant down-regulation of Nrf2-mediated Ces1 expression (responsible for the formation of clopidogrel carboxylate), increased metabolic activation of clopidogrel due to significant up-regulation of Cyp2c (for the formation of active thiol metabolite H4), and consequently enhanced inhibition of ADP-induced platelet aggregation and activation by clopidogrel. Adenosine Diphosphate 429-432 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 33626394-6 2021 SIGNIFICANCE: Short-term standard alcohol consumption would significantly enhance suppression of ADP-induced platelet aggregation and activation by clopidogrel through significant inhibition of Nrf2/Ces1 signaling pathway and induction of Cyp2c, suggesting that alcohol may interact with drugs that are predominantly metabolized by CES1 or CYP2C in patient care, including clopidogrel. Adenosine Diphosphate 97-100 NFE2 like bZIP transcription factor 2 Homo sapiens 194-198 33884168-10 2021 The docking studies also proposed the binding of PIP to ADP binding pocket of Apaf-1 protein. Adenosine Diphosphate 56-59 apoptotic peptidase activating factor 1 Homo sapiens 78-84 33596198-7 2021 Strikingly, agonist-induced ADP release was 30- to 90-fold higher in COVID-19 patients compared with hospitalised controls and circulating levels of platelet factor 4 (PF4), soluble P-selectin (sP-selectin), and thrombopoietin (TPO) were also significantly elevated in COVID-19. Adenosine Diphosphate 28-31 thrombopoietin Homo sapiens 228-231 33306443-8 2021 Receptor profiling studies demonstrated presence of P2Y1 and P2Y2 receptors, using ATP, UTP, ADP and the subtype specific agonists MRS2365 (P2Y1) and 2-thio-UTP (P2Y2)). Adenosine Diphosphate 93-96 purinergic receptor P2Y2 Bos taurus 61-65 33564083-4 2021 Platelets of ALOX12-deficient mice exhibit increased sensitivity for ADP-induced aggregation. Adenosine Diphosphate 69-72 arachidonate 12-lipoxygenase Mus musculus 13-19 33572475-1 2021 Poly-ADP-ribose polymerases (PARPs) are enzymes that catalyze ADP-ribosylation and play critical roles in normal and disease settings. Adenosine Diphosphate 5-8 poly(ADP-ribose) polymerase 1 Homo sapiens 29-34 33613545-10 2020 The TREM2-deficient cells presented with stronger increase in free cytosolic calcium upon stimulation with ATP and ADP, as well as stronger migration towards complement C5a, compared to TREM2 expressing cells. Adenosine Diphosphate 115-118 triggering receptor expressed on myeloid cells 2 Homo sapiens 4-9 33475084-1 2021 Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. Adenosine Diphosphate 5-8 TCDD inducible poly(ADP-ribose) polymerase Homo sapiens 31-37 33524397-5 2021 Using multi-angle light scattering (MALS) we show that ADP is able to promote tetramer formation of both CtBP1 and CtBP2, whereas AMP promotes tetramer assembly of CtBP1, but not CtBP2. Adenosine Diphosphate 55-58 C-terminal binding protein 2 Homo sapiens 115-120 33485373-5 2021 Unadjusted and adjusted logistic regression models taking into account age at evaluation, sex, and education examined the relationship between APOE epsilon4 genotype and initial symptoms (memory, executive, language visuospatial) among ADP with LRP and ADP-LRP groups. Adenosine Diphosphate 236-239 apolipoprotein E Homo sapiens 143-147 33485373-5 2021 Unadjusted and adjusted logistic regression models taking into account age at evaluation, sex, and education examined the relationship between APOE epsilon4 genotype and initial symptoms (memory, executive, language visuospatial) among ADP with LRP and ADP-LRP groups. Adenosine Diphosphate 236-239 LDL receptor related protein 1 Homo sapiens 245-248 33552071-6 2020 In this study we examine whether the SIRPalpha axis regulates ADP responses to the anti-CD20 antibody, obinutuzumab, by NLCs. Adenosine Diphosphate 62-65 signal regulatory protein alpha Homo sapiens 37-46 33552071-6 2020 In this study we examine whether the SIRPalpha axis regulates ADP responses to the anti-CD20 antibody, obinutuzumab, by NLCs. Adenosine Diphosphate 62-65 keratin 20 Homo sapiens 88-92 33552071-7 2020 Using siRNA depletion strategies we show that SIRPalpha is a suppressor of ADP responses. Adenosine Diphosphate 75-78 signal regulatory protein alpha Homo sapiens 46-55 33552071-9 2020 Finally, we show that SIRPalpha suppression is mediated via the phosphatase, Shp1, which in turn suppresses SYK-dependent activation of ADP. Adenosine Diphosphate 136-139 signal regulatory protein alpha Homo sapiens 22-31 33552071-11 2020 This is the first study to show that activation of the CD47:SIRPalpha innate immune checkpoint contributes to ADP resistance in NLCs from CLL patients. Adenosine Diphosphate 110-113 signal regulatory protein alpha Homo sapiens 60-69 33475084-7 2021 Proteome-wide ADP-ribosylation analysis reveals cysteine as a major MARylation acceptor of PARP-7. Adenosine Diphosphate 14-17 TCDD inducible poly(ADP-ribose) polymerase Homo sapiens 91-97 33403747-10 2021 Together with the ADP data our results propose a more efficient coupling of ATP hydrolysis and remodeling in CHD3. Adenosine Diphosphate 18-21 chromodomain helicase DNA binding protein 3 Homo sapiens 109-113 33450210-0 2021 Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation. Adenosine Diphosphate 50-53 poly(ADP-ribose) polymerase 1 Homo sapiens 36-41 33450210-6 2021 Elevated mitochondrial ADP-ribosylation, in turn, dampens H2O2-triggered nuclear ADP-ribosylation and increases MMS-induced ARTD1 chromatin retention. Adenosine Diphosphate 23-26 poly(ADP-ribose) polymerase 1 Homo sapiens 124-129 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 86-89 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-4 2022 In this study, using pull-down techniques, we have found that (1) GEC1 interacts with NSF directly and prefers the ADP-bound NSF to the ATP-bound NSF; (2) D1 and/or D2 domain(s) of NSF interact with GEC1, but the N domain of NSF does not; (3) NSF does not interact with KCT directly, but forms a protein complex with KCT via GEC1; (4) NSF and/or alpha-SNAP do not affect KCT-GEC1 interaction. Adenosine Diphosphate 115-118 vesicle-fusing ATPase Cricetulus griseus 125-128 33404775-5 2022 Thus, GEC1 (vs the alpha-SNAP/SNAREs complex) binds to NSF in distinctive ways in terms of the ADP- or ATP-bound form and domains of NSF involved. Adenosine Diphosphate 95-98 vesicle-fusing ATPase Cricetulus griseus 55-58 33143630-6 2021 A permanent increase of ATP/ADP ratio leads to a constant inhibition of K+ ATP-channel and therefore a continuous insulin secretion accompanied by an increase in ROS. Adenosine Diphosphate 28-31 insulin Homo sapiens 114-121 33641653-8 2021 Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. Adenosine Diphosphate 31-34 hypoxia inducible factor 1 subunit alpha Homo sapiens 54-59 33641653-8 2021 Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. Adenosine Diphosphate 31-34 tumor protein p53 Homo sapiens 103-106 33641653-8 2021 Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. Adenosine Diphosphate 31-34 hypoxia inducible factor 1 subunit alpha Homo sapiens 176-181 33641653-11 2021 ADP promotes erythropoiesis in myelodysplastic syndromes via downregulation of HIF1A and upregulation of GATA factors. Adenosine Diphosphate 0-3 hypoxia inducible factor 1 subunit alpha Homo sapiens 79-84 33374308-5 2020 Actin-triggered Pi release was accelerated, while ADP release considerably decelerated, both limiting maximum ATPase, thus transforming myosin-2 into a high-duty-ratio motor. Adenosine Diphosphate 50-53 myosin heavy chain 2 Homo sapiens 136-144 32557253-10 2021 CONCLUSIONS: Our results suggest a protection role of the rs4884 polymorphism against knee OA development; further studies are required to confirm it.Key Points CK-MM enzyme catalyzes the conversion of creatine and ATP to create phosphocreatine and ADP; this reaction is reversible. Adenosine Diphosphate 250-253 creatine kinase, M-type Homo sapiens 162-167 31949019-6 2021 The differential effect of Btk inhibition in CLEC-2 relative to GPVI signalling is explained by the positive feedback role involving Btk itself, as well as ADP and thromboxane A2 mediated activation of P2Y12 and TP receptors, respectively. Adenosine Diphosphate 156-159 C-type lectin domain family 1 member B Homo sapiens 45-51 33107611-7 2021 Adenosine diphosphate (ADP)-induced Akt phosphorylation was determined by western blot. Adenosine Diphosphate 23-26 AKT serine/threonine kinase 1 Homo sapiens 36-39 33107611-12 2021 ADP-induced Akt phosphorylation was enhanced in irradiated PAS-PCs. Adenosine Diphosphate 0-3 AKT serine/threonine kinase 1 Homo sapiens 12-15 33307675-1 2020 ADP-mediated platelet aggregation is signaled through G protein-coupled receptors P2Y1 and P2Y12 on the platelet. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Rattus norvegicus 82-86 33376942-8 2020 In patients with confirmed PFD, median closure times were 107 seconds (ADP or adenosine diphosphate; IQR 89, 130) and 169 seconds (EPI; IQR 121, 211). Adenosine Diphosphate 71-74 complement factor properdin Homo sapiens 27-30 32898647-3 2020 The features of energy sensing and ADP-ribose transference of SIRT3 have also been reported. Adenosine Diphosphate 35-38 sirtuin 3 Homo sapiens 62-67 33337519-6 2021 On-treatment residual AA- and ADP-inducible platelet reactivity was significantly higher in patients with ACE inhibitors (both p < 0.05). Adenosine Diphosphate 30-33 angiotensin I converting enzyme Homo sapiens 106-109 33295873-4 2020 Here we report that calcium selectively affects the dynamics of the abundant metazoan ER Hsp70 chaperone BiP, by enhancing its affinity for ADP. Adenosine Diphosphate 140-143 heat shock protein family A (Hsp70) member 5 Homo sapiens 105-108 33295873-5 2020 In the calcium-replete ER, ADP rebinding to post-ATP hydrolysis BiP-substrate complexes competes with ATP binding during both spontaneous and co-chaperone-assisted nucleotide exchange, favouring substrate retention. Adenosine Diphosphate 27-30 heat shock protein family A (Hsp70) member 5 Homo sapiens 64-67 33199206-9 2020 CONCLUSIONS: Elevation in circulating hepatic ALAS1 and response to treatment with hemin indicate that the liver is an important source of excess ALA in ADP, although the marrow may also contribute. Adenosine Diphosphate 153-156 5'-aminolevulinate synthase 1 Homo sapiens 46-51 32356316-4 2020 MA increased generation of nitric oxide, but downregulated excessive secretion of endothelin-1 in ADP- or U46619-treated human umbilical vein endothelial cells. Adenosine Diphosphate 98-101 endothelin 1 Homo sapiens 82-94 33158052-6 2020 In addition, CP-induced PARP-1 activation led to ADP-ribosylation of HMGB1, which consequently developed autophagy as evident by the LC3I/II ratio. Adenosine Diphosphate 49-52 poly(ADP-ribose) polymerase 1 Homo sapiens 24-30 32941855-5 2020 These effects of ATP or ADP were blocked by inhibitors of P2X7 or P2Y12 receptor, respectively, and by ERK1/2 inhibitor. Adenosine Diphosphate 24-27 mitogen-activated protein kinase 3 Homo sapiens 103-109 32941855-6 2020 ATP and ADP enhanced phosphorylation of ERK1/2 by suppressing MKP-1 and MKP-3 expression after gamma-irradiation. Adenosine Diphosphate 8-11 mitogen-activated protein kinase 3 Homo sapiens 40-46 32941855-6 2020 ATP and ADP enhanced phosphorylation of ERK1/2 by suppressing MKP-1 and MKP-3 expression after gamma-irradiation. Adenosine Diphosphate 8-11 dual specificity phosphatase 1 Homo sapiens 62-67 32941855-7 2020 These results indicate that ATP and ADP exhibit radioprotective effects by phosphorylation of ERK1/2 via activation of P2X7 and P2Y12 receptors, respectively, to promote gamma-irradiation-induced DDR and DNA repair. Adenosine Diphosphate 36-39 mitogen-activated protein kinase 3 Homo sapiens 94-100 33186521-0 2020 An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation. Adenosine Diphosphate 60-63 histone PARylation factor 1 Homo sapiens 3-7 33186521-0 2020 An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation. Adenosine Diphosphate 60-63 poly(ADP-ribose) polymerase 1 Homo sapiens 8-13 32845180-4 2020 We describe the methodology for this integration and present a proof-of-concept application to the treatment of non-small cell lung cancer (NSCLC) with EGFR mutation with osimertinib.Materials and methods: For better accuracy in estimating the ADP, we used the prices generated from the six dimensions at scenario levels, not at the dimension-specific price (DSP) level. Adenosine Diphosphate 244-247 epidermal growth factor receptor Homo sapiens 152-156 33147484-6 2020 Our findings support a compartmentalized model of beta cell metabolism in which PK locally generates the ATP/ADP required for insulin secretion. Adenosine Diphosphate 109-112 insulin Homo sapiens 126-133 32518369-4 2020 Consequently, extracellular ADP activated the NLRP3 inflammasome through P2Y1 receptor-mediated calcium signaling, which led to the maturation and secretion of IL-1beta and further aggravation of experimental colitis. Adenosine Diphosphate 28-31 NLR family pyrin domain containing 3 Homo sapiens 46-51 32817166-7 2020 In the presence of actin, ADP affinity (KAD) is unchanged for IFI-3a, compared to IFI, but ADP-affinity for EMB-3b is increased, compared to EMB, and shifted towards IFI values. Adenosine Diphosphate 26-29 Actin 79B Drosophila melanogaster 19-24 32817166-7 2020 In the presence of actin, ADP affinity (KAD) is unchanged for IFI-3a, compared to IFI, but ADP-affinity for EMB-3b is increased, compared to EMB, and shifted towards IFI values. Adenosine Diphosphate 91-94 Actin 79B Drosophila melanogaster 19-24 33036374-6 2020 Novel molecular dynamic simulations of NLRP3 examined the active site of ADP- and ATP-bound models. Adenosine Diphosphate 73-76 NLR family pyrin domain containing 3 Homo sapiens 39-44 32827244-1 2020 Acylglycerol kinase (AGK) uses adenosine triphosphate (ATP) and acylglycerol to generate adenosine diphosphate (ADP) and acyl-sn-glycerol 3-phosphate in cells. Adenosine Diphosphate 112-115 acylglycerol kinase Homo sapiens 21-24 32717630-12 2020 The hemostatic mechanism may involve activation of the P2Y1, P2Y12, and PKC receptors in the adenosine diphosphate (ADP) receptor signaling pathway. Adenosine Diphosphate 116-119 purinergic receptor P2Y1 Rattus norvegicus 55-59 33041851-7 2020 ADP and cyclosporine A (CsA), which are known to increase Ca2+ buffering while maintaining a constant [mCa2+]ss, decreased the rate of Ca2+ efflux via the CHE, with a significantly greater decrease in the presence of ADP. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Mus musculus 58-61 33002037-8 2020 These findings reveal that microtubule disorganization in dystrophin-deficient EDL is associated with impaired ADP control of mitochondrial bioenergetics, and suggests that mechanisms alternative to alpha-tubulin"s regulation of VDAC2 should be examined to understand how cytoskeletal disruption in the absence of dystrophin may cause metabolic dysfunctions in skeletal muscle. Adenosine Diphosphate 111-114 dystrophin, muscular dystrophy Mus musculus 58-68 33041851-8 2020 ADP also increased Ca2+ buffering rate and decreased [mCa2+]ss. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Mus musculus 19-22 33041851-8 2020 ADP also increased Ca2+ buffering rate and decreased [mCa2+]ss. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Mus musculus 54-58 33041851-7 2020 ADP and cyclosporine A (CsA), which are known to increase Ca2+ buffering while maintaining a constant [mCa2+]ss, decreased the rate of Ca2+ efflux via the CHE, with a significantly greater decrease in the presence of ADP. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Mus musculus 103-107 33041851-7 2020 ADP and cyclosporine A (CsA), which are known to increase Ca2+ buffering while maintaining a constant [mCa2+]ss, decreased the rate of Ca2+ efflux via the CHE, with a significantly greater decrease in the presence of ADP. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Mus musculus 104-107 32947765-8 2020 The closed conformation maintained the crucial salt-bridge between Glu-268 and Lys-56 residues, which strengthens the interaction affinity of the inhibitor nearly identical to adenosine triphosphate (ADP/Pi) bound to the HSP72-NBD. Adenosine Diphosphate 200-203 heat shock protein family A (Hsp70) member 1A Homo sapiens 221-226 32744742-5 2020 Such dramatic effects were likely due to an essential role of COX6A2 in energy balance of PV+ interneurons, underscored by a decrease in the ATP-to-ADP ratio in Cox6a2-/- PV+ interneurons. Adenosine Diphosphate 148-151 cytochrome c oxidase subunit 6A2 Mus musculus 62-68 32744742-5 2020 Such dramatic effects were likely due to an essential role of COX6A2 in energy balance of PV+ interneurons, underscored by a decrease in the ATP-to-ADP ratio in Cox6a2-/- PV+ interneurons. Adenosine Diphosphate 148-151 cytochrome c oxidase subunit 6A2 Mus musculus 161-167 32588751-6 2020 Methods and Results: Using platelets from wild-type or SERCA3-deficient mice, we demonstrated that an early (within 5 to 10 seconds following stimulation) secretion of ADP specifically dependent on SERCA3 stored Ca2+ is exclusively mobilized by nicotinic acid adenosine dinucleotide phosphate (NAADP): both Ca2+ mobilization from SERCA3-dependent stores and primary ADP secretion are blocked by the NAADP receptor antagonist Ned-19, and reciprocally both are stimulated by permeant NAADP. Adenosine Diphosphate 296-299 ATPase, Ca++ transporting, ubiquitous Mus musculus 198-204 32588751-6 2020 Methods and Results: Using platelets from wild-type or SERCA3-deficient mice, we demonstrated that an early (within 5 to 10 seconds following stimulation) secretion of ADP specifically dependent on SERCA3 stored Ca2+ is exclusively mobilized by nicotinic acid adenosine dinucleotide phosphate (NAADP): both Ca2+ mobilization from SERCA3-dependent stores and primary ADP secretion are blocked by the NAADP receptor antagonist Ned-19, and reciprocally both are stimulated by permeant NAADP. Adenosine Diphosphate 296-299 ATPase, Ca++ transporting, ubiquitous Mus musculus 198-204 32588751-0 2020 NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation. Adenosine Diphosphate 2-5 ATPase, Ca++ transporting, ubiquitous Mus musculus 6-12 32588751-8 2020 Conclusions: Upon activation a NAADP/SERCA3 Ca2+ mobilization pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave of ADP secretion driven by both an IP3/SERCA2b-dependent Ca2+ stores pathway and the NAADP/SERCA3 pathway. Adenosine Diphosphate 33-36 ATPase, Ca++ transporting, ubiquitous Mus musculus 37-43 32588751-5 2020 Objective: To uncover the signaling mechanisms associated with Ca2+ mobilization from SERCA3-dependent stores leading to ADP secretion. Adenosine Diphosphate 121-124 ATPase, Ca++ transporting, ubiquitous Mus musculus 86-92 32588751-6 2020 Methods and Results: Using platelets from wild-type or SERCA3-deficient mice, we demonstrated that an early (within 5 to 10 seconds following stimulation) secretion of ADP specifically dependent on SERCA3 stored Ca2+ is exclusively mobilized by nicotinic acid adenosine dinucleotide phosphate (NAADP): both Ca2+ mobilization from SERCA3-dependent stores and primary ADP secretion are blocked by the NAADP receptor antagonist Ned-19, and reciprocally both are stimulated by permeant NAADP. Adenosine Diphosphate 168-171 ATPase, Ca++ transporting, ubiquitous Mus musculus 55-61 32588751-6 2020 Methods and Results: Using platelets from wild-type or SERCA3-deficient mice, we demonstrated that an early (within 5 to 10 seconds following stimulation) secretion of ADP specifically dependent on SERCA3 stored Ca2+ is exclusively mobilized by nicotinic acid adenosine dinucleotide phosphate (NAADP): both Ca2+ mobilization from SERCA3-dependent stores and primary ADP secretion are blocked by the NAADP receptor antagonist Ned-19, and reciprocally both are stimulated by permeant NAADP. Adenosine Diphosphate 168-171 ATPase, Ca++ transporting, ubiquitous Mus musculus 198-204 32588751-8 2020 Conclusions: Upon activation a NAADP/SERCA3 Ca2+ mobilization pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave of ADP secretion driven by both an IP3/SERCA2b-dependent Ca2+ stores pathway and the NAADP/SERCA3 pathway. Adenosine Diphosphate 89-92 ATPase, Ca++ transporting, ubiquitous Mus musculus 37-43 32588751-6 2020 Methods and Results: Using platelets from wild-type or SERCA3-deficient mice, we demonstrated that an early (within 5 to 10 seconds following stimulation) secretion of ADP specifically dependent on SERCA3 stored Ca2+ is exclusively mobilized by nicotinic acid adenosine dinucleotide phosphate (NAADP): both Ca2+ mobilization from SERCA3-dependent stores and primary ADP secretion are blocked by the NAADP receptor antagonist Ned-19, and reciprocally both are stimulated by permeant NAADP. Adenosine Diphosphate 168-171 ATPase, Ca++ transporting, ubiquitous Mus musculus 198-204 32825435-1 2020 Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. Adenosine Diphosphate 231-234 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 0-51 32529831-5 2020 Finally, PARP inhibition was used to perturb the characterized systems, demonstrating the importance of ADP-ribosylation for the global interactome. Adenosine Diphosphate 104-107 poly(ADP-ribose) polymerase 1 Homo sapiens 9-13 32922055-13 2020 Lept/ADP ratio, an inflammatory marker, was associated with risk of insulin resistance. Adenosine Diphosphate 5-8 insulin Homo sapiens 68-75 32825435-1 2020 Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme that is expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulating local concentrations of extracellular ATP and ADP. Adenosine Diphosphate 231-234 ectonucleoside triphosphate diphosphohydrolase 2 Mus musculus 53-61 32514607-7 2020 Maximal ADP-stimulated mitochondrial respiration normalized by citrate synthase increased (P < 0.05) by 67% and 36% in MICT and HIIT, respectively, without significant difference. Adenosine Diphosphate 8-11 citrate synthase Homo sapiens 63-79 32676607-9 2020 We also observe ADP-Mg2+ bound in the nsp12 N-terminal nidovirus RdRp-associated nucleotidyltransferase domain, detailing a new pocket for anti-viral therapeutic development. Adenosine Diphosphate 16-19 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 65-69 31684789-6 2020 Furthermore, P2Y12 receptor (P2Y12R) activity as assessed by ADP-mediated reduction of VASP phosphorylation is enhanced in arr3-/-mice. Adenosine Diphosphate 61-64 vasodilator-stimulated phosphoprotein Mus musculus 87-91 32803122-11 2020 Conclusion ADP responsiveness is preserved under cold storage for 6 days due to stable P2Y12 activity and concomitant disintegration of inhibitory pathways enabling a higher reactivity of stored platelets. Adenosine Diphosphate 12-15 purinergic receptor P2Y12 Homo sapiens 88-93 32434052-9 2020 Additionally, empagliflozin-mediated AMPK activation prevented LPS-induced ATP/ADP depletion. Adenosine Diphosphate 79-82 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 37-41 32501673-3 2020 We have shown that cleavage of the multifunctional azobenzene group in AP-N N-Cy only occurred in the presence of azoreductase, which specifically secretes in the colon, resulting in direct release of AdP through an in situ modification of a phenylamino group on the precursor AP. Adenosine Diphosphate 201-204 alanyl aminopeptidase, membrane Homo sapiens 71-75 32431608-11 2020 5HD reduced the ADP-stimulated respiration in the HSP10 group (65.84 +- 3.3 nmol O2/min/mg PTN), ATP production (193.7 +- 12.1 mumol ATP/200mug PTN) and increased ROS in the 5-10-sP group (274.4 +- 21.7 nmol H2O2/200 mug PTN). Adenosine Diphosphate 16-19 pleiotrophin Rattus norvegicus 91-94 31649128-0 2020 Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies. Adenosine Diphosphate 27-30 purinergic receptor P2Y12 Homo sapiens 111-116 32365642-7 2020 The function of microglia is regulated by a whole array of purinergic receptors classified as P2Y12, P2Y6, P2Y4, P2X4, P2X7, A2A, and A3, as targets of endogenous ATP, ADP, or adenosine. Adenosine Diphosphate 168-171 purinergic receptor P2Y12 Homo sapiens 94-99 32365642-7 2020 The function of microglia is regulated by a whole array of purinergic receptors classified as P2Y12, P2Y6, P2Y4, P2X4, P2X7, A2A, and A3, as targets of endogenous ATP, ADP, or adenosine. Adenosine Diphosphate 168-171 purinergic receptor P2X 4 Homo sapiens 113-117 31928132-6 2020 We further demonstrated that SIRT6 and PARP1 activation were required for chemotherapy-induced ADP-ribosylation of HMGB1 in leukemic cells and then influenced the acetylation of HMGB1, finally promoting the autophagy of leukemic cells mediated by HMGB1 translocation. Adenosine Diphosphate 95-98 sirtuin 6 Homo sapiens 29-34 31928132-6 2020 We further demonstrated that SIRT6 and PARP1 activation were required for chemotherapy-induced ADP-ribosylation of HMGB1 in leukemic cells and then influenced the acetylation of HMGB1, finally promoting the autophagy of leukemic cells mediated by HMGB1 translocation. Adenosine Diphosphate 95-98 high mobility group box 1 Homo sapiens 115-120 32185076-9 2020 Usually, AMPK can be activated by ADP or AMP, upstream kinases or other cytokines, and pharmacological agents, and then it phosphorylates key molecules that are involved in energy metabolism, autophagy, anti-inflammation, oxidative stress, and aging process to keep cellular homeostasis and finally keeps cell normal activity and function. Adenosine Diphosphate 34-37 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 9-13 32049026-2 2020 Among the multitude of gephyrin-binding proteins is IQSEC3, a recently identified component at GABAergic synapses that acts through its ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF) activity to orchestrate GABAergic synapse formation. Adenosine Diphosphate 136-139 gephyrin Mus musculus 23-31 32082171-3 2019 Hydrolysis of nucleotides ATP and ADP is regulated by two ectonucleotidases, triphosphate diphosphohydrolase-1 (NTPDase-1/CD39) and ecto-5"-nucleotidase (ecto-5"-NT/CD73). Adenosine Diphosphate 34-37 5' nucleotidase, ecto Rattus norvegicus 132-152 32082171-3 2019 Hydrolysis of nucleotides ATP and ADP is regulated by two ectonucleotidases, triphosphate diphosphohydrolase-1 (NTPDase-1/CD39) and ecto-5"-nucleotidase (ecto-5"-NT/CD73). Adenosine Diphosphate 34-37 5' nucleotidase, ecto Rattus norvegicus 165-169 31648640-6 2020 The GSK-3beta activity was measured through the ADP-Glo Kinase Assay, which quantifies the kinasedependent enzymatic production of ADP from ATP, using a coupled-luminescence-based reaction. Adenosine Diphosphate 48-51 glycogen synthase kinase 3 alpha Homo sapiens 4-13 33146056-3 2020 CD39 processes pro-inflammatory extracellular ATP to ADP and AMP, which is then processed by Ecto-5"-nucleotidase/CD73 to immunosuppressive adenosine. Adenosine Diphosphate 53-56 5'-nucleotidase ecto Homo sapiens 93-113 33146056-3 2020 CD39 processes pro-inflammatory extracellular ATP to ADP and AMP, which is then processed by Ecto-5"-nucleotidase/CD73 to immunosuppressive adenosine. Adenosine Diphosphate 53-56 5'-nucleotidase ecto Homo sapiens 114-118 31897149-0 2020 Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells. Adenosine Diphosphate 6-9 high mobility group box 1 Homo sapiens 27-32 31897149-0 2020 Poly (ADP-ribosylation) of HMGB1 facilitates its acetylation and promotes HMGB1 translocation-associated chemotherapy-induced autophagy in leukaemia cells. Adenosine Diphosphate 6-9 high mobility group box 1 Homo sapiens 74-79 31897149-6 2020 It was further demonstrated that poly (ADP-ribosylation) of HMGB1 facilitates its acetylation, thereby inducing HMGB1 translocation and ultimately promoting chemotherapy-induced autophagy in leukaemic cells. Adenosine Diphosphate 39-42 high mobility group box 1 Homo sapiens 60-65 31897149-6 2020 It was further demonstrated that poly (ADP-ribosylation) of HMGB1 facilitates its acetylation, thereby inducing HMGB1 translocation and ultimately promoting chemotherapy-induced autophagy in leukaemic cells. Adenosine Diphosphate 39-42 high mobility group box 1 Homo sapiens 112-117 30744477-5 2020 Studies investigating the residual platelet reactivity categorized by smoking status and patients treated with platelet ADP-P2Y12 receptor inhibitors qualified the inclusion criteria. Adenosine Diphosphate 120-123 purinergic receptor P2Y12 Homo sapiens 124-129 30810440-3 2020 Thrombin activates platelets via the protease-activated receptors (PARs) 1 and 4, whereas ADP signals via the receptors P2Y1 and P2Y12 as a positive feedback mediator of platelet activation. Adenosine Diphosphate 90-93 purinergic receptor P2Y12 Homo sapiens 129-134 31776250-11 2019 The latter result suggests that the ATP binding in one beta subunit and the adenosine 5"-diphosphate (ADP) release from another beta subunit occur via a transient whose lifetime is ~10 mus and is about 6 orders of magnitude smaller than the lifetime for ADP release from a singly occupied [Formula: see text]-ATPase. Adenosine Diphosphate 76-100 dynein axonemal heavy chain 8 Homo sapiens 309-315 31776250-11 2019 The latter result suggests that the ATP binding in one beta subunit and the adenosine 5"-diphosphate (ADP) release from another beta subunit occur via a transient whose lifetime is ~10 mus and is about 6 orders of magnitude smaller than the lifetime for ADP release from a singly occupied [Formula: see text]-ATPase. Adenosine Diphosphate 102-105 dynein axonemal heavy chain 8 Homo sapiens 309-315 31776250-11 2019 The latter result suggests that the ATP binding in one beta subunit and the adenosine 5"-diphosphate (ADP) release from another beta subunit occur via a transient whose lifetime is ~10 mus and is about 6 orders of magnitude smaller than the lifetime for ADP release from a singly occupied [Formula: see text]-ATPase. Adenosine Diphosphate 254-257 dynein axonemal heavy chain 8 Homo sapiens 309-315 31278906-2 2019 SARM1 activity depends on the integrity of the protein"s SAM domains, as well as on the enzymatic conversion of NAD+ to ADPR (ADP Ribose) products by the SARM1"s TIR domain. Adenosine Diphosphate 120-123 sterile alpha and TIR motif containing 1 Homo sapiens 0-5 31278906-2 2019 SARM1 activity depends on the integrity of the protein"s SAM domains, as well as on the enzymatic conversion of NAD+ to ADPR (ADP Ribose) products by the SARM1"s TIR domain. Adenosine Diphosphate 120-123 sterile alpha and TIR motif containing 1 Homo sapiens 154-159 30861254-7 2019 RESULTS: Five SUR1 missense mutations, D212Y, P254S, R653Q, R992C, and Q1224H, were studied and showed increased activity in MgATP/MgADP. Adenosine Diphosphate 131-136 ATP binding cassette subfamily C member 8 Homo sapiens 14-18 30919205-6 2019 We found that the addition of exogenous ADP or overexpression of P2Y1 receptors significantly increased IL-2 mRNA transcription in response to TCR/CD28 stimulation. Adenosine Diphosphate 40-43 CD28 molecule Homo sapiens 147-151 31218061-7 2019 Collectively, this study quantitatively analysed the conformational changes of AtHsp90.6 bound to ATP or ADP. Adenosine Diphosphate 105-108 HEAT SHOCK PROTEIN 89.1 Arabidopsis thaliana 79-88 30836318-1 2019 AMP-activated protein kinase (AMPK) plays a major role in maintaining cellular energy homeostasis by sensing and responding to AMP/ADP concentrations relative to ATP. Adenosine Diphosphate 131-134 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 30836318-1 2019 AMP-activated protein kinase (AMPK) plays a major role in maintaining cellular energy homeostasis by sensing and responding to AMP/ADP concentrations relative to ATP. Adenosine Diphosphate 131-134 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 30700550-7 2019 Direct complex I inhibition with rotenone mimicked the restrictive effects of CDK1 inhibition on mitochondrial respiration, NADH turnover, ATP/ADP, and calcium influx. Adenosine Diphosphate 143-146 cyclin-dependent kinase 1 Mus musculus 78-82 29671861-2 2019 Adenosine diphosphate (ADP) receptors P2Y1 and P2Y12 both play a role in platelet activation, The present hypothesis herein is that the inhibition of these receptors may affect the release of PEVs. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 47-52 29671861-7 2019 RESULTS: ADP-induced aggregation (57 +- 13 area under curve {AUC] units) was inhibited 73% by the P2Y1 antagonist, 86% by the P2Y12 antagonist, and 95% when combined (p < 0.001 for all). Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 126-131 30734681-3 2019 Recently, the important role in the platelet aggregation of adenosine diphosphate (ADP)-activated P2Y12 and P2Y1 receptors, Gprotein coupled receptors of the P2 purinergic family, has emerged, and their inhibitors are explored as potential therapeutic antithrombotics. Adenosine Diphosphate 83-86 purinergic receptor P2Y12 Homo sapiens 98-103 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 6-54 32181500-1 2020 AMPK (adenosine monophosphate-activated protein kinase) is phosphorylated (AMPK-P) in response to low energy through allosteric activation by Adenosine mono- or diphosphate (AMP/ADP). Adenosine Diphosphate 178-181 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 75-79 32464678-2 2020 ADP, either derived from red blood cells or released by platelets themselves, stimulates platelets via two G protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 145-150 32102842-5 2020 Here, we report the crystal structures of cyanobacterial (Synechococcus elongatus) PRK in complex with adenosine diphosphate and glucose-6-phosphate, and of the Arabidopsis thaliana GAPDH/CP12/PRK complex, providing detailed information regarding the active site of PRK, and the key elements essential for PRK-CP12 interaction. Adenosine Diphosphate 103-124 phosphoribulokinase Arabidopsis thaliana 83-86 32198203-5 2020 The conformational distribution in the ATP-bound state can be induced by Hdj1 to form an "ADP-like" undocked conformation, which is an ATPase-stimulated state. Adenosine Diphosphate 90-93 DnaJ heat shock protein family (Hsp40) member B1 Homo sapiens 73-77 31928132-0 2020 SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia. Adenosine Diphosphate 33-40 sirtuin 6 Homo sapiens 0-5 31928132-0 2020 SIRT6-PARP1 is involved in HMGB1 polyADP-ribosylation and acetylation and promotes chemotherapy-induced autophagy in leukemia. Adenosine Diphosphate 33-40 high mobility group box 1 Homo sapiens 27-32 31928132-5 2020 Meanwhile, we found that SIRT6, an important upstream protein of PARP1, associated with PARP1, leading to the stimulation of polyADP-ribose polymerase activity. Adenosine Diphosphate 125-132 sirtuin 6 Homo sapiens 25-30 32067141-3 2020 Similarly, signalling through P2Y12 and P2Y13 receptors coupled to Gi/o proteins is initiated by the ATP breakdown product ADP. Adenosine Diphosphate 123-126 purinergic receptor P2Y13 Rattus norvegicus 40-45 32067141-4 2020 Hence, this study has pharmacologically investigated a possible role of ADP-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats, using a stable ADP analogue (ADPbetaS) and selective antagonists for the purinergic P2Y1, P2Y12 and P2Y13 receptors. Adenosine Diphosphate 72-75 purinergic receptor P2Y13 Rattus norvegicus 254-259 31800116-8 2020 Driven by ATP binding and hydrolysis and GroES binding, GroEL undergoes a catalytic cycle during which it samples three allosteric states, T (apo), R (ATP bound), and R"" (ADP bound). Adenosine Diphosphate 172-175 heat shock protein family E (Hsp10) member 1 Homo sapiens 41-46 31973218-11 2020 There are methodological differences between ADP and DXA measures for infants with higher fat mass. Adenosine Diphosphate 45-48 FAT atypical cadherin 1 Homo sapiens 90-93 31968611-1 2020 Background: Extensive research has reported that extracellular ADP in the tumour microenvironment can stimulate platelets through interaction with the platelet receptor P2Y12. Adenosine Diphosphate 63-66 purinergic receptor P2Y12 Homo sapiens 169-174 31899801-6 2020 Responses to PAR4 agonist or adenosine 5"-diphosphate stimulation in GRK6-/- platelets are increased compared with WT littermates, whereas the response to thromboxane A2 (TxA2) is normal. Adenosine Diphosphate 29-53 G protein-coupled receptor kinase 6 Homo sapiens 69-73 32009900-1 2019 ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Adenosine Diphosphate 0-3 ADP-ribosyltransferase 2a Mus musculus 93-98 32009900-1 2019 ADP-ribosylation of the P2X7k splice variant on mouse T cells by Ecto-ADP-ribosyltransferase ARTC2.2 in response to its substrate extracellular nicotinamide adenine dinucleotide (NAD+) triggers cell death. Adenosine Diphosphate 70-73 ADP-ribosyltransferase 2a Mus musculus 93-98 32009900-5 2019 We found that astrocytes and microglia strongly upregulate cell surface levels of ARTC2.1 and ADP-ribosylation of cell surface proteins in response to treatment with lipopolysaccharide (LPS) and the mitogen-activated protein kinase kinase (MEK) 1 and 2 inhibitor U0126, but do not respond to extracellular NAD+ with P2X7 activation and induction of cell death. Adenosine Diphosphate 94-97 mitogen-activated protein kinase kinase 1 Mus musculus 199-252 32034708-2 2020 P2Y1 and P2Y12 both respond to ADP, but while P2Y1 links to PLC and elevates cytosolic Ca2+ concentration, P2Y12 negatively couples to adenylate cyclase, maintaining cAMP at low level. Adenosine Diphosphate 31-34 purinergic receptor P2Y12 Homo sapiens 9-14 32034708-4 2020 During prolonged serum deprivation, cell growth is arrested, the expression of the P2Y1 receptor strongly decreases and P2Y12 becomes a major player responsible for ADP-evoked signal transduction. Adenosine Diphosphate 165-168 purinergic receptor P2Y12 Homo sapiens 120-125 32085886-8 2020 ADP to ATP conversion plays a crucial role in switching the closed-form of NOD2 protein to the open-form, thus activating the protein. Adenosine Diphosphate 0-3 nucleotide binding oligomerization domain containing 2 Homo sapiens 75-79 32085886-13 2020 Molecular docking analysis was carried out to understand the change in the interaction of ADP with the NOD2 protein. Adenosine Diphosphate 90-93 nucleotide binding oligomerization domain containing 2 Homo sapiens 103-107 32085886-14 2020 We observed that ADP had a stronger interaction with the native NOD2 protein compared to the W490L mutant. Adenosine Diphosphate 17-20 nucleotide binding oligomerization domain containing 2 Homo sapiens 64-68 32085886-15 2020 Finally, ADP complexed with native NOD2 and W490L mutant were subjected to molecular dynamics simulations, and the trajectories were analyzed. Adenosine Diphosphate 9-12 nucleotide binding oligomerization domain containing 2 Homo sapiens 35-39 31848352-3 2019 We characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks, which reveal that PARP1 associates faster with (gamma)H2A.X- versus H2A-nucleosomes, resulting in a higher affinity for the former, which is maximal for gammaH2A.X-nucleosome that is also the activator eliciting the greatest poly-ADP-ribosylation catalytic efficiency. Adenosine Diphosphate 336-344 H2A.X variant histone Homo sapiens 159-170 31604522-5 2019 Both the ADP binding pocket and the putative AtSrx-AtPrxA interaction surface of AtSrx are more positively charged comparing to HsSrx, suggesting a robust mechanism of AtSrx. Adenosine Diphosphate 9-12 sulfiredoxin Arabidopsis thaliana 81-86 31604522-5 2019 Both the ADP binding pocket and the putative AtSrx-AtPrxA interaction surface of AtSrx are more positively charged comparing to HsSrx, suggesting a robust mechanism of AtSrx. Adenosine Diphosphate 9-12 sulfiredoxin Arabidopsis thaliana 81-86 31770701-9 2019 The GTPase activity domain and ADP-ribosylation domain were conserved signature sequences of the eEF2 gene family. Adenosine Diphosphate 31-34 eukaryotic translation elongation factor 2 Gallus gallus 97-101 31704703-9 2019 alpha-tubulin mono-ADP-ribosylation levels were reduced in Tiparp-/- cells, suggesting the Tiparp plays a role in the mono-ADP-ribosylation of alpha-tubulin. Adenosine Diphosphate 14-22 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 59-65 31704703-9 2019 alpha-tubulin mono-ADP-ribosylation levels were reduced in Tiparp-/- cells, suggesting the Tiparp plays a role in the mono-ADP-ribosylation of alpha-tubulin. Adenosine Diphosphate 14-22 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 91-97 31704703-9 2019 alpha-tubulin mono-ADP-ribosylation levels were reduced in Tiparp-/- cells, suggesting the Tiparp plays a role in the mono-ADP-ribosylation of alpha-tubulin. Adenosine Diphosphate 118-126 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 59-65 31704703-9 2019 alpha-tubulin mono-ADP-ribosylation levels were reduced in Tiparp-/- cells, suggesting the Tiparp plays a role in the mono-ADP-ribosylation of alpha-tubulin. Adenosine Diphosphate 118-126 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 91-97 31704703-14 2019 Cytoskeletal components, such as alpha-tubulin, are key regulators of neuronal differentiation and cortical development, here we show that Tiparp is part of a complex that interacts with alpha-tubulin and plays a role in its mono-ADP-ribosylation. Adenosine Diphosphate 225-233 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 139-145 31704703-15 2019 Despite the mild phenotype presented by the Tiparp knockout mouse our findings reveal an important function of mono-ADP-ribosylation by this enzyme in the correct development of the cortex. Adenosine Diphosphate 111-119 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 44-50 31591378-0 2019 ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 104-129 31591378-12 2019 Taken together, our results indicate that P2Y12 is an important chemotaxis receptor, which triggers migration of macrophages towards nucleotide-rich, necrotic tumor areas, and modulates the inflammatory environment upon ADP binding. Adenosine Diphosphate 220-223 purinergic receptor P2Y12 Homo sapiens 42-47 31492816-3 2019 We found that, during TRiC ring closure, the CCT7 subunit moves first, responding to nucleotide binding; CCT4 is the last to bind ATP, serving as an ATP sensor; and CCT8 remains ADP-bound and is hardly involved in the ATPase-cycle in our experimental conditions; overall, yeast TRiC consumes nucleotide in a 2-ring positively coordinated manner. Adenosine Diphosphate 178-181 chaperonin-containing T-complex subunit CCT8 Saccharomyces cerevisiae S288C 165-169 31045292-5 2019 Additionally, we identify a missense variant (c.1963A>G), affecting a residue of the ATP-dependent helicase domain that is highly conserved between humans and yeast, with the resulting substitution (p.Thr655Ala) predicted to directly impact ATP/ADP (adenosine diphosphate) binding by DNA2. Adenosine Diphosphate 245-248 bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 Saccharomyces cerevisiae S288C 284-288 31168321-6 2019 Elevated levels of adenine-nucleotide pool "AXP" ([ATP] + [ADP] + [AMP]) and ATP content were observed by overexpression of ADE17, both under control condition and under acetic acid stress, and is consistent with the better growth of the recombinant yeast strain. Adenosine Diphosphate 59-62 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 Saccharomyces cerevisiae S288C 124-129 31000529-2 2019 At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5"-diphosphate (ADP) coupled with falling adenosine 5"-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. Adenosine Diphosphate 84-108 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 31000529-2 2019 At the cellular level, AMPK is activated by metabolic stresses that increase AMP or adenosine 5"-diphosphate (ADP) coupled with falling adenosine 5"-triphosphate (ATP) and acts to restore energy balance by choreographing a shift in metabolism in favour of energy-producing catabolic pathways while inhibiting non-essential anabolic processes. Adenosine Diphosphate 110-113 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 30948526-6 2019 Recognition of PBL2UMP is exclusively through RKS1, which interacts with ZAR1LRR PBL2UMP binding stabilizes the RKS1 activation segment, which sterically blocks ZAR1 adenosine diphosphate (ADP) binding. Adenosine Diphosphate 189-192 protein kinase 2A Arabidopsis thaliana 15-19 30948526-6 2019 Recognition of PBL2UMP is exclusively through RKS1, which interacts with ZAR1LRR PBL2UMP binding stabilizes the RKS1 activation segment, which sterically blocks ZAR1 adenosine diphosphate (ADP) binding. Adenosine Diphosphate 189-192 Protein kinase superfamily protein Arabidopsis thaliana 46-50 30948526-6 2019 Recognition of PBL2UMP is exclusively through RKS1, which interacts with ZAR1LRR PBL2UMP binding stabilizes the RKS1 activation segment, which sterically blocks ZAR1 adenosine diphosphate (ADP) binding. Adenosine Diphosphate 189-192 HOPZ-ACTIVATED RESISTANCE 1 Arabidopsis thaliana 73-77 30948526-6 2019 Recognition of PBL2UMP is exclusively through RKS1, which interacts with ZAR1LRR PBL2UMP binding stabilizes the RKS1 activation segment, which sterically blocks ZAR1 adenosine diphosphate (ADP) binding. Adenosine Diphosphate 189-192 Protein kinase superfamily protein Arabidopsis thaliana 112-116 30948526-6 2019 Recognition of PBL2UMP is exclusively through RKS1, which interacts with ZAR1LRR PBL2UMP binding stabilizes the RKS1 activation segment, which sterically blocks ZAR1 adenosine diphosphate (ADP) binding. Adenosine Diphosphate 189-192 HOPZ-ACTIVATED RESISTANCE 1 Arabidopsis thaliana 161-165 30673942-8 2019 In AIS patients, 46% had suboptimal response (< 30% MAAA inhibition) to aspirin and 80% of patients on P2Y12 therapy had high platelet reactivity (> 50% ADP-induced platelet aggregation). Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 106-111 29623826-3 2019 AMPK is a heterotrimeric protein complex regulated by AMP, ADP, and ATP allosterically. Adenosine Diphosphate 59-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 30445678-6 2018 P2Y12-inhibition was stronger in CANGRELOR compared to ORAL P2Y12 (adenosine diphosphate (ADP) (area under the curve (AUC)) 26.0 (5.9-71.6) vs. 160.9 (47.1-193.7)) at day 1. Adenosine Diphosphate 67-88 purinergic receptor P2Y12 Homo sapiens 0-5 30445678-6 2018 P2Y12-inhibition was stronger in CANGRELOR compared to ORAL P2Y12 (adenosine diphosphate (ADP) (area under the curve (AUC)) 26.0 (5.9-71.6) vs. 160.9 (47.1-193.7)) at day 1. Adenosine Diphosphate 67-88 purinergic receptor P2Y12 Homo sapiens 60-65 30445678-6 2018 P2Y12-inhibition was stronger in CANGRELOR compared to ORAL P2Y12 (adenosine diphosphate (ADP) (area under the curve (AUC)) 26.0 (5.9-71.6) vs. 160.9 (47.1-193.7)) at day 1. Adenosine Diphosphate 90-93 purinergic receptor P2Y12 Homo sapiens 0-5 30445678-6 2018 P2Y12-inhibition was stronger in CANGRELOR compared to ORAL P2Y12 (adenosine diphosphate (ADP) (area under the curve (AUC)) 26.0 (5.9-71.6) vs. 160.9 (47.1-193.7)) at day 1. Adenosine Diphosphate 90-93 purinergic receptor P2Y12 Homo sapiens 60-65 32431608-11 2020 5HD reduced the ADP-stimulated respiration in the HSP10 group (65.84 +- 3.3 nmol O2/min/mg PTN), ATP production (193.7 +- 12.1 mumol ATP/200mug PTN) and increased ROS in the 5-10-sP group (274.4 +- 21.7 nmol H2O2/200 mug PTN). Adenosine Diphosphate 16-19 pleiotrophin Rattus norvegicus 144-147 30222974-3 2018 P2Y12 receptors need to be situated in these domains to be able to conduct activation signaling by adenosine diphosphate (ADP). Adenosine Diphosphate 99-120 purinergic receptor P2Y12 Homo sapiens 0-5 30222974-3 2018 P2Y12 receptors need to be situated in these domains to be able to conduct activation signaling by adenosine diphosphate (ADP). Adenosine Diphosphate 122-125 purinergic receptor P2Y12 Homo sapiens 0-5 32431608-11 2020 5HD reduced the ADP-stimulated respiration in the HSP10 group (65.84 +- 3.3 nmol O2/min/mg PTN), ATP production (193.7 +- 12.1 mumol ATP/200mug PTN) and increased ROS in the 5-10-sP group (274.4 +- 21.7 nmol H2O2/200 mug PTN). Adenosine Diphosphate 16-19 pleiotrophin Rattus norvegicus 144-147 30199785-1 2018 P2Y12 receptor antagonists are a class of drugs that act on platelet P2Y12 receptors and inhibit adenosine diphosphate-induced platelet aggregation. Adenosine Diphosphate 97-118 purinergic receptor P2Y12 Homo sapiens 0-5 32155290-8 2020 Secondary ATP liberation induced by low level (50 nM) of exoATP was reduced by inhibiting ecto-ATPase-dependent ADP production with ARL67156, or blocking P2 receptors with suramin or PPADS, or with specific P2Y13 receptor antagonist MRS2211, or siRNA. Adenosine Diphosphate 112-115 purinergic receptor P2Y13 Rattus norvegicus 207-212 29891536-7 2018 Platelets from G6b-B diY/F mice were hyporesponsive to collagen, as a result of the significant reduction in the expression of the immunoreceptor tyrosine-based activation motif (ITAM)-containing collagen receptor complex GPVI-FcR gamma-chain, as well as thrombin, which could be partially rescued by costimulating the platelets with adenosine diphosphate. Adenosine Diphosphate 334-355 megakaryocyte and platelet inhibitory receptor G6b Mus musculus 15-18 30006350-10 2018 One of these proteins, ADP/ATP translocase 2 (ANT2), known to be involved in mitotic spindle formation, colocalized with miR-29b in perinuclear clusters independently of Argonaute 2. Adenosine Diphosphate 23-26 microRNA 29b-1 Homo sapiens 121-128 29991594-5 2018 Surprisingly, the modeling revealed that the catalytic properties of KIF3A and KIF3B/C were altered upon microtubule binding, yet each motor domain retained its relative intrinsic kinetics for ADP release and subsequent ATP binding and the nucleotide-promoted transitions thereafter. Adenosine Diphosphate 193-196 kinesin family member 3A Homo sapiens 69-74 30097648-3 2018 Here we present new crystal structures of mouse ADK (mADK) binary (mADK:ADO; 1.2 A) and ternary (mADK:ADO:ADP; 1.8 A) complexes. Adenosine Diphosphate 106-109 adenosine kinase Mus musculus 48-51 30097648-3 2018 Here we present new crystal structures of mouse ADK (mADK) binary (mADK:ADO; 1.2 A) and ternary (mADK:ADO:ADP; 1.8 A) complexes. Adenosine Diphosphate 106-109 adenosine kinase Mus musculus 53-57 30038627-2 2018 We have previously shown that chronic gating of P2X7 by ADP-ribosylation reduces the vitality and function of regulatory T cells and natural killer T cells that co-express high levels of ARTC2.2 and P2X7. Adenosine Diphosphate 56-59 ADP-ribosyltransferase 2a Mus musculus 187-192 30038627-6 2018 Injection of the ARTC2.2-blocking nanobody s+16a 30 min prior to organ harvesting effectively prevented ADP-ribosylation of P2X7 during cell preparation and thereby prevented NAD-induced cell death of the isolated Trm upon subsequent incubation at 37 C. Consequently, preserving Trm vitality by s+16a injection enabled a highly sensitive in vitro cytokine expression profile analyses of FACS sorted liver Trm. Adenosine Diphosphate 104-107 ADP-ribosyltransferase 2a Mus musculus 17-22 29688796-1 2018 How the absence of the major mitochondrial ADP/ATP carrier in yeast, Aac2p, results in a specific defect in cytochrome c oxidase (COX; complex IV) activity is a long-standing mystery. Adenosine Diphosphate 43-46 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 69-74 29455338-8 2018 In addition, adenosine induced an increase in proliferation and migration in PTC derived cells, whose effect was blocked by APCP, a non-hydrolysable ADP analogue, which is an inhibitor of CD73. Adenosine Diphosphate 149-152 5'-nucleotidase ecto Homo sapiens 188-192 30464037-4 2019 Biochemical characterization in Arabidopsis thaliana revealed that PAPST2 mediates the antiport of PAP, PAPS, ATP, and ADP. Adenosine Diphosphate 119-122 solute carrier family 35 member B3 Homo sapiens 67-73 30520735-4 2018 Here we present crystal structures of complexes of DinG bound to single-stranded DNA (ssDNA) in the presence and absence of an ATP analogue (ADP BeF3), that suggest a mechanism for 5"-3" translocation along the ssDNA substrate. Adenosine Diphosphate 141-144 ring finger protein 2 Homo sapiens 51-55 30359790-11 2018 CONCLUSION: Therefore, our results show that TNF-alpha negatively modulates ADP-induced aggregation via TNFR1/TNFR2 receptors by reducing cytosolic Ca++ levels and by inhibiting c-Src and fibrinogen receptor activation, which take place through cAMP- and cGMP-independent mechanisms. Adenosine Diphosphate 76-79 TNF receptor superfamily member 1B Rattus norvegicus 110-115 30423971-2 2018 Energy stress manifests as a drop in the ratio of adenosine triphosphate (ATP) to AMP/ADP, which activates AMPK"s kinase activity, allowing it to upregulate ATP-generating catabolic pathways and to reduce energy-consuming catabolic pathways and cellular programs. Adenosine Diphosphate 86-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 107-111 30423971-3 2018 AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. Adenosine Diphosphate 99-102 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 30423971-3 2018 AMPK senses the cellular energy state by competitive binding of the three adenine nucleotides AMP, ADP, and ATP to three sites in its gamma subunit, each, which in turn modulates the activity of AMPK"s kinase domain in its alpha subunit. Adenosine Diphosphate 99-102 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 195-199 30303204-1 2018 Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5"-nucleotidase (CD73) to immunosuppressive adenosine. Adenosine Diphosphate 134-137 5'-nucleotidase ecto Homo sapiens 181-201 30303204-1 2018 Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5"-nucleotidase (CD73) to immunosuppressive adenosine. Adenosine Diphosphate 134-137 5'-nucleotidase ecto Homo sapiens 203-207 30292134-13 2018 ADP induced an increase in phosphorylation of p38 and the effect was markedly inhibited by the p38 inhibitor SB203580. Adenosine Diphosphate 0-3 mitogen activated protein kinase 14 Rattus norvegicus 46-49 30292134-13 2018 ADP induced an increase in phosphorylation of p38 and the effect was markedly inhibited by the p38 inhibitor SB203580. Adenosine Diphosphate 0-3 mitogen activated protein kinase 14 Rattus norvegicus 95-98 30292134-14 2018 Similarly, NADPH also inhibited ADP-induced phosphorylation of p38. Adenosine Diphosphate 12-15 mitogen activated protein kinase 14 Rattus norvegicus 63-66 30012347-8 2018 After adding the direct ADP P2Y12 inhibitor cangrelor to blood samples from all 93 patients in vitro, residual ADP-inducible platelet reactivity correlated weakly with the platelet count (r = 0.26, P = 0.01), but the platelet count did not differ significantly between patients with and without HRPR ADP (396 x 109/L [316 - 644 x 109/L] vs 340 x 109/L [241 - 489 x 109/L]; P = 0.2). Adenosine Diphosphate 111-114 purinergic receptor P2Y12 Homo sapiens 28-33 29101112-6 2018 Germline DNA-repair mutations are more frequent in men with metastatic disease than previously thought, and these patients have a more favorable response to therapy with poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors. Adenosine Diphosphate 175-196 collagen type XI alpha 2 chain Homo sapiens 223-227 30154480-4 2018 Heterologous expression of SLC35B1 in E. coli reveals that SLC35B1 is highly specific for ATP and ADP and acts in antiport mode. Adenosine Diphosphate 98-101 solute carrier family 35 member B1 Homo sapiens 27-34 30154480-4 2018 Heterologous expression of SLC35B1 in E. coli reveals that SLC35B1 is highly specific for ATP and ADP and acts in antiport mode. Adenosine Diphosphate 98-101 solute carrier family 35 member B1 Homo sapiens 59-66 30154480-6 2018 Thus, human SLC35B1 may provide ATP to the ER and was named AXER (ATP/ADP exchanger in the ER membrane). Adenosine Diphosphate 70-73 solute carrier family 35 member B1 Homo sapiens 12-19 29968812-9 2018 P2Y12 and TPalpha, receptors for ADP and thromboxane A2, respectively, have been reported to be in platelet lipid rafts. Adenosine Diphosphate 33-36 purinergic receptor P2Y12 Homo sapiens 0-5 29205673-1 2018 AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. Adenosine Diphosphate 129-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 29205673-1 2018 AMP-activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. Adenosine Diphosphate 129-132 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 29407897-2 2018 Phosphoglycerate kinase (PGK), an enzyme that converts 1,3-bisphosphoglycerate and adenosine diphosphate to 3-phosphoglycerate and adenosine triphosphate, has two isozymes: PGK1 and PGK2. Adenosine Diphosphate 83-104 phosphoglycerate kinase 1 Mus musculus 173-177 32368161-1 2020 Background: High on-treatment ADP platelet reactivity (HPR) measured by VerifyNow P2Y12 assay (VN) is an established risk factor for ischemic events after percutaneous coronary intervention (PCI). Adenosine Diphosphate 30-33 purinergic receptor P2Y12 Homo sapiens 82-87 29350995-1 2018 P2Y12 belongs to a group of G protein-coupled (GPCR) purinergic receptors and is a receptor for adenosine diphosphate (ADP). Adenosine Diphosphate 96-117 purinergic receptor P2Y12 Homo sapiens 0-5 29350995-1 2018 P2Y12 belongs to a group of G protein-coupled (GPCR) purinergic receptors and is a receptor for adenosine diphosphate (ADP). Adenosine Diphosphate 119-122 purinergic receptor P2Y12 Homo sapiens 0-5 32264868-11 2020 CONCLUSIONS: EMPA and DAPA ameliorated lipotoxic damage in stearate-treated MAC, and reduced ADP-stimulated PLT activation, potentially via NHE-inhibition, thereby pointing to plaque stabilization and/or thrombosis inhibition as potential mechanism(s) involved in SGLT2i-mediated cardiovascular protection. Adenosine Diphosphate 93-96 solute carrier family 9 member C1 Homo sapiens 140-143 29468430-10 2018 P2Y12 inhibition was recorded by stimulation of platelet aggregation with adenosine diphosphate. Adenosine Diphosphate 74-95 purinergic receptor P2Y12 Homo sapiens 0-5 32007387-2 2020 AMP or adenosine diphosphate (ADP) levels rise during metabolic stress, such as during nutrient starvation, hypoxia and muscle contraction, and bind to AMPK to induce activity. Adenosine Diphosphate 7-28 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 152-156 29455645-1 2018 Originally identified as a metabolic enzyme that catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP in the glycolytic pathway, pyruvate kinase M2-type (PKM2) has been shown to exhibit novel biological activities in the nucleus and outside the cells. Adenosine Diphosphate 127-130 pyruvate kinase, muscle Mus musculus 158-187 32007387-2 2020 AMP or adenosine diphosphate (ADP) levels rise during metabolic stress, such as during nutrient starvation, hypoxia and muscle contraction, and bind to AMPK to induce activity. Adenosine Diphosphate 30-33 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 152-156 31808055-0 2020 ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 11-16 29153408-1 2018 Mammalian AMPK is known to be activated by falling cellular energy status, signaled by rising AMP/ATP and ADP/ATP ratios. Adenosine Diphosphate 106-109 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 10-14 29261292-10 2018 The primary finding of this work is that mono- versus multi-HAAs address different molecular targets, and the results are generally consistent with a model in which monoHAAs activate the PDC through GAPDH inhibition-mediated disruption in cellular metabolites, including altering ATP-to-ADP and NADH-to-NAD ratios. Adenosine Diphosphate 287-290 glyceraldehyde-3-phosphate dehydrogenase Cricetulus griseus 199-204 29358376-2 2018 Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two ADP-bound states of myosin-IB (myo1b) bound to actin, determined by cryo-electron microscopy. Adenosine Diphosphate 119-122 myosin IB Homo sapiens 139-148 29358376-2 2018 Here, we reveal the structural basis for force-sensing based on near-atomic resolution structures of one rigor and two ADP-bound states of myosin-IB (myo1b) bound to actin, determined by cryo-electron microscopy. Adenosine Diphosphate 119-122 myosin IB Homo sapiens 150-155 29358376-5 2018 This pointed-end orientation of the lever blocks ADP release by preventing the N-terminal subdomain from the pivoting required to open the nucleotide binding site, thus revealing how myo1b is inhibited by mechanical loads that restrain lever rotation. Adenosine Diphosphate 49-52 myosin IB Homo sapiens 183-188 29358376-6 2018 The lever of the second ADP state adopts a rigor-like orientation, stabilized by class-specific elements of myo1b. Adenosine Diphosphate 24-27 myosin IB Homo sapiens 108-113 29456511-5 2018 Under ATP and ADP stimulation the purinergic P2Y1 receptor (R) initiates platelet activation followed by the ADP-P2Y12R-mediated amplification. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 113-119 28913918-3 2018 ADP-induced aggregometry in whole blood classified 74% (95% confidence intervals 59-87%) of critically ill patients as poor responders (n = 43), and 65% (49-79%) responded poorly according to the vasodilator-stimulated phosphoprotein phosphorylation (VASP-P) assay. Adenosine Diphosphate 0-3 vasodilator stimulated phosphoprotein Homo sapiens 251-255 29401437-5 2018 By applying the law of total expectation to cargo binding durations in ADP, the kinesin-2 microtubule reattachment rate was shown to be fourfold faster than that of kinesin-1. Adenosine Diphosphate 71-74 kinesin family member 2A Homo sapiens 80-89 28921624-3 2018 METHODS: This was a single-centre, prospective, randomized clinical trial involving 60 hospitalized Adenosine Diphosphate (ADP) P2Y12 receptor inhibitor-naive patients with chronic kidney disease (CKD) (estimated glomerular filtration rate <60 ml min-1 1.73 m-2 ) and non-ST-elevation acute coronary syndromes (NSTE-ACS). Adenosine Diphosphate 100-121 purinergic receptor P2Y12 Homo sapiens 128-133 28921624-3 2018 METHODS: This was a single-centre, prospective, randomized clinical trial involving 60 hospitalized Adenosine Diphosphate (ADP) P2Y12 receptor inhibitor-naive patients with chronic kidney disease (CKD) (estimated glomerular filtration rate <60 ml min-1 1.73 m-2 ) and non-ST-elevation acute coronary syndromes (NSTE-ACS). Adenosine Diphosphate 123-126 purinergic receptor P2Y12 Homo sapiens 128-133 28511553-9 2018 The ADP test results were also significantly lower in patients treated with a P2Y12 inhibitor (control: 77.7 [21.7] U, P2Y12 inhibitor: 37.3 [20.4] U, P < .01). Adenosine Diphosphate 4-7 purinergic receptor P2Y12 Homo sapiens 78-83 28511553-9 2018 The ADP test results were also significantly lower in patients treated with a P2Y12 inhibitor (control: 77.7 [21.7] U, P2Y12 inhibitor: 37.3 [20.4] U, P < .01). Adenosine Diphosphate 4-7 purinergic receptor P2Y12 Homo sapiens 119-124 30097878-1 2018 Mouse T cells express the toxin-related ecto-ADP-ribosyltransferase ARTC2 that catalyzes the posttranslational ADP-ribosylation of cell surface proteins by transferring the ADP-ribose group of its substrate nicotinamide adenine dinucleotide (NAD+) to arginine residues of its target proteins. Adenosine Diphosphate 45-48 ADP-ribosyltransferase 2a Mus musculus 68-73 30097878-1 2018 Mouse T cells express the toxin-related ecto-ADP-ribosyltransferase ARTC2 that catalyzes the posttranslational ADP-ribosylation of cell surface proteins by transferring the ADP-ribose group of its substrate nicotinamide adenine dinucleotide (NAD+) to arginine residues of its target proteins. Adenosine Diphosphate 111-114 ADP-ribosyltransferase 2a Mus musculus 68-73 29296928-3 2017 In contrast, adenosine 5"-diphosphate (ADP)/P2Y12 signaling contributes to the accumulation of partially activated, loosely packed platelets in a shell overlying the core. Adenosine Diphosphate 13-37 purinergic receptor P2Y12 Homo sapiens 44-49 29296928-3 2017 In contrast, adenosine 5"-diphosphate (ADP)/P2Y12 signaling contributes to the accumulation of partially activated, loosely packed platelets in a shell overlying the core. Adenosine Diphosphate 39-42 purinergic receptor P2Y12 Homo sapiens 44-49 29199952-2 2017 Here we present cryo-EM structures of the unique minus-end directed myosin VI motor domain in rigor (4.6 A) and Mg-ADP (5.5 A) states bound to F-actin. Adenosine Diphosphate 112-118 myosin VI Homo sapiens 68-77 28753204-5 2017 Mechanistically, ASK1-JNK/p38 axis phosphorylates an ADP receptor P2Y12 at Thr345, which is required for the ADP-dependent sustained Akt activity that is vital to normal platelet functions. Adenosine Diphosphate 53-56 purinergic receptor P2Y12 Homo sapiens 66-71 29059240-1 2017 We studied the interaction between GroES and a single-ring mutant (SR1) of GroEL by the NMR titration of 15N-labeled GroES with SR1 at three different temperatures (20, 25 and 30 C) in the presence of 3 mM ADP in 100 mM KCl and 10 mM MgCl2 at pH 7.5. Adenosine Diphosphate 206-209 heat shock protein family E (Hsp10) member 1 Homo sapiens 35-40 29059240-5 2017 The binding was thus entropic with a positive entropy change (219 J/mol/K) and a positive enthalpy change (35 kJ/mol), and the binding constant was estimated at 1.9x105 M-1 at 25 C. The NMR titration in 3 mM ATP also indicated that the binding constant between GroES and SR1 increased more than tenfold as compared with the binding constant in 3 mM ADP. Adenosine Diphosphate 349-352 heat shock protein family E (Hsp10) member 1 Homo sapiens 261-266 28876503-4 2017 Dab2-pS723 regulated ADP release and integrin alphaIIbbeta3 activation in thrombin-treated platelets. Adenosine Diphosphate 21-24 DAB adaptor protein 2 Homo sapiens 0-4 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 91-112 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 91-112 fragile histidine triad diadenosine triphosphatase Homo sapiens 9-24 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 91-112 fragile histidine triad diadenosine triphosphatase Homo sapiens 150-154 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 114-117 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 114-117 fragile histidine triad diadenosine triphosphatase Homo sapiens 9-24 28643453-2 2017 Fhit has Ap3 A hydrolase activity and cleaves Ap3 A into adenosine monophosphate (AMP) and adenosine diphosphate (ADP); this is believed to terminate Fhit-mediated signaling. Adenosine Diphosphate 114-117 fragile histidine triad diadenosine triphosphatase Homo sapiens 150-154 28523947-1 2018 The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. Adenosine Diphosphate 15-18 purinergic receptor P2Y12 Homo sapiens 76-81 28523947-6 2018 These results suggest that inhibition of P2Y12 with MRS2395 may act in concert with PAR-1 signaling and result in the aberrant release of ADP by platelet dense granules, thus reducing or counteracting the anticipated anti-platelet efficacy of this inhibitor. Adenosine Diphosphate 138-141 purinergic receptor P2Y12 Homo sapiens 41-46 29749375-6 2018 Based on the rigid body movements of actin and the three cofilin-actin interfaces, we propose models for the cooperative binding of cofilin to actin, preferential binding of cofilin to ADP-bound actin filaments and cofilin-mediated severing of actin filaments. Adenosine Diphosphate 185-188 cofilin 1 Homo sapiens 57-64 29749375-6 2018 Based on the rigid body movements of actin and the three cofilin-actin interfaces, we propose models for the cooperative binding of cofilin to actin, preferential binding of cofilin to ADP-bound actin filaments and cofilin-mediated severing of actin filaments. Adenosine Diphosphate 185-188 cofilin 1 Homo sapiens 132-139 29749375-6 2018 Based on the rigid body movements of actin and the three cofilin-actin interfaces, we propose models for the cooperative binding of cofilin to actin, preferential binding of cofilin to ADP-bound actin filaments and cofilin-mediated severing of actin filaments. Adenosine Diphosphate 185-188 cofilin 1 Homo sapiens 132-139 29749375-6 2018 Based on the rigid body movements of actin and the three cofilin-actin interfaces, we propose models for the cooperative binding of cofilin to actin, preferential binding of cofilin to ADP-bound actin filaments and cofilin-mediated severing of actin filaments. Adenosine Diphosphate 185-188 cofilin 1 Homo sapiens 132-139 29575062-0 2018 Restored response to ADP downstream of purinergic P2Y12 receptor in apheresis platelets after pathogen-reducing xenon flash treatment. Adenosine Diphosphate 21-24 purinergic receptor P2Y12 Homo sapiens 50-55 29496264-1 2018 EFA6 (exchange factor for ARF6) activates Arf6 (ADP ribosylation factor 6) by exchanging ADP to ATP and the resulting activated form of Arf6 is involved in the membrane trafficking and actin remodeling of cells. Adenosine Diphosphate 48-51 pleckstrin and Sec7 domain containing Mus musculus 0-4 29496264-1 2018 EFA6 (exchange factor for ARF6) activates Arf6 (ADP ribosylation factor 6) by exchanging ADP to ATP and the resulting activated form of Arf6 is involved in the membrane trafficking and actin remodeling of cells. Adenosine Diphosphate 48-51 pleckstrin and Sec7 domain containing Mus musculus 6-30 28777435-5 2018 The activation of P2Y1 receptor by ADP leads to activation of intracellular transduction pathways involving [Ca2+ ]i , PKC-delta/PKC-alpha, and MAPKs, ERK1/2 and JNK1/2. Adenosine Diphosphate 35-38 protein kinase C delta Homo sapiens 119-128 28777435-7 2018 Inhibition of ZL55 cell proliferation by ADP was completely reversed by inhibiting MEK1/2, or JNK1/2, or PKC-delta, and PKC-alpha. Adenosine Diphosphate 41-44 protein kinase C delta Homo sapiens 105-114 29321137-7 2018 Proximity ligation and coimmunoprecipitation assays showed that ceramide depletion reduced association of tubulin with voltage-dependent anion channel 1 (VDAC1), an interaction known to block mitochondrial ADP/ATP transport. Adenosine Diphosphate 206-209 voltage dependent anion channel 1 Homo sapiens 119-152 29321137-7 2018 Proximity ligation and coimmunoprecipitation assays showed that ceramide depletion reduced association of tubulin with voltage-dependent anion channel 1 (VDAC1), an interaction known to block mitochondrial ADP/ATP transport. Adenosine Diphosphate 206-209 voltage dependent anion channel 1 Homo sapiens 154-159 30202779-5 2018 Poor agreement between prevention by adenosine diphosphate (ADP) of PGE1-induced cAMP-mediated VASP phosphorylation and ADP induced aggregation assessed by Light Transmittance Aggregometry was found. Adenosine Diphosphate 37-58 vasodilator stimulated phosphoprotein Homo sapiens 95-99 30202779-5 2018 Poor agreement between prevention by adenosine diphosphate (ADP) of PGE1-induced cAMP-mediated VASP phosphorylation and ADP induced aggregation assessed by Light Transmittance Aggregometry was found. Adenosine Diphosphate 60-63 vasodilator stimulated phosphoprotein Homo sapiens 95-99 29415503-7 2018 After ATP is hydrolyzed to Adenosine diphosphate (ADP), HSP60 released the HSP10 and the dissociation of the double-ring to single-rings occurred. Adenosine Diphosphate 27-48 heat shock protein family E (Hsp10) member 1 Homo sapiens 75-80 29415503-7 2018 After ATP is hydrolyzed to Adenosine diphosphate (ADP), HSP60 released the HSP10 and the dissociation of the double-ring to single-rings occurred. Adenosine Diphosphate 50-53 heat shock protein family E (Hsp10) member 1 Homo sapiens 75-80 29207652-7 2017 IC50 of IQCA-TAVV against platelet aggregation induced by arachidonic acid, adenosine diphosphate and platelet activating factor fell within a range of 0.13 nM to 0.30 nM. Adenosine Diphosphate 76-97 IQ motif containing with AAA domain Mus musculus 8-17 31808055-0 2020 ADP exerts P2Y12 -dependent and P2Y12 -independent effects on primary human T cell responses to stimulation. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 32-37 31808055-7 2020 We found that ADP affects T cell responses in term of cell activity and receptor expression through both P2Y12-dependent and P2Y12-independent pathways and other responses (cytokine secretion) primarily through P2Y12 -independent pathways. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 105-110 31808055-7 2020 We found that ADP affects T cell responses in term of cell activity and receptor expression through both P2Y12-dependent and P2Y12-independent pathways and other responses (cytokine secretion) primarily through P2Y12 -independent pathways. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 125-130 31808055-7 2020 We found that ADP affects T cell responses in term of cell activity and receptor expression through both P2Y12-dependent and P2Y12-independent pathways and other responses (cytokine secretion) primarily through P2Y12 -independent pathways. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 125-130 31931718-11 2020 In addition, SAA decreased the expressions of PAC-1 and CD62p, which were enhanced by ADP and thrombin (all P < 0.01). Adenosine Diphosphate 86-89 dual specificity phosphatase 2 Homo sapiens 46-51 29322294-2 2018 Platelet activation is largely mediated through ADP engagement of purinergic P2Y12 receptors on platelets. Adenosine Diphosphate 48-51 purinergic receptor P2Y12 Homo sapiens 77-82 31770590-6 2020 Functionally, ITI-214 inhibited ADP-induced migration of BV2 cells through a P2Y12-receptor-dependent pathway, possibly due to increases in the extent of cAMP and VASP phosphorylation downstream of receptor activation. Adenosine Diphosphate 32-35 vasodilator-stimulated phosphoprotein Mus musculus 163-167 30343298-8 2018 In preterm infants, platelet activation with adenosine diphosphate in the presence of a high surfactant concentration (0.5 mg/mL) resulted in increased PAC-1 binding and no change in P-selectin expression. Adenosine Diphosphate 45-66 dual specificity phosphatase 2 Homo sapiens 152-157 31546169-4 2020 A combination of biochemical, biophysical, crystallographic and cell biology approaches revealed a new and, to our knowledge, unique mode of Aurora A inhibition by CoA, involving selective binding of the ADP moiety of CoA to the ATP binding pocket and covalent modification of Cys290 in the activation loop by the thiol group of the pantetheine tail. Adenosine Diphosphate 204-207 aurora kinase A Homo sapiens 141-149 29171876-1 2018 BACKGROUND: Anaemic patients undergoing angioplasty and stenting are at an increased risk of ischaemic events, which may be caused by an inadequate response to antiplatelet therapy with adenosine diphosphate (ADP) P2Y12 inhibitors. Adenosine Diphosphate 209-212 purinergic receptor P2Y12 Homo sapiens 214-219 29171876-7 2018 Moreover, by LTA maximal aggregation in response to ADP was significantly higher in patients with anaemia in both groups (both P < .05), and anaemic patients in group 1 had a significantly higher on-treatment platelet reactivity by the VerifyNow P2Y12 assay and the Impact-R than those without anaemia (both P < .001). Adenosine Diphosphate 52-55 purinergic receptor P2Y12 Homo sapiens 249-254 31472174-8 2019 In line with these findings, the decrease in cytosolic ATP/ADP ratio caused by oligomycin was more pronounced in control than in Aralar-KO neurons, but no differences were observed with iodoacetate. Adenosine Diphosphate 59-62 solute carrier family 25 member 12 Homo sapiens 129-135 28300459-4 2017 Activation-dependent platelet surface marker expression of PAC-1 (binds to GPIIb/IIIa surface receptors on activated platelets) and CD62P (marker for P-selectin released from activated degranulated platelets) was assessed in adenosine diphosphate (ADP)-stimulated platelets using flow cytometry. Adenosine Diphosphate 225-246 dual specificity phosphatase 2 Homo sapiens 59-64 31636125-0 2019 The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP BeF3 - and transition state analogs. Adenosine Diphosphate 92-100 chromodomain helicase DNA binding protein 1 Homo sapiens 4-8 29184112-10 2017 In concordance, ARTC2.1 induction in WT microglia and subsequent cell surface ADP-ribosylation significantly reduced the phagocytosis of IgG-coated latex beads, which was unimpaired in NAD+/DTT treated microglia from ARTC2.1-/- mice. Adenosine Diphosphate 78-81 immunoglobulin heavy variable V1-62 Mus musculus 137-140 31636125-4 2019 We found that Chd1-nucleosome complexes formed in nucleotide-free or ADP conditions were relatively unstable and dissociated within 30 sec, whereas those with the non-hydrolyzable ATP analog AMP-PNP had a mean lifetime of 4.8 +- 0.7 min. Adenosine Diphosphate 69-72 chromodomain helicase DNA binding protein 1 Homo sapiens 14-18 31636125-5 2019 Chd1-nucleosome complexes were remarkably stable with ADP BeF3- and the transition state analogs ADP AlFX and ADP MgFX, being resistant to competitor nucleosome over a 24 hr period. Adenosine Diphosphate 54-62 chromodomain helicase DNA binding protein 1 Homo sapiens 0-4 29209319-1 2017 The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. Adenosine Diphosphate 119-122 5'-nucleotidase ecto Homo sapiens 25-29 31636125-5 2019 Chd1-nucleosome complexes were remarkably stable with ADP BeF3- and the transition state analogs ADP AlFX and ADP MgFX, being resistant to competitor nucleosome over a 24 hr period. Adenosine Diphosphate 54-57 chromodomain helicase DNA binding protein 1 Homo sapiens 0-4 31636125-5 2019 Chd1-nucleosome complexes were remarkably stable with ADP BeF3- and the transition state analogs ADP AlFX and ADP MgFX, being resistant to competitor nucleosome over a 24 hr period. Adenosine Diphosphate 110-118 chromodomain helicase DNA binding protein 1 Homo sapiens 0-4 31636125-7 2019 The ADP BeF3 --stabilized complex did not require the Chd1 DNA-binding domain nor the histone H4 tail, and appeared relatively insensitive to sequence differences on either side of the Widom 601 sequence. Adenosine Diphosphate 4-12 chromodomain helicase DNA binding protein 1 Homo sapiens 54-58 31652269-4 2019 The two main enzymes responsible for generating adenosine in the microenvironment are the ectonucleotidases CD39 and CD73, the former utilizes both ATP and ADP and produces AMP while the latter utilizes AMP and generates adenosine. Adenosine Diphosphate 156-159 5'-nucleotidase ecto Homo sapiens 117-121 28928091-2 2017 To this end, adenosine diphosphate (ADP) is an important platelet activator that acts by binding to the G-protein coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 13-34 purinergic receptor P2Y12 Homo sapiens 131-136 28928091-2 2017 To this end, adenosine diphosphate (ADP) is an important platelet activator that acts by binding to the G-protein coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 36-39 purinergic receptor P2Y12 Homo sapiens 131-136 28928091-5 2017 Our in vitro studies revealed that the P2Y12Ab could effectively inhibit aggregation induced by ADP, as well as that triggered by the thromboxane receptor agonist U46619. Adenosine Diphosphate 96-99 purinergic receptor P2Y12 Homo sapiens 39-44 31624289-5 2019 Computerized simulation demonstrated that these HuscFvs used several residues in their complementarity-determining regions (CDRs) to form contact interfaces with the critical residues in ETA-catalytic domain essential for ADP-ribosylation of eukaryotic elongation factor 2, which should consequently rescue ETA-exposed-cells from apoptosis. Adenosine Diphosphate 222-225 endothelin receptor type A Homo sapiens 187-190 28939772-7 2017 Our experiments suggest that an ADP-driven downward movement of the p97 N-terminal domain dislodges ataxin3 by inducing a steric clash between the D1-domain and ataxin3"s C terminus. Adenosine Diphosphate 32-35 valosin containing protein Homo sapiens 68-71 29064388-7 2017 Furthermore, we demonstrate that platelet-derived ADP and ATP regulate Slug and CDD expression in pancreatic cancer cells. Adenosine Diphosphate 50-53 cytidine deaminase Homo sapiens 80-83 27848264-2 2017 We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be prevented by inhibition of the ADP P2Y12 receptor. Adenosine Diphosphate 53-56 purinergic receptor P2Y12 Homo sapiens 198-203 27885904-11 2017 A proportion of P2Y12-inhibitor responsive patients according to VerifyNow, displayed normal fibrinogen binding assessed with flow cytometry after stimulation with PAR-agonists or CRP despite full inhibition of the response to ADP, indicating suboptimal platelet inhibition. Adenosine Diphosphate 227-230 purinergic receptor P2Y12 Homo sapiens 16-21 28800362-0 2017 Nucleotide transmitters ATP and ADP mediate intercellular calcium wave communication via P2Y12/13 receptors among BV-2 microglia. Adenosine Diphosphate 32-35 purinergic receptor P2Y12 Homo sapiens 89-94 28800362-11 2017 Taken together, these results demonstrated that the nucleotides ATP and ADP were predominant signal transmitters in mechanical stimulation-induced ICW communication through acting on P2Y12/13 receptors in BV-2 microglia. Adenosine Diphosphate 72-75 purinergic receptor P2Y12 Homo sapiens 183-188 31624289-5 2019 Computerized simulation demonstrated that these HuscFvs used several residues in their complementarity-determining regions (CDRs) to form contact interfaces with the critical residues in ETA-catalytic domain essential for ADP-ribosylation of eukaryotic elongation factor 2, which should consequently rescue ETA-exposed-cells from apoptosis. Adenosine Diphosphate 222-225 endothelin receptor type A Homo sapiens 307-310 31614656-6 2019 Although PARP1 was found at BRG1 positive/H3K27ac negative promoters of highly expressed genes in a transformed breast cancer cell line, its transcriptional activity was limited to genes simultaneously controlled by BRG1 and EP300, indicating that the ADP-ribosylation of EP300 plays a dominant role in the regulation of BRG1-EP300-driven transcription. Adenosine Diphosphate 252-255 E1A binding protein p300 Homo sapiens 272-277 28347874-6 2017 While no significant increase in CREB phosphorylation is observed with the P2Y1 receptor agonist MRS2365, ADP-induced phosphorylation of CREB is blocked by the P2Y13 receptor selective antagonist MRS2211, but not by MRS2179 or PSB0739, two antagonists of the P2Y1 and P2Y12 receptors, respectively, suggesting that ADP-induced CREB phosphorylation is mediated by P2Y13 receptors. Adenosine Diphosphate 106-109 purinergic receptor P2Y1 Gallus gallus 75-79 28347874-6 2017 While no significant increase in CREB phosphorylation is observed with the P2Y1 receptor agonist MRS2365, ADP-induced phosphorylation of CREB is blocked by the P2Y13 receptor selective antagonist MRS2211, but not by MRS2179 or PSB0739, two antagonists of the P2Y1 and P2Y12 receptors, respectively, suggesting that ADP-induced CREB phosphorylation is mediated by P2Y13 receptors. Adenosine Diphosphate 106-109 purinergic receptor P2Y1 Gallus gallus 160-164 28280103-11 2017 Four SNPs-rs2104543, rs12772169, rs1998591 and rs1042194-within CYP2C18 were in high LD, and the genetic polymorphisms had a significant impact on the TEG parameters maximal clot strength (MAThrombin) and ADP-induced platelet-fibrin clot strength (MAADP). Adenosine Diphosphate 205-208 cytochrome P450 family 2 subfamily C member 18 Homo sapiens 64-71 31614656-6 2019 Although PARP1 was found at BRG1 positive/H3K27ac negative promoters of highly expressed genes in a transformed breast cancer cell line, its transcriptional activity was limited to genes simultaneously controlled by BRG1 and EP300, indicating that the ADP-ribosylation of EP300 plays a dominant role in the regulation of BRG1-EP300-driven transcription. Adenosine Diphosphate 252-255 E1A binding protein p300 Homo sapiens 272-277 28637879-9 2017 P2Y12 expression correlates with ADP-induced platelet aggregation (r=0.89, P<0.01). Adenosine Diphosphate 33-36 purinergic receptor P2Y12 Homo sapiens 0-5 31614656-7 2019 In conclusion, PARP1 directs the transcription of some proliferation and DNA repair genes in breast cancer cells by the ADP-ribosylation of EP300, thereby causing its activation and marking nucleosomes for displacement by BRG1. Adenosine Diphosphate 120-123 E1A binding protein p300 Homo sapiens 140-145 28442572-7 2017 Moreover, oxidative stress (ADP, NADPH, and Fe3+) resulted in the robust production of oxidized CLs in intact mitochondria from iPLA2gamma-/- mice. Adenosine Diphosphate 28-31 patatin-like phospholipase domain containing 8 Mus musculus 128-138 31614656-7 2019 In conclusion, PARP1 directs the transcription of some proliferation and DNA repair genes in breast cancer cells by the ADP-ribosylation of EP300, thereby causing its activation and marking nucleosomes for displacement by BRG1. Adenosine Diphosphate 120-123 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 222-226 31265325-7 2019 Exercise training reversed the decline in maximal respiratory capacity independent of PGC-1alpha, whereas exercise training rescued the age-related mitochondrial network fragmentation and the impaired submaximal ADP-stimulated respiration in a PGC-1alpha-dependent manner. Adenosine Diphosphate 212-215 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 244-254 27862653-2 2017 Central players in adenosine signaling are the ectonucleotidases CD39 and CD73, which convert ADP/ATP to AMP and AMP to adenosine, respectively. Adenosine Diphosphate 94-97 5'-nucleotidase ecto Homo sapiens 74-78 28723898-2 2017 Glucose deprivation activates AMP-activated protein kinase (AMPK), but it is unclear whether this activation occurs solely via changes in AMP or ADP, the classical activators of AMPK. Adenosine Diphosphate 145-148 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 178-182 28723898-3 2017 Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and intracellular FBP decrease. Adenosine Diphosphate 25-28 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 65-69 28723898-3 2017 Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and intracellular FBP decrease. Adenosine Diphosphate 25-28 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 145-149 28347874-9 2017 While no increase in [3H]-thymidine incorporation is observed with the P2Y1 receptor agonist MRS2365, both MRS2179 and MRS2211 prevent ADP-mediated increase in [3H]-thymidine incorporation, but not progenitor"s survival, suggesting that both P2Y1 and P2Y13 receptor subtypes are involved in ADP-induced cell proliferation. Adenosine Diphosphate 135-138 purinergic receptor P2Y1 Gallus gallus 242-246 28562105-3 2017 Areas covered: The oral thienopyridine, prasugrel hydrochloride, irreversibly inhibits the P2Y12 receptors, inhibiting ADP-dependent platelet activation. Adenosine Diphosphate 119-122 purinergic receptor P2Y12 Homo sapiens 91-96 31265325-8 2019 Furthermore, lack of PGC-1alpha was associated with altered phosphorylation and carbonylation of the inner mitochondrial membrane ADP/ATP exchanger adenine nucleotide translocase 1. Adenosine Diphosphate 130-133 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 21-31 28630657-1 2017 Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. Adenosine Diphosphate 0-21 ADP ribosylation factor like GTPase 11 Homo sapiens 78-84 28630657-1 2017 Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. Adenosine Diphosphate 23-26 ADP ribosylation factor like GTPase 11 Homo sapiens 78-84 28360103-0 2017 Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. Adenosine Diphosphate 55-58 valosin containing protein Homo sapiens 13-39 28360103-0 2017 Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. Adenosine Diphosphate 55-58 valosin containing protein Homo sapiens 41-44 28115185-0 2017 Plasma kallikrein enhances platelet aggregation response by subthreshold doses of ADP. Adenosine Diphosphate 82-85 kallikrein B1 Homo sapiens 0-17 28115185-1 2017 Human plasma kallikrein (huPK) potentiates platelet responses to subthreshold doses of ADP, although huPK itself, does not induce platelet aggregation. Adenosine Diphosphate 87-90 kallikrein B1 Homo sapiens 6-23 31265325-9 2019 In conclusion, the present study provides evidence that PGC-1alpha regulates submaximal ADP-stimulated respiration, ROS emission, and mitochondrial network structure in mouse skeletal muscle during aging and exercise training. Adenosine Diphosphate 88-91 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 56-66 28115185-9 2017 Formation of plasma kallikrein lowers the threshold for ADP-induced platelet activation. Adenosine Diphosphate 56-59 kallikrein B1 Homo sapiens 13-30 31376607-2 2019 Activation of P2Y12 receptors by ADP causes Gi-protein-mediated inhibition of adenylate cyclase (AC), thus limiting platelet response to anti-aggregatory effect of prostacyclin (PGI2). Adenosine Diphosphate 33-36 purinergic receptor P2Y12 Homo sapiens 14-19 28232179-2 2017 AMPK responds to changes in intracellular adenine nucleotide levels, being activated by an increase in AMP/ADP relative to ATP. Adenosine Diphosphate 107-110 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 28255814-2 2017 Adenosine diphosphate (ADP) activated P2Y12 receptor also plays a key role in platelet activation and aggregation. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 38-43 28255814-2 2017 Adenosine diphosphate (ADP) activated P2Y12 receptor also plays a key role in platelet activation and aggregation. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 38-43 28383427-2 2017 Clopidogrel targets the platelet membrane receptor P2RY12 to inhibit platelet aggregation via adenosine diphosphate (ADP). Adenosine Diphosphate 94-115 purinergic receptor P2Y12 Homo sapiens 51-57 28383427-2 2017 Clopidogrel targets the platelet membrane receptor P2RY12 to inhibit platelet aggregation via adenosine diphosphate (ADP). Adenosine Diphosphate 117-120 purinergic receptor P2Y12 Homo sapiens 51-57 28190975-5 2017 Reactivity to ADP or oral bacteria was assessed by flow cytometric analysis of membrane markers (binding of PAC-1, P-selectin, CD63) and platelet-leukocyte complex formation. Adenosine Diphosphate 14-17 dual specificity phosphatase 2 Homo sapiens 108-113 28146060-1 2017 Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. Adenosine Diphosphate 216-219 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-48 28146060-1 2017 Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. Adenosine Diphosphate 216-219 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 50-54 27929199-5 2017 Gremlin-1 release upon activation with ADP, CRP, and TRAP was detected as enhanced surface expression; also in activated platelet supernatant as detected by Western Blot following CRP activation and by ELISA upon activation with ADP, CRP, PAR-1, and PAR4 agonist. Adenosine Diphosphate 39-42 Prader Willi/Angelman region RNA 4 Homo sapiens 250-254 27628007-2 2017 P2Y12 receptor is physiologically activated by ADP and inhibits adenyl cyclase (AC) to decrease cyclic AMP (cAMP) level, resulting in platelet aggregation. Adenosine Diphosphate 47-50 purinergic receptor P2Y12 Homo sapiens 0-5 28815513-2 2017 P2Y13 is one of the latest P2Y receptors identified, a novel member of the Gi-coupled P2Y receptor subfamily that responds to ADP, together with P2Y12 and P2Y14. Adenosine Diphosphate 126-129 purinergic receptor P2Y13 Homo sapiens 0-5 28637952-6 2017 Our results showed that addition of HSP72 increased platelet aggregation in the presence of low concentrations of ADP, collagen, TRAP-6, ristocetin, and arachidonic acid. Adenosine Diphosphate 114-117 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 36-41 28637952-7 2017 Increased platelet aggregation stimulated by ADP and HSP72 was reduced by the co-addition of anti-HSP72 antibodies. Adenosine Diphosphate 45-48 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 98-103 28344879-1 2017 CD39 and CD73 are surface-expressed ectonucleotidases that hydrolyze ATP in a highly regulated, serial manner into ADP, AMP and adenosine. Adenosine Diphosphate 115-118 5'-nucleotidase ecto Homo sapiens 9-13 27589852-12 2016 However, when ADP was used as a substrate, there was no inhibition of ATP hydrolysis showing the possibility of ATP diphosphohydrolase activity. Adenosine Diphosphate 14-17 ATP diphosphohydrolase Leishmania donovani 112-134 27740874-3 2016 Ticagrelor is a reversibly binding oral P2Y12 receptor blocker that mediates potent inhibition of adenosine diphosphate-induced platelet function. Adenosine Diphosphate 98-119 purinergic receptor P2Y12 Homo sapiens 40-45 28293755-3 2017 Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition. Adenosine Diphosphate 88-91 prolyl endopeptidase Homo sapiens 202-205 28293755-3 2017 Quotient velocity plot calculated from the Zn-inhibition curves showed that Zn2+ as a ZnADP complex acted as competitive and uncompetitive inhibitors of the enzyme with respect to the substrate ADP and PEP, respectively: Zn2+ forms a ZnADP complex, which may bind to the ADP-binding site of the free enzyme with the Ki value of 1.4 muM causing competitive inhibition, or to the ADP-site of the enzyme-PEP complex with 2.6 muM resulting in uncompetitive inhibition. Adenosine Diphosphate 88-91 prolyl endopeptidase Homo sapiens 401-404 27755650-3 2017 Ventricular myofibroblasts also express ADP-sensitive P2Y1 , P2Y12 , and P2Y13 receptors as demonstrated by immunofluorescence confocal microscopy and western blot analysis, but little information exists on ADP effects in these cells. Adenosine Diphosphate 40-43 purinergic receptor P2Y13 Rattus norvegicus 73-78 28144998-4 2017 ADP acting on P2Y12 receptors induce process extension of microglia thereby attracting microglia to the site of adenosine tri-phosphate/ADP leaking or release. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 14-19 28144998-4 2017 ADP acting on P2Y12 receptors induce process extension of microglia thereby attracting microglia to the site of adenosine tri-phosphate/ADP leaking or release. Adenosine Diphosphate 136-139 purinergic receptor P2Y12 Homo sapiens 14-19 28144998-10 2017 These data indicate that microglial P2Y12 receptors are utilized to trigger an acute inflammatory response in microglia via rapid CCL3 induction after ADP stimulation. Adenosine Diphosphate 151-154 purinergic receptor P2Y12 Homo sapiens 36-41 28337254-4 2017 In times of energy deficit, AMPK is allosterically modified by the binding of increased levels of AMP and ADP, making it a target of specific AMPK kinases (AMPKKs). Adenosine Diphosphate 106-109 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 28-32 28337254-4 2017 In times of energy deficit, AMPK is allosterically modified by the binding of increased levels of AMP and ADP, making it a target of specific AMPK kinases (AMPKKs). Adenosine Diphosphate 106-109 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 142-146 28082199-0 2017 Ric-8A-mediated stabilization of the trimeric G protein subunit Galphai is inhibited by pertussis toxin-catalyzed ADP-ribosylation. Adenosine Diphosphate 114-117 RIC8 guanine nucleotide exchange factor A Homo sapiens 0-6 27906627-2 2016 Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5"-nucleotidase (CD73) convert extracellular nucleotides in a sequential order: ATP to ADP, AMP, and then to adenosine. Adenosine Diphosphate 152-155 5'-nucleotidase ecto Homo sapiens 60-80 27906627-2 2016 Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5"-nucleotidase (CD73) convert extracellular nucleotides in a sequential order: ATP to ADP, AMP, and then to adenosine. Adenosine Diphosphate 152-155 5'-nucleotidase ecto Homo sapiens 82-86 27730346-5 2016 The incubation of WRAT in the presence of hSTC-1 maintained the ADP/ATP ratio close to the control group. Adenosine Diphosphate 64-67 stanniocalcin 1 Homo sapiens 42-48 27605392-1 2016 Ticagrelor is an antagonist of the platelet P2Y12 receptor for ADP, approved for the prevention of thromboembolic events in patients with acute coronary syndrome. Adenosine Diphosphate 63-66 purinergic receptor P2Y12 Homo sapiens 44-49 26516174-0 2016 Inhibition of the platelet P2Y12 receptor for adenosine diphosphate does not impair the capacity of platelet to synthesize thromboxane A2. Adenosine Diphosphate 46-67 purinergic receptor P2Y12 Homo sapiens 27-41 26516174-1 2016 AIMS: Patients with acute coronary syndromes (ACSs) are treated with acetylsalicylic acid (ASA) and antagonists of the P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP). Adenosine Diphosphate 147-168 purinergic receptor P2Y12 Homo sapiens 119-133 26516174-1 2016 AIMS: Patients with acute coronary syndromes (ACSs) are treated with acetylsalicylic acid (ASA) and antagonists of the P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP). Adenosine Diphosphate 147-168 purinergic receptor P2Y12 Homo sapiens 135-141 26516174-1 2016 AIMS: Patients with acute coronary syndromes (ACSs) are treated with acetylsalicylic acid (ASA) and antagonists of the P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP). Adenosine Diphosphate 170-173 purinergic receptor P2Y12 Homo sapiens 119-133 26516174-1 2016 AIMS: Patients with acute coronary syndromes (ACSs) are treated with acetylsalicylic acid (ASA) and antagonists of the P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP). Adenosine Diphosphate 170-173 purinergic receptor P2Y12 Homo sapiens 135-141 31376607-3 2019 However, P2Y12 blockade reverses this ADP-induced suppression of the platelet PGI2/AC signaling pathway. Adenosine Diphosphate 38-41 purinergic receptor P2Y12 Homo sapiens 9-14 31624788-1 2019 Antiplatelet therapy through inhibition of the adenosine diphosphate (ADP)/P2Y12 pathway is commonly used in the treatment of acute coronary syndrome (ACS). Adenosine Diphosphate 47-68 purinergic receptor P2Y12 Homo sapiens 75-80 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 46-67 AFG3-like AAA ATPase 2 Mus musculus 82-85 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 69-72 AFG3-like AAA ATPase 2 Mus musculus 82-85 31624788-1 2019 Antiplatelet therapy through inhibition of the adenosine diphosphate (ADP)/P2Y12 pathway is commonly used in the treatment of acute coronary syndrome (ACS). Adenosine Diphosphate 70-73 purinergic receptor P2Y12 Homo sapiens 75-80 31624788-5 2019 In vitro inhibition of the ADP pathway in healthy control platelets reduced both pCD40L and rCD40L levels. Adenosine Diphosphate 27-30 CD40 ligand Rattus norvegicus 92-98 31333668-9 2019 Frequency of FcgammaRIII+ AMs showed a strong trend toward correlation with SIV-specific ADP, and at 2-wpi FcgammaRIII expression negatively correlated with viral load (r = -0.6819; p = 0.0013), suggesting a contribution to viremia control. Adenosine Diphosphate 89-92 low affinity immunoglobulin gamma Fc region receptor III-A Macaca mulatta 13-24 27062501-8 2016 We sought to determine the role in this process of the AMP-activated protein kinase (AMPK), which is intimately coupled to mitochondrial function due to its activation by LKB1-dependent phosphorylation in response to increases in the cellular AMP:ATP and/or ADP:ATP ratios. Adenosine Diphosphate 258-261 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 55-83 27062501-8 2016 We sought to determine the role in this process of the AMP-activated protein kinase (AMPK), which is intimately coupled to mitochondrial function due to its activation by LKB1-dependent phosphorylation in response to increases in the cellular AMP:ATP and/or ADP:ATP ratios. Adenosine Diphosphate 258-261 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 85-89 31333668-12 2019 PD-1 blockade enhanced SIV-specific ADP by AMs from chronic infection indicating that the PD-1/PD-L2 pathway may modulate functional activity of AMs at that stage. Adenosine Diphosphate 36-39 programmed cell death 1 Macaca mulatta 0-4 31333668-12 2019 PD-1 blockade enhanced SIV-specific ADP by AMs from chronic infection indicating that the PD-1/PD-L2 pathway may modulate functional activity of AMs at that stage. Adenosine Diphosphate 36-39 programmed cell death 1 Macaca mulatta 90-94 27172914-6 2016 ADP inhibited currents through Cav2.2 channels via both P2Y1 and P2Y12 receptors with phospholipase C and pertussis toxin-sensitive G proteins being involved, respectively. Adenosine Diphosphate 0-3 calcium voltage-gated channel subunit alpha1 B Homo sapiens 31-37 27172914-6 2016 ADP inhibited currents through Cav2.2 channels via both P2Y1 and P2Y12 receptors with phospholipase C and pertussis toxin-sensitive G proteins being involved, respectively. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 65-70 30821416-2 2019 Ecto-F1 -ATPase is a receptor for APOA1, and its activity in endothelial cells is coupled to adenosine diphosphate (ADP)-sensitive P2Y receptors (P2Y ADP receptors). Adenosine Diphosphate 93-114 tripartite motif-containing 33 Mus musculus 0-4 27267671-1 2016 The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into "up" and "down" conformations. Adenosine Diphosphate 90-93 valosin containing protein Homo sapiens 16-19 27267671-1 2016 The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into "up" and "down" conformations. Adenosine Diphosphate 90-93 valosin containing protein Homo sapiens 20-23 27267671-6 2016 Notably, p47 and p37 bind 8-fold more weakly to the ADP-bound conformation of wild-type p97 compared to the ATP-bound conformation. Adenosine Diphosphate 52-55 nucleoporin 37 Homo sapiens 17-20 27267671-6 2016 Notably, p47 and p37 bind 8-fold more weakly to the ADP-bound conformation of wild-type p97 compared to the ATP-bound conformation. Adenosine Diphosphate 52-55 valosin containing protein Homo sapiens 88-91 27090373-3 2016 Recently, the first high-resolution structures of the NSF (in both ATP and ADP state) and 20S (in four distinct states termed I, II, IIIa, and IIIb) were solved by cryo-electron microscopy (cryo-EM), which have paved the way for structure-driven studies of the SNARE recycling mechanism. Adenosine Diphosphate 75-78 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 54-57 27090373-8 2016 Finally, the conformational changes in 20S as induced by the transition of NSF from ATP to ADP state were modeled, and a concerted untwisting motion of SNARE/SNAPs and a sideway flip of two amino-terminal domains were observed. Adenosine Diphosphate 91-94 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 75-78 27419376-5 2016 In line with this uptake of C3bot into Vim-/- neurons was strongly decreased resulting in reduced ADP-ribosylation of RhoA and B as detected by an antibody recognizing selectively ADP-ribosylated RhoA/B. Adenosine Diphosphate 98-101 ras homolog family member A Mus musculus 118-122 27419376-5 2016 In line with this uptake of C3bot into Vim-/- neurons was strongly decreased resulting in reduced ADP-ribosylation of RhoA and B as detected by an antibody recognizing selectively ADP-ribosylated RhoA/B. Adenosine Diphosphate 180-183 ras homolog family member A Mus musculus 196-202 27419376-11 2016 In line with this uptake of C3bot into vimentin KO neurons was strongly decreased resulting in reduced ADP-ribosylation of RhoA and B as detected by an antibody recognizing selectively ADP-ribosylated RhoA/B. Adenosine Diphosphate 103-106 ras homolog family member A Mus musculus 123-127 30821416-2 2019 Ecto-F1 -ATPase is a receptor for APOA1, and its activity in endothelial cells is coupled to adenosine diphosphate (ADP)-sensitive P2Y receptors (P2Y ADP receptors). Adenosine Diphosphate 116-119 tripartite motif-containing 33 Mus musculus 0-4 27620165-6 2016 RESULTS: Surprisingly, we found that activation of Rap1b in response to thrombin, ADP, or U46619 was significantly reduced in platelets from VASP-null mice compared to platelets from wild type mice. Adenosine Diphosphate 82-85 vasodilator-stimulated phosphoprotein Mus musculus 141-145 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 8-11 mono-ADP ribosylhydrolase 1 Homo sapiens 93-100 26562035-6 2016 RESULTS: Consensus guidelines suggest that a platelet aggregation response in response to the agonist ADP of <57% is an adequate therapeutic response to P2Y12 inhibition. Adenosine Diphosphate 102-105 purinergic receptor P2Y12 Homo sapiens 156-161 31075617-2 2019 Here, we evaluated the capacity of CD133+BMSC to utilize platelets for homing to vasculature and concomitant controlling their aggregability upon ADP stimulation. Adenosine Diphosphate 146-149 prominin 1 Homo sapiens 35-40 26837379-7 2016 Relative ADP induced aggregation (r-ADP-agg) was defined as the ADP-TRAP-ratio to reflect an individual degree of P2Y12-dependent platelet inhibition. Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 114-119 27462133-1 2016 EFA6 (exchange factor for ARF6) activates Arf6 (ADP ribosylation factor 6) by exchanging ADP to ATP, and the resulting activated form of Arf6 is involved in the membrane dynamics and actin re-organization of cells. Adenosine Diphosphate 48-51 pleckstrin and Sec7 domain containing Mus musculus 0-4 27462133-1 2016 EFA6 (exchange factor for ARF6) activates Arf6 (ADP ribosylation factor 6) by exchanging ADP to ATP, and the resulting activated form of Arf6 is involved in the membrane dynamics and actin re-organization of cells. Adenosine Diphosphate 48-51 pleckstrin and Sec7 domain containing Mus musculus 6-30 27112599-5 2016 Reconstructions of the apo, ATP, and ADP states identify that Rvb1/2 undergoes substantial conformational changes that include a twist in the insertion-domain position and a corresponding rotation of the AAA+ ring. Adenosine Diphosphate 37-40 RuvB family ATP-dependent DNA helicase pontin Saccharomyces cerevisiae S288C 62-68 26988592-3 2016 Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), the other by P2Y12, a platelet receptor for adenosine diphosphate and the target of antiplatelet drugs. Adenosine Diphosphate 252-273 RAS-related protein 1a Mus musculus 126-130 26988592-3 2016 Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), the other by P2Y12, a platelet receptor for adenosine diphosphate and the target of antiplatelet drugs. Adenosine Diphosphate 252-273 RAS, guanyl releasing protein 2 Mus musculus 188-199 26988592-3 2016 Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), the other by P2Y12, a platelet receptor for adenosine diphosphate and the target of antiplatelet drugs. Adenosine Diphosphate 252-273 RAS, guanyl releasing protein 2 Mus musculus 201-205 27105284-6 2016 This mutation does not affect NMS-873 binding but increases p97 catalytic efficiency through altered ATP and ADP binding. Adenosine Diphosphate 109-112 valosin containing protein Homo sapiens 60-63 26862665-7 2016 The ADP dissociation rate of cTnI-ND myofibrils was positively dependent on calcium concentration, while the wild-type controls were not significantly affected. Adenosine Diphosphate 4-7 troponin I, cardiac 3 Mus musculus 29-33 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 mono-ADP ribosylhydrolase 1 Homo sapiens 93-100 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 mono-ADP ribosylhydrolase 1 Homo sapiens 93-100 27155231-3 2016 Multiple turnover kinetics show that Sml1 inhibition of dGTP/ADP- and ATP/CDP-bound ScRR follows a mixed inhibition mechanism. Adenosine Diphosphate 61-64 ribonucleotide reductase inhibiting protein SML1 Saccharomyces cerevisiae S288C 37-41 27089381-6 2016 Mechanistically, TIPARP interacted with the kinase TBK1 and suppressed its activity by ADP-ribosylation. Adenosine Diphosphate 87-90 TCDD-inducible poly(ADP-ribose) polymerase Mus musculus 17-23 27089381-6 2016 Mechanistically, TIPARP interacted with the kinase TBK1 and suppressed its activity by ADP-ribosylation. Adenosine Diphosphate 87-90 TANK-binding kinase 1 Mus musculus 51-55 27223323-0 2016 Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation. Adenosine Diphosphate 0-21 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 71-77 27223323-4 2016 Considering that Hsp104 is characterized by low affinity towards ATP and is strongly inhibited by adenosine diphosphate (ADP), we asked how Hsp104 functions at the physiological levels of adenine nucleotides. Adenosine Diphosphate 98-119 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 17-23 27223323-4 2016 Considering that Hsp104 is characterized by low affinity towards ATP and is strongly inhibited by adenosine diphosphate (ADP), we asked how Hsp104 functions at the physiological levels of adenine nucleotides. Adenosine Diphosphate 121-124 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 17-23 27223323-5 2016 We demonstrate that physiological levels of ADP highly limit Hsp104 activity. Adenosine Diphosphate 44-47 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 61-67 26608812-3 2016 Although the atomic structure of Hsp104 hexamers remains uncertain, volumetric reconstruction of Hsp104 hexamers in ATPgammaS, ADP-AlFx (ATP hydrolysis transition-state mimic), and ADP via small-angle x-ray scattering has revealed a peristaltic pumping motion upon ATP hydrolysis. Adenosine Diphosphate 127-130 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 97-103 26519900-4 2016 One important example is the ADP-induced platelet aggregation mediated by P2Y1 and P2Y12 receptors. Adenosine Diphosphate 29-32 purinergic receptor P2Y12 Homo sapiens 83-88 27063142-1 2016 Mammalian AMP-activated protein kinase (AMPK) acts as an important sensor of cellular energy homeostasis related with AMP/ADP to ATP ratio. Adenosine Diphosphate 122-125 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 10-38 27063142-1 2016 Mammalian AMP-activated protein kinase (AMPK) acts as an important sensor of cellular energy homeostasis related with AMP/ADP to ATP ratio. Adenosine Diphosphate 122-125 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 27030757-8 2016 Adenosine kinase acts as a highly sensitive and important metabolic sensor of the glial ATP/ADP and AMP ratio directly controlling intracellular adenosine concentration. Adenosine Diphosphate 92-95 adenosine kinase Mus musculus 0-16 26620526-2 2016 PPDK regulatory protein (PDRP) regulates the inorganic phosphate-dependent activation and ADP-dependent inactivation of PPDK by reversible phosphorylation. Adenosine Diphosphate 90-93 pyruvate, phosphate dikinase 1, chloroplastic Zea mays 0-4 26754066-9 2016 More importantly, in vitro pre-treatment with CTRP9 significantly inhibited ADP-stimulated platelet activation in platelet samples from both ND and HFD animals. Adenosine Diphosphate 76-79 C1q and TNF related 9 Homo sapiens 46-51 26328528-7 2016 Two unique components are genetically combined in this molecule: 1) The ecto-nucleoside triphosphate diphosphohydrolase NTPDase CD39, which enzymatically degrades ATP and ADP to AMP, which is then further degraded to adenosine by the endothelially expressed CD73. Adenosine Diphosphate 171-174 5'-nucleotidase ecto Homo sapiens 258-262 27028818-8 2016 According to the data obtained by Western blot, upon the cell activation with ADP, the number of GP IIb-IIIa and P2Y12 receptors increases, which may serve as evidence of these proteins being synthesized in the activated platelets. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 113-118 25970449-6 2016 Notably, lysosomal exocytosis in response to thrombin was significantly reduced if the secondary activation by ADP was inhibited by the P2Y12 antagonist cangrelor, while inhibition of thromboxane A2 formation by treatment with acetylsalicylic acid was of minor importance in this regard. Adenosine Diphosphate 111-114 purinergic receptor P2Y12 Homo sapiens 136-141 25970449-9 2016 Furthermore, we suggest that secondary release of ADP and concomitant signaling via PAR1/4- and P2Y12 receptors is important for efficient platelet lysosomal exocytosis by thrombin. Adenosine Diphosphate 50-53 purinergic receptor P2Y12 Homo sapiens 96-101 26546721-8 2015 In contrast to current antiplatelet strategies, the glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist RGDS peptide only prevented cancer cells-induced platelet aggregation, but not platelet adhesion and secretion; whereas the cyclooxygenase inhibitor aspirin and the adenosine diphosphate (ADP) scavenger apyrase affected neither platelet aggregation nor platelet secretion. Adenosine Diphosphate 263-284 ral guanine nucleotide dissociation stimulator Homo sapiens 98-102 26546721-8 2015 In contrast to current antiplatelet strategies, the glycoprotein IIb/IIIa (GPIIb/IIIa) antagonist RGDS peptide only prevented cancer cells-induced platelet aggregation, but not platelet adhesion and secretion; whereas the cyclooxygenase inhibitor aspirin and the adenosine diphosphate (ADP) scavenger apyrase affected neither platelet aggregation nor platelet secretion. Adenosine Diphosphate 286-289 ral guanine nucleotide dissociation stimulator Homo sapiens 98-102 26260792-5 2015 Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP, and AMP with kcat values of 1.9, 0.6, and 0.32 min(-1), respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Adenosine Diphosphate 56-59 carboxylesterase 1 Homo sapiens 34-39 26260792-5 2015 Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP, and AMP with kcat values of 1.9, 0.6, and 0.32 min(-1), respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Adenosine Diphosphate 56-59 carboxylesterase 1 Homo sapiens 147-152 26260792-5 2015 Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP, and AMP with kcat values of 1.9, 0.6, and 0.32 min(-1), respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Adenosine Diphosphate 161-164 carboxylesterase 1 Homo sapiens 34-39 26260792-5 2015 Biochemical assays confirmed that A-CAT hydrolyzed ATP, ADP, and AMP with kcat values of 1.9, 0.6, and 0.32 min(-1), respectively, and showed that A-CAT can use ADP to phosphorylate peptides and proteins. Adenosine Diphosphate 161-164 carboxylesterase 1 Homo sapiens 147-152 26260792-6 2015 Binding assays using fluorescent 2"/3"-O-(N-methylanthraniloyl) analogs of ATP and ADP yielded Kd values for ATP, ADP, AMP, and adenosine of 20 +- 3, 60 +- 20, 160 +- 60, and 45 +- 15 muM, respectively. Adenosine Diphosphate 83-86 ATPase phospholipid transporting 8A2 Homo sapiens 109-187 26150473-6 2015 AK2-deficient iPSCs recapitulated the characteristic myeloid maturation arrest at the promyelocyte stage and demonstrated an increased AMP/ADP ratio, indicative of an energy-depleted adenine nucleotide profile. Adenosine Diphosphate 139-142 adenylate kinase 2 Homo sapiens 0-3 25887396-1 2015 The ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) and two other non-membrane-bound ABC proteins, Rad50 and a structural maintenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of physiologic concentrations of ATP and AMP or ADP (ATP + AMP 2 ADP). Adenosine Diphosphate 311-314 RAD50 double strand break repair protein Homo sapiens 149-154 25887396-1 2015 The ATP-binding cassette (ABC) transporter cystic fibrosis transmembrane conductance regulator (CFTR) and two other non-membrane-bound ABC proteins, Rad50 and a structural maintenance of chromosome (SMC) protein, exhibit adenylate kinase activity in the presence of physiologic concentrations of ATP and AMP or ADP (ATP + AMP 2 ADP). Adenosine Diphosphate 330-333 RAD50 double strand break repair protein Homo sapiens 149-154 25976494-2 2015 Oral antiplatelet agents for secondary prevention include the cyclo-oxygenase-1 inhibitor aspirin, and the ADP dependent P2Y12 inhibitors clopidogrel, prasugrel and ticagrelor. Adenosine Diphosphate 107-110 purinergic receptor P2Y12 Homo sapiens 121-126 25705885-7 2015 Moreover, activation of Rasa3 mutant platelets occurred independently of ADP feedback signaling and was insensitive to inhibitors of P2Y12 or PI3 kinase. Adenosine Diphosphate 73-76 RAS p21 protein activator 3 Mus musculus 24-29 25394251-6 2015 However, the incubation of whole blood with CDP-choline prolonged the initial and maximum clot formation time, and CDP-choline treatment significantly decreased the slopes of the disaggregation and aggregation curves when platelets were stimulated with ADP and collagen, respectively. Adenosine Diphosphate 253-256 cut-like homeobox 1 Rattus norvegicus 44-47 25394251-6 2015 However, the incubation of whole blood with CDP-choline prolonged the initial and maximum clot formation time, and CDP-choline treatment significantly decreased the slopes of the disaggregation and aggregation curves when platelets were stimulated with ADP and collagen, respectively. Adenosine Diphosphate 253-256 cut-like homeobox 1 Rattus norvegicus 115-118 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 75-78 serine/threonine protein kinase BUD32 Saccharomyces cerevisiae S288C 46-51 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 75-78 serine/threonine protein kinase BUD32 Saccharomyces cerevisiae S288C 131-136 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 93-96 serine/threonine protein kinase BUD32 Saccharomyces cerevisiae S288C 46-51 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 93-96 serine/threonine protein kinase BUD32 Saccharomyces cerevisiae S288C 131-136 25556665-8 2015 Adenosine monophosphate (AMP) and adenosine diphosphate (ADP) accumulation activates AMP protein kinase (AMPK) and increases entry of glucose into glycolysis. Adenosine Diphosphate 34-55 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 25556665-8 2015 Adenosine monophosphate (AMP) and adenosine diphosphate (ADP) accumulation activates AMP protein kinase (AMPK) and increases entry of glucose into glycolysis. Adenosine Diphosphate 57-60 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 105-109 26876938-2 2016 When intracellular ATP levels decrease during energy stress, AMPK is initially activated through AMP or ADP binding and phosphorylation of a threonine residue (Thr-172) within the activation loop of its kinase domain. Adenosine Diphosphate 104-107 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 61-65 26885820-0 2016 The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y12-Dependent Platelet Inhibition Independently of the Platelet Count. Adenosine Diphosphate 13-16 purinergic receptor P2Y12 Homo sapiens 66-71 26885820-1 2016 OBJECTIVE: This study aimed to assess the association of clinical factors with P2Y12-dependent platelet inhibition as monitored by the ratio of ADP- to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively. Adenosine Diphosphate 144-147 purinergic receptor P2Y12 Homo sapiens 79-84 26885820-1 2016 OBJECTIVE: This study aimed to assess the association of clinical factors with P2Y12-dependent platelet inhibition as monitored by the ratio of ADP- to TRAP-induced platelet aggregation and conventional ADP-induced aggregation, respectively. Adenosine Diphosphate 203-206 purinergic receptor P2Y12 Homo sapiens 79-84 26885820-5 2016 Relative ADP-induced aggregation (r-ADP-agg) was defined as the ratio of ADP- to TRAP- induced aggregation reflecting the individual degree of P2Y12-mediated platelet reactivity. Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 143-148 26885820-11 2016 CONCLUSION: The ratio of ADP- to TRAP-induced platelet aggregation quantifies P2Y12-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation. Adenosine Diphosphate 25-28 purinergic receptor P2Y12 Homo sapiens 78-83 26885820-13 2016 Thus, the r-ADP-agg is a more valid reflecting platelet aggregation and potentially prognosis after coronary stent-implantation in P2Y12-mediated HPR than conventional ADP-induced platelet aggregation. Adenosine Diphosphate 12-15 purinergic receptor P2Y12 Homo sapiens 131-136 26409464-1 2016 SUCLA2 encodes for a subunit of succinyl-coenzyme A synthase, the enzyme that reversibly synthesises succinyl-coenzyme A and ATP from succinate, coenzyme A and ADP in the Krebs cycle. Adenosine Diphosphate 160-163 succinate-CoA ligase ADP-forming subunit beta Homo sapiens 0-6 26682803-3 2015 KATP channels are inhibited by ATP (or ADP) binding to Kir6.2 and activated by Mg-nucleotide interactions with SUR. Adenosine Diphosphate 39-42 ATP binding cassette subfamily C member 8 Homo sapiens 111-114 25745182-1 2015 In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5"-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of alpha-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation. Adenosine Diphosphate 116-140 prolyl 4-hydroxylase subunit beta Homo sapiens 275-302 25745182-1 2015 In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5"-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of alpha-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation. Adenosine Diphosphate 116-140 prolyl 4-hydroxylase subunit beta Homo sapiens 304-307 31075617-7 2019 However, CD133+BMSC inhibited ADP-mediated platelet activation and aggregation. Adenosine Diphosphate 30-33 prominin 1 Homo sapiens 9-14 25745182-1 2015 In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5"-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of alpha-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation. Adenosine Diphosphate 142-145 prolyl 4-hydroxylase subunit beta Homo sapiens 275-302 25745182-1 2015 In this issue of Blood, Meng et al and Sharda et al use the Hermansky-Pudlak syndrome (HPS) as a model to show that adenosine 5"-diphosphate (ADP) released by dense granules serves as an autocrine signal to potentiate platelet release of alpha-granule and lysosome cargo and protein disulfide isomerase (PDI), all of which serve to stabilize thrombus formation. Adenosine Diphosphate 142-145 prolyl 4-hydroxylase subunit beta Homo sapiens 304-307 31075617-11 2019 CONCLUSION: We provide evidence that CD133+BMSC are capable of controlling ADP-dependent platelet aggregation and activation by direct interaction dependent on cellular expression of ectoNTPDase-1. Adenosine Diphosphate 75-78 prominin 1 Homo sapiens 37-42 26549451-5 2015 Lamin A promotes SIRT6-dependent DNA-PKcs (DNA-PK catalytic subunit) recruitment to chromatin, CtIP deacetylation, and PARP1 mono-ADP ribosylation in response to DNA damage. Adenosine Diphosphate 130-133 sirtuin 6 Homo sapiens 17-22 31016551-4 2019 These cells co-express P2X7 and ADP-ribosyltransferase ARTC2, permitting gating of P2X7 by NAD+-dependent ADP-ribosylation without the need to add exogenous ATP. Adenosine Diphosphate 32-35 ADP-ribosyltransferase 2a Mus musculus 55-60 25561410-7 2015 In contrast, both MIF and CXCL12 attenuated ADP-induced calcium transients in platelets. Adenosine Diphosphate 44-47 chemokine (C-X-C motif) ligand 12 Mus musculus 26-32 31034271-9 2019 Phosphorylation of VASP in response to ADP (20muM) and prostaglandin E1 (3.3muM) was also unchanged by administration of clopidogrel. Adenosine Diphosphate 39-42 vasodilator stimulated phosphoprotein Equus caballus 19-23 25403716-1 2015 The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. Adenosine Diphosphate 93-114 5'-nucleotidase ecto Homo sapiens 31-35 25403716-1 2015 The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. Adenosine Diphosphate 116-119 5'-nucleotidase ecto Homo sapiens 31-35 25750704-2 2015 Cerebellar astrocytes and granule neurons provide excellent models to study P2Y13 expression and function since the first identification of ADP-evoked calcium responses not attributable to the related P2Y1 receptor was performed in these cell populations. Adenosine Diphosphate 140-143 purinergic receptor P2Y13 Homo sapiens 76-81 25750704-3 2015 In this regard, all responses induced by ADP analogues in astrocytes resulted to be Gi-coupled activities mediated by P2Y13 instead of P2Y1 receptors. Adenosine Diphosphate 41-44 purinergic receptor P2Y13 Homo sapiens 118-123 26381437-7 2015 RESULTS: CK2 inhibition by CX-4945 suppressed adenosin diphosphate (ADP)- and proteinase-activated receptor-1-peptide (PAR-1-AP)-stimulated platelet aggregation, which was associated with down-regulation of P-selectin, GPIIb/IIIa and a reduced formation of PLA. Adenosine Diphosphate 68-71 casein kinase 2, alpha prime polypeptide Mus musculus 9-12 26448282-4 2015 We found that adenosine 5"-diphosphate (ADP) induced human eosinophils to secrete eosinophil peroxidase (EPO) in a P2Y12R dependent manner. Adenosine Diphosphate 14-38 purinergic receptor P2Y12 Homo sapiens 115-121 26448282-4 2015 We found that adenosine 5"-diphosphate (ADP) induced human eosinophils to secrete eosinophil peroxidase (EPO) in a P2Y12R dependent manner. Adenosine Diphosphate 40-43 purinergic receptor P2Y12 Homo sapiens 115-121 26297398-6 2015 RESULTS: In control blood samples, P2Y12, TPalpha or PAR1 antagonists markedly reduced ADP-test, ASPI-test and TRAP-test results respectively. Adenosine Diphosphate 87-90 purinergic receptor P2Y12 Homo sapiens 35-40 26324887-4 2015 The preferential mitochondrial localization of HK2 at voltage-dependent anion channels provides access to ATP generated by oxidative phosphorylation and generates an ADP/ATP recycling mechanism to maintain high respiration rates and low electron leak. Adenosine Diphosphate 166-169 hexokinase 2 Homo sapiens 47-50 30698745-6 2019 Molecular dynamics simulations show that the wild type MR subcomplex bound to ATP lingers in a tightly "closed" conformation, while ADP presence leads to the destabilization of Rad50 dimer and of Mre11-Rad50 association, both events being required for MR conformational transition to an open state. Adenosine Diphosphate 132-135 RAD50 double strand break repair protein Homo sapiens 177-182 26216646-3 2015 When compared to wild-type (WT) plants, air-grown ggt1 plants exhibited glyoxylate accumulation, global changes in amino acid amounts including a decrease in serine content, lower organic acid levels, and modified ATP/ADP and NADP(+) /NADPH ratios. Adenosine Diphosphate 218-221 glutamate:glyoxylate aminotransferase Arabidopsis thaliana 50-54 26216646-7 2015 RuBisCO content, activity and activation state were not altered after a short-term transfer while the ATP/ADP ratio was lowered in ggt1 rosettes. Adenosine Diphosphate 106-109 glutamate:glyoxylate aminotransferase Arabidopsis thaliana 131-135 30698745-6 2019 Molecular dynamics simulations show that the wild type MR subcomplex bound to ATP lingers in a tightly "closed" conformation, while ADP presence leads to the destabilization of Rad50 dimer and of Mre11-Rad50 association, both events being required for MR conformational transition to an open state. Adenosine Diphosphate 132-135 RAD50 double strand break repair protein Homo sapiens 202-207 30700550-6 2019 Moreover, time-resolved measurements revealed that in ob/ob islets, where complex I flux dominates respiration, CDK1 inhibition is sufficient to restrict the duty cycle of ATP/ADP and calcium oscillations, the parameter that dynamically encodes beta-cell glucose sensing. Adenosine Diphosphate 176-179 cyclin-dependent kinase 1 Mus musculus 112-116 30475578-10 2019 GFA relieved mechanical and thermal hyperalgesia in the CCI rats, decreased the expression of P2Y12 mRNA and protein and phosphorylation of p38 MAPK in the DRG, and increased the ADP-downregulated cAMP concentrations in HEK293 cells transfected with P2Y12 plasmid. Adenosine Diphosphate 179-182 purinergic receptor P2Y12 Homo sapiens 250-255 25837834-2 2015 The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2 and P2Y4), UDP (P2Y6 and P2Y14), and UDP glucose (P2Y14). Adenosine Diphosphate 61-64 purinergic receptor P2Y12 Homo sapiens 72-77 25837834-2 2015 The human P2YRs are fully activated by ATP (P2Y2 and P2Y11), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2 and P2Y4), UDP (P2Y6 and P2Y14), and UDP glucose (P2Y14). Adenosine Diphosphate 61-64 purinergic receptor P2Y13 Homo sapiens 83-88 30916503-8 2019 Preterm cord blood platelets showed decreased ADP-induced activation in both activation markers: PAC1 and p-selectin, but only p-selectin reached statistical significance. Adenosine Diphosphate 46-49 dual specificity phosphatase 2 Homo sapiens 97-101 26045476-4 2015 After 5 min of reperfusion (n = 4/group), prominent phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) was observed, both in control and reperfused myocardium, in animals receiving GIK, and mitochondria from these hearts showed reduced ADP-stimulated respiration. Adenosine Diphosphate 253-256 nitric oxide synthase 3 Sus scrofa 79-112 25882759-1 2015 INTRODUCTION: ADP-induced platelet activation via P2Y12 receptor plays a pivotal role in the pathophysiology of arterial thrombosis and acute coronary syndrome. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 50-55 30600215-1 2019 BACKGROUND: The P2Y13 purinergic receptor regulates hepatic high-density lipoprotein uptake and biliary sterol secretion; it acts downstream of the membrane ecto-F1-adenosine triphosphatase, which generates extracellular adenosine diphosphate that selectively activates P2Y13, resulting in high-density lipoprotein endocytosis. Adenosine Diphosphate 221-242 purinergic receptor P2Y13 Homo sapiens 16-21 26149010-3 2015 Defects of P2Y12R should be suspected when ADP, even at high concentrations (>= 10 mum), is unable to induce full, irreversible platelet aggregation. Adenosine Diphosphate 43-46 purinergic receptor P2Y12 Homo sapiens 11-17 30600215-1 2019 BACKGROUND: The P2Y13 purinergic receptor regulates hepatic high-density lipoprotein uptake and biliary sterol secretion; it acts downstream of the membrane ecto-F1-adenosine triphosphatase, which generates extracellular adenosine diphosphate that selectively activates P2Y13, resulting in high-density lipoprotein endocytosis. Adenosine Diphosphate 221-242 purinergic receptor P2Y13 Homo sapiens 270-275 30691122-1 2019 Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). Adenosine Diphosphate 29-32 poly (ADP-ribose) polymerase family, member 2 Mus musculus 170-176 25833713-4 2015 Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. Adenosine Diphosphate 98-101 Ant1p Saccharomyces cerevisiae S288C 0-32 25833713-4 2015 Adenine nucleotide translocase 1 (Ant1) is a mitochondrial inner membrane protein involved in ATP/ADP exchange. Adenosine Diphosphate 98-101 Ant1p Saccharomyces cerevisiae S288C 34-38 31776981-2 2019 Under various physiological and pathological conditions, AMPK can be phosphorylated by an upstream kinase and bind to AMP or ADP rather than ATP, leading to its activation. Adenosine Diphosphate 125-128 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 57-61 25641006-5 2015 RESULTS: Our results demonstrate that clopidogrel had no and prasugrel had only mild effects on donor PLT function, but the reversible P2Y12 inhibitor ticagrelor completely abolished adenosine diphosphate-mediated PLT activation in all assays tested. Adenosine Diphosphate 183-204 purinergic receptor P2Y12 Homo sapiens 135-140 30302530-5 2019 Moreover, animal studies have also shown that the P2Y12 receptor may participate in atherogenesis by promoting the proliferation and migration of vascular smooth muscle cells (VSMCs) and endothelial dysfunction, and affecting inflammatory cell activities in addition to amplifying and maintaining ADP-induced platelet activation and platelet aggregation. Adenosine Diphosphate 297-300 purinergic receptor P2Y12 Homo sapiens 50-55 26042119-4 2015 Murine T cells express a sensitive splice variant of P2X7 that can be activated either by non-covalent binding of ATP or, in the presence of nicotinamide adenine dinucleotide, by its covalent ADP-ribosylation catalyzed by the ecto-ADP-ribosyltransferase ARTC2.2. Adenosine Diphosphate 192-195 ADP-ribosyltransferase 2a Mus musculus 254-259 25594796-6 2015 ADP-specific assays (VASP PRI) differed according to CYP2C19 genotype, with a significant gene-dose effect (PMs > IMs > EMs, p < 0.05). Adenosine Diphosphate 0-3 vasodilator stimulated phosphoprotein Homo sapiens 21-25 30204045-10 2019 We found significant correlations among all flow cytometric assays measuring platelet CD62P and PAC1 expression induced by ADP or TRAP. Adenosine Diphosphate 123-126 dual specificity phosphatase 2 Homo sapiens 96-100 25645301-11 2015 We suggest that the prothrombotic nature of smoking could be a cause of elevated ADP, and this may explain why cardiovascular patients who smoke benefit from platelet P2Y12 receptor antagonists more than their nonsmoking peers. Adenosine Diphosphate 81-84 purinergic receptor P2Y12 Homo sapiens 167-172 30204045-14 2019 Spontaneous CD62P and PAC1 expression were significantly greater, and ADP-induced aggregation and agonist-induced increase in CD62P and PAC1 were significantly lower in PPCA compared to APC and PPC on day 4 of storage. Adenosine Diphosphate 70-73 dual specificity phosphatase 2 Homo sapiens 136-140 25605724-4 2015 However, IF1-silenced cells displayed an enhanced steady-state mitochondrial membrane potential and consistently showed a reduced ADP-stimulated respiration rate. Adenosine Diphosphate 130-133 ATP synthase inhibitory factor subunit 1 Homo sapiens 9-12 30204045-15 2019 ADP and TRAP-induced CD62P and PAC1 activatability fell significantly during storage between day 1 and day 4 in APC and PPCA, but not in PPC. Adenosine Diphosphate 0-3 dual specificity phosphatase 2 Homo sapiens 31-35 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 75-96 nudix hydrolase 9 Homo sapiens 20-25 25553891-3 2015 Galactokinase (GALK) is an upstream enzyme of GALT in the Leloir pathway and is responsible for conversion of galactose and ATP to gal-1-p and ADP. Adenosine Diphosphate 143-146 galactokinase 1 Homo sapiens 0-13 25553891-3 2015 Galactokinase (GALK) is an upstream enzyme of GALT in the Leloir pathway and is responsible for conversion of galactose and ATP to gal-1-p and ADP. Adenosine Diphosphate 143-146 galactokinase 1 Homo sapiens 15-19 25658937-6 2015 The findings of this study indicate that EMILIN2 influences platelet aggregation induced by adenosine diphosphate, collagen, and thrombin with both EMILIN2-deficient platelets and EMILIN2-deficient plasma contributing to the impaired aggregation response. Adenosine Diphosphate 92-113 elastin microfibril interfacer 2 Mus musculus 41-48 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 98-101 nudix hydrolase 9 Homo sapiens 20-25 30232152-3 2018 AMPK responds to the cellular ATP/AMP and ATP/ADP ratios by matching mitochondrial ATP production to demand. Adenosine Diphosphate 46-49 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 25428217-1 2015 Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. Adenosine Diphosphate 52-73 purinergic receptor P2Y12 Homo sapiens 24-38 25428217-1 2015 Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. Adenosine Diphosphate 52-73 purinergic receptor P2Y12 Homo sapiens 40-46 25428217-1 2015 Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. Adenosine Diphosphate 75-78 purinergic receptor P2Y12 Homo sapiens 24-38 25428217-1 2015 Defects of the platelet P2Y12 receptor (P2Y12R) for adenosine diphosphate (ADP) are associated with increased bleeding risk. Adenosine Diphosphate 75-78 purinergic receptor P2Y12 Homo sapiens 40-46 25428217-10 2015 These studies delineate a region of P2Y12R required for normal function after ADP binding. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 36-42 25122135-3 2015 AMPK exists as alphabetagamma trimeric complexes that are allosterically regulated by AMP, ADP, and ATP. Adenosine Diphosphate 91-94 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 29984433-0 2018 Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells. Adenosine Diphosphate 0-21 matrix metallopeptidase 2 Homo sapiens 32-36 25517796-7 2015 The mutated ATP6V1B1structure superimposed with wild type showed extensive variations with RMSD 1.336 A and could not bind to substrate ADP leading to non-functional ATPase. Adenosine Diphosphate 136-139 ATPase H+ transporting V1 subunit B1 Homo sapiens 12-20 29984433-3 2018 Using real-time PCR, we showed that activation of the P2Y1 receptor by ADP increased the expression of MMP2/9 mRNAs; MMP2/9 collected from conditioned media also showed an increase in activity; and ADP induced the nuclear localization of MMP2/9. Adenosine Diphosphate 71-74 matrix metallopeptidase 2 Homo sapiens 103-109 29984433-3 2018 Using real-time PCR, we showed that activation of the P2Y1 receptor by ADP increased the expression of MMP2/9 mRNAs; MMP2/9 collected from conditioned media also showed an increase in activity; and ADP induced the nuclear localization of MMP2/9. Adenosine Diphosphate 198-201 matrix metallopeptidase 2 Homo sapiens 103-109 24878761-4 2015 Moreover, the macrodomain-containing proteins MacroD1, MacroD2, and TARG1/C6orf130 were recently described as hydrolases, which remove mono-ADP-ribosylation thus providing evidence that this modification is reversible. Adenosine Diphosphate 140-143 mono-ADP ribosylhydrolase 1 Homo sapiens 46-53 29984433-4 2018 The effects of ADP on transcription of the MMPs were due to activation of c-Src, Akt, and NF-kappaB, while ERK1/2 phosphorylation was needed for the increase in enzymatic activity and the regulation of nuclear import. Adenosine Diphosphate 15-18 matrix metallopeptidase 2 Homo sapiens 43-47 29984433-5 2018 We also showed that the nuclear localization of MMP2/9 induced by ADP causes the cleavage and inactivation of poly-ADP-ribose polymerase-1. Adenosine Diphosphate 66-69 matrix metallopeptidase 2 Homo sapiens 48-54 30235277-6 2018 P-selectin expression, a marker of platelet activation, at baseline and in reactivity to stimulation by adenosine diphosphate (ADP), were higher in HbE/ss-thal subjects than normal subjects. Adenosine Diphosphate 104-125 hemoglobin subunit epsilon 1 Homo sapiens 148-151 26483843-6 2015 Unlike ADP injection alone, which caused significant reduction of peripheral platelet count, Pt-A treatment prevented the drop of peripheral platelet counts; interestingly, Pt-B could not, even though the same amount of Pt-B also showed protection effects on ADP-induced paralysis and thrombosis. Adenosine Diphosphate 259-262 pre T cell antigen receptor alpha Homo sapiens 93-97 25553457-3 2015 This modification results in the loss of the membrane fission activity of the C-terminal binding protein (CtBP)1/ BFA-ADP-ribosylated substrate (BARS), thus blocking progression of cells into mitosis, with important implications for the design of new anticancer drugs. Adenosine Diphosphate 118-121 C-terminal binding protein 1 Homo sapiens 106-112 30235277-6 2018 P-selectin expression, a marker of platelet activation, at baseline and in reactivity to stimulation by adenosine diphosphate (ADP), were higher in HbE/ss-thal subjects than normal subjects. Adenosine Diphosphate 127-130 hemoglobin subunit epsilon 1 Homo sapiens 148-151 30235277-8 2018 Nitrite plus deoxygenated erythrocytes from HbE/ss-thal subjects had a lower ability to inhibit ADP-induced P-selectin expression on platelets than erythrocytes from normal subjects. Adenosine Diphosphate 96-99 hemoglobin subunit epsilon 1 Homo sapiens 44-47 25297118-6 2015 P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) gene is coding a receptor, which is situated on the surface of the platelets and plays a role in ADP-induced platelet aggregation. Adenosine Diphosphate 153-156 purinergic receptor P2Y12 Homo sapiens 0-6 25297118-6 2015 P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) gene is coding a receptor, which is situated on the surface of the platelets and plays a role in ADP-induced platelet aggregation. Adenosine Diphosphate 153-156 purinergic receptor P2Y12 Homo sapiens 8-54 30176535-2 2018 We describe new ADP analogues as CD73 inhibitors based on the replacement of the adenosine moiety, in the reference inhibitor APCP, by purine nucleoside analogues. Adenosine Diphosphate 16-19 5'-nucleotidase ecto Homo sapiens 33-37 25115434-5 2014 Significant correlations were found between the area under the time-concentration curve (AUC0- ) of CAMD and both the absolute ADP-induced P2Y12 receptor-activated platelet aggregation (r = -0.60, P = 0.0007) and the percentage inhibition of aggregation (r = 0.59, P = 0.0009). Adenosine Diphosphate 128-131 purinergic receptor P2Y12 Homo sapiens 140-145 25115434-7 2014 Neither the absolute ADP-induced P2Y12 receptor-activated platelet aggregation, exposure to CAMD nor the pharmacokinetic parameters of proguanil, cycloguanil and 4-CPB exhibited any significant differences among the genotype groups. Adenosine Diphosphate 21-24 purinergic receptor P2Y12 Homo sapiens 33-38 25135796-1 2014 BACKGROUND: Data on long term - more than 1-year - prognostic value of global platelet reactivity (G-HPR) - by adenosine diphosphate (ADP) and arachidonic acid (AA) - in patients with STEMI undergoing PCI are limited. Adenosine Diphosphate 111-132 haptoglobin-related protein Homo sapiens 101-104 25135796-1 2014 BACKGROUND: Data on long term - more than 1-year - prognostic value of global platelet reactivity (G-HPR) - by adenosine diphosphate (ADP) and arachidonic acid (AA) - in patients with STEMI undergoing PCI are limited. Adenosine Diphosphate 134-137 haptoglobin-related protein Homo sapiens 101-104 25084564-0 2014 Oxidative stress activates AMPK in cultured cells primarily by increasing cellular AMP and/or ADP. Adenosine Diphosphate 94-97 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 27-31 25075638-3 2014 It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. Adenosine Diphosphate 115-118 purinergic receptor P2Y12 Homo sapiens 49-54 25075638-3 2014 It is a potent, highly selective, and reversible P2Y12 receptor antagonist and by far the most potent inhibitor of ADP-induced platelet aggregation among the P2Y12 antagonists described in the literature. Adenosine Diphosphate 115-118 purinergic receptor P2Y12 Homo sapiens 158-163 25059833-8 2014 The ADP-stimulated release of platelet-derived growth factor (PDGF)-AB and the soluble CD40 (sCD40) ligand was inhibited by EGCG. Adenosine Diphosphate 4-7 CD40 molecule Homo sapiens 87-91 24836986-1 2014 The multidrug resistance protein 4 (MRP4) is a member of the ABCC subfamily of the adenosine triphosphate-binding cassette transporters that remove cyclic nucleotides from platelets and uptake ADP into dense granule in platelets. Adenosine Diphosphate 193-196 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 4-34 24836986-1 2014 The multidrug resistance protein 4 (MRP4) is a member of the ABCC subfamily of the adenosine triphosphate-binding cassette transporters that remove cyclic nucleotides from platelets and uptake ADP into dense granule in platelets. Adenosine Diphosphate 193-196 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 Mus musculus 36-40 25100739-3 2014 To devise a different strategy, we engineered and optimized the apyrase activity of human nucleoside triphosphate diphosphohydrolase-3 (CD39L3) to enhance scavenging of extracellular adenosine diphosphate, a predominant ligand of P2Y12 receptors. Adenosine Diphosphate 183-204 purinergic receptor P2Y12 Homo sapiens 230-235 24709060-0 2014 Extracellular ADP prevents neuronal apoptosis via activation of cell antioxidant enzymes and protection of mitochondrial ANT-1. Adenosine Diphosphate 14-17 solute carrier family 25 member 4 Rattus norvegicus 121-126 24953906-13 2014 This inhibition was not due to direct toxic effects of these agents, nor was inhibition of ADP-induced aggregation TRPV1 mediated. Adenosine Diphosphate 91-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 24600452-2 2014 Nucleotides such as adenosine triphosphate and adenosine diphosphate are release from injured and necrotic cells and hydrolyzed to adenosine monophosphate and adenosine by the concerted action of the ectonucleotidases CD39 and CD73. Adenosine Diphosphate 47-68 5'-nucleotidase ecto Homo sapiens 227-231 24299989-5 2014 Via coupled enzyme reactions involving ADP-hexokinase, glucose-6-phosphate dehydrogenase, and diaphorase, the ADP is utilized for conversion of resazurin to resorufin, which is determined by fluorescence measurement. Adenosine Diphosphate 39-42 dihydrolipoamide dehydrogenase Homo sapiens 94-104 24450630-1 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Adenosine Diphosphate 118-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 24450630-1 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Adenosine Diphosphate 118-121 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 6-34 24331208-0 2014 Usefulness of the INNOVANCE PFA P2Y test cartridge for the detection of patients with congenital defects of the platelet P2Y12 receptor for adenosine diphosphate. Adenosine Diphosphate 140-161 purinergic receptor P2Y12 Homo sapiens 121-126 24211784-8 2014 In contrast, SB415286, a specific GSK-3beta inhibitor, recovered DEX-induced decrease of ADP proliferation. Adenosine Diphosphate 89-92 glycogen synthase kinase 3 beta Rattus norvegicus 34-43 24845219-2 2014 The P2Y12 receptor is a Gi-coupled receptor that not only regulates ADP-induced aggregation but can also dramatically potentiate secretion, when platelets are activated by other stimuli. Adenosine Diphosphate 68-71 purinergic receptor P2Y12 Homo sapiens 4-9 25350775-8 2015 ADP-induced platelet reactivity was decreased in the patients treated with prasugrel or ticagrelor compared with those on clopidogrel (mean +- SD: 139 +- 71 vs. 313 +- 162 arbitrary units [AU]*min, p = 0.006), due to a more potent antiplatelet activity of the novel P2Y12 antagonists. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 266-271 25350775-9 2015 Consequently, six out of seven patients in the lower tertile of the ADP-induced platelet aggregation were treated with the newer P2Y12 blockers, whereas six out of seven patients in the upper tertile were on clopidogrel. Adenosine Diphosphate 68-71 purinergic receptor P2Y12 Homo sapiens 129-134 25350775-10 2015 Plasma miR-223 was elevated with decreasing platelet reactivity (Spearman"s rho = -0.52; p = 0.015 for trend), being significantly higher in the lower tertile of the ADP-induced platelet aggregation (median [range]: 1.06 [0.25-2.31]) vs. the upper tertile (0.20 [0.13-2.30]) (p = 0.04). Adenosine Diphosphate 166-169 microRNA 223 Homo sapiens 7-14 25734213-6 2015 NBP also inhibited PAC-1 binding induced by ADP or thrombin and platelet spreading on immobilized fibrinogen. Adenosine Diphosphate 44-47 dual specificity phosphatase 2 Homo sapiens 19-24 25734957-0 2015 Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography. Adenosine Diphosphate 62-65 purinergic receptor P2Y12 Homo sapiens 44-49 25734957-7 2015 In conclusion, PGE1 potentiates the anti-aggregatory effects of P2Y12 blockade on ADP-mediated platelet aggregation. Adenosine Diphosphate 82-85 purinergic receptor P2Y12 Homo sapiens 64-69 25059924-8 2014 Ion channel purinergic receptor P2X7 and P2X4 gene silencing with small interference RNA (siRNA) and treatment with the P2X inhibitor, A438079 (100 muM), decrease ADP release from hepatic cells, but have no effect on ATP. Adenosine Diphosphate 163-166 purinergic receptor P2X 4 Homo sapiens 41-45 25427105-10 2014 Adjusting for the influence of hematocrit improved the strength of the correlation between the VerifyNow P2Y12 and MEA ADP assay results. Adenosine Diphosphate 119-122 purinergic receptor P2Y12 Homo sapiens 105-110 25186974-6 2014 RESULTS: The natural agonist ADP inhibited forskolin-induced cAMP formation at the wild-type P2Y12 -receptor with a lower potency (EC50 209 nm) than the synthetic agonist 2-methylthio-ADP (EC50 1.0 nm). Adenosine Diphosphate 29-32 purinergic receptor P2Y12 Homo sapiens 93-98 25186974-10 2014 In cells expressing a recombinant C194A(5.43) -mutant P2Y12 -receptor construct, ticagrelor lost antagonistic potency when tested against ADP or 2-methylthio-ADP. Adenosine Diphosphate 138-141 purinergic receptor P2Y12 Homo sapiens 54-59 25186974-11 2014 CONCLUSIONS: The experiments reveal a surmountable and competitive mode of antagonism of ticagrelor at P2Y12 -receptors activated by either the natural agonist ADP or the synthetic agonist 2-methylthio-ADP. Adenosine Diphosphate 160-163 purinergic receptor P2Y12 Homo sapiens 103-108 25210228-7 2014 Disparity between ATP outflow and adenosine deficit in postinflammatory ileitis is ascribed to feed-forward inhibition of ecto-5"-nucleotidase/CD73 by high extracellular ATP and/or ADP. Adenosine Diphosphate 181-184 5' nucleotidase, ecto Rattus norvegicus 122-142 25210228-7 2014 Disparity between ATP outflow and adenosine deficit in postinflammatory ileitis is ascribed to feed-forward inhibition of ecto-5"-nucleotidase/CD73 by high extracellular ATP and/or ADP. Adenosine Diphosphate 181-184 5' nucleotidase, ecto Rattus norvegicus 143-147 24940684-2 2014 Ectonucleoside triphosphate diphosphohydrolase 1 (eNTPD1, CD39) and ecto-5"-nucleotidase (e5NT, CD73) are ectoenzymes that convert adenosine triphosphate to adenosine diphosphate, adenosine monophosphate and finally to adenosine. Adenosine Diphosphate 157-178 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 0-48 24940684-2 2014 Ectonucleoside triphosphate diphosphohydrolase 1 (eNTPD1, CD39) and ecto-5"-nucleotidase (e5NT, CD73) are ectoenzymes that convert adenosine triphosphate to adenosine diphosphate, adenosine monophosphate and finally to adenosine. Adenosine Diphosphate 157-178 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 50-56 24940684-2 2014 Ectonucleoside triphosphate diphosphohydrolase 1 (eNTPD1, CD39) and ecto-5"-nucleotidase (e5NT, CD73) are ectoenzymes that convert adenosine triphosphate to adenosine diphosphate, adenosine monophosphate and finally to adenosine. Adenosine Diphosphate 157-178 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 58-62 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 5'-nucleotidase ecto Homo sapiens 168-188 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 5'-nucleotidase ecto Homo sapiens 190-194 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 5'-nucleotidase ecto Homo sapiens 198-202 24940685-9 2014 A marked increase of adenosine formation from ADP or ATP was observed only in E5NT/ENTPD1-transfected cells (11.7+-0.1 and 5.7+-2.2 muM respectively) but not in any other condition studied. Adenosine Diphosphate 46-49 5'-nucleotidase ecto Homo sapiens 78-82 25290311-0 2014 Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. Adenosine Diphosphate 41-44 nucleolin Homo sapiens 0-9 25290311-2 2014 In this study, we found by serendipity that ADP treatment of human umbilical vein endothelial cells (HUVEC) and human aortic endothelial cells (HAEC) down-regulated the protein level of nucleolin in a dose- and time-dependent manner. Adenosine Diphosphate 44-47 nucleolin Homo sapiens 186-195 25290311-3 2014 ADP treatment did not decrease the transcript level of nucloelin, suggesting that ADP might induce nucleolin protein degradation. Adenosine Diphosphate 0-3 nucleolin Homo sapiens 99-108 25290311-3 2014 ADP treatment did not decrease the transcript level of nucloelin, suggesting that ADP might induce nucleolin protein degradation. Adenosine Diphosphate 82-85 nucleolin Homo sapiens 99-108 30037614-7 2018 AMPK is a master metabolic regulator activated by increases in ROS, Ca2+, and/or an AMP(ADP)/ATP ratio increase, etc. Adenosine Diphosphate 88-91 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 25290311-8 2014 These results suggested that ADP-induced nucleolin down-regulation was not due to the activation of P2Y1, 12, or 13 receptors. Adenosine Diphosphate 29-32 nucleolin Homo sapiens 41-50 25290311-9 2014 We also found that ADP treatment induced cell cycle arrest in S phase, cell apoptosis and cell proliferation inhibition via nucleolin down-regulation. Adenosine Diphosphate 19-22 nucleolin Homo sapiens 124-133 25290311-10 2014 The over-expression of nucleolin by gene transfer partly reversed ADP-induced cell cycle arrest, cell apoptosis and cell proliferation inhibition. Adenosine Diphosphate 66-69 nucleolin Homo sapiens 23-32 24196231-7 2014 RESULTS: Rg1 significantly inhibited platelet aggregation induced by thrombin, ADP, collagen and U46619, e.g., aggregation rate stimulated by 0.1UmL(-1) thrombin was decreased 46% by Rg1. Adenosine Diphosphate 79-82 protein phosphatase 1, regulatory subunit 3A Mus musculus 9-12 30150297-8 2018 This contrasted with ADP and TxA2, both of which evoked considerably greater maximum responses in RGS10-/- platelets with enhanced Gq- and Gi-mediated signaling. Adenosine Diphosphate 21-24 regulator of G-protein signalling 10 Mus musculus 98-103 24167257-1 2013 The complex kinetics of Pi and ADP release by the chaperonin GroEL/GroES is influenced by the presence of unfolded substrate protein (SP). Adenosine Diphosphate 31-34 heat shock protein family E (Hsp10) member 1 Homo sapiens 67-72 25502126-2 2014 BACKGROUND: VN-P2Y12 is a point-of-care device that measures platelet reactivity to adenosine diphosphate. Adenosine Diphosphate 84-105 purinergic receptor P2Y12 Homo sapiens 15-20 25077998-5 2014 We evaluated the effects of salvianolate on platelets in patients with acute coronary syndrome by measuring ADP-induced PAC-1 binding and P-selectin expression on platelets. Adenosine Diphosphate 108-111 dual specificity phosphatase 2 Homo sapiens 120-125 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 14-35 purinergic receptor P2Y12 Homo sapiens 147-152 24984073-7 2014 Ca2+-dependent release of ADP is also the main component of the activation of the small GTPase Rap1b and the fibrinogen receptor integrin alphaIIbbeta3, which leads to increased platelet aggregation and increased thrombus formation in human whole blood. Adenosine Diphosphate 26-29 RAP1B, member of RAS oncogene family Homo sapiens 95-100 25133494-6 2014 Endogenous Smad3 ADP-ribosylation and protein complexes between Smads and PARPs were studied using proximity ligation assays and co-immunoprecipitation assays, which were complemented by in vitro ADP-ribosylation assays using recombinant proteins. Adenosine Diphosphate 17-20 SMAD family member 3 Homo sapiens 11-16 25133494-8 2014 RESULTS: TGFbeta signaling rapidly induces nuclear ADP-ribosylation of Smad3 that coincides with a relative enhancement of nuclear complexes of Smads with PARP-1 and PARP-2. Adenosine Diphosphate 51-54 SMAD family member 3 Homo sapiens 71-76 24488929-3 2014 In this study, we provide evidence that Tat interacts with Eg5, a microtubule-associated motor protein, and allosterically modulates the ATPase activity of Eg5 by affecting ADP release from the enzyme"s active centre. Adenosine Diphosphate 173-176 tyrosine aminotransferase Homo sapiens 40-43 24059522-7 2013 On the other hand, decreasing the ATP/ADP ratio may ultimately result in switching off the allosteric ATP inhibition of CytOx leading to increased ROS (reactive oxygen species), cytochrome c release and apoptosis. Adenosine Diphosphate 38-41 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 120-125 24059522-7 2013 On the other hand, decreasing the ATP/ADP ratio may ultimately result in switching off the allosteric ATP inhibition of CytOx leading to increased ROS (reactive oxygen species), cytochrome c release and apoptosis. Adenosine Diphosphate 38-41 LOC104968582 Bos taurus 178-190 24059522-8 2013 Moreover, we have previously reported that allosteric ATP inhibition of CytOx is responsible for keeping the membrane potential at low healthy values, thus avoiding the production of ROS and this allosteric ATP inhibition is switched on at a high ATP/ADP ratio. Adenosine Diphosphate 251-254 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 72-77 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 37-40 purinergic receptor P2Y12 Homo sapiens 147-152 24753602-5 2014 Steady-state and transient kinetic analysis of the ATPase cycle shows that the ADP release rate (~13 s(-1)) is similar to the maximum ATPase activity (~12-14 s(-1)) and therefore contributes to rate limitation of the enzymatic cycle. Adenosine Diphosphate 79-82 dynein axonemal heavy chain 8 Homo sapiens 51-57 29752405-6 2018 X-ray structures of katanin"s AAA ATPase in monomeric nucleotide-free and pseudo-oligomeric ADP-bound states revealed conformational changes in the AAA subdomains that explained the structural basis for the instability of the katanin heterododecamer. Adenosine Diphosphate 92-95 dynein axonemal heavy chain 8 Homo sapiens 34-40 24753602-5 2014 Steady-state and transient kinetic analysis of the ATPase cycle shows that the ADP release rate (~13 s(-1)) is similar to the maximum ATPase activity (~12-14 s(-1)) and therefore contributes to rate limitation of the enzymatic cycle. Adenosine Diphosphate 79-82 dynein axonemal heavy chain 8 Homo sapiens 134-140 24816114-0 2014 Structure of human Bloom"s syndrome helicase in complex with ADP and duplex DNA. Adenosine Diphosphate 61-64 helicase for meiosis 1 Homo sapiens 36-44 29574692-0 2018 P2Y12 receptor modulation of ADP-evoked intracellular Ca2+ signalling in THP-1 human monocytic cells. Adenosine Diphosphate 29-32 purinergic receptor P2Y12 Homo sapiens 0-5 24816114-5 2014 Here, the crystal structure of the human BLM helicase in complex with ADP and a 3"-overhang DNA duplex is reported. Adenosine Diphosphate 70-73 helicase for meiosis 1 Homo sapiens 45-53 29574692-1 2018 BACKGROUND AND PURPOSE: The Gi -coupled, ADP-activated P2Y12 receptor is well characterized as playing a key role in platelet activation via crosstalk with the P2Y1 receptor in ADP-evoked intracellular Ca2+ responses. Adenosine Diphosphate 41-44 purinergic receptor P2Y12 Homo sapiens 55-60 29574692-2 2018 However, there is limited knowledge on the role of P2Y12 receptors in ADP-evoked Ca2+ responses in other blood cells. Adenosine Diphosphate 70-73 purinergic receptor P2Y12 Homo sapiens 51-56 29574692-3 2018 Here, we investigated the role of P2Y12 receptor activation in the modulation of ADP-evoked Ca2+ responses in human THP-1 monocytic cells. Adenosine Diphosphate 81-84 purinergic receptor P2Y12 Homo sapiens 34-39 24464222-8 2014 Once inside the cell, ISM co-targets with GRP78 to mitochondria where it interacts with ADP/ATP carriers on the inner membrane and blocks ATP transport from mitochondria to cytosol, thereby causing apoptosis. Adenosine Diphosphate 88-91 isthmin 1, angiogenesis inhibitor Mus musculus 22-25 29574692-7 2018 ADP-evoked responses were attenuated either with pertussis toxin treatment, or P2Y12 receptor inhibition with two chemically distinct antagonists (ticagrelor, IC50 5.3 muM; PSB-0739, IC50 5.6 muM). Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 79-84 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 36-39 CREB regulated transcription coactivator 1 Mus musculus 89-95 29574692-8 2018 ADP-evoked responses were suppressed following siRNA-mediated P2Y12 gene knockdown. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 62-67 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 36-39 CREB regulated transcription coactivator 1 Mus musculus 241-247 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 115-118 CREB regulated transcription coactivator 1 Mus musculus 89-95 29809147-4 2018 Using canonical and variant 601 nucleosomes, we find that the Saccharomyces cerevisiae Chd1 remodeler decreased DNA twist at SHL2 in nucleotide-free and ADP-bound states, and increased twist with transition state analogs. Adenosine Diphosphate 153-156 chromatin-remodeling ATPase CHD1 Saccharomyces cerevisiae S288C 87-91 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 115-118 CREB regulated transcription coactivator 1 Mus musculus 241-247 24612393-9 2014 Rescue of mTORC1 activation with exogenous ADP was completely dependent on the Src family kinases but independent of PI3 kinase/Akt. Adenosine Diphosphate 43-46 CREB regulated transcription coactivator 1 Mus musculus 10-16 24612393-11 2014 CONCLUSION: These results demonstrate that thrombin activates the mTORC1 pathway in human platelets through PKC-mediated ADP secretion and subsequent activation of P2Y(12), in a manner largely independent of the canonical PI3 kinase/Akt pathway. Adenosine Diphosphate 121-124 CREB regulated transcription coactivator 1 Mus musculus 66-72 29867553-11 2018 Furthermore, we found that the CaCC underlying the ADP was significantly larger in SCG neurons from males than from females. Adenosine Diphosphate 51-54 chloride channel accessory 3A1 Mus musculus 31-35 24658080-5 2014 Fluorescence correlation spectroscopy and biochemical evaluation suggested that mysterin dynamically changes its oligomeric forms through ATP/ADP binding and hydrolysis cycles. Adenosine Diphosphate 142-145 ring finger protein 213 Homo sapiens 80-88 24550450-4 2014 We found that ADP-dependent phosphorylation of key endothelial signaling proteins--including endothelial nitric oxide synthase, AMP-activated protein kinase, and the actin-binding MARCKS protein--was blocked by preincubation with PEG-catalase, which degrades H2O2. Adenosine Diphosphate 14-17 myristoylated alanine rich protein kinase C substrate Homo sapiens 180-186 24258486-5 2014 We successfully used VASPFix to measure VASP-P in platelets in both platelet-rich plasma and blood in response to compounds that increase (dibutyryl cAMP, adenosine, iloprost, PGE1) and decrease (ADP, PGE1) cAMP, and to determine the effects of certain receptor antagonists on the results obtained. Adenosine Diphosphate 196-199 vasodilator stimulated phosphoprotein Homo sapiens 40-46 24258486-6 2014 The change in VASP-P brought about by adding ADP to PGE1-stimulated platelets is a combination of the effect of ADP at the P2Y12 receptor and of PGE1 at both IP and EP3 receptors. Adenosine Diphosphate 45-48 vasodilator stimulated phosphoprotein Homo sapiens 14-20 24258486-6 2014 The change in VASP-P brought about by adding ADP to PGE1-stimulated platelets is a combination of the effect of ADP at the P2Y12 receptor and of PGE1 at both IP and EP3 receptors. Adenosine Diphosphate 45-48 purinergic receptor P2Y12 Homo sapiens 123-128 24258486-6 2014 The change in VASP-P brought about by adding ADP to PGE1-stimulated platelets is a combination of the effect of ADP at the P2Y12 receptor and of PGE1 at both IP and EP3 receptors. Adenosine Diphosphate 112-115 vasodilator stimulated phosphoprotein Homo sapiens 14-20 24258486-6 2014 The change in VASP-P brought about by adding ADP to PGE1-stimulated platelets is a combination of the effect of ADP at the P2Y12 receptor and of PGE1 at both IP and EP3 receptors. Adenosine Diphosphate 112-115 purinergic receptor P2Y12 Homo sapiens 123-128 23918456-0 2013 Pharmacokinetic study of adenosine diphosphate-encapsulated liposomes coated with fibrinogen gamma-chain dodecapeptide as a synthetic platelet substitute in an anticancer drug-induced thrombocytopenia rat model. Adenosine Diphosphate 25-46 fibrinogen gamma chain Rattus norvegicus 82-104 23918456-1 2013 A fibrinogen gamma-chain (dodecapeptide HHLGGAKQAGDV, H12)-coated, adenosine diphosphate (ADP)-encapsulated liposome [H12-(ADP)-liposome] was designed to achieve optimal performance as a homeostatic agent and expected as a synthetic platelet alternative. Adenosine Diphosphate 67-88 fibrinogen gamma chain Rattus norvegicus 2-24 23918456-1 2013 A fibrinogen gamma-chain (dodecapeptide HHLGGAKQAGDV, H12)-coated, adenosine diphosphate (ADP)-encapsulated liposome [H12-(ADP)-liposome] was designed to achieve optimal performance as a homeostatic agent and expected as a synthetic platelet alternative. Adenosine Diphosphate 90-93 fibrinogen gamma chain Rattus norvegicus 2-24 24118870-1 2013 BACKGROUND: The VerifyNow P2Y12 assay assesses the adequacy of clopidogrel therapy by measuring ADP-induced platelet activation in whole blood. Adenosine Diphosphate 96-99 purinergic receptor P2Y12 Homo sapiens 26-31 24118870-4 2013 PATIENTS/METHODS: Adenosine diphosphate-induced platelet activation was measured using the VerifyNow P2Y12 assay, whole blood impedance and light transmission platelet aggregometry (LTA) before and after clopidogrel loading in 113 patients undergoing elective cardiac catheterization. Adenosine Diphosphate 18-39 purinergic receptor P2Y12 Homo sapiens 101-106 23897816-3 2013 A distinguishing feature of ADF/cofilin is that it binds tighter to ADP-bound than to ATP-bound monomeric or filamentous actin. Adenosine Diphosphate 68-71 destrin, actin depolymerizing factor Homo sapiens 28-39 23917456-3 2013 Platelet P2Y12 receptor activation by adenosine diphosphate facilitates non-ADP agonist-mediated platelet aggregation, dense granule secretion, procoagulant activity, and the phosphorylation of several intraplatelet proteins, making it an ideal drug target. Adenosine Diphosphate 38-59 purinergic receptor P2Y12 Homo sapiens 9-14 23831058-5 2013 Abeta peptides also fasten platelet spreading on collagen, and support the time- and ADP-dependent activation of adherent platelets, leading to stimulation of several signalling proteins. Adenosine Diphosphate 85-88 succinate-CoA ligase ADP-forming subunit beta Homo sapiens 0-5 23850619-5 2013 This effect was abolished in the presence of the extracellular ADP scavenger system CP/CPK. Adenosine Diphosphate 63-66 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 87-90 29685928-2 2018 These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR1 or SUR2A/B) subunits, detect metabolic changes via three classes of intracellular adenine nucleotide (ATP/ADP) binding site. Adenosine Diphosphate 248-251 ATP binding cassette subfamily C member 8 Homo sapiens 137-141 23745751-6 2013 After ATP hydrolysis, spastin dissociates from MTs, and then exchanges ADP for ATP in solution for the next round of work. Adenosine Diphosphate 71-74 spastin Homo sapiens 22-29 23672398-6 2013 UNC-60A induces the depolymerization of actin filaments and sequesters actin monomers, whereas CAS-2 reverses the monomer-sequestering effect of UNC-60A in the presence of ATP, but not in the presence of only ADP or the absence of ATP or ADP. Adenosine Diphosphate 209-212 C-CAP/cofactor C-like domain-containing protein Caenorhabditis elegans 95-100 24474793-3 2014 Here we present the structures of the yeast ADP/ATP carriers Aac2p and Aac3p in the cytoplasmic state. Adenosine Diphosphate 44-47 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 61-66 24395786-5 2014 Compared with wild-type, UCP2-silenced human hepatocellular carcinoma (HepG2) cells, grown in the presence of glucose, showed a higher inner mitochondrial membrane potential and ATP:ADP ratio associated with a lower lactate release. Adenosine Diphosphate 182-185 uncoupling protein 2 Homo sapiens 25-29 23672398-6 2013 UNC-60A induces the depolymerization of actin filaments and sequesters actin monomers, whereas CAS-2 reverses the monomer-sequestering effect of UNC-60A in the presence of ATP, but not in the presence of only ADP or the absence of ATP or ADP. Adenosine Diphosphate 238-241 C-CAP/cofactor C-like domain-containing protein Caenorhabditis elegans 95-100 29685928-3 2018 One site, located on the Kir subunit, causes inhibition of the channel when ATP or ADP is bound. Adenosine Diphosphate 83-86 killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Homo sapiens 25-28 29604959-9 2018 The effects of isoform specific agonists and antagonists suggested that both P2Y1 and P2Y13 were obligatory for ADP responses, while P2Y4 and P2Y11 served as primary UTP and ATP receptors, respectively. Adenosine Diphosphate 112-115 purinergic receptor P2Y13 Homo sapiens 86-91 23859572-2 2013 PATIENTS & METHODS: The inhibition of adenosine diphosphate-induced platelet aggregation was measured pre- and post-administration using the VerifyNow( ) P2Y12 assay. Adenosine Diphosphate 42-63 purinergic receptor P2Y12 Homo sapiens 158-163 24465394-11 2014 In hepatocytes not only PST but also other GRP78-ATPase inhibitors (VER-155008 or ADP) increased G6Pase expression. Adenosine Diphosphate 82-85 dynein, axonemal, heavy chain 8 Mus musculus 49-55 24465394-11 2014 In hepatocytes not only PST but also other GRP78-ATPase inhibitors (VER-155008 or ADP) increased G6Pase expression. Adenosine Diphosphate 82-85 glucose-6-phosphatase, catalytic Mus musculus 97-103 29669825-8 2018 Both have two embedded regulatory transitions, one inhibiting ADP release and a second novel mechanism inhibiting actin detachment via strain on the actin-bound ELC N-terminus. Adenosine Diphosphate 62-65 myosin, light polypeptide 4 Mus musculus 161-164 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 HSPA (Hsp70) binding protein 1 Homo sapiens 0-23 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 HSPA (Hsp70) binding protein 1 Homo sapiens 25-31 23623170-6 2013 HRPR in response to adenosine diphosphate was seen in 150 (48.1%), 48 (15.3%), 106 (33.7%), and 118 (38.3%) patients by the VASP assay, LTA, the VerifyNow P2Y12 assay, and MEA, respectively. Adenosine Diphosphate 20-41 vasodilator stimulated phosphoprotein Homo sapiens 124-128 23623170-6 2013 HRPR in response to adenosine diphosphate was seen in 150 (48.1%), 48 (15.3%), 106 (33.7%), and 118 (38.3%) patients by the VASP assay, LTA, the VerifyNow P2Y12 assay, and MEA, respectively. Adenosine Diphosphate 20-41 purinergic receptor P2Y12 Homo sapiens 155-160 23716697-0 2013 Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Adenosine Diphosphate 64-67 C-terminal binding protein 1 Homo sapiens 84-89 23716697-0 2013 Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS. Adenosine Diphosphate 64-67 C-terminal binding protein 1 Homo sapiens 90-94 24850385-3 2014 Nevertheless, the AMPK system has been preserved in mammals where, by monitoring cellular AMP:adenosine triphosphate (ATP) and adenosine diphosphate (ADP):ATP ratios and balancing the rates of catabolism and ATP consumption, it maintains energy homeostasis at a cell-autonomous level. Adenosine Diphosphate 127-148 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-22 24850385-3 2014 Nevertheless, the AMPK system has been preserved in mammals where, by monitoring cellular AMP:adenosine triphosphate (ATP) and adenosine diphosphate (ADP):ATP ratios and balancing the rates of catabolism and ATP consumption, it maintains energy homeostasis at a cell-autonomous level. Adenosine Diphosphate 150-153 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 18-22 24187138-1 2013 AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs changes in the cellular energy balance represented by concentrations of AMP, ADP, and ATP. Adenosine Diphosphate 164-167 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-28 23716697-2 2013 We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP-ribosylation substrate (CtBP1-S/BARS), a bifunctional protein with roles in the nucleus as a transcription factor and in the cytosol as a regulator of membrane fission during intracellular trafficking and mitotic partitioning of the Golgi complex. Adenosine Diphosphate 73-76 C-terminal binding protein 1 Homo sapiens 93-121 29439388-2 2018 Platelet activation by ADP is associated with the G protein-coupled receptors P2Y1 and P2Y12. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 87-92 23716697-2 2013 We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP-ribosylation substrate (CtBP1-S/BARS), a bifunctional protein with roles in the nucleus as a transcription factor and in the cytosol as a regulator of membrane fission during intracellular trafficking and mitotic partitioning of the Golgi complex. Adenosine Diphosphate 73-76 C-terminal binding protein 1 Homo sapiens 165-170 23716697-2 2013 We previously showed that the fungal toxin brefeldin A (BFA) induces the ADP-ribosylation of C-terminal-binding protein-1 short-form/BFA-ADP-ribosylation substrate (CtBP1-S/BARS), a bifunctional protein with roles in the nucleus as a transcription factor and in the cytosol as a regulator of membrane fission during intracellular trafficking and mitotic partitioning of the Golgi complex. Adenosine Diphosphate 73-76 C-terminal binding protein 1 Homo sapiens 173-177 23716697-3 2013 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. Adenosine Diphosphate 21-24 C-terminal binding protein 1 Homo sapiens 41-46 23716697-3 2013 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. Adenosine Diphosphate 21-24 C-terminal binding protein 1 Homo sapiens 49-53 23716697-3 2013 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. Adenosine Diphosphate 21-24 C-terminal binding protein 1 Homo sapiens 269-274 23716697-3 2013 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. Adenosine Diphosphate 21-24 C-terminal binding protein 1 Homo sapiens 277-281 24187138-1 2013 AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that senses and governs changes in the cellular energy balance represented by concentrations of AMP, ADP, and ATP. Adenosine Diphosphate 164-167 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 30-34 24228848-6 2013 ADP binding to the ATPase was triggered by photolytic release of ADP from P(3)-1-(2-nitro)phenylethyl ADP (caged ADP). Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 19-25 24228848-6 2013 ADP binding to the ATPase was triggered by photolytic release of ADP from P(3)-1-(2-nitro)phenylethyl ADP (caged ADP). Adenosine Diphosphate 65-68 dynein axonemal heavy chain 8 Homo sapiens 19-25 24228848-6 2013 ADP binding to the ATPase was triggered by photolytic release of ADP from P(3)-1-(2-nitro)phenylethyl ADP (caged ADP). Adenosine Diphosphate 65-68 dynein axonemal heavy chain 8 Homo sapiens 19-25 29439388-6 2018 We evaluated the effect of tested flavonolignans on ADP-induced blood platelets" aggregation in platelet-rich plasma (PRP) (using light transmission aggregometry), adhesion to fibrinogen (using the static method), and the secretion of PF-4 (using the ELISA method). Adenosine Diphosphate 52-55 platelet factor 4 Homo sapiens 235-239 23695238-5 2013 The binding of the AtBAG1 BD to the Hsc70 NBD induces conformational change of the Hsc70 NBD to the open state and reduces the affinity of the NBD for ADP. Adenosine Diphosphate 151-154 heat shock cognate protein 70-1 Arabidopsis thaliana 36-41 24228848-11 2013 Upon phosphorylation of the ATPase, the beta-sheet relaxes back to a structure that is intermediate between that adopted in the ADP bound state and that in the ATP bound state. Adenosine Diphosphate 128-131 dynein axonemal heavy chain 8 Homo sapiens 28-34 23695238-5 2013 The binding of the AtBAG1 BD to the Hsc70 NBD induces conformational change of the Hsc70 NBD to the open state and reduces the affinity of the NBD for ADP. Adenosine Diphosphate 151-154 heat shock cognate protein 70-1 Arabidopsis thaliana 83-88 29416045-3 2018 Using mice with alpha-cell-specific inactivation of Gck (alphaGckKO mice), we find that glucokinase is required for the glucose-dependent increase in intracellular ATP/ADP ratio and the closure of KATP channels in alpha-cells and the suppression of glucagon secretion at euglycemic and hyperglycemic levels. Adenosine Diphosphate 168-171 glucokinase Mus musculus 88-99 24167279-9 2013 However, on account of SP-catalyzed ADP/ATP exchange, GroES symmetry is rapidly restored. Adenosine Diphosphate 36-39 heat shock protein family E (Hsp10) member 1 Homo sapiens 54-59 29410655-1 2018 MacroD1 is a macrodomain containing protein that has mono-ADP-ribose hydrolase enzymatic activity toward several ADP-ribose adducts. Adenosine Diphosphate 58-61 mono-ADP ribosylhydrolase 1 Homo sapiens 0-7 24003163-5 2013 Particularly significant among these secondary mediators is ADP, which, acting through platelet P2Y12 receptors, strongly amplifies aggregation. Adenosine Diphosphate 60-63 purinergic receptor P2Y12 Homo sapiens 96-101 23770670-8 2013 This report 1) identifies ADP-ribosylation as a new posttranslational modification for PEPCK, 2) describes a pathway by which transcriptional induction of TiPARP by the AHR can lead to a downstream posttranslational change in a TCDD target protein (PEPCK), and 3) reveals that the AHR exerts complex, previously unidentified modulatory effects on ADP-ribosylation. Adenosine Diphosphate 26-29 aryl hydrocarbon receptor Homo sapiens 169-172 23770670-8 2013 This report 1) identifies ADP-ribosylation as a new posttranslational modification for PEPCK, 2) describes a pathway by which transcriptional induction of TiPARP by the AHR can lead to a downstream posttranslational change in a TCDD target protein (PEPCK), and 3) reveals that the AHR exerts complex, previously unidentified modulatory effects on ADP-ribosylation. Adenosine Diphosphate 26-29 aryl hydrocarbon receptor Homo sapiens 281-284 23716691-3 2013 AMPK is activated by the rising ADP/ATP and AMP/ATP ratios during conditions of energy depletion and also by increasing intracellular Ca(2+). Adenosine Diphosphate 32-35 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 23321270-11 2013 ADP-induced platelet aggregation was suppressed by IL9, TGF-beta, IL4, and adiponectin. Adenosine Diphosphate 0-3 interleukin 9 Homo sapiens 51-54 23612493-2 2013 P2Y12 receptor is the major platelet receptor that mediates ADP-induced aggregation, P2Y12 receptor inhibitors such as clopidogrel and prasugrel inhibit platelet aggregation, and thus, they are used in the treatment and prevention of coronary artery disease. Adenosine Diphosphate 60-63 purinergic receptor P2Y12 Homo sapiens 0-5 23612493-2 2013 P2Y12 receptor is the major platelet receptor that mediates ADP-induced aggregation, P2Y12 receptor inhibitors such as clopidogrel and prasugrel inhibit platelet aggregation, and thus, they are used in the treatment and prevention of coronary artery disease. Adenosine Diphosphate 60-63 purinergic receptor P2Y12 Homo sapiens 85-90 23171128-1 2013 AIMS: Prasugrel is a novel thienopyridine P2Y12 adenosine diphosphate (ADP) receptor antagonist that inhibits ADP-mediated platelet activation and aggregation. Adenosine Diphosphate 71-74 purinergic receptor P2Y12 Homo sapiens 42-47 29410655-8 2018 Overall, we have shown that MacroD1 is a mitochondrial protein with promiscuous enzymatic activity that can target the ester bonds of ADP-ribosylated phosphorylated double-stranded DNA ends. Adenosine Diphosphate 134-137 mono-ADP ribosylhydrolase 1 Homo sapiens 28-35 23435863-2 2013 Current anti-platelet treatments are mainly based on inhibition of two important pathways of platelet activation: thromboxane A2 (TXA2) mediated (aspirin) and adenosine diphosphate (ADP)-P2Y12 receptor mediated (clopidogrel, prasugrel, and ticagrelor). Adenosine Diphosphate 159-180 purinergic receptor P2Y12 Homo sapiens 187-192 23427948-6 2012 In patients treated by KLP + ADP induced platelet aggregation correlated with VASP fosforylation. Adenosine Diphosphate 29-32 vasodilator stimulated phosphoprotein Homo sapiens 78-82 30346865-6 2018 P2Y12 inhibiting medications had increased ADP inhibition (p = 0.0077). Adenosine Diphosphate 43-46 purinergic receptor P2Y12 Homo sapiens 0-5 22611008-4 2012 The CD49f(H)CD41(H) MKPs purified by cytometry differentiated in vitro to produce proplatelets, independent of thrombopoietin stimulation, and they responded to stimulation with adenosine diphosphate, thrombin, and the PAR4 thrombin receptor-activating peptide. Adenosine Diphosphate 178-199 integrin alpha 6 Mus musculus 4-9 23485713-6 2013 Under hypotonicity, addition of 2-(methylthio)adenosine 5"-diphosphate (2MetSADP; ADP analog) increased RVD to the same extent as exposure to Na(+)-K(+)-ATPase and the same analog did not stimulate RVD when coincubated with MRS2211, a blocker of ADP receptor P2Y(13). Adenosine Diphosphate 77-80 purinergic receptor P2Y13 Homo sapiens 259-266 23485713-11 2013 Conversion of ATP(e) to ADP(e) by ENTPDase 2 activity facilitates the accumulated ADP(e) to activate P2Y(13) receptors, which mediate complete RVD. Adenosine Diphosphate 24-27 ATP synthase F1 subunit epsilon Homo sapiens 14-20 23485713-11 2013 Conversion of ATP(e) to ADP(e) by ENTPDase 2 activity facilitates the accumulated ADP(e) to activate P2Y(13) receptors, which mediate complete RVD. Adenosine Diphosphate 24-27 purinergic receptor P2Y13 Homo sapiens 101-108 30221575-5 2018 By next-generation sequencing, we searched for putative MLID-causative mutations in genes involved in methylation establishment/maintenance and found two novel missense mutations possibly causative of MLID: one in NLRP2, affecting ADP binding and protein activity, and one in ZFP42, likely leading to loss of DNA binding specificity. Adenosine Diphosphate 231-234 NLR family pyrin domain containing 2 Homo sapiens 214-219 23485713-11 2013 Conversion of ATP(e) to ADP(e) by ENTPDase 2 activity facilitates the accumulated ADP(e) to activate P2Y(13) receptors, which mediate complete RVD. Adenosine Diphosphate 82-85 ATP synthase F1 subunit epsilon Homo sapiens 14-20 23485713-11 2013 Conversion of ATP(e) to ADP(e) by ENTPDase 2 activity facilitates the accumulated ADP(e) to activate P2Y(13) receptors, which mediate complete RVD. Adenosine Diphosphate 82-85 purinergic receptor P2Y13 Homo sapiens 101-108 22841753-2 2012 Adenylate kinase (ADK) is responsible for the conversion of AMP (produced by the adenosine kinase reaction) into ADP, which is subsequently converted into ATP by nucleoside diphosphate kinase (NDPK). Adenosine Diphosphate 113-116 nucleoside diphosphate kinase Schistosoma mansoni 162-191 22841753-2 2012 Adenylate kinase (ADK) is responsible for the conversion of AMP (produced by the adenosine kinase reaction) into ADP, which is subsequently converted into ATP by nucleoside diphosphate kinase (NDPK). Adenosine Diphosphate 113-116 nucleoside diphosphate kinase Schistosoma mansoni 193-197 23340049-7 2013 Further, high on-treatment residual ADP-inducible platelet reactivity by the VASP assay and by MEA ADP were significantly more frequent in obese patients compared with nonobese patients (both P <= 0.04). Adenosine Diphosphate 36-39 vasodilator stimulated phosphoprotein Homo sapiens 77-81 30221575-5 2018 By next-generation sequencing, we searched for putative MLID-causative mutations in genes involved in methylation establishment/maintenance and found two novel missense mutations possibly causative of MLID: one in NLRP2, affecting ADP binding and protein activity, and one in ZFP42, likely leading to loss of DNA binding specificity. Adenosine Diphosphate 231-234 ZFP42 zinc finger protein Homo sapiens 276-281 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 39-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 23387322-1 2013 P2Y12 receptor internalization and recycling play an essential role in ADP-induced platelet activation. Adenosine Diphosphate 71-74 purinergic receptor P2Y12 Homo sapiens 0-5 23387322-4 2013 Treatment with ADP resulted in delayed Rab5-dependent internalization of P341A when compared with WT P2Y12 . Adenosine Diphosphate 15-18 purinergic receptor P2Y12 Homo sapiens 101-106 22891849-7 2012 We present two new crystal structures of CDK2 bound to ADP showing how the phosphate groups can be coordinated by either one or two Mg(2+) ions, with the occupancy of one site in a weaker equilibrium. Adenosine Diphosphate 55-58 cyclin dependent kinase 2 Homo sapiens 41-45 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 69-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 29343628-6 2018 AMPK is activated by increasing AMP or ADP (AMP being generated from ADP whenever ADP rises) coupled with falling ATP. Adenosine Diphosphate 69-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22451668-0 2012 Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2. Adenosine Diphosphate 96-99 ATP binding cassette subfamily C member 8 Homo sapiens 61-65 22362759-3 2012 We investigated the mechanism and specific isoforms involved in PKC-mediated negative regulation of ADP-induced functional responses. Adenosine Diphosphate 100-103 protein kinase C, epsilon Mus musculus 64-67 22362759-4 2012 METHODS AND RESULTS: A pan-PKC inhibitor, GF109203X, potentiated ADP-induced cPLA(2) phosphorylation and thromboxane generation as well as ERK activation and intracellular calcium (Ca(2+)(i)) mobilization, 2 signaling molecules, upstream of cPLA(2) activation. Adenosine Diphosphate 65-68 protein kinase C, epsilon Mus musculus 27-30 22362759-7 2012 ADP-induced thromboxane generation, calcium mobilization, and ERK phosphorylation were potentiated in PKCepsilon null murine platelets compared with platelets from wild-type littermates. Adenosine Diphosphate 0-3 protein kinase C, epsilon Mus musculus 102-112 23444389-10 2013 It was observed that Rb1 increased the ratio of intracellular ATP to ADP concentration and intracellular Ca2+ concentration. Adenosine Diphosphate 69-72 RB transcriptional corepressor 1 Homo sapiens 21-24 23490430-2 2013 ADP induces platelet aggregation through two purinergic receptors P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 75-80 23490430-9 2013 Under P2Y1 blockade, citalopram inhibited platelet aggregation and integrin alphaIIbbeta3 activation in response to ADP, indicating that citalopram inhibited P2Y12-mediated aggregation. Adenosine Diphosphate 116-119 purinergic receptor P2Y12 Homo sapiens 158-163 23490430-10 2013 Citalopram concentration-dependently inhibited the phosphorylation of Akt, GSK3beta, p38 MAPK and Syk induced by ADP, but showed no effect on the decrease of cAMP and VASP phosphorylation. Adenosine Diphosphate 113-116 glycogen synthase kinase 3 beta Homo sapiens 75-83 23490430-12 2013 Taken together, under the stimulation of ADP, SSRIs inhibit the amplification of platelet aggregation secondary to the activation of P2Y12 receptor, and subsequently reduce the activation of the downstream molecules of the outside-in signaling pathways. Adenosine Diphosphate 41-44 purinergic receptor P2Y12 Homo sapiens 133-138 22362759-8 2012 Interestingly, when thromboxane release is blocked, ADP-induced aggregation in PKCepsilon knockout and wild-type was similar, suggesting that PKCepsilon does not affect ADP-induced aggregation directly. Adenosine Diphosphate 52-55 protein kinase C, epsilon Mus musculus 79-89 22362759-10 2012 CONCLUSIONS: We conclude that PKCepsilon negatively regulates ADP-induced thromboxane generation in platelets and offers protection against thrombosis. Adenosine Diphosphate 62-65 protein kinase C, epsilon Mus musculus 30-40 29343628-8 2018 Structural studies have illuminated how AMPK achieves the task of detecting small changes in AMP and ADP, despite the presence of much higher concentrations of ATP. Adenosine Diphosphate 101-104 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 40-44 29480469-1 2018 AMP-activated protein kinase (AMPK) is an energy sensor that is activated by increases in the cellular AMP/ATP and ADP/ATP ratios by three mechanisms: (1) allosteric activation, (2) promotion of phosphorylation at Thr172 on the alpha subunit by upstream kinases, and (3) inhibition of dephosphorylation of Thr172 by protein phosphatases. Adenosine Diphosphate 115-118 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 22269791-1 2012 UNLABELLED: CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine, an anti-thrombotic and cardiovascular protective mediator. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 12-16 22269791-1 2012 UNLABELLED: CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine, an anti-thrombotic and cardiovascular protective mediator. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 18-66 22269791-1 2012 UNLABELLED: CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD-1) rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine, an anti-thrombotic and cardiovascular protective mediator. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Sus scrofa 68-75 29480469-1 2018 AMP-activated protein kinase (AMPK) is an energy sensor that is activated by increases in the cellular AMP/ATP and ADP/ATP ratios by three mechanisms: (1) allosteric activation, (2) promotion of phosphorylation at Thr172 on the alpha subunit by upstream kinases, and (3) inhibition of dephosphorylation of Thr172 by protein phosphatases. Adenosine Diphosphate 115-118 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 29188558-2 2018 We illustrate here how this applies to A2A adenosine receptors (ARs) and to P2Y1 and P2Y12 receptors (P2YRs) for ADP. Adenosine Diphosphate 113-116 purinergic receptor P2Y12 Homo sapiens 85-90 22219026-1 2012 A novel murine enzyme, ADP-dependent glucokinase (ADPGK), has been shown to catalyse glucose phosphorylation using ADP as phosphoryl donor. Adenosine Diphosphate 23-26 ADP-dependent glucokinase Mus musculus 50-55 29286281-7 2017 These structures support the role of SUR1 as an ADP sensor and highlight the lasso extension as a key regulatory element in ADP"s ability to override ATP inhibition. Adenosine Diphosphate 48-51 ATP binding cassette subfamily C member 8 Homo sapiens 37-41 22362712-6 2012 Further, a 3.1-A crystal structure of IPK1 bound to ADP in the absence of IP revealed decreased order in residues 110-140 within the N-lobe of the kinase compared with structures in which IP is bound. Adenosine Diphosphate 52-55 inositol-pentakisphosphate 2-kinase Homo sapiens 38-42 29286281-7 2017 These structures support the role of SUR1 as an ADP sensor and highlight the lasso extension as a key regulatory element in ADP"s ability to override ATP inhibition. Adenosine Diphosphate 124-127 ATP binding cassette subfamily C member 8 Homo sapiens 37-41 29158484-4 2017 In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci. Adenosine Diphosphate 51-54 heat shock transcription factor 1 Homo sapiens 90-94 22185573-4 2012 Its transport properties and kinetic parameters demonstrate that SLC25A17 is a transporter of CoA, FAD, FMN and AMP, and to a lesser extent of NAD+, PAP (adenosine 3",5"-diphosphate) and ADP. Adenosine Diphosphate 187-190 solute carrier family 25 member 17 Homo sapiens 65-73 28822683-4 2017 ADP acts as a strong ATPase inhibitor of cytosol-specific Hsp90 homologs, whereas organellular Hsp90 homologs (Grp94 and TRAP1) are relatively insensitive to the presence of ADP. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 21-27 22015608-0 2012 SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering. Adenosine Diphosphate 101-104 solute carrier family 25 member 24 Homo sapiens 0-7 28504211-2 2017 On hepatocytes, apoA-I binding to ecto-F1-ATPase stimulates extracellular ATP hydrolysis into ADP, which subsequently activates a P2Y13-mediated HDL endocytosis pathway. Adenosine Diphosphate 94-97 tripartite motif containing 33 Homo sapiens 34-38 22183178-4 2012 An essential part in the platelet activation process is the interaction of adenosine diphosphate (ADP) with the platelet P2Y12 receptor. Adenosine Diphosphate 75-96 purinergic receptor P2Y12 Homo sapiens 121-126 22183178-4 2012 An essential part in the platelet activation process is the interaction of adenosine diphosphate (ADP) with the platelet P2Y12 receptor. Adenosine Diphosphate 98-101 purinergic receptor P2Y12 Homo sapiens 121-126 22183178-5 2012 The P2Y12 receptor is the predominant receptor involved in the ADP-stimulated activation of the glycoprotein IIb/IIIa receptor. Adenosine Diphosphate 63-66 purinergic receptor P2Y12 Homo sapiens 4-9 21979433-8 2012 Both in the presence and absence of ADP inhibition of the purinergic receptor P2Y(12) but not P2Y(1) decreased the cell association of apoA-I and HDL. Adenosine Diphosphate 36-39 purinergic receptor P2Y12 Homo sapiens 58-85 21979433-11 2012 CONCLUSIONS: Binding of apoA-I to ectopic F(0)F(1) ATPase triggers the generation of ADP, which via activation of the purinergic receptor P2Y(12) stimulates the uptake and transport of HDL and initially lipid-free apoA-I by endothelial cells. Adenosine Diphosphate 85-88 ATP synthase F1 subunit epsilon Homo sapiens 42-57 21979433-11 2012 CONCLUSIONS: Binding of apoA-I to ectopic F(0)F(1) ATPase triggers the generation of ADP, which via activation of the purinergic receptor P2Y(12) stimulates the uptake and transport of HDL and initially lipid-free apoA-I by endothelial cells. Adenosine Diphosphate 85-88 purinergic receptor P2Y12 Homo sapiens 118-145 21736422-7 2012 Furthermore, while succinate alone had no effect in the presence of platelet inhibitors, responsiveness of platelets to ADP after pretreatment with P2Y(1) or P2Y(12) antagonists was fully restored, when platelets were co-stimulated with 100 microM succinate. Adenosine Diphosphate 120-123 purinergic receptor P2Y12 Homo sapiens 158-165 22590634-5 2012 ADP affects autophagy and apoA-I secretion through P2Y(13). Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 51-58 28504211-2 2017 On hepatocytes, apoA-I binding to ecto-F1-ATPase stimulates extracellular ATP hydrolysis into ADP, which subsequently activates a P2Y13-mediated HDL endocytosis pathway. Adenosine Diphosphate 94-97 purinergic receptor P2Y13 Homo sapiens 130-135 22590634-8 2012 P2Y(13) gene silencing blocks the effects of ADP on autophagy and apoA-I secretion. Adenosine Diphosphate 45-48 purinergic receptor P2Y13 Homo sapiens 0-7 28504211-6 2017 We then showed that ecto-ANT activity increases or reduces extracellular ADP level, depending on the extracellular ADP/ATP ratio. Adenosine Diphosphate 73-76 tripartite motif containing 33 Homo sapiens 20-24 28504211-6 2017 We then showed that ecto-ANT activity increases or reduces extracellular ADP level, depending on the extracellular ADP/ATP ratio. Adenosine Diphosphate 115-118 tripartite motif containing 33 Homo sapiens 20-24 28504211-7 2017 Interestingly, ecto-ANT co-localized with ecto-F1-ATPase at the hepatocyte plasma membrane and pharmacological inhibition of ecto-ANT activity increased extracellular ADP level when ecto-F1-ATPase was activated by apoA-I. Adenosine Diphosphate 167-170 tripartite motif containing 33 Homo sapiens 15-19 27848264-2 2017 We hypothesized that red cell adenosine diphosphate (ADP) release results in significant platelet activation in hemolysis and that this prothrombotic state can be prevented by inhibition of the ADP P2Y12 receptor. Adenosine Diphosphate 30-51 purinergic receptor P2Y12 Homo sapiens 198-203 22427795-6 2012 Mitochondrial ADP consumption by succinate-induced respiration was 26% higher in UCP4-overexpressing cells, with 20% higher ADP:O ratio (p<0.05). Adenosine Diphosphate 14-17 solute carrier family 25 member 27 Homo sapiens 81-85 22427795-6 2012 Mitochondrial ADP consumption by succinate-induced respiration was 26% higher in UCP4-overexpressing cells, with 20% higher ADP:O ratio (p<0.05). Adenosine Diphosphate 124-127 solute carrier family 25 member 27 Homo sapiens 81-85 28615457-2 2017 AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP to three sites (CBS1, CBS3, and CBS4) in its gamma-subunit. Adenosine Diphosphate 102-105 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 21994945-2 2011 We report the molecular identification of the eukaryotic dehydratase that repairs these nucleotides and show that this enzyme (Carkd in mammals, YKL151C in yeast) catalyzes the dehydration of the S form of NADHX and NADPHX, at the expense of ATP, which is converted to ADP. Adenosine Diphosphate 217-220 NADHX dehydratase Saccharomyces cerevisiae S288C 145-152 28360103-4 2017 This deregulation can explain the mitochondrial uncoupling and lower ATP levels in VCP mutation-bearing neurons via reduced ADP availability for ATP synthesis. Adenosine Diphosphate 124-127 valosin containing protein Homo sapiens 83-86 22065753-2 2011 Using solution NMR, we obtained a three-dimensional structure for a 75-kDa Hsp70-DnaJ complex in the ADP state, loaded with substrate peptide. Adenosine Diphosphate 101-104 DnaJ heat shock protein family (Hsp40) member C14 Homo sapiens 81-85 28618520-1 2017 F_{o}F_{1}-ATPase is a motor protein complex that utilizes transmembrane ion flow to drive the synthesis of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and phosphate (Pi). Adenosine Diphosphate 142-163 dynein axonemal heavy chain 8 Homo sapiens 11-17 22035583-6 2011 Alanine substitution of two amino acids, aspartic acid 127 and histidine 196 within the 5"-nucleotidase signature sequence, leads to reduced AMP or ADP hydrolysis but does not affect the binding of these substrates. Adenosine Diphosphate 148-151 5'-nucleotidase ecto Homo sapiens 88-103 23652405-4 2013 RESULTS: Our data show time-dependent platelet activation by GPVI agonist (collagen related peptide; CRP), PAR-1 agonist (SFLLRN), P2Y12 agonist (ADP), and thromboxane receptor agonist (U46619) in a platelet concentrate. Adenosine Diphosphate 146-149 purinergic receptor P2Y12 Homo sapiens 131-136 28618520-1 2017 F_{o}F_{1}-ATPase is a motor protein complex that utilizes transmembrane ion flow to drive the synthesis of adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and phosphate (Pi). Adenosine Diphosphate 165-168 dynein axonemal heavy chain 8 Homo sapiens 11-17 28100692-3 2017 In this study, we have determined crystal structures of the core helicase domain of RECQL5 both with and without the nucleotide ADP in two distinctly different ("Open" and "Closed") conformations. Adenosine Diphosphate 128-131 helicase for meiosis 1 Homo sapiens 65-73 23458248-9 2013 Loss of Mg1 may thus be an important part of the rate-limiting step of ADP release. Adenosine Diphosphate 71-74 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 8-11 23345595-3 2013 Dimeric yeast Mge1, the cochaperone of heat shock protein 70 (Hsp70), is essential for exchanging ATP for ADP on Hsp70 and thus for recycling of Hsp70 for mitochondrial protein import and folding. Adenosine Diphosphate 106-109 Mge1p Saccharomyces cerevisiae S288C 14-18 21442609-8 2011 In addition, NMA demonstrated that the "rocking" of the N- and C-terminal domains of GSK3beta, which coordinates the mutual movement of both lobes, inducing the opening and closing of the active site of GSK3beta, which may assist the entry of ATP into the ATP binding site and the release of the ADP product. Adenosine Diphosphate 296-299 glycogen synthase kinase 3 beta Homo sapiens 85-93 21442609-8 2011 In addition, NMA demonstrated that the "rocking" of the N- and C-terminal domains of GSK3beta, which coordinates the mutual movement of both lobes, inducing the opening and closing of the active site of GSK3beta, which may assist the entry of ATP into the ATP binding site and the release of the ADP product. Adenosine Diphosphate 296-299 glycogen synthase kinase 3 beta Homo sapiens 203-211 28100692-3 2017 In this study, we have determined crystal structures of the core helicase domain of RECQL5 both with and without the nucleotide ADP in two distinctly different ("Open" and "Closed") conformations. Adenosine Diphosphate 128-131 RecQ like helicase 5 Homo sapiens 84-90 28389215-4 2017 Basal ATP/ADP ratios in MIP-E4BP4 islets were elevated without the circadian oscillations observed in wild-type islets. Adenosine Diphosphate 10-13 nuclear factor, interleukin 3, regulated Mus musculus 28-33 21621250-4 2011 PATIENTS AND METHODS: Adenosine diphosphate (ADP)-inducible platelet reactivity was assessed by light transmission aggregometry (LTA), the VerifyNow P2Y12 assay, the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay, multiple electrode aggregometry (MEA), and the Impact-R in 288 patients after angioplasty and stenting for cardiovascular disease. Adenosine Diphosphate 22-43 purinergic receptor P2Y12 Homo sapiens 149-154 21621250-4 2011 PATIENTS AND METHODS: Adenosine diphosphate (ADP)-inducible platelet reactivity was assessed by light transmission aggregometry (LTA), the VerifyNow P2Y12 assay, the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay, multiple electrode aggregometry (MEA), and the Impact-R in 288 patients after angioplasty and stenting for cardiovascular disease. Adenosine Diphosphate 22-43 vasodilator stimulated phosphoprotein Homo sapiens 205-209 21621250-4 2011 PATIENTS AND METHODS: Adenosine diphosphate (ADP)-inducible platelet reactivity was assessed by light transmission aggregometry (LTA), the VerifyNow P2Y12 assay, the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay, multiple electrode aggregometry (MEA), and the Impact-R in 288 patients after angioplasty and stenting for cardiovascular disease. Adenosine Diphosphate 45-48 purinergic receptor P2Y12 Homo sapiens 149-154 21621250-4 2011 PATIENTS AND METHODS: Adenosine diphosphate (ADP)-inducible platelet reactivity was assessed by light transmission aggregometry (LTA), the VerifyNow P2Y12 assay, the vasodilator-stimulated phosphoprotein (VASP) phosphorylation assay, multiple electrode aggregometry (MEA), and the Impact-R in 288 patients after angioplasty and stenting for cardiovascular disease. Adenosine Diphosphate 45-48 vasodilator stimulated phosphoprotein Homo sapiens 205-209 21904029-5 2011 ADP-bound PDK4 has a slightly wider active-site cleft and a more disordered ATP lid compared with AMPPNP-bound PDK4, although both forms of PDK4 assume open conformations with a wider active-site cleft than that in the closed conformation of the previously reported ADP-bound PDK2 structure. Adenosine Diphosphate 0-3 pyruvate dehydrogenase kinase 2 Homo sapiens 276-280 21808051-6 2011 With ADP present, myoVI acts as an anchor to prevent myoV from stepping forward. Adenosine Diphosphate 5-8 myosin VI Homo sapiens 18-23 21352099-5 2011 NNMT expression significantly decreased SH-SY5Y cell death, which correlated with increased intracellular ATP content, ATP/ADP ratio and Complex I activity, and a reduction in the degradation of the NDUFS3 [NADH dehydrogenase (ubiquinone) iron-sulfur protein 3] subunit of Complex I. Adenosine Diphosphate 123-126 nicotinamide N-methyltransferase Homo sapiens 0-4 21352099-7 2011 Both NNMT expression and 1-methylnicotinamide protected SH-SY5Y cells from the toxicity of the Complex I inhibitors MPP+ (1-methyl-4-phenylpyridinium ion) and rotenone by reversing their effects upon ATP synthesis, the ATP/ADP ratio, Complex I activity and the NDUFS3 subunit. Adenosine Diphosphate 223-226 nicotinamide N-methyltransferase Homo sapiens 5-9 21565702-1 2011 We have determined high-resolution crystal structures of a CDK2/Cyclin A transition state complex bound to ADP, substrate peptide, and MgF(3)(-). Adenosine Diphosphate 107-110 cyclin dependent kinase 2 Homo sapiens 59-63 21295139-1 2011 SUCLA2-related mitochondrial DNA (mtDNA) depletion syndrome is a result of mutations in the beta subunit of the ADP-dependent isoform of the Krebs cycle succinyl-CoA synthase (SCS). Adenosine Diphosphate 112-115 succinate-CoA ligase ADP-forming subunit beta Homo sapiens 0-6 21479342-0 2011 Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate. Adenosine Diphosphate 98-119 purinergic receptor P2Y12 Homo sapiens 79-84 21479342-1 2011 P2Y12, one of the two platelet receptors for adenosine diphosphate (ADP), plays a central role in platelet function. Adenosine Diphosphate 45-66 purinergic receptor P2Y12 Homo sapiens 0-5 21479342-1 2011 P2Y12, one of the two platelet receptors for adenosine diphosphate (ADP), plays a central role in platelet function. Adenosine Diphosphate 68-71 purinergic receptor P2Y12 Homo sapiens 0-5 21479342-2 2011 Defects of P2Y12 should be suspected when ADP, even at high concentrations (>=10 microM), is unable to induce full, irreversible platelet aggregation. Adenosine Diphosphate 42-45 purinergic receptor P2Y12 Homo sapiens 11-16 21317046-7 2011 Indeed we demonstrated that Che-1 protein co-immunoprecipitates with ADP-ribose polymers and that PARP-1 directly interacts with Che-1, promoting its modification in vitro and in vivo. Adenosine Diphosphate 69-72 apoptosis antagonizing transcription factor Homo sapiens 28-33 23203294-1 2013 The conformational changes in myosin associated with ADP release and their influence on actin sliding velocity are not understood. Adenosine Diphosphate 53-56 Myosin light chain cytoplasmic Drosophila melanogaster 30-36 23203294-2 2013 Following actin binding, the myosin active site is in equilibrium between a closed and open ADP bound state, with the open state previously thought to favor ADP release and thus expected to be favored in faster myosins. Adenosine Diphosphate 92-95 Myosin light chain cytoplasmic Drosophila melanogaster 29-35 23203294-2 2013 Following actin binding, the myosin active site is in equilibrium between a closed and open ADP bound state, with the open state previously thought to favor ADP release and thus expected to be favored in faster myosins. Adenosine Diphosphate 157-160 Myosin light chain cytoplasmic Drosophila melanogaster 29-35 22879063-2 2013 P2Y(1) and P2Y(12) both respond to ADP, but while P2Y(1) links to PLC and elevates cytosolic Ca(2+) concentration, P2Y(12) negatively couples to adenylate cyclase, maintaining cAMP at low level. Adenosine Diphosphate 35-38 purinergic receptor P2Y12 Homo sapiens 11-18 22879063-4 2013 During prolonged serum deprivation, cell growth is arrested, the expression of the P2Y(1) receptor strongly decreases and P2Y(12) becomes a major player responsible for ADP-evoked signal transduction. Adenosine Diphosphate 169-172 purinergic receptor P2Y12 Homo sapiens 122-129 23958191-13 2013 CONCLUSIONS: We have optimised the HTRF Transcreener ADP assay for high-throughput screening to identify PMCA4 inhibitors. Adenosine Diphosphate 55-58 ATPase plasma membrane Ca2+ transporting 4 Homo sapiens 107-112 24352254-1 2013 AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-28 24352254-1 2013 AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy balance by sensing and responding to increases in AMP/ADP concentration relative to ATP. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 30-34 23216528-8 2013 Adenosine diphosphate (ADP) induced platelet reactivity was determined by VerifyNow P2Y12 assay, by light transmission aggregometry (LTA) and by multiple electrode impedance aggregometry (MEIA; Multiplate analyser). Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 85-90 23216528-8 2013 Adenosine diphosphate (ADP) induced platelet reactivity was determined by VerifyNow P2Y12 assay, by light transmission aggregometry (LTA) and by multiple electrode impedance aggregometry (MEIA; Multiplate analyser). Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 85-90 23658513-2 2013 A subpopulation of human Treg expresses the ectoenzyme CD39, which in association with CD73 converts ATP/ADP/AMP to adenosine. Adenosine Diphosphate 105-108 5'-nucleotidase ecto Homo sapiens 87-91 22930330-5 2012 In MV the rate-limiting step for both in vitro motility and ATPase assays is known to be ADP release. Adenosine Diphosphate 89-92 dynein axonemal heavy chain 8 Homo sapiens 60-66 28205519-2 2017 Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver. Adenosine Diphosphate 47-50 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 0-30 23083103-0 2012 Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation. Adenosine Diphosphate 104-107 purinergic receptor P2Y12 Homo sapiens 72-77 28205519-2 2017 Adenine nucleotide translocase (ANT) exchanges ADP/ATP through the mitochondrial inner membrane, and Ant2 is the predominant isoform expressed in the liver. Adenosine Diphosphate 47-50 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 32-35 27794044-3 2017 We found that under these and adenosine diphosphate (ADP)-generating suppressive conditions for the recombinase activity, RecA or Rad51 at similar optimal concentrations enhances the DNA ligase-catalyzed dsDNA end-joining (DNA ligation) about 30- to 40-fold. Adenosine Diphosphate 30-51 recombinase RAD51 Saccharomyces cerevisiae S288C 130-135 22945555-2 2012 A fluorescent reporter "poly 1-(3-((4-methylthiophen-3-yl)oxy)propyl)quinuclidin-1-ium" (poly PTQ) is used to monitor the hydrolysis of ATP to ADP by p97/VCP. Adenosine Diphosphate 143-146 valosin containing protein Homo sapiens 150-153 22945555-2 2012 A fluorescent reporter "poly 1-(3-((4-methylthiophen-3-yl)oxy)propyl)quinuclidin-1-ium" (poly PTQ) is used to monitor the hydrolysis of ATP to ADP by p97/VCP. Adenosine Diphosphate 143-146 valosin containing protein Homo sapiens 154-157 22689668-1 2012 BACKGROUND: The interaction of adenosine diphosphate with its P2Y(1) and P2Y(12) receptors on platelets is important for platelet function. Adenosine Diphosphate 31-52 purinergic receptor P2Y12 Homo sapiens 73-80 22689668-7 2012 Since cangrelor and 2-MeSAMP also interact with P2Y(13), we hypothesized that P2Y(13), rather than P2Y(12) is involved in adenosine diphosphate-regulated proplatelet formation. Adenosine Diphosphate 122-143 purinergic receptor P2Y13 Homo sapiens 78-85 22689668-11 2012 CONCLUSIONS: This is the first demonstration that adenosine diphosphate released by megakaryocytes regulates their function by interacting with P2Y(13). Adenosine Diphosphate 50-71 purinergic receptor P2Y13 Homo sapiens 144-151 27794044-3 2017 We found that under these and adenosine diphosphate (ADP)-generating suppressive conditions for the recombinase activity, RecA or Rad51 at similar optimal concentrations enhances the DNA ligase-catalyzed dsDNA end-joining (DNA ligation) about 30- to 40-fold. Adenosine Diphosphate 53-56 recombinase RAD51 Saccharomyces cerevisiae S288C 130-135 22802590-4 2012 The ATPase activity of purified SUR1-NBD2-G1410R (bound to maltose-binding protein) was slightly inhibited when compared to the wild-type protein, but its inhibition by MgADP was unchanged, indicating that MgADP binding is not altered. Adenosine Diphosphate 169-174 ATP binding cassette subfamily C member 8 Homo sapiens 32-36 27794044-4 2017 The DNA ligation enhancement by RecA or Rad51 transforms most of the substrate DNA into multimers within 2-5 min, and for this enhancement, ADP is the common and best cofactor. Adenosine Diphosphate 140-143 recombinase RAD51 Saccharomyces cerevisiae S288C 40-45 22802590-4 2012 The ATPase activity of purified SUR1-NBD2-G1410R (bound to maltose-binding protein) was slightly inhibited when compared to the wild-type protein, but its inhibition by MgADP was unchanged, indicating that MgADP binding is not altered. Adenosine Diphosphate 206-211 ATP binding cassette subfamily C member 8 Homo sapiens 32-36 28004795-2 2016 Here we demonstrate by nucleotide turnover and binding studies based on 31P solid-state NMR spectroscopy that the ABC exporter and lipid A flippase MsbA can couple ATP hydrolysis to an adenylate kinase activity, where ADP is converted into AMP and ATP. Adenosine Diphosphate 218-221 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 114-117 22996695-7 2012 In platelets, ADP stimulation of P2RY12 resulted in GTPase Ras-related protein (RAP1) activation and subsequent alphaIIbbeta3 integrin activation. Adenosine Diphosphate 14-17 RAS-related protein 1a Mus musculus 80-84 22996695-8 2012 Likewise, we found that ADP stimulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its effects were substantially blunted in P2ry12-/- OCs. Adenosine Diphosphate 24-27 RAS-related protein 1a Mus musculus 48-52 23085732-0 2012 The Arabidopsis thylakoid ADP/ATP carrier TAAC has an additional role in supplying plastidic phosphoadenosine 5"-phosphosulfate to the cytosol. Adenosine Diphosphate 26-29 thylakoid ATP/ADP carrier Arabidopsis thaliana 42-46 23085732-4 2012 We present several lines of evidence that the recently described Arabidopsis thaliana thylakoid ADP/ATP carrier TAAC transports PAPS across the plastid envelope and thus fulfills an additional function of high physiological relevance. Adenosine Diphosphate 96-99 thylakoid ATP/ADP carrier Arabidopsis thaliana 112-116 22857951-5 2012 Dcx specifically enhances binding of the ADP-bound Kif1a motor domain to MTs. Adenosine Diphosphate 41-44 doublecortin Homo sapiens 0-3 22814751-0 2012 ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3beta. Adenosine Diphosphate 0-3 glycogen synthase kinase 3 beta Homo sapiens 112-142 22674577-2 2012 The cycling of ParF between ADP- and ATP-bound states drives TP228 partition; ATP binding stimulates ParF polymerization, which is essential for segregation, whereas ADP binding antagonizes polymerization and inhibits DNA partition. Adenosine Diphosphate 28-31 RAB, member RAS oncogene family like 6 Homo sapiens 15-19 22674577-2 2012 The cycling of ParF between ADP- and ATP-bound states drives TP228 partition; ATP binding stimulates ParF polymerization, which is essential for segregation, whereas ADP binding antagonizes polymerization and inhibits DNA partition. Adenosine Diphosphate 166-169 RAB, member RAS oncogene family like 6 Homo sapiens 15-19 22674577-5 2012 Here, we describe multiple ParF structures in ADP- and phosphomethylphosphonic acid adenylate ester (AMPPCP)-bound states. Adenosine Diphosphate 46-49 RAB, member RAS oncogene family like 6 Homo sapiens 27-31 22773752-5 2012 BEX5/RabA1b localizes to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking processes like those regulated by GTP exchange factors on ADP-ribosylation factors GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1, which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. Adenosine Diphosphate 161-164 GNOM-like 1 Arabidopsis thaliana 186-196 22627684-1 2012 Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. Adenosine Diphosphate 190-193 haptoglobin-related protein Homo sapiens 195-198 22675116-2 2012 During its ATPase cycle p97 functions as an ATP motor, converting the chemical energy released upon hydrolysis of ATP to ADP into mechanical work, which is then directed toward the proteins that serve as substrates. Adenosine Diphosphate 121-124 dynein axonemal heavy chain 8 Homo sapiens 11-17 22415305-4 2012 Increased overexpression of cN-IA led to reductions in the oligomycin-induced increases in AMP and ADP concentrations by ~70 and 50%, respectively, concomitant with a 50% decrease in AMPK activation. Adenosine Diphosphate 99-102 5'-nucleotidase, cytosolic IA Homo sapiens 28-33 22542467-4 2012 In cardiac mitochondria isolated from transgenic (TG) mice with cardiac-specific overexpression of Hsp22, mitochondrial basal, ADP-dependent, and uncoupled O2 consumption was increased in the presence of either glucidic or lipidic substrates. Adenosine Diphosphate 127-130 heat shock protein 8 Mus musculus 99-104 22503564-9 2012 Significant correlations were observed between ADP-induced platelet aggregation assessed by VASP-phosphorylation and by impedance aggregometry. Adenosine Diphosphate 47-50 vasodilator stimulated phosphoprotein Homo sapiens 92-96 22284532-2 2012 Recent discoveries demonstrate that AMPK is activated primarily by rising ADP levels and not, as previously thought, by AMP. Adenosine Diphosphate 74-77 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 36-40 22284532-3 2012 AMPK activation is dependent on ADP-controlled phosphorylation of Thr172 on its activation loop, a mechanism of protein regulation that represents an example of an allosterically regulated modification (ARM). Adenosine Diphosphate 32-35 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22178987-9 2012 ADP, 2-methylthioadenosine-5"-O-diphosphate (2-MeSADP), or UTP decreased the electrically evoked ir-CGRP overflow, whereas clonidine, alpha,beta-methyleneadenosine 5"-triphosphate (alpha,beta-mATP), or adenosine (ADO) were inactive. Adenosine Diphosphate 0-3 calcitonin-related polypeptide alpha Rattus norvegicus 100-104 22135310-8 2012 In the presence of NTPDase8 and CD73, ATP was sequentially dephosphorylated to the CD73 inhibitor ADP, and then to AMP, thus resulting in a delayed formation of adenosine. Adenosine Diphosphate 98-101 ectonucleoside triphosphate diphosphohydrolase 8 Rattus norvegicus 19-27 22135310-8 2012 In the presence of NTPDase8 and CD73, ATP was sequentially dephosphorylated to the CD73 inhibitor ADP, and then to AMP, thus resulting in a delayed formation of adenosine. Adenosine Diphosphate 98-101 5' nucleotidase, ecto Rattus norvegicus 32-36 22135310-8 2012 In the presence of NTPDase8 and CD73, ATP was sequentially dephosphorylated to the CD73 inhibitor ADP, and then to AMP, thus resulting in a delayed formation of adenosine. Adenosine Diphosphate 98-101 5' nucleotidase, ecto Rattus norvegicus 83-87 22075250-8 2012 Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12-dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively. Adenosine Diphosphate 179-182 purinergic receptor P2Y12 Homo sapiens 98-103 22322891-12 2012 These results suggest that mitochondrially bound HK supporting the ADP/ATP exchange activity levels facilitates the 3-BrPA inhibition reaction in tumors mitochondria by a proton motive force-dependent dynamic equilibrium between sensitive and less sensitive SDH in the electron transport system. Adenosine Diphosphate 67-70 serine dehydratase Homo sapiens 258-261 21106949-0 2011 Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 101-106 21106949-3 2011 In the presence of a P2Y12 antagonist, preincubation of PRP with ADP inhibited aggregation; this effect was abolished by adenosine deaminase. Adenosine Diphosphate 65-68 purinergic receptor P2Y12 Homo sapiens 21-26 21106949-7 2011 CONCLUSIONS: ADP inhibits platelet aggregation in the presence of a P2Y12 antagonist through conversion to adenosine. Adenosine Diphosphate 13-16 purinergic receptor P2Y12 Homo sapiens 68-73 21297950-2 2011 The voltage dependent anion channel type 1 (VDAC1) is a component of the mitochondrial permeability transition pore, regulates mitochondrial ATP/ADP exchange suggesting that its over-expression could be associated with energy dependent processes including increased proliferation and invasiveness. Adenosine Diphosphate 145-148 voltage dependent anion channel 1 Homo sapiens 44-49 21118684-4 2011 Pharmacological nitric oxide synthase (NOS) inhibition protracted the duration of thromboembolic responses to ADP (adenosine diphosphate) and enhanced in vivo platelet aggregation following activation of the coagulation cascade. Adenosine Diphosphate 110-113 nitric oxide synthase 1, neuronal Mus musculus 16-37 21118684-4 2011 Pharmacological nitric oxide synthase (NOS) inhibition protracted the duration of thromboembolic responses to ADP (adenosine diphosphate) and enhanced in vivo platelet aggregation following activation of the coagulation cascade. Adenosine Diphosphate 115-136 nitric oxide synthase 1, neuronal Mus musculus 16-37 21467700-3 2011 METHODS: We measured the ability of 20 microM ADP to aggregate platelets using the VerifyNow P2Y12 Assay. Adenosine Diphosphate 46-49 purinergic receptor P2Y12 Homo sapiens 93-98 27872485-7 2016 DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively. Adenosine Diphosphate 60-63 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 22245547-5 2012 NSF-Ns splay out perpendicular to the ADP-bound hexamer and twist upwards upon ATP binding, producing a more compact structure. Adenosine Diphosphate 38-41 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 0-3 27751850-5 2016 We present a detailed picture of interactions between BECa and NADH, including bound water molecules located near the C1"-N glycosidic bond of NADH and the catalytically important ADP-ribosylating turn-turn (ARTT) loop. Adenosine Diphosphate 180-183 becA Clostridium perfringens 54-58 27522492-2 2016 GPI compete with a wider use of ADP inhibitors and novel anticoagulant drugs although GPI use has greatly narrowed. Adenosine Diphosphate 32-35 glucose-6-phosphate isomerase Homo sapiens 0-3 27686608-7 2016 The ADP inhibited glioma cell viability, invasion and migration, and treatment with the synthesized ADP led to downregulation of p-Akt and MMP-9 and inhibited MMP-9 translation. Adenosine Diphosphate 100-103 matrix metallopeptidase 9 Mus musculus 139-144 27686608-7 2016 The ADP inhibited glioma cell viability, invasion and migration, and treatment with the synthesized ADP led to downregulation of p-Akt and MMP-9 and inhibited MMP-9 translation. Adenosine Diphosphate 100-103 matrix metallopeptidase 9 Mus musculus 159-164 27686608-9 2016 Our findings demonstrate that treatment with an ADP can suppress glioma cell migration and invasion via the PI3K/Akt/MMP-9 signaling pathway and provide a new platform for the development of drugs for treating glioma. Adenosine Diphosphate 48-51 matrix metallopeptidase 9 Mus musculus 117-122 27440879-3 2016 The human TARG1/C6orf130, MacroD1, and MacroD2 proteins can reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity of their macro domains. Adenosine Diphosphate 68-71 mono-ADP ribosylhydrolase 1 Homo sapiens 26-33 27440879-3 2016 The human TARG1/C6orf130, MacroD1, and MacroD2 proteins can reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity of their macro domains. Adenosine Diphosphate 98-101 mono-ADP ribosylhydrolase 1 Homo sapiens 26-33 27369815-4 2016 CGRP increased ATP and ADP levels in meninges and trigeminal cultures and reduced adenosine concentration in trigeminal cells. Adenosine Diphosphate 23-26 calcitonin-related polypeptide alpha Rattus norvegicus 0-4 27528227-5 2016 Muscle contents of ADP and AMP were significantly increased, which was associated with enhanced mitochondrial oxidative phosphorylation and up-regulated expression of fatty acid oxidation enzymes and uncoupling proteins, UCP2 and UCP3 in the skeletal muscle. Adenosine Diphosphate 19-22 uncoupling protein 3 (mitochondrial, proton carrier) Mus musculus 230-234 27480079-5 2016 Adenosine diphosphate (ADP) was used to stimulate the P2Y1/P2Y12 pathway of platelet activation to mimic the in vivo thrombogenic pathway. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 59-64 27480079-5 2016 Adenosine diphosphate (ADP) was used to stimulate the P2Y1/P2Y12 pathway of platelet activation to mimic the in vivo thrombogenic pathway. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 59-64 27480079-6 2016 Platelet aggregation studies utilised both ADP and collagen as exogenous platelet agonists to target both P2Y1/P2Y12 and GPVI pathways of thrombus formation. Adenosine Diphosphate 43-46 purinergic receptor P2Y12 Homo sapiens 111-116 27141100-2 2016 Increases in AMP:ATP and ADP:ATP ratios, signifying energy deficit, promote allosteric activation and net Thr172 phosphorylation mediated by LKB1, so that the LKB1-AMPK pathway acts as an energy sensor. Adenosine Diphosphate 25-28 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 164-168 26876526-10 2016 We observed a decrease in both ATP/ADP and phosphocreatine levels, which were prevented following exposure to insulin or IGF-1. Adenosine Diphosphate 35-38 insulin-like growth factor 1 Mus musculus 121-126 26952923-1 2016 Succinate-CoA ligase, ADP-forming, beta subunit (SUCLA2)-related mitochondrial DNA depletion syndrome is caused by mutations affecting the ADP-using isoform of the beta subunit in succinyl-CoA synthase, which is involved in the Krebs cycle. Adenosine Diphosphate 22-25 succinate-CoA ligase ADP-forming subunit beta Homo sapiens 49-55 27256882-5 2016 Depletion or inhibition of PARP-1 or mutation of the ADP-ribosylation sites on NELF-E promotes Pol II pausing, providing a clear functional link between PARP-1, ADP-ribosylation, and NELF. Adenosine Diphosphate 53-56 NMDA receptor synaptonuclear signaling and neuronal migration factor Homo sapiens 79-83 27256882-5 2016 Depletion or inhibition of PARP-1 or mutation of the ADP-ribosylation sites on NELF-E promotes Pol II pausing, providing a clear functional link between PARP-1, ADP-ribosylation, and NELF. Adenosine Diphosphate 161-164 NMDA receptor synaptonuclear signaling and neuronal migration factor Homo sapiens 79-83 27155231-4 2016 However, Sml1 cooperatively binds to the ES complex in the dGTP/ADP form, whereas with ATP/CDP, Sml1 binds weakly and noncooperatively. Adenosine Diphosphate 64-67 ribonucleotide reductase inhibiting protein SML1 Saccharomyces cerevisiae S288C 9-13 27534113-2 2016 CD39/ATP-diphosphohydrolase is an integral membrane glycoprotein metabolizing ATP and ADP to AMP; in concert with CD73/ecto-5"-nucleotidase, it contributes to extracellular adenosine accumulation. Adenosine Diphosphate 86-89 5' nucleotidase, ecto Rattus norvegicus 114-118 27534113-2 2016 CD39/ATP-diphosphohydrolase is an integral membrane glycoprotein metabolizing ATP and ADP to AMP; in concert with CD73/ecto-5"-nucleotidase, it contributes to extracellular adenosine accumulation. Adenosine Diphosphate 86-89 5' nucleotidase, ecto Rattus norvegicus 119-139 27159677-4 2016 Cellular glycolysis, including cellular glucose uptake, lactate, ATP/ADP and NAD+/NADH ratios, are also inhibited by miR-186. Adenosine Diphosphate 69-72 microRNA 186 Homo sapiens 117-124 26976643-6 2016 We also show that the acetylation of histone H2AX at Lys5 by TIP60, but not the phosphorylation of H2AX, is required for the ADP-ribosylation activity of PARP-1 and its dynamic binding to damaged chromatin. Adenosine Diphosphate 125-128 H2A.X variant histone Homo sapiens 45-49 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 12-15 cytochrome c oxidase subunit 4I1 Homo sapiens 71-79 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 12-15 cytochrome c oxidase subunit 8A Homo sapiens 71-74 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 12-15 cytochrome c oxidase subunit 8A Homo sapiens 108-111 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 24-27 cytochrome c oxidase subunit 4I1 Homo sapiens 71-79 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 24-27 cytochrome c oxidase subunit 8A Homo sapiens 71-74 22729864-9 2012 At high ATP/ADP ratios, ADP is exchanged for ATP at the matrix side of COX IV-1 leading to an inhibition of COX activity, thus enabling COX to sense the energy level and to adjust ATP synthesis to energy demand. Adenosine Diphosphate 24-27 cytochrome c oxidase subunit 8A Homo sapiens 108-111 26950455-14 2016 Upon treatment with Pravastatin reduced platelet LOX-1 expression induced by ADP. Adenosine Diphosphate 77-80 oxidized low density lipoprotein receptor 1 Homo sapiens 49-54 26808867-3 2016 OBJECTIVES: Since ADP mediates its effects via three purinergic receptors P2Y1, P2X1 and P2Y12, their surface expression and function were investigated in washed platelets and, for comparison, in platelet-rich-plasma (PRP) at different time points for up to 2 hours after preparation. Adenosine Diphosphate 18-21 purinergic receptor P2Y12 Homo sapiens 89-94 22933065-3 2012 The mitochondrial transmembrane potential ( psi (m)) reflects the energy stored in the electrochemical gradient across the inner mitochondrial membrane which, in turn, is used by F(0)F(1)-ATPase to convert ADP to ATP during oxidative phosphorylation. Adenosine Diphosphate 206-209 ATP synthase F1 subunit epsilon Homo sapiens 179-194 27812974-3 2016 AMPK complexes are regulated by changes in cellular AMP:ATP or ADP:ATP ratios and by a number of neutraceuticals and some of the widely-used diabetes medications such as metformin and thiazolinonediones. Adenosine Diphosphate 63-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22035359-1 2012 Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. Adenosine Diphosphate 387-408 platelet and endothelial cell adhesion molecule 1 Homo sapiens 0-45 22035359-1 2012 Platelet endothelial cell adhesion molecule-1 (PECAM-1), an immunoreceptor tyrosine-based inhibitory motif containing receptor, plays diverse and apparently contradictory roles in regulating the response of platelets to stimuli; inhibiting platelet response to immunoreceptor tyrosine-based activation motif and G protein-coupled receptor signalling following stimulation with collagen, adenosine diphosphate, and thrombin, as well as enhancing integrin outside-in signalling. Adenosine Diphosphate 387-408 platelet and endothelial cell adhesion molecule 1 Homo sapiens 47-54 26662400-4 2015 CD62p and PAC-1 expression was lower in the ALL group than in the normal group after ADP activation (P < 0.05); PAC-1 expression was lower and higher in the ALL-CR1 group than in normal and ALL groups, respectively (P < 0.05). Adenosine Diphosphate 85-88 dual specificity phosphatase 2 Homo sapiens 10-15 22746349-1 2012 P2Y12 is an important G protein-coupled receptor that is involved in ADP-induced platelet aggregation, which is essential for normal haemostasis. Adenosine Diphosphate 69-72 purinergic receptor P2Y12 Homo sapiens 0-5 26391841-0 2015 Modulation and pre-amplification of PAR1 signaling by ADP acting via the P2Y12 receptor during platelet subpopulation formation. Adenosine Diphosphate 54-57 purinergic receptor P2Y12 Homo sapiens 73-78 26391841-4 2015 However, ADP acting through the P2Y12 receptor was shown to increase the PS-exposing (PS+) platelets fraction produced by thrombin or thrombin-plus-collagen via an unknown mechanism. Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 32-37 23028292-6 2012 Here, we investigated whether interactions with the ATP analog AMP-PNP and ADP can shift the conformational ensemble of Csk in solution using a combination of small angle x-ray scattering and molecular dynamics simulations. Adenosine Diphosphate 75-78 C-terminal Src kinase Homo sapiens 120-123 26391841-8 2015 ADP stimulation of P2Y12 led to cAMP decrease that, in turn, caused changes in phospholipase C phosphorylation by protein kinase A, increase in cytoplasmic calcium level and, consequently, PS+ platelet formation. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 19-24 26018728-6 2015 The increased rate of ADP hydrolysis, measured by ecto-nucleotidases activity, plays a pivotal role in the regulation of cartilage formation and resorption. Adenosine Diphosphate 22-25 tripartite motif containing 33 Homo sapiens 50-54 22829870-5 2012 Through shRNA-mediated silencing we show that the recently-identified mitochondrial Ca(2+) uniporter, MCU, is required for depolarisation-induced mitochondrial Ca(2+) increases, and for a sustained increase in cytosolic ATP/ADP ratio. Adenosine Diphosphate 224-227 mitochondrial calcium uniporter Mus musculus 102-105 22701565-10 2012 Finally, the identification of karyopherin-ss1 as a target of ARTD15-mediated ADP-ribosylation, hints at a novel regulatory mechanism of karyopherin-ss1 functions. Adenosine Diphosphate 78-81 poly(ADP-ribose) polymerase family member 16 Homo sapiens 62-68 21998208-1 2011 Extracellular adenosine (ADO), generated from ATP or ADP through the concerted action of the ectoenzymes CD39 and CD73, elicits autocrine and paracrine effects mediated by type 1 purinergic receptors. Adenosine Diphosphate 53-56 5'-nucleotidase ecto Homo sapiens 114-118 21998208-5 2011 CD39(+)/CD73(+) CLL cells generate ADO from ADP in a time- and concentration-dependent manner. Adenosine Diphosphate 44-47 5'-nucleotidase ecto Homo sapiens 8-12 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 189-210 5'-nucleotidase ecto Homo sapiens 122-142 21855562-2 2011 Measurements were made of the rate of ATP appearance outside mitochondria, due to externally added ADP, as an increase of NADPH absorbance which occurs when ATP is produced in the presence of glucose, hexokinase and glucose-6-phosphate dehydrogenase. Adenosine Diphosphate 99-102 glucose-6-phosphate dehydrogenase Rattus norvegicus 216-249 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 189-210 5'-nucleotidase ecto Homo sapiens 143-147 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 212-215 5'-nucleotidase ecto Homo sapiens 122-142 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 212-215 5'-nucleotidase ecto Homo sapiens 143-147 21989490-18 2011 Hsp104 is a 102 kDa protein with a pI of -5.3, which hexamerizes in the presence of ADP or ATP, or at high protein concentrations in the absence of nucleotide. Adenosine Diphosphate 84-87 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 0-6 26431833-10 2015 In addition, Capan-1 cells express counteracting adenylate kinase (AK1) and nucleoside diphosphate kinase (NDPK) enzymes (NME1, 2), which contribute to metabolism and regeneration of extracellular ATP and other nucleotides (ADP, uridine diphosphate (UDP) and uridine triphosphate (UTP)). Adenosine Diphosphate 224-227 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 122-129 25755009-0 2015 Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen gamma-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocytopenia Rat Model. Adenosine Diphosphate 33-54 fibrinogen gamma chain Rattus norvegicus 92-114 21341337-6 2011 Pretreatment with PLG (5.0 mg/kg) increased the APTT and decreased the ADP-induced platelet Agg(max). Adenosine Diphosphate 71-74 plasminogen Homo sapiens 18-21 25755009-1 2015 Adenosine diphosphate (ADP)-encapsulated liposomes coated with a fibrinogen gamma-chain dodecapeptide [H12 (dodecapeptide ((400) HHLGGAKQAGDV(411) ))-(ADP)-liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (PEG). Adenosine Diphosphate 0-21 fibrinogen gamma chain Rattus norvegicus 65-87 25755009-1 2015 Adenosine diphosphate (ADP)-encapsulated liposomes coated with a fibrinogen gamma-chain dodecapeptide [H12 (dodecapeptide ((400) HHLGGAKQAGDV(411) ))-(ADP)-liposome] is a synthetic platelet substitute, in which the surface is covered with polyethylene glycol (PEG). Adenosine Diphosphate 23-26 fibrinogen gamma chain Rattus norvegicus 65-87 26190692-2 2015 MATERIAL AND METHODS: In a cohort of acute coronary syndrome male patients (n=101), we evaluated the time-course of HPR by ADP (platelet aggregation by 10muM ADP>=70%) and arachidonic acid (platelet aggregation by 1mmol arachidonic acid>=20%) measuring platelet function in the acute phase (T0), at 6months (T1) and 1year (T2). Adenosine Diphosphate 123-126 haptoglobin-related protein Homo sapiens 116-119 21782450-4 2011 We review recent findings showing that AMPK is activated by ADP as well as AMP, and discuss the mechanism by which binding of these nucleotides prevent its dephosphorylation and inactivation. Adenosine Diphosphate 60-63 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 26190692-2 2015 MATERIAL AND METHODS: In a cohort of acute coronary syndrome male patients (n=101), we evaluated the time-course of HPR by ADP (platelet aggregation by 10muM ADP>=70%) and arachidonic acid (platelet aggregation by 1mmol arachidonic acid>=20%) measuring platelet function in the acute phase (T0), at 6months (T1) and 1year (T2). Adenosine Diphosphate 158-161 haptoglobin-related protein Homo sapiens 116-119 21873978-4 2011 Further, microtubule ends fully activate the ATPase by accelerating the exchange of ADP for ATP. Adenosine Diphosphate 84-87 dynein axonemal heavy chain 8 Homo sapiens 45-51 26190692-4 2015 Patients with persistent HPR by ADP were more frequently with higher values of BMI. Adenosine Diphosphate 32-35 haptoglobin-related protein Homo sapiens 25-28 26190692-7 2015 Immature platelet fraction was the only variable significantly associated with late HPR by ADP at multivariate analysis (OR=1.6 (1.08-2.3), p=0.016). Adenosine Diphosphate 91-94 haptoglobin-related protein Homo sapiens 84-87 26270350-3 2015 AK2 regulates the homeostasis of mitochondrial adenine nucleotides (ADP, ATP and AMP) by catalyzing the transfer of high-energy phosphate. Adenosine Diphosphate 68-71 adenylate kinase 2 Homo sapiens 0-3 21565849-5 2011 Both EST and ADP induced a higher percentage increase in platelet receptor expression in Group 1, compared with Group 2, with the most significant difference being shown for the response to the combined stimuli (e.g. MPA, 23.1+-12 vs. 5.63+-8%, P<0.001; platelet PAC-1, 57.7+-47 vs. 13.2+-7%, P<0.001). Adenosine Diphosphate 13-16 dual specificity phosphatase 2 Homo sapiens 266-271 26249166-6 2015 However, our results show that increased endogenous levels of ATP and ADP, but not AMP, directly increase the p50 value of hemoglobin. Adenosine Diphosphate 70-73 dynactin 2 Mus musculus 110-113 21769098-4 2011 AMPK is activated by a fall in ATP (concomitant with a rise in ADP and AMP), which leads to the activation of catabolic pathways and the inhibition of anabolic pathways. Adenosine Diphosphate 63-66 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 21769098-5 2011 Here we review the role of AMPK as an energy sensor and consider the recent finding that ADP, as well as AMP, causes activation of mammalian AMPK. Adenosine Diphosphate 89-92 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 141-145 21769098-6 2011 We also review recent progress in structural studies on phosphorylated AMPK that provides a mechanism for the regulation of AMPK in which AMP and ADP protect it against dephosphorylation. Adenosine Diphosphate 146-149 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 71-75 21769098-6 2011 We also review recent progress in structural studies on phosphorylated AMPK that provides a mechanism for the regulation of AMPK in which AMP and ADP protect it against dephosphorylation. Adenosine Diphosphate 146-149 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 124-128 26321267-5 2015 Nucleotides (predominantly ATP or ADP) that could be released from different cells via controlled specific of unspecific mechanisms constitute a major source of substrate for adenosine production via CD73. Adenosine Diphosphate 34-37 5'-nucleotidase ecto Homo sapiens 200-204 21729334-7 2011 Substitution of a single oxygen atom in the terminal beta-phosphate group of a potent cofactor ADP by sulfur results in ADPbetaS, a cofactor that binds to Ire1 as well as to ADP but does not activate RNase. Adenosine Diphosphate 95-98 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 155-159 21729334-7 2011 Substitution of a single oxygen atom in the terminal beta-phosphate group of a potent cofactor ADP by sulfur results in ADPbetaS, a cofactor that binds to Ire1 as well as to ADP but does not activate RNase. Adenosine Diphosphate 120-123 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 155-159 21729334-8 2011 RNase activity can be rescued by thiophilic metal ions such as Mn2+ and Cd2+, revealing a functional metal ion-phosphate interaction which controls the conformation and RNase activity of the Ire1 ADP complex. Adenosine Diphosphate 196-199 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 191-195 21489985-2 2011 We show here that the pan-PKC inhibitor Ro31-8220 can be used to dissect these events following platelet activation by ADP. Adenosine Diphosphate 119-122 protein kinase C beta Homo sapiens 26-29 21489985-6 2011 ADP-induced secretion was potentiated in the presence of an inhibitor of PKCbeta but not in the presence of available inhibitors of other PKC isoforms in human and mouse platelets. Adenosine Diphosphate 0-3 protein kinase C beta Homo sapiens 73-80 21489985-6 2011 ADP-induced secretion was potentiated in the presence of an inhibitor of PKCbeta but not in the presence of available inhibitors of other PKC isoforms in human and mouse platelets. Adenosine Diphosphate 0-3 protein kinase C beta Homo sapiens 73-76 21489985-7 2011 ADP-induced secretion was also potentiated in mouse platelets deficient in PKCepsilon but not PKC. Adenosine Diphosphate 0-3 protein kinase C, epsilon Mus musculus 75-85 21489985-7 2011 ADP-induced secretion was also potentiated in mouse platelets deficient in PKCepsilon but not PKC. Adenosine Diphosphate 0-3 protein kinase C beta Homo sapiens 75-78 21489985-9 2011 This provides a molecular explanation for the inability of ADP to induce secretion in plasma in the presence of physiological Ca(2+) concentrations, and it reveals a novel role for PKC in inhibiting platelet activation by ADP in vivo. Adenosine Diphosphate 222-225 protein kinase C beta Homo sapiens 181-184 25999342-5 2015 MBP-U94 is also able to hydrolyze adenosine triphosphate (ATP) to ADP, providing the energy for further catalytic activities. Adenosine Diphosphate 66-69 myelin basic protein Homo sapiens 0-3 21447599-1 2011 The expanded CAG repeat that causes striatal cell vulnerability in Huntington"s disease (HD) encodes a polyglutamine tract in full-length huntingtin that is correlated with cellular [ATP] and [ATP/ADP]. Adenosine Diphosphate 197-200 huntingtin Homo sapiens 138-148 25778901-9 2015 In addition, under glucose deprivation, the changes in mitochondrial membrane potential, ADP/ATP ratio, and mitochondrial DNA content were significantly restored in SESN2-overexpressing cells. Adenosine Diphosphate 89-92 sestrin 2 Homo sapiens 165-170 21532533-14 2011 CONCLUSIONS: Compared with the VASP assay, ADP-induced platelet aggregation shows a greater ability to detect a decrease in platelet aggregation after P2Y12 antagonists. Adenosine Diphosphate 43-46 purinergic receptor P2Y12 Homo sapiens 151-156 24814349-5 2015 Nine missense ABCC8 mutations were subjected to in vitro expression studies testing traffic efficiency and responses of mutant channels to activation by MgADP and diazoxide. Adenosine Diphosphate 153-158 ATP binding cassette subfamily C member 8 Homo sapiens 14-19 21572491-2 2011 The interaction of ADP with its platelet receptor P2Y12 plays a crucial role in platelet activation and thrombogenesis. Adenosine Diphosphate 19-22 purinergic receptor P2Y12 Homo sapiens 50-55 21224467-6 2011 HES1-induced PARP1 activation leads to self-ADP ribosylation of PARP1, consumption of nicotinamide adenine dinucleotide(+), diminished adenosine triphosphate levels, and translocation of apoptosis-inducing factor from mitochondria to the nucleus, resulting in apoptosis in B-ALL but not T-cell ALL. Adenosine Diphosphate 44-47 hes family bHLH transcription factor 1 Homo sapiens 0-4 25926814-0 2015 Neonatal Diabetes and Congenital Hyperinsulinism Caused by Mutations in ABCC8/SUR1 are Associated with Altered and Opposite Affinities for ATP and ADP. Adenosine Diphosphate 147-150 ATP binding cassette subfamily C member 8 Homo sapiens 72-77 21317875-3 2011 We have determined the crystal structure of the cytoplasmic portion of dephosphorylated human Ire1alpha bound to ADP, revealing the "phosphoryl-transfer" competent dimeric face-to-face complex, which precedes and is distinct from the back-to-back RNase "active" conformation described for yeast Ire1. Adenosine Diphosphate 113-116 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 94-103 21317875-3 2011 We have determined the crystal structure of the cytoplasmic portion of dephosphorylated human Ire1alpha bound to ADP, revealing the "phosphoryl-transfer" competent dimeric face-to-face complex, which precedes and is distinct from the back-to-back RNase "active" conformation described for yeast Ire1. Adenosine Diphosphate 113-116 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 94-98 25926814-0 2015 Neonatal Diabetes and Congenital Hyperinsulinism Caused by Mutations in ABCC8/SUR1 are Associated with Altered and Opposite Affinities for ATP and ADP. Adenosine Diphosphate 147-150 ATP binding cassette subfamily C member 8 Homo sapiens 78-82 25653283-4 2015 Trends in the thermostability of yeast ADP/ATP carrier AAC2 and ovine uncoupling protein UCP1 allow optimal conditions for stability in detergents to be established but also provide mechanistic insights into the interactions of lipids, substrates, and inhibitors with these proteins. Adenosine Diphosphate 39-42 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 55-59 21392598-3 2011 Increased bleeding with dual antiplatelet therapy can be attributed to blockade of the thromboxane A(2) (by aspirin) and adenosine diphosphate (by P2Y(12) antagonist) platelet activation pathways that are essential to hemostasis. Adenosine Diphosphate 121-142 purinergic receptor P2Y12 Homo sapiens 147-154 25821842-4 2015 In response to ADP, the endogenous ligand of P2Y12, M2 microglia have increased ligand-mediated calcium responses, which are blocked by selective P2Y12 antagonism. Adenosine Diphosphate 15-18 purinergic receptor P2Y12 Homo sapiens 45-50 21343394-5 2011 The bound cyclin D1 decreases the supply of ADP, ATP, and metabolites, thereby reducing energy production. Adenosine Diphosphate 44-47 cyclin D1 Homo sapiens 10-19 25821842-4 2015 In response to ADP, the endogenous ligand of P2Y12, M2 microglia have increased ligand-mediated calcium responses, which are blocked by selective P2Y12 antagonism. Adenosine Diphosphate 15-18 purinergic receptor P2Y12 Homo sapiens 146-151 21136013-1 2011 We have recently shown that ADP-induced activation of protein kinase C (PKC) requires the co-stimulation of both P2Y1 and P2Y12 receptors. Adenosine Diphosphate 28-31 purinergic receptor P2Y12 Homo sapiens 122-127 21136013-2 2011 In this work, we show that inhibition of ADP-mediated phosphorylation of pleckstrin, the main PKC substrate, caused by antagonists of the P2Y12 receptor can be reversed by stimulation of the alpha2-adrenergic receptor by epinephrine. Adenosine Diphosphate 41-44 purinergic receptor P2Y12 Homo sapiens 138-143 25785436-3 2015 The SPL/RGS/SHP-1 complex is present in resting platelets, dissociating when thrombin or TxA2, but not ADP or collagen, activate SHP-1 and release RGS10 and RGS18 to dampen signaling. Adenosine Diphosphate 103-106 sphingosine-1-phosphate lyase 1 Homo sapiens 4-7 25581794-3 2015 Here we report structures of ATP- and ADP-bound NSF, and the NSF/SNAP/SNARE (20S) supercomplex determined by single-particle electron cryomicroscopy at near-atomic to sub-nanometre resolution without imposing symmetry. Adenosine Diphosphate 38-41 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 48-51 25581794-4 2015 Large, potentially force-generating, conformational differences exist between ATP- and ADP-bound NSF. Adenosine Diphosphate 87-90 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 97-100 26632148-6 2015 ADP activates human platelets by stimulating both P2Y1R and P2Y12R, which act sequentially and in concert to achieve complete platelet aggregation. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 60-66 25293769-3 2014 Poly(adenosine 5"-diphosphate [ADP]-ribose)-polymerase (PARP)-14 belongs to a family of intracellular proteins that generate ADP-ribose posttranslational adducts. Adenosine Diphosphate 31-34 poly (ADP-ribose) polymerase family, member 14 Mus musculus 56-64 25297833-3 2014 High on-treatment platelet reactivity to ADP (HPR) during clopidogrel therapy is an independent risk factor for ischemic event occurrences in post-percutaneous coronary intervention (post-PCI) patients. Adenosine Diphosphate 41-44 haptoglobin-related protein Homo sapiens 46-49 25297833-7 2014 Evidence available from studies evaluating aspirin resistance and high and low on-treatment platelet reactivity to ADP during P2Y12 receptor blocker therapy was collected from a selective literature search. Adenosine Diphosphate 115-118 purinergic receptor P2Y12 Homo sapiens 126-131 24824502-2 2014 A recently reported crystal structure has illuminated the complex regulatory mechanisms by which AMP and ADP cause activation of AMPK, involving phosphorylation by the upstream kinase LKB1. Adenosine Diphosphate 105-108 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 129-133 25080434-5 2014 Extracellular nucleotides and adenosine were shown to be rapidly metabolized on tumor cell surfaces via sequential ecto-5"-nucleotidase (CD73/NT5E) and adenosine deaminase reactions with subsequent cellular uptake of nucleoside metabolites and their intracellular interconversion into ADP/ATP. Adenosine Diphosphate 285-288 5'-nucleotidase ecto Homo sapiens 137-141 25199965-9 2014 BMI, concentrations of hemoglobin, glycated hemoglobin, and BNP, hematocrit, adherence to medication, and patient s age were found to be independent predictors of high on-treatment ADP-induced platelet aggregation only at a single follow-up visit. Adenosine Diphosphate 181-184 natriuretic peptide B Homo sapiens 60-63 24865146-4 2014 Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation. Adenosine Diphosphate 116-119 mono-ADP ribosylhydrolase 1 Homo sapiens 45-52 24865146-4 2014 Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation. Adenosine Diphosphate 170-173 mono-ADP ribosylhydrolase 1 Homo sapiens 45-52 25037531-2 2014 Oral antiplatelet agents for secondary prevention include the cyclo-oxygenase-1 inhibitor aspirin, and the ADP dependent P2Y12 inhibitors clopidogrel, prasugrel and ticagrelor. Adenosine Diphosphate 107-110 purinergic receptor P2Y12 Homo sapiens 121-126 25186167-0 2014 P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia. Adenosine Diphosphate 75-78 purinergic receptor P2Y13 Homo sapiens 0-5 21216445-0 2011 Identification of P2Y12 single-nucleotide polymorphisms and their influences on the variation in ADP-induced platelet aggregation. Adenosine Diphosphate 97-100 purinergic receptor P2Y12 Homo sapiens 18-23 21216445-5 2011 The effects of genetic variation in the P2Y12 gene on the extent of ADP-induced platelet aggregation were studied in healthy Korean men (n=40). Adenosine Diphosphate 68-71 purinergic receptor P2Y12 Homo sapiens 40-45 21216445-8 2011 Genetic analysis of the P2Y12 SNPs and haplotypes revealed a statistically significant association between P2Y12 haplotype, denoted H3, and an increase in the ADP-induced platelet aggregation response relative to that for the reference haplotype H1 (P=0.01). Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 24-29 25186167-4 2014 The action of ADP on [Ca(2+)]i was significantly blocked by MRS2211 (a selective P2Y13 receptor antagonist), but was unaffected by MRS2179 (a selective P2Y1 receptor antagonist) or MRS2395 (a selective P2Y12 receptor antagonist), which suggest that P2Y13 receptor may be responsible for ADP-evoked Ca(2+) mobilization in cultured microglia. Adenosine Diphosphate 14-17 purinergic receptor P2Y13 Homo sapiens 81-86 21216445-8 2011 Genetic analysis of the P2Y12 SNPs and haplotypes revealed a statistically significant association between P2Y12 haplotype, denoted H3, and an increase in the ADP-induced platelet aggregation response relative to that for the reference haplotype H1 (P=0.01). Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 107-112 25186167-4 2014 The action of ADP on [Ca(2+)]i was significantly blocked by MRS2211 (a selective P2Y13 receptor antagonist), but was unaffected by MRS2179 (a selective P2Y1 receptor antagonist) or MRS2395 (a selective P2Y12 receptor antagonist), which suggest that P2Y13 receptor may be responsible for ADP-evoked Ca(2+) mobilization in cultured microglia. Adenosine Diphosphate 14-17 purinergic receptor P2Y13 Homo sapiens 249-254 25186167-10 2014 These observations suggest that the activation of P2Y13 receptor might be involved in the effect of ADP on [Ca(2+)]i in cultured dorsal spinal cord microglia. Adenosine Diphosphate 100-103 purinergic receptor P2Y13 Homo sapiens 50-55 24709060-7 2014 Moreover, the findings that ADP also protects ANT-1 from the toxic action of the two Alzheimer"s disease peptides, i.e. Abeta1-42 and NH2htau, which are known to be produced in apoptotic cerebellar neurons, further corroborate the molecular mechanism of neuroprotection by ADP, herein proposed. Adenosine Diphosphate 28-31 solute carrier family 25 member 4 Rattus norvegicus 46-51 21148312-10 2011 These data provide further understanding of the mechanisms that regulate endogenous ADP-ribosylation of the Gbeta subunit, and they demonstrate a novel role for Arf6 in hormone regulation of Gbeta subunit mono-ADP-ribosylation. Adenosine Diphosphate 84-87 succinate-CoA ligase GDP-forming subunit beta Homo sapiens 108-113 24861054-6 2014 Blockade of ActRIIB signaling downregulates porin, a crucial ADP/ATP shuttle between cytosol and mitochondrial matrix leading to a consecutive deficiency of oxidative phosphorylation as measured by in vivo Phosphorus Magnetic Resonance Spectroscopy ((31)P-MRS). Adenosine Diphosphate 61-64 activin receptor IIB Mus musculus 12-19 20966167-0 2011 The platelet P2Y12 receptor for adenosine diphosphate: congenital and drug-induced defects. Adenosine Diphosphate 32-53 purinergic receptor P2Y12 Homo sapiens 13-18 20966167-1 2011 P2Y12, the G(i)-coupled platelet receptor for adenosine diphosphate (ADP), plays a central role in platelet function. Adenosine Diphosphate 46-67 purinergic receptor P2Y12 Homo sapiens 0-5 20966167-1 2011 P2Y12, the G(i)-coupled platelet receptor for adenosine diphosphate (ADP), plays a central role in platelet function. Adenosine Diphosphate 69-72 purinergic receptor P2Y12 Homo sapiens 0-5 24816772-8 2014 Moreover, our data indicates that ApoBDS-1-induced platelet activation is partially dependent of positive feedback from ADP on P2Y1 and P2Y12, and TxA2. Adenosine Diphosphate 120-123 purinergic receptor P2Y12 Homo sapiens 136-141 20966167-3 2011 Defects of P2Y12 should be suspected when ADP, even at high concentrations (>= 10 muM), is unable to induce full, irreversible platelet aggregation. Adenosine Diphosphate 42-45 purinergic receptor P2Y12 Homo sapiens 11-16 24984036-6 2014 Located in the C-terminal end of the RS domain, this nonconsensus region up-regulates rate-limiting ADP release through the nucleotide release factor, a structural module in SRPK1 composed of two noncontiguous sequence elements outside the kinase core domain. Adenosine Diphosphate 100-103 SRSF protein kinase 1 Homo sapiens 174-179 21059804-9 2011 The EP2 agonist butaprost inhibited ADP-induced secondary phase slopes (IC(50), 40 +- 20 nM). Adenosine Diphosphate 36-39 prostaglandin E receptor 2 Homo sapiens 4-7 20978083-2 2011 The u-ATP9 transgene driven by A9 and APETALA3 promoters induce mitochondrial dysfunction revealed by a decrease in both oxygen uptake and adenine nucleotides (ATP, ADP) levels without changes in the ATP/ADP ratio. Adenosine Diphosphate 165-168 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 38-46 20813187-0 2010 P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells. Adenosine Diphosphate 36-39 purinergic receptor P2Y13 Rattus norvegicus 0-7 20813187-6 2010 ADP-induced intracellular calcium mobilization was blocked by phospholipase C inhibitor U73122 and by P2Y(1) receptor-selective antagonist MRS2500, but not by pertussis toxin (PTX), suggesting a mechanism mediated by the G(q)-coupled P2Y(1) receptor, but not P2Y(13) (G(i)-coupled) or P2X receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Rattus norvegicus 259-266 20813187-7 2010 ADP-induced Hex release was blocked by PTX and a selective P2Y(13) receptor antagonist MRS2211, but not by MRS2500 or P2Y(1) receptor-specific siRNA, suggesting a G(i)-coupled P2Y(13) receptor-related mechanism. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Rattus norvegicus 59-66 20813187-7 2010 ADP-induced Hex release was blocked by PTX and a selective P2Y(13) receptor antagonist MRS2211, but not by MRS2500 or P2Y(1) receptor-specific siRNA, suggesting a G(i)-coupled P2Y(13) receptor-related mechanism. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Rattus norvegicus 176-183 20813187-9 2010 Thus, we demonstrated that ADP-mediated intracellular calcium mobilization and Hex release in RBL-2H3 cells are via P2Y(1) and P2Y(13) receptors, respectively. Adenosine Diphosphate 27-30 purinergic receptor P2Y13 Rattus norvegicus 127-134 25163307-4 2014 New generation of P2Y12 ADP antagonists including prasugrel and ticagrelor are available, but only in patients with acute coronary syndrome. Adenosine Diphosphate 24-27 purinergic receptor P2Y12 Homo sapiens 18-23 24583089-3 2014 The current understanding of AMPK structure and regulation, however, has propelled a paradigm shift in which many researchers now consider ADP to be an additional regulatory nucleotide of AMPK. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 29-33 24583089-3 2014 The current understanding of AMPK structure and regulation, however, has propelled a paradigm shift in which many researchers now consider ADP to be an additional regulatory nucleotide of AMPK. Adenosine Diphosphate 139-142 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 188-192 24914234-3 2014 Informatics analyses reported here show that RNA granule proteins enriched for low complexity regions, which aid self-assembly, are preferentially modified by poly(ADP-ribose), indicating how poly(ADP-ribose) could direct cellular organization. Adenosine Diphosphate 164-167 activation induced cytidine deaminase Homo sapiens 109-112 24671606-9 2014 In conclusion, VN-P2Y12 overestimates the functional effects of clopidogrel in some individuals, possibly because it utilises PGE1 in addition to ADP. Adenosine Diphosphate 146-149 purinergic receptor P2Y12 Homo sapiens 18-23 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 13-34 CREB regulated transcription coactivator 1 Mus musculus 89-95 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 13-34 CREB regulated transcription coactivator 1 Mus musculus 241-247 23913658-6 2014 In vitro assay of alphaIIbbeta3 and phosphorylation of ERK1/2 were performed in ADP-treated platelet. Adenosine Diphosphate 80-83 mitogen activated protein kinase 3 Rattus norvegicus 55-61 24705415-9 2014 Synergistic signaling via P2Y12 and thromboxane receptor through secreted ADP and TxA2, respectively, were important for echicetin bead triggered platelet activation. Adenosine Diphosphate 74-77 purinergic receptor P2Y12 Homo sapiens 26-31 25247182-2 2014 Adenosine diphosphate (ADP) activates gpiibiiia and P2Y12, causing platelet aggregation and thrombus stabilization during blood loss. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 52-57 21103408-4 2010 This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores. Adenosine Diphosphate 21-24 glutamate receptor, ionotropic, kainate 1 Mus musculus 76-82 20977463-2 2010 Concentrations of nucleotides such as ADP, the physiological agonist at platelet P2Y1 and P2Y12 receptors, are regulated by vascular ectonucleotidases, mainly nucleoside triphosphate diphosphohydrolase (NTPDase)1 and ecto-5"-nucleotidase. Adenosine Diphosphate 38-41 purinergic receptor P2Y12 Homo sapiens 90-95 20977463-2 2010 Concentrations of nucleotides such as ADP, the physiological agonist at platelet P2Y1 and P2Y12 receptors, are regulated by vascular ectonucleotidases, mainly nucleoside triphosphate diphosphohydrolase (NTPDase)1 and ecto-5"-nucleotidase. Adenosine Diphosphate 38-41 5'-nucleotidase ecto Homo sapiens 217-237 25247182-2 2014 Adenosine diphosphate (ADP) activates gpiibiiia and P2Y12, causing platelet aggregation and thrombus stabilization during blood loss. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 52-57 24713587-4 2014 Treatment of cells with exogenous ADP stimulates cellular autophagy and also blocks HL release. Adenosine Diphosphate 34-37 lipase C, hepatic type Homo sapiens 84-86 24713587-7 2014 ADP acts through the G-protein coupled receptor, P2Y13, to stimulate autophagy. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 49-54 24713587-10 2014 To evaluate the effect of extracellular ADP on the processing of HL, we expressed a V5-epitope tag-labeled HL (HL-V5) and then measured secretion, uptake and degradation. Adenosine Diphosphate 40-43 lipase C, hepatic type Homo sapiens 65-67 24849284-2 2014 Sulfonylureas, insulin secretagogues used to treat type II diabetes, inhibit K(ATP) channel activity primarily by abolishing the stimulatory effect of MgADP endowed by SUR1. Adenosine Diphosphate 151-156 ATP binding cassette subfamily C member 8 Homo sapiens 168-172 23885646-1 2014 Clopidogrel is a thienopyridine that selectively and irreversibly inhibits the ADP purinergic receptor P2Y12 and the subsequent ADP-mediated platelet activation. Adenosine Diphosphate 79-82 purinergic receptor P2Y12 Homo sapiens 103-108 24272707-2 2014 In addition to the accepted roles for the P2 X4,7 and P2 Y12 receptors activated by adenosine triphosphate (ATP) and adenosine diphosphate, respectively, recent evidence suggests a role for the adenosine A2A receptor in microglial cytoskeletal rearrangements. Adenosine Diphosphate 117-138 purinergic receptor P2Y12 Homo sapiens 42-60 24260208-12 2013 In addition, both of a specific inhibitor of FGF receptors and anti-FGF2 antibody significantly counteracted the increasing effect of CM on ADP proliferation. Adenosine Diphosphate 140-143 fibroblast growth factor 2 Rattus norvegicus 45-48 20977287-5 2010 On the other hand, thienopyridines suppress the platelet aggregation adenosine diphosphate (ADP) pathway by inhibiting the platelet P2Y12 subtype of the ADP receptor. Adenosine Diphosphate 69-90 purinergic receptor P2Y12 Homo sapiens 132-137 20977287-5 2010 On the other hand, thienopyridines suppress the platelet aggregation adenosine diphosphate (ADP) pathway by inhibiting the platelet P2Y12 subtype of the ADP receptor. Adenosine Diphosphate 92-95 purinergic receptor P2Y12 Homo sapiens 132-137 24260208-12 2013 In addition, both of a specific inhibitor of FGF receptors and anti-FGF2 antibody significantly counteracted the increasing effect of CM on ADP proliferation. Adenosine Diphosphate 140-143 fibroblast growth factor 2 Rattus norvegicus 68-72 20921368-5 2010 Our results suggest a previously undescribed solution to the classic problem of how the ADP and diphosphoglycerate binding sites of PGK come together to make ATP: Rather than undergoing a hinge motion, the ADP and substrate sites are already located in proximity under crowded conditions that mimic the in vivo conditions under which the enzyme actually operates. Adenosine Diphosphate 88-91 phosphoglycerate kinase Saccharomyces cerevisiae S288C 132-135 20921368-5 2010 Our results suggest a previously undescribed solution to the classic problem of how the ADP and diphosphoglycerate binding sites of PGK come together to make ATP: Rather than undergoing a hinge motion, the ADP and substrate sites are already located in proximity under crowded conditions that mimic the in vivo conditions under which the enzyme actually operates. Adenosine Diphosphate 206-209 phosphoglycerate kinase Saccharomyces cerevisiae S288C 132-135 20816663-5 2010 These results are attributable to the delay in the attachment of the motor"s leading head (ADP P(i) state) to actin, induced by the competitive binding of drebrin-E to actin, whereas the rate of ADP release from the trailing head (the rate-limiting step in the ATPase cycle of myosin V) is unaffected. Adenosine Diphosphate 91-94 drebrin 1 Homo sapiens 155-164 20816663-5 2010 These results are attributable to the delay in the attachment of the motor"s leading head (ADP P(i) state) to actin, induced by the competitive binding of drebrin-E to actin, whereas the rate of ADP release from the trailing head (the rate-limiting step in the ATPase cycle of myosin V) is unaffected. Adenosine Diphosphate 195-198 drebrin 1 Homo sapiens 155-164 24260208-14 2013 These suggest that AMI may increase ADP proliferation indirectly via PCA and that FGF2 may a potential candidate to mediate such an indirect effect of AMI on ADP proliferation via astrocytes. Adenosine Diphosphate 158-161 fibroblast growth factor 2 Rattus norvegicus 82-86 20177818-1 2010 The interaction of ADP with its platelet receptor P2Y12 plays a crucial role in platelet activation and thrombogenesis. Adenosine Diphosphate 19-22 purinergic receptor P2Y12 Homo sapiens 50-55 24244663-3 2013 In this study we confirm that thrombin, thromboxane A2, or ADP stimulate the interaction of RGS18 and 14-3-3 by increasing the phosphorylation of S49. Adenosine Diphosphate 59-62 regulator of G protein signaling 18 Homo sapiens 92-97 20876358-2 2010 K(ATP) channels carrying this mutation (Kir6.2-G334D/SUR1 channels) were activated by MgATP and MgADP with an EC(50) of 112 and 8 microM, respectively. Adenosine Diphosphate 96-101 ATP binding cassette subfamily C member 8 Homo sapiens 53-57 20876358-4 2010 The EC(50) for activation of Kir6.2-G334D/SUR1 currents by MgADP was lower than that for MgATP, and the time course of activation was faster. Adenosine Diphosphate 59-64 ATP binding cassette subfamily C member 8 Homo sapiens 42-46 20876358-8 2010 By comparing our results with those obtained for wild-type K(ATP) channels, we conclude that the MgADP sensitivity of the wild-type K(ATP) channel can be described quantitatively by a combination of inhibition at Kir6.2 (measured for wild-type channels in the absence of Mg(2+)) and activation via SUR1 (determined for Kir6.2-G334D/SUR1 channels). Adenosine Diphosphate 97-102 ATP binding cassette subfamily C member 8 Homo sapiens 298-302 24071464-1 2013 BACKGROUND: Platelets express two ADP receptors namely P2Y1 and P2Y12 that regulate ADP and other agonists-induced platelet aggregation. Adenosine Diphosphate 34-37 purinergic receptor P2Y12 Homo sapiens 64-69 20876358-8 2010 By comparing our results with those obtained for wild-type K(ATP) channels, we conclude that the MgADP sensitivity of the wild-type K(ATP) channel can be described quantitatively by a combination of inhibition at Kir6.2 (measured for wild-type channels in the absence of Mg(2+)) and activation via SUR1 (determined for Kir6.2-G334D/SUR1 channels). Adenosine Diphosphate 97-102 ATP binding cassette subfamily C member 8 Homo sapiens 332-336 20525793-4 2010 Multiple explicit water molecular dynamics simulations of the H4 tail peptide into the catalytic cleft of PARP1 indicate that two stable intermolecular salt bridges hold the peptide in an orientation that allows K16 ADP-ribosylation. Adenosine Diphosphate 216-219 keratin 16 Homo sapiens 212-215 24022487-4 2013 Here we present evidence that, for the GroEL-GroES chaperonin system, the non-native substrate protein enters the folding cycle on the trans ring of the double-ring GroEL-ATP-GroES complex rather than the ADP-bound complex. Adenosine Diphosphate 205-208 heat shock protein family E (Hsp10) member 1 Homo sapiens 45-50 20457661-0 2010 Polynucleotide phosphorylase and mitochondrial ATP synthase mediate reduction of arsenate to the more toxic arsenite by forming arsenylated analogues of ADP and ATP. Adenosine Diphosphate 153-156 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 0-28 20457661-7 2010 PNPase can also form AMP-AsV from ADP and AsV (termed arsenolysis of ADP). Adenosine Diphosphate 34-37 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 0-6 20457661-7 2010 PNPase can also form AMP-AsV from ADP and AsV (termed arsenolysis of ADP). Adenosine Diphosphate 69-72 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 0-6 23884248-2 2013 Different aspirin dosing regimens have been suggested to impact outcomes when used in combination with adenosine diphosphate (ADP) P2Y12 receptor antagonists. Adenosine Diphosphate 103-124 purinergic receptor P2Y12 Homo sapiens 131-136 20645041-9 2010 Bupivacaine induced a significant decrease in the citrate synthase activity in psoas (r(2) = 0.74; P < 0.001) and gracilis muscle (r(2) = 0.52; P < 0.001), and there was a significant decrease in the adenosine diphosphate-stimulated oxygen consumption using glutamate or succinate as substrates in both muscles (P < 0.001). Adenosine Diphosphate 206-227 citrate synthase Rattus norvegicus 50-66 23884248-2 2013 Different aspirin dosing regimens have been suggested to impact outcomes when used in combination with adenosine diphosphate (ADP) P2Y12 receptor antagonists. Adenosine Diphosphate 126-129 purinergic receptor P2Y12 Homo sapiens 131-136 20664906-5 2010 The reference test was P2Y12 receptor occupancy, measured by binding of 33P-2MeS-ADP to platelets. Adenosine Diphosphate 81-84 purinergic receptor P2Y12 Homo sapiens 23-28 24396733-4 2013 To identify drugs that modulate AMPK activity independent of the canonical ATP-binding pocket found throughout the kinome, we designed a robust fluorescence-based high throughput screening assay biased toward the identification of molecules that bind the regulatory region of AMPK through displacement of MANT-ADP, a fluorescent ADP analog. Adenosine Diphosphate 310-313 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 276-280 20529842-1 2010 We have developed a stable analog for the ADP-insensitive phosphoenzyme intermediate with two occluded Ca(2+) at the transport sites (E2PCa(2)) of sarcoplasmic reticulum Ca(2+)-ATPase. Adenosine Diphosphate 42-45 dynein axonemal heavy chain 8 Homo sapiens 177-183 23747347-2 2013 AMPK is an alphabetagamma heterotrimer controlled by allosteric regulation by AMP, ADP and ATP, auto-inhibitory features and phosphorylation, with the threonine-172 phosphorylation on the catalytic alpha-subunit by LKB1, CaMKKbeta or Tak1 being essential for its fully activation. Adenosine Diphosphate 83-86 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 20167273-3 2010 Reagentless biosensors, binding proteins that are labeled with a fluorophore, target products of the helicase reaction, namely ADP, inorganic phosphate or single-stranded DNA, and can be used to measure rates of product formation with little interference to the system. Adenosine Diphosphate 127-130 helicase for meiosis 1 Homo sapiens 101-109 23849096-0 2013 Effect of P2Y1 and P2Y12 genetic polymorphisms on the ADP-induced platelet aggregation in a Korean population. Adenosine Diphosphate 54-57 purinergic receptor P2Y12 Homo sapiens 19-24 23849096-1 2013 BACKGROUND: P2Y1 and P2Y12 receptors are expressed in platelet membranes and are involved in ADP-induced platelet aggregation. Adenosine Diphosphate 93-96 purinergic receptor P2Y12 Homo sapiens 21-26 23849096-2 2013 Genetic polymorphisms of P2Y1 and P2Y12 play a major role in the variation of ADP-induced platelet aggregation and in response in antiplatelet therapy. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 34-39 23849096-7 2013 However, the P2Y12 c.52G>T polymorphism caused a substantial difference in ADP-induced maximal platelet aggregation (62.75% for c.52GG, 66.27% for c.52GT, and 80.60% for c.52TT; P=0.0092). Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 13-18 23765277-4 2013 The adenosine diphosphate-mediated interaction between the central nucleotide-binding domain (NBD) and the winged-helix domain (WHD) was critical for stabilizing the closed conformation of NLRC4. Adenosine Diphosphate 4-25 NLR family, CARD domain containing 4 Mus musculus 189-194 23765277-7 2013 Disruption of ADP-mediated NBD-WHD or NBD-HD2/NBD-LRR interactions resulted in constitutive activation of NLRC4. Adenosine Diphosphate 14-17 NLR family, CARD domain containing 4 Mus musculus 106-111 23601906-1 2013 The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. Adenosine Diphosphate 197-200 5'-nucleotidase ecto Homo sapiens 37-41 23467297-7 2013 Mucin granules isolated from VNUT short hairpin RNA-expressing cells exhibited a marked reduction of ATP, ADP, AMP, and UTP levels within granules. Adenosine Diphosphate 106-109 LOC100508689 Homo sapiens 0-5 23751441-4 2013 Although the pattern of defective ADP-induced platelet aggregation in MPN suggests an abnormality in the P2Y12 pathway, no previous studies have specifically evaluated P2Y12 function in MPN or the relationship between P2Y12 function and the JAK2V617F mutation. Adenosine Diphosphate 34-37 purinergic receptor P2Y12 Homo sapiens 105-110 23594617-1 2013 OBJECTIVE: The novel P2Y12 antagonist ticagrelor inhibits adenosine diphosphate (ADP)-induced platelet aggregation more potently than clopidogrel and reduces the incidence of myocardial infarction and total death in patients with an acute coronary syndrome (ACS). Adenosine Diphosphate 58-79 purinergic receptor P2Y12 Homo sapiens 21-26 23594617-1 2013 OBJECTIVE: The novel P2Y12 antagonist ticagrelor inhibits adenosine diphosphate (ADP)-induced platelet aggregation more potently than clopidogrel and reduces the incidence of myocardial infarction and total death in patients with an acute coronary syndrome (ACS). Adenosine Diphosphate 81-84 purinergic receptor P2Y12 Homo sapiens 21-26 23470885-7 2013 ADP-specific assays (ADP-LTA, the VASP index and VerifyNow-P2Y12) differed according to CYP2C19 genotype, with a significant gene-dose effect (PMs>IMs>EMs). Adenosine Diphosphate 0-3 vasodilator stimulated phosphoprotein Homo sapiens 34-38 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 111-114 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 178-182 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 340-343 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 178-182 23093496-7 2013 The potency at P2Y(12) was 2-(methylthio)-ADP > 2-(methylthio)-ATP > ADP > ATP. Adenosine Diphosphate 42-45 purinergic receptor P2Y12 Homo sapiens 15-22 23093496-12 2013 This study showed that, in addition to ADP and ATP, other ATP derivatives are not only ligands of P2Y(12) but also agonists. Adenosine Diphosphate 39-42 purinergic receptor P2Y12 Homo sapiens 98-105 23111421-2 2013 METHODS: We genotyped a functional variant in CES1, G143E, in participants of the Pharmacogenomics of Anti-Platelet Intervention (PAPI) study (n=566) and in 350 patients with coronary heart disease treated with clopidogrel, and carried out an association analysis of bioactive metabolite levels, on-clopidogrel ADP-stimulated platelet aggregation, and cardiovascular outcomes. Adenosine Diphosphate 311-314 carboxylesterase 1 Homo sapiens 46-50 23111421-4 2013 Consistent with these findings, individuals who carried the CES1 143E-allele showed a better clopidogrel response as measured by ADP-stimulated platelet aggregation in both participants of the PAPI study (P=0.003) and clopidogrel-treated coronary heart disease patients (P=0.03). Adenosine Diphosphate 129-132 carboxylesterase 1 Homo sapiens 60-64 22757746-1 2013 The VerifyNow P2Y12 test is a whole-blood, light transmission-based optical detection assay that measures adenosine diphosphate-induced platelet aggregation in a cartridge containing fibrinogen-coated beads. Adenosine Diphosphate 106-127 purinergic receptor P2Y12 Homo sapiens 14-19 23472176-6 2013 In contrast, selective P2Y12 agonists ADP and 2-MeS-ADP induced specific calcium flux in cells expressing P2Y12+ Galpha16. Adenosine Diphosphate 38-41 purinergic receptor P2Y12 Homo sapiens 23-28 20026007-1 2010 Silencing of the ATP5E gene in HEK293 cells resulted in downregulation of the activity and content of the mitochondrial ATP synthase complex and of ADP-stimulated respiration to approximately 40% of the control. Adenosine Diphosphate 148-151 ATP synthase F1 subunit epsilon Homo sapiens 17-22 23472176-6 2013 In contrast, selective P2Y12 agonists ADP and 2-MeS-ADP induced specific calcium flux in cells expressing P2Y12+ Galpha16. Adenosine Diphosphate 38-41 purinergic receptor P2Y12 Homo sapiens 106-111 23472176-6 2013 In contrast, selective P2Y12 agonists ADP and 2-MeS-ADP induced specific calcium flux in cells expressing P2Y12+ Galpha16. Adenosine Diphosphate 38-41 G protein subunit alpha 15 Homo sapiens 113-121 23093445-5 2012 Moreover, whereas polymerization of wild-type ParF is accelerated by ATP and inhibited by ADP, filamentation of the mutated proteins is blocked indiscriminately by nucleotides. Adenosine Diphosphate 90-93 RAB, member RAS oncogene family like 6 Homo sapiens 46-50 20392510-3 2010 In addition, we show that the induction of GLP-1 release in enteroendocrine cells by 6alpha-ethyl-23(S)-methyl-cholic acid (EMCA, INT-777), a specific TGR5 agonist, is linked to an increase of the intracellular ATP/ADP ratio and a subsequent rise in intracellular calcium mobilization. Adenosine Diphosphate 215-218 glucagon Mus musculus 43-48 20139097-6 2010 Furthermore, Cdc42-deficient platelets showed enhanced secretion of alpha granules, a higher adenosine diphosphate (ADP)/adenosine triphosphate (ATP) content, increased aggregation at low agonist concentrations, and enhanced aggregate formation on collagen under flow. Adenosine Diphosphate 93-114 cell division cycle 42 Mus musculus 13-18 20139097-6 2010 Furthermore, Cdc42-deficient platelets showed enhanced secretion of alpha granules, a higher adenosine diphosphate (ADP)/adenosine triphosphate (ATP) content, increased aggregation at low agonist concentrations, and enhanced aggregate formation on collagen under flow. Adenosine Diphosphate 116-119 cell division cycle 42 Mus musculus 13-18 20417606-2 2010 We have discovered that the flavonol quercetin activates yeast IRE1"s RNase and potentiates activation by ADP, a natural activating ligand that engages the IRE1 nucleotide-binding cleft. Adenosine Diphosphate 106-109 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 156-160 20417606-3 2010 Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain. Adenosine Diphosphate 72-75 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 52-56 20417606-3 2010 Enzyme kinetics and the structure of a cocrystal of IRE1 complexed with ADP and quercetin reveal engagement by quercetin of an unanticipated ligand-binding pocket at the dimer interface of IRE1"s kinase extension nuclease (KEN) domain. Adenosine Diphosphate 72-75 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 189-193 20210760-2 2010 In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the platelet P2Y12 receptor elicits progressive and sustained platelet aggregation. Adenosine Diphosphate 37-58 purinergic receptor P2Y12 Homo sapiens 96-101 20210760-2 2010 In vivo, activated platelets release adenosine diphosphate (ADP), whose binding to the platelet P2Y12 receptor elicits progressive and sustained platelet aggregation. Adenosine Diphosphate 60-63 purinergic receptor P2Y12 Homo sapiens 96-101 20168331-2 2010 The structure of yeast Prp43p-ADP reveals the homology of DEAH helicases to DNA helicases and the presence of an oligonucleotide-binding motif. Adenosine Diphosphate 30-33 DEAH-box ATP-dependent RNA helicase PRP43 Saccharomyces cerevisiae S288C 23-29 20147598-0 2010 Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. Adenosine Diphosphate 102-105 dynein axonemal heavy chain 8 Homo sapiens 17-23 20147598-7 2010 The authors have evaluated the use of commercial reagents (Transcreener ADP) for the measurement of ATPase activity of both yeast and human Hsp90 (ATP K(m) approximately 500 microM) and human Hsp72 (ATP K(m) ~1 microM). Adenosine Diphosphate 72-75 dynein axonemal heavy chain 8 Homo sapiens 100-106 19945153-5 2010 Ap(4)A inhibited 3 microM ADP-induced: a) platelet aggregation (IC(50) 9.8+/-2.8 microM), b) P2Y(1)-mediated shape change, c) P2Y(1)-mediated increase in platelet cytosolic Ca(2+) (IC(50) 40.8+/-12.3 microM), and d) P2Y(12)-mediated decrease in VASP phosphorylation (IC(50)>250 microM). Adenosine Diphosphate 26-29 vasodilator stimulated phosphoprotein Homo sapiens 245-249 19818001-6 2010 RESULTS: ADP-inducible platelet reactivity increased linearly with age after adjustment for cardiovascular risk factors, type of intervention, medication, C-reactive protein (CRP) and renal function [using LTA 0.36% of maximal aggregation per year, 95% CI 0.08-0.64%, P = 0.013; using the VerifyNow P2Y12 assay 3.2 P2Y12 reaction units (PRU) per year, 95% CI 1.98-4.41 PRU, P < 0.001]. Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 299-304 19818001-6 2010 RESULTS: ADP-inducible platelet reactivity increased linearly with age after adjustment for cardiovascular risk factors, type of intervention, medication, C-reactive protein (CRP) and renal function [using LTA 0.36% of maximal aggregation per year, 95% CI 0.08-0.64%, P = 0.013; using the VerifyNow P2Y12 assay 3.2 P2Y12 reaction units (PRU) per year, 95% CI 1.98-4.41 PRU, P < 0.001]. Adenosine Diphosphate 9-12 purinergic receptor P2Y12 Homo sapiens 315-320 19818001-7 2010 ADP-inducible platelet reactivity was significantly higher in patients aged 75 years or older compared with younger patients (P = 0.003 for LTA and P < 0.001 for the VerifyNow P2Y12 assay). Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 179-184 19818001-8 2010 Further, high on-treatment residual ADP-inducible platelet reactivity was significantly more common among patients aged 75 years or older (P = 0.02 for LTA and P < 0.001 for the VerifyNow P2Y12 assay). Adenosine Diphosphate 36-39 purinergic receptor P2Y12 Homo sapiens 191-196 19350338-2 2010 The spontaneous microaggregates of platelets induced by shear stress were accelerated after the treatment, concomitant with the significant upregulation of p44/p42 mitogen-activated protein (MAP) kinase induced by adenosine diphosphate (ADP). Adenosine Diphosphate 214-235 interferon induced protein 44 Homo sapiens 156-159 19350338-2 2010 The spontaneous microaggregates of platelets induced by shear stress were accelerated after the treatment, concomitant with the significant upregulation of p44/p42 mitogen-activated protein (MAP) kinase induced by adenosine diphosphate (ADP). Adenosine Diphosphate 237-240 interferon induced protein 44 Homo sapiens 156-159 19350338-3 2010 After the cessation of raloxifene, the spontaneous microaggregates of platelets and the acceleration of ADP-induced p44/p42 MAP kinase phosphorylation was diminished. Adenosine Diphosphate 104-107 interferon induced protein 44 Homo sapiens 116-119 19350338-8 2010 RESULTS: The platelet aggregation induced by ADP was little changed; however, low doses (0.3 and 1 microM) of ADP significantly induced the phosphorylation of p44/p42 MAP kinase in the platelets obtained at 12 weeks. Adenosine Diphosphate 110-113 interferon induced protein 44 Homo sapiens 159-162 19350338-11 2010 At 12 weeks after the cessation, the phosphorylation of p44/p42 MAP kinase induced by low doses of ADP was no more observed. Adenosine Diphosphate 99-102 interferon induced protein 44 Homo sapiens 56-59 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 glycoprotein 6 (platelet) Mus musculus 13-17 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Mus musculus 137-145 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Mus musculus 196-204 19700402-7 2009 In addition, GPVI-induced Akt phosphorylation in the presence of ADP antagonists was completely inhibited by PI3K inhibitor LY294002 and PI3Kbeta inhibitor TGX-221 indicating an essential role of PI3Kbeta in Akt activation directly downstream of GPVI. Adenosine Diphosphate 65-68 glycoprotein 6 (platelet) Mus musculus 246-250 19833728-11 2009 This signaling network locks PDK2 in the inactive closed conformation, which is in equilibrium with the active open conformation without DCA and ADP. Adenosine Diphosphate 145-148 pyruvate dehydrogenase kinase 2 Homo sapiens 29-33 19595797-3 2009 The dependence on concentration of nucleotide association with the ATPase was examined using ADP and ATP-induced quenching of the fluorescence of ATPase labeled with Cy3-maleimide (Cy3-ATPase) or Alexa Fluor 546 carboxylic acid, succinimidyl ester (AF-ATPase). Adenosine Diphosphate 93-96 dynein axonemal heavy chain 8 Homo sapiens 67-73 19631364-6 2009 RESULTS: There was a correlation between the ADP-receptor inhibition as measured by VASP-assay and VerifyNowP2Y(12) (r = -0.29, p<0.05), and between VASP-assay and the expression of P-selectin (r = 0.29, p<0.05) as measured by flow cytometry when platelets were stimulated with 5 microM ADP. Adenosine Diphosphate 45-48 vasodilator stimulated phosphoprotein Homo sapiens 84-88 19631364-6 2009 RESULTS: There was a correlation between the ADP-receptor inhibition as measured by VASP-assay and VerifyNowP2Y(12) (r = -0.29, p<0.05), and between VASP-assay and the expression of P-selectin (r = 0.29, p<0.05) as measured by flow cytometry when platelets were stimulated with 5 microM ADP. Adenosine Diphosphate 45-48 vasodilator stimulated phosphoprotein Homo sapiens 152-156 23074217-7 2012 Transport studies in yeast mitochondria showed that TbMCP5 has biochemical properties and ADP/ATP exchange kinetics similar to those of Anc2p, the prototypical ADP/ATP carrier of S. cerevisiae. Adenosine Diphosphate 160-163 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 136-141 19841671-4 2009 We present the crystal structure of the AAA-domain of human paraplegin bound to ADP at 2.2 A. Adenosine Diphosphate 80-83 SPG7 matrix AAA peptidase subunit, paraplegin Homo sapiens 60-70 20031628-9 2009 The size of this effect per haplotype allele was approximately 5% aggregation in the ADP-induced light-transmittance aggregometry (P<0.05) and 11 P2Y12 reaction units in the VerifyNow P2Y12 assay (P<0.05). Adenosine Diphosphate 85-88 purinergic receptor P2Y12 Homo sapiens 187-192 19738041-4 2009 Here, we report the structures of native hMTHFS, a binary complex of hMTHFS with ADP, hMTHFS bound with the N5-iminium phosphate reaction intermediate, and an enzyme-product complex of hMTHFS. Adenosine Diphosphate 81-84 methenyltetrahydrofolate synthetase Homo sapiens 69-75 19738041-4 2009 Here, we report the structures of native hMTHFS, a binary complex of hMTHFS with ADP, hMTHFS bound with the N5-iminium phosphate reaction intermediate, and an enzyme-product complex of hMTHFS. Adenosine Diphosphate 81-84 methenyltetrahydrofolate synthetase Homo sapiens 69-75 19738041-4 2009 Here, we report the structures of native hMTHFS, a binary complex of hMTHFS with ADP, hMTHFS bound with the N5-iminium phosphate reaction intermediate, and an enzyme-product complex of hMTHFS. Adenosine Diphosphate 81-84 methenyltetrahydrofolate synthetase Homo sapiens 69-75 23009844-7 2012 Here, we present the first, to our knowledge, thermodynamic characterization of oligomeric states of cotton beta-Rca complexed with Mg ADP. Adenosine Diphosphate 132-138 ribulose bisphosphate carboxylase/oxygenase activase 2, chloroplastic Gossypium hirsutum 113-116 19476973-0 2009 Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy. Adenosine Diphosphate 70-73 purinergic receptor P2Y12 Homo sapiens 95-100 23009844-11 2012 We propose that under some conditions, ADP-bound Rca self-associates by forming spiral arrangements that grow along the helical axis. Adenosine Diphosphate 39-42 ribulose bisphosphate carboxylase/oxygenase activase 2, chloroplastic Gossypium hirsutum 49-52 22730437-6 2012 We show that isolated cow lung COX containing COX4i2 is about twice as active (88 and 102% increased activity in the presence of allosteric activator ADP and inhibitor ATP, respectively) as liver COX, which lacks COX4i2. Adenosine Diphosphate 150-153 cytochrome c oxidase subunit 4I2 Bos taurus 46-52 19363223-6 2009 Assessment of distinct three-dimensional functional states of PAN in the presence of adenosine 5"-O-(thiotriphosphate) and ADP and in the absence of nucleotides outlined a possible mechanism linking nucleotide binding and hydrolysis to substrate recognition, unfolding, and translocation. Adenosine Diphosphate 123-126 adenosine deaminase 2 Homo sapiens 62-65 19666527-1 2009 Nicotinamide phosphoribosyltransferase (NAMPT) is highly evolved to capture nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD(+)) pool during ADP-ribosylation and transferase reactions. Adenosine Diphosphate 168-171 nicotinamide phosphoribosyltransferase Homo sapiens 40-45 19435740-3 2009 Selected sites prospectively enrolled TRITON-TIMI 38 patients to evaluate adenosine diphosphate (ADP)-attenuated phosphorylation of platelet vasodilator-stimulated phosphoprotein (VASP) (n = 125 patients) and, in a subset (n = 31 patients), ADP-stimulated platelet aggregation. Adenosine Diphosphate 74-95 vasodilator stimulated phosphoprotein Homo sapiens 141-178 19435740-3 2009 Selected sites prospectively enrolled TRITON-TIMI 38 patients to evaluate adenosine diphosphate (ADP)-attenuated phosphorylation of platelet vasodilator-stimulated phosphoprotein (VASP) (n = 125 patients) and, in a subset (n = 31 patients), ADP-stimulated platelet aggregation. Adenosine Diphosphate 74-95 vasodilator stimulated phosphoprotein Homo sapiens 180-184 19435740-3 2009 Selected sites prospectively enrolled TRITON-TIMI 38 patients to evaluate adenosine diphosphate (ADP)-attenuated phosphorylation of platelet vasodilator-stimulated phosphoprotein (VASP) (n = 125 patients) and, in a subset (n = 31 patients), ADP-stimulated platelet aggregation. Adenosine Diphosphate 97-100 vasodilator stimulated phosphoprotein Homo sapiens 141-178 19435740-3 2009 Selected sites prospectively enrolled TRITON-TIMI 38 patients to evaluate adenosine diphosphate (ADP)-attenuated phosphorylation of platelet vasodilator-stimulated phosphoprotein (VASP) (n = 125 patients) and, in a subset (n = 31 patients), ADP-stimulated platelet aggregation. Adenosine Diphosphate 97-100 vasodilator stimulated phosphoprotein Homo sapiens 180-184 19433572-4 2009 Pharmacological studies showed that ADP was elicited by mGluR5 stimulation via G-protein-dependent activation of phospholipase C and elevation of intracellular Ca(2+) levels. Adenosine Diphosphate 36-39 glutamate receptor, ionotropic, kainate 1 Mus musculus 56-62 19433572-8 2009 Collectively, these data suggest that mGluR5 activation upregulates I(NaP) in MSNs of the NAc, thereby inducing an ADP that results in enhanced MSN excitability. Adenosine Diphosphate 115-118 glutamate receptor, ionotropic, kainate 1 Mus musculus 38-44 19218546-4 2009 Platelet aggregates produced ex vivo with ADP or collagen and fibrinogen are destroyed by the C-terminal ADAMTS-18 fragment. Adenosine Diphosphate 42-45 ADAM metallopeptidase with thrombospondin type 1 motif 18 Homo sapiens 105-114 19130895-0 2009 Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase. Adenosine Diphosphate 71-74 adenylate kinase 4 Homo sapiens 23-41 19003877-1 2009 A strategically placed tryptophan in position of Arg416 was used as an optical probe to monitor adenosine triphosphate and adenosine-diphosphate binding to subunit B of the A(1)A(O) adenosine triphosphate (ATP) synthase from Methanosarcina mazei Go1. Adenosine Diphosphate 123-144 hypothetical protein Methanosarcina mazei Go1 182-219 19286657-11 2009 In addition, pretreatment of platelets with eta-RACK antagonistic peptides, a specific inhibitor of nPKCeta, inhibited ADP-induced thromboxane generation. Adenosine Diphosphate 119-122 endothelin receptor type A Homo sapiens 44-47 19377479-2 2009 The subunits MSH2 and MSH3 can bind either ADP or ATP with similar affinities. Adenosine Diphosphate 43-46 mutS homolog 2 Homo sapiens 13-17 19377479-2 2009 The subunits MSH2 and MSH3 can bind either ADP or ATP with similar affinities. Adenosine Diphosphate 43-46 mutS homolog 3 Homo sapiens 22-26 19377479-3 2009 Upon binding to a DNA loop, however, MSH2-MSH3 adopts a single "nucleotide signature", in which the MSH2 subunit is occupied by an ADP molecule and the MSH3 subunit is empty. Adenosine Diphosphate 131-134 mutS homolog 2 Homo sapiens 37-41 19377479-3 2009 Upon binding to a DNA loop, however, MSH2-MSH3 adopts a single "nucleotide signature", in which the MSH2 subunit is occupied by an ADP molecule and the MSH3 subunit is empty. Adenosine Diphosphate 131-134 mutS homolog 3 Homo sapiens 42-46 19377479-3 2009 Upon binding to a DNA loop, however, MSH2-MSH3 adopts a single "nucleotide signature", in which the MSH2 subunit is occupied by an ADP molecule and the MSH3 subunit is empty. Adenosine Diphosphate 131-134 mutS homolog 2 Homo sapiens 100-104 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 66-69 mutS homolog 3 Homo sapiens 45-49 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 66-69 mutS homolog 2 Homo sapiens 90-94 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 66-69 mutS homolog 2 Homo sapiens 141-145 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 66-69 mutS homolog 3 Homo sapiens 146-150 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 151-154 mutS homolog 3 Homo sapiens 45-49 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 18704487-8 2009 Rac1 ( -/- ) platelets displayed defective thrombus formation on collagen under flow conditions which could be fully restored by co-infusion of ADP and the TxA(2) analog U46619, indicating that impaired GPVI-, but not G-protein signaling, was responsible for the observed defect. Adenosine Diphosphate 144-147 Rac family small GTPase 1 Mus musculus 0-4 19235053-7 2009 U46619 induced aggregation was suppressed by the addition of ADP scavenger (CP/CPK) with no significant change on ATP measured and the effect of CP/CPK could not be reversed by aspirin. Adenosine Diphosphate 61-64 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 79-82 19236702-8 2009 ADP-induced inhibition of VASP-phosphorylation was unaffected by hypothermia both in the presence and absence of clopidogrel. Adenosine Diphosphate 0-3 vasodilator stimulated phosphoprotein Homo sapiens 26-30 19036069-12 2009 TRPV1-dependent 5-HT release also contributed to ADP- and thrombin-evoked Ca(2+) entry and release. Adenosine Diphosphate 49-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18715873-2 2008 They are constituted by two proteins: a pore-forming K(+) channel subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cassette (ABC) transporter that confers MgADP stimulation to the channel. Adenosine Diphosphate 200-205 ATP binding cassette subfamily C member 8 Homo sapiens 108-129 18715873-2 2008 They are constituted by two proteins: a pore-forming K(+) channel subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cassette (ABC) transporter that confers MgADP stimulation to the channel. Adenosine Diphosphate 200-205 ATP binding cassette subfamily C member 8 Homo sapiens 131-134 18715873-3 2008 Channel regulation by MgADP is dependent on nucleotide interaction with the cytoplasmic nucleotide binding folds (NBF1 and NBF2) of the SUR subunit. Adenosine Diphosphate 22-27 ATP binding cassette subfamily C member 8 Homo sapiens 136-139 18755689-2 2008 We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 222-227 18854029-1 2008 BACKGROUND: Human ART4, carrier of the GPI-(glycosyl-phosphatidylinositol) anchored Dombrock blood group antigens, is an apparently inactive member of the mammalian mono-ADP-ribosyltransferase (ART) family named after the enzymatic transfer of a single ADP-ribose moiety from NAD+ to arginine residues of extracellular target proteins. Adenosine Diphosphate 170-173 ADP-ribosyltransferase 3 (inactive) Homo sapiens 18-21 18658136-5 2008 The 2.0-A crystal structures of the PDK4 dimer with bound ADP reveal an open conformation with a wider active-site cleft, compared with that in the closed conformation epitomized by the PDK2-ADP structure. Adenosine Diphosphate 191-194 pyruvate dehydrogenase kinase 2 Homo sapiens 186-190 22459907-1 2012 INTRODUCTION: Clopidogrel inhibits ADP mediated platelet aggregation through inhibition of the P2Y12 receptor by its active metabolite. Adenosine Diphosphate 35-38 purinergic receptor P2Y12 Homo sapiens 95-100 22852789-6 2012 Using this technique, we confirmed the primacy of continuous signaling by the ADP autocrine loop acting on P2Y12 in the maintenance of thrombus stability. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 107-112 22702974-4 2012 AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Adenosine Diphosphate 87-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 22702974-4 2012 AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Adenosine Diphosphate 87-90 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 129-133 22628078-10 2012 Docking of FPP in a P2Y12 receptor model revealed molecular similarities with ADP and a good fit into the binding pocket for ADP. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 20-25 18703838-5 2008 The cocrystal structure of wild-type zPlk1 KD with ADP documented the hydrolysis of ATP and revealed the phosphorylation site. Adenosine Diphosphate 51-54 polo-like kinase 1 (Drosophila) Danio rerio 37-42 18644642-6 2008 NTPDase and 5"-nucleotidase activities demonstrated a positive correlation between serum glucose levels and ATP and ADP hydrolysis in DM-2 and DM-2/HT patients. Adenosine Diphosphate 116-119 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 134-138 18644642-6 2008 NTPDase and 5"-nucleotidase activities demonstrated a positive correlation between serum glucose levels and ATP and ADP hydrolysis in DM-2 and DM-2/HT patients. Adenosine Diphosphate 116-119 immunoglobulin heavy diversity 1-14 (non-functional) Homo sapiens 143-147 18539602-7 2008 These data suggest that CTCF is involved in the cross-talk between poly(ADP-ribosyl)ation and DNA methylation and underscore the importance of a rapid reversal of PARP activity, as DNA methylation pattern is responsible for an important epigenetic code. Adenosine Diphosphate 71-75 CCCTC-binding factor Mus musculus 24-28 18328759-2 2008 METHODS: We utilized ADP-triggered platelet aggregation assays to test the effects of IGF-I versus IGF-II in complex with IGFBP-2 or IGFBP-3 upon the efficiency of plasmin (a known IGFBP protease) as a pro-aggregatory stimulus. Adenosine Diphosphate 21-24 plasminogen Homo sapiens 164-171 18564178-6 2008 It has been shown that serine racemase is activated by divalent cations like calcium, magnesium and manganese, as well as by nucleotides like ATP, ADP or GTP. Adenosine Diphosphate 147-150 serine racemase Homo sapiens 23-38 18562646-1 2008 AAC2 is one of three paralogs encoding mitochondrial ADP/ATP carriers in the yeast Saccharomyces cerevisiae, and because it is required for respiratory growth it has been the most extensively studied. Adenosine Diphosphate 53-56 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 0-4 18562646-5 2008 On the basis of the growth rate differences of yeast expressing different chimeras, the C1 and M2 loops of the ADP/ATP carriers contain divergent residues that are responsible for the difference(s) between Aac1 and Aac2. Adenosine Diphosphate 111-114 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 215-219 18555782-4 2008 In the complex, the NBD of Sse1p is ATP bound, and together with the 3HBD it embraces the NBD of Hsp70, inducing opening and the release of bound ADP from Hsp70. Adenosine Diphosphate 146-149 adenyl-nucleotide exchange factor SSE1 Saccharomyces cerevisiae S288C 27-32 22628078-10 2012 Docking of FPP in a P2Y12 receptor model revealed molecular similarities with ADP and a good fit into the binding pocket for ADP. Adenosine Diphosphate 125-128 purinergic receptor P2Y12 Homo sapiens 20-25 22234696-6 2012 Serine 216 phosphorylation is able to block 14-3-3 binding to RGS18 even in the presence of thrombin, thromboxane A2, or ADP. Adenosine Diphosphate 121-124 regulator of G protein signaling 18 Homo sapiens 62-67 18436807-6 2008 Platelets from SR-BI KO mice exhibited in vitro a blunted aggregation response to the agonist ADP but a normal response to PAR4. Adenosine Diphosphate 94-97 scavenger receptor class B, member 1 Mus musculus 15-20 18183622-2 2008 We previously reported that ATP/ADP promotes microglial chemotaxis via the Gi/o-coupled P2Y12 receptor; however, the intracellular signaling underlying P2Y12-receptor-mediated microglial chemotaxis is not fully understood. Adenosine Diphosphate 32-35 purinergic receptor P2Y12 Homo sapiens 88-93 18183622-2 2008 We previously reported that ATP/ADP promotes microglial chemotaxis via the Gi/o-coupled P2Y12 receptor; however, the intracellular signaling underlying P2Y12-receptor-mediated microglial chemotaxis is not fully understood. Adenosine Diphosphate 32-35 purinergic receptor P2Y12 Homo sapiens 152-157 18183622-6 2008 ADP stimulation induced Akt phosphorylation in microglia, and the phosphorylation was inhibited by a P2Y12 receptor antagonist, AR-C69931MX. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 101-106 18443290-9 2008 We used this mutant for the detection of adenosine diphosphate at the single-molecule level, after equipping the porin with a cyclodextrin molecular adapter, thereby demonstrating its potential for use in stochastic sensing applications. Adenosine Diphosphate 41-62 voltage dependent anion channel 1 Homo sapiens 113-118 18443293-1 2008 A majority of ATP in the brain is formed in the mitochondria through oxidative phosphorylation of ADP with the F(1)F(0)-ATP (ATPase) enzyme. Adenosine Diphosphate 98-101 dynein axonemal heavy chain 8 Homo sapiens 125-131 18299327-2 2008 Two regions of Anc2p from Saccharomyces cerevisiae are specifically photolabeled using a photoactivable ADP derivative; they are the central matrix loop, m2, and the C-terminal end. Adenosine Diphosphate 104-107 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 15-20 22155453-6 2012 A correlation between platelet binding of 9E18 and P-selectin exposure was observed in patients experiencing coronary artery disease, and antagonists of the ADP receptor P2Y12 limited ADP-induced GPVI dimerization. Adenosine Diphosphate 157-160 purinergic receptor P2Y12 Homo sapiens 170-175 18299327-7 2008 We show that the C-terminal region is no further accessible to antibodies when Anc2p binds non-transportable analogues of ADP. Adenosine Diphosphate 122-125 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 79-84 18281290-1 2008 ATP/ADP-sensing (sulfonylurea receptor (SUR)/K(IR)6)(4) K(ATP) channels regulate the excitability of our insulin secreting and other vital cells via the differential MgATP/ADP-dependent stimulatory actions of their tissue-specific ATP-binding cassette regulatory subunits (sulfonylurea receptors), which counterbalance the nearly constant inhibitory action of ATP on the K(+) inwardly rectifying pore. Adenosine Diphosphate 4-7 ATP binding cassette subfamily C member 8 Homo sapiens 40-43 18305207-5 2008 Constitutive tuber-specific apyrase expression did not lead to a reduction of ATP, but rather a decrease in ADP and an increase in AMP levels. Adenosine Diphosphate 108-111 apyrase Solanum tuberosum 28-35 22562119-3 2012 ATP acts on Kir6.2 to stabilize the channel closed state while ADP (coordinated with Mg(2+)) activates channels via the SUR1 domains. Adenosine Diphosphate 63-66 ATP binding cassette subfamily C member 8 Homo sapiens 120-124 18065447-8 2008 Moreover, ADF/cofilin fragmentation while modulating filament length keeps filaments in a high molar ratio of ATP- or ADP-P(i) versus ADP-bound subunits. Adenosine Diphosphate 118-121 destrin, actin depolymerizing factor Homo sapiens 10-13 18065447-8 2008 Moreover, ADF/cofilin fragmentation while modulating filament length keeps filaments in a high molar ratio of ATP- or ADP-P(i) versus ADP-bound subunits. Adenosine Diphosphate 118-121 cofilin 1 Homo sapiens 14-21 18081742-2 2008 We show here that the extended generation time of RAS2(Val19)cells is the result of abrogated ATP/ADP carrier activity of the mitochondria. Adenosine Diphosphate 98-101 Ras family GTPase RAS2 Saccharomyces cerevisiae S288C 50-54 21689688-7 2012 Hydrodynamic analysis of NSF, labeled with (Ni(2+)-NTA)(2)-Cy3, detected conformational differences in NSF, in which the ATP-bound conformation appears more compact than the ADP-bound form. Adenosine Diphosphate 174-177 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 25-28 18557130-5 2008 The analysis suggests that that under physiological conditions a pH decrease accompanied by a free Mg2+ increase tends to counteract an [ADP] increase due to PCr depletion. Adenosine Diphosphate 137-140 mucin 7, secreted Homo sapiens 99-102 21689688-7 2012 Hydrodynamic analysis of NSF, labeled with (Ni(2+)-NTA)(2)-Cy3, detected conformational differences in NSF, in which the ATP-bound conformation appears more compact than the ADP-bound form. Adenosine Diphosphate 174-177 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 103-106 22250198-4 2012 The objective of our study was to investigate the role of some different types of purinergic receptors, P2Y1, P2Y13 and P2X7, which are activated by ADP or ATP. Adenosine Diphosphate 149-152 purinergic receptor P2Y13 Homo sapiens 110-115 23272056-6 2012 The binding affinities of spastin and katanin were nucleotide-sensitive, with the lowest affinities under ADP,, the highest under ATP-gammaS conditions. Adenosine Diphosphate 106-109 spastin Homo sapiens 26-33 18313366-1 2008 Comparison of the amino acid sequence of yeast type 2 ADP/ATP carrier (yAAC2) with that of bovine type 1 AAC (bAAC1) revealed that the N- and C-terminus of yAAC2 are 15- and 6-amino acids longer, respectively, than those of bAAC1. Adenosine Diphosphate 54-57 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 71-76 18313366-1 2008 Comparison of the amino acid sequence of yeast type 2 ADP/ATP carrier (yAAC2) with that of bovine type 1 AAC (bAAC1) revealed that the N- and C-terminus of yAAC2 are 15- and 6-amino acids longer, respectively, than those of bAAC1. Adenosine Diphosphate 54-57 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 156-161 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 94-97 mutS homolog 2 Homo sapiens 18-23 19192628-1 2007 The oxoglutarate carrier (OGC) is a member of the mitochondrial carrier protein superfamily, which includes the ADP/ATP carrier and other functionally characterized members, and exchanges cytosolic malate for 2-oxoglutarate from the mitochondrial matrix. Adenosine Diphosphate 112-115 solute carrier family 25 member 11 Homo sapiens 26-29 19192628-5 2007 We also evaluated the compatibility between the helical structures of our peptides and a homology model of the OGC based on the available X-ray structure of the ATP/ADP carrier. Adenosine Diphosphate 165-168 solute carrier family 25 member 11 Homo sapiens 111-114 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 94-97 mutS homolog 2 Homo sapiens 56-61 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 94-97 mutS homolog 2 Homo sapiens 56-61 18064324-5 2007 There was no spontaneous aggregation in PRP but ADP-induced aggregation was enhanced at 28 degrees C. The P2Y12 antagonist AR-C69931 inhibited all spontaneous aggregation at 28 degrees C and reduced all ADP-induced aggregation responses to small, reversible responses. Adenosine Diphosphate 48-51 purinergic receptor P2Y12 Homo sapiens 106-111 18064324-5 2007 There was no spontaneous aggregation in PRP but ADP-induced aggregation was enhanced at 28 degrees C. The P2Y12 antagonist AR-C69931 inhibited all spontaneous aggregation at 28 degrees C and reduced all ADP-induced aggregation responses to small, reversible responses. Adenosine Diphosphate 203-206 purinergic receptor P2Y12 Homo sapiens 106-111 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 105-118 mutS homolog 2 Homo sapiens 18-23 17764960-1 2007 To develop nonprostanoid prostacyclin receptor agonists with a high degree of metabolic resistance and an extended duration of action, a novel series of diphenylpyrazine derivatives was synthesized and evaluated for their inhibition of ADP-induced human platelet aggregation. Adenosine Diphosphate 236-239 prostaglandin I2 receptor Homo sapiens 25-46 17855752-8 2007 In contrast, rundown and MgADP reactivation of wild-type and Kir6.2-G334D/SUR2A channels, and of Kir6.2-F333I/SUR1 channels, involve a gradual change in P(o). Adenosine Diphosphate 25-30 ATP binding cassette subfamily C member 8 Homo sapiens 110-114 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 105-118 mutS homolog 2 Homo sapiens 56-61 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 105-118 mutS homolog 2 Homo sapiens 56-61 17902708-1 2007 Phosphomevalonate kinase (PMK) catalyzes the cation-dependent reaction of mevalonate 5-phosphate with ATP to form mevalonate 5-diphosphate and ADP, a key step in the mevalonate pathway for isoprenoid/sterol biosynthesis. Adenosine Diphosphate 143-146 phosphomevalonate kinase Homo sapiens 0-24 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Adenosine Diphosphate 40-43 mutS homolog 2 Homo sapiens 57-62 17902708-1 2007 Phosphomevalonate kinase (PMK) catalyzes the cation-dependent reaction of mevalonate 5-phosphate with ATP to form mevalonate 5-diphosphate and ADP, a key step in the mevalonate pathway for isoprenoid/sterol biosynthesis. Adenosine Diphosphate 143-146 phosphomevalonate kinase Homo sapiens 26-29 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Adenosine Diphosphate 40-43 mutS homolog 2 Homo sapiens 146-151 21940635-5 2011 Importantly, addition of low doses of ADP and/or fibrinogen restored aggregation of Rap1b-deficient platelets. Adenosine Diphosphate 38-41 RAP1B, member of RAS oncogene family Homo sapiens 84-89 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 33-54 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 209-213 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 56-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 209-213 17294140-11 2007 Thus, ADP acting on the endothelial P2Y(1) receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 198-201 purinergic receptor P2Y1 Sus scrofa 36-51 21803289-4 2011 Deletion of mIndy in mice (mINDY(-/-) mice) reduces hepatocellular ATP/ADP ratio, activates hepatic AMPK, induces PGC-1alpha, inhibits ACC-2, and reduces SREBP-1c levels. Adenosine Diphosphate 71-74 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Mus musculus 12-17 17673465-4 2007 We demonstrate that p110 beta is primarily responsible for G(i)-dependent phosphatidylinositol 3,4-bisphosphate (PI(3,4)P(2)) production in ADP-stimulated platelets and is linked to the activation of Rap1b and AKT. Adenosine Diphosphate 140-143 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Mus musculus 20-29 17631897-7 2007 Surprisingly, although DDX3X was crystallized in the presence of a large excess of ADP or the slowly hydrolyzable ATP analogue ATPgammaS the contaminant AMP was seen in the structure. Adenosine Diphosphate 83-86 DEAD-box helicase 3 X-linked Homo sapiens 23-28 17631897-8 2007 A fluorescent-based stability assay showed that the thermal stability of DDX3X was increased by the mononucleotide AMP but not by ADP or ATPgammaS, suggesting that DDX3X is stabilized by AMP and elucidating why AMP was found in the nucleotide-binding pocket. Adenosine Diphosphate 130-133 DEAD-box helicase 3 X-linked Homo sapiens 73-78 21803289-4 2011 Deletion of mIndy in mice (mINDY(-/-) mice) reduces hepatocellular ATP/ADP ratio, activates hepatic AMPK, induces PGC-1alpha, inhibits ACC-2, and reduces SREBP-1c levels. Adenosine Diphosphate 71-74 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Mus musculus 27-32 21713327-10 2011 In conclusion, a patient"s intrinsic platelet response to ADP before exposure to thienopyridines contributes to residual platelet reactivity to ADP despite high level P2Y12 blockade with high-dose clopidogrel or even higher level P2Y12 blockade with prasugrel. Adenosine Diphosphate 58-61 purinergic receptor P2Y12 Homo sapiens 167-172 17524547-3 2007 In both cases, the chimeric carrier, Anc2-Cyc1(His6)p, was able to restore growth on a non-fermentable carbon source of a yeast strain devoid of functional ADP/ATP carrier, demonstrating its transport activity. Adenosine Diphosphate 156-159 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 37-41 17524547-3 2007 In both cases, the chimeric carrier, Anc2-Cyc1(His6)p, was able to restore growth on a non-fermentable carbon source of a yeast strain devoid of functional ADP/ATP carrier, demonstrating its transport activity. Adenosine Diphosphate 156-159 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Saccharomyces cerevisiae S288C 47-51 17524547-10 2007 Improved production and purification of Anc2-Cyc1(His6)p-CATR complex opens up new possibilities for the use of this protein in crystallographic approaches to the yeast ADP/ATP carrier. Adenosine Diphosphate 169-172 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 40-44 17524547-10 2007 Improved production and purification of Anc2-Cyc1(His6)p-CATR complex opens up new possibilities for the use of this protein in crystallographic approaches to the yeast ADP/ATP carrier. Adenosine Diphosphate 169-172 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Saccharomyces cerevisiae S288C 50-54 17524547-11 2007 Furthermore, Anc2-Cyc1(His6)p may be an useful molecular tool to investigate in vivo interactions between components of the respiratory chain complexes such as COX and the proteins implicated in ATP biogenesis, such as the ATP/ADP carrier. Adenosine Diphosphate 227-230 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 13-17 17524547-11 2007 Furthermore, Anc2-Cyc1(His6)p may be an useful molecular tool to investigate in vivo interactions between components of the respiratory chain complexes such as COX and the proteins implicated in ATP biogenesis, such as the ATP/ADP carrier. Adenosine Diphosphate 227-230 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Saccharomyces cerevisiae S288C 23-27 21713327-10 2011 In conclusion, a patient"s intrinsic platelet response to ADP before exposure to thienopyridines contributes to residual platelet reactivity to ADP despite high level P2Y12 blockade with high-dose clopidogrel or even higher level P2Y12 blockade with prasugrel. Adenosine Diphosphate 58-61 purinergic receptor P2Y12 Homo sapiens 230-235 21628579-2 2011 alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric effectors that control enzyme activity (A site) and substrate specificity (S site). Adenosine Diphosphate 38-41 norrin cystine knot growth factor NDP Homo sapiens 12-15 17697119-1 2007 Brain serine racemase contains pyridoxal phosphate as a prosthetic group and is known to become activated by divalent cations such as Ca(2+) and Mg(2+), as well as by ATP and ADP. Adenosine Diphosphate 175-178 serine racemase Homo sapiens 6-21 21569335-7 2011 After carotid ferric chloride injury, EMILIN2 was abundantly expressed in the thrombus and inhibition of EMILIN2 increased platelet de-aggregation after ADP-stimulated platelet aggregation. Adenosine Diphosphate 153-156 elastin microfibril interfacer 2 Mus musculus 38-45 16963188-5 2006 MgADP is a product inhibitor for Atm1p with an IC(50) of 0.9 mM. Adenosine Diphosphate 0-5 ATP-binding cassette Fe/S cluster precursor transporter ATM1 Saccharomyces cerevisiae S288C 33-38 16963188-7 2006 A plot of ATPase activity versus concentration of Atm1p exhibits a nonlinear relationship, suggesting an allosteric response and an important role for the transmembrane domain in mediating both ATP hydrolysis and MgADP release. Adenosine Diphosphate 213-218 ATP-binding cassette Fe/S cluster precursor transporter ATM1 Saccharomyces cerevisiae S288C 50-55 16940296-7 2006 The thermosensor effect of the ADP/ATP exchange factor GrpE retards the release of substrate from the cycle at higher temperatures; the fraction of total DnaK in stable (ADP x DnaK) x substrate complexes is 2 times higher at 45 degrees C than at 25 degrees C. Monitoring the cellular situation by DnaJ as nonnative protein sensor and GrpE as thermosensor thus directly adapts the operational mode of the DnaK system to heat shock conditions. Adenosine Diphosphate 31-34 GrpE like 1, mitochondrial Homo sapiens 55-59 16940296-7 2006 The thermosensor effect of the ADP/ATP exchange factor GrpE retards the release of substrate from the cycle at higher temperatures; the fraction of total DnaK in stable (ADP x DnaK) x substrate complexes is 2 times higher at 45 degrees C than at 25 degrees C. Monitoring the cellular situation by DnaJ as nonnative protein sensor and GrpE as thermosensor thus directly adapts the operational mode of the DnaK system to heat shock conditions. Adenosine Diphosphate 31-34 DnaJ heat shock protein family (Hsp40) member C14 Homo sapiens 297-301 16940296-7 2006 The thermosensor effect of the ADP/ATP exchange factor GrpE retards the release of substrate from the cycle at higher temperatures; the fraction of total DnaK in stable (ADP x DnaK) x substrate complexes is 2 times higher at 45 degrees C than at 25 degrees C. Monitoring the cellular situation by DnaJ as nonnative protein sensor and GrpE as thermosensor thus directly adapts the operational mode of the DnaK system to heat shock conditions. Adenosine Diphosphate 31-34 GrpE like 1, mitochondrial Homo sapiens 334-338 21569335-7 2011 After carotid ferric chloride injury, EMILIN2 was abundantly expressed in the thrombus and inhibition of EMILIN2 increased platelet de-aggregation after ADP-stimulated platelet aggregation. Adenosine Diphosphate 153-156 elastin microfibril interfacer 2 Mus musculus 105-112 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 30-51 CD40 molecule Homo sapiens 244-248 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 53-56 CD40 molecule Homo sapiens 244-248 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 40-43 myosin VA Gallus gallus 77-86 21342433-12 2011 CONCLUSION: Our present data strongly suggest that the impaired platelet activation in response to U46619 in the heterozygous subject for the TXA(2)R mutation is, at least in part, as a result of the decrease in ADP secretion. Adenosine Diphosphate 212-215 thromboxane A2 receptor Homo sapiens 142-149 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 87-90 myosin VA Gallus gallus 77-86 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 87-90 myosin VA Gallus gallus 77-86 21399626-0 2011 Structure of mammalian AMPK and its regulation by ADP. Adenosine Diphosphate 50-53 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 23-27 16917816-2 2006 Recent kinetic studies have shown that myosin VI displays altered ADP release kinetics under different load conditions allowing myosin VI to serve alternately as a transporter or as an actin tether. Adenosine Diphosphate 66-69 myosin VI Homo sapiens 39-48 21399626-5 2011 Our studies show that active mammalian AMPK displays significantly tighter binding to ADP than to Mg-ATP, explaining how the enzyme is regulated under physiological conditions where the concentration of Mg-ATP is higher than that of ADP and much higher than that of AMP. Adenosine Diphosphate 86-89 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 21399626-5 2011 Our studies show that active mammalian AMPK displays significantly tighter binding to ADP than to Mg-ATP, explaining how the enzyme is regulated under physiological conditions where the concentration of Mg-ATP is higher than that of ADP and much higher than that of AMP. Adenosine Diphosphate 233-236 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 39-43 16824188-4 2006 Surprisingly, in Fg/VWF(-/-) plasma without anticoagulant, adenosine diphosphate induced robust aggregation of Fg/VWF(-/-) platelets but not of beta(3)-integrin-deficient (beta(3) (-/-)) platelets. Adenosine Diphosphate 59-80 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 172-179 21330475-5 2011 PAR1-activating peptide (PAR1-AP), adenosine diphosphate (via P2Y1/P2Y12), and glycoprotein VI-targeting collagen-related peptide induced massive SDF-1alpha and VEGF but modest PF4 or no endostatin release. Adenosine Diphosphate 35-56 purinergic receptor P2Y12 Homo sapiens 67-72 16849321-5 2006 The inefficient removal of product inhibition associated with ADP accounts for the decreased stimulation of PDK3 activity by these L2 variants. Adenosine Diphosphate 62-65 pyruvate dehydrogenase kinase 3 Homo sapiens 108-112 20946295-6 2011 Following ADP stimulation, the percentage of both CD62P and PAC1 positive platelets increased in a dose dependent fashion, even 8 h after the blood was collected. Adenosine Diphosphate 10-13 dual specificity phosphatase 2 Homo sapiens 60-64 16944299-4 2006 In order to understand the differences between the wild type and the S120G mutant, we have determined the structure of both mutant and wild type NDPK-A in complex with ADP. Adenosine Diphosphate 168-171 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 145-151 16843179-14 2006 CONCLUSIONS: The P2Y12-dependent and -independent pathways of platelet reactivity are altered in T2DM compared with nondiabetic patients, and ITDM have greater ADP-induced platelet aggregation compared with NITDM. Adenosine Diphosphate 160-163 purinergic receptor P2Y12 Homo sapiens 17-22 21325829-9 2011 CONCLUSION: These data reveal a close association of elevated mitochondrial ATP/ADP transportation via ANT1 with increased contractile function. Adenosine Diphosphate 80-83 solute carrier family 25 member 4 Rattus norvegicus 103-107 16794575-4 2006 We have now determined the structure of the kinase domain of human Chk2 in complexes with ADP and a small-molecule inhibitor debromohymenialdisine. Adenosine Diphosphate 90-93 checkpoint kinase 2 Homo sapiens 67-71 16672190-2 2006 The activities of ecto-nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) and ecto 5"-nucleotidase were assessed by measuring the levels of ATP, ADP and AMP hydrolysis in the crude membrane preparations obtained from injured left cortex, right cortex, left and right caudate nucleus, whole hippocampus and cerebellum. Adenosine Diphosphate 151-154 5' nucleotidase, ecto Rattus norvegicus 84-104 21231822-2 2011 The P2Y12 receptor, activated by ADP, plays a central role in platelet activation and thrombus formation. Adenosine Diphosphate 33-36 purinergic receptor P2Y12 Homo sapiens 4-9 16941047-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y(1) and P2Y(12)) plays a very important role in thrombogenesis. Adenosine Diphosphate 19-43 purinergic receptor P2Y12 Homo sapiens 90-97 16941047-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y(1) and P2Y(12)) plays a very important role in thrombogenesis. Adenosine Diphosphate 45-48 purinergic receptor P2Y12 Homo sapiens 90-97 16706985-0 2006 Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation. Adenosine Diphosphate 17-20 RAP1B, member of RAS oncogene family Homo sapiens 120-125 16706985-12 2006 CONCLUSIONS: Our data indicate that the continuous interaction between released ADP and P2Y12 is critical for the maintenance of alpha(IIb)beta3 activation. Adenosine Diphosphate 80-83 purinergic receptor P2Y12 Homo sapiens 88-93 16791740-2 2006 Aimed at understanding the structural basis for the conformational changes accompanying the substrate-transportation cycle, we have studied the C-terminal nucleotide-binding domain of ABCB6 (ABCB6-C) in both the nucleotide-free and ADP-bound states by heteronuclear multidimensional NMR and homology modelling. Adenosine Diphosphate 232-235 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 184-189 16791740-2 2006 Aimed at understanding the structural basis for the conformational changes accompanying the substrate-transportation cycle, we have studied the C-terminal nucleotide-binding domain of ABCB6 (ABCB6-C) in both the nucleotide-free and ADP-bound states by heteronuclear multidimensional NMR and homology modelling. Adenosine Diphosphate 232-235 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 191-198 16791740-6 2006 These localised conformational dynamics remained in ADP-bound ABCB6-C except for the loops responsible for adenine base and alpha/beta-phosphate binding. Adenosine Diphosphate 52-55 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 62-67 22022533-6 2011 The platelet antagonists [cangrelor, MRS2179, and apyrase] inhibited 59M cell induced activation suggesting a P2Y12 and P2Y1 receptor mediated mechanism of platelet activation dependent on the release of ADP by 59M cells. Adenosine Diphosphate 204-207 purinergic receptor P2Y12 Homo sapiens 110-115 16585511-8 2006 Cells with low levels of VDAC1 showed 4-fold-lower ATP-synthesis capacity and contained low ATP and ADP levels, with a strong correlation between ATP levels and cell growth, suggesting limited metabolite exchange between mitochondria and cytosol. Adenosine Diphosphate 100-103 voltage dependent anion channel 1 Homo sapiens 25-30 16519518-1 2006 Phosphomevalonate kinase (PMK) catalyzes a key step in isoprenoid/sterol biosynthesis, converting mevalonate 5-phosphate and ATP to mevalonate 5-diphosphate and ADP. Adenosine Diphosphate 161-164 phosphomevalonate kinase Homo sapiens 0-24 21095583-5 2010 PARP-1 dissociates Smad complexes from DNA by ADP-ribosylating Smad3 and Smad4, which attenuates Smad-specific gene responses and TGF-beta-induced epithelial-mesenchymal transition. Adenosine Diphosphate 46-49 SMAD family member 4 Homo sapiens 63-67 16519518-1 2006 Phosphomevalonate kinase (PMK) catalyzes a key step in isoprenoid/sterol biosynthesis, converting mevalonate 5-phosphate and ATP to mevalonate 5-diphosphate and ADP. Adenosine Diphosphate 161-164 phosphomevalonate kinase Homo sapiens 26-29 20725852-8 2010 Our findings indicate that the differences between liver and kidney mitochondria are due to the low association of cyclophilin D to the ADP/ATP carrier found in kidney mitochondria as compared to liver mitochondria. Adenosine Diphosphate 136-139 peptidylprolyl isomerase D Homo sapiens 115-128 16308186-6 2006 We also found a strong correlation (p < 0.01) between the ADP-stimulated RI and the expression of CD62P after stimulation with 2 microM ADP, whereas no correlation was seen for RI vs. binding of PAC-1 or aggregation. Adenosine Diphosphate 61-64 dual specificity phosphatase 2 Homo sapiens 198-203 20681951-0 2010 TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. Adenosine Diphosphate 26-29 purinergic receptor P2Y12 Homo sapiens 85-90 20681951-5 2010 Then, we found that migratory capability and expression of both P2Y receptors were abrogated in microglial cells from LPS-stimulated mixed glial cultures, while TGF-beta increased ADP-induced migration and the expression of P2Y12 and P2Y1 receptors. Adenosine Diphosphate 180-183 purinergic receptor P2Y12 Homo sapiens 224-229 16388602-0 2006 Reversal of ADP-mediated aggregation of adenosine kinase by cyclophilin leads to its reactivation. Adenosine Diphosphate 12-15 cyclophilin Leishmania donovani 60-71 20850010-7 2010 Switching between these two mechanisms in a strain-sensitive, ADP-dependent manner allows myosin VI to fulfill its multiple cellular tasks including vesicle transport and membrane anchoring. Adenosine Diphosphate 62-65 myosin VI Homo sapiens 90-99 20569198-0 2010 Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state. Adenosine Diphosphate 58-61 aconitase 1 Homo sapiens 15-40 20569198-0 2010 Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state. Adenosine Diphosphate 58-61 aconitase 1 Homo sapiens 42-47 20569198-9 2010 Upon incubation of IRP-1 with increasing concentrations of ATP or ADP, the protein migrates more slowly on agarose gel electrophoresis, and there is a shift in the CD spectrum. Adenosine Diphosphate 66-69 aconitase 1 Homo sapiens 19-24 20569198-10 2010 In this new state, adenosine nucleotide binding is competed for by other nucleotides (CTP, GTP and AMP-PNP), although ATP and ADP, but not the other nucleotides, partially stabilize the protein against spontaneous loss of aconitase activity when incubated at 37 degrees C. A mutant IRP-1(C437S) lacking aconitase activity shows only one ATP-binding site and lacks co-operativity. Adenosine Diphosphate 126-129 aconitase 1 Homo sapiens 282-287 20569198-12 2010 Under normal cellular conditions, it is predicted that ATP/ADP will maintain IRP-1 in a non-IRE-binding state. Adenosine Diphosphate 59-62 aconitase 1 Homo sapiens 77-82 20718861-7 2010 In an in vitro assay, intact ETA induced ADP-ribosylation of EF-2 and mitochondrial release of cytochrome c, with the former effect being efficiently increased by a cathepsin B/cathepsin D pretreatment. Adenosine Diphosphate 41-44 endothelin receptor type A Rattus norvegicus 29-32 20553499-9 2010 We suggest that the lower ATPase activity of SUR2B may result in enhanced duration of the MgADP-bound state, leading to channel activation. Adenosine Diphosphate 90-95 dynein axonemal heavy chain 8 Homo sapiens 26-32 20141534-1 2010 The mitochondrial ADP/ATP carrier (Aac2p) of Saccharomyces cerevisiae links two biochemical pathways, glycolysis in the cytosol and oxidative phosphorylation in the mitochondria, by exchanging their common substrates and products across the inner mitochondrial membrane. Adenosine Diphosphate 18-21 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 35-40 20424264-4 2010 Crystal structures of CASK(4M) with and without bound nucleotide and Mn(2+), together with kinetic analyses, demonstrated that Mg(2+) accelerates catalysis of CASK(4M) by stabilizing the transition state, enhancing the leaving group properties of adenosine 5"-diphosphate, and indirectly shifting the position of the gamma-phosphate of ATP. Adenosine Diphosphate 247-271 calcium/calmodulin dependent serine protein kinase Homo sapiens 159-163 20189992-6 2010 Inhibitory effect of PP2 on platelet aggregation induced by thrombin and thromboxane A(2) were also reversed by supplementing ADP. Adenosine Diphosphate 126-129 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 21-24 19812088-1 2010 A conventional five-step chemo-mechanical cycle of the myosin-actin ATPase reaction, which implies myosin detachment from actin upon release of hydrolysis products (ADP and phosphate, Pi) and binding of a new ATP molecule, is able to fit the [Pi] dependence of the force and number of myosin motors during isometric contraction of skeletal muscle. Adenosine Diphosphate 165-168 dynein axonemal heavy chain 8 Homo sapiens 68-74 19858214-5 2009 The GST pull-down assay and ELISA assay show that Cdc37 binds to ADP-bound/nucleotide-free Hsp90 but not ATP-bound Hsp90. Adenosine Diphosphate 65-68 cell division cycle 37, HSP90 cochaperone Homo sapiens 50-55 19700402-10 2009 These results demonstrate that GPVI-induced Akt activation in platelets is dependent in part on G(i) stimulation through P2Y(12) receptor activation by secreted ADP. Adenosine Diphosphate 161-164 glycoprotein 6 (platelet) Mus musculus 31-35 19741014-4 2009 Inhibition of cyclophilin D by cyclosporine A (CsA) effectively opposed the MPT only in the presence of ADP and/or Mg(2+). Adenosine Diphosphate 104-107 peptidylprolyl isomerase D Homo sapiens 14-27 19740098-5 2009 CONCLUSIONS: These results indicate that genetic polymorphisms in ITGA2 and P2RY1 combine with plasma VWF:Ag levels to modulate baseline platelet reactivity in response to collagen plus EPI, while genetic differences in P2RY1 and GP1BA significantly effect platelet responses to collagen plus ADP. Adenosine Diphosphate 293-296 integrin subunit alpha 2 Homo sapiens 66-71 19733667-2 2009 Extracellular ADP was reported to induce microglia chemotaxis and membrane ruffles through P2Y12 receptor. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 91-96 17379941-10 2006 Binding of ATP and subsequent hydrolysis and release of ADP would advance the ATPase hexamer ratchet thereby both thinning the membrane and increasing the vesicle surface. Adenosine Diphosphate 56-59 dynein axonemal heavy chain 8 Homo sapiens 78-84 19733667-3 2009 In this study, we examined the role of VASP phosphorylation in ADP-induced microglia chemotaxis and membrane ruffle formation. Adenosine Diphosphate 63-66 vasodilator stimulated phosphoprotein Homo sapiens 39-43 19733667-4 2009 ADP stimulation transiently increased intracellular cAMP level, VASP phosphorylation at Ser153, membrane ruffle formation, and chemotaxis. Adenosine Diphosphate 0-3 vasodilator stimulated phosphoprotein Homo sapiens 64-68 19733667-8 2009 VASP knockdown cells showed markedly reduced frequency and distance of membrane ruffling upon ADP stimulation, reinforcing the idea that VASP is required for the ruffle formation. Adenosine Diphosphate 94-97 vasodilator stimulated phosphoprotein Homo sapiens 0-4 19733667-8 2009 VASP knockdown cells showed markedly reduced frequency and distance of membrane ruffling upon ADP stimulation, reinforcing the idea that VASP is required for the ruffle formation. Adenosine Diphosphate 94-97 vasodilator stimulated phosphoprotein Homo sapiens 137-141 16515502-3 2006 Two receptors for ADP, the G(q)-protein-coupled P2Y1 and G(i)-protein-coupled P2Y12 and one receptor for ATP, the P2X1 ion channel, have been identified on platelets. Adenosine Diphosphate 18-21 purinergic receptor P2Y12 Homo sapiens 78-83 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 30-51 interferon induced protein 44 Homo sapiens 119-122 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 53-56 interferon induced protein 44 Homo sapiens 119-122 16685599-3 2006 TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Adenosine Diphosphate 241-244 transient receptor potential cation channel subfamily C member 3 Homo sapiens 0-5 19631608-8 2009 AT-III markedly attenuated the ADP-induced phosphorylation levels of p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 31-34 interferon induced protein 44 Homo sapiens 69-72 19631608-10 2009 These results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 85-88 interferon induced protein 44 Homo sapiens 168-171 16472655-2 2006 The C3 enzyme selectively catalyzes the ADP-ribosylation, and consequent inactivation, of RhoA, RhoB, and RhoC of the Rho GTPase protein family. Adenosine Diphosphate 40-43 ras homolog family member B Homo sapiens 96-100 19723493-3 2009 In addition, we show that the induction of GLP-1 release in enteroendocrine cells by 6alpha-ethyl-23(S)-methyl-cholic acid (EMCA, INT-777), a specific TGR5 agonist, is linked to an increase of the intracellular ATP/ADP ratio and a subsequent rise in intracellular calcium mobilization. Adenosine Diphosphate 215-218 glucagon Mus musculus 43-48 16139873-5 2006 GPVI(null) mice platelets failed to respond to a high dose of fibrillar collagen, or convulxin, a GPVI agonist, but showed a normal response to other agonists such as ADP, PMA and arachidonic acid. Adenosine Diphosphate 167-170 glycoprotein 6 (platelet) Mus musculus 0-4 19552634-10 2009 CONCLUSIONS: These data indicate that P2Y(12) is targeted by ticagrelor via a mechanism that is non-competitive with ADP, suggesting the existence of an independent receptor-binding site for CPTPs. Adenosine Diphosphate 117-120 purinergic receptor P2Y12 Homo sapiens 38-45 16417458-11 2005 At balance of quasi-equilibrium concentrations of ADP and ATP/ADP ratio the mitochondrial respiration rate in the system containing nucleoside diphosphate kinase was 21% of the respiration rate assayed in the absence of creatine phosphokinase; in the system containing yeast hexokinase this parameter was only 7% of the respiration rate assayed in the absence of creatine phosphokinase. Adenosine Diphosphate 50-53 nucleoside diphosphate kinase Saccharomyces cerevisiae S288C 132-161 16417458-11 2005 At balance of quasi-equilibrium concentrations of ADP and ATP/ADP ratio the mitochondrial respiration rate in the system containing nucleoside diphosphate kinase was 21% of the respiration rate assayed in the absence of creatine phosphokinase; in the system containing yeast hexokinase this parameter was only 7% of the respiration rate assayed in the absence of creatine phosphokinase. Adenosine Diphosphate 62-65 nucleoside diphosphate kinase Saccharomyces cerevisiae S288C 132-161 19554567-6 2009 In contrast to cytosolic Hsp90, crystal structures of the endoplasmic reticulum homolog, Grp94, show the same conformation in the presence of both ADP and AMPPNP. Adenosine Diphosphate 147-150 heat shock protein 90, beta (Grp94), member 1 Mus musculus 89-94 15927298-0 2005 Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line. Adenosine Diphosphate 19-22 Janus kinase 2 Homo sapiens 56-60 15920726-5 2005 In the present study, we report that the ADP-induced chemotaxis of microglia is mediated by P2Y12/13 receptors and is beta1 integrin-dependent in the presence of fibronectin. Adenosine Diphosphate 41-44 purinergic receptor P2Y12 Homo sapiens 92-97 16194206-6 2005 Conversely, secreted ADP strongly potentiated Rac activation induced by FcgammaRIIa clustering or TRAP via its P2Y12 receptor, the target of antithrombotic thienopyridines. Adenosine Diphosphate 21-24 purinergic receptor P2Y12 Homo sapiens 111-116 16194207-8 2005 Our data suggest that secretion of endogenous ADP and subsequent P2Y12-mediated signaling are critical for platelet aggregation, platelet spreading, and as a consequence, for stabilization of thrombus. Adenosine Diphosphate 46-49 purinergic receptor P2Y12 Homo sapiens 65-70 19253999-4 2009 The identity of the synthetic 5-PP-Ins(1,2,3,4,6)P(5) was validated using IP6K1 to catalyze the conversion of IP(7) + ADP to ATP + IP(6). Adenosine Diphosphate 118-121 inositol hexakisphosphate kinase 1 Homo sapiens 74-79 15951390-6 2005 Our results are consistent with structural rearrangements in which there is an 8.5-A closure between the 344W residue and the mant moiety during the transition from the strongly (ADP) to weakly (ATP) actin-bound states of the myosin ATPase cycle. Adenosine Diphosphate 179-182 dynein axonemal heavy chain 8 Homo sapiens 233-239 16178769-10 2005 In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. Adenosine Diphosphate 165-168 APC regulator of WNT signaling pathway Homo sapiens 88-91 16178769-10 2005 In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. Adenosine Diphosphate 165-168 CD80 molecule Homo sapiens 93-97 16178769-10 2005 In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. Adenosine Diphosphate 165-168 CD86 molecule Homo sapiens 99-103 19150400-5 2009 Contrary to the mild uncoupling hypothesis, UCP4 overexpression resulted in increased absolute ATP levels (with ADP/ATP ratios similar to those of controls under normal conditions and ADP supplementation) associated with increased respiration rate. Adenosine Diphosphate 112-115 solute carrier family 25 member 27 Homo sapiens 44-48 16154027-8 2005 Finally, the H1/H2 polymorphism of the platelet ADP receptor P2Y12 gene has been associated with ADP-induced platelet aggregation response and peripheral arterial disease. Adenosine Diphosphate 48-51 purinergic receptor P2Y12 Homo sapiens 61-66 16268477-3 2005 In the present study, we determined the stereoselectivity of P2Y12 antagonist effects by assessing the antagonism of the [3H]-2-MeS-ADP that binds to human P2Y12 receptors expressed in Chinese hamster ovary cells as an affinity assay, and by the inhibition of ADP-induced aggregation of washed human platelets as a functional assay. Adenosine Diphosphate 132-135 purinergic receptor P2Y12 Homo sapiens 61-66 16268477-3 2005 In the present study, we determined the stereoselectivity of P2Y12 antagonist effects by assessing the antagonism of the [3H]-2-MeS-ADP that binds to human P2Y12 receptors expressed in Chinese hamster ovary cells as an affinity assay, and by the inhibition of ADP-induced aggregation of washed human platelets as a functional assay. Adenosine Diphosphate 132-135 purinergic receptor P2Y12 Homo sapiens 156-161 15961399-8 2005 The steady-state ATPase rate can be explained by a combination of the unfavorable equilibrium constant of the hydrolysis step and the relatively slow ADP off-rate. Adenosine Diphosphate 150-153 dynein axonemal heavy chain 8 Homo sapiens 17-23 15831706-5 2005 Sema3A dose-dependently inhibited activation of integrin alphaIIbbeta3 by all agonists examined including adenosine diphosphate (ADP), thrombin, convulxin, phorbol 12-myristate 13-acetate, and A23187. Adenosine Diphosphate 106-127 semaphorin 3A Homo sapiens 0-6 15831706-5 2005 Sema3A dose-dependently inhibited activation of integrin alphaIIbbeta3 by all agonists examined including adenosine diphosphate (ADP), thrombin, convulxin, phorbol 12-myristate 13-acetate, and A23187. Adenosine Diphosphate 129-132 semaphorin 3A Homo sapiens 0-6 15757892-0 2005 The average conformation at micromolar [Ca2+] of Ca2+-atpase with bound nucleotide differs from that adopted with the transition state analog ADP.AlFx or with AMPPCP under crystallization conditions at millimolar [Ca2+]. Adenosine Diphosphate 142-145 dynein axonemal heavy chain 8 Homo sapiens 54-60 15795539-2 2005 Recently, a P2Y12 haplotype was shown to be associated with enhanced adenosine diphosphate (ADP)-induced platelet aggregation in healthy volunteers. Adenosine Diphosphate 69-90 purinergic receptor P2Y12 Homo sapiens 12-17 15795539-2 2005 Recently, a P2Y12 haplotype was shown to be associated with enhanced adenosine diphosphate (ADP)-induced platelet aggregation in healthy volunteers. Adenosine Diphosphate 92-95 purinergic receptor P2Y12 Homo sapiens 12-17 15766878-1 2005 A recombinant fusion protein combining the mitochondrial ADP/ATP carrier (Anc2p) and the iso-1-cytochrome c (Cyc1p), both from Saccharomyces cerevisiae, has been genetically elaborated with the aim of increasing the polar surface area of the carrier to facilitate its crystallization. Adenosine Diphosphate 57-60 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 74-79 15766878-3 2005 The chimeric carrier, Anc2-Cyc1(His6)p, was able to restore growth on a non-fermentable carbon source of a yeast strain devoid of functional ADP/ATP carrier, which demonstrated its transport activity. Adenosine Diphosphate 141-144 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 22-26 15766878-6 2005 Purification of Anc2-Cyc1(His6)p in complex with carboxyatractyloside (CATR), a high affinity inhibitor of ADP/ATP transport, was achieved by combining ion-exchange chromatography and ion-metal affinity chromatography in the presence of LAPAO, an aminoxide detergent. Adenosine Diphosphate 107-110 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 16-20 15766878-8 2005 Large-scale purification of Anc2-Cyc1(His6)p-CATR complex opens up novel possibilities for the use of crystallographic approaches to the yeast ADP/ATP carrier. Adenosine Diphosphate 143-146 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 28-32 15786005-7 2005 GPIIb/IIIa function was evaluated with the activation-specific antibody PAC-1 after stimulation with 10 microM ADP. Adenosine Diphosphate 111-114 dual specificity phosphatase 2 Homo sapiens 72-77 15740751-9 2005 The domains within each protomer of the hexameric p97/VCP deviate from strict 6-fold symmetry, with the more flexible ADP state exhibiting greater asymmetry compared to the relatively rigid ADP x AlF3 state, suggesting a mechanism of action in which hydrolysis and conformational changes move about the hexamer in a processive fashion. Adenosine Diphosphate 118-121 valosin containing protein Homo sapiens 50-53 15740751-9 2005 The domains within each protomer of the hexameric p97/VCP deviate from strict 6-fold symmetry, with the more flexible ADP state exhibiting greater asymmetry compared to the relatively rigid ADP x AlF3 state, suggesting a mechanism of action in which hydrolysis and conformational changes move about the hexamer in a processive fashion. Adenosine Diphosphate 118-121 valosin containing protein Homo sapiens 54-57 15740751-9 2005 The domains within each protomer of the hexameric p97/VCP deviate from strict 6-fold symmetry, with the more flexible ADP state exhibiting greater asymmetry compared to the relatively rigid ADP x AlF3 state, suggesting a mechanism of action in which hydrolysis and conformational changes move about the hexamer in a processive fashion. Adenosine Diphosphate 190-193 valosin containing protein Homo sapiens 50-53 15740751-9 2005 The domains within each protomer of the hexameric p97/VCP deviate from strict 6-fold symmetry, with the more flexible ADP state exhibiting greater asymmetry compared to the relatively rigid ADP x AlF3 state, suggesting a mechanism of action in which hydrolysis and conformational changes move about the hexamer in a processive fashion. Adenosine Diphosphate 190-193 valosin containing protein Homo sapiens 54-57 15602005-3 2005 Plasma membranes from ADP-stimulated platelets also retained P2Y12 activity. Adenosine Diphosphate 22-25 purinergic receptor P2Y12 Homo sapiens 61-66 15563471-2 2005 Using purified recombinant IRK fragments and the isolated intact insulin receptor, we show here that autophosphorylation is inhibited by ADP and that this effect is essentially reversed by hydrogen peroxide. Adenosine Diphosphate 137-140 insulin receptor Homo sapiens 65-81 15604418-0 2005 ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 14-19 15604418-3 2005 In this study, we show that ADP acting on P2Y13 receptors on red blood cells serves as a negative feedback pathway for the inhibition of ATP release. Adenosine Diphosphate 28-31 purinergic receptor P2Y13 Homo sapiens 42-47 15604418-10 2005 Our results indicate that the ATP degradation product ADP inhibits ATP release by acting on the red blood cell P2Y13 receptor. Adenosine Diphosphate 54-57 purinergic receptor P2Y13 Homo sapiens 111-116 15654602-9 2005 In particular, UCP-2 expression is increased (probably due to a condition of fuel overload), which leads to lower ATP, decreased ATP/ADP ratio, with consequent reduction of insulin release. Adenosine Diphosphate 133-136 uncoupling protein 2 Homo sapiens 15-20 15698232-2 2005 We show that the quality of the biological switch consisting of a phosphorylation-dephosphorylation cycle, such as those in protein kinase cascade, is controlled by the available intracellular free energy from the adenosine triphosphate (ATP) hydrolysis in vivo: DeltaG=k(B)Tln(([ATP]/K(eq)[ADP]), where K(eq) is the equilibrium constant. Adenosine Diphosphate 291-294 intercellular adhesion molecule 5 Homo sapiens 274-277 15652174-1 2005 Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme that hydrolyzes ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0. Adenosine Diphosphate 154-157 tripartite motif containing 33 Homo sapiens 46-50 15531589-9 2005 Surprisingly, newly formed RhoB protein was only partially glucosylated by toxin A, sparing a pool of potentially active RhoB, as checked by sequential C3bot-catalyzed ADP-ribosylation. Adenosine Diphosphate 168-171 ras homolog family member B Homo sapiens 27-31 19150400-5 2009 Contrary to the mild uncoupling hypothesis, UCP4 overexpression resulted in increased absolute ATP levels (with ADP/ATP ratios similar to those of controls under normal conditions and ADP supplementation) associated with increased respiration rate. Adenosine Diphosphate 184-187 solute carrier family 25 member 27 Homo sapiens 44-48 15291552-3 2004 Fhit catalyzes the Mg2+-dependent hydrolysis of P1-5"-O-adenosine-P3-5"-O-adenosine triphosphate (Ap3A) to AMP and MgADP. Adenosine Diphosphate 115-120 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 18948190-2 2009 We have previously demonstrated on human hepatocytes that apolipoprotein A-I binding to an ectopic F(1)-ATPase stimulates the production of extracellular ADP that activates a P2Y(13)-mediated high-density lipoprotein (HDL) endocytosis pathway. Adenosine Diphosphate 154-157 purinergic receptor P2Y13 Homo sapiens 175-182 19063607-6 2008 Previously, we demonstrated that mutation of D793 to Glu was sufficient to increase ATP hydrolysis at NBS1, but paradoxically, transport activity decreased by 50-70% as a result of tight binding of ADP at the mutated NBS1. Adenosine Diphosphate 198-201 NLR family pyrin domain containing 2 Homo sapiens 102-106 15254768-5 2004 After cloning and sequencing three known genes, ribosomal protein L19 (RPL19), ADP/ATP carrier protein and ErbB-2 with high-elevated mRNA levels in SKBR3 were identified. Adenosine Diphosphate 79-82 ribosomal protein L19 Homo sapiens 48-69 19063607-6 2008 Previously, we demonstrated that mutation of D793 to Glu was sufficient to increase ATP hydrolysis at NBS1, but paradoxically, transport activity decreased by 50-70% as a result of tight binding of ADP at the mutated NBS1. Adenosine Diphosphate 198-201 NLR family pyrin domain containing 2 Homo sapiens 217-221 19063607-8 2008 We found that conversion of Trp653 to Tyr and/or Pro794 to Ala enhanced transport activity of the D793E mutant and the release of ADP from NBS1. Adenosine Diphosphate 130-133 NLR family pyrin domain containing 2 Homo sapiens 139-143 19073762-3 2008 Functional integration of Gm PNC1 and At PNC2 into the cytoplasmic membranes of intact Escherichia coli cells revealed ATP and ADP import activities. Adenosine Diphosphate 127-130 peroxisomal adenine nucleotide carrier 1 Arabidopsis thaliana 29-33 15194469-14 2004 Similarly to PAF, Lp(a) inhibits platelet aggregation induced by ADP or Calcium ionophore A23187. Adenosine Diphosphate 65-68 lipoprotein(a) Homo sapiens 18-23 15194469-15 2004 Lp(a), pefa-Lp(a) or Lp(a-) effectively inhibited PAF- or ADP-induced surface expression of alphaIIbbeta3, the Lp(a-) being more potent compared to Lp(a) or to pefa-Lp(a). Adenosine Diphosphate 58-61 lipoprotein(a) Homo sapiens 0-5 15194469-15 2004 Lp(a), pefa-Lp(a) or Lp(a-) effectively inhibited PAF- or ADP-induced surface expression of alphaIIbbeta3, the Lp(a-) being more potent compared to Lp(a) or to pefa-Lp(a). Adenosine Diphosphate 58-61 lipoprotein(a) Homo sapiens 12-17 15194469-15 2004 Lp(a), pefa-Lp(a) or Lp(a-) effectively inhibited PAF- or ADP-induced surface expression of alphaIIbbeta3, the Lp(a-) being more potent compared to Lp(a) or to pefa-Lp(a). Adenosine Diphosphate 58-61 lipoprotein(a) Homo sapiens 12-17 15194469-15 2004 Lp(a), pefa-Lp(a) or Lp(a-) effectively inhibited PAF- or ADP-induced surface expression of alphaIIbbeta3, the Lp(a-) being more potent compared to Lp(a) or to pefa-Lp(a). Adenosine Diphosphate 58-61 lipoprotein(a) Homo sapiens 12-17 15213852-14 2004 Our data indicate that both primary signalling through Gq, which evokes ADP secretion, as well as subsequent coupling via Gi by the P2Y12 receptor are required for ERK2 activation. Adenosine Diphosphate 72-75 purinergic receptor P2Y12 Homo sapiens 132-137 19073763-6 2008 Complementation of a yeast mutant deficient in peroxisomal ATP import and in vitro transport assays using recombinant transporter proteins revealed that PNC1 and PNC2 catalyze the counterexchange of ATP with ADP or AMP. Adenosine Diphosphate 208-211 nicotinamidase Saccharomyces cerevisiae S288C 153-157 18832777-6 2008 Levels of VASP phosphorylated at Ser157 were correlated and the maximal aggregation rates induced by ADP were inversely correlated with cilostazol concentrations in the plasma. Adenosine Diphosphate 101-104 vasodilator stimulated phosphoprotein Homo sapiens 10-14 15154840-4 2004 The immobilized ATPase/synthase was used for generation of ATP from ADP and P(i) at the expense of electrochemical potential energy. Adenosine Diphosphate 68-71 dynein axonemal heavy chain 8 Homo sapiens 16-22 18497752-6 2008 The results indicate that the ATPase cycle lingers in the post-hydrolytic MgADP.P(i)-bound state, which is associated with channel activation. Adenosine Diphosphate 74-79 dynein axonemal heavy chain 8 Homo sapiens 30-36 14645014-8 2004 These results indicate a central role for ADP-mediated P2Y1 and P2Y12 receptor activation in supporting LPA-induced platelet aggregation. Adenosine Diphosphate 42-45 purinergic receptor P2Y12 Homo sapiens 64-69 18260128-2 2008 Metastatic tumor cells can produce platelet alphaIIb beta3 activators, such as ADP and thromboxane A(2) (TXA(2)). Adenosine Diphosphate 79-82 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 53-58 15045137-9 2004 Agonist-stimulation of platelets resulted in a significant release of CTGF from the storage granules, with thrombin at 0.1 U/mL being a more potent activator than ADP at 20 micro mol/L. Adenosine Diphosphate 163-166 cellular communication network factor 2 Homo sapiens 70-74 18218635-4 2008 The interaction triggers release of bound ADP from Ssa1, but nucleotide persists bound to Sse1 in the complex. Adenosine Diphosphate 42-45 adenyl-nucleotide exchange factor SSE1 Saccharomyces cerevisiae S288C 90-94 15003454-3 2004 The crystal structure of GalK from Pyrococcus furiosus in complex with MgADP and galactose has been determined to 2.9 A resolution to provide insights into the substrate specificity and catalytic mechanism of the enzyme. Adenosine Diphosphate 71-76 galactokinase 1 Homo sapiens 25-29 18213371-1 2008 BACKGROUND AND AIMS: The aims of this study were to investigate (1) if P2Y(12) polymorphisms defining the P2Y(12) H2 allele are associated with any other SNPs that may explain the previously reported association with increased ADP induced platelet activation and association with peripheral arterial disease and coronary artery disease and (2) if such variants are associated with acute myocardial infarction (AMI) or classical risk factors for AMI. Adenosine Diphosphate 227-230 purinergic receptor P2Y12 Homo sapiens 71-78 12796499-7 2003 However, the second wave of platelet aggregation was restored by addition of exogenous ADP to PI3Kgamma deficient or PI3K inhibitor-treated platelets. Adenosine Diphosphate 87-90 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 94-103 12736270-4 2003 In ADP and AMPPNP, GroES bound quickly to GroEL but bound very slowly to the GroEL loaded with unfolded rhodanese or malate dehydrogenase. Adenosine Diphosphate 3-6 heat shock protein family E (Hsp10) member 1 Homo sapiens 19-24 12670938-1 2003 Kinetics of inhibition of ATPase activity of pure mouse Mdr3 P-glycoprotein upon incubation with MgADP and vanadate were studied along with the trapping of [14C]ADP in presence of vanadate. Adenosine Diphosphate 97-102 dynein, axonemal, heavy chain 8 Mus musculus 26-32 12670938-1 2003 Kinetics of inhibition of ATPase activity of pure mouse Mdr3 P-glycoprotein upon incubation with MgADP and vanadate were studied along with the trapping of [14C]ADP in presence of vanadate. Adenosine Diphosphate 97-102 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 56-60 12670938-1 2003 Kinetics of inhibition of ATPase activity of pure mouse Mdr3 P-glycoprotein upon incubation with MgADP and vanadate were studied along with the trapping of [14C]ADP in presence of vanadate. Adenosine Diphosphate 99-102 dynein, axonemal, heavy chain 8 Mus musculus 26-32 12670938-1 2003 Kinetics of inhibition of ATPase activity of pure mouse Mdr3 P-glycoprotein upon incubation with MgADP and vanadate were studied along with the trapping of [14C]ADP in presence of vanadate. Adenosine Diphosphate 99-102 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 56-60 17822411-7 2007 Expression of a mutated form of Aac2p (op1) exhibiting very low ADP/ATP translocase activity indicates that AAC"s pro-death role does not require translocase activity. Adenosine Diphosphate 64-67 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 32-37 17294140-11 2007 Thus, ADP acting on the endothelial P2Y(1) receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP. Adenosine Diphosphate 6-9 purinergic receptor P2Y1 Sus scrofa 36-51 12533443-5 2003 Additionally, ADP activated mucin release from HBE xenografts, whereas UDP and 2-methlythio-ADP did not, a pattern of response inconsistent with known purinoceptors. Adenosine Diphosphate 14-17 LOC100508689 Homo sapiens 28-33 17538005-5 2007 After ADP stimulation, mean fluorescence intensity of LOX-1 expression on platelets increased 1.5- to 2.0-fold. Adenosine Diphosphate 6-9 oxidized low density lipoprotein receptor 1 Homo sapiens 54-59 13678275-6 2003 ADP/ATP exchange mediated by Anc2p variants in isolated mitochondria was more efficient than that of the wild-type Anc2p in the presence of BA, confirming that BA resistance of the mutant cells was linked to the functional properties of the modified ADP/ATP carrier. Adenosine Diphosphate 250-253 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 29-34 17538005-6 2007 Blocking LOX-1 inhibited ADP-induced platelet aggregation in a concentration- and time-dependent manner. Adenosine Diphosphate 25-28 oxidized low density lipoprotein receptor 1 Homo sapiens 9-14 17538005-7 2007 We also established that LOX-1 is important for ADP-stimulated inside-out activation of platelet alpha(IIb)beta(3) and alpha(2)beta(1) integrins (fibrinogen receptors). Adenosine Diphosphate 48-51 oxidized low density lipoprotein receptor 1 Homo sapiens 25-30 17538005-14 2007 Thus, LOX-1 is important for ADP-mediated platelet integrin activation, possibly through protein kinase C activation. Adenosine Diphosphate 29-32 oxidized low density lipoprotein receptor 1 Homo sapiens 6-11 12639955-11 2003 Thus, the long helix pair in the GrpE dimer acts as a thermosensor that, by decreasing its ADP/ATP exchange activity, induces a shift of the DnaK.substrate complexes toward the high affinity R state and in this way adapts the DnaK/DnaJ/GrpE system to heat shock conditions. Adenosine Diphosphate 91-94 GrpE like 1, mitochondrial Homo sapiens 33-37 17551507-3 2007 Combining Ad5-yCD/mutTK(SR39)rep-ADP-mediated suicide gene therapy with radiation significantly increased tumor control beyond that of either modality alone. Adenosine Diphosphate 33-36 Alzheimer disease, familial, type 5 Homo sapiens 10-13 12639955-11 2003 Thus, the long helix pair in the GrpE dimer acts as a thermosensor that, by decreasing its ADP/ATP exchange activity, induces a shift of the DnaK.substrate complexes toward the high affinity R state and in this way adapts the DnaK/DnaJ/GrpE system to heat shock conditions. Adenosine Diphosphate 91-94 GrpE like 1, mitochondrial Homo sapiens 236-240 12732502-2 2003 Although platelets do not contain detectable levels of TSP2, TSP2-null platelets are compromised in their ability to aggregate in vivo in response to denudation of the carotid artery endothelium, and in vitro following exposure to adenosine diphosphate (ADP). Adenosine Diphosphate 231-252 thrombospondin 2 Mus musculus 61-65 17324236-6 2007 In normoxic conditions, HXK overexpression resulted in higher ADP and AMP levels only in roots of AtHXK1 transgenic plants. Adenosine Diphosphate 62-65 hexokinase Solanum lycopersicum 24-27 12732502-2 2003 Although platelets do not contain detectable levels of TSP2, TSP2-null platelets are compromised in their ability to aggregate in vivo in response to denudation of the carotid artery endothelium, and in vitro following exposure to adenosine diphosphate (ADP). Adenosine Diphosphate 254-257 thrombospondin 2 Mus musculus 61-65 17200114-4 2007 Although both PAR1-AP and PAR4-AP induced ADP secretion, which is required for platelet spreading, only PAR4-AP induced sustained Ca(2+) mobilization. Adenosine Diphosphate 42-45 Prader Willi/Angelman region RNA 4 Homo sapiens 26-30 12777794-5 2003 D59, 783-794] enclose chain segments of symmetry-related monomers in the GroEL-GroES-(ADP)(7) chaperonin complex. Adenosine Diphosphate 86-89 heat shock protein family E (Hsp10) member 1 Homo sapiens 79-84 17200114-6 2007 p38 phosphorylation was dependent on ADP signaling through P2Y12, its receptor. Adenosine Diphosphate 37-40 purinergic receptor P2Y12 Homo sapiens 59-64 17092635-9 2007 Moreover, STC-1 uncoupled oxidative phosphorylation as ADP:O ratios were significantly reduced in mitochondria from both tissues. Adenosine Diphosphate 55-58 stanniocalcin 1 Homo sapiens 10-15 14577157-5 2003 However, the addition of the co-chaperonin GroES together with ADP (i.e. the formation of the complex of GroEL with GroES) leads to drastic weakness of the interaction of GroEL with nonnative lysozyme and the efficiency of its aggregation becomes comparable with that in the absence of GroEL. Adenosine Diphosphate 63-66 heat shock protein family E (Hsp10) member 1 Homo sapiens 43-48 14577157-5 2003 However, the addition of the co-chaperonin GroES together with ADP (i.e. the formation of the complex of GroEL with GroES) leads to drastic weakness of the interaction of GroEL with nonnative lysozyme and the efficiency of its aggregation becomes comparable with that in the absence of GroEL. Adenosine Diphosphate 63-66 heat shock protein family E (Hsp10) member 1 Homo sapiens 116-121 17210842-4 2007 Cardiac-specific ANT1 overexpression resulted in a higher ATP/ADP transportation and elevated activities of respiratory chain complexes. Adenosine Diphosphate 62-65 solute carrier family 25 member 4 Rattus norvegicus 17-21 12653548-3 2003 Presented here are the structures of apo bovine GDH, bovine GDH complexed with ADP, and the R463A mutant form of human GDH (huGDH) that is insensitive to ADP activation. Adenosine Diphosphate 79-82 glutamate dehydrogenase 1, mitochondrial Bos taurus 60-63 16939417-5 2007 Depletion of the DTS using ADP, which releases Ca2+ solely from the DTS, in combination with 10 nM TG, to selectively inhibit SERCA2 located on the DTS reduced Ca2+ release evoked by the PAR-1 agonist, SFLLRN, and the PAR-4 agonist, AYPGKF, by 80 and 50% respectively. Adenosine Diphosphate 27-30 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Homo sapiens 126-132 16857990-0 2006 G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases. Adenosine Diphosphate 64-67 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 76-81 12485953-1 2003 The prodrug clopidogrel (Plavix) is activated by cytochrome p450 (p450) to a metabolite that inhibits ADP-induced platelet aggregation. Adenosine Diphosphate 102-105 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 60-64 12485953-1 2003 The prodrug clopidogrel (Plavix) is activated by cytochrome p450 (p450) to a metabolite that inhibits ADP-induced platelet aggregation. Adenosine Diphosphate 102-105 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 66-70 16857990-4 2006 At 10-microM concentrations, the 2 structurally distinct GIRK channel blockers, SCH23390 and U50488H, caused complete inhibition of ADP-induced cPLA2 phosphorylation and TXA2 generation, without affecting the conversion of AA to TXA2 or ADP-induced primary platelet aggregation in aspirin-treated platelets. Adenosine Diphosphate 132-135 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 144-149 14693172-7 2003 PAC-1 MFI decreased from 66+/-23 to 34+/-18 units (p<0.05) after ADP and from 74+/-29 to 42+/-17 units (p<0.05) after TRAP, respectively. Adenosine Diphosphate 68-71 dual specificity phosphatase 2 Homo sapiens 0-5 16817779-4 2006 HNP1 (human neutrophil protein 1) inhibited DT- or ETA-mediated ADP-ribosylation of eEF2 (eukaryotic elongation factor 2) and protected HeLa cells against DT- or ETA-induced cell death. Adenosine Diphosphate 64-67 endothelin receptor type A Homo sapiens 51-54 12492285-8 2002 In vitro replacement of vWF-deficient plasma with plasma from an unaffected dog shortened the ADP-CT whereas in vitro addition of DDAVP had no effect. Adenosine Diphosphate 94-97 von Willebrand factor Canis lupus familiaris 24-27 16962388-0 2006 The structure of the second cytosolic loop of the yeast mitochondrial ADP/ATP carrier AAC2 is dependent on the conformational state. Adenosine Diphosphate 70-73 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 86-90 12176987-7 2002 These results suggest that ATP binds to PMP70 tightly in the absence of Mg2+, the bound ATP is hydrolyzed to ADP in the presence of Mg2+, and the produced ADP is dissociated from PMP70, which allows ATP hydrolysis turnover. Adenosine Diphosphate 109-112 ATP binding cassette subfamily D member 3 Rattus norvegicus 40-45 12176987-7 2002 These results suggest that ATP binds to PMP70 tightly in the absence of Mg2+, the bound ATP is hydrolyzed to ADP in the presence of Mg2+, and the produced ADP is dissociated from PMP70, which allows ATP hydrolysis turnover. Adenosine Diphosphate 155-158 ATP binding cassette subfamily D member 3 Rattus norvegicus 40-45 12176987-7 2002 These results suggest that ATP binds to PMP70 tightly in the absence of Mg2+, the bound ATP is hydrolyzed to ADP in the presence of Mg2+, and the produced ADP is dissociated from PMP70, which allows ATP hydrolysis turnover. Adenosine Diphosphate 155-158 ATP binding cassette subfamily D member 3 Rattus norvegicus 179-184 16962388-1 2006 To detect structural changes in the second cytosolic loop of the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae AAC2, we prepared 20 single cysteine mutants by replacing each amino acid in the S213 to L232 region. Adenosine Diphosphate 79-82 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 123-127 16546113-4 2006 Utilizing an in vivo rat model data is provided indicating that preconditioning completely prevents cardiac ischemia/reperfusion-induced: (1) loss in the activity of the redox sensitive Krebs cycle enzyme alpha-ketoglutarate dehydrogenase; (2) declines in NADH-linked ADP-dependent mitochondrial respiration; (3) insertion of the pro-apoptotic Bcl-2 protein Bax into the mitochondrial membrane; and (4) release of cytochrome c into the cytosol. Adenosine Diphosphate 268-271 oxoglutarate dehydrogenase Rattus norvegicus 205-238 12119284-7 2002 In contrast, AMP and ADP passed about 8-fold better, and ATP greater than 300-fold better, through channels formed by Cx43. Adenosine Diphosphate 21-24 gap junction protein alpha 1 Homo sapiens 118-122 17060024-6 2006 In addition, the average mRNA expression of p56lck, p59fyn and zap-70 were all found to be dramatically higher in the mice immunized with only ADP/ATP carrier peptides than in the control-group. Adenosine Diphosphate 143-146 lymphocyte protein tyrosine kinase Mus musculus 44-50 12204118-4 2002 The FRETs for the myosin.ADP.AlF4- and myosin.ADP.BeFn ternary complexes, which mimic the M*.ADP.P(i) state and M.ATP state in the ATPase cycle, respectively, were similar to that of NBD-ATP. Adenosine Diphosphate 25-28 dynein axonemal heavy chain 8 Homo sapiens 131-137 17060025-12 2006 The frequency of HLA-DPB1*0601 allele was significantly higher in IDC patients with positive autoantibody against ADP/ATP carrier of myocardial mitochondria in contrast to those with negative autoantibody. Adenosine Diphosphate 114-117 major histocompatibility complex, class II, DP beta 1 Homo sapiens 17-25 12204118-5 2002 This suggests that both the SH1 and SH2 regions change their localized conformations to move closer to the ATPase site in the M*.ATP state and M**.ADP.P(i) state than in the M*.ADP state. Adenosine Diphosphate 147-150 dynein axonemal heavy chain 8 Homo sapiens 107-113 12204118-5 2002 This suggests that both the SH1 and SH2 regions change their localized conformations to move closer to the ATPase site in the M*.ATP state and M**.ADP.P(i) state than in the M*.ADP state. Adenosine Diphosphate 177-180 dynein axonemal heavy chain 8 Homo sapiens 107-113 16804093-5 2006 These results were paralleled in human platelets, in which PMA reduced subsequent ADP-induced P2Y1 and P2Y12 receptor signaling. Adenosine Diphosphate 82-85 purinergic receptor P2Y12 Homo sapiens 103-108 17066149-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y1 and P2Y12) plays a very important role in thrombogenesis. Adenosine Diphosphate 19-43 purinergic receptor P2Y12 Homo sapiens 88-93 12353080-0 2002 Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 114-119 17066149-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y1 and P2Y12) plays a very important role in thrombogenesis. Adenosine Diphosphate 45-48 purinergic receptor P2Y12 Homo sapiens 88-93 16943556-6 2006 We also suggest the involvement of myristoylated alanine-rich C kinase substrate (MARCKS), which is known as a downstream target of PKC-epsilon, in ADP of LDCV exocytosis. Adenosine Diphosphate 148-151 myristoylated alanine rich protein kinase C substrate Homo sapiens 35-80 12023879-3 2002 The lipolytic effect of noradrenaline was lowered by ectopic UCP1 in white adipocytes of aP2-Ucp1 transgenic mice, overexpressing the UCP1 gene from the aP2 gene promoter, reflecting the magnitude of UCP1 expression, the impaired stimulation of cAMP levels by noradrenaline and the reduction of the ATP/ADP ratio in different fat depots. Adenosine Diphosphate 303-306 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 61-65 16943556-6 2006 We also suggest the involvement of myristoylated alanine-rich C kinase substrate (MARCKS), which is known as a downstream target of PKC-epsilon, in ADP of LDCV exocytosis. Adenosine Diphosphate 148-151 myristoylated alanine rich protein kinase C substrate Homo sapiens 82-88 16943556-7 2006 The level of phospho-MARCKS correlated with the time course of ADP and was reduced by transfection with DN-PKC-epsilon. Adenosine Diphosphate 63-66 myristoylated alanine rich protein kinase C substrate Homo sapiens 21-27 16943556-9 2006 Furthermore, knockdown of MARCKS by siRNA resulted in inhibition of ADP and reduction of the number of fused vesicles. Adenosine Diphosphate 68-71 myristoylated alanine rich protein kinase C substrate Homo sapiens 26-32 16943556-10 2006 Together, we provide evidence that ADP of LDCV exocytosis is regulated by PKC-epsilon and its downstream target MARCKS via modulating vesicle translocation. Adenosine Diphosphate 35-38 myristoylated alanine rich protein kinase C substrate Homo sapiens 112-118 12022877-5 2002 PA containing bound MgADP supports elongation of the actin filament barbed end, indicating that ATP hydrolysis is not necessary for PA elongation of filaments. Adenosine Diphosphate 20-25 actin epsilon 1 Bos taurus 53-58 12222799-1 2002 The amount of protein synthesis translational elongation factor 2 (eEF-2) was estimated employing diphtheria toxin-dependent ADP-ribosylation in samples prepared from small amounts of tissue from mammary gland, skeletal muscle and liver from lactating dairy cows. Adenosine Diphosphate 125-128 eukaryotic translation elongation factor 2 Bos taurus 67-72 12222799-2 2002 A very high level of ADP-ribosylatable eEF-2 was found in mammary gland, amounting to 20-times the level found in liver and 50-times the level found in skeletal muscle. Adenosine Diphosphate 21-24 eukaryotic translation elongation factor 2 Bos taurus 39-44 12222799-5 2002 A close linear relationship was found between the amount of diphtheria-toxin catalysted ADP-ribosylated eEF-2 and protein and casein output in milk from cows in late lactation. Adenosine Diphosphate 88-91 eukaryotic translation elongation factor 2 Bos taurus 104-109 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 89-92 X-prolyl aminopeptidase 2 Homo sapiens 167-171 16257449-25 2006 The P2Y13-receptor is expressed in immunocytes and neuronal cells and is again activated by ADP and 2-methylthio-ADP. Adenosine Diphosphate 92-95 purinergic receptor P2Y13 Homo sapiens 4-9 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 145-148 X-prolyl aminopeptidase 2 Homo sapiens 167-171 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 145-148 X-prolyl aminopeptidase 2 Homo sapiens 167-171 11939802-5 2002 In addition, we demonstrate that efficient folding in the chaperonin cavity requires ATP hydrolysis, as formation of ternary GroEL/GroES complexes with substrate proteins in the presence of ADP results only in very inefficient reactivation. Adenosine Diphosphate 190-193 heat shock protein family E (Hsp10) member 1 Homo sapiens 131-136 16517984-3 2006 ATP, ADP, and pyruvate markedly quenched the tryptophan fluorescence of PDHK2 and gave maximum quenching/L0.5 estimates: approximately 53%/3 microM for ATP; approximately 49%/15 microM for ADP; and approximately 71%/approximately 590 microM for pyruvate. Adenosine Diphosphate 5-8 pyruvate dehydrogenase kinase 2 Homo sapiens 72-77 11841236-0 2002 Rhodanese can partially refold in its GroEL-GroES-ADP complex and can be released to give a homogeneous product. Adenosine Diphosphate 50-53 heat shock protein family E (Hsp10) member 1 Homo sapiens 44-49 16517984-3 2006 ATP, ADP, and pyruvate markedly quenched the tryptophan fluorescence of PDHK2 and gave maximum quenching/L0.5 estimates: approximately 53%/3 microM for ATP; approximately 49%/15 microM for ADP; and approximately 71%/approximately 590 microM for pyruvate. Adenosine Diphosphate 189-192 pyruvate dehydrogenase kinase 2 Homo sapiens 72-77 11841236-4 2002 Rhodanese partially folds while in the GroEL-GroES-ADP complex, but it does not significantly reach an active state. Adenosine Diphosphate 51-54 heat shock protein family E (Hsp10) member 1 Homo sapiens 45-50 11841236-5 2002 Partially folded rhodanese can be released from the GroEL-GroES-ADP complex by subdenaturing concentrations of urea as a homogeneous species that is committed to fold to the native conformation with little or no partitioning to the aggregated state. Adenosine Diphosphate 64-67 heat shock protein family E (Hsp10) member 1 Homo sapiens 58-63 16517984-7 2006 ADP-enhanced binding of pyruvate was maintained with W383F-PDHK2. Adenosine Diphosphate 0-3 pyruvate dehydrogenase kinase 2 Homo sapiens 59-64 16517984-11 2006 Binding of PDHK2 to GST-L2(red) was modestly hindered by 200 microM level of ATP or ADP or 5.0 mM pyruvate; a marked change to nearly complete prevention of binding was observed with ATP or ADP plus pyruvate at only 100 microM levels, and these conditions caused PDHK2 dimer to associate to a tetramer. Adenosine Diphosphate 84-87 pyruvate dehydrogenase kinase 2 Homo sapiens 11-16 16517984-12 2006 These changes should make major contributions to synergistic inhibition of PDHK2 activity by ADP and pyruvate. Adenosine Diphosphate 93-96 pyruvate dehydrogenase kinase 2 Homo sapiens 75-80 16630281-2 2006 The Klaac null mutation, which causes a respiratory-deficient phenotype, was fully complemented by AAC2, the Saccharomyces cerevisiae major gene for the ADP/ATP carrier and also by AAC1, a gene that is poorly expressed in S. cerevisiae. Adenosine Diphosphate 153-156 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 99-103 12008071-4 2002 ADP, but not UTP or adenosine, also stimulated the proliferation of retinal cells (EC(50)=5.8 microM), indicating that activation of P2Y1 receptors mediates the proliferative response of retinal cells to ATP. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Gallus gallus 133-137 16424148-7 2006 Inhibition of MMP-2 by phenantroline and degradation of ADP by APT102, respectively, resulted in inhibition of TCIPA. Adenosine Diphosphate 56-59 matrix metallopeptidase 2 Homo sapiens 14-19 11858493-5 2002 However, PAC-1 binding increased in both subpopulations after addition of ADP. Adenosine Diphosphate 74-77 dual specificity phosphatase 2 Homo sapiens 9-14 16600868-3 2006 Here we show that both subunits can simultaneously bind ATP and identify the Msh6 subunit as containing the high-affinity ATP binding site and Msh2 as containing a high-affinity ADP binding site. Adenosine Diphosphate 178-181 mutS homolog 2 Homo sapiens 143-147 11812157-9 2002 It is this weaker nucleating potential of ADF-actin.ADP that accounts for the much higher steady-state depolymerizing activity. Adenosine Diphosphate 52-55 destrin, actin depolymerizing factor Homo sapiens 42-45 16600868-4 2006 Stable binding of ATP to Msh6 causes decreased affinity of Msh2 for ADP, and binding to mispaired DNA stabilized the binding of ATP to Msh6. Adenosine Diphosphate 68-71 mutS homolog 2 Homo sapiens 59-63 16634757-1 2006 Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 175-180 16634757-1 2006 Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 175-180 16497986-3 2006 We demonstrate that extracellular nucleotides (ATP, ADP, and UTP, but not UDP) and adenosine independently induce phosphorylation and activation of AMPK in human umbilical vein EC (HUVEC) by the mechanism that is not linked to changes in AMP:ATP ratio. Adenosine Diphosphate 52-55 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 148-152 16373383-4 2006 In this study, we investigated the relationship between channel regulation by SUR1 and PIP2 by comparing a number of single and double mutants known to affect open probability (P(o)), PIP2 affinity, and sulphonylurea and MgADP sensitivity. Adenosine Diphosphate 221-226 ATP binding cassette subfamily C member 8 Homo sapiens 78-82 16373383-9 2006 In conjunction with this PIP2-dependent process, SUR1 also regulates channel activity via a PIP2-independent, but MgADP-dependent process. Adenosine Diphosphate 114-119 ATP binding cassette subfamily C member 8 Homo sapiens 49-53 16507998-4 2006 The inhibition of ADP/ATP exchange coincided with the loss of interaction between ANT and cyclophilin D and the inability of ANT to adopt the cytosolic conformational state, which prevented cytochrome c release. Adenosine Diphosphate 18-21 peptidylprolyl isomerase D Homo sapiens 90-103 15927298-13 2005 The results indicate that leptin enhances ADP-induced [Ca(2+)](i) increases via JAK2 and tyrosine kinases in a megakaryoblast cell line. Adenosine Diphosphate 42-45 Janus kinase 2 Homo sapiens 80-84 16082692-6 2005 Here, we report results demonstrating a significant linkage peak for ADP on 8p12 in the NIMH AD dataset, encompassing the NRG1 region. Adenosine Diphosphate 69-72 neuregulin 1 Homo sapiens 122-126 16082692-7 2005 We also demonstrate that there is a significant association with a NRG1 SNP (single nucleotide polymorphism), rs392499, with ADP, chi2 = 7.0, P = 0.008. Adenosine Diphosphate 125-128 neuregulin 1 Homo sapiens 67-71 16115812-8 2005 Thus, the polyglutamine tract in huntingtin appears to regulate mitochondrial ADP-phosphorylation in a Ca2+-dependent process that fulfills the genetic criteria for the HD trigger of pathogenesis, and it thereby determines a fundamental biological parameter--cellular energy status, which may contribute to the exquisite vulnerability of striatal neurons in HD. Adenosine Diphosphate 78-81 huntingtin Homo sapiens 33-43 16055438-4 2005 By using steady-state and transient kinetic methods, we showed that myosin VIIB exhibits a fast release of phosphate and a slower, rate-limiting ADP release from actomyosin. Adenosine Diphosphate 145-148 Myosin 28B1 Drosophila melanogaster 68-79 15893323-4 2005 K(ATP) channels generated from coexpression of Kir6.2 with SUR1 exhibit greater MgADP stimulation than channels generated from coexpression of Kir6.2 with SUR2A. Adenosine Diphosphate 80-85 ATP binding cassette subfamily C member 8 Homo sapiens 59-63 15893323-7 2005 This biochemical difference may underlie the increased MgADP stimulation exhibited by SUR1-containing channels vs. SUR2A-containing channels, which may in turn contribute to physiological differences, observed at the tissue level, between pancreatic and cardiac K(ATP) channels. Adenosine Diphosphate 55-60 ATP binding cassette subfamily C member 8 Homo sapiens 86-90 15817818-6 2005 RESULTS: Aggregometry and VASP phosphorylation revealed a loss of platelet response to ADP within 12 h after clopidogrel intake. Adenosine Diphosphate 87-90 vasodilator stimulated phosphoprotein Homo sapiens 26-30 15968398-3 2005 In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets. Adenosine Diphosphate 262-283 syndecan 4 Homo sapiens 48-58 15968398-5 2005 We further observed that antithrombin limits CD40 ligand expression in adenosine diphosphate-activated platelets and inhibits the shedding of syndecan-4 from activated platelets. Adenosine Diphosphate 71-92 CD40 molecule Homo sapiens 45-49 15861126-4 2005 Here, we present crystal structures of the PDK3-L2 complex with and without bound ADP or ATP. Adenosine Diphosphate 82-85 pyruvate dehydrogenase kinase 3 Homo sapiens 43-47 11880175-6 2002 The inhibition constants for the inhibition of CDK4 by MgADP and a small molecule inhibitor were also perturbed by Mg(2+). Adenosine Diphosphate 55-60 cyclin dependent kinase 4 Homo sapiens 47-51 11880175-7 2002 K(d(a)) values estimated from the metal variation of the inhibition of CDK4 by MgADP (6+/-3 mM) and a small molecule inhibitor (3+/-1 mM), were in good agreement with the K(d(a)) value (5+/-1 mM) obtained from the metal variation of the initial rate of CDK4. Adenosine Diphosphate 79-84 cyclin dependent kinase 4 Homo sapiens 71-75 11880175-7 2002 K(d(a)) values estimated from the metal variation of the inhibition of CDK4 by MgADP (6+/-3 mM) and a small molecule inhibitor (3+/-1 mM), were in good agreement with the K(d(a)) value (5+/-1 mM) obtained from the metal variation of the initial rate of CDK4. Adenosine Diphosphate 79-84 cyclin dependent kinase 4 Homo sapiens 253-257 12841327-5 2002 Fe2+/ADP and 2,2,-azobis-(2-amidinopropane) dihydrochloride (AAPH) induced swelling of mitochondria and the release of Ca2+ and Cyt.c were not coupled with depolarization or CsA-sensitivity while dibucaine-induced swelling occurred without depolarization, Cyt.c-release or by a CsA-sensitive mechanism. Adenosine Diphosphate 5-8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 174-177 12841327-5 2002 Fe2+/ADP and 2,2,-azobis-(2-amidinopropane) dihydrochloride (AAPH) induced swelling of mitochondria and the release of Ca2+ and Cyt.c were not coupled with depolarization or CsA-sensitivity while dibucaine-induced swelling occurred without depolarization, Cyt.c-release or by a CsA-sensitive mechanism. Adenosine Diphosphate 5-8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 278-281 15861126-6 2005 The two swapped C-terminal tails promote conformational changes in active-site clefts of both PDK3 subunits, resulting in largely disordered ATP lids in the ADP-bound form. Adenosine Diphosphate 157-160 pyruvate dehydrogenase kinase 3 Homo sapiens 94-98 15861126-7 2005 Our structural and biochemical data suggest that L2 binding stimulates PDK3 activity by disrupting the ATP lid, which otherwise traps ADP, to remove product inhibition exerted by this nucleotide. Adenosine Diphosphate 134-137 pyruvate dehydrogenase kinase 3 Homo sapiens 71-75 11546776-3 2001 GPR86 proved to be a G(i)-coupled receptor displaying a high affinity for ADP, similar to the P2Y(12) receptor and can therefore be tentatively called P2Y(13). Adenosine Diphosphate 74-77 purinergic receptor P2Y13 Homo sapiens 0-5 11546776-3 2001 GPR86 proved to be a G(i)-coupled receptor displaying a high affinity for ADP, similar to the P2Y(12) receptor and can therefore be tentatively called P2Y(13). Adenosine Diphosphate 74-77 purinergic receptor P2Y13 Homo sapiens 151-158 15665114-0 2005 P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Adenosine Diphosphate 29-32 purinergic receptor P2Y12 Homo sapiens 9-14 11546776-9 2001 Although these can be discriminated by tissue distribution and some pharmacological features, the P2Y(12) and P2Y(13) receptors form a subgroup of related P2Y subtypes that is structurally different from the other P2Y subtypes but share coupling to G(i) and a high affinity for ADP. Adenosine Diphosphate 278-281 purinergic receptor P2Y13 Homo sapiens 110-117 15731382-0 2005 Use of helper enzymes for ADP removal in infrared spectroscopic experiments: application to Ca2+-ATPase. Adenosine Diphosphate 26-29 dynein axonemal heavy chain 8 Homo sapiens 97-103 15869601-0 2005 Lipid rafts are required in Galpha(i) signaling downstream of the P2Y12 receptor during ADP-mediated platelet activation. Adenosine Diphosphate 88-91 purinergic receptor P2Y12 Homo sapiens 66-71 11592941-8 2001 The more relatively selective P2X agonists [beta,gamma-methylene ATP (beta,gamma-Me-ATP) and 2"- and -3"-O-(4-benzoyl-benzoyl)-ATP] inhibited arginine vasopressin (AVP)- and parathyroid hormone (PTH)-mediated Mg(2+) uptake whereas agonists more selective for P2Y purinoceptors (UTP, ADP, and 2-methylthio-ATP) were without effect. Adenosine Diphosphate 283-286 purinergic receptor P2X, ligand-gated ion channel, 1 Mus musculus 30-33 15869601-3 2005 We sought to determine the importance of lipid rafts in ADP-mediated platelet activation via the G protein-coupled P2Y1 and P2Y12 receptors using lipid raft disruption by cholesterol depletion with methyl-beta-cyclodextrin. Adenosine Diphosphate 56-59 purinergic receptor P2Y12 Homo sapiens 124-129 11585851-4 2001 These results suggest that R176 and R177 are required for functional coupling to SUR1, which confers MgADP and sulfonylurea sensitivity to the K(ATP) channel. Adenosine Diphosphate 101-106 ATP binding cassette subfamily C member 8 Homo sapiens 81-85 11585851-7 2001 This interaction is facilitated by binding of MgADP to NBF2 and blocked by binding of sulfonylureas to SUR1. Adenosine Diphosphate 46-51 ATP binding cassette subfamily C member 8 Homo sapiens 103-107 15823050-12 2005 In this work, an intermediate analogue containing an aldehyde functionality at C-6" ", ADP-beta-d-manno-hexodialdose, is prepared in order to probe the ability of the enzyme to catalyze redox chemistry at this position. Adenosine Diphosphate 87-90 complement C6 Homo sapiens 79-82 11560562-10 2001 Inhibition of ADP-and collagen-induced aggregation tended to be attenuated by treatment with UFH (e.g. ADP-induced aggregation at 0.25 h after ABC + ASA alone =13 +/- 4%; after coadministration with UFH = 40 +/- 26%). Adenosine Diphosphate 103-106 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 143-146 11560568-6 2001 The mean difference (95% CI) for ADP-induced PAC-1 binding (fluorescence intensity) between baseline and 7 days after the last dose was 0.01 (0.61, -0.59). Adenosine Diphosphate 33-36 dual specificity phosphatase 2 Homo sapiens 45-50 11699950-4 2001 Also, the rate of adenosine formation increased sharply when the extracellular concentrations of ATP + ADP decrease below 5 microM, indicating that ATP/ADP feed-forwardly inhibit ecto-5"-nucleotidase allowing a burst-like formation of adenosine possibly designed to activate facilitatory A2A receptors. Adenosine Diphosphate 103-106 5' nucleotidase, ecto Rattus norvegicus 179-199 11699950-5 2001 Initial rate measurements of ecto-5"-nucleotidase in hippocampal nerve terminals, using IMP as substrate, showed that ATP and ADP are competitive inhibitors (apparent Ki of 14 and 4 microM). Adenosine Diphosphate 126-129 5' nucleotidase, ecto Rattus norvegicus 29-49 15795539-3 2005 The aim of this study was to test in patients (n = 416) scheduled for coronary artery stenting whether P2Y12 haplotype H2 carriage is associated with increased ADP-induced platelet aggregation after administration of a 600 mg loading dose of clopidogrel. Adenosine Diphosphate 160-163 purinergic receptor P2Y12 Homo sapiens 103-108 11423557-5 2001 At physiological nucleotide concentrations, myosin VI is strongly bound to actin and populates the nucleotide-free (rigor) and ADP-bound states. Adenosine Diphosphate 127-130 myosin VI Homo sapiens 44-53 15960075-5 2005 ADP-induced increases in PAC-1 binding were significantly enhanced by exposing the platelets to concentrations of either 20% or 40% HbV, whereas the ADP-induced increases in CD62P expression were not affected by HbV treatment at either concentration. Adenosine Diphosphate 0-3 dual specificity phosphatase 2 Homo sapiens 25-30 11384977-1 2001 The low-level expression of the bovine heart mitochondrial ADP/ATP carrier (bovine type 1 ADP/ATP carrier (bAAC1)) in the yeast mitochondrial membrane is significantly improved by replacement of its N-terminal region with corresponding regions of the yeast type 1 and 2 carriers (yAAC1 and yAAC2) (Hashimoto, M., Shinohara, Y., Majima, E., Hatanaka, T., Yamazaki, N., and Terada, H. (1999) Biochim. Adenosine Diphosphate 59-62 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 290-295 11384977-1 2001 The low-level expression of the bovine heart mitochondrial ADP/ATP carrier (bovine type 1 ADP/ATP carrier (bAAC1)) in the yeast mitochondrial membrane is significantly improved by replacement of its N-terminal region with corresponding regions of the yeast type 1 and 2 carriers (yAAC1 and yAAC2) (Hashimoto, M., Shinohara, Y., Majima, E., Hatanaka, T., Yamazaki, N., and Terada, H. (1999) Biochim. Adenosine Diphosphate 90-93 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 290-295 15345752-1 2004 ADP is the cognate agonist of the P2Y1, P2Y12, and P2Y13 receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 40-45 11396984-9 2001 The calculated free ADP response to ATPase decreased \2-fold in the presence of Ca(2+). Adenosine Diphosphate 20-23 dynein axonemal heavy chain 8 Homo sapiens 36-42 15345752-1 2004 ADP is the cognate agonist of the P2Y1, P2Y12, and P2Y13 receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 51-56 11396984-11 2001 The addition of Ca(2+) and ATPase combined increased the mitochondrial ATP production rate with changes in deltapsi, NADH and [ADP], consistent with an activation of CaDH and F o /F(1)ATPase activity. Adenosine Diphosphate 127-130 dynein axonemal heavy chain 8 Homo sapiens 27-33 15308557-1 2004 OBJECTIVE: ADP plays an important role in platelet aggregation by activating P2Y12 receptors. Adenosine Diphosphate 11-14 purinergic receptor P2Y12 Homo sapiens 77-82 11121414-4 2001 We found that NSP2 exists as an octamer, which is functional in the binding of RNA and ADP. Adenosine Diphosphate 87-90 reticulon 2 Homo sapiens 14-18 15308557-8 2004 The contraction was not reduced in patients using clopidogrel, a drug inhibiting ADP-induced platelet aggregation by blocking the P2Y12 receptor. Adenosine Diphosphate 81-84 purinergic receptor P2Y12 Homo sapiens 130-135 15308557-10 2004 CONCLUSIONS: ADP acting on P2Y12 receptors not only is important for platelet activation but also stimulates vasoconstriction. Adenosine Diphosphate 13-16 purinergic receptor P2Y12 Homo sapiens 27-32 15231825-5 2004 The release of sPLA(2) from mitochondria decreases when mitochondria are incubated in the presence of respiratory substrates such as ADP, malate, and pyruvate, which causes an increase of transmembrane potential determined by cytofluorimetric analysis using DiOC(6)(3) as a probe. Adenosine Diphosphate 133-136 phospholipase A2 group IIA Rattus norvegicus 15-22 11237858-13 2001 The inclusion of CaADP within the initiating cross-bridge and replacement by MgADP during the second cycle is consistent with the observed fall in the rate of the myofibril ATPase that occurs after two phosphates are released. Adenosine Diphosphate 77-82 dynein axonemal heavy chain 8 Homo sapiens 173-179 15323562-2 2004 Here we report the preparation of the isolated flavin mononucleotide (FMN)-binding domain of nNOS with bound CaM and the electrochemical analysis of this and the isolated flavin adenine dinucleotide (FAD)-binding domain in the presence and absence of NADP(+) and ADP (an inhibitor). Adenosine Diphosphate 252-255 nitric oxide synthase 1 Homo sapiens 93-97 11172816-1 2001 The ability of the chemokines SDF-1, MDC and TARC to induce platelet aggregation depends strongly on low levels of ADP. Adenosine Diphosphate 115-118 C-X-C motif chemokine ligand 12 Homo sapiens 30-35 11172816-1 2001 The ability of the chemokines SDF-1, MDC and TARC to induce platelet aggregation depends strongly on low levels of ADP. Adenosine Diphosphate 115-118 C-C motif chemokine ligand 22 Homo sapiens 37-40 11172816-1 2001 The ability of the chemokines SDF-1, MDC and TARC to induce platelet aggregation depends strongly on low levels of ADP. Adenosine Diphosphate 115-118 C-C motif chemokine ligand 17 Homo sapiens 45-49 15265806-0 2004 Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation. Adenosine Diphosphate 74-77 purinergic receptor P2Y12 Homo sapiens 41-46 15265806-0 2004 Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation. Adenosine Diphosphate 74-77 purinergic receptor P2Y12 Homo sapiens 56-61 11018047-7 2000 These data suggest that there is a second step (ADP release) in the smooth muscle myosin-actin-activated ATPase cycle that is modulated by regulatory light chain phosphorylation. Adenosine Diphosphate 48-51 dynein axonemal heavy chain 8 Homo sapiens 105-111 15123651-0 2004 hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. Adenosine Diphosphate 16-19 X-ray repair cross complementing 2 Homo sapiens 0-6 11071639-2 2000 Recently, adenosine diphosphate (ADP) has been shown to play a major role in platelet activation and aggregation induced by FcgammaRIIA cross-linking or by sera from HIT patients. Adenosine Diphosphate 10-31 Fc gamma receptor IIa Homo sapiens 124-135 15213852-10 2004 Stimulating the Gq-coupled TXA2 -receptor with U46619 (10 microM), which leads to ADP secretion and P2Y12 receptor-dependent platelet aggregation, also induces P2Y12-related ERK2 activation. Adenosine Diphosphate 82-85 purinergic receptor P2Y12 Homo sapiens 160-165 11071639-2 2000 Recently, adenosine diphosphate (ADP) has been shown to play a major role in platelet activation and aggregation induced by FcgammaRIIA cross-linking or by sera from HIT patients. Adenosine Diphosphate 33-36 Fc gamma receptor IIa Homo sapiens 124-135 11071639-3 2000 Herein, we investigated the mechanism of action of ADP as a cofactor in FcgammaRIIA-dependent platelet activation, which is classically known to involve tyrosine kinases. Adenosine Diphosphate 51-54 Fc gamma receptor IIa Homo sapiens 72-83 11071639-7 2000 Conversely, the Gi-dependent signaling pathway, initiated either by ADP or epinephrine, was required for FcgammaRIIA-mediated phospholipase C activation and calcium mobilization. Adenosine Diphosphate 68-71 Fc gamma receptor IIa Homo sapiens 105-116 11011142-2 2000 Without an added ADP-ribose acceptor, Rt6.2 shows NAD glycohydrolase (NADase) activity. Adenosine Diphosphate 17-20 ADP-ribosyltransferase 2a Mus musculus 38-41 10960076-9 2000 ATP stimulates P2X(1) receptors, whereas ADP is a selective agonist at metabotropic (P2Y(1) and P2T(AC)) receptors. Adenosine Diphosphate 41-44 purinergic receptor P2Y12 Homo sapiens 96-103 15184020-5 2004 The K(d) values for ADP-binding to wild-type ORC and to ORC-1A (ORC containing Orc1p with a defective Walker A motif) were less than 10nM, showing that Orc5p can bind to ADP with a high affinity, similar to ATP. Adenosine Diphosphate 20-23 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 79-84 11078025-4 2000 Complete homogeneity (approximately 100% fast) was observed when cytochrome c oxidase was solubilized with ultra-pure cholate from heart mitochondrial particles pre-equilibrated with AMP; equilibration with ADP yielded a much smaller fraction of fast enzyme (approximately 35%). Adenosine Diphosphate 207-210 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 65-85 15184020-6 2004 ORC-5A (ORC containing Orc5p with a defective Walker A motif) did not bind to ADP, suggesting that the ADP-Orc1p complex is too unstable to be detected by the filter-binding assay. Adenosine Diphosphate 103-106 origin recognition complex subunit 1 Saccharomyces cerevisiae S288C 107-112 15182175-3 2004 The steady-state ATP hydrolysis rate is equivalent to the rate of ADP release from the high-affinity site under a number of conditions, indicating that this process is the rate-limiting step in the ATPase cycle of the free enzyme. Adenosine Diphosphate 66-69 dynein axonemal heavy chain 8 Homo sapiens 198-204 10924134-1 2000 Metal ligands of the VO(2+)-adenosine diphosphate (ADP) complex bound to high-affinity catalytic site 1 of chloroplast F(1) adenosine triphosphatase (CF(1) ATPase) were characterized by electron paramagnetic resonance (EPR) spectroscopy. Adenosine Diphosphate 51-54 dynein axonemal heavy chain 8 Homo sapiens 156-162 15182175-4 2004 Because efficient protein translocation requires at least a 100-fold acceleration in the ATPase rate, the rate-limiting process of ADP release from the high-affinity site is likely to play a controlling role in the conformational reaction cycle of SecA. Adenosine Diphosphate 131-134 dynein axonemal heavy chain 8 Homo sapiens 89-95 15078882-6 2004 We found that activation of Rap1B by selected doses of agonists able to elicit comparable intracellular Ca(2+) increase and serotonin release was differently dependent on secreted ADP. Adenosine Diphosphate 180-183 RAP1B, member of RAS oncogene family Homo sapiens 28-33 10891361-2 2000 First, RhoA was identified by immunostaining and ADP-ribosylation in germinal vesicle (GV) stage-oocytes. Adenosine Diphosphate 49-52 ras homolog family member A Mus musculus 7-11 15078882-7 2004 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase, activation of Rap1B induced by stimulation of either PAR-1 or PAR-4 was totally inhibited. Adenosine Diphosphate 23-26 RAP1B, member of RAS oncogene family Homo sapiens 103-108 15078882-8 2004 By contrast, thrombin-induced activation of Rap1B was only minimally affected by neutralization of secreted ADP. Adenosine Diphosphate 108-111 RAP1B, member of RAS oncogene family Homo sapiens 44-49 15078882-9 2004 Concomitant stimulation of both PAR-1 and PAR-4 in the presence of ADP scavengers still resulted in a strongly reduced activation of Rap1B. Adenosine Diphosphate 67-70 RAP1B, member of RAS oncogene family Homo sapiens 133-138 15078882-11 2004 Activation of Rap1B induced by thrombin was not affected by preincubation of platelets with the anti-GPIbalpha monoclonal antibody AK2 in the absence of ADP scavengers or a P2Y12 antagonist but was totally abolished when secreted ADP was neutralized or after blockade of the P2Y12 receptor. Adenosine Diphosphate 230-233 RAP1B, member of RAS oncogene family Homo sapiens 14-19 15203713-9 2004 We conclude that ADP released from red blood cells enhances PMP formation induced by collagen, and that both P2Y12 and P2Y1 contribute to ADP-potentiation of PMP generation induced by collagen. Adenosine Diphosphate 138-141 purinergic receptor P2Y12 Homo sapiens 109-114 11798806-5 2000 That monoclonal antibody of the FIB-R combined with ADP activating platelets was inhibited by synthetic peptide (RGDS). Adenosine Diphosphate 52-55 ral guanine nucleotide dissociation stimulator Homo sapiens 113-117 10751543-5 2000 This conclusion is supported by results showing that both ADP antagonists and ADPase can inhibit the effect of plasmin on platelets. Adenosine Diphosphate 58-61 plasminogen Homo sapiens 111-118 15136046-1 2004 DnaK, the prokaryotic Hsp70 molecular chaperone, requires the nucleotide exchange factor and heat shock protein GrpE to release ADP. Adenosine Diphosphate 128-131 GrpE like 1, mitochondrial Homo sapiens 112-116 10751543-6 2000 We also demonstrated that pretreatment of platelets with ADP makes the platelets more sensitive to plasmin, and plasmin-induced platelet aggregation is, therefore, observed at lower concentrations where no aggregation occurs in quiescent platelets. Adenosine Diphosphate 57-60 plasminogen Homo sapiens 99-106 10751543-7 2000 In other words, it is thought that ADP potentiates the plasmin-induced aggregation. Adenosine Diphosphate 35-38 plasminogen Homo sapiens 55-62 10751543-10 2000 These data indicate that ADP potentiates plasmin-induced platelet aggregation via the P2T(AC) receptor. Adenosine Diphosphate 25-28 plasminogen Homo sapiens 41-48 10751543-10 2000 These data indicate that ADP potentiates plasmin-induced platelet aggregation via the P2T(AC) receptor. Adenosine Diphosphate 25-28 purinergic receptor P2Y12 Homo sapiens 86-93 10751543-11 2000 In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner. Adenosine Diphosphate 245-248 plasminogen Homo sapiens 89-96 10751543-11 2000 In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner. Adenosine Diphosphate 245-248 plasminogen Homo sapiens 207-214 15136046-3 2004 GrpE reduces the affinity of DnaK for ADP, and the reciprocal linkage is also true: ADP reduces the affinity of DnaK for GrpE. Adenosine Diphosphate 38-41 GrpE like 1, mitochondrial Homo sapiens 0-4 10751543-11 2000 In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner. Adenosine Diphosphate 245-248 plasminogen Homo sapiens 207-214 15136046-3 2004 GrpE reduces the affinity of DnaK for ADP, and the reciprocal linkage is also true: ADP reduces the affinity of DnaK for GrpE. Adenosine Diphosphate 38-41 GrpE like 1, mitochondrial Homo sapiens 121-125 10934601-2 2000 The EC50 values of ADP, inducing the activation and aggregation of thrombocytes, reflect the sequence of the agonist action on various receptors: P2X1, 20-40 nM; P2Y1, 90-110 nM; P2YADP, 120-240 nM. Adenosine Diphosphate 19-22 purinergic receptor P2X 1 Rattus norvegicus 146-150 10934601-3 2000 It was demonstrated that ADP behaves as partial agonist not only with respect to P2X1 receptors, but with respect to P2Y1 receptors as well. Adenosine Diphosphate 25-28 purinergic receptor P2X 1 Rattus norvegicus 81-85 15136046-3 2004 GrpE reduces the affinity of DnaK for ADP, and the reciprocal linkage is also true: ADP reduces the affinity of DnaK for GrpE. Adenosine Diphosphate 84-87 GrpE like 1, mitochondrial Homo sapiens 0-4 15136046-3 2004 GrpE reduces the affinity of DnaK for ADP, and the reciprocal linkage is also true: ADP reduces the affinity of DnaK for GrpE. Adenosine Diphosphate 84-87 GrpE like 1, mitochondrial Homo sapiens 121-125 15136046-5 2004 Sedimentation velocity (SV) analytical ultracentrifugation (AUC) was used to measure the equilibrium constants (Keq) for GrpE binding to the ATPase domain of DnaK in the presence of ADP. Adenosine Diphosphate 182-185 GrpE like 1, mitochondrial Homo sapiens 121-125 15136046-6 2004 ADP-bound DnaK is the natural target of GrpE, and the addition of ADP (final concentration of 5 microM) to the preformed GrpE-DnaK(ATPase) complexes allowed the equilibrium association constants to be brought into an experimentally accessible range. Adenosine Diphosphate 0-3 GrpE like 1, mitochondrial Homo sapiens 40-44 15136046-6 2004 ADP-bound DnaK is the natural target of GrpE, and the addition of ADP (final concentration of 5 microM) to the preformed GrpE-DnaK(ATPase) complexes allowed the equilibrium association constants to be brought into an experimentally accessible range. Adenosine Diphosphate 0-3 GrpE like 1, mitochondrial Homo sapiens 121-125 15136046-6 2004 ADP-bound DnaK is the natural target of GrpE, and the addition of ADP (final concentration of 5 microM) to the preformed GrpE-DnaK(ATPase) complexes allowed the equilibrium association constants to be brought into an experimentally accessible range. Adenosine Diphosphate 66-69 GrpE like 1, mitochondrial Homo sapiens 40-44 15136046-6 2004 ADP-bound DnaK is the natural target of GrpE, and the addition of ADP (final concentration of 5 microM) to the preformed GrpE-DnaK(ATPase) complexes allowed the equilibrium association constants to be brought into an experimentally accessible range. Adenosine Diphosphate 66-69 GrpE like 1, mitochondrial Homo sapiens 121-125 15129165-5 2004 These results suggest that ATP released from LPS-activated microglia and/or a metabolite of ATP (ADP) may induce IL-10 expression through P2Y purinergic receptors. Adenosine Diphosphate 97-100 ATPase phospholipid transporting 8A2 Homo sapiens 92-95 14707124-6 2004 Importantly, both mutant channels rescued to the cell surface have normal ATP, MgADP, and diazoxide sensitivities, demonstrating that SUR1 harboring either the A116P or the V187D mutation is capable of associating with Kir6.2 to form functional K(ATP) channels. Adenosine Diphosphate 79-84 ATP binding cassette subfamily C member 8 Homo sapiens 134-138 14993667-2 2004 Here, binary complex structures of full-length TPK I/GSK3 beta with the ATP analogues ADP and AMPPNP solved by the X-ray diffraction method at 2.1 and 1.8 A resolution, respectively, are reported. Adenosine Diphosphate 86-89 glycogen synthase kinase 3 beta Homo sapiens 53-62 14993667-6 2004 The overall structure and substrate-binding residues are similar to those observed in other Ser/Thr protein kinases, while Arg141 (which is not conserved among other Ser/Thr protein kinases) is one of the key residues for specific ATP/ADP recognition by TPK I/GSK3 beta. Adenosine Diphosphate 235-238 glycogen synthase kinase 3 beta Homo sapiens 260-269 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 interferon induced protein 44 Homo sapiens 67-70 14698287-6 2004 The slight changes in fluorescence caused by ATP and ADP suggest that the subunit-subunit contact is altered, leading to the elongation of the filament by these nucleotides, as with the RecA filament. Adenosine Diphosphate 53-56 RAD51 recombinase S homeolog Xenopus laevis 186-190 14706855-7 2004 By contrast, U46619 (10 microM), a stable analog of TXA(2), induced ERK2 activation in an ADP-dependent manner, via the P2Y12 receptor. Adenosine Diphosphate 90-93 purinergic receptor P2Y12 Homo sapiens 120-125 14670370-0 2004 Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1. Adenosine Diphosphate 14-17 purinergic receptor P2Y12 Homo sapiens 87-92 14688327-2 2004 By coimmunoprecipitation, we found that MBP is associated with hsp70 in APC in an ATP/ADP-dependent manner. Adenosine Diphosphate 86-89 myelin basic protein Homo sapiens 40-43 15262482-10 2004 Flow cytometry revealed that the expressions of CD11b and CD35 on neutrophils were increased by PRPr, but not by ATP and ADP. Adenosine Diphosphate 121-124 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 58-62 20021115-1 2004 Studies of fibroblasts with primary defects in mitochondrial ATP synthase (ATPase) due to heteroplasmic mtDNA mutations in the ATP6 gene, affecting protonophoric function or synthesis of subunit a, show that at high mutation loads, mitochondrial membrane potential DeltaPsi(m) at state 4 is normal, but ADP-induced discharge of DeltaPsi(m) is impaired and ATP synthesis at state 3-ADP is decreased. Adenosine Diphosphate 303-306 mitochondrially encoded ATP synthase 6 Homo sapiens 127-131 20021115-1 2004 Studies of fibroblasts with primary defects in mitochondrial ATP synthase (ATPase) due to heteroplasmic mtDNA mutations in the ATP6 gene, affecting protonophoric function or synthesis of subunit a, show that at high mutation loads, mitochondrial membrane potential DeltaPsi(m) at state 4 is normal, but ADP-induced discharge of DeltaPsi(m) is impaired and ATP synthesis at state 3-ADP is decreased. Adenosine Diphosphate 381-384 mitochondrially encoded ATP synthase 6 Homo sapiens 127-131 14659072-10 2003 The catalytic activities of the recombinant GDH enzymes were inhibited by ATP in a concentration-dependent manner over the range of 10 - 100 microM, whereas, ADP increased the enzyme activity up to 2.3-fold. Adenosine Diphosphate 158-161 glutamate dehydrogenase 1, mitochondrial Bos taurus 44-47 14596914-4 2003 Here we demonstrate an interaction of these two proteins resulting in ADP-ribosylation of the WRN protein. Adenosine Diphosphate 70-73 WRN RecQ like helicase Homo sapiens 94-97 14529283-4 2003 Consistent with the enzyme expressed in mammalian cells, this recombinant NTPDase6 efficiently hydrolyzes GDP, IDP, and UDP (specific activity of approximately 50000 micromol mg(-1) h(-1)), with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. Adenosine Diphosphate 236-239 cut like homeobox 1 Homo sapiens 216-219 12974724-8 2003 Percentage of CD62-positive monocytes (CD14+ particles) increased from baseline 5% to 13 +/- 6% in ADP-stimulated samples to 53 +/- 17% after isolation (P < 0.001). Adenosine Diphosphate 99-102 CD14 molecule Homo sapiens 39-43 14517228-7 2003 Surprisingly, when this structure was compared with that of the previously determined GroEL-GroES-ADP complex, no other differences were observed. Adenosine Diphosphate 98-101 heat shock protein family E (Hsp10) member 1 Homo sapiens 92-97 10715114-14 2000 Moreover, binding of VCP, which is an ATPase, to synaptotagmin I was inhibited by both ATP and ADP, indicating that the native, nucleotide-occupied state of VCP does not bind to synaptotagmin. Adenosine Diphosphate 95-98 valosin containing protein Homo sapiens 21-24 10715114-14 2000 Moreover, binding of VCP, which is an ATPase, to synaptotagmin I was inhibited by both ATP and ADP, indicating that the native, nucleotide-occupied state of VCP does not bind to synaptotagmin. Adenosine Diphosphate 95-98 synaptotagmin 1 Homo sapiens 49-64 14511112-6 2003 BzATP, a potent P2X7 receptor agonist, was more effective than ATP, ADP, or 2-MeSATP at enhancing IFN gamma-induced ERK1/2 phosphorylation. Adenosine Diphosphate 68-71 mitogen-activated protein kinase 3 Mus musculus 116-122 10666039-9 2000 Ca(2+) increased the ADP arsenylation rate more than twofold, suggesting a direct effect on the F(0)/F(1)-ATPase. Adenosine Diphosphate 21-24 ATP synthase F1 subunit epsilon Homo sapiens 96-112 10592661-3 2000 The elucidation of the atomic structure of the HCV NS3 helicase in complex with oligonucleotide and with ADP has helped clarify our understanding of potential sites for inhibitor binding. Adenosine Diphosphate 105-108 helicase for meiosis 1 Homo sapiens 55-63 12972261-0 2003 Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. Adenosine Diphosphate 102-105 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 79-85 10615958-13 2000 There is a cooperative regulation of ATP and ADP binding to SUR1, and this cooperativity may be involved in regulating the K(ATP) channel. Adenosine Diphosphate 45-48 ATP binding cassette subfamily C member 8 Homo sapiens 60-64 12972261-5 2003 We also determined an X-ray structure at 2.0A resolution of the variant NDPK-A in complex with ADP, Ca(2+) and inorganic phosphate, products of ATP hydrolysis. Adenosine Diphosphate 95-98 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 72-78 12963378-9 2003 All three proteins bound nucleotide as effectively as did GroEL, but the binding of GroES in the presence of ATP or ADP was reduced significantly relative to the wild-type. Adenosine Diphosphate 116-119 heat shock protein family E (Hsp10) member 1 Homo sapiens 84-89 10833799-12 2000 CONCLUSIONS: The morning rise of systolic BP is associated with an increase of ADP-induced and spontaneous platelet aggregability in the patients with mild to moderate essential hypertension and apparently that association is more pronounced at high values of morning BP (more than 20% from mean nocturnal values of SBP). Adenosine Diphosphate 79-82 selenium binding protein 1 Homo sapiens 316-319 12816949-9 2003 ATP and ADP decreased the affinity of PDK2 for E2 by 3-5-fold and adenosine 5"-(beta,gamma-imino)triphosphate or phosphorylation of E1 similarly reduced PDK2 binding to E2.E1. Adenosine Diphosphate 8-11 pyruvate dehydrogenase kinase 2 Homo sapiens 38-42 10601323-2 1999 The activity of the K(ATP) channel, composed of SUR1 and Kir6.2 subunits, is regulated by intracellular ATP and ADP, but the molecular mechanism is not clear. Adenosine Diphosphate 112-115 ATP binding cassette subfamily C member 8 Homo sapiens 48-52 10613907-4 1999 Both point mutations that impair ANT-1 in its known activity to transport ADP and ATP as well as the NH(2)-terminal half of the protein could still induce apoptosis. Adenosine Diphosphate 74-77 Ant1p Saccharomyces cerevisiae S288C 33-38 10512721-7 1999 When GroES was present, ATP as well as ADP and AMP-PNP were effective in reducing the affinity between GroEL and the refolding intermediate of alpha-lactalbumin. Adenosine Diphosphate 39-42 heat shock protein family E (Hsp10) member 1 Homo sapiens 5-10 12747802-7 2003 Nucleotides inhibited the binding of Bz-[alpha-(32)P]ATP to VCP with the following efficiency: BzATP>ATP>ADP>>adenosine 5"-[beta,gamma-imido]triphosphate>or=adenosine 5"-[beta,gamma-methylene]triphosphate, whereas AMP, GTP and CTP were ineffective. Adenosine Diphosphate 111-114 valosin containing protein Homo sapiens 60-63 10506165-4 1999 ADP-induced platelet aggregation requires concomitant signaling from two P2 receptor subtypes, P2Y1 and P2T(AC), coupled to G(q) and G(i), respectively. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 104-111 12913786-2 2003 When platelets become activated by various soluble agonists or by adhesion to subendothelium under high shear, they release adenosine-5"-diphosphate that acts in a positive feedback mechanism on two different G-protein coupled receptors (P2Y(12), P2Y(1)) on platelets. Adenosine Diphosphate 124-148 purinergic receptor P2Y12 Homo sapiens 238-245 10518533-4 1999 Nucleotides (GTP > GDP > ATP > GMP = ADP, in order of decreasing efficiency) interfered with the formation of the PLCdelta1:TG complex. Adenosine Diphosphate 46-49 phospholipase C delta 1 Homo sapiens 123-132 10512757-0 1999 Formation of PI 3-kinase products in platelets by thrombin, but not collagen, is dependent on synergistic autocrine stimulation, particularly through secreted ADP. Adenosine Diphosphate 159-162 peptidase inhibitor 3 Homo sapiens 13-17 12913786-3 2003 This released adenosine-5"-diphosphate, acting through P2Y(12), is critical for sustained aggregation and stabilization of thrombi. Adenosine Diphosphate 14-38 purinergic receptor P2Y12 Homo sapiens 55-62 12913786-5 2003 Recent studies using either inhibitors of key components of signaling pathways or genetically engineered mice have contributed to our understanding of the signaling mechanisms in platelets mediated by adenosine-5"-diphosphate through the P2Y(12) receptor. Adenosine Diphosphate 201-225 purinergic receptor P2Y12 Homo sapiens 238-245 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 122-143 calcium and integrin binding 1 Homo sapiens 14-17 10493815-2 1999 Since this suggests that the induction of metastable complexes, which form in ATP but dissociate in ADP, may be a general property of DnaJ homologues, in the present study we investigated in more detail the ability of DnaJ homologues to induce polymerization of Hsc70. Adenosine Diphosphate 100-103 DnaJ heat shock protein family (Hsp40) member C14 Homo sapiens 134-138 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 145-148 calcium and integrin binding 1 Homo sapiens 14-17 10464326-5 1999 Characterization of the nature of the adduct suggests that it is between ArsA and ADP, instead of ATP, indicating that the adduct formation reflects hydrolysis of ATP. Adenosine Diphosphate 82-85 arylsulfatase A Homo sapiens 73-77 12714504-8 2003 These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading. Adenosine Diphosphate 136-139 calcium and integrin binding 1 Homo sapiens 41-44 10464326-9 1999 It is also proposed that ArsA goes through an ATP-bound and an ADP-bound conformation, and the linker region, where ADP binds under both unisite and multisite catalytic conditions, may play an important role in the energy transduction process. Adenosine Diphosphate 63-66 arylsulfatase A Homo sapiens 25-29 10464326-9 1999 It is also proposed that ArsA goes through an ATP-bound and an ADP-bound conformation, and the linker region, where ADP binds under both unisite and multisite catalytic conditions, may play an important role in the energy transduction process. Adenosine Diphosphate 116-119 arylsulfatase A Homo sapiens 25-29 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 64-67 male germ cell-associated kinase Mus musculus 10-16 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 69-72 male germ cell-associated kinase Mus musculus 10-16 12740376-1 2003 The ADP/ATP carrier (AAC) that facilitates the translocation of ATP made in mitochondria is inserted at the inner mitochondrial membrane by the TIM10-TIM22 protein import system. Adenosine Diphosphate 4-7 translocation channel protein TIM22 Saccharomyces cerevisiae S288C 150-155 12639955-4 2003 In the same temperature range, the ADP/ATP exchange factor GrpE undergoes an extensive, fully reversible thermal transition (Grimshaw, J. P. A., Jelesarov, I., Schonfeld, H. J., and Christen, P. (2001) J. Biol. Adenosine Diphosphate 35-38 GrpE like 1, mitochondrial Homo sapiens 59-63 10446209-5 1999 Agonist (ADP, thrombin, or U46619)-stimulated but not resting platelets adhered to both Cyr61 and Fisp12/mCTGF, and this process was completely inhibited by prostaglandin I(2), which prevents platelet activation. Adenosine Diphosphate 9-12 cellular communication network factor 2 Mus musculus 98-104 10446209-5 1999 Agonist (ADP, thrombin, or U46619)-stimulated but not resting platelets adhered to both Cyr61 and Fisp12/mCTGF, and this process was completely inhibited by prostaglandin I(2), which prevents platelet activation. Adenosine Diphosphate 9-12 cellular communication network factor 2 Mus musculus 105-110 10430961-9 1999 These findings suggest that in plants containing both isoforms, Rubisco activase regulates the activity of Rubisco in response to light-induced changes in both the ADP/ATP ratio and the redox potential via thioredoxin-f. Adenosine Diphosphate 164-167 thioredoxin H-type 1 Arabidopsis thaliana 206-217 10447592-1 1999 The KlAAC gene, encoding the ADP/ATP carrier in Kluveromyces lactis, has previously been cloned by complementation of the op1(aac2) mutation of Saccharomyces cerevisiae. Adenosine Diphosphate 29-32 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 126-130 12639955-9 2003 With disulfide-stabilized GrpE, the rate of ADP/ATP exchange and conversion of DnaK from its ADP-liganded high affinity R state to the ATP-liganded low affinity T state continuously increased with increasing temperature. Adenosine Diphosphate 44-47 GrpE like 1, mitochondrial Homo sapiens 26-30 10447592-8 1999 The Klaac mutation was fully complemented not only by AAC2, the major gene for the ADP/ATP carrier in S. cerevisiae, but also by AAC1, a gene which is poorly expressed in S. cerevisiae. Adenosine Diphosphate 83-86 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 54-58 12639955-9 2003 With disulfide-stabilized GrpE, the rate of ADP/ATP exchange and conversion of DnaK from its ADP-liganded high affinity R state to the ATP-liganded low affinity T state continuously increased with increasing temperature. Adenosine Diphosphate 93-96 GrpE like 1, mitochondrial Homo sapiens 26-30 14610915-1 2003 With the cloning of the P2Y12 receptor, the molecular basis for ADP-induced platelet aggregation is seemingly complete. Adenosine Diphosphate 64-67 purinergic receptor P2Y12 Homo sapiens 24-29 10388765-1 1999 When smooth muscle myosin subfragment 1 (S1) is bound to actin filaments in vitro, the light chain domain tilts upon release of MgADP, producing a approximately 3.5-nm axial motion of the head-rod junction (Whittaker et al., 1995. Adenosine Diphosphate 128-133 myosin, heavy chain 15 Gallus gallus 19-25 12850840-0 2003 Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Adenosine Diphosphate 43-46 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 80-88 10354494-7 1999 The ADP/O ratios coupled to NADH oxidation were lowered from 2.4 to 1.8 by NDI1-transfection while the ADP/O ratios coupled to succinate oxidation (1.6) were not changed. Adenosine Diphosphate 4-7 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 75-79 10222010-4 1999 Photometric assay using pyruvate kinase and lactate dehydrogenase as auxiliary enzymes is not feasible in crude extracts because of endogenous ATPase activities, which regenerate ADP from the ATP released by pyruvate kinase. Adenosine Diphosphate 179-182 dynein axonemal heavy chain 8 Homo sapiens 143-149 12628919-9 2003 Dwell time analysis of beads carrying single myosin XI molecules fitted the ATPase kinetics, with ADP release being rate limiting. Adenosine Diphosphate 98-101 myosin-6-like Nicotiana tabacum 45-54 10090754-2 1999 Fhit catalyzes the hydrolysis of diadenosine triphosphate (Ap3A) to AMP and ADP. Adenosine Diphosphate 76-79 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 10090754-3 1999 Fhit is here shown to catalyze the hydrolysis in H218O with production of adenosine 5"-[18O]phosphate and ADP, proving that the substitution of water is at Palpha and not at Pbeta. Adenosine Diphosphate 106-109 fragile histidine triad diadenosine triphosphatase Homo sapiens 0-4 12615691-2 2003 One of the receptors involved in ADP-induced platelet activation is the P2Y12 receptor, which is a target for antithrombotic drugs. Adenosine Diphosphate 33-36 purinergic receptor P2Y12 Homo sapiens 72-77 9990013-4 1999 Here, we report that MgATP and MgADP, but not the Mg salt of gamma-thio-ATP, stabilize the binding of prebound 8-azido-[alpha-32P]ATP to SUR1. Adenosine Diphosphate 31-36 ATP binding cassette subfamily C member 8 Homo sapiens 137-141 12615691-9 2003 CONCLUSIONS: These findings demonstrate that ADP and its P2Y12 receptor are involved in thrombus growth and especially in the formation of emboli on the downstream side of the initial thrombus. Adenosine Diphosphate 45-48 purinergic receptor P2Y12 Homo sapiens 57-62 9990013-5 1999 Mutation in the Walker A and B motifs of NBF2 of SUR1 abolished this stabilizing effect of MgADP. Adenosine Diphosphate 91-96 ATP binding cassette subfamily C member 8 Homo sapiens 49-53 12604678-7 2003 MgADP or MgUDP (100 microM) augmented the inhibitory effect of nateglinide on SUR1/Kir6.2 but not SUR1(S1237Y)/Kir6.2 or SUR2A/Kir6.2 channels. Adenosine Diphosphate 0-5 ATP binding cassette subfamily C member 8 Homo sapiens 78-82 9990013-6 1999 These results suggest that SUR1 binds 8-azido-ATP strongly at NBF1 and that MgADP, either by direct binding to NBF2 or by hydrolysis of bound MgATP at NBF2, stabilizes prebound 8-azido-ATP binding at NBF1. Adenosine Diphosphate 76-81 ATP binding cassette subfamily C member 8 Homo sapiens 27-31 9990013-7 1999 The sulfonylurea glibenclamide caused release of prebound 8-azido-[alpha-32P]ATP from SUR1 in the presence of MgADP or MgATP in a concentration-dependent manner. Adenosine Diphosphate 110-115 ATP binding cassette subfamily C member 8 Homo sapiens 86-90 9990013-8 1999 This direct biochemical evidence of cooperative interaction in nucleotide binding of the two NBFs of SUR1 suggests that glibenclamide both blocks this cooperative binding of ATP and MgADP and, in cooperation with the MgADP bound at NBF2, causes ATP to be released from NBF1. Adenosine Diphosphate 182-187 ATP binding cassette subfamily C member 8 Homo sapiens 101-105 9990013-8 1999 This direct biochemical evidence of cooperative interaction in nucleotide binding of the two NBFs of SUR1 suggests that glibenclamide both blocks this cooperative binding of ATP and MgADP and, in cooperation with the MgADP bound at NBF2, causes ATP to be released from NBF1. Adenosine Diphosphate 217-222 ATP binding cassette subfamily C member 8 Homo sapiens 101-105 12604678-8 2003 This augmenting effect of MgADP was also observed with the SUR1/Kir6.2(K185Q) channel, which was not inhibited by MgADP, but not with the SUR1(K1384A)/Kir6.2 channel, which was not activated by MgADP. Adenosine Diphosphate 26-31 ATP binding cassette subfamily C member 8 Homo sapiens 59-63 12648570-5 2003 A single-ring GroEL/GroES variant complexed with one dPJ9 molecule was used to study the structural changes of dPJ9 in GroEL/GroES/dPJ9 complexes formed with ADP and with ATP. Adenosine Diphosphate 158-161 heat shock protein family E (Hsp10) member 1 Homo sapiens 20-25 10068199-6 1999 The development of ADP was selectively blocked in DDC-fed TGF-beta1 transgenic mice producing active TGF-beta1 in the liver and no accumulation of new hepatocytes expressing the A6 antigen was observed. Adenosine Diphosphate 19-22 transforming growth factor, beta 1 Mus musculus 58-67 10068199-6 1999 The development of ADP was selectively blocked in DDC-fed TGF-beta1 transgenic mice producing active TGF-beta1 in the liver and no accumulation of new hepatocytes expressing the A6 antigen was observed. Adenosine Diphosphate 19-22 transforming growth factor, beta 1 Mus musculus 101-110 10078208-3 1999 We demonstrate that mismmatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts hMSH2-hMSH6 into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. Adenosine Diphosphate 45-48 mutS homolog 2 Homo sapiens 135-140 12648570-5 2003 A single-ring GroEL/GroES variant complexed with one dPJ9 molecule was used to study the structural changes of dPJ9 in GroEL/GroES/dPJ9 complexes formed with ADP and with ATP. Adenosine Diphosphate 158-161 heat shock protein family E (Hsp10) member 1 Homo sapiens 125-130 9843180-1 1998 We have previously shown that human platelets express matrix metalloproteinase-2 (MMP-2) and that the release of this enzyme during platelet activation mediates the ADP- and thromboxane-independent part of aggregation. Adenosine Diphosphate 165-168 matrix metallopeptidase 2 Homo sapiens 54-80 9843180-1 1998 We have previously shown that human platelets express matrix metalloproteinase-2 (MMP-2) and that the release of this enzyme during platelet activation mediates the ADP- and thromboxane-independent part of aggregation. Adenosine Diphosphate 165-168 matrix metallopeptidase 2 Homo sapiens 82-87 12648570-6 2003 It was found that both the shape and the position of the bound dPJ9 in the GroEL/GroES/dPJ9 complex with ADP were the same as those in the GroEL/dPJ9 complex. Adenosine Diphosphate 105-108 heat shock protein family E (Hsp10) member 1 Homo sapiens 81-86 24616605-8 2003 After ADP-stimulation an increase from 4.18+-1.02 to 5.69+-1.40 %PC in CD62P (p<0.01) and from 45.7+-3.4 to 57.9+-6.6 %PC in PAC1 (p<0.05) after TR were detected. Adenosine Diphosphate 6-9 dual specificity phosphatase 2 Homo sapiens 128-132 9726996-9 1998 ADP or GDP at higher concentrations was inhibitory, reflecting NDP binding to the substrate site. Adenosine Diphosphate 0-3 norrin cystine knot growth factor NDP Homo sapiens 63-66 9639574-6 1998 The assembly of mammalian OGC and fungal ADP/ATP carrier occurs with high efficiency in both mammalian and yeast mitochondria. Adenosine Diphosphate 41-44 solute carrier family 25 member 11 Homo sapiens 26-29 12496311-7 2003 The F1388L-SUR1 channel has increased sensitivity to MgADP and metabolic inhibition, decreased sensitivity to glibenclamide, and responds to both diazoxide and pinacidil. Adenosine Diphosphate 53-58 ATP binding cassette subfamily C member 8 Homo sapiens 11-15 9618560-4 1998 The beta cell KATP channel is a complex of four Kir6.2 pore-forming subunits and four SUR1 regulatory subunits: Kir6.2 mediates channel inhibition by ATP, whereas the potentiatory action of MgADP involves the nucleotide-binding domains (NBDs) of SUR1. Adenosine Diphosphate 190-195 ATP binding cassette subfamily C member 8 Homo sapiens 86-90 9618560-4 1998 The beta cell KATP channel is a complex of four Kir6.2 pore-forming subunits and four SUR1 regulatory subunits: Kir6.2 mediates channel inhibition by ATP, whereas the potentiatory action of MgADP involves the nucleotide-binding domains (NBDs) of SUR1. Adenosine Diphosphate 190-195 ATP binding cassette subfamily C member 8 Homo sapiens 246-250 12578987-6 2003 Neither mutation interfered with receptor surface expression but both altered function, since ADP inhibited the forskolin-induced increase of cAMP markedly less in cells transfected with either mutant P2Y(12) as compared with wild-type receptor. Adenosine Diphosphate 94-97 purinergic receptor P2Y12 Homo sapiens 201-208 9618560-8 1998 These results suggest that, like MgADP, MgATP stimulates KATP channel activity by interaction with the NBDs of SUR1. Adenosine Diphosphate 33-38 ATP binding cassette subfamily C member 8 Homo sapiens 111-115 12578987-7 2003 These studies delineate a region of P2Y(12) required for normal function after ADP binding. Adenosine Diphosphate 79-82 purinergic receptor P2Y12 Homo sapiens 36-43 9593663-6 1998 Like other synapsins, synapsin IIIa binds ATP with high affinity and ADP with a lower affinity, consistent with a cycle of ATP binding and hydrolysis. Adenosine Diphosphate 69-72 synapsin III Homo sapiens 22-35 12574814-6 2003 In contrast, platelet activation with TRAP, epinephrine, or ADP produced markedly increased gC1qR expression as reflected by 74.5.2 binding but not 60.11 binding. Adenosine Diphosphate 60-63 complement C1q binding protein Homo sapiens 92-97 9576109-5 1998 Despite a similar contractile response, M/MtCK-/- hearts increased [ADP] by 95%, whereas wild-type and MCK-/- hearts maintained [ADP] at baseline levels. Adenosine Diphosphate 68-71 creatine kinase, mitochondrial 1, ubiquitous Mus musculus 42-46 12407113-4 2003 Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine. Adenosine Diphosphate 226-229 RAP1B, member of RAS oncogene family Homo sapiens 109-114 12407113-4 2003 Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine. Adenosine Diphosphate 226-229 Fc gamma receptor IIa Homo sapiens 170-181 12407113-5 2003 However, in platelets from PI3Kgamma-deficient mice, both ADP and epinephrine were still able to normally stimulate Rap1B activation through a PI3K-dependent mechanism, suggesting the involvement of a different isoform of the enzyme. Adenosine Diphosphate 58-61 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 27-36 9556620-4 1998 Approximately 30% of the total amount of PCI in platelets was released after stimulation with ADP, collagen, adrenalin, thrombin, or thrombin receptor-activating peptide. Adenosine Diphosphate 94-97 serpin family A member 5 Homo sapiens 41-44 12434150-3 2002 Three-dimensional maps show that the two AAA domains, D1 and D2, as well as the N-domains, experience conformational changes during ATP binding, ATP hydrolysis, P(i) release and ADP release. Adenosine Diphosphate 178-181 leiomodin 1 Homo sapiens 54-63 9553768-1 1998 Ecto-ATPase, a transmembrane enzyme that catalyzes the hydrolysis of extracellular ATP (ATPe) to ADP and inorganic phosphate, is expressed upon cell activation. Adenosine Diphosphate 97-100 ATP synthase F1 subunit epsilon Homo sapiens 88-92 12138099-3 2002 The PK-treated ATPase was unable to transport Ca(2+) and to catalyze ATP hydrolysis, but it could bind two calcium ions with high affinity and react with ATP to form a classical ADP-sensitive phosphoenzyme, Ca(2)E1P, with occluded Ca(2+). Adenosine Diphosphate 178-181 dynein axonemal heavy chain 8 Homo sapiens 15-21 9889819-3 1998 (Biochemistry 34, 8960-8972, 1995) have proposed that in an important transition of myosin heads (M), M.ATP-->M.ADP.Pi, an interdomain rotation occurs in Gly468 (of chicken smooth muscle myosin) and that the rotated state is stabilized by newly-formed interdomain contacts including the salt link between Glu470 and Arg247 (of chicken smooth muscle myosin). Adenosine Diphosphate 115-118 myosin, heavy chain 15 Gallus gallus 84-90 9889819-3 1998 (Biochemistry 34, 8960-8972, 1995) have proposed that in an important transition of myosin heads (M), M.ATP-->M.ADP.Pi, an interdomain rotation occurs in Gly468 (of chicken smooth muscle myosin) and that the rotated state is stabilized by newly-formed interdomain contacts including the salt link between Glu470 and Arg247 (of chicken smooth muscle myosin). Adenosine Diphosphate 115-118 myosin, heavy chain 15 Gallus gallus 190-196 9889819-3 1998 (Biochemistry 34, 8960-8972, 1995) have proposed that in an important transition of myosin heads (M), M.ATP-->M.ADP.Pi, an interdomain rotation occurs in Gly468 (of chicken smooth muscle myosin) and that the rotated state is stabilized by newly-formed interdomain contacts including the salt link between Glu470 and Arg247 (of chicken smooth muscle myosin). Adenosine Diphosphate 115-118 myosin, heavy chain 15 Gallus gallus 190-196 12138099-4 2002 The ability of Ca(2)E1P to become converted to the Ca(2+)-free ADP-insensitive form, E2P, was strongly reduced, as was the ability of PK-treated ATPase to react with orthovanadate or to form an E2P intermediate from inorganic phosphate in the absence of Ca(2+). Adenosine Diphosphate 63-66 dynein axonemal heavy chain 8 Homo sapiens 145-151 16793682-1 1998 Agonist (collagen- or ADP-)-stimulated platelet aggregation and thromboxane B(2) (T X B(2) ) production was reduced in human whole blood (WB) and washed platelets (WP) that were co-incubated with lipoprotein (a)[Lp(a)] at levels of 25, 50 and 100 mg % but not at 5 mg % relative to a baseline concentration of 1 mg %. Adenosine Diphosphate 22-25 lipoprotein(a) Homo sapiens 212-217 16793682-6 1998 These results strongly suggest that Lp(a)-induced decreases in collagen or ADP stimulated platelet aggregation and T X B(2) production are mediated by apo(a). Adenosine Diphosphate 75-78 lipoprotein(a) Homo sapiens 36-41 16793695-3 1998 The abnormality is likely due to a severe defect of the platelet ADP receptor that is coupled to adenylate cyclase, as suggested by the following findings: 1) ADP does not normally lower cAMP levels of PGE1-treated platelets; 2) platelet shape change induced by ADP is normal; 3) the binding of [radiolabelled]ADP to formalin-fixed platelets or of the ADP analogue [radiolabelled]2-MeS-ADP to fresh platelets is severely defective. Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 56-77 16793695-3 1998 The abnormality is likely due to a severe defect of the platelet ADP receptor that is coupled to adenylate cyclase, as suggested by the following findings: 1) ADP does not normally lower cAMP levels of PGE1-treated platelets; 2) platelet shape change induced by ADP is normal; 3) the binding of [radiolabelled]ADP to formalin-fixed platelets or of the ADP analogue [radiolabelled]2-MeS-ADP to fresh platelets is severely defective. Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 56-77 16793695-3 1998 The abnormality is likely due to a severe defect of the platelet ADP receptor that is coupled to adenylate cyclase, as suggested by the following findings: 1) ADP does not normally lower cAMP levels of PGE1-treated platelets; 2) platelet shape change induced by ADP is normal; 3) the binding of [radiolabelled]ADP to formalin-fixed platelets or of the ADP analogue [radiolabelled]2-MeS-ADP to fresh platelets is severely defective. Adenosine Diphosphate 159-162 purinergic receptor P2Y12 Homo sapiens 56-77 12187107-1 2002 It has been demonstrated in anti-Thy1 glomerulonephritis that extracellular adenine nucleotides have a significant pro-inflammatory activity, however, glomerular ATP/ADPase, which in concert with 5"-nucleotidase converts ATP/ADP, and AMP to anti-inflammatory adenosine had an anti-inflammatory role. Adenosine Diphosphate 166-169 5'-nucleotidase ecto Homo sapiens 196-211 9395399-3 1997 A protein disulfide isomerase that is localized to the chloroplast and copurifies with cPABP was shown to modulate the binding of cPABP to the 5"-UTR of the psbA mRNA by reversibly changing the redox status of cPABP through redox potential or adenosine 5"-diphosphate-dependent phosphorylation. Adenosine Diphosphate 243-267 prolyl 4-hydroxylase subunit beta Homo sapiens 2-29 9354620-10 1997 In contrast to the RecA filament, the structure of XRad51.1 filament with ADP is not significantly different from that with ATP. Adenosine Diphosphate 74-77 RAD51 recombinase S homeolog Xenopus laevis 51-59 11978175-5 2002 90 degrees C. Biochemical characterization of these enzymes confirmed that the ADP-GLK is unable to use ATP as the phosphoryl group donor, but revealed that GALK is ATP-dependent and has an extremely high affinity for ATP. Adenosine Diphosphate 79-82 galactokinase 1 Homo sapiens 157-161 9321400-5 1997 Similar to the action of the GrpE protein on bacterial Hsp70, BAG-1 accelerates the release of ADP from Hsc70. Adenosine Diphosphate 95-98 GrpE like 1, mitochondrial Homo sapiens 29-33 12036965-1 2002 Guanylate kinase (GMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryl transfer from ATP to GMP to yield ADP and GDP. Adenosine Diphosphate 136-139 5'-nucleotidase, cytosolic II Mus musculus 18-21 9287292-0 1997 MgADP antagonism to Mg2+-independent ATP binding of the sulfonylurea receptor SUR1. Adenosine Diphosphate 0-5 ATP binding cassette subfamily C member 8 Homo sapiens 78-82 9287292-8 1997 These results show that SUR1, unlike other ABC proteins, strongly binds ATP at NBF1 even in the absence of Mg2+ and that MgADP, through binding at NBF2, antagonizes the Mg2+-independent high affinity ATP binding at NBF1. Adenosine Diphosphate 121-126 ATP binding cassette subfamily C member 8 Homo sapiens 24-28 9287137-3 1997 RP specifically inactivates PPDK in the dark by an ADP-dependent phosphorylation of an active-site Thr residue (Thr-456 in maize). Adenosine Diphosphate 51-54 pyruvate, phosphate dikinase 1, chloroplastic Zea mays 28-32 12145099-2 2002 Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SUR1 and to SUR2 mutants with high glibenclamide affinity, SUR2A(Y1206S) and SUR2B(Y1206S). Adenosine Diphosphate 67-72 ATP binding cassette subfamily C member 8 Homo sapiens 101-105 9238070-5 1997 The site at which ATP mediates channel inhibition lies on Kir6.2, while the potentiatory action of MgADP involves the nucleotide-binding domains of SUR1. Adenosine Diphosphate 99-104 ATP binding cassette subfamily C member 8 Homo sapiens 148-152 9387093-2 1997 Drawing on the hexokinase-mitochondrial acceptor theory of insulin action, this article presents evidence suggesting that the increased binding of hexokinase to porin on mitochondria of cancer cells not only accelerates glycolysis by providing hexokinase with better access to ATP, but also stimulates the TCA cycle by providing the mitochondrion with ADP that acts as an acceptor for phosphoryl groups. Adenosine Diphosphate 352-355 voltage dependent anion channel 1 Homo sapiens 161-166 12145099-2 2002 Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SUR1 and to SUR2 mutants with high glibenclamide affinity, SUR2A(Y1206S) and SUR2B(Y1206S). Adenosine Diphosphate 67-72 ATP binding cassette subfamily C member 9 Homo sapiens 113-117 9237625-4 1997 In the presence of AMP the ATPase reaction was superseded by the formation of two ADP from ATP and AMP. Adenosine Diphosphate 82-85 dynein axonemal heavy chain 8 Homo sapiens 27-33 12145099-5 2002 3: Glibenclamide inhibition curves for ADP, performed in the presence of an ATP-consuming system to oppose ATP formation from ADP, were generally shifted rightwards and showed positive cooperativity, in particular with the SUR2(Y1206S) isoforms. Adenosine Diphosphate 39-42 ATP binding cassette subfamily C member 9 Homo sapiens 223-227 12145099-9 2002 6: The data show (a) that the inhibitory effects of ATP and ADP on glibenclamide binding differ from one another, (b) that they depend on the SUR subtype, and (c) that they are weakened by coexpression with Kir6.2. Adenosine Diphosphate 60-63 ATP binding cassette subfamily C member 8 Homo sapiens 142-145 12230889-3 2002 This is demonstrated by the example of ATP hydrolysis by Ca(2+)-ATPase: The substrate concentration can be followed using the infrared absorption of the alpha- and beta-PO(2)(-) phosphate groups of ATP, and the product concentration can be followed using the PO(3)(2-) absorption of P(i) and of the beta-phosphate of ADP. Adenosine Diphosphate 317-320 dynein axonemal heavy chain 8 Homo sapiens 64-70 9144288-6 1997 We show here that the primary site at which ATP acts to mediate K-ATP channel inhibition is located on Kir6.2, and that SUR1 is required for sensitivity to sulphonylureas and diazoxide and for activation by Mg-ADP. Adenosine Diphosphate 207-213 ATP binding cassette subfamily C member 8 Homo sapiens 120-124 12413588-7 2002 Platelets from aspirin-resistant patients bound PAC-1 significantly more (p=0.03) than the aspirin-sensitive patients and controls when activated with 10 micro M ADP. Adenosine Diphosphate 162-165 dual specificity phosphatase 2 Homo sapiens 48-53 9184383-13 1997 The monoclonal antibody anti-Fc gamma RIIa1, I-3 (2 micrograms/ml), abolished SK-induced platelet aggregation and SK-enhanced ADP-induced platelet aggregation. Adenosine Diphosphate 126-129 brain protein I3 Homo sapiens 29-48 11940582-7 2002 Actin activation of the ATPase activity and the low K(ATPase) are the result of actin activation of ADP release. Adenosine Diphosphate 100-103 dynein axonemal heavy chain 8 Homo sapiens 24-30 9134653-5 1997 In contrast, with plasmin-pretreated platelets, aggregation and release of 14C-serotonin were strongly potentiated in response to low concentrations of the thrombin receptor-activating peptide SFLLRN, ADP, platelet-activating factor, collagen, arachidonic acid, the thromboxane mimetic U46619, and the calcium ionophores A23187 and ionomycin. Adenosine Diphosphate 201-204 plasminogen Homo sapiens 18-25 9135131-0 1997 The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. Adenosine Diphosphate 81-87 ATP binding cassette subfamily C member 8 Homo sapiens 45-49 9029013-9 1997 Moreover, the signals generated by CD9 and PTA1 antigens differed significantly in their sensitivity to PKC inhibition or ADP-ribosylation of the small GTP-binding protein rhoA. Adenosine Diphosphate 122-125 CD226 molecule Homo sapiens 43-47 11940582-7 2002 Actin activation of the ATPase activity and the low K(ATPase) are the result of actin activation of ADP release. Adenosine Diphosphate 100-103 dynein axonemal heavy chain 8 Homo sapiens 52-61 11950878-6 2002 Moreover, CAP1 and its C-terminal domain were observed to facilitate filament elongation at the barbed end and to stimulate ADP-ATP exchange on G-actin, a process that regenerates easily polymerizable G-actin. Adenosine Diphosphate 124-127 cyclase associated actin cytoskeleton regulatory protein 1 Homo sapiens 10-14 9025303-0 1997 Characterization of a novel eukaryotic ATP/ADP translocator located in the plastid envelope of Arabidopsis thaliana L. Recently, we have sequenced a cDNA clone from Arabidopsis thaliana L. encoding a novel putative ATP/ADP translocator (AATP1). Adenosine Diphosphate 43-46 AAA-ATPase 1 Arabidopsis thaliana 237-242 9025303-0 1997 Characterization of a novel eukaryotic ATP/ADP translocator located in the plastid envelope of Arabidopsis thaliana L. Recently, we have sequenced a cDNA clone from Arabidopsis thaliana L. encoding a novel putative ATP/ADP translocator (AATP1). Adenosine Diphosphate 219-222 AAA-ATPase 1 Arabidopsis thaliana 237-242 9025303-9 1997 The data presented here strongly support the conclusion that AATP1 represents a novel eukaryotic adenylate carrier and that it is identical with the so far unknown plastidic ATP/ADP translocator. Adenosine Diphosphate 178-181 AAA-ATPase 1 Arabidopsis thaliana 61-66 11959146-3 2002 DNA binding activity of CLK-1 is inhibited by ADP, and is altered by mutations that extend nematode life span. Adenosine Diphosphate 46-49 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 24-29 8973184-5 1996 Conformational changes of the isolated wild-type and Trp-substituted Anc2p variants, induced upon binding of specific substrates [adenosine triphosphate (ATP) or diphosphate (ADP)] or inhibitors [carboxyatractyloside (CATR) or bongkrekic acid (BA)], were studied by measurement of intrinsic fluorescence. Adenosine Diphosphate 175-178 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 69-74 8943246-4 1996 Intrinsic fluorescence studies of the two mutants reveal that nucleotide binding (ADP or AMP-PNP (adenosine 5"-(beta,gamma-imino)triphosphate)) induces conformational changes in the tetradecamer that are independent of the presence of the co-chaperonin, GroES. Adenosine Diphosphate 82-85 heat shock protein family E (Hsp10) member 1 Homo sapiens 254-259 11815620-5 2002 Similarly, direct stimulation of platelets with ADP induced the rapid activation of Rap1B. Adenosine Diphosphate 48-51 RAP1B, member of RAS oncogene family Homo sapiens 84-89 8943290-1 1996 5-Oxoprolinase (EC 3.5.2) catalyzes a reaction in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergonic hydrolysis of ATP to ADP and inorganic phosphate. Adenosine Diphosphate 168-171 5-oxoprolinase (ATP-hydrolysing) Rattus norvegicus 0-14 8972712-9 1996 Thus, released endogenous ADP selectively prevents PGE1-mediated tyrosine dephosphorylation of platelet FAK most likely by stabilizing fibrinogen binding to platelets. Adenosine Diphosphate 26-29 protein tyrosine kinase 2 Homo sapiens 104-107 11815620-7 2002 By contrast, prevention of ADP binding to the P2Y12 receptor totally suppressed activation of Rap1B without affecting Ca(2+) signaling. Adenosine Diphosphate 27-30 purinergic receptor P2Y12 Homo sapiens 46-51 8699126-3 1996 When anti-CD11a or anti-CD11b was added to neutrophils with PRPr, ATP, or ADP, the adhesion-increasing action was cancelled or considerably repressed. Adenosine Diphosphate 74-77 integrin subunit alpha L Homo sapiens 10-15 11815620-7 2002 By contrast, prevention of ADP binding to the P2Y12 receptor totally suppressed activation of Rap1B without affecting Ca(2+) signaling. Adenosine Diphosphate 27-30 RAP1B, member of RAS oncogene family Homo sapiens 94-99 11815620-8 2002 In platelets stimulated by cross-linking of FcgammaRIIA, inhibition of Rap1B activation by ADP scavengers could be overcome by the simultaneous recruitment of the G(i)-coupled alpha(2A)-adrenergic receptor by epinephrine. Adenosine Diphosphate 91-94 RAP1B, member of RAS oncogene family Homo sapiens 71-76 11815620-11 2002 Finally, activation of Rap1B induced by stimulation of the G(q)-coupled thromboxane A(2) receptor by was completely inhibited by ADP scavengers under conditions in which intracellular Ca(2+) mobilization was unaffected. Adenosine Diphosphate 129-132 RAP1B, member of RAS oncogene family Homo sapiens 23-28 11815620-13 2002 These results demonstrate that stimulation of a G(i)-dependent signaling pathway by either ADP of epinephrine is necessary and sufficient to activate the small GTPase Rap1B. Adenosine Diphosphate 91-94 RAP1B, member of RAS oncogene family Homo sapiens 167-172 8662655-4 1996 Their interactions with phosducin were determined in a variety of assays for beta gamma function: support of ADP-ribosylation of alpha 0 by pertussis toxin, enhancement of the GTPase activity of alpha 0, and enhancement of rhodopsin phosphorylation by the beta-adrenergic receptor kinase 1 (betaARK1). Adenosine Diphosphate 109-112 phosducin Bos taurus 24-33 11950711-11 2002 This suggested that P2Y(12) and P2Y(1) were both involved in platelet adhesion on immobilized fibrinogen, thereby revealing it as ADP dependent. Adenosine Diphosphate 130-133 purinergic receptor P2Y12 Homo sapiens 20-27 11904526-3 2002 Adenosine diphosphate (ADP)-induced expression of P-selectin and of PAC-1 was significantly reduced after 2 wk of clopidogrel but not of ASA treatment. Adenosine Diphosphate 0-21 dual specificity phosphatase 2 Homo sapiens 68-73 8601584-5 1996 These rate constants define an ATPase mechanism in which (a) ATP rapidly dissociates actomyosin-I, (b) the predominant steady-state intermediates are in a rapid equilibrium between actin-bound and free states, (c) phosphate release is rate limiting and regulated by heavy-chain phosphorylation, and (d) ADP release is fast. Adenosine Diphosphate 303-306 dynein axonemal heavy chain 8 Homo sapiens 31-37 11904526-3 2002 Adenosine diphosphate (ADP)-induced expression of P-selectin and of PAC-1 was significantly reduced after 2 wk of clopidogrel but not of ASA treatment. Adenosine Diphosphate 23-26 dual specificity phosphatase 2 Homo sapiens 68-73 11812157-6 2002 Complexes between actin.ADP and ADF or cofilin associate with both barbed and pointed ends of filaments at similar rates (close to those of actin.ATP and much higher than those of actin.ADP). Adenosine Diphosphate 186-189 destrin, actin depolymerizing factor Homo sapiens 32-35 9001693-5 1996 On the contrary, after ADP stimulation the percentage of PAC-1-positive activated platelets was significantly reduced in neonates compared to adults (22 vs. 66%; p < 0.001) and even more after U 46619 (11 vs. 72%; p < 0.001). Adenosine Diphosphate 23-26 dual specificity phosphatase 2 Homo sapiens 57-62 9001693-7 1996 The reduced platelet activation after ADP and U 46619 persisted at day 4 both with PAC-1 and with anti-GMP-140. Adenosine Diphosphate 38-41 dual specificity phosphatase 2 Homo sapiens 83-88 11812157-6 2002 Complexes between actin.ADP and ADF or cofilin associate with both barbed and pointed ends of filaments at similar rates (close to those of actin.ATP and much higher than those of actin.ADP). Adenosine Diphosphate 186-189 cofilin 1 Homo sapiens 39-46 11812157-8 2002 The major difference between the two proteins is that the nucleating activity of cofilin-actin.ADP complexes is twice that of ADF-actin.ADP complexes and this, in turn, is twice that of actin.ATP alone. Adenosine Diphosphate 95-98 cofilin 1 Homo sapiens 81-88 8547637-2 1996 However, platelet spreading and tyrosine phosphorylation of three proteins, the focal adhesion kinase pp125FAK and proteins of 101 and 105 kD (pp101 and pp105), require a second adenosine diphosphate (ADP)-dependent costimulatory event. Adenosine Diphosphate 178-199 protein tyrosine kinase 2 Homo sapiens 102-110 8547637-2 1996 However, platelet spreading and tyrosine phosphorylation of three proteins, the focal adhesion kinase pp125FAK and proteins of 101 and 105 kD (pp101 and pp105), require a second adenosine diphosphate (ADP)-dependent costimulatory event. Adenosine Diphosphate 201-204 protein tyrosine kinase 2 Homo sapiens 102-110 8547637-6 1996 In addition, the inhibitory effects of apyrase, an ADP scavenger, on spreading and tyrosine phosphorylation of pp125FAK, pp101, and pp105, were not observed in the presence of phorbol 12-myristate 13-acetate (PMA). Adenosine Diphosphate 51-54 protein tyrosine kinase 2 Homo sapiens 111-119 11812157-8 2002 The major difference between the two proteins is that the nucleating activity of cofilin-actin.ADP complexes is twice that of ADF-actin.ADP complexes and this, in turn, is twice that of actin.ATP alone. Adenosine Diphosphate 95-98 destrin, actin depolymerizing factor Homo sapiens 126-129 11812157-8 2002 The major difference between the two proteins is that the nucleating activity of cofilin-actin.ADP complexes is twice that of ADF-actin.ADP complexes and this, in turn, is twice that of actin.ATP alone. Adenosine Diphosphate 136-139 cofilin 1 Homo sapiens 81-88 8719936-0 1995 An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats. Adenosine Diphosphate 84-87 aldo-keto reductase family 1 member B1 Rattus norvegicus 3-19 11812157-8 2002 The major difference between the two proteins is that the nucleating activity of cofilin-actin.ADP complexes is twice that of ADF-actin.ADP complexes and this, in turn, is twice that of actin.ATP alone. Adenosine Diphosphate 136-139 destrin, actin depolymerizing factor Homo sapiens 126-129 11841696-8 2002 Furthermore, flow cytometry demonstrated that the platelet fraction expressed P-selectin and an activation motif on GPIIb/IIIa recognized by monoclonal antibody PAC-1 upon stimulation with adenosine diphosphate (ADP). Adenosine Diphosphate 189-210 dual specificity phosphatase 2 Homo sapiens 161-166 7559652-5 1995 Elevated rhoB mRNA was accompanied by an increase in RhoB protein, as detected by C3-mediated [32P]ADP-ribosylation. Adenosine Diphosphate 99-102 ras homolog family member B Mus musculus 9-13 7559652-5 1995 Elevated rhoB mRNA was accompanied by an increase in RhoB protein, as detected by C3-mediated [32P]ADP-ribosylation. Adenosine Diphosphate 99-102 ras homolog family member B Mus musculus 53-57 11841696-8 2002 Furthermore, flow cytometry demonstrated that the platelet fraction expressed P-selectin and an activation motif on GPIIb/IIIa recognized by monoclonal antibody PAC-1 upon stimulation with adenosine diphosphate (ADP). Adenosine Diphosphate 212-215 dual specificity phosphatase 2 Homo sapiens 161-166 11673467-2 2001 Is a decreased sensitivity to inhibitory ATP required, or is the Mg-ADP/ATP-dependent stimulatory action of the ATPase, sulfonylurea receptor (SUR), on K(IR) sufficient to elicit a physiologically significant open channel probability? Adenosine Diphosphate 65-71 ATP binding cassette subfamily C member 8 Homo sapiens 120-141 8568673-7 1995 ADP stimulated BKCa channel activity in a Mg(2+)-dependent manner, an action also inhibited by the concomitant application of PKI or BDM. Adenosine Diphosphate 0-3 potassium calcium-activated channel subfamily M alpha 1 Rattus norvegicus 15-19 11673467-2 2001 Is a decreased sensitivity to inhibitory ATP required, or is the Mg-ADP/ATP-dependent stimulatory action of the ATPase, sulfonylurea receptor (SUR), on K(IR) sufficient to elicit a physiologically significant open channel probability? Adenosine Diphosphate 65-71 ATP binding cassette subfamily C member 8 Homo sapiens 143-146 11779463-3 2001 These observations, together with the effects of ATP binding to a GroEL-GroES-ADP complex, suggest structural models for the ATP-induced reduction in affinity for polypeptide and for cooperativity. Adenosine Diphosphate 78-81 heat shock protein family E (Hsp10) member 1 Homo sapiens 72-77 7635215-0 1995 ADP release is the rate-limiting step of the MT activated ATPase of non-claret disjunctional and kinesin. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 58-64 7789510-1 1995 The ADP(Mg2+)-deactivated oligomycin-sensitive F1-F0 ATPase of coupled submitochondrial particles treated with the substoichiometric amount of oligomycin was studied to test whether ATP synthesis and hydrolysis proceed in either direction through the same intermediates. Adenosine Diphosphate 4-7 dynein axonemal heavy chain 8 Homo sapiens 53-59 7663422-3 1995 The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 28-31 7663422-3 1995 The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 61-64 7663422-3 1995 The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 61-64 7663422-3 1995 The polyamines compete with Mg2+ for common binding sites on Mg2+ buffers such as ATP, ADP and citrate, releasing bound Mg2+ and increasing the [Mg2+]free. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 61-64 7787099-5 1995 Such a mechanism can explain a number of experimental observations, including the kinetics of ATP hydrolysis, the nucleotide dependence of Pi exchange into ATP, and the formation of stable myosin.ADP.vanadate complexes in muscle fibers. Adenosine Diphosphate 196-199 myosin, heavy chain 15 Gallus gallus 189-195 7862666-1 1995 Glutathione (GSH) synthetase [gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming), EC 6.3.2.3], an enzyme present in almost all cells, catalyzes the ATP-dependent synthesis of GSH from gamma-L-glutamyl-L-cysteine and glycine. Adenosine Diphosphate 74-77 glutathione synthetase Rattus norvegicus 0-28 7986196-6 1994 C5a was less effective than fMLP in enhancing cholera toxin-catalysed ADP-ribosylation of Gi alpha 2 and Gi alpha 3, and LTB4 was ineffective. Adenosine Diphosphate 70-73 G protein subunit alpha i3 Homo sapiens 90-115 7896756-14 1994 For other ATP analogues (dATP, ADP, and dADP), similar spectral changes were observed, and their Kd values ranged from 19 to 54 microM. Adenosine Diphosphate 31-34 ATPase Escherichia coli 10-13 8078883-0 1994 Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio. Adenosine Diphosphate 198-201 mitochondrially encoded ATP synthase 6 Homo sapiens 52-56 8078883-1 1994 A point mutation in the mtDNA-encoded ATP6 gene (T-->G at nt 8993) associated with Leigh syndrome in two pedigrees was found to decrease ADP-stimulated (state III) respiration and the ratio of ADP molecules phosphorylated to oxygen atoms reduced (ADP/O ratio) but did not affect 2,4-dinitrophenol (DNP)-uncoupled respiration, suggesting a defective mitochondrial H(+)-translocating ATP synthase. Adenosine Diphosphate 140-143 mitochondrially encoded ATP synthase 6 Homo sapiens 38-42 8078883-1 1994 A point mutation in the mtDNA-encoded ATP6 gene (T-->G at nt 8993) associated with Leigh syndrome in two pedigrees was found to decrease ADP-stimulated (state III) respiration and the ratio of ADP molecules phosphorylated to oxygen atoms reduced (ADP/O ratio) but did not affect 2,4-dinitrophenol (DNP)-uncoupled respiration, suggesting a defective mitochondrial H(+)-translocating ATP synthase. Adenosine Diphosphate 196-199 mitochondrially encoded ATP synthase 6 Homo sapiens 38-42 8078883-1 1994 A point mutation in the mtDNA-encoded ATP6 gene (T-->G at nt 8993) associated with Leigh syndrome in two pedigrees was found to decrease ADP-stimulated (state III) respiration and the ratio of ADP molecules phosphorylated to oxygen atoms reduced (ADP/O ratio) but did not affect 2,4-dinitrophenol (DNP)-uncoupled respiration, suggesting a defective mitochondrial H(+)-translocating ATP synthase. Adenosine Diphosphate 196-199 mitochondrially encoded ATP synthase 6 Homo sapiens 38-42 7913554-2 1994 The interaction of the oligomeric bacterial chaperonin GroEL and its cochaperonin, GroES, in the presence of adenosine diphosphate (ADP) forms an asymmetric complex. Adenosine Diphosphate 109-130 heat shock protein family E (Hsp10) member 1 Homo sapiens 83-88 7913554-2 1994 The interaction of the oligomeric bacterial chaperonin GroEL and its cochaperonin, GroES, in the presence of adenosine diphosphate (ADP) forms an asymmetric complex. Adenosine Diphosphate 132-135 heat shock protein family E (Hsp10) member 1 Homo sapiens 83-88 8130215-7 1994 The rate of phosphorylation by ATP is unaffected by jasmone, and only small effects are seen on the reaction of the phosphorylated ATPase with ADP. Adenosine Diphosphate 143-146 dynein axonemal heavy chain 8 Homo sapiens 131-137 7913789-2 1994 The results show that: Thrombin (0.5 U/ml) and ADP (50 mumol/L) stimulate actin polymerization in pig platelets: Adenosine, 5"-chloro-5"-deoxyadenosine, 2"-deoxyadenosine strongly inhibit thrombin- and/or ADP-induced actin polymerization. Adenosine Diphosphate 47-50 coagulation factor II, thrombin Sus scrofa 188-196 7913789-2 1994 The results show that: Thrombin (0.5 U/ml) and ADP (50 mumol/L) stimulate actin polymerization in pig platelets: Adenosine, 5"-chloro-5"-deoxyadenosine, 2"-deoxyadenosine strongly inhibit thrombin- and/or ADP-induced actin polymerization. Adenosine Diphosphate 205-208 coagulation factor II, thrombin Sus scrofa 23-31 8294444-1 1994 Although the site-directed C73S mutation in the ADP/ATP carrier (AAC) AAC2 gene from Saccharomyces cerevisiae produced a glycerol-positive strain, indicating that the mutant AAC is active, on isolation and reconstitution in egg yolk phosphatidylcholine, the C73S AAC had no transport activity, whereas the wild-type AAC was fully active. Adenosine Diphosphate 48-51 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 70-74 8821708-7 1994 When 21-kD MBP was ADP-ribosylated by chicken transferase, the potential for phospholipid vesicle aggregation was reduced in proportion of the degree of ADP-ribosylation. Adenosine Diphosphate 19-22 myelin basic protein Gallus gallus 11-14 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family E (Hsp10) member 1 Homo sapiens 0-5 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family E (Hsp10) member 1 Homo sapiens 78-83 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family E (Hsp10) member 1 Homo sapiens 78-83 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 206-209 heat shock protein family E (Hsp10) member 1 Homo sapiens 0-5 7901770-3 1993 Upon ADP-ATP exchange, GroES reassociates with GroEL and ATP hydrolysis discharges the bound protein for folding. Adenosine Diphosphate 5-8 heat shock protein family E (Hsp10) member 1 Homo sapiens 23-28 8394125-9 1993 We interpreted the ADP-induced transition between different conduction states of the ATPase from "slipping" to "closed" to "coupled" as a consequence of the alternating site mechanism of catalysis. Adenosine Diphosphate 19-22 dynein axonemal heavy chain 8 Homo sapiens 85-91 8344425-1 1993 The interactions between ADP and Mg2+ that result in the slowly reversible inhibition of the mitochondrial F1-F0 ATPase were studied. Adenosine Diphosphate 25-28 dynein axonemal heavy chain 8 Homo sapiens 113-119 8325838-4 1993 Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS. Adenosine Diphosphate 69-72 dual specificity phosphatase 2 Homo sapiens 270-274 8325838-4 1993 Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS. Adenosine Diphosphate 69-72 ral guanine nucleotide dissociation stimulator Homo sapiens 280-284 8509398-2 1993 In the absence of ATP, PT exhibited an approximately 20-fold lower linear velocity than the recombinant S1 subunit (rS1) in catalyzing the ADP-ribosylation of Gt. Adenosine Diphosphate 139-142 retinoschisin 1 Rattus norvegicus 104-106 8509398-2 1993 In the absence of ATP, PT exhibited an approximately 20-fold lower linear velocity than the recombinant S1 subunit (rS1) in catalyzing the ADP-ribosylation of Gt. Adenosine Diphosphate 139-142 retinoschisin 1 Rattus norvegicus 116-119 8485145-5 1993 Like native kinesin, K401 when purified contained ADP tightly bound at its active site, and the release of ADP from the active site occurred at a rate equal to the steady-state ATPase kcat. Adenosine Diphosphate 50-53 Kinesin heavy chain Drosophila melanogaster 12-19 8485145-5 1993 Like native kinesin, K401 when purified contained ADP tightly bound at its active site, and the release of ADP from the active site occurred at a rate equal to the steady-state ATPase kcat. Adenosine Diphosphate 107-110 Kinesin heavy chain Drosophila melanogaster 12-19 8498566-7 1993 ADP (0-250 microM) activated cytosolic 5"-nucleotidase by increasing maximal velocity and affinity for AMP. Adenosine Diphosphate 0-3 5'-nucleotidase ecto Canis lupus familiaris 39-54 7682390-2 1993 Both this ADP-ribosylation reaction and granulocytic differentiation in response to recombinant G-CSF were inhibited approximately 50% by 2 mM benzamide, suggesting a correlation between these two processes. Adenosine Diphosphate 10-13 peripheral blood stem cell response to granulocyte colony stimulating factor 1 Mus musculus 96-101 11714894-4 2001 The interaction of HMR 1883 with the SUR2 subtypes was more sensitive to inhibition by MgATP and MgADP than that of glibenclamide. Adenosine Diphosphate 97-102 ATP binding cassette subfamily C member 9 Homo sapiens 37-41 7680658-0 1993 Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho. Adenosine Diphosphate 69-72 integrin subunit alpha L Homo sapiens 27-32 11690631-4 2001 Using overexpression in COS-7 cells we showed that mcN-I, like the previously cloned pigeon cN-I, is activated by ADP and catalyses adenosine formation during ATP breakdown. Adenosine Diphosphate 114-117 5'-nucleotidase, cytosolic IA Homo sapiens 52-56 8457847-3 1993 Derivation of intracellular pH (pHi) allowed calculation of "free" ADP (ADPf) and AMP (AMPf) concentrations. Adenosine Diphosphate 67-70 glucose-6-phosphate isomerase Homo sapiens 32-35 11527389-1 2001 To characterize structural features of the regions of the yeast type 2 ADP/ATP carrier (yAAC2) facing the cytosol, we prepared its Cys-less mutant, in which all four cysteine residues were replaced by alanine residues. Adenosine Diphosphate 71-74 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 88-93 8381105-3 1993 In the presence of an inhibitor of ecto-5"-nucleotidase [alpha, beta-methylene-adenosine 5"-diphosphate (ADP), 0.5 mM], exposure to xanthine oxidase and hypoxanthine resulted in the appearance of three times more nucleotides in the culture medium than in the absence of the inhibitor, but there was no change in medium nucleotides after H2O2 exposure. Adenosine Diphosphate 105-108 5'-nucleotidase ecto Homo sapiens 35-55 8293040-4 1993 We report here that CSA causes increased ADP-stimulated aggregation in isolated platelet suspensions indicating that CSA has a direct effect on platelet function, independent of CSA interactions with plasma factors. Adenosine Diphosphate 41-44 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 20-23 8293040-4 1993 We report here that CSA causes increased ADP-stimulated aggregation in isolated platelet suspensions indicating that CSA has a direct effect on platelet function, independent of CSA interactions with plasma factors. Adenosine Diphosphate 41-44 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 117-120 8293040-4 1993 We report here that CSA causes increased ADP-stimulated aggregation in isolated platelet suspensions indicating that CSA has a direct effect on platelet function, independent of CSA interactions with plasma factors. Adenosine Diphosphate 41-44 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 117-120 8293040-5 1993 Maximal hyperaggregability of ADP-stimulated platelets occurred following a 1 h preincubation period with CSA. Adenosine Diphosphate 30-33 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 106-109 8293040-8 1993 Preincubation with CSA resulted in a 200% increase in the phosphorylation of these proteins in platelets stimulated with ADP. Adenosine Diphosphate 121-124 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 19-22 8293040-9 1993 We conclude that CSA enhances ADP-induced platelet aggregation and secretion, in part, by potentiating the phosphorylative response of specific intracellular proteins to stimulation by agonists. Adenosine Diphosphate 30-33 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 17-20 8384527-4 1993 5"-Nucleotidase activity is reported to increase adenosine production through accumulation of ATP, ADP, H+, Mg2+ and inorganic phosphate during ischaemia. Adenosine Diphosphate 99-102 5'-nucleotidase ecto Homo sapiens 0-15 1464585-3 1992 PC12 cells grown in the absence of nerve growth factor (NGF) contained ADP, ATP, GDP, and GTP at levels consistent with the actin and tubulin content of the cytoskeletal fraction. Adenosine Diphosphate 71-74 nerve growth factor Rattus norvegicus 56-59 1545407-8 1992 Pretreatment of the platelets with creatine phosphate/creatine phosphokinase (CP/CPK), which removes secreted ADP, produced 100% inhibition of IP3-induced aggregation, 90% inhibition of Ca++ mobilization and 72% inhibition of secretion. Adenosine Diphosphate 110-113 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 81-84 1530814-8 1992 The ADP scavengers apyrase and CP/CK each prevented the [Ca2+]i increase, and aggregation caused by plasmin or rt-PA, and also prevented their inhibitory effects on thrombin-induced activation. Adenosine Diphosphate 4-7 plasminogen Homo sapiens 100-107 1665598-4 1991 The ADP scavengers apyrase or CP/CPK, added in vitro to platelet suspensions obtained before ticlopidine, caused the same pattern of aggregation and 125I-fibrinogen binding inhibition as did ticlopidine. Adenosine Diphosphate 4-7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 33-36 1835657-8 1991 This small perturbation by high calcium concentrations of the observed dissociation kinetics was attributed to ADP-facilitated rapid exchange of 40Ca2+ for Mg2+ at the catalytic site of phosphorylated ATPase. Adenosine Diphosphate 111-114 dynein axonemal heavy chain 8 Homo sapiens 201-207 1667626-1 1991 We describe a new enzymatic determination of urinary guanidinoacetic acid (GAA) with guanidinoacetate kinase (ATP: guanidinoacetate N-phosphotransferase, EC 2.7.3.1), which does not require a blank to correct for endogenous constituents (ADP and pyruvate). Adenosine Diphosphate 238-241 alpha glucosidase Homo sapiens 75-78 1667626-2 1991 In the first step, pyruvate kinase (ATP: pyruvate 2-O-phosphotransferase, EC 2.7.1.40) and lactate dehydrogenase (L-lactate: NAD+ oxidoreductase, EC 1.1.1.27) were used to eliminate endogenous constituents (ADP and pyruvate) in the presence of phosphoenolpyruvate and NADH. Adenosine Diphosphate 207-210 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 130-144 1667626-3 1991 In the second step, urinary GAA was phosphorylated in the presence of ATP by guanidinoacetate kinase to form phosphoguanidinoacetate and ADP. Adenosine Diphosphate 137-140 alpha glucosidase Homo sapiens 28-31 1717069-7 1991 When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not. Adenosine Diphosphate 67-70 ral guanine nucleotide dissociation stimulator Homo sapiens 125-129 1918143-1 1991 In Saccharomyces cerevisiae the ras-related protein Rho1p is essentially the only target for ADP-ribosylation by exoenzyme C3 of Clostridium botulinum. Adenosine Diphosphate 93-96 Rho family GTPase RHO1 Saccharomyces cerevisiae S288C 52-57 1915842-1 1991 All three genes (AAC1, AAC2 and AAC3) encoding the mitochondrial ADP/ATP translocator, were inactivated in a haploid yeast strain by a gene disruption technique. Adenosine Diphosphate 65-68 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 23-27 1648963-1 1991 ATP synthesis by the membrane-bound chloroplast ATPase in the oxidized state of its gamma disulfide bridge was studied as a function of the ADP concentration, delta pH, and external pH values, under conditions where delta pH was clamped and delocalized. Adenosine Diphosphate 140-143 dynein axonemal heavy chain 8 Homo sapiens 48-54 1724587-5 1991 Recent data on the existence of auto-antibodies against the ADP/ATP translocator of the mitochondrial membrane and of stimulatory acting autoantibodies against i) the L-type calcium channel and ii) the beta 1-adrenoceptor, respectively, in patients with dilated cardiomyopathy, may open a new view in the etiology of heart failure and for consequences in the therapeutic concept of these diseases. Adenosine Diphosphate 60-63 adrenoceptor beta 1 Homo sapiens 202-221 1965685-4 1990 On the basis of the obtained results it was assumed that a part of ESP signal attributed to ADP radicals was increased during ATP synthesis. Adenosine Diphosphate 92-95 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 67-70 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 139-161 endothelin-2 Oryctolagus cuniculus 35-39 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 163-166 endothelin-2 Oryctolagus cuniculus 35-39 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 252-255 endothelin-2 Oryctolagus cuniculus 35-39 2271317-0 1990 [ADP in the NSF. Adenosine Diphosphate 1-4 N-ethylmaleimide sensitive factor, vesicle fusing ATPase Homo sapiens 12-15 2144286-1 1990 The reaction of N-ethylmaleimide (NEM) with Cys-532 of the Neurospora plasma membrane [H+]ATPase results in inhibition of ATP hydrolysis which is protected by MgADP (Pardo, J. P., and Slayman, C. W. (1989) J. Biol. Adenosine Diphosphate 159-164 dynein axonemal heavy chain 8 Homo sapiens 90-96 2168523-3 1990 We find that actin filaments made from ATP-containing monomers, the ATPase activity of which hydrolyses ATP to ADP following polymerization, are stiff rods, whereas filaments prepared from ADP-monomers are flexible. Adenosine Diphosphate 111-114 ATPase phospholipid transporting 8A2 Homo sapiens 39-42 2168523-3 1990 We find that actin filaments made from ATP-containing monomers, the ATPase activity of which hydrolyses ATP to ADP following polymerization, are stiff rods, whereas filaments prepared from ADP-monomers are flexible. Adenosine Diphosphate 111-114 dynein axonemal heavy chain 8 Homo sapiens 68-74 2168523-3 1990 We find that actin filaments made from ATP-containing monomers, the ATPase activity of which hydrolyses ATP to ADP following polymerization, are stiff rods, whereas filaments prepared from ADP-monomers are flexible. Adenosine Diphosphate 111-114 ATPase phospholipid transporting 8A2 Homo sapiens 68-71 2168523-3 1990 We find that actin filaments made from ATP-containing monomers, the ATPase activity of which hydrolyses ATP to ADP following polymerization, are stiff rods, whereas filaments prepared from ADP-monomers are flexible. Adenosine Diphosphate 189-192 dynein axonemal heavy chain 8 Homo sapiens 68-74 2168523-3 1990 We find that actin filaments made from ATP-containing monomers, the ATPase activity of which hydrolyses ATP to ADP following polymerization, are stiff rods, whereas filaments prepared from ADP-monomers are flexible. Adenosine Diphosphate 189-192 ATPase phospholipid transporting 8A2 Homo sapiens 68-71 2168523-4 1990 ATP exchanges with ADP in such filaments and stiffens them. Adenosine Diphosphate 19-22 ATPase phospholipid transporting 8A2 Homo sapiens 0-3 2168523-5 1990 Because both kinds of actin filaments contain mainly ADP, we suggest the alignment of actin monomers in filaments that have bound and hydrolysed ATP traps them conformationally and stores elastic energy. Adenosine Diphosphate 53-56 ATPase phospholipid transporting 8A2 Homo sapiens 145-148 2144402-5 1990 The Km ADP for myofibrillar CK from control and stunned hearts was 60.45 +/- 3.45 and 68.04 +/- 2.42 microM, respectively, and the CK activity at 100 microM ADP was 0.63 +/- 0.08 and 0.67 +/- 0.04 IU/mg myofibrillar protein from control and stunned hearts, a rate three times greater than the myofibrillar adenosinetriphosphatase (ATPase) rate and a rate sufficient to deliver ATP to the myofilaments. Adenosine Diphosphate 7-10 potassium-transporting ATPase alpha chain 1 Oryctolagus cuniculus 331-337 2167308-3 1990 The gene encoding the major ADP/ATP carrier in yeast AAC2 (pet9; Lawson, J., and Douglas, M. (1988) J. Biol. Adenosine Diphosphate 28-31 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 53-57 2167308-3 1990 The gene encoding the major ADP/ATP carrier in yeast AAC2 (pet9; Lawson, J., and Douglas, M. (1988) J. Biol. Adenosine Diphosphate 28-31 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 59-63 2167309-3 1990 AAC1 and AAC2 genes in yeast each encode functional ADP/ATP carrier (AAC) proteins of the mitochondrial inner membrane. Adenosine Diphosphate 52-55 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 9-13 2359406-1 1990 In the presence of Mg2+, pure glutamate dehydrogenase is more reactive with NADPH than with NADH and is markedly activated by elevations in the ADP/ATP ratio or the addition of leucine. Adenosine Diphosphate 77-80 mucin 7, secreted Homo sapiens 19-22 2359406-3 1990 In the absence of the allosteric activators ADP, leucine, or succinyl-CoA, Mg2+ is an inhibitor and increases product inhibition by alpha-ketoglutarate in the forward reaction and substrate inhibition by alpha-ketoglutarate in the reverse reaction. Adenosine Diphosphate 44-47 mucin 7, secreted Homo sapiens 75-78 2359406-5 1990 In the reverse reaction, ADP also converts Mg2+ from an inhibitor into an activator and leucine eliminates inhibition by Mg2+. Adenosine Diphosphate 25-28 mucin 7, secreted Homo sapiens 43-46 2359406-5 1990 In the reverse reaction, ADP also converts Mg2+ from an inhibitor into an activator and leucine eliminates inhibition by Mg2+. Adenosine Diphosphate 25-28 mucin 7, secreted Homo sapiens 121-124 2140359-6 1990 If the reaction is reversed (toward ATP synthesis) 70% of the phosphoenzyme is ADP-sensitive and ADP-induced dephosphorylation is fast (k-2 = 15 s-1), whereas the ADP-insensitive phosphoenzyme slowly hydrolyzes in the forward direction of the ATPase cycle at a rate of 0.05 s-1. Adenosine Diphosphate 79-82 dynein axonemal heavy chain 8 Homo sapiens 243-249 2140359-6 1990 If the reaction is reversed (toward ATP synthesis) 70% of the phosphoenzyme is ADP-sensitive and ADP-induced dephosphorylation is fast (k-2 = 15 s-1), whereas the ADP-insensitive phosphoenzyme slowly hydrolyzes in the forward direction of the ATPase cycle at a rate of 0.05 s-1. Adenosine Diphosphate 97-100 dynein axonemal heavy chain 8 Homo sapiens 243-249 2140359-6 1990 If the reaction is reversed (toward ATP synthesis) 70% of the phosphoenzyme is ADP-sensitive and ADP-induced dephosphorylation is fast (k-2 = 15 s-1), whereas the ADP-insensitive phosphoenzyme slowly hydrolyzes in the forward direction of the ATPase cycle at a rate of 0.05 s-1. Adenosine Diphosphate 97-100 dynein axonemal heavy chain 8 Homo sapiens 243-249 11511514-3 2001 When platelets from mice lacking the G protein-activated PI3Kgamma isoform were stimulated with ADP, aggregation was impaired. Adenosine Diphosphate 96-99 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 57-66 2361136-6 1990 Addition of ADP to initiate state 3 respiration causes a marked increase in free matrix Mg2+ (0.1-0.2 mM) that persists as long as ATP formation is taking place; free Mg2+ then returns to the base level. Adenosine Diphosphate 12-15 mucin 7, secreted Homo sapiens 88-91 2361136-6 1990 Addition of ADP to initiate state 3 respiration causes a marked increase in free matrix Mg2+ (0.1-0.2 mM) that persists as long as ATP formation is taking place; free Mg2+ then returns to the base level. Adenosine Diphosphate 12-15 mucin 7, secreted Homo sapiens 167-170 2361136-8 1990 Exchange of external ADP for matrix ATP may also contribute to the increase in free matrix Mg2+. Adenosine Diphosphate 21-24 mucin 7, secreted Homo sapiens 91-94 2361136-10 1990 Similar changes in free Mg2+ on addition of Pi, ADP, or uncoupler are seen when extramitochondrial Mg2+ is buffered from 0.5 to 2 mM, but the basal free matrix Mg2+ increases as external Mg2+ concentration increases in this range. Adenosine Diphosphate 48-51 mucin 7, secreted Homo sapiens 24-27 2361136-10 1990 Similar changes in free Mg2+ on addition of Pi, ADP, or uncoupler are seen when extramitochondrial Mg2+ is buffered from 0.5 to 2 mM, but the basal free matrix Mg2+ increases as external Mg2+ concentration increases in this range. Adenosine Diphosphate 48-51 mucin 7, secreted Homo sapiens 99-102 2361136-10 1990 Similar changes in free Mg2+ on addition of Pi, ADP, or uncoupler are seen when extramitochondrial Mg2+ is buffered from 0.5 to 2 mM, but the basal free matrix Mg2+ increases as external Mg2+ concentration increases in this range. Adenosine Diphosphate 48-51 mucin 7, secreted Homo sapiens 99-102 2361136-10 1990 Similar changes in free Mg2+ on addition of Pi, ADP, or uncoupler are seen when extramitochondrial Mg2+ is buffered from 0.5 to 2 mM, but the basal free matrix Mg2+ increases as external Mg2+ concentration increases in this range. Adenosine Diphosphate 48-51 mucin 7, secreted Homo sapiens 99-102 11511514-5 2001 ADP stimulation of PI3Kgamma-deficient platelets resulted in decreased PKB/Akt phosphorylation and alpha(IIb)beta(3) fibrinogen receptor activation. Adenosine Diphosphate 0-3 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 19-28 11511514-6 2001 These effects did not influence bleeding time but protected PI3Kgamma-null mice from death caused by ADP-induced platelet-dependent thromboembolic vascular occlusion. Adenosine Diphosphate 101-104 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 60-69 2107277-5 1990 Both Go alpha isoforms have similar sizes on sodium dodecyl sulfate-polyacrylamide gels, are recognized by polyclonal antibodies to bovine brain Go alpha, are ADP-ribosylated by PTX, and are covalently myristylated in whole N1E-115 cells. Adenosine Diphosphate 159-162 guanine nucleotide binding protein, alpha O Mus musculus 5-13 2303447-2 1990 Incubation of human erythrocytes oxidized by iron catalysts, ADP/Fe3+ or xanthine/xanthine oxidase/Fe3+, with autologous IgG resulted in IgG binding as detected by enzyme immunoassay using protein A-beta-galactosidase conjugate. Adenosine Diphosphate 61-64 galactosidase beta 1 Homo sapiens 199-217 11511514-7 2001 This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy. Adenosine Diphosphate 87-90 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 63-72 11511514-7 2001 This result demonstrates an unsuspected, well-defined role for PI3Kgamma downstream of ADP and suggests that pharmacological targeting of PI3Kgamma has a potential use as antithrombotic therapy. Adenosine Diphosphate 87-90 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 138-147 2140357-1 1990 An intrinsic ATPase inhibitor inhibits the ATP-hydrolyzing activity of mitochondrial F1F0-ATPase and is released from its binding site on the enzyme upon energization of mitochondrial membranes to allow phosphorylation of ADP. Adenosine Diphosphate 222-225 dynein axonemal heavy chain 8 Homo sapiens 13-19 2140357-1 1990 An intrinsic ATPase inhibitor inhibits the ATP-hydrolyzing activity of mitochondrial F1F0-ATPase and is released from its binding site on the enzyme upon energization of mitochondrial membranes to allow phosphorylation of ADP. Adenosine Diphosphate 222-225 dynein axonemal heavy chain 8 Homo sapiens 90-96 11577458-6 2001 Much higher concentrations of ADP were necessary to activate channels which SUR1 or SUR2B. Adenosine Diphosphate 30-33 ATP binding cassette subfamily C member 8 Homo sapiens 76-80 11395509-3 2001 In particular, the changes elicited by ADP.AlF(3) provide insights into the mechanism of ATP hydrolysis. Adenosine Diphosphate 39-42 ATPase Escherichia coli 89-92 2137348-7 1990 The Mg2(+)- and ADP-inhibited enzyme when exposed to MgATP and 20-100 mM sulfite shows a lag of about 1 min at 22 degrees C and of about 15 s at 37 degrees C before reaching the same steady-state rate as attained with light-activated ATPase that has not been inhibited by Mg2+ and ADP. Adenosine Diphosphate 281-284 dynein axonemal heavy chain 8 Homo sapiens 234-240 2137348-9 1990 The release of most of the bound [3H]ADP parallels the onset of ATPase activity, although some [3H]ADP is not released even with prolonged catalytic turnover and may be on poorly active or inactive enzyme or at noncatalytic sites. Adenosine Diphosphate 37-40 dynein axonemal heavy chain 8 Homo sapiens 64-70 2136738-5 1990 Binding of ATP and ADP enhanced the intrinsic fluorescence of sarcoplasmic reticulum ATPase, but AMP and adenosine did not affect it. Adenosine Diphosphate 19-22 dynein axonemal heavy chain 8 Homo sapiens 85-91 11502255-7 2001 Nucleotide exchange between intrinsic ATPase and ATP/ADP-scavenging systems defined the lifetimes of specific SUR conformations gating K(ATP) channels. Adenosine Diphosphate 53-56 ATP binding cassette subfamily C member 8 Homo sapiens 110-113 2085655-7 1990 To explain this, it was suggested that the fluorescence anisotropy decay of the PGK-MgADP complex corresponded to the rotation of the only buried tryptophan (Trp 335). Adenosine Diphosphate 84-89 phosphoglycerate kinase Saccharomyces cerevisiae S288C 80-83 11387196-6 2001 This could weaken Mg2+ binding and accelerate ADP release to activate the motor ATPASE: The structural changes we observe define a signaling pathway within the motor for ATPase activation that is likely to be essential for motor movement on microtubules. Adenosine Diphosphate 46-49 dynein axonemal heavy chain 8 Homo sapiens 80-86 2327288-5 1990 The addition of EGF to fetal brain slices causes a significant increase of ADP-ribosylation of total histones (particularly of the histone H1 fraction) and also of NHPs and microsomal proteins. Adenosine Diphosphate 75-78 epidermal growth factor like 1 Rattus norvegicus 16-19 2140894-2 1990 The involvement of dansylated ATP, ADP and AMP as substrate analogues in energy metabolism is demonstrated in the ATPase, hexokinase, pyruvate kinase and adenylate kinase reactions. Adenosine Diphosphate 35-38 dynein axonemal heavy chain 8 Homo sapiens 114-120 11387196-6 2001 This could weaken Mg2+ binding and accelerate ADP release to activate the motor ATPASE: The structural changes we observe define a signaling pathway within the motor for ATPase activation that is likely to be essential for motor movement on microtubules. Adenosine Diphosphate 46-49 dynein axonemal heavy chain 8 Homo sapiens 170-176 11413167-5 2001 Recently, we cloned a human orphan receptor, SP1999, highly expressed in brain and platelets, which responded to ADP and had a pharmacological profile similar to that of P2Y12. Adenosine Diphosphate 113-116 purinergic receptor P2Y12 Homo sapiens 45-51 33819246-1 2021 Antagonists of the Adenosine Diphosphate (ADP) receptor, P2Y12, may inhibit platelet aggregation as a result of stimulation with arachidonic acid (AA). Adenosine Diphosphate 42-45 purinergic receptor P2Y12 Homo sapiens 57-62 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 114-135 patatin-like phospholipase domain containing 8 Mus musculus 62-72 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 137-140 patatin-like phospholipase domain containing 8 Mus musculus 62-72 25313821-3 2014 In this study, we found that group VIB Ca2+-independent PLA2 (iPLA2gamma)-deficient platelets showed decreases in adenosine diphosphate (ADP)-dependent aggregation and ADP- or collagen-dependent thromboxane A2 production. Adenosine Diphosphate 168-171 patatin-like phospholipase domain containing 8 Mus musculus 62-72 25313821-6 2014 These results suggest that iPLA2gamma is an additional, long-sought-after PLA2 that hydrolyzes platelet membranes and facilitates platelet aggregation in response to ADP. Adenosine Diphosphate 166-169 patatin-like phospholipase domain containing 8 Mus musculus 27-37 11454258-5 2001 As a result of the plasmapheresis on the Autopherese C, the mean closure time (CT) for collagen/epinephrine (Col/Epi) increased from 118.2 +/- 25.1 to 149.9 +/- 35.0 s and from 88.7 +/- 16.9 to 98.5 +/- 26.3 s for collagen/ADP (Col/ADP), respectively. Adenosine Diphosphate 223-226 tissue factor pathway inhibitor Homo sapiens 109-116 34922916-4 2022 Here, CD39 first converts ATP and adenosine diphosphate(ADP) into AMP, after which AMP is dephosphorylated into adenosine by CD73. Adenosine Diphosphate 56-59 5'-nucleotidase ecto Homo sapiens 125-129 11454258-5 2001 As a result of the plasmapheresis on the Autopherese C, the mean closure time (CT) for collagen/epinephrine (Col/Epi) increased from 118.2 +/- 25.1 to 149.9 +/- 35.0 s and from 88.7 +/- 16.9 to 98.5 +/- 26.3 s for collagen/ADP (Col/ADP), respectively. Adenosine Diphosphate 232-235 tissue factor pathway inhibitor Homo sapiens 109-116 34961895-9 2022 Our study identifies human CD73 as target for ARTC1-mediated mono-ADP-ribosylation, which can profoundly modulate its adenosine-generating activity. Adenosine Diphosphate 66-69 5'-nucleotidase ecto Homo sapiens 27-31 11154698-9 2001 We have now determined high resolution (1.8 A) crystal structures for EDN in complex with adenosine-3",5"-diphosphate (3",5"-ADP), adenosine-2",5"-di-phosphate (2",5"-ADP), adenosine-5"-diphosphate (5"-ADP) as well as for a native structure in the presence of sulfate refined at 1.6 A. Adenosine Diphosphate 173-197 ribonuclease A family member 2 Homo sapiens 70-73 34944680-5 2021 In EndoC-betaH1 cells, NOX4 inhibition increased the mitochondrial membrane potential, as estimated by JC-1 fluorescence; mitochondrial reactive oxygen species (ROS) production, as estimated by MitoSOX fluorescence; and the ATP/ADP ratio, as assessed by a bioluminescent assay. Adenosine Diphosphate 228-231 NADPH oxidase 4 Homo sapiens 23-27 34878641-8 2022 RESULTS: Significant correlations (r = 0.19-0.55, p < .05) with AMPK activity were found between end-exercise muscle glycogen, exercise intensity, and muscle metabolites phosphocreatine, creatine, and free ADP. Adenosine Diphosphate 206-209 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 64-68 11136735-11 2001 Comparison to the homologous mutants of yeast AAC2 permits attribution of the roles of these residues more to ADP/ATP transport or to AAC import into mitochondria. Adenosine Diphosphate 110-113 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 46-50 34874266-0 2021 Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. Adenosine Diphosphate 7-10 chromodomain helicase DNA binding protein 1 like Homo sapiens 46-50 34860335-8 2021 In the candidate gene analysis, rs7830 (NOS3) was associated with both ADP aggregation rate and 18- and 30-month ISR, and rs 62,275,847 (AGTR1) was associated with both ADP aggregation rate and 30-month ISR. Adenosine Diphosphate 169-172 angiotensin II receptor type 1 Homo sapiens 137-142 11239719-6 2001 However, there was a significant decrease in adenosine diphosphate (ADP) hydrolysis in both hippocampal (-39%) and cortical (-25%) synaptosomes in PrP(c) null animals compared to wild-type mice. Adenosine Diphosphate 45-66 prion protein Mus musculus 147-153 34697820-3 2021 CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine. Adenosine Diphosphate 124-127 5'-nucleotidase ecto Homo sapiens 194-214 34697820-3 2021 CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine. Adenosine Diphosphate 124-127 5'-nucleotidase ecto Homo sapiens 216-220 11239719-6 2001 However, there was a significant decrease in adenosine diphosphate (ADP) hydrolysis in both hippocampal (-39%) and cortical (-25%) synaptosomes in PrP(c) null animals compared to wild-type mice. Adenosine Diphosphate 68-71 prion protein Mus musculus 147-153 11102441-6 2001 Pro-caspase-8 and cytochrome c were released from isolated mitochondria that were treated with an inhibitor of the ADP/ATP carrier atractyloside, which opens the mitochondria permeability transition pore. Adenosine Diphosphate 115-118 caspase 8 Homo sapiens 4-13 11104774-0 2001 ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 68-74 34748820-5 2021 METHODS: We measured platelet P2Y12 expression and aggregation in response to ADP in septic patients and cecal ligation and puncture (CLP)-treated mice. Adenosine Diphosphate 78-81 purinergic receptor P2Y12 Homo sapiens 30-35 11104774-10 2001 ADP was subsequently shown to inhibit forskolin-stimulated adenylyl cyclase activity through selective activation of SP1999 with an EC(50) of 60 nM. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 117-123 11104774-11 2001 Other nucleotides were able to activate SP1999 with a rank order of potency 2-MeS-ATP = 2-MeS-ADP > ADP = adenosine 5"-O-2-(thio)diphosphate > 2-Cl-ATP > adenosine 5"-O-(thiotriphosphate). Adenosine Diphosphate 94-97 purinergic receptor P2Y12 Homo sapiens 40-46 11067849-7 2001 Thus, in the ATPase catalytic cycle, an intrinsically transient phosphorylated species with transport sites occupied but not yet occluded must also have been stabilized by fluorescein isothiocyanate (FITC), possibly mimicking ADP. Adenosine Diphosphate 226-229 dynein axonemal heavy chain 8 Homo sapiens 13-19 34403084-4 2021 Interestingly, ADP and ATP are competitive inhibitors of CD73, with the most potent small-molecule inhibitors to date being non-hydrolysable ADP analogues. Adenosine Diphosphate 15-18 5'-nucleotidase ecto Homo sapiens 57-61 34403084-4 2021 Interestingly, ADP and ATP are competitive inhibitors of CD73, with the most potent small-molecule inhibitors to date being non-hydrolysable ADP analogues. Adenosine Diphosphate 141-144 5'-nucleotidase ecto Homo sapiens 57-61 11159520-0 2001 Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function. Adenosine Diphosphate 0-21 C-C motif chemokine ligand 22 Homo sapiens 73-76 34774067-7 2021 Knockdown of STOML2 reduced glucose consumption, lactate production and ATP/ADP ratios. Adenosine Diphosphate 76-79 stomatin like 2 Homo sapiens 13-19 34320407-5 2021 A high-resolution structure of PFKL confirmed binding of NA-11 to the AMP/ADP allosteric activation site and explained why NA-11 failed to agonize phosphofructokinase-1 platelet type (PFKP) or muscle type (PFKM). Adenosine Diphosphate 74-77 phosphofructokinase, liver type Homo sapiens 31-35 11327816-12 2001 Arg(491) (in the C-terminal helix close to the GTP #2 binding domain of GDH) is thus considered to be at or near the enzyme"s allosteric ADP site. Adenosine Diphosphate 137-140 glucose dehydrogenase Bos taurus 72-75 34264286-2 2021 ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L). Adenosine Diphosphate 90-93 deltex E3 ubiquitin ligase 3L Homo sapiens 42-47 34291079-6 2021 We finally analyzed involvement of NF-kappaB signaling pathway in the release of CXCL10 in ADP-stimulated alveolar epithelial cells. Adenosine Diphosphate 91-94 chemokine (C-X-C motif) ligand 10 Mus musculus 81-87 34291079-9 2021 Furthermore, ADP stimulated alveolar epithelial cells to secrete chemokine CXCL10 by activating P2Y1 receptor, whereby promoting asthma airway inflammation. Adenosine Diphosphate 13-16 chemokine (C-X-C motif) ligand 10 Mus musculus 75-81 34291079-10 2021 Additionally, ADP activated the NF-kappaB signaling pathway to promote CXCL10 release. Adenosine Diphosphate 14-17 chemokine (C-X-C motif) ligand 10 Mus musculus 71-77 11169102-8 2001 We conclude that actin is a target for an SpvB-mediated modification, most probably ADP-ribosylation, and that the modification of G actin interferes with actin polymerization. Adenosine Diphosphate 84-87 virulence protein Salmonella enterica 42-46 34140535-6 2021 Rg1 also improved the concentration-time curve of MAO and COX and levels of ATP, ADP and AMP in an in vitro test. Adenosine Diphosphate 81-84 protein phosphatase 1, regulatory subunit 3A Mus musculus 0-3 11087368-8 2000 ADP release from the actin-myosin complex is the rate-limiting step in the ATPase cycle with all actin and light chain isoforms. Adenosine Diphosphate 0-3 dynein, axonemal, heavy chain 8 Mus musculus 75-81 34719496-8 2021 CONCLUSION: We found that reduced cortical thickness of the cACC is a predictor of aMCI conversion to AD + P, independent of HC, suggesting that the ACC plays a vital role in the underlying pathogenesis of AD + P. Adenosine Diphosphate 102-108 chloride channel accessory 1 Homo sapiens 60-64 11073882-5 2000 In inside-out patches of human embryonic kidney 293T cells coexpressing distinct SURs and Kir6.2, much higher concentrations of ADP were needed to activate channels that contained SUR2A than SUR1 or SUR2B. Adenosine Diphosphate 128-131 ATP binding cassette subfamily C member 8 Homo sapiens 191-195 34752329-2 2021 These include A1 and A2A adenosine receptors, and P2Y1 and P2Y12 receptors that respond to ADP and other nucleotides. Adenosine Diphosphate 91-94 purinergic receptor P2Y12 Homo sapiens 59-64 35523115-7 2022 RESULTS: Five quality control markers (ginsenoside Rg1, ginsenoside Rb1, tenuifolin, poricoic acid B, and alpha-asarone) were detected in the ADP solution. Adenosine Diphosphate 142-145 protein phosphatase 1, regulatory subunit 3A Mus musculus 51-54 35523115-8 2022 The ginsenoside Rg1 content in ADP was found to be 0.114 mg/g. Adenosine Diphosphate 31-34 protein phosphatase 1, regulatory subunit 3A Mus musculus 16-19 34991155-5 2022 SHARPIN-null platelets adhered to immobilized fibrinogen through alphaIIbbeta3, and they spread more extensively than littermate control platelets in a manner dependent on feedback stimulation by platelet adenosine diphosphate (ADP) (P < 0.01). Adenosine Diphosphate 228-231 SHANK-associated RH domain interacting protein Mus musculus 0-7 34991155-6 2022 SHARPIN-null platelets showed increased colocalization of alphaIIbbeta3 with talin as assessed by super-resolution microscopy and increased binding of soluble fibrinogen in response to sub-maximal concentrations of ADP (P < 0.05). Adenosine Diphosphate 215-218 SHANK-associated RH domain interacting protein Mus musculus 0-7 11073882-7 2000 Replacement of the C-terminal segment of SUR1 with that of SUR2A inhibited ADP-mediated channel activation and reduced diazoxide modulation. Adenosine Diphosphate 75-78 ATP binding cassette subfamily C member 8 Homo sapiens 41-45 11073882-8 2000 Point mutations of the second nucleotide-binding domains (NBD2) of SUR1 and SUR2B, which would prevent ADP binding or ATP hydrolysis, showed similar effects. Adenosine Diphosphate 103-106 ATP binding cassette subfamily C member 8 Homo sapiens 67-71 10893240-8 2000 2) The affinities of NBF1 of SUR1 for ATP and ADP, especially for ATP, were significantly higher than those of SUR2A and SUR2B. Adenosine Diphosphate 46-49 ATP binding cassette subfamily C member 8 Homo sapiens 29-33 35457131-3 2022 In this study, we focused on AK3, the isozyme localized in the mitochondrial matrix that reversibly mediates the following reaction: Mg2+ GTP + AMP Mg2+ GDP + ADP. Adenosine Diphosphate 161-164 adenylate kinase 3 Homo sapiens 29-32 10764784-5 2000 Surprisingly, in the presence of Mg-ADP, GroES was able to cap the GroEL-alphabeta complex in cis, despite the size of 86 kDa of the heterodimer (with a His(6) tag and a linker). Adenosine Diphosphate 33-39 heat shock protein family E (Hsp10) member 1 Homo sapiens 41-46 35384794-5 2022 Results: For boys with low PA, BMI overestimated body fat values measured by ADP (mean error = -0.42; p = .018) which also occurred in group high PA (mean error = -0.76; p = .001). Adenosine Diphosphate 77-80 FAT atypical cadherin 1 Homo sapiens 54-57 10886564-8 2000 RESULTS: Within 15 minutes, CE and CO each induced approximately 90% ATP/ADP ratio suppressions. Adenosine Diphosphate 73-76 carboxyl ester lipase Mus musculus 28-30 35041824-2 2022 The human transport protein SLC35B1 was recently postulated to mediate ATP/ADP exchange in the ER; however, the underlying molecular mechanisms mediating ATP uptake are not completely understood. Adenosine Diphosphate 75-78 solute carrier family 35 member B1 Homo sapiens 28-35 35041824-5 2022 We found that the apparent affinities of SLC35B1 for ATP/ADP on the internal face were approximately 13 times higher than those on the external side. Adenosine Diphosphate 57-60 solute carrier family 35 member B1 Homo sapiens 41-48 35041824-7 2022 Three different experimental approaches indicated that ATP/ADP exchange by SLC35B1 was not strict, and that other di- and trinucleotides could act as suitable counter-substrates for ATP, although mononucleotides and nucleotide sugars were not transported. Adenosine Diphosphate 59-62 solute carrier family 35 member B1 Homo sapiens 75-82 35041824-9 2022 The fact that SLC35B1 can promote ATP transport in exchange for ADP or UDP suggest a more direct coupling between ATP import requirements and the need for eliminating ADP and UDP, which are generated as side products of reactions taking place in the ER-lumen. Adenosine Diphosphate 64-67 solute carrier family 35 member B1 Homo sapiens 14-21 35041824-9 2022 The fact that SLC35B1 can promote ATP transport in exchange for ADP or UDP suggest a more direct coupling between ATP import requirements and the need for eliminating ADP and UDP, which are generated as side products of reactions taking place in the ER-lumen. Adenosine Diphosphate 167-170 solute carrier family 35 member B1 Homo sapiens 14-21 10727146-5 2000 The interaction of the substrate and product ADP and ATP nucleotides with the enzyme has been studied in protein complexes where Mg2+ is substituted for Mn2+. Adenosine Diphosphate 45-48 mucin 7, secreted Homo sapiens 129-132 35344129-2 2022 The current study aimed to probe into antidepressant power (ADP) of MIS in animals and confirmation of ADP with in silico induced-fit molecular docking. Adenosine Diphosphate 60-63 anti-Mullerian hormone Mus musculus 68-71 10632717-4 2000 Using this assay, we have investigated how the thermal stability of actin is affected by either Ca2 + or Mg2 + at the high affinity divalent cation binding site, by the concentration of excess nucleotide, and by the nucleotide in different states of phosphorylation (ATP, ADP.Pi, ADP. Adenosine Diphosphate 272-275 actin epsilon 1 Bos taurus 68-73 35322207-5 2022 Comparisons of the ADP-state structure with its apo-state and a substrate-engaged yeast YME1 structure show conformational changes in the ATPase domains, rather than the protease domains. Adenosine Diphosphate 19-22 i-AAA protease YME1 Saccharomyces cerevisiae S288C 88-92 10632717-4 2000 Using this assay, we have investigated how the thermal stability of actin is affected by either Ca2 + or Mg2 + at the high affinity divalent cation binding site, by the concentration of excess nucleotide, and by the nucleotide in different states of phosphorylation (ATP, ADP.Pi, ADP. Adenosine Diphosphate 280-283 actin epsilon 1 Bos taurus 68-73 35191835-5 2022 This ADP hypersensitivity, driven by increased expression of P2Y12 and P2Y13 receptors, results in greater release of Ca2+ from the endoplasmic reticulum (ER) stores, which triggers sustained Ca2+ influx through Orai channels and alters cell motility in TREM2 KO microglia. Adenosine Diphosphate 5-8 purinergic receptor P2Y12 Homo sapiens 61-66 10518593-6 1999 However, in the presence of cytoplasmic ADP (100 microM), SUR2A/Kir6.2 channels became as sensitive to diazoxide as SUR1/Kir6. Adenosine Diphosphate 40-43 ATP binding cassette subfamily C member 8 Homo sapiens 116-120 34860143-6 2022 MEASUREMENTS AND MAIN RESULTS: Aeroallergen-exposure induced the extracellular release of ADP and ATP, nucleotides that activate P2Y13-R. ATP, ADP, aeroallergen (house dust mite, cockroach or Alternaria) or virus exposure induced the nuclear-to-cytoplasmic translocation and subsequent release of IL-33 and HMGB1, and this response was ablated by genetic deletion or pharmacological antagonism of P2Y13. Adenosine Diphosphate 90-93 high mobility group box 1 Mus musculus 307-312 10518593-8 1999 This effect involved specific interactions between MgADP and SUR, as it required Mg(2+), but not ATP, and was abolished by point mutations in the second nucleotide-binding domain of SUR, which impaired channel activation by MgADP. Adenosine Diphosphate 51-56 ATP binding cassette subfamily C member 8 Homo sapiens 61-64 10518593-8 1999 This effect involved specific interactions between MgADP and SUR, as it required Mg(2+), but not ATP, and was abolished by point mutations in the second nucleotide-binding domain of SUR, which impaired channel activation by MgADP. Adenosine Diphosphate 51-56 ATP binding cassette subfamily C member 8 Homo sapiens 182-185 10518593-8 1999 This effect involved specific interactions between MgADP and SUR, as it required Mg(2+), but not ATP, and was abolished by point mutations in the second nucleotide-binding domain of SUR, which impaired channel activation by MgADP. Adenosine Diphosphate 224-229 ATP binding cassette subfamily C member 8 Homo sapiens 61-64 2551727-4 1989 The IAP-induced inhibition was correlated with the toxin-catalyzed ADP-ribosylation of a membrane GTP-binding protein with a molecular mass of 40 kDa. Adenosine Diphosphate 67-70 islet amyloid polypeptide Homo sapiens 4-7 10518593-8 1999 This effect involved specific interactions between MgADP and SUR, as it required Mg(2+), but not ATP, and was abolished by point mutations in the second nucleotide-binding domain of SUR, which impaired channel activation by MgADP. Adenosine Diphosphate 224-229 ATP binding cassette subfamily C member 8 Homo sapiens 182-185 2548588-8 1989 Kinetic studies revealed that the catalytic reaction of liver pyridoxal kinase follows an ordered mechanism in which pyridoxal and ATP bind to the enzyme and ADP and pyridoxal 5"-phosphate are released from the enzyme, in this order. Adenosine Diphosphate 158-161 pyridoxal kinase Sus scrofa 62-78 10512757-5 1999 When testing the effect of each inhibitor individually we found the strongest inhibition of thrombin-induced PtdIns(3,4)P(2) production with the ADP scavenger system CP/CPK. Adenosine Diphosphate 145-148 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 169-172 10544922-7 1999 Adenosine-5"-phosphate-3"-phosphosulfate, a P2Y1 receptor antagonist, completely blocked ADP-induced inositol 1,4,5-trisphosphate and inositol 1,3.4-trisphosphate formation suggesting that P2TAC-mediated activation of Gi (or other G proteins) does not activate phospholipase C. These results suggest that a signaling event downstream from Gi, independent of the inhibition of platelet adenylyl cyclase, contributes to alphaIIb beta3 activation. Adenosine Diphosphate 89-92 purinergic receptor P2Y12 Homo sapiens 189-194 2538071-3 1989 High-Km 5"-nucleotidase was eluted with 0.5 M NaCl, low-Km 5"-nucleotidase was eluted with 10 mM ADP, and nonspecific phosphatase was not retained on the column. Adenosine Diphosphate 97-100 5'-nucleotidase ecto Homo sapiens 59-74 2537026-2 1989 Intramuscular injection of the ADP-analogue adenosine alpha, beta-methylene diphosphate (AMP-CP) achieved a 70% reduction in 5"-nucleotidase activity, as measured in crude extracts of rat kidney. Adenosine Diphosphate 31-34 5' nucleotidase, ecto Rattus norvegicus 125-140 2912385-5 1989 ATPase activity was inhibited by ADP but not by molybdate, vanadate, azide, nitrate, or fluoride. Adenosine Diphosphate 33-36 dynein axonemal heavy chain 8 Homo sapiens 0-6 10519557-6 1999 We visualized the myosin VI construct bound to actin using cryo-electron microscopy and image analysis, and found that an ADP-mediated conformational change in the domain distal to the motor, a structure likely to be the effective lever arm, is in the opposite direction to that observed for other myosins. Adenosine Diphosphate 122-125 myosin VI Homo sapiens 18-27 2974728-4 1988 This was supported by protection experiments using ATP, ADP, AdoPP[NH]P, ITP, and TNP-ATP, all of which displayed protection constants similar to their known binding constants to the active site of the ATPase. Adenosine Diphosphate 56-59 dynein axonemal heavy chain 8 Homo sapiens 202-208 10446085-8 1999 Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. Adenosine Diphosphate 63-66 purinergic receptor P2Y12 Homo sapiens 37-44 10446085-8 1999 Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. Adenosine Diphosphate 63-66 vasodilator stimulated phosphoprotein Homo sapiens 143-147 10419475-3 1999 The ATPase was found to be regulated by a mismatch-stimulated ADP --> ATP exchange, which induces a conformational transition by the protein complex. Adenosine Diphosphate 62-65 dynein axonemal heavy chain 8 Homo sapiens 4-10 3179439-2 1988 Our data indicate that platelets activated in platelet-rich plasma (PRP) by adenosine-5"-diphosphate (ADP) or thrombin bind plasminogen to their surface. Adenosine Diphosphate 76-100 plasminogen Homo sapiens 124-135 3179439-2 1988 Our data indicate that platelets activated in platelet-rich plasma (PRP) by adenosine-5"-diphosphate (ADP) or thrombin bind plasminogen to their surface. Adenosine Diphosphate 102-105 plasminogen Homo sapiens 124-135 3179439-4 1988 Platelet aggregation and plasminogen and fibrinogen binding are also concurrently inhibited by the Gly-Arg-Asp (RGD) analogue Gly-Arg-Gly-Asp-Ser (GRGDS) when it is added to PRP before ADP stimulation. Adenosine Diphosphate 185-188 plasminogen Homo sapiens 25-36 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 116-137 dual specificity phosphatase 2 Homo sapiens 44-49 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 139-142 dual specificity phosphatase 2 Homo sapiens 44-49 2853232-8 1988 Because they bind Ca2+ needed for activation, ATP, ADP, and ITP inhibit m-calpain. Adenosine Diphosphate 51-54 calpain 2 Bos taurus 72-81 16801098-4 1999 In addition, a marked inhibition of basal VASP phosphorylation by ADP was observed. Adenosine Diphosphate 66-69 vasodilator stimulated phosphoprotein Homo sapiens 42-46 3190685-2 1988 To do this a method has been developed to continuously monitor ATP efflux from phosphorylating mitochondria caused by externally added ADP, by photometrically following the NADP+ reduction which occurs in the presence of glucose, hexokinase, glucose-6-phosphate dehydrogenase and effluxed ATP. Adenosine Diphosphate 135-138 glucose-6-phosphate dehydrogenase Rattus norvegicus 242-275 10454120-7 1999 It suggested that the partial coupling of respiration to ADP phosphorylation was due to proton leaks possibly related to the brown fat UCP. Adenosine Diphosphate 57-60 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 135-138 2972256-9 1988 Quercetin did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell. Adenosine Diphosphate 144-147 dynein, axonemal, heavy chain 8 Mus musculus 32-38 2972256-9 1988 Quercetin did, however, inhibit ATPase activity of plasma membrane, suggesting that this unidentified ATPase may contribute to the formation of ADP and Pi required for lactate production by the intact cell. Adenosine Diphosphate 144-147 dynein, axonemal, heavy chain 8 Mus musculus 102-108 10395457-6 1999 When ADP, ATP, or AMP-PNP were added to a solution of GroEL and Mg2+, C138 incorporated approximately 0.8 labels, while C458 incorporated approximately 0.1 labels. Adenosine Diphosphate 5-8 mucin 7, secreted Homo sapiens 64-67 2845933-3 1988 In combination with GTP[S], these hormones potentiate the response to GTP[S], indicating the existence of a G-protein involved in the coupling of the VP and AT II receptor with the phospholipase C. ADP-ribosylation with pertussis toxin (IAP) revealed the specific labelling of a single molecule of 41 kDa. Adenosine Diphosphate 198-201 Cd47 molecule Rattus norvegicus 237-240 2838021-5 1988 Photolabelling with 8-azido-ATP of the reconstituted Paracoccus enzyme also increases the Km for cytochrome c which is completely prevented if ATP but not if ADP is present during illumination as was found with reconstituted cytochrome c oxidase from bovine heart. Adenosine Diphosphate 158-161 LOC104968582 Bos taurus 97-109 2838021-6 1988 The data suggest a specific interaction of ATP and ADP with nuclear-coded subunits of bovine heart cytochrome c oxidase from the matrix side, because the effects are not found with the Paracoccus enzyme, which lacks these subunits. Adenosine Diphosphate 51-54 LOC104968582 Bos taurus 99-111 10030830-5 1999 In vitro ADP stimulation of platelets taken from seven healthy volunteers produced significant increases in the mean channel fluorescence intensities (MFI) for PAC-1 (148% increase) and CD62P (43% increase) but did not increase in that for CD63. Adenosine Diphosphate 9-12 dual specificity phosphatase 2 Homo sapiens 160-165 24221516-3 1988 Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM). Adenosine Diphosphate 110-113 keratin 1 Homo sapiens 241-244 24221516-3 1988 Formation of the pH gradient half-saturates at 0.3 mM MgATP, peaks at pH 7, and is competitively inhibited by ADP (k i<=0.1 mM), but not by Pi; it is hardly inhibited by orthovanadate, quickly dissipated by monensink 2=18 nM), nigericin (k 1/2=25 nM), and sluggishly by N-ethylmaleimide (k 1/2 35 muM). Adenosine Diphosphate 110-113 keratin 1 Homo sapiens 291-294 3346227-2 1988 Diphtheria toxin and Pseudomonas exotoxin A catalyze the transfer of an ADP-ribose residue from NAD to diphthamide, causing the inactivation of EF-2. Adenosine Diphosphate 72-75 elongation factor 2 Cricetulus griseus 144-148 3131319-6 1988 The extent of ADP-ribosylation-induced suppression of both activities was higher in the case of the modification of Arg1 than that of Arg9. Adenosine Diphosphate 14-17 arginase 1 Homo sapiens 116-120 2827787-2 1988 Synthetic peptides of sequence RGDS and HHLGGAKQAGDV, corresponding to regions of the fibrinogen alpha- and gamma-chains previously identified as platelet recognition sites, inhibited the binding of radiolabelled soluble fibrin oligomers to ADP-stimulated platelets with IC50 values of 10 and 40 microM, respectively. Adenosine Diphosphate 241-244 ral guanine nucleotide dissociation stimulator Homo sapiens 31-35 9891970-4 1998 In this study, we demonstrated that LAT is present in platelets and is tyrosine phosphorylated in response to ADP- and thrombin-stimulated aggregation. Adenosine Diphosphate 110-113 linker for activation of T cells Homo sapiens 36-39 2841683-4 1988 Nucleotides are suggested to regulate cytochrome c oxidase activity at 3 different sites: 1) Interaction of ATP with a cytosolic site (outside) increases the Km for cytochrome c in the enzyme from bovine heart and Paracoccus denitrificans; 2) binding of ADP at a matrix site decreases, and 3) binding of ATP at another matrix site increases the Km for cytochrome c of the mammalian enzyme. Adenosine Diphosphate 254-257 LOC104968582 Bos taurus 38-50 2841683-4 1988 Nucleotides are suggested to regulate cytochrome c oxidase activity at 3 different sites: 1) Interaction of ATP with a cytosolic site (outside) increases the Km for cytochrome c in the enzyme from bovine heart and Paracoccus denitrificans; 2) binding of ADP at a matrix site decreases, and 3) binding of ATP at another matrix site increases the Km for cytochrome c of the mammalian enzyme. Adenosine Diphosphate 254-257 LOC104968582 Bos taurus 165-177 2841683-4 1988 Nucleotides are suggested to regulate cytochrome c oxidase activity at 3 different sites: 1) Interaction of ATP with a cytosolic site (outside) increases the Km for cytochrome c in the enzyme from bovine heart and Paracoccus denitrificans; 2) binding of ADP at a matrix site decreases, and 3) binding of ATP at another matrix site increases the Km for cytochrome c of the mammalian enzyme. Adenosine Diphosphate 254-257 LOC104968582 Bos taurus 165-177 9665733-0 1998 Autophosphorylation and ADP regulate the Ca2+-dependent interaction of recoverin with rhodopsin kinase. Adenosine Diphosphate 24-27 recoverin Homo sapiens 71-80 9653141-3 1998 In this study, using specific antagonists for these two receptors, we demonstrated that concomitant intracellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 180-183 purinergic receptor P2Y12 Homo sapiens 138-143 9657959-11 1998 However, NTPase activity was specifically stimulated by the viral NS5 protein, which was manifested by a more than twofold increase in the rate of ATP hydrolysis and a 25% increase in the yield of ADP at the end of a 120-min reaction. Adenosine Diphosphate 197-200 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 66-69 9648840-6 1998 These results indicate that lack of, or reduction of, K(ATP) channel sensitivity to MgADP is a common molecular defect associated with the disease. Adenosine Diphosphate 84-89 ATPase phospholipid transporting 8A2 Homo sapiens 56-59 9609236-5 1998 Infusion of RGDS or Ro-43-8857 into ADP-stimulated PRP completely prevented adhesion as well as subsequent aggregation. Adenosine Diphosphate 36-39 ral guanine nucleotide dissociation stimulator Homo sapiens 12-16 9514746-1 1998 Selection for regain-of-function mutations in the yeast ADP/ATP carrier AAC2 has revealed an unexpected series of charge-pairs. Adenosine Diphosphate 56-59 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 72-76 9497339-4 1998 Rad51p binding to both 1-N6-ethenoadenosine and 3-N4-ethenocytidine ssDNA (epsilonDNA) and dsDNA requires the presence of Mg2+ and ATP; no binding occurs in the presence of ADP, AMP-PNP, or ATPgammaS. Adenosine Diphosphate 173-176 recombinase RAD51 Saccharomyces cerevisiae S288C 0-6 9497339-5 1998 Binding of Rad51p to dsDNA also requires ATP; ADP is ineffective, whereas ATPgammaS and AMP-PNP are considerably less able to promote binding and only at elevated concentrations of Rad51p. Adenosine Diphosphate 46-49 recombinase RAD51 Saccharomyces cerevisiae S288C 11-17 9511727-0 1998 Direct isolation and analysis of endogenous transjunctional ADP from Cx43 transfected C6 glioma cells. Adenosine Diphosphate 60-63 gap junction protein alpha 1 Homo sapiens 69-73 9511727-7 1998 This report demonstrates that ADP and/or ATP represents over 6% of the transjunctional material derived from glucose in Cx43-transfected C6 glioma cells. Adenosine Diphosphate 30-33 gap junction protein alpha 1 Homo sapiens 120-124 9623802-1 1998 Cytochrome c oxidase from bovine heart contains seven high-affinity binding sites for ATP or ADP and three additional only for ADP. Adenosine Diphosphate 93-96 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 0-20 2966106-5 1987 However, platelet CR3 does not merely bind C3bi, but the binding of the OKM1 antibody to platelet CR3 selectively blocks platelet functions of aggregation and serotonin release induced by arachadonic acid but not by other ligands (ristocetin, ADP, L-epinephrine, collagen and thrombin). Adenosine Diphosphate 243-246 teratocarcinoma-derived growth factor 1 pseudogene 3 Homo sapiens 98-101 2822043-0 1987 ADP increases the affinity for cytochrome c by interaction with the matrix side of bovine heart cytochrome c oxidase. Adenosine Diphosphate 0-3 LOC104968582 Bos taurus 31-43 2822043-0 1987 ADP increases the affinity for cytochrome c by interaction with the matrix side of bovine heart cytochrome c oxidase. Adenosine Diphosphate 0-3 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 96-116 9623802-1 1998 Cytochrome c oxidase from bovine heart contains seven high-affinity binding sites for ATP or ADP and three additional only for ADP. Adenosine Diphosphate 127-130 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 0-20 9623802-3 1998 Two further binding sites for ATP or ADP, located at the cytosolic and the matrix domain of subunit IV, increases the K(M) for cytochrome c and inhibit the respiratory activity at high ATP/ADP ratios, respectively. Adenosine Diphosphate 37-40 LOC104968582 Bos taurus 127-139 9623802-3 1998 Two further binding sites for ATP or ADP, located at the cytosolic and the matrix domain of subunit IV, increases the K(M) for cytochrome c and inhibit the respiratory activity at high ATP/ADP ratios, respectively. Adenosine Diphosphate 189-192 LOC104968582 Bos taurus 127-139 9839547-1 1998 The binding of insulin in physiological amounts to human blood platelets, which increases adenylate cyclase-linked prostacyclin receptor numbers on the cell surface, was found to be directly related to the ADP-ribosylation of the Gi alpha. Adenosine Diphosphate 206-209 prostaglandin I2 receptor Homo sapiens 115-136 10027001-1 1998 The FHIT gene, which encodes a 1-kb message and a 16.8-kDa protein that hydrolyses diadenosine triphosphate (ApppA) to ADP and AMP in vitro, covers a megabase genomic region at chromosome band 3p14.2. Adenosine Diphosphate 119-122 fragile histidine triad diadenosine triphosphatase Homo sapiens 4-8 2956659-4 1987 All these Ki values were much smaller than those of ADP which is also a competitive inhibitor for the ATPase activity of the recA protein. Adenosine Diphosphate 52-55 dynein axonemal heavy chain 8 Homo sapiens 102-108 3032310-4 1987 PGI2 and plasmin cause synergistic inhibition of thrombin- and ADP-induced aggregation of washed platelets. Adenosine Diphosphate 63-66 plasminogen Homo sapiens 9-16 3566278-4 1987 Passive binding and respiration-dependent accumulation of Mg2+ are strongly inhibited by K+ and other monovalent cations and the uptake reaction is further decreased by the presence of ATP or ADP. Adenosine Diphosphate 192-195 mucin 7, secreted Homo sapiens 58-61 2949742-3 1986 The presence of ATP, ADP or adenosine 5"-[beta, gamma-imido]triphosphate in the modification medium selectively protected against the inactivation of ATPase activity by the anhydride but did not protect against the inhibition of Ca2+ accumulation. Adenosine Diphosphate 21-24 dynein axonemal heavy chain 8 Homo sapiens 150-156 9223456-5 1997 The potency order for the induction of fMLP-stimulated beta-glucuronidase release by adenine nucleotides and adenosine was ATPgammaS > or = ATP > ADP > AMP = Adenosine approximately 0. Adenosine Diphosphate 152-155 glucuronidase beta Homo sapiens 55-73 3778531-0 1986 [Inhibition of ADP-ribosylation by nerve growth factor in the pheochromocytoma PC-12 cell line]. Adenosine Diphosphate 15-18 nerve growth factor Rattus norvegicus 35-54 9237625-2 1997 The reaction product ADP inhibits this ATPase activity. Adenosine Diphosphate 21-24 dynein axonemal heavy chain 8 Homo sapiens 39-45 3778531-3 1986 NGF inhibited ADP-ribosylation of several proteins, including a protein with molecular weight of 40,000, probably of membrane origin. Adenosine Diphosphate 14-17 nerve growth factor Rattus norvegicus 0-3 9126325-5 1997 The potency order for the induction of fMLP-stimulated beta-glucuronidase release by adenine nucleotides and adenosine was ATP gamma S > 3 ATP > ADP > AMP = Adenosine approximately 0. Adenosine Diphosphate 151-154 glucuronidase beta Homo sapiens 55-73 9131990-2 1997 Here we describe a study of the formation of complexes between the molecular chaperone DnaK, its nucleotide exchange factor GrpE, and the fluorescent ADP analog N8-[4-[(N"-methylanthraniloyl)amino]butyl]-8-aminoadenosine 5"-diphosphate (MABA-ADP) by equilibrium and stopped flow kinetic experiments. Adenosine Diphosphate 150-153 GrpE like 1, mitochondrial Homo sapiens 124-128 3084483-9 1986 Thus, GTP-binding proteins serving as the substrate of IAP-catalyzed ADP-ribosylation are capable of interaction functionally with muscarinic receptors in phospholipid vesicles. Adenosine Diphosphate 69-72 Cd47 molecule Rattus norvegicus 55-58 2869109-7 1986 The phenomenon probably arises from the production by glutamine synthetase of ADP, a known product inhibitor of ATP citrate lyase. Adenosine Diphosphate 78-81 ATP citrate lyase Rattus norvegicus 112-129 2936732-0 1986 Kinetic effects of calcium and ADP on the phosphorylated intermediate of sarcoplasmic reticulum ATPase. Adenosine Diphosphate 31-34 dynein axonemal heavy chain 8 Homo sapiens 96-102 3003346-3 1986 A competitive inhibitor of 5"-nucleotidase, alpha,beta-methyleneadenosine diphosphate (120 microM), inhibited the production of adenosine during hypoxia (perfusate, 0.26 +/- 0.05 microM and renal cortex, 3.1 nmol/g) but did not prevent the decline in cortical tissue ATP and ADP. Adenosine Diphosphate 275-278 5' nucleotidase, ecto Rattus norvegicus 27-42 3023860-1 1986 The ADP/ATP translocator, a transmembrane protein of the mitochondrial inner membrane, is coded in Saccharomyces cerevisiae by the nuclear gene PET9. Adenosine Diphosphate 4-7 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 144-148 2417360-0 1985 Beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) release by adenosine diphosphate (ADP) contact with native whole blood. Adenosine Diphosphate 70-91 pro-platelet basic protein Homo sapiens 0-20 2417360-0 1985 Beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) release by adenosine diphosphate (ADP) contact with native whole blood. Adenosine Diphosphate 70-91 platelet factor 4 Homo sapiens 54-57 2417360-0 1985 Beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) release by adenosine diphosphate (ADP) contact with native whole blood. Adenosine Diphosphate 93-96 pro-platelet basic protein Homo sapiens 0-20 2417360-0 1985 Beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) release by adenosine diphosphate (ADP) contact with native whole blood. Adenosine Diphosphate 93-96 platelet factor 4 Homo sapiens 54-57 3922980-8 1985 The half-maximal concentration of IAP to inhibit GTPase activity was comparable to that of the toxin to inhibit the cellular arachidonate-releasing response which was well correlated with ADP-ribosylation of a membrane Mr = 41,000 protein (Okajima, F., and Ui, M. (1984) J. Biol. Adenosine Diphosphate 188-191 islet amyloid polypeptide Homo sapiens 34-37 2859288-0 1985 Mitochondrial F1-ATPase will bind and cleave ATP but only slowly release ADP after N,N"-dicyclohexylcarbodiimide or 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole derivatization. Adenosine Diphosphate 73-76 dynein axonemal heavy chain 8 Homo sapiens 17-23 2985044-2 1985 ADP and ATP and their analogues were evaluated as inhibitors of 5"-nucleotidase purified from heart plasma membrane. Adenosine Diphosphate 0-3 5' nucleotidase, ecto Rattus norvegicus 64-79 2985044-9 1985 The thiophosphate analogues of ADP all inhibit 5"-nucleotidase, although not as powerfully as ADP, the most effective of these analogues being adenosine 5"-O-(1-thiodiphosphate) diastereoisomer B (ADP[alpha S](B)]. Adenosine Diphosphate 31-34 5' nucleotidase, ecto Rattus norvegicus 47-62 2988168-3 1985 In the domain of high ATP concentrations, where low affinity site is saturated, ADP is a competitive inhibition of ATPase reaction with Ki of 300 microM. Adenosine Diphosphate 80-83 dynein axonemal heavy chain 8 Homo sapiens 115-121 3970545-2 1985 MNNG treatment of cells caused a rapid and transient increase in ADP ribosylation of histone H1 and HMG 1 and 2, whereas (ADP-ribose)n on HMG 14 and 17 was not affected. Adenosine Diphosphate 65-68 H1.2 linker histone, cluster member Mus musculus 85-111 3970545-5 1985 The preferential increase in ADP ribosylation of HMG 1 and 2 and histone H1 may be necessary for cell recovery from DNA damage. Adenosine Diphosphate 29-32 high mobility group box 1 Mus musculus 49-54 3967086-6 1985 At a concentration of apyrase or CP/CPK, which inhibited adenosine 5-diphosphate-induced aggregation. Adenosine Diphosphate 57-80 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 36-39 2981281-0 1985 Decrease of clonidine binding affinity to alpha 2-adrenoceptor by ADP-ribosylation of 41,000-dalton proteins in rat cerebral cortical membranes by islet-activating protein. Adenosine Diphosphate 66-69 Cd47 molecule Rattus norvegicus 147-171 3917919-5 1985 A direct kinetic correlation between ADP-ribose incorporation, polynucleosome relaxation amd histone H1 hyper-ADP-ribosylation was established. Adenosine Diphosphate 37-40 H1.0 linker histone Rattus norvegicus 93-103 6335031-3 1984 Steady-state kinetic analysis of ATP citrate lyase was complicated by the presence of ADP, a product of the reaction, in solutions of ATP. Adenosine Diphosphate 86-89 ATP citrate lyase Rattus norvegicus 33-50 6090133-6 1984 Polynucleotide phosphorylase (PNPase) was found both in thylakoid and CF1 preparations and catalyzed the formation of [beta-32P]ADP via its Pi----ADP exchange activity. Adenosine Diphosphate 128-131 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 0-28 6090133-6 1984 Polynucleotide phosphorylase (PNPase) was found both in thylakoid and CF1 preparations and catalyzed the formation of [beta-32P]ADP via its Pi----ADP exchange activity. Adenosine Diphosphate 128-131 polyribonucleotide nucleotidyltransferase 1 Homo sapiens 30-36 6237610-3 1984 The inhibitions by these analogs were much stronger than that by ADP, which is also a competitive inhibitor for the ATPase activity of the recA protein. Adenosine Diphosphate 65-68 dynein axonemal heavy chain 8 Homo sapiens 116-122 6323430-3 1984 This appears to result from IAP-catalyzed ADP-ribosylation of a 41,000-Da membrane-bound protein. Adenosine Diphosphate 42-45 islet amyloid polypeptide Homo sapiens 28-31 6319392-6 1984 The enzyme catalyzed ADP/ATP and Fru-6-P/Fru-2,6-P2 exchanges at rates comparable to net reaction rates. Adenosine Diphosphate 21-24 zinc finger and BTB domain containing 22 Homo sapiens 41-44 6225641-12 1983 Activation of a Mg-specific ATPase in CF1 by octyl glucoside decreases the affinity for ADP and inorganic phosphate by about threefold but increases the affinity for ATP. Adenosine Diphosphate 88-91 dynein axonemal heavy chain 8 Homo sapiens 28-34 6225641-13 1983 ATPase activation of CF1 also increases the Ki for ADP inhibition of ATP hydrolysis. Adenosine Diphosphate 51-54 dynein axonemal heavy chain 8 Homo sapiens 0-6 6416107-2 1983 Both procedures are based on the measurement of ADP formed during enzymatic phosphorylation of the analogs either by hexokinase or by fructokinase. Adenosine Diphosphate 48-51 ketohexokinase Homo sapiens 134-146 6139371-11 1983 A conformational difference between ECa1-P X ADP and ECa1-P was suggested from saturation transfer ESR measurement of spin-labeled ATPase by using ADP beta S as an ADP analog to cause accumulation of ECa1-P X ADP beta S complex. Adenosine Diphosphate 45-48 ECA1 Homo sapiens 36-40 6873252-4 1983 The application of precursors of ATP biosynthesis, labeled with suitable radionuclides (32Pi and [14C]ADP), makes it possible to prove that ATP is formed in the absence of inhibitors. Adenosine Diphosphate 102-105 ATPase phospholipid transporting 8A2 Homo sapiens 33-36 6873252-4 1983 The application of precursors of ATP biosynthesis, labeled with suitable radionuclides (32Pi and [14C]ADP), makes it possible to prove that ATP is formed in the absence of inhibitors. Adenosine Diphosphate 102-105 ATPase phospholipid transporting 8A2 Homo sapiens 140-143 6833826-6 1983 When platelets in TAS were sheared in the presence of CP/CPK, an enzyme system capable of removing extracellular ADP, PAG was only partially (approximately 40%) inhibited. Adenosine Diphosphate 113-116 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 57-60 6844350-2 1983 We found that PAAF interferes with hepatic mitochondrial respiration resulting in severe disturbances in respiratory control (RCR) and ADP/O ratios. Adenosine Diphosphate 135-138 proteasomal ATPase associated factor 1 Homo sapiens 14-18 6824640-8 1983 Thus far Mg2+, Mn2+, Co2+, Ni2+, and Ca2+ but not Zn2+ all function to promote trapping of the 1:1 divalent metal-ADP complex and to enhance the rate of ATPase inactivation. Adenosine Diphosphate 114-117 dynein axonemal heavy chain 8 Homo sapiens 153-159 6227139-3 1983 Platelets held at room temperature maintained their ability to aggregate and release BTG in response to ADP after 3 days storage. Adenosine Diphosphate 104-107 pro-platelet basic protein Homo sapiens 85-88 6227139-5 1983 After 4-6 days, platelets stored at room temperature showed a smaller spontaneous loss of BTG than those stored at 4 degrees C. Spontaneous release of BTG from platelets in whole blood stored at 4 degrees C was significantly lower than from platelets stored as concentrates, although platelets prepared from whole blood stored for 1 day showed neither release nor aggregation in response to ADP stimulation. Adenosine Diphosphate 391-394 pro-platelet basic protein Homo sapiens 151-154 6227139-6 1983 We suggest that ADP-stimulated BTG release may be a sensitive tests of platelet function during storage. Adenosine Diphosphate 16-19 pro-platelet basic protein Homo sapiens 31-34 6219104-0 1982 Modulation of the chloroplast ATPase by tight ADP binding. Adenosine Diphosphate 46-49 dynein axonemal heavy chain 8 Homo sapiens 30-36 6219104-2 1982 Inactivation of the membrane-bound ATPase by tight ADP binding was studied under nonenergized conditions. Adenosine Diphosphate 51-54 dynein axonemal heavy chain 8 Homo sapiens 35-41 6124538-3 1982 Whereas at 0 degrees C, ATP gamma S showed only a limited reactivity toward the ATPase in that a thiophosphorylated intermediate was formed and ADP was released, but hydrolysis of the intermediate to complete the catalytic cycle did not occur. Adenosine Diphosphate 144-147 dynein axonemal heavy chain 8 Homo sapiens 80-86 7037068-6 1982 The ADP scavengers, creatine phosphate and creatine phosphokinase (CP/CPK), inhibited the second wave of aggregation but not secretion. Adenosine Diphosphate 4-7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 70-73 6174155-3 1982 Adenine incorporation into the nucleotides proceeds via adenine-phosphoribosyl transferase, which is rate-limiting to AMP formation and subsequently the formation of ADP and ATP. Adenosine Diphosphate 166-169 adenine phosphoribosyl transferase Mus musculus 56-90 6211399-4 1982 Both 5-hydroxy-tryptamine and beta-thromboglobulin release were greater with patients" platelets than with those of controls in response to adrenaline, ADP and U44069. Adenosine Diphosphate 152-155 pro-platelet basic protein Homo sapiens 30-50 6257855-3 1981 The isolated TSH A and B subunits were tested for their ADP-ribose acceptor activity. Adenosine Diphosphate 56-59 glycoprotein hormones, alpha polypeptide Homo sapiens 13-24 6257855-4 1981 The TSH A subunit showed fourfold greater ADP-ribose acceptor activity than the TSH B subunit. Adenosine Diphosphate 42-45 glycoprotein hormones, alpha polypeptide Homo sapiens 4-9 6786284-3 1980 On assay of the reduction of ADP-Fe3+ chelate by the reduction of cytochrome c in the presence of superoxide dismutase and antimycin A or by the oxidation of reduced coenzymes, the reactions were not affected by rotenone but were inhibited by thiol-group inhibitors. Adenosine Diphosphate 29-32 LOC104968582 Bos taurus 66-78 6156020-7 1980 The fate of ATP and ADP in the binding reaction of BP-6-CH2OH was examined by thin layer chromatography. Adenosine Diphosphate 20-23 BP6 Homo sapiens 51-61 7392371-4 1980 The creatine phosphate thus formed after diffusion in the cytoplasm is used in creatine phosphokinase reactions in the myofibrils and on the cell membranes for the continuous resynthesis of ATP from ADP, the product of ATP-ase reactions. Adenosine Diphosphate 199-202 dynein axonemal heavy chain 8 Homo sapiens 219-226 7404268-3 1980 In one class, the entire elongation factor-2 (EF-2) activity becomes resistant to DT-catalyzed ADP-ribosylation (DiprIIa class); these mutants behave recessively upon hybridization with sensitive cells. Adenosine Diphosphate 95-98 elongation factor 2 Cricetulus griseus 25-44 7404268-3 1980 In one class, the entire elongation factor-2 (EF-2) activity becomes resistant to DT-catalyzed ADP-ribosylation (DiprIIa class); these mutants behave recessively upon hybridization with sensitive cells. Adenosine Diphosphate 95-98 elongation factor 2 Cricetulus griseus 46-50 7404268-4 1980 The second kind of protein synthesis mutants contain nearly normal levels of the ADP-ribosylatable EF-2 activity (DiprIIb class). Adenosine Diphosphate 81-84 elongation factor 2 Cricetulus griseus 99-103 6444523-0 1980 Binding of ADP to beef-heart mitochondrial ATPase (F1). Adenosine Diphosphate 11-14 ATP synthase F1 subunit epsilon Homo sapiens 29-49 6444523-2 1980 ADP binding to beef-heart mitochondrial ATPase (F1), in the absence of Mg2+, has been determined by separating the free ligand by ultrafiltration and determining it in the filtrate by a specially modified isotachophoretic procedure. Adenosine Diphosphate 0-3 ATP synthase F1 subunit epsilon Homo sapiens 26-46 6928655-1 1980 We have identified two types of mutants of Chinese hamster ovary cells in which the unique ADP-ribose attachment site in elongation factor 2 (EF-2) is altered, thereby rendering them resistant to diphtheria and Pseudomonas toxins (TOXR). Adenosine Diphosphate 91-94 elongation factor 2 Cricetulus griseus 121-140 6928655-1 1980 We have identified two types of mutants of Chinese hamster ovary cells in which the unique ADP-ribose attachment site in elongation factor 2 (EF-2) is altered, thereby rendering them resistant to diphtheria and Pseudomonas toxins (TOXR). Adenosine Diphosphate 91-94 elongation factor 2 Cricetulus griseus 142-146 6928655-4 1980 We postulate that this modification system is involved in the conversion of a single histidine residue in EF-2 to the specific target of toxin-catalyzed ADP-ribosylation, the novel amino acid X. Adenosine Diphosphate 153-156 elongation factor 2 Cricetulus griseus 106-110 6250824-4 1980 About 30% of the bound NAD+ could be reduced with rabbit muscle lactae dehydrogenase, yeast alcohol dehydrogenase and Bacillus subtilis alanine dehydrogenase; 84% of the bound ADP was phosphorylated with rabbit muscle creatine kinase. Adenosine Diphosphate 176-179 creatine kinase M-type Oryctolagus cuniculus 211-233 7350241-7 1980 These results are inconsistent with the idea that CP/CPK blocks second-wave aggregation by removing secreted ADP, but they are consistent with a decreased potentiation of the platelets due to a lower level of extracellular ADP prior to stimulation. Adenosine Diphosphate 109-112 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 50-56 6264330-5 1980 (1)5"-Nucleotidase inhibitors blocked the accumulations of cyclic AMP elicited by AMP, ADP, and ATP, but did not affect the response to adenosine. Adenosine Diphosphate 87-90 5'-nucleotidase ecto Homo sapiens 3-18 41710-5 1979 ADP and ATP with or without cations provide efficient protection only against the loss of ATPase activities, suggesting that the second inhibitory process is occurring at or close to the active site. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 90-96 284336-6 1979 A numerical example is included that illustrates respiratory control in a qualitative way: although the respiratory chain flux by itself does not depend on ADP concentration, the steady-state flux of the coupled systems (respiratory chain and reverse ATPase) does depend on ADP concentration through the interior ligand (H+) concentration. Adenosine Diphosphate 274-277 dynein axonemal heavy chain 8 Homo sapiens 251-257 78721-5 1978 PF4 and betaTG were released by ADP and collagen with time course and concentration dependence similar to that of [14C]serotonin release. Adenosine Diphosphate 32-35 platelet factor 4 Homo sapiens 0-3 202953-2 1977 The symmetric molecule, Ap(5)A, is a potent inhibitor of the adenylate kinase reaction, 2 ADP right arrow over left arrow ATP + AMP. Adenosine Diphosphate 90-93 ATPase phospholipid transporting 8A2 Homo sapiens 122-125 889576-1 1977 Inhibition studies of glucokinase were carried out with the products of the reaction, glucose 6-phosphate and MgADP-, as well as with ADP3-, Mg2+ and ATP4-. Adenosine Diphosphate 110-115 glucokinase Rattus norvegicus 22-33 21484-3 1977 The activity of NADP-dependent glutathione reductase was increased under effect of ADP; at the same time, the activity of NAD-dependent glutathione reductase did not depend on the diphosphate effect. Adenosine Diphosphate 17-20 glutathione-disulfide reductase Homo sapiens 31-52 21484-3 1977 The activity of NADP-dependent glutathione reductase was increased under effect of ADP; at the same time, the activity of NAD-dependent glutathione reductase did not depend on the diphosphate effect. Adenosine Diphosphate 17-20 glutathione-disulfide reductase Homo sapiens 136-157 408012-2 1977 EF-2 prepared from the cytoplasmic variants was resistant to ADP-ribosylation by either toxin. Adenosine Diphosphate 61-64 elongation factor 2 Cricetulus griseus 0-4 16592374-3 1976 Other results give evidence that upon energization, the tightly bound ADP that is detectable in isolated thylakoid membranes or coupling factor ATPase is rapidly released to the medium from a catalytic site. Adenosine Diphosphate 70-73 dynein axonemal heavy chain 8 Homo sapiens 144-150 180020-10 1976 Addition of ADP to the phosphorylated intermediate of DPL-enzyme induces a fast reversal of the phosphorylation reaction. Adenosine Diphosphate 12-15 prion like protein doppel Homo sapiens 54-57 132526-26 1976 The garfish Na-K-ATPase is sensitive to the ATP/ADP ratio of the incubating medium, but is relatively insensitive to orthophosphate, Pi. Adenosine Diphosphate 48-51 dynein axonemal heavy chain 8 Homo sapiens 17-23 953055-3 1976 ADP binding could be analyzed and gave a dissociation constant of 10-20 muM at neutral pH, and a stoichiometry of 0.35 - 0.45 per mole ATPase. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 135-141 239948-2 1975 5-Oxo-L-prolinase, an enzyme that catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate; L-2-pyrrolidone-5-carboxylate) to L-glutamate coupled with the cleavage of ATP to ADP and Pi, has been purified about 1600-fold from rat kidney. Adenosine Diphosphate 178-181 5-oxoprolinase (ATP-hydrolysing) Rattus norvegicus 0-17 125750-10 1975 The steady-state ATPase rate of subfragment-1 prepared by tryptic digestion was inhibited competitively by ADP in the presence of MgCl2. Adenosine Diphosphate 107-110 dynein axonemal heavy chain 8 Homo sapiens 17-23 125750-11 1975 The extent of the initial burst of ATPase [EC 3.6.1.3] decreased from 0.46 +/- 0.06 to 0.30 +/- 0.09 mole of Pi per 10(5) g of subfragment-1 on adding ADP to a level of 0.6 mM. Adenosine Diphosphate 151-154 dynein axonemal heavy chain 8 Homo sapiens 35-41 4369034-13 1974 The partial purification of rat liver glucokinase on an ADP derivative is shown. Adenosine Diphosphate 56-59 glucokinase Rattus norvegicus 38-49 5289242-1 1971 A new enzyme, 5-oxoprolinase, was found in rat kidney and in several other tissues; it catalyzes the conversion of 5-oxo-L-proline (L-5-oxo-pyrrolidine-2-carboxylic acid, L-2-pyrrolidone-5-carboxylic acid, L-pyroglutamic acid) to L-glutamic acid, with concomitant stoichiometric cleavage of ATP to ADP and orthophosphate. Adenosine Diphosphate 298-301 5-oxoprolinase (ATP-hydrolysing) Rattus norvegicus 14-28 11947284-0 1969 The requirements of adenosine diphosphate for light-triggered ATPase and ATP-Pi exchange reactions in chloroplasts. Adenosine Diphosphate 20-41 dynein axonemal heavy chain 8 Homo sapiens 62-68 5649642-5 1968 Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4. Adenosine Diphosphate 125-128 glucuronidase beta Homo sapiens 18-36 5649642-5 1968 Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4. Adenosine Diphosphate 125-128 glucuronidase beta Homo sapiens 216-234 5892949-0 1965 Changes in the radioactivity of P-32-labelled acid-soluble organophosphates in blood platelets during collagen-and adenosine diphosphate-induced platelet aggregation. Adenosine Diphosphate 115-136 inhibitor of growth family member 2 Homo sapiens 32-36 32787598-6 2021 Moreover, the higher lipoprotein(a) group also exhibited significantly higher adenosine diphosphate (ADP) induced platelet aggregation (MAADP) by thrombelastography platelet mapping assay than lower lipoprotein(a) group. Adenosine Diphosphate 101-104 lipoprotein(a) Homo sapiens 21-35 33909515-6 2021 EXPERT OPINION: : Considerable advances have been reported in the design of nucleotide/nucleoside-based CD73 inhibitors, after the X-ray crystal structure of the enzyme in complex with the non-hydrolyzable ADP analog, adenosine (alpha,beta)-methylene diphosphate (AMPCP), was reported. Adenosine Diphosphate 206-209 5'-nucleotidase ecto Homo sapiens 104-108 33161021-2 2021 ATP is released from cells under physiologic and pathophysiologic condition; extracellular ATP is rapidly degraded to adenosine 5"-diphosphate (ADP) and adenosine by ecto-enzymes (mainly, CD39 and CD73). Adenosine Diphosphate 144-147 5'-nucleotidase ecto Homo sapiens 197-201 33888587-4 2021 Using free-energy landscapes computed through molecular dynamics simulations, we determined the stable conformational state of the ATPase active site in ATP- and ADP-bound states. Adenosine Diphosphate 162-165 dynein axonemal heavy chain 8 Homo sapiens 131-137 33888587-8 2021 Specifically, we showed that the crystal structure of the ADP-bound P74-26 packaging ATPase is consistent with the structural coupling predicted from simulations, and we further showed that disrupting the predicted signaling pathway indeed decouples ATPase activity from DNA translocation activity in the phi29 DNA packaging motor. Adenosine Diphosphate 58-61 dynein axonemal heavy chain 8 Homo sapiens 85-91 33888587-8 2021 Specifically, we showed that the crystal structure of the ADP-bound P74-26 packaging ATPase is consistent with the structural coupling predicted from simulations, and we further showed that disrupting the predicted signaling pathway indeed decouples ATPase activity from DNA translocation activity in the phi29 DNA packaging motor. Adenosine Diphosphate 58-61 dynein axonemal heavy chain 8 Homo sapiens 250-256 33859040-9 2021 Collectively, our findings demonstrate that depolarization-dependent regulation of PLC-beta-IP3R signaling is required for modulation of the ATP/ADP ratio in healthy glutamatergic neurons, whereas hyperactivation of this axis in chronically depolarized glutamatergic neurons shortens animal lifespan by promoting endolysosomal Ca2+ overload. Adenosine Diphosphate 145-148 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 92-96 33576028-5 2021 The relationship between [ADP] and muscle power output was augmented at workloads above the pH threshold (pHT ; proxy for LT), whereas increases in ATPOX were attenuated. Adenosine Diphosphate 26-29 phenylalanine hydroxylase Homo sapiens 92-94 33790902-4 2021 Adenylate kinase 4 (Ak4), an enzyme that transfers phosphate group among ATP/GTP, AMP, and ADP, is a key modulator of ATP and maintains the homeostasis of cellular nucleotides which is essential for cell functions. Adenosine Diphosphate 91-94 adenylate kinase 4 Homo sapiens 0-18 33790902-4 2021 Adenylate kinase 4 (Ak4), an enzyme that transfers phosphate group among ATP/GTP, AMP, and ADP, is a key modulator of ATP and maintains the homeostasis of cellular nucleotides which is essential for cell functions. Adenosine Diphosphate 91-94 adenylate kinase 4 Homo sapiens 20-23 33860201-3 2021 We performed a high-throughput screen (HTS) of 158 410 compounds for IP6K1 inhibitors using a previously developed ADP-Glo Max assay. Adenosine Diphosphate 115-118 inositol hexakisphosphate kinase 1 Homo sapiens 69-74 33627709-2 2021 Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cytosolic kinase region captures ADP. Adenosine Diphosphate 134-137 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 45-49 33627709-5 2021 ER-stress responsiveness of deltaIdeltaIIIdeltaV/Y225H Ire1 was largely compromised by a further mutation on the kinase region, D797N/K799N, which allows Ire1 to be activated without capturing ADP. Adenosine Diphosphate 193-196 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 55-59 33627709-7 2021 We propose that potent ER stress harms cells" "vividness", increasing the cytosolic ADP/ATP ratio, and eventually strongly activates Ire1. Adenosine Diphosphate 84-87 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 133-137 33524397-5 2021 Using multi-angle light scattering (MALS) we show that ADP is able to promote tetramer formation of both CtBP1 and CtBP2, whereas AMP promotes tetramer assembly of CtBP1, but not CtBP2. Adenosine Diphosphate 55-58 C-terminal binding protein 1 Homo sapiens 105-110 33552071-9 2020 Finally, we show that SIRPalpha suppression is mediated via the phosphatase, Shp1, which in turn suppresses SYK-dependent activation of ADP. Adenosine Diphosphate 136-139 nuclear receptor subfamily 0 group B member 2 Homo sapiens 77-81 32356316-3 2020 Mechanistically, MA suppressed U46619- or ADP-induced phosphorylation of myristoylated alanine-rich C kinase substrate, and the expression of P-selectin, and activated PAC-1 in platelets. Adenosine Diphosphate 42-45 myristoylated alanine rich protein kinase C substrate Homo sapiens 73-118 32356316-3 2020 Mechanistically, MA suppressed U46619- or ADP-induced phosphorylation of myristoylated alanine-rich C kinase substrate, and the expression of P-selectin, and activated PAC-1 in platelets. Adenosine Diphosphate 42-45 dual specificity phosphatase 2 Homo sapiens 168-173 32941855-6 2020 ATP and ADP enhanced phosphorylation of ERK1/2 by suppressing MKP-1 and MKP-3 expression after gamma-irradiation. Adenosine Diphosphate 8-11 dual specificity phosphatase 6 Homo sapiens 72-77 33139725-7 2020 Microtubule sliding of dyskinetic sperm from Cfap45-/- mice is rescued with the addition of either AMP or ADP with ATP, compared to ATP alone. Adenosine Diphosphate 106-109 cilia and flagella associated protein 45 Mus musculus 45-51 32889667-5 2020 The primary objective was to evaluate the association between Lp(a) and adenosine diphosphate (ADP)-induced platelet reactivity using the VerifyNow P2Y12 assay. Adenosine Diphosphate 95-98 lipoprotein(a) Homo sapiens 62-67 32867554-7 2020 ATP-mediated P2X7R activation and ADP-mediated activation of P2Y1R and P2Y12R play a role in pulmonary vascular tone, vascular remodeling, and inflammation in PAH. Adenosine Diphosphate 34-37 purinergic receptor P2Y12 Homo sapiens 71-77 9131990-3 1997 The catalytic cycle of the GrpE-stimulated nucleotide exchange involves a ternary DnaK x GrpE x ADP complex as well as the binary DnaK x GrpE and DnaK x ADP complexes. Adenosine Diphosphate 96-99 GrpE like 1, mitochondrial Homo sapiens 27-31 9131990-3 1997 The catalytic cycle of the GrpE-stimulated nucleotide exchange involves a ternary DnaK x GrpE x ADP complex as well as the binary DnaK x GrpE and DnaK x ADP complexes. Adenosine Diphosphate 153-156 GrpE like 1, mitochondrial Homo sapiens 27-31 9131990-4 1997 The equilibrium data of the interaction of GrpE with DnaK x ADP and the nucleotide-free DnaK can be described by a simple equilibrium system where GrpE reduces the affinity of ADP for DnaK 200-fold. Adenosine Diphosphate 60-63 GrpE like 1, mitochondrial Homo sapiens 43-47 9131990-4 1997 The equilibrium data of the interaction of GrpE with DnaK x ADP and the nucleotide-free DnaK can be described by a simple equilibrium system where GrpE reduces the affinity of ADP for DnaK 200-fold. Adenosine Diphosphate 60-63 GrpE like 1, mitochondrial Homo sapiens 147-151 9131990-4 1997 The equilibrium data of the interaction of GrpE with DnaK x ADP and the nucleotide-free DnaK can be described by a simple equilibrium system where GrpE reduces the affinity of ADP for DnaK 200-fold. Adenosine Diphosphate 176-179 GrpE like 1, mitochondrial Homo sapiens 43-47 9131990-4 1997 The equilibrium data of the interaction of GrpE with DnaK x ADP and the nucleotide-free DnaK can be described by a simple equilibrium system where GrpE reduces the affinity of ADP for DnaK 200-fold. Adenosine Diphosphate 176-179 GrpE like 1, mitochondrial Homo sapiens 147-151 9131990-5 1997 However, transient kinetic studies revealed that the functional cycle of GrpE in addition includes at least two distinct ternary DnaK x GrpE x ADP complexes. Adenosine Diphosphate 143-146 GrpE like 1, mitochondrial Homo sapiens 73-77 9131990-5 1997 However, transient kinetic studies revealed that the functional cycle of GrpE in addition includes at least two distinct ternary DnaK x GrpE x ADP complexes. Adenosine Diphosphate 143-146 GrpE like 1, mitochondrial Homo sapiens 136-140 9131990-6 1997 Our data indicate that the initial weak binding of GrpE to DnaK x ADP is followed by an isomerization of the ternary complex which leads to weakening of nucleotide binding and finally to its rapid dissociation. Adenosine Diphosphate 66-69 GrpE like 1, mitochondrial Homo sapiens 51-55 9125201-0 1997 Effects of ADP, DTT, and Mg2+ on the ion-conductive property of chloroplast H+-ATPase(CF0-CF1) reconstituted into bilayer membrane. Adenosine Diphosphate 11-14 plasma membrane ATPase 4 Glycine max 76-85 9020154-11 1997 ADP-ribosylarginine hydrolase, which preferentially hydrolyzes the alpha-anomer of ADP-ribosylarginine, released [U-14C]arginine from ADP-ribosyl[U-14C]arginine synthesized by mRT6.1, consistent with the conclusion that mRt6.1 catalyzes a stereospecific Sn2-like reaction. Adenosine Diphosphate 0-3 ADP-ribosyltransferase 2a Mus musculus 176-180 9020154-11 1997 ADP-ribosylarginine hydrolase, which preferentially hydrolyzes the alpha-anomer of ADP-ribosylarginine, released [U-14C]arginine from ADP-ribosyl[U-14C]arginine synthesized by mRT6.1, consistent with the conclusion that mRt6.1 catalyzes a stereospecific Sn2-like reaction. Adenosine Diphosphate 0-3 ADP-ribosyltransferase 2a Mus musculus 220-226 9059849-10 1997 In a model of fatal pulmonary thromboembolism induced by intravenous injection of ADP (300 micrograms/g), YC-1 was effective in reducing mortality when administered intraperitoneally at doses of 10-30 micrograms/g. Adenosine Diphosphate 82-85 RNA binding motif, single stranded interacting protein 1 Mus musculus 106-110 9059849-11 1997 The antithrombotic effect of YC-1 was correlated with the inhibition of ADP-induced platelet aggregation ex vivo. Adenosine Diphosphate 72-75 RNA binding motif, single stranded interacting protein 1 Mus musculus 29-33 8995355-3 1997 The microtubule-activated ATPase is 60 s(-1) at 20 degrees C; Km(Mt) is 5 microM; dissociation constants in the presence of ATP and ADP are 9 microM and 16 microM, respectively. Adenosine Diphosphate 132-135 dynein axonemal heavy chain 8 Homo sapiens 26-32 9193651-3 1997 While mouse Rt6 proteins were found to be strong arginine-specific transferases, but comparatively weak NADases, the opposite held true for rat RT6, for which transferase activity could only be detected in the form of arginine-specific auto-ADP-ribosylation, displayed by RT6.2 but not by RT6.1. Adenosine Diphosphate 241-244 ADP-ribosyltransferase 2a Mus musculus 12-15 8972712-0 1996 Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets. Adenosine Diphosphate 11-14 protein tyrosine kinase 2 Homo sapiens 67-88 8861908-3 1996 Using cryo-electron microscopy, we have obtained three-dimensional reconstructions to 30 A resolution for GroEL and GroEL-GroES complexes in the presence of ADP, ATP, and the nonhydrolyzable ATP analog, AMP-PNP. Adenosine Diphosphate 157-160 heat shock protein family E (Hsp10) member 1 Homo sapiens 122-127 8843758-2 1996 However, glucokinase also has extraordinarily high control strength on insulin secretion, which is linked to the phosphate potential, [ATP]/([ADP][Pi]) (F.M. Adenosine Diphosphate 142-145 glucokinase Rattus norvegicus 9-20 8752121-7 1996 Serotonin-induced, magnesium-dependent reduction in PTX-mediated ADP-ribosylation of G alpha i/G alpha o in cortical membranes from bipolar brains was greater than that observed in controls, providing further evidence for enhanced receptor-G protein coupling in bipolar brain membranes. Adenosine Diphosphate 65-68 G protein subunit alpha o1 Homo sapiens 95-104 8701947-4 1996 During the second phase of ADP-induced aggregation, 69.0 +/- 8.3% of beta TG and 54.1 +/- 4.6% of 14C-serotonin were released (mean +/- SEM, n = 13); aspirin treatment reduced these values to 6.0 +/- 1.2 and 1.0 +/- 0.3%, respectively. Adenosine Diphosphate 27-30 pro-platelet basic protein Homo sapiens 69-76 8701947-5 1996 In contrast, incubation of platelets with ADP without stirring caused only 6.7 +/- 1.7% release of beta TG and 2.1 +/- 0.4% release of 14C-serotonin; these low values were not appreciably affected by aspirin. Adenosine Diphosphate 42-45 pro-platelet basic protein Homo sapiens 99-114 8701947-6 1996 During ADP-induced primary aggregation in PRP anticoagulated with FPRCH2CI (PPACK), only 4.7 +/- 0.9% release of beta TG and no detectable release of 14C-serotonin occurred; aspirin had no effect. Adenosine Diphosphate 7-10 pro-platelet basic protein Homo sapiens 113-120 8764609-0 1996 A low-Km 5"-nucleotidase from rat brain cytosolic fraction: purification, kinetic properties, and description of regulation by a novel factor that increases sensitivity to inhibition by ATP and ADP. Adenosine Diphosphate 194-197 5' nucleotidase, ecto Rattus norvegicus 9-24 8912394-12 1996 Whereas in adult mammalian brain activity for hydrolysis of ATP and ADP may be associated with nerve cells or glial cells 5"-nucleotidase appears to have a preferential glial allocation in the adult mammal. Adenosine Diphosphate 68-71 5'-nucleotidase ecto Homo sapiens 122-137 8688446-2 1996 Results of mutagenesis and selection of spontaneous second-site revertants of the yeast ADP/ATP carrier AAC2 is described. Adenosine Diphosphate 88-91 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 104-108 8670798-2 1996 In the presence of hsp70 (hsc70), hdj-1 and either ATP or ADP, denatured beta-galactosidase refolds and forms enzymatically active tetramers. Adenosine Diphosphate 58-61 galactosidase beta 1 Homo sapiens 73-91 8666796-6 1996 In addition, mouse Rt6 but not rat RT6, catalyzes the ADP ribosylation of exogenous acceptors such as histones. Adenosine Diphosphate 54-57 ADP-ribosyltransferase 2a Mus musculus 19-22 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 4-7 ADP-ribosyltransferase 2a Mus musculus 135-138 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 38-41 ADP-ribosyltransferase 2a Mus musculus 135-138 8666796-7 1996 The ADP-ribosyl-protein bonds in auto-ADP-ribosylated rat RT6.2, auto-ADP-ribosylated mouse Rt6, and ADP-ribosylhistone synthesized by Rt6 were stable to HgCl2 and HCl, but labile to NH2OH, consistent with ADP ribosylarginine linkages. Adenosine Diphosphate 38-41 ADP-ribosyltransferase 2a Mus musculus 135-138 8639576-5 1996 Like native kinesin and K401, K341 and K366 demonstrate low ATPase activity in the absence of microtubules (0.03 and 0.01 s-1, respectively), and ADP release is rate-limiting during steady-state turnover. Adenosine Diphosphate 146-149 Kinesin heavy chain Drosophila melanogaster 12-19 8963722-3 1996 Freshly prepared gel-filtered platelets from healthy donors were incubated for 30 minutes at 37 degrees C with various concentrations of Lp(a); aggregation was triggered with ADP, thrombin, and collagen. Adenosine Diphosphate 175-178 lipoprotein(a) Homo sapiens 137-142 7501027-0 1995 A 32 degree tail swing in brush border myosin I on ADP release. Adenosine Diphosphate 51-54 myosin IA Homo sapiens 26-47 7490513-0 1995 An aldose reductase inhibitor, TAT, reduces ADP-induced platelet hyperaggregation in streptozotocin-induced diabetic rats with neuropathy. Adenosine Diphosphate 44-47 aldo-keto reductase family 1 member B1 Rattus norvegicus 3-19 7563092-9 1995 Besides NOEs to the arginine residue participating in the conformational change, ADP-1 shows additional intermolecular NOEs to TAR, suggesting that there are multiple points of contacts between TAR RNA and residues from the basic and core regions of Tat. Adenosine Diphosphate 81-84 tyrosine aminotransferase Homo sapiens 250-253 7631008-6 1995 Radiolabeling of control and irradiated samples with [32P]NAD or [32P]orthophosphoric acid revealed the acidic species of B23 to be both ADP-ribosylated and phosphorylated. Adenosine Diphosphate 137-140 nucleophosmin 1 Homo sapiens 122-125 7631008-7 1995 Therefore, exposure of SQ-20B cells to radiation results in the increase in expression of an ADP-ribosylated and phosphorylated species of B23. Adenosine Diphosphate 93-96 nucleophosmin 1 Homo sapiens 139-142 7542236-3 1995 When platelets were aggregated with TRAP or ADP, CDC42Hs (10% of total) appeared in the cytoskeleton and decreased in the membrane skeleton, whereas RhoGDI (guanine-nucleotide dissociation inhibitor) and CDC42HsGAP (GTPase-activating protein) remained exclusively in the detergent-soluble fraction. Adenosine Diphosphate 44-47 cell division cycle 42 Homo sapiens 49-56 7542236-3 1995 When platelets were aggregated with TRAP or ADP, CDC42Hs (10% of total) appeared in the cytoskeleton and decreased in the membrane skeleton, whereas RhoGDI (guanine-nucleotide dissociation inhibitor) and CDC42HsGAP (GTPase-activating protein) remained exclusively in the detergent-soluble fraction. Adenosine Diphosphate 44-47 cell division cycle 42 Homo sapiens 49-54 7542236-9 1995 The results indicate that in platelets stimulated by TRAP or ADP, a fraction of CDC42Hs translocates from the membrane skeleton to the cytoskeleton. Adenosine Diphosphate 61-64 cell division cycle 42 Homo sapiens 80-87 7601144-3 1995 Following previous indications that the interaction of CSA with the pore is inhibited by Ca2+ and promoted by ADP, we have investigated how covalent labelling of heart mitochondria by a photoactive CSA derivative is influenced by these agents. Adenosine Diphosphate 110-113 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 55-58 7758459-0 1995 Expression of the AAC2 gene encoding the major mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is controlled at the transcriptional level by oxygen, heme and HAP2 factor. Adenosine Diphosphate 61-64 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 18-22 7758459-1 1995 Expression of the Saccharomyces cerevisiae AAC2 gene encoding the major mitochondrial ADP/ATP carrier was examined. Adenosine Diphosphate 86-89 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 43-47 7482433-5 1995 The extent of enhancement was 2.78 times by 7.5 microM of ADP and 44 times by 0.5 microgram/ml of collagen in the presence of RLP-preparation 1 (RLP-1), respectively. Adenosine Diphosphate 58-61 phospholipase A and acyltransferase 5 Homo sapiens 126-143 7482433-5 1995 The extent of enhancement was 2.78 times by 7.5 microM of ADP and 44 times by 0.5 microgram/ml of collagen in the presence of RLP-preparation 1 (RLP-1), respectively. Adenosine Diphosphate 58-61 phospholipase A and acyltransferase 5 Homo sapiens 145-150 7482433-6 1995 In the presence of RLP-2, the enhancement was 5.37 times by 7.5 microM of ADP and 102 times by 0.5 microgram/ml of collagen, respectively. Adenosine Diphosphate 74-77 Rab interacting lysosomal protein like 2 Homo sapiens 19-24 7482433-8 1995 Inhibitions were 19% by 7.5 microM of ADP and 18% by 1.0 microgram/of collagen in the presence of RLP-1, respectively. Adenosine Diphosphate 38-41 phospholipase A and acyltransferase 5 Homo sapiens 98-103 7787062-4 1995 In the steady state, kinesin has a low ATPase activity that is limited by the rate of ADP release (< 0.01 s-1) in the absence of microtubules and is activated 2000-fold by the addition of microtubules to achieve a maximum rate of approximately 20 s-1. Adenosine Diphosphate 86-89 dynein axonemal heavy chain 8 Homo sapiens 39-45 7495081-9 1995 In addition to their capacity to aggregate in the presence of fibrinogen alone, plasmin-treated platelets also show a potentiated aggregability in response to low doses of ADP. Adenosine Diphosphate 172-175 plasminogen Homo sapiens 80-87 7757200-5 1995 NADH and ADP (not NAD+ or ATP) enhanced LADH inactivation by Cu(II). Adenosine Diphosphate 9-12 dihydrolipoamide dehydrogenase Sus scrofa 40-44 7867790-3 1995 Here we show that SAP90 specifically binds GMP in the micromolar range while binding to ATP, GDP and ADP is at a much lower affinity (10-25 mM), whether or not binding is detected for other guanine and adenine nucleotides. Adenosine Diphosphate 101-104 discs large MAGUK scaffold protein 4 Homo sapiens 18-23 7736606-1 1995 A mutation (op1) in the Saccharomyces cerevisiae AAC2 gene, which codes for the most abundant ADP/ATP carrier isoform, results in lack of mitochondrial-dependent growth and in an as yet unexplained petite-negative phenotype. Adenosine Diphosphate 94-97 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 49-53 7827022-9 1995 These data showed that the entire catalytic mechanism for ADP-ribosylation resides within the first 180 amino acids of S1 and that the carboxyl-terminal 55 residues of S1 allow the ADP-ribosylation of alpha i3C20 to proceed via Michaelis-Menten kinetics. Adenosine Diphosphate 181-184 retinoschisin 1 Rattus norvegicus 168-170 7822295-2 1995 Pseudomonas aeruginosa exotoxin A (ETA) is a member of the family of bacterial ADP-ribosylating toxins which use NAD+ as the ADP-ribose donor. Adenosine Diphosphate 79-82 endothelin receptor type A Homo sapiens 23-33 7822295-2 1995 Pseudomonas aeruginosa exotoxin A (ETA) is a member of the family of bacterial ADP-ribosylating toxins which use NAD+ as the ADP-ribose donor. Adenosine Diphosphate 79-82 endothelin receptor type A Homo sapiens 35-38 7660136-2 1995 We have investigated the effects of Mg2+ (added to platelet rich plasma [PRP] as 10mM MgCl2 or MgSO4) on the platelet aggregation and actin polymerization that occurs in response to adenosine diphosphate (ADP). Adenosine Diphosphate 182-203 mucin 7, secreted Homo sapiens 36-39 7660136-6 1995 Mg2+ added after inducing platelet aggregation with 10 microM ADP produced parallel disaggregation of platelets and actin depolymerization. Adenosine Diphosphate 62-65 mucin 7, secreted Homo sapiens 0-3 7721724-4 1994 In the presence of NADH and ADP an additional enhancement of k-1 was observed. Adenosine Diphosphate 28-31 keratin 1 Homo sapiens 61-64 7886693-9 1994 These results suggest that L-amino acid oxidase induces human platelet aggregation through the formation of H2O2, and subsequent thromboxane A2 synthesis requiring Ca2+ but independent of ADP release. Adenosine Diphosphate 188-191 interleukin 4 induced 1 Homo sapiens 27-47 8074172-7 1994 By preventing local accumulation of ADP, generated in ATPase reactions, CK-CP system also inhibited Ca2+ efflux under conditions in which this efflux was stimulated by the increase of free Ca2+ inside vesicles. Adenosine Diphosphate 36-39 ATPase Na+/K+ transporting subunit beta 1 Homo sapiens 54-60 7994982-8 1994 A significant decrease was observed in the collagen- and ADP-induced platelet aggregation and markers for platelet activation such as platelet factor 4 (PF4) and beta-thromboglobulin (beta TG) by the antiplatelet therapy. Adenosine Diphosphate 57-60 platelet factor 4 Homo sapiens 153-156 7994982-8 1994 A significant decrease was observed in the collagen- and ADP-induced platelet aggregation and markers for platelet activation such as platelet factor 4 (PF4) and beta-thromboglobulin (beta TG) by the antiplatelet therapy. Adenosine Diphosphate 57-60 pro-platelet basic protein Homo sapiens 184-191 8041710-1 1994 The N-terminal 392 amino acids of the Drosophila kinesin alpha subunit (designated DKH392) form a dimer in solution that releases only one of its two tightly bound ADP molecules on association with a microtubule, whereas a shorter monomeric construct (designated DKH340) releases > or = 95% of its one bound ADP on association with a microtubule. Adenosine Diphosphate 164-167 Kinesin heavy chain Drosophila melanogaster 49-70 8041710-1 1994 The N-terminal 392 amino acids of the Drosophila kinesin alpha subunit (designated DKH392) form a dimer in solution that releases only one of its two tightly bound ADP molecules on association with a microtubule, whereas a shorter monomeric construct (designated DKH340) releases > or = 95% of its one bound ADP on association with a microtubule. Adenosine Diphosphate 311-314 Kinesin heavy chain Drosophila melanogaster 49-70 7974388-3 1994 In canine platelet rich plasma Ac-RGDS-NH2 produced a concentration related inhibition of adenosine diphosphate-induced platelet aggregation following preincubation for 3 min with an IC50 of 91 +/- 1 microM. Adenosine Diphosphate 90-111 ral guanine nucleotide dissociation stimulator Homo sapiens 34-38 8168972-3 1994 In a linear velocity assay, the specific activity of C180 was 2% and that of C204 was 80% of the activity displayed by rS1 in catalyzing the ADP-ribosylation of Gt. Adenosine Diphosphate 141-144 retinoschisin 1 Rattus norvegicus 119-122 8142378-1 1994 In the presence of ADP and fluorometals, the ATPase activity of the catalytic sector, F1, of beef heart mitochondrial ATPase is strongly inhibited; this inhibition is dependent on the entrapment of ADP-fluoroaluminate complexes into the nucleotide binding sites of F1 [Lunardi, J., Dupuis, A., Garin, J., Issartel, J. P., Michel, L., Chabre, M., & Vignais, P. V. (1988) Proc. Adenosine Diphosphate 19-22 ATP synthase F1 subunit epsilon Homo sapiens 104-124 8821708-3 1994 With this isoform, the Km values were estimated to be 330 mumol/l for NAD and 30 mumol/l for MBP, and the optimal pH for ADP-ribosylation was 8.5. Adenosine Diphosphate 121-124 myelin basic protein Gallus gallus 93-96 8821708-4 1994 The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP. Adenosine Diphosphate 21-24 myelin basic protein Gallus gallus 57-60 8821708-4 1994 The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP. Adenosine Diphosphate 21-24 myelin basic protein Gallus gallus 91-94 8821708-4 1994 The stoichiometry of ADP-ribose incorporation into 21-kD MBP was 3.5 mol of ADP-ribose/mol MBP. Adenosine Diphosphate 76-79 myelin basic protein Gallus gallus 57-60 8107285-3 1994 Even if whole blood was pretreated with both acetylsalicylic acid (aspirin, ASA) and CP/CPK (creatine phosphate and creatine phosphokinase) to inhibit arachidonic acid metabolites products in the cyclooxygenase pathway and ADP, whole blood aggregation was induced by collagen in a concentration-dependent manner. Adenosine Diphosphate 223-226 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 88-91 8394137-4 1993 These results indicate that ecto-NADase may have a role as supplier of ADP-ribose for its uptake into the cells and that the cleavage of NAD by NADase is necessary for the ADP-ribose uptake by human erythrocytes. Adenosine Diphosphate 71-74 tripartite motif containing 33 Homo sapiens 28-32 8509398-15 1993 These results indicate that both S1 subunit which is bound to the B oligomer as well as dissociated S1 subunit are capable of catalyzing the ADP-ribosylation of Gt. Adenosine Diphosphate 141-144 retinoschisin 1 Rattus norvegicus 33-35 8509398-15 1993 These results indicate that both S1 subunit which is bound to the B oligomer as well as dissociated S1 subunit are capable of catalyzing the ADP-ribosylation of Gt. Adenosine Diphosphate 141-144 retinoschisin 1 Rattus norvegicus 100-102 8476415-3 1993 The intrinsic fluorescence of the Anc2 protein was specifically and rapidly enhanced upon addition of the transportable nucleotides ADP and ATP. Adenosine Diphosphate 132-135 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 34-38 8476415-6 1993 The ANC2-specific yeast stain offers the means to study a single ADP/ATP carrier, with a well-defined amino acid sequence, suitable for analysis of substrate- or inhibitor-induced conformational changes. Adenosine Diphosphate 65-68 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 4-8 8385945-3 1993 In contrast, ADP-ribosylation of human platelet membranes and of recombinant rhoB was inhibited by the detergent. Adenosine Diphosphate 13-16 ras homolog family member B Homo sapiens 77-81 8392699-3 1993 The ADP removing enzyme system creatine phosphate/creatine phosphokinase (CP/CPK) and the ADP receptor antagonist ATP alpha S strongly inhibited platelet aggregation in response to low doses of TRA, indicating that TRA-induced platelet aggregation, like thrombin-induced aggregation is an ADP mediated event. Adenosine Diphosphate 4-7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 77-80 7684600-4 1993 Surprisingly, the platelets that contained phosphorylated rap1B were found to respond fully to activation by a wide variety of stimuli: aggregation upon stimulation by collagen, phorbol ester, vasopressin, ADP, epinephrine, and ATP-secretion from dense granules induced by collagen, thrombin-receptor activating peptide, vasopressin and phorbol ester were unchanged as compared to control. Adenosine Diphosphate 206-209 RAP1B, member of RAS oncogene family Homo sapiens 58-63 8436590-7 1993 Moreover, the sperm-induced cytoplasmic division of Xenopus embryos was inhibited by microinjection into the embryos of the rhoA p21 pre-ADP-ribosylated by C3 which might serve as a dominant negative inhibitor of endogenous rho p21. Adenosine Diphosphate 137-140 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 129-132 8436590-7 1993 Moreover, the sperm-induced cytoplasmic division of Xenopus embryos was inhibited by microinjection into the embryos of the rhoA p21 pre-ADP-ribosylated by C3 which might serve as a dominant negative inhibitor of endogenous rho p21. Adenosine Diphosphate 137-140 cyclin-dependent kinase inhibitor 1A L homeolog Xenopus laevis 228-231 1334080-6 1992 Phosducin also inhibited the pertussis toxin-catalyzed ADP-ribosylation of transducin, indicating that the interaction between the T alpha and T beta gamma subunits of transducin was interrupted upon binding of phosducin. Adenosine Diphosphate 55-58 phosducin Bos taurus 0-9 1335068-8 1992 The direct relation between the NPY receptor and the PTX-sensitive G-protein was further shown by the ability of NPY to inhibit PTX-catalyzed in vitro ADP-ribosylation. Adenosine Diphosphate 151-154 neuropeptide Y Bos taurus 32-35 1335068-8 1992 The direct relation between the NPY receptor and the PTX-sensitive G-protein was further shown by the ability of NPY to inhibit PTX-catalyzed in vitro ADP-ribosylation. Adenosine Diphosphate 151-154 neuropeptide Y Bos taurus 113-116 1403950-4 1992 The ADP was found to be composed of a selectively adsorbed layer containing salivary amylase, high molecular weight mucin (MG1), lysozyme, albumin, and sIgA. Adenosine Diphosphate 4-7 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 123-126 1327767-3 1992 In insulin-secreting cells, rho protein(s) that cannot be detected with the GTP-binding technique were identified by ADP ribosylation with Clostridium botulinum C3 exoenzyme. Adenosine Diphosphate 117-120 insulin Mesocricetus auratus 3-10 1639862-9 1992 These observations may implicate a role of cellular ADP-ribosylation in the regulation of some gene expression by TGF-beta. Adenosine Diphosphate 52-55 transforming growth factor beta 1 Bos taurus 114-122 1577193-6 1992 The acetylcholine-induced ZP2 conversion, however, is not inhibited by pertussis toxin under conditions in which greater than 90% of the endogenous Gi is inactivated by ADP ribosylation. Adenosine Diphosphate 169-172 zona pellucida glycoprotein 2 Mus musculus 26-29 1317440-14 1992 The ADP-induced increase in [Ca2+]i was antagonized by the presence of prostaglandin E1 (PGE1, 100-1000 nM), in the medium, and by direct injection of cyclic AMP (100-500 microM) or cyclic GMP (500 microM) into the megakaryocyte. Adenosine Diphosphate 4-7 5'-nucleotidase, cytosolic II Mus musculus 189-192 1317440-24 1992 Injection of cyclic AMP or cyclic GMP reduced ADP-induced increases in [Ca2+]i under conditions of inhibited Ca2+ influx by NiCl2 (5 mM). Adenosine Diphosphate 46-49 5'-nucleotidase, cytosolic II Mus musculus 34-37 1579893-5 1992 ADP-induced platelet adhesion to collagen was almost completely inhibited by anti-GPIa/IIa and anti-GPIIa antibodies. Adenosine Diphosphate 0-3 platelet and endothelial cell adhesion molecule 1 Homo sapiens 100-105 1505279-6 1992 drips given to patients with PIH also inhibited ADP-induced platelet aggregation. Adenosine Diphosphate 48-51 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 29-32 1906886-7 1991 The results of this study suggest that 1) RGDS peptide receptor occupancy does not lead to GPIIb-IIIa linkage to the cytoskeleton, 2) ADP-stimulated platelet shape change, polymerization of actin, and association of myosin with the cytoskeleton are unaffected by RGDS peptide receptor occupancy. Adenosine Diphosphate 134-137 ral guanine nucleotide dissociation stimulator Homo sapiens 42-46 32858341-3 2020 Using an Ncr1Cre-based conditional knockout mouse, we found that PGC-1alpha was crucial for optimal NK cell effector functions and bioenergetics, as the deletion of PGC-1alpha was associated with decreased cytotoxic potential and cytokine production along with altered ADP/ATP ratios. Adenosine Diphosphate 269-272 PPARG coactivator 1 alpha Sus scrofa 65-75 1676683-7 1991 ADP inhibits TGase activity to the same extent as ATP, but AMP causes much less inhibition, and there is no inhibition by adenosine or adenine. Adenosine Diphosphate 0-3 transglutaminase 1 Homo sapiens 13-18 32453425-6 2020 DNA binding correlates with nucleotide occupancy: five MCM subunits are bound to either ATPgammaS or ADP, whereas the apo MCM2-5 interface remains open. Adenosine Diphosphate 101-104 minichromosome maintenance complex component 7 Homo sapiens 55-58 1829528-5 1991 Fluxes through the ATP in equilibrium ADP + Pi cycle were extremely well regulated; at the lower limit, the forward flux exceeded the backward flux by only 0.06%, whereas at the upper limit, ATPase rates exceeded ATP synthesis rates by 0.12%. Adenosine Diphosphate 38-43 dynein axonemal heavy chain 8 Homo sapiens 191-197 32454061-2 2020 The primary function of ANT proteins is to exchange cytosolic ADP with matrix ATP, facilitating the export of newly synthesized ATP to the cell while providing new ADP substrate to the mitochondria. Adenosine Diphosphate 62-65 solute carrier family 25 member 6 Homo sapiens 24-27 32454061-2 2020 The primary function of ANT proteins is to exchange cytosolic ADP with matrix ATP, facilitating the export of newly synthesized ATP to the cell while providing new ADP substrate to the mitochondria. Adenosine Diphosphate 164-167 solute carrier family 25 member 6 Homo sapiens 24-27 32464678-2 2020 ADP, either derived from red blood cells or released by platelets themselves, stimulates platelets via two G protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 136-140 32365477-0 2020 A Fluorescence-Based Method to Measure ADP/ATP Exchange of Recombinant Adenine Nucleotide Translocase in Liposomes. Adenosine Diphosphate 39-42 solute carrier family 25 member 6 Homo sapiens 71-101 32365477-6 2020 We obtained an ADP/ATP exchange rate of 3.49 +- 0.41 mmol/min/g of recombinant ANT1 reconstituted into unilamellar liposomes, which is comparable to values measured in mitochondria and proteoliposomes using a radioactivity assay. Adenosine Diphosphate 15-18 solute carrier family 25 member 4 Homo sapiens 79-83 32365477-7 2020 ADP/ATP exchange calculated from MgGrTM fluorescence solely depends on the ANT1 content in liposomes and is inhibited by the ANT-specific inhibitors, bongkrekic acid and carboxyatractyloside. Adenosine Diphosphate 0-3 solute carrier family 25 member 4 Homo sapiens 75-79 32365477-7 2020 ADP/ATP exchange calculated from MgGrTM fluorescence solely depends on the ANT1 content in liposomes and is inhibited by the ANT-specific inhibitors, bongkrekic acid and carboxyatractyloside. Adenosine Diphosphate 0-3 solute carrier family 25 member 6 Homo sapiens 75-78 32365477-8 2020 The application of MgGrTM to investigate ADP/ATP exchange rates contributes to our understanding of ANT function in mitochondria and paves the way for the design of other substrate transport assays. Adenosine Diphosphate 41-44 solute carrier family 25 member 6 Homo sapiens 100-103 1647210-7 1991 The ATP/ADP and GTP/GDP ratios were almost identical in control and in pIND25-2 transformed strains growing in glucose and in galactose, while the strain that overexpresses the 3" terminal portion of CDC25 gene showed a decrease of ATP/ADP ratio and a partial depletion of the GTP pool. Adenosine Diphosphate 8-11 Ras family guanine nucleotide exchange factor CDC25 Saccharomyces cerevisiae S288C 200-205 32328457-5 2020 GDH sigmoidal kinetics with NH 4 + , ADP, and leucine fitted to Hill equation showed n H values of 2 to 3. Adenosine Diphosphate 40-43 glutamate dehydrogenase 1 Homo sapiens 0-3 1647210-7 1991 The ATP/ADP and GTP/GDP ratios were almost identical in control and in pIND25-2 transformed strains growing in glucose and in galactose, while the strain that overexpresses the 3" terminal portion of CDC25 gene showed a decrease of ATP/ADP ratio and a partial depletion of the GTP pool. Adenosine Diphosphate 236-239 Ras family guanine nucleotide exchange factor CDC25 Saccharomyces cerevisiae S288C 200-205 1902090-4 1991 EGF enhances cholera toxin- (CT) mediated ADP-ribosylation of all three 40/41 kDa Gi-proteins as well as of five 45 and four 48/50 kDa proteins, which had been previously identified as Gs-proteins (2), whereas insulin has no effect. Adenosine Diphosphate 42-45 epidermal growth factor like 1 Rattus norvegicus 0-3 31911551-0 2020 Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation. Adenosine Diphosphate 66-69 tumor protein p53 binding protein 1 Homo sapiens 33-38 31911551-0 2020 Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation. Adenosine Diphosphate 66-69 tumor protein p53 binding protein 1 Homo sapiens 60-65 31911551-6 2020 In response to DNA damage, ADP-ribosylated 53BP1 increased significantly, resulting in its ubiquitination and degradation. Adenosine Diphosphate 27-30 tumor protein p53 binding protein 1 Homo sapiens 43-48 1704263-2 1991 In the present study, we addressed the question as to whether, in the more physiologic milieu of whole blood, downregulation of platelet surface GPIb and GPIX can be induced by thrombin, adenosine diphosphate (ADP), and/or by an in vivo wound. Adenosine Diphosphate 187-208 glycoprotein IX platelet Homo sapiens 154-158 31911551-10 2020 In summary, we demonstrate that NUDT16 regulates 53BP1 stability and 53BP1 recruitment at double-strand breaks, providing yet another mechanism of 53BP1 regulation.Significance: This study provides a novel mechanism of 53BP1 regulation by demonstrating that NUDT16 has hydrolase activities that remove ADP-ribosylation of 53BP1 to regulate 53BP1 stability and 53BP1 localization at DSBs. Adenosine Diphosphate 302-305 tumor protein p53 binding protein 1 Homo sapiens 49-54 31883448-4 2020 ATP and AMP hydrolysis was decreased by Met (1 and 2 mM), Met-SO and Met (1 and 2 mM) + Met-SO treatment, while ADP hydrolysis was enhanced by Met-SO and Met (1 and 2 mM) + Met-SO (P < 0.05). Adenosine Diphosphate 112-115 granzyme M Homo sapiens 143-169 32067141-3 2020 Similarly, signalling through P2Y12 and P2Y13 receptors coupled to Gi/o proteins is initiated by the ATP breakdown product ADP. Adenosine Diphosphate 123-126 purinergic receptor P2Y12 Rattus norvegicus 30-35 1987450-6 1991 Inhibitors of TS PST enzymatic activity, including 3"-phosphoadenosine-5"-phosphate, ATP, ADP, and 2,6-dichloro-4-nitrophenol, also inhibited photoaffinity labeling of the 35-kDa protein with [35S]PAPS, in a concentration-dependent fashion, with IC50 values of 14 microM, 2.1 mM, 7.7 mM, and 91 microM, respectively. Adenosine Diphosphate 90-93 sulfotransferase family 1A member 1 Homo sapiens 14-20 32067141-4 2020 Hence, this study has pharmacologically investigated a possible role of ADP-induced inhibition of the cardioaccelerator sympathetic drive in pithed rats, using a stable ADP analogue (ADPbetaS) and selective antagonists for the purinergic P2Y1, P2Y12 and P2Y13 receptors. Adenosine Diphosphate 72-75 purinergic receptor P2Y12 Rattus norvegicus 244-249 2096889-6 1990 Formation of various binary, ternary and quaternary complexes of bovine liver glutamate dehydrogenase (GDH) with glutamate, NADPH, NADH, and ADP was also investigated using immobilized GDH. Adenosine Diphosphate 125-128 glutamate dehydrogenase 1, mitochondrial Bos taurus 78-101 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 196-199 myosin heavy chain 14 Homo sapiens 57-63 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 196-199 myosin heavy chain 14 Homo sapiens 89-95 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 196-199 myosin heavy chain 14 Homo sapiens 89-95 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 211-214 myosin heavy chain 14 Homo sapiens 57-63 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 211-214 myosin heavy chain 14 Homo sapiens 89-95 32069889-1 2020 It is generally believed that during muscle contraction, myosin heads (M) extending from myosin filament attaches to actin filaments (A) to perform power stroke, associated with the reaction, A-M-ADP-Pi A-M + ADP + Pi, so that myosin heads pass through the state of A-M, i.e., rigor A-M complex. Adenosine Diphosphate 211-214 myosin heavy chain 14 Homo sapiens 89-95 32069889-3 2020 These results suggest that A-M-ADP myosin heads in high-Ca rigor fibers have dynamic properties to produce the tension recovery following ramp-shaped releases, and that myosin heads do not pass through rigor A-M complex configuration during muscle contraction. Adenosine Diphosphate 31-34 myosin heavy chain 14 Homo sapiens 35-41 32046066-3 2020 It has been shown that TRPM2 cation channels and CD38, a type II or type III transmembrane protein with ADP-ribosyl cyclase activity, simultaneously play a role in heat-sensitive and NAD+ metabolite-dependent intracellular free Ca2+ concentration increases in hypothalamic oxytocinergic neurons. Adenosine Diphosphate 104-107 CD38 molecule Homo sapiens 49-53 32451855-4 2020 Most recently, reconstructions of actin filaments decorated with different myosins, which show a strongly bound acto-myosin complex also in the presence of the nucleotide ADP, have become available. Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 75-81 2096889-6 1990 Formation of various binary, ternary and quaternary complexes of bovine liver glutamate dehydrogenase (GDH) with glutamate, NADPH, NADH, and ADP was also investigated using immobilized GDH. Adenosine Diphosphate 125-128 glutamate dehydrogenase 1, mitochondrial Bos taurus 103-106 32034708-2 2020 P2Y1 and P2Y12 both respond to ADP, but while P2Y1 links to PLC and elevates cytosolic Ca2+ concentration, P2Y12 negatively couples to adenylate cyclase, maintaining cAMP at low level. Adenosine Diphosphate 31-34 purinergic receptor P2Y1 Homo sapiens 0-4 32034708-2 2020 P2Y1 and P2Y12 both respond to ADP, but while P2Y1 links to PLC and elevates cytosolic Ca2+ concentration, P2Y12 negatively couples to adenylate cyclase, maintaining cAMP at low level. Adenosine Diphosphate 31-34 purinergic receptor P2Y1 Homo sapiens 9-13 2118945-1 1990 Pretreatment of striatal neurons from mouse embryos in primary culture with 17 beta-estradiol (10(-9) M, 24 h) enhanced the ADP-ribosylation of G alpha o,i proteins catalyzed by pertussis toxin (PTX). Adenosine Diphosphate 124-127 guanine nucleotide binding protein, alpha O Mus musculus 144-153 31514105-9 2020 Circulating OPN levels were positively correlated with CRP, age, BMI, SBP, DBP, HbA1c, UA, TGs, WBCs, neutrophils, FBG, and HOMA-IR and negatively correlated with ADP, albumin and HDL. Adenosine Diphosphate 163-166 secreted phosphoprotein 1 Homo sapiens 12-15 2166901-7 1990 Cys(Npys) blocked [35S]GTP gamma S binding as well as IAP-catalyzed ADP-ribosylation in purified Go. Adenosine Diphosphate 68-71 Cd47 molecule Rattus norvegicus 54-57 31812083-1 2020 CHFR is a tumor suppressor that not only recognizes poly(ADP-ribosylation) (PARylation) signals at the sites of DNA damage but also is downregulated in many types of cancer. Adenosine Diphosphate 52-74 checkpoint with forkhead and ring finger domains Homo sapiens 0-4 2231747-5 1990 This mainly lysosomal 5"-nucleotidase activity was 61% inhibited by the alpha,beta-methylene analog of ADP, indicating that although the latter has been considered specific to the plasma membrane enzyme, it also inhibits the lysosomal enzyme. Adenosine Diphosphate 103-106 5'-nucleotidase ecto Homo sapiens 22-37 31812083-1 2020 CHFR is a tumor suppressor that not only recognizes poly(ADP-ribosylation) (PARylation) signals at the sites of DNA damage but also is downregulated in many types of cancer. Adenosine Diphosphate 76-86 checkpoint with forkhead and ring finger domains Homo sapiens 0-4 2161185-6 1990 RESULTS: There was a positive correlation with age for both adenosine diphosphate (ADP)-induced aggregation (1.25 microM, r = 0.464, p less than 0.001; 2.5 microM, r = 0.386, p less than 0.05) and plasma beta-TBG (r = 0.381, p less than 0.055). Adenosine Diphosphate 60-81 pro-platelet basic protein Homo sapiens 204-212 31701800-4 2019 Platelet activation stimulated by adenosine diphosphate (ADP) in the presence or absence of abeta2GPI was measured by the expression of P-selectin on platelet surface using flow cytometry. Adenosine Diphosphate 57-60 selectin P Homo sapiens 136-146 31701800-6 2019 When stimulated using abeta2GPI combined with ADP, P-selectin expression (28.42 +- 5.15% vs. 20.98 +- 3.94%, p = 0.0076) was significantly higher than ADP alone. Adenosine Diphosphate 46-49 selectin P Homo sapiens 51-61 2161185-6 1990 RESULTS: There was a positive correlation with age for both adenosine diphosphate (ADP)-induced aggregation (1.25 microM, r = 0.464, p less than 0.001; 2.5 microM, r = 0.386, p less than 0.05) and plasma beta-TBG (r = 0.381, p less than 0.055). Adenosine Diphosphate 83-86 pro-platelet basic protein Homo sapiens 204-212 2153112-1 1990 According to recent observations ADP stimulates platelets via activation of Na+/H+ exchange which increases cytosolic pH (pHi). Adenosine Diphosphate 33-36 glucose-6-phosphate isomerase Homo sapiens 122-125 31770438-5 2019 Decreased aggregation and secretion were rescued by exogenous adenosine 5"-diphosphate, indicating that AADACL1 likely functions to induce dense granule secretion. Adenosine Diphosphate 62-86 neutral cholesterol ester hydrolase 1 Homo sapiens 104-111 31745227-1 2019 Choline kinase alpha is a 457-residue protein that catalyzes the reaction between ATP and choline to yield ADP and phosphocholine. Adenosine Diphosphate 107-110 choline kinase alpha Homo sapiens 0-20 2153112-4 1990 We found that ADP (5 microM) increased pHi from 7.15 +/- 0.08 to 7.35 +/- 0.04 (n = 8) in 2"-7"-bis-(carboxyethyl)-5,6-carboxyfluorescein-loaded platelets, whereas thromboxane A2 formation was inhibited by indomethacin. Adenosine Diphosphate 14-17 glucose-6-phosphate isomerase Homo sapiens 39-42 33944898-11 2021 Deletion of RASGRP2 impaired functional responses to adenosine 5"-diphosphate (ADP), thrombin, and collagen receptor agonists. Adenosine Diphosphate 79-82 RAS guanyl releasing protein 2 Homo sapiens 12-19 31582565-10 2019 Despite the lack of distinction between early and late onset HCM, the predicted occupancy of the force-holding actin myosin ADP complex at [Actin] = 3 K app along with the closely related duty ratio (the fraction of myosin in strongly attached force-holding states), and the measured ATPases all changed in parallel (in both sign and degree of change) compared with wildtype (WT) values. Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 117-123 33801677-1 2021 P2Y13 is an ADP-stimulated G-protein coupled receptor implicated in many physiological processes, including neurotransmission, metabolism, pain, and bone homeostasis. Adenosine Diphosphate 12-15 purinergic receptor P2Y13 Homo sapiens 0-5 30988430-6 2019 Mechanistically, PARP11 mono-ADP-ribosylates the ubiquitin E3 ligase beta-transducin repeat-containing protein (beta-TrCP). Adenosine Diphosphate 29-32 poly(ADP-ribose) polymerase family member 11 Homo sapiens 17-23 30988430-6 2019 Mechanistically, PARP11 mono-ADP-ribosylates the ubiquitin E3 ligase beta-transducin repeat-containing protein (beta-TrCP). Adenosine Diphosphate 29-32 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 69-110 30988430-6 2019 Mechanistically, PARP11 mono-ADP-ribosylates the ubiquitin E3 ligase beta-transducin repeat-containing protein (beta-TrCP). Adenosine Diphosphate 29-32 beta-transducin repeat containing E3 ubiquitin protein ligase Homo sapiens 112-121 30988430-8 2019 Moreover, PARP11 expression is upregulated by virus infections, including vesicular stomatitis virus, herpes simplex virus-1 and influenza A virus, thus promoting ADP-ribosylation-mediated viral evasion. Adenosine Diphosphate 163-166 poly(ADP-ribose) polymerase family member 11 Homo sapiens 10-16 31547977-1 2019 BACKGROUND: Dependent on the extent of adenosine triphosphate (ATP) hydrolysis and/or ATP/ADP exchange, the stress-induced phosphoprotein 1 (STIP1) mediates molecular interaction and complex formation between the molecular chaperones heat shock protein (Hsp)70 and Hsp90. Adenosine Diphosphate 90-93 stress induced phosphoprotein 1 Homo sapiens 108-139 31547977-1 2019 BACKGROUND: Dependent on the extent of adenosine triphosphate (ATP) hydrolysis and/or ATP/ADP exchange, the stress-induced phosphoprotein 1 (STIP1) mediates molecular interaction and complex formation between the molecular chaperones heat shock protein (Hsp)70 and Hsp90. Adenosine Diphosphate 90-93 stress induced phosphoprotein 1 Homo sapiens 141-146 31547977-1 2019 BACKGROUND: Dependent on the extent of adenosine triphosphate (ATP) hydrolysis and/or ATP/ADP exchange, the stress-induced phosphoprotein 1 (STIP1) mediates molecular interaction and complex formation between the molecular chaperones heat shock protein (Hsp)70 and Hsp90. Adenosine Diphosphate 90-93 heat shock protein 90 alpha family class A member 1 Homo sapiens 265-270 31591378-10 2019 In addition, P2Y12+ macrophages migrated towards the ADP-rich culture medium of puromycin-treated dying B16F1 melanoma cells. Adenosine Diphosphate 53-56 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 13-18 31387944-5 2019 The perinatal is distinct from the embryonic isoform, appearing to have features in common with the adult fast-muscle isoforms, including weak affinity of ADP for actin myosin and fast ADP release. Adenosine Diphosphate 155-158 myosin heavy chain 14 Homo sapiens 169-175 31402386-6 2019 Overall, the structure of the nucleotide-free ISWI-nucleosome complex is similar to the corresponding regions of the recently reported ADP bound ISWI-nucleosome structures, which are significantly different from that observed for the ADP-BeFx bound structure. Adenosine Diphosphate 135-138 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 46-50 31402386-6 2019 Overall, the structure of the nucleotide-free ISWI-nucleosome complex is similar to the corresponding regions of the recently reported ADP bound ISWI-nucleosome structures, which are significantly different from that observed for the ADP-BeFx bound structure. Adenosine Diphosphate 135-138 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 145-149 31402386-6 2019 Overall, the structure of the nucleotide-free ISWI-nucleosome complex is similar to the corresponding regions of the recently reported ADP bound ISWI-nucleosome structures, which are significantly different from that observed for the ADP-BeFx bound structure. Adenosine Diphosphate 234-237 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 46-50 31402386-6 2019 Overall, the structure of the nucleotide-free ISWI-nucleosome complex is similar to the corresponding regions of the recently reported ADP bound ISWI-nucleosome structures, which are significantly different from that observed for the ADP-BeFx bound structure. Adenosine Diphosphate 234-237 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 145-149 33801677-5 2021 For signaling events induced by heterologously expressed P2Y13, EC50 of ADP-like agonists was 17.2 nM (95% CI: 7.7-38.5), with Hills coefficient of 4.4 (95% CI: 3.3-5.4), while ATP-like agonists had EC50 of 0.45 muM (95% CI: 0.06-3.15). Adenosine Diphosphate 72-75 purinergic receptor P2Y13 Homo sapiens 57-62 33801677-6 2021 For functional responses of endogenously expressed P2Y13, EC50 of ADP-like agonists was 1.76 muM (95% CI: 0.3-10.06). Adenosine Diphosphate 66-69 purinergic receptor P2Y13 Homo sapiens 51-56 33801677-7 2021 The EC50 of ADP-like agonists was lower for the brain P2Y13 than the blood P2Y13. Adenosine Diphosphate 12-15 purinergic receptor P2Y13 Homo sapiens 54-59 33801677-7 2021 The EC50 of ADP-like agonists was lower for the brain P2Y13 than the blood P2Y13. Adenosine Diphosphate 12-15 purinergic receptor P2Y13 Homo sapiens 75-80 33801677-8 2021 ADP-like agonists were also more potent for human P2Y13 compared to rodent P2Y13. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 50-55 33801677-8 2021 ADP-like agonists were also more potent for human P2Y13 compared to rodent P2Y13. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 75-80 33801677-9 2021 Thus, P2Y13 appears to be the most ADP-sensitive receptor characterized to date. Adenosine Diphosphate 35-38 purinergic receptor P2Y13 Homo sapiens 6-11 33801677-10 2021 The detailed understanding of tissue- and species-related differences in the P2Y13 response to ADP will improve the selectivity and specificity of future pharmacological compounds. Adenosine Diphosphate 95-98 purinergic receptor P2Y13 Homo sapiens 77-82 33763084-7 2021 Indeed, binding of IFN-gamma to IFNR1 blocks ADP-ribosylation of IFN-gamma. Adenosine Diphosphate 45-48 interferon (alpha and beta) receptor 1 Mus musculus 32-37 34592041-5 2022 RESULTS: PDIA1 was less abundant compared to PDIA3 in resting platelets and platelets stimulated with TRAP-14, collagen or ADP. Adenosine Diphosphate 123-126 prolyl 4-hydroxylase subunit beta Homo sapiens 9-14 34878641-1 2022 BACKGROUND: The 5" adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that is activated by increases in the cellular AMP/adenosine diphosphate:adenosine triphosphate (ADP:ATP) ratios and plays a key role in metabolic adaptations to endurance training. Adenosine Diphosphate 206-209 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 75-79 34840926-8 2021 ATP, ADP, UTP, UDP and UDPG also induced osteoclastogenesis as evident from fused multinucleate cells and expression of osteoclast markers (TRAP, Cathepsin K (CTSK)) as determined by Q-PCR. Adenosine Diphosphate 5-8 cathepsin K Mus musculus 146-157 34840926-8 2021 ATP, ADP, UTP, UDP and UDPG also induced osteoclastogenesis as evident from fused multinucleate cells and expression of osteoclast markers (TRAP, Cathepsin K (CTSK)) as determined by Q-PCR. Adenosine Diphosphate 5-8 cathepsin K Mus musculus 159-163 34798070-4 2021 Our pull-down and isothermal titration calorimetry (ITC) based studies suggested that HSC70 binds to ARL5B in an ADP-dependent manner. Adenosine Diphosphate 113-116 ADP ribosylation factor like GTPase 5B Homo sapiens 101-106 34787456-9 2022 Adenosine phosphate analysis showed that AS activates AMPK via improving AMP/ADP:ATP ratio rather than direct interaction with AMPK. Adenosine Diphosphate 77-80 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 54-58 34832065-2 2021 Adenine nucleotide translocase 1 (ANT1) facilitates the transfer of ADP/ATP across the inner mitochondrial membrane; therefore, we tested whether ANT1 exerts protective effects on mitochondrial function during ischemia/reperfusion (I/R). Adenosine Diphosphate 68-71 solute carrier family 25 member 4 Rattus norvegicus 0-32 34832065-2 2021 Adenine nucleotide translocase 1 (ANT1) facilitates the transfer of ADP/ATP across the inner mitochondrial membrane; therefore, we tested whether ANT1 exerts protective effects on mitochondrial function during ischemia/reperfusion (I/R). Adenosine Diphosphate 68-71 solute carrier family 25 member 4 Rattus norvegicus 34-38 34832065-2 2021 Adenine nucleotide translocase 1 (ANT1) facilitates the transfer of ADP/ATP across the inner mitochondrial membrane; therefore, we tested whether ANT1 exerts protective effects on mitochondrial function during ischemia/reperfusion (I/R). Adenosine Diphosphate 68-71 solute carrier family 25 member 4 Rattus norvegicus 146-150 34580293-7 2021 Ssb, in a manner consistent with the ADP conformation, also crosslinks to ribosomal proteins across the tunnel exit from Zuo1. Adenosine Diphosphate 37-40 small RNA binding exonuclease protection factor La Homo sapiens 0-3 34580293-8 2021 These two modes of Hsp70 Ssb interaction at the ribosome suggest a functionally efficient interaction pathway: first, Ssb(ATP) with Ssz1, allowing optimal J-domain and nascent chain engagement; then, after ATP hydrolysis, Ssb(ADP) directly with the ribosome. Adenosine Diphosphate 226-229 small RNA binding exonuclease protection factor La Homo sapiens 222-225 34621170-1 2021 Objective: Adenine nucleotide translocase (ANT) can transport ADP from cytoplasm to mitochondrial matrix and provide raw materials for ATP synthesis by oxidative phosphorylation. Adenosine Diphosphate 62-65 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 11-41 34621170-1 2021 Objective: Adenine nucleotide translocase (ANT) can transport ADP from cytoplasm to mitochondrial matrix and provide raw materials for ATP synthesis by oxidative phosphorylation. Adenosine Diphosphate 62-65 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 43-46 34621170-2 2021 Dysfunction of ANT leads to limitation of ADP transport and decrease of ATP production. Adenosine Diphosphate 42-45 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 15-18 34621170-3 2021 Atractyloside (ATR) is considered as a cytotoxic competitive inhibitor binding to ANT, making ANT vulnerable to transport ADP, and reduces ATP synthesis. Adenosine Diphosphate 122-125 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 82-85 34621170-3 2021 Atractyloside (ATR) is considered as a cytotoxic competitive inhibitor binding to ANT, making ANT vulnerable to transport ADP, and reduces ATP synthesis. Adenosine Diphosphate 122-125 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 94-97 34621170-4 2021 Moreover, the blockage of ANT by ATR may increase ADP/ATP ratio, activate AMPK-mTORC1-autophagy signaling pathway, and promote lipid degradation in steatosis hepatocytes. Adenosine Diphosphate 50-53 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 26-29 34504490-1 2021 Mouse T cells express the ecto-ADP-ribosyltransferase ARTC2.2, which can transfer the ADP-ribose group of extracellular nicotinamide adenine dinucleotide (NAD+) to arginine residues of various cell surface proteins thereby influencing their function. Adenosine Diphosphate 86-89 ADP-ribosyltransferase 2a Mus musculus 54-59 34440004-6 2021 Specifically, the ATP/ADP ratio was significantly decreased in the neurites of Bcl-xL depleted neurons. Adenosine Diphosphate 22-25 Bcl2-like 1 Rattus norvegicus 79-85 34105986-10 2021 Dampening of these danger signals and organ protection largely depends upon activities of vascular and immune cell-expressed ectonucleotidases (CD39 and CD73), which convert ATP and ADP into anti-inflammatory adenosine. Adenosine Diphosphate 182-185 5'-nucleotidase ecto Homo sapiens 153-157 34402252-10 2021 ATP level in the SIK2 overexpression group was higher than that in the reperfusion group and adenovirus no-load group (all <0.05), and ADP was decreased in the SIK2 overexpression group (all <0.05). Adenosine Diphosphate 135-138 salt-inducible kinase 2 Rattus norvegicus 17-21 31409651-0 2019 Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release. Adenosine Diphosphate 125-128 DEAH-box helicase 8 Homo sapiens 65-69 31409651-3 2019 Our results reveal that DHX8 has an in vitro binding preference for adenine-rich RNA and that RNA binding triggers the release of ADP through significant conformational flexibility in the conserved DEAH-, P-loop and hook-turn motifs. Adenosine Diphosphate 130-133 DEAH-box helicase 8 Homo sapiens 24-28 30576423-4 2019 METHODS AND RESULTS: We demonstrated that FUNDC2 deficiency diminished platelet aggregation in response to a variety of agonists, including adenosine 5"-diphosphate (ADP), collagen, ristocetin/VWF, and thrombin. Adenosine Diphosphate 140-164 FUN14 domain containing 2 Mus musculus 42-48 30576423-4 2019 METHODS AND RESULTS: We demonstrated that FUNDC2 deficiency diminished platelet aggregation in response to a variety of agonists, including adenosine 5"-diphosphate (ADP), collagen, ristocetin/VWF, and thrombin. Adenosine Diphosphate 166-169 FUN14 domain containing 2 Mus musculus 42-48 31247148-5 2019 Here we screened a library of 390,000 compounds with an ADP-Glo assay using dephosphorylated ITK. Adenosine Diphosphate 56-59 IL2 inducible T cell kinase Homo sapiens 93-96 31434806-3 2019 ADP stimulated P2Y12 receptors, causing bladder smooth muscle (BSM) contraction, whereas adenosine signaling through potentially newly defined A2b receptors, actively inhibited BSM purinergic contractility. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 15-20 30689196-10 2019 Energy depletion and ADP elevation in sensory afferents, due to mitochondrial respiratory chain complex IV deficiency, appear sufficient to induce pain hypersensitivity, by ADP activation of P2Y1 receptors. Adenosine Diphosphate 21-24 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 191-195 30689196-10 2019 Energy depletion and ADP elevation in sensory afferents, due to mitochondrial respiratory chain complex IV deficiency, appear sufficient to induce pain hypersensitivity, by ADP activation of P2Y1 receptors. Adenosine Diphosphate 173-176 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 191-195 31418386-6 2019 RESULTS: After the ADP activation, the expression level of GPIb significantly decreased, while the expression levels of GPIb, GPIIb/III a and P-selectin significantly increased in control group, nothing bleeding symptom group and mild bleeding symptom group; but the expression level of GPIb significantly increased, while the expression level of GPIIb/III a significantly decreased in moderate and severe bleeding symptom group, the both differences were statistically significant (P<0.05). Adenosine Diphosphate 19-22 selectin P Homo sapiens 142-152 31418386-7 2019 however, the expression level of P-selectin in moderate and severe bleeding symptom groups before and after ADP activation was not statistivally significant (P>0.05). Adenosine Diphosphate 108-111 selectin P Homo sapiens 33-43 31418386-9 2019 After ADP activation, the expression levels of GPIb and P-selectin in ITP subgroups both were lower than those in control group, the expression level of GPIIb/IIIa in ITP subgroups was higher than that in control group (P<0.05). Adenosine Diphosphate 6-9 selectin P Homo sapiens 56-66 31131400-4 2019 A translocation model is proposed for the Upf1-like helicase members according to three different structural conditions in solution characterized through H/D exchange assay, including substrate state (SARS-Nsp13-dsDNA bound with AMPPNP), transition state (bound with ADP-AlF4-) and product state (bound with ADP). Adenosine Diphosphate 267-270 UPF1 RNA helicase and ATPase Homo sapiens 42-46 31131400-4 2019 A translocation model is proposed for the Upf1-like helicase members according to three different structural conditions in solution characterized through H/D exchange assay, including substrate state (SARS-Nsp13-dsDNA bound with AMPPNP), transition state (bound with ADP-AlF4-) and product state (bound with ADP). Adenosine Diphosphate 308-311 UPF1 RNA helicase and ATPase Homo sapiens 42-46 30395215-10 2019 Platelet-derived adenosine diphosphate induced the release of autotaxin (ATX) by VICs. Adenosine Diphosphate 17-38 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 62-71 30395215-10 2019 Platelet-derived adenosine diphosphate induced the release of autotaxin (ATX) by VICs. Adenosine Diphosphate 17-38 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 73-76 30137373-3 2019 Here we demonstrated that P2Y13 and its ligand ADP play an important role in protecting hosts from viral infections. Adenosine Diphosphate 47-50 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 26-31 30137373-4 2019 First, we demonstrate that P2Y13, as a typical interferon-stimulated gene, is induced together with extracellular ADP during viral infection. Adenosine Diphosphate 114-117 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 27-32 30137373-7 2019 Furthermore, cyclic adenosine monophosphate and EPAC1 are downregulated by extracellular ADP through the P2Y13-coupled Gi alpha subunit. Adenosine Diphosphate 89-92 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 105-110 30759486-3 2019 We hypothesized that recovery of ADP-induced platelet activation could be attributed to increased P2Y1 expression induced by chronic aspirin exposure. Adenosine Diphosphate 33-36 purinergic receptor P2Y1 Homo sapiens 98-102 30998678-4 2019 In vitro studies showed that HsRecA L53Q can bind ADP, ATP, and ssDNA, as does wild-type RecA. Adenosine Diphosphate 50-53 recombinase RecA Herbaspirillum seropedicae 31-35 30218597-0 2019 Interplay between reversible phosphorylation and irreversible ADP-ribosylation of eukaryotic translation elongation factor 2. Adenosine Diphosphate 62-65 eukaryotic translation elongation factor 2 Homo sapiens 82-124 31011713-5 2019 Results: For FC, P-selectin exposure and PAC-1 binding was reduced at 10 x 109 L-1 after stimulation with PAR1-AP (by approximately 20% and 50%, respectively), but remained relatively unchanged when ADP was used as agonist (n = 9). Adenosine Diphosphate 199-202 selectin P Homo sapiens 17-27 30867460-2 2019 We solved the structure of ThiL from the human pathogen A. baumanii in complex with a pair of substrates TMP and a non-hydrolyzable adenosine triphosphate analog, and in complex with a pair of products TPP and adenosine diphosphate. Adenosine Diphosphate 210-231 acetyl-CoA acetyltransferase 1 Homo sapiens 27-31 31534882-4 2019 When expressed as a fraction of activated platelets, shape changes were the most sensitive to a low ADP concentration compared to the biochemical markers in the following order of sensitivity: morphological changes>fibrinogen binding capacity>P-selectin expression> phosphatidylserine exposure. Adenosine Diphosphate 100-103 selectin P Homo sapiens 249-259 30654937-1 2019 Human cardiac myosin has two isoforms, alpha and beta, sharing significant sequence similarity, but different in kinetics: ADP release from actomyosin is an order of magnitude faster in the alpha myosin isoform. Adenosine Diphosphate 123-126 myosin heavy chain 14 Homo sapiens 14-20 30792653-5 2019 The flow-cytometry results showed that under 0.1 Pa flow, XST decreased ADP induced platelets CD62p surface expression in a concentration-dependent manner. Adenosine Diphosphate 72-75 selectin P Homo sapiens 94-99 30644400-0 2019 Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2"-PO4 recognition and ADP-ribosylation. Adenosine Diphosphate 95-98 tumor protein, translationally-controlled 1 Homo sapiens 34-38 30644400-5 2019 The structure reveals how Tpt1 recognizes a 2"-PO4 RNA splice junction and the mechanism of RNA phospho-ADP-ribosylation. Adenosine Diphosphate 104-107 tumor protein, translationally-controlled 1 Homo sapiens 26-30 31606080-5 2019 Recently, we developed an integrative proteomic platform for the site-specific analysis of protein ADP-ribosylation on Asp and Glu residues. Adenosine Diphosphate 99-102 assembly factor for spindle microtubules Homo sapiens 119-122 30366102-5 2019 CapNO inhibits both sialyl Lewisx (Slex) expression on HT29 and ADP-induced activation of platelets through P-selectin- and GPIIb/IIIa-dependent mechanisms, confirmed by the corresponding antibody assay. Adenosine Diphosphate 64-67 selectin P Homo sapiens 108-129 30392930-0 2018 Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Adenosine Diphosphate 24-27 phosphoglycerate kinase 1 Homo sapiens 8-12 30473700-3 2018 In this sequence of events, the ectoenzyme CD39 degrades ATP into ADP and AMP, respectively, and CD73 catalyzes the last step leading to the production of Ado. Adenosine Diphosphate 66-69 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 43-47 30357593-5 2018 Once internalised, PE38 catalyses the ADP ribosylation of the diphthamide residue in elongation factor-2 (EF-2), resulting in the rapid fall in levels of the anti-apoptotic protein myeloid cell leukaemia 1 (Mcl-1), leading to apoptotic cell death. Adenosine Diphosphate 38-41 eukaryotic translation elongation factor 2 Homo sapiens 85-104 30300911-6 2018 We also showed for the first time that IL-9 receptor was expressed in mouse platelets, and it dramatically promoted the aggregation rate and expression of P-selectin (CD62P) in the presence of adenosine diphosphate, but otherwise exhibited no effect on platelets. Adenosine Diphosphate 193-214 interleukin 9 receptor Mus musculus 39-52 30349891-8 2018 Adrenaline also increased ADP-induced platelet activation: from 40% (36-54%) to 83% (74-88%) platelets with active fibrinogen receptor (binding PAC-1) and from 13% (7-21%) to 35% (18-50%) P-selectin-expressing platelets. Adenosine Diphosphate 26-29 ADCYAP receptor type I Homo sapiens 144-149 30349891-8 2018 Adrenaline also increased ADP-induced platelet activation: from 40% (36-54%) to 83% (74-88%) platelets with active fibrinogen receptor (binding PAC-1) and from 13% (7-21%) to 35% (18-50%) P-selectin-expressing platelets. Adenosine Diphosphate 26-29 selectin P Homo sapiens 188-198 30006350-10 2018 One of these proteins, ADP/ATP translocase 2 (ANT2), known to be involved in mitotic spindle formation, colocalized with miR-29b in perinuclear clusters independently of Argonaute 2. Adenosine Diphosphate 23-26 solute carrier family 25 member 6 Homo sapiens 46-50 30031975-5 2018 Here we report the structure determination of two crystal forms of the ternary Eg5-ADP-K858 complex, locking the motor in the so-called final inhibitor bound state, thus blocking ADP release, a crucial stage for Eg5 activity. Adenosine Diphosphate 83-86 kinesin family member 11 Homo sapiens 79-82 30031975-5 2018 Here we report the structure determination of two crystal forms of the ternary Eg5-ADP-K858 complex, locking the motor in the so-called final inhibitor bound state, thus blocking ADP release, a crucial stage for Eg5 activity. Adenosine Diphosphate 83-86 kinesin family member 11 Homo sapiens 212-215 30382520-3 2018 The data are consistent with a mechanochemical model in which a decrease in pH reduces myosin"s detachment from actin (by slowing ADP release), increases non-productive myosin binding (by detached myosin rebinding without a powerstroke), and reduces myosin"s attachment to actin (by slowing the weak-to-strong binding transition). Adenosine Diphosphate 130-133 myosin heavy chain 14 Homo sapiens 87-93 29782832-4 2018 In this study, we test the hypothesis that Nup159 controls the ADP-bound state of Dbp5. Adenosine Diphosphate 63-66 DEAD-box helicase 19B Homo sapiens 82-86 30423175-8 2018 The mutation resulted in decreased PRPS1 inhibition by ADP. Adenosine Diphosphate 55-58 phosphoribosyl pyrophosphate synthetase 1 Homo sapiens 35-40 29653079-1 2018 The adenine nucleotide translocase (ANT) of the mitochondrial inner membrane exchanges ADP for ATP. Adenosine Diphosphate 87-90 solute carrier family 25 member 6 Homo sapiens 4-34 29653079-1 2018 The adenine nucleotide translocase (ANT) of the mitochondrial inner membrane exchanges ADP for ATP. Adenosine Diphosphate 87-90 solute carrier family 25 member 6 Homo sapiens 36-39 29653079-3 2018 Carboxyatractyloside titration of O2 consumption rate (Jo) at clamped [ADP] of 21 muM gave ANT abundance of 0.97 +- 0.14 nmol ANT/mg and a flux control coefficient of 82% +- 6%. Adenosine Diphosphate 71-74 solute carrier family 25 member 6 Homo sapiens 91-94 29653079-12 2018 As predicted by molecular dynamic modeling, ANT Lysine23 acetylation decreased the apparent affinity of ADP for ANT binding. Adenosine Diphosphate 104-107 solute carrier family 25 member 6 Homo sapiens 44-47 29653079-12 2018 As predicted by molecular dynamic modeling, ANT Lysine23 acetylation decreased the apparent affinity of ADP for ANT binding. Adenosine Diphosphate 104-107 solute carrier family 25 member 6 Homo sapiens 112-115 29436006-2 2018 Both ATP/adenosine diphosphate (ADP) and adenosine modulate ACh secretion by activating presynaptic P2Y13 and A1 , A2A , and A3 receptors, respectively. Adenosine Diphosphate 32-35 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 100-105 29436006-6 2018 At 15 and 20 mM K+ , endogenous ATP/ADP and adenosine bind to inhibitory P2Y13 and A1 and A3 receptors since AR-C69931MX, DPCPX, and MRS-1191 increased MEPP frequency. Adenosine Diphosphate 36-39 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 73-78 29332180-2 2018 Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5"-nucleotidase. Adenosine Diphosphate 48-51 5' nucleotidase, ecto Mus musculus 161-165 29453282-9 2018 Of note, ADP-ribosylation of eEF2 domain IV blocked reverse translocation, suggesting a crucial role of interactions of this domain with the ribosome for the catalysis of the reaction. Adenosine Diphosphate 9-12 eukaryotic translation elongation factor 2 Homo sapiens 29-33 29235081-2 2018 The cytoskeletal motor proteins myosin and kinesin are structurally similar in the core architecture of their motor domains and have similar force-producing mechanisms that are coupled with the chemical cycles of ATP binding, hydrolysis, Pi release and subsequent ADP release. Adenosine Diphosphate 264-267 myosin heavy chain 14 Homo sapiens 32-38 29361132-0 2018 Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase family member 3 Homo sapiens 71-76 29361132-7 2018 Finally, we show an effective PARP3- or PARP2-catalyzed ADP-ribosylation of high-molecular-weight (~3-kb) DNA molecules, PARP-mediated DNA PARylation in cell-free extracts and a persisting signal of anti-PAR antibodies in a serially purified genomic DNA from bleomycin-treated poly(ADP-ribose) glycohydrolase-depleted HeLa cells. Adenosine Diphosphate 56-59 poly(ADP-ribose) polymerase family member 3 Homo sapiens 30-35 28777435-4 2018 The nucleotide potency profile and the blockade of the ADP-mediated inhibitory effect by the phospholipase C inhibitor U-73122 suggest that P2Y1 receptor controls ZL55 cell proliferation. Adenosine Diphosphate 55-58 purinergic receptor P2Y1 Homo sapiens 140-153 28777435-5 2018 The activation of P2Y1 receptor by ADP leads to activation of intracellular transduction pathways involving [Ca2+ ]i , PKC-delta/PKC-alpha, and MAPKs, ERK1/2 and JNK1/2. Adenosine Diphosphate 35-38 purinergic receptor P2Y1 Homo sapiens 18-31 28777435-7 2018 Inhibition of ZL55 cell proliferation by ADP was completely reversed by inhibiting MEK1/2, or JNK1/2, or PKC-delta, and PKC-alpha. Adenosine Diphosphate 41-44 mitogen-activated protein kinase kinase 1 Homo sapiens 83-89 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 97-105 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 106-110 34402252-10 2021 ATP level in the SIK2 overexpression group was higher than that in the reperfusion group and adenovirus no-load group (all <0.05), and ADP was decreased in the SIK2 overexpression group (all <0.05). Adenosine Diphosphate 135-138 salt-inducible kinase 2 Rattus norvegicus 160-164 34402252-11 2021 SIK2 can up-regulate the ATP level and down-regulate the ADP level in rat brain tissue and alleviate cerebral ischemia-reperfusion injury by increase the level of HIF-1alpha. Adenosine Diphosphate 57-60 salt-inducible kinase 2 Rattus norvegicus 0-4 35622909-1 2022 The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Mac1) removes adenosine diphosphate (ADP) ribosylation posttranslational modifications, playing a key role in the immune evasion capabilities of the virus responsible for the coronavirus disease 2019 pandemic. Adenosine Diphosphate 149-152 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 29-33 29387685-5 2017 CD spectroscopy was successfully used to determine the stoichiometry of a ternary protein complex among Hsp90, Sgt1, and Rar1 in the presence of excess ADP. Adenosine Diphosphate 152-155 heat shock protein 90 alpha family class A member 1 Homo sapiens 104-109 29375385-4 2017 First, an in vitro study showed that pretreatment of murine splenic T cells with 100-250 muM ATP, ADP, or AMP significantly suppressed the concanavalin A (ConA)-induced release of cytokines, including IL-2. Adenosine Diphosphate 98-101 interleukin 2 Mus musculus 201-205 35622909-2 2022 Here, we determined neutron and x-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain using multiple crystal forms, temperatures, and pHs, across the apo and ADP-ribose-bound states. Adenosine Diphosphate 164-167 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 75-79 29171876-8 2018 In group 2, significantly higher platelet surface expression of P-selectin was seen in anaemia after stimulation with ADP (P = .02). Adenosine Diphosphate 118-121 selectin P Homo sapiens 64-74 35283778-13 2022 The upregulation and increased activity of purinergic receptors activated by ADP/ATP, specially P2X4R, which has a high permeability to calcium and is mainly expressed in microglial cells, is observed in diseases related to neuroinflammation, such as neuropathic pain and stroke. Adenosine Diphosphate 77-80 purinergic receptor P2X 4 Homo sapiens 96-101 28300459-4 2017 Activation-dependent platelet surface marker expression of PAC-1 (binds to GPIIb/IIIa surface receptors on activated platelets) and CD62P (marker for P-selectin released from activated degranulated platelets) was assessed in adenosine diphosphate (ADP)-stimulated platelets using flow cytometry. Adenosine Diphosphate 225-246 selectin P Homo sapiens 132-137 28300459-4 2017 Activation-dependent platelet surface marker expression of PAC-1 (binds to GPIIb/IIIa surface receptors on activated platelets) and CD62P (marker for P-selectin released from activated degranulated platelets) was assessed in adenosine diphosphate (ADP)-stimulated platelets using flow cytometry. Adenosine Diphosphate 225-246 selectin P Homo sapiens 150-160 29209319-1 2017 The ectoenzymes CD39 and CD73 regulate the purinergic signaling through the hydrolysis of adenosine triphosphate (ATP)/ADP to AMP and to adenosine (Ado), respectively. Adenosine Diphosphate 119-122 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 16-20 28928091-2 2017 To this end, adenosine diphosphate (ADP) is an important platelet activator that acts by binding to the G-protein coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 13-34 purinergic receptor P2Y1 Homo sapiens 122-126 28928091-2 2017 To this end, adenosine diphosphate (ADP) is an important platelet activator that acts by binding to the G-protein coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 36-39 purinergic receptor P2Y1 Homo sapiens 122-126 35183932-5 2022 SsnB also inhibited U46619-induced and ADP-induced phosphorylation of phospholipase C (PLC)gamma2/protein kinase C (PKC) and intracellular calcium mobilization, both of which are required for platelet aggregation. Adenosine Diphosphate 39-42 phospholipase C gamma 2 Homo sapiens 70-97 35127709-5 2021 We show that intra-peroxisomal ATP levels are maintained by different peroxisomal membrane proteins each with different modes of action: 1) the previously reported Ant1p protein, which catalyzes the exchange of ATP for AMP or ADP, 2) the ABC transporter protein complex Pxa1p/Pxa2p, which mediates both uni-directional acyl-CoA and ATP uptake, and 3) the mitochondrial Aac2p protein, which catalyzes ATP/ADP exchange and has a dual localization in both mitochondria and peroxisomes. Adenosine Diphosphate 226-229 Ant1p Saccharomyces cerevisiae S288C 164-169 28808052-7 2017 Mavacamten also decreased the rate of myosin binding to actin in the ADP-bound state and the ADP-release rate from myosin-S1 alone. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 38-44 28808052-7 2017 Mavacamten also decreased the rate of myosin binding to actin in the ADP-bound state and the ADP-release rate from myosin-S1 alone. Adenosine Diphosphate 93-96 myosin heavy chain 14 Homo sapiens 115-121 35127709-5 2021 We show that intra-peroxisomal ATP levels are maintained by different peroxisomal membrane proteins each with different modes of action: 1) the previously reported Ant1p protein, which catalyzes the exchange of ATP for AMP or ADP, 2) the ABC transporter protein complex Pxa1p/Pxa2p, which mediates both uni-directional acyl-CoA and ATP uptake, and 3) the mitochondrial Aac2p protein, which catalyzes ATP/ADP exchange and has a dual localization in both mitochondria and peroxisomes. Adenosine Diphosphate 404-407 Ant1p Saccharomyces cerevisiae S288C 164-169 28962125-4 2017 The basal and ADP-induced CD62P expression rates of platelets were assessed by flow cytometry to evaluate the function of platelets in PCP and P-PRP. Adenosine Diphosphate 14-17 selectin P Homo sapiens 26-31 28033029-3 2017 Patients with Gram-positive sepsis had the highest median fluorescence intensity (MFI) of the platelet membrane expression of P-selectin upon stimulation with high dose adenosine diphosphate (ADP; P = 0.002 vs. Gram-negative and P = 0.005 vs. control groups) and cross-linked collagen-related peptide (CRP-XL; P = 0.02 vs. Gram-negative and P = 0.0001 vs. control groups). Adenosine Diphosphate 169-190 selectin P Homo sapiens 126-136 28033029-3 2017 Patients with Gram-positive sepsis had the highest median fluorescence intensity (MFI) of the platelet membrane expression of P-selectin upon stimulation with high dose adenosine diphosphate (ADP; P = 0.002 vs. Gram-negative and P = 0.005 vs. control groups) and cross-linked collagen-related peptide (CRP-XL; P = 0.02 vs. Gram-negative and P = 0.0001 vs. control groups). Adenosine Diphosphate 192-195 selectin P Homo sapiens 126-136 2783136-3 1989 In agreement with earlier views on the aggregation-dependency of weak agonist-induced thromboxane synthesis and 5-hydroxytryptamine (5HT) secretion, RGDS (100-300 microM) inhibited these events induced by ADP, adrenaline and low concentrations of thrombin and collagen but not that induced by high concentrations of thrombin and collagen. Adenosine Diphosphate 205-208 ral guanine nucleotide dissociation stimulator Homo sapiens 149-153 2527238-4 1989 Antibodies raised against a synthetic peptide WTVPTA (Trp-Thr-Val-Pro-Thr-Ala) deduced from the cloned rat FN RGDS domain block ADP-mediated platelet aggregation; this block can be overcome by additional fibrinogen. Adenosine Diphosphate 128-131 ral guanine nucleotide dissociation stimulator Homo sapiens 110-114 2752142-2 1989 Moreover, the murine monoclonal antibody (MoAb) PG-1, which recognizes GPIb in guinea pig platelets and megakaryocytes, exerted full inhibition on von Willebrand factor (vWF)-dependent platelet agglutination without inhibiting aggregation induced by ADP, collagen, or thrombin. Adenosine Diphosphate 250-253 von Willebrand factor Cavia porcellus 147-168 2752142-2 1989 Moreover, the murine monoclonal antibody (MoAb) PG-1, which recognizes GPIb in guinea pig platelets and megakaryocytes, exerted full inhibition on von Willebrand factor (vWF)-dependent platelet agglutination without inhibiting aggregation induced by ADP, collagen, or thrombin. Adenosine Diphosphate 250-253 von Willebrand factor Cavia porcellus 170-173 2917173-0 1989 Relationships between chemical structure and inhibition of ADP-stimulated human thrombocyte release of serotonin and platelet factor 4. Adenosine Diphosphate 59-62 platelet factor 4 Homo sapiens 117-134 2905773-5 1988 Studies on IAP catalyzed 32P-ADP-ribosylation of astroglial cell particulate material revealed an incorporation of radiolabel into three polypeptides in the molecular weight range of 41,000-39,000 Dalton. Adenosine Diphosphate 29-32 Cd47 molecule Rattus norvegicus 11-14 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 123-126 PEAK1 related, kinase-activating pseudokinase 1 Homo sapiens 62-68 2843248-3 1988 Using washed human platelets, we confirmed that the number of peak 2 Fgn molecules binding to platelets in the presence of ADP was about half the number of peak 1 Fgn molecules (18,962 +/- 2,298 v 44,366 +/- 16,096 molecules per platelet), and that isolated S-carboxymethylated (SCM) gammaA chains supported ADP-induced platelet aggregation nearly as well as peak 1 Fgn. Adenosine Diphosphate 308-311 PEAK1 related, kinase-activating pseudokinase 1 Homo sapiens 62-68 2850287-4 1988 The reaction was specific for 5"-nucleotidase because it was inhibited by ADP. Adenosine Diphosphate 74-77 5' nucleotidase, ecto Rattus norvegicus 30-45 3343240-3 1988 The binding site is located at the analogous position of the ADP moiety of FAD in glutathione reductase, the FAD and NADPH binding domains of which resemble two of the domains of trimethylamine dehydrogenase. Adenosine Diphosphate 61-64 glutathione-disulfide reductase Homo sapiens 82-103 2962998-7 1988 Transient kinetic experiments showed that Mg2+ competitively inhibited (Ki = 0.7 mM) binding of Ca2+ to lumenal transport sites, blocking the ability of Ca2+ to reverse the catalytic cycle to form ADP-sensitive, from ADP-insensitive, phosphoenzyme. Adenosine Diphosphate 197-200 mucin 7, secreted Homo sapiens 42-45 2962998-7 1988 Transient kinetic experiments showed that Mg2+ competitively inhibited (Ki = 0.7 mM) binding of Ca2+ to lumenal transport sites, blocking the ability of Ca2+ to reverse the catalytic cycle to form ADP-sensitive, from ADP-insensitive, phosphoenzyme. Adenosine Diphosphate 217-220 mucin 7, secreted Homo sapiens 42-45 3334894-2 1988 Because with human platelets the cell adhesion peptide, Arg-Gly-Asp-Ser (RGDS), inhibits aggregation and the binding of 125I-fibrinogen to ADP-stimulated platelets, its effects on rabbit and rat platelets were studied to investigate the differences in the fibrinogen requirements of platelets from the three species. Adenosine Diphosphate 139-142 ral guanine nucleotide dissociation stimulator Homo sapiens 73-77 3334894-4 1988 RGDS inhibited the binding of 125I-fibrinogen to ADP-stimulated human platelets by 80% to 90%, but by only 15% to 27% in the case of rabbit or rat platelets. Adenosine Diphosphate 49-52 ral guanine nucleotide dissociation stimulator Homo sapiens 0-4 2889730-4 1987 In the presence of ADP, the saturation curve of ATP changed from hyperbolic to a sigmoid shape, suggesting that the proton ATPase is an allosteric enzyme. Adenosine Diphosphate 19-22 dynein axonemal heavy chain 8 Homo sapiens 123-129 2822043-1 1987 The effect of intraliposomal ADP and ATP on the kinetics of cytochrome c oxidation in reconstituted bovine heart cytochrome c oxidase was measured by the photometric and polarographic method: 1. Adenosine Diphosphate 29-32 LOC104968582 Bos taurus 60-72 2822043-1 1987 The effect of intraliposomal ADP and ATP on the kinetics of cytochrome c oxidation in reconstituted bovine heart cytochrome c oxidase was measured by the photometric and polarographic method: 1. Adenosine Diphosphate 29-32 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 113-133 2822043-8 1987 Under coupled conditions only a small decrease of the Km for cytochrome c by intraliposomal ADP is found. Adenosine Diphosphate 92-95 LOC104968582 Bos taurus 61-73 3686483-1 1987 The ability of three naturally occurring human fibrinogen species, HMW, LMW and LMW", to support ADP-induced platelet aggregation was investigated and compared to their ability to bind to gel-filtered platelets. Adenosine Diphosphate 97-100 cilia and flagella associated protein 97 Homo sapiens 67-70 2825631-3 1987 Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl4 to a free-radical species identified as trichloromethyl free radical (CCl3) by e.s.r. Adenosine Diphosphate 86-89 C-C motif chemokine ligand 3 Rattus norvegicus 193-197 2960520-6 1987 Water-soluble porin competed for the specific binding and import of the precursor of the ADP/ATP carrier, an inner membrane protein. Adenosine Diphosphate 89-92 voltage dependent anion channel 1 Homo sapiens 14-19 28744459-0 2017 Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease. Adenosine Diphosphate 70-73 lon peptidase 1, mitochondrial Homo sapiens 91-103 28744459-5 2017 Due to the low affinity of human Lon for ADP, the conformational changes in human Lon generated from the ATPase cycle are also different. Adenosine Diphosphate 41-44 lon peptidase 1, mitochondrial Homo sapiens 33-36 28744459-5 2017 Due to the low affinity of human Lon for ADP, the conformational changes in human Lon generated from the ATPase cycle are also different. Adenosine Diphosphate 41-44 lon peptidase 1, mitochondrial Homo sapiens 82-85 28744459-6 2017 The relatively low affinity of human Lon for ADP cannot be accounted for by reversibility in ATP hydrolysis, as a positional isotope exchange experiment demonstrated both E. coli Lon and human Lon catalyzed ATP hydrolysis irreversibly. Adenosine Diphosphate 45-48 lon peptidase 1, mitochondrial Homo sapiens 37-40 28744459-6 2017 The relatively low affinity of human Lon for ADP cannot be accounted for by reversibility in ATP hydrolysis, as a positional isotope exchange experiment demonstrated both E. coli Lon and human Lon catalyzed ATP hydrolysis irreversibly. Adenosine Diphosphate 45-48 lon peptidase 1, mitochondrial Homo sapiens 179-182 28300864-7 2017 Using gene-based association tests of rare and low-frequency variants, we found significant associations of HYAL2 with increased ADP-induced aggregation (p = 1.07x10-7) and GSTZ1 with increased epinephrine-induced aggregation (p = 1.62x10-6). Adenosine Diphosphate 129-132 hyaluronidase 2 Homo sapiens 108-113 27755650-3 2017 Ventricular myofibroblasts also express ADP-sensitive P2Y1 , P2Y12 , and P2Y13 receptors as demonstrated by immunofluorescence confocal microscopy and western blot analysis, but little information exists on ADP effects in these cells. Adenosine Diphosphate 40-43 purinergic receptor P2Y12 Rattus norvegicus 61-66 3611103-2 1987 5-Oxoprolinase catalyzes a reaction in which the cleavage of ATP to ADP and Pi and the decyclization of 5-oxoproline to form glutamate are coupled. Adenosine Diphosphate 68-71 5-oxoprolinase (ATP-hydrolysing) Rattus norvegicus 0-14 28404750-1 2017 Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the mitochondrial inner membrane, an activity that is essential for oxidative phosphorylation (OXPHOS). Adenosine Diphosphate 68-71 solute carrier family 25 member 6 Homo sapiens 15-45 28404750-1 2017 Members of the adenine nucleotide translocase (ANT) family exchange ADP for ATP across the mitochondrial inner membrane, an activity that is essential for oxidative phosphorylation (OXPHOS). Adenosine Diphosphate 68-71 solute carrier family 25 member 6 Homo sapiens 47-50 28404750-9 2017 In contrast, pharmacological inhibition of OXPHOS expression and function inhibits ANT-dependent ADP/ATP exchange. Adenosine Diphosphate 97-100 solute carrier family 25 member 6 Homo sapiens 83-86 2889467-0 1987 ADP, chloride ion, and metal ion binding to bovine brain glutamine synthetase. Adenosine Diphosphate 0-3 glutamate-ammonia ligase Bos taurus 57-77 27554816-11 2017 In mouse studies, P2ry13 and P2ry14-purinergic receptors activated by adenosine 5-diphosphate and UDP-sugars, respectively-were upregulated after allergen challenge, notably in airway epithelial cells, eosinophils, and neutrophils. Adenosine Diphosphate 70-93 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 18-24 3446174-11 1987 Mg2+ also appears to interact with the sites, but this is largely abolished by ATP and ADP (but not AMP) under conditions in which the free [Mg2+] is maintained constant. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 0-3 28144998-6 2017 In this study, we found that CC chemokine ligand 3 (CCL3) is induced by ADP-treated primary microglia. Adenosine Diphosphate 72-75 C-C motif chemokine ligand 3 Homo sapiens 29-50 28144998-6 2017 In this study, we found that CC chemokine ligand 3 (CCL3) is induced by ADP-treated primary microglia. Adenosine Diphosphate 72-75 C-C motif chemokine ligand 3 Homo sapiens 52-56 3446174-11 1987 Mg2+ also appears to interact with the sites, but this is largely abolished by ATP and ADP (but not AMP) under conditions in which the free [Mg2+] is maintained constant. Adenosine Diphosphate 87-90 mucin 7, secreted Homo sapiens 141-144 3593706-9 1987 However, DPL nonpolymerized vesicles, while not causing aggregation, did impair ADP-induced aggregation of platelets. Adenosine Diphosphate 80-83 prion like protein doppel Homo sapiens 9-12 28167530-2 2017 Rcf1 interacts with components of the mitochondrial oxidative phosphorylation system, in particular the cytochrome bc1 (complex III)-cytochrome c oxidase (complex IV) supercomplex (termed III-IV) and the ADP/ATP carrier proteins. Adenosine Diphosphate 204-207 Rcf1p Saccharomyces cerevisiae S288C 0-4 27510652-2 2016 Adenosine diphosphate (ADP)-ribosylation is a post-translational modification reaction that catalyzes the transfer of ADP-ribose group to eEF2 and this causes the inhibition of protein synthesis. Adenosine Diphosphate 0-21 eukaryotic translation elongation factor 2 Homo sapiens 138-142 27510652-2 2016 Adenosine diphosphate (ADP)-ribosylation is a post-translational modification reaction that catalyzes the transfer of ADP-ribose group to eEF2 and this causes the inhibition of protein synthesis. Adenosine Diphosphate 23-26 eukaryotic translation elongation factor 2 Homo sapiens 138-142 2957817-0 1987 Kinetics of the beta-thromboglobulin release from alpha-granules of blood platelets activated by ADP. Adenosine Diphosphate 97-100 pro-platelet basic protein Homo sapiens 16-36 27510652-2 2016 Adenosine diphosphate (ADP)-ribosylation is a post-translational modification reaction that catalyzes the transfer of ADP-ribose group to eEF2 and this causes the inhibition of protein synthesis. Adenosine Diphosphate 118-121 eukaryotic translation elongation factor 2 Homo sapiens 138-142 27906627-2 2016 Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5"-nucleotidase (CD73) convert extracellular nucleotides in a sequential order: ATP to ADP, AMP, and then to adenosine. Adenosine Diphosphate 152-155 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-48 27906627-2 2016 Ectonucleoside triphosphate diphosphohydrolase 1 (CD39) and ecto-5"-nucleotidase (CD73) convert extracellular nucleotides in a sequential order: ATP to ADP, AMP, and then to adenosine. Adenosine Diphosphate 152-155 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 50-54 2957817-1 1987 Mathematical model of the beta-thromboglobulin (BTG) release from alpha-granules stimulated with ADP is compared with experimental data. Adenosine Diphosphate 97-100 pro-platelet basic protein Homo sapiens 26-46 2957817-1 1987 Mathematical model of the beta-thromboglobulin (BTG) release from alpha-granules stimulated with ADP is compared with experimental data. Adenosine Diphosphate 97-100 pro-platelet basic protein Homo sapiens 48-51 2957817-3 1987 The release of BTG was monitored in response to 5-100 microM ADP. Adenosine Diphosphate 61-64 pro-platelet basic protein Homo sapiens 15-18 2957817-4 1987 The rate constant of the release of BTG (K = 1.83 X 10(3) M-1 min-1) and efficient amount of ADP molecules secreted by a single platelet (W = 5.2 X 10(-18) mole) were estimated. Adenosine Diphosphate 93-96 pro-platelet basic protein Homo sapiens 36-39 3103619-4 1987 Incubation of mitochondria with 0.05 mM of MPP+ together with glutamate, malate and ADP resulted in approximately 50% inhibition of NADH-ubiquinone oxidoreductase activity. Adenosine Diphosphate 84-87 NADH:ubiquinone oxidoreductase subunit S6 Rattus norvegicus 132-162 26674810-12 2016 However, the impairment of P2X1 and especially of P2Y1 receptor function indicated by decreased receptor-mediated calcium flux is an important mechanism contributing to reduced ADP responsiveness of stored platelets. Adenosine Diphosphate 177-180 purinergic receptor P2X 1 Homo sapiens 27-31 27065056-3 2016 For this reason P2Y12-receptor specific assays have been developed by adding prostaglandin E1 (PGE1) to reduce ADP-induced platelet activation via the P2Y1-receptor. Adenosine Diphosphate 111-114 purinergic receptor P2Y1 Homo sapiens 151-164 3005832-9 1986 These results indicate that NEM uncoupled GTP-binding proteins from receptors by modifying alpha-subunits of GTP-binding proteins, and the site seemed to be on or near the site of ADP-ribosylation by IAP. Adenosine Diphosphate 180-183 CD47 molecule Bos taurus 200-203 27782859-6 2016 RESULTS: We detected that CeCa-MSCs express higher levels of CD39 and CD73 ectonucleotidases in cell membranes compared to NCx-MSCs, and that this feature was associated with the ability to strongly suppress the proliferation, activation and effector functions of cytotoxic T-cells through the generation of large amounts of Ado from the hydrolysis of ATP, ADP and AMP nucleotides. Adenosine Diphosphate 357-360 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 61-65 27721487-8 2016 We propose that the structural rearrangement of the ATP binding site is crucial for the release of ADP, enabling the fast turnover of DDX41 for the dsDNA/CDN-induced STING activation pathway. Adenosine Diphosphate 99-102 DEAD-box helicase 41 Homo sapiens 134-139 3877724-7 1985 Actin increases the rate of epsilon-aza-ADP dissociation from bovine cardiac myosin-S1 from 1.9 to 110 s-1 at 15 degrees C which can be compared to 0.3 and 65 s-1 for ADP dissociation under similar conditions. Adenosine Diphosphate 40-43 actin epsilon 1 Bos taurus 0-5 27854030-5 2016 By eliminating extra-mitochondrial ADP with an excess of pyruvate kinase and its substrate phosphoenolpyruvate, the coupling of the AK reaction with mitochondrial ATP synthesis could be quantified for total AK and mitochondrial AK2 as a specific AK index. Adenosine Diphosphate 35-38 adenylate kinase 2 Mus musculus 228-231 3904480-11 1985 In addition, insulin injection prevented, whereas glucagon enhanced, the normal postnatal increase in tissue ATP/ADP. Adenosine Diphosphate 113-116 insulin Oryctolagus cuniculus 13-20 27206526-6 2016 Consistent with involvement of P2X7, a high ATP concentration (1 mM) potentiated Wnt3a-induced beta-catenin transcriptional activity, whereas a low concentration (10 muM) of ATP, adenosine 5"-diphosphate (ADP), or uridine 5"-triphosphate (UTP) failed to elicit a response. Adenosine Diphosphate 205-208 wingless-type MMTV integration site family, member 3A Mus musculus 81-86 2417354-4 1985 A strong positive correlation was observed between the levels of plasma beta TG and PF4 and between platelet aggregation to ADP and that to epinephrine in both the hypertensive and normotensive groups. Adenosine Diphosphate 124-127 pro-platelet basic protein Homo sapiens 72-79 27210814-2 2016 CD39 is an ectonucleotidase that catalyzes extracellular ATP/ADP hydrolysis, culminating in the generation of immunosuppressive adenosine. Adenosine Diphosphate 61-64 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 2932113-7 1985 Substrate MgATP2- or MgADP enhanced the inactivation of gizzard myosin; there was an increase in the incorporation of the reagent and a change in the distribution into the heavy chains. Adenosine Diphosphate 21-26 myosin, heavy chain 15 Gallus gallus 64-70 27131790-2 2016 Our published work has demonstrated a dual function of the SWI5-SFR1 complex in RAD51-mediated DNA strand exchange, namely, by stabilizing the presynaptic filament and maintaining the catalytically active ATP-bound state of the filament via enhancement of ADP release. Adenosine Diphosphate 256-259 SWI5 dependent homologous recombination repair protein 1 Homo sapiens 64-68 6391482-3 1984 Deenergizing treatments, such as ADP plus Pi, result in the conversion of all the mitochondrial cytochrome b-564 into its low-potential form, whereas energization with ATP specifically transforms the cytochrome into its high-potential form, the ATP effect being neutralized by the ATPase inhibitor oligomycin and by the uncoupler FCCP. Adenosine Diphosphate 33-36 cytochrome b Saccharomyces cerevisiae S288C 96-108 27475285-4 2016 However, it is not known whether other pathways of platelet activation, such as adenosine diphosphate (ADP)-mediated receptor P2Y12 activation is also protective. Adenosine Diphosphate 80-101 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 126-131 27475285-4 2016 However, it is not known whether other pathways of platelet activation, such as adenosine diphosphate (ADP)-mediated receptor P2Y12 activation is also protective. Adenosine Diphosphate 103-106 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 126-131 6725273-8 1984 More than half of the nuclear mono- and poly(ADP-ribosyl) residues were linked to histone H2B. Adenosine Diphosphate 45-48 H2B clustered histone 12 Rattus norvegicus 82-93 26578648-8 2016 Platelet-neutrophil complex formation depends on platelet P-selectin expression, and antibody blocking of P-selectin consequently prevented ADP-induced platelet-neutrophil complex formation. Adenosine Diphosphate 140-143 selectin P Homo sapiens 58-68 26578648-8 2016 Platelet-neutrophil complex formation depends on platelet P-selectin expression, and antibody blocking of P-selectin consequently prevented ADP-induced platelet-neutrophil complex formation. Adenosine Diphosphate 140-143 selectin P Homo sapiens 106-116 6428400-2 1984 When platelets were activated with ADP or 5-hydroxytryptamine, actin was polymerized quickly followed by rapid depolymerization to the initial level. Adenosine Diphosphate 35-38 actin epsilon 1 Bos taurus 63-68 26895088-7 2016 Mean fluorescence intensity and percent positivity of CD62 on ADP-activated platelets were evaluated using flow cytometry. Adenosine Diphosphate 62-65 selectin P Homo sapiens 54-58 26895088-9 2016 RESULTS: Compared with healthy controls, trauma patients had significantly decreased ADP- and TRAP-mediated platelet aggregation and ADP-mediated CD62 expression. Adenosine Diphosphate 133-136 selectin P Homo sapiens 146-150 6232149-1 1984 Beef heart mitochondrial F1-ATPase was inactivated by the 2",3"-dialdehyde derivatives of ATP, ADP and AMP (oATP, oADP, oAMP). Adenosine Diphosphate 95-98 solute carrier organic anion transporter family member 1A2 Homo sapiens 108-112 26519900-4 2016 One important example is the ADP-induced platelet aggregation mediated by P2Y1 and P2Y12 receptors. Adenosine Diphosphate 29-32 purinergic receptor P2Y1 Homo sapiens 74-78 6137181-1 1983 gamma-Glutamylcysteine synthetase catalyses the combination of L-glutamate and L-cysteine to form gamma-glutamylcysteine with a stoichiometric conversion of ATP to ADP and inorganic phosphate (Pi). Adenosine Diphosphate 164-167 glutamate-cysteine ligase catalytic subunit Homo sapiens 0-33 26935249-8 2016 After transfusion, maximal agonist-induced PLT P-selectin expression was on average 29% higher for ADP (p = 0.02), 25% higher for TRAP (p = 0.007), and 24% higher for CVX (p = 0.0008). Adenosine Diphosphate 99-102 selectin P Homo sapiens 47-57 26519038-2 2016 Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among others. Adenosine Diphosphate 154-157 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens 222-228 6133856-6 1983 This mechanism is based on a rapid shuttling of the ATPase molecules between an ADP-sensitive and an ADP-insensitive phosphorylated state. Adenosine Diphosphate 80-83 dynein axonemal heavy chain 8 Homo sapiens 52-58 26542978-6 2016 With gamma1 complexes, activation and Thr(172) phosphorylation induced by the upstream kinase LKB1 [liver kinase B1; but not calmodulin-dependent kinase kinase (CaMKKbeta)] in cell-free assays was markedly promoted by AMP and, to a smaller extent and less potently, by ADP. Adenosine Diphosphate 269-272 serine/threonine kinase 11 Homo sapiens 94-98 26542978-6 2016 With gamma1 complexes, activation and Thr(172) phosphorylation induced by the upstream kinase LKB1 [liver kinase B1; but not calmodulin-dependent kinase kinase (CaMKKbeta)] in cell-free assays was markedly promoted by AMP and, to a smaller extent and less potently, by ADP. Adenosine Diphosphate 269-272 serine/threonine kinase 11 Homo sapiens 100-115 6133856-6 1983 This mechanism is based on a rapid shuttling of the ATPase molecules between an ADP-sensitive and an ADP-insensitive phosphorylated state. Adenosine Diphosphate 101-104 dynein axonemal heavy chain 8 Homo sapiens 52-58 6687224-2 1983 The native IAP was without effect, but its A-protomer, an active subunit, was effective after reduction of disulfide bonds in the peptide chain; it catalyzed ADP-ribosylation of the membrane Mr = 41,000 protein. Adenosine Diphosphate 158-161 Cd47 molecule Rattus norvegicus 11-14 27635149-1 2016 P2Y1 receptor (P2Y1R), which belongs to G protein-coupled receptors (GPCRs), is an important target in ADP-induced platelet aggregation. Adenosine Diphosphate 103-106 purinergic receptor P2Y1 Homo sapiens 0-13 27635149-1 2016 P2Y1 receptor (P2Y1R), which belongs to G protein-coupled receptors (GPCRs), is an important target in ADP-induced platelet aggregation. Adenosine Diphosphate 103-106 purinergic receptor P2Y1 Homo sapiens 15-20 26328528-7 2016 Two unique components are genetically combined in this molecule: 1) The ecto-nucleoside triphosphate diphosphohydrolase NTPDase CD39, which enzymatically degrades ATP and ADP to AMP, which is then further degraded to adenosine by the endothelially expressed CD73. Adenosine Diphosphate 171-174 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 128-132 26662566-3 2016 The expression of P2Y1 receptor, the major signal transduction machinery for adenosine triphosphate/adenosine diphosphate, decreased in hepatic vascular endothelial cells over time. Adenosine Diphosphate 100-121 purinergic receptor P2Y1 Homo sapiens 18-31 25970449-9 2016 Furthermore, we suggest that secondary release of ADP and concomitant signaling via PAR1/4- and P2Y12 receptors is important for efficient platelet lysosomal exocytosis by thrombin. Adenosine Diphosphate 50-53 Prader Willi/Angelman region RNA 1 Homo sapiens 84-88 26621701-3 2015 We investigated whether ADP-stimulated force development (without Ca(2+)) can be used to reveal changes in actin-myosin blockade in human cardiomyopathy cardiomyocytes. Adenosine Diphosphate 24-27 myosin heavy chain 14 Homo sapiens 113-119 6215739-5 1982 Mean beta TG and the mean beta TG: whole blood platelet count ratio were higher in the increased and decreased responders to ADP than in the normal aggregation group, but the differences in means were not statistically significant. Adenosine Diphosphate 125-128 pro-platelet basic protein Homo sapiens 5-12 26395809-4 2015 Cardiac-specific genes showed enhanced expression of alpha-MHC, MLC2v, alpha-actinin, connexin 45 (Cx45), and HCN4, on both gene and protein levels upon ADP/ATP treatment, indicating increased cardiomyogenesis and pacemaker cell differentiation. Adenosine Diphosphate 153-156 myosin, heavy polypeptide 6, cardiac muscle, alpha Mus musculus 53-62 6215739-5 1982 Mean beta TG and the mean beta TG: whole blood platelet count ratio were higher in the increased and decreased responders to ADP than in the normal aggregation group, but the differences in means were not statistically significant. Adenosine Diphosphate 125-128 pro-platelet basic protein Homo sapiens 26-33 6215739-6 1982 Aspirin given to six patients at a dose sufficient to eliminate the secondary phase of ADP-induced platelet aggregation reduced mean beta TG and the mean beta TG: whole blood platelet count ratio but did not alter mean FpA and B beta 1-42. Adenosine Diphosphate 87-90 pro-platelet basic protein Homo sapiens 133-140 6215739-6 1982 Aspirin given to six patients at a dose sufficient to eliminate the secondary phase of ADP-induced platelet aggregation reduced mean beta TG and the mean beta TG: whole blood platelet count ratio but did not alter mean FpA and B beta 1-42. Adenosine Diphosphate 87-90 pro-platelet basic protein Homo sapiens 154-161 26008223-6 2015 Indeed, ectonucleotidases have the ability to either terminate P2 receptor responses initiated by nucleoside triphosphates (ATP and UTP), and/or to favor the activation of ADP (e.g. P2Y1,12,13) and UDP (e.g. P2Y6) and/or adenosine (P1) specific receptors. Adenosine Diphosphate 172-175 purinergic receptor P2Y1 Homo sapiens 182-186 6277921-6 1982 AMP, ADP, Ap4, GTP, Gp4, Ap3A, Ap5A, Gp3G, and Gp5G are noncompetitive inhibitors of the Ap4A hydrolase activity, whereas Gp4G inhibits Ap4A hydrolysis competitively with a Ki of 6 microM. Adenosine Diphosphate 5-8 nudix (nucleoside diphosphate linked moiety X)-type motif 2 Mus musculus 89-103 26008223-6 2015 Indeed, ectonucleotidases have the ability to either terminate P2 receptor responses initiated by nucleoside triphosphates (ATP and UTP), and/or to favor the activation of ADP (e.g. P2Y1,12,13) and UDP (e.g. P2Y6) and/or adenosine (P1) specific receptors. Adenosine Diphosphate 172-175 pyrimidinergic receptor P2Y6 Homo sapiens 208-212 6290286-0 1982 Candida utilis NAD+ kinase: kinetic and inhibition studies with ADP. Adenosine Diphosphate 64-67 NAD kinase Gallus gallus 15-26 6290286-7 1982 Product inhibition studies on C. utilis NAD+ kinase suggest the mechanism of NAD+, ATP addition is best described as rapid equilibrium random with multiple binding of ADP to the free enzyme and the E X ATP and E X NAD+ complexes. Adenosine Diphosphate 167-170 NAD kinase Gallus gallus 40-51 6115861-2 1981 Rat kidney 5-oxo-L-prolinase catalyzes the endergonic hydrolysis of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to form L-glutamate; the reaction is driven by and dependent on the stoichiometric concomitant hydrolysis of ATP to ADP and inorganic phosphate. Adenosine Diphosphate 249-252 5-oxoprolinase (ATP-hydrolysing) Rattus norvegicus 11-28 6112220-1 1981 The stereochemical course of the phosphoric residue transfer from ADP to water catalyzed by the (Mg2+ + Ca2+)-dependent ATPase of sarcoplasmic reticulum has been determined. Adenosine Diphosphate 66-69 dynein axonemal heavy chain 8 Homo sapiens 120-126 6261809-6 1981 The conclusion that the ATPase and ADPase activities belong to the same enzyme is based on the following results: (1) parallel effects of diethylstilbestrol and orthovanadate on both ATPase and ADPase; (2) parallel behavior of ATPase and ADPase throughout all the purification steps; (3) non-additivity of ATPase and ADPase and (4) lack of dilution of beta-32P formed from [beta-32P]-ATP by unlabelled ADP. Adenosine Diphosphate 35-38 dynein axonemal heavy chain 8 Homo sapiens 183-189 6261809-6 1981 The conclusion that the ATPase and ADPase activities belong to the same enzyme is based on the following results: (1) parallel effects of diethylstilbestrol and orthovanadate on both ATPase and ADPase; (2) parallel behavior of ATPase and ADPase throughout all the purification steps; (3) non-additivity of ATPase and ADPase and (4) lack of dilution of beta-32P formed from [beta-32P]-ATP by unlabelled ADP. Adenosine Diphosphate 35-38 dynein axonemal heavy chain 8 Homo sapiens 183-189 6261809-6 1981 The conclusion that the ATPase and ADPase activities belong to the same enzyme is based on the following results: (1) parallel effects of diethylstilbestrol and orthovanadate on both ATPase and ADPase; (2) parallel behavior of ATPase and ADPase throughout all the purification steps; (3) non-additivity of ATPase and ADPase and (4) lack of dilution of beta-32P formed from [beta-32P]-ATP by unlabelled ADP. Adenosine Diphosphate 35-38 dynein axonemal heavy chain 8 Homo sapiens 183-189 7023319-3 1981 That ADP- or collagen-treated platelets can promote the proteolytic activation of factor XII in mixtures containing kallikrein and HMW kininogen was shown by (1) the proteolytic cleavage of factor XII, (2) the development of factor XIIa coagulant activity, and (3) the proteolytic cleavage of 125I-labeled factor XII. Adenosine Diphosphate 5-8 cilia and flagella associated protein 97 Homo sapiens 131-134 6108784-6 1980 All enzymatically active ATPase preparations responded to addition of ADP with a decrease in SH reactivity. Adenosine Diphosphate 70-73 dynein axonemal heavy chain 8 Homo sapiens 25-31 7429377-2 1980 An increase in LAP levels paralleled a decrease in the respiratory control ratio and the ADP/O ratio. Adenosine Diphosphate 89-92 leucine aminopeptidase 3 Rattus norvegicus 15-18 6452449-7 1980 They allow one to explain why these nucleotide analogs are extremely strong inhibitors of oxidative phosphorylation and photophosphorylation, why the ADP derivatives cannot be phosphorylated, and why the ATP analogs are no substrates of ATPase. Adenosine Diphosphate 150-153 dynein axonemal heavy chain 8 Homo sapiens 237-243 159296-5 1979 In addition, it has been shown that the ATPase inactivated with FSBA retains the capacity to bind up to 2.2 mol of [14C]ADP/350,000 g of enzyme. Adenosine Diphosphate 120-123 dynein axonemal heavy chain 8 Homo sapiens 40-46 500014-2 1979 In binding experiments on Blue Sepharose CL-6B (an affinity gel for nucleotide-specific enzymes) it is observed that ATP citrate lyase recognizes ATP and CoA as well as ADP, 3"-AMP, and NADP, but not 5"-AMP, NAD, or adenosine. Adenosine Diphosphate 169-172 ATP citrate lyase Rattus norvegicus 117-134 153910-6 1979 The ATPase also showed a weak catalysis of an ADP-stimulated medium Pi equilibrium HOH exchange. Adenosine Diphosphate 46-49 dynein axonemal heavy chain 8 Homo sapiens 4-10 152644-2 1978 Tightly bound ATP and ADP, found on the isolated mitochondrial ATPase, exchange only slowly at pH 8, but the exchange is increased as the pH is reduced. Adenosine Diphosphate 22-25 ATP synthase F1 subunit epsilon Homo sapiens 49-69 152310-3 1978 The stretch-release cycle was repeated, and the ATPase activity (the rate of ADP liberation) [EC 3.6.1.3] was measured. Adenosine Diphosphate 77-80 dynein axonemal heavy chain 8 Homo sapiens 48-54 26190073-8 2015 We find that myosin-5 takes 1.3- to 1.5-fold longer runs on ADP Pi (young) F-actin, whereas myosin-6 takes 1.7- to 3.6-fold longer runs along ADP (old) F-actin. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 13-19 152310-14 1978 The time course of ADP liberation after one stretch-release cycle could be easily calculated from the ATPase activity of the summed durations of the isometric phase, alpha, assuming that the ATPase activation was turned off and on by the stretching and release, respectively, and that the state of cross-bridges immediately after the stretch-release was independent of alpha of the cycle. Adenosine Diphosphate 19-22 dynein axonemal heavy chain 8 Homo sapiens 102-108 152310-14 1978 The time course of ADP liberation after one stretch-release cycle could be easily calculated from the ATPase activity of the summed durations of the isometric phase, alpha, assuming that the ATPase activation was turned off and on by the stretching and release, respectively, and that the state of cross-bridges immediately after the stretch-release was independent of alpha of the cycle. Adenosine Diphosphate 19-22 dynein axonemal heavy chain 8 Homo sapiens 191-197 26551717-1 2015 Platelets are activated by the interaction with cancer cells and release enhanced levels of lipid mediators [such as thromboxane (TX)A2 and prostaglandin (PG)E2, generated from arachidonic acid (AA) by the activity of cyclooxygenase (COX)-1], granule content, including ADP and growth factors, chemokines, proteases and Wnt proteins. Adenosine Diphosphate 270-273 mitochondrially encoded cytochrome c oxidase I Homo sapiens 218-240 705701-0 1978 The role of prostaglandins in the ADP-induced aggregation of rabbit platelets shown by the use of 15-hydroxyprostaglandin dehydrogenase. Adenosine Diphosphate 34-37 carbonyl reductase [NADPH] 1 Oryctolagus cuniculus 98-135 705701-1 1978 The initial shape change and subsequent aggregation of platelets in citrated rabbit platelet-rich plasma caused by ADP in vitro was inhibited by 15-hydroxyprostaglandin dehydrogenase. Adenosine Diphosphate 115-118 carbonyl reductase [NADPH] 1 Oryctolagus cuniculus 145-182 26129975-8 2015 We revealed that S1P controls platelet aggregation via the sphingosine 1-phosphate receptor 1 through modulation of protease-activated receptor 4-peptide and adenosine diphosphate-induced platelet activation. Adenosine Diphosphate 158-179 sphingosine-1-phosphate receptor 1 Mus musculus 17-20 26129975-8 2015 We revealed that S1P controls platelet aggregation via the sphingosine 1-phosphate receptor 1 through modulation of protease-activated receptor 4-peptide and adenosine diphosphate-induced platelet activation. Adenosine Diphosphate 158-179 sphingosine-1-phosphate receptor 1 Mus musculus 59-93 147868-14 1978 As a side-observation, gizzard myosin filaments formed in the presence of ADP were found to be unusually long (longer than 2 micron), and they looked very similar to the particular filaments of skeletal myosin that were reported, by Moos, to be formed in the absence of the C protein. Adenosine Diphosphate 74-77 myosin, heavy chain 15 Gallus gallus 31-37 147868-14 1978 As a side-observation, gizzard myosin filaments formed in the presence of ADP were found to be unusually long (longer than 2 micron), and they looked very similar to the particular filaments of skeletal myosin that were reported, by Moos, to be formed in the absence of the C protein. Adenosine Diphosphate 74-77 myosin, heavy chain 15 Gallus gallus 203-209 26211589-7 2015 E-NTPDase (ATP and ADP as substrate) and E-ADA (adenosine as substrate) activities were increased in lymphocytes from SCA patients (P<0.001). Adenosine Diphosphate 19-22 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 0-9 139163-4 1977 Beef heart mitochondrial ATPase, in both the membrane-bound and isolated form, contains tightly bound ATP and ADP. Adenosine Diphosphate 110-113 ATP synthase F1 subunit epsilon Homo sapiens 11-31 26048366-5 2015 Expression of mutant tau led to decreased ADP-stimulated respiratory rates, but not uncoupler-stimulated respiratory rates. Adenosine Diphosphate 42-45 microtubule associated protein tau Homo sapiens 21-24 139163-5 1977 Each mol of ATPase contains about 2.2 mol ATP and 1.3 mol ADP. Adenosine Diphosphate 58-61 dynein axonemal heavy chain 8 Homo sapiens 12-18 14941-12 1977 The rate determining step for the steady state ATPase at higher temperatures is thought to be the step of changing from the intermediate complex showing the ATP-form of difference spectrum to that showing the ADP-form. Adenosine Diphosphate 209-212 dynein axonemal heavy chain 8 Homo sapiens 47-53 201877-5 1977 It is proposed that the uncoupler insensitivity of ATPase in coupled Zajdela hepatoma mitochondria with exogenous ATP as a substrate result from an altered functional relationship between ATPase and ADP, ATP translocase. Adenosine Diphosphate 199-202 dynein axonemal heavy chain 8 Homo sapiens 51-57 25877509-2 2015 To define how purinergic mechanisms are involved in sodium homeostasis, we used transgenic (TG) mice that globally overexpress human CD39 (hCD39, NTPDase1), an ectonucleotidase that hydrolyzes extracellular ATP/ADP to AMP, resulting in an altered extracellular purine profile. Adenosine Diphosphate 211-214 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 133-137 1036839-1 1976 In contrast to previous reports, highly purified adenosine tetraphosphate (AP4) does not induce the aggregation of platelets but inhibits the aggregation and release reaction in platelet-rich plasma promoted by ADP. Adenosine Diphosphate 211-214 transcription factor AP-4 Homo sapiens 75-78 26058047-6 2015 ADP-induced platelet reactivity by all aggregation tests correlated significantly with ADP-induced P-selectin expression and activated GPIIb/IIIa (all p<0.001). Adenosine Diphosphate 0-3 selectin P Homo sapiens 99-109 26058047-6 2015 ADP-induced platelet reactivity by all aggregation tests correlated significantly with ADP-induced P-selectin expression and activated GPIIb/IIIa (all p<0.001). Adenosine Diphosphate 87-90 selectin P Homo sapiens 99-109 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 87-90 selectin P Homo sapiens 36-46 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 191-194 selectin P Homo sapiens 36-46 1036839-2 1976 The inhibitory action of AP4 on the aggregation by ADP is compared with that of AMP and ATP. Adenosine Diphosphate 51-54 transcription factor AP-4 Homo sapiens 25-28 1036839-3 1976 The data presented suggest a competitive manner of inhibition of the ADP-induced aggregation by AP4. Adenosine Diphosphate 69-72 transcription factor AP-4 Homo sapiens 96-99 26052700-3 2015 Thrombus formation is initiated by the interaction of the GPIb-V-IX complex with collagen-bound vWF, while GPVI interaction with collagen triggers platelet activation that is reinforced by ADP and thromboxane A2. Adenosine Diphosphate 189-192 glycoprotein VI platelet Homo sapiens 107-111 25800440-3 2015 By monitoring spectral counts of specific hydroxamic acid signatures generated after the conversion of the ADP-ribose modification onto peptides by hydroxylamine hydrolysis, we undertook a thorough mass spectrometry mapping of the glutamate and aspartate ADP-ribosylation sites onto automodified PARP-1, PARP-2 and PARP-3. Adenosine Diphosphate 107-110 poly(ADP-ribose) polymerase family member 3 Homo sapiens 315-321 25800440-3 2015 By monitoring spectral counts of specific hydroxamic acid signatures generated after the conversion of the ADP-ribose modification onto peptides by hydroxylamine hydrolysis, we undertook a thorough mass spectrometry mapping of the glutamate and aspartate ADP-ribosylation sites onto automodified PARP-1, PARP-2 and PARP-3. Adenosine Diphosphate 255-258 poly(ADP-ribose) polymerase family member 3 Homo sapiens 315-321 25404528-11 2015 Over expression of Bax and caspase 3 protein, elevation of ADP/ATP ratio and LPO level in high glucose- treated PC12 cells, were significantly reduced by ALA. Adenosine Diphosphate 59-62 BCL2 associated X, apoptosis regulator Rattus norvegicus 19-22 181370-16 1976 It is suggested from these results that one or two SH groups are located in the active site of the SR ATPase, and that conformational changes are induced by the addition of ATP and ADP. Adenosine Diphosphate 181-184 dynein axonemal heavy chain 8 Homo sapiens 102-108 25936506-3 2015 Mechanochemical transduction by myosin motors on actin is coupled to unknown structural changes that result in the sequential release of inorganic phosphate (Pi) and MgADP. Adenosine Diphosphate 166-171 myosin heavy chain 14 Homo sapiens 32-38 1098-14 1976 It further supports the conclusion that Pi release from ADP by human erythrocytes (freeze-thawed) and by their isolated membranes is due to formation of ATP by adenylate kinase and hydrolysis of this generated ATP by (Ca2+ plus Mg2+)-ATPase. Adenosine Diphosphate 56-59 dynein axonemal heavy chain 8 Homo sapiens 234-240 25695398-7 2015 We show instead that PT-1 activates AMPK indirectly by inhibiting the respiratory chain and increasing cellular AMP:ATP and/or ADP:ATP ratios. Adenosine Diphosphate 127-130 zinc finger protein 77 Homo sapiens 21-25 234470-3 1975 Substances which inhibit cAMP-dependent protein kinase, namely, EDTA, ADP, and adenosine, and protein kinase modulator, each antagonized the activation of tyrosine 3-monooxygenase produced by cAMP. Adenosine Diphosphate 70-73 tyrosine hydroxylase Rattus norvegicus 155-179 25717146-5 2015 The extracellular ATP concentration is regulated by an enzymatic process, in which CD39 converts ATP and ADP into AMP, and CD73 converts AMP into adenosine. Adenosine Diphosphate 105-108 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 83-87 4377106-4 1974 These techniques were used to purify UDP-glucose dehydrogenase from a crude starting material on a phosphate-linked UDP (or ADP) matrix. Adenosine Diphosphate 124-127 UDP-glucose 6-dehydrogenase Homo sapiens 37-62 25681429-4 2015 ADP at 10(-5) M induced a 3.6 +- 0.3-fold upregulation of MCP-1 mRNA in cultured rat VSMCs, which was significantly inhibited by R-138727, the active metabolite of P2Y12 inhibitor prasugrel and siRNAs against P2Y12. Adenosine Diphosphate 0-3 C-C motif chemokine ligand 2 Rattus norvegicus 58-63 25681429-4 2015 ADP at 10(-5) M induced a 3.6 +- 0.3-fold upregulation of MCP-1 mRNA in cultured rat VSMCs, which was significantly inhibited by R-138727, the active metabolite of P2Y12 inhibitor prasugrel and siRNAs against P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 164-169 25681429-4 2015 ADP at 10(-5) M induced a 3.6 +- 0.3-fold upregulation of MCP-1 mRNA in cultured rat VSMCs, which was significantly inhibited by R-138727, the active metabolite of P2Y12 inhibitor prasugrel and siRNAs against P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 209-214 4893456-0 1969 ADP as aid in personnel shortage: enables better use of professionals. Adenosine Diphosphate 0-3 activation induced cytidine deaminase Homo sapiens 7-10 25867902-4 2015 In this study, we use NMR techniques to investigate the structural characteristics and dynamic behaviors of Hsp90 N-terminal domain in its free and AMPPCP (ATP analogue) or ADP-bound states. Adenosine Diphosphate 173-176 heat shock protein 90 alpha family class A member 1 Homo sapiens 108-113 25867902-5 2015 We demonstrated that although AMPPCP and ADP bind to almost the same region of Hsp90, significantly different effects on the dynamics behaviors of the key structural elements were observed. Adenosine Diphosphate 41-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 79-84 25867902-6 2015 AMPPCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region, while ADP binding keeps Hsp90 staying at the inactive state by increasing the conformational rigidity of the lid segment and around region. Adenosine Diphosphate 222-225 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 34048711-5 2021 Our results show that Brr2 exhibits high specificity for adenine nucleotides, with both cassettes binding ADP tighter than ATP. Adenosine Diphosphate 106-109 small nuclear ribonucleoprotein U5 subunit 200 Homo sapiens 22-26 25876076-1 2015 The poly-ADP-ribosylation (PARsylation) activity of tankyrase (TNKS) regulates diverse physiological processes including energy metabolism and wnt/beta-catenin signaling. Adenosine Diphosphate 9-12 catenin beta 1 Homo sapiens 147-159 25403716-1 2015 The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. Adenosine Diphosphate 93-114 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 22-26 25403716-1 2015 The ectonucleotidases CD39 and CD73 hydrolyze extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to generate adenosine, which binds to adenosine receptors and inhibits T-cell and natural killer (NK)-cell responses, thereby suppressing the immune system. Adenosine Diphosphate 116-119 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 22-26 33923309-3 2021 We performed a yeast-based screening to search for therapeutic drugs to be used for treating mitochondrial diseases associated with dominant mutations in the nuclear ANT1 gene, which encodes for the mitochondrial ADP/ATP carrier. Adenosine Diphosphate 213-216 Ant1p Saccharomyces cerevisiae S288C 166-170 25716855-5 2015 SCaMC-3 KO neurons show an earlier delayed Ca(2+) deregulation, and SCaMC-3-deficient mitochondria incubated with ADP or ATP-Mg had reduced Ca(2+) retention capacity, suggesting a failure to maintain matrix adenine nucleotides as a cause for premature delayed Ca(2+) deregulation. Adenosine Diphosphate 114-117 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Mus musculus 68-75 25750704-3 2015 In this regard, all responses induced by ADP analogues in astrocytes resulted to be Gi-coupled activities mediated by P2Y13 instead of P2Y1 receptors. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 118-122 25528944-1 2015 PURPOSE: ADP plays an important part in platelet aggregation by activating P2Y1 and P2Y12 receptors. Adenosine Diphosphate 9-12 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 75-79 25528944-1 2015 PURPOSE: ADP plays an important part in platelet aggregation by activating P2Y1 and P2Y12 receptors. Adenosine Diphosphate 9-12 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 84-89 24990614-5 2015 Through the enzymatic conversion of NAD into ADPR (ADP-ribose) and cADPR (cyclic ADP-ribose), CD38 increases cytoplasmic Ca(2+) concentrations, positively influencing proliferation and signaling mediated via chemokine receptors or integrins. Adenosine Diphosphate 45-48 CD38 molecule Homo sapiens 94-98 24990614-5 2015 Through the enzymatic conversion of NAD into ADPR (ADP-ribose) and cADPR (cyclic ADP-ribose), CD38 increases cytoplasmic Ca(2+) concentrations, positively influencing proliferation and signaling mediated via chemokine receptors or integrins. Adenosine Diphosphate 51-54 CD38 molecule Homo sapiens 94-98 25531508-6 2015 On the other hand, the Lyk mutation prevented severe formation of an ADP inhibited state observed for a lysine mutant and even improved the avoidance of inhibition compared with the wild-type F1. Adenosine Diphosphate 69-72 IL2 inducible T cell kinase Homo sapiens 23-26 26675066-5 2014 Low respiration with NADH-dependent substrates and increased respiration with glycerol-3-phosphate revealed complex I defects; changes in p 50 for oxygen and elevated uncoupling control ratio pointed to complex IV deficiency due to SURF1 or SCO2 mutation; high oligomycin sensitivity of state 3-ADP respiration, upregulated mitochondrial membrane potential and low content of complex V were found in lymphocytes with ATP synthase deficiency due to TMEM70 mutations. Adenosine Diphosphate 295-298 synthesis of cytochrome C oxidase 2 Homo sapiens 241-245 25130912-7 2014 In this murine SCD model, ex vivo addition of ADP or PAR4 TRAP resulted in further platelet activation as assessed by expression of activated GPIIb/IIIa and P-selectin both at 8 and 15 weeks. Adenosine Diphosphate 46-49 integrin alpha 2b Mus musculus 142-147 25059833-0 2014 (-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate-stimulated human platelet activation: suppression of heat shock protein 27 phosphorylation via p38 mitogen-activated protein kinase. Adenosine Diphosphate 50-71 heat shock protein family B (small) member 1 Homo sapiens 125-146 25059833-7 2014 EGCG attenuated the ADP-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and heat shock protein 27 (HSP27). Adenosine Diphosphate 20-23 heat shock protein family B (small) member 1 Homo sapiens 98-119 25059833-7 2014 EGCG attenuated the ADP-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and heat shock protein 27 (HSP27). Adenosine Diphosphate 20-23 heat shock protein family B (small) member 1 Homo sapiens 121-126 25100739-3 2014 To devise a different strategy, we engineered and optimized the apyrase activity of human nucleoside triphosphate diphosphohydrolase-3 (CD39L3) to enhance scavenging of extracellular adenosine diphosphate, a predominant ligand of P2Y12 receptors. Adenosine Diphosphate 183-204 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 136-142 24515258-2 2014 The reversible changes in NAA induced by mild TBI were due to a combination of transient mitochondrial malfunctioning with energy crisis (decrease in ATP and in the ATP/ADP ratio) and modulation in the gene and protein levels of N-acetyltransferase 8-like and increase of aspartoacylase levels. Adenosine Diphosphate 169-172 N-acetyltransferase 8-like Rattus norvegicus 229-255 24508339-7 2014 Addition of ADP relieves this inhibition and promotes Drp1 assembly into spirals with enhanced GTP hydrolysis. Adenosine Diphosphate 12-15 dynamin 1 like Homo sapiens 54-58 24382645-3 2014 Among eNTs and derived metabolites, the P2Y1 receptor agonist ADP strongly promotes astrogliosis and might also influence SVZ progenitor activity. Adenosine Diphosphate 62-65 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 40-53 23787765-6 2014 In AIH, CD39(pos) Tregs are decreased in frequency, exhibit limited adenosine triphosphate/adenosine diphosphate hydrolysis activity, and fail to suppress IL-17 production by effector CD4 T cells. Adenosine Diphosphate 91-112 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 8-12 24424322-7 2014 Several of these protein complexes, such as the ATP synthase and the ATP/ADP carriers, show an increase in Lys acetylation in srt2 loss-of-function mutants. Adenosine Diphosphate 73-76 sirtuin 2 Arabidopsis thaliana 126-130 24424322-8 2014 The srt2 plants display no growth phenotype but rather a metabolic phenotype with altered levels in sugars, amino acids, and ADP contents. Adenosine Diphosphate 125-128 sirtuin 2 Arabidopsis thaliana 4-8 24600452-2 2014 Nucleotides such as adenosine triphosphate and adenosine diphosphate are release from injured and necrotic cells and hydrolyzed to adenosine monophosphate and adenosine by the concerted action of the ectonucleotidases CD39 and CD73. Adenosine Diphosphate 47-68 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 218-222 24161953-4 2014 Here, we report that although some mutant Vps4 proteins form dodecameric assemblies, active wild-type Saccharomyces cerevisiae and Sulfolobus solfataricus Vps4 enzymes can form hexamers in the presence of ATP and ADP, as assayed by size-exclusion chromatography and equilibrium analytical ultracentrifugation. Adenosine Diphosphate 213-216 AAA family ATPase VPS4 Saccharomyces cerevisiae S288C 42-46 24161953-4 2014 Here, we report that although some mutant Vps4 proteins form dodecameric assemblies, active wild-type Saccharomyces cerevisiae and Sulfolobus solfataricus Vps4 enzymes can form hexamers in the presence of ATP and ADP, as assayed by size-exclusion chromatography and equilibrium analytical ultracentrifugation. Adenosine Diphosphate 213-216 AAA family ATPase VPS4 Saccharomyces cerevisiae S288C 155-159 24478091-6 2014 Finally, by using mice deficient in individual Galphai/o G-protein subunits, we demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying VAAS elicited by PTX exposure. Adenosine Diphosphate 155-158 guanine nucleotide binding protein (G protein), alpha inhibiting 3 Mus musculus 110-118 24411077-3 2014 The NH2htau -but not the physiological full-length protein- interacts with Abeta at human AD synapses and cooperates with it in inhibiting the mitochondrial ANT-1-dependent ADP/ATP exchange. Adenosine Diphosphate 173-176 solute carrier family 25 member 4 Homo sapiens 157-162 24211510-7 2014 RESULTS: The ADP-stimulated platelet fibrinogen binding, P-selectin expression, and platelet aggregation were lower on treatment with clopidogrel compared with baseline (p < 0.0001), but returned to baseline levels by 7 days after discontinuation. Adenosine Diphosphate 13-16 selectin P Homo sapiens 57-67 33636162-8 2021 In contrast, ablation of iPLA2gamma prevented the HF-induced hypersensitivity of mPTP opening to calcium and maintained ADP-mediated resistance to mPTP opening. Adenosine Diphosphate 120-123 patatin-like phospholipase domain containing 8 Mus musculus 25-35 24462203-3 2014 Here we present a functional characterization of 2.5 A and 3.25 A X-ray crystal and small-angle X-ray scattering structures of RNase L bound to a natural 2-5A activator with and without ADP or the nonhydrolysable ATP mimetic AMP-PNP. Adenosine Diphosphate 186-189 ribonuclease L Homo sapiens 127-134 33557943-6 2021 By using this antibody as a tool, we showed that protein kinase C (PKC)-mediated Dab2-pSer24 was a conservative signaling event when human platelets were activated by the platelet agonists such as thrombin, collagen, ADP, 12-O-tetradecanoylphorbol-13-acetate, and the thromboxane A2 activator U46619. Adenosine Diphosphate 217-220 DAB adaptor protein 2 Homo sapiens 81-85 24419385-8 2014 Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the `ATP-like" configuration, with the neck linker docked to the catalytic core. Adenosine Diphosphate 24-27 kinesin family member 15 Homo sapiens 9-14 33306443-8 2021 Receptor profiling studies demonstrated presence of P2Y1 and P2Y2 receptors, using ATP, UTP, ADP and the subtype specific agonists MRS2365 (P2Y1) and 2-thio-UTP (P2Y2)). Adenosine Diphosphate 93-96 purinergic receptor P2Y1 Bos taurus 52-56 33513822-11 2021 A possible mechanism of the effects of the two drugs together with polyP on mucin expression is proposed based on the scavenging of free oxygen species and the generation of ADP/ATP from the polyP, which is needed for the organization of the protective mucin-based mucus layer. Adenosine Diphosphate 174-177 LOC100508689 Homo sapiens 76-81 23619558-9 2014 However, the addition of FLAG tag to the C-terminus of the mouse GDH left the recombinant protein fivefold less sensitive to ADP activation. Adenosine Diphosphate 125-128 glutamate dehydrogenase 1 Homo sapiens 65-68 24078249-0 2014 Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex. Adenosine Diphosphate 15-18 SWI5 dependent homologous recombination repair protein 1 Homo sapiens 75-79 24078249-6 2014 Importantly, we show that SWI5-SFR1 acts by facilitating the release of ADP from the presynaptic filament. Adenosine Diphosphate 72-75 SWI5 dependent homologous recombination repair protein 1 Homo sapiens 31-35 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 96-145 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 148-154 24940685-2 2014 Extracellular pathway that converts ATP and ADP to AMP, and AMP to adenosine mainly mediated by ecto-nucleoside triphosphate diphosphohydrolase 1, (ENTPD1 or CD39) and ecto-5"-nucleotidase (E5NT or CD73) respectively, is considered as important target for xenograft protection. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 158-162 24940685-9 2014 A marked increase of adenosine formation from ADP or ATP was observed only in E5NT/ENTPD1-transfected cells (11.7+-0.1 and 5.7+-2.2 muM respectively) but not in any other condition studied. Adenosine Diphosphate 46-49 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 83-89 33513822-11 2021 A possible mechanism of the effects of the two drugs together with polyP on mucin expression is proposed based on the scavenging of free oxygen species and the generation of ADP/ATP from the polyP, which is needed for the organization of the protective mucin-based mucus layer. Adenosine Diphosphate 174-177 LOC100508689 Homo sapiens 253-258 33264433-0 2021 ADP-ribosylation of histone variant H2AX promotes base excision repair. Adenosine Diphosphate 0-3 H2A.X variant histone Homo sapiens 36-40 24190032-3 2014 ADP activates platelets through three purinoceptor subtypes, the G(q)-coupled P2Y(1) receptor, G(i)-coupled P2Y(12) receptor and P2X(1) ligand-gated cation channel. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 78-93 24310605-10 2014 ADP induced endothelium-dependent vasorelaxation which was inhibited by MRS2179, a selective P2Y(1) receptor antagonist, or SCH58261, a selective adenosine A(2A) receptor antagonist. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 93-108 24310605-12 2014 The relaxation induced by ADP is mediated by P2Y(1) and A(2A) adenosine receptors. Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 45-51 33264433-4 2021 In-depth studies performed with wild-type H2AX and the ADP-ribosylation-deficient E141A mutant suggest that H2AX ADP-ribosylation plays a critical role in base excision repair (BER). Adenosine Diphosphate 55-58 H2A.X variant histone Homo sapiens 108-112 33264433-4 2021 In-depth studies performed with wild-type H2AX and the ADP-ribosylation-deficient E141A mutant suggest that H2AX ADP-ribosylation plays a critical role in base excision repair (BER). Adenosine Diphosphate 113-116 H2A.X variant histone Homo sapiens 108-112 24269480-1 2013 A number of new amine scaffolds with good inhibitory activity in the ADP-induced platelet aggregation assay have been found to be potent antagonists of the P2Y1 receptor. Adenosine Diphosphate 69-72 purinergic receptor P2Y1 Homo sapiens 156-169 33264433-6 2021 Moreover, loss of this ADP-ribosylation enhances serine-139 phosphorylation of H2AX (gammaH2AX) upon oxidative DNA damage and erroneously causes the accumulation of DNA double-strand break (DSB) response factors. Adenosine Diphosphate 23-26 H2A.X variant histone Homo sapiens 79-83 33264433-7 2021 Taken together, these results reveal that H2AX ADP-ribosylation not only facilitates BER repair, but also suppresses the gammaH2AX-mediated DSB response. Adenosine Diphosphate 47-50 H2A.X variant histone Homo sapiens 42-46 33176449-6 2021 Lox-1 is also expressed in platelets, where it enhances platelet activation, adhesion to endothelial cells, and ADP-mediated aggregation, thereby favoring thrombus formation. Adenosine Diphosphate 112-115 oxidized low density lipoprotein receptor 1 Homo sapiens 0-5 24244016-7 2013 LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 receptors. Adenosine Diphosphate 45-48 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 75-80 32857889-2 2020 Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis. Adenosine Diphosphate 98-101 fuzzy planar cell polarity protein Homo sapiens 60-63 23806663-0 2013 Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Adenosine Diphosphate 30-33 phosphatase and tensin homolog Homo sapiens 8-12 23806663-3 2013 These studies have identified important roles for the phosphatase PTEN in ADP-dependent modulation of the endothelial isoform of nitric oxide synthase (eNOS) as well as of lipid and protein kinase pathways in endothelial cells. Adenosine Diphosphate 74-77 phosphatase and tensin homolog Homo sapiens 66-70 23806663-4 2013 We find that ADP-promoted eNOS activation as well as phosphorylation of p38 MAPK are enhanced by siRNA-mediated PTEN knockdown. Adenosine Diphosphate 13-16 phosphatase and tensin homolog Homo sapiens 112-116 23806663-5 2013 However, the increase in ADP-dependent eNOS activation promoted by PTEN knockdown is abrogated by siRNA-mediated knockdown of p38 MAPK. Adenosine Diphosphate 25-28 phosphatase and tensin homolog Homo sapiens 67-71 23806663-6 2013 These findings indicate that PTEN tonically suppresses both p38 phosphorylation as well as ADP-stimulated eNOS activity. Adenosine Diphosphate 91-94 phosphatase and tensin homolog Homo sapiens 29-33 23806663-9 2013 Because these complex lipids activate the small GTPase Rac1, we explored the role of PTEN in ADP-modulated Rac1 activation. Adenosine Diphosphate 93-96 phosphatase and tensin homolog Homo sapiens 85-89 23806663-10 2013 We used a FRET biosensor for Rac1 to show that ADP-dependent Rac1 activation is blocked by siRNA-mediated PTEN knockdown. Adenosine Diphosphate 47-50 phosphatase and tensin homolog Homo sapiens 106-110 33269349-1 2020 The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. Adenosine Diphosphate 113-116 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 71-75 23629754-5 2013 Our study demonstrated that ADP stimulation of P2Y13 R(+/+) (but not P2Y13 R(-/-) ) adherent bone marrow stromal cells (BMSCs) increased significantly the formation of alkaline phosphatase-colony-forming units (CFU-ALP) as well as the expression of osteoblastic markers (osterix, alkaline phosphatase, and collagen I) involved in the maturation of preosteoblasts into osteoblasts. Adenosine Diphosphate 28-31 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 47-52 33158052-6 2020 In addition, CP-induced PARP-1 activation led to ADP-ribosylation of HMGB1, which consequently developed autophagy as evident by the LC3I/II ratio. Adenosine Diphosphate 49-52 high mobility group box 1 Homo sapiens 69-74 33028677-6 2020 NMR and electron cryomicroscopy data have been used as restraints in molecular dynamics trajectories to develop structural ensembles for p47-p97 complexes in adenosine diphosphate (ADP)- and adenosine triphosphate (ATP)-bound conformations, highlighting differences in interactions in the two states. Adenosine Diphosphate 181-184 valosin containing protein Homo sapiens 141-144 24211213-11 2013 Because 1/Kapp reflects the affinity of F-actin for the myosin-ADP-phosphate intermediate (M.ADP.Pi) through the weak binding, these data suggest that the bulkiness or the aromatic nature of the tyrosin-143 is important for the initial binding of the M.ADP.Pi intermediate with F-actin but not for later processes such as the phosphate release. Adenosine Diphosphate 63-66 myosin heavy chain 14 Homo sapiens 56-62 24211213-11 2013 Because 1/Kapp reflects the affinity of F-actin for the myosin-ADP-phosphate intermediate (M.ADP.Pi) through the weak binding, these data suggest that the bulkiness or the aromatic nature of the tyrosin-143 is important for the initial binding of the M.ADP.Pi intermediate with F-actin but not for later processes such as the phosphate release. Adenosine Diphosphate 93-96 myosin heavy chain 14 Homo sapiens 56-62 23941770-9 2013 ATP metabolites including adenosine 5"-diphosphate (ADP), adenosine 5"-monophosphate (AMP), and adenosine inhibited MMP-1 expression, but ADP-betaS, a stable ADP, did not, suggesting that adenosine converted from ATP by the action of CD39/ENTPD and CD73/5"-NT may contribute to MMP-1 inhibition. Adenosine Diphosphate 26-50 matrix metallopeptidase 1 Homo sapiens 116-121 23876319-4 2013 Predominantly in astrocytes, Ca(2+) baseline was elevated by adenosine diphosphate (ADP) and adenosine triphosphate (ATP) acting via P2Y1 and P2X7 receptors, likely causing the release of glutamate and glutamine. Adenosine Diphosphate 61-82 purinergic receptor P2Y1 Homo sapiens 133-137 32683309-0 2020 Molecular basis for the MacroD1-mediated hydrolysis of ADP-ribosylation. Adenosine Diphosphate 55-58 mono-ADP ribosylhydrolase 1 Homo sapiens 24-31 23897816-6 2013 Here we show using isothermal titration calorimetry that mammalian GMF has very low affinity for ATP-bound Arp2/3 complex but binds ADP-bound Arp2/3 complex with 0.7 muM affinity. Adenosine Diphosphate 132-135 actin related protein 2 Homo sapiens 142-146 32683309-6 2020 Moreover, we found that MacroD1 was recruited to the sites of DNA damage via recognition of ADP-ribosylation at DNA lesions. Adenosine Diphosphate 92-95 mono-ADP ribosylhydrolase 1 Homo sapiens 24-31 23484959-5 2013 Expression of CD62P on the surface of platelets was examined in the native state, after the addition of thrombin or ADP. Adenosine Diphosphate 116-119 selectin P Homo sapiens 14-19 32783916-9 2020 We also observe ADP-Mg2+ bound in the nsp12 N-terminal nidovirus RdRp-associated nucleotidyltransferase domain, detailing a new pocket for anti-viral therapy development. Adenosine Diphosphate 16-19 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 65-69 23686368-6 2013 Supernatants collected from HIV-infected macrophages (HIV/MDM) contained large amounts of ATP, ADP, AMP and small amounts of adenosine, in addition to glutamate. Adenosine Diphosphate 95-98 secreted LY6/PLAUR domain containing 1 Homo sapiens 58-61 32445636-2 2020 NPP4 on the surface of endothelial cells was reported to promote platelet aggregation by hydrolyzing Ap3A to ADP, which activates pro-thrombotic G protein-coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 109-112 ectonucleotide pyrophosphatase/phosphodiesterase 4 Homo sapiens 0-4 24056384-1 2013 The protein adenine nucleotide translocase (ANT) is localized in the mitochondrial inner membrane and plays an essential role in transporting ADP into the mitochondrial matrix and ATP out from the matrix for cell utilization. Adenosine Diphosphate 142-145 solute carrier family 25 member 6 Homo sapiens 12-42 24056384-1 2013 The protein adenine nucleotide translocase (ANT) is localized in the mitochondrial inner membrane and plays an essential role in transporting ADP into the mitochondrial matrix and ATP out from the matrix for cell utilization. Adenosine Diphosphate 142-145 solute carrier family 25 member 6 Homo sapiens 44-47 24056384-7 2013 A large chemical library (>100,000 small molecules) was screened by molecular docking and effects of these compounds on ADP/ATP exchange through ANT4 were examined using yeast mitochondria expressing human ANT4. Adenosine Diphosphate 123-126 solute carrier family 25 member 31 Homo sapiens 148-152 23575529-3 2013 Here, we show that in the presence of extracellular NAD(+) , ART2.2 caused ADP-ribosylation of CD8-beta on murine CD8(+) T cells in vitro and in vivo. Adenosine Diphosphate 75-78 ADP-ribosyltransferase 2b Mus musculus 61-67 23735588-8 2013 In these subjects, annexin V was less effective in inhibiting both basal and ADP-induced TG. Adenosine Diphosphate 77-80 annexin A5 Homo sapiens 19-28 23716697-3 2013 Here, we report that ADP-ribosylation of CtBP1-S/BARS by BFA occurs via a nonconventional mechanism that comprises two steps: (i) synthesis of a BFA-ADP-ribose conjugate by the ADP-ribosyl cyclase CD38 and (ii) covalent binding of the BFA-ADP-ribose conjugate into the CtBP1-S/BARS NAD(+)-binding pocket. Adenosine Diphosphate 21-24 CD38 molecule Homo sapiens 197-201 23588296-0 2013 Thrombopoietin amplifies ADP-induced HSP27 phosphorylation in human platelets: importance of pre-treatment. Adenosine Diphosphate 25-28 heat shock protein family B (small) member 1 Homo sapiens 37-42 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 37-58 heat shock protein family B (small) member 1 Homo sapiens 92-113 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 37-58 heat shock protein family B (small) member 1 Homo sapiens 115-120 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 60-63 heat shock protein family B (small) member 1 Homo sapiens 92-113 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 60-63 heat shock protein family B (small) member 1 Homo sapiens 115-120 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 201-204 heat shock protein family B (small) member 1 Homo sapiens 92-113 23588296-3 2013 We have previously reported that the adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via the p38 mitogen-activated protein (MAP) kinase pathway correlates with the ADP-induced platelet-derived growth factor (PDGF)-AB secretion and the release of soluble CD40 ligand (sCD40L) from human platelets. Adenosine Diphosphate 201-204 heat shock protein family B (small) member 1 Homo sapiens 115-120 23420347-4 2013 Here we obtained hGDH1 and hGDH2 in recombinant form and studied their Km for ammonia in the presence of 1.0 mM ADP. Adenosine Diphosphate 112-115 glutamate dehydrogenase 1 Homo sapiens 17-22 23602659-3 2013 Here, we present the crystal structures of human SphK1 in the apo form and in complexes with a substrate sphingosine-like lipid, ADP, and an inhibitor at 2.0-2.3 A resolution. Adenosine Diphosphate 129-132 sphingosine kinase 1 Homo sapiens 49-54 23487038-5 2013 Moreover, BAL1 physically interacts with both STAT1alpha and STAT1beta through its macrodomains in an ADP-ribosylation-dependent manner. Adenosine Diphosphate 102-105 poly(ADP-ribose) polymerase family member 9 Homo sapiens 10-14 23454361-0 2013 Crystal structure analysis of human Sirt2 and its ADP-ribose complex. Adenosine Diphosphate 50-53 sirtuin 2 Homo sapiens 36-41 23340049-6 2013 Obesity was independently associated with higher residual platelet reactivity by the VASP assay and MEA ADP, and with platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP (all P <= 0.04). Adenosine Diphosphate 201-204 selectin P Homo sapiens 150-160 23387322-4 2013 Treatment with ADP resulted in delayed Rab5-dependent internalization of P341A when compared with WT P2Y12 . Adenosine Diphosphate 15-18 RAB5A, member RAS oncogene family Homo sapiens 39-43 23215951-7 2013 In porcine mesenteric arteries, PaCoA and the P2Y1 receptor antagonist MRS2500 blocked ADP-mediated endothelium-dependent relaxations; in contrast, they were ineffective against ADP-mediated endothelium-independent relaxation in porcine coronary arteries (which does not involve P2Y1 receptors). Adenosine Diphosphate 87-90 purinergic receptor P2Y1 Homo sapiens 46-59 23215951-7 2013 In porcine mesenteric arteries, PaCoA and the P2Y1 receptor antagonist MRS2500 blocked ADP-mediated endothelium-dependent relaxations; in contrast, they were ineffective against ADP-mediated endothelium-independent relaxation in porcine coronary arteries (which does not involve P2Y1 receptors). Adenosine Diphosphate 87-90 purinergic receptor P2Y1 Homo sapiens 46-50 23215951-8 2013 Calcium responses evoked by ADP activation of endogenous P2Y1 receptors in HEK293 cells were inhibited in the presence of PaCoA, which failed to alter responses to UTP (acting at endogenous P2Y(2/4) receptors). Adenosine Diphosphate 28-31 purinergic receptor P2Y1 Homo sapiens 57-61 22212466-11 2013 In contrast to UFH, bivalirudin reduced the P-selectin expression of unstimulated and ADP-induced platelets post-PCI. Adenosine Diphosphate 86-89 selectin P Homo sapiens 44-54 22212466-13 2013 Moreover, bivalirudin reduced the TF activity of platelet-derived microparticles postinduction with TRAP or ADP. Adenosine Diphosphate 108-111 coagulation factor III, tissue factor Homo sapiens 34-36 23207595-7 2013 In the acute and organotypic slices, CaM stimulated and ADP inhibited calcium-dependent TRPM4 channels and CaMKII augmented synaptic drive currents. Adenosine Diphosphate 56-59 transient receptor potential cation channel subfamily M member 4 Homo sapiens 88-93 23506884-5 2013 The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A5, SLC25A6 and SLC25A31 genes, in human diseases and of the efforts made at designing different model systems to study this carrier and the associated pathologies through biochemical, genetic, and structural approaches. Adenosine Diphosphate 93-96 solute carrier family 25 member 4 Homo sapiens 125-132 23506884-5 2013 The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A5, SLC25A6 and SLC25A31 genes, in human diseases and of the efforts made at designing different model systems to study this carrier and the associated pathologies through biochemical, genetic, and structural approaches. Adenosine Diphosphate 93-96 solute carrier family 25 member 6 Homo sapiens 143-150 23506884-5 2013 The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A5, SLC25A6 and SLC25A31 genes, in human diseases and of the efforts made at designing different model systems to study this carrier and the associated pathologies through biochemical, genetic, and structural approaches. Adenosine Diphosphate 93-96 solute carrier family 25 member 31 Homo sapiens 155-163 23570413-7 2013 However, significantly lower P-selectin expression was found in the hyperprolactinemic group when platelets were activated by ADP (5 and 10 muM) or PAR4-AP. Adenosine Diphosphate 126-129 selectin P Homo sapiens 29-39 23570413-9 2013 For all samples, inverse significant correlations between P-selectin expression and prolactin concentration were found for both 5 muM ADP (r = - 0.61, p < 0.01), 10 muM ADP (r = - 0.62, p < 0.001) and PAR4-AP (r = - 0.69, p < 0.001). Adenosine Diphosphate 134-137 selectin P Homo sapiens 58-68 23570413-9 2013 For all samples, inverse significant correlations between P-selectin expression and prolactin concentration were found for both 5 muM ADP (r = - 0.61, p < 0.01), 10 muM ADP (r = - 0.62, p < 0.001) and PAR4-AP (r = - 0.69, p < 0.001). Adenosine Diphosphate 172-175 selectin P Homo sapiens 58-68 23389750-8 2013 P-selectin expression decreased, when measured without and upon addition of ADP, increased in the presence of TRAP-6, and remained unchanged after addition of Collagen. Adenosine Diphosphate 76-79 selectin P Homo sapiens 0-10 23490430-2 2013 ADP induces platelet aggregation through two purinergic receptors P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 66-70 23058232-8 2013 Among them, three overexpressed proteins of the ADP-l-glycero-d-mannoheptose-6-epimerase RfaD, thymidylate synthase ThyA and putative macrophage infectivity potentiator-related protein Mip were confirmed as molecular targets that modulated adherence and invasion capacities of the DeltaompP2 mutant. Adenosine Diphosphate 48-51 major intrinsic protein of lens fiber Sus scrofa 185-188 23173940-0 2013 The substrate specificity of the human ADP/ATP carrier AAC1. Adenosine Diphosphate 39-42 solute carrier family 25 member 4 Homo sapiens 55-59 23173940-2 2013 Here the substrate specificity of the human mitochondrial ADP/ATP carrier AAC1 was determined by two different approaches. Adenosine Diphosphate 58-61 solute carrier family 25 member 4 Homo sapiens 74-78 23173940-6 2013 A large number of nucleotides were tested, but only ADP and ATP are suitable substrates for human AAC1, demonstrating a very narrow specificity. Adenosine Diphosphate 52-55 solute carrier family 25 member 4 Homo sapiens 98-102 22941026-0 2013 High glucose and free fatty acids induce beta cell apoptosis via autocrine effects of ADP acting on the P2Y(13) receptor. Adenosine Diphosphate 86-89 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 104-111 23368907-1 2013 Two distinct G protein-coupled purinergic receptors, P2Y1 and P2Y12, mediate ADP-driven platelet activation. Adenosine Diphosphate 77-80 purinergic receptor P2Y12 Rattus norvegicus 62-67 23123429-0 2013 Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Adenosine Diphosphate 18-21 CD38 molecule Homo sapiens 44-48 23123429-7 2013 In this study, we have successfully identified the D226/Q226 and K129 residues of the two CD38 mutants being the ADP-ribosylation sites using precursor ion scanning hybrid quadrupole linear ion trap mass spectrometry. Adenosine Diphosphate 113-116 CD38 molecule Homo sapiens 90-94 23245937-5 2013 The triple combination of P2Y(1), P2Y(12), and TxA(2) receptor antagonists also significantly shifted adenosine diphosphate (ADP)-stimulated platelet glycoprotein IIb/IIIa receptor and P-selectin expression compared to individual or dual antagonists. Adenosine Diphosphate 102-123 purinergic receptor P2Y1 Homo sapiens 26-32 23245937-5 2013 The triple combination of P2Y(1), P2Y(12), and TxA(2) receptor antagonists also significantly shifted adenosine diphosphate (ADP)-stimulated platelet glycoprotein IIb/IIIa receptor and P-selectin expression compared to individual or dual antagonists. Adenosine Diphosphate 102-123 selectin P Homo sapiens 185-195 23245937-5 2013 The triple combination of P2Y(1), P2Y(12), and TxA(2) receptor antagonists also significantly shifted adenosine diphosphate (ADP)-stimulated platelet glycoprotein IIb/IIIa receptor and P-selectin expression compared to individual or dual antagonists. Adenosine Diphosphate 125-128 purinergic receptor P2Y1 Homo sapiens 26-32 23245937-5 2013 The triple combination of P2Y(1), P2Y(12), and TxA(2) receptor antagonists also significantly shifted adenosine diphosphate (ADP)-stimulated platelet glycoprotein IIb/IIIa receptor and P-selectin expression compared to individual or dual antagonists. Adenosine Diphosphate 125-128 selectin P Homo sapiens 185-195 23149844-2 2013 Gas6 null (-/-) mice are protected from lethal venous and arterial thromboembolism through platelet signaling defects induced only by 5 muM ADP and 10 muM of the thromboxane analog, U46619. Adenosine Diphosphate 140-143 growth arrest specific 6 Mus musculus 0-4 23231323-2 2013 The results show that the effects of these proteins on the thermal stability of G-actin depend on the nucleotide, ATP or ADP, bound in the nucleotide-binding cleft between actin subdomains 2 and 4. Adenosine Diphosphate 121-124 actin Oryctolagus cuniculus 82-87 23231323-2 2013 The results show that the effects of these proteins on the thermal stability of G-actin depend on the nucleotide, ATP or ADP, bound in the nucleotide-binding cleft between actin subdomains 2 and 4. Adenosine Diphosphate 121-124 actin Oryctolagus cuniculus 172-177 23289424-5 2013 RESULTS: In experiments with isolated histones, it was found that ADP-ribosylation of H3 by ARTD1 prevents H3 methylation by SET7/9. Adenosine Diphosphate 66-69 SET domain containing 7, histone lysine methyltransferase Homo sapiens 125-131 22879063-2 2013 P2Y(1) and P2Y(12) both respond to ADP, but while P2Y(1) links to PLC and elevates cytosolic Ca(2+) concentration, P2Y(12) negatively couples to adenylate cyclase, maintaining cAMP at low level. Adenosine Diphosphate 35-38 purinergic receptor P2Y1 Homo sapiens 0-6 22864626-9 2013 Binding conformation of P-gp co-crystallized complexes with ADP, AMP-PNP (Adenylyl-imidodiphosphate), and ATP were compared with piperine. Adenosine Diphosphate 60-63 PGP Canis lupus familiaris 24-28 23658513-2 2013 A subpopulation of human Treg expresses the ectoenzyme CD39, which in association with CD73 converts ATP/ADP/AMP to adenosine. Adenosine Diphosphate 105-108 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 55-59 22930330-9 2012 Internal strain within the myosin molecule or by neighboring myosin motors may slow ADP release which becomes rate-limiting in the in vitro motility assay. Adenosine Diphosphate 84-87 myosin heavy chain 14 Homo sapiens 27-33 22930330-9 2012 Internal strain within the myosin molecule or by neighboring myosin motors may slow ADP release which becomes rate-limiting in the in vitro motility assay. Adenosine Diphosphate 84-87 myosin heavy chain 14 Homo sapiens 61-67 23083103-0 2012 Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation. Adenosine Diphosphate 104-107 purinergic receptor P2Y1 Homo sapiens 63-67 22846899-6 2012 E-NTPDase (ATP and ADP as substrates) and E-ADA (adenosine as substrate) activities were decreased in lymphocytes from IFCD patients (P<0.05 and P<0.01, respectively), while the E-NTPDase1 expression presented no changes in these patients. Adenosine Diphosphate 19-22 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 0-9 22995898-3 2012 We demonstrate that NPP4 is present on the surface of vascular endothelium, where it hydrolyzes Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Adenosine Diphosphate 114-117 ectonucleotide pyrophosphatase/phosphodiesterase 4 Homo sapiens 20-24 22995898-6 2012 Finally, by using ADP receptor blockade we confirm that NPP4 mediates platelet aggregation via release of ADP from Ap3A and activation of ADP receptors. Adenosine Diphosphate 18-21 ectonucleotide pyrophosphatase/phosphodiesterase 4 Homo sapiens 56-60 22995898-7 2012 Collectively, these studies define the biologic and enzymatic basis for NPP4 and Ap3A activity in platelet aggregation in vitro and suggest that NPP4 promotes hemostasis in vivo by augmenting ADP-mediated platelet aggregation at the site of vascular injury. Adenosine Diphosphate 192-195 ectonucleotide pyrophosphatase/phosphodiesterase 4 Homo sapiens 145-149 22689668-1 2012 BACKGROUND: The interaction of adenosine diphosphate with its P2Y(1) and P2Y(12) receptors on platelets is important for platelet function. Adenosine Diphosphate 31-52 purinergic receptor P2Y1 Homo sapiens 62-68 23102217-2 2012 It is activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that increase cellular ADP:ATP and/or AMP:ATP ratios. Adenosine Diphosphate 114-117 serine/threonine kinase 11 Homo sapiens 63-67 22996695-7 2012 In platelets, ADP stimulation of P2RY12 resulted in GTPase Ras-related protein (RAP1) activation and subsequent alphaIIbbeta3 integrin activation. Adenosine Diphosphate 14-17 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 33-39 22996695-8 2012 Likewise, we found that ADP stimulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its effects were substantially blunted in P2ry12-/- OCs. Adenosine Diphosphate 24-27 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 165-171 22996695-9 2012 In vivo, P2ry12-/- mice were partially protected from pathologic bone loss associated with serum transfer arthritis, tumor growth in bone, and ovariectomy-induced osteoporosis: all conditions associated with increased extracellular ADP. Adenosine Diphosphate 232-235 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 9-15 22752265-2 2012 Actin-binding substantially reduces the affinity of ATP for myosin, but the effect of actin on myosin"s ADP affinity is quite variable among myosin isoforms, serving as the principal mechanism for tuning the actomyosin system to specific physiological purposes. Adenosine Diphosphate 104-107 myosin heavy chain 14 Homo sapiens 95-101 22752265-2 2012 Actin-binding substantially reduces the affinity of ATP for myosin, but the effect of actin on myosin"s ADP affinity is quite variable among myosin isoforms, serving as the principal mechanism for tuning the actomyosin system to specific physiological purposes. Adenosine Diphosphate 104-107 myosin heavy chain 14 Homo sapiens 95-101 22752265-7 2012 We conclude that myosin"s Cys content and lever arm both allosterically modulate the reciprocal affinities of myosin for ADP and actin, a key determinant of the biological functions of myosin isoforms. Adenosine Diphosphate 121-124 myosin heavy chain 14 Homo sapiens 17-23 22752265-7 2012 We conclude that myosin"s Cys content and lever arm both allosterically modulate the reciprocal affinities of myosin for ADP and actin, a key determinant of the biological functions of myosin isoforms. Adenosine Diphosphate 121-124 myosin heavy chain 14 Homo sapiens 110-116 22752265-7 2012 We conclude that myosin"s Cys content and lever arm both allosterically modulate the reciprocal affinities of myosin for ADP and actin, a key determinant of the biological functions of myosin isoforms. Adenosine Diphosphate 121-124 myosin heavy chain 14 Homo sapiens 110-116 22684149-6 2012 We report crystal structures of ADP-bound Get3 in complex with the cytoplasmic domain of Get1 (Get1CD) in open and semi-open conformations at 3.0- and 4.5-A resolutions, respectively. Adenosine Diphosphate 32-35 guided entry of tail-anchored proteins factor 1 Homo sapiens 89-93 22684149-6 2012 We report crystal structures of ADP-bound Get3 in complex with the cytoplasmic domain of Get1 (Get1CD) in open and semi-open conformations at 3.0- and 4.5-A resolutions, respectively. Adenosine Diphosphate 32-35 guided entry of tail-anchored proteins factor 1 Homo sapiens 95-101 22978616-4 2012 This strategy was tested on a set of four human genes encoding isoforms 1 to 4 of the mitochondrial ADP/ATP carrier ANT. Adenosine Diphosphate 100-103 solute carrier family 25 member 6 Homo sapiens 116-119 22857951-5 2012 Dcx specifically enhances binding of the ADP-bound Kif1a motor domain to MTs. Adenosine Diphosphate 41-44 kinesin family member 1A Homo sapiens 51-56 22831801-1 2012 The P2Y(1) receptor (P2Y(1)R) is a G protein-coupled receptor naturally activated by extracellular ADP. Adenosine Diphosphate 99-102 purinergic receptor P2Y1 Homo sapiens 4-19 22831801-1 2012 The P2Y(1) receptor (P2Y(1)R) is a G protein-coupled receptor naturally activated by extracellular ADP. Adenosine Diphosphate 99-102 purinergic receptor P2Y1 Homo sapiens 21-28 22751660-4 2012 This contrasts with Escherichia coli SCS, which uses GDP/GTP but prefers ADP/ATP. Adenosine Diphosphate 73-76 succinate-CoA ligase GDP/ADP-forming subunit alpha Sus scrofa 37-40 22613024-1 2012 Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AMP, which then is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine. Adenosine Diphosphate 173-176 5' nucleotidase, ecto Mus musculus 281-301 22613024-1 2012 Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AMP, which then is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine. Adenosine Diphosphate 173-176 5' nucleotidase, ecto Mus musculus 303-307 22456341-8 2012 Lgals1(-/-) platelets exhibited normal aggregation to PAR4, ADP, arachidonic acid, or collagen but abnormal ATP release at low collagen concentrations. Adenosine Diphosphate 60-63 galectin 1 Homo sapiens 0-6 22249129-6 2012 P2Y(1) and P2Y(6) receptor blockers, MRS2500 and MRS2578, blocked the effect of ADP and UDP. Adenosine Diphosphate 80-83 purinergic receptor P2Y1 Homo sapiens 0-6 22249129-6 2012 P2Y(1) and P2Y(6) receptor blockers, MRS2500 and MRS2578, blocked the effect of ADP and UDP. Adenosine Diphosphate 80-83 pyrimidinergic receptor P2Y6 Homo sapiens 11-26 22249129-7 2012 The signal that transmitted the proliferative activity of ADP and UDP was transducted to phospholipase C, inositol 1,4,5-triphosphate receptor, and protein kinase C. These results indicate involvement of P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation. Adenosine Diphosphate 58-61 purinergic receptor P2Y1 Homo sapiens 204-210 22249129-7 2012 The signal that transmitted the proliferative activity of ADP and UDP was transducted to phospholipase C, inositol 1,4,5-triphosphate receptor, and protein kinase C. These results indicate involvement of P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation. Adenosine Diphosphate 58-61 pyrimidinergic receptor P2Y6 Homo sapiens 215-221 22249129-7 2012 The signal that transmitted the proliferative activity of ADP and UDP was transducted to phospholipase C, inositol 1,4,5-triphosphate receptor, and protein kinase C. These results indicate involvement of P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation. Adenosine Diphosphate 235-238 purinergic receptor P2Y1 Homo sapiens 204-210 22249129-7 2012 The signal that transmitted the proliferative activity of ADP and UDP was transducted to phospholipase C, inositol 1,4,5-triphosphate receptor, and protein kinase C. These results indicate involvement of P2Y(1) and P2Y(6) receptors in ADP- and UDP-stimulated proliferation. Adenosine Diphosphate 235-238 pyrimidinergic receptor P2Y6 Homo sapiens 215-221 22675116-2 2012 During its ATPase cycle p97 functions as an ATP motor, converting the chemical energy released upon hydrolysis of ATP to ADP into mechanical work, which is then directed toward the proteins that serve as substrates. Adenosine Diphosphate 121-124 melanotransferrin Homo sapiens 24-27 22555559-1 2012 The peroxisomal protein PXN encoded by the Arabidopsis gene At2g39970 has very recently been found to transport NAD+, NADH, AMP and ADP. Adenosine Diphosphate 132-135 Mitochondrial substrate carrier family protein Arabidopsis thaliana 24-27 22348955-5 2012 The Kir6.1/SUR2B channel is regulated by intracellular ATP and ADP. Adenosine Diphosphate 63-66 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 4-10 22075250-8 2012 Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12-dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively. Adenosine Diphosphate 179-182 RAS guanyl releasing protein 1 Homo sapiens 81-92 21722325-7 2012 Unstimulated platelet fibrinogen binding (P = 0.016) and ADP-stimulated P-selectin expression (P = 0.008) were lower in VA compared with venous samples. Adenosine Diphosphate 57-60 selectin P Homo sapiens 72-82 22187496-8 2012 This report expands the clinical spectrum of ANT1-related human diseases, and emphasises the crucial role of the mitochondrial ADP/ATP carriers in muscle function and pathophysiology of human myopathies. Adenosine Diphosphate 127-130 solute carrier family 25 member 4 Homo sapiens 45-49 22740917-8 2012 When mice were administered plasmid coding ADP (pDNA-ADP) to generate an immune response to ADP prior to therapy, transfection of the ADP gene induced a much higher level of tumor growth suppression than that found in the non-immunized mice. Adenosine Diphosphate 43-46 WD and tetratricopeptide repeats 1 Mus musculus 48-56 22740917-9 2012 An evident synergistic effect of ADP and GM-CSF genes was also observed, and at a pDNA-ADP/pDNA-GM-CSF ratio of 4:1, significant suppression of tumor growth was achieved even in the non-immunized mice. Adenosine Diphosphate 33-36 WD and tetratricopeptide repeats 1 Mus musculus 82-90 22052482-9 2012 Mammalian GDH exhibits negative cooperativity with respect to binding of NAD and NADPH coenzyme molecules, activation by ADP, and inhibition by GTP. Adenosine Diphosphate 82-85 glutamate dehydrogenase 1 Homo sapiens 10-13 32445636-2 2020 NPP4 on the surface of endothelial cells was reported to promote platelet aggregation by hydrolyzing Ap3A to ADP, which activates pro-thrombotic G protein-coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 109-112 purinergic receptor P2Y1 Homo sapiens 163-167 32428354-15 2020 Functional analysis displayed higher P-selectin expression as compared to non-RP upon ADP- or TRAP- stimulation. Adenosine Diphosphate 86-89 selectin P Homo sapiens 37-47 22916275-1 2012 Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Adenosine Diphosphate 0-21 purinergic receptor P2Y1 Homo sapiens 143-149 32843840-8 2020 Based on the primary and secondary protein structures, we propose that MMP0253 may function as the adenosine diphosphate (ADP)-forming acetyl-CoA synthetase to catalyse acetate formation from acetyl-CoA. Adenosine Diphosphate 122-125 acetate--CoA ligase family protein Methanococcus maripaludis S2 71-78 22916275-1 2012 Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors, the P2Y(1) and P2Y(12) purinoceptors. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 143-149 22829870-6 2012 By contrast, silencing of the mitochondrial Na(+)-Ca(2+) exchanger NCLX affected the kinetics of glucose-induced changes in, but not steady state values of, cytosolic ATP/ADP. Adenosine Diphosphate 171-174 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 Mus musculus 67-71 22848454-3 2012 Gating of murine P2X7 can be induced by the soluble ligand ATP, as well as by NAD(+)-dependent ADP-ribosylation of arginine 125, a posttranslational protein modification catalyzed by the toxin-related ecto-enzymes ART2.1 and ART2.2. Adenosine Diphosphate 95-98 ADP-ribosyltransferase 2b Mus musculus 225-231 22841838-4 2012 The acto/myosin interaction, by producing changes in ATP, ADP, Pi, and force on a millisecond timescale, may be regarded as a novel and previously unappreciated mechanosensory mechanism. Adenosine Diphosphate 58-61 myosin heavy chain 14 Homo sapiens 9-15 22057269-5 2011 OGG1 stimulated the poly(ADP-ribosyl)ation activity of PARP-1, whereas decreased poly(ADP-ribose) levels were observed in OGG1(-/-) cells compared with wild-type cells in response to DNA damage. Adenosine Diphosphate 25-28 8-oxoguanine DNA glycosylase Homo sapiens 0-4 21998208-1 2011 Extracellular adenosine (ADO), generated from ATP or ADP through the concerted action of the ectoenzymes CD39 and CD73, elicits autocrine and paracrine effects mediated by type 1 purinergic receptors. Adenosine Diphosphate 53-56 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 105-109 21998208-5 2011 CD39(+)/CD73(+) CLL cells generate ADO from ADP in a time- and concentration-dependent manner. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 21641039-3 2011 The ART2.2 catalyzed ADP-ribosylation of cell surface proteins induces cell death. Adenosine Diphosphate 21-24 ADP-ribosyltransferase 2b Mus musculus 4-10 21600947-5 2011 Moreover, GDH is allosterically regulated by GTP and ADP. Adenosine Diphosphate 53-56 glutamate dehydrogenase 1 Homo sapiens 10-13 21680742-6 2011 S1(A261T) is less active (reduced ATPase, higher ADP affinity for S1 and actomyosin subfragment 1 (actin S1), and reduced ATP-induced dissociation of actin S1), whereas S1(G200D) shows increased enzymatic activity (enhanced ATPase, reduced ADP affinity for both S1 and actin S1). Adenosine Diphosphate 49-52 Regulatory particle non-ATPase 2 Drosophila melanogaster 66-97 21642242-10 2011 While no differences in the increase in MPA and CD41 expression were observed after EST-1 and EST-2, ADP stimulation after EST-2 induced a lower increase in MPA (+18.3+-8.1% vs +27.9+-9.7%, p<0.001) and CD41 (+18.3+-9.2% vs +27.2+-12.4%, p<0.001) than after EST-1. Adenosine Diphosphate 101-104 telomerase reverse transcriptase Homo sapiens 123-128 21642242-10 2011 While no differences in the increase in MPA and CD41 expression were observed after EST-1 and EST-2, ADP stimulation after EST-2 induced a lower increase in MPA (+18.3+-8.1% vs +27.9+-9.7%, p<0.001) and CD41 (+18.3+-9.2% vs +27.2+-12.4%, p<0.001) than after EST-1. Adenosine Diphosphate 101-104 sulfotransferase family 1E member 1 Homo sapiens 264-269 32728477-10 2020 ANT1 is a mitochondrial protein, which has a dual functionality, as it is involved both in metabolism via the regulation of ATP/ADP release from mitochondria and in regulated cell death as part of the mitochondrial permeability transition pore. Adenosine Diphosphate 128-131 solute carrier family 25 member 4 Homo sapiens 0-4 32658182-10 2020 The biochemical parameters of cMLCK for MLC2v were determined by a Michaelis-Menten plot using the bioluminescent ADP detection assay. Adenosine Diphosphate 114-117 myosin light chain 2 Homo sapiens 40-45 32390228-2 2020 Here, we use heterologous expression and whole-cell electrophysiology to investigate the regulation of the CLC isoforms ClC-3, ClC-4, and ClC-5 by the adenylic system components ATP, ADP, and AMP. Adenosine Diphosphate 183-186 chloride voltage-gated channel 3 Homo sapiens 120-125 32390228-2 2020 Here, we use heterologous expression and whole-cell electrophysiology to investigate the regulation of the CLC isoforms ClC-3, ClC-4, and ClC-5 by the adenylic system components ATP, ADP, and AMP. Adenosine Diphosphate 183-186 chloride voltage-gated channel 4 Homo sapiens 127-132 32143825-7 2020 Inhibition of the ANT activity with ADP or bongkrekic acid prevented the MMP alteration and potential drop upon CSE exposure. Adenosine Diphosphate 36-39 solute carrier family 25 member 6 Homo sapiens 18-21 32303740-8 2020 Plasmids encoding ATF3 and its siRNA were used to investigate the role of ATF3 on ADP-induced P2X3 upregulation. Adenosine Diphosphate 82-85 purinergic receptor P2X 3 Rattus norvegicus 94-98 32303740-10 2020 SP600125, an inhibitor of c-JUN N-terminal kinase, was wrapped in CSOSA/LPs delivery system and its inhibitory effects on ADP-induced upregulation of P2X3 in DRG cells and endometriosis-induced hyperalgesia in rats were tested. Adenosine Diphosphate 122-125 purinergic receptor P2X 3 Rattus norvegicus 150-154 32303740-12 2020 In DRG cells, P2X3 expression levels were elevated by ADP stimulation, but dramatically inhibited by blocking ATF3 with its siRNA and SP600125. Adenosine Diphosphate 54-57 purinergic receptor P2X 3 Rattus norvegicus 14-18 32303740-13 2020 CHIP and luciferase assay showed that ADP increased the binding of ATF3 to the P2X3 promoter, resulting in an increase in P2X3 expression levels. Adenosine Diphosphate 38-41 purinergic receptor P2X 3 Rattus norvegicus 79-83 32303740-13 2020 CHIP and luciferase assay showed that ADP increased the binding of ATF3 to the P2X3 promoter, resulting in an increase in P2X3 expression levels. Adenosine Diphosphate 38-41 purinergic receptor P2X 3 Rattus norvegicus 122-126 32369849-12 2020 In contrast, biochemical agonists ADP, TRAP-6, arachidonic acid, and thrombin were potent inducers of alphaIIbbeta3 activation and/or P-selectin exposure. Adenosine Diphosphate 34-37 selectin P Homo sapiens 134-144 21586654-0 2011 adPEO mutations in ANT1 impair ADP-ATP translocation in muscle mitochondria. Adenosine Diphosphate 31-34 solute carrier family 25 member 4 Homo sapiens 19-23 21586654-6 2011 We demonstrate, for the first time in these disease-relevant mammalian cells, that mutant human ANT1 causes dominant mitochondrial defects characterized by decreased ADP-ATP exchange function and abnormal translocator reversal potential. Adenosine Diphosphate 166-169 solute carrier family 25 member 4 Homo sapiens 96-100 21641214-2 2011 It is involved in the conversion of NAD(P)(+) into cyclic ADP-ribose, NAADP(+) and ADP-ribose and the role of these metabolites in multiple Ca(2+) signaling pathways makes CD38 a novel potential pharmacological target. Adenosine Diphosphate 58-61 CD38 molecule Homo sapiens 172-176 32264868-0 2020 Sodium-glucose cotransporter 2 inhibitors antagonize lipotoxicity in human myeloid angiogenic cells and ADP-dependent activation in human platelets: potential relevance to prevention of cardiovascular events. Adenosine Diphosphate 104-107 solute carrier family 5 member 2 Homo sapiens 0-30 32210919-4 2020 Activating fatty acids overcome constitutive inhibition of UCP1 by the di- and triphosphate forms of purine nucleotides, i.e., ATP, ADP, GTP, and GDP. Adenosine Diphosphate 132-135 uncoupling protein 1 Homo sapiens 59-63 21536675-0 2011 Switch I closure simultaneously promotes strong binding to actin and ADP in smooth muscle myosin. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 90-96 21536675-4 2011 Smooth muscle myosin has displayed the ability to simultaneously bind tightly to both actin and ADP, although it is unclear how both substrate-binding clefts could be closed if they are rigidly coupled to switch I. Adenosine Diphosphate 96-99 myosin heavy chain 14 Homo sapiens 14-20 21536675-5 2011 Here we use single tryptophan mutants of smooth muscle myosin to determine how conformational changes in switch I are correlated with structural changes in the nucleotide and actin-binding clefts in the presence of actin and ADP. Adenosine Diphosphate 225-228 myosin heavy chain 14 Homo sapiens 55-61 32143698-4 2020 GDH is a mitochondrial enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate, under allosteric regulations mediated by its inhibitor GTP and its activator ADP. Adenosine Diphosphate 185-188 glutamate dehydrogenase 1 Homo sapiens 0-3 21346239-4 2011 Manipulation of the pH enabled us to probe rebinding of P(i) to myosin"s ADP-bound state, while changing the ATP concentration probed rebinding to the rigor state. Adenosine Diphosphate 73-76 myosin heavy chain 14 Homo sapiens 64-70 21346239-10 2011 These findings suggest that P(i) differentially affects myosin function: enhancing velocity, if it rebinds to the ADP-bound state, while slowing velocity, if it binds to the rigor state. Adenosine Diphosphate 114-117 myosin heavy chain 14 Homo sapiens 56-62 32143698-8 2020 Enzymatic activity measured in patient-derived lymphoblastoid cells showed impaired allosteric responses of GDH-G446V to both regulators GTP and ADP. Adenosine Diphosphate 145-148 glutamate dehydrogenase 1 Homo sapiens 108-111 31838041-8 2020 The released levels of phosphorylated-HSP27 was correlated with the levels of phosphorylated-HSP27 stimulated by ADP or collagen. Adenosine Diphosphate 113-116 heat shock protein family B (small) member 1 Homo sapiens 38-43 20950584-1 2011 Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. Adenosine Diphosphate 95-98 solute carrier family 25 member 6 Homo sapiens 0-30 20950584-1 2011 Adenine nucleotide translocase (ANT), a mitochondrial protein that facilitates the exchange of ADP and ATP across the mitochondrial inner membrane, plays an essential role in cellular energy metabolism. Adenosine Diphosphate 95-98 solute carrier family 25 member 6 Homo sapiens 32-35 20950584-4 2011 ANT1 and ANT3 export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP. Adenosine Diphosphate 131-134 solute carrier family 25 member 4 Homo sapiens 0-4 20950584-4 2011 ANT1 and ANT3 export the ATP produced by oxidative phosphorylation (OxPhos) from the mitochondria into the cytosol while importing ADP. Adenosine Diphosphate 131-134 solute carrier family 25 member 6 Homo sapiens 9-13 21419344-3 2011 We report crystal structures of Upf1 in the presence and absence of the CH domain, captured in the transition state with ADP:AlF4- and RNA. Adenosine Diphosphate 121-124 UPF1 RNA helicase and ATPase Homo sapiens 32-36 31838041-8 2020 The released levels of phosphorylated-HSP27 was correlated with the levels of phosphorylated-HSP27 stimulated by ADP or collagen. Adenosine Diphosphate 113-116 heat shock protein family B (small) member 1 Homo sapiens 93-98 31838041-9 2020 The levels of ADP-induced phosphorylated-HSP27 were correlated with those of both phosphorylated-protein kinase B (Akt) and phosphorylatd-p38 mitogen-activated protein kinase; however, the levels of phosphorylated-HSP27 stimulated by collagen were correlated with phosphorylated-Akt levels only. Adenosine Diphosphate 14-17 heat shock protein family B (small) member 1 Homo sapiens 41-46 21245745-5 2011 CD62P expression was detected by flow cytometry in normal and 5 mumol/l ADP-activated platelets. Adenosine Diphosphate 72-75 selectin P Homo sapiens 0-5 31838041-9 2020 The levels of ADP-induced phosphorylated-HSP27 were correlated with those of both phosphorylated-protein kinase B (Akt) and phosphorylatd-p38 mitogen-activated protein kinase; however, the levels of phosphorylated-HSP27 stimulated by collagen were correlated with phosphorylated-Akt levels only. Adenosine Diphosphate 14-17 heat shock protein family B (small) member 1 Homo sapiens 214-219 31838041-10 2020 The ED50 value of ADP on the platelet aggregation in OSAS (1.067 +- 0.128 muM) was lower than that in healthy subjects (1.778 +- 0.122 muM) and was inversely correlated with both the value of minimum SpO2 and the released level of phosphorylated-HSP27 stimulated by ADP. Adenosine Diphosphate 18-21 heat shock protein family B (small) member 1 Homo sapiens 246-251 31549730-9 2020 Both IL-1beta and IL-6 responses were augmented by extracellular ADP or ADP-betaS and were abrogated by PSB0739. Adenosine Diphosphate 65-68 interleukin 1 alpha Homo sapiens 5-13 31931718-11 2020 In addition, SAA decreased the expressions of PAC-1 and CD62p, which were enhanced by ADP and thrombin (all P < 0.01). Adenosine Diphosphate 86-89 selectin P Homo sapiens 56-61 31610608-9 2020 Using cell-based assays revealed that C. rodentium activates the ALPK1/TIFA axis, which is dependent on the ADP-heptose biosynthesis pathway, but independent of the type III secretion system (T3SS). Adenosine Diphosphate 108-111 alpha-kinase 1 Mus musculus 65-70 31652269-4 2019 The two main enzymes responsible for generating adenosine in the microenvironment are the ectonucleotidases CD39 and CD73, the former utilizes both ATP and ADP and produces AMP while the latter utilizes AMP and generates adenosine. Adenosine Diphosphate 156-159 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 108-112 31548257-3 2019 Here we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean within two highly conserved nitrate-induced (NOI) domains. Adenosine Diphosphate 34-37 RPM1 interacting protein 4 Arabidopsis thaliana 54-58 31548257-5 2019 The ADP-ribosylation activity of AvrRpm1 is required for subsequent phosphorylation on threonine 166 of Arabidopsis RIN4, an event that is necessary and sufficient for RPM1 activation. Adenosine Diphosphate 4-7 RPM1 interacting protein 4 Arabidopsis thaliana 116-120 31510016-2 2019 We have previously described a novel pathway in breast cancer cells, whereby ADP (Adenosine diphosphate)-ribose derived from hydrolysis of poly (ADP-Ribose) and pyrophosphate (PPi) are converted to ATP, catalysed by the enzyme NUDT5 (nucleotide diphosphate hydrolase type 5). Adenosine Diphosphate 77-80 nudix hydrolase 5 Homo sapiens 227-232 31510016-2 2019 We have previously described a novel pathway in breast cancer cells, whereby ADP (Adenosine diphosphate)-ribose derived from hydrolysis of poly (ADP-Ribose) and pyrophosphate (PPi) are converted to ATP, catalysed by the enzyme NUDT5 (nucleotide diphosphate hydrolase type 5). Adenosine Diphosphate 77-80 nudix hydrolase 5 Homo sapiens 234-273 31510016-2 2019 We have previously described a novel pathway in breast cancer cells, whereby ADP (Adenosine diphosphate)-ribose derived from hydrolysis of poly (ADP-Ribose) and pyrophosphate (PPi) are converted to ATP, catalysed by the enzyme NUDT5 (nucleotide diphosphate hydrolase type 5). Adenosine Diphosphate 82-103 nudix hydrolase 5 Homo sapiens 227-232 31510016-2 2019 We have previously described a novel pathway in breast cancer cells, whereby ADP (Adenosine diphosphate)-ribose derived from hydrolysis of poly (ADP-Ribose) and pyrophosphate (PPi) are converted to ATP, catalysed by the enzyme NUDT5 (nucleotide diphosphate hydrolase type 5). Adenosine Diphosphate 82-103 nudix hydrolase 5 Homo sapiens 234-273 31265325-8 2019 Furthermore, lack of PGC-1alpha was associated with altered phosphorylation and carbonylation of the inner mitochondrial membrane ADP/ATP exchanger adenine nucleotide translocase 1. Adenosine Diphosphate 130-133 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 148-180 28403626-7 2019 RESULTS: In vitro, pegnivacogin significantly reduced adenosine diphosphate-induced CD62P-expression (100% vs. 89.79+-4.04%, p=0.027, n=9) and PAC-1 binding (100% vs. 83.02+-4.08%, p=0.010, n=11). Adenosine Diphosphate 54-75 selectin P Homo sapiens 84-89 30225759-2 2019 We investigated the involvement of adenine nucleotide translocase 2 (ANT2), which catalyzes ADP/ATP exchange at the mitochondrial inner membrane, in [18F] FDG accumulation. Adenosine Diphosphate 92-95 solute carrier family 25 member 6 Homo sapiens 35-67 30225759-2 2019 We investigated the involvement of adenine nucleotide translocase 2 (ANT2), which catalyzes ADP/ATP exchange at the mitochondrial inner membrane, in [18F] FDG accumulation. Adenosine Diphosphate 92-95 solute carrier family 25 member 6 Homo sapiens 69-73 31075617-5 2019 RT-PCR and FACS analyses served to characterize ADP degrading ectonucleoside triphosphate diphosphohydrolase-1 (ectoNTPDase-1/CD39) expression on various cell types. Adenosine Diphosphate 48-51 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 62-110 31075617-5 2019 RT-PCR and FACS analyses served to characterize ADP degrading ectonucleoside triphosphate diphosphohydrolase-1 (ectoNTPDase-1/CD39) expression on various cell types. Adenosine Diphosphate 48-51 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 126-130 30995725-9 2019 Altered structural conformations were also visible within various regions of Eg5, including switch I, switch II, alpha2/alpha3 helices, and the tubulin-binding region, indicating that MF might induce modifications in the Eg5 structure to compromise its ATP/ADP binding and conversion process as well as its interaction with microtubules. Adenosine Diphosphate 257-260 kinesin family member 11 Homo sapiens 221-224 30848916-8 2019 IFN-gamma increased the ADP-ribosylation status of ARTD9/PARP9, ARTD8/PARP14, and proteins involved in RNA processes. Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase family member 9 Homo sapiens 51-56 30848916-8 2019 IFN-gamma increased the ADP-ribosylation status of ARTD9/PARP9, ARTD8/PARP14, and proteins involved in RNA processes. Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase family member 9 Homo sapiens 57-62 30916503-8 2019 Preterm cord blood platelets showed decreased ADP-induced activation in both activation markers: PAC1 and p-selectin, but only p-selectin reached statistical significance. Adenosine Diphosphate 46-49 selectin P Homo sapiens 106-116 21185839-8 2011 In excised inside-out patches, HMR 1098 inhibited Kir6.2/SUR1 channels more effectively, particularly in the presence of MgADP and MgATP (mimicking physiological stimulation). Adenosine Diphosphate 121-126 potassium inwardly rectifying channel, subfamily J, member 11 Mus musculus 50-56 30529103-4 2019 In the absence of F-actin, myosin S1 with Mg2+ bound to a fluorescent ADP analog about five-times tighter than without Mg2+. Adenosine Diphosphate 70-73 myosin heavy chain 14 Homo sapiens 27-33 21136013-1 2011 We have recently shown that ADP-induced activation of protein kinase C (PKC) requires the co-stimulation of both P2Y1 and P2Y12 receptors. Adenosine Diphosphate 28-31 purinergic receptor P2Y1 Homo sapiens 113-117 21148312-10 2011 These data provide further understanding of the mechanisms that regulate endogenous ADP-ribosylation of the Gbeta subunit, and they demonstrate a novel role for Arf6 in hormone regulation of Gbeta subunit mono-ADP-ribosylation. Adenosine Diphosphate 84-87 ADP ribosylation factor 6 Homo sapiens 161-165 21076465-3 2011 On the one hand, ANT catalyzes the adenosine triphosphate export from the mitochondrial matrix to the intermembrane space with the concomitant import of ADP from the intermembrane space to the matrix. Adenosine Diphosphate 153-156 solute carrier family 25 member 6 Homo sapiens 17-20 30529103-5 2019 In the presence of F-actin, the affinity of myosin S1 toward the ADP analog significantly decreased both with and without Mg2+. Adenosine Diphosphate 65-68 myosin heavy chain 14 Homo sapiens 44-50 30529103-6 2019 The equilibrium titration of myosin-S1 into F-actin revealed that in the presence of ADP the apparent dissociation constant (Kd) without Mg2+ was more than five-fold smaller than with Mg2+. Adenosine Diphosphate 85-88 myosin heavy chain 14 Homo sapiens 29-35 30659162-0 2019 Correction: Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. Adenosine Diphosphate 97-100 ADP-ribosylserine hydrolase Homo sapiens 68-72 20863624-8 2011 Platelet reactivity was higher in war veterans with PTSD when compared to controls, as determined by greater CD62P expression and formation of PLA in response to ADP alone or in combination with EPI. Adenosine Diphosphate 162-165 selectin P Homo sapiens 109-114 30745807-8 2019 CD42+/CD62P+ PMVs numbers correlated positively to the ADP-induced aggregation on clopidogrel (p<0.01) or prasugrel (p<0.05), which was absent in ticagrelor users (p=0.8). Adenosine Diphosphate 55-58 selectin P Homo sapiens 6-11 21319374-6 2011 CONCLUSION: BaP can stimulate ADP-induced platelet aggregation and P-selectin expression, probably through the interaction with ADP-mediated signal pathway. Adenosine Diphosphate 128-131 selectin P Homo sapiens 67-77 31450503-6 2019 RESULTS: AD patients showed significantly lower aggregation response to ADP and arachidonic acid and significantly decreased CD62P and CD63 surface expression induced by ADP and U46619 compared to HC. Adenosine Diphosphate 170-173 selectin P Homo sapiens 125-130 21124851-5 2010 These site has evolved from the phosphoenolpyruvate/ADP binding site of bacterial PFK1 due to the processes of duplication and tandem fusion of prokaryotic ancestor gene followed by the divergence of the catalytic and effector binding sites. Adenosine Diphosphate 52-55 phosphofructokinase, muscle Homo sapiens 82-86 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 51-54 poly(ADP-ribose) polymerase family member 9 Homo sapiens 165-170 20968292-5 2010 These peptides are recognized as substrates by the ADP-ribosylation biochemical machinery (PARP1), can interact with the ADP-ribose binding proteins macroH2A1.1 and PARP9, and demonstrate superior enzymatic and chemical stability when compared to ester-linked ADP-ribose. Adenosine Diphosphate 121-124 poly(ADP-ribose) polymerase family member 9 Homo sapiens 165-170 21103408-3 2010 Here we show that upregulation of Ca(v)2.3 R-type calcium channels is responsible for a component of the ADP lasting several hundred milliseconds. Adenosine Diphosphate 105-108 calcium voltage-gated channel subunit alpha1 E Homo sapiens 34-42 20952684-0 2010 Role of the P2Y12 receptor in the modulation of murine dendritic cell function by ADP. Adenosine Diphosphate 82-85 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 12-17 20960209-6 2010 ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide). Adenosine Diphosphate 0-3 signal transducer and activator of transcription 3 Rattus norvegicus 114-119 20960209-6 2010 ADP-stimulated respiration was reduced in mitochondria from mice with a cardiomyocyte-specific deletion of STAT3 (STAT3-KO) versus wildtypes and in rat mitochondria treated with the STAT3 inhibitor Stattic (STAT3 inhibitory compound, 6-Nitrobenzo[b]thiophene 1,1-dioxide). Adenosine Diphosphate 0-3 signal transducer and activator of transcription 3 Rattus norvegicus 114-119 20977463-2 2010 Concentrations of nucleotides such as ADP, the physiological agonist at platelet P2Y1 and P2Y12 receptors, are regulated by vascular ectonucleotidases, mainly nucleoside triphosphate diphosphohydrolase (NTPDase)1 and ecto-5"-nucleotidase. Adenosine Diphosphate 38-41 purinergic receptor P2Y1 Homo sapiens 81-85 20977463-2 2010 Concentrations of nucleotides such as ADP, the physiological agonist at platelet P2Y1 and P2Y12 receptors, are regulated by vascular ectonucleotidases, mainly nucleoside triphosphate diphosphohydrolase (NTPDase)1 and ecto-5"-nucleotidase. Adenosine Diphosphate 38-41 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 203-212 20591842-9 2010 Platelet activation was also increased by transfusion as confirmed by an elevation of P-selectin expression induced by 20 microM ADP (12.2 +- 18 vs. 23.9 +- 18%; P = 0.002) or 50 microM ADP (15.4 +- 18.6 vs.26.8 +- 21.2%; P = 0.004) and an increase in VASP PRI (77.8 +- 6 vs. 81.9 +- 3%; P = 0.03). Adenosine Diphosphate 129-132 selectin P Homo sapiens 86-96 20591842-9 2010 Platelet activation was also increased by transfusion as confirmed by an elevation of P-selectin expression induced by 20 microM ADP (12.2 +- 18 vs. 23.9 +- 18%; P = 0.002) or 50 microM ADP (15.4 +- 18.6 vs.26.8 +- 21.2%; P = 0.004) and an increase in VASP PRI (77.8 +- 6 vs. 81.9 +- 3%; P = 0.03). Adenosine Diphosphate 186-189 selectin P Homo sapiens 86-96 20697932-5 2010 The response of GDH to allosteric activators in the presence of NAD(H) and NADP(H) suggests that ADP and leucine moderate much of the inhibitory effect of NADP(H) on the utilization of NAD(H). Adenosine Diphosphate 76-79 glutamate dehydrogenase 1 Homo sapiens 16-19 20930120-3 2010 P2ry12(+/-) mouse platelets showed partially decreased responses to ADP, resembling those in clopidogrel-treated human platelets. Adenosine Diphosphate 68-71 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 0-6 20594939-1 2010 The ADP-activated P2Y(1) receptor is broadly expressed and plays a crucial role in ADP-promoted platelet aggregation. Adenosine Diphosphate 4-7 purinergic receptor P2Y1 Homo sapiens 18-33 20952347-9 2010 Furthermore we saw a significant decrease in platelet function in the HES 200/0.5 group when performing the multiplate-analysis (ADP-and COL-test). Adenosine Diphosphate 129-132 ribosome binding protein 1 Homo sapiens 70-73 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 0-21 selectin P Homo sapiens 69-79 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 23-26 selectin P Homo sapiens 69-79 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 43-46 selectin P Homo sapiens 69-79 20823666-8 2010 Either SZ-21 or aspirin can inhibit the ADP-induced expression of P-selectin and GPIIb/IIIa. Adenosine Diphosphate 40-43 selectin P Homo sapiens 66-76 20689986-5 2010 The release of EDRF from the endothelium can be mediated by both pertussis toxin-sensitive G(i) (alpha(2)-adrenergic activation, serotonin, thrombin) and insensitive G(q) (adenosine diphosphate, bradykinin) coupling proteins. Adenosine Diphosphate 172-193 alpha hemoglobin stabilizing protein Homo sapiens 15-19 20664064-3 2010 Whereas macrophages from mice deficient in pannexin-1 (which is part of a putative ATP release pathway), P2Y(2), or P2Y(12) exhibited efficient chemotactic navigation, chemotaxis was blocked by apyrase, which degrades ATP and ADP, and by the inhibition of multiple purinergic receptors. Adenosine Diphosphate 226-229 pannexin 1 Mus musculus 43-53 19176251-0 2010 The reversible oral P2Y12 antagonist AZD6140 inhibits ADP-induced contractions in murine and human vasculature. Adenosine Diphosphate 54-57 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 20-25 20528917-5 2010 We demonstrated that cell death induced by ANT1 depletion cannot be ascribed to the loss of the ATP/ADP exchange function of this protein. Adenosine Diphosphate 100-103 solute carrier family 25 member 4 Homo sapiens 43-47 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 111-114 solute carrier family 25 member 4 Homo sapiens 274-278 20513406-7 2010 In particular, EPR probes attached to the neck linker of MT-bound Eg5 shifted to a more immobilized component in the nucleotide-free state relative to the ADP-bound state, consistent with the neck linker docking upon ADP release. Adenosine Diphosphate 155-158 kinesin family member 11 Homo sapiens 66-69 20513406-7 2010 In particular, EPR probes attached to the neck linker of MT-bound Eg5 shifted to a more immobilized component in the nucleotide-free state relative to the ADP-bound state, consistent with the neck linker docking upon ADP release. Adenosine Diphosphate 217-220 kinesin family member 11 Homo sapiens 66-69 20154092-5 2010 Simultaneous examination of conformational switching in Eg5, in parallel with catalytic steps, shows structural transitions in solution consistent with published crystal structures of the prehydrolytic and ADP-bound states. Adenosine Diphosphate 206-209 kinesin family member 11 Homo sapiens 56-59 20371323-6 2010 This accords with the idea that attached myosin heads in the AM( *)ADP state position the partner heads for rapid attachment to the next site along actin, corresponding to the apparent increase in attachment rate in the model. Adenosine Diphosphate 67-70 myosin heavy chain 14 Homo sapiens 41-47 19945439-5 2010 PARP activity in the renal cortex was assessed by Western blot analysis of poly(ADP-ribosyl)ated proteins. Adenosine Diphosphate 80-83 poly (ADP-ribose) polymerase 1 Rattus norvegicus 0-4 31450503-6 2019 RESULTS: AD patients showed significantly lower aggregation response to ADP and arachidonic acid and significantly decreased CD62P and CD63 surface expression induced by ADP and U46619 compared to HC. Adenosine Diphosphate 170-173 CD63 molecule Homo sapiens 135-139 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 0-21 selectin P Homo sapiens 111-121 19703819-3 2010 Adenosine diphosphate (ADP)-induced platelet aggregation and the expressions of glycoprotein (Gp) IIb, GpIIIa, P-selectin, and fibrinogen (Fg) and low-density lipoprotein (LDL) binding to platelets were assessed preoperatively and at postoperative days 7, 90, and 180. Adenosine Diphosphate 23-26 selectin P Homo sapiens 111-121 30204045-8 2019 A proper inverse correlation was observed between ADP-induced LTA and spontaneous platelet activation assessed by CD62P expression (r = -0.61, p < 0.0001). Adenosine Diphosphate 50-53 selectin P Homo sapiens 114-119 20960266-3 2010 In order to investigate the relationship between hyperprolactinemia and platelet activation evidenced by ADP-stimulated P-selectin expression on flow cytometry, we studied hyperprolactinemic, macroprolactinemic, and normoprolactinemic subjects. Adenosine Diphosphate 105-108 selectin P Homo sapiens 120-130 30204045-14 2019 Spontaneous CD62P and PAC1 expression were significantly greater, and ADP-induced aggregation and agonist-induced increase in CD62P and PAC1 were significantly lower in PPCA compared to APC and PPC on day 4 of storage. Adenosine Diphosphate 70-73 selectin P Homo sapiens 126-131 30472116-7 2018 Despite this apparent similarity, we elucidate the structural basis for the selective inhibition of ARH3 by the ADP-ribose analogues ADP-HPD and arginine-ADP-ribose. Adenosine Diphosphate 112-115 ADP-ribosylserine hydrolase Homo sapiens 100-104 20207994-4 2010 Therefore, we hypothesized that phosphohydrolysis of ATP/ADP via the ectonucleoside triphosphate diphosphohydrolase-1 (CD39), conversion of ATP/ADP to AMP, mediates IP-dependent liver protection. Adenosine Diphosphate 57-60 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 69-117 20207994-4 2010 Therefore, we hypothesized that phosphohydrolysis of ATP/ADP via the ectonucleoside triphosphate diphosphohydrolase-1 (CD39), conversion of ATP/ADP to AMP, mediates IP-dependent liver protection. Adenosine Diphosphate 57-60 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 119-123 20207994-4 2010 Therefore, we hypothesized that phosphohydrolysis of ATP/ADP via the ectonucleoside triphosphate diphosphohydrolase-1 (CD39), conversion of ATP/ADP to AMP, mediates IP-dependent liver protection. Adenosine Diphosphate 144-147 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 69-117 30297535-9 2018 Together, these results establish proof-of-concept antitumor efficacy through PARP6 inhibition and highlight a novel function of PARP6 in maintaining centrosome integrity via direct ADP-ribosylation of Chk1 and modulation of its activity. Adenosine Diphosphate 182-185 poly(ADP-ribose) polymerase family member 6 Homo sapiens 129-134 20097289-5 2010 In cells coexpressing the Galpha(q/11)-coupled hP2Y(1) receptor, ADP and ATP also inhibited hK(2P)2.1 currents, which were abolished by MRS2179, but unaffected by AR-C69931MX and PTX. Adenosine Diphosphate 65-68 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 26-37 20097289-5 2010 In cells coexpressing the Galpha(q/11)-coupled hP2Y(1) receptor, ADP and ATP also inhibited hK(2P)2.1 currents, which were abolished by MRS2179, but unaffected by AR-C69931MX and PTX. Adenosine Diphosphate 65-68 purinergic receptor P2Y1 Homo sapiens 47-63 30088129-12 2018 ADP responses were attenuated by the selective P2Y6 receptor antagonist, MRS2587 (IC50 437 +- 133nM, 81.0 +- 8.4% max inhibition; N = 6 donors). Adenosine Diphosphate 0-3 pyrimidinergic receptor P2Y6 Homo sapiens 47-60 20048161-6 2010 In contrast, ATP, ADP, AMP, PLP, p-nitrophenyl phosphate, and PP(i) were hydrolyzed by TNAP-, NPP1-, and TNAP plus NPP1-containing proteoliposomes. Adenosine Diphosphate 18-21 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus 94-98 20048161-6 2010 In contrast, ATP, ADP, AMP, PLP, p-nitrophenyl phosphate, and PP(i) were hydrolyzed by TNAP-, NPP1-, and TNAP plus NPP1-containing proteoliposomes. Adenosine Diphosphate 18-21 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mus musculus 115-119 30442809-5 2018 Intact mitochondrial membranes from Bos taurus yielded respiratory complexes and fatty acid-bound dimers of the ADP (adenosine diphosphate)/ATP translocase (ANT-1). Adenosine Diphosphate 112-115 solute carrier family 25 member 4 Bos taurus 157-162 20147598-0 2010 Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit. Adenosine Diphosphate 102-105 heat shock protein 90 alpha family class A member 1 Homo sapiens 61-66 20147598-7 2010 The authors have evaluated the use of commercial reagents (Transcreener ADP) for the measurement of ATPase activity of both yeast and human Hsp90 (ATP K(m) approximately 500 microM) and human Hsp72 (ATP K(m) ~1 microM). Adenosine Diphosphate 72-75 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 20124694-0 2010 Structures of human MST3 kinase in complex with adenine, ADP and Mn2+. Adenosine Diphosphate 57-60 serine/threonine kinase 24 Homo sapiens 20-24 20124694-3 2010 Here, five crystal structures of the catalytic domain of MST3 are presented, including a complex with ADP and manganese, a unique cofactor preferred by the enzyme, and a complex with adenine. Adenosine Diphosphate 102-105 serine/threonine kinase 24 Homo sapiens 57-61 30442809-5 2018 Intact mitochondrial membranes from Bos taurus yielded respiratory complexes and fatty acid-bound dimers of the ADP (adenosine diphosphate)/ATP translocase (ANT-1). Adenosine Diphosphate 117-138 solute carrier family 25 member 4 Bos taurus 157-162 30392930-5 2018 CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis. Adenosine Diphosphate 25-28 phosphoglycerate kinase 1 Homo sapiens 11-15 30392930-5 2018 CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis. Adenosine Diphosphate 81-84 phosphoglycerate kinase 1 Homo sapiens 11-15 19915796-4 2010 Adding the ADP analogue, 2MeSADP, to MIN6c4 cells induced calcium influx/mobilization and inhibition of cAMP production by activation of P2Y(1) and P2Y(13), respectively. Adenosine Diphosphate 11-14 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 137-143 19915796-4 2010 Adding the ADP analogue, 2MeSADP, to MIN6c4 cells induced calcium influx/mobilization and inhibition of cAMP production by activation of P2Y(1) and P2Y(13), respectively. Adenosine Diphosphate 11-14 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 148-155 29984433-3 2018 Using real-time PCR, we showed that activation of the P2Y1 receptor by ADP increased the expression of MMP2/9 mRNAs; MMP2/9 collected from conditioned media also showed an increase in activity; and ADP induced the nuclear localization of MMP2/9. Adenosine Diphosphate 71-74 purinergic receptor P2Y1 Homo sapiens 54-67 19915796-7 2010 These results indicate that P2Y(13) is a proapoptotic receptor in beta-cells as the P2Y(13) receptor antagonist MRS2211 is able to protect the cells from ADP induced apoptosis. Adenosine Diphosphate 154-157 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 28-35 19915796-7 2010 These results indicate that P2Y(13) is a proapoptotic receptor in beta-cells as the P2Y(13) receptor antagonist MRS2211 is able to protect the cells from ADP induced apoptosis. Adenosine Diphosphate 154-157 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 84-91 29984433-3 2018 Using real-time PCR, we showed that activation of the P2Y1 receptor by ADP increased the expression of MMP2/9 mRNAs; MMP2/9 collected from conditioned media also showed an increase in activity; and ADP induced the nuclear localization of MMP2/9. Adenosine Diphosphate 198-201 purinergic receptor P2Y1 Homo sapiens 54-67 30392073-0 2018 Using steered molecular dynamics to study the interaction between ADP and the nucleotide-binding domain of yeast Hsp70 protein Ssa1. Adenosine Diphosphate 66-69 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 127-131 19618221-4 2010 Furthermore, a twofold increase in the expression of ANT led to the reduced efficiency of oxidative phosphorylation in CMT2A cells, suggesting that MFN2 plays a role in controlling ATP/ADP exchanges. Adenosine Diphosphate 185-188 solute carrier family 25 member 6 Homo sapiens 53-56 30392073-8 2018 Additionally, we identify the primary residues in the ATPase domain that directly constitute the main hydrophobic interaction network and directly influence the ADP interaction state with the NBD of Ssa1. Adenosine Diphosphate 161-164 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 199-203 19945153-4 2010 ADP-stimulated platelet shape change (P2Y(1)-mediated) and aggregation (P2Y(1)- and P2Y(12)-mediated) were measured optically. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 38-44 30235277-6 2018 P-selectin expression, a marker of platelet activation, at baseline and in reactivity to stimulation by adenosine diphosphate (ADP), were higher in HbE/ss-thal subjects than normal subjects. Adenosine Diphosphate 104-125 selectin P Homo sapiens 0-10 19945153-4 2010 ADP-stimulated platelet shape change (P2Y(1)-mediated) and aggregation (P2Y(1)- and P2Y(12)-mediated) were measured optically. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 72-78 19945153-5 2010 Ap(4)A inhibited 3 microM ADP-induced: a) platelet aggregation (IC(50) 9.8+/-2.8 microM), b) P2Y(1)-mediated shape change, c) P2Y(1)-mediated increase in platelet cytosolic Ca(2+) (IC(50) 40.8+/-12.3 microM), and d) P2Y(12)-mediated decrease in VASP phosphorylation (IC(50)>250 microM). Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 93-99 30235277-6 2018 P-selectin expression, a marker of platelet activation, at baseline and in reactivity to stimulation by adenosine diphosphate (ADP), were higher in HbE/ss-thal subjects than normal subjects. Adenosine Diphosphate 127-130 selectin P Homo sapiens 0-10 19945153-5 2010 Ap(4)A inhibited 3 microM ADP-induced: a) platelet aggregation (IC(50) 9.8+/-2.8 microM), b) P2Y(1)-mediated shape change, c) P2Y(1)-mediated increase in platelet cytosolic Ca(2+) (IC(50) 40.8+/-12.3 microM), and d) P2Y(12)-mediated decrease in VASP phosphorylation (IC(50)>250 microM). Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 126-132 30235277-8 2018 Nitrite plus deoxygenated erythrocytes from HbE/ss-thal subjects had a lower ability to inhibit ADP-induced P-selectin expression on platelets than erythrocytes from normal subjects. Adenosine Diphosphate 96-99 selectin P Homo sapiens 108-118 30045870-0 2018 Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation. Adenosine Diphosphate 85-88 ADP-ribosylserine hydrolase Homo sapiens 56-60 19858196-7 2010 Sensitivity to ADP activation of GDH1 was unaffected by PMP-BCATm; however, addition of a 3 or higher molar ratio of PMP-BCATm to GDH1 protected GDH1 from GTP inhibition by 50%. Adenosine Diphosphate 15-18 glutamate dehydrogenase 1 Homo sapiens 33-37 19858196-7 2010 Sensitivity to ADP activation of GDH1 was unaffected by PMP-BCATm; however, addition of a 3 or higher molar ratio of PMP-BCATm to GDH1 protected GDH1 from GTP inhibition by 50%. Adenosine Diphosphate 15-18 glutamate dehydrogenase 1 Homo sapiens 130-134 19858196-7 2010 Sensitivity to ADP activation of GDH1 was unaffected by PMP-BCATm; however, addition of a 3 or higher molar ratio of PMP-BCATm to GDH1 protected GDH1 from GTP inhibition by 50%. Adenosine Diphosphate 15-18 glutamate dehydrogenase 1 Homo sapiens 130-134 19350338-2 2010 The spontaneous microaggregates of platelets induced by shear stress were accelerated after the treatment, concomitant with the significant upregulation of p44/p42 mitogen-activated protein (MAP) kinase induced by adenosine diphosphate (ADP). Adenosine Diphosphate 214-235 cyclin dependent kinase 20 Homo sapiens 160-163 30045870-2 2018 Recent evidence suggests that serine is an important acceptor for ADP-ribosylation, and that serine ADP-ribosylation is hydrolyzed by ADP-ribosylhydrolase 3 (ARH3 or ADPRHL2). Adenosine Diphosphate 66-69 ADP-ribosylserine hydrolase Homo sapiens 158-162 19350338-2 2010 The spontaneous microaggregates of platelets induced by shear stress were accelerated after the treatment, concomitant with the significant upregulation of p44/p42 mitogen-activated protein (MAP) kinase induced by adenosine diphosphate (ADP). Adenosine Diphosphate 237-240 cyclin dependent kinase 20 Homo sapiens 160-163 19350338-3 2010 After the cessation of raloxifene, the spontaneous microaggregates of platelets and the acceleration of ADP-induced p44/p42 MAP kinase phosphorylation was diminished. Adenosine Diphosphate 104-107 cyclin dependent kinase 20 Homo sapiens 120-123 19350338-8 2010 RESULTS: The platelet aggregation induced by ADP was little changed; however, low doses (0.3 and 1 microM) of ADP significantly induced the phosphorylation of p44/p42 MAP kinase in the platelets obtained at 12 weeks. Adenosine Diphosphate 110-113 cyclin dependent kinase 20 Homo sapiens 163-166 19350338-11 2010 At 12 weeks after the cessation, the phosphorylation of p44/p42 MAP kinase induced by low doses of ADP was no more observed. Adenosine Diphosphate 99-102 cyclin dependent kinase 20 Homo sapiens 60-63 30045870-2 2018 Recent evidence suggests that serine is an important acceptor for ADP-ribosylation, and that serine ADP-ribosylation is hydrolyzed by ADP-ribosylhydrolase 3 (ARH3 or ADPRHL2). Adenosine Diphosphate 66-69 ADP-ribosylserine hydrolase Homo sapiens 166-173 20822337-6 2010 Furthermore, the ability of several concentrations of ADP to induce surface expression of P-selectin was assessed. Adenosine Diphosphate 54-57 selectin P Homo sapiens 90-100 30045870-9 2018 On the basis of these structural findings, we used site-directed mutagenesis to examine the functional roles of key residues in the catalytic pocket of ARH3 in mediating the hydrolysis of ADP-ribosyl from serine and DNA damage repair. Adenosine Diphosphate 188-191 ADP-ribosylserine hydrolase Homo sapiens 152-156 20822337-9 2010 Furthermore, we found significantly enhanced surface expression of P-selectin in response to different concentrations of ADP in smokers; these differences are even more pronounced in the presence of prostaglandin E1. Adenosine Diphosphate 121-124 selectin P Homo sapiens 67-77 28960117-12 2018 Blockade of the adenosine di-phosphate (ADP) pathway resulted in a further decrease of P-selectin expression, particularly in STAT3 loss-of-function patients. Adenosine Diphosphate 16-38 selectin P Homo sapiens 87-97 21067313-2 2010 We hypothesized that ADP acting through P2Y12 regulates physiological thromboxane levels. Adenosine Diphosphate 21-24 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 40-45 28960117-12 2018 Blockade of the adenosine di-phosphate (ADP) pathway resulted in a further decrease of P-selectin expression, particularly in STAT3 loss-of-function patients. Adenosine Diphosphate 40-43 selectin P Homo sapiens 87-97 28960117-17 2018 GPVI-mediated platelet activation is highly dependent on secondary ADP release. Adenosine Diphosphate 67-70 glycoprotein VI platelet Homo sapiens 0-4 30144157-4 2018 Treatment with ADP did not induce cell apoptosis but instead induced cell cycle arrest in the S phase, which may be partly due to the downregulation of cyclin B1. Adenosine Diphosphate 15-18 cyclin B1 Homo sapiens 152-161 19778616-4 2010 However, enzymatic activity analyses for Rv2613c revealed that Ap4A was converted to ATP and ADP, but not AMP, indicating that Rv2613c has Ap4A phosphorylase activity rather than Ap4A hydrolase activity. Adenosine Diphosphate 93-96 AP-4-A phosphorylase Mycobacterium tuberculosis H37Rv 127-134 19487018-5 2010 Platelet activation by adenosine diphosphate (ADP) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold. Adenosine Diphosphate 23-44 selectin P Homo sapiens 96-101 30144157-5 2018 The inhibition of cell proliferation was blocked by suramin, a nonspecific antagonist of the P2 receptors, and high concentrations of ADP significantly upregulated the messenger RNA (mRNA) and protein expression of P2Y11 in endothelial cells. Adenosine Diphosphate 134-137 purinergic receptor P2Y11 Homo sapiens 215-220 19487018-5 2010 Platelet activation by adenosine diphosphate (ADP) or thrombin agonist peptide (TRAP) increased CD62P and CD40L surface density in the presence of aspirin by 1.9 - 2.8 -fold. Adenosine Diphosphate 46-49 selectin P Homo sapiens 96-101 30144157-8 2018 Taken together, our study excludes a mechanism for extracellular ADP impairing endothelial cells proliferation via P2Y11 receptor by downregulating cyclin B1 and arresting cell cycle at the S phase, besides, ADP induces cell autophagy and mRNA expression of inflammatory cytokines, whether it is mediated by Erk signaling pathways needs further studies to confirm. Adenosine Diphosphate 65-68 purinergic receptor P2Y11 Homo sapiens 115-120 30144157-8 2018 Taken together, our study excludes a mechanism for extracellular ADP impairing endothelial cells proliferation via P2Y11 receptor by downregulating cyclin B1 and arresting cell cycle at the S phase, besides, ADP induces cell autophagy and mRNA expression of inflammatory cytokines, whether it is mediated by Erk signaling pathways needs further studies to confirm. Adenosine Diphosphate 65-68 cyclin B1 Homo sapiens 148-157 19801635-2 2009 Treatment of intact mitochondria with the membrane-permeable bifunctional reagent dimethyl 3,3-dithiobis-propionimidate (DTBP) cross-linked CyPD with the lateral stalk of ATP synthase, whereas no interactions with F(1) sector subunits, the ATP synthase natural inhibitor protein IF1, and the ATP/ADP carrier were observed. Adenosine Diphosphate 296-299 peptidylprolyl isomerase F Bos taurus 140-144 30210708-3 2018 In the present study we investigated the impact of platelet alpha2-adrenoreceptors on ADP-induced platelet aggregation and on ADP-induced platelet membrane CD62P (P-selectin) expression, a marker of platelet activation on blood samples from patients hospitalized at the acute phase of a non cardioembolic ischemic stroke or TIA. Adenosine Diphosphate 126-129 selectin P Homo sapiens 156-161 19815551-3 2009 Phosphoinositide 3-kinase (PI3K) plays an important role in collagen-induced platelet activation, because this activity modulates the autocrine effects of secreted ADP. Adenosine Diphosphate 164-167 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 0-25 30210708-3 2018 In the present study we investigated the impact of platelet alpha2-adrenoreceptors on ADP-induced platelet aggregation and on ADP-induced platelet membrane CD62P (P-selectin) expression, a marker of platelet activation on blood samples from patients hospitalized at the acute phase of a non cardioembolic ischemic stroke or TIA. Adenosine Diphosphate 126-129 selectin P Homo sapiens 163-173 19875982-4 2009 We show a nucleotide-dependent interaction between Hsp70 and alphaSyn, which leads to the aggregation of Hsp70, in the presence of ADP along with alphaSyn. Adenosine Diphosphate 131-134 synuclein alpha Homo sapiens 61-69 30210708-7 2018 Platelet membrane expression of P-selectin was measured by flow cytometry with either ADP alone or combined with epinephrine. Adenosine Diphosphate 86-89 selectin P Homo sapiens 32-42 30210708-8 2018 RESULTS: Epinephrine at low dose stimulated ADP-induced platelet membrane expression of CD62P whereas Atipamezole significantly inhibited 10 microM ADP-induced platelet aggregation. Adenosine Diphosphate 44-47 selectin P Homo sapiens 88-93 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 14-35 purinergic receptor P2Y1 Homo sapiens 141-145 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 14-35 purinergic receptor P2X 1 Homo sapiens 157-161 20059377-5 2009 We determined the performance of the ADP-Glo assay in 1,536-well microtiter plates using the protein kinase Clk4 and a 1,352 member kinase focused combinatorial library. Adenosine Diphosphate 37-40 CDC like kinase 4 Homo sapiens 108-112 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 37-40 purinergic receptor P2Y1 Homo sapiens 141-145 19826421-8 2009 Overexpression of wild-type beta-catenin or a constitutively active beta-catenin mutant mimicked the effect of LTD(4) on ATP/ADP ratio and mtDNA transcription. Adenosine Diphosphate 125-128 catenin beta 1 Homo sapiens 28-40 19826421-8 2009 Overexpression of wild-type beta-catenin or a constitutively active beta-catenin mutant mimicked the effect of LTD(4) on ATP/ADP ratio and mtDNA transcription. Adenosine Diphosphate 125-128 catenin beta 1 Homo sapiens 68-80 19852688-9 2009 Basal and ADP-stimulated CD62P expression and sCD40L level were similar in all groups (p values > 0.05). Adenosine Diphosphate 10-13 selectin P Homo sapiens 25-30 19631364-6 2009 RESULTS: There was a correlation between the ADP-receptor inhibition as measured by VASP-assay and VerifyNowP2Y(12) (r = -0.29, p<0.05), and between VASP-assay and the expression of P-selectin (r = 0.29, p<0.05) as measured by flow cytometry when platelets were stimulated with 5 microM ADP. Adenosine Diphosphate 45-48 selectin P Homo sapiens 185-195 29902630-1 2018 INTRODUCTION: Adenosine diphosphate (ADP) as physiological activator of human platelets mediates its effects via three purinergic receptors: P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 37-40 purinergic receptor P2X 1 Homo sapiens 157-161 30046662-1 2018 Objective: To determine the disease relevance of a novel de novo dominant variant in the SLC25A4 gene, encoding the muscle mitochondrial adenosine diphosphate (ADP)/adenosine triphosphate (ATP) carrier, identified in a child presenting with a previously unreported phenotype of mild childhood-onset myopathy. Adenosine Diphosphate 137-158 solute carrier family 25 member 4 Homo sapiens 89-96 19497292-2 2009 Circular dichroism and isothermal titration calorimetry of our pyrrolotriazine-4-one series of inhibitors with Eg5 motor domain revealed enhanced binding in the presence of adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 173-197 kinesin family member 11 Homo sapiens 111-114 19497292-2 2009 Circular dichroism and isothermal titration calorimetry of our pyrrolotriazine-4-one series of inhibitors with Eg5 motor domain revealed enhanced binding in the presence of adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 199-202 kinesin family member 11 Homo sapiens 111-114 30046662-1 2018 Objective: To determine the disease relevance of a novel de novo dominant variant in the SLC25A4 gene, encoding the muscle mitochondrial adenosine diphosphate (ADP)/adenosine triphosphate (ATP) carrier, identified in a child presenting with a previously unreported phenotype of mild childhood-onset myopathy. Adenosine Diphosphate 160-163 solute carrier family 25 member 4 Homo sapiens 89-96 19497292-5 2009 In general, the inhibitor potency of the pyrrolotriazine-4-one series in in vitro biological assays correlated with the magnitude of the thermal stability enhancement of ADP-Eg5. Adenosine Diphosphate 170-173 kinesin family member 11 Homo sapiens 174-177 30046662-4 2018 Results: Our data demonstrate that the heterozygous c.97A>T (p.Lys33Gln) SLC25A4 variant is associated with classic muscle biopsy findings of mitochondrial myopathy (cytochrome c oxidase [COX]-deficient and ragged blue fibers), significantly impaired ADP/ATP transport in Lactococcus lactis and decreased complex I, III, and IV protein levels in patient"s skeletal muscle. Adenosine Diphosphate 254-257 solute carrier family 25 member 4 Homo sapiens 76-83 29995887-4 2018 Recently, phosphoglycerate kinase 1 (PGK1), an ubiquitous enzyme expressed in all somatic cells that catalyzes the seventh step of glycolysis which consists of the reversible phosphotransfer reaction from 1,3-bisphosphoglycerate to ADP, has been discovered to be overexpressed in many cancer types. Adenosine Diphosphate 232-235 phosphoglycerate kinase 1 Homo sapiens 10-35 19661812-4 2009 In in vitro experiments with human platelets, celastrol inhibits adenosine-5-diphosphate (ADP)-induced expression of the platelet activation marker P-selectin and glycoprotein IIb/IIIa activation with 50% inhibition values of 1.62 and 1.86 microM, respectively. Adenosine Diphosphate 65-88 selectin P Homo sapiens 148-158 19661812-4 2009 In in vitro experiments with human platelets, celastrol inhibits adenosine-5-diphosphate (ADP)-induced expression of the platelet activation marker P-selectin and glycoprotein IIb/IIIa activation with 50% inhibition values of 1.62 and 1.86 microM, respectively. Adenosine Diphosphate 90-93 selectin P Homo sapiens 148-158 29995887-4 2018 Recently, phosphoglycerate kinase 1 (PGK1), an ubiquitous enzyme expressed in all somatic cells that catalyzes the seventh step of glycolysis which consists of the reversible phosphotransfer reaction from 1,3-bisphosphoglycerate to ADP, has been discovered to be overexpressed in many cancer types. Adenosine Diphosphate 232-235 phosphoglycerate kinase 1 Homo sapiens 37-41 19540846-6 2009 An Mcm2 mutant that is defective for ATP hydrolysis (K549A), as well as ATP analogues, was used to show that ADP binding by Mcm2 is required to inhibit DNA binding and unwinding by Mcm4/6/7. Adenosine Diphosphate 109-112 MCM DNA helicase complex subunit MCM2 Saccharomyces cerevisiae S288C 3-7 19540846-6 2009 An Mcm2 mutant that is defective for ATP hydrolysis (K549A), as well as ATP analogues, was used to show that ADP binding by Mcm2 is required to inhibit DNA binding and unwinding by Mcm4/6/7. Adenosine Diphosphate 109-112 MCM DNA helicase complex subunit MCM2 Saccharomyces cerevisiae S288C 124-128 28805478-9 2018 No significant difference was observed in the volume, composition (quantity of platelets, leukocytes and red blood cells) and functionality of platelets from PRP except a higher ADP-induced P-selectin expression in healthy donors compared with elderly patients. Adenosine Diphosphate 178-181 selectin P Homo sapiens 190-200 19540846-6 2009 An Mcm2 mutant that is defective for ATP hydrolysis (K549A), as well as ATP analogues, was used to show that ADP binding by Mcm2 is required to inhibit DNA binding and unwinding by Mcm4/6/7. Adenosine Diphosphate 109-112 MCM DNA helicase complex subunit MCM4 Saccharomyces cerevisiae S288C 181-189 29559479-3 2018 We found that ibrutinib and the novel Btk inhibitors acalabrutinib and ONO/GS-4059 block GPVI-dependent static platelet aggregation in blood exposed to human plaque homogenate and collagen but not to ADP or arachidonic acid. Adenosine Diphosphate 200-203 glycoprotein VI platelet Homo sapiens 89-93 19457106-10 2009 Taken together, we suggest that L-type VGCC in lipid rafts selectively mediates ADP of LDCV exocytosis by regulating PKC-epsilon translocation and MARCKS phosphorylation. Adenosine Diphosphate 80-83 protein kinase C epsilon Homo sapiens 117-128 29942314-1 2018 Objectives: CD39 and CD73 are surface enzymes that jut into the extracellular space where they mediate the step-wise phosphohydrolysis of the autocrine and paracrine danger signals ATP and ADP into anti-inflammatory adenosine. Adenosine Diphosphate 189-192 5' nucleotidase, ecto Mus musculus 21-25 19506755-0 2009 The energetics of allosteric regulation of ADP release from myosin heads. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 60-66 19506755-5 2009 In both examples, a key force-sensing mechanism is the regulation of ADP release via interhead forces that are generated upon actin-myosin binding. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 132-138 19286657-10 2009 Thus, we conclude that ADP activates nPKCeta via P2Y1 receptor and is subsequently dephosphorylated by PP1gamma phosphatase activated by alpha(IIb)beta3 integrin. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 49-62 19228864-6 2009 Greater BMI was associated with higher platelet reactivity in response to 1 microm ADP as assessed by surface expression of P-selectin (r = 0.29, P < 0.0001) but not reflected by the binding of fibrinogen to activated glycoprotein IIb-IIIa. Adenosine Diphosphate 83-86 selectin P Homo sapiens 124-134 18282622-4 2009 Platelet reactivity was assessed by ADP-induced aggregation and activation was measured by p-selectin, total and active GPIIb/IIIa expression, and platelet-leukocyte aggregates in. Adenosine Diphosphate 36-39 selectin P Homo sapiens 91-101 19073150-9 2009 Furthermore, ADP activated RhoA downstream of G(q) and upstream of PLC. Adenosine Diphosphate 13-16 heparan sulfate proteoglycan 2 Homo sapiens 67-70 19161974-1 2009 The oxidation of critical cysteines/related thiols of adenine nucleotide translocase (ANT) is believed to be an important event of the Ca(2+)-induced mitochondrial permeability transition (MPT), a process mediated by a cyclosporine A/ADP-sensitive permeability transition pores (PTP) opening. Adenosine Diphosphate 234-237 solute carrier family 25 member 6 Homo sapiens 86-89 19161974-2 2009 We addressed the ANT-Cys(56) relative mobility status resulting from the interaction of ANT/surrounding cardiolipins with Ca(2+) and/or ADP by means of computational chemistry analysis (Molecular Interaction Fields and Molecular Dynamics studies), supported by classic mitochondrial swelling assays. Adenosine Diphosphate 136-139 solute carrier family 25 member 6 Homo sapiens 17-20 19161974-4 2009 The binding of ADP that stabilizes the conformation "m" of ANT and/or cardiolipin, respectively to H5 and H4 helices, could stabilize their contacts with the short helix h56 that includes Cys(56), accounting for reducing its relative mobility. Adenosine Diphosphate 15-18 solute carrier family 25 member 6 Homo sapiens 59-62 19234185-3 2009 Although ATP acts as a soluble ligand to activate P2X(7), gating of P2X(7) by NAD(+) requires ecto-ADP-ribosyltransferase ART2.2-catalyzed transfer of the ADP-ribose moiety from NAD(+) onto Arg125 of P2X(7). Adenosine Diphosphate 99-102 ADP-ribosyltransferase 2b Mus musculus 122-128 19236702-6 2009 Hypothermia also increased ADP-induced aggregation after pretreatment with the P2Y1 antagonist MRS2500. Adenosine Diphosphate 27-30 purinergic receptor P2Y1 Homo sapiens 79-83 19124027-3 2009 Here, we report the crystal structures of wild-type human Nek2 kinase domain bound to ADP at 1.55-A resolution and T175A mutant in apo form as well as that bound to a non-hydrolyzable ATP analog. Adenosine Diphosphate 86-89 NIMA related kinase 2 Homo sapiens 58-62 18945756-12 2009 Cardiomyocyte-restricted overexpression of ANT1 prevents the development of diabetic cardiomyopathy; therefore, accelerated ADP/ATP exchange could be a new promising target to treat diabetic cardiomyopathy. Adenosine Diphosphate 124-127 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 43-47 19109413-1 2009 Potato tuber (Solanum tuberosum) mitochondria (PTM) have a mitochondrially bound hexokinase (HK) activity that exhibits a pronounced sensitivity to ADP inhibition. Adenosine Diphosphate 148-151 hexokinase-1 Solanum tuberosum 81-91 19151156-2 2009 We present a crystal structure of a truncated form of the human RECQ1 protein with Mg-ADP. Adenosine Diphosphate 83-89 RecQ like helicase Homo sapiens 64-69 19135893-2 2009 We have determined the X-ray crystal structure of the NOD catalytic domain in the ADP- and AMPPNP-bound states. Adenosine Diphosphate 82-85 no distributive disjunction Drosophila melanogaster 54-57 19135893-6 2009 Our pre-steady-state kinetic analysis demonstrates that NOD interaction with microtubules occurs slowly with weak activation of ADP product release. Adenosine Diphosphate 128-131 no distributive disjunction Drosophila melanogaster 56-59 18715873-2 2008 They are constituted by two proteins: a pore-forming K(+) channel subunit (Kir6.1, Kir6.2) and a regulatory sulfonylurea receptor (SUR) subunit, an ATP-binding cassette (ABC) transporter that confers MgADP stimulation to the channel. Adenosine Diphosphate 200-205 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 53-81 18755689-2 2008 We found that ADP-induced phosphorylation of pleckstrin, the main platelet substrate for PKC, was completely inhibited not only by an antagonist of the G(q)-coupled P2Y1 receptor but also upon blockade of the G(i)-coupled P2Y12 receptor. Adenosine Diphosphate 14-17 purinergic receptor P2Y1 Homo sapiens 165-178 18599626-5 2008 In the M.ADP state, myosin heads are also disordered. Adenosine Diphosphate 9-12 myosin heavy chain 14 Homo sapiens 20-26 18806800-3 2008 On the basis of new structural and mutagenesis data, we propose a model mechanism for microtubule activation of Mg-ADP release from KIF1A. Adenosine Diphosphate 112-118 kinesin family member 1A Homo sapiens 132-137 18841284-3 2008 One hundred consecutive patients with coronary artery disease (CAD) on combined acetylsalicylic acid and clopidogrel treatment (75 mg/d) and 33 patients on aspirin only were screened for platelet ADP-induced signalling by conventional aggregometry, platelet P-selectin expression and the platelet reactivity index (PRI). Adenosine Diphosphate 196-199 selectin P Homo sapiens 258-268 18841285-4 2008 After stimulation with 20 muM ADP, 2 hours after LD, significantly lower expression of activated GPIIb/IIIa (4.3 vs. 21.8 [mean fluorescent intensity (MFI)], p < 0.001) and P-selectin (2.0 vs. 11.7 MFI, p < 0.001) along with decreased formation of platelet-monocyte aggregates (16.4% vs. 29.6% positive cells, p < 0.001) was observed with prasugrel versus clopidogrel. Adenosine Diphosphate 30-33 selectin P Homo sapiens 176-186 18729359-0 2008 Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel. Adenosine Diphosphate 11-14 solute carrier family 25 member 4 Bos taurus 36-51 18729359-1 2008 The ADP/ATP carrier (AAC) is a membrane protein of paramount importance for the energy-fueling function of the mitochondria, transporting ADP from the intermembrane space to the matrix and ATP in the opposite direction. Adenosine Diphosphate 4-7 solute carrier family 25 member 4 Bos taurus 21-24 18729359-6 2008 Systematic association of ADP (3-) to the crevice of the AAC, an early event in its transport across the inner membrane, is accompanied by the formation of an intricate network of noncovalent bonds. Adenosine Diphosphate 26-29 solute carrier family 25 member 4 Bos taurus 57-60 18579579-7 2008 This increase in PTEN is reversed when cells are supplemented with ATP, ADP or AMP. Adenosine Diphosphate 72-75 phosphatase and tensin homolog Homo sapiens 17-21 18668042-3 2008 The ability of myosin Va to move processively is a function of its long lever arm, the high duty ratio of its kinetic cycle and the gating of the kinetics between the two heads such that ADP release from the lead head is greatly retarded. Adenosine Diphosphate 187-190 myosin VA Mus musculus 15-24 18668042-6 2008 Here we show that preferential ADP dissociation from the trail head of mouse myosin Va is followed by ATP binding and a synchronous 36-nm step. Adenosine Diphosphate 31-34 myosin VA Mus musculus 77-86 18668042-7 2008 Even at low ATP concentrations, the myosin Va molecule retained at least one nucleotide (ADP in the lead head position) when moving. Adenosine Diphosphate 89-92 myosin VA Mus musculus 36-45 18614813-8 2008 The slope of nu(max) versus [MgADP] was significantly greater for tonic (-0.51+/-0.04) than phasic muscle myosin (-0.15+/-0.04), demonstrating the greater MgADP affinity of myosin from tonic muscle. Adenosine Diphosphate 155-160 myosin heavy chain 14 Homo sapiens 106-112 18614813-11 2008 We conclude that the greater affinity for MgADP of tonic muscle myosin and the reattachment of dephosphorylated myosin to actin may both contribute to the latch state. Adenosine Diphosphate 42-47 myosin heavy chain 14 Homo sapiens 64-70 18627435-4 2008 ADP and ADPbetaS-induced [Ca(2+)](i) increase and glutamate release are mediated by P2Y(1) receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 84-99 19065903-5 2008 RESULTS: The first determination showed the plasma level of P-selectin and TXB2 concentration were positively correlated with PAG, either induced by AA (r = 0.449, P < 0.01 and r = 0.576, P < 0.01) or by ADP (r = 0.525, P < 0.01; r = 0.501, P < 0.01). Adenosine Diphosphate 210-213 selectin P Homo sapiens 60-70 18260108-1 2008 Hexokinase is the first enzyme in the glycolytic pathway that catalyzes the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP. Adenosine Diphosphate 159-162 hexokinase Saccharomyces cerevisiae S288C 0-10 18373493-0 2008 The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A. eEF2 (eukaryotic elongation factor 2) contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of diphtheria toxin, cholix toxin and Pseudomonas aeruginosa exotoxin A. Site-directed mutagenesis was conducted on residues within the diphthamide-containing loop (Leu693-Gly703) of eEF2 by replacement with alanine. Adenosine Diphosphate 85-88 elongation factor 2 Saccharomyces cerevisiae S288C 62-81 18462755-0 2008 Molecular mechanism of ADP-ribose hydrolysis by human NUDT5 from structural and kinetic studies. Adenosine Diphosphate 23-26 nudix hydrolase 5 Homo sapiens 54-59 18462755-1 2008 Human NUDT5 (hNUDT5) is an ADP-ribose (ADPR) pyrophosphatase (ADPRase) that plays important roles in controlling the intracellular levels of ADPR and preventing non-enzymatic ADP-ribosylation of proteins by hydrolyzing ADPR to AMP and ribose 5"-phosphate. Adenosine Diphosphate 27-30 nudix hydrolase 5 Homo sapiens 6-11 18462755-1 2008 Human NUDT5 (hNUDT5) is an ADP-ribose (ADPR) pyrophosphatase (ADPRase) that plays important roles in controlling the intracellular levels of ADPR and preventing non-enzymatic ADP-ribosylation of proteins by hydrolyzing ADPR to AMP and ribose 5"-phosphate. Adenosine Diphosphate 27-30 nudix hydrolase 5 Homo sapiens 13-19 29574692-1 2018 BACKGROUND AND PURPOSE: The Gi -coupled, ADP-activated P2Y12 receptor is well characterized as playing a key role in platelet activation via crosstalk with the P2Y1 receptor in ADP-evoked intracellular Ca2+ responses. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 160-173 29574692-6 2018 Loss of ADP-evoked Ca2+ responses following treatment with MRS2578 (IC50 200 nM) revealed a major role for P2Y6 receptors in mediating ADP-evoked Ca2+ responses. Adenosine Diphosphate 8-11 pyrimidinergic receptor P2Y6 Homo sapiens 107-111 29574692-6 2018 Loss of ADP-evoked Ca2+ responses following treatment with MRS2578 (IC50 200 nM) revealed a major role for P2Y6 receptors in mediating ADP-evoked Ca2+ responses. Adenosine Diphosphate 135-138 pyrimidinergic receptor P2Y6 Homo sapiens 107-111 18499605-10 2008 Low-dose sevoflurane inhalation reduced ADP-induced CD62P expression on platelets 24 h after inhalation, and inhibited the formation of granulocyte-platelet aggregates under stimulation with AA and ADP after 1 and 24 h, and with TRAP-6 after 24 h compared with control. Adenosine Diphosphate 40-43 selectin P Homo sapiens 52-57 29669386-9 2018 Unlike its mammalian homologue, NPP5, the schistosome protein cleaves ADP and with a Km of 246 +- 34 microM. Adenosine Diphosphate 70-73 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 Homo sapiens 32-36 18418069-4 2008 Given that Nudix domains are known to bind nucleoside diphosphate sugars and NAD, we predict that this domain in DBC1 and its homologs binds NAD metabolites such as ADP-ribose. Adenosine Diphosphate 165-168 cell cycle and apoptosis regulator 2 Homo sapiens 113-117 29534999-5 2018 Molecular docking of ADP and MRS2365 to P2Y1 was analysed using AutoDock Smina followed by GOLD molecular docking in the Accelrys Discovery Studio software. Adenosine Diphosphate 21-24 purinergic receptor P2Y1 Homo sapiens 40-44 18319055-3 2008 Sucrose density gradient centrifugation demonstrated co-sedimentation of recombinant factor B with the ADP/ATP carrier, which is present in preparations of H(+)-translocating F(0)F(1)-ATPase, but not in preparations of complex V. The N-terminally truncated factor B mutant FB(DeltaW)(2)(-W)(4) did not co-sediment with the ADP/ATP carrier. Adenosine Diphosphate 103-106 distal membrane arm assembly component 2 like Bos taurus 85-93 18319055-3 2008 Sucrose density gradient centrifugation demonstrated co-sedimentation of recombinant factor B with the ADP/ATP carrier, which is present in preparations of H(+)-translocating F(0)F(1)-ATPase, but not in preparations of complex V. The N-terminally truncated factor B mutant FB(DeltaW)(2)(-W)(4) did not co-sediment with the ADP/ATP carrier. Adenosine Diphosphate 103-106 distal membrane arm assembly component 2 like Bos taurus 257-265 29685928-2 2018 These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR1 or SUR2A/B) subunits, detect metabolic changes via three classes of intracellular adenine nucleotide (ATP/ADP) binding site. Adenosine Diphosphate 248-251 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 87-93 18319055-3 2008 Sucrose density gradient centrifugation demonstrated co-sedimentation of recombinant factor B with the ADP/ATP carrier, which is present in preparations of H(+)-translocating F(0)F(1)-ATPase, but not in preparations of complex V. The N-terminally truncated factor B mutant FB(DeltaW)(2)(-W)(4) did not co-sediment with the ADP/ATP carrier. Adenosine Diphosphate 323-326 distal membrane arm assembly component 2 like Bos taurus 85-93 18343032-2 2008 ADP (10microM) evoked increases in intracellular calcium that were essentially abolished by the P2Y(1) receptor antagonist MRS2179 (10microM), responses were also absent in preparations from P2Y(1) receptor deficient mice however UTP (100microM) evoked calcium rises were unaffected. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 96-111 29604959-9 2018 The effects of isoform specific agonists and antagonists suggested that both P2Y1 and P2Y13 were obligatory for ADP responses, while P2Y4 and P2Y11 served as primary UTP and ATP receptors, respectively. Adenosine Diphosphate 112-115 purinergic receptor P2Y1 Homo sapiens 77-81 18343032-2 2008 ADP (10microM) evoked increases in intracellular calcium that were essentially abolished by the P2Y(1) receptor antagonist MRS2179 (10microM), responses were also absent in preparations from P2Y(1) receptor deficient mice however UTP (100microM) evoked calcium rises were unaffected. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 191-206 18343032-3 2008 ADP also evoked a robust increase in extracellular signal-regulated protein kinase (ERK) phosphorylation that was of similar magnitude in the cultures from wild type and P2Y(1) receptor deficient mice. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 170-185 29795342-7 2018 The Ub Arg72 might act as a "probe" that interacts with the mART domain first, and then movements may occur in the side chains of Arg72 and Arg42 during the ADP-ribosylation of Ub. Adenosine Diphosphate 157-160 ADP-ribosyltransferase 2b Mus musculus 60-64 18392330-9 2008 Samples from EPO-treated rats showed an attenuated response to ADP in whole blood aggregometry and thrombelastography (TEG) platelet mapping but not in apyrase-treated PRP, suggesting involvement of ADP receptor desensitization. Adenosine Diphosphate 63-66 erythropoietin Rattus norvegicus 13-16 28406726-1 2018 Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Galphaq, Galphai, and Galpha12/13 proteins. Adenosine Diphosphate 61-82 G protein subunit alpha q Homo sapiens 188-195 18237742-7 2008 ADP-P(i) and RNA binding display strong thermodynamic coupling, which causes DbpA-ADP-P(i) to bind rRNA with >10-fold higher affinity than with bound ATP, ADP or in the absence of nucleotide. Adenosine Diphosphate 0-3 Y-box binding protein 3 Homo sapiens 77-81 18174464-0 2008 ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 52-56 28406726-1 2018 Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Galphaq, Galphai, and Galpha12/13 proteins. Adenosine Diphosphate 84-87 G protein subunit alpha q Homo sapiens 188-195 28406726-7 2018 Further enhancement of P-selectin expression was achieved by ADP-induced combined signaling of Galphaq and Galphai, and to more extent by U46619 at high concentration (1.5 muM) induced combined signaling of Galphaq and Galpha12/13 while maximal P-selectin expression was achieved by thrombin receptor-activating peptide (TRAP)-induced combined signaling of Galphaq, Galphai, and Galpha12/13. Adenosine Diphosphate 61-64 selectin P Homo sapiens 23-33 18082609-3 2007 Strikingly, the ADP-bound form of Dbp5 and not ATP hydrolysis is required for RNP remodeling. Adenosine Diphosphate 16-19 DEAD-box helicase 19B Homo sapiens 34-38 28406726-7 2018 Further enhancement of P-selectin expression was achieved by ADP-induced combined signaling of Galphaq and Galphai, and to more extent by U46619 at high concentration (1.5 muM) induced combined signaling of Galphaq and Galpha12/13 while maximal P-selectin expression was achieved by thrombin receptor-activating peptide (TRAP)-induced combined signaling of Galphaq, Galphai, and Galpha12/13. Adenosine Diphosphate 61-64 G protein subunit alpha q Homo sapiens 95-102 17925398-7 2007 Nucleotide binding appears to be tighter compared with other Hsp90s investigated, with dissociation constants (K(D)) of approximately 4 microm for ADP, ATP, and AMP-PCP. Adenosine Diphosphate 147-150 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 61-66 29725296-5 2018 As the P2Y12 receptor for ADP is coupled to the inhibitory Gi protein, we asked whether blocking the P2Y12 receptor with ticagrelor could restore lysosomal acidity and reduce autofluorescence in compromised RPE cells from ABCA4-/- mice. Adenosine Diphosphate 26-29 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 7-12 18064327-7 2007 In FA patients platelet reactivity was decreased: Expression of P-selectin and binding of PAC-1 after stimulation with thrombin receptor activating peptide (TRAP) and adenosine diphosphate (ADP) were 15-70% lower than in controls. Adenosine Diphosphate 167-188 selectin P Homo sapiens 64-74 18064327-7 2007 In FA patients platelet reactivity was decreased: Expression of P-selectin and binding of PAC-1 after stimulation with thrombin receptor activating peptide (TRAP) and adenosine diphosphate (ADP) were 15-70% lower than in controls. Adenosine Diphosphate 167-188 ADCYAP receptor type I Homo sapiens 90-95 18064327-7 2007 In FA patients platelet reactivity was decreased: Expression of P-selectin and binding of PAC-1 after stimulation with thrombin receptor activating peptide (TRAP) and adenosine diphosphate (ADP) were 15-70% lower than in controls. Adenosine Diphosphate 190-193 selectin P Homo sapiens 64-74 18064327-7 2007 In FA patients platelet reactivity was decreased: Expression of P-selectin and binding of PAC-1 after stimulation with thrombin receptor activating peptide (TRAP) and adenosine diphosphate (ADP) were 15-70% lower than in controls. Adenosine Diphosphate 190-193 ADCYAP receptor type I Homo sapiens 90-95 18064330-7 2007 Clopidogrel treatment inhibited ADP-induced platelet P-selectin expression by 64% (22-87%), and attenuated the P-selectin response to thrombin (p < 0.001), and platelet aggregation induced by low-dose collagen (p < 0.01). Adenosine Diphosphate 32-35 selectin P Homo sapiens 53-63 29522284-8 2018 Additionally, AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) in the PI3K/AKT/ARNT signaling pathway, which promoted apoptosis and necrosis in GC cells. Adenosine Diphosphate 14-17 aryl hydrocarbon receptor nuclear translocator Homo sapiens 144-148 17982416-6 2007 For calcium imaging, cells were plated on gelatin-coated coverslips, bathed in calcium Ringer"s solution, and loaded with fluo-4 (5 microM) for 1 h. Agonists of P2Y1 (ADP) and P2Y2/P2Y4 (ATP, UTP) receptors at 10 microM or 100 microM concentrations were added to the bathing medium. Adenosine Diphosphate 167-170 purinergic receptor P2Y1 Homo sapiens 161-165 29522284-8 2018 Additionally, AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) in the PI3K/AKT/ARNT signaling pathway, which promoted apoptosis and necrosis in GC cells. Adenosine Diphosphate 14-17 aryl hydrocarbon receptor nuclear translocator Homo sapiens 166-170 29522284-9 2018 AdP promoted apoptosis in CDDP-resistant GC cells by suppressing the PI3K/AKT/ARNT signaling pathway and might be considered a candidate agent for the clinical treatment of cisplatin-resistant GC. Adenosine Diphosphate 0-3 aryl hydrocarbon receptor nuclear translocator Homo sapiens 78-82 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 33-54 ADP ribosylation factor like GTPase 2 Homo sapiens 89-93 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 33-54 protein phosphatase 2 phosphatase activator Homo sapiens 194-198 29554700-10 2018 An alternative method of platelet activation using platelet agonists 20 microM ADP or 10 microM epinephrine also increased CD62P+ EV levels, and this too was attenuated by prior incubation with colchicine. Adenosine Diphosphate 79-82 selectin P Homo sapiens 123-128 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 56-59 ADP ribosylation factor like GTPase 2 Homo sapiens 89-93 17651460-6 2007 Deletions caused a defect in the adenosine diphosphate (ADP)-ribosylation factor-like 2 (ARL2) transcript, which is known to be important in secretion and interacts with protein phosphatase 2A (PP2A) and thus AMPK. Adenosine Diphosphate 56-59 protein phosphatase 2 phosphatase activator Homo sapiens 194-198 23484535-2 2007 Hsp90 is a conformationally flexible protein that associates with a distinct set of cochaperones depending on ATP or ADP occupancy of an N-terminal binding pocket. Adenosine Diphosphate 117-120 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 46-49 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 97-105 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 46-49 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 106-110 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 97-105 17496049-3 2007 FLIM reveals that the lifetime of the nucleotide, in its ADP form because of the low concentration of nucleotide present, changes depending on whether the nucleotide is free in solution or bound to myosin, and on whether the myosin is bound to actin in an actomyosin complex. Adenosine Diphosphate 57-60 myosin heavy chain 14 Homo sapiens 198-204 29382767-4 2018 However, attempting to raise the level of ATP/ADP by blocking the endogenous ecto-ATPase (termed NTPDase1/CD39), which also hydrolyzes ATP/ADP, does not affect the cells" ramification or surveillance, nor their membrane currents, which respond to even small rises of extracellular [ATP] or [ADP] with the activation of K+ channels. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 106-110 17496049-3 2007 FLIM reveals that the lifetime of the nucleotide, in its ADP form because of the low concentration of nucleotide present, changes depending on whether the nucleotide is free in solution or bound to myosin, and on whether the myosin is bound to actin in an actomyosin complex. Adenosine Diphosphate 57-60 myosin heavy chain 14 Homo sapiens 225-231 17524547-3 2007 In both cases, the chimeric carrier, Anc2-Cyc1(His6)p, was able to restore growth on a non-fermentable carbon source of a yeast strain devoid of functional ADP/ATP carrier, demonstrating its transport activity. Adenosine Diphosphate 156-159 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 42-46 17524547-10 2007 Improved production and purification of Anc2-Cyc1(His6)p-CATR complex opens up new possibilities for the use of this protein in crystallographic approaches to the yeast ADP/ATP carrier. Adenosine Diphosphate 169-172 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 45-49 17524547-11 2007 Furthermore, Anc2-Cyc1(His6)p may be an useful molecular tool to investigate in vivo interactions between components of the respiratory chain complexes such as COX and the proteins implicated in ATP biogenesis, such as the ATP/ADP carrier. Adenosine Diphosphate 227-230 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 18-22 29439388-2 2018 Platelet activation by ADP is associated with the G protein-coupled receptors P2Y1 and P2Y12. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 78-82 17451439-13 2007 The increased ATP and ADP hydrolysis in group IV was confirmed by an increase in CD39 expression on its surface. Adenosine Diphosphate 22-25 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 81-85 29576747-6 2018 This review is focused on investigations on the role of CD38-cyclic ADP-ribose signaling in airway smooth muscle in the context of transcriptional and posttranscriptional regulation of CD38 expression. Adenosine Diphosphate 68-71 CD38 molecule Homo sapiens 56-60 29576747-6 2018 This review is focused on investigations on the role of CD38-cyclic ADP-ribose signaling in airway smooth muscle in the context of transcriptional and posttranscriptional regulation of CD38 expression. Adenosine Diphosphate 68-71 CD38 molecule Homo sapiens 185-189 17504816-4 2007 The extent of inhibition by ADP of the motility of MYA1 was similar to that of the well-known processive motor, myosin V, suggesting that MYA1 is a processive motor. Adenosine Diphosphate 28-31 myosin 1 Arabidopsis thaliana 51-55 17504816-4 2007 The extent of inhibition by ADP of the motility of MYA1 was similar to that of the well-known processive motor, myosin V, suggesting that MYA1 is a processive motor. Adenosine Diphosphate 28-31 myosin 1 Arabidopsis thaliana 138-142 29343827-4 2018 We confirm the involvement of NUDT5 in ADP-ribose metabolism and dissociate a relationship to oxidized nucleotide sanitation. Adenosine Diphosphate 39-42 nudix hydrolase 5 Homo sapiens 30-35 17504816-5 2007 The dissociation rate of the actin-MYA1-ADP complex induced by ATP (73.5 s(-1)) and the V(max) value of the actin-activated Mg(2+) ATPase activity revealed that MYA1 stays in the actin-bound state for about 70% of its mechanochemical cycle time. Adenosine Diphosphate 40-43 myosin 1 Arabidopsis thaliana 35-39 17504816-5 2007 The dissociation rate of the actin-MYA1-ADP complex induced by ATP (73.5 s(-1)) and the V(max) value of the actin-activated Mg(2+) ATPase activity revealed that MYA1 stays in the actin-bound state for about 70% of its mechanochemical cycle time. Adenosine Diphosphate 40-43 myosin 1 Arabidopsis thaliana 161-165 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 26-50 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 83-87 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 26-50 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 89-94 17602871-6 2007 CD62 positive platelet percentage after ADP were decreased significantly on the 3rd and 5th days compared to the 1st day in Kansuk bags. Adenosine Diphosphate 40-43 selectin P Homo sapiens 0-4 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 26-50 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 99-104 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 52-55 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 83-87 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 52-55 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 89-94 27867196-3 2018 Here, we demonstrate that adenosine 5"-diphosphate (ADP), the endogenous ligand of P2Y1, P2Y12 and P2Y13, was released both in E. coli-infected mice and from macrophages treated with either lipopolysaccharide (LPS) or Pam3CSK4. Adenosine Diphosphate 52-55 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 99-104 17487986-6 2007 The model explains the surprising experimental finding that myosin walks at a faster speed but for a shorter distance as the ATP concentration increases in the absence of ADP. Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 60-66 17487986-7 2007 It also suggests that under physiological condition ([ADP] approximately 12-50 microM), myosin walks with a higher speed and for longer distances when ATP is more abundant. Adenosine Diphosphate 54-57 myosin heavy chain 14 Homo sapiens 88-94 27867196-8 2018 However, either P2Y12/P2Y13 deficiency or blocking the downstream signaling of P2Y12/P2Y13 blocked the ADP-mediated immune response and allowed more bacteria to persist in the infected mice. Adenosine Diphosphate 103-106 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 16-21 29197873-5 2018 The effect of OECs and their supernatant on the adenosine diphosphate (ADP)-induced magnitude of platelet integrin receptor alphaIIbbeta3 activation and on P-selectin membrane expression was investigated. Adenosine Diphosphate 71-74 selectin P Homo sapiens 156-166 17432878-1 2007 Human NAD-dependent isocitrate dehydrogenase (IDH) is allosterically activated by ADP by lowering the Km for isocitrate. Adenosine Diphosphate 82-85 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 46-49 17480228-3 2007 CD39 is the major promoter of platelet inhibition in vivo via its metabolism of ADP to AMP. Adenosine Diphosphate 80-83 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 29188558-2 2018 We illustrate here how this applies to A2A adenosine receptors (ARs) and to P2Y1 and P2Y12 receptors (P2YRs) for ADP. Adenosine Diphosphate 113-116 purinergic receptor P2Y1 Homo sapiens 76-80 29061706-2 2018 We recently reported that an M. pneumoniae-derived ADP-ribosylating and vacuolating toxin called community-acquired respiratory distress syndrome (CARDS) toxin is capable of triggering NLRP3 (NLR-family, leucine-rich repeat protein 3) inflammasome activation and interleukin-1beta (IL-1beta) secretion in macrophages. Adenosine Diphosphate 51-54 NLR family, pyrin domain containing 3 Mus musculus 185-190 17362227-2 2007 We now show that selective inhibition of P2X(1) receptors substantially reduces the [Ca(2+)](i) increase evoked by several important agonists in human platelets; for collagen, thromboxane A(2), thrombin, and adenosine 5"-diphoshate (ADP) the maximal effect was a reduction to 18%, 34%, 52%, and 69% of control, respectively. Adenosine Diphosphate 233-236 purinergic receptor P2X 1 Homo sapiens 41-47 17653469-2 2007 The results showed that the percentage of P-selectin in platelets without agonist stimulation was 10.6% in F3, 11.1% in F0 and 6.3% in C. After the addition of ADP/adrenaline, the percentages were 44%, 25.3% and 42%, respectively. Adenosine Diphosphate 160-163 selectin P Homo sapiens 42-52 17381624-9 2007 Correspondingly, a reduced capacity for up regulation of CD62P expression and down regulation of CD42b was observed in PCT PLTs after stimulation by the agonists ADP or TRAP. Adenosine Diphosphate 162-165 selectin P Homo sapiens 57-62 29348817-3 2017 Binding of PU-H71-TPP to ADP-Hsp90, Hsp90 co-chaperone complex or mitochondrial Hsp90 homolog, TRAP1 involved hydrogen bonds, pi-pi stacking, cation-pi contacts and hydrophobic interactions with the surrounding amino acids in the active site. Adenosine Diphosphate 25-28 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-34 17137571-0 2007 Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece. Adenosine Diphosphate 33-36 solute carrier family 25 member 31 Homo sapiens 95-99 17260965-4 2007 Non-phosphorylated MEK1 (npMEK1) has a high affinity for both AMP-PNP and ADP (Kd approximately 2microM). Adenosine Diphosphate 74-77 mitogen-activated protein kinase kinase 1 Homo sapiens 19-23 28947214-2 2017 In humans, mutations in the major ADP/ATP carrier gene, ANT1, are involved in several degenerative mitochondrial pathologies, leading to instability of mitochondrial DNA. Adenosine Diphosphate 34-37 solute carrier family 25 member 4 Homo sapiens 56-60 17365850-2 2007 beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. Adenosine Diphosphate 81-84 apolipoprotein H Homo sapiens 0-20 17365850-2 2007 beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. Adenosine Diphosphate 81-84 apolipoprotein H Homo sapiens 22-32 17365850-4 2007 We demonstrate dose-dependent inhibition of ADP-induced platelet aggregation in cord whole blood (WB) in the presence of increasing amounts of beta2-GP-I, evaluated by means of WB aggregometry employing the impedance method. Adenosine Diphosphate 44-47 apolipoprotein H Homo sapiens 143-153 29312595-1 2017 Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP, a rate-limiting reaction in glycolysis. Adenosine Diphosphate 73-76 pyruvate kinase M1/2 Homo sapiens 17-19 17365850-6 2007 In conclusion, physiological low levels of beta2-GP-I in cord WB cause enhanced responsiveness of neonatal platelets to ADP stimulation. Adenosine Diphosphate 120-123 apolipoprotein H Homo sapiens 43-53 16980436-5 2006 RINm5F-GK-PFK-2/FBPase-2 cells showed under this culture condition a significant increase in glucose utilization and in the ATP/ADP ratio compared with RINm5F-GK cells, which only overexpress glucokinase. Adenosine Diphosphate 128-131 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Rattus norvegicus 10-15 28958680-8 2017 Furthermore, cTnI(1-167) slowed MgADP release rate and enhanced cross-bridge binding. Adenosine Diphosphate 32-37 troponin I3, cardiac type Rattus norvegicus 13-17 17259553-5 2006 The chaperone function of HSP90 requires the formation of a multichaperone complex, which is dependent on the hydrolysis of ATP and ADP/ATP exchange. Adenosine Diphosphate 132-135 heat shock protein 90 alpha family class A member 1 Homo sapiens 26-31 29062134-1 2017 The human P2Y1 receptor (P2Y1R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 115-139 purinergic receptor P2Y1 Homo sapiens 10-23 17108170-3 2006 Whole-cell current-clamp recordings of GnRH neurons in brain slices from ovariectomized mice revealed a slow ADP (sADP) after action potentials generated by brief current injection. Adenosine Diphosphate 109-112 gonadotropin releasing hormone 1 Mus musculus 39-43 16921171-5 2006 In the absence of calcium, bound ADP weakens the affinity of one head for actin filaments at equilibrium and upon initial encounter. Adenosine Diphosphate 33-36 actin, beta Gallus gallus 74-79 16921171-6 2006 The addition of calcium allows both heads of myosin Va.ADP to bind actin strongly. Adenosine Diphosphate 55-58 actin, beta Gallus gallus 67-72 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 40-43 actin, beta Gallus gallus 146-151 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 87-90 actin, beta Gallus gallus 146-151 16921171-9 2006 In the absence of calcium, inclusion of ADP favors formation of a long lived myosin Va.ADP state that releases ADP slowly, even after mixing with actin. Adenosine Diphosphate 87-90 actin, beta Gallus gallus 146-151 29062134-1 2017 The human P2Y1 receptor (P2Y1R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 115-139 purinergic receptor P2Y1 Homo sapiens 25-30 29062134-1 2017 The human P2Y1 receptor (P2Y1R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 141-144 purinergic receptor P2Y1 Homo sapiens 10-23 16817779-4 2006 HNP1 (human neutrophil protein 1) inhibited DT- or ETA-mediated ADP-ribosylation of eEF2 (eukaryotic elongation factor 2) and protected HeLa cells against DT- or ETA-induced cell death. Adenosine Diphosphate 64-67 eukaryotic translation elongation factor 2 Homo sapiens 90-120 29062134-1 2017 The human P2Y1 receptor (P2Y1R) is a purinergic G-protein-coupled receptor (GPCR) that functions as a receptor for adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 141-144 purinergic receptor P2Y1 Homo sapiens 25-30 29062134-6 2017 This new site is deeper than those of the agonist ADP in the recently simulated ADP-P2Y1R structure and the antagonist MRS2500 in the MRS2500-P2Y1R crystal structure. Adenosine Diphosphate 50-53 purinergic receptor P2Y1 Homo sapiens 84-89 29062134-6 2017 This new site is deeper than those of the agonist ADP in the recently simulated ADP-P2Y1R structure and the antagonist MRS2500 in the MRS2500-P2Y1R crystal structure. Adenosine Diphosphate 50-53 purinergic receptor P2Y1 Homo sapiens 142-147 29062134-6 2017 This new site is deeper than those of the agonist ADP in the recently simulated ADP-P2Y1R structure and the antagonist MRS2500 in the MRS2500-P2Y1R crystal structure. Adenosine Diphosphate 80-83 purinergic receptor P2Y1 Homo sapiens 84-89 29031721-18 2017 We identified novel protein interactors of CDKAL1, including SLC25A4/ANT1, an inner mitochondrial membrane ADP/ATP translocator. Adenosine Diphosphate 107-110 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 61-68 17010792-2 2006 BACKGROUND: High post-treatment platelet reactivity (HPPR = adenosine diphosphate 10 mumol x l(-1) [ADP]-induced platelet aggregation >70%) is a marker for low responders to dual antiplatelet therapy with increased risk of recurrent cardiovascular (CV) events after stenting for NSTE ACS. Adenosine Diphosphate 60-81 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 287-290 17010792-2 2006 BACKGROUND: High post-treatment platelet reactivity (HPPR = adenosine diphosphate 10 mumol x l(-1) [ADP]-induced platelet aggregation >70%) is a marker for low responders to dual antiplatelet therapy with increased risk of recurrent cardiovascular (CV) events after stenting for NSTE ACS. Adenosine Diphosphate 100-103 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 287-290 17009310-14 2006 TG2 bound to GDP, ADP, or ATP (but not to GTP) rescued defective apoptotic leukocyte uptake by TG2-/- macrophages. Adenosine Diphosphate 18-21 transglutaminase 2, C polypeptide Mus musculus 0-3 17009310-14 2006 TG2 bound to GDP, ADP, or ATP (but not to GTP) rescued defective apoptotic leukocyte uptake by TG2-/- macrophages. Adenosine Diphosphate 18-21 transglutaminase 2, C polypeptide Mus musculus 95-98 16824188-4 2006 Surprisingly, in Fg/VWF(-/-) plasma without anticoagulant, adenosine diphosphate induced robust aggregation of Fg/VWF(-/-) platelets but not of beta(3)-integrin-deficient (beta(3) (-/-)) platelets. Adenosine Diphosphate 59-80 Von Willebrand factor Mus musculus 20-23 16824188-4 2006 Surprisingly, in Fg/VWF(-/-) plasma without anticoagulant, adenosine diphosphate induced robust aggregation of Fg/VWF(-/-) platelets but not of beta(3)-integrin-deficient (beta(3) (-/-)) platelets. Adenosine Diphosphate 59-80 Von Willebrand factor Mus musculus 114-117 16982757-2 2006 Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in healthy cells. Adenosine Diphosphate 62-65 solute carrier family 25 member 6 Homo sapiens 0-30 16982757-2 2006 Adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP on the inner mitochondrial membrane in healthy cells. Adenosine Diphosphate 62-65 solute carrier family 25 member 6 Homo sapiens 32-35 16943556-3 2006 Here we report that protein kinase C (PKC)-epsilon is critically involved in ADP. Adenosine Diphosphate 77-80 protein kinase C epsilon Homo sapiens 20-50 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 223-226 protein kinase C epsilon Homo sapiens 74-85 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 223-226 protein kinase C epsilon Homo sapiens 74-85 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 223-226 protein kinase C epsilon Homo sapiens 74-85 16807649-1 2006 Prolactin and leptin are newly recognised platelet co-stimulators due to potentiation of ADP-induced platelet aggregation. Adenosine Diphosphate 89-92 leptin Homo sapiens 14-20 16807649-4 2006 We determined plasma prolactin and leptin levels as well as platelet P-selectin expression in 36 patients with ischemic stroke or transient ischemic attack and detected a significant correlation between increased prolactin values and enhanced ADP stimulated P-selectin expression on platelets. Adenosine Diphosphate 243-246 selectin P Homo sapiens 69-79 16807649-4 2006 We determined plasma prolactin and leptin levels as well as platelet P-selectin expression in 36 patients with ischemic stroke or transient ischemic attack and detected a significant correlation between increased prolactin values and enhanced ADP stimulated P-selectin expression on platelets. Adenosine Diphosphate 243-246 selectin P Homo sapiens 258-268 16785439-5 2006 Surprisingly, we found that the myosin-ADP bond is possessed of longer lifetimes under load than rigor bonds, although the load at which bond lifetime is maximal remains unchanged. Adenosine Diphosphate 39-42 myosin heavy chain 14 Homo sapiens 32-38 16584705-8 2006 In addition, we demonstrate that ADP competitively inhibits phosphorylation of HDAC5 (K(i)=8.50, 17.54, and 11.98microM for PKD1, PKD2, and PKD3, respectively). Adenosine Diphosphate 33-36 polycystin 1, transient receptor potential channel interacting Homo sapiens 124-128 16595661-8 2006 Human HO-1 cDNA transfer into diabetic rats increased both HO-1 protein and activity, and restored mitochondrial ADP/ATP and deoxynucleotide carriers. Adenosine Diphosphate 113-116 heme oxygenase 1 Homo sapiens 6-10 20483248-1 2006 Creatine kinase (CK) catalyzes the reversible transfer of thegamma-terminal phosphate of MgATP to the guanidine creatine (Cr) forming MgADP and phosphocreatine (PCr). Adenosine Diphosphate 134-139 ckm Ciona intestinalis 0-15 20483248-1 2006 Creatine kinase (CK) catalyzes the reversible transfer of thegamma-terminal phosphate of MgATP to the guanidine creatine (Cr) forming MgADP and phosphocreatine (PCr). Adenosine Diphosphate 134-139 ckm Ciona intestinalis 17-19 16941047-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y(1) and P2Y(12)) plays a very important role in thrombogenesis. Adenosine Diphosphate 19-43 purinergic receptor P2Y1 Homo sapiens 79-85 16941047-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y(1) and P2Y(12)) plays a very important role in thrombogenesis. Adenosine Diphosphate 45-48 purinergic receptor P2Y1 Homo sapiens 79-85 16941047-9 2006 Along with new the P2Y(12) antagonists, inhibitors of the other platelet receptor for ADP, the antagonists P2Y(1), are under development and may prove to be effective antithrombotic agents. Adenosine Diphosphate 86-89 purinergic receptor P2Y1 Homo sapiens 107-113 16424066-5 2006 Although non-ADP-stimulated and maximally ADP-stimulated rates of respiration were 13% higher in HCR compared with LCR, the difference was not statistically significant (P>0.05). Adenosine Diphosphate 13-16 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 97-100 16424066-5 2006 Although non-ADP-stimulated and maximally ADP-stimulated rates of respiration were 13% higher in HCR compared with LCR, the difference was not statistically significant (P>0.05). Adenosine Diphosphate 42-45 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 97-100 16424066-6 2006 Despite a similar rate of respiration in the presence of 0.1 mM ADP, HCR rats demonstrated a higher rate of respiration in the presence of 0.1 mM ADP+20 mM creatine (HCR 33% higher vs. LCR, P<0.05). Adenosine Diphosphate 146-149 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 69-72 16424066-6 2006 Despite a similar rate of respiration in the presence of 0.1 mM ADP, HCR rats demonstrated a higher rate of respiration in the presence of 0.1 mM ADP+20 mM creatine (HCR 33% higher vs. LCR, P<0.05). Adenosine Diphosphate 146-149 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 166-169 16424066-7 2006 Thus mitochondria from HCR rats exhibit enhanced mitochondrial sensitivity to creatine (i.e., the ability of creatine to decrease the Km for ADP). Adenosine Diphosphate 141-144 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 23-26 16424066-8 2006 We propose that increased respiratory sensitivity to ADP in the presence of creatine can effectively increase muscle sensitivity to ADP during exercise (when creatine is increased) and may be, in part, a contributing factor for the increased running capacity in HCR rats. Adenosine Diphosphate 53-56 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 262-265 16424066-8 2006 We propose that increased respiratory sensitivity to ADP in the presence of creatine can effectively increase muscle sensitivity to ADP during exercise (when creatine is increased) and may be, in part, a contributing factor for the increased running capacity in HCR rats. Adenosine Diphosphate 132-135 coiled-coil alpha-helical rod protein 1 Rattus norvegicus 262-265 16734820-6 2006 RESULTS: Washed PLTs became refractory for ATP and ADP in shape change, aggregation, and Ca2+ responses during a 90-minute incubation at 37 degrees C. The PLT responses mediated by P2X1, P2Y1, and P2Y12 receptors gradually reduced or disappeared. Adenosine Diphosphate 51-54 purinergic receptor P2X 1 Homo sapiens 181-185 16540465-7 2006 The patterns of product inhibition of AKT1, AKT2, and AKT3 by ADP were all consistent with an ordered substrate addition mechanism with ATP binding to the enzymes prior to the peptide substrate. Adenosine Diphosphate 62-65 AKT serine/threonine kinase 2 Homo sapiens 44-48 16636497-4 2006 Compared with Group C, the mean fluorescence intensity of P-selectin in response to 0.1-10 micromol/L of ADP was significantly upregulated in Group A, but not in Group I. Adenosine Diphosphate 105-108 selectin P Homo sapiens 58-68 16636497-7 2006 CONCLUSIONS: P-selectin expression, but not activated GPIIb/IIIa, is enhanced in ADP-activated platelets from patients in the inflammatory stage of TA. Adenosine Diphosphate 81-84 selectin P Homo sapiens 13-23 16634757-7 2006 Preactivation of the P2Y1 receptor with MRS2365 for 2 min resulted in marked loss of capacity of ADP to induce aggregation as evidenced by a greater than 20-fold rightward shift in the concentration effect curve of ADP. Adenosine Diphosphate 97-100 purinergic receptor P2Y1 Homo sapiens 21-34 16634757-7 2006 Preactivation of the P2Y1 receptor with MRS2365 for 2 min resulted in marked loss of capacity of ADP to induce aggregation as evidenced by a greater than 20-fold rightward shift in the concentration effect curve of ADP. Adenosine Diphosphate 215-218 purinergic receptor P2Y1 Homo sapiens 21-34 16634757-9 2006 The inhibitory effect of preincubation with MRS2365 was circumvented by activation of the Gq-coupled 5-HT2A receptor suggesting that MRS2365 induces loss of the ADP response as a consequence of desensitization of the Gq-coupled P2Y1 receptor. Adenosine Diphosphate 161-164 purinergic receptor P2Y1 Homo sapiens 228-241 16634759-8 2006 Selective ADP receptor inhibitors attenuated P2X1-mediated priming, suggesting that the synergy between P2X1 and sub-threshold PAR1 stimulation was in part because of enhanced granular release of ADP. Adenosine Diphosphate 10-13 purinergic receptor P2X 1 Homo sapiens 45-49 16634759-8 2006 Selective ADP receptor inhibitors attenuated P2X1-mediated priming, suggesting that the synergy between P2X1 and sub-threshold PAR1 stimulation was in part because of enhanced granular release of ADP. Adenosine Diphosphate 10-13 purinergic receptor P2X 1 Homo sapiens 104-108 16489766-9 2006 These results suggest that ADP release is the rate-limiting step for the actin-activated ATPase cycle; thus, HuM5B is a high duty ratio myosin. Adenosine Diphosphate 27-30 myosin heavy chain 14 Homo sapiens 136-142 16322052-6 2006 An examination of ionic conductances generated by firing revealed that calcium entry through ICAT controls the emergence of the mAChR-mediated ADP. Adenosine Diphosphate 143-146 catenin beta interacting protein 1 Mus musculus 93-97 16308186-4 2006 A loading dose of 225 mg clopidogrel leads to a significant reduction (p < 0.01) in the ADP-stimulated retention index (RI) from 69 +/- 15 to 48 +/- 21%, in the aggregation response to 5 microM ADP (from 50 +/- 20 to 29 +/- 21%) and the expression of CD62P (from 64 +/- 11 to 41 +/- 17%). Adenosine Diphosphate 91-94 selectin P Homo sapiens 254-259 16308186-6 2006 We also found a strong correlation (p < 0.01) between the ADP-stimulated RI and the expression of CD62P after stimulation with 2 microM ADP, whereas no correlation was seen for RI vs. binding of PAC-1 or aggregation. Adenosine Diphosphate 61-64 selectin P Homo sapiens 101-106 16308186-6 2006 We also found a strong correlation (p < 0.01) between the ADP-stimulated RI and the expression of CD62P after stimulation with 2 microM ADP, whereas no correlation was seen for RI vs. binding of PAC-1 or aggregation. Adenosine Diphosphate 139-142 selectin P Homo sapiens 101-106 16278211-5 2006 We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Adenosine Diphosphate 71-74 ADP-ribosylserine hydrolase Homo sapiens 96-100 16860662-3 2006 The HSP90-based chaperone machine is driven by the hydrolysis of ATP and ADP/ATP nucleotide exchange. Adenosine Diphosphate 73-76 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 16921786-11 2006 CONCLUSIONS: Polymorphisms 45T > G a 276T > G of ADP gene and 62G>A and -180C > G RETN gene did not influence serum ADP and RETN concentrations. Adenosine Diphosphate 55-58 resistin Homo sapiens 94-98 16515502-3 2006 Two receptors for ADP, the G(q)-protein-coupled P2Y1 and G(i)-protein-coupled P2Y12 and one receptor for ATP, the P2X1 ion channel, have been identified on platelets. Adenosine Diphosphate 18-21 purinergic receptor P2Y1 Homo sapiens 48-52 16515502-3 2006 Two receptors for ADP, the G(q)-protein-coupled P2Y1 and G(i)-protein-coupled P2Y12 and one receptor for ATP, the P2X1 ion channel, have been identified on platelets. Adenosine Diphosphate 18-21 purinergic receptor P2X 1 Homo sapiens 114-118 16611109-3 2006 The P2Y(1) receptor is one of many platelet receptors coupled to Gq and initiates ADP-induced activation. Adenosine Diphosphate 82-85 purinergic receptor P2Y1 Homo sapiens 4-19 29031721-18 2017 We identified novel protein interactors of CDKAL1, including SLC25A4/ANT1, an inner mitochondrial membrane ADP/ATP translocator. Adenosine Diphosphate 107-110 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 69-73 28822683-0 2017 Hsp90 Sensitivity to ADP Reveals Hidden Regulation Mechanisms. Adenosine Diphosphate 21-24 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 16107323-1 2006 BACKGROUND: Impaired mitochondrial ADP/ATP transport and altered adenine nucleotide translocase (ANT) isoform expression characterized by enhanced ANT1 and decreased ANT2 expression have been implicated in the pathophysiology of dilated cardiomyopathy (DCM). Adenosine Diphosphate 35-38 solute carrier family 25 member 4 Homo sapiens 147-151 28822683-2 2017 Extensive analysis has focused on ATP-driven conformational changes of Hsp90; however, little is known about how Hsp90 operates under physiological nucleotide conditions in which both ATP and ADP are present. Adenosine Diphosphate 192-195 heat shock protein 90 alpha family class A member 1 Homo sapiens 113-118 16107323-1 2006 BACKGROUND: Impaired mitochondrial ADP/ATP transport and altered adenine nucleotide translocase (ANT) isoform expression characterized by enhanced ANT1 and decreased ANT2 expression have been implicated in the pathophysiology of dilated cardiomyopathy (DCM). Adenosine Diphosphate 35-38 solute carrier family 25 member 6 Homo sapiens 166-170 28822683-3 2017 By quantifying Hsp90 activity under mixed nucleotide conditions, we find dramatic differences in ADP sensitivity among Hsp90 homologs. Adenosine Diphosphate 97-100 heat shock protein 90 alpha family class A member 1 Homo sapiens 15-20 28822683-3 2017 By quantifying Hsp90 activity under mixed nucleotide conditions, we find dramatic differences in ADP sensitivity among Hsp90 homologs. Adenosine Diphosphate 97-100 heat shock protein 90 alpha family class A member 1 Homo sapiens 119-124 28822683-4 2017 ADP acts as a strong ATPase inhibitor of cytosol-specific Hsp90 homologs, whereas organellular Hsp90 homologs (Grp94 and TRAP1) are relatively insensitive to the presence of ADP. Adenosine Diphosphate 0-3 heat shock protein 90 alpha family class A member 1 Homo sapiens 58-63 28822683-5 2017 These results imply that an ATP/ADP heterodimer of cytosolic Hsp90 is the predominant active state under physiological nucleotide conditions. Adenosine Diphosphate 32-35 heat shock protein 90 alpha family class A member 1 Homo sapiens 61-66 28822683-6 2017 ADP inhibition of human and yeast cytosolic Hsp90 can be relieved by the cochaperone aha1. Adenosine Diphosphate 0-3 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 44-49 28822683-6 2017 ADP inhibition of human and yeast cytosolic Hsp90 can be relieved by the cochaperone aha1. Adenosine Diphosphate 0-3 Aha1p Saccharomyces cerevisiae S288C 85-89 28822683-7 2017 ADP inhibition of bacterial Hsp90 can be relieved by bacterial Hsp70 and an activating client protein. Adenosine Diphosphate 0-3 heat shock protein 90 alpha family class A member 1 Homo sapiens 28-33 28822683-8 2017 These results suggest that altering ADP inhibition may be a mechanism of Hsp90 regulation. Adenosine Diphosphate 36-39 heat shock protein 90 alpha family class A member 1 Homo sapiens 73-78 28822683-11 2017 An accounting of ADP is critically important for designing and interpreting experiments with Hsp90. Adenosine Diphosphate 17-20 heat shock protein 90 alpha family class A member 1 Homo sapiens 93-98 28822683-12 2017 For example, contaminating ADP is a confounding factor in fluorescence resonance energy transfer experiments measuring arm closure rates of Hsp90. Adenosine Diphosphate 27-30 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 28822683-13 2017 Our observations suggest that ADP at physiological levels is important to Hsp90 structure, activity, and regulation. Adenosine Diphosphate 30-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 74-79 28504211-4 2017 Among these, adenine nucleotide translocase (ANT) is an ADP/ATP carrier but its role in controlling extracellular ADP levels and F1-ATPase-mediated HDL endocytosis has never been investigated. Adenosine Diphosphate 56-59 solute carrier family 25 member 6 Homo sapiens 45-48 28504211-4 2017 Among these, adenine nucleotide translocase (ANT) is an ADP/ATP carrier but its role in controlling extracellular ADP levels and F1-ATPase-mediated HDL endocytosis has never been investigated. Adenosine Diphosphate 114-117 solute carrier family 25 member 6 Homo sapiens 45-48 28504211-6 2017 We then showed that ecto-ANT activity increases or reduces extracellular ADP level, depending on the extracellular ADP/ATP ratio. Adenosine Diphosphate 73-76 solute carrier family 25 member 6 Homo sapiens 25-28 28504211-6 2017 We then showed that ecto-ANT activity increases or reduces extracellular ADP level, depending on the extracellular ADP/ATP ratio. Adenosine Diphosphate 115-118 solute carrier family 25 member 6 Homo sapiens 25-28 28504211-7 2017 Interestingly, ecto-ANT co-localized with ecto-F1-ATPase at the hepatocyte plasma membrane and pharmacological inhibition of ecto-ANT activity increased extracellular ADP level when ecto-F1-ATPase was activated by apoA-I. Adenosine Diphosphate 167-170 solute carrier family 25 member 6 Homo sapiens 20-23 28504211-7 2017 Interestingly, ecto-ANT co-localized with ecto-F1-ATPase at the hepatocyte plasma membrane and pharmacological inhibition of ecto-ANT activity increased extracellular ADP level when ecto-F1-ATPase was activated by apoA-I. Adenosine Diphosphate 167-170 solute carrier family 25 member 6 Homo sapiens 130-133 28504211-9 2017 This study thus uncovered a new location and function of ANT for which activity at the cell surface of hepatocytes modulates the concentration of extracellular ADP and regulates HDL endocytosis. Adenosine Diphosphate 160-163 solute carrier family 25 member 6 Homo sapiens 57-60 28829041-6 2017 Remarkably, testing of myocardial tissue from Mc4r-/- mice exhibited increased ADP stimulated respiratory capacity. Adenosine Diphosphate 79-82 melanocortin 4 receptor Mus musculus 46-50 28759073-1 2017 The ecto-nucleoside triphosphate diphosphohydrolase-1 (E-NTPDase-1, CD39) enzyme is responsible for the breakdown of extracellular ATP to ADP and then to AMP by a two-step process. Adenosine Diphosphate 138-141 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 4-53 28751543-5 2017 We sought to increase the platelet inhibitory potential by fusing GPVI-Fc to the ectonucleotidase CD39 (fusion protein GPVI-CD39), which inhibits local ADP accumulation at vascular plaques, and thus to create a lesion-directed dual antiplatelet therapy that is expected to lack systemic bleeding risks. Adenosine Diphosphate 152-155 glycoprotein VI platelet Homo sapiens 66-70 28751543-5 2017 We sought to increase the platelet inhibitory potential by fusing GPVI-Fc to the ectonucleotidase CD39 (fusion protein GPVI-CD39), which inhibits local ADP accumulation at vascular plaques, and thus to create a lesion-directed dual antiplatelet therapy that is expected to lack systemic bleeding risks. Adenosine Diphosphate 152-155 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 98-102 28751543-5 2017 We sought to increase the platelet inhibitory potential by fusing GPVI-Fc to the ectonucleotidase CD39 (fusion protein GPVI-CD39), which inhibits local ADP accumulation at vascular plaques, and thus to create a lesion-directed dual antiplatelet therapy that is expected to lack systemic bleeding risks. Adenosine Diphosphate 152-155 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 119-128 28751543-6 2017 METHODS AND RESULTS: GPVI-CD39 effectively stimulated local ADP degradation and, compared with GPVI-Fc alone, led to significantly increased inhibition of ADP-, collagen-, and human plaque-induced platelet aggregation in Multiplate aggregometry and plaque-induced platelet thrombus formation under arterial flow conditions. Adenosine Diphosphate 60-63 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 21-30 28751543-6 2017 METHODS AND RESULTS: GPVI-CD39 effectively stimulated local ADP degradation and, compared with GPVI-Fc alone, led to significantly increased inhibition of ADP-, collagen-, and human plaque-induced platelet aggregation in Multiplate aggregometry and plaque-induced platelet thrombus formation under arterial flow conditions. Adenosine Diphosphate 60-63 glycoprotein VI platelet Homo sapiens 21-25 28751543-6 2017 METHODS AND RESULTS: GPVI-CD39 effectively stimulated local ADP degradation and, compared with GPVI-Fc alone, led to significantly increased inhibition of ADP-, collagen-, and human plaque-induced platelet aggregation in Multiplate aggregometry and plaque-induced platelet thrombus formation under arterial flow conditions. Adenosine Diphosphate 155-158 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 21-30 28751543-6 2017 METHODS AND RESULTS: GPVI-CD39 effectively stimulated local ADP degradation and, compared with GPVI-Fc alone, led to significantly increased inhibition of ADP-, collagen-, and human plaque-induced platelet aggregation in Multiplate aggregometry and plaque-induced platelet thrombus formation under arterial flow conditions. Adenosine Diphosphate 155-158 glycoprotein VI platelet Homo sapiens 21-25 28742155-2 2017 For this purpose, we used a Dictyostelium G680V mutant myosin II whose release rates of Pi and ADP were highly suppressed relative to normal myosin, leading to a significantly extended life-time of the strongly bound state with actin and virtually no motility. Adenosine Diphosphate 95-98 myosin heavy chain 14 Homo sapiens 55-61 28449043-7 2017 The annealing activity of Mcm2~7 does not require Mg2+ and ATP, and is adversely inhibited by the presence of high concentration of Mg2+ and ATP while activated by similar concentrations of ADP. Adenosine Diphosphate 190-193 minichromosome maintenance complex component 2 Mus musculus 26-30 16219773-3 2006 Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules. Adenosine Diphosphate 143-146 Poly-(ADP-ribose) polymerase Drosophila melanogaster 68-72 16472655-2 2006 The C3 enzyme selectively catalyzes the ADP-ribosylation, and consequent inactivation, of RhoA, RhoB, and RhoC of the Rho GTPase protein family. Adenosine Diphosphate 40-43 ras homolog family member C Homo sapiens 106-110 16805423-7 2006 The P2Y1 antagonist MRS2500 inhibited ADP-induced human platelet aggregation with an IC50 of 0.95 nM. Adenosine Diphosphate 38-41 purinergic receptor P2Y1 Homo sapiens 4-8 15927298-0 2005 Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line. Adenosine Diphosphate 19-22 leptin Homo sapiens 0-6 15927298-9 2005 Leptin-potentiated increases in [Ca(2+)](i) induced by ADP. Adenosine Diphosphate 55-58 leptin Homo sapiens 0-6 15927298-13 2005 The results indicate that leptin enhances ADP-induced [Ca(2+)](i) increases via JAK2 and tyrosine kinases in a megakaryoblast cell line. Adenosine Diphosphate 42-45 leptin Homo sapiens 26-32 15955565-3 2005 The P2Y1 receptor is responsible for ADP-induced shape change and weak and transient aggregation, while the P2Y12 receptor is responsible for the completion and amplification of the response to ADP and to all platelet agonists, including thromboxane A2 (TXA2), thrombin, and collagen. Adenosine Diphosphate 37-40 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 4-17 15955565-3 2005 The P2Y1 receptor is responsible for ADP-induced shape change and weak and transient aggregation, while the P2Y12 receptor is responsible for the completion and amplification of the response to ADP and to all platelet agonists, including thromboxane A2 (TXA2), thrombin, and collagen. Adenosine Diphosphate 194-197 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 4-17 15955565-3 2005 The P2Y1 receptor is responsible for ADP-induced shape change and weak and transient aggregation, while the P2Y12 receptor is responsible for the completion and amplification of the response to ADP and to all platelet agonists, including thromboxane A2 (TXA2), thrombin, and collagen. Adenosine Diphosphate 194-197 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 108-113 16269922-5 2005 RESULTS: Alcohol consumption was inversely associated with P-selectin expression in response to 1 microm ADP (p = 0.007) and 5 microm ADP (p = 0.02) among men but not women. Adenosine Diphosphate 105-108 selectin P Homo sapiens 59-69 16269922-5 2005 RESULTS: Alcohol consumption was inversely associated with P-selectin expression in response to 1 microm ADP (p = 0.007) and 5 microm ADP (p = 0.02) among men but not women. Adenosine Diphosphate 134-137 selectin P Homo sapiens 59-69 15886225-2 2005 Because thrombus formation is a major cause of acute coronary events and leptin was shown previously to facilitate ADP-induced platelet aggregation, we chose to define the signaling events involved in leptin-mediated platelet activation. Adenosine Diphosphate 115-118 leptin Homo sapiens 73-79 16250859-2 2005 Engagement of GPIbalpha (the major ligand-binding subunit of GPIb-IX-V) by von Willebrand factor or GPVI by collagen, leads to mobilization of cytosolic Ca2+, secretion of platelet agonists such as ADP, cytoskeletal changes, and activation of the platelet integrin alphaIIbbeta3 that mediates von Willebrand factor- or fibrinogen-dependent platelet aggregation. Adenosine Diphosphate 198-201 glycoprotein VI platelet Homo sapiens 100-104 16129021-7 2005 Moreover, (S,S) PSRCDCR-NH(2) (peptide 11), one of the more active peptides, inhibited ADP-induced P-selectin exposure. Adenosine Diphosphate 87-90 selectin P Homo sapiens 99-109 16194206-4 2005 ADP alone, used as a primary agonist, activated Rac and its effector PAK via its P2Y1 receptor, through a G(q)-dependent pathway and independently of P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 81-94 15914557-0 2005 Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Adenosine Diphosphate 117-120 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 18-24 15914557-2 2005 We now demonstrate that the well-established synergy between P2Y(1) and P2Y(12) receptors during adenosine diphosphate (ADP)-dependent activation of the platelet alpha(IIb)beta(3) integrin also exists in murine marrow megakaryocytes, further supporting the progenitor cell as a bona fide model of platelet P2 receptor signaling. Adenosine Diphosphate 97-118 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 61-67 15914557-2 2005 We now demonstrate that the well-established synergy between P2Y(1) and P2Y(12) receptors during adenosine diphosphate (ADP)-dependent activation of the platelet alpha(IIb)beta(3) integrin also exists in murine marrow megakaryocytes, further supporting the progenitor cell as a bona fide model of platelet P2 receptor signaling. Adenosine Diphosphate 120-123 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 61-67 15914557-6 2005 Recordings in P2Y(1)-receptor-deficient megakaryocytes demonstrated an essential requirement of this receptor for activation of all ADP-evoked inward currents. Adenosine Diphosphate 132-135 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 14-29 15951390-6 2005 Our results are consistent with structural rearrangements in which there is an 8.5-A closure between the 344W residue and the mant moiety during the transition from the strongly (ADP) to weakly (ATP) actin-bound states of the myosin ATPase cycle. Adenosine Diphosphate 179-182 myosin heavy chain 14 Homo sapiens 226-232 16307036-2 2005 Cell P2X1 receptors exhibited a positive cooperative response to ADP (EC(50)=10.88+/-3.70 nM, Hill constant n=2.59+/-0.50 rel. Adenosine Diphosphate 65-68 purinergic receptor P2X 1 Homo sapiens 5-9 16307036-4 2005 Cooperative binding of ADP to platelet P2X1 receptors was also observed during incubation of cells from pregnant women with isosorbide dinitrate. Adenosine Diphosphate 23-26 purinergic receptor P2X 1 Homo sapiens 39-43 28428218-6 2017 Most importantly, patient platelets stimulated with ADP exhibited a marked increase in alphaIIbbeta3 integrin activation and a parallel increase in talin recruitment to beta3, contrasting with normal Rap1 activation. Adenosine Diphosphate 52-55 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 95-100 16178769-10 2005 In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. Adenosine Diphosphate 165-168 CD83 molecule Homo sapiens 105-109 28428218-6 2017 Most importantly, patient platelets stimulated with ADP exhibited a marked increase in alphaIIbbeta3 integrin activation and a parallel increase in talin recruitment to beta3, contrasting with normal Rap1 activation. Adenosine Diphosphate 52-55 RAP1A, member of RAS oncogene family Homo sapiens 200-204 16203679-2 2005 Two such conditions, autosomal dominant progressive external ophthalmoplegia (adPEO) and Senger"s Syndrome, are associated with dysfunction of the heart and muscle-specific isoform of the adenine nucleotide translocase (ANT1), a nDNA gene product that facilitates transport of ATP and ADP across the inner mitochondrial membrane. Adenosine Diphosphate 285-288 solute carrier family 25 member 4 Homo sapiens 220-224 27755650-8 2017 In conclusion, ADP exerts a dual role on ventricular myofibroblasts: [Ca2+ ]i transients are mediated by fast-desensitizing P2Y4 receptors, whereas the pro-fibrotic effect of ADP involves the P2Y1 receptor activation. Adenosine Diphosphate 15-18 pyrimidinergic receptor P2Y4 Rattus norvegicus 124-128 27830476-4 2017 Human CD39 rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine, an anti-thrombotic and cardiovascular protective mediator. Adenosine Diphosphate 38-41 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 6-10 16155414-5 2005 hGDH2 (nerve- specific GDH) was more sensitively affected by 1 mM ADP than hGDH1 (house-keeping GDH) on the activation by alkalized extracts. Adenosine Diphosphate 66-69 glutamate dehydrogenase 1 Homo sapiens 1-4 16155414-5 2005 hGDH2 (nerve- specific GDH) was more sensitively affected by 1 mM ADP than hGDH1 (house-keeping GDH) on the activation by alkalized extracts. Adenosine Diphosphate 66-69 glutamate dehydrogenase 1 Homo sapiens 23-26 16155414-6 2005 Studies with cassette mutagenesis at ADP-binding site showed that hGDH2 was more sensitively regulated by ADP than hGDH1 on the activation by Corydalis ternata. Adenosine Diphosphate 37-40 glutamate dehydrogenase 1 Homo sapiens 115-120 28317877-2 2017 As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Adenosine Diphosphate 205-226 solute carrier family 25 member 4 Homo sapiens 66-99 16023112-1 2005 When the influence of ADP-ribosylation on the activities of the purified human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) was measured in the presence of 100 microM NAD+ for 60 min, hGDH isozymes were inhibited by up to 75%. Adenosine Diphosphate 22-25 glutamate dehydrogenase 1 Homo sapiens 113-118 15657180-8 2005 However, ART2.2 itself was a prominent target for ADP-ribosylation only when GPI anchored. Adenosine Diphosphate 50-53 ADP-ribosyltransferase 2b Mus musculus 9-15 15657180-9 2005 Furthermore, cholesterol depletion or detergent solubilization abolished the auto-ADP-ribosylation of ART2.2. Adenosine Diphosphate 82-85 ADP-ribosyltransferase 2b Mus musculus 102-108 28317877-2 2017 As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Adenosine Diphosphate 205-226 solute carrier family 25 member 4 Homo sapiens 101-105 15647764-5 2005 The transgene ANT1 protein was targeted to the mitochondrion, was inserted into the mitochondrial inner membrane, formed a functional ADP/ATP carrier, increased the mitochondrial export of ATP and reversed the histopathological changes associated with the mitochondrial myopathy. Adenosine Diphosphate 134-137 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 14-18 28317877-2 2017 As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Adenosine Diphosphate 232-235 solute carrier family 25 member 4 Homo sapiens 66-99 28317877-2 2017 As the most abundant protein in the mitochondrial inner membrane, adenine nucleotide translocator 1 (ANT1) plays a critical role in mitochondrial function, including the exchange of adenosine triphosphate/adenosine diphosphate (ATP/ADP) in mitochondria, basal proton leak and mitochondrial permeability transition pore (mPTP). Adenosine Diphosphate 232-235 solute carrier family 25 member 4 Homo sapiens 101-105 27794497-2 2017 We entered this field in 1980 with the isolation of native UCP1 and then reported the amino acid sequence structure discovering a strong homology to the ADP/ATP carrier. Adenosine Diphosphate 153-156 uncoupling protein 1 Homo sapiens 59-63 15772061-6 2005 The in vitro ADP-induced platelet aggregation and the expression of CD62P on ADP-stimulated platelets significantly increased in sedentary but not in active subjects. Adenosine Diphosphate 13-16 selectin P Homo sapiens 68-73 15772061-6 2005 The in vitro ADP-induced platelet aggregation and the expression of CD62P on ADP-stimulated platelets significantly increased in sedentary but not in active subjects. Adenosine Diphosphate 77-80 selectin P Homo sapiens 68-73 15767295-9 2005 Using the DeltaR-CFTR construct, we studied the inhibitory effect of ADP on CFTR gating. Adenosine Diphosphate 69-72 cystic fibrosis transmembrane conductance regulator Cricetulus griseus 76-80 27629990-5 2017 The most ubiquitous effect of all agonists (especially of ATP and ADP) appears to be the facilitation of cell proliferation, usually through P2Y1Rs and sometimes through P2X7Rs. Adenosine Diphosphate 66-69 purinergic receptor P2Y1 Homo sapiens 141-145 15733062-4 2005 Pre-incubation of human platelets with either an anti-Gas6 antibody or blocking antibodies to Sky or Mer inhibited platelet aggregation and degranulation responses to both ADP and the PAR-1 activating peptide, SFLLRN, by more than 80%. Adenosine Diphosphate 172-175 growth arrest specific 6 Homo sapiens 54-58 15766878-3 2005 The chimeric carrier, Anc2-Cyc1(His6)p, was able to restore growth on a non-fermentable carbon source of a yeast strain devoid of functional ADP/ATP carrier, which demonstrated its transport activity. Adenosine Diphosphate 141-144 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 27-31 15766878-6 2005 Purification of Anc2-Cyc1(His6)p in complex with carboxyatractyloside (CATR), a high affinity inhibitor of ADP/ATP transport, was achieved by combining ion-exchange chromatography and ion-metal affinity chromatography in the presence of LAPAO, an aminoxide detergent. Adenosine Diphosphate 107-110 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 21-25 15766878-8 2005 Large-scale purification of Anc2-Cyc1(His6)p-CATR complex opens up novel possibilities for the use of crystallographic approaches to the yeast ADP/ATP carrier. Adenosine Diphosphate 143-146 cytochrome c isoform 1 Saccharomyces cerevisiae S288C 33-37 15852220-1 2005 Platelets possess three P2 receptors: two (P2Y (1) and P2Y (12)) are receptors for adenosine diphosphate (ADP), and one (P2X1) is a receptor for adenosine triphosphate (ATP). Adenosine Diphosphate 83-104 purinergic receptor P2Y1 Homo sapiens 43-50 27861892-4 2017 The increased ANT1 level leads to accelerated ATP-ADP exchange rate, more Ca2+ -induced mitochondrial permeability transition pore opening, increased cytochrome c release, and eventually cell apoptosis. Adenosine Diphosphate 50-53 solute carrier family 25 member 4 Homo sapiens 14-18 15852220-1 2005 Platelets possess three P2 receptors: two (P2Y (1) and P2Y (12)) are receptors for adenosine diphosphate (ADP), and one (P2X1) is a receptor for adenosine triphosphate (ATP). Adenosine Diphosphate 106-109 purinergic receptor P2Y1 Homo sapiens 43-50 15852220-2 2005 The P2Y (1) receptor, which is coupled to Gq and phospholipase C-beta, is responsible for mobilization of ionized calcium from internal stores and mediates the ADP-induced platelet shape change and initial wave of rapidly reversible aggregation. Adenosine Diphosphate 160-163 purinergic receptor P2Y1 Homo sapiens 4-11 15852220-5 2005 The combined action of P2Y (1) and P2Y (12) is necessary for the full platelet aggregation response to ADP. Adenosine Diphosphate 103-106 purinergic receptor P2Y1 Homo sapiens 23-30 27863418-0 2016 Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization. Adenosine Diphosphate 17-20 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 0-4 15945611-5 2005 Platelet pre-incubation with leptin led to a significant and dose-dependent increase in ADP-induced platelet aggregation. Adenosine Diphosphate 88-91 leptin Homo sapiens 29-35 15602005-2 2005 In platelets and in transfected cells, exposure to 10 microM ADP caused desensitization of the P2Y1 receptor-driven calcium signal, whereas the P2Y12 receptor-mediated inhibition of cAMP formation was not affected. Adenosine Diphosphate 61-64 purinergic receptor P2Y1 Homo sapiens 95-108 27863418-0 2016 Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization. Adenosine Diphosphate 17-20 purinergic receptor P2Y1 Homo sapiens 74-78 15709756-0 2005 The characteristics of the (alpha V371C)3(beta R337C)3 gamma double mutant subcomplex of the TF1-ATPase indicate that the catalytic site at the alpha TP-beta TP interface with bound MgADP in crystal structures of MF1 represents a catalytic site containing inhibitory MgADP. Adenosine Diphosphate 182-187 flap structure-specific endonuclease 1 Homo sapiens 213-216 27165280-6 2016 Pras 5 mg reduced both ADP-stimulated platelet P-selectin and activated GPIIb-IIIa in VE (p < 0.01 for both analyses) and NE (p < 0.001 and p < 0.05, respectively). Adenosine Diphosphate 23-26 selectin P Homo sapiens 47-57 15709756-0 2005 The characteristics of the (alpha V371C)3(beta R337C)3 gamma double mutant subcomplex of the TF1-ATPase indicate that the catalytic site at the alpha TP-beta TP interface with bound MgADP in crystal structures of MF1 represents a catalytic site containing inhibitory MgADP. Adenosine Diphosphate 267-272 flap structure-specific endonuclease 1 Homo sapiens 213-216 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Adenosine Diphosphate 82-85 myosin heavy chain 14 Homo sapiens 99-105 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Adenosine Diphosphate 193-196 myosin heavy chain 14 Homo sapiens 99-105 15699260-3 2005 Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) is a key enzyme involved in vascular ADP metabolism. Adenosine Diphosphate 96-99 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 0-46 15699260-3 2005 Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) is a key enzyme involved in vascular ADP metabolism. Adenosine Diphosphate 96-99 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 48-57 27480079-5 2016 Adenosine diphosphate (ADP) was used to stimulate the P2Y1/P2Y12 pathway of platelet activation to mimic the in vivo thrombogenic pathway. Adenosine Diphosphate 0-21 purinergic receptor P2Y1 Homo sapiens 54-58 27480079-5 2016 Adenosine diphosphate (ADP) was used to stimulate the P2Y1/P2Y12 pathway of platelet activation to mimic the in vivo thrombogenic pathway. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 54-58 27480079-6 2016 Platelet aggregation studies utilised both ADP and collagen as exogenous platelet agonists to target both P2Y1/P2Y12 and GPVI pathways of thrombus formation. Adenosine Diphosphate 43-46 purinergic receptor P2Y1 Homo sapiens 106-110 27494025-3 2016 For dimeric myosin, an additional forward strain on the trailing head, originating from the postponed powerstroke state of the leading head in the waiting state of myosin, further increases the rate of ADP release. Adenosine Diphosphate 202-205 myosin heavy chain 14 Homo sapiens 12-18 27494025-3 2016 For dimeric myosin, an additional forward strain on the trailing head, originating from the postponed powerstroke state of the leading head in the waiting state of myosin, further increases the rate of ADP release. Adenosine Diphosphate 202-205 myosin heavy chain 14 Homo sapiens 164-170 27141100-2 2016 Increases in AMP:ATP and ADP:ATP ratios, signifying energy deficit, promote allosteric activation and net Thr172 phosphorylation mediated by LKB1, so that the LKB1-AMPK pathway acts as an energy sensor. Adenosine Diphosphate 25-28 serine/threonine kinase 11 Homo sapiens 141-145 27141100-2 2016 Increases in AMP:ATP and ADP:ATP ratios, signifying energy deficit, promote allosteric activation and net Thr172 phosphorylation mediated by LKB1, so that the LKB1-AMPK pathway acts as an energy sensor. Adenosine Diphosphate 25-28 serine/threonine kinase 11 Homo sapiens 159-163 27273580-6 2016 The ADP dissociation rate from acto-At myosin XI-I was 17 s(-1), accounting for the low actin-sliding velocity. Adenosine Diphosphate 4-7 myosin Arabidopsis thaliana 39-45 27384918-7 2016 Moreover, MRS2179, a specific antagonist of the P2Y1 receptor, abolished ADP response. Adenosine Diphosphate 73-76 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 48-61 27144942-3 2016 Activation of P2Y1 receptors by ADP (100 microM) or glutamatergic receptors by AMPA (0.3 microM) resulted in a robust, reversible and repeatable rise of evoked inhibitory input in Purkinje cells by 80% and 150%, respectively. Adenosine Diphosphate 32-35 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 14-18 27256882-5 2016 Depletion or inhibition of PARP-1 or mutation of the ADP-ribosylation sites on NELF-E promotes Pol II pausing, providing a clear functional link between PARP-1, ADP-ribosylation, and NELF. Adenosine Diphosphate 53-56 negative elongation factor complex member E Homo sapiens 79-85 27256882-5 2016 Depletion or inhibition of PARP-1 or mutation of the ADP-ribosylation sites on NELF-E promotes Pol II pausing, providing a clear functional link between PARP-1, ADP-ribosylation, and NELF. Adenosine Diphosphate 161-164 negative elongation factor complex member E Homo sapiens 79-85 27003103-5 2016 When ATP is present, complexes containing single-chain ClpX assemble via an intermediate and remain intact until transferred into buffers containing ADP or no nucleotides. Adenosine Diphosphate 149-152 caseinolytic mitochondrial matrix peptidase chaperone subunit X Homo sapiens 55-59 27059856-6 2016 Despite being monomeric, the N-terminal region of Smchd1 exhibits ATPase activity, which can be antagonized by the reaction product, ADP, or the Hsp90 inhibitor, radicicol, at a nanomolar concentration. Adenosine Diphosphate 133-136 structural maintenance of chromosomes flexible hinge domain containing 1 Homo sapiens 50-56 26945064-6 2016 Our data suggest that the WT embryonic myosin motor is similar in contractile speed to the slow type I/beta cardiac based on the rate constant for ADP release and ADP affinity for actin-myosin. Adenosine Diphosphate 147-150 myosin heavy chain 14 Homo sapiens 39-45 15681228-7 2005 The myosin head has a smaller but still detectable impact on this flexibility, since the addition of ADP to the rigor crossbridge produces differential effects on the torsional characteristics of double-headed versus single-headed myosin. Adenosine Diphosphate 101-104 myosin heavy chain 14 Homo sapiens 4-10 15681228-7 2005 The myosin head has a smaller but still detectable impact on this flexibility, since the addition of ADP to the rigor crossbridge produces differential effects on the torsional characteristics of double-headed versus single-headed myosin. Adenosine Diphosphate 101-104 myosin heavy chain 14 Homo sapiens 231-237 15691486-1 2005 In the mitochondrial internal membrane, the adenine nucleotide translocator (ANT) carries out the ATP/ADP exchange between cytoplasm and mitochondrial matrix. Adenosine Diphosphate 102-105 solute carrier family 25 member 6 Homo sapiens 44-75 15691486-1 2005 In the mitochondrial internal membrane, the adenine nucleotide translocator (ANT) carries out the ATP/ADP exchange between cytoplasm and mitochondrial matrix. Adenosine Diphosphate 102-105 solute carrier family 25 member 6 Homo sapiens 77-80 15711749-8 2005 Furthermore, cGKI inhibited ADP-induced Rap 1 activation induced by the Galpha(i)-coupled P2Y12 receptor alone, i.e. independently of effects on Ca2+-signalling. Adenosine Diphosphate 28-31 protein kinase cGMP-dependent 1 Homo sapiens 13-17 15711749-8 2005 Furthermore, cGKI inhibited ADP-induced Rap 1 activation induced by the Galpha(i)-coupled P2Y12 receptor alone, i.e. independently of effects on Ca2+-signalling. Adenosine Diphosphate 28-31 RAP1A, member of RAS oncogene family Homo sapiens 40-45 15670820-5 2005 Consistent with its belonging to the AAC subfamily, upon heterologous expression and reconstitution into liposomes AAC4 exchanges ADP for ATP by an electrogenic antiport mechanism with high specificity and high sensitivity to carboxyatractyloside and bongkrekic acid. Adenosine Diphosphate 130-133 solute carrier family 25 member 31 Homo sapiens 115-119 15684411-7 2005 Furthermore, Poa1p is strongly inhibited by ADP-ribose (K(I), 17 microM), modestly inhibited by other nucleotides containing an ADP-ribose moiety and not inhibited at all by other tested molecules. Adenosine Diphosphate 44-47 ADP-ribose 1''-phosphate phosphatase Saccharomyces cerevisiae S288C 13-18 15652174-1 2005 Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme that hydrolyzes ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0. Adenosine Diphosphate 154-157 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 26-33 15652174-1 2005 Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme that hydrolyzes ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0. Adenosine Diphosphate 154-157 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 35-44 15652174-1 2005 Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme that hydrolyzes ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0. Adenosine Diphosphate 154-157 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 46-58 15652174-1 2005 Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme that hydrolyzes ATP and ADP and also other di- and triphosphate nucleosides, acting at an optimum pH of 8.0. Adenosine Diphosphate 154-157 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 85-89 15652174-3 2005 NTPDase inhibitors, 20 mM sodium fluoride, 0.2 mM trifluoperazine and 0.3 mM suramin, significantly decreased ATP and ADP hydrolysis (P<0.05) and ADP hydrolysis was only inhibited by 0.5 mM orthovanadate (P<0.05). Adenosine Diphosphate 118-121 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-7 15652174-3 2005 NTPDase inhibitors, 20 mM sodium fluoride, 0.2 mM trifluoperazine and 0.3 mM suramin, significantly decreased ATP and ADP hydrolysis (P<0.05) and ADP hydrolysis was only inhibited by 0.5 mM orthovanadate (P<0.05). Adenosine Diphosphate 149-152 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-7 15652174-9 2005 The study of NTPDase activity in human lymphocytes may be important to determine the immune response status against infectious agents related to ATP and ADP hydrolysis. Adenosine Diphosphate 153-156 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 13-20 15528188-6 2005 Megakaryocytes from P2Y1(-/-) mice lacked voltage-dependent Ca2+ release during the application of ADP but retained this response after stimulation of other Galphaq-coupled receptors. Adenosine Diphosphate 99-102 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 20-24 15912207-7 2005 ADP-dependent platelet aggregation is initiated by the P2Y1 receptor, whereas P2Y(12) receptor augments the activating signal and promotes platelet release reaction. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 55-68 15514209-0 2005 Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 18-22 15514209-8 2005 A P2Y1 gene dimorphism, 1622AG, was associated with a significant (P=0.007) effect on platelet ADP response, with a greater response in carriers of the G allele (frequency 0.15). Adenosine Diphosphate 95-98 purinergic receptor P2Y1 Homo sapiens 2-6 26945064-6 2016 Our data suggest that the WT embryonic myosin motor is similar in contractile speed to the slow type I/beta cardiac based on the rate constant for ADP release and ADP affinity for actin-myosin. Adenosine Diphosphate 163-166 myosin heavy chain 14 Homo sapiens 39-45 15514209-10 2005 CONCLUSIONS: A common genetic variant at the P2Y1 locus is associated with platelet reactivity to ADP. Adenosine Diphosphate 98-101 purinergic receptor P2Y1 Homo sapiens 45-49 27055904-2 2016 The P2Y12 receptor mediates ADP-induced aggregation and secretion in platelets. Adenosine Diphosphate 28-31 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 4-9 15761165-3 2005 ADP body fat content was estimated from body density (Db) using equations devised by Siri (ADP(Siri)) and Lohman (ADP(Loh)). Adenosine Diphosphate 0-3 WD and tetratricopeptide repeats 1 Homo sapiens 91-100 26939705-6 2016 In summary, H89 increased RIT activity by enhancing the two key events: ADP-ribosylation of eEF2 and reduction of MCL1 levels. Adenosine Diphosphate 72-75 eukaryotic translation elongation factor 2 Homo sapiens 92-96 15231520-5 2004 Exogenous ADP partly restored the suppressive effect of GPVI blockade on integrin alpha2beta1 and alphaIIbbeta3 activation. Adenosine Diphosphate 10-13 glycoprotein VI platelet Homo sapiens 56-60 15231520-8 2004 CONCLUSIONS: GPVI- and autocrine-released ADP induce affinity changes of alpha2beta1 and alphaIIbbeta3 during thrombus formation on collagen under flow. Adenosine Diphosphate 42-45 glycoprotein VI platelet Homo sapiens 13-17 26953339-7 2016 However, the position of the N-domain modules relative to the AAA domains in the Msm0858-ADP tertiary structure is different and would impede the formation of a p97-like hexameric quaternary structure. Adenosine Diphosphate 89-92 melanotransferrin Homo sapiens 161-164 15287721-0 2004 Disparity in allosteric interactions of monastrol with Eg5 in the presence of ADP and ATP: a difference FT-IR investigation. Adenosine Diphosphate 78-81 kinesin family member 11 Homo sapiens 55-58 15287721-4 2004 Utilizing a truncated Eg5 protein, we employ difference infrared spectroscopy to probe structural changes that occur in the motor protein with monastrol in the presence of either ADP or ATP. Adenosine Diphosphate 179-182 kinesin family member 11 Homo sapiens 22-25 15287721-7 2004 In Eg5-monastrol complexes, exchange of ADP is associated with a decrease in random structure and an increase in alpha-helical content. Adenosine Diphosphate 40-43 kinesin family member 11 Homo sapiens 3-6 26934315-1 2016 Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and are involved in a variety of biological processes. Adenosine Diphosphate 6-9 poly(ADP-ribose) polymerase family member 6 Homo sapiens 31-36 15287721-9 2004 One or more carboxylic acid residues in Eg5 undergo unique changes when ATP, but not ADP, interacts with the motor domain in the presence of monastrol. Adenosine Diphosphate 85-88 kinesin family member 11 Homo sapiens 40-43 15296636-3 2004 The assay is based on the competition of fluorescently (BODIPY) labeled geldanamycin (GM) for binding to purified recombinant Hsp90alpha (GM is a natural product that binds to the ATP/ADP pocket in the amino terminal of Hsp90). Adenosine Diphosphate 184-187 heat shock protein 90 alpha family class A member 1 Homo sapiens 126-136 15296636-3 2004 The assay is based on the competition of fluorescently (BODIPY) labeled geldanamycin (GM) for binding to purified recombinant Hsp90alpha (GM is a natural product that binds to the ATP/ADP pocket in the amino terminal of Hsp90). Adenosine Diphosphate 184-187 heat shock protein 90 alpha family class A member 1 Homo sapiens 126-131 26976594-0 2016 Force-producing ADP state of myosin bound to actin. Adenosine Diphosphate 16-19 myosin heavy chain 14 Homo sapiens 29-35 15296636-7 2004 GM, PU24FCl, ADP, and ATP, all known to bind to the Hsp90 pocket, compete with GM-BODIPY for binding to Hsp90alpha with EC(50)s in agreement with reported values. Adenosine Diphosphate 13-16 heat shock protein 90 alpha family class A member 1 Homo sapiens 52-57 15054038-5 2004 Platelet activation by HOCl-LDL and ADP (1 microM) caused P-selectin (CD62P) exposure, without serotonin or adenosine triphosphate (ATP) secretion. Adenosine Diphosphate 36-39 selectin P Homo sapiens 58-68 15054038-5 2004 Platelet activation by HOCl-LDL and ADP (1 microM) caused P-selectin (CD62P) exposure, without serotonin or adenosine triphosphate (ATP) secretion. Adenosine Diphosphate 36-39 selectin P Homo sapiens 70-75 15240503-5 2004 The second model, which assumes the direct transfer of substrates between MiCK and ANT, is shown to be in good agreement with experiments--i.e., the second model reproduced the measured constants and the estimated ADP flux, entering mitochondria after the MiCK reaction. Adenosine Diphosphate 214-217 solute carrier family 25 member 6 Homo sapiens 83-86 15305227-7 2004 Previously, we detected a significant correlation between prolactin values and ADP-stimulated P-selectin expression on platelets in pregnant women, patients with pituitary tumours, and patients on anti-psychotic therapy. Adenosine Diphosphate 79-82 selectin P Homo sapiens 94-104 15305227-11 2004 Moreover, our data suggest that the stronger effect of prolactin on ADP-stimulated platelet aggregation, compared to leptin, depends on higher stimulation of CD62p expression by prolactin. Adenosine Diphosphate 68-71 selectin P Homo sapiens 158-163 16120388-4 2004 The Vpr/ANT interaction is direct, since it is abolished by the addition of a peptide corresponding to the Vpr binding site of ANT, ADP, ATP, or by Bcl-2. Adenosine Diphosphate 132-135 solute carrier family 25 member 6 Homo sapiens 8-11 15199230-5 2004 Studies using single muscle fibers at room temperature or lower have shown that myosin motor function is inhibited by the accumulation of the ATP-hydrolysis products ADP, Pi, and H+ as well as by excess generation of reactive oxygen species (ROS). Adenosine Diphosphate 166-169 myosin heavy chain 14 Homo sapiens 80-86 15034156-6 2004 Platelet reactivity was assessed with the use of flow cytometry by determining the capacity of platelets to bind fibrinogen and the surface expression of P-selectin in response to adenosine diphosphate (ADP, 0 and 0.2 microM). Adenosine Diphosphate 180-201 selectin P Homo sapiens 154-164 15034156-6 2004 Platelet reactivity was assessed with the use of flow cytometry by determining the capacity of platelets to bind fibrinogen and the surface expression of P-selectin in response to adenosine diphosphate (ADP, 0 and 0.2 microM). Adenosine Diphosphate 203-206 selectin P Homo sapiens 154-164 14645014-8 2004 These results indicate a central role for ADP-mediated P2Y1 and P2Y12 receptor activation in supporting LPA-induced platelet aggregation. Adenosine Diphosphate 42-45 purinergic receptor P2Y1 Homo sapiens 55-59 15044002-6 2004 Both hGDH1 and hGDH2, however, showed much slower heat inactivation processes in the presence of 1 mM ADP or 3 mM L-Leu. Adenosine Diphosphate 102-105 glutamate dehydrogenase 1 Homo sapiens 5-10 15381386-6 2004 Clopidogrel treatment inhibited ADP-induced platelet P-selectin expression by 72% (54-85%). Adenosine Diphosphate 32-35 selectin P Homo sapiens 53-63 12842985-8 2003 A residual GPVI signal exists in the Btk-/-/Tec-/- platelets as CRP synergizes with ADP to mediate aggregation. Adenosine Diphosphate 84-87 glycoprotein VI platelet Homo sapiens 11-15 12891704-5 2003 The 97 kDa species was identified as eEF2, because it was (1) recognized by a polyclonal antiserum specific for eEF2, (2) ADP-ribosylated by diphtheria toxin (DT), and (3) radiolabeled by gamma-32P-azido-GTP and UV-irradiation. Adenosine Diphosphate 122-125 eukaryotic translation elongation factor 2 Homo sapiens 37-41 12796499-5 2003 U46619 stimulated phosphoinositide 3-kinase (PI3K)-dependent phosphorylation of Akt, which was augmented by ADP but did not require integrin outside-in signaling. Adenosine Diphosphate 108-111 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 18-43 12897207-1 2003 The critical role for ADP in arterial thrombogenesis was established by the clinical success of P2Y12 antagonists, currently used at doses that block 40-50% of the P2Y12 on platelets. Adenosine Diphosphate 22-25 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 96-101 12897207-1 2003 The critical role for ADP in arterial thrombogenesis was established by the clinical success of P2Y12 antagonists, currently used at doses that block 40-50% of the P2Y12 on platelets. Adenosine Diphosphate 22-25 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 164-169 12704400-10 2003 CONCLUSIONS: Leptin produces a dose-dependent enhancement of ADP-induced platelet aggregation in humans. Adenosine Diphosphate 61-64 leptin Homo sapiens 13-19 12717012-5 2003 Competition studies with ClpX and fluorescently labeled ADP gave inhibition constants for ATPgammaS ( approximately 2 micro M) and ADP ( approximately 3 micro M) under the reaction conditions used for steady-state kinetics. Adenosine Diphosphate 131-134 caseinolytic mitochondrial matrix peptidase chaperone subunit X Homo sapiens 25-29 12653548-0 2003 Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation. Adenosine Diphosphate 22-25 glutamate dehydrogenase 1 Homo sapiens 50-73 12653548-2 2003 Unlike GDH from bacteria, mammalian GDH exhibits negative cooperativity with respect to coenzyme, activation by ADP, and inhibition by GTP. Adenosine Diphosphate 112-115 glutamate dehydrogenase 1 Homo sapiens 36-39 12653548-3 2003 Presented here are the structures of apo bovine GDH, bovine GDH complexed with ADP, and the R463A mutant form of human GDH (huGDH) that is insensitive to ADP activation. Adenosine Diphosphate 79-82 glutamate dehydrogenase 1 Homo sapiens 60-63 12653548-8 2003 The structure of the ADP-resistant, R463A mutant of human GDH is identical to native GDH with the exception of the truncated side chain on the pivot helix. Adenosine Diphosphate 21-24 glutamate dehydrogenase 1 Homo sapiens 58-61 12653548-8 2003 The structure of the ADP-resistant, R463A mutant of human GDH is identical to native GDH with the exception of the truncated side chain on the pivot helix. Adenosine Diphosphate 21-24 glutamate dehydrogenase 1 Homo sapiens 85-88 12595918-1 2003 MRS-2179 is a selective P2Y(1) receptor antagonist, a strong inhibitor of ADP-induced platelet aggregation in vitro and ex vivo. Adenosine Diphosphate 74-77 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 24-39 12475792-1 2002 Autoantibodies against CD38 (adenosine-5"-diphosphate[ADP]-ribosyl cyclase/cyclic ADP-ribose hydrolase) have been described in 10-12% of patients with type 2 diabetes. Adenosine Diphosphate 29-53 CD38 molecule Homo sapiens 23-27 12475792-1 2002 Autoantibodies against CD38 (adenosine-5"-diphosphate[ADP]-ribosyl cyclase/cyclic ADP-ribose hydrolase) have been described in 10-12% of patients with type 2 diabetes. Adenosine Diphosphate 54-57 CD38 molecule Homo sapiens 23-27 26976594-2 2016 For myosin motors, the primary force-generating state has MgADP tightly bound, whereas myosin is strongly bound to actin. Adenosine Diphosphate 58-63 myosin heavy chain 14 Homo sapiens 4-10 26976594-7 2016 The transition from the force-generating ADP state to Rigor requires a 9.5 rotation of the myosin lever arm, coupled to a beta-sheet rearrangement. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 92-98 12324473-0 2002 Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 1 Homo sapiens 80-85 26950455-5 2016 PAR-1 antagonist SCH-79797 inhibited platelet aggregation as well as decreased platelet P-selectin expression induced by ADP. Adenosine Diphosphate 121-124 selectin P Homo sapiens 88-98 12324473-0 2002 Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 1 Homo sapiens 87-110 12324473-5 2002 The R443S mutant was much less sensitive to ADP (SC(50) = 383.9 +/- 14.6 microm) than the GLUD1 GDH (SC(50) = 31.7 +/- 4.2 microm; p < 0.001); however, at 1 mm ADP the V(max) for the mutant (136.67 micromol min(-1) mg(-1)) was comparable with that of the GLUD1 GDH (152.95 micromol min(-1) mg(-1)). Adenosine Diphosphate 44-47 glutamate dehydrogenase 1 Homo sapiens 258-263 12324473-5 2002 The R443S mutant was much less sensitive to ADP (SC(50) = 383.9 +/- 14.6 microm) than the GLUD1 GDH (SC(50) = 31.7 +/- 4.2 microm; p < 0.001); however, at 1 mm ADP the V(max) for the mutant (136.67 micromol min(-1) mg(-1)) was comparable with that of the GLUD1 GDH (152.95 micromol min(-1) mg(-1)). Adenosine Diphosphate 44-47 glutamate dehydrogenase 1 Homo sapiens 264-267 26808867-3 2016 OBJECTIVES: Since ADP mediates its effects via three purinergic receptors P2Y1, P2X1 and P2Y12, their surface expression and function were investigated in washed platelets and, for comparison, in platelet-rich-plasma (PRP) at different time points for up to 2 hours after preparation. Adenosine Diphosphate 18-21 purinergic receptor P2Y1 Homo sapiens 74-78 26808867-3 2016 OBJECTIVES: Since ADP mediates its effects via three purinergic receptors P2Y1, P2X1 and P2Y12, their surface expression and function were investigated in washed platelets and, for comparison, in platelet-rich-plasma (PRP) at different time points for up to 2 hours after preparation. Adenosine Diphosphate 18-21 purinergic receptor P2X 1 Homo sapiens 80-84 26808867-8 2016 CONCLUSION: In conclusion, decreasing ADP responsiveness in washed platelets is particularly caused by impaired activity of the P2Y1 receptor associated with disturbed calcium regulation, which has to be considered in the design of experimental studies addressing ADP mediated platelet function. Adenosine Diphosphate 38-41 purinergic receptor P2Y1 Homo sapiens 128-141 12414103-4 2002 8-OH-DPAT-induced suppression of the mAHP and enhancement of the ADP were also antagonized by a protein kinase A (PKA) inhibitor H89, whereas 8-OH-DPAT could inhibit the mAHP and enhance the ADP in the presence of a protein kinase C (PKC) inhibitor chelerythrine. Adenosine Diphosphate 65-68 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 96-112 12414103-4 2002 8-OH-DPAT-induced suppression of the mAHP and enhancement of the ADP were also antagonized by a protein kinase A (PKA) inhibitor H89, whereas 8-OH-DPAT could inhibit the mAHP and enhance the ADP in the presence of a protein kinase C (PKC) inhibitor chelerythrine. Adenosine Diphosphate 65-68 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 114-117 12176731-4 2002 We increased the ADP-producing activity in rat heart skinned fiber bundles by incubating with 100 IU/ml yeast hexokinase and glucose. Adenosine Diphosphate 17-20 hexokinase Saccharomyces cerevisiae S288C 110-120 26808867-8 2016 CONCLUSION: In conclusion, decreasing ADP responsiveness in washed platelets is particularly caused by impaired activity of the P2Y1 receptor associated with disturbed calcium regulation, which has to be considered in the design of experimental studies addressing ADP mediated platelet function. Adenosine Diphosphate 264-267 purinergic receptor P2Y1 Homo sapiens 128-141 12323373-5 2002 Monastrol appears to inhibit microtubule-stimulated ADP release from Eg5 but does not compete with microtubule binding, suggesting that monastrol binds a novel allosteric site in the motor domain. Adenosine Diphosphate 52-55 kinesin family member 11 Homo sapiens 69-72 27069920-6 2016 Our results show that P2Y1 receptor stimulation with ADP-induced calcium influx was inhibited by APDs in human and rats" platelets, as assessed by in vitro or ex vivo approach, respectively. Adenosine Diphosphate 53-56 purinergic receptor P2Y1 Homo sapiens 22-35 12204118-4 2002 The FRETs for the myosin.ADP.AlF4- and myosin.ADP.BeFn ternary complexes, which mimic the M*.ADP.P(i) state and M.ATP state in the ATPase cycle, respectively, were similar to that of NBD-ATP. Adenosine Diphosphate 25-28 myosin heavy chain 14 Homo sapiens 18-24 12231375-9 2002 The energetic charge (EC = [(0.5 adenosine diphosphate + adenosine triphosphate) / (adenosine triphosphate + adenosine diphosphate + adenosine monophosphate)]) in STH-2, UW, HTK, STF, EC, and saline groups was significantly lower (p < 0.05) than in the other groups. Adenosine Diphosphate 33-54 sulfotransferase family 2A member 1 Rattus norvegicus 163-168 26307000-2 2016 Ectonucleotidase CD39 hydrolyses ATP and ADP. Adenosine Diphosphate 41-44 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 17-21 12271274-13 2002 Endogenous CD39 may thus have a hemostatic function by promoting ADP formation from released ATP, in addition to its antiaggregatory properties. Adenosine Diphosphate 65-68 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 11-15 26733870-3 2015 We hypothesized that ADP-induced contraction (rigor) of smaller length microbiopsy PmFB causes a greater reduction in maximal respiration vs. Bergstrom, such that respiration could be increased by a myosin II ATPase-inhibitor (Blebbistatin; BLEB). Adenosine Diphosphate 21-24 myosin heavy chain 14 Homo sapiens 199-205 12181428-4 2002 Stable expression of the P2Y(1)-NTPDase1 fusion protein conferred an ADP and 2MeSADP-promoted Ca(2+) response to CHO-K1 cells. Adenosine Diphosphate 69-72 purinergic receptor P2Y1 Homo sapiens 25-40 12353080-0 2002 Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Adenosine Diphosphate 14-17 selectin P Homo sapiens 26-36 26733870-10 2015 These findings suggest that smaller diameter percutaneous biopsies yield lower glutamate-supported mitochondrial respiratory kinetics which is increased by preventing ADP-induced rigor with myosin inhibition. Adenosine Diphosphate 167-170 myosin heavy chain 14 Homo sapiens 190-196 26662400-3 2015 CD62p and PAC-1 were higher in the ALL group before adenosine-5-diphosphate (ADP) activation than in the normal group (P < 0.05); PAC-1 expression was higher and lower in the ALL-CR1 group than in normal and ALL groups (P < 0.05), respectively. Adenosine Diphosphate 52-75 selectin P Homo sapiens 0-5 11950837-6 2002 The catalytic and kinetic properties of the G456A mutant and its activation by ADP were comparable with those of the wild type GDH. Adenosine Diphosphate 79-82 glutamate dehydrogenase 1 Homo sapiens 127-130 26662400-3 2015 CD62p and PAC-1 were higher in the ALL group before adenosine-5-diphosphate (ADP) activation than in the normal group (P < 0.05); PAC-1 expression was higher and lower in the ALL-CR1 group than in normal and ALL groups (P < 0.05), respectively. Adenosine Diphosphate 77-80 selectin P Homo sapiens 0-5 12355033-5 2002 Platelet reactivity was characterized with flow cytometry to quantify the percentage of platelets capable of binding fibrinogen (activation of glycoprotein IIb-IIIa) and expressing P-selectin in response to adenosine diphosphate (ADP, 0, 0.2, and 1 microM). Adenosine Diphosphate 207-228 selectin P Homo sapiens 181-191 12355033-7 2002 Platelet reactivity was greater in blood treated with UFH than in blood exposed to enoxaparin with respect to P-selectin expression (by 7 +/- 1.1%, p, < 0.0001) in response to 1 microM ADP. Adenosine Diphosphate 188-191 selectin P Homo sapiens 110-120 26662400-4 2015 CD62p and PAC-1 expression was lower in the ALL group than in the normal group after ADP activation (P < 0.05); PAC-1 expression was lower and higher in the ALL-CR1 group than in normal and ALL groups, respectively (P < 0.05). Adenosine Diphosphate 85-88 selectin P Homo sapiens 0-5 12189027-5 2002 In this study, flow cytometric analysis of washed platelets from five healthy adult volunteers demonstrated TF-antigen on both resting platelets and platelets activated by thrombin (0.1 U/ml), collagen (5 microg/ml) or ADP (5 microM). Adenosine Diphosphate 219-222 coagulation factor III, tissue factor Homo sapiens 108-110 26216931-5 2015 In a subgroup of patients (n = 28) ADP-induced P-selectin expression was measured in dependence of the time point of study drug intake in RPs that were discriminated from mature platelets by thiazole-orange (TO) staining. Adenosine Diphosphate 35-38 selectin P Homo sapiens 47-57 12034376-7 2002 ADP and TRAP elicited P-selectin expression in the absence of platelet aggregation, while collagen produced no such reaction. Adenosine Diphosphate 0-3 selectin P Homo sapiens 22-32 12034376-8 2002 SC-57101A only moderately inhibited P-selectin expression induced by ADP and had no inhibitory effect on that induced by TRAP. Adenosine Diphosphate 69-72 selectin P Homo sapiens 36-46 12015420-7 2002 Purified PKC inhibited Kir6.1/SUR2B activity (in 0.5 mM ATP/ 0.5 mM ADP), and the inhibition was blocked by a specific peptide inhibitor of PKC, PKC(19-31). Adenosine Diphosphate 68-71 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 23-29 26441936-3 2015 The datA locus is instrumental in conversion of DnaA(ATP) to DnaA(ADP) (datA dependent DnaA(ATP) hydrolysis) whereas DnaA rejuvenation sequences 1 and 2 (DARS1 and DARS2) reactivate DnaA(ADP) to DnaA(ATP). Adenosine Diphosphate 66-69 aspartyl-tRNA synthetase 2 (mitochondrial) Mus musculus 164-169 12034470-5 2002 Under these conditions, mitochondria have a more native, condensed configuration.Flux-dependent concentration gradients of ADP were estimated by measuring the ADP diffusion fluxes across the porin pores of isolated rat heart mitochondria incubated together with pyruvate kinase (PK), both of which compete for ADP regenerated by mitochondrial creatine kinase (mtCK) within the intermembrane space or by yeast hexokinase (HK) extramitochondrially. Adenosine Diphosphate 123-126 hexokinase Saccharomyces cerevisiae S288C 409-419 11929769-4 2002 In contrast, we now show that NTPDase2 (CD39L1, 75 kd), a preferential nucleoside triphosphatase, activates platelet aggregation by converting adenosine triphosphate (ATP) to ADP, the specific agonist of P2Y(1) and P2Y(12) receptors. Adenosine Diphosphate 175-178 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 204-210 11929769-4 2002 In contrast, we now show that NTPDase2 (CD39L1, 75 kd), a preferential nucleoside triphosphatase, activates platelet aggregation by converting adenosine triphosphate (ATP) to ADP, the specific agonist of P2Y(1) and P2Y(12) receptors. Adenosine Diphosphate 175-178 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 215-222 11929769-9 2002 Our data suggest that specific NTPDases, in tandem with ecto-5"-nucleotidase, not only terminate P2 receptor activation and trigger adenosine receptors but may also allow preferential activation of specific subsets of P2 receptors sensitive to ADP (e.g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6)). Adenosine Diphosphate 244-247 5' nucleotidase, ecto Mus musculus 56-76 11929769-9 2002 Our data suggest that specific NTPDases, in tandem with ecto-5"-nucleotidase, not only terminate P2 receptor activation and trigger adenosine receptors but may also allow preferential activation of specific subsets of P2 receptors sensitive to ADP (e.g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6)). Adenosine Diphosphate 244-247 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 255-261 11929769-9 2002 Our data suggest that specific NTPDases, in tandem with ecto-5"-nucleotidase, not only terminate P2 receptor activation and trigger adenosine receptors but may also allow preferential activation of specific subsets of P2 receptors sensitive to ADP (e.g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6)). Adenosine Diphosphate 244-247 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 271-278 11929769-9 2002 Our data suggest that specific NTPDases, in tandem with ecto-5"-nucleotidase, not only terminate P2 receptor activation and trigger adenosine receptors but may also allow preferential activation of specific subsets of P2 receptors sensitive to ADP (e.g., P2Y(1), P2Y(3), P2Y(12)) and uridine diphosphate (P2Y(6)). Adenosine Diphosphate 244-247 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mus musculus 305-311 12022947-3 2002 Among the various PTPC components, the adenine nucleotide translocator (ANT) appears to act as a bi-functional protein which, on the one hand, contributes to a crucial step of aerobic energy metabolism, the ADP/ATP translocation, and on the other hand, can be converted into a pro-apoptotic pore under the control of onco- and anti-oncoproteins from the Bax/Bcl-2 family. Adenosine Diphosphate 207-210 solute carrier family 25 member 6 Homo sapiens 72-75 11852668-9 2002 As expected, pravastatin treatment significantly reduced LDL-C and inhibited ADP-induced platelet aggregation, TXB2 synthesis and the expression of GMP-140--all such parameters can lead to thrombus formation and subsequent cardiovascular events. Adenosine Diphosphate 77-80 selectin P Homo sapiens 148-155 26381750-9 2015 The overexpressed CD39 protein is highly functional in hydrolyzing ADP and in preventing platelet activation. Adenosine Diphosphate 67-70 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 18-22 26356530-1 2015 Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. Adenosine Diphosphate 133-136 phosphoglycerate kinase 1 Homo sapiens 0-25 11787058-5 2002 The ATP-induced stimulation of 11beta-HSD2 activity is adenine nucleotide specific in that a similar stimulation was observed with ADP and AMP but not with CTP, GTP, or UTP. Adenosine Diphosphate 131-134 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 31-42 26356530-1 2015 Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. Adenosine Diphosphate 133-136 phosphoglycerate kinase 1 Homo sapiens 27-31 27264466-8 2001 Sialic acid suppressed ADP induced platelet aggregation and P-selectin expression in a dose dependent manner. Adenosine Diphosphate 23-26 selectin P Homo sapiens 60-70 26356530-3 2015 Here, we report that PGK1 is acetylated at lysine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP. Adenosine Diphosphate 137-140 phosphoglycerate kinase 1 Homo sapiens 21-25 26356530-3 2015 Here, we report that PGK1 is acetylated at lysine 220 (K220), which inhibits PGK1 activity by disrupting the binding with its substrate, ADP. Adenosine Diphosphate 137-140 phosphoglycerate kinase 1 Homo sapiens 77-81 26294254-5 2015 Fitting filament velocities (V) vs. N to a detachment-limited model using the myosin step size d=8 nm gave an ADP release rate 8.5-fold faster and ton (myosin"s attached time) and r (duty ratio) ~10-fold lower than previously reported. Adenosine Diphosphate 110-113 myosin heavy chain 14 Homo sapiens 78-84 11816716-7 2001 We found that platelet shape change and aggregation induced by low concentrations of collagen were strongly inhibited after selective desensitization of P2X1 with its agonists or by pretreating the platelets with a low concentration of ADP (0.5 microM), that antagonizes the P2X1 channel without desensitizing the P2Y1 receptor. Adenosine Diphosphate 236-239 purinergic receptor P2X, ligand gated ion channel, 1 L homeolog Xenopus laevis 275-279 25837286-5 2015 Specifically, in the presence of 0.25 mM ADP, the Mn IC50 was 1.14 +- 0.02 mM and 1.54 +- 0.08 mM for hGDH2 and for hGDH1, respectively (p = 0.0001). Adenosine Diphosphate 41-44 glutamate dehydrogenase 1 Homo sapiens 116-121 11481328-7 2001 In INS-1 cells oscillations in insulin secretion, the ATP/ADP ratio, and [Ca(2+)](i) were also seen, but with a shorter period of about 1.5 min. Adenosine Diphosphate 58-61 insulin 1 Rattus norvegicus 3-8 25837286-7 2015 At 1 mM ADP, the Mn IC50 was 1.84 +- 0.02 mM and 2.04 +- 0.07 mM (p = 0.01) for hGDH2 and hGDH1, respectively, with 3 mM Mn inhibiting hGDH2 by 93.6% and hGDH1 by 70.9%. Adenosine Diphosphate 8-11 glutamate dehydrogenase 1 Homo sapiens 90-95 26261303-8 2015 Loss of diphthamide prevented ADP ribosylation of eEF2, rendered cells resistant to PE and DT, but does not affect sensitivity toward other protein synthesis inhibitors, such as saporin or cycloheximide. Adenosine Diphosphate 30-33 eukaryotic translation elongation factor 2 Homo sapiens 50-54 11606185-2 2001 We demonstrate that aggregation induced by threshold concentrations of convulxin undergoes synergy with ADP acting via the P2Y12 receptor whereas there is no synergy via the P2Y1 receptor or with thromboxanes. Adenosine Diphosphate 104-107 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 123-128 26137920-6 2015 Hippuric acid at a concentration of 1 mM and 2 mM significantly reduced P-selectin/CD62P expression (p = 0.03 and p < 0.001 respectively) induced by ADP. Adenosine Diphosphate 152-155 selectin P Homo sapiens 72-82 11478981-2 2001 However, now two research groups have independently identified a new platelet receptor of unexpected structure, P2Y(12), that acts with the P2Y(1) receptor to form the site of ADP activation and explains the multiple transduction mechanisms observed in response to ADP in platelets. Adenosine Diphosphate 176-179 purinergic receptor P2Y1 Homo sapiens 140-155 11478981-2 2001 However, now two research groups have independently identified a new platelet receptor of unexpected structure, P2Y(12), that acts with the P2Y(1) receptor to form the site of ADP activation and explains the multiple transduction mechanisms observed in response to ADP in platelets. Adenosine Diphosphate 265-268 purinergic receptor P2Y1 Homo sapiens 140-155 26137920-6 2015 Hippuric acid at a concentration of 1 mM and 2 mM significantly reduced P-selectin/CD62P expression (p = 0.03 and p < 0.001 respectively) induced by ADP. Adenosine Diphosphate 152-155 selectin P Homo sapiens 83-88 26045476-4 2015 After 5 min of reperfusion (n = 4/group), prominent phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) was observed, both in control and reperfused myocardium, in animals receiving GIK, and mitochondria from these hearts showed reduced ADP-stimulated respiration. Adenosine Diphosphate 253-256 AKT serine/threonine kinase 1 Sus scrofa 71-74 25999342-5 2015 MBP-U94 is also able to hydrolyze adenosine triphosphate (ATP) to ADP, providing the energy for further catalytic activities. Adenosine Diphosphate 66-69 small nucleolar RNA, C/D box 94 Homo sapiens 4-7 26008670-7 2015 CD63 and CD62p positivity was increased in normal and in diabetic patients" platelets after activation with ADP before clopidogrel. Adenosine Diphosphate 108-111 CD63 molecule Homo sapiens 0-4 26008670-7 2015 CD63 and CD62p positivity was increased in normal and in diabetic patients" platelets after activation with ADP before clopidogrel. Adenosine Diphosphate 108-111 selectin P Homo sapiens 9-14 26008670-9 2015 CD63 and CD62p positivity in resting and ADP stimulated patients" platelets was also decreased after clopidogrel treatment. Adenosine Diphosphate 41-44 CD63 molecule Homo sapiens 0-4 26008670-9 2015 CD63 and CD62p positivity in resting and ADP stimulated patients" platelets was also decreased after clopidogrel treatment. Adenosine Diphosphate 41-44 selectin P Homo sapiens 9-14 25801937-4 2015 In the current study, ligand-binding analysis confirmed by the structural information of the binding state has been demonstrated using fluorogenic ATP/ADP photoactivatable probes under allosteric regulation of multiple substrates in the enzyme glutamate dehydrogenase (GDH). Adenosine Diphosphate 151-154 glutamate dehydrogenase 1 Homo sapiens 244-267 25801937-4 2015 In the current study, ligand-binding analysis confirmed by the structural information of the binding state has been demonstrated using fluorogenic ATP/ADP photoactivatable probes under allosteric regulation of multiple substrates in the enzyme glutamate dehydrogenase (GDH). Adenosine Diphosphate 151-154 glutamate dehydrogenase 1 Homo sapiens 269-272 25650929-0 2015 Phosphate and ADP differently inhibit coordinated smooth muscle myosin groups. Adenosine Diphosphate 14-17 myosin heavy chain 14 Homo sapiens 64-70 25650929-4 2015 We perturbed individual myosin kinetics with varying, physiological concentrations of phosphate (Pi, release associated with main power stroke) and adenosine diphosphate (ADP, release associated with minor mechanical step). Adenosine Diphosphate 148-169 myosin heavy chain 14 Homo sapiens 24-30 25650929-4 2015 We perturbed individual myosin kinetics with varying, physiological concentrations of phosphate (Pi, release associated with main power stroke) and adenosine diphosphate (ADP, release associated with minor mechanical step). Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 24-30 25650929-7 2015 We introduced specific Pi and ADP effects on individual myosin kinetics into our recently developed mathematical model of actin propulsion by myosin groups. Adenosine Diphosphate 30-33 myosin heavy chain 14 Homo sapiens 56-62 25650929-9 2015 At low [Pi] and [ADP], actin arrest and sliding were reflected by two distinct chemical states of the myosin group. Adenosine Diphosphate 17-20 myosin heavy chain 14 Homo sapiens 102-108 25547115-2 2015 Here we report ADP-ribosylation as a new post-translational modification of PTEN. Adenosine Diphosphate 15-18 phosphatase and tensin homolog Homo sapiens 76-80 25372046-4 2015 During the NTPDase1-catalyzed reaction, the substrate is dephosphorylated to ADP which is further dephosphorylated yielding AMP as the final product (by NTPDase1). Adenosine Diphosphate 77-80 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 11-19 25372046-4 2015 During the NTPDase1-catalyzed reaction, the substrate is dephosphorylated to ADP which is further dephosphorylated yielding AMP as the final product (by NTPDase1). Adenosine Diphosphate 77-80 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 153-161 25372046-5 2015 NTPDase3 and -8 yield AMP and ADP, while NTPDase2 results mainly in the formation of ADP. Adenosine Diphosphate 30-33 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 0-8 25372046-5 2015 NTPDase3 and -8 yield AMP and ADP, while NTPDase2 results mainly in the formation of ADP. Adenosine Diphosphate 85-88 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 0-8 25345495-8 2015 The lack of alpha7nAChR on platelets from these mice increased the expression of active integrin alphaIIb beta3 upon stimulation by ADP (1.9-fold, P < 0.01), indicating increased activation status, while incubation of human platelets with an alpha7nAChR agonist decreased aggregation (-35%, P < 0.05). Adenosine Diphosphate 132-135 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 12-23 25140584-10 2015 Prasugrel administration to SCD patients attenuates ex vivo ADP-stimulated platelet activation as measured by the percentage of platelets positive for P-selectin and GPIIb-IIIa, thus reducing the proportion of platelets that may participate in aggregates. Adenosine Diphosphate 60-63 selectin P Homo sapiens 151-161 25455999-9 2015 The increase in P-selectin and aGPIIb/IIIa expression induced by adenosine diphosphate (ADP) was higher in patients with elevated TRV than those with normal TRV. Adenosine Diphosphate 65-86 selectin P Homo sapiens 16-26 25455999-9 2015 The increase in P-selectin and aGPIIb/IIIa expression induced by adenosine diphosphate (ADP) was higher in patients with elevated TRV than those with normal TRV. Adenosine Diphosphate 88-91 selectin P Homo sapiens 16-26 26632148-6 2015 ADP activates human platelets by stimulating both P2Y1R and P2Y12R, which act sequentially and in concert to achieve complete platelet aggregation. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 50-55 11328809-3 2001 We have determined the crystal structure of the Eg5 motor domain with ADP-Mg bound. Adenosine Diphosphate 70-73 kinesin family member 11 Homo sapiens 48-51 25277952-4 2014 Using a combination of electrophysiological techniques, Ca(2+) imaging and measurements of insulin secretion, it is demonstrated that voltage-dependent Ca(2+) influx triggers release of ATP/ADP, which activates purinergic receptors of the Gq/11-coupled P2Y1 isoform. Adenosine Diphosphate 190-193 purinergic receptor P2Y1 Homo sapiens 253-257 11472358-5 2001 ADP and collagen also induced RAFTK phosphorylation and platelet aggregation in a PI3K activity-dependent manner, similar to that of the low-dose thrombin. Adenosine Diphosphate 0-3 protein tyrosine kinase 2 beta Homo sapiens 30-35 24824502-2 2014 A recently reported crystal structure has illuminated the complex regulatory mechanisms by which AMP and ADP cause activation of AMPK, involving phosphorylation by the upstream kinase LKB1. Adenosine Diphosphate 105-108 serine/threonine kinase 11 Homo sapiens 184-188 25186167-4 2014 The action of ADP on [Ca(2+)]i was significantly blocked by MRS2211 (a selective P2Y13 receptor antagonist), but was unaffected by MRS2179 (a selective P2Y1 receptor antagonist) or MRS2395 (a selective P2Y12 receptor antagonist), which suggest that P2Y13 receptor may be responsible for ADP-evoked Ca(2+) mobilization in cultured microglia. Adenosine Diphosphate 14-17 purinergic receptor P2Y1 Homo sapiens 152-165 25329809-5 2014 METHODS AND RESULTS: ADP concentrations were chosen to induce a biphasic aggregation curve resulting from the successive activation of both its receptors P2Y(1) and P2Y(12). Adenosine Diphosphate 21-24 purinergic receptor P2Y1 Homo sapiens 154-160 25055825-8 2014 ADP, MRS 2365, beta-NAD, and adenosine 5-diphosphate-ribose, P2Y1 agonists, hyperpolarized PDGFRalpha(+) cells, and these responses were blocked by MRS 2500. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 61-65 24816772-8 2014 Moreover, our data indicates that ApoBDS-1-induced platelet activation is partially dependent of positive feedback from ADP on P2Y1 and P2Y12, and TxA2. Adenosine Diphosphate 120-123 purinergic receptor P2Y1 Homo sapiens 127-131 24907276-5 2014 Rate constants for ATP-induced dissociation and ADP release from acto-myosin for filaments and S1 heads were similar. Adenosine Diphosphate 48-51 myosin heavy chain 14 Homo sapiens 70-76 11404398-7 2001 ADP, a selective agonist for P2Y(1), produced results similar to or greater than those obtained using ATP, whereas 2"-3"-O-(4-benzoyl-benzoyl)-ATP, a selective agonist for P2X(7), was less effective than ATP. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 29-35 11373668-5 2001 The conformational change observed between the ADP-bound and the ATP-like structures of the KIF1A catalytic core is modular, extends to all kinesins and is similar to the conformational change used by myosin motors and G proteins. Adenosine Diphosphate 47-50 kinesin family member 1A Homo sapiens 92-97 11373668-6 2001 Docking of the ADP-bound and ATP-like crystallographic models of KIF1A into the corresponding cryo-electron microscopy maps suggests a rationale for the plus-end directional bias associated with the kinesin catalytic core. Adenosine Diphosphate 15-18 kinesin family member 1A Homo sapiens 65-70 11336783-4 2001 Monolayers of thioglycollate-induced mouse peritoneal macrophages with cell surface fibronectin recognized autologous erythrocytes oxidized with an iron catalyst ADP/Fe(3+). Adenosine Diphosphate 162-165 fibronectin 1 Mus musculus 84-95 11259526-7 2001 The (m)P2Y(6) receptor was highly selective for UDP (UDP >> ADP = GDP). Adenosine Diphosphate 66-69 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mus musculus 7-13 11306353-1 2001 BACKGROUND: The Hsp90s contain a conserved pocket that binds ATP/ADP and plays an important role in the regulation of chaperone function. Adenosine Diphosphate 65-68 heat shock protein 90 alpha family class A member 1 Homo sapiens 16-21 11245415-5 2001 Verteporfin phototoxicity on ANT proteoliposomes was mediated by reactive oxygen species and was prevented by recombinant Bcl-2 or the adenine nucleotides ATP and ADP. Adenosine Diphosphate 163-166 solute carrier family 25 member 6 Homo sapiens 29-32 11156884-1 2001 BACKGROUND: ADP plays a key role in hemostasis, acting through 2 platelet receptors: the P2Y(1) receptor and an unidentified P2 receptor, called P2cyc, coupled to adenylyl cyclase inhibition, which is the target of the antiplatelet drug clopidogrel. Adenosine Diphosphate 12-15 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 89-104 11151063-8 2001 We found that physiologic concentrations of estrogen strongly and significantly inhibited the aggregation of PlA1/A2 platelets (P<.005 for epinephrine and P<.05 for adenosine diphosphate, induced aggregation, respectively) in both men and women. Adenosine Diphosphate 171-192 POU class 2 homeobox 3 Homo sapiens 109-113 11591225-8 2001 The results suggest that species D1 and D2 represent the metal-ADP complexes at the catalytic site of soluble CD39 corresponding to the intermediate formed during ATP hydrolysis and the substrate for further hydrolysis, respectively. Adenosine Diphosphate 63-66 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 110-114 25717362-6 2014 To determine if ENTPD3 contributes directly to ATP and ADP hydrolysis in these tissues, we generated and characterized an Entpd3 knockout mouse. Adenosine Diphosphate 55-58 ectonucleoside triphosphate diphosphohydrolase 3 Mus musculus 16-22 11159687-12 2001 PPADS, a selective antagonist of the P2Y(1) receptor-generated InsP(3) accumulation, decreased ADP-initiated Ca2+ response with no effect on ATP and UTP. Adenosine Diphosphate 95-98 purinergic receptor P2Y1 Homo sapiens 37-52 24898734-8 2014 While the affinity of ISWI for the nucleosome substrate with short lengths of flanking DNA was not affected by the presence of nucleotides, the affinity of ISWI for the DNA substrate is weakened in the presence of nonhydrolyzable ATP analogues but not by ADP. Adenosine Diphosphate 255-258 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 22-26 11145588-5 2001 Adenoviral overexpression of UCP3 also decreased the ADP/O ratio by 18% (nonsignificant) and increased state 4 respiration by 24% (nonsignificant) in comparison to ss-gal and significantly decreased the ADP/O ratio by 32% and increased state 4 respiration by 35% in comparison to MnSOD. Adenosine Diphosphate 53-56 uncoupling protein 3 Rattus norvegicus 29-33 11145588-5 2001 Adenoviral overexpression of UCP3 also decreased the ADP/O ratio by 18% (nonsignificant) and increased state 4 respiration by 24% (nonsignificant) in comparison to ss-gal and significantly decreased the ADP/O ratio by 32% and increased state 4 respiration by 35% in comparison to MnSOD. Adenosine Diphosphate 203-206 uncoupling protein 3 Rattus norvegicus 29-33 11018047-7 2000 These data suggest that there is a second step (ADP release) in the smooth muscle myosin-actin-activated ATPase cycle that is modulated by regulatory light chain phosphorylation. Adenosine Diphosphate 48-51 myosin heavy chain 14 Homo sapiens 82-88 24898734-8 2014 While the affinity of ISWI for the nucleosome substrate with short lengths of flanking DNA was not affected by the presence of nucleotides, the affinity of ISWI for the DNA substrate is weakened in the presence of nonhydrolyzable ATP analogues but not by ADP. Adenosine Diphosphate 255-258 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Homo sapiens 156-160 24565793-5 2014 In the absence of oxygen, the cytosolic creatine phosphate can be directly used by the ANT-CK-VDAC contact sites to produce ATP from ADP in the mitochondrial matrix. Adenosine Diphosphate 133-136 solute carrier family 25 member 6 Homo sapiens 87-90 11175251-5 2000 On the one hand, ANT is a vital, specific antiporter which accounts for the exchange of ATP and ADP on IM. Adenosine Diphosphate 96-99 solute carrier family 25 member 6 Homo sapiens 17-20 11305734-9 2000 MEASURES: the platelet activation marker P-selectin was quantified on peripheral blood platelets before and after in vitro stimulation with platelet agonists (adenosine diphosphate, thrombin receptor activator peptide-6). Adenosine Diphosphate 159-180 selectin P Homo sapiens 41-51 11060043-7 2000 Conversion of the ATP state of Hsp90 to the ADP state through hydrolysis is required for efficient release of substrate polypeptide. Adenosine Diphosphate 44-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 31-36 10995435-10 2000 Both the maximal rate of ADP-stimulated oxygen consumption and the dissociation constant (K(m)) for ADP are significantly reduced in desmin-null cardiac and soleus muscle compared with controls. Adenosine Diphosphate 25-28 desmin Mus musculus 133-139 10995435-10 2000 Both the maximal rate of ADP-stimulated oxygen consumption and the dissociation constant (K(m)) for ADP are significantly reduced in desmin-null cardiac and soleus muscle compared with controls. Adenosine Diphosphate 100-103 desmin Mus musculus 133-139 10960076-2 2000 Given the low potency of ADP at P2X(1) receptors and recognized contamination of commercial samples of adenosine nucleotides, we have re-examined the activation of P2X(1) receptors by ADP following HPLC and enzymatic purification. Adenosine Diphosphate 184-187 purinergic receptor P2X 1 Homo sapiens 164-170 10960076-3 2000 Native P2X(1) receptor currents in megakaryocytes were activated by alpha, beta-meATP (10 microM) and commercial samples of ADP (10 microM), but not by purified ADP (10 - 100 microM). Adenosine Diphosphate 124-127 purinergic receptor P2X 1 Homo sapiens 7-22 10960076-6 2000 In human platelets, P2X(1) and P2Y receptor-mediated [Ca(2+)](i) responses were distinguished by their different kinetics at 13 degrees C. In 1 mM Ca(2+) saline, alpha,beta-meATP (10 microM) and commercial ADP (40 microM) activated a rapid [Ca(2+)](i) increase (lag time < or =0.5 s) through the activation of P2X(1) receptors. Adenosine Diphosphate 206-209 purinergic receptor P2X 1 Homo sapiens 20-43 10960076-6 2000 In human platelets, P2X(1) and P2Y receptor-mediated [Ca(2+)](i) responses were distinguished by their different kinetics at 13 degrees C. In 1 mM Ca(2+) saline, alpha,beta-meATP (10 microM) and commercial ADP (40 microM) activated a rapid [Ca(2+)](i) increase (lag time < or =0.5 s) through the activation of P2X(1) receptors. Adenosine Diphosphate 206-209 purinergic receptor P2X 1 Homo sapiens 20-26 10960076-7 2000 Hexokinase treatment of ADP shifted the lag time by approximately 2 s, indicating loss of the P2X(1) receptor-mediated response. Adenosine Diphosphate 24-27 purinergic receptor P2X 1 Homo sapiens 94-109 10960076-9 2000 ATP stimulates P2X(1) receptors, whereas ADP is a selective agonist at metabotropic (P2Y(1) and P2T(AC)) receptors. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 85-91 11054084-3 2000 Sustained ADP-induced aggregation requires co-activation of P2Y(1) and P(2T) receptors. Adenosine Diphosphate 10-13 purinergic receptor P2Y1 Homo sapiens 60-66 11054084-9 2000 P(2T) receptor activation amplified ADP-induced aggregation initiated by the P2Y(1) receptor, as well as amplifying aggregation, secretion and procoagulant responses induced by other agonists, including U46619, thrombin receptor-activating peptide (TRAP) and collagen, independent of thromboxane A(2) synthesis, which played a more peripheral role. Adenosine Diphosphate 36-39 purinergic receptor P2Y1 Homo sapiens 77-92 11019976-0 2000 Desensitization of the platelet aggregation response to ADP: differential down-regulation of the P2Y1 and P2cyc receptors. Adenosine Diphosphate 56-59 purinergic receptor P2Y1 Homo sapiens 97-101 11019976-2 2000 A normal platelet response to ADP requires coactivation of the P2Y(1) receptor responsible for shape change and the P2cyc receptor, responsible for completion and amplification of the response. Adenosine Diphosphate 30-33 purinergic receptor P2Y1 Homo sapiens 63-78 10827085-3 2000 These studies indicate that for this myosin:ADP, both the catalytic site and the actin-binding site can each assume one of two conformations. Adenosine Diphosphate 44-47 myosin heavy chain 14 Homo sapiens 37-43 10827085-5 2000 Following an initial, weakly bound state, binding of myosin:ADP to actin shifts the equilibrium toward a mixture of two states that each bind actin strongly but differ in the conformation of their catalytic sites. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 53-59 10749890-1 2000 Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose 6-phosphate and ADP. Adenosine Diphosphate 156-159 hexokinase Saccharomyces cerevisiae S288C 0-10 11798806-4 2000 Platelet can be obviously activated by 0.1 micromol/L ADP, and 10.0 micromol/L ADP leaded to the peak expression of FIB-R and CD62P on the activated platelet membrane surface, FIB-R and CD62P positive percent of 87.8% and 81.34% respectively. Adenosine Diphosphate 79-82 selectin P Homo sapiens 126-131 11798806-4 2000 Platelet can be obviously activated by 0.1 micromol/L ADP, and 10.0 micromol/L ADP leaded to the peak expression of FIB-R and CD62P on the activated platelet membrane surface, FIB-R and CD62P positive percent of 87.8% and 81.34% respectively. Adenosine Diphosphate 79-82 selectin P Homo sapiens 186-191 10751402-6 2000 Whereas ADP-stimulated platelets adhered to the amino-terminal but not the carboxyl-terminal osteopontin fragment and to the osteopontin peptide RGDSVVYGLR, phorbol ester-stimulated B cells did not adhere to this peptide, although they did so in the presence of 1 mm Mn(2+). Adenosine Diphosphate 8-11 secreted phosphoprotein 1 Homo sapiens 125-136 24838375-3 2014 CD39, the dominant vascular nucleotidase, hydrolyzes ATP and ADP to provide the substrate for generation of the anti-inflammatory and antithrombotic mediator adenosine. Adenosine Diphosphate 61-64 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 24914973-3 2014 Here, it is demonstrated that the purified helicase domain of human Prp28 (hPrp28DeltaN) binds ADP, whereas binding of ATP and ATPase activity could not be detected. Adenosine Diphosphate 95-98 DEAD-box helicase 23 Homo sapiens 68-73 24823650-6 2014 In addition, the affinity of Fap7 for Rps14 is higher with bound ADP, whereas ATP hydrolysis dissociates the complex. Adenosine Diphosphate 65-68 ribosomal protein S14 Homo sapiens 38-43 24732354-0 2014 Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation. Adenosine Diphosphate 24-27 kinesin family member 11 Homo sapiens 118-121 24732354-5 2014 We analyze their interactions with ADP-bound Eg5 crystal structure, and find that dimethylenastron binds Eg5 motor domain with higher affinity. Adenosine Diphosphate 35-38 kinesin family member 11 Homo sapiens 45-48 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 13-34 ribosomal protein S6 kinase B1 Homo sapiens 127-133 24762409-6 2014 The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi) and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Adenosine Diphosphate 113-116 myosin heavy chain 14 Homo sapiens 72-78 24762409-6 2014 The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi) and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 72-78 24762409-6 2014 The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi) and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 176-182 24762409-6 2014 The results obtained by this combined multi-scale calculation show that myosin with inorganic phosphate (Pi) and ADP weakly binds to actin and that after releasing Pi and ADP, myosin moves along the actin filament toward the strong-binding site by exhibiting the biased Brownian motion, a behavior consistent with the observed single-molecular behavior of myosin. Adenosine Diphosphate 171-174 myosin heavy chain 14 Homo sapiens 176-182 24361322-6 2014 RESULTS: After RBC transfusion, platelet reactivity was increased when measured using adenosine diphosphate-induced light transmission aggregometry (11.6% relative increase in maximal platelet aggregation, p = 0.004; 10.8% increase in residual platelet aggregation, p = 0.005) and vasodilator-stimulated phosphoprotein platelet reactivity index (20.7% relative increase, p = 0.002), and there was a nonsignificant trend toward an increase in P-selectin expression. Adenosine Diphosphate 86-107 selectin P Homo sapiens 442-452 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 106-109 selectin P Homo sapiens 31-41 10841224-2 2000 BACKGROUND: The ANT, the only mitochondrial carrier for ADP and ATP, plays a significant role in the energy metabolism and is involved in the apoptosis process. Adenosine Diphosphate 56-59 solute carrier family 25 member 6 Homo sapiens 16-19 10801326-6 2000 The addition of eIF4B resulted in a change in binding affinity for ATP, increasing it almost 10-fold while the ADP binding affinity was approximately the same. Adenosine Diphosphate 111-114 eukaryotic translation initiation factor 4B1 Triticum aestivum 16-21 10735780-4 2000 Unfractionated heparin increased adenosine diphosphate-induced expression of P-selectin and GP IIb-IIIa in a dose-dependent manner. Adenosine Diphosphate 33-54 selectin P Homo sapiens 77-87 10810178-2 2000 It was found that PGE1-PPAF inhibits the PAF-, ADP-, and thrombin-induced platelet aggregation in platelet-rich plasma. Adenosine Diphosphate 47-50 PCNA clamp associated factor Homo sapiens 24-27 10810178-3 2000 1-O-alk-1;-enyl-2-acetyl-sn-glycero-3-phosphoethanolamine inhibited PAF-induced aggregation up to 50% but had no influence on platelet aggregation induced by ADP or thrombin. Adenosine Diphosphate 158-161 PCNA clamp associated factor Homo sapiens 68-71 10810178-4 2000 The ethanolamine plasmalogen analog of PAF 1-O-alk-1;-enyl-2-acetyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolami ne, having a palmitoyl residue instead of PGE1, did not inhibit platelet aggregation induced by PAF, ADP, or thrombin. Adenosine Diphosphate 214-217 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 39-44 10810178-4 2000 The ethanolamine plasmalogen analog of PAF 1-O-alk-1;-enyl-2-acetyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolami ne, having a palmitoyl residue instead of PGE1, did not inhibit platelet aggregation induced by PAF, ADP, or thrombin. Adenosine Diphosphate 214-217 PCNA clamp associated factor Homo sapiens 39-42 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 105-108 purinergic receptor P2Y1 Homo sapiens 23-36 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 105-108 purinergic receptor P2Y1 Homo sapiens 196-209 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 225-228 purinergic receptor P2Y1 Homo sapiens 23-36 10759852-8 2000 On the other hand, the P2Y1 receptor selective antagonist, adenosine-2"-phosphate-5"-phosphate inhibited ADP-induced p38 kinase activation in a concentration-dependent manner, indicating that the P2Y1 receptor alone mediates ADP-induced generation of the p38 kinase-activating factor. Adenosine Diphosphate 225-228 purinergic receptor P2Y1 Homo sapiens 196-209 10759852-9 2000 These results demonstrate that ADP causes the generation of a factor in human platelets, which can activate p38 kinase, and that this response is mediated by the P2Y1 receptor. Adenosine Diphosphate 31-34 purinergic receptor P2Y1 Homo sapiens 162-175 10722048-0 2000 Anomalous binding of MgADP to myosin of skeletal muscle. Adenosine Diphosphate 21-26 myosin heavy chain 14 Homo sapiens 30-36 10656404-1 2000 Two pools of hexokinase activities differing in sensitivity to ADP inhibition were characterised in maize roots. Adenosine Diphosphate 63-66 hexokinase 2 Zea mays 13-23 10606627-2 1999 ADP-induced platelet activation involves the purinergic P2Y(1) receptor, which is responsible for shape change through intracellular calcium mobilization. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 56-71 10606627-6 1999 However, platelets from P2Y(1)-deficient mice are unable to aggregate in response to usual concentrations of ADP and display impaired aggregation to other agonists, while high concentrations of ADP induce platelet aggregation without shape change. Adenosine Diphosphate 109-112 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 24-30 10606627-8 1999 P2Y(1)-null mice have no spontaneous bleeding tendency but are resistant to thromboembolism induced by intravenous injection of ADP or collagen and adrenaline. Adenosine Diphosphate 128-131 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 0-6 10915472-10 1999 The results demonstrated that PAF-stimulated platelet aggregation was significantly inhibited with SNP (10(-5) M) to 82% (p < .05) of control and epinephrine and ADP mediated aggregation were not significantly affected. Adenosine Diphosphate 165-168 PCNA clamp associated factor Homo sapiens 30-33 10551820-4 1999 For both IKKalpha and IKKbeta, the product ADP was a competitive inhibitor versus ATP and a non-competitive inhibitor versus IkappaBalpha. Adenosine Diphosphate 43-46 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 22-29 10551820-12 1999 The strong inhibition of IKKbeta by staurosporine (K(i) = 172 nM) and ADP (K(i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases. Adenosine Diphosphate 70-73 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 25-32 10551820-12 1999 The strong inhibition of IKKbeta by staurosporine (K(i) = 172 nM) and ADP (K(i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases. Adenosine Diphosphate 70-73 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 180-187 10542202-0 1999 Modification of the ADP-ribosyltransferase and NAD glycohydrolase activities of a mammalian transferase (ADP-ribosyltransferase 5) by auto-ADP-ribosylation. Adenosine Diphosphate 20-23 ADP-ribosyltransferase 5 Homo sapiens 105-129 10542202-7 1999 Based on the change in mobility of auto-ADP-ribosylated ART5 by SDS-polyacrylamide gel electrophoresis, the modification appeared to be stoichiometric and resulted in the addition of at least two ADP-ribose moieties. Adenosine Diphosphate 40-43 ADP-ribosyltransferase 5 Homo sapiens 56-60 10542202-7 1999 Based on the change in mobility of auto-ADP-ribosylated ART5 by SDS-polyacrylamide gel electrophoresis, the modification appeared to be stoichiometric and resulted in the addition of at least two ADP-ribose moieties. Adenosine Diphosphate 196-199 ADP-ribosyltransferase 5 Homo sapiens 56-60 10605819-4 1999 The coupling between respiration and ADP phosphorylation is only partial in brown adipose tissue (BAT) mitochondria, where the uncoupling protein UCP1 causes a reentry of protons into the matrix and abolishes the electrochemical proton gradient. Adenosine Diphosphate 37-40 uncoupling protein 1 Homo sapiens 146-150 10730576-0 1999 Kinetic studies on the effects of ADP and ionic strength on the interaction between myosin subfragment-1 and actin: implications for load-sensitivity and regulation of the crossbridge cycle. Adenosine Diphosphate 34-37 myosin heavy chain 14 Homo sapiens 84-90 10595651-2 1999 Therefore, hydrolysis of extracellular ATP and ADP by the ATP diphosphohydrolase (ATPDase) could regulate these processes. Adenosine Diphosphate 47-50 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 58-80 10595651-2 1999 Therefore, hydrolysis of extracellular ATP and ADP by the ATP diphosphohydrolase (ATPDase) could regulate these processes. Adenosine Diphosphate 47-50 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 82-89 10521254-2 1999 Suppression of constitutive CD39 expression may result in elevated concentrations of ATP and ADP at the vascular interface that could predispose to thrombosis and inflammation. Adenosine Diphosphate 93-96 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 28-32 10506165-4 1999 ADP-induced platelet aggregation requires concomitant signaling from two P2 receptor subtypes, P2Y1 and P2T(AC), coupled to G(q) and G(i), respectively. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 95-99 10486009-5 1999 The two domain IV regions (one of which comprises the ADP-ribosylatable site of EF-2) are almost certainly due to the artifactual alignment of insertion segments that are unique to Bacteria and to Archaea-Eucarya. Adenosine Diphosphate 54-57 eukaryotic translation elongation factor 2 Homo sapiens 80-84 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 198-201 selectin P Homo sapiens 31-41 10502826-4 1999 We show here that the purinoceptor P2Y1 is required for platelet shape change in response to ADP and is also a principal receptor mediating ADP-induced platelet aggregation. Adenosine Diphosphate 93-96 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 35-39 10502826-4 1999 We show here that the purinoceptor P2Y1 is required for platelet shape change in response to ADP and is also a principal receptor mediating ADP-induced platelet aggregation. Adenosine Diphosphate 140-143 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 35-39 10502826-7 1999 In vivo, the lack of P2Y1 expression increased bleeding time and protected from collagen- and ADP-induced thromboembolism. Adenosine Diphosphate 94-97 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 21-25 10502826-8 1999 These findings support the hypothesis that the ATP receptor P2Y1 is a principal receptor mediating both physiologic and pathological ADP-induced processes in platelets. Adenosine Diphosphate 133-136 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 60-64 10548063-0 1999 Cooperative effects of potassium, magnesium, and magnesium-ADP on the release of Escherichia coli dihydrofolate reductase from the chaperonin GroEL. Adenosine Diphosphate 49-62 chaperonin GroEL Escherichia coli 131-147 24401225-7 2014 Likewise, the expression of P-selectin and GPIIb/IIIa following stimulation with ADP and AA, and MPA formation in response to ADP were significantly higher in PAD patients than in CAD patients. Adenosine Diphosphate 81-84 selectin P Homo sapiens 28-38 24096094-6 2014 This negative role for Mcl-1 on the bone-resorptive activities of osteoclasts may be caused by the increase in adenosine triphosphate/adenosine diphosphate ratio. Adenosine Diphosphate 134-155 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 23-28 10527412-0 1999 Role of secreted adenosine diphosphate in the synergistic effects of cathepsin G on human platelets. Adenosine Diphosphate 17-38 cathepsin G Homo sapiens 69-80 10446209-5 1999 Agonist (ADP, thrombin, or U46619)-stimulated but not resting platelets adhered to both Cyr61 and Fisp12/mCTGF, and this process was completely inhibited by prostaglandin I(2), which prevents platelet activation. Adenosine Diphosphate 9-12 cellular communication network factor 1 Homo sapiens 88-93 25562168-10 2014 Accelerated anaerobic glycolysis and reduced ATP/ADP ratio detected in DMT1-mutant erythrocytes indicate enhanced demand for ATP. Adenosine Diphosphate 49-52 solute carrier family 11 member 2 Homo sapiens 71-75 10498802-1 1999 It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, respectively. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 38-44 10498802-1 1999 It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, respectively. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 174-180 10498802-1 1999 It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, respectively. Adenosine Diphosphate 221-224 myosin heavy chain 14 Homo sapiens 38-44 25369343-5 2014 We present the first 3D structure of the ADP-bound human Lon S885A mutant obtained by electron microscopy as a result of preliminary negative staining studies. Adenosine Diphosphate 41-44 lon peptidase 1, mitochondrial Homo sapiens 57-60 10498802-1 1999 It is known that ternary complexes of myosin subfragment 1 (S1) with ADP and the Pi analogs beryllium fluoride (BeFx) and aluminum fluoride (AlF4-) are stable analogs of the myosin ATPase intermediates M* x ATP and M** x ADP x Pi, respectively. Adenosine Diphosphate 221-224 myosin heavy chain 14 Homo sapiens 174-180 24091796-4 2014 The major effect of phosphorylation and ADP-ribosylation is the disassembly of desmin filaments, while ubiquitylation of desmin leads to its degradation. Adenosine Diphosphate 40-43 desmin Homo sapiens 79-85 10462360-4 1999 Ranitidine and cimetidine reduced markedly, in same concentration, P-selectin levels after induction of aggregation by 5 microm ADP, 1 microg/mL collagen and 3 microM arachidonic acid. Adenosine Diphosphate 128-131 selectin P Homo sapiens 67-77 10411652-6 1999 In contrast, in the nonprenylated RhoA/Rho-GDI complex, the levels of ADP-ribosylation and GDP/GTP exchange are of the same order as those measured on free RhoA and are not modified by phosphoinositides. Adenosine Diphosphate 70-73 Rho GDP dissociation inhibitor alpha Homo sapiens 39-46 10194333-5 1999 This suggests that when DnaK encounters a DnaJ-bound polypeptide or protein complex, a significant fraction of such events result in ATP hydrolysis by DnaK and concomitant capture of the polypeptide substrate in a tight complex with DnaK.ADP. Adenosine Diphosphate 238-241 DnaJ Escherichia coli 42-46 24091796-5 2014 The regulation of the desmin filament network by phosphorylation and ADP-ribosylation was found to be implicated in several major biological processes such as myogenesis, myoblast fusion, muscle contraction, muscle atrophy, cell division and possibly desmin interactions with its binding partners. Adenosine Diphosphate 69-72 desmin Homo sapiens 22-28 10068454-5 1999 First, it was found that ADP-ribosylated desmin does not coassemble with unmodified desmin and has no effect on assembly of unmodified desmin. Adenosine Diphosphate 25-28 desmin Homo sapiens 41-47 24091796-5 2014 The regulation of the desmin filament network by phosphorylation and ADP-ribosylation was found to be implicated in several major biological processes such as myogenesis, myoblast fusion, muscle contraction, muscle atrophy, cell division and possibly desmin interactions with its binding partners. Adenosine Diphosphate 69-72 desmin Homo sapiens 251-257 10068454-7 1999 Finally, the structural components of the attached ADP-ribose moiety responsible for altering the assembly of desmin into filaments were investigated by a stepwise cleavage of ADP-ribose with snake venom phosphodiesterase and alkaline phophatase, followed by analysis of assembly. Adenosine Diphosphate 51-54 desmin Homo sapiens 110-116 24270421-6 2013 Further, alphaIIbbeta3 activation and activation of the small GTPase Rap1 were impaired by vWF/p.V1316M following exposure to platelet agonists (thrombin, ADP, or convulxin). Adenosine Diphosphate 155-158 RAP1A, member of RAS oncogene family Homo sapiens 69-73 10078199-4 1999 This change in membrane potential results from the failure of the adenine nucleotide translocator (ANT)/voltage-dependent anion channel (VDAC) complex to maintain ATP/ADP exchange. Adenosine Diphosphate 167-170 solute carrier family 25 member 6 Homo sapiens 66-97 10078199-4 1999 This change in membrane potential results from the failure of the adenine nucleotide translocator (ANT)/voltage-dependent anion channel (VDAC) complex to maintain ATP/ADP exchange. Adenosine Diphosphate 167-170 solute carrier family 25 member 6 Homo sapiens 99-102 10078208-3 1999 We demonstrate that mismmatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts hMSH2-hMSH6 into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. Adenosine Diphosphate 45-48 mutS homolog 6 Homo sapiens 141-146 23290998-2 2013 PARPs use NAD(+) as substrate and upon cleaving off nicotinamide they transfer the ADP-ribosyl moiety covalently to suitable acceptor proteins and elongate the chain by adding further ADP-ribose units to create a branched polymer, termed poly(ADP-ribose) (PAR), which is rapidly degraded by poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosylhydrolase 3 (ARH3). Adenosine Diphosphate 83-86 ADP-ribosylserine hydrolase Homo sapiens 334-356 23290998-2 2013 PARPs use NAD(+) as substrate and upon cleaving off nicotinamide they transfer the ADP-ribosyl moiety covalently to suitable acceptor proteins and elongate the chain by adding further ADP-ribose units to create a branched polymer, termed poly(ADP-ribose) (PAR), which is rapidly degraded by poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosylhydrolase 3 (ARH3). Adenosine Diphosphate 83-86 ADP-ribosylserine hydrolase Homo sapiens 358-362 10064008-7 1999 These results suggest that secreted dense granule ADP and ATP contribute to the maintenance of elevated [Ca2+]i levels, but not to the initial [Ca2+]i increases, in stimulated human platelets, most likely via a nucleotide-specific component of Ca2+ influx which may be mediated by interactions with both P2X1 and P2Y1 purinoceptors. Adenosine Diphosphate 50-53 purinergic receptor P2X 1 Homo sapiens 304-308 10064008-7 1999 These results suggest that secreted dense granule ADP and ATP contribute to the maintenance of elevated [Ca2+]i levels, but not to the initial [Ca2+]i increases, in stimulated human platelets, most likely via a nucleotide-specific component of Ca2+ influx which may be mediated by interactions with both P2X1 and P2Y1 purinoceptors. Adenosine Diphosphate 50-53 purinergic receptor P2Y1 Homo sapiens 313-317 16801119-0 1999 The P2Y1 receptor is essential for ADP-induced shape change and aggregation in mouse platelets. Adenosine Diphosphate 35-38 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 4-17 16801119-2 1999 We have recently demonstrated that the P2Y1 receptor plays an important role in ADP-induced shape change and aggregation in human platelets. Adenosine Diphosphate 80-83 purinergic receptor P2Y1 Homo sapiens 39-52 16801119-4 1999 However, before proceeding to the P2Y1 gene-knockout mice generation, it is important to demonstrate that the P2Y1 receptor plays an essential role in ADP-induced shape change and aggregation in mouse platelets. Adenosine Diphosphate 151-154 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 110-123 23290998-2 2013 PARPs use NAD(+) as substrate and upon cleaving off nicotinamide they transfer the ADP-ribosyl moiety covalently to suitable acceptor proteins and elongate the chain by adding further ADP-ribose units to create a branched polymer, termed poly(ADP-ribose) (PAR), which is rapidly degraded by poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosylhydrolase 3 (ARH3). Adenosine Diphosphate 184-187 ADP-ribosylserine hydrolase Homo sapiens 334-356 16801119-8 1999 On the other hand, adenosine-2"-phosphate-5"-phosphate (A2P5P), a P2Y1 receptor-selective antagonist, caused a dose-dependent inhibition of ADP-induced aggregation and shape change, as well as inhibiting the mobilization of calcium from intracellular stores. Adenosine Diphosphate 140-143 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 66-79 23290998-2 2013 PARPs use NAD(+) as substrate and upon cleaving off nicotinamide they transfer the ADP-ribosyl moiety covalently to suitable acceptor proteins and elongate the chain by adding further ADP-ribose units to create a branched polymer, termed poly(ADP-ribose) (PAR), which is rapidly degraded by poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosylhydrolase 3 (ARH3). Adenosine Diphosphate 184-187 ADP-ribosylserine hydrolase Homo sapiens 358-362 9887960-5 1998 The binding of ADP to myosin is strong in the smooth muscle contractile system, a property that might be associated with the generally slow cross-bridge turn over. Adenosine Diphosphate 15-18 myosin heavy chain 14 Homo sapiens 22-28 24071464-1 2013 BACKGROUND: Platelets express two ADP receptors namely P2Y1 and P2Y12 that regulate ADP and other agonists-induced platelet aggregation. Adenosine Diphosphate 34-37 purinergic receptor P2Y1 Homo sapiens 55-59 9887963-1 1998 This review focuses on experiments in which the single turnover of myosin-bound ADP is used to characterize the regulation of the cross-bridge cycle by myosin light chain phosphorylation in mammalian smooth muscle. Adenosine Diphosphate 80-83 myosin heavy chain 14 Homo sapiens 67-73 9887963-1 1998 This review focuses on experiments in which the single turnover of myosin-bound ADP is used to characterize the regulation of the cross-bridge cycle by myosin light chain phosphorylation in mammalian smooth muscle. Adenosine Diphosphate 80-83 myosin heavy chain 14 Homo sapiens 152-158 24071464-12 2013 Similarly, low ATP concentrations potentiated epinephrine-induced platelet aggregation that was abolished by P2Y1 antagonist MRS2500 suggesting P2Y1 receptor activation due to contaminating ADP. Adenosine Diphosphate 190-193 purinergic receptor P2Y1 Homo sapiens 109-113 9887963-7 1998 The expected effect of such a rapid turnover of light chain phosphorylation on the turnover of myosin-bound ADP is not observed. Adenosine Diphosphate 108-111 myosin heavy chain 14 Homo sapiens 95-101 24071464-12 2013 Similarly, low ATP concentrations potentiated epinephrine-induced platelet aggregation that was abolished by P2Y1 antagonist MRS2500 suggesting P2Y1 receptor activation due to contaminating ADP. Adenosine Diphosphate 190-193 purinergic receptor P2Y1 Homo sapiens 144-157 9858246-1 1998 Recently we showed that the P2Y1 receptor coupled to calcium mobilization is necessary to initiate ADP-induced human platelet aggregation. Adenosine Diphosphate 99-102 purinergic receptor P2Y1 Homo sapiens 28-41 23369757-3 2013 RCAN1 proteins have been shown to regulate various other proteins and cellular functions, including calcineurin, glycogen synthase kinase-3beta (GSK-3beta), the mitochondrial adenine nucleotide transporter (ANT), stress adaptation, ADP/ATP exchange in mitochondria, and the mitochondrial permeability transition pore (mtPTP). Adenosine Diphosphate 232-235 regulator of calcineurin 1 Homo sapiens 0-5 9855642-6 1998 Similar full agonist activities of ATP, 2-methylthio-ATP, and ADP were observed in human embryonic kidney 293 cells, which natively express the P2Y1 receptor. Adenosine Diphosphate 62-65 purinergic receptor P2Y1 Homo sapiens 144-157 23369757-11 2013 Such neurodegeneration may be precipitated by (RCAN1-1L-mediated) prolonged calcineurin inhibition and GSK-3beta induction/activation, both of which promote tau hyperphosphorylation, and/or by (RCAN1-1L-mediated) effects on the mitochondrial ANT, diminished ATP/ADP ratio, opening of the mtPTP, and mitochondrial autophagy. Adenosine Diphosphate 262-265 regulator of calcineurin 1 Homo sapiens 47-52 9832574-3 1998 Platelet activation was measured at time of entry and 30 minutes later by surface expression of P-selectin in response to increasing concentrations of the agonist ADP (0, 2, 5, 10, and 20 microM) using fluorescence-activated flow cytometry. Adenosine Diphosphate 163-166 selectin P Homo sapiens 96-106 23986721-3 2013 A bottom-up ODE approach allowed prediction of platelet calcium and phosphoinositides following P2Y1 activation with ADP, either for a population average or single cell stochastic behavior. Adenosine Diphosphate 117-120 purinergic receptor P2Y1 Homo sapiens 96-100 9817749-7 1998 Based on a new crystal structure of the NH2-terminal domain of human Hsp90 with bound ADP-Mg and on the structural homology of this domain with the ATPase domain of Escherichia coli DNA gyrase, the residues of Hsp90 critical in ATP binding (D93) and ATP hydrolysis (E47) were identified. Adenosine Diphosphate 86-89 heat shock protein 90 alpha family class A member 1 Homo sapiens 69-74 9817749-7 1998 Based on a new crystal structure of the NH2-terminal domain of human Hsp90 with bound ADP-Mg and on the structural homology of this domain with the ATPase domain of Escherichia coli DNA gyrase, the residues of Hsp90 critical in ATP binding (D93) and ATP hydrolysis (E47) were identified. Adenosine Diphosphate 86-89 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 210-215 24032868-1 2013 KIF1A is a single-headed molecular motor that moves processively and unidirectionally along a microtubule by using the chemical energy released by hydrolyzing adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and inorganic phosphate (P(i)). Adenosine Diphosphate 193-214 kinesin family member 1A Homo sapiens 0-5 9858776-0 1998 Protein cross talking through osmotic work: the free energy of formation of the MgADP-myosin complexes at the muscle protein osmotic pressure. Adenosine Diphosphate 80-85 myosin heavy chain 14 Homo sapiens 86-92 9858776-2 1998 It is found that, at 18 kP, the putative protein osmotic pressure in skeletal muscle, the increase of MgADP from 0.05 to 2 mmolal, increases the free energy of myosin-ADP and of myosin-(ADP)2 by 0. Adenosine Diphosphate 102-107 myosin heavy chain 14 Homo sapiens 160-166 9858776-2 1998 It is found that, at 18 kP, the putative protein osmotic pressure in skeletal muscle, the increase of MgADP from 0.05 to 2 mmolal, increases the free energy of myosin-ADP and of myosin-(ADP)2 by 0. Adenosine Diphosphate 102-107 myosin heavy chain 14 Homo sapiens 178-184 9858776-4 1998 It is pointed out that the local changes of water chemical potential, induced by the binding of MgADP to myosin, can be sensed by other structures of the contractile machinery, which per se may even be insensitive to MgADP. Adenosine Diphosphate 96-101 myosin heavy chain 14 Homo sapiens 105-111 9786863-4 1998 Finally, kinetic studies on the interactions of myosin-ADP constructs with actin are also consistent with a model in which interactions occur between the two heads, which are lost with regulatory light chain phosphorylation. Adenosine Diphosphate 55-58 myosin heavy chain 14 Homo sapiens 48-54 9753703-8 1998 P-selectin, a marker of platelet degranulation was significantly elevated after ADP-induced stimulation at all timepoints compared to controls. Adenosine Diphosphate 80-83 selectin P Homo sapiens 0-10 24032868-1 2013 KIF1A is a single-headed molecular motor that moves processively and unidirectionally along a microtubule by using the chemical energy released by hydrolyzing adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and inorganic phosphate (P(i)). Adenosine Diphosphate 216-219 kinesin family member 1A Homo sapiens 0-5 9831901-2 1998 ADP is a potent agonist of rat and human P2Y1 purinoceptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 41-45 23849096-0 2013 Effect of P2Y1 and P2Y12 genetic polymorphisms on the ADP-induced platelet aggregation in a Korean population. Adenosine Diphosphate 54-57 purinergic receptor P2Y1 Homo sapiens 10-14 23849096-1 2013 BACKGROUND: P2Y1 and P2Y12 receptors are expressed in platelet membranes and are involved in ADP-induced platelet aggregation. Adenosine Diphosphate 93-96 purinergic receptor P2Y1 Homo sapiens 12-16 23849096-2 2013 Genetic polymorphisms of P2Y1 and P2Y12 play a major role in the variation of ADP-induced platelet aggregation and in response in antiplatelet therapy. Adenosine Diphosphate 78-81 purinergic receptor P2Y1 Homo sapiens 25-29 9748331-2 1998 Human recombinant CD38 catalyzes the formation of both cyclic ADP-ribose and ADP-ribose products from NAD+ and hydrolyzes cyclic ADP-ribose to ADP-ribose. Adenosine Diphosphate 62-65 CD38 molecule Homo sapiens 18-22 22197119-6 2013 RESULTS: MPAs and expression of platelet receptors CD41 and PAC-1 were significantly lower in patients with than patients without PIA, both with and without ADP stimulation. Adenosine Diphosphate 157-160 ADCYAP receptor type I Homo sapiens 60-65 9748490-3 1998 PRS I is more sensitive to inhibition by ADP and GDP than is PRS II. Adenosine Diphosphate 41-44 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 0-5 23070807-4 2013 The results demonstrated an increased E-NTPDase activity (both ATP and ADP as substrates) and a decreased E-ADA activity in RA patients. Adenosine Diphosphate 71-74 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 38-47 9714750-5 1998 Binding of ADP or ATP to a matrix site of the ANT antagonises this effect of Ca2+; modification of other ANT thiol groups inhibits ADP binding and sensitises the MPT to [Ca2+]. Adenosine Diphosphate 11-14 solute carrier family 25 member 6 Homo sapiens 46-49 9714750-5 1998 Binding of ADP or ATP to a matrix site of the ANT antagonises this effect of Ca2+; modification of other ANT thiol groups inhibits ADP binding and sensitises the MPT to [Ca2+]. Adenosine Diphosphate 131-134 solute carrier family 25 member 6 Homo sapiens 46-49 9714750-5 1998 Binding of ADP or ATP to a matrix site of the ANT antagonises this effect of Ca2+; modification of other ANT thiol groups inhibits ADP binding and sensitises the MPT to [Ca2+]. Adenosine Diphosphate 131-134 solute carrier family 25 member 6 Homo sapiens 105-108 9877231-6 1998 Micromolar concentrations of ATP, ADP, GTP or GDP each inhibited the carboxyl methylation of PP2Ac and, to a lesser degree, the catalytic activity of PP2A. Adenosine Diphosphate 34-37 protein phosphatase 2 catalytic subunit alpha Homo sapiens 93-98 9877231-6 1998 Micromolar concentrations of ATP, ADP, GTP or GDP each inhibited the carboxyl methylation of PP2Ac and, to a lesser degree, the catalytic activity of PP2A. Adenosine Diphosphate 34-37 protein phosphatase 2 phosphatase activator Homo sapiens 93-97 9639511-0 1998 The P2Y1 receptor is necessary for adenosine 5"-diphosphate-induced platelet aggregation. Adenosine Diphosphate 35-59 purinergic receptor P2Y1 Homo sapiens 4-17 9639511-1 1998 The human P2Y1 receptor heterologously expressed in Jurkat cells behaves as a specific adenosine 5"-diphosphate (ADP) receptor at which purified adenosine triphosphate (ATP) is an ineffective agonist, but competitively antagonizes the action of ADP. Adenosine Diphosphate 113-116 purinergic receptor P2Y1 Homo sapiens 10-23 9639511-3 1998 In the present work, we examined the effects on ADP-induced platelet responses of two selective and competitive P2Y1 antagonists, adenosine-2"-phosphate-5"-phosphate (A2P5P) and adenosine-3"-phosphate-5"-phosphate (A3P5P). Adenosine Diphosphate 48-51 purinergic receptor P2Y1 Homo sapiens 112-116 9639511-5 1998 A2P5P and A3P5P inhibited ADP-induced platelet shape change and aggregation (pA2 = 5) and competitively antagonized calcium movements in response to ADP in fura-2-loaded platelets, B10 cells, and P2Y1-Jurkat cells. Adenosine Diphosphate 149-152 purinergic receptor P2Y1 Homo sapiens 196-200 9639511-7 1998 These identical signaling responses and pharmacologic properties suggest that platelets and BCEC share a common P2Y1 receptor involved in ADP-induced aggregation and vasodilation, respectively. Adenosine Diphosphate 138-141 purinergic receptor P2Y1 Homo sapiens 112-125 9639511-8 1998 This P2Y1 receptor coupled to the mobilization of intracellular calcium stores was found to be necessary to trigger ADP-induced platelet aggregation. Adenosine Diphosphate 116-119 purinergic receptor P2Y1 Homo sapiens 5-18 9767427-3 1998 Both the ADP-ribosylation activity of LTA and GM1 binding of LTB have been proposed to be involved in immune stimulation. Adenosine Diphosphate 9-12 lymphotoxin B Mus musculus 61-64 9676430-1 1998 The human lymphoid cell activation antigen CD39 is a known E-type apyrase that hydrolyzes extracellular ATP and ADP, a function important in homotypic adhesion, platelet aggregation, and removal by activated lymphocytes of the lytic effect of ATP. Adenosine Diphosphate 112-115 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 43-47 9672245-2 1998 A 15 A deep pocket region in the N-terminal domain of Hsp90 serves as an ATP/ADP-binding site and has also been shown to bind geldanamycin, the only specific inhibitor of Hsp90 function described to date. Adenosine Diphosphate 77-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 54-59 9672245-2 1998 A 15 A deep pocket region in the N-terminal domain of Hsp90 serves as an ATP/ADP-binding site and has also been shown to bind geldanamycin, the only specific inhibitor of Hsp90 function described to date. Adenosine Diphosphate 77-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 171-176 9565569-7 1998 1321N1 human astrocytoma cells expressing the cloned P2X1 cDNA exhibited both ATP- and ADP-stimulated Ca2+ influx that could be blocked by the purinoceptor antagonist pyridoxalphosphate-6-azophenyl-2",4"-disulfonic acid and suramin. Adenosine Diphosphate 87-90 purinergic receptor P2X 1 Homo sapiens 53-57 9506960-2 1998 Here, we show that the DnaJ-triggered conversion of DnaK.ATP (T state) to DnaK.ADP.Pi (R state), as monitored by intrinsic protein fluorescence, is monophasic and occurs simultaneously with ATP hydrolysis. Adenosine Diphosphate 79-82 DnaJ Escherichia coli 23-27 9506960-8 1998 In the absence of GrpE, DnaJ forms a tight ternary complex with peptide.DnaK.ADP.Pi (Kd = 0.14 microM). Adenosine Diphosphate 77-80 DnaJ Escherichia coli 24-28 9526129-3 1998 Data are presented on the conformational changes which occur in the myosin head and in F-actin due to the formation of the ternary complexes with ADP and Pi analogs (such as orthovanadate, beryllium fluoride, or aluminum fluoride). Adenosine Diphosphate 146-149 myosin heavy chain 14 Homo sapiens 68-74 9568742-7 1998 In samples stimulated by ADP in vitro P-selectin expression increased by 45% (6%; 58%) after 3 h and by 30% (12%; 58%) (P<0.01 for both) after 6 h at 0.1 microM. Adenosine Diphosphate 25-28 selectin P Homo sapiens 38-48 9568742-8 1998 Platelet P-selectin expression was less influenced at higher ADP concentrations. Adenosine Diphosphate 61-64 selectin P Homo sapiens 9-19 9498802-0 1998 Role of P2Y1 purinoceptor in ADP-induced platelet activation. Adenosine Diphosphate 29-32 purinergic receptor P2Y1 Homo sapiens 8-12 9498802-3 1998 In order to determine if these P2Y1 receptors were involved in ADP-induced platelet activation, we determined the effects of A3P5PS, an antagonist of the P2Y1 receptor, on the binding of [33P]2-MeS-ADP, a potent analogue of ADP. Adenosine Diphosphate 63-66 purinergic receptor P2Y1 Homo sapiens 31-35 9498802-3 1998 In order to determine if these P2Y1 receptors were involved in ADP-induced platelet activation, we determined the effects of A3P5PS, an antagonist of the P2Y1 receptor, on the binding of [33P]2-MeS-ADP, a potent analogue of ADP. Adenosine Diphosphate 63-66 purinergic receptor P2Y1 Homo sapiens 31-44 9498802-3 1998 In order to determine if these P2Y1 receptors were involved in ADP-induced platelet activation, we determined the effects of A3P5PS, an antagonist of the P2Y1 receptor, on the binding of [33P]2-MeS-ADP, a potent analogue of ADP. Adenosine Diphosphate 198-201 purinergic receptor P2Y1 Homo sapiens 31-35 9498802-3 1998 In order to determine if these P2Y1 receptors were involved in ADP-induced platelet activation, we determined the effects of A3P5PS, an antagonist of the P2Y1 receptor, on the binding of [33P]2-MeS-ADP, a potent analogue of ADP. Adenosine Diphosphate 198-201 purinergic receptor P2Y1 Homo sapiens 31-44 9498802-6 1998 2-MeS-ADP-induced platelet aggregation was also inhibited by A3P5PS but was restored when platelets were further activated by serotonin, a non-aggregating compound, therefore suggesting that P2Y1-mediated stimulation is an absolute prerequisite for ADP to induce platelet aggregation and a key event for platelet activation and aggregation to occur. Adenosine Diphosphate 6-9 purinergic receptor P2Y1 Homo sapiens 191-195 9498802-7 1998 These results therefore show that ADP-induced aggregation cannot be attributed to activation of P2Y1 alone, but must be attributed to the simultaneous activation of the high affinity receptor (P2Y1) and a low affinity receptor of ADP (still to be discovered), each of them essential, but neither able to trigger aggregation alone. Adenosine Diphosphate 34-37 purinergic receptor P2Y1 Homo sapiens 96-100 9498802-7 1998 These results therefore show that ADP-induced aggregation cannot be attributed to activation of P2Y1 alone, but must be attributed to the simultaneous activation of the high affinity receptor (P2Y1) and a low affinity receptor of ADP (still to be discovered), each of them essential, but neither able to trigger aggregation alone. Adenosine Diphosphate 34-37 purinergic receptor P2Y1 Homo sapiens 193-197 9442040-14 1998 These results demonstrate the role of the P2Y1 receptor in ADP-induced platelet shape change and calcium mobilization and support the idea that several P2 receptors are involved in the regulation of different aspects of platelet stimulus-response coupling. Adenosine Diphosphate 59-62 purinergic receptor P2Y1 Homo sapiens 42-55 9425067-9 1998 These residues probably form contacts with each other on opposite sites of the beta sheet as well as with helix C. These increases appeared to represent localized fluctuations, rather than rigid body rearrangements, suggesting that MKK1 activation requires enhanced flexibility within the N-proximal lobe, perhaps to accommodate ATP binding, phosphotransfer, or ADP release. Adenosine Diphosphate 362-365 mitogen-activated protein kinase kinase 1 Homo sapiens 232-236 9889854-1 1998 Experimentally it is observed that the head regions of weakly-binding myosin crossbridges (crossbridges with ATP or ADP.Pi at the nucleotide binding site) are mobile while attached to actin, while strongly-binding crossbridge heads, such as those with PPi or AMP-PNP at the nucleotide binding site, are immobile (Pate and Cooke, Biophys. Adenosine Diphosphate 116-119 myosin heavy chain 14 Homo sapiens 70-76 9832332-5 1998 In contrast, botulinum toxin C, which mediates the ADP ribosylation of a 21 kD ras-related G protein, augmented IL-1beta-induced GMCSF mRNA expression. Adenosine Diphosphate 51-54 colony stimulating factor 2 Homo sapiens 129-134 23615440-4 2013 Grx5 binding does not stimulate the ATPase activity of Ssq1 and is most pronounced for the ADP-bound form of Ssq1, which interacts with Isu1 most tightly. Adenosine Diphosphate 91-94 glutaredoxin 5 Homo sapiens 0-4 18967031-3 1998 The kinetic parameters of hexokinase that were evaluated with the system were the apparent K(m)"s of the substrates glucose and ATP, and the K(i) of the competitive inhibitor for ATP, ADP. Adenosine Diphosphate 184-187 hexokinase Saccharomyces cerevisiae S288C 26-36 9459303-6 1997 In addition, FFA interact like their thioester derivatives in a structure-dependent manner with the ADP/ATP carrier (measured as inhibition of [3H]atractyloside binding to the AAC protein). Adenosine Diphosphate 100-103 glycine-N-acyltransferase Rattus norvegicus 176-179 23208703-3 2013 The ATP- and ADP-degrading capacity of cultured microglia depends on the expression of ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) and is several times higher when compared to astrocytes which lack this enzyme. Adenosine Diphosphate 13-16 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 87-136 9432026-8 1997 PLA formation by the platelet agonist ADP was inhibited by P-selectin blockade, but enhanced by GPIIb/IIIa blockade (which inhibits platelet-platelet interactions). Adenosine Diphosphate 38-41 selectin P Homo sapiens 59-69 23208703-3 2013 The ATP- and ADP-degrading capacity of cultured microglia depends on the expression of ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) and is several times higher when compared to astrocytes which lack this enzyme. Adenosine Diphosphate 13-16 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 138-142 23208703-4 2013 In brain slices, deletion of CD39 resulted in a 50 % decrease of ADP-degrading ability, while the degradation of ATP was decreased to about 75 % of the values measured in wild-type brain tissue. Adenosine Diphosphate 65-68 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 29-33 23601906-1 2013 The enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. Adenosine Diphosphate 197-200 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 28-32 9423802-3 1997 However, it has been suggested that the unique rapid calcium influx induced by ADP in platelets could involve P2X1 ionotropic receptors (MacKenzie et al. Adenosine Diphosphate 79-82 purinergic receptor P2X 1 Homo sapiens 110-114 23406164-4 2013 RESULTS: ADP induces a phosphoinositide 3-kinase (PI3K) pathway-dependent thrombin generation, presumably resulting from the cleavage of alphaII b beta3 -associated prothrombin. Adenosine Diphosphate 9-12 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 23-48 23650521-7 2013 At the same time, the mutation abolishes the actin-induced activation of ADP release and, in turn, slows down processive motility, especially when myosin experiences mechanical drag exerted by the action of multiple motor molecules bound to the same actin filament. Adenosine Diphosphate 73-76 myosin heavy chain 14 Homo sapiens 147-153 9398078-13 1997 However, in skinned fibers from the heart and m. soleus of transgenic desmin-deficient mice some changes in kinetics of respiration regulation by ADP were observed: in these fibers two populations of mitochondria were observed, one with usually high apparent Km for ADP and the second one with very low apparent Km for ADP. Adenosine Diphosphate 146-149 desmin Mus musculus 70-76 9402468-7 1997 The release of EDRF from the endothelium can be mediated by both pertussis toxin-sensitive (alpha 2-adrenoceptor activation, serotonin, aggregating platelets, leukotrienes) and insensitive (adenosine diphosphate (ADP), bradykinin) G proteins. Adenosine Diphosphate 190-211 alpha hemoglobin stabilizing protein Homo sapiens 15-19 9402468-7 1997 The release of EDRF from the endothelium can be mediated by both pertussis toxin-sensitive (alpha 2-adrenoceptor activation, serotonin, aggregating platelets, leukotrienes) and insensitive (adenosine diphosphate (ADP), bradykinin) G proteins. Adenosine Diphosphate 213-216 alpha hemoglobin stabilizing protein Homo sapiens 15-19 9351370-5 1997 Peripheral blood samples were analyzed for bound fibrinogen and expression of P-selectin, GPIb, and GPIIb-IIIa at rest and in response to ADP (0.1 to 10 mumol/L) and thrombin (0.02 to 0.32 mu/mL). Adenosine Diphosphate 138-141 selectin P Homo sapiens 78-88 23589853-8 2013 The results show that actin binding to the myosin.ADP.P complex straightens the relay helix before phosphate dissociation. Adenosine Diphosphate 50-53 myosin heavy chain 14 Homo sapiens 43-49 9295332-0 1997 The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. Adenosine Diphosphate 93-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-50 9364473-3 1997 The maximal effect observed for the P2Y1 receptor-selective agonists 2MeSATP and 2MeSADP was 65-70% of that observed with ATP, ADP, or 2ClATP, and the concentration effect curves for these two analogs were consistent with their interaction at a single site. Adenosine Diphosphate 85-88 purinergic receptor P2Y1 Homo sapiens 36-49 9364473-8 1997 Thus, HEK293 cells apparently express two subtypes of P2Y receptors that respond to ADP or ATP in an additive manner: a P2Y1 receptor, which is selectively activated by 2MeSADP, and a P2Y2 receptor, which is selectively activated by UTP. Adenosine Diphosphate 84-87 purinergic receptor P2Y1 Homo sapiens 120-133 23486472-6 2013 Analysis of EF2 in the mutant cells revealed a novel form of diphthamide with an additional methyl group that prevented ADP-ribosylation and inactivation of EF2. Adenosine Diphosphate 120-123 eukaryotic translation elongation factor 2 Homo sapiens 12-15 23331318-0 2013 Munc13-4 is critical for thrombosis through regulating release of ADP from platelets. Adenosine Diphosphate 66-69 unc-13 homolog D Homo sapiens 0-8 9136878-17 1997 On the other hand with non-native cations the predominant intermediate is the M* x ADP state and the release of ADP is the rate limiting step in the myosin-catalyzed ATP hydrolysis. Adenosine Diphosphate 83-86 myosin heavy chain 14 Homo sapiens 149-155 9136878-17 1997 On the other hand with non-native cations the predominant intermediate is the M* x ADP state and the release of ADP is the rate limiting step in the myosin-catalyzed ATP hydrolysis. Adenosine Diphosphate 112-115 myosin heavy chain 14 Homo sapiens 149-155 9168436-3 1997 DTctGMCSF was specifically immunoreactive with antidiphtheria toxin and anti-GMCSF antiseras, and exhibited the characteristic catalytic activity of diphtheria toxin, catalyzing the in vitro ADP-ribosylation of purified elongation factor 2. Adenosine Diphosphate 191-194 colony stimulating factor 2 Homo sapiens 4-9 23470885-7 2013 ADP-specific assays (ADP-LTA, the VASP index and VerifyNow-P2Y12) differed according to CYP2C19 genotype, with a significant gene-dose effect (PMs>IMs>EMs). Adenosine Diphosphate 0-3 WD and tetratricopeptide repeats 1 Homo sapiens 21-28 9168436-3 1997 DTctGMCSF was specifically immunoreactive with antidiphtheria toxin and anti-GMCSF antiseras, and exhibited the characteristic catalytic activity of diphtheria toxin, catalyzing the in vitro ADP-ribosylation of purified elongation factor 2. Adenosine Diphosphate 191-194 eukaryotic translation elongation factor 2 Homo sapiens 220-239 23590160-2 2013 Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration and enhances calcium-induced mitochondrial permeability transition pore (MPTP) opening. Adenosine Diphosphate 100-103 signal transducer and activator of transcription 3 Rattus norvegicus 42-47 9134654-8 1997 Similarly, the number of GPIIb-IIIa receptors capable of binding PAC-1 in response to ADP and TRAP was 50% to 80% greater in women than men. Adenosine Diphosphate 86-89 ADCYAP receptor type I Homo sapiens 65-70 23590160-2 2013 Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration and enhances calcium-induced mitochondrial permeability transition pore (MPTP) opening. Adenosine Diphosphate 100-103 signal transducer and activator of transcription 3 Rattus norvegicus 57-62 23487037-4 2013 Distortion or twisting of the central beta-sheet - proposed to trigger actin-induced Pi and ADP release by myosin, and microtubule-induced ADP release by kinesins - is shown in a movie depicting the transition between myosin ATP-like and nucleotide-free states. Adenosine Diphosphate 92-95 myosin heavy chain 14 Homo sapiens 107-113 23487037-4 2013 Distortion or twisting of the central beta-sheet - proposed to trigger actin-induced Pi and ADP release by myosin, and microtubule-induced ADP release by kinesins - is shown in a movie depicting the transition between myosin ATP-like and nucleotide-free states. Adenosine Diphosphate 92-95 myosin heavy chain 14 Homo sapiens 218-224 23487037-4 2013 Distortion or twisting of the central beta-sheet - proposed to trigger actin-induced Pi and ADP release by myosin, and microtubule-induced ADP release by kinesins - is shown in a movie depicting the transition between myosin ATP-like and nucleotide-free states. Adenosine Diphosphate 139-142 myosin heavy chain 14 Homo sapiens 218-224 23516601-6 2013 We demonstrate for the first time, for any ART derivative, that ADP NPs can down regulate the oncogenic protein HER2, and its counterpart, HER3 in a HER2+ cell line. Adenosine Diphosphate 64-67 erb-b2 receptor tyrosine kinase 2 Mus musculus 112-116 23516601-6 2013 We demonstrate for the first time, for any ART derivative, that ADP NPs can down regulate the oncogenic protein HER2, and its counterpart, HER3 in a HER2+ cell line. Adenosine Diphosphate 64-67 erb-b2 receptor tyrosine kinase 2 Mus musculus 149-153 23516601-7 2013 We also show that the wild type epidermal growth factor receptor (EGFR or HER1) declines in a triple negative breast cancer (TNBC) cell line in response to ADP NPs. Adenosine Diphosphate 156-159 epidermal growth factor receptor Mus musculus 32-64 23516601-7 2013 We also show that the wild type epidermal growth factor receptor (EGFR or HER1) declines in a triple negative breast cancer (TNBC) cell line in response to ADP NPs. Adenosine Diphosphate 156-159 epidermal growth factor receptor Mus musculus 66-70 22637533-0 2012 Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. Adenosine Diphosphate 26-29 adenylate kinase 1 Mus musculus 95-113 22637533-5 2012 We also showed that ~75% ADP in cell-free serum is metabolized via reversible AK1 reaction 2ADP ATP + AMP. Adenosine Diphosphate 25-28 adenylate kinase 1 Mus musculus 78-81 22637533-8 2012 In summary, we have identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides. Adenosine Diphosphate 178-181 adenylate kinase 1 Mus musculus 70-73 22809843-6 2012 Estimated glomerular filtration rate correlated inversely with platelet CD62P expression at rest (r=-0.22, p=0.004), and when stimulated by arachidonic acid (r=-0.21, p=0.007) and by adenosine diphosphate (r=-0.17, p=0.023). Adenosine Diphosphate 183-204 selectin P Homo sapiens 72-77 22947866-5 2012 In particular, even in the absence of external force, internal forces generated between myosin molecules in a large ensemble accelerate ADP release and increase how far actin moves during a single myosin attachment. Adenosine Diphosphate 136-139 myosin heavy chain 14 Homo sapiens 88-94 22517902-3 2012 A platelet signaling phenotype was obtained for 3 healthy donors using pairwise agonist scanning, in which calcium dye-loaded platelets were exposed to pairwise combinations of ADP, U46619, and convulxin to activate the P2Y(1)/P2Y(12), TP, and GPVI receptors, respectively, with and without the prostacyclin receptor agonist iloprost. Adenosine Diphosphate 177-180 purinergic receptor P2Y1 Homo sapiens 220-226 22547677-6 2012 Consistent with this, LPS stimulation-induced ADP-ribosylation at the nucleosome-occupied promoters of il-1beta, mip-2, and csf2 facilitates NF-kappaB recruitment and the transcription of these genes in macrophages. Adenosine Diphosphate 46-49 C-X-C motif chemokine ligand 2 Homo sapiens 113-118 22547677-6 2012 Consistent with this, LPS stimulation-induced ADP-ribosylation at the nucleosome-occupied promoters of il-1beta, mip-2, and csf2 facilitates NF-kappaB recruitment and the transcription of these genes in macrophages. Adenosine Diphosphate 46-49 colony stimulating factor 2 Homo sapiens 124-128 22628078-6 2012 FPP inhibited ADP-induced expression of P-selectin and the activated glycoprotein (Gp)IIb/IIIa receptor. Adenosine Diphosphate 14-17 selectin P Homo sapiens 40-50 22325929-13 2012 Interestingly, IGFBP-1 abrogated the potentiation of ADP-induced platelet aggregation triggered by IGF-1. Adenosine Diphosphate 53-56 insulin like growth factor binding protein 1 Homo sapiens 15-22 22335470-0 2012 Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration. Adenosine Diphosphate 37-40 adenosine A3 receptor Rattus norvegicus 0-21 9067502-5 1997 The combination of EPO, SCF, ADP, and epinephrine with TPO were synergistic for platelet CD62 expression. Adenosine Diphosphate 29-32 selectin P Homo sapiens 89-93 9134216-13 1997 These results show that a release of endogenous agonist activity (possibly ATP/ADP) from the P2Y1 expressing cells can create conditions in which a response to an agonist such as 2MeSATP can only be seen in the presence of a competitive antagonist. Adenosine Diphosphate 79-82 purinergic receptor P2Y1 Homo sapiens 93-97 9066009-5 1997 The stimulation of platelets with adenosine diphosphate showed the appearance of GD3 even in the absence of degranulation. Adenosine Diphosphate 34-55 GRDX Homo sapiens 81-84 9066009-6 1997 Finally, incorporation of pyrene-labeled GM3 into platelet membranes, followed by stimulation with adenosine diphosphate, resulted in the appearance of a fluorescent band comigrating with GD3. Adenosine Diphosphate 99-120 GRDX Homo sapiens 188-191 9005952-9 1997 Our results show that P-selectin expression on WP increases significantly upon stimulation with thrombin (0.1-1.0 U/ml), ADP (10 microM) and epinephrine (100 microM). Adenosine Diphosphate 121-124 selectin P Homo sapiens 22-32 8996251-4 1997 An additional thromboregulatory factor, ATP diphosphohydrolase (ATPDase; designated as EC 3.6.1.5) is also expressed by quiescent EC, and has the capacity to degrade the extracellular inflammatory mediators ATP and ADP to AMP, thereby inhibiting platelet activation and modulating vascular thrombosis. Adenosine Diphosphate 215-218 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 40-62 8996251-4 1997 An additional thromboregulatory factor, ATP diphosphohydrolase (ATPDase; designated as EC 3.6.1.5) is also expressed by quiescent EC, and has the capacity to degrade the extracellular inflammatory mediators ATP and ADP to AMP, thereby inhibiting platelet activation and modulating vascular thrombosis. Adenosine Diphosphate 215-218 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 64-71 9119254-4 1997 In rat liver microsomes (chosen as model membrane lipid substrate) exposed to GSH and ADP-chelated iron, the addition of GGT caused a marked stimulation of lipid peroxidation, which was further enhanced by the addition of the GGT co-substrate glycyl-glycine. Adenosine Diphosphate 86-89 gamma-glutamyltransferase 1 Rattus norvegicus 121-124 9119254-4 1997 In rat liver microsomes (chosen as model membrane lipid substrate) exposed to GSH and ADP-chelated iron, the addition of GGT caused a marked stimulation of lipid peroxidation, which was further enhanced by the addition of the GGT co-substrate glycyl-glycine. Adenosine Diphosphate 86-89 gamma-glutamyltransferase 1 Rattus norvegicus 226-229 9131407-15 1996 The P2Y6 receptor is activated most potently by UDP, but weakly or not at all by UTP, ADP and ATP. Adenosine Diphosphate 86-89 pyrimidinergic receptor P2Y6 Homo sapiens 4-17 8781562-2 1996 However, conversely, IPR treatment for 30 min caused a 40% increase in IAP-catalyzed ADP-ribosylation of Gi alpha, coupled with desensitization of amylase secretion. Adenosine Diphosphate 85-88 magnesium transporter 1 Rattus norvegicus 71-74 8781562-5 1996 These phenomena were accompanied with decreases in IAP-catalyzed ADP-ribosylation of Gi alpha. Adenosine Diphosphate 65-68 magnesium transporter 1 Rattus norvegicus 51-54 8781562-7 1996 Phosphorylation and dephosphorylation of immunoprecipitates with AS/7 by protein kinase A (PKA) and alkaline phosphatase caused decreases and increases in IAP-catalyzed ADP-ribosylation, respectively, indicating the presence of PKA-mediated phosphorylation sites on Gi2 alpha. Adenosine Diphosphate 169-172 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 73-89 8770115-7 1996 However, relaxation to the endothelium-dependent vasodilator ADP, which does not operate through a tyrosine kinase receptor, was reduced in the collateral-perfused region, compared with the normally perfused territory, suggesting a possible link of tyrosine kinase to the enhanced relaxations to VEGF and bFGF in collateral-perfused coronary microvessels. Adenosine Diphosphate 61-64 vascular endothelial growth factor A Sus scrofa 296-300 8694840-4 1996 Under limiting substrate concentration, the molar mass of ADP-ribosylated p53 was only slightly altered. Adenosine Diphosphate 58-61 transformation related protein 53, pseudogene Mus musculus 74-77 8738730-7 1996 After stimulation with ADP and epinephrine, expression of activation-dependent antigens was lower in platelets from patients (GMP 140: 0.64 +/- 0.09 vs 0.73 +/- 0.04, p = 0.02; GP 53: 0.41 +/- 0.13 vs 0.54 +/- 0.14). Adenosine Diphosphate 23-26 selectin P Homo sapiens 126-133 8730596-2 1996 Intracellular recordings in adult rat hippocampal slices were used to identify the ionic conductances underlying active spike after-depolarization (ADP) and intrinsic burst firing in the somata of CA1 pyramidal cells (PCs). Adenosine Diphosphate 148-151 carbonic anhydrase 1 Rattus norvegicus 197-200 8845766-6 1996 In the presence of ADP, mhsp70 can bind simultaneously to Tim44 and to a peptide substrate. Adenosine Diphosphate 19-22 translocase of inner mitochondrial membrane 44 Homo sapiens 58-63 22155453-6 2012 A correlation between platelet binding of 9E18 and P-selectin exposure was observed in patients experiencing coronary artery disease, and antagonists of the ADP receptor P2Y12 limited ADP-induced GPVI dimerization. Adenosine Diphosphate 157-160 glycoprotein VI platelet Homo sapiens 196-200 8709977-8 1996 The 24 kDa protein was distinct from the HEL cell, G25K/CDC42Hs GTP-binding protein and the GTP-binding protein that was a substrate for botulinum toxin C3 catalyzed ADP-ribosylation. Adenosine Diphosphate 166-169 hydroxycarboxylic acid receptor 3 Homo sapiens 92-111 22139586-1 2012 Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic elongation factor 2 (eEF2). Adenosine Diphosphate 86-89 eukaryotic translation elongation factor 2 Homo sapiens 176-206 8735836-0 1996 ADP-induced P-selectin expression on platelets as a predictor of successful thrombolysis. Adenosine Diphosphate 0-3 selectin P Homo sapiens 12-22 22139586-1 2012 Diphtheria toxin (DT) and its N-terminal fragment A (FA) catalyse the transfer of the ADP-ribose moiety of nicotinamide adenine dinucleotide (NAD) into a covalent linkage with eukaryotic elongation factor 2 (eEF2). Adenosine Diphosphate 86-89 eukaryotic translation elongation factor 2 Homo sapiens 208-212 22150949-10 2012 Significant inverse correlation existed between ADP and c-IMT on both sides (p<0.05). Adenosine Diphosphate 48-51 CIMT Homo sapiens 56-61 22150949-11 2012 Patients with c-IMT >0.6 mm had more AGH (p=0.012) and lower ADP levels (p=0.02). Adenosine Diphosphate 64-67 CIMT Homo sapiens 14-19 22150949-13 2012 Age, pre-ADP, and AGH were independent risk factors for elevated c-IMT. Adenosine Diphosphate 9-12 CIMT Homo sapiens 65-70 22155552-6 2012 Allosteric regulation by GTP, ATP and ADP of L3 and adult H. contortus and Teladorsagia circumcincta (Nematoda) GDH depended on the concentration of the regulators and the direction of the reaction. Adenosine Diphosphate 38-41 glutamate dehydrogenase 1 Homo sapiens 112-115 22729862-2 2012 A new regulation of respiration by the ATP/ADP ratio was introduced in eukaryotes based on nucleotide interaction with the added COX subunit IV. Adenosine Diphosphate 43-46 coproporphyrinogen oxidase Rattus norvegicus 129-132 22250198-4 2012 The objective of our study was to investigate the role of some different types of purinergic receptors, P2Y1, P2Y13 and P2X7, which are activated by ADP or ATP. Adenosine Diphosphate 149-152 purinergic receptor P2Y1 Homo sapiens 104-108 23272056-6 2012 The binding affinities of spastin and katanin were nucleotide-sensitive, with the lowest affinities under ADP,, the highest under ATP-gammaS conditions. Adenosine Diphosphate 106-109 Katanin 60 Drosophila melanogaster 38-45 23071564-7 2012 The forced expression of PKCepsilon in normal donor platelets significantly increased their response to adenosine diphosphate-induced activation and adhesion to subendothelial collagen. Adenosine Diphosphate 104-125 protein kinase C epsilon Homo sapiens 25-35 22038794-4 2012 Here, we offer the first high-resolution structure of hCINAP in complex with the substrate ADP (and dADP), the structure of hCINAP with a sulfate ion bound at the AMP binding site, and the structure of the ternary complex hCINAP-Mg(2+) ADP-Pi. Adenosine Diphosphate 91-94 adenylate kinase 6 Homo sapiens 54-60 22038794-4 2012 Here, we offer the first high-resolution structure of hCINAP in complex with the substrate ADP (and dADP), the structure of hCINAP with a sulfate ion bound at the AMP binding site, and the structure of the ternary complex hCINAP-Mg(2+) ADP-Pi. Adenosine Diphosphate 101-104 adenylate kinase 6 Homo sapiens 54-60 22261065-2 2011 Upon binding an MT, an Eg5 dimer releases one ADP molecule, undergoes a slow (~0.5 s(-1)) isomerization, and finally releases a second ADP, adopting a tightly MT-bound, nucleotide-free (APO) conformation. Adenosine Diphosphate 46-49 kinesin family member 11 Homo sapiens 23-26 22261065-2 2011 Upon binding an MT, an Eg5 dimer releases one ADP molecule, undergoes a slow (~0.5 s(-1)) isomerization, and finally releases a second ADP, adopting a tightly MT-bound, nucleotide-free (APO) conformation. Adenosine Diphosphate 135-138 kinesin family member 11 Homo sapiens 23-26 22261065-5 2011 We demonstrate that a critical element of Eg5, loop 5 (L5), accelerates ADP release during the initial MT-binding event. Adenosine Diphosphate 72-75 kinesin family member 11 Homo sapiens 42-45 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 94-97 mutS homolog 6 Homo sapiens 24-29 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 94-97 mutS homolog 6 Homo sapiens 120-125 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 105-118 mutS homolog 6 Homo sapiens 24-29 21937421-2 2011 Here we show that hMSH2-hMSH6 is strictly controlled by hMSH2 and magnesium in a complex with ADP (hMSH2(magnesium-ADP)-hMSH6). Adenosine Diphosphate 105-118 mutS homolog 6 Homo sapiens 120-125 21937421-3 2011 Destabilization of magnesium results in ADP release from hMSH2 that allows high affinity ATP binding by hMSH6, which then enhances ATP binding by hMSH2. Adenosine Diphosphate 40-43 mutS homolog 6 Homo sapiens 104-109 21484092-13 2011 The A(2A) agonist CGS21680 and the P2Y(1) receptor antagonist MRS2500 were derivatized for covalent attachment to polyamidoamine dendrimeric carriers of MW 20,000, and the resulting multivalent conjugates inhibited ADP-promoted platelet aggregation. Adenosine Diphosphate 215-218 purinergic receptor P2Y1 Homo sapiens 35-50 8735836-4 1996 In the present study no significant differences were observed in P-selectin expression before and after any of the procedures, except that P-selectin expression following ADP stimulation was reduced in patients who had received conventional thrombolysis. Adenosine Diphosphate 171-174 selectin P Homo sapiens 139-149 8735836-5 1996 Unexpectedly, we observed relatively greater P-selectin expression, particularly after ADP stimulation, both before and following thrombolysis in ten patients in whom thrombolysis was successful compared with six patients in whom thrombolysis was unsuccessful. Adenosine Diphosphate 87-90 selectin P Homo sapiens 45-55 8735836-6 1996 ADP-induced P-selectin expression on platelets may therefore be a useful predictor of outcome of peripheral intra-arterial thrombolysis. Adenosine Diphosphate 0-3 selectin P Homo sapiens 12-22 8645282-1 1996 Internal flexibility of myosin heads in glycerinated muscle fibres in the presence of MgADP plus orthovanadate and after addition of Ca-ATP was studied using an isothiocyanate-based spin label attached to the reactive sulfhydryl sites of myosin. Adenosine Diphosphate 86-91 myosin heavy chain 14 Homo sapiens 24-30 8573186-14 1996 Pertussis toxin-catalyzed ADP-ribosylation of alpha-subunits may inhibit the transfer of GTP from NDPK to G-proteins. Adenosine Diphosphate 26-29 cytidine/uridine monophosphate kinase 2 Homo sapiens 98-102 8621673-5 1996 We conclude that human platelets possess a P2X1 purinoceptor, which mediates a rapid phase of ADP- or ATP-evoked Ca2+ entry via a cation channel, whereas one or more separate ADP-selective P2 purinoceptors evoke release of calcium from intracellular stores. Adenosine Diphosphate 94-97 purinergic receptor P2X 1 Homo sapiens 43-47 8565173-5 1996 METHODS AND RESULTS: In conscious and anesthetized mongrel dogs, DMP 728 at 0.02 to 1.0 mg/kg PO in gelatin capsules produced dose-dependent antiplatelet effects in inhibiting ex vivo platelet aggregation induced by ADP and prolonging template bleeding time. Adenosine Diphosphate 216-219 mastin Canis lupus familiaris 65-68 8548904-8 1996 At a constant MgATP concentration (1 mmol/L), the inhibitory effect of MgADP on the actin-myosin interaction was weaker in the presence of CK than in the absence of CK. Adenosine Diphosphate 71-76 myosin heavy chain 14 Homo sapiens 90-96 9001693-7 1996 The reduced platelet activation after ADP and U 46619 persisted at day 4 both with PAC-1 and with anti-GMP-140. Adenosine Diphosphate 38-41 selectin P Homo sapiens 103-110 8973769-5 1996 However, anti-ANT antibody can inhibit the ADP/ATP exchange of heart mitochondria and be organ-specific. Adenosine Diphosphate 43-46 solute carrier family 25 member 6 Homo sapiens 14-17 9090846-0 1996 Oxygen- and carbon source-dependent transactivation effect of ABF1 on the expression of the AAC2 gene encoding mitochondrial ADP/ATP carrier. Adenosine Diphosphate 125-128 musculin Homo sapiens 62-66 21043595-4 1996 ADP alone caused a significant and sustained increase in the cytoskeletal content of actin binding protein (ABP), myosin, alpha-actinin, a 66K protein and actin, and a significant decrease in a 31K protein. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 114-120 8530456-2 1995 CD38 is a lymphocyte differentiation antigen which has recently been shown to be a bifunctional enzyme that can synthesize cADPR from NAD+ as well as hydrolyze cADPR to ADP-ribose. Adenosine Diphosphate 124-127 CD38 molecule Homo sapiens 0-4 8554519-4 1995 This effect of ADP was concentration dependent and inhibited by the class P2 purinoceptor (P2T) antagonist ATP. Adenosine Diphosphate 15-18 pyrimidinergic receptor P2Y6 Homo sapiens 74-89 8772233-17 1995 ADP activation of normal platelets gave PAC-1 binding, but no significant annexin V labelling, nor production of microvesicles. Adenosine Diphosphate 0-3 ADCYAP receptor type I Homo sapiens 40-45 8562903-3 1995 The resulting diphtheria toxin-related cytokine fusion proteins, or fusion toxins bind to their respective receptors, are internalized by receptor-mediated endocytosis, and efficiently eliminate target cell populations by the adenosine diphosphate ribosylation of elongation factor 2. Adenosine Diphosphate 226-247 eukaryotic translation elongation factor 2 Homo sapiens 264-283 7619043-7 1995 A major difference between the two maize hexokinase forms is that only the mitochondrial enzyme was strongly inhibited by ADP (Ki 0.04 mM). Adenosine Diphosphate 122-125 hexokinase 2 Zea mays 41-51 7619043-11 1995 We now show that the membrane-bound hexokinase and glucose 6-phosphate can also serve as an ATP regenerating system for the mitochondria of maize radicles provided that the ADP concentration is kept below 0.05 mM. Adenosine Diphosphate 173-176 hexokinase 2 Zea mays 36-46 7619043-12 1995 Higher ADP concentrations inhibit the reverse reaction of the mitochondrial hexokinase. Adenosine Diphosphate 7-10 hexokinase 2 Zea mays 76-86 21632028-3 2011 A selective P2Y(1) receptor agonist, the ADP analogue MRS2365, concentration-dependently induced intracellular calcium mobilization (EC(50) 5.28nM), which was diminished by P2Y(1) receptor-selective antagonist MRS2500. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 12-27 7760334-0 1995 Structural studies on corn nitrate reductase: refined structure of the cytochrome b reductase fragment at 2.5 A, its ADP complex and an active-site mutant and modeling of the cytochrome b domain. Adenosine Diphosphate 117-120 nitrate reductase [NADH] 1 Zea mays 27-44 7760334-1 1995 The refined crystal structures of the recombinant cytochrome b reductase fragment of corn (Zea mays) nitrate reductase, its ADP complex and the active-site mutant Cys242Ser are reported here. Adenosine Diphosphate 124-127 nitrate reductase [NADH] 1 Zea mays 101-118 21632028-3 2011 A selective P2Y(1) receptor agonist, the ADP analogue MRS2365, concentration-dependently induced intracellular calcium mobilization (EC(50) 5.28nM), which was diminished by P2Y(1) receptor-selective antagonist MRS2500. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 173-188 21424266-9 2011 The EP(4)-antagonist AE3-208 (1-3 muM) potentiated in combination with PGE(2) (1 muM) ADP-induced aggregation, demonstrating that PGE(2) enhances platelet aggregation when the inhibitory EP(4)-receptor is inactivated. Adenosine Diphosphate 86-89 prostaglandin E receptor 4 Homo sapiens 4-9 7767791-1 1995 Myosin is an ATPase enzyme with the unique property that the hydrolysis and release of Pi and ADP is coupled to movement via a cyclic interaction between myosin and actin filaments. Adenosine Diphosphate 94-97 myosin heavy chain 14 Homo sapiens 0-6 7767791-1 1995 Myosin is an ATPase enzyme with the unique property that the hydrolysis and release of Pi and ADP is coupled to movement via a cyclic interaction between myosin and actin filaments. Adenosine Diphosphate 94-97 myosin heavy chain 14 Homo sapiens 154-160 21600693-5 2011 The selective P2Y(1) receptor antagonist MRS2179 largely attenuated the excitatory effects of ADP, but left those of 2-thio-UTP unaltered. Adenosine Diphosphate 94-97 purinergic receptor P2Y1 Homo sapiens 14-29 7521896-9 1994 Translocation of P-selectin in plasma-suspended platelets in response to increasing doses of adenosine diphosphate (ADP) occurred in a dose-dependent manner and correlated positively with ADP-induced platelet aggregation in terms of both stimulating doses of ADP (r = 0.99, p < 0.01) and time intervals (r = 0.92, p < 0.05). Adenosine Diphosphate 93-114 selectin P Homo sapiens 17-27 7521896-9 1994 Translocation of P-selectin in plasma-suspended platelets in response to increasing doses of adenosine diphosphate (ADP) occurred in a dose-dependent manner and correlated positively with ADP-induced platelet aggregation in terms of both stimulating doses of ADP (r = 0.99, p < 0.01) and time intervals (r = 0.92, p < 0.05). Adenosine Diphosphate 116-119 selectin P Homo sapiens 17-27 7521896-9 1994 Translocation of P-selectin in plasma-suspended platelets in response to increasing doses of adenosine diphosphate (ADP) occurred in a dose-dependent manner and correlated positively with ADP-induced platelet aggregation in terms of both stimulating doses of ADP (r = 0.99, p < 0.01) and time intervals (r = 0.92, p < 0.05). Adenosine Diphosphate 188-191 selectin P Homo sapiens 17-27 21713327-9 2011 However, for both drugs, pre-treatment reactivity to ADP predicted 6 h, 18-24 h and 15 day reactivity to ADP (correlations 0.24-0.62 for platelet-monocyte aggregates and P-selectin). Adenosine Diphosphate 53-56 selectin P Homo sapiens 170-180 7521896-9 1994 Translocation of P-selectin in plasma-suspended platelets in response to increasing doses of adenosine diphosphate (ADP) occurred in a dose-dependent manner and correlated positively with ADP-induced platelet aggregation in terms of both stimulating doses of ADP (r = 0.99, p < 0.01) and time intervals (r = 0.92, p < 0.05). Adenosine Diphosphate 188-191 selectin P Homo sapiens 17-27 21713327-9 2011 However, for both drugs, pre-treatment reactivity to ADP predicted 6 h, 18-24 h and 15 day reactivity to ADP (correlations 0.24-0.62 for platelet-monocyte aggregates and P-selectin). Adenosine Diphosphate 105-108 selectin P Homo sapiens 170-180 21498885-10 2011 ARH3-catalyzed hydrolysis of OAADPr in H(2)(18)O resulted in incorporation of one (18)O into ADP-ribose by mass spectrometric analysis, consistent with cleavage at the C-1"" position. Adenosine Diphosphate 31-34 ADP-ribosylserine hydrolase Homo sapiens 0-4 7521212-5 1994 Many physiological and pathological effectors, including Ca2+ and ADP, modulate MTP operation directly through changes of the gating potential rather than indirectly through changes of the membrane potential (Petronilli, V., Cola, C., Massari, S., Colonna, R. and Bernardi, P. (1993) J. Biol. Adenosine Diphosphate 66-69 metallothionein 1B Homo sapiens 80-83 8076642-0 1994 ADP-induced changes in ordering of spin-labelled myosin heads in muscle fibres. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 49-55 21576651-2 2011 The P2Y(1) receptor for adenosine 5"-diphosphate has been shown to be involved in the development of atherosclerosis in apolipoprotein E--deficient mice. Adenosine Diphosphate 24-48 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 4-19 8043603-3 1994 Previous work has shown that PRS I is more sensitive to inhibition by ADP and GDP and more stable to heat treatment than is PRS II. Adenosine Diphosphate 70-73 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 29-34 8043603-8 1994 Lys-4 was also important for the strong ADP inhibition of PRS I. Adenosine Diphosphate 40-43 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 58-63 8055911-6 1994 Polymerization of skeletal muscle actin from the complex with thymosin beta 4 by phalloidin is accompanied by the hydrolysis of the actin-bound ATP to ADP. Adenosine Diphosphate 151-154 actin, beta Gallus gallus 34-39 8055911-6 1994 Polymerization of skeletal muscle actin from the complex with thymosin beta 4 by phalloidin is accompanied by the hydrolysis of the actin-bound ATP to ADP. Adenosine Diphosphate 151-154 actin, beta Gallus gallus 132-137 21576266-5 2011 Using in vitro reconstitution assays, we found here that Nup159 is specifically required for ADP release from Dbp5. Adenosine Diphosphate 93-96 DEAD-box helicase 19B Homo sapiens 110-114 21576266-7 2011 In vivo, a dbp5-R256D/R259D mutant with reduced ADP binding bypasses the need for Nup159 interaction. Adenosine Diphosphate 48-51 DEAD-box helicase 19B Homo sapiens 11-15 12232248-6 1994 In the presence of Triton X-100 the H+-ATPase catalyzes the cleavage of glucose-6-phosphate when both hexokinase and ADP are included in the assay medium. Adenosine Diphosphate 117-120 ATPase Zea mays 39-45 8062509-10 1994 Platelet responsiveness to ADP in vitro showed a heightened degranulation response (CD63 expression) in normal pregnancy compared with the non-pregnant control group, which was increased further in women with non-proteinuric and proteinuric pre-eclampsia. Adenosine Diphosphate 27-30 CD63 molecule Homo sapiens 84-88 8053944-5 1994 Increase in ADP-ribosylation of 22 and 24 kDa substrates and their interaction with photoexcited rhodopsin in squid photoreceptors was found. Adenosine Diphosphate 12-15 rhodopsin Bos taurus 97-106 21576266-9 2011 Further analysis reveals that remodeling requires a conformational shift to the Dbp5-ADP form. Adenosine Diphosphate 85-88 DEAD-box helicase 19B Homo sapiens 80-84 21373747-0 2011 cAMP regulates ADP-induced HSP27 phosphorylation in human platelets. Adenosine Diphosphate 15-18 heat shock protein family B (small) member 1 Homo sapiens 27-32 8163488-6 1994 A subset of preproteins including the ADP/ATP carrier and the phosphate carrier interact with very high affinity, precursors that are known to be targeted via MOM72. Adenosine Diphosphate 38-41 protein channel TOM70 Saccharomyces cerevisiae S288C 159-164 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 30-51 heat shock protein family B (small) member 1 Homo sapiens 85-106 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 30-51 heat shock protein family B (small) member 1 Homo sapiens 108-113 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 53-56 heat shock protein family B (small) member 1 Homo sapiens 85-106 21373747-2 2011 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p38 mitogen-activated protein (MAP) kinase is correlated with platelet-derived growth factor (PDGF)-AB secretion and soluble CD40 ligand (sCD40L) release. Adenosine Diphosphate 53-56 heat shock protein family B (small) member 1 Homo sapiens 108-113 8017760-3 1994 Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. Adenosine Diphosphate 30-51 alpha hemoglobin stabilizing protein Homo sapiens 74-109 8017760-3 1994 Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. Adenosine Diphosphate 30-51 alpha hemoglobin stabilizing protein Homo sapiens 111-115 21373747-5 2011 In addition, the ADP-induced HSP27 phosphorylation was suppressed by 8-bromo-cAMP or cilostazol. Adenosine Diphosphate 17-20 heat shock protein family B (small) member 1 Homo sapiens 29-34 8017760-3 1994 Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. Adenosine Diphosphate 53-56 alpha hemoglobin stabilizing protein Homo sapiens 74-109 8017760-3 1994 Vasodilatation is mediated by adenosine diphosphate (ADP), which releases endothelium-derived relaxing factor (EDRF) from endothelium. Adenosine Diphosphate 53-56 alpha hemoglobin stabilizing protein Homo sapiens 111-115 8017760-12 1994 Leukocytes also release oxygen radicals, which may inactivate EDRF, thereby impairing ADP-mediated, endothelium-dependent vasodilator responses. Adenosine Diphosphate 86-89 alpha hemoglobin stabilizing protein Homo sapiens 62-66 21373747-7 2011 These results strongly suggest that cAMP regulates ADP-stimulated platelet activation due to inhibition of HSP27 phosphorylation via p38 MAP kinase. Adenosine Diphosphate 51-54 heat shock protein family B (small) member 1 Homo sapiens 107-112 21532989-1 2011 The adenine nucleotide translocase (ANT) mediates the exchange of ADP and ATP across the inner mitochondrial membrane. Adenosine Diphosphate 66-69 solute carrier family 25 member 6 Homo sapiens 36-39 8147900-1 1994 The effects of the P2-purinoceptor antagonist, suramin, on ADP-induced increases in human platelet cytosolic calcium concentration ([Ca2+]i) and inhibition of prostaglandin E1 (PGE1)-stimulated adenylate cyclase activity were investigated. Adenosine Diphosphate 59-62 pyrimidinergic receptor P2Y6 Homo sapiens 19-34 8118033-13 1994 The role that G proteins play in mediating the intracellular signaling pathways induced by GM-CSF or IL-2 in human T cells is supported by adenosine diphosphate-ribosylation of a 44-kD or a 39-kD G protein in T-cell membranes by CT and PT, respectively. Adenosine Diphosphate 139-160 colony stimulating factor 2 Homo sapiens 91-97 21315083-4 2011 Our kinetic results demonstrate that the NBP goes from a closed to an open conformation prior to the release of ADP, while the actin-binding cleft remains closed. Adenosine Diphosphate 112-115 NUBP iron-sulfur cluster assembly factor 1, cytosolic Homo sapiens 41-44 8056761-6 1994 The brain hsp90 inhibited beta gamma-supported pertussis toxin-catalyzed ADP-ribosylation of alpha subunits. Adenosine Diphosphate 73-76 heat shock protein 90 alpha family class A member 1 Homo sapiens 10-15 21315083-8 2011 Our experimental and modeling studies support the conclusion of a novel post-power-stroke actomyosin.ADP state in which the NBP and actin-binding cleft are closed. Adenosine Diphosphate 101-104 NUBP iron-sulfur cluster assembly factor 1, cytosolic Homo sapiens 124-127 21330475-5 2011 PAR1-activating peptide (PAR1-AP), adenosine diphosphate (via P2Y1/P2Y12), and glycoprotein VI-targeting collagen-related peptide induced massive SDF-1alpha and VEGF but modest PF4 or no endostatin release. Adenosine Diphosphate 35-56 purinergic receptor P2Y1 Homo sapiens 62-66 8005102-0 1994 Adenine nucleotides regulate ADP-ribosylation of membrane-bound actin and actin-binding to membranes. Adenosine Diphosphate 29-32 actin Oryctolagus cuniculus 64-69 21270334-1 2011 The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory. Adenosine Diphosphate 4-7 poly(ADP-ribose) polymerase family member 3 Homo sapiens 58-63 8005102-1 1994 Adenine nucleotides were shown to increase the ADP-ribosylation of actin by Clostridium perfringens iota and Clostridium botulinum C2 toxin in membranes from human platelets, hamster fat cells, rat liver- and rat brain cells. Adenosine Diphosphate 47-50 actin Oryctolagus cuniculus 67-72 8005102-6 1994 [32P]ADP-ribosylated rabbit skeletal muscle actin, which is unable to polymerize, was used as tool to study membrane-binding of actin. Adenosine Diphosphate 5-8 actin Oryctolagus cuniculus 44-49 8005102-6 1994 [32P]ADP-ribosylated rabbit skeletal muscle actin, which is unable to polymerize, was used as tool to study membrane-binding of actin. Adenosine Diphosphate 5-8 actin Oryctolagus cuniculus 128-133 21270334-1 2011 The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation, a key posttranslational modification of proteins involved in different signaling pathways from DNA damage to energy metabolism and organismal memory. Adenosine Diphosphate 4-7 poly(ADP-ribose) polymerase family member 3 Homo sapiens 64-69 8294438-3 1994 Down-regulation of protein kinase C by phorbol esters or pertussis toxin catalyzed ADP-ribosylation of Gi proteins inhibits thrombin and ATP receptor-stimulated MAP kinase and arachidonic acid release, indicating that functional protein kinase C and Gi proteins are required for G protein regulation of arachidonic acid release. Adenosine Diphosphate 83-86 purinergic receptor P2X 2 Homo sapiens 137-149 7506054-3 1994 ADP caused concentration-dependent increases in the percentage of platelets that bound fibrinogen (from 4.4 +/- 0.9% to 69.9 +/- 4.2%) and that expressed P-selectin (from 4.5 +/- 0.5% to 44.2 +/- 3.8%). Adenosine Diphosphate 0-3 selectin P Homo sapiens 154-164 8281661-5 1994 METHODS AND RESULTS: DMP 728 demonstrated antiplatelet efficacy in vitro in inhibiting ADP-induced human platelet aggregation (IC50, 46 +/- 2 nmol/L) and fibrinogen binding to human platelets (IC50, 2.3 +/- 0.8 nmol/L) or purified human GPIIb/IIIa receptors (IC50, 0.6 +/- 0.1 nmol/L). Adenosine Diphosphate 87-90 mastin Canis lupus familiaris 21-24 8281661-7 1994 In anesthetized mongrel dogs, DMP 728 at 0.001 to 1.0 mg/kg IV produced dose-dependent antiplatelet effects in inhibiting ex vivo platelet aggregation induced by ADP and in prolonging template bleeding time. Adenosine Diphosphate 162-165 mastin Canis lupus familiaris 30-33 8244957-6 1993 Labeling under optimal conditions was at least 0.4 mol of ADP-ribose/mol of integrin alpha 7. Adenosine Diphosphate 58-61 integrin alpha 7 Mus musculus 76-92 20946295-6 2011 Following ADP stimulation, the percentage of both CD62P and PAC1 positive platelets increased in a dose dependent fashion, even 8 h after the blood was collected. Adenosine Diphosphate 10-13 selectin P Homo sapiens 50-55 21241967-9 2011 Platelet stimulation with ADP exhibited significantly lower CD62p-positive cell population (%) in the diabetic patients both prior to and following the exercise stress test (P = .03). Adenosine Diphosphate 26-29 selectin P Homo sapiens 60-65 7689042-9 1993 P-selectin expression and fibrinogen binding were found after the addition of cocaine alone to blood taken from some but not all donors; however, platelet activation in response to submaximal concentrations of the agonists ADP or epinephrine was enhanced by a low concentration of cocaine added to blood from every donor. Adenosine Diphosphate 223-226 selectin P Homo sapiens 0-10 22022533-6 2011 The platelet antagonists [cangrelor, MRS2179, and apyrase] inhibited 59M cell induced activation suggesting a P2Y12 and P2Y1 receptor mediated mechanism of platelet activation dependent on the release of ADP by 59M cells. Adenosine Diphosphate 204-207 purinergic receptor P2Y1 Homo sapiens 120-133 21063242-2 2010 Pericellular adenosine is generated by the hydrolysis of extracellular adenosine triphosphate and adenosine diphosphate by the ectonucleotidase CD39 and the subsequent hydrolysis of adenosine monophosphate (AMP) by the ectonucleotidase CD73. Adenosine Diphosphate 98-119 5' nucleotidase, ecto Mus musculus 236-240 20975043-2 2010 Nicotinamide adenine dinucleotide (NAD(+)) released during cell damage or inflammation results in ART2.2-mediated ADP-ribosylation of the cytolytic P2X7 receptor on T cells. Adenosine Diphosphate 114-117 ADP-ribosyltransferase 2b Mus musculus 98-104 20628048-9 2010 Inhibition of both human GDHs by estrogens was inversely related to their state of activation induced by ADP, with the slope of this correlation being steeper for hGDH2 than for hGDH1. Adenosine Diphosphate 105-108 glutamate dehydrogenase 1 Homo sapiens 178-183 20702811-4 2010 RvE1, 0.1 to 100 nmol/L, incubated with platelets gave reduced ADP-stimulated P-selectin mobilization (IC(50), approximately 1.6x10(-12) mol/L) and polymerized actin content compared with control platelets. Adenosine Diphosphate 63-66 selectin P Homo sapiens 78-88 20702811-9 2010 CONCLUSIONS: RvE1"s regulatory actions (ie, reducing ADP-stimulated P-selectin mobilization and actin polymerization) are human (h)ChemR23-dependent. Adenosine Diphosphate 53-56 selectin P Homo sapiens 68-78 20681951-0 2010 TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 76-80 20681951-5 2010 Then, we found that migratory capability and expression of both P2Y receptors were abrogated in microglial cells from LPS-stimulated mixed glial cultures, while TGF-beta increased ADP-induced migration and the expression of P2Y12 and P2Y1 receptors. Adenosine Diphosphate 180-183 purinergic receptor P2Y1 Homo sapiens 224-228 20635416-3 2010 We have solved the structure of the N-terminal ATP-binding domain of P. falciparum Hsp90, which contains a principal drug-binding pocket, in both apo and ADP-bound states at 2.3 A resolution. Adenosine Diphosphate 154-157 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-88 20835845-7 2010 Alteration of Ssa1 structure between ATP- and ADP-bound states regulates its function. Adenosine Diphosphate 46-49 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 14-18 20664890-7 2010 AE1-329 also inhibited adenosine diphosphate-induced platelet aggregation, and the inhibition was almost completely blocked by AE3-208, an EP4 antagonist. Adenosine Diphosphate 23-44 prostaglandin E receptor 4 Homo sapiens 139-142 20526761-10 2010 P2Y(13) antagonism through MRS2211 per se increased the secretion of both insulin and glucagon at intermediate (8.3 mmol/l) and high (20 mmol/l) glucose levels, confirming an autocrine role for ADP. Adenosine Diphosphate 194-197 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 0-7 20526761-12 2010 CONCLUSIONS/INTERPRETATION: In conclusion, ADP acting on the P2Y(13) receptors inhibits insulin release. Adenosine Diphosphate 43-46 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 61-68 20718861-7 2010 In an in vitro assay, intact ETA induced ADP-ribosylation of EF-2 and mitochondrial release of cytochrome c, with the former effect being efficiently increased by a cathepsin B/cathepsin D pretreatment. Adenosine Diphosphate 41-44 cathepsin B Rattus norvegicus 165-176 20617074-8 2010 In our study, PGC-1alpha reduced cell apoptosis and ROS generation in endothelial cells by increasing ATP/ADP translocase activity of ANT and ANT1 expression. Adenosine Diphosphate 106-109 PPARG coactivator 1 alpha Sus scrofa 14-24 20348099-4 2010 CO directly modulates ANT function by enhancing ADP/ATP exchange and prevents its pore-forming activity. Adenosine Diphosphate 48-51 solute carrier family 25 member 6 Homo sapiens 22-25 20178980-1 2010 CD39 is a transmembrane enzyme that inhibits platelet reactivity and inflammation by phosphohydrolyzing ATP and ADP to AMP. Adenosine Diphosphate 112-115 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 8335808-8 1993 RESULTS: Receptor site blockade and inhibition of platelet aggregation to 20 mumol/liter adenosine diphosphate were maximal at a dose of 0.25 mg/kg body weight of m7E3 Fab. Adenosine Diphosphate 89-110 FA complementation group B Homo sapiens 168-171 20361728-0 2010 Phosphorylation of the transcription factor Ets-1 by ERK2: rapid dissociation of ADP and phospho-Ets-1. Adenosine Diphosphate 81-84 ETS proto-oncogene 1, transcription factor Homo sapiens 44-49 20361728-12 2010 These data suggest that koff may be limited by the dissociation of both products and are consistent with the notion that Ets-1 has evolved to be an efficient substrate for ERK2, where ADP release is, at least, partially rate-limiting. Adenosine Diphosphate 184-187 ETS proto-oncogene 1, transcription factor Homo sapiens 121-126 20135752-9 2010 Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Adenosine Diphosphate 142-145 selectin P Homo sapiens 167-172 8393092-2 1993 In resting dystrophin-deficient muscle, there was a decrease in phosphocreatine (PCr) and increase in orthophosphate (Pi) relative to ATP, and an increase in calculated free [ADP]. Adenosine Diphosphate 175-178 dystrophin Homo sapiens 11-21 20135752-12 2010 The groups were similar in basal and ADP-stimulated platelet CD62P expression (P values >0.05). Adenosine Diphosphate 37-40 selectin P Homo sapiens 61-66 20135752-13 2010 Basal and ADP-stimulated CD62P expression, PMC and PNC were not significantly different between active Behcet"s disease versus inactive Behcet"s disease patients. Adenosine Diphosphate 10-13 selectin P Homo sapiens 25-30 8441181-5 1993 Both phosphorylated TnI and TnT inhibited the Ca(2+)-stimulated binding of S-1.ADP to regulated actin, consistent with the notion that the effects of phosphorylation of TnI and TnT affected interactions of the thin filament with the thick filament. Adenosine Diphosphate 79-82 troponin I3, cardiac type Rattus norvegicus 20-23 1386527-2 1992 These compounds, like orthovanadate, form stable complexes with myosin subfragment 1 (S1) in the presence of MgADP. Adenosine Diphosphate 109-114 myosin heavy chain 14 Homo sapiens 64-70 20076852-6 2010 In the stroke patients the increased expressions of P-selectin and active GP IIb/IIIa in TRAP- or ADP-activated cells were less pronounced (p<0.01), while the increments in PMP fraction remained higher (p<0.05). Adenosine Diphosphate 98-101 selectin P Homo sapiens 52-62 1378836-1 1992 The adenine nucleotide translocator (ANT) catalyzes the exchange of ADP and ATP across the mitochondrial internal membrane. Adenosine Diphosphate 68-71 solute carrier family 25 member 6 Homo sapiens 4-35 1378836-1 1992 The adenine nucleotide translocator (ANT) catalyzes the exchange of ADP and ATP across the mitochondrial internal membrane. Adenosine Diphosphate 68-71 solute carrier family 25 member 6 Homo sapiens 37-40 19247849-7 2010 Only in a subgroup of ADP, those without psychiatric co-diagnoses and homozygous for A10, significantly lower scores in novelty seeking and higher scores in self directedness than in all the other ADP and CO could be detected. Adenosine Diphosphate 22-25 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 85-88 1514698-3 1992 Examination of the binding profile of tritium-labeled PAF to these platelets in the presence or absence of ADP revealed significant difference in the Kd values but not in the number of specific binding sites. Adenosine Diphosphate 107-110 PCNA clamp associated factor Homo sapiens 54-57 1323554-3 1992 The present evidence indicates that EF2 prebound to ribosomes is protected from phosphorylation, just as earlier evidence indicated that ribosome-bound EF2 is protected from ADP-ribosylation catalysed by diphtheria toxin. Adenosine Diphosphate 174-177 eukaryotic translation elongation factor 2 Homo sapiens 36-39 1323554-3 1992 The present evidence indicates that EF2 prebound to ribosomes is protected from phosphorylation, just as earlier evidence indicated that ribosome-bound EF2 is protected from ADP-ribosylation catalysed by diphtheria toxin. Adenosine Diphosphate 174-177 eukaryotic translation elongation factor 2 Homo sapiens 152-155 19247849-7 2010 Only in a subgroup of ADP, those without psychiatric co-diagnoses and homozygous for A10, significantly lower scores in novelty seeking and higher scores in self directedness than in all the other ADP and CO could be detected. Adenosine Diphosphate 197-200 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 85-88 20067476-8 2010 In vitro, the concentration-response curves of relaxation to ADP and ATP were shifted to the left, revealing a facilitation of endothelial P2Y1 and P2Y2 receptor activation in Entpd1(-/-) mice. Adenosine Diphosphate 61-64 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 139-143 1581508-8 1992 Data are also presented for effects of MgADP on the orientation of labeled myosin subfragment 1 bound to actin in myofibrils. Adenosine Diphosphate 39-44 myosin heavy chain 14 Homo sapiens 75-81 19717402-11 2010 The factor also reduced ADP-induced expression of platelet P-selectin, indicating reduction of platelet activity. Adenosine Diphosphate 24-27 selectin P Homo sapiens 59-69 1310031-3 1992 The EPR spectra from fibers with the fiber axis oriented at 90 degrees to the Zeeman field show a clear spectral shift from the rigor spectrum when the myosin cross-bridge binds MgADP. Adenosine Diphosphate 178-183 myosin heavy chain 14 Homo sapiens 152-158 19875381-0 2010 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Adenosine Diphosphate 89-92 heat shock protein 90 alpha family class A member 1 Homo sapiens 46-51 1731882-4 1992 Tubulin and MAP-2 incorporated [14C]ADP-ribose to an average extent of approximately 2.4 and 30 mol of ADP-ribose/mol of protein, respectively. Adenosine Diphosphate 36-39 microtubule associated protein 2 Bos taurus 12-17 19875381-0 2010 A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. Adenosine Diphosphate 89-92 heat shock protein 90 alpha family class A member 1 Homo sapiens 103-108 1731882-4 1992 Tubulin and MAP-2 incorporated [14C]ADP-ribose to an average extent of approximately 2.4 and 30 mol of ADP-ribose/mol of protein, respectively. Adenosine Diphosphate 103-106 microtubule associated protein 2 Bos taurus 12-17 19875381-2 2010 Here we use tandem affinity purification and LC-MS/MS to investigate the proteome-wide effects of ATP, ADP, and geldanamycin on the constituents of the human HSP90 interactome. Adenosine Diphosphate 103-106 heat shock protein 90 alpha family class A member 1 Homo sapiens 158-163 19875381-5 2010 We further characterized a novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1. Adenosine Diphosphate 33-36 heat shock protein 90 alpha family class A member 1 Homo sapiens 47-52 19812088-1 2010 A conventional five-step chemo-mechanical cycle of the myosin-actin ATPase reaction, which implies myosin detachment from actin upon release of hydrolysis products (ADP and phosphate, Pi) and binding of a new ATP molecule, is able to fit the [Pi] dependence of the force and number of myosin motors during isometric contraction of skeletal muscle. Adenosine Diphosphate 165-168 myosin heavy chain 14 Homo sapiens 55-61 1731754-2 1992 This ADP-ribosylation was stimulated dose-dependently by 14,15-epoxyeicosatrienoic acid (14,15-EET), one of the metabolites of arachidonic acid by NADPH-dependent cytochrome P-450 mono-oxygenase. Adenosine Diphosphate 5-8 cytochrome P450, family 2, subfamily j, polypeptide 3 Rattus norvegicus 163-194 19812088-1 2010 A conventional five-step chemo-mechanical cycle of the myosin-actin ATPase reaction, which implies myosin detachment from actin upon release of hydrolysis products (ADP and phosphate, Pi) and binding of a new ATP molecule, is able to fit the [Pi] dependence of the force and number of myosin motors during isometric contraction of skeletal muscle. Adenosine Diphosphate 165-168 myosin heavy chain 14 Homo sapiens 99-105 19812088-1 2010 A conventional five-step chemo-mechanical cycle of the myosin-actin ATPase reaction, which implies myosin detachment from actin upon release of hydrolysis products (ADP and phosphate, Pi) and binding of a new ATP molecule, is able to fit the [Pi] dependence of the force and number of myosin motors during isometric contraction of skeletal muscle. Adenosine Diphosphate 165-168 myosin heavy chain 14 Homo sapiens 99-105 21152446-7 2010 Moreover, GDP and ADP exhibited a competitive kinetic behavior with respect to ANT. Adenosine Diphosphate 18-21 solute carrier family 25 member 6 Homo sapiens 79-82 1931944-1 1991 The active-site topology of smooth muscle myosin has been investigated by direct photoaffinity-labeling studies with [3H]ADP. Adenosine Diphosphate 121-124 myosin heavy chain 14 Homo sapiens 42-48 1717069-7 1991 When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not. Adenosine Diphosphate 67-70 selectin P Homo sapiens 131-138 21170421-4 2010 This is consistent with previous data showing recycling of ADP and ATP inside the MI due to the functional coupling between MtCK and ANT and limited permeability of VDAC for these compounds, PCr being the major energy carrier between the mitochondria and ATPases. Adenosine Diphosphate 59-62 solute carrier family 25 member 6 Homo sapiens 133-136 1716077-4 1991 In addition, we compared the GMP-140 expression with platelet aggregation in response to adenosine diphosphate (ADP). Adenosine Diphosphate 89-110 selectin P Homo sapiens 29-36 1716077-4 1991 In addition, we compared the GMP-140 expression with platelet aggregation in response to adenosine diphosphate (ADP). Adenosine Diphosphate 112-115 selectin P Homo sapiens 29-36 1859469-9 1991 The effects of ADP, AMP, and adenine on cTnI phosphorylation are also described. Adenosine Diphosphate 15-18 troponin I3, cardiac type Rattus norvegicus 40-44 1742357-0 1991 Effect of ADP-ribosylation and phosphorylation on the interaction of elongation factor 2 with guanylic nucleotides. Adenosine Diphosphate 10-13 eukaryotic translation elongation factor 2 Homo sapiens 69-88 19858214-5 2009 The GST pull-down assay and ELISA assay show that Cdc37 binds to ADP-bound/nucleotide-free Hsp90 but not ATP-bound Hsp90. Adenosine Diphosphate 65-68 heat shock protein 90 alpha family class A member 1 Homo sapiens 91-96 1871721-5 1991 This resulted in a shift of C1/C2, so that the effect of collagen was more pronounced (maximal increase of C1/C2 = 134%) than ADP (maximal increase of C1/C2 = 79%). Adenosine Diphosphate 126-129 complement C2 Rattus norvegicus 28-33 19890703-2 2009 DISCUSSION: The key role of platelet-mediated thrombosis in the pathogenesis of NSTE ACS is confirmed by the proven clinical benefits of antiplatelet agents (aspirin and a P2Y(12) adenosine diphosphate [ADP] receptor antagonist) in this setting. Adenosine Diphosphate 180-201 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 85-88 1755363-3 1991 The SPOC condition and the space-time pattern of SPOC wave suggest that the dynamics of association and dissociation of Pi (ADP) is regulated by the mechanical strain imposed on actin and myosin; the enzymatic activity (ATPase) of actomyosin complex and the mechanical event (contraction) are thus coupled to each other. Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 188-194 19740098-5 2009 CONCLUSIONS: These results indicate that genetic polymorphisms in ITGA2 and P2RY1 combine with plasma VWF:Ag levels to modulate baseline platelet reactivity in response to collagen plus EPI, while genetic differences in P2RY1 and GP1BA significantly effect platelet responses to collagen plus ADP. Adenosine Diphosphate 293-296 purinergic receptor P2Y1 Homo sapiens 76-81 19751672-0 2009 Force and premature binding of ADP can regulate the processivity of individual Eg5 dimers. Adenosine Diphosphate 31-34 kinesin family member 11 Homo sapiens 79-82 21047285-5 1991 Both the intact IgC and its Fab fragments were found to inhibit platelet aggregation and secretion induced by ADP or collagen in platelet-rich plasma and by thrombin in platelet suspensions. Adenosine Diphosphate 110-113 FA complementation group B Homo sapiens 28-31 19751672-1 2009 Using a high-resolution optical trapping instrument, we directly observed the processive motions of individual Eg5 dimers over a range of external loads and ATP, ADP, and phosphate concentrations. Adenosine Diphosphate 162-165 kinesin family member 11 Homo sapiens 111-114 19751672-4 2009 At a constant moderate force, maintained with a force clamp, the premature binding of ADP strongly promoted microtubule release by Eg5, whereas the addition of ATP or phosphate had little effect on dissociation. Adenosine Diphosphate 86-89 kinesin family member 11 Homo sapiens 131-134 19631608-0 2009 Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation. Adenosine Diphosphate 28-31 serpin family C member 1 Homo sapiens 0-16 2177474-1 1990 We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing. Adenosine Diphosphate 109-112 protein channel TOM70 Saccharomyces cerevisiae S288C 60-65 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 30-51 heat shock protein family B (small) member 1 Homo sapiens 85-106 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 30-51 heat shock protein family B (small) member 1 Homo sapiens 108-113 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 53-56 heat shock protein family B (small) member 1 Homo sapiens 85-106 2229042-0 1990 Transmission of ADP.vanadate-induced conformational changes to three peptide segments of myosin subfragment-1. Adenosine Diphosphate 16-19 myosin heavy chain 14 Homo sapiens 89-95 19631608-3 2009 We have previously shown that adenosine diphosphate (ADP)-induced phosphorylation of heat shock protein 27 (HSP27) via p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK is correlated with platelet granule secretion. Adenosine Diphosphate 53-56 heat shock protein family B (small) member 1 Homo sapiens 108-113 19631608-4 2009 In the present study, we investigated the relationship between AT-III and the ADP-induced platelet granule secretion. Adenosine Diphosphate 78-81 serpin family C member 1 Homo sapiens 63-69 19631608-5 2009 The ADP-induced secretion of platelet-derived growth factor (PDGF)-AB and serotonin (5-HT) were significantly suppressed by AT-III. Adenosine Diphosphate 4-7 serpin family C member 1 Homo sapiens 124-130 19631608-8 2009 AT-III markedly attenuated the ADP-induced phosphorylation levels of p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 31-34 serpin family C member 1 Homo sapiens 0-6 2170106-3 1990 Anti-MAS70 IgGs or removal of MAS70 from the mitochondria by either mild trypsin treatment or by disrupting the nuclear MAS70 gene inhibits import of the F1-ATPase beta-subunit, the ADP/ATP translocator, and of several other precursors into isolated mitochondria by up to 75%, but has little effect on the import of porin. Adenosine Diphosphate 182-185 protein channel TOM70 Saccharomyces cerevisiae S288C 5-10 2170106-3 1990 Anti-MAS70 IgGs or removal of MAS70 from the mitochondria by either mild trypsin treatment or by disrupting the nuclear MAS70 gene inhibits import of the F1-ATPase beta-subunit, the ADP/ATP translocator, and of several other precursors into isolated mitochondria by up to 75%, but has little effect on the import of porin. Adenosine Diphosphate 182-185 protein channel TOM70 Saccharomyces cerevisiae S288C 30-35 19631608-9 2009 Furthermore, the ADP-induced HSP27 phosphorylation was suppressed by AT-III. Adenosine Diphosphate 17-20 heat shock protein family B (small) member 1 Homo sapiens 29-34 2170106-3 1990 Anti-MAS70 IgGs or removal of MAS70 from the mitochondria by either mild trypsin treatment or by disrupting the nuclear MAS70 gene inhibits import of the F1-ATPase beta-subunit, the ADP/ATP translocator, and of several other precursors into isolated mitochondria by up to 75%, but has little effect on the import of porin. Adenosine Diphosphate 182-185 protein channel TOM70 Saccharomyces cerevisiae S288C 30-35 19631608-9 2009 Furthermore, the ADP-induced HSP27 phosphorylation was suppressed by AT-III. Adenosine Diphosphate 17-20 serpin family C member 1 Homo sapiens 69-75 2170106-5 1990 Removal of MAS70 from wild-type mitochondria inhibits binding of the ADP/ATP translocator to the mitochondrial surface, indicating that MAS70 mediates one of the earliest import steps. Adenosine Diphosphate 69-72 protein channel TOM70 Saccharomyces cerevisiae S288C 11-16 2170106-5 1990 Removal of MAS70 from wild-type mitochondria inhibits binding of the ADP/ATP translocator to the mitochondrial surface, indicating that MAS70 mediates one of the earliest import steps. Adenosine Diphosphate 69-72 protein channel TOM70 Saccharomyces cerevisiae S288C 136-141 19631608-10 2009 These results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 85-88 serpin family C member 1 Homo sapiens 36-42 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 139-161 endothelin-3 Oryctolagus cuniculus 59-63 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 163-166 endothelin-3 Oryctolagus cuniculus 59-63 2127021-1 1990 Endothelin (ET)-1 (0.1-1 nmol/kg), ET-2 (0.1-1 nmol/kg) or ET-3 (0.3-3 nmol/kg) dose dependently inhibited platelet aggregation induced by adenosine di-phosphate (ADP) ex vivo in anaesthetised rabbits, while having no effect on aggregations induced by ADP, collagen or arachidonic acid in vitro. Adenosine Diphosphate 252-255 endothelin-3 Oryctolagus cuniculus 59-63 2259199-7 1990 If the final A.M.ATP state has a sufficiently lower tension than that of A.M.ADP.Pi, then the dominant escape path from the intermediate state is shown to be direct dissociation of the actin-myosin bond. Adenosine Diphosphate 77-80 myosin heavy chain 14 Homo sapiens 191-197 19631608-10 2009 These results strongly suggest that AT-III directly acts on platelets and suppresses ADP-induced platelet granule secretion due to inhibiting HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK. Adenosine Diphosphate 85-88 heat shock protein family B (small) member 1 Homo sapiens 142-147 2253264-14 1990 Finally, ADP reversed the phencyclidine-induced block of ACh currents in oocytes expressing muscle nAChR. Adenosine Diphosphate 9-12 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 99-104 19464286-2 2009 The synthesis of adenosine involves the catabolism of adenine nucleotides (ATP, ADP and AMP) by the action of extracellular ectonucleotidases i.e. CD39 or nucleoside triphosphate dephosphorylase (NTPD) and CD73 or 5"-ectonucleotidase. Adenosine Diphosphate 80-83 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 147-151 2318846-1 1990 The effect of ADP-ribosylation on the function of eukaryotic elongation factor 2 (EF-2) was investigated by kinetic analysis of the EF-2-catalyzed hydrolysis of GTP in the presence of ribosomes and by direct determination of the affinity of the modified factor for the ribosome. Adenosine Diphosphate 14-17 eukaryotic translation elongation factor 2 Homo sapiens 61-80 2318846-1 1990 The effect of ADP-ribosylation on the function of eukaryotic elongation factor 2 (EF-2) was investigated by kinetic analysis of the EF-2-catalyzed hydrolysis of GTP in the presence of ribosomes and by direct determination of the affinity of the modified factor for the ribosome. Adenosine Diphosphate 14-17 eukaryotic translation elongation factor 2 Homo sapiens 82-86 2318846-1 1990 The effect of ADP-ribosylation on the function of eukaryotic elongation factor 2 (EF-2) was investigated by kinetic analysis of the EF-2-catalyzed hydrolysis of GTP in the presence of ribosomes and by direct determination of the affinity of the modified factor for the ribosome. Adenosine Diphosphate 14-17 eukaryotic translation elongation factor 2 Homo sapiens 132-136 2318846-2 1990 Under conditions where the concentration of EF-2 was rate-limiting, the ADP-ribosylation reduced the maximum rate of GTP hydrolysis and the second order rate constant Kcat/Km by approximately 50%. Adenosine Diphosphate 72-75 eukaryotic translation elongation factor 2 Homo sapiens 44-48 2318846-4 1990 The affinity of EF-2 for the pretranslocation type of ribosomes was reduced by 2 orders of magnitude after ADP-ribosylation. Adenosine Diphosphate 107-110 eukaryotic translation elongation factor 2 Homo sapiens 16-20 18812468-2 2009 Adenosine triphosphate/adenosine diphosphate is metabolized to adenosine through a 2-step enzymatic reaction initiated by CD39 (ectonucleoside-triphosphate-diphosphohydrolase-1). Adenosine Diphosphate 23-44 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 122-126 2346758-1 1990 It has been shown that a fast increase in pH of myosin solution leads to ATP formation de novo from ADP and Pi (about one ATP molecule per one myosin molecule). Adenosine Diphosphate 100-103 myosin heavy chain 14 Homo sapiens 48-54 2346758-1 1990 It has been shown that a fast increase in pH of myosin solution leads to ATP formation de novo from ADP and Pi (about one ATP molecule per one myosin molecule). Adenosine Diphosphate 100-103 myosin heavy chain 14 Homo sapiens 143-149 18812468-2 2009 Adenosine triphosphate/adenosine diphosphate is metabolized to adenosine through a 2-step enzymatic reaction initiated by CD39 (ectonucleoside-triphosphate-diphosphohydrolase-1). Adenosine Diphosphate 23-44 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 128-176 19560753-2 2009 Hsp90 inhibitors cause the inactivation, destabilization and eventual degradation of Hsp90 client proteins through occupying the ATP/ADP binding pocket of Hsp90. Adenosine Diphosphate 133-136 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 19560753-2 2009 Hsp90 inhibitors cause the inactivation, destabilization and eventual degradation of Hsp90 client proteins through occupying the ATP/ADP binding pocket of Hsp90. Adenosine Diphosphate 133-136 heat shock protein 90 alpha family class A member 1 Homo sapiens 85-90 19560753-2 2009 Hsp90 inhibitors cause the inactivation, destabilization and eventual degradation of Hsp90 client proteins through occupying the ATP/ADP binding pocket of Hsp90. Adenosine Diphosphate 133-136 heat shock protein 90 alpha family class A member 1 Homo sapiens 85-90 19122661-2 2009 PBP-induced reductions in the rate constants for ATP binding, ATP hydrolysis and ADP dissociation extend the time required per myosin ATPase cycle in the absence and presence of actin. Adenosine Diphosphate 81-84 myosin heavy chain 14 Homo sapiens 127-133 19013524-2 2008 The signalling protein PII, an ancient and widely distributed nitrogen/carbon/ADP/ATP sensor, mediates feedback inhibition relief of NAGK by binding to this enzyme. Adenosine Diphosphate 78-81 N-acetylglucosamine kinase Homo sapiens 133-137 2143799-0 1990 Visualization of adenosinetriphosphatase site of myosin using photoreactive adenosine 5"-diphosphate analog. Adenosine Diphosphate 76-100 myosin heavy chain 14 Homo sapiens 49-55 33234590-5 2021 Furthermore, wild-type myosin containing STFs, but not S1, HMM, or STFs-containing R403Q myosin, recapitulated the ADP-induced destabilization of the SRX state. Adenosine Diphosphate 115-118 myosin heavy chain 14 Homo sapiens 23-29 33234590-7 2021 Importantly, we also found that pathophysiological perturbations such as elevated ADP concentration weakens the mavacamten"s ability to increase the myosin SRX population, suggesting that mavacamten-bound myosin heads are not permanently protected in the SRX state but can be recruited into action. Adenosine Diphosphate 84-87 myosin heavy chain 14 Homo sapiens 151-157 33234590-7 2021 Importantly, we also found that pathophysiological perturbations such as elevated ADP concentration weakens the mavacamten"s ability to increase the myosin SRX population, suggesting that mavacamten-bound myosin heads are not permanently protected in the SRX state but can be recruited into action. Adenosine Diphosphate 84-87 myosin heavy chain 14 Homo sapiens 207-213 34922916-4 2022 Here, CD39 first converts ATP and adenosine diphosphate(ADP) into AMP, after which AMP is dephosphorylated into adenosine by CD73. Adenosine Diphosphate 56-59 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 6-10 34688677-5 2021 In vivo experiments suggested that ADP significantly inhibited the tumor growth of mice, increased the activities of spleen lymphocytes and natural killer (NK) cells, improved the cytokine level (IL-2 and TNF-alpha) and the proportions of lymphocyte subsets in the peripheral blood. Adenosine Diphosphate 35-38 interleukin 2 Mus musculus 196-200 34860335-9 2021 In the pathway, gene-set analysis, the linkage rs471683 and rs7785386 of GNAI1 GNAT3 were associated with PRU and ADP aggregation rate, 18-month and 30-month ISR, and repeat revascularization within 30 months. Adenosine Diphosphate 114-117 G protein subunit alpha i1 Homo sapiens 73-78 34860335-10 2021 Rs1715389 of GNAI1 GNAT3 was associated with both PRU and ADP aggregation rate, 18-month and 30-month ISR, and repeat revascularization within 30 months. Adenosine Diphosphate 58-61 G protein subunit alpha i1 Homo sapiens 13-18 34697820-3 2021 CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine. Adenosine Diphosphate 124-127 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 34711681-7 2021 Molecular dynamics simulations reveal MgADP-dependent dynamic tripartite interactions between this linker, SUR2B, and Kir6.1. Adenosine Diphosphate 38-43 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 118-124 34675608-1 2021 Introduction: ENPP1 and ENTPD1 are two main enzymes involved in ATP-AMP-ADP-adenosine axis, which is associated with lipid metabolism, diabetes mellitus (DM) and renal fibrosis. Adenosine Diphosphate 72-75 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 24-30 19013524-3 2008 PII phosphorylation or PII binding of ADP or 2-oxoglutarate prevents PII-NAGK complex formation. Adenosine Diphosphate 38-41 N-acetylglucosamine kinase Homo sapiens 73-77 18675894-5 2008 ATP-, UTP-, ADP-, 2-MeS-ATP- and ADP-betaS-induced proliferation in P19 cells was mediated by P2Y(1) and P2Y(2) receptors as judged from pharmacological profiles of receptor responses. Adenosine Diphosphate 12-15 purinergic receptor P2Y1 Homo sapiens 94-100 18636751-5 2008 We found that the cdk5/p25-catalyzed phosphorylation of tau follows a rapid equilibrium, random kinetic mechanism, as evidenced by initial velocity analysis indicating sequential addition of tau and ATP, and studies of the mechanism of inhibition by substrate analogue AMP, product ADP, and analogues of peptide substrate H1P. Adenosine Diphosphate 282-285 cyclin dependent kinase 5 Homo sapiens 18-22 18550799-4 2008 In vitro experiments with OOC-5, a torsinA homolog from Caenorhabditis elegans, demonstrate that redox changes that reduce this disulfide bond affect the binding of ATP and ADP and cause an attendant local conformational change detected by limited proteolysis. Adenosine Diphosphate 173-176 torsin family 1 member A Homo sapiens 35-42 18791938-6 2008 ADP and TRAP induced an increased percentage of CD62P expression and PAC-1 binding after platelet transfusions compared to the samples studied before transfusion, and these findings were lower than those of the healthy controls. Adenosine Diphosphate 0-3 selectin P Homo sapiens 48-53 18791938-6 2008 ADP and TRAP induced an increased percentage of CD62P expression and PAC-1 binding after platelet transfusions compared to the samples studied before transfusion, and these findings were lower than those of the healthy controls. Adenosine Diphosphate 0-3 ADCYAP receptor type I Homo sapiens 69-74 18673269-3 2008 Based on the discovery that bisphosphate analogues of the P2Y(1) receptor agonist, ADP, are partial agonists/competitive antagonists of this receptor, an iterative approach was used to develop competitive antagonists with enhanced affinity and selectivity. Adenosine Diphosphate 83-86 purinergic receptor P2Y1 Homo sapiens 58-73 18276159-7 2008 All examined states of the H+,K+-ATPase, including the E1 and E1P x ADP states present in the 2D crystals,showed characteristic differences in the digestion patterns. Adenosine Diphosphate 68-71 small nucleolar RNA, H/ACA box 73A Homo sapiens 55-65 18397738-2 2008 A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA. Adenosine Diphosphate 48-51 DEAD-box helicase 19B Homo sapiens 18-22 18218635-4 2008 The interaction triggers release of bound ADP from Ssa1, but nucleotide persists bound to Sse1 in the complex. Adenosine Diphosphate 42-45 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 51-55 17984174-3 2008 Galectin-1 binds to human platelets in a carbohydrate-dependent manner and synergizes with ADP or thrombin to induce platelet aggregation and ATP release. Adenosine Diphosphate 91-94 galectin 1 Homo sapiens 0-10 17984174-7 2008 Finally, expression of endogenous galectin-1 in human platelets contributes to ADP-induced aggregation. Adenosine Diphosphate 79-82 galectin 1 Homo sapiens 34-44 17949747-6 2007 Crystal structures of Saccharomyces cerevisiae Vps4 in both the nucleotide-free form and the ADP-bound form provide the first structural view illustrating how nucleotide binding might induce conformational changes within Vps4 that lead to oligomerization and binding to its substrate ESCRT-III subunits. Adenosine Diphosphate 93-96 AAA family ATPase VPS4 Saccharomyces cerevisiae S288C 47-51 17949747-6 2007 Crystal structures of Saccharomyces cerevisiae Vps4 in both the nucleotide-free form and the ADP-bound form provide the first structural view illustrating how nucleotide binding might induce conformational changes within Vps4 that lead to oligomerization and binding to its substrate ESCRT-III subunits. Adenosine Diphosphate 93-96 AAA family ATPase VPS4 Saccharomyces cerevisiae S288C 221-225 17960245-8 2007 To test whether ADP (the product of E-NTPDase2) might act to trigger eye development through P2Y1 receptors, selective in Xenopus for ADP, we simultaneously knocked down expression of the genes encoding E-NTPDase2 and the P2Y1 receptor. Adenosine Diphosphate 16-19 purinergic receptor P2Y, G-protein coupled, 1 S homeolog Xenopus laevis 93-97 17960245-8 2007 To test whether ADP (the product of E-NTPDase2) might act to trigger eye development through P2Y1 receptors, selective in Xenopus for ADP, we simultaneously knocked down expression of the genes encoding E-NTPDase2 and the P2Y1 receptor. Adenosine Diphosphate 134-137 purinergic receptor P2Y, G-protein coupled, 1 S homeolog Xenopus laevis 93-97 17681941-1 2007 The adenine nucleotide translocases (Ant) facilitate the transport of ADP and ATP by an antiport mechanism across the inner mitochondrial membrane, thus playing an essential role in cellular energy metabolism. Adenosine Diphosphate 70-73 solute carrier family 25 member 6 Homo sapiens 37-40 17681941-3 2007 The conservation of Ant4 in mammals, along with the absence of Ant4 in nonmammalian species, suggests a unique and indispensable role for this ADP/ATP carrier in mammalian development. Adenosine Diphosphate 143-146 solute carrier family 25 member 31 Homo sapiens 20-24 17681941-10 2007 Considering the unique conservation and chromosomal location of the Ant family genes in mammals, the Ant4 gene may have arisen in mammalian ancestors and been conserved in mammals to serve as the sole and essential mitochondrial ADP/ATP carrier during spermatogenesis where the sex chromosome-linked Ant2 gene is inactivated. Adenosine Diphosphate 229-232 solute carrier family 25 member 31 Homo sapiens 101-105 17681941-10 2007 Considering the unique conservation and chromosomal location of the Ant family genes in mammals, the Ant4 gene may have arisen in mammalian ancestors and been conserved in mammals to serve as the sole and essential mitochondrial ADP/ATP carrier during spermatogenesis where the sex chromosome-linked Ant2 gene is inactivated. Adenosine Diphosphate 229-232 solute carrier family 25 member 6 Homo sapiens 300-304 17714854-6 2007 The FRET efficiencies observed after ADP or TRAP platelet activation changed less than 20% from the resting values, showing that the distance between the labeled Fab fragments changes only modestly after platelet activation by physiological agonists. Adenosine Diphosphate 37-40 FA complementation group B Homo sapiens 162-165 34479984-0 2021 Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response. Adenosine Diphosphate 57-60 ADP-ribosylserine hydrolase Homo sapiens 10-17 34479984-7 2021 This minimally affects basal ADP ribosylation but results in elevated nuclear ADP ribosylation during stress, demonstrating the vital role of ADP ribosylation reversal by ARH3 in DNA damage control. Adenosine Diphosphate 29-32 ADP-ribosylserine hydrolase Homo sapiens 171-175 34479984-7 2021 This minimally affects basal ADP ribosylation but results in elevated nuclear ADP ribosylation during stress, demonstrating the vital role of ADP ribosylation reversal by ARH3 in DNA damage control. Adenosine Diphosphate 78-81 ADP-ribosylserine hydrolase Homo sapiens 171-175 34479984-7 2021 This minimally affects basal ADP ribosylation but results in elevated nuclear ADP ribosylation during stress, demonstrating the vital role of ADP ribosylation reversal by ARH3 in DNA damage control. Adenosine Diphosphate 142-145 ADP-ribosylserine hydrolase Homo sapiens 171-175 34480694-5 2022 Accordingly, the arthritis mouse model had more neutrophils in inflamed joints following ADP injection, whereas P2Y1 deficiency and pharmacologic inhibition restored arthritis severity to basal levels, suggesting a dominant role of ADP/P2Y1 signaling in RA pathology. Adenosine Diphosphate 89-92 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 236-240 34504490-4 2021 We evaluated the impact of ADP-ribosylation on the capability of CD73 to generate adenosine from adenosine monophosphate. Adenosine Diphosphate 27-30 5' nucleotidase, ecto Mus musculus 65-69 34264286-2 2021 ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L). Adenosine Diphosphate 90-93 poly(ADP-ribose) polymerase family member 9 Homo sapiens 36-41 34264286-2 2021 ADP-ribosylated AR is recognized by PARP9/DTX3L, a heterodimeric complex that contains an ADP-ribose reader (PARP9) and a ubiquitin E3 ligase (DTX3L). Adenosine Diphosphate 90-93 poly(ADP-ribose) polymerase family member 9 Homo sapiens 109-114 34291079-9 2021 Furthermore, ADP stimulated alveolar epithelial cells to secrete chemokine CXCL10 by activating P2Y1 receptor, whereby promoting asthma airway inflammation. Adenosine Diphosphate 13-16 purinergic receptor P2Y1 Homo sapiens 96-109 34291079-11 2021 As a "danger signal" extracellular ADP could trigger and maintain airway inflammation in asthma by activating P2Y1 receptor. Adenosine Diphosphate 35-38 purinergic receptor P2Y1 Homo sapiens 110-123 34752329-2 2021 These include A1 and A2A adenosine receptors, and P2Y1 and P2Y12 receptors that respond to ADP and other nucleotides. Adenosine Diphosphate 91-94 purinergic receptor P2Y1 Homo sapiens 50-54 17626796-2 2007 The ectoenzyme nucleoside-triphosphate diphosphohydrolase-1 (NTPDase1) catalyzes the dual dephosphorylation of ATP and ADP to AMP. Adenosine Diphosphate 119-122 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 15-59 35523115-14 2022 CONCLUSIONS: ADP administration improves PTSD-like behaviors in mice and this effect may be mediated through an mTOR-dependent improvement in synaptic function in the hippocampus. Adenosine Diphosphate 13-16 mechanistic target of rapamycin kinase Mus musculus 112-116 35606662-7 2022 Then, the ANT model was incorporated into a simple, yet effective, empirical model of mitochondrial bioenergetics to ascertain the point when Ca2+ overload initiates PTP opening via an ANT switch-like mechanism activated by matrix Ca2+ and is inhibited by extra-mitochondrial ADP. Adenosine Diphosphate 276-279 solute carrier family 25 member 6 Homo sapiens 10-13 35606662-7 2022 Then, the ANT model was incorporated into a simple, yet effective, empirical model of mitochondrial bioenergetics to ascertain the point when Ca2+ overload initiates PTP opening via an ANT switch-like mechanism activated by matrix Ca2+ and is inhibited by extra-mitochondrial ADP. Adenosine Diphosphate 276-279 solute carrier family 25 member 6 Homo sapiens 185-188 17626796-2 2007 The ectoenzyme nucleoside-triphosphate diphosphohydrolase-1 (NTPDase1) catalyzes the dual dephosphorylation of ATP and ADP to AMP. Adenosine Diphosphate 119-122 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 61-69 17560607-3 2007 The nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), also known as CD39, is a plasma membrane-bound ectoenzyme that hydrolyzes extracellular ATP and ADP to AMP. Adenosine Diphosphate 157-160 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 50-58 35502901-9 2022 Additionally, these PTMs have potential to modulate interactions between beta-MHC and other regulatory sarcomeric proteins, ADP-release rate of myosin, flexibility of the S2 region, and cardiac myofilament contractility in normal and heart failure hearts. Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 144-150 17560607-3 2007 The nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), also known as CD39, is a plasma membrane-bound ectoenzyme that hydrolyzes extracellular ATP and ADP to AMP. Adenosine Diphosphate 157-160 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 75-79 17229526-4 2007 Fructose-2,6-bisphosphate (fru-2,6-P(2)) converted the saturation curves for fru-6-P to hyperbolic, activated PFKM synergistically with other positive effectors of the enzyme such as AMP and ADP, and counteracted ATP and citrate inhibition. Adenosine Diphosphate 191-194 phosphofructokinase, muscle Homo sapiens 110-114 17393024-10 2007 On ADP-stimulated platelets the thresholds for P-selectin expression and GP IIb/IIa activation are 34.0 degrees C and 36.4 degrees C, respectively, and lie in the temperature range routinely applied in cardiac surgery. Adenosine Diphosphate 3-6 selectin P Homo sapiens 47-57 17155953-1 2007 BACKGROUND: Activation of two receptors for adenosine diphosphate (ADP), P2Y(1) and P2Y(12), is necessary for ADP-induced platelet aggregation (PA). Adenosine Diphosphate 44-65 purinergic receptor P2Y1 Homo sapiens 73-79 17155953-1 2007 BACKGROUND: Activation of two receptors for adenosine diphosphate (ADP), P2Y(1) and P2Y(12), is necessary for ADP-induced platelet aggregation (PA). Adenosine Diphosphate 67-70 purinergic receptor P2Y1 Homo sapiens 73-79 17155953-1 2007 BACKGROUND: Activation of two receptors for adenosine diphosphate (ADP), P2Y(1) and P2Y(12), is necessary for ADP-induced platelet aggregation (PA). Adenosine Diphosphate 110-113 purinergic receptor P2Y1 Homo sapiens 73-79 17365861-7 2007 When MPAR by ADP in the diabetic subjects was divided into two groups (high group: >50%, low group: <50%), the serum leptin concentration in the high group was significantly increased, compared with that in the low group. Adenosine Diphosphate 13-16 leptin Homo sapiens 123-129 17365861-8 2007 These results suggest that ADP-induced platelet aggregation may be associated with serum leptin concentration in diabetic subjects, and that leptin-associated platelet aggregation may affect the development of cardiovascular complications in obese and diabetic subjects. Adenosine Diphosphate 27-30 leptin Homo sapiens 89-95 17215444-1 2007 The metabotropic receptor P2Y1 is necessary for full ADP-induced platelet activation and is localized on various intrinsic renal cells, including mesangial cells, podocytes, and endothelial cells. Adenosine Diphosphate 53-56 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 26-30 17096705-2 2007 OBJECTIVE: Secreted adenosine 5"-diphosphate (ADP) potentiates GPVI-induced platelet aggregation at particular agonist concentrations. Adenosine Diphosphate 20-44 glycoprotein VI platelet Homo sapiens 63-67 17096705-2 2007 OBJECTIVE: Secreted adenosine 5"-diphosphate (ADP) potentiates GPVI-induced platelet aggregation at particular agonist concentrations. Adenosine Diphosphate 46-49 glycoprotein VI platelet Homo sapiens 63-67 17096705-9 2007 The effects of disruption of lipid rafts in in vitro assays can be attributed to inhibition of ADP feedback that potentiates GPVI signaling. Adenosine Diphosphate 95-98 glycoprotein VI platelet Homo sapiens 125-129 17159905-3 2007 The crystal structure of the catalytic core of human Upf1p determined in three states (phosphate-, AMPPNP- and ADP-bound forms) reveals an overall structure containing two RecA-like domains with two additional domains protruding from the N-terminal RecA-like domain. Adenosine Diphosphate 111-114 UPF1 RNA helicase and ATPase Homo sapiens 53-58 16857990-0 2006 G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases. Adenosine Diphosphate 64-67 Rous sarcoma oncogene Mus musculus 112-115 16857990-1 2006 ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 58-62 16857990-1 2006 ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 64-69 16857990-1 2006 ADP-induced TXA2 generation requires the costimulation of P2Y1, P2Y12, and the GPIIb/IIIa receptors. Adenosine Diphosphate 0-3 integrin alpha 2b Mus musculus 79-84 35247768-3 2022 Here we report the Cryo-EM structure of full-length human p97 dodecamer in 3.0 A resolution, the structure was captured in ADP-bound form but only D1 ATPase sites were well occupied by nucleotide and D2 sites are empty, furthermore, 12 non-ATP-competitive inhibitors of NMS-873 bound in the interface between each p97 monomer. Adenosine Diphosphate 123-126 melanotransferrin Homo sapiens 58-61 16857990-3 2006 In this study, we have investigated the role of G-protein-gated inwardly rectifying potassium channels (GIRKs), a recently identified functional effector for the P2Y12 receptor, in the regulation of ADP-induced TXA2 generation. Adenosine Diphosphate 199-202 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 162-167 35443035-7 2022 Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale (PANSS) item "lack of judgment and insight"; IL-1beta, IL-12 and TNF-alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Adenosine Diphosphate 18-21 interleukin 1 alpha Homo sapiens 153-161 17111306-0 2006 Increased prolactin in acute coronary syndromes as putative Co-activator of ADP-stimulated P-selectin expression. Adenosine Diphosphate 76-79 selectin P Homo sapiens 91-101 17111306-5 2006 However, patients with acute myocardial infarction as a subgroup of acute coronary syndromes showed the highest prolactin levels as well as ADP stimulated P-selectin expression. Adenosine Diphosphate 140-143 selectin P Homo sapiens 155-165 17111306-6 2006 In the myocardial infarction subgroup prolactin values showed a significant correlation to ADP stimulated P-selectin expression on platelets (r (2)=0.41; p=0.025), whereas leptin was not correlated. Adenosine Diphosphate 91-94 selectin P Homo sapiens 106-116 16817779-4 2006 HNP1 (human neutrophil protein 1) inhibited DT- or ETA-mediated ADP-ribosylation of eEF2 (eukaryotic elongation factor 2) and protected HeLa cells against DT- or ETA-induced cell death. Adenosine Diphosphate 64-67 eukaryotic translation elongation factor 2 Homo sapiens 84-88 35157000-0 2022 Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Adenosine Diphosphate 44-47 neuralized E3 ubiquitin protein ligase 4 Homo sapiens 0-25 16848759-1 2006 P2Y1 [P2 (purinergic type-2)-receptor 1] is a G-protein-coupled ADP receptor that regulates platelet activation and ADP-induced Ca2+ signalling. Adenosine Diphosphate 64-67 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 0-4 35157000-0 2022 Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Adenosine Diphosphate 44-47 neuralized E3 ubiquitin protein ligase 4 Homo sapiens 27-33 35157000-7 2022 Collectively, our studies reveal that NEURL4 acts as the main mitochondrial ART enzyme under physiological conditions and provide novel insights in the regulation of mitochondria homeostasis through ADP-ribosylation. Adenosine Diphosphate 199-202 neuralized E3 ubiquitin protein ligase 4 Homo sapiens 38-44 34860143-6 2022 MEASUREMENTS AND MAIN RESULTS: Aeroallergen-exposure induced the extracellular release of ADP and ATP, nucleotides that activate P2Y13-R. ATP, ADP, aeroallergen (house dust mite, cockroach or Alternaria) or virus exposure induced the nuclear-to-cytoplasmic translocation and subsequent release of IL-33 and HMGB1, and this response was ablated by genetic deletion or pharmacological antagonism of P2Y13. Adenosine Diphosphate 90-93 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 397-402 17060024-6 2006 In addition, the average mRNA expression of p56lck, p59fyn and zap-70 were all found to be dramatically higher in the mice immunized with only ADP/ATP carrier peptides than in the control-group. Adenosine Diphosphate 143-146 zeta-chain (TCR) associated protein kinase Mus musculus 63-69 35343271-8 2022 Addition of BMMC and ADP recovered the normal depolarization profile, suggesting that stabilization of the adenine nucleotide translocase (ANT) in a conformation that inhibits PTP opening offers a partial defense mechanism against IR injury. Adenosine Diphosphate 21-24 solute carrier family 25 member 6 Homo sapiens 107-137 35343271-8 2022 Addition of BMMC and ADP recovered the normal depolarization profile, suggesting that stabilization of the adenine nucleotide translocase (ANT) in a conformation that inhibits PTP opening offers a partial defense mechanism against IR injury. Adenosine Diphosphate 21-24 solute carrier family 25 member 6 Homo sapiens 139-142 16946495-6 2006 ALDP exhibited an affinity to both ADP and ATP. Adenosine Diphosphate 35-38 ATP binding cassette subfamily D member 1 Homo sapiens 0-4 16804093-5 2006 These results were paralleled in human platelets, in which PMA reduced subsequent ADP-induced P2Y1 and P2Y12 receptor signaling. Adenosine Diphosphate 82-85 purinergic receptor P2Y1 Homo sapiens 94-98 16804093-8 2006 ADP-induced P2Y1 receptor internalization is attenuated by PKC inhibitors, whereas that of the P2Y12 receptor is unaffected. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 12-25 16804879-5 2006 Kinetic analysis of the total pyruvate kinase activity indicated that this activity was greatly dependent on the presence of ADP and also showed a great affinity for PEP, with an estimated Km in supernatants of 0.15-0.20 mM. Adenosine Diphosphate 125-128 progestagen associated endometrial protein Homo sapiens 166-169 35392250-10 2022 We also found that ADP-altered complex II respiration in complex fashion probably involving decreased DeltaPsi due to ATP synthesis, a GDP-like nucleotide inhibition of UCP1, and allosteric enzyme action. Adenosine Diphosphate 19-22 uncoupling protein 1 Homo sapiens 169-173 16973501-8 2006 However, our results showed almost identical levels of peak calcium between wild-type or PAR-4 null mice when stimulated with either ADP or U46619. Adenosine Diphosphate 133-136 coagulation factor II (thrombin) receptor-like 3 Mus musculus 89-94 2804056-1 1989 Intravenous injection of ADP into rats produced a rapid increase of plasma phospholipase A2 activity with a concomitant decrease in platelet count. Adenosine Diphosphate 25-28 phospholipase A2 group IB Rattus norvegicus 75-91 17066149-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y1 and P2Y12) plays a very important role in thrombogenesis. Adenosine Diphosphate 19-43 purinergic receptor P2Y1 Homo sapiens 79-83 2804056-4 1989 These findings, together with the fact that ADP is a stimulant specific for platelets, suggest that the phospholipase A2 observed may be released into plasma from activated platelets in vivo. Adenosine Diphosphate 44-47 phospholipase A2 group IB Rattus norvegicus 104-120 17066149-1 2006 The interaction of adenosine-5"-diphosphate (ADP) with its platelet receptors (P2Y1 and P2Y12) plays a very important role in thrombogenesis. Adenosine Diphosphate 45-48 purinergic receptor P2Y1 Homo sapiens 79-83 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 223-226 protein kinase C epsilon Homo sapiens 74-85 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 383-386 protein kinase C epsilon Homo sapiens 74-85 2813362-11 1989 Since pyruvate kinase is a key enzyme in regulating cellular ADP, ATP, and pyruvate, our findings suggest that p58 may be involved in mediating some of the cellular metabolic effects induced by thyroid hormones. Adenosine Diphosphate 61-64 pyruvate kinase M1/2 Homo sapiens 111-114 2547780-13 1989 In broken Balb/c3T3 cell membranes, 10 nM IGF-II rapidly attenuated the IAP-catalyzed ADP-ribosylation of a 40-kDa protein in a manner requiring magnesium ion. Adenosine Diphosphate 86-89 insulin-like growth factor 2 Mus musculus 42-48 2542409-8 1989 PT induced the ADP-ribosylation of a 46-kDa substrate in membrane preparations from IL-1-responsive cells. Adenosine Diphosphate 15-18 interleukin 1 alpha Homo sapiens 84-88 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 383-386 protein kinase C epsilon Homo sapiens 74-85 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 383-386 protein kinase C epsilon Homo sapiens 74-85 16943556-4 2006 Stimulation of nAChR induced activation of PKC-epsilon, and inhibition of PKC-epsilon by expression of the dominant-negative mutant of PKC-epsilon (DN-PKC-epsilon) or short interfering (siRNA) against PKC-epsilon abolished ADP via decreasing the frequency and quantal size of fused vesicles without affecting basal exocytosis, suggesting that PKC-epsilon is specifically involved in ADP. Adenosine Diphosphate 383-386 protein kinase C epsilon Homo sapiens 74-85 2497737-5 1989 GL alpha was [32P]ADP-ribosylated in the presence of pertussis toxin and [32P]NAD+. Adenosine Diphosphate 18-21 GLA Bos taurus 0-8 16943556-5 2006 Electron microscopy revealed that inhibition of PKC-epsilon disrupts activity-induced vesicle translocation required for ADP. Adenosine Diphosphate 121-124 protein kinase C epsilon Homo sapiens 48-59 2497737-6 1989 Analysis of [32P]ADP-ribosylated alpha subunits by SDS/polyacrylamide-gel electrophoresis and isoelectric focusing showed that GL alpha was distinct from Gi alpha and Go alpha, but very similar to the predominant G-protein in neutrophil membranes. Adenosine Diphosphate 17-20 GLA Bos taurus 127-135 16943556-6 2006 We also suggest the involvement of myristoylated alanine-rich C kinase substrate (MARCKS), which is known as a downstream target of PKC-epsilon, in ADP of LDCV exocytosis. Adenosine Diphosphate 148-151 protein kinase C epsilon Homo sapiens 132-143 16943556-7 2006 The level of phospho-MARCKS correlated with the time course of ADP and was reduced by transfection with DN-PKC-epsilon. Adenosine Diphosphate 63-66 protein kinase C epsilon Homo sapiens 104-118 16943556-10 2006 Together, we provide evidence that ADP of LDCV exocytosis is regulated by PKC-epsilon and its downstream target MARCKS via modulating vesicle translocation. Adenosine Diphosphate 35-38 protein kinase C epsilon Homo sapiens 74-85 2539213-2 1989 Low amounts of the radiolabeled anti-Fg Fab bound to unstimulated or adenosine diphosphate (ADP)-stimulated cells. Adenosine Diphosphate 69-90 FA complementation group B Homo sapiens 40-43 2539213-2 1989 Low amounts of the radiolabeled anti-Fg Fab bound to unstimulated or adenosine diphosphate (ADP)-stimulated cells. Adenosine Diphosphate 92-95 FA complementation group B Homo sapiens 40-43 17015265-0 2006 The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Adenosine Diphosphate 4-7 mitogen-activated protein kinase 8 Rattus norvegicus 58-61 2521786-3 1989 The binding of PFK to actin is inhibited by ATP and ADP but not by fructose 6-phosphate or fructose 2,6-bisphosphate. Adenosine Diphosphate 52-55 actin Oryctolagus cuniculus 22-27 16546137-1 2006 ATP-stimulated P2X1 and ADP-stimulated P2Y1 receptors play important roles in platelet activation. Adenosine Diphosphate 24-27 purinergic receptor P2Y1 Homo sapiens 39-43 2783040-4 1989 The aggregation was dose-dependent and inhibited by pretreatment with a specific PAF antagonist, ONO 6240, but not by indomethacin or creatine phosphate/creatine phosphokinase, which inhibit the platelet aggregation due to arachidonic acid or ADP, respectively. Adenosine Diphosphate 243-246 PCNA clamp associated factor Homo sapiens 81-84 16643434-5 2006 High glucose levels enhanced adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-induced platelet P-selectin expression, and TRAP-induced platelet fibrinogen binding. Adenosine Diphosphate 29-50 selectin P Homo sapiens 123-133 2518355-4 1989 These ligand-mediated alterations of cholera and pertussis toxin-catalysed ADP ribosylation demonstrate that, in this system, the growth factor receptor interacts functionally with Gi2. Adenosine Diphosphate 75-78 myotrophin Rattus norvegicus 130-143 16643434-5 2006 High glucose levels enhanced adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-induced platelet P-selectin expression, and TRAP-induced platelet fibrinogen binding. Adenosine Diphosphate 52-55 selectin P Homo sapiens 123-133 16652167-7 2006 These data indicate that P2Y(6), P2Y(12), P2Y(13) and P2X receptors mediate much of the rapid calcium responses and shape changes in microglia to low concentrations of ATP, presumably at least partly because ATP is rapidly hydrolyzed to ADP. Adenosine Diphosphate 237-240 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mus musculus 25-31 2575830-4 1989 In mammary arteries, acetylcholine, thrombin, adenosine diphosphate, histamine and the calcium ionophore A23187 evoked endothelium-dependent relaxations blocked by hemoglobin or methylene blue, but not by cyclooxygenase inhibitors delineating EDRF as the mediator; in vascular smooth muscle cells, this was associated with a rise in intracellular cyclic GMP. Adenosine Diphosphate 46-67 alpha hemoglobin stabilizing protein Homo sapiens 243-247 16652167-7 2006 These data indicate that P2Y(6), P2Y(12), P2Y(13) and P2X receptors mediate much of the rapid calcium responses and shape changes in microglia to low concentrations of ATP, presumably at least partly because ATP is rapidly hydrolyzed to ADP. Adenosine Diphosphate 237-240 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 33-40 16652167-7 2006 These data indicate that P2Y(6), P2Y(12), P2Y(13) and P2X receptors mediate much of the rapid calcium responses and shape changes in microglia to low concentrations of ATP, presumably at least partly because ATP is rapidly hydrolyzed to ADP. Adenosine Diphosphate 237-240 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 42-49 16600868-3 2006 Here we show that both subunits can simultaneously bind ATP and identify the Msh6 subunit as containing the high-affinity ATP binding site and Msh2 as containing a high-affinity ADP binding site. Adenosine Diphosphate 178-181 mutS homolog 6 Homo sapiens 77-81 3183958-1 1988 SDZ 64-412 is a trimethoxyphenylethylphenyl imidazo[2,1-a] isoquinoline molecule that displays marked in vitro inhibition of platelet activating factor (PAF)-induced human platelet aggregation (IC50 = 60 nM) but is without inhibition (at 100 microM) of epinephrine-, ADP- or collagen-induced aggregation. Adenosine Diphosphate 267-270 PCNA clamp associated factor Homo sapiens 153-156 16600868-4 2006 Stable binding of ATP to Msh6 causes decreased affinity of Msh2 for ADP, and binding to mispaired DNA stabilized the binding of ATP to Msh6. Adenosine Diphosphate 68-71 mutS homolog 6 Homo sapiens 25-29 3054120-1 1988 The folded 10 S monomer conformation of smooth muscle myosin traps the hydrolysis products ADP and Pi in its active sites. Adenosine Diphosphate 91-94 myosin heavy chain 14 Homo sapiens 54-60 16600868-4 2006 Stable binding of ATP to Msh6 causes decreased affinity of Msh2 for ADP, and binding to mispaired DNA stabilized the binding of ATP to Msh6. Adenosine Diphosphate 68-71 mutS homolog 6 Homo sapiens 135-139 2973154-4 1988 Whereas C17 inhibited the binding of fibrinogen to platelets and platelet aggregation induced by adenosine diphosphate (ADP) or collagen, 6C9 caused irreversible aggregation of platelets, both in the presence and absence of extracellular fibrinogen. Adenosine Diphosphate 97-118 cytokine like 1 Homo sapiens 8-11 2973154-4 1988 Whereas C17 inhibited the binding of fibrinogen to platelets and platelet aggregation induced by adenosine diphosphate (ADP) or collagen, 6C9 caused irreversible aggregation of platelets, both in the presence and absence of extracellular fibrinogen. Adenosine Diphosphate 120-123 cytokine like 1 Homo sapiens 8-11 16634757-1 2006 Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-21 purinergic receptor P2Y1 Homo sapiens 142-155 16634757-1 2006 Adenosine diphosphate (ADP) initiates and maintains sustained aggregation of platelets through simultaneous activation of both the Gq-coupled P2Y1 receptor and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 142-155 16415908-1 2006 Based on pharmacological criteria, we previously suggested that in the mouse aorta, endothelium-dependent relaxation by nucleotides is mediated by P2Y1 (adenosine diphosphate (ADP)), P2Y2 (adenosine triphosphate (ATP)) and P2Y6 (uridine diphosphate (UDP)) receptors. Adenosine Diphosphate 153-174 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 147-151 2840260-3 1988 Treatment of the cells with the islet-activating protein (IAP) pertussis toxin, which ADP-ribosylated a 41,000 mol wt membrane protein, effectively suppressed the phosphoinositide response to ATP in addition to ATP-dependent I- efflux at agonist concentrations below 10 microM. Adenosine Diphosphate 86-89 magnesium transporter 1 Rattus norvegicus 32-56 2840260-3 1988 Treatment of the cells with the islet-activating protein (IAP) pertussis toxin, which ADP-ribosylated a 41,000 mol wt membrane protein, effectively suppressed the phosphoinositide response to ATP in addition to ATP-dependent I- efflux at agonist concentrations below 10 microM. Adenosine Diphosphate 86-89 magnesium transporter 1 Rattus norvegicus 58-61 16328495-4 2006 Transcripts for the P2Y(1) and P2Y(6) isoforms have also been detected in taste tissue preparations, this observation being consistent with the ADP and UDP responsiveness of taste cells. Adenosine Diphosphate 144-147 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 20-26 2840260-6 1988 However, the responses to ATP, its nonhydrolyzable derivatives, or ADP at the higher agonist concentrations, especially above 100 microM, were only partially inhibited by IAP, even though the IAP substrate was totally ADP ribosylated by the toxin. Adenosine Diphosphate 67-70 magnesium transporter 1 Rattus norvegicus 171-174 2838335-0 1988 The binary complex of pig plasma gelsolin with Mg2+-G-actin in ATP and ADP. Adenosine Diphosphate 71-74 GSN Sus scrofa 33-41 16328495-4 2006 Transcripts for the P2Y(1) and P2Y(6) isoforms have also been detected in taste tissue preparations, this observation being consistent with the ADP and UDP responsiveness of taste cells. Adenosine Diphosphate 144-147 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mus musculus 31-37 16507998-3 2006 Here we show that tumor necrosis factor alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport of ADP into mitochondria, which resulted in reduced ATP and necrotic cell death. Adenosine Diphosphate 142-145 receptor interacting serine/threonine kinase 1 Homo sapiens 54-57 2835990-8 1988 Furthermore, the findings that increased intracellular cAMP inhibits PMA- or OAG-induced p47 phosphorylation in excess of that due solely to CP/CPK, and that cAMP significantly potentiates the effects of ADP removal and inhibition of cyclooxygenase in blocking p47 phosphorylation suggest that cAMP also exerts non-ADP-mediated inhibitory effects on PKC in intact platelets. Adenosine Diphosphate 204-207 pleckstrin Homo sapiens 261-264 2835990-8 1988 Furthermore, the findings that increased intracellular cAMP inhibits PMA- or OAG-induced p47 phosphorylation in excess of that due solely to CP/CPK, and that cAMP significantly potentiates the effects of ADP removal and inhibition of cyclooxygenase in blocking p47 phosphorylation suggest that cAMP also exerts non-ADP-mediated inhibitory effects on PKC in intact platelets. Adenosine Diphosphate 315-318 pleckstrin Homo sapiens 89-92 16507998-3 2006 Here we show that tumor necrosis factor alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport of ADP into mitochondria, which resulted in reduced ATP and necrotic cell death. Adenosine Diphosphate 142-145 solute carrier family 25 member 6 Homo sapiens 82-112 16507998-3 2006 Here we show that tumor necrosis factor alpha induced RIP-dependent inhibition of adenine nucleotide translocase (ANT)-conducted transport of ADP into mitochondria, which resulted in reduced ATP and necrotic cell death. Adenosine Diphosphate 142-145 solute carrier family 25 member 6 Homo sapiens 114-117 16507998-4 2006 The inhibition of ADP/ATP exchange coincided with the loss of interaction between ANT and cyclophilin D and the inability of ANT to adopt the cytosolic conformational state, which prevented cytochrome c release. Adenosine Diphosphate 18-21 solute carrier family 25 member 6 Homo sapiens 82-85 16253220-7 2005 In the control group, CD62-P, antifibrinogen and annexin-V levels increased significantly after ADP activation (P<0.05, P<0.05, P<0.01, respectively). Adenosine Diphosphate 96-99 selectin P Homo sapiens 22-28 3408729-1 1988 Rabbit skeletal muscle G-actin has been treated to obtain ADP, 1,N6-ethenoadenosine diphosphate (epsilon-ADP), or 1,N6-ethenoadenosine triphosphate (epsilon-ATP) at the nucleotide binding site and either Mg2+ or Ca2+ at high- and moderate-affinity metal binding sites. Adenosine Diphosphate 58-61 actin Oryctolagus cuniculus 25-30 3408729-2 1988 Apparent rates or rate constants for the displacement of the actin-bound nucleotides by epsilon-ATP or ATP have been obtained by stopped-flow measurements at pH 8 and 20 degrees C of the fluorescence difference between bound and free epsilon-ATP or epsilon-ADP. Adenosine Diphosphate 257-260 actin Oryctolagus cuniculus 61-66 3408729-4 1988 At high levels of Mg2+ (greater than 50 microM), low ADP concentrations displace epsilon-ATP from G-actin as a consequence of Mg2+ binding to moderate-affinity sites on the actin. Adenosine Diphosphate 53-56 actin Oryctolagus cuniculus 100-105 3408729-4 1988 At high levels of Mg2+ (greater than 50 microM), low ADP concentrations displace epsilon-ATP from G-actin as a consequence of Mg2+ binding to moderate-affinity sites on the actin. Adenosine Diphosphate 53-56 actin Oryctolagus cuniculus 173-178 3408729-7 1988 A mechanism for the displacement reaction is proposed in which there are two forms of an actin-ADP complex and metal binding influences the ratio of these forms as well as the binding of ATP. Adenosine Diphosphate 95-98 actin Oryctolagus cuniculus 89-94 2827786-9 1988 Binding of GPRP-fibrin (soluble fibrin oligomers formed in the presence of 1 mM Gly-Pro-Arg-Pro) to ADP-stimulated platelets was also inhibited by a monoclonal antibody directed against the GPIIb-IIIa complex. Adenosine Diphosphate 100-103 glutathione peroxidase 2 Homo sapiens 11-15 16253220-7 2005 In the control group, CD62-P, antifibrinogen and annexin-V levels increased significantly after ADP activation (P<0.05, P<0.05, P<0.01, respectively). Adenosine Diphosphate 96-99 annexin A5 Homo sapiens 49-58 2963184-4 1988 Anti-platelet-activating factor completely blocked the aggregation of rabbit platelets induced by PAF, ADP or arachidonic acid. Adenosine Diphosphate 103-106 PCNA clamp associated factor Homo sapiens 5-31 3691813-5 1987 In UCP this C-terminal stretch represents a structural difference to the similarly folded ADP/ATP carrier which does not form a corresponding cleavage product. Adenosine Diphosphate 90-93 uncoupling protein 1 Homo sapiens 3-6 16307999-6 2005 Basal and lipopolysaccharide-stimulated monocyte tissue factor expression, as well as basal and adenosine diphosphate-stimulated platelet tissue factor expression, did not show significant variations over time and were similar in the on-pump and off-pump coronary artery bypass grafting groups throughout the course of the study. Adenosine Diphosphate 96-117 coagulation factor III, tissue factor Homo sapiens 138-151 2824697-6 1987 In contrast, NEM pretreatment inhibited islet activating protein (IAP)-catalyzed ADP ribosylation of membrane-bound (41,000-dalton) and purified (39,000/41,000-dalton) GTP-binding proteins. Adenosine Diphosphate 81-84 magnesium transporter 1 Rattus norvegicus 66-69 2824697-8 1987 One is a highly sensitive site to NEM (a concentration range of 1-50 microM), which is probably a cysteine residue, IAP-catalyzed ADP-ribosylating site on the alpha-subunit of GTP-binding protein. Adenosine Diphosphate 130-133 magnesium transporter 1 Rattus norvegicus 116-119 3667696-5 1987 When platelets were stimulated with ADP 10-20 s after addition of PR to a final pH of 6 (PR6), both myosin light chain (MLC) phosphorylation and myosin and actin association with the cytoskeleton were reduced in correlation with the inhibition of shape change. Adenosine Diphosphate 36-39 myosin heavy chain 14 Homo sapiens 100-106 3667696-6 1987 But when ADP was added 30 s after PR6, the MLC phosphorylation was essentially the same in PR or in chloride, although shape change and myosin and actin association with the cytoskeleton remained inhibited. Adenosine Diphosphate 9-12 myosin heavy chain 14 Homo sapiens 136-142 16307999-7 2005 Platelet expression of P-selectin, both basal and after adenosine diphosphate stimulation, did not significantly change over time and was not different in the on-pump and off-pump coronary artery bypass grafting groups. Adenosine Diphosphate 56-77 selectin P Homo sapiens 23-33 15919094-7 2005 The electrical meaning of the hydrolysis reaction is to reduce the dipole moment p(0)-the remaining dipole moment of the adenosine diphosphate (ADP) is appropriately smaller to return the low negative value of the electric energy nearly back to its initial value, enabling the removal of ADP from the myosin head so that the cycling process can be repeated. Adenosine Diphosphate 121-142 myosin heavy chain 14 Homo sapiens 301-307 3117105-8 1987 Go alpha in the presence of G beta gamma is a substrate for pertussis toxin catalyzed ADP-ribosylation; the modification was inhibited by photolyzed rhodopsin and enhanced by guanosine 5"-O-(2-thiodiphosphate). Adenosine Diphosphate 86-89 rhodopsin Bos taurus 149-158 3591957-6 1987 Expression of the c-myc protooncogene was not detected in unstimulated cells, but accumulated maximally after 1 h of exposure to ADP. Adenosine Diphosphate 129-132 MYC proto-oncogene, bHLH transcription factor Homo sapiens 18-23 15919094-7 2005 The electrical meaning of the hydrolysis reaction is to reduce the dipole moment p(0)-the remaining dipole moment of the adenosine diphosphate (ADP) is appropriately smaller to return the low negative value of the electric energy nearly back to its initial value, enabling the removal of ADP from the myosin head so that the cycling process can be repeated. Adenosine Diphosphate 144-147 myosin heavy chain 14 Homo sapiens 301-307 15919094-7 2005 The electrical meaning of the hydrolysis reaction is to reduce the dipole moment p(0)-the remaining dipole moment of the adenosine diphosphate (ADP) is appropriately smaller to return the low negative value of the electric energy nearly back to its initial value, enabling the removal of ADP from the myosin head so that the cycling process can be repeated. Adenosine Diphosphate 288-291 myosin heavy chain 14 Homo sapiens 301-307 3587377-1 1987 The triazolodiazepines brotizolam, triazolam and alprazolam inhibited PAF-induced human platelet aggregation in vitro (IC50 = 0.54, 7.6 and 13.7 microM, respectively) but showed only a weak or no effect against other aggregating agents (ADP, adrenaline, collagen, serotonin, arachidonic acid). Adenosine Diphosphate 237-240 PCNA clamp associated factor Homo sapiens 70-73 16216083-0 2005 ATP- and ADP-dependent modulation of RNA unwinding and strand annealing activities by the DEAD-box protein DED1. Adenosine Diphosphate 9-12 DEAD-box ATP-dependent RNA helicase DED1 Saccharomyces cerevisiae S288C 107-111 3569302-2 1987 The toxin-induced rounding up of CEC is correlated with ADP-ribosylation of actin in intact cells in a time and concentration-dependent manner. Adenosine Diphosphate 56-59 actin, beta Gallus gallus 76-81 3569302-7 1987 It is suggested that in intact CEC botulinum C2 toxin causes ADP-ribosylation of G-actin but not of F-actin thereby leading to an accumulation in the pool of monomeric actin. Adenosine Diphosphate 61-64 actin, beta Gallus gallus 83-88 16216083-3 2005 We further demonstrate that DED1 establishes an ATP-dependent steady state between unwinding and annealing, which enables the enzyme to modulate the balance between the two opposing activities through ATP and ADP concentrations. Adenosine Diphosphate 209-212 DEAD-box ATP-dependent RNA helicase DED1 Saccharomyces cerevisiae S288C 28-32 16216083-5 2005 Collectively, these findings expand the known functional repertoire of DEAD-box proteins and reveal the capacity of DED1 to remodel RNA in response to ADP and ATP concentrations by facilitating not only disruption but also formation of RNA duplexes. Adenosine Diphosphate 151-154 DEAD-box ATP-dependent RNA helicase DED1 Saccharomyces cerevisiae S288C 116-120 16341775-1 2005 The three adenine nucleotide translocator (ANT1 to ANT3) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. Adenosine Diphosphate 164-167 solute carrier family 25 member 4 Homo sapiens 43-47 3553173-5 1987 The homologous portion of the amino acid sequence in dihydrofolate reductases, which corresponds to the portion coded by exon 3 of mammalian dihydrofolate reductase genes, provided a binding site of the adenosine diphosphate moiety of NADPH in the crystal structure of dihydrofolate reductase. Adenosine Diphosphate 203-224 dihydrofolate reductase Homo sapiens 53-76 3553173-5 1987 The homologous portion of the amino acid sequence in dihydrofolate reductases, which corresponds to the portion coded by exon 3 of mammalian dihydrofolate reductase genes, provided a binding site of the adenosine diphosphate moiety of NADPH in the crystal structure of dihydrofolate reductase. Adenosine Diphosphate 203-224 dihydrofolate reductase Homo sapiens 141-164 16341775-1 2005 The three adenine nucleotide translocator (ANT1 to ANT3) isoforms, differentially expressed in human cells, play a crucial role in cell bioenergetics by catalyzing ADP and ATP exchange across the mitochondrial inner membrane. Adenosine Diphosphate 164-167 solute carrier family 25 member 6 Homo sapiens 51-55 3019775-2 1986 ADP-stimulated mobilization of internal Ca2+ and phosphorylation of myosin were enhanced in the presence of extracellular Ca2+ but the increase in IP3 was not significantly affected by external Ca2+. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 68-74 16174728-4 2005 Here, we show that the phosphate analogue AlF4 can form two ADP.phosphate analog states, one with weak binding of myosin to actin and the other with strong binding of myosin to actin. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 114-120 3780673-0 1986 ATP-linked monomer-polymer equilibrium of smooth muscle myosin: the free folded monomer traps ADP.Pi. Adenosine Diphosphate 94-97 myosin heavy chain 14 Homo sapiens 56-62 3780673-4 1986 Following dissolution, the hydrolysis products ADP.Pi are retained on the heads of the folded myosin monomers, and are released so slowly (half time approximately 100 min at 100 mM KCl) as to be effectively trapped. Adenosine Diphosphate 47-50 myosin heavy chain 14 Homo sapiens 94-100 2943735-3 1986 At equal concentrations of protein, factor A and the 7 S particle catalyze the hydrolysis of ATP to ADP and Pi at similar rates. Adenosine Diphosphate 100-103 general transcription factor 3A L homeolog Xenopus laevis 36-44 16174728-4 2005 Here, we show that the phosphate analogue AlF4 can form two ADP.phosphate analog states, one with weak binding of myosin to actin and the other with strong binding of myosin to actin. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 167-173 15914557-8 2005 Thus, direct stimulation of P2Y(1) and P2Y(12) receptors, together with autocrine P2X(1) activation, is responsible for the activation of nonselective cation currents by the platelet agonist ADP. Adenosine Diphosphate 191-194 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 28-34 3743572-5 1986 Radiolabelled Fab fragments did not interact with non-stimulated platelets but significant binding was observed when the cells were stimulated by ADP, thrombin, collagen and Ca ionophore A23187. Adenosine Diphosphate 146-149 FA complementation group B Homo sapiens 14-17 3743572-8 1986 At the following concentrations of stimuli: 30 microM ADP, 4 micrograms/ml collagen, 3 microM A23187 and 0.05 U/ml thrombin, the immune Fab fragments inhibited platelet aggregation. Adenosine Diphosphate 54-57 FA complementation group B Homo sapiens 136-139 15659712-4 2005 We found that AK1(-/-) muscle exhibited a diminished inosine 5"-monophosphate formation rate (14% of WT) and an inordinate accumulation of ADP ( approximately 1.5 mM) at the highest energy demands, compared with WT controls. Adenosine Diphosphate 139-142 adenylate kinase 1 Mus musculus 14-17 2944489-3 1986 By the same token Cd2+ inhibits the ADP and ATP exchange-reaction and also inhibits succinate oxidation. Adenosine Diphosphate 36-39 CD2 molecule Homo sapiens 18-21 15955470-5 2005 While the platelet count was similar in both groups, platelet sensitivity to stimulators was reduced in group 1 (P-selectin and activated GP IIb/IIIa on ADP-stimulated platelets, p < or = 0.01). Adenosine Diphosphate 153-156 selectin P Homo sapiens 113-123 2934740-0 1986 Electron microscopic visualization of the ATPase site of myosin by photoaffinity labeling with a biotinylated photoreactive ADP analog. Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 57-63 15968398-3 2005 In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets. Adenosine Diphosphate 262-283 serpin family C member 1 Homo sapiens 63-75 2992964-2 1985 In the presence of Cd2+ selectivity to ADP[alpha S] and to ATP[beta S] isomers is reversed; in the presence of Co2+, selectivity is lost. Adenosine Diphosphate 39-42 CD2 molecule Homo sapiens 19-22 15968398-3 2005 In this study, we report that platelets express syndecan-4, an antithrombin-binding cell surface heparan sulphate proteoglycan, whose ligation with antithrombin inhibits activated platelet-dependent superoxide anion release from neutrophils by the limitation of adenosine diphosphate and adenosine triphosphate secretion in activated platelets. Adenosine Diphosphate 262-283 serpin family C member 1 Homo sapiens 148-160 15968398-5 2005 We further observed that antithrombin limits CD40 ligand expression in adenosine diphosphate-activated platelets and inhibits the shedding of syndecan-4 from activated platelets. Adenosine Diphosphate 71-92 serpin family C member 1 Homo sapiens 25-37 15968398-7 2005 We suggest that antithrombin might exert beneficial effects in disseminated intravascular coagulation by reducing platelet activation, observed as inhibited CD40 ligand expression, syndecan-4 shedding, and adenosine diphosphate- and adenosine triphosphate-release from activated platelets with subsequent inhibition of neutrophil respiratory burst. Adenosine Diphosphate 206-227 serpin family C member 1 Homo sapiens 16-28 2981686-5 1985 Furthermore we have observed hyper ADP-ribosylation of histone H2B at NAD concentrations of 10 microM suggesting that histone H2B can undergo the same type of ADP-ribosylation pattern as histone H1. Adenosine Diphosphate 35-38 H2B clustered histone 21 Homo sapiens 63-66 2981686-5 1985 Furthermore we have observed hyper ADP-ribosylation of histone H2B at NAD concentrations of 10 microM suggesting that histone H2B can undergo the same type of ADP-ribosylation pattern as histone H1. Adenosine Diphosphate 35-38 H2B clustered histone 21 Homo sapiens 126-129 15968399-3 2005 The function of the two receptors for ADP, P2Y(1) and P2Y(12), is well-established in aggregation, but is incompletely understood in the platelet procoagulant response. Adenosine Diphosphate 38-41 purinergic receptor P2Y1 Homo sapiens 43-49 15790498-2 2005 Binding of its C-terminal region to glycosphingolipid Gb3 and Gb4 receptors on cell membrane is necessary for incorporation into cells, while the N-terminal polypeptide catalyzes transfer of the ADP-ribose moiety of NAD at N2 of dG in DNA. Adenosine Diphosphate 195-198 alpha 1,4-galactosyltransferase (P blood group) Homo sapiens 54-57 6240225-1 1984 The K+-EDTA-activated ATPase activity of chymotryptic myosin subfragment-1 (S-1) decreased by 85-90% when S-1 was incubated over a 2-h period at 35 degrees C. Addition of F-actin, ATP, or ATP analogs, such as ADP or PPi, to S-1 before incubation at 35 degrees C prevented the loss of ATPase activity. Adenosine Diphosphate 209-212 myosin heavy chain 14 Homo sapiens 54-60 6334536-1 1984 Stability constants for the Mg2+ and Cd2+ complexes of ATP, ADP, ATP alpha S, ATP beta S, and ADP alpha S have been determined at 30 degrees C and mu = 0.1 M by 31P NMR. Adenosine Diphosphate 60-63 CD2 molecule Homo sapiens 37-40 6334536-1 1984 Stability constants for the Mg2+ and Cd2+ complexes of ATP, ADP, ATP alpha S, ATP beta S, and ADP alpha S have been determined at 30 degrees C and mu = 0.1 M by 31P NMR. Adenosine Diphosphate 94-97 CD2 molecule Homo sapiens 37-40 15665114-0 2005 P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms. Adenosine Diphosphate 29-32 purinergic receptor P2Y1 Homo sapiens 0-4 15665114-1 2005 Adenosine 5"-diphosphate (ADP) plays a central role in regulating platelet function by the activation of the G protein-coupled receptors P2Y(1) and P2Y(12). Adenosine Diphosphate 0-24 purinergic receptor P2Y1 Homo sapiens 137-143 15665114-1 2005 Adenosine 5"-diphosphate (ADP) plays a central role in regulating platelet function by the activation of the G protein-coupled receptors P2Y(1) and P2Y(12). Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 137-143 6548525-3 1984 The avidin-myosin complex was readily formed in the presence of MgADP or MgATP. Adenosine Diphosphate 64-69 myosin heavy chain 14 Homo sapiens 11-17 15665114-8 2005 This study is the first to show that both P2Y(1) and P2Y(12) desensitize in human platelets, and it reveals ways in which their sensitivity to ADP may be differentially and independently altered. Adenosine Diphosphate 143-146 purinergic receptor P2Y1 Homo sapiens 42-48 15869601-3 2005 We sought to determine the importance of lipid rafts in ADP-mediated platelet activation via the G protein-coupled P2Y1 and P2Y12 receptors using lipid raft disruption by cholesterol depletion with methyl-beta-cyclodextrin. Adenosine Diphosphate 56-59 purinergic receptor P2Y1 Homo sapiens 115-119 15869602-4 2005 Leptin potentiated the aggregation of human platelets induced by low concentrations of ADP, collagen and epinephrine. Adenosine Diphosphate 87-90 leptin Homo sapiens 0-6 15671027-2 2005 The chaperone activity of Hsp90 requires ATP, which binds with approximately 10-fold lower affinity than ADP. Adenosine Diphosphate 105-108 heat shock protein 90 alpha family class A member 1 Homo sapiens 26-31 16052302-2 2005 CD39 (E-NTPDase1), is the endothelial ecto-ADPase inhibiting platelet function via hydrolysis of released platelet ADP. Adenosine Diphosphate 43-46 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 15361073-1 2005 The extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 skeletal muscle cells. Adenosine Diphosphate 47-50 integrin alpha 7 Mus musculus 28-43 15960075-5 2005 ADP-induced increases in PAC-1 binding were significantly enhanced by exposing the platelets to concentrations of either 20% or 40% HbV, whereas the ADP-induced increases in CD62P expression were not affected by HbV treatment at either concentration. Adenosine Diphosphate 149-152 selectin P Homo sapiens 174-179 15381153-11 2005 The results thus provide evidence that endogenous ADP-ribosylation of eEF2 can also take place by the binding of free ADP-ribose. Adenosine Diphosphate 50-53 eukaryotic translation elongation factor 2 Homo sapiens 70-74 15381153-11 2005 The results thus provide evidence that endogenous ADP-ribosylation of eEF2 can also take place by the binding of free ADP-ribose. Adenosine Diphosphate 118-121 eukaryotic translation elongation factor 2 Homo sapiens 70-74 15381153-12 2005 This nonenzymic reaction appears to account primarily for in vivo ADP-ribosylation of eEF2 under oxidative stress. Adenosine Diphosphate 66-69 eukaryotic translation elongation factor 2 Homo sapiens 86-90 15578726-5 2005 The GLUD2-derived GDH shows low basal activity and has the capacity to be activated fully by ADP or L-leucine. Adenosine Diphosphate 93-96 glutamate dehydrogenase 1 Homo sapiens 18-21 15578726-8 2005 Site-directed mutagenesis of GLUD1 gene showed that replacement of Gly456 by Ala made the enzyme resistant to GTP (IC(50) = 2.8 +/- 0.15 microM) without altering its regulation by ADP. Adenosine Diphosphate 180-183 glutamate dehydrogenase 1 Homo sapiens 29-34 15486956-2 2005 The cytoplasmic and intramitochondrial ATP/ADP ratios, partly controlled by the adenine nucleotide translocator (ANT), are drastically modified. Adenosine Diphosphate 43-46 solute carrier family 25 member 6 Homo sapiens 80-111 6746669-1 1984 When platelets were stimulated with ADP to cause shape change without aggregation or secretion, myosin 20,000-Da light chain phosphorylation was rapid and appeared to precede slightly the shape change response. Adenosine Diphosphate 36-39 myosin heavy chain 14 Homo sapiens 96-102 6746669-5 1984 The dose-response curve of myosin phosphorylation very closely paralleled that of shape change with a midpoint at 0.7 microM ADP. Adenosine Diphosphate 125-128 myosin heavy chain 14 Homo sapiens 27-33 6746669-6 1984 ATP, a competitive antagonist of ADP, inhibited both shape change and myosin phosphorylation with the same concentration of ATP causing 50% inhibition of each response. Adenosine Diphosphate 33-36 myosin heavy chain 14 Homo sapiens 70-76 6238021-1 1984 The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem. Adenosine Diphosphate 116-119 myosin heavy chain 14 Homo sapiens 23-29 6238021-1 1984 The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem. Adenosine Diphosphate 116-119 myosin heavy chain 14 Homo sapiens 197-203 6238021-1 1984 The active site of the myosin subfragment-1 ATPase was affinity-labeled with ribose-modified fluorescent analogs of ADP, dADP, CDP, UDP, IDP, and GDP in combination with vanadate, forming a stable myosin-nucleoside diphosphate-vanadate complex that is analogous to the normal myosin-ADP-Pi intermediate [Hiratsuka, T. (1984) J. Biochem. Adenosine Diphosphate 116-119 myosin heavy chain 14 Homo sapiens 197-203 6739961-1 1984 CCl4 and ADP-Fe3+ determine an increased microsomal lipid peroxidation in liver tissue which is related to an impairment of the tubulin molecule in the case of CCl4 while no alteration is evident with ADP-Fe3+. Adenosine Diphosphate 9-12 C-C motif chemokine ligand 4 Homo sapiens 160-164 15486956-2 2005 The cytoplasmic and intramitochondrial ATP/ADP ratios, partly controlled by the adenine nucleotide translocator (ANT), are drastically modified. Adenosine Diphosphate 43-46 solute carrier family 25 member 6 Homo sapiens 113-116 15496502-3 2005 Coexpression of NTPDase1 with the P2Y(1) receptor resulted in increases in the EC(50) for 2"-methylthioadenosine 5"-diphosphate (2MeSADP; 12-fold), ADP (50-fold), and ATP (10-fold) for activation of phospholipase C. Similar effects were observed when the P2Y(1) receptor and NTPDase1 were expressed on different cells. Adenosine Diphosphate 133-136 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 16-24 6879510-0 1983 Influence of plasma fibronectin on the response to infusion of thrombin and adenosine diphosphate. Adenosine Diphosphate 76-97 fibronectin 1 Rattus norvegicus 20-31 6879510-3 1983 Mortality data indicated that rats with reduced fibronectin levels had reduced resistance to thrombin or adenosine diphosphate infusion. Adenosine Diphosphate 105-126 fibronectin 1 Rattus norvegicus 48-59 15496502-3 2005 Coexpression of NTPDase1 with the P2Y(1) receptor resulted in increases in the EC(50) for 2"-methylthioadenosine 5"-diphosphate (2MeSADP; 12-fold), ADP (50-fold), and ATP (10-fold) for activation of phospholipase C. Similar effects were observed when the P2Y(1) receptor and NTPDase1 were expressed on different cells. Adenosine Diphosphate 133-136 purinergic receptor P2Y1 Homo sapiens 34-49 15548728-0 2004 Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms. Adenosine Diphosphate 36-39 nitric oxide synthase 3, endothelial cell Mus musculus 41-45 6408754-4 1983 The specific effect of PAF, however, seems to be limited to induce reversible aggregation since second wave of aggregation and serotonin release were suppressed by a combination of acetylsalicylic acid and an ADP scavenging system. Adenosine Diphosphate 209-212 PCNA clamp associated factor Homo sapiens 23-26 6408754-6 1983 Subthreshold concentrations of PAF enhanced the platelet aggregation triggered by suboptimal concentrations of ADP, epinephrine, or collagen. Adenosine Diphosphate 111-114 PCNA clamp associated factor Homo sapiens 31-34 6408754-7 1983 Vice versa non-aggregating concentrations of ADP, epinephrine, collagen, Ca-ionophore A 23,187, or arachidonic acid amplified PAF-induced platelet aggregation. Adenosine Diphosphate 45-48 PCNA clamp associated factor Homo sapiens 126-129 15548728-0 2004 Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms. Adenosine Diphosphate 36-39 nitric oxide synthase 3, endothelial cell Mus musculus 60-64 15548728-5 2004 In eNOS-/- mice, responses to ADP were largely preserved, and a significant component of the response was resistant to L-NNA (a finding similar to that in WT mice treated with L-NNA). Adenosine Diphosphate 30-33 nitric oxide synthase 3, endothelial cell Mus musculus 3-7 6832146-0 1983 Interaction of ADP and magnesium with the active site of myosin subfragment-1 observed by reactivity changes of the critical thiols and by direct binding methods at low and high ionic strength. Adenosine Diphosphate 15-18 myosin heavy chain 14 Homo sapiens 57-63 6832146-1 1983 Comprehensive binding studies using direct and indirect methods yield stoichiometry and affinities for the binding of Mg X ADP and uncomplexed ADP to the active site of myosin subfragment-1. Adenosine Diphosphate 123-126 myosin heavy chain 14 Homo sapiens 169-175 15548728-6 2004 In the absence of L-NNA, responses to ADP were markedly reduced by charybdotoxin plus apamin [inhibitors of Ca2+-dependent K+ channels and responses mediated by endothelium-derived hyperpolarizing factor (EDHF)] in both WT and eNOS-/- mice. Adenosine Diphosphate 38-41 nitric oxide synthase 3, endothelial cell Mus musculus 227-231 15345752-0 2004 Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog. Adenosine Diphosphate 47-50 purinergic receptor P2Y1 Homo sapiens 61-74 15345752-1 2004 ADP is the cognate agonist of the P2Y1, P2Y12, and P2Y13 receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 34-38 15613030-6 2004 When secreted ADP was neutralized, activation of Rap2B induced by thrombin, but not by convulxin, was significantly reduced. Adenosine Diphosphate 14-17 RAP2B, member of RAS oncogene family Homo sapiens 49-54 15613030-7 2004 ADP itself was found to induce the rapid and sustained binding of GTP to Rap2B, and this effect was predominantly mediated by stimulation of the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-3 RAP2B, member of RAS oncogene family Homo sapiens 73-78 15284110-6 2004 Our results demonstrate that, under elevated shear stress conditions, ADP signaling through P2Y(1) may contribute to the initial stages of platelet adhesion and activation mediated by immobilized VWF, and through P2Y(12) to sustained thrombus formation. Adenosine Diphosphate 70-73 purinergic receptor P2Y1 Homo sapiens 92-98 15505213-0 2004 Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP. Adenosine Diphosphate 74-77 actin related protein 2 Homo sapiens 22-45 15505213-3 2004 Here we report crystal structures of Arp2/3 complex with bound ATP or ADP. Adenosine Diphosphate 70-73 actin related protein 2 Homo sapiens 37-41 15522469-2 2004 ADP (6 microM) and collagen (6 microg/mL) induced platelet aggregation, as well as ADP (2 microM) induced glycoprotein (GP) IIb/IIIa activation and P-selectin expression were assessed at baseline and 4, 24, and 48 h following clopidogrel front-loading. Adenosine Diphosphate 83-86 selectin P Homo sapiens 148-158 15717703-0 2004 Midazolam attenuates adenosine diphosphate-induced P-selectin expression and platelet-leucocyte aggregation. Adenosine Diphosphate 21-42 selectin P Homo sapiens 51-61 6858789-4 1983 The 23 subjects receiving aspirin showed a diminution of platelet aggregation induced by PAF due to inhibition of ADP release. Adenosine Diphosphate 114-117 PCNA clamp associated factor Homo sapiens 89-92 6824640-5 1983 U.S.A. 76, 4966] have shown it is possible to trap MgADP and other nucleotides stably at the active site of myosin by cross-linking two thiol groups. Adenosine Diphosphate 51-56 myosin heavy chain 14 Homo sapiens 108-114 6178541-0 1982 Beta-2-microglobulin-specific autoantibodies cause platelet aggregation and interfere with ADP-induced aggregation. Adenosine Diphosphate 91-94 beta-2-microglobulin Homo sapiens 0-20 6178541-1 1982 The anti-platelet activity of beta-2-microglobulin (beta 2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. Adenosine Diphosphate 166-169 beta-2-microglobulin Homo sapiens 30-50 6178541-1 1982 The anti-platelet activity of beta-2-microglobulin (beta 2m) specific autoantibodies isolated from sera of patients with autoimmune diseases was tested in direct and ADP-induced aggregation assays. Adenosine Diphosphate 166-169 beta-2-microglobulin Homo sapiens 52-59 6178541-3 1982 Anti-beta 2m autoantibodies also impaired ADP-induced platelet aggregation. Adenosine Diphosphate 42-45 beta-2-microglobulin Homo sapiens 5-12 7298614-0 1981 Temperature-modulated binding of ADP and adenyl-5"-yl imidodiphosphate to myosin subfragment 1 studied by calorimetric titration. Adenosine Diphosphate 33-36 myosin heavy chain 14 Homo sapiens 74-80 6267047-1 1981 Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2. Adenosine Diphosphate 26-29 eukaryotic translation elongation factor 2 Homo sapiens 61-80 6267047-2 1981 Diphtheria toxin inactivates protein synthesis elongation factor 2 by catalyzing the ADP-ribosylation of a novel derivative of histidine, diphthamide, in the protein (Van Ness, B. G., Howard, J. Adenosine Diphosphate 85-88 eukaryotic translation elongation factor 2 Homo sapiens 47-66 7032516-5 1981 The inactivation of hexokinase by Procion Green H-4G is competitively inhibited by the adenine nucleotides ATP and ADP and the sugar substrates D-glucose, D-mannose and D-fructose but not by nonsubstrates such as D-arabinose and D-galactose. Adenosine Diphosphate 115-118 hexokinase Saccharomyces cerevisiae S288C 20-30 6261809-4 1981 The purified enzyme hydrolyzes triphosphonucleosides (ATP, CTP, GTP, UTP) and diphosphonucleosides (ADP and to a lesser extent CDP, UDP, IDP) and presents pH optima of 6 for ATP and 7 for ADP. Adenosine Diphosphate 188-191 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 137-140 6776409-6 1980 One clear-cut difference between prokaryotes and eukaryotes is the diphtheria toxin reaction, which catalyses the covalent binding of adenosine diphosphate-ribose (ADPR) to the eukaryotic peptide elongation factor EF2 in contrast to the homologous prokaryotic factor EF-G. Adenosine Diphosphate 134-155 eukaryotic translation elongation factor 2 Homo sapiens 214-217 6776409-6 1980 One clear-cut difference between prokaryotes and eukaryotes is the diphtheria toxin reaction, which catalyses the covalent binding of adenosine diphosphate-ribose (ADPR) to the eukaryotic peptide elongation factor EF2 in contrast to the homologous prokaryotic factor EF-G. Adenosine Diphosphate 134-155 G elongation factor mitochondrial 1 Homo sapiens 267-271 6776409-8 1980 In this respect, these factors have to be assigned to the EF2 type; we suppose that the ADP-ribosylatable structure arising so early in evolution is of fundamental importance for the elongation process. Adenosine Diphosphate 88-91 eukaryotic translation elongation factor 2 Homo sapiens 58-61 6156907-3 1980 Two parameters of toxin activity were followed: enzymatic activity, i.e., the adenosine diphosphate (ADP) ribosylation of elongation factor 2, and biological activity, i.e., inhibition of protein synthesis in cultured mouse fibroblasts. Adenosine Diphosphate 101-104 eukaryotic translation elongation factor 2 Mus musculus 122-141 6250824-7 1980 Enzymatic phosphorylation of ADP polymer by creatine kinase gave an ATP polymer with high biological activity: 480 mumol ATP/g polymer were transformed with yeast hexokinase. Adenosine Diphosphate 29-32 hexokinase Saccharomyces cerevisiae S288C 163-173 41710-11 1979 It is concluded that electrostatic interactions between this positively charged group and the negatively charged ATP and ADP molecules may be critical for the hydrolytic efficiency of myosin heads. Adenosine Diphosphate 121-124 myosin heavy chain 14 Homo sapiens 184-190 158379-8 1979 (3) At low temperature, the equilibrium M*.ATP in equilibrium M**.ADP.Pi is displaced to the left All the kinetic data obtained in this study are compatible with a simple pathway for the Mg2+-ATP hydrolysis by myosin and with sequential release of the reaction products. Adenosine Diphosphate 66-69 myosin heavy chain 14 Homo sapiens 210-216 15717703-4 2004 We have examined the influence of midazolam on adenosine diphosphate (ADP)-induced platelet surface P-selectin expression and platelet-leucocyte aggregation in whole blood. Adenosine Diphosphate 47-68 selectin P Homo sapiens 100-110 15717703-4 2004 We have examined the influence of midazolam on adenosine diphosphate (ADP)-induced platelet surface P-selectin expression and platelet-leucocyte aggregation in whole blood. Adenosine Diphosphate 70-73 selectin P Homo sapiens 100-110 15717703-9 2004 RESULTS: Midazolam significantly inhibited ADP-induced platelet P-selectin expression and attenuated platelet-leucocyte aggregation (mainly in neutrophils and monocytes) in a dose-dependent manner with a maximum inhibitory effect at 3 x 10(-4)M (P < 0.01). Adenosine Diphosphate 43-46 selectin P Homo sapiens 64-74 15717703-10 2004 CONCLUSIONS: This study demonstrated that midazolam decreases the ADP-induced expression of platelet surface P-selectin and platelet-leucocyte aggregation. Adenosine Diphosphate 66-69 selectin P Homo sapiens 109-119 15745319-2 2004 The effect of thrombin or ADP on the density of CD 62P has been determined. Adenosine Diphosphate 26-29 selectin P Homo sapiens 48-54 479141-9 1979 Only a small amount of ADP, 0.07 mol per mol of myosin (Fig. Adenosine Diphosphate 23-26 myosin heavy chain 14 Homo sapiens 48-54 721806-3 1978 After [3H]ADP-ribosylation by [3H]nad+ and diphtheria toxin, EF-2 was digested with trypsin and a homogeneous [3H]ADP-ribosyl peptide was isolated by chromatography on DEAE-Sephadex and dihydroxyboryl-substituted cellulose. Adenosine Diphosphate 10-13 elongation factor 2 Saccharomyces cerevisiae S288C 61-65 623821-3 1978 It is shown that the chemical analogs of Mg2+-paramagnetic ion Mn2+ are directly connected with the myosin active centre in the presence of ATP(ADP), i. e. a triple complex enzyme-bivalent cation-substrate is formed. Adenosine Diphosphate 144-147 myosin heavy chain 14 Homo sapiens 100-106 144520-2 1977 14C-Labeled fluorodinitrobenzene and N-ethylmaleimide have been used as chemical probes of the conformational states of myosin induced by the binding of MgADP and MgATP. Adenosine Diphosphate 153-158 myosin heavy chain 14 Homo sapiens 120-126 15280395-5 2004 PKG I knock-out mouse platelets and PKG inhibitor-treated human platelets showed diminished aggregation-dependent secretion and also showed a diminished secondary wave of platelet aggregation induced by a TXA2 analog and thrombin receptor-activating peptides that were rescued by the granule content ADP. Adenosine Diphosphate 300-303 protein kinase cGMP-dependent 1 Homo sapiens 0-3 144520-4 1977 The binding of MgADP to myosin exposes the essential thiols as reflected by an increased rate of their modification. Adenosine Diphosphate 15-20 myosin heavy chain 14 Homo sapiens 24-30 334772-0 1977 Calorimetric studies of the ADP binding to myosin subfragment 1, heavy meromyosin, and to myosin filaments. Adenosine Diphosphate 28-31 myosin heavy chain 14 Homo sapiens 43-49 334772-0 1977 Calorimetric studies of the ADP binding to myosin subfragment 1, heavy meromyosin, and to myosin filaments. Adenosine Diphosphate 28-31 myosin heavy chain 14 Homo sapiens 75-81 334772-1 1977 A calorimetric titration method was used to study the ADP binding to the chymotryptic subfragments of myosin, heavy meromyosin (HMM) and myosin subfragment 1 (S-1), and to myosin aggregated into filaments at low ionic strength. Adenosine Diphosphate 54-57 myosin heavy chain 14 Homo sapiens 102-126 334772-1 1977 A calorimetric titration method was used to study the ADP binding to the chymotryptic subfragments of myosin, heavy meromyosin (HMM) and myosin subfragment 1 (S-1), and to myosin aggregated into filaments at low ionic strength. Adenosine Diphosphate 54-57 myosin heavy chain 14 Homo sapiens 102-108 334772-1 1977 A calorimetric titration method was used to study the ADP binding to the chymotryptic subfragments of myosin, heavy meromyosin (HMM) and myosin subfragment 1 (S-1), and to myosin aggregated into filaments at low ionic strength. Adenosine Diphosphate 54-57 myosin heavy chain 14 Homo sapiens 120-126 15280395-5 2004 PKG I knock-out mouse platelets and PKG inhibitor-treated human platelets showed diminished aggregation-dependent secretion and also showed a diminished secondary wave of platelet aggregation induced by a TXA2 analog and thrombin receptor-activating peptides that were rescued by the granule content ADP. Adenosine Diphosphate 300-303 protein kinase cGMP-dependent 1 Homo sapiens 36-39 15280395-7 2004 Furthermore PKG I knockout and PKG inhibitors significantly attenuated activation of the Gi pathway that is mediated by secreted ADP. Adenosine Diphosphate 129-132 protein kinase cGMP-dependent 1 Homo sapiens 12-15 849463-2 1977 Fragment A loses its ability to inactivate ADP-ribosylation of the elongation factor 2, as a function of the number of residues modified. Adenosine Diphosphate 43-46 eukaryotic translation elongation factor 2 Homo sapiens 67-86 15280395-7 2004 Furthermore PKG I knockout and PKG inhibitors significantly attenuated activation of the Gi pathway that is mediated by secreted ADP. Adenosine Diphosphate 129-132 protein kinase cGMP-dependent 1 Homo sapiens 31-34 137238-0 1976 Calorimetric studies of the interaction of myosin with ADP. Adenosine Diphosphate 55-58 myosin heavy chain 14 Homo sapiens 43-49 15351647-7 2004 According to crystallographic and tryptophan fluorescence studies, all of these analogs, except ATPgammaS and ADP, induce the "closed" conformation of the myosin head (in which the gamma phosphate pocket is closed). Adenosine Diphosphate 110-113 myosin heavy chain 14 Homo sapiens 155-161 137238-1 1976 A calorimetric titration method was used to study ADP binding to native myosin. Adenosine Diphosphate 50-53 myosin heavy chain 14 Homo sapiens 72-78 137238-2 1976 Data were analyzed by assuming that the myosin molecule has n independent and identical sites for ADP binding. Adenosine Diphosphate 98-101 myosin heavy chain 14 Homo sapiens 40-46 137238-5 1976 The average heat capacity change on ADP binding to myosin between 0 and 12 degrees is thus -1.4 +/- 0.4 kJ-mol-1-K-1. Adenosine Diphosphate 36-39 myosin heavy chain 14 Homo sapiens 51-57 137238-6 1976 Reasonably consistent results were obtained at 25 degrees, suggesting ADP binding to myosin is as strongly exothermic as at lower temperatures, although further interpretation of this result seems unwarranted, mainly because of the instability of myosic at this temperature. Adenosine Diphosphate 70-73 myosin heavy chain 14 Homo sapiens 85-91 137238-7 1976 The number of protons released on binding of ADP to myosin was determined in separate experiments. Adenosine Diphosphate 45-48 myosin heavy chain 14 Homo sapiens 52-58 15247300-3 2004 Here we show that the ADP produced by hexokinase activity in rat brain mitochondria (mt-hexokinase) controls both membrane potential (Deltapsi(m)) and ROS generation. Adenosine Diphosphate 22-25 hexokinase Saccharomyces cerevisiae S288C 38-48 1008824-7 1976 The binding of MgATP2-, MgADP-, ATP4- and MgPPi2- to "filamentous" myosin in both two- (myosin and nucleotide) and three- (myosin, nucleotide and PPi) component systems at different temperatures was studied and the dissociation constants obtained agreed well with previously published values. Adenosine Diphosphate 24-29 myosin heavy chain 14 Homo sapiens 67-73 1008824-7 1976 The binding of MgATP2-, MgADP-, ATP4- and MgPPi2- to "filamentous" myosin in both two- (myosin and nucleotide) and three- (myosin, nucleotide and PPi) component systems at different temperatures was studied and the dissociation constants obtained agreed well with previously published values. Adenosine Diphosphate 24-29 myosin heavy chain 14 Homo sapiens 88-94 1008824-7 1976 The binding of MgATP2-, MgADP-, ATP4- and MgPPi2- to "filamentous" myosin in both two- (myosin and nucleotide) and three- (myosin, nucleotide and PPi) component systems at different temperatures was studied and the dissociation constants obtained agreed well with previously published values. Adenosine Diphosphate 24-29 myosin heavy chain 14 Homo sapiens 88-94 14735-8 1976 It has also been found that at alkaline values of pH the power of myosin binding with ADP, a competitive inhibitor and the reaction product, is decreased. Adenosine Diphosphate 86-89 myosin heavy chain 14 Homo sapiens 66-72 7559-6 1976 Furthermore, the temporary cessation of alpha-NADH-dependent oxygen consumption caused by ferricyanide and the corresponding oxidation-reduction of reduced cytochrome b5 were followed in the presence of ADP. Adenosine Diphosphate 203-206 cytochrome b5 type A Homo sapiens 156-169 239944-1 1975 Myosin and subfragment 1 give a maximum burst size of 0.25 to 0.30 protons per active site at pH 8 with ATP, alpha,beta-methylene-ATP, ADP, and adenylyl imidodiphosphate as substrates. Adenosine Diphosphate 135-138 myosin heavy chain 14 Homo sapiens 0-6 1158863-7 1975 The binding of Mn2+ to the high affinity binding sites is not significantly influenced by ADP or PPi, although Mn2+ increases the affinity of ADP binding to myosin at high ionic strength. Adenosine Diphosphate 142-145 myosin heavy chain 14 Homo sapiens 157-163 16659239-8 1975 The ADP response, but not the ATP response, was considerably enhanced in the presence of an ATP-generating system (phosphoenolpyruvate/pyruvate kinase). Adenosine Diphosphate 4-7 pyruvate kinase Zea mays 135-150 125750-0 1975 A study of the binding of adenosine diphosphate to myosin subfragment-1. Adenosine Diphosphate 26-47 myosin heavy chain 14 Homo sapiens 51-57 1137991-0 1975 Proceedings: Elongation factor 2: amino acid sequence at the site of ADP-ribosylation. Adenosine Diphosphate 69-72 eukaryotic translation elongation factor 2 Homo sapiens 13-32 127887-0 1975 The binding of Mn2+ and ADP to myosin. Adenosine Diphosphate 24-27 myosin heavy chain 14 Homo sapiens 31-37 127887-4 1975 Binding of Mn2+ to the high affinity sites increases the affinity of ADP binding to myosin. Adenosine Diphosphate 69-72 myosin heavy chain 14 Homo sapiens 84-90 4276217-0 1974 The reaction of myosin with N-ethylmaleimide in the presence of ADP. Adenosine Diphosphate 64-67 myosin heavy chain 14 Homo sapiens 16-22 4838566-0 1974 [Heterogenicity of binding sites of adenosine diphosphate in myosin]. Adenosine Diphosphate 36-57 myosin heavy chain 14 Homo sapiens 61-67 4267755-0 1973 Cooperation between the two myosin heads interacting with actin in presence of ADP in myofibrils. Adenosine Diphosphate 79-82 myosin heavy chain 14 Homo sapiens 28-34 4259810-0 1972 Evidence for a complex between myosin and ADP in relaxed muscle fibres. Adenosine Diphosphate 42-45 myosin heavy chain 14 Homo sapiens 31-37 4255040-0 1971 Equilibrium and rapid kinetic studies of the effect of N-ethylmaleimide on the binding of ADP to myosin, and H-meromyosin. Adenosine Diphosphate 90-93 myosin heavy chain 14 Homo sapiens 97-103 4252707-0 1971 An attempt to detect phosphorylated myosin by ADP-ATP exchange. Adenosine Diphosphate 46-49 myosin heavy chain 14 Homo sapiens 36-42 4388010-3 1969 Erythrocyte glutathione synthetase is inhibited by ADP; this inhibition is competitive with respect to ATP. Adenosine Diphosphate 51-54 glutathione synthetase Homo sapiens 12-34 4303201-0 1969 The binding of ADP to myosin. Adenosine Diphosphate 15-18 myosin heavy chain 14 Homo sapiens 22-28 4226120-0 1967 On the interaction of adenosine diphosphate with myosin and its enzymically active fragments. Adenosine Diphosphate 22-43 myosin heavy chain 14 Homo sapiens 49-55 34043989-5 2021 An increase in AMP:ATP and ADP:ATP ratio leads to activation of AMPK signaling by upstream mediators such as LKB1 and CamKK. Adenosine Diphosphate 27-30 serine/threonine kinase 11 Homo sapiens 109-113 34043989-5 2021 An increase in AMP:ATP and ADP:ATP ratio leads to activation of AMPK signaling by upstream mediators such as LKB1 and CamKK. Adenosine Diphosphate 27-30 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 118-123 34029272-10 2021 On T3, significant reduction of PR in all three tests was observed (ASPI 10.4+-11.6 U (p=0.001), ADP 24.2+-14.1 U (p<0.001) and TRAP 69.3+-26.6 U (p<0.001)). Adenosine Diphosphate 97-100 transmembrane protein 37 Homo sapiens 32-34 33161021-2 2021 ATP is released from cells under physiologic and pathophysiologic condition; extracellular ATP is rapidly degraded to adenosine 5"-diphosphate (ADP) and adenosine by ecto-enzymes (mainly, CD39 and CD73). Adenosine Diphosphate 144-147 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 188-192 33524787-4 2021 The main components of this system that will be presented in this review are: P1 and P2 receptors and the enzymatic cascade composed by CD39 (NTPDase; with ATP and ADP as a substrate), CD73 (5"-nucleotidase; with AMP as a substrate), and adenosine deaminase (ADA; with adenosine as a substrate). Adenosine Diphosphate 164-167 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 136-140 33717055-1 2020 Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase. Adenosine Diphosphate 23-26 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 97-126 33717055-7 2020 These ADP-selective inhibitory effects of bedaquiline on platelet activation were mimicked by wortmannin, an inhibitor of phosphatidylinositol 3-kinase (PI3-K), implicating PI3-K as being a common target of both agents, a contention that was confirmed by the observed inhibitory effects of bedaquiline on the phosphorylation of Akt1 following activation of platelets with ADP. Adenosine Diphosphate 6-9 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 122-151 15247300-3 2004 Here we show that the ADP produced by hexokinase activity in rat brain mitochondria (mt-hexokinase) controls both membrane potential (Deltapsi(m)) and ROS generation. Adenosine Diphosphate 22-25 hexokinase Saccharomyces cerevisiae S288C 88-98 15351859-5 2004 Whole blood platelet agglutination was tested by a platelet function assay.TRAP and - in trend - ADP induced p-selectin exposure was reduced by the atorvastatin pretreatment before clopidogrel was added. Adenosine Diphosphate 97-100 selectin P Homo sapiens 109-119 33082143-8 2020 Based on the measured run length and the relatively slow off-rate in ADP, we conclude that attachment of the tethered head is the rate limiting transition in the KIF1A stepping cycle. Adenosine Diphosphate 69-72 kinesin family member 1A Homo sapiens 162-167 15351859-6 2004 Combining clopidogrel with atorvastatin in the healthy individuals led to a further reduction in ADP-induced platelet p-selectin exposure. Adenosine Diphosphate 97-100 selectin P Homo sapiens 118-128 15258894-7 2004 LPA-stimulated platelet aggregation was mediated by the ADP-stimulated activation of the P2Y(1) and P2Y(12) receptors. Adenosine Diphosphate 56-59 purinergic receptor P2Y1 Homo sapiens 89-95 33284729-4 2022 Platelets from untreated blood samples and samples treated with either adenosine diphosphate (ADP) or thrombin receptor agonist peptide (TRAP) had surface GPIbalpha, activated GPIIb-IIIa, and P-selectin levels measured using flow cytometry. Adenosine Diphosphate 94-97 selectin P Homo sapiens 192-202 15487851-6 2004 Clopidogrel has additional effects on the ADP-induced expression of adhesion molecules (P-selectin, GPIIb/IIIa) and inflammatory mediators (CD40L). Adenosine Diphosphate 42-45 selectin P Homo sapiens 88-98 15265806-0 2004 Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation. Adenosine Diphosphate 74-77 purinergic receptor P2Y1 Homo sapiens 41-45 33255391-8 2020 Optimal mobilization of CD62P by ADP-stimulated platelets is critically dependent on the co-activation of platelet P2Y1 and P2Y12 receptors. Adenosine Diphosphate 33-36 selectin P Homo sapiens 24-29 33255391-8 2020 Optimal mobilization of CD62P by ADP-stimulated platelets is critically dependent on the co-activation of platelet P2Y1 and P2Y12 receptors. Adenosine Diphosphate 33-36 purinergic receptor P2Y1 Homo sapiens 115-119 15243297-4 2004 When rings were tonically contracted by U46619 a thromboxane A2 analogue, ATP, ADP, ATP gamma S, 2-(methylthio)adenosine 5"-diphosphate, and UTP caused endothelium-dependent but not independent relaxations.I conclude that ATP acts on P2Y2 and P2Y1 receptors on the endothelial cells to cause endothelium-dependent relaxation. Adenosine Diphosphate 79-82 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 243-247 15354262-5 2004 The P2Y (1) receptor, through activation of G (q) and phospholipase C, is required for ADP-induced platelet shape change, fibrinogen receptor activation, and TXA (2) generation. Adenosine Diphosphate 87-90 purinergic receptor P2Y1 Homo sapiens 4-20 33010234-11 2020 The initial tension fall was caused by detachment of M ADP Pi myosin heads from actin and reversal of the first tension-generating step. Adenosine Diphosphate 55-58 myosin heavy chain 14 Homo sapiens 62-68 15193995-6 2004 PIT also concentration-dependently blocked the P2Y(1) receptor signaling induced by the endogenous agonists, ADP and ATP. Adenosine Diphosphate 109-112 purinergic receptor P2Y1 Homo sapiens 47-62 32897722-8 2020 We conclude that the time-averaged stiffness of the slow myosin is lower due to the prolonged duration of the AM.ADP state, which determines the force-generating potential and contraction speed of the muscle, elucidating the basis for functional diversity among myosins. Adenosine Diphosphate 113-116 myosin heavy chain 14 Homo sapiens 57-63 15223329-2 2004 In carrying out these functions Hsp90 hydrolyses ATP as it cycles between ADP- and ATP-bound forms, and this ATPase activity is regulated by the transient association with a variety of co-chaperones. Adenosine Diphosphate 74-77 heat shock protein 90 alpha family class A member 1 Homo sapiens 32-37 15136763-0 2004 Restoration of wild-type conformation to full-length and truncated p53 proteins: specific effects of ATP and ADP. Adenosine Diphosphate 109-112 transformation related protein 53, pseudogene Mus musculus 67-70 15136763-6 2004 We demonstrate a difference in the dose-dependent effect of ATP and ADP on renaturation of full-length wild-type and monomeric p53 proteins. Adenosine Diphosphate 68-71 transformation related protein 53, pseudogene Mus musculus 127-130 15207836-3 2004 Assays were performed in purified brain cell nuclei to determine Parp activity by incorporation of radiolabeled ADP-ribose moieties from nicotinamide adenine dinucleotide (NAD+) into nuclear proteins. Adenosine Diphosphate 112-115 poly (ADP-ribose) polymerase 1 Rattus norvegicus 65-69 15184020-5 2004 The K(d) values for ADP-binding to wild-type ORC and to ORC-1A (ORC containing Orc1p with a defective Walker A motif) were less than 10nM, showing that Orc5p can bind to ADP with a high affinity, similar to ATP. Adenosine Diphosphate 20-23 origin recognition complex subunit 5 Saccharomyces cerevisiae S288C 152-157 15184020-5 2004 The K(d) values for ADP-binding to wild-type ORC and to ORC-1A (ORC containing Orc1p with a defective Walker A motif) were less than 10nM, showing that Orc5p can bind to ADP with a high affinity, similar to ATP. Adenosine Diphosphate 170-173 origin recognition complex subunit 5 Saccharomyces cerevisiae S288C 152-157 15203713-9 2004 We conclude that ADP released from red blood cells enhances PMP formation induced by collagen, and that both P2Y12 and P2Y1 contribute to ADP-potentiation of PMP generation induced by collagen. Adenosine Diphosphate 138-141 purinergic receptor P2Y1 Homo sapiens 109-113 15130768-5 2004 Intact COS-7 cells transfected with an expression vector containing the coding sequence for mouse NTPDase3 hydrolyzed P2 receptor agonists (ATP, UTP, ADP and UDP) but not AMP. Adenosine Diphosphate 150-153 ectonucleoside triphosphate diphosphohydrolase 3 Mus musculus 98-106 15130768-9 2004 At pH 7.4 mouse NTPDase3 hydrolyzed ATP, UTP, ADP and UDP according to Michaelis-Menten kinetics with apparent K(m)s of 11, 10, 19 and 27 microM, respectively. Adenosine Diphosphate 46-49 ectonucleoside triphosphate diphosphohydrolase 3 Mus musculus 16-24 14998997-9 2004 Furthermore, in contrast to the ADP/ATP carrier, the Ggc1p-mediated GTP/GDP heteroexchange is H(+)-compensated and thus electroneutral. Adenosine Diphosphate 32-35 Ggc1p Saccharomyces cerevisiae S288C 53-58 15116258-6 2004 The purified IgG containing both anti-CL/beta2-GPI and anti-PS/PT caused significant enhancement of platelet activation caused by ADP. Adenosine Diphosphate 130-133 apolipoprotein H Homo sapiens 41-50 15118653-3 2004 RESULTS: Basal platelet expression of CD61, CD42a and CD62P, and adenosine diphosphate-stimulated CD62P expression were increased in women with preeclampsia compared with normotensive pregnant women. Adenosine Diphosphate 65-86 selectin P Homo sapiens 98-103 15194228-9 2004 The reduction of ADP activation in D172Y mutant was more profoundly observed in hGDH2 than in hGDH1. Adenosine Diphosphate 17-20 glutamate dehydrogenase 1 Homo sapiens 94-99 15064342-1 2004 PURPOSE: Ecto-ADPase (NTPDase1 or CD39) has been identified on endothelial cells and found to be antithrombogenic, with actions resulting from degradation of adenosine diphosphate (ADP), a thrombogenic molecule secreted by activated platelets at sites of vascular injury. Adenosine Diphosphate 158-179 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 22-30 15064342-1 2004 PURPOSE: Ecto-ADPase (NTPDase1 or CD39) has been identified on endothelial cells and found to be antithrombogenic, with actions resulting from degradation of adenosine diphosphate (ADP), a thrombogenic molecule secreted by activated platelets at sites of vascular injury. Adenosine Diphosphate 158-179 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 34-38 15064342-1 2004 PURPOSE: Ecto-ADPase (NTPDase1 or CD39) has been identified on endothelial cells and found to be antithrombogenic, with actions resulting from degradation of adenosine diphosphate (ADP), a thrombogenic molecule secreted by activated platelets at sites of vascular injury. Adenosine Diphosphate 14-17 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 22-30 15064342-1 2004 PURPOSE: Ecto-ADPase (NTPDase1 or CD39) has been identified on endothelial cells and found to be antithrombogenic, with actions resulting from degradation of adenosine diphosphate (ADP), a thrombogenic molecule secreted by activated platelets at sites of vascular injury. Adenosine Diphosphate 14-17 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 34-38 14758478-6 2004 ATP, ADP, AMP and AMP-PNP all quickly and reversibly inhibited TRPM4 with IC(50) values between 2 and 19 microM (at +100 mV). Adenosine Diphosphate 5-8 transient receptor potential cation channel subfamily M member 4 Homo sapiens 63-68 14982777-1 2004 Geldanamycin (GA) is an antibiotic targeting the ADP/ATP binding site of heat shock protein 90 (Hsp90). Adenosine Diphosphate 49-52 heat shock protein 90 alpha family class A member 1 Homo sapiens 73-94 14982777-1 2004 Geldanamycin (GA) is an antibiotic targeting the ADP/ATP binding site of heat shock protein 90 (Hsp90). Adenosine Diphosphate 49-52 heat shock protein 90 alpha family class A member 1 Homo sapiens 96-101 14715644-7 2004 Exposure to EETs inhibited platelet P-selectin expression in response to ADP. Adenosine Diphosphate 73-76 selectin P Homo sapiens 36-46 14623889-7 2004 However, ADP caused Akt phosphorylation in Galphaq- and P2Y1-deficient platelets, which was completely blocked by AR-C69931MX. Adenosine Diphosphate 9-12 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 56-60 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 cyclin dependent kinase 20 Homo sapiens 80-83 14718252-3 2004 In response to ADP and its analogues, in serum-starved cells, both p44 ERK1 and p42 ERK2 were activated in a time-dependent manner, as monitored by Western blot analysis using an antiphospho-p42/p44 MAPK antibody. Adenosine Diphosphate 15-18 cyclin dependent kinase 20 Homo sapiens 191-194 14718252-10 2004 Blocking of the P2Y1 receptor by MRS2179 additionally increased this ADP response. Adenosine Diphosphate 69-72 purinergic receptor P2Y1 Homo sapiens 16-29 14602724-8 2004 Despite persistent receptor activation, the association of IRS-1 with G(i)alpha(2) is transient, being optimal at 5 min and 1 nmol/liter insulin, which is sufficient to suppress Ca(2+) signaling by ADP, and at 10 min and 100 nmol/liter insulin, which is required to suppress Ca(2+) signaling by thrombin. Adenosine Diphosphate 198-201 insulin receptor substrate 1 Homo sapiens 59-64 14578486-6 2004 Recordings from mutant mice lacking phospholipase C(beta1) (PLC(beta1)) showed that mGluR block of the mAHP, as well as induction of the ADP, depended on the phosphoinositide hydrolysis pathway. Adenosine Diphosphate 137-140 hemoglobin, beta adult major chain Mus musculus 36-57 15166949-4 2004 Platelet reactivity was assessed as GPIIb/IIIa activation and P-selectin expression in platelets stimulated with 2 micromol/l adenosine diphosphate using whole blood flow cytometry. Adenosine Diphosphate 126-147 selectin P Homo sapiens 62-72 14979400-7 2004 Flow cytometry demonstrated a significant reduction in ADP-induced platelet P-selectin expression and GPIIb/IIIa activation following treatment with clopidogrel but not with placebo. Adenosine Diphosphate 55-58 selectin P Homo sapiens 76-86 14994994-1 2004 DNA damage-activated homodimer of PARP-1 binds to single-strand breaks and catalyzes the synthesis and transfer of negatively charged ADP-ribose polymers to nuclear protein acceptors, including itself. Adenosine Diphosphate 134-137 poly (ADP-ribose) polymerase 1 Rattus norvegicus 34-40 14692967-5 2004 During storage, thrombin- and ADP-induced Ca2+ signal generation consistently decreased in apheresis and pooled PLTs, which was accompanied by lower agonist-induced CD62 exposure and alpha IIb beta 3 activation. Adenosine Diphosphate 30-33 selectin P Homo sapiens 165-169 14692978-10 2004 Moreover, P-selectin release after ADP stimulation was reduced in plateletpheresis units obtained using the Trima device. Adenosine Diphosphate 35-38 selectin P Homo sapiens 10-20 14522996-1 2003 Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Adenosine Diphosphate 182-185 sirtuin 2 Homo sapiens 0-30 14522996-1 2003 Silent information regulator 2 (Sir2) enzymes catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Adenosine Diphosphate 182-185 sirtuin 2 Homo sapiens 32-36 14530868-7 2003 H. polymorpha hexokinase was inhibited by trehalose-6-phosphate ( K(i)=12 microM) and ADP ( K(i)=1.6 mM), but not by glucose-6-phosphate. Adenosine Diphosphate 86-89 hexokinase Saccharomyces cerevisiae S288C 14-24 14622256-2 2003 The antibiotics geldanamycin and radicicol act as highly selective inhibitors of in vivo Hsp90 function through their ability to bind within the ADP/ATP binding pocket of the chaperone. Adenosine Diphosphate 145-148 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 89-94 12907444-2 2003 The P2X1 receptor is an adenosine triphosphate (ATP)-gated ion channel that mediates a rapid calcium influx signal, but can also synergize with subsequent adenosine diphosphate (ADP)-evoked P2Y1 receptor-mediated responses and thus may contribute to platelet activation during hemostasis. Adenosine Diphosphate 155-176 purinergic receptor P2X 1 Homo sapiens 4-17 12907444-2 2003 The P2X1 receptor is an adenosine triphosphate (ATP)-gated ion channel that mediates a rapid calcium influx signal, but can also synergize with subsequent adenosine diphosphate (ADP)-evoked P2Y1 receptor-mediated responses and thus may contribute to platelet activation during hemostasis. Adenosine Diphosphate 155-176 purinergic receptor P2Y1 Homo sapiens 190-203 12907444-2 2003 The P2X1 receptor is an adenosine triphosphate (ATP)-gated ion channel that mediates a rapid calcium influx signal, but can also synergize with subsequent adenosine diphosphate (ADP)-evoked P2Y1 receptor-mediated responses and thus may contribute to platelet activation during hemostasis. Adenosine Diphosphate 178-181 purinergic receptor P2X 1 Homo sapiens 4-17 12907444-2 2003 The P2X1 receptor is an adenosine triphosphate (ATP)-gated ion channel that mediates a rapid calcium influx signal, but can also synergize with subsequent adenosine diphosphate (ADP)-evoked P2Y1 receptor-mediated responses and thus may contribute to platelet activation during hemostasis. Adenosine Diphosphate 178-181 purinergic receptor P2Y1 Homo sapiens 190-203 14746803-3 2003 Using DD-PCR analysis, adenine nucleotide translocase (ANT) 3, an enzyme which exchanges ATP and ADP through mitochondrial membrane, has been identified as a novel target counter-regulated by IL-4 and IFN-gamma. Adenosine Diphosphate 97-100 solute carrier family 25 member 6 Homo sapiens 23-61 14622282-4 2003 In the resting state of TAP, the NBD1 has a much higher binding activity for ATP than the NBD2, while the binding of ADP to the two NBDs is equivalent. Adenosine Diphosphate 117-120 filamin B Homo sapiens 24-27 14713514-4 2003 P2Y1 receptor agonist concentrations that elicited aggregation (pEC50 for ADP, 2-MeSADP; 5.88, 6.69) were 10-fold greater than those that elicited SC (7.33, 7.67). Adenosine Diphosphate 74-77 purinergic receptor P2Y1 Homo sapiens 0-13 14556632-0 2003 Modulation of kinesin half-site ADP release and kinetic processivity by a spacer between the head groups. Adenosine Diphosphate 32-35 Kinesin light chain Drosophila melanogaster 14-21 32730244-0 2020 ADP is the dominant controller of AMP-activated protein kinase activity dynamics in skeletal muscle during exercise. Adenosine Diphosphate 0-3 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 34-62 32730244-3 2020 AMPK activity dynamics are primarily controlled by the adenine nucleotides ADP and AMP, but how each contributes to its control in skeletal muscle during exercise is unclear. Adenosine Diphosphate 75-78 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-4 32730244-4 2020 We developed and validated a mathematical model of AMPK signaling dynamics, and then applied global parameter sensitivity analyses with data-informed constraints to predict that AMPK activity dynamics are determined principally by ADP and not AMP. Adenosine Diphosphate 231-234 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 178-182 32730244-7 2020 Despite AMP"s favorable values in three of these four properties, ADP is the dominant controller of AMPK activity dynamics in skeletal muscle during exercise by virtue of its higher concentration compared to that of AMP. Adenosine Diphosphate 66-69 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 100-104 32714761-3 2020 Here, crystal structures of human DDX21 determined in three distinct states are reported, including the apo-state, the AMPPNP plus single-stranded RNA (ssRNA) bound pre-hydrolysis state, and the ADP-bound post-hydrolysis state, revealing an open to closed conformational change upon RNA binding and unwinding. Adenosine Diphosphate 195-198 DExD-box helicase 21 Homo sapiens 34-39 32537460-5 2020 Based on P-VASP and LTA findings, platelet response to ADP was significantly attenuated after 7 days of clopidogrel treatment. Adenosine Diphosphate 55-58 vasodilator stimulated phosphoprotein Felis catus 11-15 31793068-7 2020 Thus, PARP1 ADP-ribosylates H2B to negatively regulate NFATc1 expression and OC differentiation. Adenosine Diphosphate 12-31 poly (ADP-ribose) polymerase family, member 1 Mus musculus 6-11 32060423-9 2020 Interestingly, PLK1 is mono-ADP-ribosylated by PARP10 and the MARylation of PLK1 significantly inhibits its kinase activity and oncogenic function in HCC. Adenosine Diphosphate 28-31 polo like kinase 1 Homo sapiens 15-19 31926163-4 2020 SIRT6, which is an ADP-ribosyltransferase and NAD+-dependent deacetylase of acetyl and long-chain fatty acyl groups, playing central roles in lipid and glucose metabolism, is closely related to the occurrence of diabetes and obesity caused by overnutrition and aging. Adenosine Diphosphate 19-22 sirtuin 6 Bos taurus 0-5 31911551-0 2020 Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation. Adenosine Diphosphate 66-69 nudix hydrolase 16 Homo sapiens 16-22 31911551-10 2020 In summary, we demonstrate that NUDT16 regulates 53BP1 stability and 53BP1 recruitment at double-strand breaks, providing yet another mechanism of 53BP1 regulation.Significance: This study provides a novel mechanism of 53BP1 regulation by demonstrating that NUDT16 has hydrolase activities that remove ADP-ribosylation of 53BP1 to regulate 53BP1 stability and 53BP1 localization at DSBs. Adenosine Diphosphate 302-305 nudix hydrolase 16 Homo sapiens 32-38 31911551-10 2020 In summary, we demonstrate that NUDT16 regulates 53BP1 stability and 53BP1 recruitment at double-strand breaks, providing yet another mechanism of 53BP1 regulation.Significance: This study provides a novel mechanism of 53BP1 regulation by demonstrating that NUDT16 has hydrolase activities that remove ADP-ribosylation of 53BP1 to regulate 53BP1 stability and 53BP1 localization at DSBs. Adenosine Diphosphate 302-305 nudix hydrolase 16 Homo sapiens 258-264 32092898-2 2020 ADP-ribosylarginine hydrolase 1 (ARH1) catalyzes the cleavage of the ADP-ribose-arginine bond, regenerating (arginine)protein. Adenosine Diphosphate 0-3 ADP-ribosylarginine hydrolase Homo sapiens 33-37 32092898-8 2020 In the myocardium, in response to cellular injury, an arginine-specific mono-ADP-ribosylation cycle, involving ART1 and ARH1, regulated the level and cellular distribution of ADP-ribosylated tripartite motif-containing protein 72 (TRIM72). Adenosine Diphosphate 77-80 ADP-ribosylarginine hydrolase Homo sapiens 120-124 32092898-8 2020 In the myocardium, in response to cellular injury, an arginine-specific mono-ADP-ribosylation cycle, involving ART1 and ARH1, regulated the level and cellular distribution of ADP-ribosylated tripartite motif-containing protein 72 (TRIM72). Adenosine Diphosphate 77-80 tripartite motif containing 72 Homo sapiens 231-237 31843644-6 2020 Mutation of certain residues at the active site suggests that mono ADP-ribosylation and deacetylation are two distinct activities of SIRT7. Adenosine Diphosphate 67-70 sirtuin 7 Homo sapiens 133-138 31843644-14 2020 Finally, we can also relate SIRT7 to the DNA repair process through ADP ribosylation of one of its key players, PARP1. Adenosine Diphosphate 68-71 sirtuin 7 Homo sapiens 28-33 32046066-3 2020 It has been shown that TRPM2 cation channels and CD38, a type II or type III transmembrane protein with ADP-ribosyl cyclase activity, simultaneously play a role in heat-sensitive and NAD+ metabolite-dependent intracellular free Ca2+ concentration increases in hypothalamic oxytocinergic neurons. Adenosine Diphosphate 104-107 transient receptor potential cation channel subfamily M member 2 Homo sapiens 23-28 31800116-8 2020 Driven by ATP binding and hydrolysis and GroES binding, GroEL undergoes a catalytic cycle during which it samples three allosteric states, T (apo), R (ATP bound), and R"" (ADP bound). Adenosine Diphosphate 172-175 heat shock protein family D (Hsp60) member 1 Homo sapiens 56-61 31901221-6 2020 We demonstrated that Syk phosphorylation at Tyr525+526 also happens in the presence of ADP and TXA2 inhibitors, which is not the case for Src-pTyr419 and PLCgamma2-pTyr759. Adenosine Diphosphate 87-90 spleen associated tyrosine kinase Homo sapiens 21-24 31909710-2 2020 ATP/ADP binding to Kir6.2 shuts KATP. Adenosine Diphosphate 4-7 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 19-25 31903135-12 2020 Expression of ANKRD22 promoted glycolysis associated with a decrease in ATP/ADP and an increase in AMP/ATP levels, which were related to its interaction with pyruvate dehydrogenase kinase isoform 1 (PDK1) and multiple subunits of ATP synthase. Adenosine Diphosphate 76-79 ankyrin repeat domain 22 Homo sapiens 14-21 31591270-0 2019 Interaction of the N terminus of ADP-ribosylation factor with the PH domain of the GTPase-activating protein ASAP1 requires phosphatidylinositol 4,5-bisphosphate. Adenosine Diphosphate 33-36 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Homo sapiens 109-114 31591270-1 2019 ArfGAP with SH3 domain, ankyrin repeat, and PH domain 1 (ASAP1) is a multidomain GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF)-type GTPases. Adenosine Diphosphate 117-120 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Homo sapiens 57-62 31547977-1 2019 BACKGROUND: Dependent on the extent of adenosine triphosphate (ATP) hydrolysis and/or ATP/ADP exchange, the stress-induced phosphoprotein 1 (STIP1) mediates molecular interaction and complex formation between the molecular chaperones heat shock protein (Hsp)70 and Hsp90. Adenosine Diphosphate 90-93 heat shock protein family A (Hsp70) member 4 Homo sapiens 234-260 31418386-6 2019 RESULTS: After the ADP activation, the expression level of GPIb significantly decreased, while the expression levels of GPIb, GPIIb/III a and P-selectin significantly increased in control group, nothing bleeding symptom group and mild bleeding symptom group; but the expression level of GPIb significantly increased, while the expression level of GPIIb/III a significantly decreased in moderate and severe bleeding symptom group, the both differences were statistically significant (P<0.05). Adenosine Diphosphate 19-22 integrin subunit alpha 2b Homo sapiens 347-352 31418386-9 2019 After ADP activation, the expression levels of GPIb and P-selectin in ITP subgroups both were lower than those in control group, the expression level of GPIIb/IIIa in ITP subgroups was higher than that in control group (P<0.05). Adenosine Diphosphate 6-9 integrin subunit alpha 2b Homo sapiens 153-158 30926389-10 2019 Eventually, the presence of multiple rare sequence variants in the Solute Carrier Family 25 Member 5 (SLC25A5) gene is suggestive of the role of this gene as a key factor linking mitochondria metabolism, ADP/ATP ratio and oxidative stress thus affecting extracellular matrix homeostasis and activation of pro-osteogenic factors. Adenosine Diphosphate 204-207 solute carrier family 25 member 5 Homo sapiens 67-100 30926389-10 2019 Eventually, the presence of multiple rare sequence variants in the Solute Carrier Family 25 Member 5 (SLC25A5) gene is suggestive of the role of this gene as a key factor linking mitochondria metabolism, ADP/ATP ratio and oxidative stress thus affecting extracellular matrix homeostasis and activation of pro-osteogenic factors. Adenosine Diphosphate 204-207 solute carrier family 25 member 5 Homo sapiens 102-109 31247943-6 2019 In our molecular docking simulations, we found that HSP70 in the ATP-bound state presents a better docking score towards the TLR4/MD2 complex compared to the ADP-bound state (-22.60 vs. -10.29 kcal/mol, respectively). Adenosine Diphosphate 158-161 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-57 14556632-7 2003 The constructs with long insertion, however, rapidly release both ADP molecules per dimer on binding to a MT, indicating that the steric constraints that prevent release of ADP from the tethered head of wild-type kinesin have been relieved by the long insertions. Adenosine Diphosphate 173-176 Kinesin light chain Drosophila melanogaster 213-220 12963061-9 2003 Adp may well be the fluorophore of choice for fTHPs, as (a) fTHPs incorporating Adp were obtained in significantly higher yields than the Amp-containing fTHPs, (b) Adp has a larger Stokes shift than either Amp or Lys(Mca) and thus has less chance of self-quenching, (c) Adp has a relatively high quantum yield, (d) the Adp/Dnp pair is compatible with multiwell plate reader formats, and (e) MMPs better tolerate Adp than Lys(Mca). Adenosine Diphosphate 0-3 matrix metallopeptidase 1 Homo sapiens 391-395 31009511-7 2019 Moreover, the activation of platelets by DENV NS1 promoted subthreshold concentrations of adenosine diphosphate (ADP)-induced platelet aggregation and enhanced platelet adhesion to endothelial cells and phagocytosis by macrophages. Adenosine Diphosphate 90-111 influenza virus NS1A binding protein Mus musculus 46-49 31009511-7 2019 Moreover, the activation of platelets by DENV NS1 promoted subthreshold concentrations of adenosine diphosphate (ADP)-induced platelet aggregation and enhanced platelet adhesion to endothelial cells and phagocytosis by macrophages. Adenosine Diphosphate 113-116 influenza virus NS1A binding protein Mus musculus 46-49 30760523-6 2019 Moreover, multiple GPCRs agonists, including thrombin, histamine, prostaglandin E2, and ADP, stimulated robust p38 autophosphorylation, whereas phosphorylation of the upstream MAPKs MAP kinase kinase 3 (MKK3) and MKK6, was virtually undetectable, indicating that non-canonical p38 activation may exist for other GPCRs. Adenosine Diphosphate 88-91 mitogen-activated protein kinase kinase 3 Homo sapiens 182-201 14507711-2 2003 Using the in vitro motility assay, myosin strong binding to the thin filament was controlled by three mechanisms: 1), varying the myosin concentration of the motility surface, and adding either 2), inorganic phosphate (Pi) or 3), adenosine diphosphate (ADP) to the motility solutions. Adenosine Diphosphate 230-251 myosin heavy chain 14 Homo sapiens 35-41 30760523-6 2019 Moreover, multiple GPCRs agonists, including thrombin, histamine, prostaglandin E2, and ADP, stimulated robust p38 autophosphorylation, whereas phosphorylation of the upstream MAPKs MAP kinase kinase 3 (MKK3) and MKK6, was virtually undetectable, indicating that non-canonical p38 activation may exist for other GPCRs. Adenosine Diphosphate 88-91 mitogen-activated protein kinase kinase 3 Homo sapiens 203-207 30281799-4 2019 We show that at 4 C the plant mitochondrial ATP synthase is differentially inhibited compared with other elements of the respiratory pathway, leading to decreased ADP : oxygen ratios and a limitation to the rate of ATP synthesis. Adenosine Diphosphate 163-166 ATP synthase Arabidopsis thaliana 44-56 14507711-2 2003 Using the in vitro motility assay, myosin strong binding to the thin filament was controlled by three mechanisms: 1), varying the myosin concentration of the motility surface, and adding either 2), inorganic phosphate (Pi) or 3), adenosine diphosphate (ADP) to the motility solutions. Adenosine Diphosphate 253-256 myosin heavy chain 14 Homo sapiens 35-41 14507711-6 2003 Thus by limiting or increasing myosin strong binding (with the addition of Pi and ADP, respectively), the calcium concentration at which half maximal activation of the thin filament is achieved can be modulated. Adenosine Diphosphate 82-85 myosin heavy chain 14 Homo sapiens 31-37 14522842-7 2003 oATP had no effect on uridine triphosphate-induced activation of native P2Y2 receptors in HEK cells, but reduced the potency and efficacy of ADP as an agonist of native P2Y1 receptors. Adenosine Diphosphate 141-144 purinergic receptor P2Y1 Homo sapiens 169-173 12974724-8 2003 Percentage of CD62-positive monocytes (CD14+ particles) increased from baseline 5% to 13 +/- 6% in ADP-stimulated samples to 53 +/- 17% after isolation (P < 0.001). Adenosine Diphosphate 99-102 selectin P Homo sapiens 14-18 14529387-4 2003 In addition, direct binding of radicicol to the N-terminal ATP/ADP binding site of Hsp90 was shown, and thus radicicol has been recognized as a structurally unique antibiotic that binds and inhibits the molecular chaperone Hsp90. Adenosine Diphosphate 63-66 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-88 14522569-6 2003 ADP-stimulated (1, 10, 100 micromol/l) expression of P-selectin (CD62P) on platelets was measured by flow cytometry, and used as a marker for the antiplatelet effect of clopidogrel. Adenosine Diphosphate 0-3 selectin P Homo sapiens 53-63 14522569-6 2003 ADP-stimulated (1, 10, 100 micromol/l) expression of P-selectin (CD62P) on platelets was measured by flow cytometry, and used as a marker for the antiplatelet effect of clopidogrel. Adenosine Diphosphate 0-3 selectin P Homo sapiens 65-70 12964162-0 2003 NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol. Adenosine Diphosphate 88-91 heat shock protein 90 alpha family class A member 1 Homo sapiens 66-71 12913786-2 2003 When platelets become activated by various soluble agonists or by adhesion to subendothelium under high shear, they release adenosine-5"-diphosphate that acts in a positive feedback mechanism on two different G-protein coupled receptors (P2Y(12), P2Y(1)) on platelets. Adenosine Diphosphate 124-148 purinergic receptor P2Y1 Homo sapiens 247-253 14501955-10 2003 Immunohistochemistry showed positive staining for nitrotyrosine and poly(adenosine diphosphate [ADP]-ribose) polymerase-1 (PARP-1) in thoracic aortas. Adenosine Diphosphate 73-94 poly (ADP-ribose) polymerase 1 Rattus norvegicus 123-129 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 64-67 adenylate kinase 1 Mus musculus 5-8 12730234-3 2003 M-CK/AK1 (MAK=/=) mutant skeletal muscle displayed aberrant ATP/ADP, ADP/AMP and ATP/GTP ratios, reduced intracellular phosphotransfer communication, and increased ATP supply capacity as assessed by 18O labeling of [Pi] and [ATP]. Adenosine Diphosphate 69-72 adenylate kinase 1 Mus musculus 5-8 12878186-6 2003 ATPDase, which is present on the outer surface of endothelial cells lining human blood vessels, has been implicated in thromboregulation by promoting ADP hydrolysis and inhibition of platelet aggregation. Adenosine Diphosphate 150-153 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-7 12814667-1 2003 The Gi-linked platelet ADP receptor, now designated as P2Y12, accounts for ADP-induced inhibition of adenylyl cyclase in platelets and certain clonal rat cell lines. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Rattus norvegicus 55-60 12729599-6 2003 Geldanamycin, ADP, ATP, and radicicol-all known to bind to the ATP domain of Hsp90-competed with [3H]AAG for binding to hHsp90alpha9-236, showing K(d) values in good agreement with reported values. Adenosine Diphosphate 14-17 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 12781988-3 2003 To identify genes expressed by reactive astrocytes, we employed an in vivo model of the glial scar and differential display PCR and found an increase in the level of Ant1, a mitochondrial ATP/ADP exchanger that facilitates the flux of ATP out of the mitochondria. Adenosine Diphosphate 192-195 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 166-170 12654915-5 2003 Based on binding experiments with peptides and polypeptides we propose here a novel mechanism for the targeting action of DnaJ: ATP.DnaK and DnaJ with its substrate-binding domain bind to different segments of one and the same polypeptide chain forming (ATP.DnaK)m.substrate.DnaJn complexes; in these ternary complexes efficient cis-interaction of the J-domain of DnaJ with DnaK is favored by their propinquity and triggers the hydrolysis of DnaK-bound ATP, converting DnaK to its ADP-liganded high affinity state and thus locking it onto the substrate polypeptide. Adenosine Diphosphate 481-484 DnaJ Escherichia coli 122-126 12729766-8 2003 The rate of ADP release from Chara myosin after the completion of the force-generation step was similar to that of myosin V, but was considerably slower than that of skeletal muscle myosin. Adenosine Diphosphate 12-15 myosin heavy chain 14 Homo sapiens 35-41 12729766-11 2003 As the load imposed on the myosin decreased, the rate of ADP release increased. Adenosine Diphosphate 57-60 myosin heavy chain 14 Homo sapiens 27-33 12679807-4 2003 Here we show that the swing of smooth muscle myosin lever arm requires both ADP and actin. Adenosine Diphosphate 76-79 myosin heavy chain 14 Homo sapiens 45-51 12681240-1 2003 Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin, thromboxane and collagen, is a major mechanism of platelet activation. Adenosine Diphosphate 61-64 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 14-20 12817809-6 2003 YM-254890 inhibited ADP-induced platelet aggregation in human platelet-rich plasma with an IC50 value below 0.6 microM by blocking the P2Y1 receptor-signal transduction pathway. Adenosine Diphosphate 20-23 purinergic receptor P2Y1 Homo sapiens 135-148 30650444-0 2019 Platelet Functions are Decreased in Obesity and Restored after Weight Loss: Evidence for a Role of the SERCA3-Dependent ADP Secretion Pathway. Adenosine Diphosphate 120-123 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 103-109 12649347-8 2003 A recombinant, soluble form of human CD39, solCD39, has enzymatic and biological properties identical to the full-length form of the molecule and strongly inhibits human platelet aggregation induced by ADP, collagen, arachidonate, or TRAP (thrombin receptor agonist peptide). Adenosine Diphosphate 202-205 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 37-41 30650444-9 2019 Interestingly, pharmacological inhibition of SERCA3 activity in control group"s platelets mimicked similar alterations than in obese patients" platelets and was associated with defective adenosine diphosphate (ADP) secretion. Adenosine Diphosphate 187-208 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 45-51 30650444-9 2019 Interestingly, pharmacological inhibition of SERCA3 activity in control group"s platelets mimicked similar alterations than in obese patients" platelets and was associated with defective adenosine diphosphate (ADP) secretion. Adenosine Diphosphate 210-213 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 45-51 30650444-10 2019 Addition of ADP to agonist restored platelet functions in obese patients and in SERCA3-inhibited control platelets (five experiments) confirming the direct involvement of the SERCA3-dependent ADP secretion pathway. Adenosine Diphosphate 12-15 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 80-86 30650444-10 2019 Addition of ADP to agonist restored platelet functions in obese patients and in SERCA3-inhibited control platelets (five experiments) confirming the direct involvement of the SERCA3-dependent ADP secretion pathway. Adenosine Diphosphate 12-15 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 175-181 30650444-10 2019 Addition of ADP to agonist restored platelet functions in obese patients and in SERCA3-inhibited control platelets (five experiments) confirming the direct involvement of the SERCA3-dependent ADP secretion pathway. Adenosine Diphosphate 192-195 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 175-181 30650444-11 2019 This is the first study demonstrating that platelets from obese patients are hypo-reactive, due to a deficiency of SERCA3-dependent ADP secretion. Adenosine Diphosphate 132-135 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 115-121 12634057-4 2003 The docking of the X-ray structure of N-D1 domains in an ADP bound state indicates that an upward repositioning of N domain is necessary to accommodate the cryo-EM map of "p97-AMP-PNP", suggesting a change in the orientation of N domains upon nucleotide hydrolysis. Adenosine Diphosphate 57-60 melanotransferrin Homo sapiens 172-175 29865042-6 2019 Of particular of interest, we also found that the formation of aggregates after stimulation of the platelets with ADP was higher in patients with atherosclerotic disease than the controls; indicating an inverse relationship between hSR-B1 expression and the function of human platelets. Adenosine Diphosphate 114-117 scavenger receptor class B member 1 Homo sapiens 232-238 29451832-8 2019 ADP activation of control samples significantly increased the KDR expression by CD34+ cells and the CD61+/KDR+ conjugates, these parameters being unaffected in patients at baseline but increased at follow-up. Adenosine Diphosphate 0-3 kinase insert domain receptor Homo sapiens 62-65 29451832-8 2019 ADP activation of control samples significantly increased the KDR expression by CD34+ cells and the CD61+/KDR+ conjugates, these parameters being unaffected in patients at baseline but increased at follow-up. Adenosine Diphosphate 0-3 kinase insert domain receptor Homo sapiens 106-109 12626998-10 2003 MEASUREMENTS AND MAIN RESULTS: Expression of GP IIb-IIIa and P-selectin on adenosine diphosphate-activated platelets and platelet-leukocyte aggregation were significantly lower after the passage of blood through the hemofilter in patients receiving an extracorporeal infusion of prostacyclin plus heparin when compared with control patients receiving heparin only. Adenosine Diphosphate 75-96 selectin P Homo sapiens 61-71 30686862-3 2018 Here we present a method that allows for spin-labeling of protein nucleotide binding sites by adenosine diphosphate (ADP) modified with a nitroxide moiety on the beta-phosphate (ADP-beta-S-SL). Adenosine Diphosphate 94-115 spindlin 1 Homo sapiens 41-45 30686862-3 2018 Here we present a method that allows for spin-labeling of protein nucleotide binding sites by adenosine diphosphate (ADP) modified with a nitroxide moiety on the beta-phosphate (ADP-beta-S-SL). Adenosine Diphosphate 117-120 spindlin 1 Homo sapiens 41-45 30188609-6 2018 We proved the elevated expression of the active form of integrin receptor GPIIb/IIIa, responsible for platelet aggregation, and in the kinetic test we confirmed the increased aggregation of platelets in different intracellular signal pathways (dependent on ADP, collagen, arachidonic acid). Adenosine Diphosphate 257-260 integrin subunit alpha 2b Homo sapiens 74-79 30372610-3 2018 The anticancer compound, MKT-077, is known to bind a conserved site in members of the Hsp70 family, which favors the ADP-bound state and interferes with a protein-protein interaction (PPI) at long range. Adenosine Diphosphate 117-120 heat shock protein family A (Hsp70) member 4 Homo sapiens 86-91 30372610-8 2018 Together, the results indicate that MKT-077 interacts with loop222 to favor a pseudo-ADP bound conformer of Hsp70"s NBD, even when ATP is present. Adenosine Diphosphate 85-88 heat shock protein family A (Hsp70) member 4 Homo sapiens 108-113 30337247-9 2018 SPR and ITC revealed a tight interaction between Hu-GPIbalpha and rLep-vWA-I/rLep-vWA-II with KD values of 3.87 x 10-7-8.65 x 10-8 M. Hu-GPIbalpha-binding of rL-vWA-I/rL-vWA-II neither activated the PI3K/AKT-ERK and PLC/PKC kinases nor affected the NO, cGMP, ADP, Ca2+ and TXA2 levels in Hu-platelets. Adenosine Diphosphate 259-262 glycoprotein Ib platelet subunit alpha Homo sapiens 52-61 30337247-9 2018 SPR and ITC revealed a tight interaction between Hu-GPIbalpha and rLep-vWA-I/rLep-vWA-II with KD values of 3.87 x 10-7-8.65 x 10-8 M. Hu-GPIbalpha-binding of rL-vWA-I/rL-vWA-II neither activated the PI3K/AKT-ERK and PLC/PKC kinases nor affected the NO, cGMP, ADP, Ca2+ and TXA2 levels in Hu-platelets. Adenosine Diphosphate 259-262 glycoprotein Ib platelet subunit alpha Homo sapiens 137-146 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Adenosine Diphosphate 199-202 ATP citrate lyase Homo sapiens 0-17 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Adenosine Diphosphate 199-202 ATP citrate lyase Homo sapiens 19-23 30053721-3 2018 Among them compound 15i (CHMFL-PI3KD-317) displays an IC50 of 6 nM against PI3Kdelta in the ADP-Glo biochemical assays. Adenosine Diphosphate 92-95 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Mus musculus 75-84 29784881-2 2018 In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor. Adenosine Diphosphate 53-56 ADP dependent glucokinase Homo sapiens 80-85 29968674-2 2018 Here, four crystal structures of Prp2 are reported: one of the nucleotide-free state and three different structures of the ADP-bound state. Adenosine Diphosphate 123-126 transmembrane protein 171 Homo sapiens 33-37 31819717-1 2018 VAN3 is a plant ACAP-type ADP-ribosylation factor-GTPase activating protein (ARF-GAP) that regulates auxin transport-mediated plant morphogenesis such as continuous venation and lateral root development in Arabidopsis. Adenosine Diphosphate 26-29 ARF GTPase-activating protein Arabidopsis thaliana 0-4 29805488-9 2018 Furthermore, a number of gene-drug interactions, including between HSP90B1 and adenosine-5"-diphosphate and radicicol, were identified. Adenosine Diphosphate 79-103 heat shock protein 90 beta family member 1 Homo sapiens 67-74 29415503-7 2018 After ATP is hydrolyzed to Adenosine diphosphate (ADP), HSP60 released the HSP10 and the dissociation of the double-ring to single-rings occurred. Adenosine Diphosphate 27-48 heat shock protein family D (Hsp60) member 1 Homo sapiens 56-61 29415503-7 2018 After ATP is hydrolyzed to Adenosine diphosphate (ADP), HSP60 released the HSP10 and the dissociation of the double-ring to single-rings occurred. Adenosine Diphosphate 50-53 heat shock protein family D (Hsp60) member 1 Homo sapiens 56-61 29323281-9 2018 The preferential interaction with BiP in its ADP state places Bap at a late stage of the chaperone cycle, in which it coordinates release of substrate and ADP, thereby resetting BiP for ATP and substrate binding. Adenosine Diphosphate 45-48 SIL1 nucleotide exchange factor Homo sapiens 62-65 29323281-9 2018 The preferential interaction with BiP in its ADP state places Bap at a late stage of the chaperone cycle, in which it coordinates release of substrate and ADP, thereby resetting BiP for ATP and substrate binding. Adenosine Diphosphate 155-158 SIL1 nucleotide exchange factor Homo sapiens 62-65 28972175-9 2017 This is the first report of a bacterial GDP-regulated thioesterase and of covalent linkage of thioesterase domains through a disulfide bond, revealing structural similarities with ADP regulation in the human ACOT12 thioesterase. Adenosine Diphosphate 180-183 acyl-CoA thioesterase 12 Homo sapiens 208-214 29230353-7 2017 Further, the microtubule-end specific stimulation of ADP dissociation, characteristic of MCAK, is abolished by this mutation. Adenosine Diphosphate 53-56 kinesin family member 2C Homo sapiens 89-93 29158484-4 2017 In response to DNA damage, activated and auto-poly-ADP-ribosylated PARP1 dissociates from HSF1-PARP13, and redistributes to DNA lesions and DNA damage-inducible gene loci. Adenosine Diphosphate 51-54 zinc finger CCCH-type containing, antiviral 1 Homo sapiens 95-101 28939772-7 2017 Our experiments suggest that an ADP-driven downward movement of the p97 N-terminal domain dislodges ataxin3 by inducing a steric clash between the D1-domain and ataxin3"s C terminus. Adenosine Diphosphate 32-35 ataxin 3 Homo sapiens 100-107 28939772-7 2017 Our experiments suggest that an ADP-driven downward movement of the p97 N-terminal domain dislodges ataxin3 by inducing a steric clash between the D1-domain and ataxin3"s C terminus. Adenosine Diphosphate 32-35 ataxin 3 Homo sapiens 161-168 29064388-7 2017 Furthermore, we demonstrate that platelet-derived ADP and ATP regulate Slug and CDD expression in pancreatic cancer cells. Adenosine Diphosphate 50-53 snail family transcriptional repressor 2 Homo sapiens 71-75 28994403-0 2017 Large-scale crystallization and neutron crystallographic analysis of HSP70 in complex with ADP. Adenosine Diphosphate 91-94 heat shock protein family A (Hsp70) member 4 Homo sapiens 69-74 12514117-0 2003 CD38/cyclic ADP-ribose-mediated Ca2+ signaling contributes to airway smooth muscle hyper-responsiveness. Adenosine Diphosphate 12-15 CD38 molecule Homo sapiens 0-4 24616605-8 2003 After ADP-stimulation an increase from 4.18+-1.02 to 5.69+-1.40 %PC in CD62P (p<0.01) and from 45.7+-3.4 to 57.9+-6.6 %PC in PAC1 (p<0.05) after TR were detected. Adenosine Diphosphate 6-9 selectin P Homo sapiens 71-76 12581630-6 2003 The extent of inhibition by MgADP on the motile activity of characean myosin was almost the same as in skeletal muscle or cardiac myosin. Adenosine Diphosphate 28-33 myosin heavy chain 14 Homo sapiens 70-76 12393417-5 2003 Interestingly, GPVI-mediated Rap1 activation in human platelets is largely dependent on adenosine diphosphate (ADP) signaling through the P2Y(12) and not the P2Y(1) receptor. Adenosine Diphosphate 88-109 glycoprotein VI platelet Homo sapiens 15-19 12393417-5 2003 Interestingly, GPVI-mediated Rap1 activation in human platelets is largely dependent on adenosine diphosphate (ADP) signaling through the P2Y(12) and not the P2Y(1) receptor. Adenosine Diphosphate 88-109 RAP1A, member of RAS oncogene family Homo sapiens 29-33 12393417-5 2003 Interestingly, GPVI-mediated Rap1 activation in human platelets is largely dependent on adenosine diphosphate (ADP) signaling through the P2Y(12) and not the P2Y(1) receptor. Adenosine Diphosphate 111-114 glycoprotein VI platelet Homo sapiens 15-19 12393417-5 2003 Interestingly, GPVI-mediated Rap1 activation in human platelets is largely dependent on adenosine diphosphate (ADP) signaling through the P2Y(12) and not the P2Y(1) receptor. Adenosine Diphosphate 111-114 RAP1A, member of RAS oncogene family Homo sapiens 29-33 12475993-11 2003 In contrast, overexpression of Mcl-1 proteins suppressed the ADP-ribosylation of the telomeric repeat binding factor 1, another tankyrase 1-interacting protein. Adenosine Diphosphate 61-64 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 31-36 12547721-8 2003 For CTs, ADP:ATP <1 correlates with Annexin V binding. Adenosine Diphosphate 9-12 annexin A5 Homo sapiens 39-48 12693968-4 2003 ReoPro and FRAMON completely inhibited ADP-induced release of soluble P-selectin from platelet alpha-granules, but did not influence P-selectin secretion stimulated by U46619 and by both thrombin concentrations. Adenosine Diphosphate 39-42 selectin P Homo sapiens 70-80 12632022-3 2003 These whole blood samples were also co-incubated with thrombin receptor activating peptide (TRAP) or adenosine diphosphate (ADP), to up-regulate P-selectin (CD62P) on platelets. Adenosine Diphosphate 101-122 selectin P Homo sapiens 145-155 28994403-2 2017 Previous X-ray crystallographic analyses of HSP70 have shown that HSP70 binds to ADP with internal water molecules. Adenosine Diphosphate 81-84 heat shock protein family A (Hsp70) member 4 Homo sapiens 44-49 28578011-6 2017 ADP binding amino acids within the nucleotide binding domain (NBD) of NOD1 were also predicted. Adenosine Diphosphate 0-3 nucleotide-binding oligomerization domain-containing protein 1 Oryctolagus cuniculus 70-74 29090276-1 2017 BACKGROUND: Hexokinase and glucokinase enzymes are ubiquitously expressed and use ATP and ADP as substrates in mammalian systems and a variety of polyphosphate substrates and/or ATP in some eukaryotic and microbial systems. Adenosine Diphosphate 90-93 glucokinase Homo sapiens 27-38 29090276-5 2017 RESULTS: A novel mammalian glucokinase, highly responsive to hexametaphosphate (HMP) but not ATP or ADP as a phosphoryl donor is present in the nuclei of mammalian hepatocytes. Adenosine Diphosphate 100-103 glucokinase Homo sapiens 27-38 28754691-5 2017 By contrast, in the ADP-bound state, exemplified by the Escherichia coli Hsp70 DnaK, the interdomain linker is flexible. Adenosine Diphosphate 20-23 heat shock protein family A (Hsp70) member 4 Homo sapiens 73-78 12632022-3 2003 These whole blood samples were also co-incubated with thrombin receptor activating peptide (TRAP) or adenosine diphosphate (ADP), to up-regulate P-selectin (CD62P) on platelets. Adenosine Diphosphate 101-122 selectin P Homo sapiens 157-162 12632022-3 2003 These whole blood samples were also co-incubated with thrombin receptor activating peptide (TRAP) or adenosine diphosphate (ADP), to up-regulate P-selectin (CD62P) on platelets. Adenosine Diphosphate 124-127 selectin P Homo sapiens 145-155 12632022-3 2003 These whole blood samples were also co-incubated with thrombin receptor activating peptide (TRAP) or adenosine diphosphate (ADP), to up-regulate P-selectin (CD62P) on platelets. Adenosine Diphosphate 124-127 selectin P Homo sapiens 157-162 12632022-6 2003 Incubation of platelets with 3,5-DIPS also caused a decrease in ADP-induced up-regulation of P-selectin but failed to affect TRAP or no-activator-treated platelets. Adenosine Diphosphate 64-67 selectin P Homo sapiens 93-103 12761183-3 2003 The intensity of the third-order meridional reflection from myosin filaments (at 1/14.4 nm(-1)) increased promptly after the ADP release with a time constant smaller than 5 ms, which was similar to that of tension decline. Adenosine Diphosphate 125-128 myosin heavy chain 14 Homo sapiens 60-66 28754691-7 2017 To better understand the role of this region in Hsp70 allostery, we used molecular dynamics simulations to explore the conformational landscape of the interdomain linker in ADP-bound DnaK and supported our simulations by strategic experimental data. Adenosine Diphosphate 173-176 heat shock protein family A (Hsp70) member 4 Homo sapiens 48-53 28723898-3 2017 Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and intracellular FBP decrease. Adenosine Diphosphate 25-28 fructose-bisphosphatase 1 Homo sapiens 134-137 12761183-4 2003 The results show that ADP binding induces a conformational change of myosin in skeletal muscle fibers. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 69-75 28723898-3 2017 Here, we describe an AMP/ADP-independent mechanism that triggers AMPK activation by sensing the absence of fructose-1,6-bisphosphate (FBP), with AMPK being progressively activated as extracellular glucose and intracellular FBP decrease. Adenosine Diphosphate 25-28 fructose-bisphosphatase 1 Homo sapiens 223-226 12871507-5 2003 The alphaIIb/beta3-dependent part of platelet aggregation induced by RFY was mainly due to secreted ADP and thromboxane A2. Adenosine Diphosphate 100-103 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 13-18 28744459-4 2017 In this study, we utilized mechanistic enzymology techniques to show that despite comparable kcat and Km parameters found in the ATPase activity, human and E. coli Lon exhibit significantly different susceptibility to ADP inhibition. Adenosine Diphosphate 218-221 putative ATP-dependent Lon protease Escherichia coli 164-167 28744459-6 2017 The relatively low affinity of human Lon for ADP cannot be accounted for by reversibility in ATP hydrolysis, as a positional isotope exchange experiment demonstrated both E. coli Lon and human Lon catalyzed ATP hydrolysis irreversibly. Adenosine Diphosphate 45-48 putative ATP-dependent Lon protease Escherichia coli 179-182 28744459-7 2017 A limited tryptic digestion study however indicated that human and E. coli Lon bind to ADP differently. Adenosine Diphosphate 87-90 putative ATP-dependent Lon protease Escherichia coli 75-78 28487312-1 2017 Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. Adenosine Diphosphate 37-40 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 28505454-2 2017 Hsp70 consists of two domains, a nucleotide binding domain (NBD) and a substrate binding domain (SBD), each of which communicates via an allosteric mechanism such that the protein interconverts between two functional states, an ATP-bound open conformation and an ADP-bound closed conformation. Adenosine Diphosphate 263-266 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 12871512-6 2003 However, this aggregation is independent of Galphaq and TxA2 signaling in response to high LSA concentrations, but is dependent on ADP signaling through its receptor P2Y12, and therefore presumably Gi, regardless of the level of LSA used to activate the platelets. Adenosine Diphosphate 131-134 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 166-171 12623443-6 2003 The P2Y(1) receptor antagonist MRS 2179 (1.06 - 10.25 micro mol/l) blocked ADP-induced PSC (by 100%). Adenosine Diphosphate 75-78 purinergic receptor P2Y1 Homo sapiens 4-19 28377485-3 2017 Ectonucleoside triphosphate diphosphohydrolase-1 (CD39), an enzyme expressed on the plasmalemma of leukocytes and endothelial cells, suppresses platelet activation and leukocyte infiltration by phosphohydrolyzing ATP/ADP. Adenosine Diphosphate 217-220 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-48 28377485-3 2017 Ectonucleoside triphosphate diphosphohydrolase-1 (CD39), an enzyme expressed on the plasmalemma of leukocytes and endothelial cells, suppresses platelet activation and leukocyte infiltration by phosphohydrolyzing ATP/ADP. Adenosine Diphosphate 217-220 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 50-54 12444083-1 2003 Glutamate dehydrogenase (GDH) is regulated by both positive (leucine and ADP) and negative (GTP and ATP) allosteric factors. Adenosine Diphosphate 73-76 glutamate dehydrogenase 1 Homo sapiens 25-28 28319837-2 2017 On a molecular level, AD+P is associated with greater reductions in the protein kalirin, a guanine exchange factor which has also been linked to the psychotic disease, schizophrenia. Adenosine Diphosphate 22-26 kalirin, RhoGEF kinase Mus musculus 80-87 12525161-10 2003 Stopped-flow fluorometry indicates that monastrol inhibits ADP release by forming an Eg5-ADP-monastrol ternary complex. Adenosine Diphosphate 59-62 kinesin family member 11 Homo sapiens 85-88 28343356-4 2017 CD39 is the dominant vascular nucleotidase that facilitates adenosine generation via extracellular ATP/ADP-phosphohydrolysis. Adenosine Diphosphate 103-106 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 12525166-6 2003 We show that with bound ADP.vanadate, which mimics the transition state between ATP and hydrolysis products, or with the ATP analogues AMP-PNP or ADP.BeF(x)() the myosin filaments are substantially ordered at higher temperatures but are reversibly disordered by cooling. Adenosine Diphosphate 24-27 myosin heavy chain 14 Homo sapiens 163-169 28254816-2 2017 Treatment of platelets with ligands of RXR has been shown to inhibit platelet responses to ADP and thromboxane A2; however, the effects on responses to other platelet agonists and the underlying mechanism have not been fully characterized. Adenosine Diphosphate 91-94 retinoid X receptor alpha Homo sapiens 39-42 12543814-2 2003 Here, we show that Bcl-2 enhances the ADP/ATP exchange in proteoliposomes containing the purified adenine nucleotide translocase (ANT) in isolated mitochondria and mitoplasts, as well as in intact cells in which mitochondrial matrix ATP was monitored continuously using a specific luciferase-based assay system. Adenosine Diphosphate 38-41 solute carrier family 25 member 6 Homo sapiens 130-133 27554816-11 2017 In mouse studies, P2ry13 and P2ry14-purinergic receptors activated by adenosine 5-diphosphate and UDP-sugars, respectively-were upregulated after allergen challenge, notably in airway epithelial cells, eosinophils, and neutrophils. Adenosine Diphosphate 70-93 purinergic receptor P2Y, G-protein coupled, 14 Mus musculus 29-35 12543814-3 2003 Conversely, Bax, which displaces Bcl-2 from ANT in apoptotic cells, inhibits ADP/ATP exchange through a direct action on ANT. Adenosine Diphosphate 77-80 solute carrier family 25 member 6 Homo sapiens 44-47 12543814-3 2003 Conversely, Bax, which displaces Bcl-2 from ANT in apoptotic cells, inhibits ADP/ATP exchange through a direct action on ANT. Adenosine Diphosphate 77-80 solute carrier family 25 member 6 Homo sapiens 121-124 27965414-8 2017 These results demonstrate that very low levels of ADP-ribosylation, synthesized by either PARP1 or PARP2, are sufficient for XRCC1 recruitment following oxidative stress. Adenosine Diphosphate 50-53 X-ray repair cross complementing 1 Homo sapiens 125-130 12511957-7 2003 Receptor stimulation by apoA-I triggers the endocytosis of holo-HDL particles (protein plus lipid) by a mechanism that depends strictly on the generation of ADP. Adenosine Diphosphate 157-160 apolipoprotein A1 Rattus norvegicus 24-30 28650323-8 2017 PLB (25 and 50mg/kg) remarkably reduced the ADP-induced PLC beta3 phosphorylation but not Akt in platelets as compared with the control group. Adenosine Diphosphate 44-47 phospholipase C beta 3 Rattus norvegicus 56-65 12930095-1 2003 The synthesis of ATP from ADP and inorganic phosphate by F1F0-ATP synthase, the universal enzyme in biological energy conversion, using the energy of a transmembrane gradient of ions, and the use of ATP by the myosin-actin system to cause muscular contraction are among the most fundamental processes in biology. Adenosine Diphosphate 26-29 myosin heavy chain 14 Homo sapiens 210-216 28002403-3 2017 Cells from a patient with mutations in XRCC1 exhibited not only reduced rates of single-strand break repair but also elevated levels of protein ADP-ribosylation. Adenosine Diphosphate 144-147 X-ray repair cross complementing 1 Homo sapiens 39-44 28002403-5 2017 Indeed, remarkably, genetic deletion of Parp1 rescued normal cerebellar ADP-ribose levels and reduced the loss of cerebellar neurons and ataxia in Xrcc1-defective mice, identifying a molecular mechanism by which endogenous single-strand breaks trigger neuropathology. Adenosine Diphosphate 72-75 poly (ADP-ribose) polymerase family, member 1 Mus musculus 40-45 12524316-0 2003 The 2"-O- and 3"-O-Cy3-EDA-ATP(ADP) complexes with myosin subfragment-1 are spectroscopically distinct. Adenosine Diphosphate 31-34 myosin heavy chain 14 Homo sapiens 51-57 28180001-9 2016 Both TRAP- and ADP-induced aggregation values were significantly lower immediately after tirofiban termination, than after 24 h [TRAP: 26.41 +- 25.00 units (U) vs. 109.86 +- 23.69 U, p < 0.0001; ADP: 17.43 +- 10.10 U vs. 43.92 +- 23.35 U, p <= 0.0001]. Adenosine Diphosphate 15-18 TRAP Homo sapiens 129-133 28180001-9 2016 Both TRAP- and ADP-induced aggregation values were significantly lower immediately after tirofiban termination, than after 24 h [TRAP: 26.41 +- 25.00 units (U) vs. 109.86 +- 23.69 U, p < 0.0001; ADP: 17.43 +- 10.10 U vs. 43.92 +- 23.35 U, p <= 0.0001]. Adenosine Diphosphate 198-201 TRAP Homo sapiens 5-9 12524316-1 2003 Ribose-modified highly-fluorescent sulfoindocyanine ATP and ADP analogs, 2"(3")-O-Cy3-EDA-AT(D)P, with kinetics similar to AT(D)P, enable myosin and actomyosin ATPase enzymology with single substrate molecules. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 138-144 27728892-8 2016 CYP2C19 genotyping: carriers of CYP2C19 loss-of-function alleles, HR: 2.515, 95% confidence interval (CI), 1.150-5.501, P=0.021; ADP-induced platelet inhibition <=30%, HR: 1.992, 95% CI, 1.040-3.818, P=0.038. Adenosine Diphosphate 129-132 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 27419376-11 2016 In line with this uptake of C3bot into vimentin KO neurons was strongly decreased resulting in reduced ADP-ribosylation of RhoA and B as detected by an antibody recognizing selectively ADP-ribosylated RhoA/B. Adenosine Diphosphate 103-106 vimentin Mus musculus 39-47 27422820-11 2016 These results highlight an antiplatelet strategy centered on blocking or desensitizing 5-HT2AR to attenuate ADP-mediated alphaIIbbeta3 activation. Adenosine Diphosphate 108-111 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 87-94 12525866-3 2003 It has been shown that the high apparent K(m) for exogenous ADP (250-350 mM) in permeabilized cells and in ghost cells (without myosin) and fibres (diameter 15-20 mm) is independent of intrinsic MgATPase activity. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 128-134 27474739-3 2016 Members of the BAG family of co-chaperones, including Bag1 and Bag3, are known to accelerate release of both ADP and client from Hsc70. Adenosine Diphosphate 109-112 heat shock protein family A (Hsp70) member 8 Homo sapiens 129-134 12871553-4 2003 Moreover, overexpression of the P2Y1 receptor enabled ADP to induce granule secretion, unlike in WT platelets, which suggests that the level of P2Y1 expression is critical for this event. Adenosine Diphosphate 54-57 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 32-45 27424653-8 2016 RESULTS: Psm2 dose-dependently inhibited human platelet aggregation induced by ADP, U4619, thrombin and collagen with IC50 values of 0.64, 0.37, 0.35 and 0.87 mg/mL, respectively. Adenosine Diphosphate 79-82 activating transcription factor 7 interacting protein 2 Mus musculus 9-13 27424653-9 2016 Psm2 (1, 3, 10 mg/kg) administered to rats significantly inhibited platelet aggregation ex vivo induced by ADP. Adenosine Diphosphate 107-110 activating transcription factor 7 interacting protein 2 Mus musculus 0-4 12871553-4 2003 Moreover, overexpression of the P2Y1 receptor enabled ADP to induce granule secretion, unlike in WT platelets, which suggests that the level of P2Y1 expression is critical for this event. Adenosine Diphosphate 54-57 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 32-36 12871553-5 2003 Our results further suggest that the weak responses of normal platelets to ADP are due to a limited number of P2Y1 receptors rather than to activation of a specific transduction pathway. Adenosine Diphosphate 75-78 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 110-114 27297888-6 2016 Homotypic and heterotypic (platelet-neutrophil) aggregation triggered by Adenosine DiPhosphate (ADP) and IL-1 or lipopolysaccharide (LPS) was increased in IL-1R8-deficient platelets. Adenosine Diphosphate 73-94 interleukin 1 receptor accessory protein-like 1 Mus musculus 155-161 12488509-5 2002 This demonstrates that ADP-ribosylation of HNP-1 occurs in vivo. Adenosine Diphosphate 23-26 HNP1 Homo sapiens 43-48 27297888-6 2016 Homotypic and heterotypic (platelet-neutrophil) aggregation triggered by Adenosine DiPhosphate (ADP) and IL-1 or lipopolysaccharide (LPS) was increased in IL-1R8-deficient platelets. Adenosine Diphosphate 96-99 interleukin 1 receptor accessory protein-like 1 Mus musculus 155-161 27297888-9 2016 In a mouse model of platelet-dependent pulmonary thromboembolism induced by ADP administration, IL-1R8-deficient mice showed an increased frequency of blood vessel complete obstruction. Adenosine Diphosphate 76-79 interleukin 1 receptor accessory protein-like 1 Mus musculus 96-102 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 8-11 N-myc downstream regulated 1 Homo sapiens 86-91 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 8-11 mono-ADP ribosylhydrolase 2 Homo sapiens 105-112 12438395-2 2002 Using a site-specific mutant in the SpvB active site, we verify that the ADP-ribosylation activity of SpvB is required for delayed cytotoxicity in human macrophages infected with Salmonella: SipB and the type III protein secretion system (TTSS) encoded by Salmonella pathogenicity island 1 (SPI1) are not involved, whereas the SPI2 TTSS is absolutely required for SpvB-dependent cytotoxicity. Adenosine Diphosphate 73-76 Salmonella plasmid virulence protein B Salmonella enterica subsp. enterica serovar Typhimurium 36-40 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 N-myc downstream regulated 1 Homo sapiens 86-91 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 mono-ADP ribosylhydrolase 2 Homo sapiens 105-112 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 N-myc downstream regulated 1 Homo sapiens 86-91 27406238-3 2016 Protein ADP-ribosylation can be reversed by the macrodomain-containing proteins PARG, TARG1, MacroD1 and MacroD2, which hydrolyse the ester bond known to link proteins to ADP-ribose as well as consecutive ADP-ribose subunits; targeting this bond can thus result in the complete removal of the protein modification or the conversion of poly(ADP-ribose) to mono(ADP-ribose). Adenosine Diphosphate 171-174 mono-ADP ribosylhydrolase 2 Homo sapiens 105-112 27406238-4 2016 Recently, proteins containing the NUDIX domain - namely human NUDT16 and bacterial RppH - have been shown to process in vitro protein ADP-ribosylation through an alternative mechanism, converting it into protein-conjugated ribose-5"-phosphate (R5P, also known as pR). Adenosine Diphosphate 134-137 nudix hydrolase 16 Homo sapiens 62-68 12438395-2 2002 Using a site-specific mutant in the SpvB active site, we verify that the ADP-ribosylation activity of SpvB is required for delayed cytotoxicity in human macrophages infected with Salmonella: SipB and the type III protein secretion system (TTSS) encoded by Salmonella pathogenicity island 1 (SPI1) are not involved, whereas the SPI2 TTSS is absolutely required for SpvB-dependent cytotoxicity. Adenosine Diphosphate 73-76 Salmonella plasmid virulence protein B Salmonella enterica subsp. enterica serovar Typhimurium 102-106 12438395-2 2002 Using a site-specific mutant in the SpvB active site, we verify that the ADP-ribosylation activity of SpvB is required for delayed cytotoxicity in human macrophages infected with Salmonella: SipB and the type III protein secretion system (TTSS) encoded by Salmonella pathogenicity island 1 (SPI1) are not involved, whereas the SPI2 TTSS is absolutely required for SpvB-dependent cytotoxicity. Adenosine Diphosphate 73-76 Salmonella plasmid virulence protein B Salmonella enterica subsp. enterica serovar Typhimurium 102-106 12149099-2 2002 We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) binding. Adenosine Diphosphate 118-121 solute carrier family 25 member 6 Homo sapiens 101-104 12149099-10 2002 This cross-linking stabilizes the "c" conformation of the ANT, reducing the reactivity of Cys(57), while enhancing CyP-D binding to the ANT and antagonizing ADP binding. Adenosine Diphosphate 157-160 solute carrier family 25 member 6 Homo sapiens 58-61 12161444-5 2002 This is accomplished by stimulating the conversion of hsp70-ATP to hsp70-ADP, the hsp70 conformation favored for Hop binding. Adenosine Diphosphate 73-76 stress induced phosphoprotein 1 Homo sapiens 113-116 12234494-1 2002 Soluble human CD39 (solCD39) rapidly metabolizes nucleotides, especially ADP released from activated platelets, thereby inhibiting further platelet activation and recruitment. Adenosine Diphosphate 73-76 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 14-18 12359072-3 2002 We have previously demonstrated that, in the presence of ADP, myosin forms stable ternary complexes with new phosphate analogues of aluminum fluoride (AlF(4)(-)) and beryllium fluoride (BeF(n)), and these stable complexes mimic the transient state along the ATPase kinetic pathway [Maruta et al. Adenosine Diphosphate 57-60 myosin heavy chain 14 Homo sapiens 62-68 12231375-9 2002 The energetic charge (EC = [(0.5 adenosine diphosphate + adenosine triphosphate) / (adenosine triphosphate + adenosine diphosphate + adenosine monophosphate)]) in STH-2, UW, HTK, STF, EC, and saline groups was significantly lower (p < 0.05) than in the other groups. Adenosine Diphosphate 109-130 sulfotransferase family 2A member 1 Rattus norvegicus 163-168 12187107-1 2002 It has been demonstrated in anti-Thy1 glomerulonephritis that extracellular adenine nucleotides have a significant pro-inflammatory activity, however, glomerular ATP/ADPase, which in concert with 5"-nucleotidase converts ATP/ADP, and AMP to anti-inflammatory adenosine had an anti-inflammatory role. Adenosine Diphosphate 166-169 Thy-1 cell surface antigen Homo sapiens 33-37 12148104-5 2002 Platelet reactivity was defined with respect to capacity to bind fibrinogen (activation of glycoprotein IIb-IIIa) and expression of P-selectin in response to adenosine diphosphate (ADP; 0, 0.2, and 1.0 micromol/L). Adenosine Diphosphate 158-179 selectin P Homo sapiens 132-142 12148104-5 2002 Platelet reactivity was defined with respect to capacity to bind fibrinogen (activation of glycoprotein IIb-IIIa) and expression of P-selectin in response to adenosine diphosphate (ADP; 0, 0.2, and 1.0 micromol/L). Adenosine Diphosphate 181-184 selectin P Homo sapiens 132-142 12148104-8 2002 Despite this effect, surface expression of P-selectin in response to 1 micromol/L of ADP was lower at the end of the dialysis session (arterial blood at its onset, 40% +/- 16%; arterial blood at its conclusion, 24% +/- 15%; P < 0.05). Adenosine Diphosphate 85-88 selectin P Homo sapiens 43-53 12210143-6 2002 The reconstitution study revealed that a small amount of adenosine diphosphate (ADP) from erythrocytes may play an important role in epinephrine-induced platelet aggregation (in whole blood), through mediation of P2Y1 receptors. Adenosine Diphosphate 57-78 purinergic receptor P2Y1 Homo sapiens 213-217 12210143-6 2002 The reconstitution study revealed that a small amount of adenosine diphosphate (ADP) from erythrocytes may play an important role in epinephrine-induced platelet aggregation (in whole blood), through mediation of P2Y1 receptors. Adenosine Diphosphate 80-83 purinergic receptor P2Y1 Homo sapiens 213-217 12022886-1 2002 The adenine binding domain of the ADP site within human glutamate dehydrogenase (GDH) was identified by cassette mutagenesis at the Tyr187 position. Adenosine Diphosphate 34-37 glutamate dehydrogenase 1 Homo sapiens 56-79 12022886-1 2002 The adenine binding domain of the ADP site within human glutamate dehydrogenase (GDH) was identified by cassette mutagenesis at the Tyr187 position. Adenosine Diphosphate 34-37 glutamate dehydrogenase 1 Homo sapiens 81-84 12022886-2 2002 The wild type GDH was activated 3-fold by ADP at a concentration of 1 mM at pH 8.0, whereas no significant activation by ADP was observed with the Tyr187 mutant GDH regardless of the size, hydrophobicity, and ionization of the side chains. Adenosine Diphosphate 42-45 glutamate dehydrogenase 1 Homo sapiens 14-17 12022886-4 2002 The binding of ADP to the wild type or mutant GDH was further examined by photoaffinity labeling with [alpha-(32)P]8-azidoadenosine 5"-diphosphate (8N(3)ADP). Adenosine Diphosphate 15-18 glutamate dehydrogenase 1 Homo sapiens 46-49 12022886-5 2002 8N(3)ADP, without photolysis, mimicked the stimulatory properties of ADP on GDH activity. Adenosine Diphosphate 5-8 glutamate dehydrogenase 1 Homo sapiens 76-79 12022886-6 2002 Saturation of photoinsertion with 8N(3)ADP occurred with apparent K(d) values near 25 microM for the wild type GDH, and the photoinsertion of [alpha-(32)P]8N(3)ADP was decreased best by ADP in comparison to other nucleotides. Adenosine Diphosphate 39-42 glutamate dehydrogenase 1 Homo sapiens 111-114 12022886-8 2002 For the wild type GDH, photolabel-containing peptide generated by tryptic digestion was identified in the region containing the sequence EMSWIADTYASTIG, and the photolabeling of this peptide was prevented >95% by the presence of 1 mM ADP during photolysis, whereas no such a peptide was detected for the Tyr187 mutant GDH in the presence or absence of ADP. Adenosine Diphosphate 237-240 glutamate dehydrogenase 1 Homo sapiens 18-21 27431926-6 2016 Furthermore, prior to ADP activation, the expression levels of CD62p, PAC-1 and CD42b in the ITP group were lower in ITP group than those in the normal control and ITP-CR groups. Adenosine Diphosphate 22-25 glycoprotein Ib platelet subunit alpha Homo sapiens 80-85 11815620-6 2002 Pharmacological blockade of the P2Y1 receptor totally prevented ADP-induced Ca(2+) mobilization but did not affect activation of Rap1B. Adenosine Diphosphate 64-67 purinergic receptor P2Y1 Homo sapiens 32-45 11914091-0 2002 Pathway of ADP-stimulated ADP release and dissociation of tethered kinesin from microtubules. Adenosine Diphosphate 11-14 Kinesin light chain Drosophila melanogaster 67-74 11914091-2 2002 Kinesin binds to microtubules with half-site ADP release to form a tethered intermediate with one attached head without nucleotide and one tethered head that retains its bound ADP. Adenosine Diphosphate 45-48 Kinesin light chain Drosophila melanogaster 0-7 11914091-2 2002 Kinesin binds to microtubules with half-site ADP release to form a tethered intermediate with one attached head without nucleotide and one tethered head that retains its bound ADP. Adenosine Diphosphate 176-179 Kinesin light chain Drosophila melanogaster 0-7 11914091-3 2002 For DKH405 containing amino acid residues 1-405 of Drosophila kinesin, release of the remaining ADP from the tethered head is slow (0.05 s(-1)), but release is accelerated by added ADP or ATP. Adenosine Diphosphate 96-99 Kinesin light chain Drosophila melanogaster 62-69 11914091-3 2002 For DKH405 containing amino acid residues 1-405 of Drosophila kinesin, release of the remaining ADP from the tethered head is slow (0.05 s(-1)), but release is accelerated by added ADP or ATP. Adenosine Diphosphate 181-184 Kinesin light chain Drosophila melanogaster 62-69 11950711-11 2002 This suggested that P2Y(12) and P2Y(1) were both involved in platelet adhesion on immobilized fibrinogen, thereby revealing it as ADP dependent. Adenosine Diphosphate 130-133 purinergic receptor P2Y1 Homo sapiens 32-38 11903050-5 2002 In order to determine the effects of these mutations on the function of the human GDH homohexamer, we studied the expression, purification and characterization of two of these regulatory mutations (H454Y, which affects the putative GTP-binding site, and S448P, which affects the antenna region) and a mutation designed to alter the putative binding site for ADP (R463A). Adenosine Diphosphate 358-361 glutamate dehydrogenase 1 Homo sapiens 82-85 11903050-8 2002 Conversely, the R463A mutation completely eliminated ADP activation of human GDH, but had little effect on either GTP inhibition or leucine activation. Adenosine Diphosphate 53-56 glutamate dehydrogenase 1 Homo sapiens 77-80 11903050-9 2002 The effects of these three mutations on ATP regulation indicated that this nucleotide inhibits human GDH through binding of its triphosphate tail to the GTP site and, at higher concentrations, activates the enzyme through binding of the nucleotide to the ADP site. Adenosine Diphosphate 255-258 glutamate dehydrogenase 1 Homo sapiens 101-104 11903050-10 2002 These data confirm the assignment of the GTP and ADP allosteric regulatory sites on GDH based on X-ray crystallography and provide insight into the structural mechanisms involved in positive and negative allosteric control and in inter-subunit co-operativity of human GDH. Adenosine Diphosphate 49-52 glutamate dehydrogenase 1 Homo sapiens 84-87 11903050-10 2002 These data confirm the assignment of the GTP and ADP allosteric regulatory sites on GDH based on X-ray crystallography and provide insight into the structural mechanisms involved in positive and negative allosteric control and in inter-subunit co-operativity of human GDH. Adenosine Diphosphate 49-52 glutamate dehydrogenase 1 Homo sapiens 268-271 11895784-1 2002 CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic calcium. Adenosine Diphosphate 72-93 CD38 molecule Homo sapiens 0-4 11959804-12 2002 In contrast, the P2Y(1) receptor is known to be obligatory in the process of ADP-induced platelet aggregation, and MRS2279 competitively inhibited ADP-promoted platelet aggregation with an apparent affinity (pK(B)=8.05) similar to that observed at the human P2Y(1) receptor heterologously expressed in 1321N1 cells. Adenosine Diphosphate 77-80 purinergic receptor P2Y1 Homo sapiens 17-32 11959804-12 2002 In contrast, the P2Y(1) receptor is known to be obligatory in the process of ADP-induced platelet aggregation, and MRS2279 competitively inhibited ADP-promoted platelet aggregation with an apparent affinity (pK(B)=8.05) similar to that observed at the human P2Y(1) receptor heterologously expressed in 1321N1 cells. Adenosine Diphosphate 147-150 purinergic receptor P2Y1 Homo sapiens 258-273 11985546-2 2002 The present review focuses on the adenine nucleotide translocator (ANT), which facilitates exchange of cytosolic ADP for mitochondrial ATP. Adenosine Diphosphate 113-116 solute carrier family 25 member 6 Homo sapiens 67-70 11985546-13 2002 Maladaptive hearts exhibiting ANT deficits demonstrate ADP-dependent respiratory kinetics similar to the newborn heart. Adenosine Diphosphate 55-58 solute carrier family 25 member 6 Homo sapiens 30-33 11904526-3 2002 Adenosine diphosphate (ADP)-induced expression of P-selectin and of PAC-1 was significantly reduced after 2 wk of clopidogrel but not of ASA treatment. Adenosine Diphosphate 0-21 selectin P Homo sapiens 50-60 11904526-3 2002 Adenosine diphosphate (ADP)-induced expression of P-selectin and of PAC-1 was significantly reduced after 2 wk of clopidogrel but not of ASA treatment. Adenosine Diphosphate 23-26 selectin P Homo sapiens 50-60 11956240-2 2002 Recombinant soluble human CD39 (solCD39) potently inhibited ex vivo platelet aggregation in response to ADP and reduced cerebral infarct volumes in mice following transient middle cerebral artery occlusion, even when given 3 hours after stroke. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 26-30 11854441-6 2002 Among several nucleotide agonists, ADP, AMP, and adenosine-5"-O-(3-thio)triphosphate induced the CFTR current. Adenosine Diphosphate 35-38 cystic fibrosis transmembrane conductance regulator L homeolog Xenopus laevis 97-101 11753011-8 2002 Surface expression of CD62P on ADP- and TRAP-6-stimulated platelets were significantly reduced after 1 and 2 MAC halothane. Adenosine Diphosphate 31-34 selectin P Homo sapiens 22-27 11753011-11 2002 Two MAC isoflurane led to an increase of the percentage of platelets expressing CD62P in the unstimulated and TRAP-6 stimulated samples, and of the amount of CD62P epitopes on the surface of platelets in the ADP-stimulated samples. Adenosine Diphosphate 208-211 selectin P Homo sapiens 158-163 12454370-12 2002 A10-bound platelets could still be activated by ADP or thrombin suggesting that this human scFv may represent an original anti-platelet agent for the treatment of collagen-mediated thrombotic diseases. Adenosine Diphosphate 48-51 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 0-3 11841696-8 2002 Furthermore, flow cytometry demonstrated that the platelet fraction expressed P-selectin and an activation motif on GPIIb/IIIa recognized by monoclonal antibody PAC-1 upon stimulation with adenosine diphosphate (ADP). Adenosine Diphosphate 189-210 selectin P Homo sapiens 78-88 27334455-5 2016 In this work, we built two models named "the ADP model" and "the ATP model", where ADP and ATP are bound to AAA1 in the AAA(+) ring, respectively, to observe the initial procedure of the structural change from the unprimed to the primed state. Adenosine Diphosphate 83-86 AAA1 Homo sapiens 108-112 27131790-2 2016 Our published work has demonstrated a dual function of the SWI5-SFR1 complex in RAD51-mediated DNA strand exchange, namely, by stabilizing the presynaptic filament and maintaining the catalytically active ATP-bound state of the filament via enhancement of ADP release. Adenosine Diphosphate 256-259 RAD51 recombinase Homo sapiens 80-85 11841696-8 2002 Furthermore, flow cytometry demonstrated that the platelet fraction expressed P-selectin and an activation motif on GPIIb/IIIa recognized by monoclonal antibody PAC-1 upon stimulation with adenosine diphosphate (ADP). Adenosine Diphosphate 212-215 selectin P Homo sapiens 78-88 11747450-6 2001 The posthydrolytic (Mg-ADP-V(i) bound) form of P-gp also exhibited low-affinity substrate binding (K(d) = 446 +/- 57 nM). Adenosine Diphosphate 20-26 phosphoglycolate phosphatase Homo sapiens 47-51 27208163-2 2016 Even less is known about the potential role that alterations in CD39 (ENTPD1), the ectonucleotidase responsible for the conversion of the nucleotides ATP and ADP to AMP, may play in pulmonary arterial hypertension. Adenosine Diphosphate 158-161 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 64-68 27208163-2 2016 Even less is known about the potential role that alterations in CD39 (ENTPD1), the ectonucleotidase responsible for the conversion of the nucleotides ATP and ADP to AMP, may play in pulmonary arterial hypertension. Adenosine Diphosphate 158-161 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 70-76 11746417-7 2001 The allosteric activators ADP (0.1-1.0 mM) and L-leucine (1.0-10.0 mM) induce a concentration-dependent enzyme stimulation that is proportionally greater for the nerve tissue-specific GDH (up to 1,600%) than for the housekeeping enzyme (up to 150%). Adenosine Diphosphate 26-29 glutamate dehydrogenase 1 Homo sapiens 184-187 26865365-8 2016 ATP hydrolysis and adenosine diphosphate (ADP)/ATP exchange are key events for substrate binding and Hsp70 release during folding of nascent polypeptides. Adenosine Diphosphate 19-40 heat shock protein family A (Hsp70) member 4 Homo sapiens 101-106 26865365-8 2016 ATP hydrolysis and adenosine diphosphate (ADP)/ATP exchange are key events for substrate binding and Hsp70 release during folding of nascent polypeptides. Adenosine Diphosphate 42-45 heat shock protein family A (Hsp70) member 4 Homo sapiens 101-106 11746417-8 2001 When used together at lower concentrations, ADP (10-50 mM) and L-leucine (75-200 microM) act synergistically in stimulating GDH activity. Adenosine Diphosphate 44-47 glutamate dehydrogenase 1 Homo sapiens 124-127 26660522-1 2016 Adenosine diphosphate directly induces platelet aggregation via the G-protein coupled P2Y1 and P2Y12 receptors. Adenosine Diphosphate 0-21 P2Y purinoceptor 12 Macaca fascicularis 95-100 11746417-10 2001 Thus, although the housekeeping GDH is regulated primarily by GTP, the nerve tissue GDH activity depends largely on available ADP or L-leucine levels. Adenosine Diphosphate 126-129 glutamate dehydrogenase 1 Homo sapiens 84-87 26743169-4 2016 In vivo treatment with GLS-409 significantly inhibited adenosine diphosphate- and collagen-stimulated platelet aggregation in rats. Adenosine Diphosphate 55-76 glutaminase 2 Rattus norvegicus 23-26 11746417-11 2001 Conditions associated with enhanced hydrolysis of ATP to ADP (e.g., intense glutamatergic transmission) are likely to activate nerve tissue-specific GDH leading to an increased glutamate flux through this pathway. Adenosine Diphosphate 57-60 glutamate dehydrogenase 1 Homo sapiens 149-152 26555263-2 2016 ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases. Adenosine Diphosphate 0-3 ADP dependent glucokinase Homo sapiens 27-32 11723245-5 2001 Moreover, 2-methylthioadenosine-5"-triphosphate and 2-methylthioadenosine-5"-diphosphate were 58- and 75-fold more potent than ATP and ADP, respectively, at the cP2Y11 receptor compared with only 2- to 3-fold more potent at the hP2Y11 receptor. Adenosine Diphosphate 135-138 purinergic receptor P2Y11 Homo sapiens 228-234 27143114-2 2016 For this purpose, hG6PD was initially purified 557-fold at a yield of 51.43% using 2",5"-adenosine diphosphate (ADP) sepharose 4B affinity gel chromatography. Adenosine Diphosphate 112-115 glucose-6-phosphate dehydrogenase Homo sapiens 18-23 11672756-8 2001 In the presence of P2Y(1) antagonist adenosine 3",5"-diphosphosulfate (A3P5PS), ADP failed to induce platelet aggregation in NR (7.8+/-4.7% vs. 64.7+/-11.2% in R, P<.01). Adenosine Diphosphate 80-83 purinergic receptor P2Y1 Homo sapiens 19-25 11595779-5 2001 RESULTS: Our results show that patients with the leptin gene mutation (both the homozygous and heterozygous patients) had significantly higher ADP-induced (78.3 +/- 3.4% vs. 57.9 +/- 9.3%, p = 0.001), collagen-induced (78.1 +/- 2.9% vs. 56.7 +/- 9.3%, p = 0.007), and epinephrine-induced (76.5 +/- 9.2% vs. 59.5 +/- 7.70%, p = 0.003) platelet aggregation compared with controls. Adenosine Diphosphate 143-146 leptin Homo sapiens 49-55 27316994-3 2016 Using Alk2 as an example, we present two protocols - one based on phosphate-binding Alphascreen beads, the other on coupled luminescence measurements of ADP formation - that can be used to screen for inhibitors of autophosphorylation. Adenosine Diphosphate 153-156 activin A receptor type 1 Homo sapiens 6-10 27028818-8 2016 According to the data obtained by Western blot, upon the cell activation with ADP, the number of GP IIb-IIIa and P2Y12 receptors increases, which may serve as evidence of these proteins being synthesized in the activated platelets. Adenosine Diphosphate 78-81 integrin subunit alpha 2b Homo sapiens 97-103 26434503-11 2015 These data suggest that PKC limits ADP-evoked rises in [Ca(2+)]cyt by acceleration of SERCA activity, whilst rises in [Ca(2+)]cyt evoked by the stronger platelet activator thrombin are limited by PKC through acceleration of both SERCA and Na(+)/K(+)-ATPase activity, with the latter limiting the effect of thrombin on rises in [Na(+)]cyt and so forward mode NCX activity. Adenosine Diphosphate 35-38 T cell leukemia homeobox 2 Homo sapiens 358-361 11448949-3 2001 Using a classic ARF activation assay, the cholera toxin-catalyzed ADP-ribosylation of G alpha(s), results show that LH/CG R activation stimulates an ARF protein by a brefeldin A-independent mechanism. Adenosine Diphosphate 66-69 luteinizing hormone/choriogonadotropin receptor Homo sapiens 116-123 26395809-4 2015 Cardiac-specific genes showed enhanced expression of alpha-MHC, MLC2v, alpha-actinin, connexin 45 (Cx45), and HCN4, on both gene and protein levels upon ADP/ATP treatment, indicating increased cardiomyogenesis and pacemaker cell differentiation. Adenosine Diphosphate 153-156 myosin, light polypeptide 2, regulatory, cardiac, slow Mus musculus 64-69 26395809-4 2015 Cardiac-specific genes showed enhanced expression of alpha-MHC, MLC2v, alpha-actinin, connexin 45 (Cx45), and HCN4, on both gene and protein levels upon ADP/ATP treatment, indicating increased cardiomyogenesis and pacemaker cell differentiation. Adenosine Diphosphate 153-156 gap junction protein, gamma 1 Mus musculus 86-97 26395809-4 2015 Cardiac-specific genes showed enhanced expression of alpha-MHC, MLC2v, alpha-actinin, connexin 45 (Cx45), and HCN4, on both gene and protein levels upon ADP/ATP treatment, indicating increased cardiomyogenesis and pacemaker cell differentiation. Adenosine Diphosphate 153-156 gap junction protein, gamma 1 Mus musculus 99-103 11513738-4 2001 In the present study we wanted to test whether the CD38-cADPR complex is kinetically competent in the conversion of NAD(+) into the reaction product ADP-ribose. Adenosine Diphosphate 57-60 CD38 molecule Homo sapiens 51-55 26282717-9 2015 In washed human platelets, 100 nM riociguat reduced ADP-induced GPIIb/IIIa activation, while a 10-fold higher concentration was required to reduce convulxin-stimulated GPIIb/IIIa activation. Adenosine Diphosphate 52-55 integrin subunit alpha 2b Homo sapiens 64-69 11513738-6 2001 Analysis of the kinetic parameters measured for the CD38/NAD(+) glycohydrolase-catalysed hydrolysis of 2"-deoxy-2"-aminoribo-NAD(+) and ADP-cyclo[N1,C1"]-2"-deoxy-2"-aminoribose (slowly hydrolysable analogues of NAD(+) and cADPR respectively) ruled out that the CD38-cADPR complex can accumulate under steady-state conditions. Adenosine Diphosphate 136-139 CD38 molecule Homo sapiens 52-56 11441983-7 2001 An oxidant concentration-dependent decrease in the expression of P-selectin appeared (at 3 mM CT to 39, 23, and 20% of the 100% saline control level for ADP, collagen, and TRAP, respectively). Adenosine Diphosphate 153-156 selectin P Homo sapiens 65-75 26334261-4 2015 METHODS AND RESULTS: Using a platelet-specific gene knockout, we show that the absence of LARG results in a marked reduction in aggregation and dense-granule secretion in response to the thromboxane mimetic U46619 and proteinase-activated receptor 4-activating peptide, AYPGKF, but not to adenosine diphosphate. Adenosine Diphosphate 289-310 Rho guanine nucleotide exchange factor (GEF) 12 Mus musculus 90-94 11508269-10 2001 Evidence suggested that CD38 on B lymphocytes competes with ART2.2 for substrate needed by B lymphocytes for ADP ribosylation. Adenosine Diphosphate 109-112 ADP-ribosyltransferase 2b Mus musculus 60-66 26445448-5 2015 Loop L11, a component of the microtubule-motor interface and implicated in activating ADP release upon microtubule collision, is significantly extended in KIF3C as compared with other kinesins. Adenosine Diphosphate 86-89 immunoglobulin kappa variable 1-6 Homo sapiens 5-8 26445448-5 2015 Loop L11, a component of the microtubule-motor interface and implicated in activating ADP release upon microtubule collision, is significantly extended in KIF3C as compared with other kinesins. Adenosine Diphosphate 86-89 kinesin family member 3C Homo sapiens 155-160 11508269-11 2001 CONCLUSIONS: ART2.2 on T cells may not simply mark the resting state, but could also contribute to it via ADP-ribosylation. Adenosine Diphosphate 106-109 ADP-ribosyltransferase 2b Mus musculus 13-19 12650200-6 2001 Moreover, PARP-1 can control its protein and DNA interactions by catalyzing its automodification with poly(ADP-ribose) molecules that can include up to 200 ADP-ribose residues and several branching points; by these polymers, PARP-1 may nocovalently interact with other proteins and alter their functions. Adenosine Diphosphate 107-110 poly (ADP-ribose) polymerase 1 Rattus norvegicus 10-16 26130715-4 2015 We show that the phosphate-binding pocket in the central BRCT1 domain of XRCC1 is required for selective binding to poly (ADP-ribose) at low levels of ADP-ribosylation, and promotes interaction with cellular PARP1. Adenosine Diphosphate 122-125 X-ray repair cross complementing 1 Homo sapiens 73-78 12650200-6 2001 Moreover, PARP-1 can control its protein and DNA interactions by catalyzing its automodification with poly(ADP-ribose) molecules that can include up to 200 ADP-ribose residues and several branching points; by these polymers, PARP-1 may nocovalently interact with other proteins and alter their functions. Adenosine Diphosphate 107-110 poly (ADP-ribose) polymerase 1 Rattus norvegicus 225-231 26028562-4 2015 A high expression level of glucokinase enabled efficient glucose phosphorylation, increasing the ATP/ADP ratio along with stimulation of insulin secretion in the physiological glucose concentration range. Adenosine Diphosphate 101-104 glucokinase Homo sapiens 27-38 25947940-3 2015 We show here that Panx1 forms ATP release channels in human platelets and that inhibiting Panx1 channel function with probenecid, mefloquine or specific (10)Panx1 peptides reduces collagen-induced platelet aggregation but not the response induced by arachidonic acid or ADP. Adenosine Diphosphate 270-273 pannexin 1 Homo sapiens 90-95 25947940-3 2015 We show here that Panx1 forms ATP release channels in human platelets and that inhibiting Panx1 channel function with probenecid, mefloquine or specific (10)Panx1 peptides reduces collagen-induced platelet aggregation but not the response induced by arachidonic acid or ADP. Adenosine Diphosphate 270-273 pannexin 1 Homo sapiens 90-95 11301326-0 2001 ADP binding induces an asymmetry between the heads of unphosphorylated myosin. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 71-77 25912285-11 2015 Moreover, uncoupling of the GroEL rings and formation of symmetric GroEL:GroES2 complexes is suppressed at physiological ATP:ADP concentration. Adenosine Diphosphate 125-128 heat shock protein family D (Hsp60) member 1 Homo sapiens 28-33 25912285-11 2015 Moreover, uncoupling of the GroEL rings and formation of symmetric GroEL:GroES2 complexes is suppressed at physiological ATP:ADP concentration. Adenosine Diphosphate 125-128 heat shock protein family D (Hsp60) member 1 Homo sapiens 67-72 26058047-6 2015 ADP-induced platelet reactivity by all aggregation tests correlated significantly with ADP-induced P-selectin expression and activated GPIIb/IIIa (all p<0.001). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 135-140 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 87-90 integrin subunit alpha 2b Homo sapiens 61-66 11410739-8 2001 RESULTS: Incubation of rat liver homogenates in ADP-ribosylation reaction mixture resulted in a radiolabeling of a 116 kDa protein, most likely auto-ribosylation of PARP. Adenosine Diphosphate 48-51 poly (ADP-ribose) polymerase 1 Rattus norvegicus 165-169 26058047-8 2015 The platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP were significantly higher in patients with high on-treatment residual platelet reactivity (HRPR) to ADP by all test systems (all p<0.001). Adenosine Diphosphate 191-194 integrin subunit alpha 2b Homo sapiens 61-66 11413167-2 2001 ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 98-102 11413167-2 2001 ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 107-112 25789582-3 2015 In the present study, we show that human Nudix (nucleoside diphosphate-linked moiety X)-type motif 16 (hNUDT16) represents a new enzyme class that can process protein ADP-ribosylation in vitro, converting it into ribose-5"-phosphate (R5P) tags covalently attached to the modified proteins. Adenosine Diphosphate 167-170 nudix hydrolase 16 Homo sapiens 103-110 25789582-4 2015 Furthermore, our data show that hNUDT16 enzymatic activity can be used to trim ADP-ribosylation on proteins in order to facilitate analysis of ADP-ribosylation sites on proteins by MS. Adenosine Diphosphate 79-82 nudix hydrolase 16 Homo sapiens 32-39 11432937-3 2001 In this study a hexokinase activity is described that is inhibited by ADP (K(i)=30 microM) and mannoheptulose (K(i) congruent with 300 microM) in non-cytosolic fractions (mitochondria, Golgi apparatus and microsomes) obtained from preparations of seedling roots of maize (Zea mays L.). Adenosine Diphosphate 70-73 hexokinase 2 Zea mays 16-26 25839656-9 2015 Based on our data, we proposed that inhibition of UCP3 by ADP could contribute to the endogenous MMP observed in ccRCC and other cancer cells. Adenosine Diphosphate 58-61 uncoupling protein 3 Homo sapiens 50-54 11278618-5 2001 Although nucleotides are not absolutely required for DNA binding, ADP stimulated the binding of UL5-UL52 to single strand DNA whereas ATP, ADP, and adenosine 5"-O-(thiotriphosphate) stimulated the binding to a forked substrate. Adenosine Diphosphate 66-69 helicase-primase primase subunit Human alphaherpesvirus 1 100-104 25837792-7 2015 The inhibition effect of adenosine diphosphate also received a good performance in PNK inhibitor screening research, thereby providing a useful scheme for practical use in quantitative PNK activity assay for life science and biological research. Adenosine Diphosphate 25-46 polynucleotide kinase 3'-phosphatase Homo sapiens 83-86 25837792-7 2015 The inhibition effect of adenosine diphosphate also received a good performance in PNK inhibitor screening research, thereby providing a useful scheme for practical use in quantitative PNK activity assay for life science and biological research. Adenosine Diphosphate 25-46 polynucleotide kinase 3'-phosphatase Homo sapiens 185-188 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 75-78 Cgi121p Saccharomyces cerevisiae S288C 52-58 11350929-9 2001 GDH, a highly regulated enzyme, is the first mitochondrial protein identified whose activity may be modulated by ADP-ribosylation. Adenosine Diphosphate 113-116 glutamate dehydrogenase 1 Homo sapiens 0-3 25735745-3 2015 In the present work, the crystal structure of Bud32/Cgi121 in complex with ADP revealed that ADP is bound in the catalytic site of Bud32 in a canonical manner characteristic of Protein Kinase A (PKA) family proteins. Adenosine Diphosphate 93-96 Cgi121p Saccharomyces cerevisiae S288C 52-58 25550208-11 2015 Finally, ADP-induced platelet aggregation was attenuated by MM284, as well as by inhibiting paracrine-secreted CyPA without directly affecting Ca(2+)-signaling. Adenosine Diphosphate 9-12 peptidylprolyl isomerase A Mus musculus 111-115 11344082-0 2001 Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y(1) receptor on bone cells. Adenosine Diphosphate 14-17 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 85-100 25620203-7 2015 Cys268 and Glu373 residues of DDX58 belong to ATP-binding motifs I and II, respectively, and these residues are predicted to be located closer to the ADP and RNA molecules than other nonpathogenic missense variants by protein structure analysis. Adenosine Diphosphate 150-153 DExD/H-box helicase 58 Homo sapiens 30-35 11344082-7 2001 The ADP effects were blocked in a nontoxic manner by MRS 2179, a P2Y(1) receptor antagonist. Adenosine Diphosphate 4-7 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 65-80 11305926-5 2001 The fluorescent phosphorylated NDPK is used to measure the amount of ADP and the unphosphorylated to measure ATP. Adenosine Diphosphate 69-72 cytidine/uridine monophosphate kinase 2 Homo sapiens 31-35 25654504-4 2015 Additionally, an age-dependent accumulation of amyloid-beta1-40 peptide occurred in skeletal muscle of 3xTg-AD mice, an effect that preceded bioenergetics mitochondrial dysfunction, which was only detected at 12 months of age, characterized by decreased respiratory control ratio and ADP/O index and by an impairment of complex I activity. Adenosine Diphosphate 284-287 renin binding protein Mus musculus 17-20 11305926-6 2001 The labeled protein is phosphorylated to > 90%, and the resultant molecule is stable on ice or can be stored at -80 degrees C. The fluorescence responds to the fraction of protein phosphorylated and so to the equilibrium between ADP plus NDPK approximately P and ATP plus NDPK. Adenosine Diphosphate 232-235 cytidine/uridine monophosphate kinase 2 Homo sapiens 241-245 24878761-4 2015 Moreover, the macrodomain-containing proteins MacroD1, MacroD2, and TARG1/C6orf130 were recently described as hydrolases, which remove mono-ADP-ribosylation thus providing evidence that this modification is reversible. Adenosine Diphosphate 140-143 mono-ADP ribosylhydrolase 2 Homo sapiens 55-62 25318479-3 2015 Ectonucleoside triphosphate diphosphohydrolase 1, ENTPDase1 (CD39) is a cell surface nucleotide-metabolizing enzyme, which degrades the extracellular purines ATP and ADP, thereby regulating purinergic receptor signaling. Adenosine Diphosphate 166-169 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-48 25318479-3 2015 Ectonucleoside triphosphate diphosphohydrolase 1, ENTPDase1 (CD39) is a cell surface nucleotide-metabolizing enzyme, which degrades the extracellular purines ATP and ADP, thereby regulating purinergic receptor signaling. Adenosine Diphosphate 166-169 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 61-65 11305926-6 2001 The labeled protein is phosphorylated to > 90%, and the resultant molecule is stable on ice or can be stored at -80 degrees C. The fluorescence responds to the fraction of protein phosphorylated and so to the equilibrium between ADP plus NDPK approximately P and ATP plus NDPK. Adenosine Diphosphate 232-235 cytidine/uridine monophosphate kinase 2 Homo sapiens 275-279 11323002-5 2001 In vehicle-treated samples, soluble P-selectin levels in response to 1 microM ADP-induced primary aggregation were similar to those of circulating levels of healthy volunteers but the levels in response to 5 microM ADP-induced secondary aggregation and collagen-induced aggregation increased markedly compared to those in response to primary aggregation. Adenosine Diphosphate 78-81 selectin P Homo sapiens 36-46 25332845-1 2014 Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG). Adenosine Diphosphate 5-8 poly(ADP-ribose) glycohydrolase Chlorocebus sabaeus 132-162 25332845-1 2014 Poly-ADP-ribose (PAR) is a polymer of up to 400 ADP-ribose units synthesized by poly-ADP-ribose-polymerases (PARPs) and degraded by poly-ADP-ribose-glycohydrolase (PARG). Adenosine Diphosphate 5-8 poly(ADP-ribose) glycohydrolase Chlorocebus sabaeus 164-168 11323002-5 2001 In vehicle-treated samples, soluble P-selectin levels in response to 1 microM ADP-induced primary aggregation were similar to those of circulating levels of healthy volunteers but the levels in response to 5 microM ADP-induced secondary aggregation and collagen-induced aggregation increased markedly compared to those in response to primary aggregation. Adenosine Diphosphate 215-218 selectin P Homo sapiens 36-46 11342262-0 2001 A possible solvent effect of adenosine diphosphate influences the binding of 1,N6 ethenoadenosine diphosphate to myosin from skeletal muscle. Adenosine Diphosphate 29-50 myosin heavy chain 14 Homo sapiens 113-119 11342262-6 2001 To explain our finding we propose that MgADP operates a complex type of inhibition, acting both directly as a competitor for myosin active sites, and indirectly by perturbing the regions of the solvent near to the protein. Adenosine Diphosphate 39-44 myosin heavy chain 14 Homo sapiens 125-131 11527153-13 2001 Particles from SFV/PAI-1 infected cells display a 5-fold enhanced secretion of PAI-1 following treatment with ADP in comparison to particles incubated in the absence of secretagogue. Adenosine Diphosphate 110-113 serpin family E member 1 Homo sapiens 19-24 11527153-13 2001 Particles from SFV/PAI-1 infected cells display a 5-fold enhanced secretion of PAI-1 following treatment with ADP in comparison to particles incubated in the absence of secretagogue. Adenosine Diphosphate 110-113 serpin family E member 1 Homo sapiens 79-84 11077069-2 2001 The interaction between the 5-HT(1A) receptor and rat G(alphai3) protein was modulated by substitution of the G(alphai3) protein site for pertussis toxin-catalysed ADP-ribosylation (cysteine(351)) by each of the natural amino acids. Adenosine Diphosphate 164-167 5-hydroxytryptamine receptor 1A Homo sapiens 28-45 11209975-3 2000 Two purinergic receptors contribute separately to the complex process of ADP-induced platelet aggregation: the P2Y1 metabotropic receptor responsible for mobilization of ionized calcium from internal stores, which initiates aggregation, and P2Y receptor coupled to adenylyl cyclase inhibition, which is essential for the full aggregation response to ADP and stabilization of platelet aggregates. Adenosine Diphosphate 73-76 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 111-115 11209975-3 2000 Two purinergic receptors contribute separately to the complex process of ADP-induced platelet aggregation: the P2Y1 metabotropic receptor responsible for mobilization of ionized calcium from internal stores, which initiates aggregation, and P2Y receptor coupled to adenylyl cyclase inhibition, which is essential for the full aggregation response to ADP and stabilization of platelet aggregates. Adenosine Diphosphate 350-353 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 111-115 11122160-6 2000 Activation of GPIIb-IIIa, monitored with mAb PAC-1, was markedly decreased (< 20% of normal) in response to ADP, thrombin and platelet-activating factor (PAF); expression of ligand-induced binding sites (LIBS) was < or = 30% of normal. Adenosine Diphosphate 111-114 ADCYAP receptor type I Homo sapiens 45-50 11032875-8 2000 In contrast, GLUD2 GDH activated by ADP and/or L-leucine was amenable to this inhibition, although at substantially higher GTP concentrations than the GLUD1 enzyme. Adenosine Diphosphate 36-39 glutamate dehydrogenase 1 Homo sapiens 19-22 11032875-8 2000 In contrast, GLUD2 GDH activated by ADP and/or L-leucine was amenable to this inhibition, although at substantially higher GTP concentrations than the GLUD1 enzyme. Adenosine Diphosphate 36-39 glutamate dehydrogenase 1 Homo sapiens 151-156 11139946-7 2000 P-selectin expression was determined by flow cytometry (antibody binding capacity [BC]) at baseline and after platelet stimulation with adenosine diphosphate (ADP) and thrombin receptor activating peptide (TRAP). Adenosine Diphosphate 136-157 selectin P Homo sapiens 0-10 11139946-7 2000 P-selectin expression was determined by flow cytometry (antibody binding capacity [BC]) at baseline and after platelet stimulation with adenosine diphosphate (ADP) and thrombin receptor activating peptide (TRAP). Adenosine Diphosphate 159-162 selectin P Homo sapiens 0-10 11108903-6 2000 Platelet P-selectin expression was 1.1+/-0.3% and 39.6+/-13.7% in unfixed resting and 10(-5) M ADP stimulated samples, respectively. Adenosine Diphosphate 95-98 selectin P Homo sapiens 9-19 11108903-8 2000 Formaldehyde fixation caused small increases of P-selectin expression in ADP-stimulated samples. Adenosine Diphosphate 73-76 selectin P Homo sapiens 48-58 11011152-9 2000 The global shape of the complex was also studied using small angle X-ray solution scattering and compared it with other previously reported myosin.ADP. Adenosine Diphosphate 147-150 myosin heavy chain 14 Homo sapiens 140-146 11014639-2 2000 Nucleoside triphosphate diphosphohydrolase (NTPDase or CD39) is a vascular ectoenzyme that hydrolyses ATP and ADP; however, this activity is lost during reperfusion injury. Adenosine Diphosphate 110-113 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 55-59 11007486-5 2000 The measurements also show that bound Mg.ADP.Pi, and not bound Mg.ATP, induces the myosin to adopt the prestroke states. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 83-89 10987587-6 2000 Clopidogrel with or without aspirin significantly suppressed expression of platelet activation markers CD 62p, CD 63 and PAC-1 after stimulation with ADP or thrombin (p < 0.001). Adenosine Diphosphate 150-153 selectin P Homo sapiens 103-109 10987587-6 2000 Clopidogrel with or without aspirin significantly suppressed expression of platelet activation markers CD 62p, CD 63 and PAC-1 after stimulation with ADP or thrombin (p < 0.001). Adenosine Diphosphate 150-153 CD63 molecule Homo sapiens 111-116 25124039-6 2014 Subsequent biochemical studies on identified partner proteins showed that the mitochondrial ADP/ATP carrier associates with the membrane-embedded core of the TIM23 complex in a stoichiometric manner, revealing an unexpected connection of mitochondrial protein biogenesis to metabolite transport. Adenosine Diphosphate 92-95 translocase of inner mitochondrial membrane 23 Homo sapiens 158-163 10987587-6 2000 Clopidogrel with or without aspirin significantly suppressed expression of platelet activation markers CD 62p, CD 63 and PAC-1 after stimulation with ADP or thrombin (p < 0.001). Adenosine Diphosphate 150-153 ADCYAP receptor type I Homo sapiens 121-126 10963785-3 2000 Both hirutonin and the chimeric peptide significantly inhibited ADP-induced platelet activation as detected by CD62 expression. Adenosine Diphosphate 64-67 selectin P Homo sapiens 111-115 25066134-4 2014 Exchanging ADP in dimeric MCAK with ATP at the MT plus end induces outward curvature in alpha/beta-tubulin, accompanied by a restructuring of the MCAK neck and N terminus, as it returns to a closed state. Adenosine Diphosphate 11-14 kinesin family member 2C Homo sapiens 26-30 25066134-4 2014 Exchanging ADP in dimeric MCAK with ATP at the MT plus end induces outward curvature in alpha/beta-tubulin, accompanied by a restructuring of the MCAK neck and N terminus, as it returns to a closed state. Adenosine Diphosphate 11-14 kinesin family member 2C Homo sapiens 146-150 25066134-6 2014 Thus, full-length ADP-MCAK transitions from an open diffusion-competent configuration to a closed state upon plus end-mediated nucleotide exchange, which is mediated by conformational changes in the N-terminal domains of the dimer. Adenosine Diphosphate 18-21 kinesin family member 2C Homo sapiens 22-26 10970768-0 2000 The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets. Adenosine Diphosphate 44-47 purinergic receptor P2X 1 Homo sapiens 13-18 24336891-8 2014 Platelet surface expression of CX3CR1 was increased in CHF rats, who displayed an impaired response to clopidogrel (platelet reactivity to ADP: CHF 30 +- 22%; Sham: 8 +- 5%, p<0.05). Adenosine Diphosphate 139-142 C-X3-C motif chemokine receptor 1 Rattus norvegicus 31-37 24336898-5 2014 Both high MATHROMBIN(>= 68 mm) and CYP2C19*2 allele carriage were independently associated with ADP-induced platelet aggregation (beta coefficient: 8.3% and 12.0%, respectively). Adenosine Diphosphate 99-102 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 38-45 10970768-2 2000 Desensitization of the P(2X1)receptor with the selective agonist, alphabeta-methylene ATP, reduced the integral of the ADP-evoked rise in [Ca(2+)](i)to about 90% of control; a reduction equivalent to the integral of the P(2X1)-evoked response alone. Adenosine Diphosphate 119-122 purinergic receptor P2X 1 Homo sapiens 23-37 24508339-0 2014 The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Adenosine Diphosphate 50-53 mitochondrial elongation factor 1 Homo sapiens 35-40 10970768-2 2000 Desensitization of the P(2X1)receptor with the selective agonist, alphabeta-methylene ATP, reduced the integral of the ADP-evoked rise in [Ca(2+)](i)to about 90% of control; a reduction equivalent to the integral of the P(2X1)-evoked response alone. Adenosine Diphosphate 119-122 purinergic receptor P2X 1 Homo sapiens 23-28 24508339-3 2014 Using X-ray crystallography, we demonstrate that MiD51 contains a nucleotidyl transferase domain that binds ADP with high affinity. Adenosine Diphosphate 108-111 mitochondrial elongation factor 1 Homo sapiens 49-54 10970768-3 2000 After elevating cAMP or cGMP levels using prostaglandin E(1)or sodium nitroprusside, prior P(2X1)desensitization reduced the integral of the ADP-evoked response to about 70% of control. Adenosine Diphosphate 141-144 purinergic receptor P2X 1 Homo sapiens 91-96 24508339-8 2014 Our results reveal ADP as an essential cofactor for MiD51 during mitochondrial fission. Adenosine Diphosphate 19-22 mitochondrial elongation factor 1 Homo sapiens 52-57 10970768-7 2000 These results indicate that both the P(2X1)and P(2T AC)receptors play a significant role in ADP-evoked Ca(2+)signalling in human platelets. Adenosine Diphosphate 92-95 purinergic receptor P2X 1 Homo sapiens 37-42 10816552-6 2000 Furthermore, when co-expressed with the wild type receptor in Xenopus oocytes, the mutated protein exhibited a dose-dependent dominant negative effect on the normal ATP or ADP-induced P2X1 channel activity. Adenosine Diphosphate 172-175 purinergic receptor P2X, ligand gated ion channel, 1 L homeolog Xenopus laevis 184-188 24299989-5 2014 Via coupled enzyme reactions involving ADP-hexokinase, glucose-6-phosphate dehydrogenase, and diaphorase, the ADP is utilized for conversion of resazurin to resorufin, which is determined by fluorescence measurement. Adenosine Diphosphate 39-42 glucose-6-phosphate dehydrogenase Homo sapiens 55-88 24515348-6 2014 Although MiD51 lacks catalytic residues for transferase activity, it specifically binds guanosine diphosphate and adenosine diphosphate. Adenosine Diphosphate 114-135 mitochondrial elongation factor 1 Homo sapiens 9-14 10748060-4 2000 In the presence of ADP, the effect of head phosphorylation was even more dramatic, in that at all levels of myosin head/actin, phosphorylation was necessary to affect energy transfer. Adenosine Diphosphate 19-22 myosin heavy chain 14 Homo sapiens 108-114 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 heat shock protein family A (Hsp70) member 4 Homo sapiens 177-182 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 heat shock protein family A (Hsp70) member 4 Homo sapiens 177-182 25210228-8 2014 Redistribution of NTPDase2, but not of NTPDase3, from ganglion cell bodies to myenteric nerve terminals leads to preferential ADP accumulation from released ATP, thus contributing to the prolonged inhibition of muscle-bound ecto-5"-nucleotidase/CD73 and to the delay of adenosine formation at the inflamed neuromuscular synapse. Adenosine Diphosphate 126-129 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 18-26 10825448-8 2000 Therefore, this enzyme was exposed to DEPC, and since hydrolysis of ATP and ADP by potato apyrase was insensitive to modification with DEPC, it was concluded that His-59 is the essential residue in CD39 that is affected by DEPC modification in a way that causes inactivation of the enzyme. Adenosine Diphosphate 76-79 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 198-202 25242873-6 2014 In response to poly (I:C), with or without ATP and/or ADP, HT-29 cells released IL-8 and this secretion was modulated by the presence of NTPDase2 and adenylate kinase. Adenosine Diphosphate 54-57 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 137-145 10904836-1 2000 The adenine nucleotide translocator (ANT), the only mitochondrial carrier for ADP and ATP, combines mitochondrial energy-producing and cytosolic energy-consuming processes. Adenosine Diphosphate 78-81 solute carrier family 25 member 6 Homo sapiens 37-40 24515454-8 2014 According to these studies, in contrast to hGDH1 that maintains basal activity at 35-40 % of its maximal, hGDH2 displays low basal activity that is highly responsive to activation by rising levels of ADP and/or L-leucine which can also act synergistically. Adenosine Diphosphate 200-203 glutamate dehydrogenase 2 Homo sapiens 106-111 24078249-0 2014 Enhancement of ADP release from the RAD51 presynaptic filament by the SWI5-SFR1 complex. Adenosine Diphosphate 15-18 RAD51 recombinase Homo sapiens 36-41 24386454-8 2013 Results showed that pretreatment of human platelets with lower concentrations of GLA (0.01 mug/ml, 0.1 mug/ml) significantly inhibited platelet aggregation induced by collagen (P<0.001) and CRP (P<0.01), a synthetic GPVI ligand, but not by ADP and U46619. Adenosine Diphosphate 246-249 galactosidase alpha Homo sapiens 81-84 24244016-7 2013 LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 receptors. Adenosine Diphosphate 45-48 cysteinyl leukotriene receptor 2 Mus musculus 5-12 23806663-9 2013 Because these complex lipids activate the small GTPase Rac1, we explored the role of PTEN in ADP-modulated Rac1 activation. Adenosine Diphosphate 93-96 Rac family small GTPase 1 Homo sapiens 107-111 23806663-10 2013 We used a FRET biosensor for Rac1 to show that ADP-dependent Rac1 activation is blocked by siRNA-mediated PTEN knockdown. Adenosine Diphosphate 47-50 Rac family small GTPase 1 Homo sapiens 29-33 23806663-10 2013 We used a FRET biosensor for Rac1 to show that ADP-dependent Rac1 activation is blocked by siRNA-mediated PTEN knockdown. Adenosine Diphosphate 47-50 Rac family small GTPase 1 Homo sapiens 61-65 23629754-5 2013 Our study demonstrated that ADP stimulation of P2Y13 R(+/+) (but not P2Y13 R(-/-) ) adherent bone marrow stromal cells (BMSCs) increased significantly the formation of alkaline phosphatase-colony-forming units (CFU-ALP) as well as the expression of osteoblastic markers (osterix, alkaline phosphatase, and collagen I) involved in the maturation of preosteoblasts into osteoblasts. Adenosine Diphosphate 28-31 Sp7 transcription factor 7 Mus musculus 271-278 10836495-5 2000 However, kinetics shows that the binding of myosin to actin is a two-step process which affects both ATP and ADP affinity and vice versa. Adenosine Diphosphate 109-112 myosin heavy chain 14 Homo sapiens 44-50 24167257-1 2013 The complex kinetics of Pi and ADP release by the chaperonin GroEL/GroES is influenced by the presence of unfolded substrate protein (SP). Adenosine Diphosphate 31-34 heat shock protein family D (Hsp60) member 1 Homo sapiens 61-66 24167257-4 2013 The rate-determining step of the asymmetric cycle is the release of ADP from the trans ring of the GroEL-GroES1 "bullet" complex that is, consequently, the predominant species. Adenosine Diphosphate 68-71 heat shock protein family D (Hsp60) member 1 Homo sapiens 99-104 24167257-9 2013 Now ADP release precedes the release of Pi, and the rate-determining step of the symmetric cycle becomes the hydrolysis of ATP by the symmetric GroEL-GroES2 football complex that is, consequently, the predominant species. Adenosine Diphosphate 4-7 heat shock protein family D (Hsp60) member 1 Homo sapiens 144-149 10836495-8 2000 Indeed, cryoelectron microscopy has revealed other angles of the lever arm induced by ADP binding to a smooth muscle actin-myosin complex. Adenosine Diphosphate 86-89 myosin heavy chain 14 Homo sapiens 123-129 10836506-5 2000 (i) A modest motion of the lever arm on ADP release can serve to regulate the fraction of myosin bound to the thin filament, in order to recruit more heads at higher loads. Adenosine Diphosphate 40-43 myosin heavy chain 14 Homo sapiens 90-96 10744353-10 2000 Sometimes the mechanical event is delayed after the ADP is released from myosin. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 73-79 23990462-9 2013 CHIP binding to Hsc70 binding was also stimulated by the presence of an Hsc70 client with a preference for the ADP-bound state. Adenosine Diphosphate 111-114 heat shock protein family A (Hsp70) member 8 Homo sapiens 16-21 23990462-9 2013 CHIP binding to Hsc70 binding was also stimulated by the presence of an Hsc70 client with a preference for the ADP-bound state. Adenosine Diphosphate 111-114 heat shock protein family A (Hsp70) member 8 Homo sapiens 72-77 10851782-0 2000 Physiological and pathological significance of the CD38-cyclic ADP-ribose signaling system. Adenosine Diphosphate 63-66 CD38 molecule Homo sapiens 51-55 23625657-2 2013 Redistribution of hPuf-A from the nucleolus to the nucleoplasm upon genotoxic stress modulates the poly(ADP-ribosyl)ation activity of PARP-1. Adenosine Diphosphate 104-107 pumilio RNA binding family member 3 Homo sapiens 18-24 23897816-6 2013 Here we show using isothermal titration calorimetry that mammalian GMF has very low affinity for ATP-bound Arp2/3 complex but binds ADP-bound Arp2/3 complex with 0.7 muM affinity. Adenosine Diphosphate 132-135 glia maturation factor beta Homo sapiens 67-70 23575529-3 2013 Here, we show that in the presence of extracellular NAD(+) , ART2.2 caused ADP-ribosylation of CD8-beta on murine CD8(+) T cells in vitro and in vivo. Adenosine Diphosphate 75-78 CD8 antigen, beta chain 1 Mus musculus 95-103 11096182-7 2000 Soluble recombinant CD39, an ecto-ADPase, protects against stroke in animal models by metabolizing released ADP/ATP to antiplatelet derivatives. Adenosine Diphosphate 34-37 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 20-24 22884258-5 2013 The agonists EC(50) calculated in hirudin blood were 2.70 muM ADP, 0.85 mug/ml collagen, 0.03 mM arachidonic acid and 165.7 muM Par-4 agonist in the Wistar rat, and 0.95 muM ADP and 0.23 mug/ml collagen in the Beagle dog. Adenosine Diphosphate 174-177 pro-apoptotic WT1 regulator Rattus norvegicus 128-133 10570140-7 1999 The net result is a myosin unlike any previously characterized, in that ADP release is the rate-limiting step for the actin-activated ATPase cycle. Adenosine Diphosphate 72-75 myosin heavy chain 14 Homo sapiens 20-26 23549485-14 2013 CYP2C19*2 allele carriers had a higher platelet reactivity after clopidogrel loading measured by adenosine diphosphate-induced aggregation in LTA (P=0.008) and vasodilator-stimulated phosphoprotein phosphorylation (P=0.035); however, there was no difference in the inflammatory markers. Adenosine Diphosphate 97-118 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 23703906-4 2013 In addition, loss of Miner1 caused a depletion of ER Ca(2+) stores, a dramatic increase in mitochondrial Ca(2+) load, increased reactive oxygen and nitrogen species, an increase in the GSSG/GSH and NAD(+)/NADH ratios, and an increase in the ADP/ATP ratio consistent with enhanced ATP utilization. Adenosine Diphosphate 241-244 CDGSH iron sulfur domain 2 Mus musculus 21-27 23420347-4 2013 Here we obtained hGDH1 and hGDH2 in recombinant form and studied their Km for ammonia in the presence of 1.0 mM ADP. Adenosine Diphosphate 112-115 glutamate dehydrogenase 2 Homo sapiens 27-32 23420347-6 2013 Moreover, lowering the ADP concentration to 0.1 mM not only increased the K0.5 [NH4 (+)] of hGDH2, but also introduced a positive cooperative binding phenomenon in this isoenzyme. Adenosine Diphosphate 23-26 glutamate dehydrogenase 2 Homo sapiens 92-97 23640828-6 2013 RESULTS: The difference before and after clopidogrel treatment on adenosine diphosphate-induced platelet aggregation was significantly smaller in patients carrying 1 or 2 CYP2C19 loss-of-function alleles (*2, *3) compared with patients carrying none. Adenosine Diphosphate 66-87 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 171-178 23485713-0 2013 On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells. Adenosine Diphosphate 67-70 MIR7-3 host gene Homo sapiens 108-113 23676293-5 2013 R-138727 and the GPIIb-IIIa antagonists had additive inhibitory effects on collagen-stimulated platelet aggregation and on the collagen plus ADP-stimulated level of activated platelet surface GPIIb-IIIa. Adenosine Diphosphate 141-144 integrin subunit alpha 2b Homo sapiens 17-22 23676293-5 2013 R-138727 and the GPIIb-IIIa antagonists had additive inhibitory effects on collagen-stimulated platelet aggregation and on the collagen plus ADP-stimulated level of activated platelet surface GPIIb-IIIa. Adenosine Diphosphate 141-144 integrin subunit alpha 2b Homo sapiens 192-197 23680151-0 2013 Function of BRCA1 in the DNA damage response is mediated by ADP-ribosylation. Adenosine Diphosphate 60-63 BRCA1 DNA repair associated Homo sapiens 12-17 23600369-1 2013 CD39 (NTPDase1), a critical immune and vascular ecto-nucleotidase, hydrolyses pro-inflammatory and pro-thrombotic nucleotides (adenosine-5"-triphosphate (ATP) and adenosine diphosphate) to adenosine. Adenosine Diphosphate 163-184 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 23600369-1 2013 CD39 (NTPDase1), a critical immune and vascular ecto-nucleotidase, hydrolyses pro-inflammatory and pro-thrombotic nucleotides (adenosine-5"-triphosphate (ATP) and adenosine diphosphate) to adenosine. Adenosine Diphosphate 163-184 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 6-14 23340049-6 2013 Obesity was independently associated with higher residual platelet reactivity by the VASP assay and MEA ADP, and with platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP (all P <= 0.04). Adenosine Diphosphate 201-204 integrin subunit alpha 2b Homo sapiens 175-180 23622245-6 2013 TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. Adenosine Diphosphate 14-17 proteasome inhibitor subunit 1 Homo sapiens 34-38 23622245-6 2013 TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. Adenosine Diphosphate 14-17 proteasome inhibitor subunit 1 Homo sapiens 135-139 23305784-6 2013 Vanadate-induced ADP trapping of MDR3 NBDs in the chimera protein was stimulated by verapamil as was MDR1 NBDs. Adenosine Diphosphate 17-20 ATP binding cassette subfamily B member 4 Homo sapiens 33-37 23313842-5 2013 CONCLUSIONS: This is the first application of semi-empirical MO calculations to the macromolecular complex of the native bullet-shaped chaperonin (GroEL-GroES-ADP homolog) from T. thermophilus. Adenosine Diphosphate 159-162 chaperonin GroES Escherichia coli 153-158 22212466-10 2013 Compared to UFH treatment, the adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP)-induced thrombospondin expression post-PCI was reduced when bivalirudin was administrated during intervention. Adenosine Diphosphate 31-52 TRAP Homo sapiens 63-99 22212466-10 2013 Compared to UFH treatment, the adenosine diphosphate (ADP) and thrombin receptor-activating peptide (TRAP)-induced thrombospondin expression post-PCI was reduced when bivalirudin was administrated during intervention. Adenosine Diphosphate 31-52 TRAP Homo sapiens 101-105 23506884-5 2013 The objective of this review is to summarize the current knowledge of the involvement of the ADP/ATP carrier, encoded by the SLC25A4, SLC25A5, SLC25A6 and SLC25A31 genes, in human diseases and of the efforts made at designing different model systems to study this carrier and the associated pathologies through biochemical, genetic, and structural approaches. Adenosine Diphosphate 93-96 solute carrier family 25 member 5 Homo sapiens 134-141 23490430-10 2013 Citalopram concentration-dependently inhibited the phosphorylation of Akt, GSK3beta, p38 MAPK and Syk induced by ADP, but showed no effect on the decrease of cAMP and VASP phosphorylation. Adenosine Diphosphate 113-116 spleen associated tyrosine kinase Homo sapiens 98-101 23453806-6 2013 The glucose influx through GLUT1 restores ATP-to-ADP ratios in the short run and ultimately induces TXNIP protein production to suppress glucose uptake once energy homeostasis is reestablished. Adenosine Diphosphate 49-52 solute carrier family 2 member 1 Homo sapiens 27-32 23329646-6 2013 Omega-3 PUFA also reduced P-selectin expression (40.5% +- 2.9% vs. 34.4% +- 2.4%, p = 0.049) on platelets and platelet-monocyte aggregates (38.5% +- 2.6% vs. 31.4% +- 2.5%, p = 0.022) after activation with ADP 0.5 microM. Adenosine Diphosphate 206-209 pumilio RNA binding family member 3 Homo sapiens 8-12 23289424-0 2013 Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4. Adenosine Diphosphate 66-69 H1.4 linker histone, cluster member Homo sapiens 86-98 24348227-4 2013 Unbiased MD simulations were performed for Hsp70-DnaK chaperone in nucleotide-free, ADP-bound and ATP-bound states. Adenosine Diphosphate 84-87 heat shock protein family A (Hsp70) member 4 Homo sapiens 43-48 23536768-8 2013 Using intracellular calcium as a reporter, we found that although NTPDase2 hydrolyzed ATP and generated sustainable ADP levels, only ATP contributed to increased intracellular calcium via P2Y2 receptor activation. Adenosine Diphosphate 116-119 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 66-74 23118415-3 2012 Here we report the crystal structure of the kinase domain of Clostridium thermocellum Pnkp bound to ATP Mg2+ (substrate complex) and ADP Mg2+ (product complex). Adenosine Diphosphate 133-136 polynucleotide kinase 3'-phosphatase Homo sapiens 86-90 10555558-7 1999 Luminal addition of P2Y1 [ADP, 2-methylthio-ATP (2MeSATP)] and P2Y6 (UDP) receptor agonists had no effect on ion transport. Adenosine Diphosphate 26-29 purinergic receptor P2Y1 Homo sapiens 20-24 23007400-8 2012 We also found that the addition of ATP and ADP promote oligomerization of IPLA-1, which probably underlies the stimulatory effect of nucleotides on its activity. Adenosine Diphosphate 43-46 Intracellular phospholipase A1 Caenorhabditis elegans 74-80 22996695-8 2012 Likewise, we found that ADP stimulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its effects were substantially blunted in P2ry12-/- OCs. Adenosine Diphosphate 24-27 integrin beta 3 Mus musculus 74-88 22996695-8 2012 Likewise, we found that ADP stimulation induced RAP1 activation in WT and integrin beta3 gene knockout (Itgb3-/-) OCs, but its effects were substantially blunted in P2ry12-/- OCs. Adenosine Diphosphate 24-27 integrin beta 3 Mus musculus 104-109 22658952-7 2012 Results showed that, in contrast to hGDH1 that maintains substantial basal activity (35-40% of its maximal capacity), hGDH2 displays low basal activity (3-8% of maximal) that is remarkably responsive to activation by rising levels of ADP and/or l-leucine. Adenosine Diphosphate 234-237 glutamate dehydrogenase 2 Homo sapiens 118-123 22745129-13 2012 The greater effect of ADP accelerating the disappearance of EP suggests that GFP-Spf1 accumulated the E1~P phosphoenzyme. Adenosine Diphosphate 22-25 ion-transporting P-type ATPase SPF1 Saccharomyces cerevisiae S288C 81-85 22947934-4 2012 Here we attempt to define the biochemical pathways populated by myosin Va by examining the velocity, processive run-length, and individual steps of a Qdot-labeled myosin Va in various substrate conditions (i.e., changes in ATP, ADP, and P(i)) under zero load in the single-molecule total internal reflection fluorescence microscopy assay. Adenosine Diphosphate 228-231 myosin VA Homo sapiens 64-73 22473005-7 2012 Insulin treatment suppresses the ADP-ribosylase activity of TNKS, leading to a reduction in ADP ribosylation and ubiquitination of both Axin and TNKS, and a concurrent stabilization of the complex. Adenosine Diphosphate 33-36 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Mus musculus 60-64 22473005-7 2012 Insulin treatment suppresses the ADP-ribosylase activity of TNKS, leading to a reduction in ADP ribosylation and ubiquitination of both Axin and TNKS, and a concurrent stabilization of the complex. Adenosine Diphosphate 33-36 axin 1 Mus musculus 136-140 22473005-7 2012 Insulin treatment suppresses the ADP-ribosylase activity of TNKS, leading to a reduction in ADP ribosylation and ubiquitination of both Axin and TNKS, and a concurrent stabilization of the complex. Adenosine Diphosphate 33-36 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Mus musculus 145-149 22613024-1 2012 Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AMP, which then is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine. Adenosine Diphosphate 173-176 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 180-228 22613024-1 2012 Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AMP, which then is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine. Adenosine Diphosphate 173-176 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 230-237 22613024-1 2012 Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AMP, which then is hydrolyzed by ecto-5"-nucleotidase (CD73) to adenosine. Adenosine Diphosphate 173-176 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 239-243 22613024-4 2012 ENTPD-1 expression decreased whole-blood aggregation after stimulation by ADP, an effect negated by adenosine-5"-0-(2-thiodiphosphate) trilithium salt, Ado-5"-PP[S] stimulation, and limited the ability to maintain the platelet fibrinogen receptor, glycoprotein alpha(IIb)/beta(3), in a fully activated state, which is critical for thrombus formation. Adenosine Diphosphate 74-77 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-7 22773752-5 2012 BEX5/RabA1b localizes to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking processes like those regulated by GTP exchange factors on ADP-ribosylation factors GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1, which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. Adenosine Diphosphate 161-164 RAB GTPase homolog A1B Arabidopsis thaliana 0-4 22773752-5 2012 BEX5/RabA1b localizes to trans-Golgi network/early endosomes (TGN/EE) and acts on distinct trafficking processes like those regulated by GTP exchange factors on ADP-ribosylation factors GNOM-LIKE1 and HOPM INTERACTOR7/BFA-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1, which regulate trafficking at the Golgi apparatus and TGN/EE, respectively. Adenosine Diphosphate 161-164 RAB GTPase homolog A1B Arabidopsis thaliana 5-11 22362735-4 2012 In the HsRad51/single-stranded DNA filament, the primary intermediate of the strand exchange reaction, ATP/Ca(2+) induces an ordered conformation of DNA, with preferentially perpendicular orientation of nucleobases relative to the filament axis, while the presence of ATP/Mg(2+), ADP/Mg(2+) or ADP/Ca(2+) does not. Adenosine Diphosphate 280-283 RAD51 recombinase Homo sapiens 7-14 22362735-4 2012 In the HsRad51/single-stranded DNA filament, the primary intermediate of the strand exchange reaction, ATP/Ca(2+) induces an ordered conformation of DNA, with preferentially perpendicular orientation of nucleobases relative to the filament axis, while the presence of ATP/Mg(2+), ADP/Mg(2+) or ADP/Ca(2+) does not. Adenosine Diphosphate 294-297 RAD51 recombinase Homo sapiens 7-14 22547793-5 2012 Results agree well with experiments on the nucleotide bias of Get3 open and closed structures in the crystallographically observed no-nucleotide, two ATP, and two ADP states, and also reveal their populations in the asymmetric one ATP and one ADP cases. Adenosine Diphosphate 163-166 guanine nucleotide exchange factor GET3 Saccharomyces cerevisiae S288C 62-66 22547793-5 2012 Results agree well with experiments on the nucleotide bias of Get3 open and closed structures in the crystallographically observed no-nucleotide, two ATP, and two ADP states, and also reveal their populations in the asymmetric one ATP and one ADP cases. Adenosine Diphosphate 243-246 guanine nucleotide exchange factor GET3 Saccharomyces cerevisiae S288C 62-66 22207763-0 2012 Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C. The activity of ATP-sensitive potassium (K(ATP)) channels is governed by the concentration of intracellular ATP and ADP and is thus responsive to the metabolic status of the cell. Adenosine Diphosphate 221-224 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 59-65 22075250-8 2012 Whereas Rap1 signaling directly controls sustained Rac1 activation, Rac1 affects CalDAG-GEFI- and P2Y12-dependent Rap1 activation via its role in calcium mobilization and granule/ADP release, respectively. Adenosine Diphosphate 179-182 Rac family small GTPase 1 Homo sapiens 68-72 22878205-1 2012 The catalytic domain of rice (Oryza sativa japonica) granule bound starch synthase I (OsGBSSI-CD) was overexpressed and the three-dimensional structures of the ligand-free and ADP-bound forms were determined. Adenosine Diphosphate 176-179 soluble starch synthase 1, chloroplastic/amyloplastic Oryza sativa Japonica Group 67-84 21642242-10 2011 While no differences in the increase in MPA and CD41 expression were observed after EST-1 and EST-2, ADP stimulation after EST-2 induced a lower increase in MPA (+18.3+-8.1% vs +27.9+-9.7%, p<0.001) and CD41 (+18.3+-9.2% vs +27.2+-12.4%, p<0.001) than after EST-1. Adenosine Diphosphate 101-104 integrin subunit alpha 2b Homo sapiens 206-210 21608060-10 2011 Therefore, the Mg(2+) ion-mediated network, including the P(i) and water molecules, increases the affinity of Hsp70 for ADP, and thus the dissociation of ADP is slow. Adenosine Diphosphate 122-125 heat shock protein family A (Hsp70) member 4 Homo sapiens 112-117 21608060-10 2011 Therefore, the Mg(2+) ion-mediated network, including the P(i) and water molecules, increases the affinity of Hsp70 for ADP, and thus the dissociation of ADP is slow. Adenosine Diphosphate 156-159 heat shock protein family A (Hsp70) member 4 Homo sapiens 112-117 21470666-11 2011 ADP induced a higher increase in CD41 platelet expression in STEMI patients compared to controls both at 1 and 6 months (P < 0.001). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 33-37 21527445-5 2011 METHODS AND RESULTS: In 1524 patients undergoing percutaneous coronary intervention, ADP-induced platelet aggregation was assessed in relation to PON1 Q192R and CYP2C19*2 genotypes. Adenosine Diphosphate 85-88 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 161-168 21590746-2 2011 We have built structural models for a myosin V monomer complexed with filamentous actin at four biochemical states [adenosine diphosphate (ATP)-, adenosine diphosphate (ADP)-phosphate-, ADP-bound or nucleotide-free]. Adenosine Diphosphate 116-137 myosin VA Homo sapiens 38-46 21590746-2 2011 We have built structural models for a myosin V monomer complexed with filamentous actin at four biochemical states [adenosine diphosphate (ATP)-, adenosine diphosphate (ADP)-phosphate-, ADP-bound or nucleotide-free]. Adenosine Diphosphate 146-167 myosin VA Homo sapiens 38-46 21590746-2 2011 We have built structural models for a myosin V monomer complexed with filamentous actin at four biochemical states [adenosine diphosphate (ATP)-, adenosine diphosphate (ADP)-phosphate-, ADP-bound or nucleotide-free]. Adenosine Diphosphate 169-172 myosin VA Homo sapiens 38-46 21590746-2 2011 We have built structural models for a myosin V monomer complexed with filamentous actin at four biochemical states [adenosine diphosphate (ATP)-, adenosine diphosphate (ADP)-phosphate-, ADP-bound or nucleotide-free]. Adenosine Diphosphate 186-189 myosin VA Homo sapiens 38-46 21391917-6 2011 Finally, we found that the re-sensitization of PAR1 signalling-induced aggregation via PAR4 relied on PKC-mediated release of both ADP from dense granules and fibrinogen from alpha-granules. Adenosine Diphosphate 131-134 F2R like thrombin or trypsin receptor 3 Homo sapiens 87-91 10544922-7 1999 Adenosine-5"-phosphate-3"-phosphosulfate, a P2Y1 receptor antagonist, completely blocked ADP-induced inositol 1,4,5-trisphosphate and inositol 1,3.4-trisphosphate formation suggesting that P2TAC-mediated activation of Gi (or other G proteins) does not activate phospholipase C. These results suggest that a signaling event downstream from Gi, independent of the inhibition of platelet adenylyl cyclase, contributes to alphaIIb beta3 activation. Adenosine Diphosphate 89-92 purinergic receptor P2Y1 Homo sapiens 44-57 21169403-2 2011 We measured the in vivo diameter of pial arterioles in sedentary and exercised nondiabetic and diabetic rats in response to an endothelial NOS (eNOS)-dependent (ADP), an neuronal NOS (nNOS)-dependent [N-methyl-D-aspartate (NMDA)], and a NOS-independent (nitroglycerin) agonist. Adenosine Diphosphate 161-164 nitric oxide synthase 3 Rattus norvegicus 127-142 21169403-2 2011 We measured the in vivo diameter of pial arterioles in sedentary and exercised nondiabetic and diabetic rats in response to an endothelial NOS (eNOS)-dependent (ADP), an neuronal NOS (nNOS)-dependent [N-methyl-D-aspartate (NMDA)], and a NOS-independent (nitroglycerin) agonist. Adenosine Diphosphate 161-164 nitric oxide synthase 3 Rattus norvegicus 144-148 10508401-7 1999 The results indicate that myosin with and without ADP, intermediates in the myosin ATPase hydrolytic pathway, are effective regulators of tropomyosin position, which might play a role in the regulation of smooth muscle contraction. Adenosine Diphosphate 50-53 myosin heavy chain 14 Homo sapiens 26-32 21269340-11 2011 Unlike other manipulations that generate persistent depression of the ADP in CA3-PCs, DHPG-mediated ADP depression was insensitive to the Kv7 channel inhibitor 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride (XE991) and strong intracellular Ca(2+) buffering by 1,2-Bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid (BAPTA). Adenosine Diphosphate 70-73 carbonic anhydrase 3 Rattus norvegicus 77-80 21269340-12 2011 Synaptic activation of mGluRs in the associational-commissural pathway also resulted in persistent depression of the ADP in postsynaptic CA3-PCs, which was blocked by LY367385. Adenosine Diphosphate 117-120 carbonic anhydrase 3 Rattus norvegicus 137-140 10508401-7 1999 The results indicate that myosin with and without ADP, intermediates in the myosin ATPase hydrolytic pathway, are effective regulators of tropomyosin position, which might play a role in the regulation of smooth muscle contraction. Adenosine Diphosphate 50-53 myosin heavy chain 14 Homo sapiens 76-82 21135101-5 2011 One in vitro generated LT mutant (LTK4R), in which the lysine at position 4 of the A subunit was replaced by arginine, showed most of the LT4 features with an ~10-fold reduction of the cytotonic effects, ADP-ribosylation activity, and accumulation of intracellular cAMP in Y1 cells. Adenosine Diphosphate 204-207 Leucine transport, high Homo sapiens 23-25 10471369-1 1999 CD39 is a human lymphoid cell activation antigen, (also referred to E-ATPDase or apyrase) that hydrolyzes extracellular ATP and ADP. Adenosine Diphosphate 128-131 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 21081493-7 2011 Moreover, HDAC 2 and 3 are released from the promoter with an IL-4 signal, this is aided by the ADP-ribosylation of the HDACs by PARP-14. Adenosine Diphosphate 96-99 poly(ADP-ribose) polymerase family member 14 Homo sapiens 129-136 10471369-1 1999 CD39 is a human lymphoid cell activation antigen, (also referred to E-ATPDase or apyrase) that hydrolyzes extracellular ATP and ADP. Adenosine Diphosphate 128-131 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 16-48 20888882-8 2011 The differentiated ADP induced by retinoic acid was characterized by immunostaining with anti-GFAP or anti-Tuj1 antibody. Adenosine Diphosphate 19-22 glial fibrillary acidic protein Rattus norvegicus 94-98 10433719-0 1999 Phosphorylation regulates the ADP-induced rotation of the light chain domain of smooth muscle myosin. Adenosine Diphosphate 30-33 myosin heavy chain 14 Homo sapiens 94-100 21329420-5 2011 In healthy volunteers positive associations were observed between GP IIb-IIIa number and the level of ADP-induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of aspirin or non-saturating concentrations of GP IIb-IIIa blockers. Adenosine Diphosphate 102-105 integrin subunit alpha 2b Homo sapiens 66-72 21329420-5 2011 In healthy volunteers positive associations were observed between GP IIb-IIIa number and the level of ADP-induced aggregation when this relationship was analysed in untreated platelet-rich plasma (PRP) as well as upon in vitro addition of aspirin or non-saturating concentrations of GP IIb-IIIa blockers. Adenosine Diphosphate 102-105 integrin subunit alpha 2b Homo sapiens 283-289 10433719-1 1999 We have observed the effects of MgADP and thiophosphorylation on the conformational state of the light chain domain of myosin in skinned smooth muscle. Adenosine Diphosphate 32-37 myosin heavy chain 14 Homo sapiens 119-125 10433719-4 1999 The two observed conformations are similar to those found previously for smooth muscle myosin S1; the final state corresponds to the major conformation of S1 in the absence of ADP, while the intermediate state corresponds to the conformation of S1 with ADP bound. Adenosine Diphosphate 176-179 myosin heavy chain 14 Homo sapiens 87-93 10433719-4 1999 The two observed conformations are similar to those found previously for smooth muscle myosin S1; the final state corresponds to the major conformation of S1 in the absence of ADP, while the intermediate state corresponds to the conformation of S1 with ADP bound. Adenosine Diphosphate 253-256 myosin heavy chain 14 Homo sapiens 87-93 10418796-6 1999 Alpha-granule degranulation was a higher threshold event (33% of platelets expressed P-selectin in response to 1.0 microM ADP). Adenosine Diphosphate 122-125 selectin P Homo sapiens 85-95 21853082-3 2011 In this assay, CD39L2, a nucleotidase, is added into a kinase reaction to hydrolyze ADP to AMP and phosphate. Adenosine Diphosphate 84-87 ectonucleoside triphosphate diphosphohydrolase 6 Homo sapiens 15-21 10418796-8 1999 Patients with acute coronary syndromes (on aspirin) had significantly increased P-selectin expression in response to ADP compared with healthy subjects (on aspirin), but no difference in ADP-induced fibrinogen binding was observed. Adenosine Diphosphate 117-120 selectin P Homo sapiens 80-90 21853082-5 2011 As ADP hydrolysis by CD39L2 displays a first-order rate constant, relatively simple equations are derived to calculate the coupling rate and the lagging time of the coupling reaction, allowing one to obtain kinase kinetic parameters without the completion of the coupling reaction. Adenosine Diphosphate 3-6 ectonucleoside triphosphate diphosphohydrolase 6 Homo sapiens 21-27 10393252-0 1999 One of the non-exchangeable nucleotides of the mitochondrial F1-ATPase is bound at a beta-subunit: evidence for a non-rotatory two-site catalytic mechanism In active MF1, one of the two non-exchangeable tightly bound adenine nucleotides is an ATP, while the other is an ADP. The respective sites are called the T-site and the D-site. Adenosine Diphosphate 271-274 flap structure-specific endonuclease 1 Homo sapiens 167-170 20728084-8 2010 Levels of IL-6, RANTES, and CRP correlated well with ADP and arachidonic acid (AA)-induced MEA. Adenosine Diphosphate 53-56 C-C motif chemokine ligand 5 Homo sapiens 16-22 20816663-5 2010 These results are attributable to the delay in the attachment of the motor"s leading head (ADP P(i) state) to actin, induced by the competitive binding of drebrin-E to actin, whereas the rate of ADP release from the trailing head (the rate-limiting step in the ATPase cycle of myosin V) is unaffected. Adenosine Diphosphate 91-94 myosin VA Homo sapiens 277-285 20816663-5 2010 These results are attributable to the delay in the attachment of the motor"s leading head (ADP P(i) state) to actin, induced by the competitive binding of drebrin-E to actin, whereas the rate of ADP release from the trailing head (the rate-limiting step in the ATPase cycle of myosin V) is unaffected. Adenosine Diphosphate 195-198 myosin VA Homo sapiens 277-285 10393252-2 1999 When MF1 is stored at room temperature in 50% glycerol and 100 mM Tris-HCl (pH 7.3) after slow passage through a Sephadex column, the tightly bound ATP is slowly dephosphorylated to ADP which is subsequently released, without effect on activity. Adenosine Diphosphate 183-186 flap structure-specific endonuclease 1 Homo sapiens 6-9 10395026-2 1999 In human platelets, the P2X1 receptor mediates a rapid increase in intracellular Ca2+ concentration ([Ca2+]i) upon stimulation with ADP. Adenosine Diphosphate 132-135 purinergic receptor P2X 1 Homo sapiens 24-37 21122278-1 2010 The mitochondrial UCP2 mediates glucose-stimulated insulin secretion by decreasing intracellular ATP/ADP ratio. Adenosine Diphosphate 101-104 uncoupling protein 2 Rattus norvegicus 18-22 20876358-2 2010 K(ATP) channels carrying this mutation (Kir6.2-G334D/SUR1 channels) were activated by MgATP and MgADP with an EC(50) of 112 and 8 microM, respectively. Adenosine Diphosphate 96-101 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 40-46 20876358-4 2010 The EC(50) for activation of Kir6.2-G334D/SUR1 currents by MgADP was lower than that for MgATP, and the time course of activation was faster. Adenosine Diphosphate 59-64 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 29-35 20876358-8 2010 By comparing our results with those obtained for wild-type K(ATP) channels, we conclude that the MgADP sensitivity of the wild-type K(ATP) channel can be described quantitatively by a combination of inhibition at Kir6.2 (measured for wild-type channels in the absence of Mg(2+)) and activation via SUR1 (determined for Kir6.2-G334D/SUR1 channels). Adenosine Diphosphate 97-102 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 213-219 20876358-8 2010 By comparing our results with those obtained for wild-type K(ATP) channels, we conclude that the MgADP sensitivity of the wild-type K(ATP) channel can be described quantitatively by a combination of inhibition at Kir6.2 (measured for wild-type channels in the absence of Mg(2+)) and activation via SUR1 (determined for Kir6.2-G334D/SUR1 channels). Adenosine Diphosphate 97-102 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 319-325 20657015-10 2010 RIMKLA was shown to produce stoichiometric amounts of NAAG and ADP, in agreement with its belonging to the ATP-grasp family of ligases. Adenosine Diphosphate 63-66 ribosomal modification protein rimK like family member A Homo sapiens 0-6 10318853-4 1999 Their activation by nucleotide agonists (ADP and ATP for P2Y1; ATP and UTP for P2Y2) elevates [Ca2+]i and moderately induces expression of the c-fos proto-oncogene. Adenosine Diphosphate 41-44 purinergic receptor P2Y1 Homo sapiens 57-61 20632993-5 2010 To provide a structural framework for understanding these mutations and to guide structure-assisted drug discovery efforts, the X-ray crystal structure of the unphosphorylated ALK catalytic domain was determined in the apo, ADP- and staurosporine-bound forms. Adenosine Diphosphate 224-227 ALK receptor tyrosine kinase Homo sapiens 176-179 10365753-3 1999 We report here the characteristics of the P2Y1 receptor in a patient presenting a selective deficiency of ADP-induced aggregation. Adenosine Diphosphate 106-109 purinergic receptor P2Y1 Homo sapiens 42-55 20862304-1 2010 Catalysis of ADP-ATP exchange by nucleotide exchange factors (NEFs) is central to the activity of Hsp70 molecular chaperones. Adenosine Diphosphate 13-16 heat shock protein family A (Hsp70) member 4 Homo sapiens 98-103 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 0-21 integrin subunit alpha 2b Homo sapiens 84-89 10220377-3 1999 The absence of Ant1 blocks the exchange of ADP and ATP across the mitochondrial inner membrane, thus inhibiting OXPHOS. Adenosine Diphosphate 43-46 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 15-19 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 23-26 integrin subunit alpha 2b Homo sapiens 84-89 20823666-7 2010 Adenosine diphosphate (ADP)-induced or non-ADP-induced expression of P-selectin and GPIIb/IIIa was significantly higher in AMI, ICH or DM than that in controls (P < 0.01 for each). Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 84-89 20823666-8 2010 Either SZ-21 or aspirin can inhibit the ADP-induced expression of P-selectin and GPIIb/IIIa. Adenosine Diphosphate 40-43 integrin subunit alpha 2b Homo sapiens 81-86 20441566-9 2010 Taken together, our results demonstrate that PI3Kbeta plays an important role in ADP-induced platelet aggregation. Adenosine Diphosphate 81-84 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Homo sapiens 45-53 10051438-4 1999 In vitro kinase assays with anti-beta3 precipitates demonstrated that syk activity was enhanced in ADP-stimulated platelets. Adenosine Diphosphate 99-102 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 33-38 20441566-10 2010 Moreover, PI3Kbeta mediates ADP-induced thromboxane A2 generation by regulating ERK phosphorylation. Adenosine Diphosphate 28-31 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Homo sapiens 10-18 20512316-6 2010 Furthermore, T4 PNK inhibition by the inhibitor ADP and activation by the activator spermine are shown, demonstrating the potential for high-throughput screening for inhibitors and activators. Adenosine Diphosphate 48-51 polynucleotide kinase 3'-phosphatase Homo sapiens 16-19 10037486-6 1999 In addition, the HGPRT-deficient astroglia were shown to contain lower cellular levels of ADP, ATP, and GTP, indicating that the accelerated de novo purine synthesis does not compensate adequately for the deficiency of salvage nucleotide synthesis, and higher level of UTP, probably due to enhanced de novo synthesis of pyrimidine nucleotides. Adenosine Diphosphate 90-93 hypoxanthine guanine phosphoribosyl transferase Mus musculus 17-22 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 111-114 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 156-160 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 111-114 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 200-204 20146402-4 2010 The deduced translation product shared high identity of 66%, 70%, 69%, 74%, 75% and 52% with the mitochondrial ADP/ATP carrier of Saccharomyces cerevisiae (AAC1), S. cerevisiae (AAC2), S. cerevisiae (AAC3), Kluyveromyces lactis (KlAAC), Neurospora crassa (NcAAC) and human (ANT1), respectively, and conserved the consensus sequences of all ADP/ATP carrier proteins. Adenosine Diphosphate 340-343 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 156-160 10331632-6 1999 The inhibition of PARG was presumably due to the non-covalent interactions of these proteins with free ADP-ribose polymers. Adenosine Diphosphate 103-106 poly (ADP-ribose) glycohydrolase Rattus norvegicus 18-22 10331637-4 1999 A series of blockers of the BFA-dependent ADP-ribosylation reaction identified in our laboratory inhibited the effects of BFA on Golgi morphology and, with similar potency, the ADP-ribosylation of BARS-50 and GAPDH. Adenosine Diphosphate 42-45 C-terminal binding protein 1 Rattus norvegicus 197-204 9974422-13 1999 In in vitro studies, incubation of platelets with apoA1 Milano reduced ADP-induced platelet aggregation by about 50%, but apoA1 Milano had no direct effect on vasoreactivity. Adenosine Diphosphate 71-74 apolipoprotein A1 Rattus norvegicus 50-55 20002211-3 2010 Two moieties of HSP70 were affinity-purified from human CD4(+) T cells; an ADP preparation with HSP70-bound proteins (ADP-HSP) and an ATP control preparation. Adenosine Diphosphate 75-78 heat shock protein family A (Hsp70) member 4 Homo sapiens 16-21 19932163-4 2010 A similar pattern of ATP and ADP hydrolysis changes as well as the ATP/ADP ratio in all developmental stages indicated that NTPDase3 was acutely affected after stress. Adenosine Diphosphate 29-32 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 124-132 19932163-4 2010 A similar pattern of ATP and ADP hydrolysis changes as well as the ATP/ADP ratio in all developmental stages indicated that NTPDase3 was acutely affected after stress. Adenosine Diphosphate 71-74 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 124-132 20048161-6 2010 In contrast, ATP, ADP, AMP, PLP, p-nitrophenyl phosphate, and PP(i) were hydrolyzed by TNAP-, NPP1-, and TNAP plus NPP1-containing proteoliposomes. Adenosine Diphosphate 18-21 alkaline phosphatase, liver/bone/kidney Mus musculus 87-91 20048161-6 2010 In contrast, ATP, ADP, AMP, PLP, p-nitrophenyl phosphate, and PP(i) were hydrolyzed by TNAP-, NPP1-, and TNAP plus NPP1-containing proteoliposomes. Adenosine Diphosphate 18-21 alkaline phosphatase, liver/bone/kidney Mus musculus 105-109 20009008-2 2010 In Drosophila, sesB encodes the ubiquitous isoform of adenine nucleotide translocase (ANT, the mitochondrial inner membrane ATP/ADP exchanger); null alleles are lethal, whereas hypomorphic alleles display sensitivity to a range of stressors. Adenosine Diphosphate 128-131 stress-sensitive B Drosophila melanogaster 15-19 20009008-2 2010 In Drosophila, sesB encodes the ubiquitous isoform of adenine nucleotide translocase (ANT, the mitochondrial inner membrane ATP/ADP exchanger); null alleles are lethal, whereas hypomorphic alleles display sensitivity to a range of stressors. Adenosine Diphosphate 128-131 stress-sensitive B Drosophila melanogaster 54-84 20009008-2 2010 In Drosophila, sesB encodes the ubiquitous isoform of adenine nucleotide translocase (ANT, the mitochondrial inner membrane ATP/ADP exchanger); null alleles are lethal, whereas hypomorphic alleles display sensitivity to a range of stressors. Adenosine Diphosphate 128-131 stress-sensitive B Drosophila melanogaster 86-89 20133816-1 2010 We previously showed that the MRP4 (ABCC4) transporter is expressed in human platelet delta-granules and may be involved in ADP transport. Adenosine Diphosphate 124-127 ATP binding cassette subfamily C member 4 Homo sapiens 30-34 20133816-1 2010 We previously showed that the MRP4 (ABCC4) transporter is expressed in human platelet delta-granules and may be involved in ADP transport. Adenosine Diphosphate 124-127 ATP binding cassette subfamily C member 4 Homo sapiens 36-41 20201965-9 2010 From the MS/MS database of peptides, adenosine diphosphate (ADP)-ribosylation factor 2 (arf2) and alpha-crystallin were detected in the mesenchyme of the palatal processes. Adenosine Diphosphate 37-58 ADP-ribosylation factor 2 Mus musculus 88-92 20201965-9 2010 From the MS/MS database of peptides, adenosine diphosphate (ADP)-ribosylation factor 2 (arf2) and alpha-crystallin were detected in the mesenchyme of the palatal processes. Adenosine Diphosphate 60-63 ADP-ribosylation factor 2 Mus musculus 88-92 20107186-1 2010 Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable nonselective cation channel that is stimulated by oxidative stress and specifically activated by intracellular ADP-ribose. Adenosine Diphosphate 183-186 transient receptor potential cation channel subfamily M member 2 Homo sapiens 0-41 20107186-1 2010 Transient receptor potential melastatin 2 (TRPM2) is a Ca(2+)-permeable nonselective cation channel that is stimulated by oxidative stress and specifically activated by intracellular ADP-ribose. Adenosine Diphosphate 183-186 transient receptor potential cation channel subfamily M member 2 Homo sapiens 43-48 20130685-5 2010 Previous kinetic characterization of the ATPase domain of Escherichia coli Lon protease implicates a half-site reactivity model in which only 50% of the ATP bound to Lon are hydrolyzed to yield ADP; the remaining ATPase sites remain bound with ATP and are considered non-catalytic. Adenosine Diphosphate 194-197 putative ATP-dependent Lon protease Escherichia coli 75-78 20130685-5 2010 Previous kinetic characterization of the ATPase domain of Escherichia coli Lon protease implicates a half-site reactivity model in which only 50% of the ATP bound to Lon are hydrolyzed to yield ADP; the remaining ATPase sites remain bound with ATP and are considered non-catalytic. Adenosine Diphosphate 194-197 putative ATP-dependent Lon protease Escherichia coli 166-169 10334326-7 1999 However, after pretreatment with 100 ng/ml leptin for 5 min, 1 micromol/l ADP caused aggregation. Adenosine Diphosphate 74-77 leptin Homo sapiens 43-49 10334326-9 1999 At a concentration of 2 micromol/l, ADP induced platelet aggregation, which was markedly enhanced by 30-100 ng/ml leptin in a concentration-dependent manner. Adenosine Diphosphate 36-39 leptin Homo sapiens 114-120 10030830-5 1999 In vitro ADP stimulation of platelets taken from seven healthy volunteers produced significant increases in the mean channel fluorescence intensities (MFI) for PAC-1 (148% increase) and CD62P (43% increase) but did not increase in that for CD63. Adenosine Diphosphate 9-12 selectin P Homo sapiens 186-191 10030830-5 1999 In vitro ADP stimulation of platelets taken from seven healthy volunteers produced significant increases in the mean channel fluorescence intensities (MFI) for PAC-1 (148% increase) and CD62P (43% increase) but did not increase in that for CD63. Adenosine Diphosphate 9-12 CD63 molecule Homo sapiens 240-244 9925731-2 1999 We now show that these unrelated compounds both bind to the N-terminal ATP/ADP-binding domain of Hsp90, with radicicol displaying nanomolar affinity, and both inhibit the inherent ATPase activity of Hsp90 which is essential for its function in vivo. Adenosine Diphosphate 75-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 97-102 10078874-1 1999 5-Oxo-L-prolinase (5-OPase) catalyses the hydrolysis of 5-oxo-L-proline to glutamate with concomitant stoichiometric cleavage of ATP to ADP, a reaction which is known to be part of the gamma-glutamyl cycle-an interrelated series of reactions involved in the synthesis and metabolism of glutathione. Adenosine Diphosphate 136-139 5-oxoprolinase, ATP-hydrolysing Homo sapiens 0-17 10078874-1 1999 5-Oxo-L-prolinase (5-OPase) catalyses the hydrolysis of 5-oxo-L-proline to glutamate with concomitant stoichiometric cleavage of ATP to ADP, a reaction which is known to be part of the gamma-glutamyl cycle-an interrelated series of reactions involved in the synthesis and metabolism of glutathione. Adenosine Diphosphate 136-139 5-oxoprolinase, ATP-hydrolysing Homo sapiens 19-26 9817731-5 1998 Smooth muscle myosin has a large movement of its light chain binding domain that is coupled to ADP release. Adenosine Diphosphate 95-98 myosin heavy chain 14 Homo sapiens 14-20 9722665-0 1998 ADP/vanadate mediated photocleavage of myosin light chain kinase at the autoinhibitory region. Adenosine Diphosphate 0-3 myosin light chain kinase Homo sapiens 39-64 9722665-2 1998 When MLCK was irradiated with long-wave UV (366 nm) in the presence of ADP and Vi, kinase activity was substantially decreased, and the MLCK polypeptide of 130 kDa was cleaved into several smaller fragments with apparent molecular masses of 100, 70, 60, 32, and 28 kDa. Adenosine Diphosphate 71-74 myosin light chain kinase Homo sapiens 5-9 9722665-2 1998 When MLCK was irradiated with long-wave UV (366 nm) in the presence of ADP and Vi, kinase activity was substantially decreased, and the MLCK polypeptide of 130 kDa was cleaved into several smaller fragments with apparent molecular masses of 100, 70, 60, 32, and 28 kDa. Adenosine Diphosphate 71-74 myosin light chain kinase Homo sapiens 136-140 9698557-1 1998 The adenine nucleotide translocator (ANT) is the most abundant mitochondrial inner membrane protein which catalyses the exchange of ADP and ATP between cytosol and mitochondria. Adenosine Diphosphate 132-135 solute carrier family 25 member 6 Homo sapiens 37-40 9675167-7 1998 We suggest that in the presence of ATP kinesin"s putative microtubule binding regions L8, L12, L11, alpha4, alpha5, and alpha6 form a face complementary in shape to the microtubule surface; in the presence of ADP, the microtubule binding face adopts a more convex shape relative to the ATP-bound form, reducing kinesin"s affinity to the microtubule. Adenosine Diphosphate 209-212 ribosomal protein L12 Homo sapiens 90-93 9704012-3 1998 ATP and ADP activated EC transcribed mRNA from certain transcription factor NF-kappa B target genes and expressed E-selectin protein on cell membranes. Adenosine Diphosphate 8-11 selectin E Homo sapiens 114-124 9653141-3 1998 In this study, using specific antagonists for these two receptors, we demonstrated that concomitant intracellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 180-183 purinergic receptor P2Y1 Homo sapiens 148-152 9647463-3 1998 However, the rP2Y4 receptor is not selective for uridine nucleotides and, instead, shows an agonist potency order of ITP = ATP = ADP(pure) = UTP = ATPgammaS = 2-MeSATP = Ap4A > UDP(pure). Adenosine Diphosphate 129-132 pyrimidinergic receptor P2Y4 Rattus norvegicus 13-18 20000380-5 2010 Strikingly, in contrast to the membrane-bound enzyme, the activity of the soluble chicken NTPDase8 decreased with time in a temperature-dependent manner as a result of inactivation by ATP, ADP, and P(i). Adenosine Diphosphate 189-192 ectonucleoside triphosphate diphosphohydrolase 8 Gallus gallus 90-98 20433309-11 2010 For the TRAP and the ADP agonists, the relative platelet activity decreased along the menstrual cycle from day 1 towards day 21 and from day 7 towards day 21, respectively, although differences reached statistical significance only for day 21 (-12.4% +/- 3.2%, P < 0.05 for TRAP, and -9.5% +/- 3.9%, P < 0.05 for ADP). Adenosine Diphosphate 319-322 TRAP Homo sapiens 8-12 19875982-4 2009 We show a nucleotide-dependent interaction between Hsp70 and alphaSyn, which leads to the aggregation of Hsp70, in the presence of ADP along with alphaSyn. Adenosine Diphosphate 131-134 heat shock protein family A (Hsp70) member 4 Homo sapiens 51-56 19875982-4 2009 We show a nucleotide-dependent interaction between Hsp70 and alphaSyn, which leads to the aggregation of Hsp70, in the presence of ADP along with alphaSyn. Adenosine Diphosphate 131-134 heat shock protein family A (Hsp70) member 4 Homo sapiens 105-110 20059376-8 2009 We demonstrate that ADP-Glo assay can be used for 2 kinase targets that belong to different classes, and compare the results of compound profiling with SPA and FP assay technologies. Adenosine Diphosphate 20-23 surfactant protein A2 Homo sapiens 152-155 19333785-3 2009 NTPDase2 and NTPDase3, which both prefer ATP over ADP as a substrate, are found in most nephron segments beyond the proximal tubule. Adenosine Diphosphate 50-53 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 0-8 19333785-3 2009 NTPDase2 and NTPDase3, which both prefer ATP over ADP as a substrate, are found in most nephron segments beyond the proximal tubule. Adenosine Diphosphate 50-53 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 13-21 19333785-4 2009 NPPs catalyse not only the hydrolysis of ATP and ADP, but also of diadenosine polyphosphates. Adenosine Diphosphate 49-52 ectonucleotide pyrophosphatase/phosphodiesterase 1 Rattus norvegicus 0-4 19675198-6 2009 All patients with SMAP showed an irreversible pattern of platelet microaggregates by a low dose of ADP. Adenosine Diphosphate 99-102 MBL associated serine protease 2 Homo sapiens 18-22 19695217-0 2009 STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets. Adenosine Diphosphate 56-59 ORAI calcium release-activated calcium modulator 1 Homo sapiens 7-12 19695217-0 2009 STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets. Adenosine Diphosphate 56-59 transient receptor potential cation channel subfamily C member 1 Homo sapiens 17-23 19713962-4 2009 Here, we show that the direct application of ATP, ADP and AMP in inside-out patch experiments potentiates the current mediated by ClC-5 with similar affinities. Adenosine Diphosphate 50-53 chloride voltage-gated channel 5 Homo sapiens 130-135 19583447-6 2009 It is suggested by model building that subunits n, n+4, and n+5 in the RecA filament contribute one loop each for holding the C-terminal domain of the repressor during cleavage within the RecA helical groove, explaining why its ADP-form is inactive and its ATP-form is active regarding repressor cleavage. Adenosine Diphosphate 228-231 RAD51 recombinase Homo sapiens 71-75 19583447-6 2009 It is suggested by model building that subunits n, n+4, and n+5 in the RecA filament contribute one loop each for holding the C-terminal domain of the repressor during cleavage within the RecA helical groove, explaining why its ADP-form is inactive and its ATP-form is active regarding repressor cleavage. Adenosine Diphosphate 228-231 RAD51 recombinase Homo sapiens 188-192 19481561-3 2009 Here we describe for the first time the isolation and functional characterization of a soluble phosphodiesterase from Bothrops jararaca venom, which shows amino acid sequence similarity to mammalian nucleotide pyrophosphatase/phosphodiesterase 3 (NPP3), and inhibits ADP-induced platelet aggregation. Adenosine Diphosphate 267-270 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 199-245 19481561-3 2009 Here we describe for the first time the isolation and functional characterization of a soluble phosphodiesterase from Bothrops jararaca venom, which shows amino acid sequence similarity to mammalian nucleotide pyrophosphatase/phosphodiesterase 3 (NPP3), and inhibits ADP-induced platelet aggregation. Adenosine Diphosphate 267-270 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 247-251 19285157-5 2009 We further investigated the mode of peptide interaction with the proteolytically inactive Lon mutant S679A in the absence and presence of ADP or AMPPNP by 2-dimensional nuclear magnetic resonance spectroscopy, and discovered that the binding interaction between protein and peptide varies with the nucleotide bound to the enzyme. Adenosine Diphosphate 138-141 putative ATP-dependent Lon protease Escherichia coli 90-93 19706470-4 2009 To elucidate a molecular mechanism for TA protein binding by Get3 we have determined three crystal structures in apo and ADP forms from Saccharomyces cerevisae (ScGet3-apo) and Aspergillus fumigatus (AfGet3-apo and AfGet3-ADP). Adenosine Diphosphate 121-124 guanine nucleotide exchange factor GET3 Saccharomyces cerevisiae S288C 61-65 19706858-10 2009 The rs12777823 polymorphism was in strong linkage disequilibrium with the CYP2C19*2 variant, and was associated with diminished clopidogrel response, accounting for 12% of the variation in platelet aggregation to ADP (P = 4.3 x 10(-11)). Adenosine Diphosphate 213-216 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 74-81 19345702-4 2009 AAP inhibited rabbit platelet aggregation induced by ADP, PAF-acether, collagen and thrombin, the IC(50)s were 178 microM, 332 microM, 179 microM and 203 microM, respectively. Adenosine Diphosphate 53-56 active avoidance performance Mus musculus 0-3 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 120-141 kinesin family member 2C Homo sapiens 49-53 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 120-141 kinesin family member 2C Homo sapiens 192-196 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 143-146 kinesin family member 2C Homo sapiens 49-53 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 143-146 kinesin family member 2C Homo sapiens 192-196 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 173-176 kinesin family member 2C Homo sapiens 49-53 19564401-6 2009 Detyrosination of MTs suppresses the activity of MCAK in vitro, apparently as the result of a decreased affinity of the adenosine diphosphate (ADP)-inorganic phosphate- and ADP-bound forms of MCAK for the MT lattice. Adenosine Diphosphate 173-176 kinesin family member 2C Homo sapiens 192-196 19450534-3 2009 Here, we show that yeast coronin (Crn1) makes a unique contribution to this process by differentially interacting with and regulating the effects of cofilin on ATP/ADP+P(i) versus ADP actin filaments. Adenosine Diphosphate 164-167 Crn1p Saccharomyces cerevisiae S288C 34-38 19450534-3 2009 Here, we show that yeast coronin (Crn1) makes a unique contribution to this process by differentially interacting with and regulating the effects of cofilin on ATP/ADP+P(i) versus ADP actin filaments. Adenosine Diphosphate 164-167 cofilin Saccharomyces cerevisiae S288C 149-156 19450534-4 2009 Crn1 potently blocks cofilin severing of newly assembled (ATP/ADP+P(i)) filaments but synergizes with cofilin to sever older (ADP) filaments. Adenosine Diphosphate 62-65 Crn1p Saccharomyces cerevisiae S288C 0-4 19407395-1 2009 Human ADP-ribosylhydrolase 1 (hARH1, ADPRH) cleaves the glycosidic bond of ADP-ribose attached to an Arg residue of a protein. Adenosine Diphosphate 6-9 ADP-ribosylarginine hydrolase Homo sapiens 30-35 19407395-2 2009 hARH1 has been cloned, expressed heterologously in Escherichia coli, purified and crystallized in complex with K(+) and ADP. Adenosine Diphosphate 120-123 ADP-ribosylarginine hydrolase Homo sapiens 0-5 9621261-6 1998 The energy charge was calculated as (ATP + 1/2 ADP)/(ATP + ADP + AMP). Adenosine Diphosphate 47-50 ATP synthase mitochondrial F1 complex assembly factor 2 Homo sapiens 37-46 9578557-0 1998 Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates. Adenosine Diphosphate 67-70 myosin heavy chain 14 Homo sapiens 14-20 9578557-14 1998 However, the rate of ADP release from the myosins, normally the slowest step involved in motility, was changed in a manner that reflects the activity of the donor myosin. Adenosine Diphosphate 21-24 myosin heavy chain 14 Homo sapiens 42-48 9558358-3 1998 MLCK activity was determined by measuring the rate of formation of one of the reaction products, ADP, in a coupled enzymatic assay by continuous fluorimetric monitoring of NADH removal in 100 microM CaCl2 at ionic strength 0.15 M, pH 7.0 and 21 degreesC. Adenosine Diphosphate 97-100 myosin light chain kinase Homo sapiens 0-4 9705078-7 1998 It is concluded that in insulin-producing cells with a high mitotic rate, inhibition of ADP-ribosylation--and consequently of auto-modification and release of PARP bound to DNA strand breaks--leads to activation of programmed cell death. Adenosine Diphosphate 88-91 poly (ADP-ribose) polymerase 1 Rattus norvegicus 159-163 9787764-10 1998 P-selectin is also be expressed on the surface of rabbit platelets activated by other agonists like ADP, A23817 and epinephrine. Adenosine Diphosphate 100-103 P-selectin Oryctolagus cuniculus 0-10 10684486-5 1998 Heparin increased PLT CD62 expression, which was significantly more pronounced in group 1 patients with plasma heparin levels less than 0.7 U/mL and ACT of 222 +/- 52 seconds compared with group 2 patients with heparin levels greater than 0.7 U/mL and ACT of 365 +/- 86 seconds (8 +/- 9 v -1 +/- 4% change in resulting PLTs, P =.01, and 11 +/- 12 v 1 +/- 6% increase in adenosine diphosphate (ADP) [5 microM]-stimulated PLTs, P =.02). Adenosine Diphosphate 370-391 selectin P Homo sapiens 22-26 10684486-5 1998 Heparin increased PLT CD62 expression, which was significantly more pronounced in group 1 patients with plasma heparin levels less than 0.7 U/mL and ACT of 222 +/- 52 seconds compared with group 2 patients with heparin levels greater than 0.7 U/mL and ACT of 365 +/- 86 seconds (8 +/- 9 v -1 +/- 4% change in resulting PLTs, P =.01, and 11 +/- 12 v 1 +/- 6% increase in adenosine diphosphate (ADP) [5 microM]-stimulated PLTs, P =.02). Adenosine Diphosphate 393-396 selectin P Homo sapiens 22-26 10684486-7 1998 A strong and statistically significant negative correlation between change in platelet CD62 expression and heparin concentration was observed in group 1 patients (r = -.5, P =.05, -ADP; r = -.65, P =.006, +ADP), whereas this relationship was weak and did not reach statistical significance in group 2 patients (r = -0.4, P =.2, -ADP; r =.11, P = 0.9; +ADP). Adenosine Diphosphate 181-184 selectin P Homo sapiens 87-91 10684486-7 1998 A strong and statistically significant negative correlation between change in platelet CD62 expression and heparin concentration was observed in group 1 patients (r = -.5, P =.05, -ADP; r = -.65, P =.006, +ADP), whereas this relationship was weak and did not reach statistical significance in group 2 patients (r = -0.4, P =.2, -ADP; r =.11, P = 0.9; +ADP). Adenosine Diphosphate 206-209 selectin P Homo sapiens 87-91 10684486-7 1998 A strong and statistically significant negative correlation between change in platelet CD62 expression and heparin concentration was observed in group 1 patients (r = -.5, P =.05, -ADP; r = -.65, P =.006, +ADP), whereas this relationship was weak and did not reach statistical significance in group 2 patients (r = -0.4, P =.2, -ADP; r =.11, P = 0.9; +ADP). Adenosine Diphosphate 206-209 selectin P Homo sapiens 87-91 10684486-7 1998 A strong and statistically significant negative correlation between change in platelet CD62 expression and heparin concentration was observed in group 1 patients (r = -.5, P =.05, -ADP; r = -.65, P =.006, +ADP), whereas this relationship was weak and did not reach statistical significance in group 2 patients (r = -0.4, P =.2, -ADP; r =.11, P = 0.9; +ADP). Adenosine Diphosphate 206-209 selectin P Homo sapiens 87-91 9546669-1 1998 Myosin forms stable ternary complexes with ADP and the phosphate analogues, fluoroaluminate (Al F4-), fluoroberyllate (BeFn) or orthovanadate (Vi); these ternary complexes mimic transient intermediates in the myosin ATPase cycle. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 0-6 9452498-7 1998 In assays of the binding of Hop to hsp70 and hsp90, Hop preferentially forms a complex with ADP-bound hsp70, and this process is unaffected by the presence of hsp90. Adenosine Diphosphate 92-95 homeodomain-only protein Oryctolagus cuniculus 28-31 9452498-7 1998 In assays of the binding of Hop to hsp70 and hsp90, Hop preferentially forms a complex with ADP-bound hsp70, and this process is unaffected by the presence of hsp90. Adenosine Diphosphate 92-95 homeodomain-only protein Oryctolagus cuniculus 52-55 9452498-9 1998 Hop also appears to bind to the ADP-bound form of hsp90, blocking the ATP-dependent conversion of hsp90 to a form capable of interacting with p23. Adenosine Diphosphate 32-35 homeodomain-only protein Oryctolagus cuniculus 0-3 9464249-1 1998 It has been proposed that platelets possess a P2X1-purinoceptor-like ligand-gated cation channel, through which Ca2+ enters platelets from the extracellular medium upon ADP or ATP stimulation. Adenosine Diphosphate 169-172 purinergic receptor P2X 1 Homo sapiens 46-50 16793705-6 1998 In contrast stirring-induced as well as ADP-induced increase of P-selectin exposure (33 and 107% , respectively) was not affected by FMLP. Adenosine Diphosphate 40-43 selectin P Homo sapiens 64-74 9428522-4 1997 The hMSH2-hMSH6 complex is ON (binds mismatched nucleotides) in the ADP-bound form and OFF in the ATP-bound form. Adenosine Diphosphate 68-71 mutS homolog 6 Homo sapiens 10-15 9474751-9 1997 We find that the interaction of TNP-ADP with IAF-labelled Na+/K(+)-ATPase is best described by a model in which there are two classes of binding: TNP-ADP and ADP compete for a specific binding site with dissociation binding constants of 0.13 microM for TNP-ADP and 2.0 microM for ADP; and non-saturable non-specific binding of TNP-ADP. Adenosine Diphosphate 36-39 transition protein 2 Homo sapiens 253-266 9474751-9 1997 We find that the interaction of TNP-ADP with IAF-labelled Na+/K(+)-ATPase is best described by a model in which there are two classes of binding: TNP-ADP and ADP compete for a specific binding site with dissociation binding constants of 0.13 microM for TNP-ADP and 2.0 microM for ADP; and non-saturable non-specific binding of TNP-ADP. Adenosine Diphosphate 150-153 transition protein 2 Homo sapiens 253-266 9295332-0 1997 The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. Adenosine Diphosphate 93-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 52-57 9295332-0 1997 The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation. Adenosine Diphosphate 93-96 heat shock protein 90 alpha family class A member 1 Homo sapiens 126-131 9309698-2 1997 We found a lowered ANT transport capacity of the adenine nucleotide translocator (ANT), the only transport system for ATP and ADP in eucaryotic cells, in explanted hearts of DCM patients. Adenosine Diphosphate 126-129 solute carrier family 25 member 6 Homo sapiens 19-22 19381014-2 2009 The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP to suppress platelet accumulation in the ischemic brain. Adenosine Diphosphate 72-75 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 15-19 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 18282622-4 2009 Platelet reactivity was assessed by ADP-induced aggregation and activation was measured by p-selectin, total and active GPIIb/IIIa expression, and platelet-leukocyte aggregates in. Adenosine Diphosphate 36-39 integrin subunit alpha 2b Homo sapiens 120-125 9309698-2 1997 We found a lowered ANT transport capacity of the adenine nucleotide translocator (ANT), the only transport system for ATP and ADP in eucaryotic cells, in explanted hearts of DCM patients. Adenosine Diphosphate 126-129 solute carrier family 25 member 6 Homo sapiens 49-80 9309698-2 1997 We found a lowered ANT transport capacity of the adenine nucleotide translocator (ANT), the only transport system for ATP and ADP in eucaryotic cells, in explanted hearts of DCM patients. Adenosine Diphosphate 126-129 solute carrier family 25 member 6 Homo sapiens 82-85 9256426-3 1997 In the presence of ADP, one molecule of hsp10 binds to hsp60 with an apparent Kd of 0.9 nM and a second molecule of hsp10 binds with a Kd of 24 nM. Adenosine Diphosphate 19-22 Hsp10p Saccharomyces cerevisiae S288C 40-45 19143920-4 2009 METHODS AND RESULTS: Via selective interaction with activated platelets through GPIIb/IIIa, H12-(ADP)-liposomes were capable of augmenting agonist-induced platelet aggregation by releasing ADP in an aggregation-dependent manner. Adenosine Diphosphate 96-100 integrin alpha-IIb Oryctolagus cuniculus 80-85 19143920-4 2009 METHODS AND RESULTS: Via selective interaction with activated platelets through GPIIb/IIIa, H12-(ADP)-liposomes were capable of augmenting agonist-induced platelet aggregation by releasing ADP in an aggregation-dependent manner. Adenosine Diphosphate 97-100 integrin alpha-IIb Oryctolagus cuniculus 80-85 19154428-10 2009 MRS 2179 facilitated evoked [(3)H]ACh release, an effect reversed by the ecto-ATPase inhibitor, ARL67156, which delayed ATP conversion into ADP without affecting adenosine levels. Adenosine Diphosphate 140-143 CEA cell adhesion molecule 1 Rattus norvegicus 73-84 9256426-3 1997 In the presence of ADP, one molecule of hsp10 binds to hsp60 with an apparent Kd of 0.9 nM and a second molecule of hsp10 binds with a Kd of 24 nM. Adenosine Diphosphate 19-22 chaperone ATPase HSP60 Saccharomyces cerevisiae S288C 55-60 19154428-13 2009 Stimulation of inhibitory P2Y(1) receptors by ADP generated alternatively via ecto-ATPase might be relevant in restraining ACh exocytosis when ATP saturates ecto-ATPDase activity. Adenosine Diphosphate 46-49 CEA cell adhesion molecule 1 Rattus norvegicus 78-89 9256426-3 1997 In the presence of ADP, one molecule of hsp10 binds to hsp60 with an apparent Kd of 0.9 nM and a second molecule of hsp10 binds with a Kd of 24 nM. Adenosine Diphosphate 19-22 Hsp10p Saccharomyces cerevisiae S288C 116-121 9230303-0 1997 Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone. Adenosine Diphosphate 58-61 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 82-87 19143839-3 2009 Here, we describe an apparent ADP hydrolysis by highly purified preparations of the AAA+ ATPase NtrC1 from an extremely thermophilic bacterium, Aquifex aeolicus. Adenosine Diphosphate 30-33 ATPase Escherichia coli 89-95 19143839-5 2009 AK catalyzes conversion of two molecules of ADP into AMP and ATP, the latter being a substrate for the ATPase. Adenosine Diphosphate 44-47 ATPase Escherichia coli 103-109 19143839-7 2009 For example, contamination with E. coli AK may be responsible for reported ADPase activities of the ATPase chaperonins from Pyrococcus furiosus, Pyrococcus horikoshii, Methanococcus jannaschii and Thermoplasma acidophilum; the ATP/ADP-dependent DNA ligases from Aeropyrum pernix K1 and Staphylothermus marinus; or the reported ATP-dependent activities of ADP-dependent phosphofructokinase of P. furiosus. Adenosine Diphosphate 75-78 ATPase Escherichia coli 100-106 9230303-3 1997 Crystal structures of complexes between the N-terminal domain of the yeast Hsp90 chaperone and ADP/ATP unambiguously identify a specific adenine nucleotide binding site homologous to the ATP-binding site of DNA gyrase B. Adenosine Diphosphate 95-98 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 75-80 19143839-7 2009 For example, contamination with E. coli AK may be responsible for reported ADPase activities of the ATPase chaperonins from Pyrococcus furiosus, Pyrococcus horikoshii, Methanococcus jannaschii and Thermoplasma acidophilum; the ATP/ADP-dependent DNA ligases from Aeropyrum pernix K1 and Staphylothermus marinus; or the reported ATP-dependent activities of ADP-dependent phosphofructokinase of P. furiosus. Adenosine Diphosphate 231-234 ATPase Escherichia coli 100-106 9249247-27 1997 Endothelium-dependent, NO-dependent, vasodilatation to 2MeSATP and ADP may be mediated by P2Y1 receptors, while endothelial P2Y2 receptors are likely to mediate NO-dependent relaxation to ATP and UTP. Adenosine Diphosphate 67-70 purinergic receptor P2Y1 Homo sapiens 90-94 19177562-8 2009 Interestingly, the noncanonical Walker A sequence in ClpB induced preferential binding of ADP vs. ATP and uncoupled the linkage between the ATP-bound conformation and the high-affinity binding to protein aggregates. Adenosine Diphosphate 90-93 caseinolytic mitochondrial matrix peptidase chaperone subunit B Homo sapiens 53-57 9217172-8 1997 In addition, thrombin- and ADP-induced expression of CD62P and CD63 was defective in WAS platelets. Adenosine Diphosphate 27-30 selectin P Homo sapiens 53-58 18486134-7 2009 RESULTS: We documented a significant association between IP-10, IFN-gamma, IL-4 and RPR by both AA- and ADP-induced platelet aggregation after adjustment for age, sex, cardiovascular risk factors, ejection fraction, BMI, vWF and CRP. Adenosine Diphosphate 104-107 C-X-C motif chemokine ligand 10 Homo sapiens 57-62 9217172-8 1997 In addition, thrombin- and ADP-induced expression of CD62P and CD63 was defective in WAS platelets. Adenosine Diphosphate 27-30 CD63 molecule Homo sapiens 63-67 9113997-8 1997 Because ATP reacts rapidly with the myosin head (M) to form the complex (M. ADP.Pi) with an average lifetime of >10 s, the observed myosin head movement may be mostly associated with reaction, M + ATP --> M.ADP. Adenosine Diphosphate 76-79 myosin heavy chain 14 Homo sapiens 36-42 18678871-6 2008 These findings show that the covalent FAD-protein linkage can be formed autocatalytically and hint to a new-found rationale for covalent flavinylation: covalent flavinylation may have evolved to prevent binding of ADP or related cellular compounds, which would prohibit formation of flavinylated and functional enzyme. Adenosine Diphosphate 214-217 BRCA2 DNA repair associated Homo sapiens 38-41 18684711-2 2008 Conversely, various nucleotide exchange factors (NEFs) stimulate ADP-ATP exchange by Hsc70. Adenosine Diphosphate 65-68 heat shock protein family A (Hsp70) member 8 Homo sapiens 85-90 18715989-7 2008 Shear-induced response at the Syk 525/526 site was ADP dependent but not contingent on glycoprotein (GP) IIb-IIIa ligation or the generation of thromboxane (Tx) A(2). Adenosine Diphosphate 51-54 spleen associated tyrosine kinase Homo sapiens 30-33 9113997-8 1997 Because ATP reacts rapidly with the myosin head (M) to form the complex (M. ADP.Pi) with an average lifetime of >10 s, the observed myosin head movement may be mostly associated with reaction, M + ATP --> M.ADP. Adenosine Diphosphate 213-216 myosin heavy chain 14 Homo sapiens 36-42 9099753-9 1997 Stimulation of platelets by several agonists such as collagen, ADP, epinephrine, and calcium ionophore A23187 induced RAFTK phosphorylation. Adenosine Diphosphate 63-66 protein tyrosine kinase 2 beta Homo sapiens 118-123 18510943-10 2008 The isolation of intact AAC as a first for any transporter enabled the reconstitution of transport for unravelling, independently of mitochondrial complications, the factors controlling the ADP/ATP exchange. Adenosine Diphosphate 190-193 glycine-N-acyltransferase Homo sapiens 24-27 18510943-14 2008 Mutations served to elucidate the function of residues, including the particular sensitivity of ATP versus ADP transport to deletion of critical positive charge in AAC. Adenosine Diphosphate 107-110 glycine-N-acyltransferase Homo sapiens 164-167 9155010-3 1997 The ADP conformation of mhsp70 favors formation of a complex on the inner membrane; this "import complex" contains mhsp70, its membrane anchor Tim44 and the nucleotide exchange factor mGrpE. Adenosine Diphosphate 4-7 translocase of inner mitochondrial membrane 44 Homo sapiens 143-148 18649393-5 2008 P2Y receptor agonists (ADP and 2MeS-ADP) but not a P2X receptor agonist (alphabetaMeATP) induced the expression of BDNF exon IV mRNA. Adenosine Diphosphate 23-26 brain-derived neurotrophic factor Rattus norvegicus 115-119 18680554-6 2008 These results suggest that LPA induces the release of ATP from rat primary cultured microglia via the LPA(3) receptor, Galpha(q/11) and PLC, and that the released ATP or ectopically converted ADP may in turn cause membrane ruffling via P2Y(12) receptors and Galpha(i/o) activation, and BDNF expression via activation of P2X(4) receptors. Adenosine Diphosphate 192-195 brain-derived neurotrophic factor Rattus norvegicus 286-290 9077545-17 1997 We established the role of CD39 as a prime endothelial thromboregulator by demonstrating that CD39-transfected COS cells acquired the ability to inhibit ADP-induced aggregation in platelet-rich plasma. Adenosine Diphosphate 153-156 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 27-31 18665919-4 2008 RESULTS: Treatment of platelets with thrombin or ADP induces activation and mitochondrial association of active Bid, Bax and Bak. Adenosine Diphosphate 49-52 BCL2 antagonist/killer 1 Homo sapiens 125-128 18841285-4 2008 After stimulation with 20 muM ADP, 2 hours after LD, significantly lower expression of activated GPIIb/IIIa (4.3 vs. 21.8 [mean fluorescent intensity (MFI)], p < 0.001) and P-selectin (2.0 vs. 11.7 MFI, p < 0.001) along with decreased formation of platelet-monocyte aggregates (16.4% vs. 29.6% positive cells, p < 0.001) was observed with prasugrel versus clopidogrel. Adenosine Diphosphate 30-33 integrin subunit alpha 2b Homo sapiens 97-102 9077545-17 1997 We established the role of CD39 as a prime endothelial thromboregulator by demonstrating that CD39-transfected COS cells acquired the ability to inhibit ADP-induced aggregation in platelet-rich plasma. Adenosine Diphosphate 153-156 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 94-98 9045625-2 1997 Auxilin caused a 5-fold increase in Hsc70 ATPase activity and a corresponding increase in steady-state levels of bound ADP; the dissociation constant for this effect was 0.6 microM. Adenosine Diphosphate 119-122 DnaJ heat shock protein family (Hsp40) member C6 Homo sapiens 0-7 18386050-7 2008 Dissociation of rTnC after addition of Pi or MgADP to form A.M.Pi or A.M.ADP cross-bridges was significantly greater than with rigor (A.M) bridges. Adenosine Diphosphate 45-50 tenascin C Rattus norvegicus 16-20 18386050-7 2008 Dissociation of rTnC after addition of Pi or MgADP to form A.M.Pi or A.M.ADP cross-bridges was significantly greater than with rigor (A.M) bridges. Adenosine Diphosphate 47-50 tenascin C Rattus norvegicus 16-20 18386050-8 2008 The increase in P (o) during equilibration with different concentrations of rTnC showed that the affinity for rTnC binding to the thin filament increased progressively with stronger cross-bridges: rTnC concentrations for half-maximal reconstitution (K (0.5)) were 8.1, 3.7, 2.9, and 1.1 microM for A + M.ADP.Pi, A.M.Pi, A.M, and A.M + S1. Adenosine Diphosphate 304-307 tenascin C Rattus norvegicus 76-80 18386050-8 2008 The increase in P (o) during equilibration with different concentrations of rTnC showed that the affinity for rTnC binding to the thin filament increased progressively with stronger cross-bridges: rTnC concentrations for half-maximal reconstitution (K (0.5)) were 8.1, 3.7, 2.9, and 1.1 microM for A + M.ADP.Pi, A.M.Pi, A.M, and A.M + S1. Adenosine Diphosphate 304-307 tenascin C Rattus norvegicus 110-114 18386050-8 2008 The increase in P (o) during equilibration with different concentrations of rTnC showed that the affinity for rTnC binding to the thin filament increased progressively with stronger cross-bridges: rTnC concentrations for half-maximal reconstitution (K (0.5)) were 8.1, 3.7, 2.9, and 1.1 microM for A + M.ADP.Pi, A.M.Pi, A.M, and A.M + S1. Adenosine Diphosphate 304-307 tenascin C Rattus norvegicus 110-114 18567585-7 2008 Furthermore, we showed that ADP prevents the association of ATP to the trans-ring of GroEL, and as a consequence, the second GroES cannot bind to GroEL. Adenosine Diphosphate 28-31 chaperonin GroES Escherichia coli 125-130 9421132-2 1997 Ecto-apyrase is a widespread enzymatic activity that hydrolyses tri- and diphosphonucleotides and consequently controls the amount of available extracellular ATP and ADP. Adenosine Diphosphate 166-169 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-12 18718422-6 2008 Patients in the upper tertile displayed greater platelet aggregation to 5-mumol/l adenosine diphosphate (ADP) (50.7 +/- 16.4% vs. 34.2 +/- 17.3%, p < 0.001), 1.5-mmol/l arachidonic acid (AA) (27.3 +/- 16.9% vs. 11.7 +/- 9.3%, p < 0.001), and 1-mug/ml collagen (18 +/- 11.6% vs. 12.1 +/- 8.7%, p < 0.05) and greater expression of GP IIb/IIIa (4.7 +/- 1.8% vs. 3.1 +/- 2.2%, p < 0.001). Adenosine Diphosphate 105-108 integrin subunit alpha 2b Homo sapiens 338-344 9127326-9 1997 The phenomenon was duplicated in vitro when ADP-activated normal platelets were incubated with neutrophil cells but was largely inhibited when ADP-activated platelets were treated with anti-P-selectin antibody before incubation with neutrophils. Adenosine Diphosphate 44-47 selectin P Homo sapiens 190-200 18346178-0 2008 Inhibition of ADP-induced platelet aggregation by clopidogrel is related to CYP2C19 genetic polymorphisms. Adenosine Diphosphate 14-17 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 76-83 9067995-3 1997 The amount of rho p21 in cells or tissues is determined by the in vitro ADP-ribosylation reaction with C3 exoenzyme and 32P NAD. Adenosine Diphosphate 72-75 H3 histone pseudogene 16 Homo sapiens 18-21 18346178-3 2008 The aim of the present study was to evaluate the contribution of CYP2C19 genetic polymorphisms to the inhibition of ADP-induced platelet aggregation by clopidogrel in healthy Chinese volunteers. Adenosine Diphosphate 116-119 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 65-72 18346178-9 2008 There were significant decrease in 2 and 5 micromol/L ADP-induced platelet aggregation at 4, 24 and 72 h after clopidogrel among the three CYP2C19 genotypes compared with baseline (P < 0.001). Adenosine Diphosphate 54-57 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 139-146 18346178-10 2008 The change in 5 micromol/L ADP-induced platelet aggregation in subjects with the CYP2C19*1/CYP2C19*1 genotype was greater than that in subjects with the CYP2C19*2/CYP2C19*2and*3 genotype at 4 h (49.0 +/- 15.5 vs 29.7 +/- 17.4%, respectively; P = 0.029), 24 h (48.7 +/- 20.5 vs 25.0 +/- 17.6%, respectively; P = 0.035) and 72 h (45.5 +/- 15.2 vs 26.5 +/- 15.8%, respectively; P = 0.030) after clopidogrel administration. Adenosine Diphosphate 27-30 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 81-88 18346178-10 2008 The change in 5 micromol/L ADP-induced platelet aggregation in subjects with the CYP2C19*1/CYP2C19*1 genotype was greater than that in subjects with the CYP2C19*2/CYP2C19*2and*3 genotype at 4 h (49.0 +/- 15.5 vs 29.7 +/- 17.4%, respectively; P = 0.029), 24 h (48.7 +/- 20.5 vs 25.0 +/- 17.6%, respectively; P = 0.035) and 72 h (45.5 +/- 15.2 vs 26.5 +/- 15.8%, respectively; P = 0.030) after clopidogrel administration. Adenosine Diphosphate 27-30 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 91-98 18346178-10 2008 The change in 5 micromol/L ADP-induced platelet aggregation in subjects with the CYP2C19*1/CYP2C19*1 genotype was greater than that in subjects with the CYP2C19*2/CYP2C19*2and*3 genotype at 4 h (49.0 +/- 15.5 vs 29.7 +/- 17.4%, respectively; P = 0.029), 24 h (48.7 +/- 20.5 vs 25.0 +/- 17.6%, respectively; P = 0.035) and 72 h (45.5 +/- 15.2 vs 26.5 +/- 15.8%, respectively; P = 0.030) after clopidogrel administration. Adenosine Diphosphate 27-30 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 91-98 18346178-10 2008 The change in 5 micromol/L ADP-induced platelet aggregation in subjects with the CYP2C19*1/CYP2C19*1 genotype was greater than that in subjects with the CYP2C19*2/CYP2C19*2and*3 genotype at 4 h (49.0 +/- 15.5 vs 29.7 +/- 17.4%, respectively; P = 0.029), 24 h (48.7 +/- 20.5 vs 25.0 +/- 17.6%, respectively; P = 0.035) and 72 h (45.5 +/- 15.2 vs 26.5 +/- 15.8%, respectively; P = 0.030) after clopidogrel administration. Adenosine Diphosphate 27-30 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 91-98 18346178-12 2008 In conclusion, CYP2C19*2 and CYP2C19*3 genetic polymorphisms reduced clopidogrel inhibition of ADP-induced platelet aggregation, with the degree of inhition dependent on the genetic polymorphism present. Adenosine Diphosphate 95-98 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 15-22 18346178-12 2008 In conclusion, CYP2C19*2 and CYP2C19*3 genetic polymorphisms reduced clopidogrel inhibition of ADP-induced platelet aggregation, with the degree of inhition dependent on the genetic polymorphism present. Adenosine Diphosphate 95-98 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 29-36 18562646-3 2008 Compared to Aac2, Aac1 exhibited reduced capacity to support growth of yeast lacking mitochondrial DNA or of yeast lacking the ATP/Mg-P(i) carrier, both conditions requiring ATP import into the mitochondrial matrix through the ADP/ATP carrier. Adenosine Diphosphate 227-230 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 18-22 18562646-5 2008 On the basis of the growth rate differences of yeast expressing different chimeras, the C1 and M2 loops of the ADP/ATP carriers contain divergent residues that are responsible for the difference(s) between Aac1 and Aac2. Adenosine Diphosphate 111-114 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 206-210 9062701-2 1996 The apparent K(m) value for ADP with succinate as substrate, which was as high as 330 +/- 32 microM in SF in SF at 20 degrees C, decreased about 2-fold in SCF at the same temperature and in SF at 37 degrees C, and decreased further to 67 +/- 8 microM in SCF at 37 degrees C. Thus, weakening or breaking of cellular contacts by collagenase and the temperature-dependence of diffusion of substrates such as ADP, seem to be important factors that determine the respiratory activity and regulatory parameters of mitochondria in saponin-permeabilized cardiomyocytes. Adenosine Diphosphate 28-31 KIT ligand Rattus norvegicus 155-158 18377927-5 2008 To unravel the structural basis for substrate promiscuity of dCK at both the nucleoside acceptor and nucleotide donor sites, we solved the crystal structures of the enzyme as ternary complexes with the two enantiomeric forms of dA (D-dA, or L-dA), with either UDP or ADP bound to the donor site. Adenosine Diphosphate 267-270 sticky Drosophila melanogaster 61-64 18386218-2 2008 METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI). Adenosine Diphosphate 166-187 nitric oxide synthase 3 Rattus norvegicus 96-129 18386218-2 2008 METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI). Adenosine Diphosphate 166-187 nitric oxide synthase 3 Rattus norvegicus 131-135 18386218-2 2008 METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI). Adenosine Diphosphate 189-192 nitric oxide synthase 3 Rattus norvegicus 96-129 18386218-2 2008 METHODS: We examined the reactivity of cerebral arterioles in adult and aged Fisher-344 rats to endothelial nitric oxide synthase (eNOS)-dependent (acetylcholine and adenosine diphosphate [ADP]) and-independent (nitroglycerin) agonists before and during application of tempol, apocynin, and diphenyleneiodonium chloride (DPI). Adenosine Diphosphate 189-192 nitric oxide synthase 3 Rattus norvegicus 131-135 9062701-2 1996 The apparent K(m) value for ADP with succinate as substrate, which was as high as 330 +/- 32 microM in SF in SF at 20 degrees C, decreased about 2-fold in SCF at the same temperature and in SF at 37 degrees C, and decreased further to 67 +/- 8 microM in SCF at 37 degrees C. Thus, weakening or breaking of cellular contacts by collagenase and the temperature-dependence of diffusion of substrates such as ADP, seem to be important factors that determine the respiratory activity and regulatory parameters of mitochondria in saponin-permeabilized cardiomyocytes. Adenosine Diphosphate 28-31 KIT ligand Rattus norvegicus 254-257 9062701-2 1996 The apparent K(m) value for ADP with succinate as substrate, which was as high as 330 +/- 32 microM in SF in SF at 20 degrees C, decreased about 2-fold in SCF at the same temperature and in SF at 37 degrees C, and decreased further to 67 +/- 8 microM in SCF at 37 degrees C. Thus, weakening or breaking of cellular contacts by collagenase and the temperature-dependence of diffusion of substrates such as ADP, seem to be important factors that determine the respiratory activity and regulatory parameters of mitochondria in saponin-permeabilized cardiomyocytes. Adenosine Diphosphate 405-408 KIT ligand Rattus norvegicus 155-158 18396434-5 2008 Importantly, down-regulation of PARP expression after infection abrogated the ADP-ribosylation of acceptor proteins in response to oxidative stress. Adenosine Diphosphate 78-81 poly (ADP-ribose) polymerase family, member 1 Mus musculus 32-36 8939938-7 1996 ADP protected each of the cysteine residues from modification and protected Ssa1p from inactivation. Adenosine Diphosphate 0-3 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 76-81 8947491-10 1996 These results provide direct evidence for the involvement of p42 and p44 MAPK in the PGI2 response of intact endothelial cells: we have shown that both the endothelial P2Y purinoceptors are linked to activation of MAPK, and that activation of this pathway is a requirement for the stimulation by ATP/ADP of endothelial PGI2 production. Adenosine Diphosphate 300-303 cyclin dependent kinase 20 Homo sapiens 61-64 18657307-7 2008 Aggregation studies showed that platelets carrying the Pl(A2) allele were hypersensitive to the platelet aggregating agonists ADP and collagen and produced a higher amount of TXA(2) when stimulated with low concentrations of both these agonists. Adenosine Diphosphate 126-129 phospholipase A2 group IIA Homo sapiens 55-60 17963730-3 2007 On MT binding and in the presence of nucleotides ADP and AMPPNP, the spin labels on L11, particularly at A252C and L249C, significantly decreased the fraction of the slow component. Adenosine Diphosphate 49-52 immunoglobulin kappa variable 1-6 Homo sapiens 84-87 17964276-7 2007 However, nucleotide inhibition of PP1c by ATP, ADP and AMP was much weaker at 5 degrees C compared with 37 degrees C assay temperatures. Adenosine Diphosphate 47-50 protein phosphatase 1 catalytic subunit gamma Homo sapiens 34-38 8950023-1 1996 The thermal unfolding of the myosin subfragment 1 (S1) and of filamentous actin (F-actin) in their strong complex obtained in the presence of ADP was studied by differential scanning calorimetry (DSC). Adenosine Diphosphate 142-145 myosin heavy chain 14 Homo sapiens 29-35 18084067-2 2007 The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Adenosine Diphosphate 98-101 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 18-21 18084067-2 2007 The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Adenosine Diphosphate 98-101 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 56-59 17883592-8 2007 Stimulation of PAR1 or PAR4 resulted in rapid Akt phosphorylation, independently of secreted ADP and phosphatidylinositol-3-kinase (PI3K) activation. Adenosine Diphosphate 93-96 F2R like thrombin or trypsin receptor 3 Homo sapiens 23-27 8873343-3 1996 ADP-induced P-selectin expression and platelet-leukocyte adhesion was also enhanced in the patient group (p < 0.05). Adenosine Diphosphate 0-3 selectin P Homo sapiens 12-22 17855752-5 2007 Here we examine rundown and MgADP activation of wild-type and Kir6.2-F333I/SUR2A channels using single-channel recording, noise analysis and spectral analysis. Adenosine Diphosphate 28-33 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 62-68 17855752-7 2007 All three approaches indicated that rundown of Kir6.2-F333I/SUR2A channels is due to a reduction in the number of active channels in the patch and that MgADP reactivation involves recruitment of inactive channels. Adenosine Diphosphate 152-157 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 47-53 17855752-8 2007 In contrast, rundown and MgADP reactivation of wild-type and Kir6.2-G334D/SUR2A channels, and of Kir6.2-F333I/SUR1 channels, involve a gradual change in P(o). Adenosine Diphosphate 25-30 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 61-67 17855752-8 2007 In contrast, rundown and MgADP reactivation of wild-type and Kir6.2-G334D/SUR2A channels, and of Kir6.2-F333I/SUR1 channels, involve a gradual change in P(o). Adenosine Diphosphate 25-30 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 97-103 17855752-9 2007 Our results suggest that F333 in Kir6.2 interacts functionally with SUR2A to modulate channel rundown and MgADP activation. Adenosine Diphosphate 106-111 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 33-39 8701947-8 1996 Upon incubation of platelets with ADP (2-10 microM), the mean fluorescence intensity due to P-selectin was < 14% of that induced by SFLLRN. Adenosine Diphosphate 34-37 selectin P Homo sapiens 92-102 8759907-4 1996 A challenge test of G-CSF showed an increase in the platelet count and an augmentation of ADP- and collagen-induced platelet aggregation. Adenosine Diphosphate 90-93 colony stimulating factor 3 Homo sapiens 20-25 17473221-2 2007 By hydrolyzing ATP and ADP to AMP, ENTPD1 regulates ligand availability to a large family of P2 (purinergic) receptors. Adenosine Diphosphate 23-26 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 35-41 17473221-8 2007 Mesangial cell PAI-1 and MCP-1 mRNA expression were upregulated by ATP and UTP but not ADP or adenosine in vitro. Adenosine Diphosphate 87-90 chemokine (C-C motif) ligand 2 Mus musculus 25-30 17526733-1 2007 Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal Gs protein (Gsalpha), leading to characteristic water and electrolyte losses. Adenosine Diphosphate 108-111 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 176-183 17526733-3 2007 We hypothesized that ADPRH might counteract intoxication by reversing the ADP-ribosylation of Gsalpha. Adenosine Diphosphate 21-24 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 94-101 17602871-7 2007 Flow cytometric analysis revealed minor changes in CD41 expression after ADP on the 3rd day compared to 1st day and on the 5th day compared to 3rd day. Adenosine Diphosphate 73-76 integrin subunit alpha 2b Homo sapiens 51-55 17381624-9 2007 Correspondingly, a reduced capacity for up regulation of CD62P expression and down regulation of CD42b was observed in PCT PLTs after stimulation by the agonists ADP or TRAP. Adenosine Diphosphate 162-165 glycoprotein Ib platelet subunit alpha Homo sapiens 97-102 8700127-12 1996 The data indicate that the P2Y2 receptor is activated with similar potencies by ATP and UTP but not by ADP or UDP; the P2Y6 receptor is activated most potently by UDP but weakly by UTP, ATP, and ADP; and the P2Y4 receptor is activated most potently by UTP, less potently by ATP, and not at all by nucleotide diphosphates. Adenosine Diphosphate 195-198 pyrimidinergic receptor P2Y6 Homo sapiens 119-123 17264076-9 2007 The inhibitors ADP and staurosporine were both found to be competitive with ATP and non-competitive with S1, indicating binding of ATP and S1 to BTK is either random or ordered with ATP binding first. Adenosine Diphosphate 15-18 Bruton tyrosine kinase Homo sapiens 145-148 8639641-11 1996 CAS reduction confers resistance not only to the ADP-ribosylating toxins PE and DT, but also to tumor necrosis factor alpha and beta. Adenosine Diphosphate 49-52 chromosome segregation 1 like Homo sapiens 0-3 17410649-3 2007 carnosic acid significantly inhibited collagen-, arachidonic acid-, U46619- and thrombin-induced washed rabbit platelet aggregation in a concentration-dependent manner, with IC50 values of 39+/-0.3, 34+/-1.8, 29+/-0.8 and 48+/-2.9 microM, respectively, while it failed to inhibit PMA-(a direct PKC activator) and ADP-induced platelet aggregation. Adenosine Diphosphate 313-316 prothrombin Oryctolagus cuniculus 80-88 8813602-4 1996 In contrast, P2 purinoceptor agonists produced similar outward currents with the order of potency: ADP > or = 2-methylthio ATP > ATP > adenosine >> AMP. Adenosine Diphosphate 99-102 pyrimidinergic receptor P2Y6 Homo sapiens 13-28 16720618-2 2006 In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabolites, including cyclic adenosine diphosphate ribose (cADPR). Adenosine Diphosphate 148-169 CD38 antigen Mus musculus 47-51 8670200-7 1996 In 1321N1 cells stably expressing the human P2Y6 receptor, the formation of IP3 was stimulated by nucleotides with the following order of potency: UDP > 5-bromo-UPT > UTP > ADP > 2-methylthio-ATP >> ATP. Adenosine Diphosphate 182-185 pyrimidinergic receptor P2Y6 Homo sapiens 44-57 8617367-4 1996 The identification of a pancreas-specific human putative P2 purinoceptor makes it attractive to speculate that the reported actions of ADP/ATP analogues in pancreas on insulin secretion are mediated through this receptor. Adenosine Diphosphate 135-138 pyrimidinergic receptor P2Y6 Homo sapiens 57-72 8609401-0 1996 Regulation of CTL by ecto-nictinamide adenine dinucleotide (NAD) involves ADP-ribosylation of a p56lck-associated protein. Adenosine Diphosphate 74-77 LCK proto-oncogene, Src family tyrosine kinase Homo sapiens 96-102 8627219-2 1996 Both forms of HBx, after purification, displayed a potent AMP kinase activity, in which HBx phosphorylates AMP to ADP, using ATP as the exclusive phosphate donor. Adenosine Diphosphate 114-117 X protein Hepatitis B virus 14-17 8627219-2 1996 Both forms of HBx, after purification, displayed a potent AMP kinase activity, in which HBx phosphorylates AMP to ADP, using ATP as the exclusive phosphate donor. Adenosine Diphosphate 114-117 X protein Hepatitis B virus 88-91 8740431-3 1996 During shortening at low speed, as well as after a shortening step of moderate size, phosphate release from the cross-bridge in the AM-ADP-P state promotes a 100 s-1 structural change which resets the myosin head in a configuration that allows for a new complete working stroke in the AM-ADP state. Adenosine Diphosphate 135-138 myosin heavy chain 14 Homo sapiens 201-207 16526943-6 2006 In fact, PARG-silenced cells were more resistant than their wild-type counterparts to oxidant-induced apoptosis while exhibiting delayed PAR degradation and transient accumulation of ADP-ribose polymers longer than 15-mers at early stages of drug treatment. Adenosine Diphosphate 183-186 poly (ADP-ribose) glycohydrolase Mus musculus 9-13 8740431-3 1996 During shortening at low speed, as well as after a shortening step of moderate size, phosphate release from the cross-bridge in the AM-ADP-P state promotes a 100 s-1 structural change which resets the myosin head in a configuration that allows for a new complete working stroke in the AM-ADP state. Adenosine Diphosphate 288-291 myosin heavy chain 14 Homo sapiens 201-207 16584705-8 2006 In addition, we demonstrate that ADP competitively inhibits phosphorylation of HDAC5 (K(i)=8.50, 17.54, and 11.98microM for PKD1, PKD2, and PKD3, respectively). Adenosine Diphosphate 33-36 PKD3 Homo sapiens 140-144 8570612-2 1996 Here we report that the electrical nature of the ADP/ATP exchange by the mitochondrial ADP/ATP carrier (AAC) can be directly studied by measuring the electrical currents via capacitive coupling of AAC-containing vesicles on a planar lipid membrane. Adenosine Diphosphate 49-52 WD and tetratricopeptide repeats 1 Homo sapiens 87-102 16624636-4 2006 In contrast, > 0.5 mM Mg2+ was required to saturate hRAD51 with ADP. Adenosine Diphosphate 67-70 RAD51 recombinase Homo sapiens 55-61 16624636-5 2006 We found ADP to be a significantly less effective competitive inhibitor of the hRAD51 ATPase at low Mg2+ concentrations (0.08 mM). Adenosine Diphosphate 9-12 RAD51 recombinase Homo sapiens 79-85 16624636-9 2006 There was a strong correlation between the amount of Mg2+ required for stable ADP binding and the inhibition of hRad51 strand exchange activity. Adenosine Diphosphate 78-81 RAD51 recombinase Homo sapiens 112-118 8714460-0 1996 [Calorimetric study of stable complexes of myosin subfragment I with adenosine diphosphate and phosphate analogs]. Adenosine Diphosphate 69-90 myosin heavy chain 14 Homo sapiens 43-49 16624636-10 2006 Simultaneous inclusion of exogenous ATP and chelation of Mg2+ with EDTA significantly enhanced ADP-->ATP exchange by hRAD51. Adenosine Diphosphate 95-98 RAD51 recombinase Homo sapiens 120-126 16624636-11 2006 These studies are consistent with the hypothesis that Mg2+ influences the discrimination and release of ADP, which may sequentially impose an important regulatory step in the hRAD51 ATPase cycle. Adenosine Diphosphate 104-107 RAD51 recombinase Homo sapiens 175-181 16672234-4 2006 Steady-state and transient kinetic analysis indicate that both effects are due, at least in part, to a reduction of the affinity of GroEL for ADP. Adenosine Diphosphate 142-145 heat shock protein family D (Hsp60) member 1 Homo sapiens 132-137 21043655-6 1996 MDP-1 inhibited ADP and thrombin induced aggregation. Adenosine Diphosphate 16-19 magnesium dependent phosphatase 1 Homo sapiens 0-5 16540465-7 2006 The patterns of product inhibition of AKT1, AKT2, and AKT3 by ADP were all consistent with an ordered substrate addition mechanism with ATP binding to the enzymes prior to the peptide substrate. Adenosine Diphosphate 62-65 AKT serine/threonine kinase 3 Homo sapiens 54-58 21043655-7 1996 In addition, MDP-1 inhibited ADP induced release of ATP, but did not inhibit thrombin stimulated ATP release. Adenosine Diphosphate 29-32 magnesium dependent phosphatase 1 Homo sapiens 13-18 16585515-7 2006 The ATPase pathway is rate-limited by a reversible interconversion between two distinct ADP-bound actomyosin states, which results in high steady-state occupancy of a strongly actin-bound myosin species. Adenosine Diphosphate 88-91 spaghetti squash Drosophila melanogaster 102-108 7501026-0 1995 A 35-A movement of smooth muscle myosin on ADP release. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 33-39 7503740-8 1995 Upon addition of MgADP and Vi, a shift to higher temperature was observed for the lower major transition, evidencing that with trapped ADP and Vi the intermolecular interactions stabilized the myosin head region. Adenosine Diphosphate 17-22 myosin heavy chain 14 Homo sapiens 193-199 16343966-7 2006 This case represents the molecular analysis of the ALAD gene defects in the first case of ADP identified in North America, who is a compound heterozygote for two novel ALAD gene defects. Adenosine Diphosphate 90-93 delta-aminolevulinic acid dehydratase Cricetulus griseus 51-55 16343966-7 2006 This case represents the molecular analysis of the ALAD gene defects in the first case of ADP identified in North America, who is a compound heterozygote for two novel ALAD gene defects. Adenosine Diphosphate 90-93 delta-aminolevulinic acid dehydratase Cricetulus griseus 168-172 7503740-8 1995 Upon addition of MgADP and Vi, a shift to higher temperature was observed for the lower major transition, evidencing that with trapped ADP and Vi the intermolecular interactions stabilized the myosin head region. Adenosine Diphosphate 19-22 myosin heavy chain 14 Homo sapiens 193-199 8519760-6 1995 (2) At the high concentrations of myosin subfragment-1 used in some experiments, significant amounts of ADP may form. Adenosine Diphosphate 104-107 myosin heavy chain 14 Homo sapiens 34-40 16415346-7 2006 The rate of ADP dissociation from actomyosin VIIA was 1.86 s(-1), which was comparable with the overall ATPase cycle rate, thus assigned to be a rate-determining step. Adenosine Diphosphate 12-15 Vacuolar H[+] ATPase 14kD subunit 1 Drosophila melanogaster 104-110 16415346-8 2006 The results suggest that Drosophila myosin VIIA spends the majority of the ATPase cycle in an actomyosin.ADP form, a strong actin binding state. Adenosine Diphosphate 105-108 Vacuolar H[+] ATPase 14kD subunit 1 Drosophila melanogaster 75-81 16455491-1 2006 Crucial to the function of Hsp70 chaperones is the nucleotide-regulated transition between two conformational states, the ATP bound state with high association and dissociation rates for substrates and the ADP bound state with two and three orders of magnitude lower association and dissociation rates. Adenosine Diphosphate 206-209 heat shock protein family A (Hsp70) member 4 Homo sapiens 27-32 16405437-7 2006 Among the 34 positive plasmas, four with positive anti-GPIIb/IIIa autoantibody showed significant inhibition of platelet aggregation induced by adenosine diphosphate (ADP), whereas one with GPIb/IX-specific antibody inhibited ristocetin-induced platelet aggregation. Adenosine Diphosphate 144-165 integrin subunit alpha 2b Homo sapiens 55-60 16405437-7 2006 Among the 34 positive plasmas, four with positive anti-GPIIb/IIIa autoantibody showed significant inhibition of platelet aggregation induced by adenosine diphosphate (ADP), whereas one with GPIb/IX-specific antibody inhibited ristocetin-induced platelet aggregation. Adenosine Diphosphate 167-170 integrin subunit alpha 2b Homo sapiens 55-60 16401075-2 2006 Although UTP is the preferred phosphoryl donor for this reaction, our previous studies reported dCK structures solely containing ADP in the phosphoryl donor binding site. Adenosine Diphosphate 129-132 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 96-99 16278211-2 2006 Mammalian cells contain mono-ADP-ribosyltransferases that catalyze the formation of ADP-ribose-(arginine) protein, which can be cleaved by a 39-kDa ADP-ribose-(arginine) protein hydrolase (ARH1), resulting in release of free ADP-ribose and regeneration of unmodified protein. Adenosine Diphosphate 29-32 ADP-ribosylarginine hydrolase Homo sapiens 189-193 16278211-5 2006 We report here the identification of an ARH1-like protein, termed poly(ADP-ribose) hydrolase or ARH3, which exhibited PARG activity, generating ADP-ribose from poly-(ADP-ribose), but did not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Adenosine Diphosphate 71-74 ADP-ribosylarginine hydrolase Homo sapiens 40-44 17668698-6 2006 RESULTS: Gemfibrozil elevated significantly apolipoprotein A-I, but decreased the total cholesterol, LDL cholesterol, triglycerides, the lipid indices, the ADP-induced platelet aggregation, plasminogen, alpha2-antiplasmin and hematocrit. Adenosine Diphosphate 156-159 serpin family F member 2 Homo sapiens 203-221 16219773-2 2006 Using Drosophila genetic tools, we characterize the expression and function of poly(ADP-ribose) glycohydrolase (PARG), the primary enzyme responsible for degrading protein-bound ADP-ribose moieties. Adenosine Diphosphate 84-87 Poly(ADP-ribose) glycohydrolase Drosophila melanogaster 112-116 16219773-3 2006 Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules. Adenosine Diphosphate 143-146 Poly(ADP-ribose) glycohydrolase Drosophila melanogaster 34-38 16219773-3 2006 Strongly increasing or decreasing PARG levels mimics the effects of Parp mutation, supporting PARG"s postulated roles in vivo both in removing ADP-ribose adducts and in facilitating multiple activity cycles by individual PARP molecules. Adenosine Diphosphate 143-146 Poly(ADP-ribose) glycohydrolase Drosophila melanogaster 94-98 16685599-3 2006 TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Adenosine Diphosphate 241-244 transient receptor potential cation channel subfamily C member 4 Homo sapiens 10-15 16685599-3 2006 TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Adenosine Diphosphate 241-244 transient receptor potential cation channel subfamily M member 2 Homo sapiens 148-153 16361109-4 2006 We have calculated helically averaged 3D maps of microtubules decorated with ZEN-4 motor domain in the presence of AMP-PNP, ADP, ADP-AlF(4)(-), and nucleotide-free conditions. Adenosine Diphosphate 124-127 Kinesin-like protein Caenorhabditis elegans 77-82 15920726-5 2005 In the present study, we report that the ADP-induced chemotaxis of microglia is mediated by P2Y12/13 receptors and is beta1 integrin-dependent in the presence of fibronectin. Adenosine Diphosphate 41-44 integrin subunit beta 1 Homo sapiens 118-132 16099930-5 2005 Exposure to extracellular ATP, UTP, ADP, and UDP at concentrations ranging from 10(-6) to 10(-4) M, produced significant increases in intracellular Ca(2+) that peaked to 491 +/- 51 nM (p < 0.001) with ATP 10(-5) M and to 321 +/- 30 nM with UTP 10(-4) M. ATP and UTP also induced HASM cell contraction, decreasing cell length by 9.9 +/- 4.3 and 5.6 +/- 2.0%, respectively. Adenosine Diphosphate 36-39 HEAT repeat containing 1 Homo sapiens 243-249 16250859-2 2005 Engagement of GPIbalpha (the major ligand-binding subunit of GPIb-IX-V) by von Willebrand factor or GPVI by collagen, leads to mobilization of cytosolic Ca2+, secretion of platelet agonists such as ADP, cytoskeletal changes, and activation of the platelet integrin alphaIIbbeta3 that mediates von Willebrand factor- or fibrinogen-dependent platelet aggregation. Adenosine Diphosphate 198-201 glycoprotein Ib platelet subunit alpha Homo sapiens 14-23 16178769-10 2005 In particular, modulation of the expression of co-stimulatory molecules on the targeted APC; CD80, CD86, CD83 and B7RP-1, play important roles for the effect of the ADP-ribosylating CTA1-based adjuvants for the development of tolerance or active IgA immunity. Adenosine Diphosphate 165-168 inducible T cell costimulator ligand Homo sapiens 114-120 16113262-3 2005 ExoS ADP-ribosylation of Rac1 is cell line dependent. Adenosine Diphosphate 5-8 Rac family small GTPase 1 Homo sapiens 25-29 16113262-5 2005 Arg66 and Arg68 within the GTPase-binding region of Rac1 were identified as preferred sites of ExoS ADP-ribosylation. Adenosine Diphosphate 100-103 Rac family small GTPase 1 Homo sapiens 52-56 16155414-5 2005 hGDH2 (nerve- specific GDH) was more sensitively affected by 1 mM ADP than hGDH1 (house-keeping GDH) on the activation by alkalized extracts. Adenosine Diphosphate 66-69 glutamate dehydrogenase 2 Homo sapiens 0-5 16155414-6 2005 Studies with cassette mutagenesis at ADP-binding site showed that hGDH2 was more sensitively regulated by ADP than hGDH1 on the activation by Corydalis ternata. Adenosine Diphosphate 37-40 glutamate dehydrogenase 2 Homo sapiens 66-71 16155414-6 2005 Studies with cassette mutagenesis at ADP-binding site showed that hGDH2 was more sensitively regulated by ADP than hGDH1 on the activation by Corydalis ternata. Adenosine Diphosphate 106-109 glutamate dehydrogenase 2 Homo sapiens 66-71 15951571-7 2005 ADP soaked into crystals of the unliganded protein reveals an intermediate conformation midway between the open and closed states and demonstrates that in GRP94 the conversion between the open and closed states is driven by ligand binding. Adenosine Diphosphate 0-3 heat shock protein 90 beta family member 1 Homo sapiens 155-160 16018971-1 2005 hRad51 binding to ssDNA is significantly lowered in the presence of a nucleotide cofactor ATP/ADP/ATPgammaS. Adenosine Diphosphate 94-97 RAD51 recombinase Homo sapiens 0-6 15961399-6 2005 The ADP off-rate from acto-myosin X was 23 s(-1), which was two times larger than the V(max). Adenosine Diphosphate 4-7 myosin X Homo sapiens 27-35 16014615-6 2005 Gene transfer of ecSOD, but not ecSODDeltaHBD, reduced levels of superoxide and improved relaxation to acetylcholine and ADP in the aorta and mesenteric artery from rats with heart failure. Adenosine Diphosphate 121-124 superoxide dismutase 3 Rattus norvegicus 17-22 15895108-2 2005 Kir6.2-containing channels are closed by ATP binding to Kir6.2, and opened by MgADP binding to SUR. Adenosine Diphosphate 78-83 potassium inwardly rectifying channel subfamily J member 11 Canis lupus familiaris 0-6 15970665-0 2005 Structure of Apaf-1 in the auto-inhibited form: a critical role for ADP. Adenosine Diphosphate 68-71 Death-associated APAF1-related killer Drosophila melanogaster 13-19 15970665-3 2005 The structure of the auto-inhibited form of Apaf-1 reveals a critical role for ADP, which serves as an organizing center for four adjoining domains. Adenosine Diphosphate 79-82 Death-associated APAF1-related killer Drosophila melanogaster 44-50 16023112-1 2005 When the influence of ADP-ribosylation on the activities of the purified human glutamate dehydrogenase isozymes (hGDH1 and hGDH2) was measured in the presence of 100 microM NAD+ for 60 min, hGDH isozymes were inhibited by up to 75%. Adenosine Diphosphate 22-25 glutamate dehydrogenase 2 Homo sapiens 123-128 15852217-3 2005 Once in the extracellular fluids, they are rapidly degraded by ectonucleotidases, such as CD39, that play a key role in neutralizing the platelet aggregatory action of adenosine diphosphate (ADP), and act on two families of receptors: the ionotropic P2X receptors and the G-protein-coupled P2Y receptors. Adenosine Diphosphate 168-189 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 90-94 15852217-3 2005 Once in the extracellular fluids, they are rapidly degraded by ectonucleotidases, such as CD39, that play a key role in neutralizing the platelet aggregatory action of adenosine diphosphate (ADP), and act on two families of receptors: the ionotropic P2X receptors and the G-protein-coupled P2Y receptors. Adenosine Diphosphate 191-194 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 90-94 15786005-7 2005 GPIIb/IIIa function was evaluated with the activation-specific antibody PAC-1 after stimulation with 10 microM ADP. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 0-5 15749861-6 2005 Depletion of CD38(high) cells from wild-type splenocytes resulted in stronger ADP-ribosylation on the remaining cells. Adenosine Diphosphate 78-81 CD38 antigen Mus musculus 13-17 15749861-7 2005 Similarly, treatment of total splenocytes with the CD38 inhibitor nicotinamide 2"-deoxy-2"-fluoroarabinoside adenine dinucleotide increased the level of cell surface ADP-ribosylation. Adenosine Diphosphate 166-169 CD38 antigen Mus musculus 51-55 15770419-3 2005 The substrate binding and release cycle is driven by the switching of Hsp70 between the low-affinity ATP bound state and the high-affinity ADP bound state. Adenosine Diphosphate 139-142 heat shock protein family A (Hsp70) member 4 Homo sapiens 70-75 15823862-3 2005 We aimed to investigate the effects of clopidogrel ex vivo and another ADP-antagonist, AR-C69931MX in vitro on thrombin receptor activating peptide (TRAP)-induced platelet aggregation, procoagulant activity, microparticle formation and [Ca(2+)]i responses in patients with ACS. Adenosine Diphosphate 71-74 TRAP Homo sapiens 111-147 15823862-3 2005 We aimed to investigate the effects of clopidogrel ex vivo and another ADP-antagonist, AR-C69931MX in vitro on thrombin receptor activating peptide (TRAP)-induced platelet aggregation, procoagulant activity, microparticle formation and [Ca(2+)]i responses in patients with ACS. Adenosine Diphosphate 71-74 TRAP Homo sapiens 149-153 15709756-0 2005 The characteristics of the (alpha V371C)3(beta R337C)3 gamma double mutant subcomplex of the TF1-ATPase indicate that the catalytic site at the alpha TP-beta TP interface with bound MgADP in crystal structures of MF1 represents a catalytic site containing inhibitory MgADP. Adenosine Diphosphate 182-187 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Homo sapiens 150-157 15709756-0 2005 The characteristics of the (alpha V371C)3(beta R337C)3 gamma double mutant subcomplex of the TF1-ATPase indicate that the catalytic site at the alpha TP-beta TP interface with bound MgADP in crystal structures of MF1 represents a catalytic site containing inhibitory MgADP. Adenosine Diphosphate 267-272 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Homo sapiens 150-157 15561722-3 2005 Here we show through structure-guided mutagenesis that TRPM2 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose binding cleft in the C-terminal nudix domain. Adenosine Diphosphate 71-74 transient receptor potential cation channel subfamily M member 2 Homo sapiens 55-60 15561722-3 2005 Here we show through structure-guided mutagenesis that TRPM2 gating by ADP-ribose and both oxidative and nitrosative stresses requires an intact ADP-ribose binding cleft in the C-terminal nudix domain. Adenosine Diphosphate 145-148 transient receptor potential cation channel subfamily M member 2 Homo sapiens 55-60 15579901-1 2005 Processivity in myosin V is mediated through the mechanical strain that results when both heads bind strongly to an actin filament, and this strain regulates the timing of ADP release. Adenosine Diphosphate 172-175 myosin VA Homo sapiens 16-24 15579901-3 2005 Answering this question will require determining which of the several potential pathways myosin V takes in the process of ADP release and how actin influences the kinetics of these pathways. Adenosine Diphosphate 122-125 myosin VA Homo sapiens 89-97 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Adenosine Diphosphate 82-85 myosin VA Homo sapiens 99-107 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Adenosine Diphosphate 193-196 myosin VA Homo sapiens 99-107 15579901-4 2005 We have addressed this issue by examining how magnesium regulates the kinetics of ADP release from myosin V and actomyosin V. Our data support a model in which actin accelerates the release of ADP from myosin V by reducing the magnesium affinity of a myosin V-MgADP intermediate. Adenosine Diphosphate 260-265 myosin VA Homo sapiens 99-107 15333609-7 2005 Furthermore, as PIO2 fell more rapidly at contraction onset in CKi compared with Con, these data suggest that CK activity temporally buffers the initial ATP-to-ADP concentration ratio at the transition to an augmented energetic demand, thereby slowing the initial mitochondrial activation by mitigating the energetic control signal (i.e., ADP concentration, phosphorylation potential, etc.) Adenosine Diphosphate 160-163 casein kinase 1 gamma 2 L homeolog Xenopus laevis 63-66 15668185-7 2005 Atorvastatin therapy normalized platelet hyperfunction in the patients studied and reduced GPIIb/IIIa response to ADP (from 82.65+/-6.43% to 75.84+/-4.89%, p<0.01). Adenosine Diphosphate 114-117 integrin subunit alpha 2b Homo sapiens 91-96 15792682-9 2005 The defined peptide interferes with the formation of the GP IIb/IIIa complex by inhibiting the binding of FITC-PAC-1 onto ADP-, type I collagen-, and type III collagen-activated platelets. Adenosine Diphosphate 122-125 integrin subunit alpha 2b Homo sapiens 57-63 15214498-9 2004 BthA-I-PLA2 showed anticoagulant activity upon human plasma and inhibited phospholipid-dependent platelet aggregation induced by collagen or ADP. Adenosine Diphosphate 141-144 phospholipase A2 group IIA Homo sapiens 7-11 15044002-6 2004 Both hGDH1 and hGDH2, however, showed much slower heat inactivation processes in the presence of 1 mM ADP or 3 mM L-Leu. Adenosine Diphosphate 102-105 glutamate dehydrogenase 2 Homo sapiens 15-20 14664695-1 2004 The chaperone activity of Hsp70 (70 kDa heat-shock protein) in protein folding and its conformational switch, including oligomeric and monomeric interconversion, are regulated by the hydrolysis of ATP and the ATP-ADP exchange cycle. Adenosine Diphosphate 213-216 heat shock protein family A (Hsp70) member 4 Homo sapiens 26-31 14992598-2 2004 The kinetics of monomeric myosin V containing a single IQ domain (MV 1IQ) differ from nonprocessive myosin II in that actin affinity is higher, phosphate release is extremely rapid, and ADP release is rate-limiting. Adenosine Diphosphate 186-189 myosin VA Homo sapiens 26-34 12842985-7 2003 Furthermore, Btk-/-/Tec-/- platelets fail to undergo an increase in Ca2+, aggregation, secretion, and spreading in response to collagen or CRP, whereas they aggregate normally to adenosine diphosphate (ADP) and spread on fibrinogen. Adenosine Diphosphate 179-200 Bruton tyrosine kinase Homo sapiens 13-16 12842985-7 2003 Furthermore, Btk-/-/Tec-/- platelets fail to undergo an increase in Ca2+, aggregation, secretion, and spreading in response to collagen or CRP, whereas they aggregate normally to adenosine diphosphate (ADP) and spread on fibrinogen. Adenosine Diphosphate 202-205 Bruton tyrosine kinase Homo sapiens 13-16 12842985-8 2003 A residual GPVI signal exists in the Btk-/-/Tec-/- platelets as CRP synergizes with ADP to mediate aggregation. Adenosine Diphosphate 84-87 Bruton tyrosine kinase Homo sapiens 37-40 12736270-7 2003 In the absence of hexokinase, apparent cis folding of rhodanese and malate dehydrogenase was observed in ADP and AMPPNP. Adenosine Diphosphate 105-108 malic enzyme 1 Homo sapiens 68-88 12791252-2 2003 We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41-364, in complex with staurosporine at 2.7 A and with ADP at 3.2 A, revealing overall structural similarity with other Ser/Thr kinases. Adenosine Diphosphate 172-175 MAPK activated protein kinase 2 Homo sapiens 102-105 12742022-2 2003 The metal fluorides and vanadate, complexed with ADP, are known to mimic the gamma-phosphate group of ATP, but they differ in geometry and size; it is expected that these compounds will be useful for investigating the strikingly high specificity of GroEL for ATP that enables the induction of the allosteric transition. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 249-254 12742022-3 2003 The kinetic fluorescence measurement revealed that aluminium, beryllium, and gallium ions, when complexed with the fluoride ion and ADP, induced a biphasic fluorescence change of pyrenyl GroEL, while scandium and vanadate ions did not induce any kinetically observed change in fluorescence. Adenosine Diphosphate 132-135 heat shock protein family D (Hsp60) member 1 Homo sapiens 187-192 12742022-5 2003 The dependence of the burst-phase and the first-phase fluorescence changes on the ADP concentration indicated that the burst phase represents non-cooperative nucleotide binding to GroEL, and that the first phase represents the allosteric transition of GroEL. Adenosine Diphosphate 82-85 heat shock protein family D (Hsp60) member 1 Homo sapiens 180-185 12742022-5 2003 The dependence of the burst-phase and the first-phase fluorescence changes on the ADP concentration indicated that the burst phase represents non-cooperative nucleotide binding to GroEL, and that the first phase represents the allosteric transition of GroEL. Adenosine Diphosphate 82-85 heat shock protein family D (Hsp60) member 1 Homo sapiens 252-257 12742022-7 2003 From the kinetic allosteric model analysis, the relative free energy of the transition state in the metal fluoride-ADP-induced allosteric transition of GroEL was found to be larger than the corresponding free energy of the ATP-induced allosteric transition by more than 5.5kcal/mol. Adenosine Diphosphate 115-118 heat shock protein family D (Hsp60) member 1 Homo sapiens 152-157 12777794-5 2003 D59, 783-794] enclose chain segments of symmetry-related monomers in the GroEL-GroES-(ADP)(7) chaperonin complex. Adenosine Diphosphate 86-89 heat shock protein family D (Hsp60) member 1 Homo sapiens 73-78 12871378-7 2003 Fer-deficient platelets, from mice targeted with a kinase-inactivating mutation, disaggregated more rapidly than wild-type platelets in response to ADP. Adenosine Diphosphate 148-151 fer (fms/fps related) protein kinase Mus musculus 0-3 14577157-0 2003 [Effect of ADP and GroES on interaction of molecular chaperonin GroEL with non-native lysozyme]. Adenosine Diphosphate 11-14 heat shock protein family D (Hsp60) member 1 Homo sapiens 64-69 14577157-4 2003 The addition of ADP to the complex of GroEL with nonnative lysozyme noticeably decreases the interaction of the chaperonin with nonnative protein target resulting in some increase of the efficiency of its aggregation. Adenosine Diphosphate 16-19 heat shock protein family D (Hsp60) member 1 Homo sapiens 38-43 14577157-5 2003 However, the addition of the co-chaperonin GroES together with ADP (i.e. the formation of the complex of GroEL with GroES) leads to drastic weakness of the interaction of GroEL with nonnative lysozyme and the efficiency of its aggregation becomes comparable with that in the absence of GroEL. Adenosine Diphosphate 63-66 heat shock protein family D (Hsp60) member 1 Homo sapiens 105-110 14577157-5 2003 However, the addition of the co-chaperonin GroES together with ADP (i.e. the formation of the complex of GroEL with GroES) leads to drastic weakness of the interaction of GroEL with nonnative lysozyme and the efficiency of its aggregation becomes comparable with that in the absence of GroEL. Adenosine Diphosphate 63-66 heat shock protein family D (Hsp60) member 1 Homo sapiens 171-176 14577157-5 2003 However, the addition of the co-chaperonin GroES together with ADP (i.e. the formation of the complex of GroEL with GroES) leads to drastic weakness of the interaction of GroEL with nonnative lysozyme and the efficiency of its aggregation becomes comparable with that in the absence of GroEL. Adenosine Diphosphate 63-66 heat shock protein family D (Hsp60) member 1 Homo sapiens 171-176 12475791-0 2002 Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in beta-cells. Adenosine Diphosphate 54-57 CD38 antigen Mus musculus 42-46 12537023-1 2002 We studied the inhibition of mitochondrial malate dehydrogenase (mMDH) by the nucleotides cAMP, AMP, ADP, ATP. Adenosine Diphosphate 101-104 malic enzyme 1 Homo sapiens 43-63 12537023-1 2002 We studied the inhibition of mitochondrial malate dehydrogenase (mMDH) by the nucleotides cAMP, AMP, ADP, ATP. Adenosine Diphosphate 101-104 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 65-69 12428106-4 2002 Analysis of integrin alpha(2)beta(1)-dependent platelet adhesion to collagen indicated that ADP-induced suppression of platelet adhesion is the result of trans-dominant inhibition of integrin alpha(2)beta(1) caused by fibrinogen binding to integrin GPIIb-IIIa. Adenosine Diphosphate 92-95 integrin subunit alpha 2b Homo sapiens 249-254 12653477-13 2002 Adenosine diphosphate (ADP) also blocks Hsp70-mediated liposome aggregation. Adenosine Diphosphate 0-21 heat shock protein family A (Hsp70) member 4 Homo sapiens 40-45 12653477-13 2002 Adenosine diphosphate (ADP) also blocks Hsp70-mediated liposome aggregation. Adenosine Diphosphate 23-26 heat shock protein family A (Hsp70) member 4 Homo sapiens 40-45 12653477-14 2002 Micromolar concentrations of ADP enhance Hsc70-induced liposome aggregation, whereas at millimolar concentrations the nucleotide has an inhibitory effect. Adenosine Diphosphate 29-32 heat shock protein family A (Hsp70) member 8 Homo sapiens 41-46 12479404-8 2002 This set was supported by comparison of predictions arising from this set of values with experimental data for hydrolysis of ATP in the presence of ADP and ATPgammaS, binding of ATPgammaS and ADP to GroEL in the absence of ATP, and binding of ATP as monitored by fluorescence labelling. Adenosine Diphosphate 192-195 heat shock protein family D (Hsp60) member 1 Homo sapiens 199-204 12198249-0 2002 Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Adenosine Diphosphate 105-108 glucagon Rattus norvegicus 0-23 12145146-4 2002 Benfluorex inhibited gluconeogenesis at the level of pyruvate carboxylase (45% fall in acetyl-CoA concentration) and of glyceraldehyde-3-phosphate dehydrogenase (decrease in ATP/ADP and NAD(+)/NADH ratios). Adenosine Diphosphate 178-181 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 120-160 11839740-5 2002 Here, we examined hRAD51 binding and ATPase inhibition pattern by ADP and ATP/adenosine 5"-O-(thiotriphosphate) (ATPgammaS). Adenosine Diphosphate 66-69 RAD51 recombinase Homo sapiens 18-24 11839740-7 2002 The binding of ADP to hRAD51 appeared bimodal. Adenosine Diphosphate 15-18 RAD51 recombinase Homo sapiens 22-28 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 145-148 RAD51 recombinase Homo sapiens 207-213 11839740-8 2002 The first mode was identical to ATP/ATPgammaS binding (K(app1) approximately 3 microm; 1 ADP/1 hRAD51), while a second mode occurred at elevated ADP concentrations (K(app2) > or = 125 microm; >1 ADP/1 hRAD51). Adenosine Diphosphate 145-148 RAD51 recombinase Homo sapiens 207-213 11839740-10 2002 At low ATP concentrations (<0.3 mm), ADP and ATPgammaS competitively inhibit the hRAD51 ATPase (K(m)((app)) > K(m)). Adenosine Diphosphate 40-43 RAD51 recombinase Homo sapiens 84-90 12034470-7 2002 Flux-dependent gradients up to 23 microM ADP (for a diffusion rate of J(Dif)=1.9 micromol ADP/min/mg mitochondrial protein) were observed. Adenosine Diphosphate 41-44 seminal vesicle secretory protein 4 Rattus norvegicus 90-122 11939802-5 2002 In addition, we demonstrate that efficient folding in the chaperonin cavity requires ATP hydrolysis, as formation of ternary GroEL/GroES complexes with substrate proteins in the presence of ADP results only in very inefficient reactivation. Adenosine Diphosphate 190-193 heat shock protein family D (Hsp60) member 1 Homo sapiens 125-130 11929769-3 2002 We and others have documented that NTPDase1 (CD39, 78 kd) hydrolyzes both triphosphonucleosides and diphosphonucleosides and thereby terminates platelet aggregation responses to adenosine diphosphate (ADP). Adenosine Diphosphate 178-199 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 35-43 11929769-3 2002 We and others have documented that NTPDase1 (CD39, 78 kd) hydrolyzes both triphosphonucleosides and diphosphonucleosides and thereby terminates platelet aggregation responses to adenosine diphosphate (ADP). Adenosine Diphosphate 178-199 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 45-49 11929769-3 2002 We and others have documented that NTPDase1 (CD39, 78 kd) hydrolyzes both triphosphonucleosides and diphosphonucleosides and thereby terminates platelet aggregation responses to adenosine diphosphate (ADP). Adenosine Diphosphate 201-204 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 35-43 11929769-3 2002 We and others have documented that NTPDase1 (CD39, 78 kd) hydrolyzes both triphosphonucleosides and diphosphonucleosides and thereby terminates platelet aggregation responses to adenosine diphosphate (ADP). Adenosine Diphosphate 201-204 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 45-49 11929769-8 2002 In this context, NTPDase1 should abrogate platelet aggregation and recruitment in intact vessels by the conversion of ADP to adenosine monophosphate, while NTPDase2 expression would promote platelet microthrombus formation at sites of extravasation following vessel injury. Adenosine Diphosphate 118-121 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 17-25 11872671-5 2002 The activity of the mutant GDH (GDH266C), expressed in COS-7 cells, was constitutively elevated, and allosteric regulations by ADP and GTP were severely impaired. Adenosine Diphosphate 127-130 crystallin lambda 1 Homo sapiens 27-30 11872671-5 2002 The activity of the mutant GDH (GDH266C), expressed in COS-7 cells, was constitutively elevated, and allosteric regulations by ADP and GTP were severely impaired. Adenosine Diphosphate 127-130 crystallin lambda 1 Homo sapiens 32-39 11841236-0 2002 Rhodanese can partially refold in its GroEL-GroES-ADP complex and can be released to give a homogeneous product. Adenosine Diphosphate 50-53 heat shock protein family D (Hsp60) member 1 Homo sapiens 38-43 11841236-4 2002 Rhodanese partially folds while in the GroEL-GroES-ADP complex, but it does not significantly reach an active state. Adenosine Diphosphate 51-54 heat shock protein family D (Hsp60) member 1 Homo sapiens 39-44 11841236-5 2002 Partially folded rhodanese can be released from the GroEL-GroES-ADP complex by subdenaturing concentrations of urea as a homogeneous species that is committed to fold to the native conformation with little or no partitioning to the aggregated state. Adenosine Diphosphate 64-67 heat shock protein family D (Hsp60) member 1 Homo sapiens 52-57 11739745-13 2002 These findings establish tankyrase 2 as a bona fide PARP, with itself and TRF1 as acceptors of ADP-ribosylation, and suggest the possibility of a role for tankyrase 2 at telomeres. Adenosine Diphosphate 95-98 tankyrase 2 Homo sapiens 25-36 11585851-10 2001 This effect may be explained by a direct stimulatory interaction of NBF2/MgADP moiety with another region of Kir6.2 (perhaps the NH2 terminus), or by NBF2/MgADP still promoting a weak interaction between NBF1 and Kir6.2 in the absence of ATP. Adenosine Diphosphate 73-78 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 109-115 11585851-10 2001 This effect may be explained by a direct stimulatory interaction of NBF2/MgADP moiety with another region of Kir6.2 (perhaps the NH2 terminus), or by NBF2/MgADP still promoting a weak interaction between NBF1 and Kir6.2 in the absence of ATP. Adenosine Diphosphate 73-78 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 213-219 11585851-10 2001 This effect may be explained by a direct stimulatory interaction of NBF2/MgADP moiety with another region of Kir6.2 (perhaps the NH2 terminus), or by NBF2/MgADP still promoting a weak interaction between NBF1 and Kir6.2 in the absence of ATP. Adenosine Diphosphate 155-160 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 213-219 11563916-0 2001 Nucleotide-induced transition of GroEL from the high-affinity to the low-affinity state for a target protein: effects of ATP and ADP on the GroEL-affected refolding of alpha-lactalbumin. Adenosine Diphosphate 129-132 heat shock protein family D (Hsp60) member 1 Homo sapiens 33-38 11563916-0 2001 Nucleotide-induced transition of GroEL from the high-affinity to the low-affinity state for a target protein: effects of ATP and ADP on the GroEL-affected refolding of alpha-lactalbumin. Adenosine Diphosphate 129-132 heat shock protein family D (Hsp60) member 1 Homo sapiens 140-145 11563916-7 2001 The results show that the observed difference between ATP and ADP-induced transitions of GroEL are brought about by a small difference in an allosteric parameter (the ratio of the nucleotide affinities of GroEL in the high-affinity and the low-affinity states), i.e. 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 62-65 heat shock protein family D (Hsp60) member 1 Homo sapiens 89-94 11563916-7 2001 The results show that the observed difference between ATP and ADP-induced transitions of GroEL are brought about by a small difference in an allosteric parameter (the ratio of the nucleotide affinities of GroEL in the high-affinity and the low-affinity states), i.e. 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 62-65 heat shock protein family D (Hsp60) member 1 Homo sapiens 205-210 11563916-7 2001 The results show that the observed difference between ATP and ADP-induced transitions of GroEL are brought about by a small difference in an allosteric parameter (the ratio of the nucleotide affinities of GroEL in the high-affinity and the low-affinity states), i.e. 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 291-294 heat shock protein family D (Hsp60) member 1 Homo sapiens 89-94 11563916-7 2001 The results show that the observed difference between ATP and ADP-induced transitions of GroEL are brought about by a small difference in an allosteric parameter (the ratio of the nucleotide affinities of GroEL in the high-affinity and the low-affinity states), i.e. 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 291-294 heat shock protein family D (Hsp60) member 1 Homo sapiens 205-210 11500375-4 2001 In vitro binding assays showed that the association of FANCC and Hsp70 involves the ATPase domain of Hsp70 and the central 320 residues of FANCC, and that both Hsp40 and ATP/ADP are required. Adenosine Diphosphate 174-177 heat shock protein family A (Hsp70) member 4 Homo sapiens 65-70 11384977-1 2001 The low-level expression of the bovine heart mitochondrial ADP/ATP carrier (bovine type 1 ADP/ATP carrier (bAAC1)) in the yeast mitochondrial membrane is significantly improved by replacement of its N-terminal region with corresponding regions of the yeast type 1 and 2 carriers (yAAC1 and yAAC2) (Hashimoto, M., Shinohara, Y., Majima, E., Hatanaka, T., Yamazaki, N., and Terada, H. (1999) Biochim. Adenosine Diphosphate 59-62 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 280-285 11384977-1 2001 The low-level expression of the bovine heart mitochondrial ADP/ATP carrier (bovine type 1 ADP/ATP carrier (bAAC1)) in the yeast mitochondrial membrane is significantly improved by replacement of its N-terminal region with corresponding regions of the yeast type 1 and 2 carriers (yAAC1 and yAAC2) (Hashimoto, M., Shinohara, Y., Majima, E., Hatanaka, T., Yamazaki, N., and Terada, H. (1999) Biochim. Adenosine Diphosphate 90-93 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 280-285 11385575-0 2001 ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Adenosine Diphosphate 0-3 transient receptor potential cation channel subfamily M member 2 Homo sapiens 43-49 11342419-5 2001 These variations generally reflect the phenotype of ALAD in vivo in patients with ADP and indicate that GST-ALAD fusion protein is indeed useful for predicting of the phenotype of ALAD mutants. Adenosine Diphosphate 82-85 aminolevulinate dehydratase Homo sapiens 52-56 11342419-5 2001 These variations generally reflect the phenotype of ALAD in vivo in patients with ADP and indicate that GST-ALAD fusion protein is indeed useful for predicting of the phenotype of ALAD mutants. Adenosine Diphosphate 82-85 aminolevulinate dehydratase Homo sapiens 108-112 11342419-5 2001 These variations generally reflect the phenotype of ALAD in vivo in patients with ADP and indicate that GST-ALAD fusion protein is indeed useful for predicting of the phenotype of ALAD mutants. Adenosine Diphosphate 82-85 aminolevulinate dehydratase Homo sapiens 108-112 11259526-6 2001 The (m)P2Y(4) receptor was potently, but not selectively, activated by UTP (UTP > or = ATP >ITP > GTP > CTP), and it was not activated by UDP or ADP. Adenosine Diphosphate 157-160 pyrimidinergic receptor P2Y, G-protein coupled, 4 Mus musculus 7-22 11258911-0 2001 Structural changes of mitochondrial creatine kinase upon binding of ADP, ATP, or Pi, observed by reaction-induced infrared difference spectra. Adenosine Diphosphate 68-71 creatine kinase S-type, mitochondrial Oryctolagus cuniculus 22-51 11171965-9 2001 In UCP2 as in UCP1, ATP is a stronger inhibitor than ADP, but in UCP3 ADP inhibits more strongly than ATP. Adenosine Diphosphate 70-73 uncoupling protein 3 Homo sapiens 65-69 11342042-0 2001 Nucleotide binding to the chaperonin GroEL: non-cooperative binding of ATP analogs and ADP, and cooperative effect of ATP. Adenosine Diphosphate 87-90 heat shock protein family D (Hsp60) member 1 Homo sapiens 37-42 11104700-0 2000 A carbon-source-responsive element is required for regulation of the hypoxic ADP/ATP carrier (AAC3) isoform in Saccharomyces cerevisiae. Adenosine Diphosphate 77-80 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 94-98 10931828-8 2000 The association of ABC50 with ribosomal subunits was increased by ATP and decreased by ADP. Adenosine Diphosphate 87-90 ATP binding cassette subfamily F member 1 Homo sapiens 19-24 11001901-4 2000 Clot retraction inhibition by D3 was not due to altered platelet-fibrin interaction; however, combination treatments of D3 and adenosine diphosphate (ADP) inhibited full-scale aggregation and decreased the amounts of GPIIb-IIIa and talin incorporated into the core cytoskeletons. Adenosine Diphosphate 127-148 integrin subunit alpha 2b Homo sapiens 217-222 11001901-4 2000 Clot retraction inhibition by D3 was not due to altered platelet-fibrin interaction; however, combination treatments of D3 and adenosine diphosphate (ADP) inhibited full-scale aggregation and decreased the amounts of GPIIb-IIIa and talin incorporated into the core cytoskeletons. Adenosine Diphosphate 150-153 integrin subunit alpha 2b Homo sapiens 217-222 10960365-2 2000 A consequence of oxidative damage is the accumulation of DNA strand breaks and activation of poly(ADP-ribose) polymerase (PARP), which subsequently catalyzes ADP-ribosylation of target proteins. Adenosine Diphosphate 98-101 poly (ADP-ribose) polymerase family, member 1 Mus musculus 122-126 10944217-4 2000 These data show that myosin-V is a tightly coupled motor whose cycle time is limited by ADP release. Adenosine Diphosphate 88-91 myosin VA Homo sapiens 21-29 10816561-9 2000 In [(3)H]NECA displacement assays, GRP94 displayed binding interactions with ATP, dATP, ADP, AMP, cAMP, and adenosine, but not GTP, CTP, or UTP. Adenosine Diphosphate 88-91 heat shock protein 90 beta family member 1 Homo sapiens 35-40 10816561-11 2000 A hypothesis on the regulation of GRP94 conformation and activity by adenosine-based ligand(s) other than ATP and ADP is presented. Adenosine Diphosphate 114-117 heat shock protein 90 beta family member 1 Homo sapiens 34-39 10809723-8 2000 Both isoforms stimulated ATP hydrolysis by Hsc70 in an Hsp40-dependent manner through an acceleration of ADP-ATP exchange. Adenosine Diphosphate 105-108 heat shock protein family A (Hsp70) member 8 Homo sapiens 43-48 10841343-2 2000 PARG is the key enzyme degrading ADP-ribose polymers produced by PARP. Adenosine Diphosphate 33-36 poly (ADP-ribose) glycohydrolase Mus musculus 0-4 10841343-2 2000 PARG is the key enzyme degrading ADP-ribose polymers produced by PARP. Adenosine Diphosphate 33-36 poly (ADP-ribose) polymerase family, member 1 Mus musculus 65-69 10820018-8 2000 Surprisingly, PAR4 activation is much more effective than PAR1 activation in mounting secondary autocrine Ca(2+) signals from secreted ADP. Adenosine Diphosphate 135-138 F2R like thrombin or trypsin receptor 3 Homo sapiens 14-18 10820018-9 2000 The strong ADP response due to activated PAR4, however, requires prior activation of PAR1 as would normally occur during treatment of platelets with thrombin. Adenosine Diphosphate 11-14 F2R like thrombin or trypsin receptor 3 Homo sapiens 41-45 10760524-0 2000 The cytotoxic action of Bax on yeast cells does not require mitochondrial ADP/ATP carrier but may be related to its import to the mitochondria. Adenosine Diphosphate 74-77 BCL2-associated X protein Mus musculus 24-27 10735780-4 2000 Unfractionated heparin increased adenosine diphosphate-induced expression of P-selectin and GP IIb-IIIa in a dose-dependent manner. Adenosine Diphosphate 33-54 integrin subunit alpha 2b Homo sapiens 92-98 10704169-6 2000 Surface expression of GP IIb/IIIa was similar in resting platelets of all 3 genotypes but was significantly greater on Pl(A2,A2) platelets after ADP stimulation (P=0.003 versus Pl(A1,A1); P=0.03 versus Pl(A1,A2)). Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 22-28 10704169-6 2000 Surface expression of GP IIb/IIIa was similar in resting platelets of all 3 genotypes but was significantly greater on Pl(A2,A2) platelets after ADP stimulation (P=0.003 versus Pl(A1,A1); P=0.03 versus Pl(A1,A2)). Adenosine Diphosphate 145-148 phospholipase A2 group IIA Homo sapiens 119-124 10648841-3 2000 ADP and collagen, which as well as thrombin stimulated release of ATP from platelets, also enhanced the release of Gas6, suggesting that the mechanism of its release was similar to that of ATP release. Adenosine Diphosphate 0-3 growth arrest specific 6 Rattus norvegicus 115-119 10592661-3 2000 The elucidation of the atomic structure of the HCV NS3 helicase in complex with oligonucleotide and with ADP has helped clarify our understanding of potential sites for inhibitor binding. Adenosine Diphosphate 105-108 KRAS proto-oncogene, GTPase Homo sapiens 51-54 11467409-1 2000 Hypothesizing that UCP2 may influence insulin secretion by modifying the ATP/ADP ratio within pancreatic islets, we have investigated the expression of intraislet UCP2 gene in rats showing insulin oversecretion (non-diabetic Zucker fa/fa obese rats, glucose-infused Wistar rats) or insulin undersecretion (fasting and mildly diabetic rats). Adenosine Diphosphate 77-80 uncoupling protein 2 Rattus norvegicus 19-23 10601323-2 1999 The activity of the K(ATP) channel, composed of SUR1 and Kir6.2 subunits, is regulated by intracellular ATP and ADP, but the molecular mechanism is not clear. Adenosine Diphosphate 112-115 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 57-63 10519645-6 1999 The purified PLA2 inhibited ADP, collagen and epinephrine induced human platelet aggregation and the inhibition was both dose and time dependent. Adenosine Diphosphate 28-31 phospholipase A2 group IIA Homo sapiens 13-17 10551820-4 1999 For both IKKalpha and IKKbeta, the product ADP was a competitive inhibitor versus ATP and a non-competitive inhibitor versus IkappaBalpha. Adenosine Diphosphate 43-46 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 9-17 10512721-7 1999 When GroES was present, ATP as well as ADP and AMP-PNP were effective in reducing the affinity between GroEL and the refolding intermediate of alpha-lactalbumin. Adenosine Diphosphate 39-42 heat shock protein family D (Hsp60) member 1 Homo sapiens 103-108 10512721-8 1999 The affinity at a saturating concentration of ADP or AMP-PNP was about ten times lower than with GroEL alone. Adenosine Diphosphate 46-49 heat shock protein family D (Hsp60) member 1 Homo sapiens 97-102 10512721-9 1999 The ADP concentration at which the acceleration of the GroEL/ES-affected refolding of alphaLA was observed, was higher than the concentration at which the nucleotide-induced formation of the GroEL/ES complex took place. Adenosine Diphosphate 4-7 heat shock protein family D (Hsp60) member 1 Homo sapiens 55-60 10512721-9 1999 The ADP concentration at which the acceleration of the GroEL/ES-affected refolding of alphaLA was observed, was higher than the concentration at which the nucleotide-induced formation of the GroEL/ES complex took place. Adenosine Diphosphate 4-7 heat shock protein family D (Hsp60) member 1 Homo sapiens 191-196 10500152-10 1999 The response mediated by PAR4, however, was limited to platelet aggregation and similar to that triggered in platelets by weaker agonists such as ADP or epinephrine. Adenosine Diphosphate 146-149 F2R like thrombin or trypsin receptor 3 Homo sapiens 25-29 10471503-2 1999 DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends. Adenosine Diphosphate 90-93 poly (ADP-ribose) polymerase family, member 1 Mus musculus 15-19 10471503-2 1999 DNA binding by PARP triggers primarily its own modification by the sequential addition of ADP-ribose units to form polymers; this modification, in turn, causes the release of PARP from DNA ends. Adenosine Diphosphate 90-93 poly (ADP-ribose) polymerase family, member 1 Mus musculus 175-179 7593235-8 1995 Adenosine diphosphate, a potent stimulator of cell migration which enhances expression of u-PA and PAI-1 in nonwounded cultures, additively stimulates these genes after wounding and may thereby potentiate wound healing. Adenosine Diphosphate 0-21 serpin family E member 1 Homo sapiens 99-104 10553581-4 1999 ATP binding is followed by two parallel paths, which occur at each of the two half sites for phosphorylation-dephosphorylation, and direct ATP hydrolysis via (NaE1P : E.ATP)2, (E2P : E.ATP : E2P : E.ADP/Pi) and (KE2 : E.ADP/Pi)2, respectively. Adenosine Diphosphate 199-202 prefoldin subunit 6 Homo sapiens 212-215 10553581-4 1999 ATP binding is followed by two parallel paths, which occur at each of the two half sites for phosphorylation-dephosphorylation, and direct ATP hydrolysis via (NaE1P : E.ATP)2, (E2P : E.ATP : E2P : E.ADP/Pi) and (KE2 : E.ADP/Pi)2, respectively. Adenosine Diphosphate 220-223 prefoldin subunit 6 Homo sapiens 212-215 10553581-5 1999 The sequential formation of E2P from NaE1P and KE2 from E2P is accompanied by, respectively, hydrolysis of half of the TCA-labile bound ATP to ADP/Pi and of another half of the bound ATP to ADP/Pi. Adenosine Diphosphate 143-146 prefoldin subunit 6 Homo sapiens 47-50 7490513-0 1995 An aldose reductase inhibitor, TAT, reduces ADP-induced platelet hyperaggregation in streptozotocin-induced diabetic rats with neuropathy. Adenosine Diphosphate 44-47 tyrosine aminotransferase Rattus norvegicus 31-34 10553581-5 1999 The sequential formation of E2P from NaE1P and KE2 from E2P is accompanied by, respectively, hydrolysis of half of the TCA-labile bound ATP to ADP/Pi and of another half of the bound ATP to ADP/Pi. Adenosine Diphosphate 190-193 prefoldin subunit 6 Homo sapiens 47-50 8750228-0 1995 Effects of adenosine diphosphate on the structure of myosin cross-bridges: an X-ray diffraction study on a single skinned frog muscle fibre. Adenosine Diphosphate 11-32 myosin heavy chain 14 Homo sapiens 53-59 10393330-0 1999 AP-2 enhances Sp1-dependent activation of the growth-regulated human ATP/ADP translocator. Adenosine Diphosphate 73-76 transcription factor AP-2 alpha Homo sapiens 0-4 8750228-3 1995 Addition of 1 mM ADP to a rigor fibre increased the intensity of the third-order meridional reflection of the myosin repeat by 50-85%. Adenosine Diphosphate 17-20 myosin heavy chain 14 Homo sapiens 110-116 10369661-3 1999 Here we report the crystal structure of human GS (hGS) at 2.1 A resolution in complex with ADP, two magnesium ions, a sulfate ion and glutathione. Adenosine Diphosphate 91-94 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 46-48 8750228-7 1995 These results suggest that, upon ADP binding, the conformation of a myosin head changes without detaching from actin. Adenosine Diphosphate 33-36 myosin heavy chain 14 Homo sapiens 68-74 10369661-3 1999 Here we report the crystal structure of human GS (hGS) at 2.1 A resolution in complex with ADP, two magnesium ions, a sulfate ion and glutathione. Adenosine Diphosphate 91-94 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 50-53 8750228-8 1995 The structural change may involve a relative motion between domains of the myosin head by the closure of the cleft to which an ADP molecule binds. Adenosine Diphosphate 127-130 myosin heavy chain 14 Homo sapiens 75-81 8648299-4 1995 As bound ADP is released, a fraction of the myosin active sites bind mant-ATP and fluorescence emission rises exponentially, defining a rate of nucleotide turnover of 0.03 +/- 0.001 s-1 at 25 degrees C (n = 17). Adenosine Diphosphate 9-12 myosin heavy chain 14 Homo sapiens 44-50 10331406-8 1999 We conclude that UCP-2 has uncoupling function when overexpressed in leptin-insensitive islets and that its overexpression corrects the underexpression of the insulin gene and ameliorates glucose-stimulated insulin secretion, possibly by increasing the ATP:ADP ratio. Adenosine Diphosphate 257-260 uncoupling protein 2 Rattus norvegicus 17-22 10231370-7 1999 Hydrolysis of ATP by ecto-ATPase leads to the accumulation in the medium of extracellular ADP as an intermediate product, whereas ecto-apyrase dephosphorylates ATP directly to AMP. Adenosine Diphosphate 90-93 CEA cell adhesion molecule 1 Rattus norvegicus 21-32 7574699-7 1995 Between 1 x 10(5) and 4 x 10(5) dynes/cm2, the behavior of myosin subfragment 1 was different in the presence and in the absence of MgADP. Adenosine Diphosphate 132-137 myosin heavy chain 14 Homo sapiens 59-65 10206972-6 1999 These slowly exchanging nucleotide binding sites of rho are capable of hydrolyzing ATP, but the resulting products (ADP and Pi) bind tightly and dissociate from rho about 1500 times slower than the fast ATPase turnover. Adenosine Diphosphate 116-119 ATPase Escherichia coli 203-209 7574699-8 1995 In particular, at 1.8 x 10(5) dynes/cm2, the protein osmotic pressure in frog muscle, myosin subfragment 1 behaved as a sphere of 3.21-nm radius in the presence of MgADP and as a cylinder with a length to diameter ratio of 2.07 in the absence of MgADP. Adenosine Diphosphate 164-169 myosin heavy chain 14 Homo sapiens 86-92 10195947-9 1999 The presence of 1 or 2 PlA2 alleles was associated with increased platelet aggregability as indicated by incrementally lower threshold concentrations for epinephrine and ADP. Adenosine Diphosphate 170-173 phospholipase A2 group IIA Homo sapiens 23-27 7574699-8 1995 In particular, at 1.8 x 10(5) dynes/cm2, the protein osmotic pressure in frog muscle, myosin subfragment 1 behaved as a sphere of 3.21-nm radius in the presence of MgADP and as a cylinder with a length to diameter ratio of 2.07 in the absence of MgADP. Adenosine Diphosphate 246-251 myosin heavy chain 14 Homo sapiens 86-92 7642602-1 1995 Evidence is presented that MgADP can be noncovalently trapped in myosin subfragment 1 in the presence of ScFx resulting in the concomitant loss of ATPase function. Adenosine Diphosphate 27-32 myosin heavy chain 14 Homo sapiens 65-71 10066761-1 1999 Escherichia coli F1-ATPase from mutant betaY331W was potently inhibited by fluoroaluminate plus MgADP but not by MgADP alone. Adenosine Diphosphate 96-101 ATPase Escherichia coli 20-26 10066761-1 1999 Escherichia coli F1-ATPase from mutant betaY331W was potently inhibited by fluoroaluminate plus MgADP but not by MgADP alone. Adenosine Diphosphate 113-118 ATPase Escherichia coli 20-26 7768948-8 1995 Moreover, treatment of purified cell membranes with rTIMP-2 suppresses cholera toxin-mediated ADP-ribosylation of the GTP-binding protein, Gs alpha subunit. Adenosine Diphosphate 94-97 TIMP metallopeptidase inhibitor 2 Rattus norvegicus 52-59 10026164-7 1999 Our results suggest that the secondary structure as well as salt bridges of GroEL are modified during ATP hydrolysis, as compared with the ATP and ADP bound protein states. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 76-81 10554171-11 1999 A cocktail of blocking MAbs to CD62P, CD15, GPIIb/IIIa and the CD11b/CD18 complex had no effect on unstimulated samples, whilst totally inhibiting aggregation induced by 10(-5) M ADP, suggesting that the PLAs in unstimulated blood were preformed in vivo. Adenosine Diphosphate 179-182 integrin subunit alpha M Homo sapiens 63-68 7758459-0 1995 Expression of the AAC2 gene encoding the major mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is controlled at the transcriptional level by oxygen, heme and HAP2 factor. Adenosine Diphosphate 61-64 transcription activator HAP2 Saccharomyces cerevisiae S288C 168-172 9867869-4 1999 Suppression of translation relative to ER protein processing (cycloheximide) produced approximately 50% ADP-ribosylation of GRP78 within 90 min without eIF-2 phosphorylation. Adenosine Diphosphate 104-107 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 124-129 9867869-8 1999 Prolonged (24 h) incubations with cycloheximide resulted in the selective loss of the ADP-ribosylated form of GRP78 and increased sensitivity of eIF-2 phosphorylation in response to ER stressors. Adenosine Diphosphate 86-89 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 110-115 7787788-0 1995 [The effect of methylating lysine residues on properties of complexes of myosin subfragment-1 with ADP and phosphate analogs]. Adenosine Diphosphate 99-102 myosin heavy chain 14 Homo sapiens 73-79 9867869-9 1999 Brefeldin A decreased ADP-ribosylation of GRP78 in parallel with increased eIF-2 phosphorylation. Adenosine Diphosphate 22-25 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 42-47 7890675-5 1995 In contrast, productive binding of the ADP/ATP carrier was not inhibited by salt, the presequence peptide, or a deletion of Mas20p, but was strongly dependent on Mas37p/Mas70p. Adenosine Diphosphate 39-42 SAM complex subunit SAM37 Saccharomyces cerevisiae S288C 162-168 7890675-5 1995 In contrast, productive binding of the ADP/ATP carrier was not inhibited by salt, the presequence peptide, or a deletion of Mas20p, but was strongly dependent on Mas37p/Mas70p. Adenosine Diphosphate 39-42 protein channel TOM70 Saccharomyces cerevisiae S288C 169-175 7629029-1 1995 Using a technique to obtain a detailed X-ray diffraction pattern from a single frog skinned muscle fiber with synchrotron radiation and an imaging plate, we studied the arrangement of myosin heads to which ADP and vanadate are bound. Adenosine Diphosphate 206-209 myosin heavy chain 14 Homo sapiens 184-190 7629029-2 1995 The presence of 1 mM vanadate during contraction caused trapping of ADP and vanadate on the myosin head. Adenosine Diphosphate 68-71 myosin heavy chain 14 Homo sapiens 92-98 7827041-3 1995 We have studied its equilibrium and transient kinetics in the direction of 1,3-bisphosphoglycerate (1,3-bis-P-glycerate) production: ATP + 3-P-glycerate<==>ADP + 1,3-bis-P-glycerate. Adenosine Diphosphate 162-165 F1F0 ATP synthase subunit gamma Saccharomyces cerevisiae S288C 133-140 8822152-2 1995 Indeed, the cell-surface receptor-specific intoxication of neoplastic cells through the catalytic ADP-ribosylation of EF-2 is the prototype of a new class of biological response modifiers that may be generally applicable. Adenosine Diphosphate 98-101 eukaryotic translation elongation factor 2 Homo sapiens 118-122 7775389-5 1995 The terminal cell differentiation attendant upon the cell growth arrest was, but the early induction of CD38 NADase activity was not, inhibited by prior treatment of HL-60 cells with pertussis toxin, which catalyzed ADP-ribosylation of the membrane-bound alpha beta gamma-trimeric GTP-binding proteins. Adenosine Diphosphate 216-219 CD38 molecule Homo sapiens 104-108 7947841-0 1994 Myosin catalytic domain flexibility in MgADP. Adenosine Diphosphate 39-44 myosin heavy chain 14 Homo sapiens 0-6 7947841-1 1994 Conventional EPR studies of muscle fibers labeled with a novel alpha-iodoketo spin label at Cys-707 of the myosin head revealed substantial internal domain reorganization on the addition of ADP to rigor fibers. Adenosine Diphosphate 190-193 myosin heavy chain 14 Homo sapiens 107-113 7947841-9 1994 Our results imply that the myosin head in a single chemical state (AM.ADP) is capable of attaining many internal configurations, some of which are dynamic. Adenosine Diphosphate 70-73 myosin heavy chain 14 Homo sapiens 27-33 7858143-2 1994 We have previously reported that maximal platelet activation with adenosine diphosphate (100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry. Adenosine Diphosphate 66-87 ADCYAP receptor type I Homo sapiens 219-223 7858143-2 1994 We have previously reported that maximal platelet activation with adenosine diphosphate (100 microM ADP) causes rapid expression of all GPIIb-IIIa receptors for fibrinogen (FgR) (< 1-3 s), measured with FITC-labeled PAC1 by flow cytometry. Adenosine Diphosphate 100-103 ADCYAP receptor type I Homo sapiens 219-223 7858143-8 1994 On-rates and maximal extents of binding for either PAC1 or 9F9 probes showed identical [ADP]-response profiles ("KD" approximately 1.4 +/- 0.1 microM). Adenosine Diphosphate 88-91 ADCYAP receptor type I Homo sapiens 51-55 7918498-1 1994 The conformation of the active ATPase site of myosin subfragment 1 (S1) and actomyosin in myofibrils was probed by measuring the solvent accessibility of the bound ethenonucleotides epsilon ADP and epsilon ATP (during steady-state hydrolysis). Adenosine Diphosphate 190-193 myosin heavy chain 14 Homo sapiens 46-52 7918498-4 1994 In agreement with previous investigations, both epsilon ATP and epsilon ADP were almost completely protected from the quencher when bound to the active site of myosin. Adenosine Diphosphate 72-75 myosin heavy chain 14 Homo sapiens 160-166 7918498-11 1994 Thus nucleotides in the myosin pocket do not become more accessible to the solvent when myosin binds to actin in either rigor-ADP or active complexes. Adenosine Diphosphate 125-129 myosin heavy chain 14 Homo sapiens 24-30 8139548-2 1994 Insulin-induced membrane ruffling was inhibited by microinjection of rho GDI, an inhibitory GDP/GTP exchange regulator for both rho p21 and rac p21 small GTP-binding proteins, but not inhibited by microinjection of botulinum exoenzyme C3, known to selectively ADP-ribosylate rho p21 and to impair its function. Adenosine Diphosphate 260-263 Rho GDP dissociation inhibitor alpha Homo sapiens 69-76 8132533-9 1994 We propose that GMPS-BDB (or AMPS-BDB), which may exist in enolized form in aqueous solution, functions as a reactive analogue of phosphoenolpyruvate and GDP (ADP) to target Cys151 in the active site of pyruvate kinase. Adenosine Diphosphate 159-162 pyruvate kinase PKLR Oryctolagus cuniculus 203-218 9480132-4 1994 In contrast, when stored platelets are stimulated with ADP, GMP 140, expression is reduced indicating a diminished release reaction. Adenosine Diphosphate 55-58 selectin P Homo sapiens 60-67 7515044-5 1994 There was a positive correlation with in vitro P-selectin expression in response to ADP in the pre-apheresis sample and the number of platelet microparticles detected in the donor following plasmapheresis. Adenosine Diphosphate 84-87 selectin P Homo sapiens 47-57 9860959-3 1998 This GroEL-mediated rate was increased 17-fold by saturating concentrations of ATP, 11-fold by ADP and GroES, and 465-fold by ATP and GroES. Adenosine Diphosphate 95-98 heat shock protein family D (Hsp60) member 1 Homo sapiens 5-10 9771898-9 1998 It is concluded that in heart muscle mitochondria the ATP/ADP antiporter is responsible for the "mild uncoupling" under normal conditions and for major portion of the thermoregulatory uncoupling in the cold whereas the rest of thermoregulatory uncoupling is served by UCP (presumably by UCP2 since the UCP2 mRNA level is shown to strongly increase in rat heart muscle under the cold exposure conditions used). Adenosine Diphosphate 58-61 uncoupling protein 2 Rattus norvegicus 287-291 9771898-9 1998 It is concluded that in heart muscle mitochondria the ATP/ADP antiporter is responsible for the "mild uncoupling" under normal conditions and for major portion of the thermoregulatory uncoupling in the cold whereas the rest of thermoregulatory uncoupling is served by UCP (presumably by UCP2 since the UCP2 mRNA level is shown to strongly increase in rat heart muscle under the cold exposure conditions used). Adenosine Diphosphate 58-61 uncoupling protein 2 Rattus norvegicus 302-306 9759628-10 1998 For the patient, minimal aggregation and little or no phosphorylation of proteins of 80-85 kDa (cortactin), 100-105 kDa and 125-130 kDa were seen in response to ADP. Adenosine Diphosphate 161-164 cortactin Homo sapiens 96-105 9671967-5 1998 In myelinating Schwann cells of human and rat nerves, the ATP-induced rise of [Ca2+]i resulted from the activation of a P2Y2 purinoceptor subtype (rank order of potency: UTP > or = ATP >> 2-MeSATP = ADP). Adenosine Diphosphate 208-211 purinergic receptor P2Y2 Rattus norvegicus 120-124 9618560-4 1998 The beta cell KATP channel is a complex of four Kir6.2 pore-forming subunits and four SUR1 regulatory subunits: Kir6.2 mediates channel inhibition by ATP, whereas the potentiatory action of MgADP involves the nucleotide-binding domains (NBDs) of SUR1. Adenosine Diphosphate 190-195 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 48-54 7515044-6 1994 In addition, the percent expression of P-selectin and activated GpIIb/IIIa in response to ADP was reproducible in each individual studied on five separate occasions (CV < or = 8%). Adenosine Diphosphate 90-93 selectin P Homo sapiens 39-49 8165598-0 1993 Adenosine diphosphate stimulates the endothelial release of tissue-type plasminogen activator but not von Willebrand factor from isolated-perfused rat hind limbs. Adenosine Diphosphate 0-21 plasminogen activator, tissue type Rattus norvegicus 60-93 8165598-6 1993 Rather, ADP is capable of causing the acute release of t-PA without the simultaneous release of vWF in the ex vivo rat hindquarter model. Adenosine Diphosphate 8-11 plasminogen activator, tissue type Rattus norvegicus 55-59 8165598-7 1993 This indicates that the bradykinin- and ADP-induced pathways for t-PA release are probably distinct and that the releases of t-PA and vWF are not as closely linked as previously believed. Adenosine Diphosphate 40-43 plasminogen activator, tissue type Rattus norvegicus 65-69 8241105-4 1993 This dose of c7E3-Fab blocked 96 +/- 1% of the platelet GPIIb/IIIa receptors and abolished ADP-induced platelet aggregation. Adenosine Diphosphate 91-94 FA complementation group B Homo sapiens 18-21 8215437-3 1993 This requirement for ATP could be replaced by malate plus ADP; under these conditions this cytosol-located decarboxylation of oxaloacetate via PEP carboxykinase was sustained by respiratory ATP. Adenosine Diphosphate 58-61 phosphoenolpyruvate carboxykinase 1 Homo sapiens 143-160 8400294-10 1993 Aspirin and an adenosine diphosphate scavenger system had only a slight but not significant effect on changes in antibody binding induced by cathepsin G. Adenosine Diphosphate 15-36 cathepsin G Homo sapiens 141-152 8405450-0 1993 Calorimetric characterization of the stable complex of myosin subfragment 1 with ADP and beryllium fluoride. Adenosine Diphosphate 81-84 myosin heavy chain 14 Homo sapiens 55-61 8405450-1 1993 The thermal unfolding of the myosin subfragment 1 (S1) in its stable complex with ADP and beryllium fluoride (S1.ADP.BeF3-) was studied by differential scanning calorimetry. Adenosine Diphosphate 82-85 myosin heavy chain 14 Homo sapiens 29-35 8405450-3 1993 It is concluded that the S1.ADP.BeF3- complex can be considered, like the S1.ADP.Vi complex, a stable structural analogue of the myosin head.ADP.Pi transition state of the myosin-catalyzed ATP hydrolysis. Adenosine Diphosphate 28-31 myosin heavy chain 14 Homo sapiens 129-135 8405450-3 1993 It is concluded that the S1.ADP.BeF3- complex can be considered, like the S1.ADP.Vi complex, a stable structural analogue of the myosin head.ADP.Pi transition state of the myosin-catalyzed ATP hydrolysis. Adenosine Diphosphate 28-31 myosin heavy chain 14 Homo sapiens 172-178 7687162-4 1993 To further explore the mechanisms responsible for platelet alpha-granule secretion, we have shown that inhibition of Na+/H+ exchange by either acidification of the extracellular medium or amiloride treatment blocked ADP-induced P-selectin expression. Adenosine Diphosphate 216-219 selectin P Homo sapiens 228-238 8390984-0 1993 Selective binding of gelsolin to actin monomers containing ADP. Adenosine Diphosphate 59-62 gelsolin Homo sapiens 21-29 8390984-2 1993 In the presence of Ca2+ but not Mg2+, gelsolin retains the ability to sever actin filaments when incubated for more than 20 min with an excess of G-actin in the presence of ATP but loses severing activity within seconds when mixed with G-actin in ADP. Adenosine Diphosphate 247-250 gelsolin Homo sapiens 38-46 8390984-3 1993 Immunoprecipitation of gelsolin removes more actin from ADP than from ATP solutions. Adenosine Diphosphate 56-59 gelsolin Homo sapiens 23-31 8390984-5 1993 Coincident with the slow complex formation in MgCl2, the actin bound to the calcium-sensitive actin binding domain of gelsolin hydrolyzes its ATP to ADP. Adenosine Diphosphate 149-152 gelsolin Homo sapiens 118-126 7684475-2 1993 A granule membrane protein, granulophysin, has recently been identified in the membranes of platelet dense granules, organelles that contain stored ADP, ATP, serotonin, and calcium. Adenosine Diphosphate 148-151 CD63 molecule Homo sapiens 28-41 9693739-7 1998 Consequently, the relative increase of respiratory flux by ADP activation, expressed as the adenylate control ratio, declined under hypoxia, but not to the extreme of a complete loss of the scope for activation, which would occur at constant Jmax/p50. Adenosine Diphosphate 59-62 activating signal cointegrator 1 complex subunit 1 Homo sapiens 247-250 8385121-0 1993 Half-stoichiometric trinitrophenylation of myosin subfragment 1 in the presence of pyrophosphate or adenosine diphosphate. Adenosine Diphosphate 100-121 myosin heavy chain 14 Homo sapiens 43-49 8468781-5 1993 This indicates that ARp well reflects the cytosolic redox state, i.e. cytosolic [NAD+]/[NADH], and also [ATP]/[ADP][Pi] theoretically. Adenosine Diphosphate 111-114 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 20-23 8457671-2 1993 We focused on the low affinity complexes of myosin-adenosine triphosphate (ATP) and myosin-adenosine diphosphate (ADP)-Pi with actin filaments since the transition from these states to the high affinity actin-myosin-ADP and actin-myosin states is postulated to generate the molecular motion that drives muscle contraction and other types of cellular movements. Adenosine Diphosphate 114-117 myosin heavy chain 14 Homo sapiens 84-90 9576748-2 1998 Endothelial cell CD39, an ecto-enzyme with ADPase and ATPase activities, rapidly metabolizes ATP and ADP released from activated platelets, thereby abolishing recruitment. Adenosine Diphosphate 43-46 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 17-21 9576748-6 1998 Purified soluble CD39 blocked ADP-induced platelet aggregation in vitro, and inhibited collagen-induced platelet reactivity. Adenosine Diphosphate 30-33 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 17-21 9576748-7 1998 Kinetic analyses indicated that, while soluble CD39 had a Km for ADP of 5.9 microM and for ATP of 2.1 microM, the specificity constant kcat/Km was the same for both substrates. Adenosine Diphosphate 65-68 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 47-51 9508803-9 1998 For both human and murine CFTR, ATP and ADP regulated the rate of exit from the long-lived closed state. Adenosine Diphosphate 40-43 cystic fibrosis transmembrane conductance regulator Mus musculus 26-30 8457671-2 1993 We focused on the low affinity complexes of myosin-adenosine triphosphate (ATP) and myosin-adenosine diphosphate (ADP)-Pi with actin filaments since the transition from these states to the high affinity actin-myosin-ADP and actin-myosin states is postulated to generate the molecular motion that drives muscle contraction and other types of cellular movements. Adenosine Diphosphate 114-117 myosin heavy chain 14 Homo sapiens 84-90 9555058-10 1998 Further, [alpha 32P]ADP and [gamma 32P]ATP incorporated 32P into control brain and purified brain CK equally well, indicating that a mechanism different from gamma-phosphoryl transfer is involved in the enzymatic incorporation of radiolabel. Adenosine Diphosphate 20-23 cytidine/uridine monophosphate kinase 1 Homo sapiens 98-100 9659456-8 1998 Whereas the potency order for stimulation of c-fos expression was ATP = UTP > ADP > adenosine, the potency order to inhibit the NE-induced increase of [3H]thymidine incorporation into DNA was ATP > ADP > UTP > adenosine. Adenosine Diphosphate 81-84 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 45-50 9432026-8 1997 PLA formation by the platelet agonist ADP was inhibited by P-selectin blockade, but enhanced by GPIIb/IIIa blockade (which inhibits platelet-platelet interactions). Adenosine Diphosphate 38-41 integrin subunit alpha 2b Homo sapiens 96-101 9352881-5 1997 The association of PLC-beta1 and Gi/o-type G proteins was studied by pertussis toxin-catalyzed [32P]adenosine diphosphate ribosylation of PLC-beta1 immunoprecipitates. Adenosine Diphosphate 100-121 phospholipase C beta 1 Rattus norvegicus 19-28 9352881-5 1997 The association of PLC-beta1 and Gi/o-type G proteins was studied by pertussis toxin-catalyzed [32P]adenosine diphosphate ribosylation of PLC-beta1 immunoprecipitates. Adenosine Diphosphate 100-121 phospholipase C beta 1 Rattus norvegicus 138-147 1526066-2 1992 Platelet-activating factor (PAF) may be involved in the pathogenesis of asthma, and therefore the effects of the anti-asthma drugs theophylline and enprofylline on human platelet aggregation and adenosine triphosphate (ATP) release induced by PAF and adenosine diphosphate (ADP) were studied. Adenosine Diphosphate 251-272 PCNA clamp associated factor Homo sapiens 0-26 9321400-5 1997 Similar to the action of the GrpE protein on bacterial Hsp70, BAG-1 accelerates the release of ADP from Hsc70. Adenosine Diphosphate 95-98 heat shock protein family A (Hsp70) member 8 Homo sapiens 104-109 9305951-0 1997 X-ray structures of the MgADP, MgATPgammaS, and MgAMPPNP complexes of the Dictyostelium discoideum myosin motor domain. Adenosine Diphosphate 24-29 myosin, heavy chain 10, non-muscle Gallus gallus 99-105 9305951-1 1997 The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II (S1dC) complexed with MgAMPPNP, MgATPgammaS, and MgADP are reported at 2.1, 1.9, and 2.1 A resolution, respectively. Adenosine Diphosphate 151-156 myosin, heavy chain 10, non-muscle Gallus gallus 50-56 1526066-2 1992 Platelet-activating factor (PAF) may be involved in the pathogenesis of asthma, and therefore the effects of the anti-asthma drugs theophylline and enprofylline on human platelet aggregation and adenosine triphosphate (ATP) release induced by PAF and adenosine diphosphate (ADP) were studied. Adenosine Diphosphate 251-272 PCNA clamp associated factor Homo sapiens 28-31 9364473-8 1997 Thus, HEK293 cells apparently express two subtypes of P2Y receptors that respond to ADP or ATP in an additive manner: a P2Y1 receptor, which is selectively activated by 2MeSADP, and a P2Y2 receptor, which is selectively activated by UTP. Adenosine Diphosphate 84-87 purinergic receptor P2Y2 Homo sapiens 184-188 1526066-2 1992 Platelet-activating factor (PAF) may be involved in the pathogenesis of asthma, and therefore the effects of the anti-asthma drugs theophylline and enprofylline on human platelet aggregation and adenosine triphosphate (ATP) release induced by PAF and adenosine diphosphate (ADP) were studied. Adenosine Diphosphate 274-277 PCNA clamp associated factor Homo sapiens 0-26 9134653-9 1997 Plasmin cleaves GPIIb/IIIa so that it becomes a competent fibrinogen receptor, and binding of 125I-fibrinogen during ADP-induced aggregation was greatly potentiated within 10 s. Potentiation of aggregation by other agonists may be due to increased binding of released fibrinogen. Adenosine Diphosphate 117-120 integrin subunit alpha 2b Homo sapiens 16-21 1526066-2 1992 Platelet-activating factor (PAF) may be involved in the pathogenesis of asthma, and therefore the effects of the anti-asthma drugs theophylline and enprofylline on human platelet aggregation and adenosine triphosphate (ATP) release induced by PAF and adenosine diphosphate (ADP) were studied. Adenosine Diphosphate 274-277 PCNA clamp associated factor Homo sapiens 28-31 9134654-7 1997 1.6 x 10(-7)M), however, the number of GPIIb-IIIa receptors per platelet capable of binding fibrinogen was significantly greater in women than men in response to 2 microM ADP (16,319 +/- 1871 vs 9669 +/- 1994, p = 0.02), 20 microM ADP (39,951 +/- 4711 vs 25,948 +/- 4953, p = 0.05) and 50 microM TRAP (39,236 +/- 3965 vs 21,848 +/- 4159, p = 0.007). Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 39-44 9134654-8 1997 Similarly, the number of GPIIb-IIIa receptors capable of binding PAC-1 in response to ADP and TRAP was 50% to 80% greater in women than men. Adenosine Diphosphate 86-89 integrin subunit alpha 2b Homo sapiens 25-30 1386805-2 1992 The Mg-ATPase activity of bound myosin was studied by a coupled enzymatic assay, which detects Mg-ADP in the bulk solution by means of pyruvate kinase and lactate dehydrogenase. Adenosine Diphosphate 95-101 myosin heavy chain 14 Homo sapiens 32-38 9057642-5 1997 Both the rapid decline in agonist-induced [Ca2+]i levels and the impaired prothrombinase activation in delta-SPD platelets were corrected by the addition of adenosine diphosphate (ADP) after stimulation. Adenosine Diphosphate 157-178 coagulation factor X Homo sapiens 74-88 9057642-5 1997 Both the rapid decline in agonist-induced [Ca2+]i levels and the impaired prothrombinase activation in delta-SPD platelets were corrected by the addition of adenosine diphosphate (ADP) after stimulation. Adenosine Diphosphate 180-183 coagulation factor X Homo sapiens 74-88 9057642-6 1997 These findings suggest that secreted ADP may play an important role in the generation of prothrombinase activity by contributing to the maintenance of a critical [Ca2+]i level necessary to maintain aminophospholipids on the outer surface of the platelet membrane, and provide evidence that dense granules may be a major source of ADP which can contribute to calcium influx in stimulated platelets. Adenosine Diphosphate 37-40 coagulation factor X Homo sapiens 89-103 1386805-5 1992 The Mg-ADP produced by myosin ATPase in the vicinity of the film did not diffuse into the bulk solution but, in the presence of creatine phosphate, was recycled into Mg-ATP by the neighbouring creatine kinase. Adenosine Diphosphate 4-10 myosin heavy chain 14 Homo sapiens 23-29 9057642-6 1997 These findings suggest that secreted ADP may play an important role in the generation of prothrombinase activity by contributing to the maintenance of a critical [Ca2+]i level necessary to maintain aminophospholipids on the outer surface of the platelet membrane, and provide evidence that dense granules may be a major source of ADP which can contribute to calcium influx in stimulated platelets. Adenosine Diphosphate 330-333 coagulation factor X Homo sapiens 89-103 1386805-6 1992 The existence of an unstirred layer near the surface of the film is sufficient to explain the channeling of ADP (or ATP) between co-immobilized myosin and creatine kinase, without direct interaction or "intimate coupling" between the enzymes. Adenosine Diphosphate 108-111 myosin heavy chain 14 Homo sapiens 144-150 9029013-9 1997 Moreover, the signals generated by CD9 and PTA1 antigens differed significantly in their sensitivity to PKC inhibition or ADP-ribosylation of the small GTP-binding protein rhoA. Adenosine Diphosphate 122-125 CD9 molecule Homo sapiens 35-38 1617671-11 1992 We observed that Fos protein is weakly poly-ADP-ribosylated in response to active oxygen, but the functional role of this modification remains unclear. Adenosine Diphosphate 44-47 FBJ osteosarcoma oncogene Mus musculus 17-20 9087913-2 1997 Average side views of the three allosteric states (TT, TR, and RR, which correspond to none, one, or both of the two heptameric rings of the GroEL oligomer occupied by nucleotide, respectively) of GroEL and GroEL-GroES complexes for ADP, ATP, and two nonhydrolyzable analogs (AMP-PNP and ATP gamma S) have been obtained at 20-25 A resolution. Adenosine Diphosphate 233-236 heat shock protein family D (Hsp60) member 1 Homo sapiens 197-202 9087913-2 1997 Average side views of the three allosteric states (TT, TR, and RR, which correspond to none, one, or both of the two heptameric rings of the GroEL oligomer occupied by nucleotide, respectively) of GroEL and GroEL-GroES complexes for ADP, ATP, and two nonhydrolyzable analogs (AMP-PNP and ATP gamma S) have been obtained at 20-25 A resolution. Adenosine Diphosphate 233-236 heat shock protein family D (Hsp60) member 1 Homo sapiens 197-202 9119254-6 1997 GGT-stimulation of lipid peroxidation was dependent both on the concentration of GSH and of ADP-chelated iron. Adenosine Diphosphate 92-95 inactive glutathione hydrolase 2 Homo sapiens 0-3 9119254-7 1997 In GGT-rich HepG2 human hepatoma cells, the exposure to GSH, glycyl-glycine, and ADP-chelated iron resulted in a nontoxic lipid peroxidation process, which could be prevented by means of GGT inhibitors such as acivicin and the serine-boric acid complex. Adenosine Diphosphate 81-84 inactive glutathione hydrolase 2 Homo sapiens 3-6 8947491-1 1996 Extracellular ATP and ADP, released from platelets and other sites stimulate the endothelial production of prostacyclin (PGI2) by acting on G-protein-coupled P2Y2 and P2Y2 purinoceptors, contributing to the maintenance of a non-thrombogenic surface. Adenosine Diphosphate 22-25 purinergic receptor P2Y2 Homo sapiens 158-162 8947491-1 1996 Extracellular ATP and ADP, released from platelets and other sites stimulate the endothelial production of prostacyclin (PGI2) by acting on G-protein-coupled P2Y2 and P2Y2 purinoceptors, contributing to the maintenance of a non-thrombogenic surface. Adenosine Diphosphate 22-25 purinergic receptor P2Y2 Homo sapiens 167-171 1323562-4 1992 To obtain further information on the nucleotide binding properties of gelsolin, binding studies were done in the presence of EGTA with GTP, ADP, and GDP by equilibrium dialysis. Adenosine Diphosphate 140-143 gelsolin Homo sapiens 70-78 8836136-0 1996 Regulation of NAD+ glycohydrolase activity by NAD(+)-dependent auto-ADP-ribosylation. Adenosine Diphosphate 68-71 NAD glycohydrolase Oryctolagus cuniculus 14-33 8883549-2 1996 If ATP and bovine serum albumin were present during the isolation procedures mitochondria exhibited ADP sensitive respiration and membrane potentials, comparable to values from other tissues. Adenosine Diphosphate 100-103 albumin Sus scrofa 18-31 1353910-3 1992 EF-2 that has not been posttranslationally modified at histidine 715 is resistant to ADP ribosylation by these toxins. Adenosine Diphosphate 85-88 eukaryotic translation elongation factor 2 Homo sapiens 0-4 8856471-7 1996 We observed significant inhibition of ADP-induced platelet aggregation (-9.9%) and a decrease in plasma fibronectin (-20.2%), thromboxane B2 (TXB2, -20.6%), prostacyclin (-23.2%), and endothelin-1 (ET-1, -17.9%) level. Adenosine Diphosphate 38-41 endothelin-1 Sus scrofa 184-196 1551206-4 1992 Both heparin and hirudin prevented the increase in ADP-induced platelet aggregation normally seen with t-PA alone (p less than 0.01 by t test; p less than 0.05 by two-way analysis of variance). Adenosine Diphosphate 51-54 tissue-type plasminogen activator Oryctolagus cuniculus 103-107 8663320-2 1996 Our characterization of this 66-kDa protein demonstrates that its physiological role is to promote the recycling of hsp 70 by catalyzing the dissociation of hsp 70-bound ADP in exchange for ATP. Adenosine Diphosphate 170-173 heat shock protein family A (Hsp70) member 4 Homo sapiens 116-122 8663320-2 1996 Our characterization of this 66-kDa protein demonstrates that its physiological role is to promote the recycling of hsp 70 by catalyzing the dissociation of hsp 70-bound ADP in exchange for ATP. Adenosine Diphosphate 170-173 heat shock protein family A (Hsp70) member 4 Homo sapiens 157-163 8663320-4 1996 RF-hsp 70 promotes stoichiometric binding of ATP to hsp 70, and it increases about 5-fold the rate of dissociation of hsp 70.ADP in the presence of ATP. Adenosine Diphosphate 125-128 heat shock protein family A (Hsp70) member 4 Homo sapiens 3-9 8663320-4 1996 RF-hsp 70 promotes stoichiometric binding of ATP to hsp 70, and it increases about 5-fold the rate of dissociation of hsp 70.ADP in the presence of ATP. Adenosine Diphosphate 125-128 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-58 1346627-7 1992 Although dopamine synthesis and metabolism had returned to normal by day 7, the in vitro ADP-ribosylation of G proteins in the A10 region by PTX remained depressed by approximately 50% from day 1 to day 14 after administration, returning to normal by day 30. Adenosine Diphosphate 89-92 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 127-130 8663320-4 1996 RF-hsp 70 promotes stoichiometric binding of ATP to hsp 70, and it increases about 5-fold the rate of dissociation of hsp 70.ADP in the presence of ATP. Adenosine Diphosphate 125-128 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-58 8663320-6 1996 The mechanism of action of RF-hsp 70 is to lower the KD of hsp 70 for ATP about 6-7-fold to a value that is close to the KDof hsp 70 for ADP. Adenosine Diphosphate 137-140 heat shock protein family A (Hsp70) member 4 Homo sapiens 30-36 8663320-6 1996 The mechanism of action of RF-hsp 70 is to lower the KD of hsp 70 for ATP about 6-7-fold to a value that is close to the KDof hsp 70 for ADP. Adenosine Diphosphate 137-140 heat shock protein family A (Hsp70) member 4 Homo sapiens 59-65 8663320-6 1996 The mechanism of action of RF-hsp 70 is to lower the KD of hsp 70 for ATP about 6-7-fold to a value that is close to the KDof hsp 70 for ADP. Adenosine Diphosphate 137-140 heat shock protein family A (Hsp70) member 4 Homo sapiens 59-65 8663320-7 1996 RF-hsp 70 also stimulates the ATPase activity of hsp 70, including the 42-kDa amino-terminal portion of hsp 70 generated by chymotrypsin, demonstrating that RF-hsp 70 interacts with that part of hsp 70 known to contain the ATP/ADP binding site. Adenosine Diphosphate 227-230 heat shock protein family A (Hsp70) member 4 Homo sapiens 3-9 8663320-7 1996 RF-hsp 70 also stimulates the ATPase activity of hsp 70, including the 42-kDa amino-terminal portion of hsp 70 generated by chymotrypsin, demonstrating that RF-hsp 70 interacts with that part of hsp 70 known to contain the ATP/ADP binding site. Adenosine Diphosphate 227-230 heat shock protein family A (Hsp70) member 4 Homo sapiens 49-55 8663320-7 1996 RF-hsp 70 also stimulates the ATPase activity of hsp 70, including the 42-kDa amino-terminal portion of hsp 70 generated by chymotrypsin, demonstrating that RF-hsp 70 interacts with that part of hsp 70 known to contain the ATP/ADP binding site. Adenosine Diphosphate 227-230 heat shock protein family A (Hsp70) member 4 Homo sapiens 49-55 8663320-7 1996 RF-hsp 70 also stimulates the ATPase activity of hsp 70, including the 42-kDa amino-terminal portion of hsp 70 generated by chymotrypsin, demonstrating that RF-hsp 70 interacts with that part of hsp 70 known to contain the ATP/ADP binding site. Adenosine Diphosphate 227-230 heat shock protein family A (Hsp70) member 4 Homo sapiens 49-55 8663320-7 1996 RF-hsp 70 also stimulates the ATPase activity of hsp 70, including the 42-kDa amino-terminal portion of hsp 70 generated by chymotrypsin, demonstrating that RF-hsp 70 interacts with that part of hsp 70 known to contain the ATP/ADP binding site. Adenosine Diphosphate 227-230 heat shock protein family A (Hsp70) member 4 Homo sapiens 49-55 8663341-1 1996 Constitutive 70-kDa heat shock protein (hsc70) is a mixture of monomers and oligomers in ADP, while in ATP it is monomeric unless certain DnaJ homologs are present which induce hsc70 to form large polymers in an ATP-dependent reaction. Adenosine Diphosphate 89-92 heat shock protein family A (Hsp70) member 8 Homo sapiens 40-45 1737100-7 1992 In measurements of cytosolic free calcium concentration ([Ca2+]i) by flow cytometry in Indo-1-loaded platelets, ADP"s dose-response for actin polymerization was similar to that for calcium mobilization. Adenosine Diphosphate 112-115 actin Oryctolagus cuniculus 136-141 8699126-3 1996 When anti-CD11a or anti-CD11b was added to neutrophils with PRPr, ATP, or ADP, the adhesion-increasing action was cancelled or considerably repressed. Adenosine Diphosphate 74-77 integrin subunit alpha M Homo sapiens 24-29 8605215-2 1996 In the presence of MgADP, peptide binding is a two-step process; the first step results in a low-affinity peptide-Hsc70 complex (Kd calcd approximately 14 microM), while the second step locks the peptide into a higher-affinity complex (Kd = 4.3 microM). Adenosine Diphosphate 19-24 heat shock protein family A (Hsp70) member 8 Bos taurus 114-119 8605215-4 1996 The bimolecular rates of initial peptide-Hsc70 association differ less than 2-fold in the presence of MgADP and MgATP. Adenosine Diphosphate 102-107 heat shock protein family A (Hsp70) member 8 Bos taurus 41-46 8907715-5 1996 The resulting Hsc70-ADP complex exchanges ATP for ADP. Adenosine Diphosphate 50-53 heat shock protein family A (Hsp70) member 8 Bos taurus 14-19 8907715-6 1996 Dissociation of ATP or ADP from Hsc70 does not seem to occur under physiological conditions. Adenosine Diphosphate 23-26 heat shock protein family A (Hsp70) member 8 Bos taurus 32-37 1737100-8 1992 As shown by flow cytometry, a tail population that had a minimal increase in F-actin upon stimulation with ADP or U46619 also contained the platelets with the least forward and right angle light scattering, which are functions of platelet size and shape. Adenosine Diphosphate 107-110 actin Oryctolagus cuniculus 79-84 9090846-0 1996 Oxygen- and carbon source-dependent transactivation effect of ABF1 on the expression of the AAC2 gene encoding mitochondrial ADP/ATP carrier. Adenosine Diphosphate 125-128 solute carrier family 25 member 5 Homo sapiens 92-96 1559134-0 1992 Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5"-diphosphate. Adenosine Diphosphate 93-117 pyrimidinergic receptor P2Y6 Homo sapiens 15-30 8845369-14 1995 (FGE)3F(GEF)2GD was a competitive inhibitor versus the phosphopeptide and a noncompetitive inhibitor versus MgADP. Adenosine Diphosphate 108-113 sulfatase modifying factor 1 Homo sapiens 1-4 8845369-16 1995 (FGE)3Y(GEF)2GD was a competitive inhibitor against peptide substrate and a noncompetitive inhibitor against MgADP; therefore a dead end complex can form between MgADP, (FGE)3Y(GEF)2GD, and the enzyme. Adenosine Diphosphate 109-114 sulfatase modifying factor 1 Homo sapiens 1-4 8845369-16 1995 (FGE)3Y(GEF)2GD was a competitive inhibitor against peptide substrate and a noncompetitive inhibitor against MgADP; therefore a dead end complex can form between MgADP, (FGE)3Y(GEF)2GD, and the enzyme. Adenosine Diphosphate 109-114 sulfatase modifying factor 1 Homo sapiens 170-173 8845369-16 1995 (FGE)3Y(GEF)2GD was a competitive inhibitor against peptide substrate and a noncompetitive inhibitor against MgADP; therefore a dead end complex can form between MgADP, (FGE)3Y(GEF)2GD, and the enzyme. Adenosine Diphosphate 162-167 sulfatase modifying factor 1 Homo sapiens 1-4 1579893-5 1992 ADP-induced platelet adhesion to collagen was almost completely inhibited by anti-GPIa/IIa and anti-GPIIa antibodies. Adenosine Diphosphate 0-3 multimerin 1 Homo sapiens 82-86 8845369-16 1995 (FGE)3Y(GEF)2GD was a competitive inhibitor against peptide substrate and a noncompetitive inhibitor against MgADP; therefore a dead end complex can form between MgADP, (FGE)3Y(GEF)2GD, and the enzyme. Adenosine Diphosphate 162-167 sulfatase modifying factor 1 Homo sapiens 170-173 1930240-0 1991 Localization of an endogenous ADP-ribose acceptor, p33, in polymorphonuclear cell granules in chicken liver interlobular connective tissue. Adenosine Diphosphate 30-33 leukocyte cell derived chemotaxin 2 Gallus gallus 51-54 8530381-5 1995 Here we demonstrate that the mt-Hsp70.Mim44 complex contains ADP and that a nonhydrolyzable analog of ATP dissociates the mt-Hsp70.Mim44 complex in the presence of potassium ions. Adenosine Diphosphate 61-64 heat shock protein family A (Hsp70) member 4 Homo sapiens 32-37 8530381-5 1995 Here we demonstrate that the mt-Hsp70.Mim44 complex contains ADP and that a nonhydrolyzable analog of ATP dissociates the mt-Hsp70.Mim44 complex in the presence of potassium ions. Adenosine Diphosphate 61-64 heat shock protein family A (Hsp70) member 4 Homo sapiens 125-130 8772233-5 1995 MAb FN52 against CD9 which activates the complement system and produces microvesicles due to a membrane permeabilization, ADP (9.37 microM), and the thrombin receptor agonist peptide SFLLRN (100 microM) that activates platelets via G-proteins were used as inducers. Adenosine Diphosphate 122-125 CD9 molecule Homo sapiens 17-20 8772236-1 1995 We examined interspecies differences in the function of the platelet fibrinogen receptor, GPIIb-IIIa, by comparing platelet aggregation responses to adenosine diphosphate (ADP) added alone or in combination with a GPIIIa specific monoclonal antibody (mAb), D3. Adenosine Diphosphate 149-170 integrin subunit alpha 2b Homo sapiens 90-95 1831057-3 1991 Preincubation of human platelet-rich plasma with rscu-PA/MA-PMI-2, rscu-PA/MA-PMI-1, or unconjugated rscu-PA resulted in partial inhibition of ADP-induced aggregation; 25% inhibition was obtained with 63 micrograms/mL rscu-PA and with 6 micrograms u-PA/mL rscu-PA/MA-PMI-2 or 1.2 micrograms u-PA/mL rscu-PA/MA-PMI-1. Adenosine Diphosphate 143-146 mannose phosphate isomerase Homo sapiens 78-83 7585962-3 1995 While hydrolysis remains the rate-limiting step in the ATPase cycle, Hip stabilizes the ADP state of Hsc70 that has a high affinity for substrate protein. Adenosine Diphosphate 88-91 heat shock protein family A (Hsp70) member 8 Homo sapiens 101-106 1831057-3 1991 Preincubation of human platelet-rich plasma with rscu-PA/MA-PMI-2, rscu-PA/MA-PMI-1, or unconjugated rscu-PA resulted in partial inhibition of ADP-induced aggregation; 25% inhibition was obtained with 63 micrograms/mL rscu-PA and with 6 micrograms u-PA/mL rscu-PA/MA-PMI-2 or 1.2 micrograms u-PA/mL rscu-PA/MA-PMI-1. Adenosine Diphosphate 143-146 mannose phosphate isomerase Homo sapiens 310-315 1860223-7 1991 Ex vivo, ADP-induced platelet aggregation was inhibited by a urokinase-7E3 IgG conjugate at a concentration of 8 nM, whereas a mixture of urokinase and 7E3 (Fab")2 in equimolar amounts required 60 nM and urokinase alone required 1 microM to achieve the same effect. Adenosine Diphosphate 9-12 FA complementation group B Homo sapiens 157-160 8573469-4 1995 GroESL complexes, reconstituted efficiently in vitro from GroEL and GroES in the absence of added ADP or ATP, had the characteristic bullet- and football-like shapes in side view. Adenosine Diphosphate 98-101 chaperonin GroES Escherichia coli 0-5 1832050-0 1991 [Characteristics of affinity modification of myosin ATPase under the action of monoaldehyde derivatives of ADP]. Adenosine Diphosphate 107-110 myosin heavy chain 14 Homo sapiens 45-51 7592744-9 1995 The synergistic activation was inhibited by C3 exoenzyme-catalyzed ADP-ribosylation of recombinant isoprenylated rhoA p21 in a NAD-dependent manner. Adenosine Diphosphate 67-70 KRAS proto-oncogene, GTPase Rattus norvegicus 118-121 1832050-1 1991 It was shown that the highly purified monoaldehyde derivative of ADP obtained by partial reduction of the dialdehyde derivative of ADP causes strong irreversible inhibition of the Ca-ATPase activity of myosin subfragment I, the inhibiting effect being of the affinity modification type. Adenosine Diphosphate 65-68 myosin heavy chain 14 Homo sapiens 202-208 1832050-1 1991 It was shown that the highly purified monoaldehyde derivative of ADP obtained by partial reduction of the dialdehyde derivative of ADP causes strong irreversible inhibition of the Ca-ATPase activity of myosin subfragment I, the inhibiting effect being of the affinity modification type. Adenosine Diphosphate 131-134 myosin heavy chain 14 Homo sapiens 202-208 7588642-7 1995 Specific requirement for ADP as a substrate and its direct incorporation into the 5" end of the primer RNA are also unique properties of the ColE2 Rep protein. Adenosine Diphosphate 25-28 replication protein Escherichia coli 147-150 1991035-8 1991 In this regard, we show that [log[( phosphocreatine]/[creatine]) + log [( ADP]/[ATP])] [the value of which gives [pHi--log (mass action ratio)]] is positively correlated with pHi, although the slope of the line is 0.7, as opposed to the ideal value of unity. Adenosine Diphosphate 74-77 glucose-6-phosphate isomerase Rattus norvegicus 114-117 1991035-8 1991 In this regard, we show that [log[( phosphocreatine]/[creatine]) + log [( ADP]/[ATP])] [the value of which gives [pHi--log (mass action ratio)]] is positively correlated with pHi, although the slope of the line is 0.7, as opposed to the ideal value of unity. Adenosine Diphosphate 74-77 glucose-6-phosphate isomerase Rattus norvegicus 175-178 1902328-4 1991 Platelet aggregation induced by several stimuli (ADP, collagen, arachidonic acid and PAF) was inhibited by increasing concentrations of the drug (1-50 uM); interestingly, the potency of nitroprusside is higher when PAF is employed as stimulating agent in comparison with the other agonists (ED50 = 2 uM for ADP, 2.5 uM for A.A., 4.5 uM for collagen and 0.3 uM for PAF-induced aggregations). Adenosine Diphosphate 307-310 PCNA clamp associated factor Homo sapiens 85-88 2242424-7 1990 In another patient with myelofibrosis and defective aggregation, PAC1 failed to bind to adenosine diphosphate-stimulated platelets, but did bind when protein kinase C was directly activated with phorbol myristate acetate. Adenosine Diphosphate 88-109 ADCYAP receptor type I Homo sapiens 65-69 2176823-7 1990 56, 535-541], demonstrating that the IPSL is oriented on the myosin cross-bridge in a manner that is favorable for detecting cross-bridge rotation during the rigor to MgADP state transition. Adenosine Diphosphate 167-172 myosin heavy chain 14 Homo sapiens 61-67 2212308-1 1990 The acoustic intermodulation distortion product 2f1-f2 (ADP) was measured in human subjects to investigate (1) the dependence of ADP level on stimulus parameters and (2) the relationship between ADP level and auditory sensitivity. Adenosine Diphosphate 56-59 WD and tetratricopeptide repeats 1 Homo sapiens 4-54 2212308-4 1990 Beyond the maximum, the ADP level declines with increasing f2/f1 ratio, at rates of up to 250 dB/oct. Adenosine Diphosphate 24-27 plexin A2 Homo sapiens 97-100 2380264-14 1990 The primary structure of UCP is significantly homologous to the primary structure of the human T1 ADP/ATP carrier, particularly in the C-terminal extremity, which is supposed to contain a nucleotide-binding site in both proteins. Adenosine Diphosphate 98-101 uncoupling protein 1 Homo sapiens 25-28 2291538-2 1990 This effect of ATP appears mediated via a P2-purinoceptor because the rank order of agonist potency is ATP greater than ADP greater than AMP = adenosine. Adenosine Diphosphate 120-123 pyrimidinergic receptor P2Y6 Homo sapiens 42-57 33768253-4 2021 Molecular docking simulations indicated that surfactin could bind to the N-terminal dimerization interface of the cyanobacterial Hsp90 in the ATP- and ADP-bound states, which provided molecular insights into the species-selective inhibition. Adenosine Diphosphate 151-154 heat shock protein 90 alpha family class A member 1 Homo sapiens 129-134 33801254-1 2021 Adenine nucleotide translocase (ANT) is a well-known mitochondrial exchanger of ATP against ADP. Adenosine Diphosphate 92-95 solute carrier family 25 member 6 Homo sapiens 0-30 33801254-1 2021 Adenine nucleotide translocase (ANT) is a well-known mitochondrial exchanger of ATP against ADP. Adenosine Diphosphate 92-95 solute carrier family 25 member 6 Homo sapiens 32-35 33801254-13 2021 ANT"s dual function-ADP/ATP and H+ transport in the presence of FA-may be important for the regulation of mitochondrial membrane potential and thus for potential-dependent processes in mitochondria. Adenosine Diphosphate 20-23 solute carrier family 25 member 6 Homo sapiens 0-3 17349882-7 2007 RESULTS: Platelet activation markers (P-selectin) after stimulation (adenosine diphosphate) were reduced by 40 mg/day of atorvastatin (-5.2 +/- 1.6 arbitrary units) but not by ezetimibe plus low-dose atorvastatin (2.1 +/- 1.8 arbitrary units; p < 0.005) despite a similar reduction of LDL-C (atorvastatin -1.01 +/- 0.18 mmol/l vs. ezetimibe plus atorvastatin -1.36 +/- 0.22 mmol/l, p = NS). Adenosine Diphosphate 69-90 selectin P Homo sapiens 38-48 34748764-1 2021 The mitochondrial ADP/ATP carrier (AAC) performs the first and last step in oxidative phosphorylation by exchanging, ADP and ATP across the mitochondrial inner membrane. Adenosine Diphosphate 117-120 WD and tetratricopeptide repeats 1 Homo sapiens 18-33 34755470-2 2021 ANT1 is involved not only in the processes of ADP/ATP exchange but also in the composition of the mitochondrial membrane permeability transition pore (mPTP); and the function of ANT1 is closely related to its own conformational changes. Adenosine Diphosphate 46-49 solute carrier family 25 member 4 Homo sapiens 0-4 7547949-3 1995 Rg values decrease significantly in the presence of MgATP relative to their values in the presence of MgADP (delta Rg approximately 4-5 A) for Hsc70 and the 60 kDa fragment; in contrast, they are essentially equal in the presence of either nucleotide for the 44 kDa ATPase fragment. Adenosine Diphosphate 102-107 heat shock protein family A (Hsp70) member 8 Bos taurus 143-148 34755470-2 2021 ANT1 is involved not only in the processes of ADP/ATP exchange but also in the composition of the mitochondrial membrane permeability transition pore (mPTP); and the function of ANT1 is closely related to its own conformational changes. Adenosine Diphosphate 46-49 solute carrier family 25 member 4 Homo sapiens 178-182 34880500-4 2021 Here we show that hormonal FABP4 forms a functional hormone complex with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK) to regulate extracellular ATP and ADP levels. Adenosine Diphosphate 171-174 fatty acid binding protein 4 Homo sapiens 27-32 7665563-7 1995 The nucleotide free or ADP-bound form of GroEL also binds to rhodanese that has been either already renatured or never denatured. Adenosine Diphosphate 23-26 heat shock protein family D (Hsp60) member 1 Homo sapiens 41-46 34880500-4 2021 Here we show that hormonal FABP4 forms a functional hormone complex with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK) to regulate extracellular ATP and ADP levels. Adenosine Diphosphate 171-174 cytidine/uridine monophosphate kinase 2 Homo sapiens 100-129 34880500-4 2021 Here we show that hormonal FABP4 forms a functional hormone complex with adenosine kinase (ADK) and nucleoside diphosphate kinase (NDPK) to regulate extracellular ATP and ADP levels. Adenosine Diphosphate 171-174 cytidine/uridine monophosphate kinase 2 Homo sapiens 131-135 7650011-9 1995 These results indicate that GroEL/ES has high and low affinity ADP binding sites and that occupation of the low affinity sites by ADP was responsible for the loss of ability to interact with the substrate protein. Adenosine Diphosphate 63-66 heat shock protein family D (Hsp60) member 1 Homo sapiens 28-33 34410591-8 2021 ADP-mediated P2Y1 and P2Y12 receptor activation contributes to platelet aggregation and targeting P2Y receptors particularly P2Y12 receptor in platelets is effective for the treatment of cardiovascular events. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 13-17 7638601-3 1995 Association of GroES and subsequent ATP hydrolysis in the interacting GroEL toroid resulted in the formation of a stable GroEL:ADP:GroES complex. Adenosine Diphosphate 127-130 chaperonin GroES Escherichia coli 15-20 7638601-3 1995 Association of GroES and subsequent ATP hydrolysis in the interacting GroEL toroid resulted in the formation of a stable GroEL:ADP:GroES complex. Adenosine Diphosphate 127-130 chaperonin GroES Escherichia coli 131-136 34332952-1 2021 Evidence suggests acetylation of human adenine nucleotide translocase 1 (ANT1) at lysine 23 (Lys23) reduces binding of ADP. Adenosine Diphosphate 119-122 solute carrier family 25 member 4 Homo sapiens 39-71 8533137-7 1995 Although SNTX itself could not induce platelet aggregation in rabbit or rat platelet-rich plasma (PRP), it had biphasic effects on collagen- or ADP-induced platelet aggregation in PRP. Adenosine Diphosphate 144-147 proline rich protein 2-like 1 Rattus norvegicus 180-183 34332952-1 2021 Evidence suggests acetylation of human adenine nucleotide translocase 1 (ANT1) at lysine 23 (Lys23) reduces binding of ADP. Adenosine Diphosphate 119-122 solute carrier family 25 member 4 Homo sapiens 73-77 7619795-0 1995 X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-. Adenosine Diphosphate 87-92 myosin, heavy chain 10, non-muscle Gallus gallus 24-30 7619795-0 1995 X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-. Adenosine Diphosphate 102-107 myosin, heavy chain 10, non-muscle Gallus gallus 24-30 7619795-1 1995 The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with beryllium and aluminum fluoride and magnesium ADP are reported at 2.0 and 2.6 A resolution, respectively. Adenosine Diphosphate 153-166 myosin, heavy chain 10, non-muscle Gallus gallus 50-56 7619795-1 1995 The three-dimensional structures of the truncated myosin head from Dictyostelium discoideum myosin II complexed with beryllium and aluminum fluoride and magnesium ADP are reported at 2.0 and 2.6 A resolution, respectively. Adenosine Diphosphate 153-166 myosin, heavy chain 10, non-muscle Gallus gallus 92-98 7619795-5 1995 The tertiary structure of the protein complexed with MgADP.BeFx is essentially identical to that observed previously in the three-dimensional model of chicken skeletal muscle myosin subfragment-1 in which no nucleotide was present. Adenosine Diphosphate 53-58 myosin, heavy chain 10, non-muscle Gallus gallus 175-181 7619795-8 1995 The domain movements observed in the MgADP.AlF4- complex indicate that myosin undergoes a conformational change during hydrolysis that is not associated with the nucleotide binding pocket but rather occurs in the COOH-terminal segment of the myosin motor domain. Adenosine Diphosphate 37-42 myosin, heavy chain 10, non-muscle Gallus gallus 71-77 7619795-8 1995 The domain movements observed in the MgADP.AlF4- complex indicate that myosin undergoes a conformational change during hydrolysis that is not associated with the nucleotide binding pocket but rather occurs in the COOH-terminal segment of the myosin motor domain. Adenosine Diphosphate 37-42 myosin, heavy chain 10, non-muscle Gallus gallus 242-248 7789507-4 1995 However, we find that the SPDP-promoted cross linking of GroES and GroEL occurs in the absence of Mg2+, ADP or ATP, which are required for the formation of the asymmetric complex. Adenosine Diphosphate 104-107 chaperonin GroES Escherichia coli 57-62 7781604-3 1995 Thrombin-induced phosphorylation of SH-PTP1 is an early signalling event (maximal within 10 s) involving neither integrin signalling, nor calcium, nor release of ADP or thromboxane A2. Adenosine Diphosphate 162-165 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 36-43 7760024-5 1995 Evaluation of the functional interaction between PGE1 receptors and Gs by means of receptor-stimulated, cholera toxin-catalyzed ADP-ribosylation of Gs alpha revealed a significant increase in the ability of PGE1 receptors to activate Gs alpha (3.3-fold increase in EC50; p < 0.05) in cells chronically exposed to morphine. Adenosine Diphosphate 128-131 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 148-156 34502546-7 2021 Enhanced mitochondrial dysfunction triggered platelet-mediated Abeta40 aggregate formation through GPVI-mediated ROS production, leading to enhanced integrin alphaIIbbeta3 activation during synergistic stimulation from ADP and Abeta40. Adenosine Diphosphate 219-222 glycoprotein VI platelet Homo sapiens 99-103 7599196-5 1995 One binding site at the heart enzyme is blocked by a monoclonal antibody to subunit VIa-H. ATP (and/or ADP) interact with COX at two or three high-affinity binding sites, as shown by titration of the spectral changes of COX. Adenosine Diphosphate 103-106 cytochrome c oxidase subunit 7A1 Bos taurus 122-125 7599196-5 1995 One binding site at the heart enzyme is blocked by a monoclonal antibody to subunit VIa-H. ATP (and/or ADP) interact with COX at two or three high-affinity binding sites, as shown by titration of the spectral changes of COX. Adenosine Diphosphate 103-106 cytochrome c oxidase subunit 7A1 Bos taurus 220-223 34440901-1 2021 Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. Adenosine Diphosphate 58-61 solute carrier family 25 member 4 Homo sapiens 0-32 7599196-6 1995 Isolated COX from bovine heart was reconstituted with variable intraliposomal ATP/ADP ratios. Adenosine Diphosphate 82-85 cytochrome c oxidase subunit 7A1 Bos taurus 9-12 7794942-11 1995 These results show that ADP binding and photoincorporation are occurring at different sites on the platelet surface but suggest that the ADP binding site may be located in proximity to GPIIb alpha. Adenosine Diphosphate 137-140 integrin subunit alpha 2b Homo sapiens 185-190 34440901-1 2021 Adenine nucleotide translocase 1 (ANT1) transfers ATP and ADP over the mitochondrial inner membrane and thus supplies the cell with energy. Adenosine Diphosphate 58-61 solute carrier family 25 member 4 Homo sapiens 34-38 7482428-5 1995 ADP stimulated only primary, reversible aggregation in rat PRP and whole blood, and these responses were unaffected by alcohol. Adenosine Diphosphate 0-3 proline rich protein 2-like 1 Rattus norvegicus 59-62 34105986-10 2021 Dampening of these danger signals and organ protection largely depends upon activities of vascular and immune cell-expressed ectonucleotidases (CD39 and CD73), which convert ATP and ADP into anti-inflammatory adenosine. Adenosine Diphosphate 182-185 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 144-148 34321462-5 2021 Structural analysis of ARH3 in complex with dimeric ADP-ribose as well as an ADP-ribosylated peptide reveal the molecular basis for the hydrolysis of linear and terminal ADP-ribose linkages. Adenosine Diphosphate 170-173 ADP-ribosylserine hydrolase Homo sapiens 23-27 7896797-9 1995 In contrast, ADP-ribosylation of Rho present in p85 immunoprecipitates is inhibitory. Adenosine Diphosphate 13-16 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 48-51 34261790-3 2021 Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions. Adenosine Diphosphate 196-199 dynamin 1 like Homo sapiens 152-156 34261790-3 2021 Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions. Adenosine Diphosphate 196-199 solute carrier family 25 member 6 Homo sapiens 217-220 34246309-1 2021 BACKGROUND: ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. Adenosine Diphosphate 82-85 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 12-33 34246309-1 2021 BACKGROUND: ADP/ATP translocase 1 (ANT1) is involved in the exchange of cytosolic ADP and mitochondrial ATP, and its defection plays an important role in mitochondrial pathogenesis. Adenosine Diphosphate 82-85 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 35-39 34269454-5 2021 In vitro quality was assessed before and after filtration, and throughout 3 weeks of storage at 4 C. Cell count and hemoglobin levels were determined by hematology analyzer, platelet activation, and responsiveness to ADP by surface expression of P-selectin by flow cytometry, hemolysis by HemoCue, and metabolic parameters by blood gas analyzer. Adenosine Diphosphate 217-220 selectin P Homo sapiens 246-256 34111116-9 2021 Biochemical analysis revealed that the rat-human beta-myosin chimera functioned like the native rat myosin with a 2-fold increase in both motility and in the rate of ADP release from the actin-myosin crossbridge (the step that limits contraction velocity). Adenosine Diphosphate 166-169 myosin heavy chain 14 Homo sapiens 100-106 34111116-9 2021 Biochemical analysis revealed that the rat-human beta-myosin chimera functioned like the native rat myosin with a 2-fold increase in both motility and in the rate of ADP release from the actin-myosin crossbridge (the step that limits contraction velocity). Adenosine Diphosphate 166-169 myosin heavy chain 14 Homo sapiens 193-199 35442654-1 2022 We have designed a protocol combining constant-pH molecular dynamics (CpHMD) simulations with an umbrella sampling (US) scheme (US-CpHMD) to study the mechanism of ADP/ATP transport (import and export) by their inner mitochondrial membrane carrier protein (ADP/ATP carrier (AAC)). Adenosine Diphosphate 164-167 WD and tetratricopeptide repeats 1 Homo sapiens 257-272 35521544-1 2022 The ADP/ATP carrier (AAC) is crucial for mitochondrial functions by importing ADP and exporting ATP across the inner mitochondrial membrane. Adenosine Diphosphate 78-81 WD and tetratricopeptide repeats 1 Homo sapiens 4-19 34718519-8 2022 Isolated islets from beta-PHD1 KO and beta-PHD3 KO had impaired glucose-stimulated insulin secretion and glucose-stimulated increases in the ATP/ADP and NADPH/NADP+ ratio. Adenosine Diphosphate 145-148 egl-9 family hypoxia-inducible factor 3 Mus musculus 43-47 7737177-2 1995 To obtain structural insight on the interaction of the RecA protein with nucleotide cofactors (ATP and ADP) and DNA, we have made two engineered RecA proteins, in which either Tyr103 or Tyr264 was replaced with tryptophan. Adenosine Diphosphate 103-106 RAD51 recombinase Homo sapiens 55-59 7539480-0 1995 Regulation of CFTR Cl- channel gating by ADP and ATP analogues. Adenosine Diphosphate 41-44 cystic fibrosis transmembrane conductance regulator Mus musculus 14-18 7539480-10 1995 ADP competitively inhibited ATP-dependent CFTR channel gating with a Ki of 16 +/- 9 microM. Adenosine Diphosphate 0-3 cystic fibrosis transmembrane conductance regulator Mus musculus 42-46 9363587-13 1995 Activation of intact platelets with ADP resulted in an increased binding of HAG to the platelets, indicating that an augmented Fc gamma R activity is associated with the activation of GPIIb/IIIa. Adenosine Diphosphate 36-39 integrin subunit alpha 2b Homo sapiens 184-189 7981218-11 1994 The kinetic competition data are consistent with the following two-step mechanism for the binding of ATP, ADP, and ATP gamma S, where P is the Rep monomer and A is the adenine nucleotide: P+A [formula: see text] P-A [formula: see text] (P-A). Adenosine Diphosphate 106-109 replication protein Escherichia coli 143-146 7981225-7 1994 For the 44 kDa fragment, Pi release is the slowest step in the ATPase cycle, while for hsc70, Pi release and chemical hydrolysis of MgATP have similar rates; in both cases, ADP release is a relatively rapid step in the ATPase cycle. Adenosine Diphosphate 173-176 heat shock protein family A (Hsp70) member 8 Bos taurus 87-92 7843648-2 1994 An ELISA was developed for directly measuring the expression of glycoprotein IIb/IIIa (GPIIb/IIIa) on platelets in the presence and absence of ADP and under the influence of various heparins. Adenosine Diphosphate 143-146 integrin subunit alpha 2b Homo sapiens 87-97 7883762-6 1994 These results indicate that A23187-induced activation of p72syk is independent of the formation of endoperoxide/thromboxane A2, released ADP and extracellular Ca2+, suggesting the existence of a novel pathway for activation of p72syk. Adenosine Diphosphate 137-140 spleen associated tyrosine kinase Homo sapiens 57-63 8053677-9 1994 The results suggest that the shift of matrix adenine nucleotides from ATP and ADP to AMP preserves the mitochondrial adenine nucleotide pool size during transient hypoxia by preventing net adenine nucleotide transport to the cytoplasm via the ATP-Mg/Pi carrier. Adenosine Diphosphate 78-81 solute carrier family 25 member 25 Rattus norvegicus 243-260 8067390-3 1994 Purinergic receptor agonists inhibited AVP-stimulated Pf with the following rank order efficacy: ATP = ADP = UTP = AMP-PNP = alpha, beta-methylene-ATP > 2-methylthio-ATP >> AMP > adenosine, consistent with the pharmacology of a "nucleotide" receptor subtype. Adenosine Diphosphate 103-106 vasopressin-neurophysin 2-copeptin Oryctolagus cuniculus 39-42 7913554-2 1994 The interaction of the oligomeric bacterial chaperonin GroEL and its cochaperonin, GroES, in the presence of adenosine diphosphate (ADP) forms an asymmetric complex. Adenosine Diphosphate 109-130 heat shock protein family D (Hsp60) member 1 Homo sapiens 55-60 7913554-2 1994 The interaction of the oligomeric bacterial chaperonin GroEL and its cochaperonin, GroES, in the presence of adenosine diphosphate (ADP) forms an asymmetric complex. Adenosine Diphosphate 132-135 heat shock protein family D (Hsp60) member 1 Homo sapiens 55-60 8031127-8 1994 These results suggest that sialosaccharide chains of ADP/Fe(3+)-oxidized erythrocytes, possibly those on glycophorin A, are mainly involved in the recognition by resident macrophages, and poly-N-acetyllactosaminyl saccharide chains, possibly those on band 3, are partly involved in the recognition both by resident and thioglycollate-induced macrophages. Adenosine Diphosphate 53-56 glycophorin A Mus musculus 105-118 8132511-7 1994 When ATP is added to [H163W]recA-ssDNA complexes, there is an immediate quenching of Trp-163 fluorescence (44%) which is intermediate in intensity between that observed with ADP and ATP gamma S. The ATP-induced quenching gradually decreases with time as the pool of ATP is converted to ADP by the ATP hydrolysis activity of the [H163W]recA protein. Adenosine Diphosphate 286-289 RAD51 recombinase Homo sapiens 28-32 8281661-5 1994 METHODS AND RESULTS: DMP 728 demonstrated antiplatelet efficacy in vitro in inhibiting ADP-induced human platelet aggregation (IC50, 46 +/- 2 nmol/L) and fibrinogen binding to human platelets (IC50, 2.3 +/- 0.8 nmol/L) or purified human GPIIb/IIIa receptors (IC50, 0.6 +/- 0.1 nmol/L). Adenosine Diphosphate 87-90 integrin subunit alpha 2b Homo sapiens 237-242 2558726-8 1989 At pD 9.4, ADP was not required in the chase, only Mg2+ or Co2+, making it possible to limit the chase to one turnover from hybrid labeled complexes such as E.K.Mg.CoADP or E.K.Co.MgADP and PEP. Adenosine Diphosphate 11-14 progestagen associated endometrial protein Homo sapiens 190-193 2514650-7 1989 Substances which stimulate release of EDRF include acetylcholine, bradykinin and ADP. Adenosine Diphosphate 81-84 alpha hemoglobin stabilizing protein Homo sapiens 38-42 2620689-10 1989 Platelet-derived adenosine 5"-diphosphate (ADP) is mainly responsible for the stimulation of EDRF production in coronary endothelial cells. Adenosine Diphosphate 17-41 alpha hemoglobin stabilizing protein Homo sapiens 93-97 2620689-10 1989 Platelet-derived adenosine 5"-diphosphate (ADP) is mainly responsible for the stimulation of EDRF production in coronary endothelial cells. Adenosine Diphosphate 43-46 alpha hemoglobin stabilizing protein Homo sapiens 93-97 2620689-13 1989 These data suggest that the ADP released by aggregating platelets stimulates the coronary endothelium to produce EDRF. Adenosine Diphosphate 28-31 alpha hemoglobin stabilizing protein Homo sapiens 113-117 2693515-2 1989 A 20 min in vitro assay, in which a radioactive ADP-ribosyl residue is transferred specifically and 1:1 stoichiometrically to EF-2, is sufficient to estimate the total amounts of ADP-ribosylatable active EF-2. Adenosine Diphosphate 48-51 eukaryotic translation elongation factor 2 Homo sapiens 126-130 2693515-2 1989 A 20 min in vitro assay, in which a radioactive ADP-ribosyl residue is transferred specifically and 1:1 stoichiometrically to EF-2, is sufficient to estimate the total amounts of ADP-ribosylatable active EF-2. Adenosine Diphosphate 179-182 eukaryotic translation elongation factor 2 Homo sapiens 126-130 2693515-2 1989 A 20 min in vitro assay, in which a radioactive ADP-ribosyl residue is transferred specifically and 1:1 stoichiometrically to EF-2, is sufficient to estimate the total amounts of ADP-ribosylatable active EF-2. Adenosine Diphosphate 179-182 eukaryotic translation elongation factor 2 Homo sapiens 204-208 2668261-1 1989 It was reported previously that rat platelets release phospholipase A2 upon in vitro stimulation by thrombin, ADP, or A23187 (Horigome, K., Hayakawa, M., Inoue, K., & Nojima, S. (1987) J. Biochem. Adenosine Diphosphate 110-113 phospholipase A2 group IB Rattus norvegicus 54-70 2930555-1 1989 The amount of protein elongation factor EF-2 that can be inactivated by diphtheria toxin-mediated ADP-ribosylation, a measure of its active content, decreases by 45% and 66% in G1-arrested normal human fibroblasts and in HeLa cells respectively. Adenosine Diphosphate 98-101 eukaryotic translation elongation factor 2 Homo sapiens 40-44 2930555-3 1989 The apparent long half-lives of EF-2 mRNA and protein indicate possibilities of posttranslational ADP-ribosylation and de-ADP-ribosylation as the regulators of the amounts of active EF-2 during human cell cycle. Adenosine Diphosphate 98-101 eukaryotic translation elongation factor 2 Homo sapiens 32-36 2515672-1 1989 Changes in viscous drag acting upon the endothelial lining and a number of circulating agonists (ATP, ADP, serotonin, thrombin) stimulate the release of EDRF from intact endothelial cells. Adenosine Diphosphate 102-105 alpha hemoglobin stabilizing protein Homo sapiens 153-157 3060428-6 1988 Substances that stimulate the release of EDRF include acetylcholine, bradykinin, and adenosine 5"-diphosphate. Adenosine Diphosphate 85-109 alpha hemoglobin stabilizing protein Homo sapiens 41-45 2457583-3 1988 ADP stimulation of platelets results in a fibrinogen-dependent increase in binding of the PMI-1 antibody. Adenosine Diphosphate 0-3 mannose phosphate isomerase Homo sapiens 90-95 21043608-5 1994 The results show that GpIIb/IIIa is involved in mediating the second phase or sustained actin polymerization that occurs after activating platelets with ADP and confirm the requirement for platelet aggregation. Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 22-27 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family D (Hsp60) member 1 Homo sapiens 63-68 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family D (Hsp60) member 1 Homo sapiens 95-100 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 108-111 heat shock protein family D (Hsp60) member 1 Homo sapiens 95-100 3154691-2 1988 Upon stimulation by various factors (viscous drag from increased flow, pulsatile stretch, ADP/ATP, norepinephrine, serotonin), the coronary endothelium releases a vasodilator called endothelium-derived relaxant factor (EDRF). Adenosine Diphosphate 90-93 alpha hemoglobin stabilizing protein Homo sapiens 219-223 7901770-2 1993 GroES and substrate protein counteract each other"s effects on GroEL: whereas GroES stabilizes GroEL in the ADP-bound state, binding of unfolded polypeptide within the cavity of the GroEL cylinder triggers ADP and GroES release. Adenosine Diphosphate 206-209 heat shock protein family D (Hsp60) member 1 Homo sapiens 63-68 7901770-3 1993 Upon ADP-ATP exchange, GroES reassociates with GroEL and ATP hydrolysis discharges the bound protein for folding. Adenosine Diphosphate 5-8 heat shock protein family D (Hsp60) member 1 Homo sapiens 47-52 3390156-8 1988 Calcium mobilization and secretion induced by low concentrations of cathepsin G were partially dependent on arachidonic acid metabolites and ADP, while stimulation by higher enzyme concentrations was independent of amplification pathways, indicating that cathepsin G is a strong platelet agonist. Adenosine Diphosphate 141-144 cathepsin G Homo sapiens 68-79 3276353-1 1988 The binding of glucose, ADP and AdoPP[NH]P, to the native PII dimer and PII monomer and the proteolytically-modified SII monomer of hexokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) from Saccharomyces cerevisiae was monitored at pH 6.7 by the concomitant quenching of protein fluorescence. Adenosine Diphosphate 24-27 hexokinase Saccharomyces cerevisiae S288C 132-142 3276353-7 1988 In the presence of 6 mM ADP or 2 mM AdoPP[NH]P, Qmax for glucose was increased by up to 4% and [L]0.5 was diminished 3-fold for hexokinase PII monomer, 6-fold for SII monomer, and 15-fold for PII dimer. Adenosine Diphosphate 24-27 hexokinase Saccharomyces cerevisiae S288C 128-138 2840374-5 1988 Studying the ADP-induced fibrinogen binding to platelets in vivo, we were able to show that the effect of heparin on platelets is antibody- and antithrombin-III-independent. Adenosine Diphosphate 13-16 serpin family C member 1 Homo sapiens 144-160 2452616-1 1987 The effect of nucleotides: AMP, cAMP, ADP, ATP, GDP and GTP, on glutamate dehydrogenase (GDH) purified from the mealworm fat body was studied. Adenosine Diphosphate 38-41 glutamate dehydrogenase 1 Homo sapiens 89-92 2452616-3 1987 GDH was partially protected from the inhibition by the addition of ADP to an assay medium. Adenosine Diphosphate 67-70 glutamate dehydrogenase 1 Homo sapiens 0-3 2452616-5 1987 The concerted effects of ADP and ATP indicate the importance of adenylate energy charge in the regulation of fat body GDH. Adenosine Diphosphate 25-28 glutamate dehydrogenase 1 Homo sapiens 118-121 3040750-2 1987 The inhibition was well correlated with the toxin-induced ADP-ribosylation of a membrane GTP-binding protein with Mr = 41,000. Adenosine Diphosphate 58-61 RAB2A, member RAS oncogene family Mus musculus 89-108 3663603-0 1987 Probe studies of the MgADP state of muscle cross-bridges: microscopic and wavelength-dependent fluorescence polarization from 1,5-IAEDANS-labeled myosin subfragment 1 decorating muscle fibers. Adenosine Diphosphate 21-26 myosin heavy chain 14 Homo sapiens 146-152 3801462-2 1987 In the hexokinase system, ADP is produced extramitochondrially by added yeast hexokinase, whereas in the creatine kinase system mitochondrial creatine kinase is responsible for ADP regeneration in the intermembrane space. Adenosine Diphosphate 26-29 hexokinase Saccharomyces cerevisiae S288C 7-17 3801462-2 1987 In the hexokinase system, ADP is produced extramitochondrially by added yeast hexokinase, whereas in the creatine kinase system mitochondrial creatine kinase is responsible for ADP regeneration in the intermembrane space. Adenosine Diphosphate 26-29 hexokinase Saccharomyces cerevisiae S288C 78-88 3801462-4 1987 Near the resting state, higher [ATP]/[ADP] ratios were found in the creatine kinase system than in the hexokinase system at the same rate of respiration. Adenosine Diphosphate 38-41 hexokinase Saccharomyces cerevisiae S288C 103-113 3768528-4 1986 The aggregation of human platelets induced by mutant Re595 was divalent cation-dependent and required secretion of ADP and fibrinogen from platelet storage granules because it was inhibited by chelators, by the ADP-splitting enzyme apyrase, and by monospecific antifibrinogen Fab fragments. Adenosine Diphosphate 115-118 FA complementation group B Homo sapiens 276-279 3770459-1 1986 Data obtained by the intrinsic protein fluorescence technique showed that, in addition to Ca2+ and Mg2+ ions, bovine alpha-lactalbumin also binds physiologically significant Na+ and K+ ions, the nucleotides ATP, ADP, UTP, UDP and UDP-galactose. Adenosine Diphosphate 212-215 lactalbumin alpha Bos taurus 117-134 3522566-6 1986 These results indicate that myosin light chain kinase can catalyze a reverse reaction and form ATP from ADP and phosphorylated substrate. Adenosine Diphosphate 104-107 myosin light chain kinase Homo sapiens 28-53 3522566-9 1986 For the forward reaction, measured with both isolated light chains and intact myosin, KmATP is approximately 100 microM and ADP is a competitive inhibitor, KiADP approximately 140 microM (myosin) and 120 microM (light chains). Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 78-84 3522566-9 1986 For the forward reaction, measured with both isolated light chains and intact myosin, KmATP is approximately 100 microM and ADP is a competitive inhibitor, KiADP approximately 140 microM (myosin) and 120 microM (light chains). Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 188-194 8250871-1 1993 In the presence of glycogen, ADP, phosphoglucomutase and hexokinase, the glycogen phosphorylase b activity associated to sarcoplasmic reticulum (SR) membranes stimulates Ca2+ uptake by SR membrane fragments in the absence of added ATP. Adenosine Diphosphate 29-32 glycogen phosphorylase B Homo sapiens 73-97 2938630-4 1986 The subsequent addition of EGTA and ADP induced triphasic EP dephosphorylation. Adenosine Diphosphate 36-39 prostaglandin E receptor 1 Homo sapiens 58-60 8325838-4 1993 Time- and calcium-dependent vesiculation of platelets in response to ADP, collagen, thrombin, phorbol myristate acetate, and the thrombin peptide SFLLRN were dramatically inhibited, in a concentration-dependent manner, by monoclonal antibodies to GPIIb-IIIa (A2A9, 7E3, PAC1) and RGDS. Adenosine Diphosphate 69-72 integrin subunit alpha 2b Homo sapiens 247-252 8237394-3 1993 The solution of PRP clots incubated either alone (as control) or with urokinase or streptokinase 2000 IU.ml-1 at 37 degrees C for 45 min potentiated the increase of platelet aggregation and MDA formation and produced a persistently high level of [Ca2+]i stimulated by thrombin, and platelet aggregation induced by ADP. Adenosine Diphosphate 314-317 proline rich protein 2-like 1 Rattus norvegicus 16-19 8477727-1 1993 The AAC3 gene of Saccharomyces cerevisiae encodes a mitochondrial ADP/ATP translocator which is subject to oxygen repression. Adenosine Diphosphate 66-69 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 4-8 2427294-0 1986 [The ADP-ribosylation site and RNA-binding center are located in different regions of the elongation factor EF-2]. Adenosine Diphosphate 5-8 eukaryotic translation elongation factor 2 Homo sapiens 108-112 7680658-6 1993 Concomitant with this ADP ribosylation, PMA-induced LFA-1/intercellular adhesion molecule (ICAM)-1-dependent aggregation of JY cells was inhibited. Adenosine Diphosphate 22-25 intercellular adhesion molecule 1 Homo sapiens 52-98 8441181-5 1993 Both phosphorylated TnI and TnT inhibited the Ca(2+)-stimulated binding of S-1.ADP to regulated actin, consistent with the notion that the effects of phosphorylation of TnI and TnT affected interactions of the thin filament with the thick filament. Adenosine Diphosphate 79-82 troponin T3, fast skeletal type Rattus norvegicus 28-31 1280114-6 1992 Inhibition of the eukaryotic enzyme was also accompanied by an increase in the abundance of Gs alpha, whether measured by Western blotting with anti-Gs alpha antibody (two separate antisera) or by cholera toxin-dependent [32P]ADP-ribosylation. Adenosine Diphosphate 226-229 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 92-100 1356434-0 1992 Unfolded proteins stimulate molecular chaperone Hsc70 ATPase by accelerating ADP/ATP exchange. Adenosine Diphosphate 77-80 heat shock protein family A (Hsp70) member 8 Homo sapiens 48-53 1356434-7 1992 Release of [3H]ADP from Hsc70 was most efficient in the presence of other nucleotides such as ADP or ATP, suggesting that ADP release occurs as an ADP/ATP exchange reaction. Adenosine Diphosphate 15-18 heat shock protein family A (Hsp70) member 8 Homo sapiens 24-29 1356434-7 1992 Release of [3H]ADP from Hsc70 was most efficient in the presence of other nucleotides such as ADP or ATP, suggesting that ADP release occurs as an ADP/ATP exchange reaction. Adenosine Diphosphate 94-97 heat shock protein family A (Hsp70) member 8 Homo sapiens 24-29 1356434-7 1992 Release of [3H]ADP from Hsc70 was most efficient in the presence of other nucleotides such as ADP or ATP, suggesting that ADP release occurs as an ADP/ATP exchange reaction. Adenosine Diphosphate 94-97 heat shock protein family A (Hsp70) member 8 Homo sapiens 24-29 1356434-7 1992 Release of [3H]ADP from Hsc70 was most efficient in the presence of other nucleotides such as ADP or ATP, suggesting that ADP release occurs as an ADP/ATP exchange reaction. Adenosine Diphosphate 94-97 heat shock protein family A (Hsp70) member 8 Homo sapiens 24-29 1356434-8 1992 The loss of radiolabeled ADP from Hsc70 in the presence of exogenous nucleotides followed first-order kinetics. Adenosine Diphosphate 25-28 heat shock protein family A (Hsp70) member 8 Homo sapiens 34-39 1356434-9 1992 In the presence of nucleotides, apocytochrome c induced a 2-fold increase in the rate of ADP release from Hsc70. Adenosine Diphosphate 89-92 heat shock protein family A (Hsp70) member 8 Homo sapiens 106-111 1356434-11 1992 The results suggest that ADP release in a rate-limiting step in the Hsc70 ATPase reaction and that unfolded proteins stimulate ATP hydrolysis by accelerating the rate of ADP/ATP exchange. Adenosine Diphosphate 25-28 heat shock protein family A (Hsp70) member 8 Homo sapiens 68-73 1356434-11 1992 The results suggest that ADP release in a rate-limiting step in the Hsc70 ATPase reaction and that unfolded proteins stimulate ATP hydrolysis by accelerating the rate of ADP/ATP exchange. Adenosine Diphosphate 170-173 heat shock protein family A (Hsp70) member 8 Homo sapiens 68-73 1381275-11 1992 Acidic FGF-PE with a mutation in the ADP ribosylation domain of PE was inactive in both 2-dimensional and 3-dimensional cultures. Adenosine Diphosphate 37-40 fibroblast growth factor 1 Rattus norvegicus 7-10 1520873-7 1992 LAMP-2 surface expression was minimal in response to platelet stimulation by weak agonists such as epinephrine and ADP. Adenosine Diphosphate 115-118 lysosomal associated membrane protein 2 Homo sapiens 0-6 1322037-5 1992 The ADP ribosylation data show that Gs alpha was more highly labeled in the tissues of the db/db mutant than in the homozygous control, but there was no significant difference in the amount of ADP-ribose incorporated in the Gi alpha-subunits. Adenosine Diphosphate 4-7 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 36-44 1567815-6 1992 This chimeric toxin, termed PE1-412-Bar, is cytotoxic to a murine fibroblast cell line and to a murine hybridoma resistant to the ADP-ribosylation activity of PE. Adenosine Diphosphate 130-133 ets variant 3 Mus musculus 28-31 1388056-10 1992 The changes in PRP and EDP correlated with the cytosolic [ATP]/[ADP] ratio in such a way that the decrease in the latter was associated with a decrease in PRP and the elevation of EDP. Adenosine Diphosphate 64-67 proline rich protein 2-like 1 Rattus norvegicus 15-18 1388056-10 1992 The changes in PRP and EDP correlated with the cytosolic [ATP]/[ADP] ratio in such a way that the decrease in the latter was associated with a decrease in PRP and the elevation of EDP. Adenosine Diphosphate 64-67 proline rich protein 2-like 1 Rattus norvegicus 155-158 1731253-2 1992 It is an allosteric enzyme: the ATPase activity is DNA-dependent, and ATP-bound recA protein has a high affinity for DNA, whereas the ADP-bound form has a low affinity. Adenosine Diphosphate 134-137 RAD51 recombinase Homo sapiens 80-84 1731253-5 1992 Here we determine the position of bound ADP diffused into the recA crystal. Adenosine Diphosphate 40-43 RAD51 recombinase Homo sapiens 62-66 1915842-1 1991 All three genes (AAC1, AAC2 and AAC3) encoding the mitochondrial ADP/ATP translocator, were inactivated in a haploid yeast strain by a gene disruption technique. Adenosine Diphosphate 65-68 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 17-21 1915842-1 1991 All three genes (AAC1, AAC2 and AAC3) encoding the mitochondrial ADP/ATP translocator, were inactivated in a haploid yeast strain by a gene disruption technique. Adenosine Diphosphate 65-68 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 32-36 1905716-10 1991 As an alternative assay for these interactions, we have examined pertussis toxin-catalyzed ADP-ribosylation of the Gt alpha subunit which is markedly enhanced in rate by beta gamma subunits. Adenosine Diphosphate 91-94 integrin subunit alpha 2b Homo sapiens 115-123 2064610-3 1991 The epitope recognized by our monoclonal antibody, CS-1, which substantially inhibits fibrin(ogen) binding to ADP- and thrombin-stimulated platelets [Ramsamooj, Doellgast & Hantgan (1990) Thromb. Adenosine Diphosphate 110-113 chorionic somatomammotropin hormone 1 Homo sapiens 51-55 2005093-1 1991 ATP-G-actin in the absence of excess ATP and divalent metal ions was treated with ADP in amounts large enough to ensure complete formation of ADP-G-actin. Adenosine Diphosphate 82-85 N-methylpurine DNA glycosylase Homo sapiens 142-147 2167309-3 1990 AAC1 and AAC2 genes in yeast each encode functional ADP/ATP carrier (AAC) proteins of the mitochondrial inner membrane. Adenosine Diphosphate 52-55 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 0-4 2271526-2 1990 Longitudinal assembly and disassembly of recA protein filaments mediated by ATP and ADP. Adenosine Diphosphate 84-87 RAD51 recombinase Homo sapiens 41-45 2271526-3 1990 There are at least two major conformations of recA nucleoprotein filaments formed on poly-(deoxythymidylic acid) [poly(dT)], one stabilized by ATP [or adenosine 5"-O-(3-thiotriphosphate) (ATP gamma S)] and one stabilized by ADP. Adenosine Diphosphate 224-227 RAD51 recombinase Homo sapiens 46-50 2271526-7 1990 When a mixture of ATP and ADP is present, recA protein binding is a function of the ADP/ATP ratio. Adenosine Diphosphate 26-29 RAD51 recombinase Homo sapiens 42-46 2271526-7 1990 When a mixture of ATP and ADP is present, recA protein binding is a function of the ADP/ATP ratio. Adenosine Diphosphate 84-87 RAD51 recombinase Homo sapiens 42-46 2117441-6 1990 Preincubation of isolated pancreatic membranes with cholecystokinin octapeptide (CCK-OP), which stimulates phospholipase C in acinar cells, decreased CT-induced as well as PT-induced ADP-ribosylation of the three 40/41 kDa proteins, whereas CT-induced ADP-ribosylation of one 45 kDa (pI 5.80) and all 48 kDa proteins was enhanced in the presence of CCK. Adenosine Diphosphate 183-186 cholecystokinin Rattus norvegicus 52-67 2117441-6 1990 Preincubation of isolated pancreatic membranes with cholecystokinin octapeptide (CCK-OP), which stimulates phospholipase C in acinar cells, decreased CT-induced as well as PT-induced ADP-ribosylation of the three 40/41 kDa proteins, whereas CT-induced ADP-ribosylation of one 45 kDa (pI 5.80) and all 48 kDa proteins was enhanced in the presence of CCK. Adenosine Diphosphate 183-186 cholecystokinin Rattus norvegicus 81-84 3902833-7 1985 When insulin and angiotensinogen were used as substrate, ATP, other nucleoside triphosphates, ADP, inorganic triphosphate, pyrophosphate, and phosphate were effective. Adenosine Diphosphate 94-97 insulin Bos taurus 5-12 2169582-0 1990 [Interaction of protein RecA with ADP (ATP): the mechanism of the ATPase reaction]. Adenosine Diphosphate 34-37 RAD51 recombinase Homo sapiens 24-28 2169582-1 1990 Structure of the RecA x ADP(ATP) and recA x ADP x cation(+2) complexes was studied by methods of ESR, NMR and near-ultraviolet spectroscopy. Adenosine Diphosphate 24-27 RAD51 recombinase Homo sapiens 17-21 2316676-7 1990 Infusion of ADA potentiated changes in [ATP]/[ADP] [Pi] and [AMP] observed during ISO infusion and hypoxia (P less than 0.05). Adenosine Diphosphate 46-49 adenosine deaminase Rattus norvegicus 12-15 2411729-7 1985 Platelets stimulated with ADP or epinephrine bind 10,000-15,000 125I-PAC-1 molecules/platelet while platelets stimulated with thrombin bind 20,000-25,000 molecules/platelet. Adenosine Diphosphate 26-29 ADCYAP receptor type I Homo sapiens 69-74 2306207-8 1990 The timing of the delayed event appears to be modulated by [Ca2+]i: the delayed phase of Mn2+ quench coincides with discharge of the intracellular stores in the absence of added Ca2+, but with the second phase of the ADP-evoked rise in [Ca2+]i in the presence of extracellular Ca2+. Adenosine Diphosphate 217-220 carbonic anhydrase 2 Homo sapiens 60-63 3890954-2 1985 Both the muscle and the yeast pyruvate kinase interact with either ADP or phosphoenolpyruvate with similar affinity, indicating that the substrate-binding sites for these two isozymes are similar. Adenosine Diphosphate 67-70 pyruvate kinase PKLR Oryctolagus cuniculus 30-45 1691675-9 1990 These heterologous effects observed in NG108-15 cells following iloprost pretreatment may involve changes in the GS alpha protein, since there was a reduction of about 30% in the cholera toxin-induced [32P]-ADP-ribosylation of a 45 kDa protein from cell membranes (corresponding to the extent of loss of NECA or NaF responsiveness). Adenosine Diphosphate 207-210 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 113-121 2110108-2 1990 The results suggest that NADPH- and ADP--Fe3(+)-dependent lipid peroxidation involves both NADPH--cytochrome P450 reductase and cytochrome P450. Adenosine Diphosphate 26-29 cytochrome p450 oxidoreductase Rattus norvegicus 91-123 2984303-1 1985 Zymosan particle-stimulated beta-galactosidase secretion by mouse peritoneal macrophages was found to be inhibited by micromolar concentrations of adenosine, AMP, ADP, and ATP. Adenosine Diphosphate 163-166 galactosidase, beta 1 Mus musculus 28-46 2984303-3 1985 The inhibition of lysosomal enzyme secretion by ATP, ADP, and AMP was reversed by adding alpha, beta -methylene ADP (100 microM), a 5"-nucleotidase inhibitor, to the incubation medium. Adenosine Diphosphate 53-56 5' nucleotidase, ecto Mus musculus 132-147 2149400-1 1990 The ATPase activity of RecA protein was examined by monitoring the changes of NMR phosphorus signals of ATP, ADP and inorganic phosphate. Adenosine Diphosphate 109-112 RAD51 recombinase Homo sapiens 23-27 3987690-0 1985 Localization of the sites of ADP-ribosylation and GTP binding in the eukaryotic elongation factor EF-2. Adenosine Diphosphate 29-32 eukaryotic translation elongation factor 2 Homo sapiens 98-102 34941000-3 2022 It is well established that Hsp70s use the energy of ATP hydrolysis to ADP to power the chaperone activity regardless of the cellular locations and isoforms. Adenosine Diphosphate 71-74 heat shock protein family A (Hsp70) member 4 Homo sapiens 28-33 3987690-8 1985 Correspondingly, tryptic degradation of EF-2 labelled with [14C]NAD+ in the presence of diphtheria toxin showed that the site of ADP-ribosylation was within the 34-kDa polypeptide. Adenosine Diphosphate 129-132 eukaryotic translation elongation factor 2 Homo sapiens 40-44 34788986-0 2022 GNE-related thrombocytopenia: evidence for a mutational hotspot in the ADP/substrate domain of the GNE bifunctional enzyme. Adenosine Diphosphate 71-74 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 0-3 3967486-3 1985 Using potassium ferricyanide or trypsin-solubilized liver cytochrome b5 (Tb5) as substrates, enzyme activity was inhibited by ADP and to a lesser extent by ATP. Adenosine Diphosphate 126-129 cytochrome b5 type A Homo sapiens 58-71 34788986-0 2022 GNE-related thrombocytopenia: evidence for a mutational hotspot in the ADP/substrate domain of the GNE bifunctional enzyme. Adenosine Diphosphate 71-74 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Homo sapiens 99-102 6324346-1 1984 A mouse monoclonal antibody that reacts with beta 2-microglobulin, the light chain of class I major histocompatibility antigens, inhibited the second wave of human platelet aggregation induced by adenosine diphosphate and epinephrine and blocked aggregation and platelet protein phosphorylation induced by sodium arachidonate. Adenosine Diphosphate 196-217 beta-2-microglobulin Homo sapiens 45-65 34750509-6 2021 These observations suggest that PARP1/HPF1-mediated serine ADP-ribosylation, when driven by SIRT inhibition, can inadvertently inhibit the growth of BRCA-gene mutant cells. Adenosine Diphosphate 59-62 BRCA1 DNA repair associated Homo sapiens 149-153 6427766-8 1984 It was confirmed by using two-dimensional gel electrophoresis that PA toxin resistance in hybrid cells was caused by the presence of EF-2 resistant to ADP-ribosylation by fragment A of diphtheria toxin. Adenosine Diphosphate 151-154 eukaryotic translation elongation factor 2 Homo sapiens 133-137 34770786-9 2021 Preliminary molecular docking assay showed that BA can bind to the nucleotide binding domain of the HSP70 at its ADP-bound state of the HSP70. Adenosine Diphosphate 113-116 heat shock protein family A (Hsp70) member 4 Homo sapiens 100-105 34770786-9 2021 Preliminary molecular docking assay showed that BA can bind to the nucleotide binding domain of the HSP70 at its ADP-bound state of the HSP70. Adenosine Diphosphate 113-116 heat shock protein family A (Hsp70) member 4 Homo sapiens 136-141 34712849-7 2021 PAPSS is an, unique enzyme that binds to four different nucleotides: ATP and APS on both ATPS and APSK domains and ADP and PAPS exclusively on the APSK domain. Adenosine Diphosphate 115-118 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 0-5 6308003-3 1983 Anti-intact, anti-chymotrypsin, and anti-pronase-treated platelet membrane antibodies (IgG and Fab fragments) inhibited the fibrinogen-induced aggregation of ADP-stimulated platelets and of chymotrypsin-treated platelets. Adenosine Diphosphate 158-161 FA complementation group B Homo sapiens 95-98 34160117-12 2021 DENV NS1 induce a stable platelet aggregation after the addition of a minimal dose of adenosine diphosphate (ADP), epinephrine (EPI) and collagen. Adenosine Diphosphate 109-112 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 5-8 6134642-2 1983 Treatment of cyc- cells with islet-activating protein (IAP), which causes ADP-ribosylation of an Mr 40 000 polypeptide in cyc- membranes, abolishes adenylate cyclase inhibition by GTP and the peptide hormone, somatostatin, but not that induced by GTP gamma S. Furthermore, somatostatin-induced stimulation of GTP hydrolysis is lost. Adenosine Diphosphate 74-77 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 13-16 34400216-12 2021 When myotubes were treated with dinitrophenol (mitochondrial uncoupler), AMPD3 overexpression blunted decreases in ATP/ADP and ATP/AMP ratios but exacerbated AdN degradation. Adenosine Diphosphate 119-122 adenosine monophosphate deaminase 3 Mus musculus 73-78 34516596-6 2021 Specifically, we found that glucose oxidase and hexokinase fragment in the presence of D-glucose but not L-glucose, while hexokinase aggregates in the presence of Mg2+ ion and either ATP or ADP at low pH. Adenosine Diphosphate 190-193 hydroxyacid oxidase 1 Homo sapiens 28-43 6134642-2 1983 Treatment of cyc- cells with islet-activating protein (IAP), which causes ADP-ribosylation of an Mr 40 000 polypeptide in cyc- membranes, abolishes adenylate cyclase inhibition by GTP and the peptide hormone, somatostatin, but not that induced by GTP gamma S. Furthermore, somatostatin-induced stimulation of GTP hydrolysis is lost. Adenosine Diphosphate 74-77 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 122-125 6224516-1 1983 The covalent binding of dialdehyde derivatives of ATP and ADP (o-ATP and o-ADP) results in inactivation of chloroplast CF1-ATPase, the degree of inactivation being increased at a rise in temperature and pH. Adenosine Diphosphate 58-61 WD and tetratricopeptide repeats 1 Homo sapiens 73-78 6300694-5 1983 We show here that cyc- S49 cells contain a substrate for ADP-ribosylation by pertussis toxin and that the toxin alters GTP dependent inhibition of cyc- adenyl cyclase activity. Adenosine Diphosphate 57-60 peptidylprolyl isomerase A, pseudogene 1 Mus musculus 18-21 34260389-7 2021 However, compared to no treatment, the addition of DNase-I was sufficient to cleave ATP and adenosine diphosphate (ADP) in adenosine. Adenosine Diphosphate 115-118 deoxyribonuclease I Mus musculus 51-58 34260389-8 2021 Human and mouse platelet aggregation by ADP and neutrophil activation by ATP were also significantly reduced in the presence of DNase-I. Adenosine Diphosphate 40-43 deoxyribonuclease I Mus musculus 128-135 34260389-10 2021 Treatment with DNase-I induces the hydrolysis of ATP and ADP, leading to the generation of adenosine and the inhibition of thrombus formation in vivo. Adenosine Diphosphate 57-60 deoxyribonuclease I Mus musculus 15-22 6648984-2 1983 T-2 toxin (2.2 mM) inhibited oxygen consumption by 40% in ADP-coupled and DNP-uncoupled mitochondria using either succinate or pyridine-nucleotide linked substrates. Adenosine Diphosphate 58-61 brachyury 2 Rattus norvegicus 0-3 34121449-5 2021 In contrast, maximal ADP-stimulated respiration with complex I and II substrates (CON: 23.6 +- 6.6 and SMO: 19.2 +- 8.2 rhoM mg-1 s-1) or octanoylcarnitine (CON: 21.8 +- 9.0 and SMO: 16.5 +- 6.6 rhoM mg-1 s-1) measured in permeabilized muscle fibers, as well as citrate synthase activity, were not significantly different between groups. Adenosine Diphosphate 21-24 ras homolog family member D Mus musculus 120-124 7117236-1 1982 The fluorescent ADP analogue, 1:N6-ethenoadenosine 5"-diphosphate, was incorporated into F-actin in a myosin-free ghost single fibre. Adenosine Diphosphate 16-19 myosin heavy chain 14 Homo sapiens 102-108 34121449-5 2021 In contrast, maximal ADP-stimulated respiration with complex I and II substrates (CON: 23.6 +- 6.6 and SMO: 19.2 +- 8.2 rhoM mg-1 s-1) or octanoylcarnitine (CON: 21.8 +- 9.0 and SMO: 16.5 +- 6.6 rhoM mg-1 s-1) measured in permeabilized muscle fibers, as well as citrate synthase activity, were not significantly different between groups. Adenosine Diphosphate 21-24 ras homolog family member D Mus musculus 195-199 34239878-3 2021 AMPK signaling also modulates energy metabolism in organs such as adipose tissue, brain, muscle, and heart, which are highly dependent on energy consumption via adjusting the AMP/ADP:ATP ratio. Adenosine Diphosphate 179-182 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-4 7115298-7 1982 It was decreased 6-fold when MgADP or Mg[beta gamma-imido]ATP bound to myosin. Adenosine Diphosphate 29-34 myosin heavy chain 14 Homo sapiens 71-77 6121802-2 1982 5-Oxoprolinase catalyzes the coupled hydrolysis of ATP and 5-oxoproline to yield glutamate, ADP, and Pi; the reaction may be partially or completely uncoupled by structural modification of either substrate. Adenosine Diphosphate 92-95 5-oxoprolinase, ATP-hydrolysing Homo sapiens 0-14 35413247-6 2022 On the other hand, here we demonstrated that adenine nucleotides, such as AMP, ADP and ATP, induce the SDH activity provided by the SDH1 subunit. Adenosine Diphosphate 79-82 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 103-106 35413247-6 2022 On the other hand, here we demonstrated that adenine nucleotides, such as AMP, ADP and ATP, induce the SDH activity provided by the SDH1 subunit. Adenosine Diphosphate 79-82 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 132-136 35523052-7 2022 From the light transmission aggregometry analysis, it was found that the maximal extent of aggregation for adenosine diphosphate (ADP) was significantly higher with dabigatran than with FXa inhibitors, and the ED50 value of ADP on platelet aggregation was significantly lower with dabigatran than with FXa inhibitors. Adenosine Diphosphate 130-133 coagulation factor X Homo sapiens 186-189 7112508-1 1982 Using a platelet-rich plasma (PRP) preparation, platelets from subjects with familial hypercholesterolemia (FH) were found to be more reactive to the aggregating agents epinephrine, ADP and thrombin than platelets obtained from normal individuals. Adenosine Diphosphate 182-185 low density lipoprotein receptor Homo sapiens 77-106 35523052-7 2022 From the light transmission aggregometry analysis, it was found that the maximal extent of aggregation for adenosine diphosphate (ADP) was significantly higher with dabigatran than with FXa inhibitors, and the ED50 value of ADP on platelet aggregation was significantly lower with dabigatran than with FXa inhibitors. Adenosine Diphosphate 130-133 coagulation factor X Homo sapiens 302-305 35523052-7 2022 From the light transmission aggregometry analysis, it was found that the maximal extent of aggregation for adenosine diphosphate (ADP) was significantly higher with dabigatran than with FXa inhibitors, and the ED50 value of ADP on platelet aggregation was significantly lower with dabigatran than with FXa inhibitors. Adenosine Diphosphate 224-227 coagulation factor X Homo sapiens 302-305 35523115-7 2022 RESULTS: Five quality control markers (ginsenoside Rg1, ginsenoside Rb1, tenuifolin, poricoic acid B, and alpha-asarone) were detected in the ADP solution. Adenosine Diphosphate 142-145 RB transcriptional corepressor 1 Mus musculus 68-71 7112508-1 1982 Using a platelet-rich plasma (PRP) preparation, platelets from subjects with familial hypercholesterolemia (FH) were found to be more reactive to the aggregating agents epinephrine, ADP and thrombin than platelets obtained from normal individuals. Adenosine Diphosphate 182-185 low density lipoprotein receptor Homo sapiens 108-110 35358642-6 2022 AMP-activated protein kinase (AMPK) modulates energy metabolism in cells and its activation occurs in response to elevated AMP and ADP levels. Adenosine Diphosphate 131-134 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-28 35358642-6 2022 AMP-activated protein kinase (AMPK) modulates energy metabolism in cells and its activation occurs in response to elevated AMP and ADP levels. Adenosine Diphosphate 131-134 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 7061429-6 1982 In a second series of experiments, only sufficient hexokinase was added to potentially stimulate respiration to 90% of the ADP State 3 rate. Adenosine Diphosphate 123-126 hexokinase Saccharomyces cerevisiae S288C 51-61 35481630-5 2022 Only dimeric Suv3, but not monomeric Suv3DeltaC, binds RNA independently of ATP or ADP, and is capable of interacting with PNPase, indicating that dimeric Suv3 assembly ensures its continuous association with RNA and PNPase during ATP hydrolysis cycles for efficient RNA degradation. Adenosine Diphosphate 83-86 Suv3 like RNA helicase Homo sapiens 13-17 34860143-6 2022 MEASUREMENTS AND MAIN RESULTS: Aeroallergen-exposure induced the extracellular release of ADP and ATP, nucleotides that activate P2Y13-R. ATP, ADP, aeroallergen (house dust mite, cockroach or Alternaria) or virus exposure induced the nuclear-to-cytoplasmic translocation and subsequent release of IL-33 and HMGB1, and this response was ablated by genetic deletion or pharmacological antagonism of P2Y13. Adenosine Diphosphate 90-93 interleukin 33 Mus musculus 297-302 7041959-10 1982 These results are explained in terms of a change in the myosin cross-bridge conformation brought about by the binding of MgADP to the active site. Adenosine Diphosphate 121-126 myosin heavy chain 14 Homo sapiens 56-62 2557345-3 1989 The arginine residue (Arg187) that is the presumed site of ADP-ribosylation of Gs alpha by cholera toxin has been changed to Ala, Glu, or Lys. Adenosine Diphosphate 59-62 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 79-87 6457046-1 1981 Interaction of myosin active center with ATP and with ADP. Adenosine Diphosphate 54-57 myosin heavy chain 14 Homo sapiens 15-21 2529252-9 1989 The results suggest that the weak ATPase activity of RuvB protein is at least partly due to end product inhibition by ADP. Adenosine Diphosphate 118-121 ATPase Escherichia coli 34-40 6457046-2 1981 The kinetics of the fluorescence enhancement and the transient release of H+ caused by the binding of ADP to the active center of myosin has been compared to that caused by myosin-ATP interaction. Adenosine Diphosphate 102-105 myosin heavy chain 14 Homo sapiens 130-136 2759092-17 1989 The latter findings are suggestive of an interruption of the citric acid cycle at the level of fumarase under conditions of high energy load (i.e. high ATP/ADP ratios). Adenosine Diphosphate 156-159 fumarate hydratase Homo sapiens 95-103 6457047-2 1981 The mechanism of interaction between ADP and the myosin active center has been studied using a transient kinetic technique. Adenosine Diphosphate 37-40 myosin heavy chain 14 Homo sapiens 49-55 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 137-142 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 54-60 2773809-5 1989 To ascertain whether the receptors clustered prior to ligand binding or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the secretion of fibrinogen. Adenosine Diphosphate 171-174 integrin subunit alpha 2b Homo sapiens 239-244 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 209-215 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 209-215 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 176-179 myosin heavy chain 14 Homo sapiens 54-60 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 176-179 myosin heavy chain 14 Homo sapiens 209-215 6457047-3 1981 The results show that the interaction of ADP with the myosin active center is a homogeneous process independent of the association state of the active centers; namely, whether ADP interacts with the monomeric myosin subfragment-1, or with the dimeric forms heavy meromyosin and myosin. Adenosine Diphosphate 176-179 myosin heavy chain 14 Homo sapiens 209-215 2630100-2 1989 The respiratory control ratio (RCR) decreased by 50% on addition of 20 microM pentagalloylglucose to highly coupled mitochondria, but the adenosine-5"-diphosphate/oxygen (ADP/O) ratio decreased only slightly. Adenosine Diphosphate 138-162 seminal vesicle secretory protein 4 Rattus norvegicus 171-176 6115422-3 1981 The structure of the hexokinase crystallized in the presence of xylose and ADP is being determined at low resolution. Adenosine Diphosphate 75-78 hexokinase Saccharomyces cerevisiae S288C 21-31 2521626-0 1989 RecA protein-promoted cleavage of LexA repressor in the presence of ADP and structural analogues of inorganic phosphate, the fluoride complexes of aluminum and beryllium. Adenosine Diphosphate 68-71 RAD51 recombinase Homo sapiens 0-4 7013830-6 1981 Binding of Mg-ADP to active centres induces site-site and therefore head-head interaction, thus intact myosin is designed to be able to function asymmetrically. Adenosine Diphosphate 11-17 myosin heavy chain 14 Homo sapiens 103-109 2521626-3 1989 These data suggest that fluoride complexes of aluminum and beryllium (called herein X) convert RecA-ADP complexes, which bind weakly to single-stranded DNA, into RecA-ADP-X complexes, which bind tightly to single-stranded DNA, the ADP-X moiety behaving as a nonhydrolyzable analogue of ATP. Adenosine Diphosphate 100-103 RAD51 recombinase Homo sapiens 95-99 2521626-3 1989 These data suggest that fluoride complexes of aluminum and beryllium (called herein X) convert RecA-ADP complexes, which bind weakly to single-stranded DNA, into RecA-ADP-X complexes, which bind tightly to single-stranded DNA, the ADP-X moiety behaving as a nonhydrolyzable analogue of ATP. Adenosine Diphosphate 100-103 RAD51 recombinase Homo sapiens 162-166 2521626-4 1989 We propose that AlF4- and BeF3- ions act as analogues of inorganic phosphate by binding to the site of the gamma-phosphate of ATP on RecA-ADP complexes, hence mimicking the single-stranded DNA-RecA-ADP-Pi transition state. Adenosine Diphosphate 138-141 RAD51 recombinase Homo sapiens 133-137 2521626-4 1989 We propose that AlF4- and BeF3- ions act as analogues of inorganic phosphate by binding to the site of the gamma-phosphate of ATP on RecA-ADP complexes, hence mimicking the single-stranded DNA-RecA-ADP-Pi transition state. Adenosine Diphosphate 138-141 RAD51 recombinase Homo sapiens 193-197 2719989-2 1989 It was found that in the octameric form of mitochondrial creatine kinase (Mr = 340 kD), only 52% of active centers bind Mg-ADP into a E-Mg-ADP-creatine complex with the dissociation constant, K(Cr)ADP, of 0.105 mM, which is close to the Km value for the enzyme (0.072 mM). Adenosine Diphosphate 120-126 creatine kinase S-type, mitochondrial Oryctolagus cuniculus 43-72 2719989-2 1989 It was found that in the octameric form of mitochondrial creatine kinase (Mr = 340 kD), only 52% of active centers bind Mg-ADP into a E-Mg-ADP-creatine complex with the dissociation constant, K(Cr)ADP, of 0.105 mM, which is close to the Km value for the enzyme (0.072 mM). Adenosine Diphosphate 123-126 creatine kinase S-type, mitochondrial Oryctolagus cuniculus 43-72 2719989-6 1989 The curves for ATSC saturation with Mg-ADP in the presence of iodacetamide for mitochondrial creatine kinase were constructed and computer analyzed. Adenosine Diphosphate 36-42 creatine kinase S-type, mitochondrial Oryctolagus cuniculus 79-108 6112054-5 1981 We report that in crude homogenates of rat kidney, gamma-glutamyltransferase activity requires the presence of a divalent cation, arsenate, and ADP. Adenosine Diphosphate 144-147 gamma-glutamyltransferase 1 Rattus norvegicus 51-76 2575830-4 1989 In mammary arteries, acetylcholine, thrombin, adenosine diphosphate, histamine and the calcium ionophore A23187 evoked endothelium-dependent relaxations blocked by hemoglobin or methylene blue, but not by cyclooxygenase inhibitors delineating EDRF as the mediator; in vascular smooth muscle cells, this was associated with a rise in intracellular cyclic GMP. Adenosine Diphosphate 46-67 5'-nucleotidase, cytosolic II Homo sapiens 354-357 7450901-5 1981 By using selective inhibitors, we show that PMN aggregation, induced either by PAF or by other soluble stimuli such as C5a, CP and their des Arg products, follows a similar metabolic pathway, which is both adenosine-diphosphate-(ADP)- and arachidonic acid (AA)- independent. Adenosine Diphosphate 206-228 PCNA clamp associated factor Homo sapiens 79-82 2844786-2 1988 Genetic and biochemical analysis of Saccharomyces cerevisiae containing a disruption of the nuclear gene (AAC1) encoding the mitochondrial ADP/ATP carrier has revealed a second gene for this protein. Adenosine Diphosphate 139-142 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 106-110 7358655-4 1980 Myosin was first treated with N-ethylmaleimide to block S1 and then treated with a fluorogenic thiol reagent, N-(7-dimethyl-amino-4-methylcoumarinyl) maleimide (DACM), in the presence or absence of ADP. Adenosine Diphosphate 198-201 myosin heavy chain 14 Homo sapiens 0-6 3177660-6 1988 Adenosine diphosphate stimulated DNA synthesis in quiescent cultures and enhanced both c-sis expression and release of PDGF-like activity. Adenosine Diphosphate 0-21 platelet derived growth factor subunit B Homo sapiens 87-92 2971972-4 1988 First, cell stimulation with ADP induces high-affinity binding of coagulation factor X to the surface-adhesive receptor Mac-1. Adenosine Diphosphate 29-32 coagulation factor X Homo sapiens 66-86 7358655-5 1980 From the distribution of DACM in the two kinds of DACM-treated myosin, it was found that thiol groups of all the light chains and of the 50 K fragment of subfragment-1 heavy chain became less reactive to DACM in the presence of ADP. Adenosine Diphosphate 228-231 myosin heavy chain 14 Homo sapiens 63-69 2971972-4 1988 First, cell stimulation with ADP induces high-affinity binding of coagulation factor X to the surface-adhesive receptor Mac-1. Adenosine Diphosphate 29-32 integrin subunit alpha M Homo sapiens 120-125 158525-0 1979 Differential binding of myosin subfragment one species to immobilized ADP, and actin: the influence of the alkali light chains. Adenosine Diphosphate 70-73 myosin heavy chain 14 Homo sapiens 24-30 2455569-9 1988 These results demonstrate that the binding of IgG molecules to the CD9 antigen exposes fibrinogen receptors through both secreted ADP and thromboxane and that either one of both can expose the receptors to an extent sufficient to aggregate platelets. Adenosine Diphosphate 130-133 CD9 molecule Homo sapiens 67-70 221484-5 1979 All three species of Fragment A are active in catalyzing ADP ribosylation of elongation factor 2, an essential component of protein synthesis. Adenosine Diphosphate 57-60 eukaryotic translation elongation factor 2 Homo sapiens 77-96 2839333-7 1988 Pertussis toxin eliminated ANF-dependent inhibition of adenylate cyclase by catalyzing ADP-ribosylation of membrane-bound Ni protein (41-kDa alpha subunit of the inhibitory guanyl-nucleotide-binding protein of adenylate cyclase). Adenosine Diphosphate 87-90 natriuretic peptide A Rattus norvegicus 27-30 2971391-8 1988 The pH profiles for the biotin carboxylase catalyzed phosphorylation of ADP by carbamoyl phosphate have the same shape as the profiles for the forward reaction, which demonstrates that the enzymic bases assume the same protonation states for catalysis of transphosphorylation in either direction. Adenosine Diphosphate 72-75 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 24-42 3283237-3 1988 Uptake of 125I-C3a by guinea pig platelets is maximal in 1 min, and stimulation of guinea pig platelets by thrombin, ADP, or the Ca2+ ionophore A23187 showed little influence on binding of the ligand. Adenosine Diphosphate 117-120 complement C3 Homo sapiens 15-18 162261-0 1979 Kinetic study of the inhibition of myosin ATPase activity by ADP. Adenosine Diphosphate 61-64 myosin heavy chain 14 Homo sapiens 35-41 3291184-8 1988 Indomethacin showed weak inhibition on the aggregation while the ADP-scavenging system, creatine phosphate/creatine phosphokinase, inhibited the aggregation induced by the three thrombin-like enzymes but not that by thrombin. Adenosine Diphosphate 65-68 prothrombin Oryctolagus cuniculus 178-186 3291184-8 1988 Indomethacin showed weak inhibition on the aggregation while the ADP-scavenging system, creatine phosphate/creatine phosphokinase, inhibited the aggregation induced by the three thrombin-like enzymes but not that by thrombin. Adenosine Diphosphate 65-68 prothrombin Oryctolagus cuniculus 216-224 3291184-13 1988 It is concluded that the aggregation induced by the thrombin-like enzymes is different from that of thrombin and mainly due to ADP released from platelets. Adenosine Diphosphate 127-130 prothrombin Oryctolagus cuniculus 52-60 3129344-0 1988 Reconstituted microsomal lipid peroxidation: ADP-Fe3+-dependent peroxidation of phospholipid vesicles containing NADPH-cytochrome P450 reductase and cytochrome P450. Adenosine Diphosphate 45-48 cytochrome p450 oxidoreductase Rattus norvegicus 113-144 152310-16 1978 About 1.3 mol of ATP per mol of myosin was hydrolyzed at both 0 degrees C and 20 degrees C during one cycle of the changes in the rate of ADP liberation. Adenosine Diphosphate 138-141 myosin heavy chain 14 Homo sapiens 32-38 641045-3 1978 Exchange probably occurs by formation of myosin.ATP from a myosin.ADP.Pi complex and is rapid relative to release of Pi from this complex. Adenosine Diphosphate 66-69 myosin heavy chain 14 Homo sapiens 41-47 2957691-3 1987 The purified RAD3 protein shows a single-stranded DNA-dependent ATPase activity that catalyzes hydrolysis of ATP to ADP and Pi. Adenosine Diphosphate 116-119 TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 Saccharomyces cerevisiae S288C 13-17 2956659-4 1987 All these Ki values were much smaller than those of ADP which is also a competitive inhibitor for the ATPase activity of the recA protein. Adenosine Diphosphate 52-55 RAD51 recombinase Homo sapiens 125-129 641045-3 1978 Exchange probably occurs by formation of myosin.ATP from a myosin.ADP.Pi complex and is rapid relative to release of Pi from this complex. Adenosine Diphosphate 66-69 myosin heavy chain 14 Homo sapiens 59-65 641045-4 1978 The kinetics of exchange give a value for the rate constant for binding Pi to myosin.ADP of 0.23 M-1 S-1 (pH 8.0, 22 degrees C). Adenosine Diphosphate 85-88 myosin heavy chain 14 Homo sapiens 78-84 2884218-5 1987 The inactivation of ATPase activity by 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (Nbd-Cl, an adenine analog) was protected by MgATP or MgADP, and showed kinetic properties consistent with active site-directed inhibition. Adenosine Diphosphate 133-138 ATPase Escherichia coli 20-26 3035738-2 1987 In parallel, PDE inhibitors inhibit the increase in cytoplasmic free Ca2+ evoked by ADP, as measured with the fluorescent probe quin 2. Adenosine Diphosphate 84-87 aldehyde dehydrogenase 7 family member A1 Homo sapiens 13-16 3641060-3 1986 Recently we have identified Trp 130 of the myosin heavy chain from rabbit skeletal muscle as an active-site amino-acid residue after labelling with a new photoaffinity analogue of ADP, N-(4-azido-2-nitrophenyl)-2-aminoethyl diphosphate (NANDP). Adenosine Diphosphate 180-183 PBV1SPCR2 Oryctolagus cuniculus 43-61 339944-6 1978 As its nonessential thiol 3 groups are rendered the most reactive of all thiol groups in the enzyme-product complex M**ADP.Pi, the hydrolytic step induces an allosteric conformational change in the neck region of intact myosin. Adenosine Diphosphate 119-122 myosin heavy chain 14 Homo sapiens 220-226 233787-2 1978 Glucokinase was absent from chicken liver and only the low Km hexokinases, inhibited by AMP, ADP but not ATP, were present. Adenosine Diphosphate 93-96 glucokinase Gallus gallus 0-11 196649-0 1977 The mechanism of ADP-ribosylation of elongation factor 2 catalyzed by fragment A from diphtheria toxin. Adenosine Diphosphate 17-20 eukaryotic translation elongation factor 2 Homo sapiens 37-56 138677-8 1976 The amount of ADP bound to myofibrils during the ATPase reaction and the ATPase activity were measured by coupling the myofibrillar ATPase reaction with sufficient amounts of pyruvate kinase [EC 2.7.1.40] and PEP to regenerate ATP. Adenosine Diphosphate 14-17 progestagen associated endometrial protein Homo sapiens 209-212 138677-9 1976 The maximum amount of ADP bound to myofibrils in 0.05M KCl and in the relaxed state was about 1.5 mole/mole of myosin. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 111-117 138677-12 1976 The maximum amount of ADP bound to myofibrils in 0.5 M KCl was about 1.9 mole/mole of myosin. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 86-92 138677-13 1976 When about one mole of ADP was found to 1 mole of myosin in myofibrils, the myofibrillar ATPase activity reached the saturated level, and with further increase in the concentration of ATP one more mole of ADP was found per mole of myosin. Adenosine Diphosphate 23-26 myosin heavy chain 14 Homo sapiens 50-56 138677-13 1976 When about one mole of ADP was found to 1 mole of myosin in myofibrils, the myofibrillar ATPase activity reached the saturated level, and with further increase in the concentration of ATP one more mole of ADP was found per mole of myosin. Adenosine Diphosphate 23-26 myosin heavy chain 14 Homo sapiens 231-237 138677-13 1976 When about one mole of ADP was found to 1 mole of myosin in myofibrils, the myofibrillar ATPase activity reached the saturated level, and with further increase in the concentration of ATP one more mole of ADP was found per mole of myosin. Adenosine Diphosphate 205-208 myosin heavy chain 14 Homo sapiens 50-56 138677-13 1976 When about one mole of ADP was found to 1 mole of myosin in myofibrils, the myofibrillar ATPase activity reached the saturated level, and with further increase in the concentration of ATP one more mole of ADP was found per mole of myosin. Adenosine Diphosphate 205-208 myosin heavy chain 14 Homo sapiens 231-237 124270-5 1975 Measurements of the reversal of ATP cleavage and binding by myosin suggest that oxygen exchanges result from reversible cleavage of ATP to ADP and Pi at the catalytic site and that the principal free energy change in ATP cleavage occurs in ATP binding. Adenosine Diphosphate 139-142 myosin heavy chain 14 Homo sapiens 60-66 3087006-3 1986 Collagen and arachidonic acid (AA) induced aggregation in heparin-PRP only, and ADP induced greater aggregation in heparin-PRP than in citrate-PRP. Adenosine Diphosphate 80-83 proline rich protein 2-like 1 Rattus norvegicus 123-126 124949-2 1975 The interaction of purified actin and myosin from human muscle, in the presence of Mg-2+-ATP, was stimulated by minute amounts of adenosine diphosphate (ADP), a product of ATP hydrolysis. Adenosine Diphosphate 130-151 myosin heavy chain 14 Homo sapiens 38-44 3087006-6 1986 Anesthetics affected rat platelet aggregation: the rank order of the maximal extent of ADP-induced aggregation in citrate-PRP was M greater than E = A/K greater than P, and that for AA and collagen in heparin-PRP was E = A/K greater than M = P. The correlation between the effect of the anesthetics and activation of the sympathoadrenal system is discussed. Adenosine Diphosphate 87-90 proline rich protein 2-like 1 Rattus norvegicus 122-125 3087006-6 1986 Anesthetics affected rat platelet aggregation: the rank order of the maximal extent of ADP-induced aggregation in citrate-PRP was M greater than E = A/K greater than P, and that for AA and collagen in heparin-PRP was E = A/K greater than M = P. The correlation between the effect of the anesthetics and activation of the sympathoadrenal system is discussed. Adenosine Diphosphate 87-90 proline rich protein 2-like 1 Rattus norvegicus 209-212 2869109-7 1986 The phenomenon probably arises from the production by glutamine synthetase of ADP, a known product inhibitor of ATP citrate lyase. Adenosine Diphosphate 78-81 glutamate-ammonia ligase Rattus norvegicus 54-74 124949-2 1975 The interaction of purified actin and myosin from human muscle, in the presence of Mg-2+-ATP, was stimulated by minute amounts of adenosine diphosphate (ADP), a product of ATP hydrolysis. Adenosine Diphosphate 153-156 myosin heavy chain 14 Homo sapiens 38-44 3012060-4 1986 AAP also inhibited the platelet aggregation of platelet-rich plasma (PRP) induced by collagen, Ca-ionophore A-23187, adenosine diphosphate (ADP), thrombin or arachidonic acid in vitro. Adenosine Diphosphate 117-138 proline rich protein 2-like 1 Rattus norvegicus 69-72 123763-2 1975 While below 10 degrees C, the initial burst of Pi liberation in the hydrolysis of Mn(II)-ATP by heavy meromyosin or myosin subfragment 1 was inhibited by the pre-addition of ADP without any change in the steady-state activity, it was not inhibited above 10 degrees C. The burst size was about one mole per two moles of myosin active sites. Adenosine Diphosphate 174-177 myosin heavy chain 14 Homo sapiens 106-112 3001695-0 1985 Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21. Adenosine Diphosphate 29-32 P21 Meleagris gallopavo 111-114 123763-2 1975 While below 10 degrees C, the initial burst of Pi liberation in the hydrolysis of Mn(II)-ATP by heavy meromyosin or myosin subfragment 1 was inhibited by the pre-addition of ADP without any change in the steady-state activity, it was not inhibited above 10 degrees C. The burst size was about one mole per two moles of myosin active sites. Adenosine Diphosphate 174-177 myosin heavy chain 14 Homo sapiens 116-122 3001695-11 1985 Like the G proteins and transducin, activity of p21 was altered by ADP-ribosylation. Adenosine Diphosphate 67-70 P21 Meleagris gallopavo 48-51 123763-7 1975 These two results indicate that in Mn-ATP above 10 degrees C at the burst site there is a myosin*-ADP-Pi complex generated by ATP hydrolysis while below 10 degrees C there is a myosin-product complex identical with the one generated by adding ADP (and Pi) to myosin. Adenosine Diphosphate 98-101 myosin heavy chain 14 Homo sapiens 90-96 173927-2 1975 The following results were obtained with the addition of ATP (during various conditions of hydrolysis), ADP, and pyrophosphate: (1) no changes were observed in the far UV CD, (2) ATP and ADP perturbed the near UV CD only at spectral regions below 280 nm coinciding with the regions of their optical activity, (3) the optically inactive pyrophosphate caused no change in the near UV CD, and (4) myosin and HMM gave exactly the same results. Adenosine Diphosphate 187-190 myosin heavy chain 14 Homo sapiens 394-400 3900066-2 1985 ADP was an activator of CDP reduction; ADP reduction was activated by dGDP; GDP reduction was activated by dTDP. Adenosine Diphosphate 0-3 TAR DNA-binding protein-43 homolog Drosophila melanogaster 107-111 2982440-8 1985 Thus, not only agents such as thrombin and plasmin that cause the release of the contents of the platelet granules decrease platelet density, but ADP also has this effect. Adenosine Diphosphate 146-149 prothrombin Oryctolagus cuniculus 30-38 3992525-1 1985 PAF-acether (platelet-activating factor) was hypothesized as the mediator of the ADP and thromboxane-independent activation of platelets induced by thrombin (Thr) and by the snake venom glycoprotein convulxin (Cx). Adenosine Diphosphate 81-84 prothrombin Oryctolagus cuniculus 148-156 2997065-2 1985 Kadsurenone inhibits the specific binding of 3H-PAF to a receptor preparation from rabbit platelet membrane in a competitive and reversible manner, its Ki being 3.88 X 10(-8) M. It inhibits the aggregation of rabbit platelets in plasma induced by PAF with a pA2 of 6.28, but not those induced by arachidonic acid, epinephrine, ADP or A-23187. Adenosine Diphosphate 327-330 PCNA clamp associated factor Rattus norvegicus 48-51 2997067-3 1985 The addition of the aggregating substance (ADP, collagen) to PRP but not to PPP was followed by PMN activation as shown by enzyme release and O-2 generation. Adenosine Diphosphate 43-46 immunoglobulin kappa variable 1D-39 Homo sapiens 142-145 4281653-1 1974 Evidence is presented that the myosin subfragment-1-ADP complex, generated by the addition of Mg(2+) and ADP to subfragment 1, is an intermediate within the myosin Mg(2+)-dependent adenosine triphosphatase (ATPase) turnover cycle. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 31-37 6496965-4 1984 GA3PDH was inhibited by ATP (Ki = 2.27 mM), ADP (Ki = 1.21 mM) and AMP (Ki = 0.73 mM) competitively with NAD (Km = 0.24 mM). Adenosine Diphosphate 44-47 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 0-6 6237610-3 1984 The inhibitions by these analogs were much stronger than that by ADP, which is also a competitive inhibitor for the ATPase activity of the recA protein. Adenosine Diphosphate 65-68 RAD51 recombinase Homo sapiens 139-143 4281653-1 1974 Evidence is presented that the myosin subfragment-1-ADP complex, generated by the addition of Mg(2+) and ADP to subfragment 1, is an intermediate within the myosin Mg(2+)-dependent adenosine triphosphatase (ATPase) turnover cycle. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 157-163 4980593-0 1969 Equilibrium binding of adenosine diphosphate to myosin. Adenosine Diphosphate 23-44 myosin heavy chain 14 Homo sapiens 48-54 6326756-1 1984 Experiments with washed platelets from rabbits demonstrate that stimulation with a low concentration of thrombin (0.1 unit/ml) that causes maximal aggregation and partial release of granule contents does not significantly decrease the amount of phosphatidylinositol 4,5-bisphosphate [ PtdIns (4,5)P2] at 10s; this contrasts with ADP stimulation. Adenosine Diphosphate 329-332 prothrombin Oryctolagus cuniculus 104-112 6721848-7 1984 It is suggested that the stimulation of pyruvate carboxylase is a result of a general activation of mitochondrial function, with an increase in the intramitochondrial concentrations of acetyl-CoA and ATP, a decrease in glutamate and an enhanced intramitochondrial [ATP]/[ADP] ratio. Adenosine Diphosphate 271-274 pyruvate carboxylase Rattus norvegicus 40-60 4223370-2 1966 Liberation of ADP from the myosin--ATP system and effects of modifiers on the phosphorylation of myosin. Adenosine Diphosphate 14-17 myosin heavy chain 14 Homo sapiens 27-33 13881477-0 1962 Modifications of myosin caused by adenosinetriphosphate, adenosinediphosphate and pyrophosphate. Adenosine Diphosphate 57-77 myosin heavy chain 14 Homo sapiens 17-23 6698994-11 1984 Both for inactivation of HMG-CoA reductase and for phosphorylation of bovine serum albumin protein, the ability of nucleoside diphosphates to replace ADP decreased in the order ADP greater than CDP, dADP greater than UDP. Adenosine Diphosphate 150-153 albumin Rattus norvegicus 77-90 6698994-11 1984 Both for inactivation of HMG-CoA reductase and for phosphorylation of bovine serum albumin protein, the ability of nucleoside diphosphates to replace ADP decreased in the order ADP greater than CDP, dADP greater than UDP. Adenosine Diphosphate 177-180 albumin Rattus norvegicus 77-90 6696911-3 1984 3 S. The specificity of the interaction of this androgen receptor with nucleotides was investigated in a competitive binding assay using inhibition of binding of the steroid receptor complex to ADP-Sepharose. Adenosine Diphosphate 194-197 androgen receptor Rattus norvegicus 48-65 33887230-6 2021 ANT flux control coefficients were 0.91 +- 0.07, 0.83 +- 0.06, and 0.51 +- 0.07 at ADP concentrations of 6.25, 12.5, and 25 muM, respectively, an [ADP] range which spanned the K0.5ADP. Adenosine Diphosphate 83-86 solute carrier family 25 member 6 Homo sapiens 0-3 6318184-4 1983 Inhibition of specific [3H]cAMP binding to lung cytosol (to the regulatory subunit of the cAMP-dependent protein kinase) followed the order of potency: cAMP greater than cGMP; adenosine, ADP, and ATP were inactive. Adenosine Diphosphate 187-190 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 105-119 6226659-6 1983 AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid. Adenosine Diphosphate 14-17 transcription factor AP-2 alpha Homo sapiens 0-4 6226659-6 1983 AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid. Adenosine Diphosphate 14-17 transcription factor AP-2 alpha Homo sapiens 162-166 6226659-6 1983 AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid. Adenosine Diphosphate 275-296 transcription factor AP-2 alpha Homo sapiens 0-4 33887230-6 2021 ANT flux control coefficients were 0.91 +- 0.07, 0.83 +- 0.06, and 0.51 +- 0.07 at ADP concentrations of 6.25, 12.5, and 25 muM, respectively, an [ADP] range which spanned the K0.5ADP. Adenosine Diphosphate 147-150 solute carrier family 25 member 6 Homo sapiens 0-3 6226659-6 1983 AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid. Adenosine Diphosphate 275-296 transcription factor AP-2 alpha Homo sapiens 162-166 33722515-1 2021 In post-mitotic cells, mitochondrial ATP/ADP exchange occurs by the adenine nucleotide translocator (ANT). Adenosine Diphosphate 41-44 solute carrier family 25 member 6 Homo sapiens 68-99 6617661-0 1983 Inhibition of ADP-induced platelet aggregation by reduced factor Xa. Adenosine Diphosphate 14-17 coagulation factor X Homo sapiens 58-67 6617661-2 1983 The reduced factor Xa was found to be a potent inhibitor of platelet aggregation and thromboxane A2 synthesis induced by ADP. Adenosine Diphosphate 121-124 coagulation factor X Homo sapiens 12-21 33722515-1 2021 In post-mitotic cells, mitochondrial ATP/ADP exchange occurs by the adenine nucleotide translocator (ANT). Adenosine Diphosphate 41-44 solute carrier family 25 member 6 Homo sapiens 101-104 6851939-0 1983 In vitro stabilization of the unoccupied glucocorticoid receptor by adenosine 5"-diphosphate. Adenosine Diphosphate 68-92 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 41-64 6851939-2 1983 Dose-response curves and kinetic studies show that ADP is as effective as ATP in stabilizing the unoccupied glucocorticoid receptor against heat inactivation. Adenosine Diphosphate 51-54 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 108-131 6851939-4 1983 The addition of creatine phosphate plus creatine kinase, a condition favoring ATP formation, stimulates the rate of inactivation of the unoccupied glucocorticoid receptor, and the effect is only partially overcome by ADP. Adenosine Diphosphate 217-220 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 147-170 6859536-2 1983 In the assay, production of ATP from carbamoyl phosphate and ADP by carbamate kinase is coupled to the formation of NADPH, using glucose, hexokinase, NADP+, and glucose-6-phosphate dehydrogenase. Adenosine Diphosphate 61-64 glucose-6-phosphate dehydrogenase Homo sapiens 161-194 6215942-3 1982 Furthermore, preincubation of F1 with unlabeled AdoPP[NH]P, ADP, or ATP prevented the covalent labeling of the enzyme by [3H]NAP4-AdoPP[NH]P upon photoirradiation. Adenosine Diphosphate 60-63 suppressor of cytokine signaling 7 Homo sapiens 125-129 33722515-2 2021 Driven by membrane potential (DeltaPsi), ANT catalyzes electrogenic exchange of ATP4- for ADP3-, leading to higher ATP/ADP ratios in the cytosol than mitochondria. Adenosine Diphosphate 90-93 solute carrier family 25 member 6 Homo sapiens 41-44 7340442-5 1981 ADP-induced platelet aggregation (PA) in rat PRP but, at high concentrations, inhibited PA (IC50 = 390 mumol/l). Adenosine Diphosphate 0-3 proline rich protein 2-like 1 Rattus norvegicus 45-48 33722515-3 2021 In cancer cells, ATP/ADP exchange occurs not by ANT but likely via the non-electrogenic ATP-Mg/phosphate carrier. Adenosine Diphosphate 21-24 solute carrier family 25 member 6 Homo sapiens 48-51 34029503-12 2022 P-selectin expression correlated with RP percentage and platelet size indexes when platelets were activated by 10 microM TRAP inducing maximum expression of this activation marker (r from 0.332 to 0.556, p from 0.008 to < 0.001, n = 65), but not by weaker agonists: 1 microM TRAP, 20 and 2.5 microM ADP (r < 0.3, n = 54-66). Adenosine Diphosphate 299-302 selectin P Homo sapiens 0-10 6458284-1 1981 Ecto-ATPase in rat cauda-epididymal intact spermatozoa has a high degree of substrate specificity for the hydrolysis of ATP and dATP rather than of ADP, AMP, GTP, dGTP, CTP, dCTP, TTP and UTP. Adenosine Diphosphate 148-151 CEA cell adhesion molecule 1 Rattus norvegicus 0-11 33332716-5 2021 Furthermore, under 1- and 5-Hz pacing, ZFHX3 KD cells showed higher IKATP , ATP and ADP production, mitochondrial oxidative stress, and Ca2+ content than control cells. Adenosine Diphosphate 84-87 zinc finger homeobox 3 Homo sapiens 39-44 6940159-1 1981 5-Oxo-L-prolinase, the enzyme that catalyzes the conversion of 5-oxo-L-proline to L-glutamate coupled to the cleavage of ATP to ADP and Pi, also acts on L-2-oxothiazolidine-4-carboxylate (an analog of 5-oxoproline in which the 4-methylene moiety is replaced by sulfur) and ATP to yield cysteine and ADP. Adenosine Diphosphate 128-131 5-oxoprolinase (ATP-hydrolysing) Mus musculus 0-17 6940159-1 1981 5-Oxo-L-prolinase, the enzyme that catalyzes the conversion of 5-oxo-L-proline to L-glutamate coupled to the cleavage of ATP to ADP and Pi, also acts on L-2-oxothiazolidine-4-carboxylate (an analog of 5-oxoproline in which the 4-methylene moiety is replaced by sulfur) and ATP to yield cysteine and ADP. Adenosine Diphosphate 299-302 5-oxoprolinase (ATP-hydrolysing) Mus musculus 0-17 7413850-2 1980 However, preincubation of platelet rich plasma (PRP) prepared in sodium citrate with AA (1 mM) enhanced the aggregation induced by collagen suspension or adenosine diphosphate (ADP), and this enhancement was abolished by the preincubation of PRP with indomethacin. Adenosine Diphosphate 154-175 proline rich protein 2-like 1 Rattus norvegicus 48-51 7413850-2 1980 However, preincubation of platelet rich plasma (PRP) prepared in sodium citrate with AA (1 mM) enhanced the aggregation induced by collagen suspension or adenosine diphosphate (ADP), and this enhancement was abolished by the preincubation of PRP with indomethacin. Adenosine Diphosphate 177-180 proline rich protein 2-like 1 Rattus norvegicus 48-51 7413850-5 1980 Preincubation of citrated PRP with imidazole neither abolished the enhancement of ADP-induced or collagen-induced aggregation by AA (1mM), nor attenuated the aggregation induced by ADP or collagen alone; but imidazole inhibited the synthesis of TXB2 by more than 90%. Adenosine Diphosphate 82-85 proline rich protein 2-like 1 Rattus norvegicus 26-29 7413850-5 1980 Preincubation of citrated PRP with imidazole neither abolished the enhancement of ADP-induced or collagen-induced aggregation by AA (1mM), nor attenuated the aggregation induced by ADP or collagen alone; but imidazole inhibited the synthesis of TXB2 by more than 90%. Adenosine Diphosphate 181-184 proline rich protein 2-like 1 Rattus norvegicus 26-29 6264330-7 1980 (2) Adenosine deaminase blocked the responses to AMP, ADP, ATP, and adenosine-containing coenzymes. Adenosine Diphosphate 54-57 adenosine deaminase Homo sapiens 4-23 551286-6 1979 In view of these observations, a report that unphysiologically large (5--15 mg ml(-1)) amounts of AAG inhibit the platelet aggregation induced by ADP and adrenaline, and evidence that a sialic acid-deficient species of AAG appears elevated in several chronic disease states, we compared the effects of AAG and its desialised counterpart (AAG-D) on platelet aggregation. Adenosine Diphosphate 146-149 N-methylpurine DNA glycosylase Homo sapiens 98-101 551286-7 1979 We report that desialisation of AAG is associated with increased expression of activity inhibitory to the platelet aggregation otherwise observed on stimulation with ADP, collagen or thrombin. Adenosine Diphosphate 166-169 N-methylpurine DNA glycosylase Homo sapiens 32-35 444561-3 1979 The sulfated proteoglycan contained in the granules of platelets pretreated with ADP was subsequently released by treatment with thrombin. Adenosine Diphosphate 81-84 prothrombin Oryctolagus cuniculus 129-137 215226-5 1978 However, incubation of platelet-rich plasma with both cyclic GMP and cyclic AMP results in a partial recovery of the platelet responsiveness towards ADP-induced aggregation. Adenosine Diphosphate 149-152 5'-nucleotidase, cytosolic II Homo sapiens 61-64 729572-3 1978 Most (ADP-ribose)n-histone H1 conjugates formed in vivo carried single ADP-ribose units, less than one fourth of the total ADP-ribose residues being in the form of oligomeric or polymeric chains. Adenosine Diphosphate 6-9 H1.0 linker histone Homo sapiens 19-29 729572-3 1978 Most (ADP-ribose)n-histone H1 conjugates formed in vivo carried single ADP-ribose units, less than one fourth of the total ADP-ribose residues being in the form of oligomeric or polymeric chains. Adenosine Diphosphate 71-74 H1.0 linker histone Homo sapiens 19-29 729572-7 1978 By contrast, isolated HeLa nuclei formed ADP-ribosylated histone H1 which contained predominantly polymeric ADP-ribose residues. Adenosine Diphosphate 41-44 H1.0 linker histone Homo sapiens 57-67 729572-9 1978 A comparison with the ADP-ribosylated non-histone proteins indicated that histone H1 formed in vivo carried less than 2.5% of the total protein-bound ADP-ribose residues and less than 1% of the protein-bound ADP-ribose synthesized in vitro. Adenosine Diphosphate 22-25 H1.0 linker histone Homo sapiens 74-84 659964-1 1978 HAL, a congener of clofibrate, has previously been shown to inhibit epinephrine- and ADP-induced platelet aggregation and 14C-serotonin release. Adenosine Diphosphate 85-88 histidine ammonia-lyase Homo sapiens 0-3 191063-10 1977 Upon addition of atractyloside or of other specific ligands, spin-labeled long-chain acyl-ATRs bound to the ADP carrier are displaced from their binding site toward the lipid phase of the mitochondrial membrane and the short chain (0,2)acyl-ATR is released into the aqueous phase. Adenosine Diphosphate 108-111 spindlin 1 Homo sapiens 61-65 191063-11 1977 Spin-labeled long-chain acyl-ATRs do not show any evidence of binding to a protein when incubated with "inside out" submitochondrial particles, in spite of the fact that these particles are able to transport ADP. Adenosine Diphosphate 208-211 spindlin 1 Homo sapiens 0-4 974086-3 1976 Application of a strong radio-frequency field H2 at a frequency of 0.9 ppm or 1.7 ppm downfield from the proton resonance of 2,2-dimethyl-2-silapentane-5-sulfonate results in a negative NOE for the H2-2 proton resonance of ADP in its complex with creatine kinase. Adenosine Diphosphate 223-226 relaxin 2 Homo sapiens 198-202 974086-6 1976 The large negative NOE for the H-2 proton of ADP is maintained for the various binary, ternary, quaternary, and pentenary complexes of creatine kinase with ADP formed by addition of the activator Mg(II), the other substrate creatine, and the planar anion nitrate which is an inhibitor. Adenosine Diphosphate 45-48 relaxin 2 Homo sapiens 31-34 974086-6 1976 The large negative NOE for the H-2 proton of ADP is maintained for the various binary, ternary, quaternary, and pentenary complexes of creatine kinase with ADP formed by addition of the activator Mg(II), the other substrate creatine, and the planar anion nitrate which is an inhibitor. Adenosine Diphosphate 156-159 relaxin 2 Homo sapiens 31-34 974086-10 1976 However, as indicated by the large negative NOE for the H-2 proton of ADP in a binary complex with the inactivated enzyme, the environment around the base is altered minimally. Adenosine Diphosphate 70-73 relaxin 2 Homo sapiens 56-59 974086-13 1976 The H-2 proton of 1-N6-ethenoadenosine 5"-diphosphate, an analogue of ADP with the 1-nitrogen and 6-nitrogen blocked from potentially hydrogen bonding, still exhibits a large NOE in the nucleotide-enzyme complex. Adenosine Diphosphate 70-73 relaxin 2 Homo sapiens 4-7 974086-14 1976 The indication is that the protons promoting the H-2 proton NOE are not on an amino acid residue which binds ADP by hydrogen binding. Adenosine Diphosphate 109-112 relaxin 2 Homo sapiens 49-52 175045-4 1975 ADP also inhibited cytochrome b5 reduction with alpha-NADH. Adenosine Diphosphate 0-3 cytochrome b5 type A Rattus norvegicus 19-32 1188320-2 1975 ADP-induced aggregation was determined at various times of incubation with ADP in unstirred human platelet rich plasma (PRP) to which adenosine deaminase was added. Adenosine Diphosphate 0-3 adenosine deaminase Homo sapiens 134-153 5472154-2 1970 A radiochemical assay for glutamine synthetase has been developed in which an ATP-regenerating system is incorporated to prevent accumulation of inhibitory amounts of ADP. Adenosine Diphosphate 167-170 glutamate-ammonia ligase Rattus norvegicus 26-46 34043989-5 2021 An increase in AMP:ATP and ADP:ATP ratio leads to activation of AMPK signaling by upstream mediators such as LKB1 and CamKK. Adenosine Diphosphate 27-30 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 64-68 33932586-10 2021 Furthermore, MICU2 silencing in INS1 832/13 cells, presumably through its effects on mitochondrial Ca2+ uptake, perturbed mitochondrial function illustrated by absent mitochondrial membrane hyperpolarization and lowering of the ATP/ADP ratio in response to an elevation of glucose. Adenosine Diphosphate 232-235 mitochondrial calcium uptake 2 Rattus norvegicus 13-18 33289262-3 2021 The chirality induction in CD (g abs -10 -4 ) and CPL (g lum -10 -4 ) of P - SOF-1 from achiral SOF-1 can be presented using a small amount of adenosine-5"-triphosphate disodium (ATP) or adenosine-5"-diphosphate disodium (ADP) (only 0.4 equiv) in water. Adenosine Diphosphate 226-229 hephaestin Homo sapiens 52-105 33626581-11 2021 Levels of integrin alphaIIbbeta3 activation, fibrinogen binding, and aggregation were significantly lower in platelets from RUNX1L43S/L43S and RUNX1WT/L43S using phorbol 12-myristate 13-acetate (PMA), adenosine diphosphate (ADP), and high thrombin doses. Adenosine Diphosphate 224-227 runt related transcription factor 1 Mus musculus 124-129 33552071-9 2020 Finally, we show that SIRPalpha suppression is mediated via the phosphatase, Shp1, which in turn suppresses SYK-dependent activation of ADP. Adenosine Diphosphate 136-139 spleen associated tyrosine kinase Homo sapiens 108-111 33552071-11 2020 This is the first study to show that activation of the CD47:SIRPalpha innate immune checkpoint contributes to ADP resistance in NLCs from CLL patients. Adenosine Diphosphate 110-113 CD47 molecule Homo sapiens 55-59 31992110-8 2021 When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP. Adenosine Diphosphate 20-23 TRAP Homo sapiens 201-205 33284729-4 2022 Platelets from untreated blood samples and samples treated with either adenosine diphosphate (ADP) or thrombin receptor agonist peptide (TRAP) had surface GPIbalpha, activated GPIIb-IIIa, and P-selectin levels measured using flow cytometry. Adenosine Diphosphate 94-97 glycoprotein Ib platelet subunit alpha Homo sapiens 155-164 32356316-2 2020 We show that MA inhibited the enzymatic activity of FXa and platelet aggregation, induced by adenosine diphosphate (ADP) and a thromboxane A2 (TXA2 ) analog, U46619 with a similar antithrombotic efficacy to rivaroxaban, a direct FXa inhibitor used as a positive control. Adenosine Diphosphate 116-119 coagulation factor X Homo sapiens 52-55 33262195-1 2020 BACKGROUND: It was recently reported that highly elevated plasma activity of the ADP-scavenging enzyme creatine kinase (CK), to >10 times the upper reference limit (URL), is independently associated with fatal or non-fatal bleeding during treatment for ST-segment elevation myocardial infarction (OR 2.6 (95% CI, 1.8 to 2.7)/log CK increase). Adenosine Diphosphate 81-84 cytidine/uridine monophosphate kinase 1 Homo sapiens 2-4 33262195-1 2020 BACKGROUND: It was recently reported that highly elevated plasma activity of the ADP-scavenging enzyme creatine kinase (CK), to >10 times the upper reference limit (URL), is independently associated with fatal or non-fatal bleeding during treatment for ST-segment elevation myocardial infarction (OR 2.6 (95% CI, 1.8 to 2.7)/log CK increase). Adenosine Diphosphate 81-84 cytidine/uridine monophosphate kinase 1 Homo sapiens 120-122 33262195-2 2020 Evidence indicates that CK attenuates ADP-dependent platelet aggregation. Adenosine Diphosphate 38-41 cytidine/uridine monophosphate kinase 1 Homo sapiens 24-26 32747443-7 2020 Here we show during both non-ADP and low-ADP stimulated respiration that accelerating flux through beta-oxidation generates a corresponding increase in mitochondrial JH2O2 production, that the majority (~70-80%) of H2O2 produced is reduced to H2O by electrons drawn from redox buffering circuits supplied by NADPH, and that the rate of electron flux through redox buffering circuits is directly linked to changes in oxygen consumption mediated by NNT. Adenosine Diphosphate 41-44 2,4-dienoyl-CoA reductase 1 Homo sapiens 308-313 33006575-2 2020 MacroD2 is a single-domain protein that contains a deep ADP-ribose-binding groove. Adenosine Diphosphate 56-59 mono-ADP ribosylhydrolase 2 Homo sapiens 0-7 32822587-1 2020 Although ADP-ribosylation of histones by PARP-1 has been linked to genotoxic stress responses, its role in physiological processes and gene expression has remained elusive. Adenosine Diphosphate 9-12 poly (ADP-ribose) polymerase family, member 1 Mus musculus 41-47 32822587-2 2020 We found that NAD+-dependent ADP-ribosylation of histone H2B-Glu35 by small nucleolar RNA (snoRNA)-activated PARP-1 inhibits AMP kinase-mediated phosphorylation of adjacent H2B-Ser36, which is required for the proadipogenic gene expression program. Adenosine Diphosphate 29-32 poly (ADP-ribose) polymerase family, member 1 Mus musculus 109-115 33828561-8 2021 ADP accelerated cutaneous wound healing, improved new tissue formation, and increased both collagen deposition and transforming growth factor-beta (TGF-beta) production in the wound. Adenosine Diphosphate 0-3 transforming growth factor alpha Mus musculus 148-156 33828561-10 2021 Furthermore, P2Y1 receptor antagonist also blocked ADP-induced wound closure until day 7, suggesting its involvement early in repair process. Adenosine Diphosphate 51-54 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 13-26 33828561-11 2021 Interestingly, ADP treatment increased the expression of P2Y12 and P2Y1 receptors in the wound. Adenosine Diphosphate 15-18 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 57-62 33828561-11 2021 Interestingly, ADP treatment increased the expression of P2Y12 and P2Y1 receptors in the wound. Adenosine Diphosphate 15-18 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 57-61 33374308-1 2020 The actomyosin system generates mechanical work with the execution of the power stroke, an ATP-driven, two-step rotational swing of the myosin-neck that occurs post ATP hydrolysis during the transition from weakly to strongly actin-bound myosin states concomitant with Pi release and prior to ADP dissociation. Adenosine Diphosphate 293-296 myosin heavy chain 14 Homo sapiens 8-14 32857889-2 2020 Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis. Adenosine Diphosphate 98-101 melanotransferrin Homo sapiens 94-97 32857889-3 2020 The NTDs in a series of p97 disease mutants interconvert rapidly between up and down conformations when p97 is in the ADP-bound state. Adenosine Diphosphate 118-121 melanotransferrin Homo sapiens 24-27 32857889-3 2020 The NTDs in a series of p97 disease mutants interconvert rapidly between up and down conformations when p97 is in the ADP-bound state. Adenosine Diphosphate 118-121 melanotransferrin Homo sapiens 104-107 33324653-10 2020 Taken together, these data establish the presence of a new type of DNA-modifying activity in Arabidopsis PARPs, suggesting a possible role of DNA ADP-ribosylation in DNA damage signaling and repair of terrestrial plants. Adenosine Diphosphate 146-149 poly(ADP-ribose) polymerase 2 Arabidopsis thaliana 105-110 33255391-0 2020 ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors. Adenosine Diphosphate 0-3 selectin P Homo sapiens 43-48 33255391-0 2020 ADP-Mediated Upregulation of Expression of CD62P on Human Platelets Is Critically Dependent on Co-Activation of P2Y1 and P2Y12 Receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 112-116 33255391-1 2020 This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5"-diphosphate (ADP, 100 micromol L-1) Platelet-rich plasma (PRP) was prepared from the blood of adult humans. Adenosine Diphosphate 207-210 purinergic receptor P2Y1 Homo sapiens 50-54 33255391-1 2020 This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5"-diphosphate (ADP, 100 micromol L-1) Platelet-rich plasma (PRP) was prepared from the blood of adult humans. Adenosine Diphosphate 207-210 selectin P Homo sapiens 89-94 33255391-1 2020 This study probed the differential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 5"-diphosphate (ADP, 100 micromol L-1) Platelet-rich plasma (PRP) was prepared from the blood of adult humans. Adenosine Diphosphate 207-210 selectin P Homo sapiens 96-106 33255391-2 2020 CD62P was measured by flow cytometry following activation of PRP with ADP in the absence and presence of the selective antagonists of P2Y1 and P2Y12 receptors, MRS2500 and PSB0739 (both 0.155-10 micromol L-1), respectively. Adenosine Diphosphate 70-73 selectin P Homo sapiens 0-5 33155794-6 2020 Our data demonstrate that YME1L-AAA+ binds ATP and ADP with affinities equal to ~30 and 5 muM, respectively, in the absence of Mg2+. Adenosine Diphosphate 51-54 YME1 like 1 ATPase Homo sapiens 26-31 32253421-6 2020 Assessed ex vivo, maximal ADP-stimulated respiration (state 3CI+CII, PRE: 23+-6 and POST: 14+-5 rhoM mg-1 s-1, P<0.05), was decreased by MST, predominantly, as a result of a decline in complex I linked respiration (P<0.05). Adenosine Diphosphate 26-29 ras homolog family member D Homo sapiens 96-100 32518369-4 2020 Consequently, extracellular ADP activated the NLRP3 inflammasome through P2Y1 receptor-mediated calcium signaling, which led to the maturation and secretion of IL-1beta and further aggravation of experimental colitis. Adenosine Diphosphate 28-31 purinergic receptor P2Y1 Homo sapiens 73-86 32518369-4 2020 Consequently, extracellular ADP activated the NLRP3 inflammasome through P2Y1 receptor-mediated calcium signaling, which led to the maturation and secretion of IL-1beta and further aggravation of experimental colitis. Adenosine Diphosphate 28-31 interleukin 1 alpha Homo sapiens 160-168 32744313-9 2020 When only ADP was available, Ak1 disruption largely compromised sperm motility, manifested as a smaller beating amplitude and higher beating frequency, which resulted in less effective forward swimming. Adenosine Diphosphate 10-13 adenylate kinase 1 Mus musculus 29-32 33028677-6 2020 NMR and electron cryomicroscopy data have been used as restraints in molecular dynamics trajectories to develop structural ensembles for p47-p97 complexes in adenosine diphosphate (ADP)- and adenosine triphosphate (ATP)-bound conformations, highlighting differences in interactions in the two states. Adenosine Diphosphate 181-184 pleckstrin Homo sapiens 137-140 33049993-0 2020 Structural and Computational Insights into a Blebbistatin-Bound Myosin ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke. Adenosine Diphosphate 71-74 myosin heavy chain 14 Homo sapiens 64-70 33049993-0 2020 Structural and Computational Insights into a Blebbistatin-Bound Myosin ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke. Adenosine Diphosphate 71-74 myosin heavy chain 14 Homo sapiens 154-160 33049993-0 2020 Structural and Computational Insights into a Blebbistatin-Bound Myosin ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke. Adenosine Diphosphate 110-113 myosin heavy chain 14 Homo sapiens 64-70 33049993-0 2020 Structural and Computational Insights into a Blebbistatin-Bound Myosin ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke. Adenosine Diphosphate 110-113 myosin heavy chain 14 Homo sapiens 154-160 33049993-7 2020 The crystallized myosin structure thus resembles a conformation towards the end of the two-step power stroke, associated with ADP release. Adenosine Diphosphate 126-129 myosin heavy chain 14 Homo sapiens 17-23 33049993-8 2020 Computationally reconstructing ADP release from myosin by means of molecular dynamics simulations further supported the existence of an equivalent conformation along the power stroke that shows the same major characteristics in the myosin motor domain as the resolved blebbistatin-bound myosin-II ADP crystal structure, and identified a communication hub centered on Arg232 that mediates chemomechanical energy transduction. Adenosine Diphosphate 31-34 myosin heavy chain 14 Homo sapiens 48-54 33049993-8 2020 Computationally reconstructing ADP release from myosin by means of molecular dynamics simulations further supported the existence of an equivalent conformation along the power stroke that shows the same major characteristics in the myosin motor domain as the resolved blebbistatin-bound myosin-II ADP crystal structure, and identified a communication hub centered on Arg232 that mediates chemomechanical energy transduction. Adenosine Diphosphate 31-34 myosin heavy chain 14 Homo sapiens 232-238 33049993-8 2020 Computationally reconstructing ADP release from myosin by means of molecular dynamics simulations further supported the existence of an equivalent conformation along the power stroke that shows the same major characteristics in the myosin motor domain as the resolved blebbistatin-bound myosin-II ADP crystal structure, and identified a communication hub centered on Arg232 that mediates chemomechanical energy transduction. Adenosine Diphosphate 297-300 myosin heavy chain 14 Homo sapiens 48-54 32814440-7 2020 CONCLUSIONS: Together, our study highlights for the first time the influence of a hyperactive JAK2 on platelet activation-induced ADP secretion and dense granule homeostasis, with consequent effects on platelet activation properties. Adenosine Diphosphate 130-133 Janus kinase 2 Mus musculus 94-98 32539155-4 2020 Drp1 knockdown also led to a reduction in ADP-stimulated respiration, an increase in markers of impaired autophagy and increased muscle regeneration, denervation, fibrosis and oxidative stress. Adenosine Diphosphate 42-45 collapsin response mediator protein 1 Mus musculus 0-4 32539155-13 2020 Drp1 knockdown also led to a reduction in ADP-stimulated respiration and increases in markers of muscle regeneration, denervation, fibrosis, oxidative stress and impaired autophagy. Adenosine Diphosphate 42-45 collapsin response mediator protein 1 Mus musculus 0-4 32539231-10 2020 Platelet P-selectin expression at baseline and in response to adenosine diphosphate (ADP, 1 microM) stimulation was higher in nonsplenectomized and splenectomized HbE/beta-thal patients than healthy subjects. Adenosine Diphosphate 85-88 selectin P Homo sapiens 9-19 32601166-10 2020 This was supported by the notion that HAdV-B14 and B14p1 lacking ADP were highly sensitive to Nelfinavir, although HAdV-A31, B3, B7, B11, B16, B21, D8, D30 or D37 were less sensitive. Adenosine Diphosphate 65-68 NADH:ubiquinone oxidoreductase subunit A6 Homo sapiens 43-46 32539231-12 2020 Hb-bound platelets correlated with baseline P-selectin expression and ADP-induced P-selectin expression. Adenosine Diphosphate 70-73 selectin P Homo sapiens 82-92 32999463-5 2020 ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is expressed on microglia as well as other brain cells. Adenosine Diphosphate 94-97 5' nucleotidase, ecto Mus musculus 176-180 32360144-1 2020 BACKGROUND: BAG3 was identified as a co-chaperone of the heat shock protein (Hsp) 70, which helps, through the binding to the ATPase domain, the ADP release from the chaperone and the nucleotide cycling. Adenosine Diphosphate 145-148 heat shock protein family A (Hsp70) member 4 Homo sapiens 57-84 32065000-4 2020 Further, patients were genotyped for CYP2C19 *2 and *17 alleles.In prasugrel-treated patients, high ADP-induced platelet reactivity 1h after the loading dose positively correlated with 5OH-lansoprazole/lansoprazole ratio (r = 0.44, p = 0.002), a marker of CYP2C19 metabolic activity, and negatively with lansoprazole-sulfone/lansoprazole ratio, which reflects CYP3A4 metabolic activity (r = -0.35, p = 0.018).CYP2C19 poor metabolizers had lower 5OH-lansoprazole/lansoprazole ratio and higher lansoprazole-sulfone/lansoprazole ratio, but without any effect on the ADP-induced platelet reactivity. Adenosine Diphosphate 100-103 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 37-44 32065000-4 2020 Further, patients were genotyped for CYP2C19 *2 and *17 alleles.In prasugrel-treated patients, high ADP-induced platelet reactivity 1h after the loading dose positively correlated with 5OH-lansoprazole/lansoprazole ratio (r = 0.44, p = 0.002), a marker of CYP2C19 metabolic activity, and negatively with lansoprazole-sulfone/lansoprazole ratio, which reflects CYP3A4 metabolic activity (r = -0.35, p = 0.018).CYP2C19 poor metabolizers had lower 5OH-lansoprazole/lansoprazole ratio and higher lansoprazole-sulfone/lansoprazole ratio, but without any effect on the ADP-induced platelet reactivity. Adenosine Diphosphate 100-103 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 256-263 32065000-4 2020 Further, patients were genotyped for CYP2C19 *2 and *17 alleles.In prasugrel-treated patients, high ADP-induced platelet reactivity 1h after the loading dose positively correlated with 5OH-lansoprazole/lansoprazole ratio (r = 0.44, p = 0.002), a marker of CYP2C19 metabolic activity, and negatively with lansoprazole-sulfone/lansoprazole ratio, which reflects CYP3A4 metabolic activity (r = -0.35, p = 0.018).CYP2C19 poor metabolizers had lower 5OH-lansoprazole/lansoprazole ratio and higher lansoprazole-sulfone/lansoprazole ratio, but without any effect on the ADP-induced platelet reactivity. Adenosine Diphosphate 100-103 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 256-263 32065000-5 2020 The treatment with amiodarone, a CYP3A4 inhibitor, influenced neither the metabolic ratios nor the ADP-induced platelet reactivity.The CYP3A4 and CYP2C19 metabolic activity is associated with ADP-induced platelet reactivity in prasugrel-treated, but not ticagrelor-treated patients with STEMI. Adenosine Diphosphate 192-195 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 146-153 32733440-1 2020 Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). Adenosine Diphosphate 123-126 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 181-185 32675301-1 2020 BACKGROUND: The ADP-scavenging enzyme creatine kinase (CK) is reported to reduce ADP-dependent platelet activation. Adenosine Diphosphate 16-19 cytidine/uridine monophosphate kinase 1 Homo sapiens 2-4 32675301-1 2020 BACKGROUND: The ADP-scavenging enzyme creatine kinase (CK) is reported to reduce ADP-dependent platelet activation. Adenosine Diphosphate 81-84 cytidine/uridine monophosphate kinase 1 Homo sapiens 2-4 32675301-9 2020 This biologically plausible association warrants further prospective study of the potential role of extracellular CK in ADP-dependent platelet activation and bleeding. Adenosine Diphosphate 120-123 cytidine/uridine monophosphate kinase 1 Homo sapiens 114-116 32541931-9 2021 Higher KOR occupancy by naltrexone was associated with higher alcohol craving during the ADP (F1,81 = 4.88, p = 0.030). Adenosine Diphosphate 89-92 opioid receptor kappa 1 Homo sapiens 7-10 32390228-2 2020 Here, we use heterologous expression and whole-cell electrophysiology to investigate the regulation of the CLC isoforms ClC-3, ClC-4, and ClC-5 by the adenylic system components ATP, ADP, and AMP. Adenosine Diphosphate 183-186 Charcot-Leyden crystal galectin Homo sapiens 107-110 32390228-2 2020 Here, we use heterologous expression and whole-cell electrophysiology to investigate the regulation of the CLC isoforms ClC-3, ClC-4, and ClC-5 by the adenylic system components ATP, ADP, and AMP. Adenosine Diphosphate 183-186 chloride voltage-gated channel 5 Homo sapiens 138-143 32390228-3 2020 Our results show that cytosolic ATP and ADP but not AMP and Mg2+ -free ADP enhance CLC ion transport. Adenosine Diphosphate 40-43 Charcot-Leyden crystal galectin Homo sapiens 83-86 32390228-3 2020 Our results show that cytosolic ATP and ADP but not AMP and Mg2+ -free ADP enhance CLC ion transport. Adenosine Diphosphate 71-74 Charcot-Leyden crystal galectin Homo sapiens 83-86 32390228-7 2020 Our findings suggest that the CBS domains in mammalian CLC transporters serve as energy sensors that regulate vesicular Cl- /H+ exchange by detecting changes in the cytosolic ATP/ADP/AMP equilibrium. Adenosine Diphosphate 179-182 Charcot-Leyden crystal galectin Homo sapiens 55-58 32034076-1 2020 PURPOSE: Poly ADP-ribose inhibitors (PARPi) are efficacious in multiple cancers harboring germline (and possibly somatic) BRCA1/2 mutations. Adenosine Diphosphate 9-17 BRCA1 DNA repair associated Homo sapiens 122-127 32511412-4 2020 Mac1 likely counters host-mediated antiviral ADP-ribosylation, a posttranslational modification that is part of the host response to viral infections. Adenosine Diphosphate 45-48 integrin subunit alpha M Homo sapiens 0-4 32511412-6 2020 SARS-CoV-2, SARS-CoV and MERS-CoV Mac1 exhibit similar structural folds and ADP-ribose binding modes as shown by structural comparison. Adenosine Diphosphate 76-79 integrin subunit alpha M Homo sapiens 34-38 32431608-9 2020 Infusion of 5-10-sP (n = 5) and HSP10 (n = 5) into isolated hearts before I/R improved mitochondrial ADP-stimulated respiration, ATP production and prevented mitochondrial ROS formation compared to the I/R group (n = 5); this effect was abrogated by 5HD and chelerythrine. Adenosine Diphosphate 101-104 heat shock protein family E (Hsp10) member 1 Rattus norvegicus 32-37 32431608-11 2020 5HD reduced the ADP-stimulated respiration in the HSP10 group (65.84 +- 3.3 nmol O2/min/mg PTN), ATP production (193.7 +- 12.1 mumol ATP/200mug PTN) and increased ROS in the 5-10-sP group (274.4 +- 21.7 nmol H2O2/200 mug PTN). Adenosine Diphosphate 16-19 heat shock protein family E (Hsp10) member 1 Rattus norvegicus 50-55 32155290-8 2020 Secondary ATP liberation induced by low level (50 nM) of exoATP was reduced by inhibiting ecto-ATPase-dependent ADP production with ARL67156, or blocking P2 receptors with suramin or PPADS, or with specific P2Y13 receptor antagonist MRS2211, or siRNA. Adenosine Diphosphate 112-115 CEA cell adhesion molecule 1 Rattus norvegicus 90-101 32303740-7 2020 The expression levels of ATF3 and P2X3 were measured using qRT-PCR, western blot analysis and immunofluorescence analysis after adenosine 5"-diphosphate (ADP) exposure in DRG cells. Adenosine Diphosphate 154-157 activating transcription factor 3 Rattus norvegicus 25-29 32303740-13 2020 CHIP and luciferase assay showed that ADP increased the binding of ATF3 to the P2X3 promoter, resulting in an increase in P2X3 expression levels. Adenosine Diphosphate 38-41 activating transcription factor 3 Rattus norvegicus 67-71 31935437-6 2020 ADP-stimulated respiration with glutamate and malate was reduced in the Wfs1-deficient cardiac as well as oxidative and glycolytic skeletal muscles. Adenosine Diphosphate 0-3 wolframin ER transmembrane glycoprotein Mus musculus 72-76 31793068-2 2020 The ability of poly(ADP-ribose) polymerase 1 (PARP1) to poly-ADP-ribosylate NFATc1 in T cells prompted us to investigate the PARP1 and NFATc1 interaction during osteoclastogenesis. Adenosine Diphosphate 56-64 poly (ADP-ribose) polymerase family, member 1 Mus musculus 15-44 31793068-2 2020 The ability of poly(ADP-ribose) polymerase 1 (PARP1) to poly-ADP-ribosylate NFATc1 in T cells prompted us to investigate the PARP1 and NFATc1 interaction during osteoclastogenesis. Adenosine Diphosphate 56-64 poly (ADP-ribose) polymerase family, member 1 Mus musculus 46-51 31793068-5 2020 These unbiased approaches in conjunction with site-directed mutagenesis studies revealed that PARP1 inhibited NFATc1 expression and OC formation by ADP-ribosylating histone H2B at serine 7 and decreasing the occupancy of this histone variant at the NFATc1 promoter. Adenosine Diphosphate 148-151 poly (ADP-ribose) polymerase family, member 1 Mus musculus 94-99 32000030-9 2020 In vitro, we confirmed that GDF-15 significantly reduced platelet aggregation induced by ADP and the effect was concentration-dependent (P < 0.001). Adenosine Diphosphate 89-92 growth differentiation factor 15 Homo sapiens 28-34 32000030-11 2020 CONCLUSIONS: Increased GDF-15 level was associated with more thrombus severity of DVT patients and GDF-15 could inhibit platelet aggregation induced by ADP in vitro. Adenosine Diphosphate 152-155 growth differentiation factor 15 Homo sapiens 99-105 31931718-11 2020 In addition, SAA decreased the expressions of PAC-1 and CD62p, which were enhanced by ADP and thrombin (all P < 0.01). Adenosine Diphosphate 86-89 serum amyloid A1 cluster Homo sapiens 13-16 31531757-5 2020 At neutral pH, initial ATPase activity would be mostly due to NTPDase2, which was thereafter inactivated, leaving NTPDase1 and NTPDase3 to hydrolyse ATP and ADP with an efficacy ATPase/ADPase around 2. Adenosine Diphosphate 157-160 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 62-70 31531757-5 2020 At neutral pH, initial ATPase activity would be mostly due to NTPDase2, which was thereafter inactivated, leaving NTPDase1 and NTPDase3 to hydrolyse ATP and ADP with an efficacy ATPase/ADPase around 2. Adenosine Diphosphate 157-160 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 127-135 30937822-10 2019 Purified Pho5 showed a similar activity with p-nitrophenylphosphate, ATP, ADP, glycerophosphate, and glucose-6-phosphate. Adenosine Diphosphate 74-77 acid phosphatase PHO5 Saccharomyces cerevisiae S288C 9-13 31548257-5 2019 The ADP-ribosylation activity of AvrRpm1 is required for subsequent phosphorylation on threonine 166 of Arabidopsis RIN4, an event that is necessary and sufficient for RPM1 activation. Adenosine Diphosphate 4-7 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 168-172 31202885-5 2019 Under ATP turnover conditions, Grp94 populates two distinct closed states, a relatively static ATP/ATP closed state that adopts one conformation, and a dynamic ATP/ADP closed state that can adopt two conformations. Adenosine Diphosphate 164-167 heat shock protein 90 beta family member 1 Homo sapiens 31-36 31202885-6 2019 We constructed a Grp94 heterodimer with one arm that is catalytically dead, to extend the lifetime of the ATP/ADP state by preventing hydrolysis of the second ATP. Adenosine Diphosphate 110-113 heat shock protein 90 beta family member 1 Homo sapiens 17-22 31772608-11 2019 Conclusions: CYP2C19 and PON1 Q192R variants influence ADP-induced platelet inhibition by thrombelastography (TEG) in ACS patients with clopidogrel. Adenosine Diphosphate 55-58 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 13-20 30848916-8 2019 IFN-gamma increased the ADP-ribosylation status of ARTD9/PARP9, ARTD8/PARP14, and proteins involved in RNA processes. Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase family member 14 Homo sapiens 64-69 30848916-8 2019 IFN-gamma increased the ADP-ribosylation status of ARTD9/PARP9, ARTD8/PARP14, and proteins involved in RNA processes. Adenosine Diphosphate 24-27 poly(ADP-ribose) polymerase family member 14 Homo sapiens 70-76 30872815-4 2019 The high-resolution structure reveals local DNA distortion and translocation induced by ISW1 in the ADP-bound state, which is essentially identical to that induced by the Snf2 chromatin remodeler, suggesting a common mechanism of DNA translocation. Adenosine Diphosphate 100-103 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 171-175 30867599-5 2019 Here we report the structures of Saccharomyces cerevisiae Snf2 bound to the nucleosome in the presence of ADP and ADP-BeFx. Adenosine Diphosphate 106-109 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 58-62 30867599-6 2019 Snf2 in the ADP-bound state adopts an open conformation similar to that in the apo state, and induces a one-base-pair DNA bulge at superhelix location 2 (SHL2), with the tracking strand showing greater distortion than the guide strand. Adenosine Diphosphate 12-15 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 0-4 30672289-6 2019 Here, we report two high-resolution crystal structures of ZIKV NS3 helicase in complex with adenosine diphosphate (ADP) and Mn2+, one with the reactant water already loaded as previously observed and the other with the water molecule still in a loading state. Adenosine Diphosphate 92-113 KRAS proto-oncogene, GTPase Homo sapiens 63-66 30672289-6 2019 Here, we report two high-resolution crystal structures of ZIKV NS3 helicase in complex with adenosine diphosphate (ADP) and Mn2+, one with the reactant water already loaded as previously observed and the other with the water molecule still in a loading state. Adenosine Diphosphate 115-118 KRAS proto-oncogene, GTPase Homo sapiens 63-66 30672289-7 2019 These data suggest that the reactant water replenishment can occur between the release of phosphate and the release of ADP and improves the structural basis of the NS3 ATP hydrolysis cycle. Adenosine Diphosphate 119-122 KRAS proto-oncogene, GTPase Homo sapiens 164-167 30691122-1 2019 Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). Adenosine Diphosphate 29-32 poly (ADP-ribose) polymerase family, member 1 Mus musculus 147-152 30691122-1 2019 Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). Adenosine Diphosphate 29-32 poly (ADP-ribose) polymerase family, member 1 Mus musculus 162-168 30691122-1 2019 Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). Adenosine Diphosphate 29-32 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Mus musculus 178-189 30691122-1 2019 Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). Adenosine Diphosphate 29-32 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Mus musculus 208-216 30679749-6 2019 We have identified HSPA12A as a new adaptor protein that, among Vps10p-D receptors, selectively binds to SorLA in an ADP/ATP dependent manner. Adenosine Diphosphate 117-120 sortilin related receptor 1 Homo sapiens 105-110 30478170-5 2019 This mode of activation is reminiscent of that of ADP, which activates AMPK by binding to the nucleotide-binding sites in the gamma-subunit, more than 60 A away from the ADaM site. Adenosine Diphosphate 50-53 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 71-75 30204045-5 2019 PCs were tested for platelet count, light transmission aggregation (LTA) induced by ADP, collagen, or TRAP; platelet ATP release induced by collagen; and spontaneous and ADP and TRAP-induced increase in CD62P and PAC1 expression measured by flow cytometry. Adenosine Diphosphate 84-87 TRAP Homo sapiens 178-182 30385511-11 2018 In summary, our findings, taken together, support a mechanism (detailed within) wherein succinate-energized respiration as a function of increasing [ADP] is initially increased by [ADP]-dependent effects on membrane potential but subsequently decreased at higher [ADP] by inhibition of succinate dehydrogenase by OAA. Adenosine Diphosphate 149-152 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 286-309 30385511-11 2018 In summary, our findings, taken together, support a mechanism (detailed within) wherein succinate-energized respiration as a function of increasing [ADP] is initially increased by [ADP]-dependent effects on membrane potential but subsequently decreased at higher [ADP] by inhibition of succinate dehydrogenase by OAA. Adenosine Diphosphate 181-184 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 286-309 30385511-11 2018 In summary, our findings, taken together, support a mechanism (detailed within) wherein succinate-energized respiration as a function of increasing [ADP] is initially increased by [ADP]-dependent effects on membrane potential but subsequently decreased at higher [ADP] by inhibition of succinate dehydrogenase by OAA. Adenosine Diphosphate 181-184 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 286-309 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 75-96 transient receptor potential cation channel subfamily M member 2 Homo sapiens 36-42 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 75-96 transient receptor potential cation channel subfamily M member 2 Homo sapiens 168-173 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 98-101 transient receptor potential cation channel subfamily M member 2 Homo sapiens 36-42 30467180-2 2018 It has a C-terminal NUDT9 homology (NUDT9H) domain responsible for binding adenosine diphosphate (ADP)-ribose (ADPR), and both ADPR and calcium (Ca2+) are required for TRPM2 activation. Adenosine Diphosphate 98-101 transient receptor potential cation channel subfamily M member 2 Homo sapiens 168-173 30359575-2 2018 The DNA bound protein PARP (poly ADP ribose) polymerase catalyses a post translational modification (polymerization of negatively charged ADP-ribose chains) of nuclear proteins. Adenosine Diphosphate 33-36 poly (ADP-ribose) polymerase family, member 1 Mus musculus 22-26 30419596-10 2018 Moreover, recombinant PLTP together with ADP significantly increased phosphatidylserine exposure on the plasma membrane of PLTP-deficient platelets, thereby increasing fibrinogen binding. Adenosine Diphosphate 41-44 phospholipid transfer protein Mus musculus 123-127 30419596-12 2018 We concluded that PLTP promotes phosphatidylserine externalization at the plasma membrane of platelets and accelerates ADP- or collagen-induced platelet aggregation. Adenosine Diphosphate 119-122 phospholipid transfer protein Mus musculus 18-22 29984433-0 2018 Adenosine diphosphate regulates MMP2 and MMP9 activity in malignant mesothelioma cells. Adenosine Diphosphate 0-21 matrix metallopeptidase 9 Homo sapiens 41-45 30177759-0 2018 Reply to "Concerns with yeast mitochondrial ADP/ATP carrier"s integrity in DPC" and "Dynamics and interactions of AAC3 in DPC are not functionally relevant". Adenosine Diphosphate 44-47 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 114-118 30144157-7 2018 In addition, ADP (100 microM) can induce the formation of cytosolic autophagy in endothelial cells and a rapid phosphorylation of extracellular signal regulated kinase (ERK) 1/2, which is a canonical signal molecule downstream of P2Y receptors, accompanied by a mRNA expression of proinflammatory cytokines such as intercellular adhesion molecule 1 and vascular cell adhesion molecule 1. Adenosine Diphosphate 13-16 intercellular adhesion molecule 1 Homo sapiens 315-348 29902700-13 2018 Ticagrelor and a JNK inhibitor ameliorated impairment of endothelium-dependent vasodilation by adenosine diphosphate (ADP) in wild-type mouse aortic segments. Adenosine Diphosphate 95-116 mitogen-activated protein kinase 8 Mus musculus 17-20 29902700-13 2018 Ticagrelor and a JNK inhibitor ameliorated impairment of endothelium-dependent vasodilation by adenosine diphosphate (ADP) in wild-type mouse aortic segments. Adenosine Diphosphate 118-121 mitogen-activated protein kinase 8 Mus musculus 17-20 29902700-15 2018 Ticagrelor also inhibited ADP-induced JNK activation in HUVEC (p < 0.05). Adenosine Diphosphate 26-29 mitogen-activated protein kinase 8 Mus musculus 38-41 29682760-11 2018 Compared to Park2+/+ muscles, the mitochondrial function of Park2-/- skeletal muscles was significantly impaired, as indicated by the significant decrease in ADP-stimulated mitochondrial respiratory rates, uncoupling, reduced activities of respiratory chain complexes containing mitochondrial DNA (mtDNA)-encoded subunits and increased susceptibility to opening of the permeability transition pore. Adenosine Diphosphate 158-161 parkin RBR E3 ubiquitin protein ligase Mus musculus 60-65 29559479-3 2018 We found that ibrutinib and the novel Btk inhibitors acalabrutinib and ONO/GS-4059 block GPVI-dependent static platelet aggregation in blood exposed to human plaque homogenate and collagen but not to ADP or arachidonic acid. Adenosine Diphosphate 200-203 Bruton tyrosine kinase Homo sapiens 38-41 29942314-1 2018 Objectives: CD39 and CD73 are surface enzymes that jut into the extracellular space where they mediate the step-wise phosphohydrolysis of the autocrine and paracrine danger signals ATP and ADP into anti-inflammatory adenosine. Adenosine Diphosphate 189-192 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-16 29574692-5 2018 KEY RESULTS: ADP-evoked intracellular Ca2+ responses (EC50 2.7 muM) in THP-1 cells were abolished by inhibition of PLC (U73122) or sarco/endoplasmic reticulum Ca2+ -ATPase (thapsigargin). Adenosine Diphosphate 13-16 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 131-171 29401626-5 2018 Irrespective of diet, BRCA1KOsmi mice exhibited significantly lower ADP-stimulated complex I mitochondrial respiration rates compared to age-matched wild-type (WT) mice. Adenosine Diphosphate 68-71 breast cancer 1, early onset Mus musculus 22-27 29880349-0 2018 Mechanism of Nucleoside Triphosphate Diphosphohydrolase-1-Associated Imbalance in Adenosine Diphosphate Degradation, B-Cell Activation, and Related Injury During Acute Antibody-Mediated Rejection. Adenosine Diphosphate 82-103 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 13-57 29880349-4 2018 RESULTS: During acute AMR in nude mice, higher NTPDase1 expression caused lower extracellular ADP concentration, smaller increase in B-cell volume, and major histocompatibility complex II surface antigen expression, suggesting a negative correlation between them; higher NTPDase1 expression also caused slower average platelet transport rate and less severe skin graft injury, suggesting a negative correlation between them. Adenosine Diphosphate 94-97 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 47-55 29880349-6 2018 CONCLUSION: An NTPDase1-associated imbalance in extracellular ADP degradation may contribute to B-cell activation, platelet activation, and more severe skin graft injury in nude mice. Adenosine Diphosphate 62-65 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 15-23 29685928-2 2018 These hetero-octameric channels, comprising four inward rectifier K+ channel subunits (Kir6.1 or Kir6.2) and four sulfonylurea receptor (SUR1 or SUR2A/B) subunits, detect metabolic changes via three classes of intracellular adenine nucleotide (ATP/ADP) binding site. Adenosine Diphosphate 248-251 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 97-103 29431122-1 2018 OBJECTIVES: The enzyme poly(ADP-ribose) polymerase-1 (PARP-1) transfers negatively charged ADP-ribose units to target proteins. Adenosine Diphosphate 28-31 poly (ADP-ribose) polymerase family, member 1 Mus musculus 54-60 29863272-7 2018 RESULTS: Administration of progranulin resulted in a significant inhibition of platelet aggregation in response to both adenosine diphosphate, and arachidonic acid. Adenosine Diphosphate 120-141 granulin precursor Rattus norvegicus 27-38 29346611-6 2018 Of the analogues tested, the addition of ATP transition state analogue ADP-AlFx further assisted in the complete activation of RIG-I in complex with 10bp and also to some extent RIG-I bound to 8bp. Adenosine Diphosphate 71-74 DExD/H-box helicase 58 Homo sapiens 127-132 29346611-6 2018 Of the analogues tested, the addition of ATP transition state analogue ADP-AlFx further assisted in the complete activation of RIG-I in complex with 10bp and also to some extent RIG-I bound to 8bp. Adenosine Diphosphate 71-74 DExD/H-box helicase 58 Homo sapiens 178-183 29522284-8 2018 Additionally, AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) in the PI3K/AKT/ARNT signaling pathway, which promoted apoptosis and necrosis in GC cells. Adenosine Diphosphate 14-17 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 46-49 29522284-8 2018 Additionally, AdP inhibited the expression of p85, AKT, p-p85, p-AKT, multidrug resistance 1 (MDR1), and aryl hydrocarbon nuclear translocator (ARNT) in the PI3K/AKT/ARNT signaling pathway, which promoted apoptosis and necrosis in GC cells. Adenosine Diphosphate 14-17 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 58-61 29475177-13 2018 These data further support the role of periprocedural Gp IIb-IIIa inhibitors in order to overcome any suboptimal inhibition of platelet aggregation at the time of the procedure due to drug-resistance or delayed (downstream) administration of ADP antagonists, especially in complex high-risk procedures. Adenosine Diphosphate 242-245 integrin subunit alpha 2b Homo sapiens 54-60 29177659-2 2018 Nucleotide exchange factors (NEFs) accelerate ADP release from Hsp70, which results in rebinding of ATP and release of the substrate, thereby regulating the lifetime of the Hsp70-substrate complex. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 63-68 29177659-2 2018 Nucleotide exchange factors (NEFs) accelerate ADP release from Hsp70, which results in rebinding of ATP and release of the substrate, thereby regulating the lifetime of the Hsp70-substrate complex. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 173-178 30166707-4 2018 CD39, the main endothelial ectonucleotidase which cleaves ATP and ADP, plays an essential role in ridding the bloodstream of these danger signals, thereby sustaining vascular homeostasis. Adenosine Diphosphate 66-69 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 28748912-7 2017 Kinetic analyses were performed using a luminescent ADP detection assay by varying the concentrations of a peptide substrate, and the results showed that the mutations I78C and I78W decreased CK2alpha activity, whereas V31R, K75E, I82C and P109C increased CK2alpha activity. Adenosine Diphosphate 52-55 casein kinase 2 alpha 2 Homo sapiens 192-200 21071695-8 2010 CONCLUSIONS: These data suggest that the P2Y12 receptor not only is central to ADP-induced platelet activation but also may mediate platelet-independent responses, specifically under conditions of enhanced thrombin formation, such as local vessel injury and atherosclerotic plaque rupture. Adenosine Diphosphate 79-82 purinergic receptor P2Y12 Homo sapiens 41-46 29335059-4 2017 Four single nucleotide polymorphisms (SNPs) of ADRA2A gene (rs11195419, rs3750625, rs13306146, and rs553668) and CYP2C19*2 were detected by ligase detection reaction (LDR), and adenosine diphosphate (ADP) inhibition was detected by thromboelastography (TEG ). Adenosine Diphosphate 177-198 adrenoceptor alpha 2A Homo sapiens 47-53 21095583-5 2010 PARP-1 dissociates Smad complexes from DNA by ADP-ribosylating Smad3 and Smad4, which attenuates Smad-specific gene responses and TGF-beta-induced epithelial-mesenchymal transition. Adenosine Diphosphate 46-49 SMAD family member 4 Homo sapiens 19-23 29335059-4 2017 Four single nucleotide polymorphisms (SNPs) of ADRA2A gene (rs11195419, rs3750625, rs13306146, and rs553668) and CYP2C19*2 were detected by ligase detection reaction (LDR), and adenosine diphosphate (ADP) inhibition was detected by thromboelastography (TEG ). Adenosine Diphosphate 177-198 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 113-120 21095583-5 2010 PARP-1 dissociates Smad complexes from DNA by ADP-ribosylating Smad3 and Smad4, which attenuates Smad-specific gene responses and TGF-beta-induced epithelial-mesenchymal transition. Adenosine Diphosphate 46-49 SMAD family member 3 Homo sapiens 63-68 29335059-4 2017 Four single nucleotide polymorphisms (SNPs) of ADRA2A gene (rs11195419, rs3750625, rs13306146, and rs553668) and CYP2C19*2 were detected by ligase detection reaction (LDR), and adenosine diphosphate (ADP) inhibition was detected by thromboelastography (TEG ). Adenosine Diphosphate 200-203 adrenoceptor alpha 2A Homo sapiens 47-53 29335059-4 2017 Four single nucleotide polymorphisms (SNPs) of ADRA2A gene (rs11195419, rs3750625, rs13306146, and rs553668) and CYP2C19*2 were detected by ligase detection reaction (LDR), and adenosine diphosphate (ADP) inhibition was detected by thromboelastography (TEG ). Adenosine Diphosphate 200-203 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 113-120 29335059-9 2017 At the multivariate analysis, rs11195419 (P = 0.033), rs3750625 (P = 0.020) and CYP2C19*2 (P = 0.002) were independent predictors of ADP inhibition. Adenosine Diphosphate 133-136 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 80-87 29335059-11 2017 CONCLUSION: ADRA2A genetic variations were associated with ADP-induced platelet aggregation during DAPT in Chinese patients undergoing PCI, and the effect was particularly more pronounced in males. Adenosine Diphosphate 59-62 adrenoceptor alpha 2A Homo sapiens 12-18 20655932-7 2010 Furthermore, the hydrolysis of ATP, ADP, AMP, and p-Nph-5"TMP was also increased (17%, 35%, 27%, 20%, respectively) as was the gene expression of NTPDase2, NTPDase3 and NPP3 in kidneys of hypertensive animals. Adenosine Diphosphate 36-39 ectonucleotide pyrophosphatase/phosphodiesterase 3 Rattus norvegicus 169-173 29126301-3 2017 Platelet-derived ADP and thromboxane activate non-adhered platelets via their GPIIb/IIIa receptors, allowing these platelets to participate in platelet aggregation. Adenosine Diphosphate 17-20 integrin subunit alpha 2b Homo sapiens 78-83 29163045-2 2017 Given that NTPDase2 hydrolyzes ATP with a transient accumulation of ADP, the expression of ADP-sensitive P2 purinoceptors was analyzed as well. Adenosine Diphosphate 68-71 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 11-19 20510224-6 2010 AICAR treatment also significantly influenced the concentrations of cellular adenylates (ATP, ADP, and AMP). Adenosine Diphosphate 94-97 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 0-5 20421285-9 2010 Thus, mucin granules contribute to ATP release and also are a source of extracellular ADP and AMP. Adenosine Diphosphate 86-89 LOC100508689 Homo sapiens 6-11 20421285-10 2010 Direct release of ADP/AMP from mucin granules is likely to provide a major source of airway surface adenosine to signal in a paracrine faction ciliated cell A(2b) receptors to activate ion/water secretion and appropriately hydrate goblet cell-released mucins. Adenosine Diphosphate 18-21 LOC100508689 Homo sapiens 31-36 20357135-1 2010 The chloroplast thylakoid ATP/ADP carrier (TAAC) belongs to the mitochondrial carrier superfamily and supplies the thylakoid lumen with stromal ATP in exchange for ADP. Adenosine Diphosphate 30-33 thylakoid ATP/ADP carrier Arabidopsis thaliana 43-47 20357135-1 2010 The chloroplast thylakoid ATP/ADP carrier (TAAC) belongs to the mitochondrial carrier superfamily and supplies the thylakoid lumen with stromal ATP in exchange for ADP. Adenosine Diphosphate 164-167 thylakoid ATP/ADP carrier Arabidopsis thaliana 43-47 29163045-2 2017 Given that NTPDase2 hydrolyzes ATP with a transient accumulation of ADP, the expression of ADP-sensitive P2 purinoceptors was analyzed as well. Adenosine Diphosphate 91-94 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 11-19 29026172-4 2017 Using calorimetry, and high resolution respirometry coupled with fluorimetry, we report substrate oxidation by mGPDH in permeabilised flight muscles operates, in vitro, at a high flux, even in the absence of ADP. Adenosine Diphosphate 208-211 glycerol phosphate dehydrogenase 2, mitochondrial Mus musculus 111-116 20121703-8 2010 Furthermore, denatured proteins decrease the inhibitory influence of ADP on ATP-induced association of GroES to the trans-ring of GroEL. Adenosine Diphosphate 69-72 heat shock protein family E (Hsp10) member 1 Homo sapiens 103-108 20121703-9 2010 From these findings we conclude that denatured proteins facilitate the dissociation of ADP from the trans-ring of GroEL and the concomitant association of ATP and the second GroES. Adenosine Diphosphate 87-90 heat shock protein family E (Hsp10) member 1 Homo sapiens 174-179 28994403-2 2017 Previous X-ray crystallographic analyses of HSP70 have shown that HSP70 binds to ADP with internal water molecules. Adenosine Diphosphate 81-84 heat shock protein family A (Hsp70) member 4 Homo sapiens 66-71 29031721-18 2017 We identified novel protein interactors of CDKAL1, including SLC25A4/ANT1, an inner mitochondrial membrane ADP/ATP translocator. Adenosine Diphosphate 107-110 CDK5 regulatory subunit associated protein 1-like 1 Mus musculus 43-49 28822683-7 2017 ADP inhibition of bacterial Hsp90 can be relieved by bacterial Hsp70 and an activating client protein. Adenosine Diphosphate 0-3 heat shock protein family A (Hsp70) member 4 Homo sapiens 63-68 20146535-6 2010 We found that LRRK2 follows a rapid equilibrium random mechanism for the phosphorylation of PLK-peptide with either ATP or PLK-peptide being the first substrate binding to the enzyme, as evidenced by initial velocity and inhibition mechanism studies with nucleotide analogues AMP and AMP-PNP, product ADP, and an analogue of the peptide substrate. Adenosine Diphosphate 301-304 leucine-rich repeat kinase 2 Mus musculus 14-19 28615457-2 2017 AMPK senses the ratio of adenine nucleotides (adenylate energy charge) by competitive binding of AMP, ADP, and ATP to three sites (CBS1, CBS3, and CBS4) in its gamma-subunit. Adenosine Diphosphate 102-105 methionine sulfoxide reductase B2 Homo sapiens 131-135 28255014-4 2017 The FLI1 variant carriers" platelets exhibited a defect in aggregation induced by low-dose adenosine diphosphate (ADP), collagen and thrombin receptor-activating peptide (TRAP), a defect in adenosine triphosphate (ATP) secretion, a reduced mepacrine uptake and release and a reduced CD63 expression upon TRAP stimulation. Adenosine Diphosphate 91-112 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 4-8 20083109-0 2010 ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle. Adenosine Diphosphate 14-17 heat shock protein family E (Hsp10) member 1 Homo sapiens 63-68 28255014-4 2017 The FLI1 variant carriers" platelets exhibited a defect in aggregation induced by low-dose adenosine diphosphate (ADP), collagen and thrombin receptor-activating peptide (TRAP), a defect in adenosine triphosphate (ATP) secretion, a reduced mepacrine uptake and release and a reduced CD63 expression upon TRAP stimulation. Adenosine Diphosphate 114-117 Fli-1 proto-oncogene, ETS transcription factor Homo sapiens 4-8 29926635-1 2017 OBJECTIVE: To investigate the effects of adiponectin(ADP) postconditioning against myocardial ischemia/reperfusion injury(MIRI) in rats and role of ADP/PI3K/Akt pathway in ADP postconditioning. Adenosine Diphosphate 53-56 adiponectin, C1Q and collagen domain containing Rattus norvegicus 41-52 20007455-3 2010 Herein, we demonstrate that site mutations of ANT1 (Y190-->F190, Y194-->F194) mimicking dephosphorylation of the aromatic ladder resulted in loss of oxidative growth and ADP/ATP exchange activity in respiration-incompetent yeast expressing mutant chimeric yN-hANT1. Adenosine Diphosphate 176-179 Ant1p Saccharomyces cerevisiae S288C 46-50 28143925-5 2017 Here, we demonstrated that the CHIKV nsP3 macrodomain is able to hydrolyze ADP-ribose groups from mono(ADP-ribosyl)ated proteins. Adenosine Diphosphate 75-78 SH2 domain containing 3C Homo sapiens 37-41 20033706-4 2010 RESULTS AND DISCUSSION: The protein FHIT catalyzes the Mg(2+) dependent hydrolysis of P1-5 cent-O-adenosine-P3-5 cent-O-adenosine triphosphate, Ap3A, to AMP, and ADP. Adenosine Diphosphate 162-165 fragile histidine triad diadenosine triphosphatase Homo sapiens 36-40 27694622-0 2017 The beta-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing. Adenosine Diphosphate 35-38 BRCA2 and CDKN1A interacting protein Homo sapiens 20-25 19900551-12 2010 Ductal injection of oxygenated PFC significantly reduced ADP/ATP ratio (8.57+/-0.6 vs. 14.2+/-2.4, p<0.03) and improved intracellular energy charge (0.36+/-0.05 vs. 0.22+/-0.03, p<0.001) as compared to HBSS group. Adenosine Diphosphate 57-60 complement factor properdin Rattus norvegicus 31-34 27694622-0 2017 The beta-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing. Adenosine Diphosphate 35-38 RAD51 recombinase Homo sapiens 56-61 20653328-2 2010 Since adenosine diphosphate (ADP) represents one of the most important mediators of thrombosis, the inhibition of the platelet ADP receptor, in particular the P2Y12 subtype, plays a pivotal role in secondary prevention of recurrent atherothrombotic events in high-risk settings. Adenosine Diphosphate 6-27 purinergic receptor P2Y12 Homo sapiens 159-164 27694622-10 2017 Notably, this stimulatory effect is not the result of RAD51 nucleoprotein filament stabilization; rather, we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament. Adenosine Diphosphate 219-222 BRCA2 and CDKN1A interacting protein Homo sapiens 126-135 20653328-2 2010 Since adenosine diphosphate (ADP) represents one of the most important mediators of thrombosis, the inhibition of the platelet ADP receptor, in particular the P2Y12 subtype, plays a pivotal role in secondary prevention of recurrent atherothrombotic events in high-risk settings. Adenosine Diphosphate 29-32 purinergic receptor P2Y12 Homo sapiens 159-164 20472150-8 2010 Therefore, GSK-3beta/beta-catenin pathway may be important in the reciprocal actions of GCs and Li on ADP proliferation. Adenosine Diphosphate 102-105 glycogen synthase kinase 3 beta Rattus norvegicus 11-20 19915138-2 2009 The physiological order of addition of ATP and nonnative polypeptide, typically to the open trans ring of an asymmetrical GroEL/GroES/ADP complex, has been unknown, although there have been assumptions that polypeptide binds first, allowing subsequent ATP-mediated movement of the GroEL apical domains to exert an action of forceful unfolding on the nonnative polypeptide. Adenosine Diphosphate 134-137 heat shock protein family E (Hsp10) member 1 Homo sapiens 128-133 19840793-0 2009 Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions. Adenosine Diphosphate 38-41 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-62 19850043-1 2009 Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. Adenosine Diphosphate 150-153 platelet and endothelial cell adhesion molecule 1 Homo sapiens 0-45 19850043-1 2009 Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits platelet response to collagen and may also inhibit two other major platelet agonists ADP and thrombin although this has been less well explored. Adenosine Diphosphate 150-153 platelet and endothelial cell adhesion molecule 1 Homo sapiens 47-54 19822647-5 2009 P2Y12 receptor expression by LAD2 cells is required for competition between radiolabeled ADP and unlabeled LTE4 but not for direct binding of LTE4, suggesting that P2Y12 complexes with another receptor to recognize LTE4. Adenosine Diphosphate 89-92 purinergic receptor P2Y12 Homo sapiens 0-5 19822647-5 2009 P2Y12 receptor expression by LAD2 cells is required for competition between radiolabeled ADP and unlabeled LTE4 but not for direct binding of LTE4, suggesting that P2Y12 complexes with another receptor to recognize LTE4. Adenosine Diphosphate 89-92 purinergic receptor P2Y12 Homo sapiens 164-169 19828438-8 2009 More specifically, intramolecular strain causes the myosin VI lever arm of the lead head to uncouple from the motor domain, allowing the motor domain to go through its product-release (phosphate and ADP) steps at an unstrained rate. Adenosine Diphosphate 199-202 myosin VI Homo sapiens 52-61 19559024-4 2009 alphaB-crystallin attenuated the adenosine diphosphate (ADP)-induced phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK. Adenosine Diphosphate 33-54 interferon induced protein 44 Homo sapiens 88-91 19559024-4 2009 alphaB-crystallin attenuated the adenosine diphosphate (ADP)-induced phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK. Adenosine Diphosphate 56-59 interferon induced protein 44 Homo sapiens 88-91 19604122-5 2009 Cangrelor is a potent, competitive inhibitor of the P2Y12 receptor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation. Adenosine Diphosphate 161-164 purinergic receptor P2Y12 Homo sapiens 52-57 19630813-6 2009 Ticagrelor is the first of a new class of orally available antiplatelet agents antagonizing the effects of ADP mediated by P2Y12; it is currently being studied in a phase III trial in patients with ACS. Adenosine Diphosphate 107-110 purinergic receptor P2Y12 Homo sapiens 123-128 19346255-1 2009 ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 128-133 19346255-3 2009 Specifically, the results have indicated that although P2Y1 receptors are involved in the initiation of platelet aggregation, P2Y12 receptor activation appears to account for the bulk of the ADP-mediated effects. Adenosine Diphosphate 191-194 purinergic receptor P2Y12 Homo sapiens 126-131 19441828-3 2009 Here we discovered that small molecules directly conjugated to the 5"-diphosphate moiety of ADP can serve as the substrates of a mutant Sfp PPTase, R4-4. Adenosine Diphosphate 92-95 CD1a molecule Homo sapiens 148-152 19327367-6 2009 We show that Rad51 readily dissociates from DNA in the presence of ADP or in the absence of nucleotide cofactor, but that free ATP in solution confers a fivefold increase in the stability of the nucleoprotein filaments. Adenosine Diphosphate 67-70 recombinase RAD51 Saccharomyces cerevisiae S288C 13-18 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 151-154 mutS homolog 2 Homo sapiens 90-94 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 151-154 mutS homolog 2 Homo sapiens 141-145 19377479-4 2009 Subsequent ATP binding and hydrolysis in the MSH3 subunit promote ADP-ATP exchange in the MSH2 subunit to yield a hydrolysis-independent ATP-MSH2-MSH3-ADP intermediate. Adenosine Diphosphate 151-154 mutS homolog 3 Homo sapiens 146-150 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mutS homolog 2 Homo sapiens 6-10 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mutS homolog 3 Homo sapiens 11-15 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mutS homolog 2 Homo sapiens 6-10 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mutS homolog 3 Homo sapiens 11-15 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair protein MSH3 Saccharomyces cerevisiae S288C 275-279 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mutS homolog 2 Homo sapiens 6-10 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mutS homolog 3 Homo sapiens 11-15 18798562-5 2009 Herein, we report the characterization of substrate induced changes (Mg-ADP, M5P, and the ternary complex) in PMK using NMR-based dynamics and chemical shift perturbation measurements. Adenosine Diphosphate 69-75 phosphomevalonate kinase Homo sapiens 110-113 19167530-1 2009 Adenine nucleotide translocase (Ant) mediates the exchange of ADP and ATP across the inner mitochondrial membrane in eukaryotes. Adenosine Diphosphate 62-65 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 0-30 19167530-1 2009 Adenine nucleotide translocase (Ant) mediates the exchange of ADP and ATP across the inner mitochondrial membrane in eukaryotes. Adenosine Diphosphate 62-65 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 Mus musculus 32-35 18815870-7 2009 Further, ADP-induced platelet aggregation was suppressed in PEDF-treated rats. Adenosine Diphosphate 9-12 serpin family F member 1 Rattus norvegicus 60-64 19121335-6 2009 ADP, one of the most characterized GDH activators was found to stabilize a specific protein conformation resulting in loss of propensity to aggregate. Adenosine Diphosphate 0-3 glutamate dehydrogenase 1, mitochondrial Bos taurus 35-38 19005466-11 2009 These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders. Adenosine Diphosphate 133-136 glycogen synthase kinase 3 beta Rattus norvegicus 27-36 27694622-10 2017 Notably, this stimulatory effect is not the result of RAD51 nucleoprotein filament stabilization; rather, we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament. Adenosine Diphosphate 219-222 RAD51 recombinase Homo sapiens 179-184 28076455-10 2017 Multivariate analysis showed that patients with PON1 and CYP2C19 polymorphisms had higher light transmission after ADP aggregometry than patients with native alleles. Adenosine Diphosphate 115-118 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 57-64 27783926-7 2017 In contrast, DSC of the vanadate-trapped MgADP Pgp complex and the MgATP-bound catalytically inactive mutant, E552A/E1197A, show an additional transition at much higher temperature, corresponding to the unfolding of the nucleotide-trapped NBD-dimeric outward-facing conformation. Adenosine Diphosphate 41-46 phosphoglycolate phosphatase Mus musculus 47-50 28631703-6 2017 An association was found between CYP2C19 681A allele carriage and the increased extent of platelet aggregation induced by ADP. Adenosine Diphosphate 122-125 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 33-40 27641736-9 2016 Due to the combined effects of PLA2G7 rs1051931 and rs7756935, carriers of the AA-CC haplotype had a higher level of ADP-induced platelet aggregation, and were at considerably higher risk of aspirin resistance than noncarriers (odds ratio=8.233, 95% CI: 1.590-42.638). Adenosine Diphosphate 117-120 phospholipase A2 group VII Homo sapiens 31-37 27660309-7 2016 The triggers that activate MiD-bound Drp1 in disease states are unknown; however, MiD51 has a unique capacity for ADP binding at its nucleotidyltransferase domain. Adenosine Diphosphate 114-117 mitochondrial elongation factor 1 Homo sapiens 82-87 27660309-8 2016 Without ADP, MiD51 inhibits Drp1, whereas ADP promotes MiD51-mediated fission, suggesting a link between metabolism and fission. Adenosine Diphosphate 42-45 mitochondrial elongation factor 1 Homo sapiens 55-60 27440879-3 2016 The human TARG1/C6orf130, MacroD1, and MacroD2 proteins can reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity of their macro domains. Adenosine Diphosphate 68-71 mono-ADP ribosylhydrolase 2 Homo sapiens 39-46 27440879-3 2016 The human TARG1/C6orf130, MacroD1, and MacroD2 proteins can reverse ADP-ribosylation by acting on ADP-ribosylated substrates through the hydrolytic activity of their macro domains. Adenosine Diphosphate 98-101 mono-ADP ribosylhydrolase 2 Homo sapiens 39-46 27458020-2 2016 The mitochondrial membrane potential (DeltaPsi), a component of Deltap, drives release of mitochondrial ATP(4-) in exchange for cytosolic ADP(3-) via the electrogenic adenine nucleotide translocator (ANT) located in the mitochondrial inner membrane, which leads to a high cytosolic ATP/ADP ratio up to >100-fold greater than matrix ATP/ADP. Adenosine Diphosphate 138-141 seminal vesicle secretory protein 4 Rattus norvegicus 282-289 19118249-10 2009 CONCLUSIONS: RPR to ADP with clopidogrel therapy, measured by the point-of-care assay VerifyNow P2Y12, is able to detect acute coronary syndrome patients at risk of 12-month cardiovascular death and nonfatal MI. Adenosine Diphosphate 20-23 purinergic receptor P2Y12 Homo sapiens 96-101 27618067-2 2016 The second member of the transient receptor potential (TRP) melastatin subfamily, TRPM2, is a Ca(2+)-permeable non-selective cation channel, activated by ROS in an ADP-ribose mediated fashion. Adenosine Diphosphate 164-167 transient receptor potential cation channel subfamily M member 2 Homo sapiens 82-87 19090667-3 2009 Driven under the proton gradients produced by catalysis of GOD microcapsules for glucose, ATP is synthesized from ADP and inorganic phosphate catalyzed by the ATPase rotary catalysis. Adenosine Diphosphate 114-117 dynein axonemal heavy chain 8 Homo sapiens 159-165 27485725-6 2016 It is noteworthy that miR-25 targeting BMPR2 and IRS1, miR-363 targeting USP24, miR-28 targeting HECW2 and miR-210 targeting ATP5I, ME3, MTCH1 and CPT2 were highly associated with slow-twitch oxidative fibers, fast-twitch oxidative fibers, ADP and ATP concentration suggesting an essential role of the miRNA-mRNA regulatory networking in modulating the mitochondrial energy expenditure in the porcine muscle. Adenosine Diphosphate 240-243 carnitine palmitoyltransferase 2 Sus scrofa 147-151 18796009-3 2008 In this study, we describe domain motions in monomeric SKD1 on ATP and ADP binding. Adenosine Diphosphate 71-74 vacuolar protein sorting 4 homolog A Homo sapiens 55-59 18796009-5 2008 Gel filtration and small-angle X-ray scattering experiments showed that the ATP-bound form of SKD1 oligomerizes in solution, whereas ADP-bound and apo forms of SKD1 exist as monomers, even though the conformations of the ADP- and ATP-bound forms are nearly identical. Adenosine Diphosphate 221-224 vacuolar protein sorting 4 homolog A Homo sapiens 94-98 27000416-9 2016 ADP/O ratios for Wt and DN-Trx1 decrease by 25% and 28%, respectively; whereas the Trx1 does not change after ischemia and reperfusion (I/R). Adenosine Diphosphate 0-3 thioredoxin 1 Mus musculus 27-31 18782766-6 2008 Strikingly, assembly of the folding-active GroEL-GroES complex appears to involve a strategic delay in ATP hydrolysis that is coupled to disassembly of the old, ADP-bound GroEL-GroES complex on the opposite ring. Adenosine Diphosphate 161-164 heat shock protein family E (Hsp10) member 1 Homo sapiens 49-54 18782766-6 2008 Strikingly, assembly of the folding-active GroEL-GroES complex appears to involve a strategic delay in ATP hydrolysis that is coupled to disassembly of the old, ADP-bound GroEL-GroES complex on the opposite ring. Adenosine Diphosphate 161-164 heat shock protein family E (Hsp10) member 1 Homo sapiens 177-182 18988745-7 2008 ATP added to the asymmetric GroEL-GroES resting-state complex lacking trans ring ADP is hydrolyzed in the newly formed cis ring with a presteady-state burst of approximately 6 mol of Pi per mole of 14-mer. Adenosine Diphosphate 81-84 heat shock protein family E (Hsp10) member 1 Homo sapiens 34-39 19059569-5 2008 VASP index was calculated from the median fluorescence intensity (MFI) of samples incubated with prostaglandin E1 (PGE1) and adenosine diphosphate according to the formula [(MFI(PGE1)-MFI(PGE1-ADP))/MFI(PGE1)]x100, and was determined at baseline and at days 1 and 4 after starting clopidogrel. Adenosine Diphosphate 125-146 vasodilator stimulated phosphoprotein Homo sapiens 0-4 26976594-8 2016 Thus, the structure reveals the detailed rearrangements underlying myosin force generation as well as the basis of strain-dependent ADP release that is essential for processive myosins, such as myosin V. Adenosine Diphosphate 132-135 myosin VA Homo sapiens 194-202 26911685-11 2016 Nav1.9 transcripts colocalized in 86% of P2Y1-positive and 100% of P2Y2-positive colonic neurons, consistent with reduced afferent fiber responses to UTP and ADP in Na(v)1.9(-/-) mice. Adenosine Diphosphate 158-161 sodium channel, voltage-gated, type XI, alpha Mus musculus 0-6 19160490-5 2008 The aac2(A128P) allele dominantly induces ageing-dependent mitochondrial degeneration and phenotypically tractable degenerative cell death, independently of its ADP/ATP exchange activity. Adenosine Diphosphate 161-164 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 4-8 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 189-210 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 108-116 18471985-7 2008 These results strongly suggest that the ADP-induced phosphorylation of HSP27 via p44/p42 MAPK and/or p38 MAPK is therefore sufficient for platelet granule secretion but not for platelet aggregation in humans. Adenosine Diphosphate 40-43 interferon induced protein 44 Homo sapiens 81-84 26431833-9 2015 The released ATP was sequentially dephosphorylated through ecto-nucleoside triphosphate diphosphohydrolase (NTPDase2) and ecto-5"-nucleotidase/CD73 reactions, with respective generation of adenosine diphosphate (ADP) and adenosine and their maintenance in the extracellular medium at basal levels. Adenosine Diphosphate 212-215 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 108-116 26492236-1 2015 Poly(ADP-ribosyl)ation is known to be involved in a variety of cellular processes, such as DNA repair, cell death, telomere regulation, genomic stability and cell differentiation by poly(ADP-ribose) polymerase (PARP). Adenosine Diphosphate 4-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 182-209 18431598-2 2008 Disruption of SAL1 is synthetically lethal with the loss of a specific function associated with the Aac2 isoform of the ATP/ADP translocase. Adenosine Diphosphate 124-127 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 100-104 18431598-3 2008 This novel activity of Aac2 is defined as the V function (for Viability of aac2 sal1 double mutant), which is independent of the ATP/ADP exchange activity required for respiratory growth (the R function). Adenosine Diphosphate 133-136 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 23-27 26492236-1 2015 Poly(ADP-ribosyl)ation is known to be involved in a variety of cellular processes, such as DNA repair, cell death, telomere regulation, genomic stability and cell differentiation by poly(ADP-ribose) polymerase (PARP). Adenosine Diphosphate 4-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 211-215 26316625-1 2015 Molecules that reduce the level of cyclic adenosine 5"-monophosphate (cAMP) in the platelet cytosol, such as adenosine 5"-diphosphate (ADP) secreted from dense granules, trigger platelet activation. Adenosine Diphosphate 109-133 cathelicidin antimicrobial peptide Mus musculus 35-68 18421459-5 2008 They suggest that Sls1 regulates this interaction, by stimulating the conversion of BiP from the ADP-bound to the ATP-bound state, which favors its interaction with Ire1. Adenosine Diphosphate 97-100 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 165-169 26316625-1 2015 Molecules that reduce the level of cyclic adenosine 5"-monophosphate (cAMP) in the platelet cytosol, such as adenosine 5"-diphosphate (ADP) secreted from dense granules, trigger platelet activation. Adenosine Diphosphate 135-138 cathelicidin antimicrobial peptide Mus musculus 35-68 26140942-5 2015 Direct transport assays with recombinant and reconstituted AtAPC1, AtAPC2 and AtAPC3 showed that they transport phosphate, AMP, ADP, ATP, adenosine 5"-phosphosulfate and, to a lesser extent, other nucleotides. Adenosine Diphosphate 128-131 Mitochondrial substrate carrier family protein Arabidopsis thaliana 59-65 18406329-0 2008 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Adenosine Diphosphate 88-91 H2A.X variant histone Homo sapiens 42-46 26140942-5 2015 Direct transport assays with recombinant and reconstituted AtAPC1, AtAPC2 and AtAPC3 showed that they transport phosphate, AMP, ADP, ATP, adenosine 5"-phosphosulfate and, to a lesser extent, other nucleotides. Adenosine Diphosphate 128-131 Mitochondrial substrate carrier family protein Arabidopsis thaliana 78-84 18201966-5 2008 Unlike previously studied vertebrate myosin Vs, the rate-limiting step in the actomyosin Vc ATPase pathway is the release of inorganic phosphate (~1.5 s(-1)), rather than the ADP release step (~12.0-16.0 s(-1)). Adenosine Diphosphate 175-178 dynein axonemal heavy chain 8 Homo sapiens 92-98 25837286-5 2015 Specifically, in the presence of 0.25 mM ADP, the Mn IC50 was 1.14 +- 0.02 mM and 1.54 +- 0.08 mM for hGDH2 and for hGDH1, respectively (p = 0.0001). Adenosine Diphosphate 41-44 glutamate dehydrogenase 2 Homo sapiens 102-107 25837286-7 2015 At 1 mM ADP, the Mn IC50 was 1.84 +- 0.02 mM and 2.04 +- 0.07 mM (p = 0.01) for hGDH2 and hGDH1, respectively, with 3 mM Mn inhibiting hGDH2 by 93.6% and hGDH1 by 70.9%. Adenosine Diphosphate 8-11 glutamate dehydrogenase 2 Homo sapiens 80-85 25837286-10 2015 These findings, showing an enhanced sensitivity of the hGDH2 isoenzyme to Mn, especially at low ADP levels, might be of pathophysiological relevance under conditions of Mn neurotoxicity. Adenosine Diphosphate 96-99 glutamate dehydrogenase 2 Homo sapiens 55-60 18232657-2 2008 We discovered that modification of natural and synthetic dinucleoside polyphosphates and nucleotides with lipophilic substituents on the ribose and base conferred P2Y12 receptor antagonist properties to these molecules producing potent inhibitors of ADP-mediated platelet aggregation. Adenosine Diphosphate 250-253 purinergic receptor P2Y12 Homo sapiens 163-168 25947062-2 2015 The aim of the current study is to investigate the role of Y311 phosphorylated PKCdelta in regulating ADP-induced platelet activation. Adenosine Diphosphate 102-105 protein kinase C, delta Mus musculus 79-87 25947062-3 2015 In the current study, we employed various inhibitors and murine platelets from mice deficient in specific molecules to evaluate the role of PKCdelta in ADP-induced platelet responses. Adenosine Diphosphate 152-155 protein kinase C, delta Mus musculus 140-148 25947062-8 2015 These results show for the first time that tyrosine phosphorylated PKCdelta regulates ADP-induced thromboxane generation independent of its catalytic activity and that classical PKC isoforms alpha/beta regulate the tyrosine phosphorylation on PKCdelta and subsequent thromboxane generation through tyrosine kinase, Lyn, in platelets. Adenosine Diphosphate 86-89 protein kinase C, delta Mus musculus 67-75 25947062-8 2015 These results show for the first time that tyrosine phosphorylated PKCdelta regulates ADP-induced thromboxane generation independent of its catalytic activity and that classical PKC isoforms alpha/beta regulate the tyrosine phosphorylation on PKCdelta and subsequent thromboxane generation through tyrosine kinase, Lyn, in platelets. Adenosine Diphosphate 86-89 protein kinase C, delta Mus musculus 243-251 18220414-2 2008 We find that K+ or 5-fold lower levels of NH4+ markedly enhanced quenching of Trp383 fluorescence of PDHK2 by ADP and ATP. Adenosine Diphosphate 110-113 pyruvate dehydrogenase kinase 2 Homo sapiens 101-106 18220414-4 2008 Linked reductions in Kd of PDHK2 for K+ were from approximately 30 to approximately 0.75 mM with ATP bound and from approximately 40 to approximately 1.7 mM with ADP bound. Adenosine Diphosphate 162-165 pyruvate dehydrogenase kinase 2 Homo sapiens 27-32 18220414-5 2008 Without K+, there was little effect of ADP on pyruvate binding, but with 100 mM K+ and 100 microM ADP, the L0.5 of PDHK2 for pyruvate was reduced by approximately 14 fold. Adenosine Diphosphate 98-101 pyruvate dehydrogenase kinase 2 Homo sapiens 115-120 18220414-9 2008 We have quantified coupled binding of K+ with ATP and ADP and elucidated how linked K+ and Pi binding are required for the potent inhibition of PDHK2 by ADP and pyruvate. Adenosine Diphosphate 54-57 pyruvate dehydrogenase kinase 2 Homo sapiens 144-149 18220414-9 2008 We have quantified coupled binding of K+ with ATP and ADP and elucidated how linked K+ and Pi binding are required for the potent inhibition of PDHK2 by ADP and pyruvate. Adenosine Diphosphate 153-156 pyruvate dehydrogenase kinase 2 Homo sapiens 144-149 18220415-3 2008 With 50 mM K+, Pi enhanced interference by ADP, ATP, or pyruvate of PDHK2 binding to GST-L2. Adenosine Diphosphate 43-46 pyruvate dehydrogenase kinase 2 Homo sapiens 68-73 18220415-4 2008 The inclusion of Pi with ADP or ATP plus pyruvate greatly hindered PDHK2 binding to GST-L2 and promoted PDHK2 forming a tetramer. Adenosine Diphosphate 25-28 pyruvate dehydrogenase kinase 2 Homo sapiens 67-72 18220415-4 2008 The inclusion of Pi with ADP or ATP plus pyruvate greatly hindered PDHK2 binding to GST-L2 and promoted PDHK2 forming a tetramer. Adenosine Diphosphate 25-28 pyruvate dehydrogenase kinase 2 Homo sapiens 104-109 25947062-8 2015 These results show for the first time that tyrosine phosphorylated PKCdelta regulates ADP-induced thromboxane generation independent of its catalytic activity and that classical PKC isoforms alpha/beta regulate the tyrosine phosphorylation on PKCdelta and subsequent thromboxane generation through tyrosine kinase, Lyn, in platelets. Adenosine Diphosphate 86-89 LYN proto-oncogene, Src family tyrosine kinase Mus musculus 315-318 26249166-4 2015 Erythrocytes from Ampd3(-/-) mice exhibited higher half-saturation pressure of oxygen (p50) and about 3-fold higher levels of ATP and ADP, while they maintained normal 2,3-bisphosphoglycerate (2,3-BPG), methemoglobin levels and intracellular pH. Adenosine Diphosphate 134-137 adenosine monophosphate deaminase 3 Mus musculus 18-23 25824297-4 2015 In response to H/R injury, the decrease in CXCR4 expression was associated with dysfunctional energy metabolism indicated by an increased adenosine diphosphate/adenosine triphosphate (ADP/ATP) ratio. Adenosine Diphosphate 138-159 C-X-C motif chemokine receptor 4 Rattus norvegicus 43-48 25824297-4 2015 In response to H/R injury, the decrease in CXCR4 expression was associated with dysfunctional energy metabolism indicated by an increased adenosine diphosphate/adenosine triphosphate (ADP/ATP) ratio. Adenosine Diphosphate 184-187 C-X-C motif chemokine receptor 4 Rattus norvegicus 43-48 25864199-5 2015 This variant resembled the ADP-bound conformer at all times yet remained able to interact with cofactors, nucleotides, and substrates appropriately, resembling a dominant negative Hsc70 (DN-Hsc70). Adenosine Diphosphate 27-30 heat shock protein family A (Hsp70) member 8 Homo sapiens 180-185 25864199-5 2015 This variant resembled the ADP-bound conformer at all times yet remained able to interact with cofactors, nucleotides, and substrates appropriately, resembling a dominant negative Hsc70 (DN-Hsc70). Adenosine Diphosphate 27-30 heat shock protein family A (Hsp70) member 8 Homo sapiens 190-195 25941405-9 2015 Using nucleotide binding and hydrolysis mutants, we show that, although ATP exerts its effects via binding AAA1, ADP effects are mediated by AAA3. Adenosine Diphosphate 113-116 AAA1 Homo sapiens 107-111 25941405-9 2015 Using nucleotide binding and hydrolysis mutants, we show that, although ATP exerts its effects via binding AAA1, ADP effects are mediated by AAA3. Adenosine Diphosphate 113-116 AAA3 Homo sapiens 141-145 26913285-2 2015 The Hsp70 folding cycle is driven by two types of cochaperones: J-domain proteins stimulate ATP hydrolysis by Hsp70, while nucleotide exchange factors (NEFs) promote replacement of Hsp70-bound ADP with ATP. Adenosine Diphosphate 193-196 hypoxia up-regulated 1 Homo sapiens 4-9 25785436-3 2015 The SPL/RGS/SHP-1 complex is present in resting platelets, dissociating when thrombin or TxA2, but not ADP or collagen, activate SHP-1 and release RGS10 and RGS18 to dampen signaling. Adenosine Diphosphate 103-106 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 12-17 25404741-7 2015 They also showed an aggregation defect that could be rescued with exogenous ADP and increased embolization in Stx8(-/-) mice in vivo consistent with an important autocrine and paracrine role for ADP in aggregation and thrombus stabilization. Adenosine Diphosphate 195-198 syntaxin 8 Mus musculus 110-114 25372046-5 2015 NTPDase3 and -8 yield AMP and ADP, while NTPDase2 results mainly in the formation of ADP. Adenosine Diphosphate 85-88 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 41-49 25362066-2 2015 strain ADP, AtzF, provides the final hydrolytic step for the mineralization of s-triazines, such as atrazine and cyanuric acid. Adenosine Diphosphate 7-10 atzF Pseudomonas sp. ADP 12-16 25129381-9 2015 Furthermore, we found that ADP potentiates TCDD action, which led to the discovery that ADP itself activates AHR in the absence of TCDD. Adenosine Diphosphate 27-30 aryl hydrocarbon receptor 1a Danio rerio 109-112 25129381-9 2015 Furthermore, we found that ADP potentiates TCDD action, which led to the discovery that ADP itself activates AHR in the absence of TCDD. Adenosine Diphosphate 88-91 aryl hydrocarbon receptor 1a Danio rerio 109-112 25129381-10 2015 Taken together, these results resolved the pathway of TCDD activation of thrombocytes and led to the finding that ADP is an activator of AHR. Adenosine Diphosphate 114-117 aryl hydrocarbon receptor 1a Danio rerio 137-140 25311974-8 2015 Adenosine diphosphate-induced platelet aggregation was significantly inhibited at 4 and 24 h after administration of clopidogrel in the CYP2C19 EM group. Adenosine Diphosphate 0-21 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 136-143 25487014-3 2015 The ATPase activity of Hsp70 is regulated by two main classes of cochaperones: J-domain proteins stimulate ATPase hydrolysis by Hsp70, while nucleotide exchange factors (NEF) facilitate its conversion from the ADP-bound to the ATP-bound state, thus closing the chaperone folding cycle. Adenosine Diphosphate 210-213 heat shock protein family A (Hsp70) member 4 Homo sapiens 23-28 25487014-3 2015 The ATPase activity of Hsp70 is regulated by two main classes of cochaperones: J-domain proteins stimulate ATPase hydrolysis by Hsp70, while nucleotide exchange factors (NEF) facilitate its conversion from the ADP-bound to the ATP-bound state, thus closing the chaperone folding cycle. Adenosine Diphosphate 210-213 heat shock protein family A (Hsp70) member 4 Homo sapiens 128-133 25545246-5 2014 Synphilin-1 was pulled down by ATP-agarose beads, and the addition of ATP and ADP reduced this binding, indicating that synphilin-1 bound ADP and ATP. Adenosine Diphosphate 78-81 synuclein alpha interacting protein Homo sapiens 0-11 25545246-5 2014 Synphilin-1 was pulled down by ATP-agarose beads, and the addition of ATP and ADP reduced this binding, indicating that synphilin-1 bound ADP and ATP. Adenosine Diphosphate 78-81 synuclein alpha interacting protein Homo sapiens 120-131 25545246-5 2014 Synphilin-1 was pulled down by ATP-agarose beads, and the addition of ATP and ADP reduced this binding, indicating that synphilin-1 bound ADP and ATP. Adenosine Diphosphate 138-141 synuclein alpha interacting protein Homo sapiens 0-11 17214996-6 2008 Inhibition of the platelet ADP P2Y12 receptor by clopidogrel was monitored by the ex vivo analysis of ADP effects on prostaglandin-induced platelet VASP phosphorylation. Adenosine Diphosphate 27-30 vasodilator stimulated phosphoprotein Homo sapiens 148-152 19095614-8 2008 The ETP of FVIII- and FIX-deficient plasma, but not FVII-depleted plasma, improved significantly upon addition of washed normal platelets or washed normal platelets with ADP. Adenosine Diphosphate 170-173 coagulation factor VIII Homo sapiens 11-16 25545246-5 2014 Synphilin-1 was pulled down by ATP-agarose beads, and the addition of ATP and ADP reduced this binding, indicating that synphilin-1 bound ADP and ATP. Adenosine Diphosphate 138-141 synuclein alpha interacting protein Homo sapiens 120-131 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 77-98 dual specificity phosphatase 2 Homo sapiens 154-159 25208846-6 2014 However, in mice lacking ectonucleotidases Entpd1 (ATP ADP AMP) or Nt5e (AMP adenosine), or by inhibiting adenosine signaling, the refractory response was altered, resulting in repeated BSM contractions in response to repeated ADP (0.1-1 mM) stimulation. Adenosine Diphosphate 55-58 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 43-49 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 100-103 dual specificity phosphatase 2 Homo sapiens 154-159 25208846-7 2014 Our data indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1/Nt5e activity and adenosine receptors; and ADP-adenosine signaling play an important role in modulating P2X-mediated BSM contraction. Adenosine Diphosphate 62-65 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 106-112 18495218-1 2008 ADP plays a key role in platelet aggregation which has led to the development of antiplatelet drugs that target the P2Y12 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 116-121 25362487-2 2014 Here we report cryo-EM structures for ADP-bound and ADP-beryllium fluoride (ADP-BeFx, an ADP-Pi mimic)-bound actin filaments in complex with the beta-propeller domain of yeast coronin 1 (crn1), at 8.6-A resolution. Adenosine Diphosphate 38-41 Crn1p Saccharomyces cerevisiae S288C 176-185 18539312-2 2008 The key role that ADP plays in this process has led to the development of antiplatelet drugs that target the P2Y12 receptor. Adenosine Diphosphate 18-21 purinergic receptor P2Y12 Homo sapiens 109-114 25362487-2 2014 Here we report cryo-EM structures for ADP-bound and ADP-beryllium fluoride (ADP-BeFx, an ADP-Pi mimic)-bound actin filaments in complex with the beta-propeller domain of yeast coronin 1 (crn1), at 8.6-A resolution. Adenosine Diphosphate 52-55 Crn1p Saccharomyces cerevisiae S288C 176-185 25362487-2 2014 Here we report cryo-EM structures for ADP-bound and ADP-beryllium fluoride (ADP-BeFx, an ADP-Pi mimic)-bound actin filaments in complex with the beta-propeller domain of yeast coronin 1 (crn1), at 8.6-A resolution. Adenosine Diphosphate 52-55 Crn1p Saccharomyces cerevisiae S288C 187-191 24865146-4 2014 Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation. Adenosine Diphosphate 116-119 mono-ADP ribosylhydrolase 2 Homo sapiens 54-61 24865146-4 2014 Hydrolytic activity of macrodomain proteins (MacroD1, MacroD2 and TARG1) is responsible for the removal of terminal ADP-ribose unit and for complete reversion of protein ADP-ribosylation. Adenosine Diphosphate 170-173 mono-ADP ribosylhydrolase 2 Homo sapiens 54-61 24894903-9 2014 The isolates carrying allele having amino acid substitution inside the highly ATP/ADP or Mg(2+)-binding region could not tolerate thermal stress and showed lower expression of the groEL gene. Adenosine Diphosphate 82-85 heat shock protein family D (Hsp60) member 1 Homo sapiens 180-185 25265076-9 2014 RAL-treated individuals showed significantly lower P-selectin expression to stimulation with low (P = 0.026 vs. NNRTI and P = 0.005 vs. protease inhibitor group) and high-dose ADP (P = 0.009 vs. NNRTI and P = 0.003 vs. protease inhibitor group). Adenosine Diphosphate 176-179 RAS like proto-oncogene A Homo sapiens 0-3 17976642-1 2007 GrpE acts as a nucleotide exchange factor for DnaK, the main Hsp70 protein in bacteria, accelerating ADP/ATP exchange by several orders of magnitude. Adenosine Diphosphate 101-104 GrpE like 1, mitochondrial Homo sapiens 0-4 17976642-7 2007 Partial proteolysis and substrate dissociation kinetics also suggest that the N-terminal half of GrpE coils (residues 34-68) interacts with DnaK interdomain linker, regulates the nucleotide exchange activity of the cochaperone and is required to stabilize DnaK-substrate complexes in the ADP-bound conformation. Adenosine Diphosphate 288-291 GrpE like 1, mitochondrial Homo sapiens 97-101 17641217-4 2007 K(ATP) channel heteromultimers consist of inwardly-rectifying K(+) channel 6.2 and ATP-binding cassette sulfonylurea receptor 2A that translates local ATP/ADP levels, set by ATPases and phosphotransfer reactions, to the channel pore function. Adenosine Diphosphate 155-158 ATP binding cassette subfamily C member 9 Homo sapiens 104-127 17803810-2 2007 The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. Adenosine Diphosphate 122-143 purinergic receptor P2Y12 Homo sapiens 24-29 17803810-2 2007 The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. Adenosine Diphosphate 122-143 purinergic receptor P2Y12 Homo sapiens 45-51 17803810-2 2007 The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. Adenosine Diphosphate 145-148 purinergic receptor P2Y12 Homo sapiens 24-29 17803810-2 2007 The H2 haplotype of the P2Y12 receptor gene (P2RY12) has been found to be associated with maximal aggregation response to adenosine diphosphate (ADP) and with increased risk for peripheral arterial disease. Adenosine Diphosphate 145-148 purinergic receptor P2Y12 Homo sapiens 45-51 17767906-7 2007 ADP may elicit these anti-adipogenic functions by regulating chromatin dynamics and gene transcription, as it binds both histones and HDAC3 and inhibits PPARgamma activity. Adenosine Diphosphate 0-3 peroxisome proliferator activated receptor gamma Mus musculus 153-162 17340632-7 2007 Furthermore, TopBP1 was detected in nuclear regions where poly(ADP-ribose) (PAR) synthesis takes place and is ADP-ribosylated by PARP-1. Adenosine Diphosphate 63-66 DNA topoisomerase II binding protein 1 Homo sapiens 13-19 17551507-7 2007 These results demonstrate that Ad5-yCD/mutTK(SR39)rep-ADP-mediated suicide gene therapy has the potential to augment the effectiveness of pancreatic radiotherapy without resulting in excessive toxicity. Adenosine Diphosphate 54-57 Alzheimer disease, familial, type 5 Homo sapiens 31-34 17572439-2 2007 Here we show by differential tagging that the yeast mitochondrial ADP/ATP carrier AAC2 is a monomer in mild detergents. Adenosine Diphosphate 66-69 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 82-86 17490600-4 2007 ADP production is concomitant with Raf-mediated phosphorylation of MEK. Adenosine Diphosphate 0-3 zinc fingers and homeoboxes 2 Homo sapiens 35-38 17412886-3 2007 For patients in advanced phase (AdP), a higher expression of both PR3 and ELA2 in CD34(+) progenitors before SCT was associated with a lower incidence of relapse-related death, improved leukemia-free survival (LFS), and overall survival (OS); in chronic phase patients, no differences were observed. Adenosine Diphosphate 32-35 proteinase 3 Homo sapiens 66-69 17412886-3 2007 For patients in advanced phase (AdP), a higher expression of both PR3 and ELA2 in CD34(+) progenitors before SCT was associated with a lower incidence of relapse-related death, improved leukemia-free survival (LFS), and overall survival (OS); in chronic phase patients, no differences were observed. Adenosine Diphosphate 32-35 elastase, neutrophil expressed Homo sapiens 74-78 17561960-14 2007 In contrast, both MgADP and beryllium fluoride inhibited the ATPase activity of the nucleotide-binding domains. Adenosine Diphosphate 18-23 dynein axonemal heavy chain 8 Homo sapiens 61-67 17110146-4 2007 ADP initiates platelet aggregation by "simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Bos taurus 99-103 17110146-11 2007 Subsequently the structural model of P2Y12 was docked with ATP/ADP in comparison with P2Y1 (PDB code 1ddd). Adenosine Diphosphate 63-66 purinergic receptor P2Y1 Bos taurus 37-41 17566106-3 2007 Here, we show by negative dominance studies that the yeast mitochondrial ADP/ATP carrier 2 from Saccharomyces cerevisiae (AAC2) is functional as a monomer in the mitochondrial membrane. Adenosine Diphosphate 73-76 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 122-126 17510632-4 2007 Here, we demonstrate that myosin VI gating is achieved instead by blocking ATP binding to the lead head once it has released its ADP. Adenosine Diphosphate 129-132 myosin VI Homo sapiens 26-35 17510632-6 2007 Reverse strain greatly favors binding of ADP to the lead head, which makes it possible for myosin VI to function as a processive transporter as well as an actin-based anchor. Adenosine Diphosphate 41-44 myosin VI Homo sapiens 91-100 17547762-7 2007 Patients with high platelet expression of FcGammaRIIA exhibited 3-fold greater platelet reactivity compared with that in those with low expression in response to convulxin (p < 0.01) and 2-fold greater activation in response to thrombin, ADP, and PAF (p < 0.05 for each). Adenosine Diphosphate 241-244 Fc gamma receptor IIa Homo sapiens 42-53 17298299-1 2007 We have previously shown that ADP-induced thromboxane generation in platelets requires signalling events from the G(q)-coupled P2Y1 receptor (platelet ADP receptor coupled to stimulation of phospholipase C) and the G(i)-coupled P2Y12 receptor (platelet ADP receptor coupled to inhibition of adenylate cyclase) in addition to outside-in signalling. Adenosine Diphosphate 30-33 purinergic receptor P2Y12 Homo sapiens 228-233 17298299-5 2007 However, blockade of either P2Y1 or the P2Y12 receptors with corresponding antagonists completely abolished ERK phosphorylation, indicating that both P2Y receptors are required for ADP-induced ERK activation. Adenosine Diphosphate 181-184 purinergic receptor P2Y12 Homo sapiens 40-45 17521334-7 2007 ADP has the same effect, in contrast to the nonhydrolyzable analog adenosine 5"-(beta,gamma-imido)triphosphate, indicating that in order to inhibit iron regulatory protein-1 binding activity, ATP must be hydrolyzed. Adenosine Diphosphate 0-3 aconitase 1 Homo sapiens 148-173 17310282-3 2007 The E2-enhanced activity of the widely distributed PDK2 is limited by dissociation of ADP from its C-terminal catalytic domain, and this is further slowed by pyruvate binding to the N-terminal regulatory (R) domain. Adenosine Diphosphate 86-89 pyruvate dehydrogenase kinase 2 Homo sapiens 51-55 17310282-4 2007 Via the reverse of the PDC reaction, NADH and acetyl-CoA reductively acetylate lipoyl group of L2, which binds to the R domain and stimulates PDK2 activity by speeding up ADP dissociation. Adenosine Diphosphate 171-174 pyruvate dehydrogenase kinase 2 Homo sapiens 142-146 17327453-6 2007 Omission of the nucleotide resulted in rapid loss of PIP(2) with t(1/2) < 40 s. ADP also stimulated PIP(2) formation, but this effect reflected local ATP formation and was prevented by the adenylate kinase inhibitor diadenosine-pentaphosphate. Adenosine Diphosphate 83-86 prolactin induced protein Mus musculus 53-56 17327453-6 2007 Omission of the nucleotide resulted in rapid loss of PIP(2) with t(1/2) < 40 s. ADP also stimulated PIP(2) formation, but this effect reflected local ATP formation and was prevented by the adenylate kinase inhibitor diadenosine-pentaphosphate. Adenosine Diphosphate 83-86 prolactin induced protein Mus musculus 103-106 17327453-7 2007 The ATP-induced PIP(2) synthesis was counteracted by the ADP analog adenosine-5"-O-2-thiodiphosphate. Adenosine Diphosphate 57-60 prolactin induced protein Mus musculus 16-19 17327453-8 2007 We conclude that plasma membrane PIP(2) is dynamically regulated by intracellular Ca(2+) and the ATP-to-ADP ratio in insulin-secreting cells. Adenosine Diphosphate 104-107 prolactin induced protein Mus musculus 33-36 17167068-7 2007 However, ADP responses were significantly enhanced in the presence of the ENT1 nucleoside transporter inhibitors dipyridamole and NBTI and were significantly inhibited by adenosine deaminase, indicating a role for extracellular adenosine. Adenosine Diphosphate 9-12 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 74-78 16990590-4 2007 Here, we show that ADP secreted from platelet-dense granules, and subsequent activation of P2Y12 receptors, as well as TxA2 release are important upstream mediators of p38 MAP kinase activation by thrombin. Adenosine Diphosphate 19-22 purinergic receptor P2Y12 Homo sapiens 91-96 17187456-1 2007 Platelets possess three P2 receptors for adenine nucleotides: P2Y1 and P2Y12, which interact with ADP, and P2X1, which interacts with ATP. Adenosine Diphosphate 98-101 purinergic receptor P2Y12 Homo sapiens 71-76 17567608-5 2007 Experiments with Rad51-K191R as well as with wild-type Rad51-dsDNA filaments formed in the presence of ATP, ADP or ATP-gamma-S showed that efficient Rad51 turnover from dsDNA requires both the Rad51 ATPase and the Rad54 ATPase activities. Adenosine Diphosphate 108-111 recombinase RAD51 Saccharomyces cerevisiae S288C 55-60 17567608-5 2007 Experiments with Rad51-K191R as well as with wild-type Rad51-dsDNA filaments formed in the presence of ATP, ADP or ATP-gamma-S showed that efficient Rad51 turnover from dsDNA requires both the Rad51 ATPase and the Rad54 ATPase activities. Adenosine Diphosphate 108-111 recombinase RAD51 Saccharomyces cerevisiae S288C 55-60 17567608-5 2007 Experiments with Rad51-K191R as well as with wild-type Rad51-dsDNA filaments formed in the presence of ATP, ADP or ATP-gamma-S showed that efficient Rad51 turnover from dsDNA requires both the Rad51 ATPase and the Rad54 ATPase activities. Adenosine Diphosphate 108-111 recombinase RAD51 Saccharomyces cerevisiae S288C 55-60 16563469-1 2007 INTRODUCTION: Clopidogrel inhibits platelet P2Y12 ADP receptors, while ADP, as an inductor of aggregation, stimulates both P2Y12 and P2Y1 platelet receptors. Adenosine Diphosphate 50-53 purinergic receptor P2Y12 Homo sapiens 44-49 16563469-4 2007 ADP is used to maximally activate the platelets by binding to the P2Y1 and P2Y12 platelet receptors, while PGE1 is used to suppress the ADP-induced P2Y1-mediated increase in intracellular calcium levels. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 75-80 17239427-7 2007 SDF-1 could enhance low-dose ADP induced platelet aggregation, although it failed by itself to induce aggregation. Adenosine Diphosphate 29-32 C-X-C motif chemokine ligand 12 Homo sapiens 0-5 17135353-1 2006 The chaperonin GroEL-GroES, a machine that helps proteins to fold, cycles through a number of allosteric states, the T state, with high affinity for substrate proteins, the ATP-bound R state, and the R" (GroEL-ADP-GroES) complex. Adenosine Diphosphate 210-213 heat shock protein family E (Hsp10) member 1 Homo sapiens 21-26 17135353-1 2006 The chaperonin GroEL-GroES, a machine that helps proteins to fold, cycles through a number of allosteric states, the T state, with high affinity for substrate proteins, the ATP-bound R state, and the R" (GroEL-ADP-GroES) complex. Adenosine Diphosphate 210-213 heat shock protein family E (Hsp10) member 1 Homo sapiens 214-219 17111196-1 2006 BACKGROUND: P2Y12 is the major platelet receptor that mediates ADP-induced aggregation. Adenosine Diphosphate 63-66 purinergic receptor P2Y12 Homo sapiens 12-17 17139371-3 2006 The platelet reactivity index (PRI) of VASP was calculated both from mean fluorescence intensity (MFI) and percent of fluorescence-positive platelets in the presence of PGE1 with or without ADP (10 microM). Adenosine Diphosphate 190-193 vasodilator stimulated phosphoprotein Homo sapiens 39-43 17139371-11 2006 These six subjects showed the lowest ADP EC50 values in the absence of the drug, possibly reflecting high sensitivity of their platelet P2Y12 receptors to ADP. Adenosine Diphosphate 37-40 purinergic receptor P2Y12 Homo sapiens 136-141 17139371-11 2006 These six subjects showed the lowest ADP EC50 values in the absence of the drug, possibly reflecting high sensitivity of their platelet P2Y12 receptors to ADP. Adenosine Diphosphate 155-158 purinergic receptor P2Y12 Homo sapiens 136-141 17059469-5 2006 ADP acts through two G protein-coupled receptors, the Gq-coupled P2Y1 receptor, and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 99-104 17059469-9 2006 Furthermore, costimulation of both P2Y1 and P2Y12 receptors is required for ADP-induced platelet aggregation. Adenosine Diphosphate 76-79 purinergic receptor P2Y12 Homo sapiens 44-49 16934758-0 2006 Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Adenosine Diphosphate 50-53 purinergic receptor P2Y12 Homo sapiens 74-79 16963786-5 2006 Upon complex formation with co-chaperonin GroES in the presence of ADP, Tyr478 exhibits two peaks that would originate from the cis and trans rings of the asymmetric GroEL-GroES complex. Adenosine Diphosphate 67-70 heat shock protein family E (Hsp10) member 1 Homo sapiens 42-47 16963786-5 2006 Upon complex formation with co-chaperonin GroES in the presence of ADP, Tyr478 exhibits two peaks that would originate from the cis and trans rings of the asymmetric GroEL-GroES complex. Adenosine Diphosphate 67-70 heat shock protein family E (Hsp10) member 1 Homo sapiens 172-177 16605250-10 2006 A partial displacement of the active-site zinc in the FDH.ADP-ribose binary complex indicates that the disruption of the interaction between Glu-67 and Arg-368 is involved in the displacement of active-site zinc. Adenosine Diphosphate 58-61 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 54-57 16551937-4 2006 Storage temperature of 22 degrees C exclusively enhanced adenosine diphosphate- and collagen-induced aggregation compared with storage at 37 degrees C. The binding of PAC-1 was enhanced at test temperatures below 37 degrees C. Prewarming the antibody above 22 degrees C significantly decreased binding. Adenosine Diphosphate 57-78 dual specificity phosphatase 2 Homo sapiens 167-172 16339499-1 2006 OBJECTIVE: ADP-induced P2y12 signaling is crucial for formation and stabilization of an arterial thrombus. Adenosine Diphosphate 11-14 purinergic receptor P2Y12 Homo sapiens 23-28 16081692-6 2005 PECAM-1-/- platelets displayed normal platelet alpha granule secretion, normal platelet aggregation to protease-activated receptor-4 (PAR-4), adenosine diphosphate (ADP), and calcium ionophore, and static platelet adhesion. Adenosine Diphosphate 142-163 platelet/endothelial cell adhesion molecule 1 Mus musculus 0-7 16081692-6 2005 PECAM-1-/- platelets displayed normal platelet alpha granule secretion, normal platelet aggregation to protease-activated receptor-4 (PAR-4), adenosine diphosphate (ADP), and calcium ionophore, and static platelet adhesion. Adenosine Diphosphate 165-168 platelet/endothelial cell adhesion molecule 1 Mus musculus 0-7 16228296-6 2005 Since it is known that ADP stimulates the PI3K and calcium signal primarily through P2Y12 and P2Y1 receptors respectively, our data indicated that integrin alpha(IIb)beta3 downstream PI3K and calcium activation might be not completely coupled to integrin associated signaling complex, but in part through feedback stimulation by granular released ADP. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 84-89 16236603-1 2005 ADP activates human platelets through two G-protein coupled receptors, P2Y1 and P2Y12, to induce a range of functional responses. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 80-85 16236603-2 2005 Here we have addressed the role and mechanism of P2Y12 in modulating ADP-induced platelet shape change. Adenosine Diphosphate 69-72 purinergic receptor P2Y12 Homo sapiens 49-54 16236603-7 2005 We conclude that P2Y12 plays a potentiatory role in ADP-induced shape change through regulation of the Rho kinase pathway, potentiating both myosin phosphorylation and actin polymerisation, and this forms part of an important signalling pathway additional to its well-established Gi-coupled pathways. Adenosine Diphosphate 52-55 purinergic receptor P2Y12 Homo sapiens 17-22 16025128-4 2005 CAG-hairpin binding inhibits the ATPase activity of Msh2-Msh3 and alters both nucleotide (ADP and ATP) affinity and binding interfaces between protein and DNA. Adenosine Diphosphate 90-93 mutS homolog 2 Homo sapiens 52-56 16025128-4 2005 CAG-hairpin binding inhibits the ATPase activity of Msh2-Msh3 and alters both nucleotide (ADP and ATP) affinity and binding interfaces between protein and DNA. Adenosine Diphosphate 90-93 mutS homolog 3 Homo sapiens 57-61 15996167-3 2005 This study was conducted to investigate the association of HLA-DQA1, -DQB1 allele polymorphisms with an autoantibody against the myocardial mitochondria ADP/ATP carrier, and to explore susceptibility to idiopathic dilated cardiomyopathy (IDC) among the Han ethnic group in northern China and the immunological mechanisms and hereditary susceptibility to IDC. Adenosine Diphosphate 153-156 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 59-67 15705797-7 2005 Platelets lacking PI3Kgamma disaggregated following low-dose adenosine diphosphate (ADP) and had a mildly impaired ability to mobilize intracellular calcium. Adenosine Diphosphate 61-82 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 18-27 15705797-7 2005 Platelets lacking PI3Kgamma disaggregated following low-dose adenosine diphosphate (ADP) and had a mildly impaired ability to mobilize intracellular calcium. Adenosine Diphosphate 84-87 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 18-27 16008568-4 2005 Crystallization of Rio1 in the presence of ATP or ADP and manganese ions demonstrated major conformational changes in the active site, compared with the uncomplexed protein. Adenosine Diphosphate 50-53 protein kinase RIO1 Saccharomyces cerevisiae S288C 19-23 15863506-11 2005 In ADP-stimulated platelets, Rap1B activation was reduced, although not abolished, upon blockade of the P2Y1 receptor. Adenosine Diphosphate 3-6 RAP1B, member of RAS oncogene family Homo sapiens 29-34 15863506-12 2005 However, accumulation of GTP-bound Rap1B in platelets activated by co-stimulation of cMpl and P2Y12 receptor was identical to that induced by the simultaneous ligation of P2Y1 and P2Y12 receptor by ADP. Adenosine Diphosphate 198-201 purinergic receptor P2Y12 Homo sapiens 180-185 15978900-4 2005 SUR increases the open probability of K(ATP) channels by interacting with ATP and ADP through NBDs and with K(+) channel openers such as nicorandil through its transmembrane domain. Adenosine Diphosphate 82-85 ATP binding cassette subfamily C member 8 Homo sapiens 0-3 18404504-9 2005 Various NTPDases may also distinctly affect formation of extracellular adenosine and therefore adenosine receptor-mediated responses, since they generate different amounts of the substrate (AMP) and inhibitor (ADP) of ecto-5"-nucleotidase, the rate limiting enzyme in the production of adenosine. Adenosine Diphosphate 210-213 5'-nucleotidase ecto Homo sapiens 218-238 15320873-0 2005 A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Adenosine Diphosphate 47-50 translocation channel protein TIM22 Saccharomyces cerevisiae S288C 88-93 15320873-1 2005 The yeast ADP/ATP carrier (AAC) is a mitochondrial protein that is targeted to the inner membrane via the TIM10 and TIM22 translocase complexes. Adenosine Diphosphate 10-13 translocation channel protein TIM22 Saccharomyces cerevisiae S288C 116-121 15585580-5 2004 The structures reveal a unique spatial arrangement of the two conserved helicase domains, and ADP-binding induces significant conformational changes of key residues in the ATP-binding pocket. Adenosine Diphosphate 94-97 helicase for meiosis 1 Homo sapiens 72-80 15319286-4 2004 Intravascular nucleotides released by inflammatory cells undergo phosphohydrolysis via hypoxia-induced CD39 ectoapyrase (CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5"-nucleotidase (CD73 converts AMP to adenosine). Adenosine Diphosphate 185-188 5'-nucleotidase ecto Homo sapiens 228-232 15319286-4 2004 Intravascular nucleotides released by inflammatory cells undergo phosphohydrolysis via hypoxia-induced CD39 ectoapyrase (CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5"-nucleotidase (CD73 converts AMP to adenosine). Adenosine Diphosphate 185-188 5'-nucleotidase ecto Homo sapiens 255-259 15581845-0 2004 Ca2+ binding to sarcoplasmic reticulum ATPase phosphorylated by Pi reveals four thapsigargin-sensitive Ca2+ sites in the presence of ADP. Adenosine Diphosphate 133-136 dynein axonemal heavy chain 8 Homo sapiens 39-45 15581845-8 2004 These findings indicate that more than two functional Ca2+-sites exist on the functional Ca2+-ATPase unit, and that the additional sites become accessible upon ADP addition. Adenosine Diphosphate 160-163 dynein axonemal heavy chain 8 Homo sapiens 94-100 18404401-2 2004 We postulated that the endothelial P2Y(1) receptor that release vasodilatory factors in response to ADP might play a vital role in the regulation of coronary flow. Adenosine Diphosphate 100-103 purinergic receptor P2Y1 Sus scrofa 35-50 18404401-12 2004 Thus, ADP acting on the endothelial P2Y(1) receptor may play a major role in coronary flow during post-ischemic hyperemia. Adenosine Diphosphate 6-9 purinergic receptor P2Y1 Sus scrofa 36-51 15347676-0 2004 Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. Adenosine Diphosphate 41-44 nudix hydrolase 9 Homo sapiens 13-18 15491150-2 2004 With E2-activated PDK2, K(+) at approximately 90 mM and Cl(-) at approximately 60 mM decreased the K(m) of PDK2 for ATP and competitive K(i) for ADP by approximately 3-fold and enhanced pyruvate inhibition. Adenosine Diphosphate 145-148 pyruvate dehydrogenase kinase 2 Homo sapiens 18-22 15491150-2 2004 With E2-activated PDK2, K(+) at approximately 90 mM and Cl(-) at approximately 60 mM decreased the K(m) of PDK2 for ATP and competitive K(i) for ADP by approximately 3-fold and enhanced pyruvate inhibition. Adenosine Diphosphate 145-148 pyruvate dehydrogenase kinase 2 Homo sapiens 107-111 15491150-5 2004 During E2-aided catalysis, PDK2 had approximately 3 times more ADP than ATP bound at its active site, and the pyruvate analogue, dichloroacetate, led to 16-fold more ADP than ATP being bound (no added ADP). Adenosine Diphosphate 63-66 pyruvate dehydrogenase kinase 2 Homo sapiens 27-31 15491150-5 2004 During E2-aided catalysis, PDK2 had approximately 3 times more ADP than ATP bound at its active site, and the pyruvate analogue, dichloroacetate, led to 16-fold more ADP than ATP being bound (no added ADP). Adenosine Diphosphate 166-169 pyruvate dehydrogenase kinase 2 Homo sapiens 27-31 15491150-5 2004 During E2-aided catalysis, PDK2 had approximately 3 times more ADP than ATP bound at its active site, and the pyruvate analogue, dichloroacetate, led to 16-fold more ADP than ATP being bound (no added ADP). Adenosine Diphosphate 166-169 pyruvate dehydrogenase kinase 2 Homo sapiens 27-31 15491150-8 2004 Our results indicate that, at physiological salt levels, ADP dissociation is a limiting step in E2-activated PDK2 catalysis, that PDK2. Adenosine Diphosphate 57-60 pyruvate dehydrogenase kinase 2 Homo sapiens 109-113 15491150-8 2004 Our results indicate that, at physiological salt levels, ADP dissociation is a limiting step in E2-activated PDK2 catalysis, that PDK2. Adenosine Diphosphate 57-60 pyruvate dehydrogenase kinase 2 Homo sapiens 130-134 15491150-9 2004 [ADP or ATP].pyruvate complexes form, and that PDK2.ATP.pyruvate.E1 reacts with PDK2.ADP.pyruvate accumulating. Adenosine Diphosphate 1-4 pyruvate dehydrogenase kinase 2 Homo sapiens 47-51 15491150-9 2004 [ADP or ATP].pyruvate complexes form, and that PDK2.ATP.pyruvate.E1 reacts with PDK2.ADP.pyruvate accumulating. Adenosine Diphosphate 1-4 pyruvate dehydrogenase kinase 2 Homo sapiens 80-84 15491151-5 2004 Stimulation of PDK2 activity greatly reduced the fraction of bound ADP. Adenosine Diphosphate 67-70 pyruvate dehydrogenase kinase 2 Homo sapiens 15-19 15389120-2 2004 Apyrase (CD39) takes part of a family of ecto-enzymes that hydrolyze adenosine diphosphate and adenosine triphosphate. Adenosine Diphosphate 69-90 apyrase Solanum tuberosum 0-7 17191791-2 2004 We reproducibly observed that pol beta is an efficient covalent target for ADP-ribose polymers under standard conditions of enzymatically catalyzed ADP-ribosylation of betaNAD+ as a substrate. Adenosine Diphosphate 75-78 DNA polymerase beta Homo sapiens 30-38 15525581-6 2004 SHP overexpression increased the glucose sensitivity of ATP-sensitive K+ (KATP) channels and enhanced the ATP/ADP ratio. Adenosine Diphosphate 110-113 nuclear receptor subfamily 0 group B member 2 Homo sapiens 0-3 15247304-7 2004 By equilibrium titration, both heads of a myosin VI dimer bind actin strongly in rigor and with bound ADP. Adenosine Diphosphate 102-105 myosin VI Homo sapiens 42-51 15059849-5 2004 Despite wild-type levels of alphaIIbbeta3, caspase-12(-/-) platelets exhibit reduced fibrinogen binding to alphaIIbbeta3 following stimulation by adenosine diphosphate (ADP) or protease-activated receptor 4 (PAR4) receptor-activating peptide. Adenosine Diphosphate 146-167 caspase 12 Mus musculus 43-53 15059849-5 2004 Despite wild-type levels of alphaIIbbeta3, caspase-12(-/-) platelets exhibit reduced fibrinogen binding to alphaIIbbeta3 following stimulation by adenosine diphosphate (ADP) or protease-activated receptor 4 (PAR4) receptor-activating peptide. Adenosine Diphosphate 169-172 caspase 12 Mus musculus 43-53 15333577-5 2004 Whereas TXA2 has minimal effects, released ADP via only P2Y12 potentiates platelet adhesion to the octapeptide. Adenosine Diphosphate 43-46 purinergic receptor P2Y12 Homo sapiens 56-61 15205456-4 2004 The inhibitor preferentially binds to the ATPase intermediate with ADP and phosphate bound at the active site, and it slows down phosphate release. Adenosine Diphosphate 67-70 dynein axonemal heavy chain 8 Homo sapiens 42-48 15059954-5 2004 Introduction of the small interfering RNA increased the ATP/ADP ratio and partially rescued the glucose-stimulated insulin secretion in the cells overexpressing SREBP-1c, but did not affect the cellular TG content. Adenosine Diphosphate 60-63 sterol regulatory element binding transcription factor 1 Rattus norvegicus 161-169 15123708-0 2004 Human deafness mutation of myosin VI (C442Y) accelerates the ADP dissociation rate. Adenosine Diphosphate 61-64 myosin VI Homo sapiens 27-36 15123708-3 2004 The largest changes in the kinetic mechanism of ATP hydrolysis produced by the C442Y mutation are about 10-fold increases in the rate of ADP dissociation from both myosin VI and actomyosin VI. Adenosine Diphosphate 137-140 myosin VI Homo sapiens 164-173 15123708-4 2004 The rates of ADP dissociation from acto-C442Y myosin VI-ADP and C442Y myosin VI-ADP are 20-40 times more rapid than the steady state rates and cannot be the rate-limiting steps of the hydrolysis mechanism in the presence or absence of actin. Adenosine Diphosphate 13-16 myosin VI Homo sapiens 46-55 15123708-4 2004 The rates of ADP dissociation from acto-C442Y myosin VI-ADP and C442Y myosin VI-ADP are 20-40 times more rapid than the steady state rates and cannot be the rate-limiting steps of the hydrolysis mechanism in the presence or absence of actin. Adenosine Diphosphate 13-16 myosin VI Homo sapiens 70-79 15105434-2 2004 The MSH2.MSH6 heterodimer binds 1 mol of ADP and 1 mol of adenosine 5"-O-(thiotriphosphate) (ATPgammaS), with a K(d) for each nucleotide of about 1 microm. Adenosine Diphosphate 41-44 mutS homolog 2 Homo sapiens 4-8 15163471-4 2004 3.1.3.5, CD73) that can control the levels of ADP and adenosine, two substances that regulates platelet aggregation. Adenosine Diphosphate 46-49 5' nucleotidase, ecto Rattus norvegicus 9-13 15182206-1 2004 The human fragile histidine triad protein Fhit catalyzes the Mg(2+)-dependent hydrolysis of P(1)-5"-O-adenosine-P(3)-5"-O-adenosine triphosphate, Ap(3)A, to AMP and ADP. Adenosine Diphosphate 165-168 fragile histidine triad diadenosine triphosphatase Homo sapiens 42-46 15182206-2 2004 The reaction is thought to follow a two-step mechanism, in which the complex of Ap(3)A and Mg(2+) reacts in the first step with His96 of the enzyme to form a covalent Fhit-AMP intermediate and release MgADP. Adenosine Diphosphate 201-206 fragile histidine triad diadenosine triphosphatase Homo sapiens 167-171 15238515-0 2004 Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae. Adenosine Diphosphate 126-129 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 110-114 15140134-4 2004 ADP-induced P-selectin expression was inhibited both by MRS 2179 (a P2Y1 selective antagonist) and AR-C69931MX (a P2Y12 selective antagonist), suggesting a role for both Galpha(q) and Galpha(i) pathways in ADP-mediated alpha granule release. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 114-119 14766983-2 2004 Here, we report the engineering of a myosin Vb mutant that still hydrolyzes ATP, yet is selectively sensitized to an N(6)-substituted ADP analog that inhibits its activity, causing it to remain tightly bound to actin. Adenosine Diphosphate 134-137 myosin VB Homo sapiens 37-46 15286382-3 2004 The mitochondrial transmembrane potential (Delta(Psi)m) reflects the energy stored in the electrochemical gradient across the inner mitochondrial membrane, which in turn is used by F0F1-ATPase to convert adenosine 5"-diphosphate to ATP during oxidative phosphorylation. Adenosine Diphosphate 204-228 ATP synthase F1 subunit epsilon Homo sapiens 181-192 14752238-2 2004 As an isoform of plasma hemopexin (Hx) with protease activity may be implicated in this disease, we have studied the inhibition of Hx by ADP and reactivation to its active form by endothelial or mesangial cells in vitro. Adenosine Diphosphate 137-140 hemopexin Homo sapiens 24-33 14514697-3 2003 Dissociation constants (KD) for Atm1-C binding of ATP (KD approximately 97 microm, pH 7.3, and approximately 102 microm, pH 10.0) and ADP (KD approximately 43 microm, pH 7.3, and 92 microm, pH 10.0) were measured by fluorimetry. Adenosine Diphosphate 134-137 ATP-binding cassette Fe/S cluster precursor transporter ATM1 Saccharomyces cerevisiae S288C 32-36 14514697-5 2003 ADP also had an inhibitory effect on Atm1-C with an IC50 of 10 mm. Adenosine Diphosphate 0-3 ATP-binding cassette Fe/S cluster precursor transporter ATM1 Saccharomyces cerevisiae S288C 37-41 14662702-1 2003 BACKGROUND: We recently described a gain-of-function haplotype, called H2, of the adenosine diphosphate (ADP) receptor P2Y12 gene associated with increased ADP-induced platelet aggregation ex vivo in healthy volunteers. Adenosine Diphosphate 105-108 purinergic receptor P2Y12 Homo sapiens 119-124 14679173-3 2003 A new study demonstrates that hyperglycemia-induced mitochondrial superoxide production activates uncoupling protein 2, which decreases the ATP/ADP ratio and thus reduces the insulin-secretory response. Adenosine Diphosphate 144-147 uncoupling protein 2 Homo sapiens 98-118 14675082-6 2003 Treatment of cells with agonists of platelet activation (ADP, epinephrine, and thrombin receptor-activating peptide) resulted in the release of VWF antigen and active FVIII into the supernatant from transduced cells. Adenosine Diphosphate 57-60 coagulation factor VIII Homo sapiens 167-172 12807884-7 2003 In contrast to many AAA chaperones that require ATP/ADP to form oligomers, both wild type VCP and ATP-binding site mutants can form hexamers without the addition of nucleotide. Adenosine Diphosphate 52-55 valosin containing protein Homo sapiens 90-93 12807884-9 2003 Tryptophan fluorescence and trypsin digestion analyses showed that ATP/ADP binding induces dramatic conformational changes in VCP. Adenosine Diphosphate 71-74 valosin containing protein Homo sapiens 126-129 12912815-0 2003 Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 70-75 12912815-8 2003 CONCLUSIONS: In healthy subjects, ADP-induced platelet aggregation is associated with a haplotype of the P2Y12 receptor gene. Adenosine Diphosphate 34-37 purinergic receptor P2Y12 Homo sapiens 105-110 12815166-1 2003 The P2Y13 receptor has recently been identified as a new P2Y receptor sharing a high sequence homology with the P2Y12 receptor as well as similar functional properties: coupling to Gi and responsiveness to ADP (Communi et al., 2001). Adenosine Diphosphate 206-209 purinergic receptor P2Y13 Homo sapiens 4-9 13678275-2 2003 To find out which amino acids are implicated in the transition between these two conformations, which occurs during transport, mutants of the Saccharomyces cerevisiae ADP/ATP carrier Anc2p responsible for resistance of yeast cells to BA were identified and characterized after in vivo chemical or UV mutagenesis. Adenosine Diphosphate 167-170 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 183-188 13678275-6 2003 ADP/ATP exchange mediated by Anc2p variants in isolated mitochondria was more efficient than that of the wild-type Anc2p in the presence of BA, confirming that BA resistance of the mutant cells was linked to the functional properties of the modified ADP/ATP carrier. Adenosine Diphosphate 0-3 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 29-34 12729897-8 2003 These results provide evidence for a PLC gamma 2-independent collagen activation pathway requiring cooperation between GPVI and alpha(2)beta(1) leading to alpha(IIb)beta(3)-dependent aggregation and shape change by released ADP and thromboxane A(2). Adenosine Diphosphate 224-227 glycoprotein 6 (platelet) Mus musculus 119-123 12556467-7 2003 We found that GRx catalyzes GSSG formation in the presence of GS-thiyl radical generating systems (Fe(2+)/ADP/H(2)O(2) + GSH or horseradish peroxidase/H(2)O(2) + GSH). Adenosine Diphosphate 106-109 glutaredoxin Homo sapiens 14-17 12513690-0 2003 Kinetic studies of rat liver hexokinase D ("glucokinase") in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released. Adenosine Diphosphate 120-125 glucokinase Rattus norvegicus 29-41 12513690-0 2003 Kinetic studies of rat liver hexokinase D ("glucokinase") in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released. Adenosine Diphosphate 120-125 glucokinase Rattus norvegicus 44-56 12596269-0 2003 Hidden order in the GroEL-GroES-(ADP)7 chaperonin: forms, folding, and ADP-binding sites. Adenosine Diphosphate 33-36 heat shock protein family E (Hsp10) member 1 Homo sapiens 26-31 12356756-6 2002 BAP stimulated the ATPase activity of BiP when added alone or together with the ER DnaJ protein, ERdj4, by promoting the release of ADP from BiP. Adenosine Diphosphate 132-135 DnaJ heat shock protein family (Hsp40) member B9 Homo sapiens 97-102 12482826-3 2002 The activity of endothelial ectonucleotidases was assessed by the production of inorganic phosphate from ADP, which was decreased by chronic depolarization by 25% (n=6, P<0.05) and the amount of AMP derived from ADP in the presence of the 5"-nucleotidase inhibitor alpha,beta-methylene-5"-diphosphate (100 micromol/L). Adenosine Diphosphate 105-108 5'-nucleotidase ecto Homo sapiens 242-257 12475777-9 2002 We also clarify the mechanism by which MgADP produces an apparent increase of sulfonylurea efficacy on channels containing SUR1 (but not SUR2). Adenosine Diphosphate 39-44 ATP binding cassette subfamily C member 8 Homo sapiens 123-127 12403632-1 2002 It has been suggested that the mechanical condition determines the rate-limiting step of the ATPase of the myosin heads in fibers: when fibers are isometrically contracting, the ADP release kinetics are rate-limiting, but as the strain is reduced and the fibers are allowed to shorten, the ADP release kinetics accelerate and P(i) release becomes rate-limiting. Adenosine Diphosphate 178-181 dynein axonemal heavy chain 8 Homo sapiens 93-99 12403632-1 2002 It has been suggested that the mechanical condition determines the rate-limiting step of the ATPase of the myosin heads in fibers: when fibers are isometrically contracting, the ADP release kinetics are rate-limiting, but as the strain is reduced and the fibers are allowed to shorten, the ADP release kinetics accelerate and P(i) release becomes rate-limiting. Adenosine Diphosphate 290-293 dynein axonemal heavy chain 8 Homo sapiens 93-99 12356871-3 2002 Binding of Hsp70-peptide complex to the exoplasmic domain of CD40 is mediated by the NH(2)-terminal nucleotide-binding domain of Hsp70 in its ADP state. Adenosine Diphosphate 142-145 CD40 molecule Homo sapiens 61-65 12356871-5 2002 Binding of Hsp70-ADP to CD40 is strongly increased in the presence of Hsp70 peptide substrate, and induces signaling via p38. Adenosine Diphosphate 17-20 CD40 molecule Homo sapiens 24-28 12015326-7 2002 The two essential requirements for cross-linking of N30C-PLB to SERCA2a were a Ca(2+)-free enzyme and, unexpectedly, a micromolar concentration of ATP or ADP, demonstrating that N30C-PLB cross-links preferentially to the nucleotide-bound, E2 state of SERCA2a. Adenosine Diphosphate 154-157 phospholamban Homo sapiens 57-60 12015326-7 2002 The two essential requirements for cross-linking of N30C-PLB to SERCA2a were a Ca(2+)-free enzyme and, unexpectedly, a micromolar concentration of ATP or ADP, demonstrating that N30C-PLB cross-links preferentially to the nucleotide-bound, E2 state of SERCA2a. Adenosine Diphosphate 154-157 phospholamban Homo sapiens 183-186 12065294-6 2002 In the absence of the inhibitor/regenerator system, extracellular ATP was rapidly broken down to ADP, AMP, and adenosine. Adenosine Diphosphate 97-100 ATPase phospholipid transporting 8A2 Homo sapiens 66-69 12096063-4 2002 We found that the sigmoidal MgADP-tension relationship became hyperbolic after a partial extraction of LC2 (about 30 %) and TnC (about 70 %). Adenosine Diphosphate 28-33 tenascin C Bos taurus 124-127 12096063-7 2002 The partial extraction of LC2 and TnC resulted in a reduction of the inhibitory effect of inorganic phosphate (P(i)) on the MgADP-activated tension. Adenosine Diphosphate 124-129 tenascin C Bos taurus 34-37 12052876-5 2002 We found that Fes1p associates preferentially to the ADP-bound form of the cytosolic Hsp70 molecular chaperone Ssa1p and promotes nucleotide release. Adenosine Diphosphate 53-56 Fes1p Saccharomyces cerevisiae S288C 14-19 11970953-5 2002 We also show that platelets from mice lacking G(alpha)(i2), which couples to the ADP receptor, P2Y12, exhibit reduced Rap1 activation in response to ADP. Adenosine Diphosphate 81-84 RAS-related protein 1a Mus musculus 118-122 11970953-6 2002 In contrast, platelets from mice that lack G(alpha)(q) show no decrease in the ability to activate Rap1 in response to epinephrine but show a partial reduction in ADP-stimulated Rap1 activation. Adenosine Diphosphate 163-166 RAS-related protein 1a Mus musculus 178-182 11916974-4 2002 We now show that Cdc37p/p50(cdc37), like Sti1/Hop/p60, also suppresses ATP turnover by Hsp90 supporting the idea that client protein loading to Hsp90 requires a "relaxed" ADP-bound conformation. Adenosine Diphosphate 171-174 cell division cycle 37, HSP90 cochaperone Homo sapiens 17-23 11916974-4 2002 We now show that Cdc37p/p50(cdc37), like Sti1/Hop/p60, also suppresses ATP turnover by Hsp90 supporting the idea that client protein loading to Hsp90 requires a "relaxed" ADP-bound conformation. Adenosine Diphosphate 171-174 cell division cycle 37, HSP90 cochaperone Homo sapiens 28-33 12121659-4 2002 Furthermore, CD28 controls a primary response pathway, inducing a level of glucose uptake and glycolysis in excess of that needed to maintain cellular ATP/ADP levels or macromolecular synthesis. Adenosine Diphosphate 155-158 CD28 molecule Homo sapiens 13-17 12034376-5 2002 SC-57101A inhibited the collagen- and ADP-induced release of platelet-derived growth factor (PDGF) and beta-thromboglobulin (beta-TG) from platelets, but not TRAP-induced secretion of these granule contents. Adenosine Diphosphate 38-41 pro-platelet basic protein Homo sapiens 103-123 12034376-5 2002 SC-57101A inhibited the collagen- and ADP-induced release of platelet-derived growth factor (PDGF) and beta-thromboglobulin (beta-TG) from platelets, but not TRAP-induced secretion of these granule contents. Adenosine Diphosphate 38-41 pro-platelet basic protein Homo sapiens 125-132 11867634-3 2002 Channels formed by co-transfection of Kir6.2 and the mutant SUR1 in COS cells have reduced response to MgADP ( approximately 10% that of the wild-type channels) and reduced surface expression ( approximately 19% that of the wild-type channels). Adenosine Diphosphate 103-108 ATP binding cassette subfamily C member 8 Homo sapiens 60-64 11961076-4 2002 ADP potently stimulates SP174 with an EC(50) of 60 nM, and other related nucleotides are active as well, with a rank order of potency 2-methylthio-ADP tetrasodium = adenosine 5"-O-2-(thio)diphosphate = 2-methylthio-ATP tetrasodium > ADP > AP3A >ATP > IDP. Adenosine Diphosphate 0-3 purinergic receptor P2Y13 Homo sapiens 24-29 11909819-0 2002 Intramolecular interaction of SUR2 subtypes for intracellular ADP-Induced differential control of K(ATP) channels. Adenosine Diphosphate 62-65 ATP binding cassette subfamily C member 9 Homo sapiens 30-34 11909819-2 2002 The C-terminal 42 amino acid residues (C42) of SURs are responsible for ADP-induced differential activation of K(ATP) channels in SUR-subtypes. Adenosine Diphosphate 72-75 ATP binding cassette subfamily C member 9 Homo sapiens 47-50 11909819-6 2002 Therefore, the interaction might be involved in the control of ADP-induced differential activation of SUR2-subtype K(ATP) channels. Adenosine Diphosphate 63-66 ATP binding cassette subfamily C member 9 Homo sapiens 102-106 11888286-5 2002 AMPPNP inhibition assays and ATP/ADP binding assays provide binding constants for ATP and ADP to DbpA with and without RNA substrates. Adenosine Diphosphate 33-36 ATPase Escherichia coli 82-93 11896678-3 2002 The latter is first sequestered and eventually hydrolyzed by Fhit to ADP and AMP. Adenosine Diphosphate 69-72 fragile histidine triad diadenosine triphosphatase Homo sapiens 61-65 11827541-3 2002 Here we show that the extracellular domain of CD39L1 ecto-adenosine triphosphatase (ecto-ATPase) has the same 3:1 ATP:ADP hydrolysis ratio as the extracellular domain of CD39, suggesting that the transmembrane domains are required to confer the native substrate specificities on each enzyme. Adenosine Diphosphate 118-121 dynein axonemal heavy chain 8 Homo sapiens 89-95 12806027-3 2002 Both pharmacological and molecular biological approaches have confirmed the role of the P2Y1 and P2Y12 receptors in the ADP-induced platelet fibrinogen receptor activation. Adenosine Diphosphate 120-123 purinergic receptor P2Y12 Homo sapiens 97-102 12806027-5 2002 Whereas the P2Y12 receptor mediates the potentiation of dense granule release reaction, both the P2Y1 and P2Y12 receptors play an important role in the ADP-induced phospholipase A2 activation. Adenosine Diphosphate 152-155 purinergic receptor P2Y12 Homo sapiens 106-111 11788345-0 2002 Transgenic livers expressing mitochondrial and cytosolic CK: mitochondrial CK modulates free ADP levels. Adenosine Diphosphate 93-96 creatine kinase, brain Mus musculus 75-77 11788345-8 2002 Hepatic free ADP concentrations calculated by assuming equilibrium of the CK-catalyzed reaction in vivo decreased from 84 +/- 9 to 38 +/- 4 nmol/g wet wt. Adenosine Diphosphate 13-16 creatine kinase, brain Mus musculus 74-76 11704681-7 2002 When the interaction of CIB with the alpha(IIb) cytoplasmic tail is blocked in native platelets by a permeable competing peptide, alpha(IIb)beta(3) activation is not detected even in the presence of ADP. Adenosine Diphosphate 199-202 calcium and integrin binding 1 Homo sapiens 24-27 11756171-1 2002 Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A(2), another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. Adenosine Diphosphate 0-21 purinergic receptor P2Y12 Homo sapiens 198-203 11756171-1 2002 Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A(2), another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. Adenosine Diphosphate 23-26 purinergic receptor P2Y12 Homo sapiens 198-203 12200962-6 2002 TOMM70A could play a significant role in the import of nuclear-encoded mitochondrial proteins with internal targeting sites such as ADP/ATP carriers and the uncoupling proteins. Adenosine Diphosphate 132-135 translocase of outer mitochondrial membrane 70 Homo sapiens 0-7 11788762-7 2002 Assay of PEPCK activity in crude extracts of Guinea grass leaves, showed a large difference between illuminated and darkened leaves when measured in a selective assay (a low concentration of phosphoenolpyruvate and a high ratio of ATP to ADP), but there was no difference under assay conditions used to estimate maximum activity. Adenosine Diphosphate 238-241 phosphoenolpyruvate carboxykinase (ATP) Zea mays 9-14 11546658-7 2001 Two G(i alpha) proteins (G(i alpha 2) and G(i alpha 3)), which have been implicated in the control of membrane trafficking, reacted with PTX in ADP-ribosylation studies. Adenosine Diphosphate 144-147 G protein subunit alpha i3 Rattus norvegicus 42-53 11502873-2 2001 ADP-induced platelet aggregation is mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y(1), and Gi-linked P2T(AC), which has not been cloned. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 126-133 11502873-5 2001 HORK3, when transfected in the rat glioma cell subline (C6-15), responded to 2-methylthio-ADP (2MeSADP) (EC(50) = 0.08 nM) and ADP (EC(50) = 42 nM) with inhibition of forskolin-stimulated cAMP accumulation. Adenosine Diphosphate 90-93 purinergic receptor P2Y12 Homo sapiens 0-5 11502873-7 2001 These results show that HORK3 is a Gi/o-coupled receptor and that its natural ligand is ADP. Adenosine Diphosphate 88-91 purinergic receptor P2Y12 Homo sapiens 24-29 11456222-1 2001 The influences of Mn2+, Mg2+, and Ca2+ on the enzymic activity of chloroplast ATPase have been compared, using an HPLC method for the separation of ADP. Adenosine Diphosphate 148-151 dynein axonemal heavy chain 8 Homo sapiens 78-84 11096111-5 2001 Purified Ssc1--2 had a lowered affinity for a peptide substrate compared with wild-type Ssc1 but only in the ADP-bound state. Adenosine Diphosphate 109-112 ELOVL fatty acid elongase 1 Homo sapiens 9-13 11102440-9 2001 The transient increase in Delta Psi(m) was blocked by oligomycin, an inhibitor of F(0)F(1-)ATPase that may have undergone reversal caused by the abnormal ADP-ATP balance within mitochondria. Adenosine Diphosphate 154-157 ATP synthase F1 subunit epsilon Homo sapiens 82-97 11102440-10 2001 These findings suggest a novel sequence of early events following trophic factor withdrawal in which alkaline pH inhibits ADP import into mitochondria, reversing the F(0)F(1-)ATPase, which in turn consumes ATP and pumps out protons, raising Delta Psi(m). Adenosine Diphosphate 122-125 ATP synthase F1 subunit epsilon Homo sapiens 166-181 11159520-0 2001 Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function. Adenosine Diphosphate 0-21 C-C motif chemokine ligand 17 Homo sapiens 78-82 11159520-0 2001 Adenosine diphosphate strongly potentiates the ability of the chemokines MDC, TARC, and SDF-1 to stimulate platelet function. Adenosine Diphosphate 0-21 C-X-C motif chemokine ligand 12 Homo sapiens 88-93 11159520-7 2001 TARC, MDC, and SDF-1 increased intracellular calcium concentrations [Ca(2+)](i) when combined with low levels of ADP. Adenosine Diphosphate 113-116 C-C motif chemokine ligand 17 Homo sapiens 0-4 11159520-7 2001 TARC, MDC, and SDF-1 increased intracellular calcium concentrations [Ca(2+)](i) when combined with low levels of ADP. Adenosine Diphosphate 113-116 C-C motif chemokine ligand 22 Homo sapiens 6-9 11159520-7 2001 TARC, MDC, and SDF-1 increased intracellular calcium concentrations [Ca(2+)](i) when combined with low levels of ADP. Adenosine Diphosphate 113-116 C-X-C motif chemokine ligand 12 Homo sapiens 15-20 11159520-10 2001 These findings suggest that the chemokines MDC, TARC, and SDF-1, which may be produced during inflammatory responses, coupled with low levels of ADP or thrombin, can serve as strong stimuli for activating platelet function. Adenosine Diphosphate 145-148 C-C motif chemokine ligand 22 Homo sapiens 43-46 11159520-10 2001 These findings suggest that the chemokines MDC, TARC, and SDF-1, which may be produced during inflammatory responses, coupled with low levels of ADP or thrombin, can serve as strong stimuli for activating platelet function. Adenosine Diphosphate 145-148 C-X-C motif chemokine ligand 12 Homo sapiens 58-63 11020387-4 2001 This suggests that the unusual asymmetric conformation of dimeric kinesin in the microtubule-independent ADP state is likely to be a general feature of the kinesin heavy chain subfamily. Adenosine Diphosphate 105-108 Kinesin heavy chain Drosophila melanogaster 66-73 11020387-4 2001 This suggests that the unusual asymmetric conformation of dimeric kinesin in the microtubule-independent ADP state is likely to be a general feature of the kinesin heavy chain subfamily. Adenosine Diphosphate 105-108 Kinesin heavy chain Drosophila melanogaster 156-163 10993895-6 2000 However, the MgATP and MgADP affinities of NBF2 of SUR1-R1420C were about 5-fold lower than those of wild-type SUR1. Adenosine Diphosphate 23-28 ATP binding cassette subfamily C member 8 Homo sapiens 51-55 10993895-7 2000 MgATP and MgADP stabilized 8-azido-ATP binding at NBF1 of wild-type SUR1 by interacting with NBF2, but this cooperative nucleotide binding was not observed for SUR1-R1420C. Adenosine Diphosphate 10-15 ATP binding cassette subfamily C member 8 Homo sapiens 68-72 10948193-8 2000 Analysis of the relative rates of hydrolysis of nucleoside diphosphates (GDP = IDP > UDP > CDP >> ADP) suggests that soluble eNTPDase6 is a diphosphatase most likely not involved in regulation of ADP levels important for circulatory hemostasis. Adenosine Diphosphate 110-113 cut like homeobox 1 Homo sapiens 97-100 11271505-0 2000 The role of ATP, ADP and divalent cations in the formation of binary and ternary complexes of actin, cofilin and DNase I. Actin is the major cytoskeletal protein of virtually all eukaryotic cells. Adenosine Diphosphate 17-20 cofilin 1 Homo sapiens 101-108 11271505-5 2000 Preferential conditions for the formation of the binary actin-cofilin complex are: ADP-Mg2+ > or = ADP-Ca2+ >> ATP-Ca2+ approximately equals ATP-Mg2+ approximately equals ADP-No Me2+ approximately equals ATP-No Me2+. Adenosine Diphosphate 83-86 cofilin 1 Homo sapiens 62-69 11271505-5 2000 Preferential conditions for the formation of the binary actin-cofilin complex are: ADP-Mg2+ > or = ADP-Ca2+ >> ATP-Ca2+ approximately equals ATP-Mg2+ approximately equals ADP-No Me2+ approximately equals ATP-No Me2+. Adenosine Diphosphate 83-87 cofilin 1 Homo sapiens 62-69 11271505-8 2000 Finally, the conditions which favour the formation of a ternary complex of cofilin-actin-DNase I resemble the actin-DNase I, namely: ATP-Ca2+ approximately equals ADP-Ca2+ approximately equals ADP-Mg2+ approximately equals ATPMg2+ ADP (no Me2+) > ATP-(no Me2+). Adenosine Diphosphate 163-166 cofilin 1 Homo sapiens 75-82 11271505-8 2000 Finally, the conditions which favour the formation of a ternary complex of cofilin-actin-DNase I resemble the actin-DNase I, namely: ATP-Ca2+ approximately equals ADP-Ca2+ approximately equals ADP-Mg2+ approximately equals ATPMg2+ ADP (no Me2+) > ATP-(no Me2+). Adenosine Diphosphate 193-196 cofilin 1 Homo sapiens 75-82 11117432-2 2000 In this study, we investigated the putative role of a T/G-polymorphism (exon 33, codon 1369; S1369A) in the adenosine diphosphate-sensing nucleotide-binding fold-2 (NBF-2) of the SUR-1 on glucose-induced insulin secretion during an oral glucose tolerance test in pregnant women (PW; n=182). Adenosine Diphosphate 108-129 ATP binding cassette subfamily C member 8 Homo sapiens 179-184 11127876-2 2000 S-nitroso-AR545C - an S-nitrosoderivative of a recombinant von Willebrand factor fragment AR545C spanning Ala 444 to Asp 730 and containing an Arg 545 Cys mutation, was previously found to inhibit ristocetin- and ADP-induced platelet aggregation and the interaction of platelets with extracellular matrix (ECM). Adenosine Diphosphate 213-216 von Willebrand factor Cavia porcellus 59-80 11052670-2 2000 Profilin binding to actin decreases the affinity of actin for MgADP and MgATP by about 65- and 13-fold, respectively. Adenosine Diphosphate 62-67 actin epsilon 1 Bos taurus 20-25 11052670-2 2000 Profilin binding to actin decreases the affinity of actin for MgADP and MgATP by about 65- and 13-fold, respectively. Adenosine Diphosphate 62-67 actin epsilon 1 Bos taurus 52-57 11069108-6 2000 The ADF/cofilin protein actophorin reduced the half time for both dissociation of gamma-phosphate from ADP-Pi-actin filaments and debranching to 30 seconds. Adenosine Diphosphate 103-106 destrin, actin depolymerizing factor Homo sapiens 4-15 10869362-2 2000 In the presence of the substrates glutamate and malate, a 2.3 +/- 0.2-fold excess capacity of COX was observed in ADP-stimulated human skeletal muscle fibers. Adenosine Diphosphate 114-117 cytochrome c oxidase subunit 8A Homo sapiens 94-97 10969013-0 2000 ADP inhibition of myosin V ATPase activity. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 27-33 10969013-15 2000 Under standard assay conditions, ADP competes with ATP, resulting in product inhibition of the ATPase rate. Adenosine Diphosphate 33-36 dynein axonemal heavy chain 8 Homo sapiens 95-101 10960076-1 2000 ADP, an important agonist in thrombosis and haemostasis, has been reported to activate platelets via three receptors, P2X(1), P2Y(1) and P2T(AC). Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Homo sapiens 137-144 10962016-8 2000 Excising patches into a solution containing MgADP prevented this phenomenon, suggesting that fast rundown involves loss of MgADP-dependent stimulation conferred by SUR1. Adenosine Diphosphate 44-49 ATP binding cassette subfamily C member 8 Homo sapiens 164-168 10962016-8 2000 Excising patches into a solution containing MgADP prevented this phenomenon, suggesting that fast rundown involves loss of MgADP-dependent stimulation conferred by SUR1. Adenosine Diphosphate 123-128 ATP binding cassette subfamily C member 8 Homo sapiens 164-168 10962016-16 2000 In summary, short-term regulation of Kir6.2+SUR1 channels involves MgADP, while long-term regulation requires PIP(2) and phosphorylation. Adenosine Diphosphate 67-72 ATP binding cassette subfamily C member 8 Homo sapiens 44-48 10920025-10 2000 In all fibers, peak efficiency increased to approximately 0.4 when the temperature was raised from 12 degrees C to 20 degrees C. The results were simulated with a kinetic scheme describing the ATPase cycle, in which the rate constant controlling ADP release is sensitive to the load on the muscle. Adenosine Diphosphate 246-249 dynein axonemal heavy chain 8 Homo sapiens 193-199 10884507-4 2000 Aggregation of ADP-treated fixed platelets caused by the addition of fibrinogen was inhibited by RGDS but not by TA-993 and MB3. Adenosine Diphosphate 15-18 ral guanine nucleotide dissociation stimulator Homo sapiens 97-101 10891429-8 2000 Further, second-wave aggregation induced by MDC in platelet-rich plasma was inhibited by aspirin, ADP scavenger creatine phosphate/creative phosphokinase (CP/CPK), and ARL-66096, an antagonist of the ADP P2T(AC) receptor involved in adenylyl cyclase inhibition. Adenosine Diphosphate 98-101 C-C motif chemokine ligand 22 Homo sapiens 44-47 10833411-2 2000 The potentiatory effect of MgADP is conferred by the sulfonylurea receptor subunit of the channel, SUR, whereas the inhibitory effect of ATP appears to be mediated via the pore-forming subunit, Kir6.2. Adenosine Diphosphate 27-32 ATP binding cassette subfamily C member 8 Homo sapiens 99-102 10833391-1 2000 A functional recombinant mitochondrial ADP/ATP carrier from the yeast Saccharomyces cerevisiae that bears a six-histidine tag at the C-terminus, Anc2(His(6))p, has been engineered to allow its purification by immobilized metal-ion affinity chromatography (IMAC). Adenosine Diphosphate 39-42 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 145-149 10833391-5 2000 Anc2(His(6))p interacted differently with immobilized ions depending on whether it was unliganded or bound to carboxyatractyloside (CATR) or bongkrekic acid (BA), two specific inhibitors of the ADP/ATP transport, thus indicating that accessibility of the C-terminus is markedly influenced by the conformational state of the carrier. Adenosine Diphosphate 194-197 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 0-4 10833391-6 2000 Fluorometric assays demonstrated that purified unliganded Anc2(His(6))p was in a functional state since it underwent CATR- and BA-sensitive and ADP (or ATP)-induced conformational changes. Adenosine Diphosphate 144-147 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 58-62 10833391-7 2000 Large-scale purification of Anc2(His(6))p-CATR and Anc2(His(6))p-BA complexes by IMAC will be of major interest for structural analysis of the ADP/ATP carrier. Adenosine Diphosphate 143-146 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 28-32 10833391-7 2000 Large-scale purification of Anc2(His(6))p-CATR and Anc2(His(6))p-BA complexes by IMAC will be of major interest for structural analysis of the ADP/ATP carrier. Adenosine Diphosphate 143-146 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 51-55 10748134-7 2000 PDK3 activity was stimulated upon reductive acetylation of L1 and L2 when full activation of PDK3 by E2 was avoided (e.g. using free lipoyl domains or ADP-inhibited E2-activated PDK3). Adenosine Diphosphate 151-154 pyruvate dehydrogenase kinase 3 Homo sapiens 0-4 10748134-10 2000 E2-activated PDK2 activity was stimulated >/=3-fold by reductive acetylation of E2; stimulated PDK2 retained high sensitivity to inhibition by ADP and DCA. Adenosine Diphosphate 146-149 pyruvate dehydrogenase kinase 2 Homo sapiens 13-17 10748134-10 2000 E2-activated PDK2 activity was stimulated >/=3-fold by reductive acetylation of E2; stimulated PDK2 retained high sensitivity to inhibition by ADP and DCA. Adenosine Diphosphate 146-149 pyruvate dehydrogenase kinase 2 Homo sapiens 98-102 10788495-4 2000 This preparation as well as Gbeta(1)gamma(2-His) supported pertussis toxin-mediated ADP-ribosylation of Galpha(i1). Adenosine Diphosphate 84-87 succinate-CoA ligase GDP-forming subunit beta Homo sapiens 28-33 10625635-9 2000 The presence of MgATP or MgADP leads to faster inhibition of the ATPase by EDC in unsealed membrane fragments than in sealed vesicles, suggesting that binding of MgATP or MgADP to the ATPase leads to a conformational change on the lumenal side of the membrane. Adenosine Diphosphate 25-30 dynein axonemal heavy chain 8 Homo sapiens 65-71 10625635-9 2000 The presence of MgATP or MgADP leads to faster inhibition of the ATPase by EDC in unsealed membrane fragments than in sealed vesicles, suggesting that binding of MgATP or MgADP to the ATPase leads to a conformational change on the lumenal side of the membrane. Adenosine Diphosphate 25-30 dynein axonemal heavy chain 8 Homo sapiens 184-190 10625635-9 2000 The presence of MgATP or MgADP leads to faster inhibition of the ATPase by EDC in unsealed membrane fragments than in sealed vesicles, suggesting that binding of MgATP or MgADP to the ATPase leads to a conformational change on the lumenal side of the membrane. Adenosine Diphosphate 171-176 dynein axonemal heavy chain 8 Homo sapiens 65-71 10625635-9 2000 The presence of MgATP or MgADP leads to faster inhibition of the ATPase by EDC in unsealed membrane fragments than in sealed vesicles, suggesting that binding of MgATP or MgADP to the ATPase leads to a conformational change on the lumenal side of the membrane. Adenosine Diphosphate 171-176 dynein axonemal heavy chain 8 Homo sapiens 184-190 10581363-6 1999 In this article, we present a model in which the activity of the K(ATP) channel is determined by the balance of the action of ADP, which activates the channel through SUR1, and the action of ATP, which stabilizes the long closed state by binding to Kir6.2. Adenosine Diphosphate 126-129 ATPase phospholipid transporting 8A2 Homo sapiens 67-70 10581363-6 1999 In this article, we present a model in which the activity of the K(ATP) channel is determined by the balance of the action of ADP, which activates the channel through SUR1, and the action of ATP, which stabilizes the long closed state by binding to Kir6.2. Adenosine Diphosphate 126-129 ATP binding cassette subfamily C member 8 Homo sapiens 167-171 10581363-6 1999 In this article, we present a model in which the activity of the K(ATP) channel is determined by the balance of the action of ADP, which activates the channel through SUR1, and the action of ATP, which stabilizes the long closed state by binding to Kir6.2. Adenosine Diphosphate 126-129 ATPase phospholipid transporting 8A2 Homo sapiens 191-194 10567242-7 1999 All the active-site amino acids for the binding of ADP, P(i) and metal ions are similarly preserved, matching entirely those of human hepatic SAMS and Escherichia coli SAMS. Adenosine Diphosphate 51-54 methionine adenosyltransferase 1A Homo sapiens 142-146 10567242-7 1999 All the active-site amino acids for the binding of ADP, P(i) and metal ions are similarly preserved, matching entirely those of human hepatic SAMS and Escherichia coli SAMS. Adenosine Diphosphate 51-54 methionine adenosyltransferase 1A Homo sapiens 168-172 10657530-6 1999 The marked effect of the non-hydrolysable adenosine nucleotide App(NH)p also supports a cAMP-dependent TyrOH activation not related to ADP or an ADP-dependent mechanism. Adenosine Diphosphate 135-138 tyrosine hydroxylase Rattus norvegicus 103-108 10504387-0 1999 Orientation of GTP and ADP within their respective binding sites in glutamate dehydrogenase. Adenosine Diphosphate 23-26 glutamate dehydrogenase 1, mitochondrial Bos taurus 68-91 10504387-1 1999 Previous studies have identified the guanine and adenine binding domains of the GTP and ADP binding sites of GDH. Adenosine Diphosphate 88-91 glutamate dehydrogenase 1, mitochondrial Bos taurus 109-112 10504387-2 1999 In this study the peptide sequences within or near to the terminal phosphate-binding domains of the GTP and ADP binding sites of bovine liver glutamate dehydrogenase (GDH) were identified using photoaffinity labeling with the benzophenone nucleotide derivatives, [gamma-32P]GTPgammaBP and [gamma-32P]ATPgammaBP. Adenosine Diphosphate 108-111 glutamate dehydrogenase 1, mitochondrial Bos taurus 142-165 10504387-2 1999 In this study the peptide sequences within or near to the terminal phosphate-binding domains of the GTP and ADP binding sites of bovine liver glutamate dehydrogenase (GDH) were identified using photoaffinity labeling with the benzophenone nucleotide derivatives, [gamma-32P]GTPgammaBP and [gamma-32P]ATPgammaBP. Adenosine Diphosphate 108-111 glutamate dehydrogenase 1, mitochondrial Bos taurus 167-170 10504387-5 1999 Specificity of labeling was supported by specific and effective reduction of photoinsertion of [gamma-32P]GTPgammaBP and [gamma-32P]ATPgammaBP into GDH by GTP and ADP, respectively. Adenosine Diphosphate 163-166 glutamate dehydrogenase 1, mitochondrial Bos taurus 148-151 10504387-9 1999 Using these results and the data from the previously identified base-binding domain peptides the orientation of GTP and ADP within their respective binding sites in the catalytic cleft of GDH is proposed and explained on the basis of a proposed three-dimensional schematic model structure derived from the bacterial enzyme. Adenosine Diphosphate 120-123 glutamate dehydrogenase 1, mitochondrial Bos taurus 188-191 10544922-2 1999 We have recently shown that concomitant intracellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 120-123 purinergic receptor P2Y12 Homo sapiens 78-83 10407161-1 1999 The human tumor suppressor Fhit protein exhibits diadenosine triphosphatase activity, hydrolyzing Ap(3)A to AMP and ADP. Adenosine Diphosphate 116-119 fragile histidine triad diadenosine triphosphatase Homo sapiens 27-31 10216081-9 1999 GATA-1-deficient platelets show abnormal ultrastructure, reminiscent of the megakaryocytes from which they are derived, and exhibit modest but selective defects in platelet activation in response to thrombin or to the combination of adenosine diphosphate (ADP) and epinephrine. Adenosine Diphosphate 233-254 GATA binding protein 1 Mus musculus 0-6 10216081-9 1999 GATA-1-deficient platelets show abnormal ultrastructure, reminiscent of the megakaryocytes from which they are derived, and exhibit modest but selective defects in platelet activation in response to thrombin or to the combination of adenosine diphosphate (ADP) and epinephrine. Adenosine Diphosphate 256-259 GATA binding protein 1 Mus musculus 0-6 10375966-3 1999 In our study, platelets in whole blood bound to PAC-1 when activated by a wide range of ADP concentrations. Adenosine Diphosphate 88-91 dual specificity phosphatase 2 Homo sapiens 48-53 10375966-4 1999 ADP-induced PAC-1 binding to platelets was suppressed in individuals who had taken an oral antiplatelet drug, ticlopidine. Adenosine Diphosphate 0-3 dual specificity phosphatase 2 Homo sapiens 12-17 10375966-6 1999 Platelet activation and its suppression by antiplatelet therapy may be evaluated by using ADP-induced PAC-1 binding in many clinical settings where platelet hyperreactivity and/or circulating activated platelets play a role. Adenosine Diphosphate 90-93 dual specificity phosphatase 2 Homo sapiens 102-107 10204114-14 1999 A PHHI mutation, G1479R, in the second NBF of SUR1 forms active KATP channels that respond normally to ATP, but fail to activate with MgADP. Adenosine Diphosphate 134-139 ATP binding cassette subfamily C member 8 Homo sapiens 46-50 10217423-1 1999 The ADP(Mg2+)-deactivated, azide-trapped F0 x F1-ATPase of coupled submitochondrial particles is capable of ATP synthesis being incapable of ATP hydrolysis and ATP-dependent delta muH+ generation [FEBS Lett. Adenosine Diphosphate 4-7 dynein axonemal heavy chain 8 Homo sapiens 49-55 10217423-8 1999 The energy-dependent conversion of the enzyme into latent uncoupler-activated ATPase was prevented by free ADP (Ki approximately 20 microM) and was greatly enhanced after multiple turnovers in oxidative phosphorylation. Adenosine Diphosphate 107-110 dynein axonemal heavy chain 8 Homo sapiens 78-84 10085115-4 1999 Fluorescence measurements have shown that Thr160 phosphorylation increases the affinity of CDK2 for both histone substrate and ATP and decreases its affinity for ADP. Adenosine Diphosphate 162-165 cyclin dependent kinase 2 Homo sapiens 91-95 10216964-1 1999 The hydrolysis of ATP, ADP or GTP was characterized in mitochondria and submitochondrial particles since a tightly-bound ATPase associated with the inner mitochondrial membrane from the human placenta has been described. Adenosine Diphosphate 23-26 dynein axonemal heavy chain 8 Homo sapiens 121-127 10216964-9 1999 Native gel electrophoresis showed two bands hydrolyzing ADP, suggesting at least two enzymes involved in the hydrolysis of nucleotides, besides the F1F0-ATPase. Adenosine Diphosphate 56-59 dynein axonemal heavy chain 8 Homo sapiens 153-159 9914505-1 1999 Mouse T-cell antigens Rt6.1 and Rt6.2 are glycosylphosphatidylinositol-anchored arginine-specific adenosine diphosphate (ADP)-ribosyltransferases. Adenosine Diphosphate 121-124 ADP-ribosyltransferase 2a Mus musculus 22-27 9852136-6 1998 Wild type HA-p190 induced a phenotype of rounded cells with long, beaded extensions similar to that seen when Rho function is disrupted by ADP-ribosylation. Adenosine Diphosphate 139-142 contactin associated protein 1 Homo sapiens 13-17 9873589-1 1998 Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesized with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Adenosine Diphosphate 94-97 phosphoglycerate kinase Saccharomyces cerevisiae S288C 30-53 9873589-1 1998 Stable bisubstrate ligands of phosphoglycerate kinase (PGK) have been synthesized with AMP or ADP conjugated to hydrolytically-stable, symmetrical analogues of 1,3-bisphosphoglycerate and their binding to yeast PGK evaluated. Adenosine Diphosphate 94-97 phosphoglycerate kinase Saccharomyces cerevisiae S288C 55-58 9694836-9 1998 The ADF-facilitated nucleation of ADP.actin self-assembly indicates that ADF stabilizes lateral interactions in the filament. Adenosine Diphosphate 34-37 destrin, actin depolymerizing factor Homo sapiens 4-7 9694836-9 1998 The ADF-facilitated nucleation of ADP.actin self-assembly indicates that ADF stabilizes lateral interactions in the filament. Adenosine Diphosphate 34-37 destrin, actin depolymerizing factor Homo sapiens 73-76 9581870-19 1998 The reported binding of amino-terminal Src oligopeptide to p32 ADP/ATP carrier in the mitochondrial inner membrane raises the question of its possible involvement in mitochondria-regulated mineralization. Adenosine Diphosphate 63-66 inhibitor of growth family member 2 Homo sapiens 59-62 9614197-4 1998 The trinitrophenyl analogs of ATP, ADP, AMP, and GTP produced a reversible inhibition of ATP-evoked currents in human embryonic kidney 293 cells expressing P2X1 receptors, P2X3 receptors, or both P2X2 and P2X3 (heteromeric) receptors; IC50 values were close to 1 nM. Adenosine Diphosphate 35-38 purinergic receptor P2X 3 Homo sapiens 172-176 9614197-4 1998 The trinitrophenyl analogs of ATP, ADP, AMP, and GTP produced a reversible inhibition of ATP-evoked currents in human embryonic kidney 293 cells expressing P2X1 receptors, P2X3 receptors, or both P2X2 and P2X3 (heteromeric) receptors; IC50 values were close to 1 nM. Adenosine Diphosphate 35-38 purinergic receptor P2X 3 Homo sapiens 205-209 9525878-8 1998 Thus, the modulation of the 2-OGDH activity by Mg2+ has an essential requirement for Pi (and ADP) in intact mitochondria which is not associated to variations in matrix pH. Adenosine Diphosphate 93-96 oxoglutarate dehydrogenase Rattus norvegicus 30-34 9510525-8 1998 The oxygen affinity in the active ADP-stimulated state is higher in mitochondria from heart than in those from liver, in direct relationship to the higher excess capacity of COX in heart. Adenosine Diphosphate 34-37 cytochrome c oxidase subunit 8A Homo sapiens 174-177 9547364-6 1998 ADP derivatives were removed from the solution by treatment with CP/CPK. Adenosine Diphosphate 0-3 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 68-71 11324534-0 1998 [Effect of Arg-Gly-Asp-Ser (RGDS) peptide on ADP-induced signal transduction of activated rat platelet]. Adenosine Diphosphate 45-48 ral guanine nucleotide dissociation stimulator Rattus norvegicus 28-32 11324534-4 1998 When platelets and ADP were incubated together with 50, 100, 200 mumol/L RGDS peptide it was found that the latter markedly inhibited ADP activated platelet aggregation and activation of PKC and MAPK, both in a concentration-dependently manner. Adenosine Diphosphate 19-22 ral guanine nucleotide dissociation stimulator Rattus norvegicus 73-77 11324534-4 1998 When platelets and ADP were incubated together with 50, 100, 200 mumol/L RGDS peptide it was found that the latter markedly inhibited ADP activated platelet aggregation and activation of PKC and MAPK, both in a concentration-dependently manner. Adenosine Diphosphate 134-137 ral guanine nucleotide dissociation stimulator Rattus norvegicus 73-77 11324534-6 1998 The above result suggested that the antithrombotic effect of RGDS peptide was probably mediated through its effect on intracellular signal transduction in the ADP activation of platelets. Adenosine Diphosphate 159-162 ral guanine nucleotide dissociation stimulator Rattus norvegicus 61-65 9563830-0 1998 Extramitochondrial ATP/ADP-ratios regulate cytochrome c oxidase activity via binding to the cytosolic domain of subunit IV. Adenosine Diphosphate 23-26 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 43-63 9563830-1 1998 Cytochrome c oxidase from bovine heart contains seven binding sites for ATP or ADP and three additional for ADP only, as concluded from competition equilibrium dialysis binding studies. Adenosine Diphosphate 79-82 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 0-20 9563830-1 1998 Cytochrome c oxidase from bovine heart contains seven binding sites for ATP or ADP and three additional for ADP only, as concluded from competition equilibrium dialysis binding studies. Adenosine Diphosphate 108-111 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 0-20 9563830-4 1998 The Km for cytochrome c is five times higher in the presence of extraliposomal ATP than of ADP. Adenosine Diphosphate 91-94 LOC104968582 Bos taurus 11-23 9563830-6 1998 The data demonstrate regulation of cytochrome c oxidase activity by the cytosolic ATP/ADP-ratio, in addition to regulation by the matrix ATP/ADP-ratio [Arnold and Kadenbach (1997) Eur. Adenosine Diphosphate 86-89 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 35-55 9442017-0 1998 Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. Adenosine Diphosphate 29-32 Rud3p Saccharomyces cerevisiae S288C 14-18 9459569-3 1998 5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by gamma-mangostin (IC50 = 0.29 microM), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists. Adenosine Diphosphate 16-19 5-hydroxytryptamine receptor 2A Rattus norvegicus 61-67 9428522-4 1997 The hMSH2-hMSH6 complex is ON (binds mismatched nucleotides) in the ADP-bound form and OFF in the ATP-bound form. Adenosine Diphosphate 68-71 mutS homolog 2 Homo sapiens 4-9 9398336-14 1997 In the competition for AAC2 transport capacity, the weak ATP exporting modes are suppressed by the much stronger unproductive ADP/ADP mode causing inhibition of OxPhos. Adenosine Diphosphate 126-129 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 23-27 9398336-14 1997 In the competition for AAC2 transport capacity, the weak ATP exporting modes are suppressed by the much stronger unproductive ADP/ADP mode causing inhibition of OxPhos. Adenosine Diphosphate 130-133 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 23-27 9523019-1 1997 The adhesion of ADP-stimulated platelets to immobilized fibrinogen induces the tyrosine phosphorylation of multiple proteins which include pp72syk and pp125FAK. Adenosine Diphosphate 16-19 protein tyrosine kinase 2 Homo sapiens 151-159 9398666-0 1997 Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Adenosine Diphosphate 70-73 transforming protein RhoA Oryctolagus cuniculus 14-18 24976516-0 2014 mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model. Adenosine Diphosphate 28-31 mechanistic target of rapamycin kinase Rattus norvegicus 0-4 9398666-5 1997 We conclude that RhoA plays a significant role in G-protein-, but not protein kinase C-mediated, Ca2+ sensitization and that ADP ribosylation inhibits in vivo the Ca2+-sensitizing effect of RhoA by interfering with its binding to a membrane-associated effector. Adenosine Diphosphate 125-128 transforming protein RhoA Oryctolagus cuniculus 190-194 9397682-1 1997 ATP synthase (F0F1-ATPase) uses proton- or sodium-motive force to produce ATP form ADP and P(i). Adenosine Diphosphate 83-86 ATP synthase F1 subunit epsilon Homo sapiens 14-25 9285593-2 1997 Productive folding of the substrate rhodanese has been observed in cis ternary complexes, where GroES and polypeptide are bound to the same ring, formed with either ATP, ADP or non-hydrolysable ATP analogues, suggesting that the specific requirement for ATP is confined to an action in the trans ring that evicts GroES and polypeptide from the cis side. Adenosine Diphosphate 170-173 heat shock protein family E (Hsp10) member 1 Homo sapiens 96-101 24976516-9 2014 GFAP and mTOR expression in the rat spinal dorsal horn on post-surgical day 14 was enhanced by daily intrathecal injection of ADP, which was inhibited by rapamycin. Adenosine Diphosphate 126-129 glial fibrillary acidic protein Rattus norvegicus 0-4 24976516-9 2014 GFAP and mTOR expression in the rat spinal dorsal horn on post-surgical day 14 was enhanced by daily intrathecal injection of ADP, which was inhibited by rapamycin. Adenosine Diphosphate 126-129 mechanistic target of rapamycin kinase Rattus norvegicus 9-13 9251811-12 1997 MgADP, for both S1(elc, rlc) and S1(elc). Adenosine Diphosphate 0-5 C-C motif chemokine ligand 19 Homo sapiens 19-22 24019084-6 2014 CD41-platelet expression, however, was significantly increased in patients with KD compared with controls, both at rest (14.3 +- 1.9 vs 12.4 +- 1.9 mean fluorescence intensity [mfi], P = .01) and after adenosine diphosphate stimulation (19.3 +- 1.3 vs 17 +- 1.7 mfi, P < .001). Adenosine Diphosphate 202-223 integrin subunit alpha 2b Homo sapiens 0-4 9251811-12 1997 MgADP, for both S1(elc, rlc) and S1(elc). Adenosine Diphosphate 0-5 C-C motif chemokine ligand 19 Homo sapiens 33-40 9237899-5 1997 Mge1 has no direct effect on gamma-phosphate release from mtHsp70, yet indirectly relieves the phosphate inhibition by stimulating ADP release. Adenosine Diphosphate 131-134 Mge1p Saccharomyces cerevisiae S288C 0-4 9237899-6 1997 We conclude that Mge1 promotes the ATPase cycle of mtHsp70 by increasing the rate of ADP release. Adenosine Diphosphate 85-88 Mge1p Saccharomyces cerevisiae S288C 17-21 9099720-6 1997 Membrane-associated rhoA in unstimulated portal vein was a good substrate for in vitro ADP-ribosylation, whereas the large amount translocated by GTPgammaS was not. Adenosine Diphosphate 87-90 transforming protein RhoA Oryctolagus cuniculus 20-24 24731293-7 2014 In contrast, HNP levels correlated significantly with adenosine diphosphate (ADP)-inducible neutrophil-platelet aggregate formation (r = 0.13, P = 0.04). Adenosine Diphosphate 54-75 kallikrein related peptidase 8 Homo sapiens 13-16 9092805-3 1997 (1995) Biochemistry 34, 8960-8972] that in one of the important transitions of myosin head (M), M x ATP --> M x ADP x Pi, a rotation occurs in Gly468 (of chicken smooth muscle myosin). Adenosine Diphosphate 115-118 myosin, heavy chain 15 Gallus gallus 79-85 9092805-3 1997 (1995) Biochemistry 34, 8960-8972] that in one of the important transitions of myosin head (M), M x ATP --> M x ADP x Pi, a rotation occurs in Gly468 (of chicken smooth muscle myosin). Adenosine Diphosphate 115-118 myosin, heavy chain 15 Gallus gallus 179-185 24731293-7 2014 In contrast, HNP levels correlated significantly with adenosine diphosphate (ADP)-inducible neutrophil-platelet aggregate formation (r = 0.13, P = 0.04). Adenosine Diphosphate 77-80 kallikrein related peptidase 8 Homo sapiens 13-16 24731293-11 2014 In conclusion, HNP levels are associated with ADP-inducible neutrophil-platelet aggregate formation and clopidogrel-mediated platelet inhibition. Adenosine Diphosphate 46-49 kallikrein related peptidase 8 Homo sapiens 15-18 9020154-4 1997 Mouse Rt6.1 (mRt6.1) also catalyzes auto-ADP-ribosylation. Adenosine Diphosphate 41-44 ADP-ribosyltransferase 2a Mus musculus 6-9 24949858-4 2014 A crystal structure of the ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket, as if ready to exchange its bound ADP for Mg ATP. Adenosine Diphosphate 27-30 kinesin family member 14 Homo sapiens 49-54 9020154-4 1997 Mouse Rt6.1 (mRt6.1) also catalyzes auto-ADP-ribosylation. Adenosine Diphosphate 41-44 ADP-ribosyltransferase 2a Mus musculus 13-19 9020154-5 1997 The activity of mouse cytotoxic T lymphocytes is reportedly inhibited by ADP-ribosylation of surface proteins, raising the possibility that mRt6 may participate in this process. Adenosine Diphosphate 73-76 ADP-ribosyltransferase 2a Mus musculus 140-144 9020154-8 1997 mRt6.1, but not rat RT6.2, catalyzed the ADP-ribosylation of guanidino-containing compounds (e.g. agmatine). Adenosine Diphosphate 41-44 ADP-ribosyltransferase 2a Mus musculus 0-6 24949858-4 2014 A crystal structure of the ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket, as if ready to exchange its bound ADP for Mg ATP. Adenosine Diphosphate 152-155 kinesin family member 14 Homo sapiens 49-54 9048947-3 1997 The release of both ATP and ADP from Ssc1 was stimulated in the presence of Mge1, therefore we conclude that Mge1 functions as a nucleotide release factor for Ssc1. Adenosine Diphosphate 28-31 Mge1p Saccharomyces cerevisiae S288C 76-80 24928315-13 2014 RhoA ADP-ribosylation induced by C3 was confirmed by Western blot. Adenosine Diphosphate 5-8 ras homolog family member A Rattus norvegicus 0-4 9048947-3 1997 The release of both ATP and ADP from Ssc1 was stimulated in the presence of Mge1, therefore we conclude that Mge1 functions as a nucleotide release factor for Ssc1. Adenosine Diphosphate 28-31 Mge1p Saccharomyces cerevisiae S288C 109-113 9048947-5 1997 ADP was much less effective in releasing Mge1 from Ssc1 whereas ATP gamma S and AMPPNP could not disrupt the Ssc1/Mge1 complex. Adenosine Diphosphate 0-3 Mge1p Saccharomyces cerevisiae S288C 41-45 24782221-7 2014 A multivariate analysis showed that the effect of CYP2C19*2 allele on an ADP-induced platelet aggregation was better pronounced in the presence of non-genetic risk factors (P = 0.008). Adenosine Diphosphate 73-76 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 50-57 9003796-6 1997 These results suggest that a stable inhibitory complex MRP x MgADP x Vi, an analog of the MRP x MgADP x Pi transition state complex, is formed in the presence of vanadate. Adenosine Diphosphate 61-66 ATP binding cassette subfamily C member 3 Homo sapiens 55-58 9003796-6 1997 These results suggest that a stable inhibitory complex MRP x MgADP x Vi, an analog of the MRP x MgADP x Pi transition state complex, is formed in the presence of vanadate. Adenosine Diphosphate 61-66 ATP binding cassette subfamily C member 3 Homo sapiens 90-93 8995221-2 1997 In these circumstances, GroES could only partially discharge the DHFR if ADP was present in the solution and approximately half of the DHFR remained bound on the chaperonin. Adenosine Diphosphate 73-76 heat shock protein family E (Hsp10) member 1 Homo sapiens 24-29 9193670-9 1997 We have found that soluble desmin is present in 5-6 day myogenic cell cultures and that this desmin contains ADP-ribose, demonstrating that desmin is ADP-ribosylated in skeletal muscle cells. Adenosine Diphosphate 109-112 desmin Gallus gallus 93-99 9193670-9 1997 We have found that soluble desmin is present in 5-6 day myogenic cell cultures and that this desmin contains ADP-ribose, demonstrating that desmin is ADP-ribosylated in skeletal muscle cells. Adenosine Diphosphate 109-112 desmin Gallus gallus 93-99 8996509-7 1997 Pretreatment of cerebral arterioles with the specific CGRP1 receptor antagonist CGRP-(8-37) (5 x 10(-7) mol/L) selectively inhibited the vasodilator responses to adrenomedullin without inhibiting responses to ADP (10(-5) to 10(-3) mol/L). Adenosine Diphosphate 209-212 calcitonin-related polypeptide alpha Rattus norvegicus 54-58 8955274-6 1996 Here we report that Tim22 is required for the import of proteins of the mitochondrial ADP/ATP carrier (AAC) family into the inner membrane. Adenosine Diphosphate 86-89 translocation channel protein TIM22 Saccharomyces cerevisiae S288C 20-25 8947033-3 1996 We find that GroEL-bound substrate polypeptide can induce GroES cycling on and off GroEL in the presence of ADP. Adenosine Diphosphate 108-111 heat shock protein family E (Hsp10) member 1 Homo sapiens 58-63 8945937-1 1996 The purpose of this study was to evaluate the relative contributions of AMP-specific cytosolic 5"-nucleotidase and ecto-5"-nucleotidase to cardiac adenosine production and its regulation by ADP and Mg2+. Adenosine Diphosphate 190-193 5'-nucleotidase ecto Canis lupus familiaris 95-110 8945937-4 1996 ADP, (20-480 mumol/l) activated supernatant and inhibited membrane-bound 5"-nucleotidase activity. Adenosine Diphosphate 0-3 5'-nucleotidase ecto Canis lupus familiaris 73-88 8945937-7 1996 These findings support the hypotheses that 1) both cytosolic and ecto-5"-nucleotidase contribute to cardiac adenosine production in dog heart homogenates; 2) AMP-specific cytosolic 5"-nucleotidase activity exceeds ecto-5"-nucleotidase activity at physiological concentrations of ADP, AMP, and Mg2+; and 3) Mg2+ is an important regulator of cardiac adenosine production via activation of both ecto- and AMP-specific cytosolic 5"-nucleotidases. Adenosine Diphosphate 279-282 5'-nucleotidase ecto Canis lupus familiaris 181-196 8945937-7 1996 These findings support the hypotheses that 1) both cytosolic and ecto-5"-nucleotidase contribute to cardiac adenosine production in dog heart homogenates; 2) AMP-specific cytosolic 5"-nucleotidase activity exceeds ecto-5"-nucleotidase activity at physiological concentrations of ADP, AMP, and Mg2+; and 3) Mg2+ is an important regulator of cardiac adenosine production via activation of both ecto- and AMP-specific cytosolic 5"-nucleotidases. Adenosine Diphosphate 279-282 5'-nucleotidase ecto Canis lupus familiaris 181-196 8918457-5 1996 Mge1p is then required for the dissociation of the ADP form of mt-Hsp70 from Tim44 after release of inorganic phosphate but before release of ADP. Adenosine Diphosphate 51-54 Mge1p Saccharomyces cerevisiae S288C 0-5 8918457-5 1996 Mge1p is then required for the dissociation of the ADP form of mt-Hsp70 from Tim44 after release of inorganic phosphate but before release of ADP. Adenosine Diphosphate 142-145 Mge1p Saccharomyces cerevisiae S288C 0-5 8918457-7 1996 Subsequently, the release of mt-Hsp70 from the polypeptide chain is triggered by Mge1p which promotes release of ADP from mt-Hsp70. Adenosine Diphosphate 113-116 Mge1p Saccharomyces cerevisiae S288C 81-86 8917426-5 1996 In contrast to the previously reported reversibility of many tyrosine kinase reactions, the tyrosine phosphorylation of Xenopus MAPK was found to be irreversible in the presence of high ADP concentrations, although ADP could competitively inhibit both autophosphorylation and myelin basic protein phosphorylation. Adenosine Diphosphate 215-218 myelin basic protein S homeolog Xenopus laevis 276-296 8810904-6 1996 The Trp fluorescence of a single Trp SecA mutant containing Trp775 decreased and increased upon the addition of NBS-I saturating concentrations of ADP or AMP-PNP, respectively. Adenosine Diphosphate 147-150 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 112-115 8810904-8 1996 Binding of ADP to NBS-I increased the interaction between the two domains whereas binding of AMP-PNP did not influence this interaction. Adenosine Diphosphate 11-14 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 18-21 8660950-9 1996 Our results showed that incorporation of isotope into this protein band from [32P]NAD is due to ADP-ribosylation of desmin. Adenosine Diphosphate 96-99 desmin Gallus gallus 116-122 8630086-6 1996 All the non-hydrolysable analogues tested, except alpha,beta-metADP, competed with ATP and ADP for the ATPDase catalytic site, reducing their hydrolysis by 35-50%. Adenosine Diphosphate 64-67 ectonucleoside triphosphate diphosphohydrolase 1 Bos taurus 103-110 8630086-8 1996 These results strongly support the view that (1) the ATPDase is expected to reduce substantially the P2-response induced by ATP, ADP, and some hydrolysable agonists; and (2) by competing with the hydrolysis of endogenously released ATP and ADP, non-hydrolysable analogues could alter the amplitude or direction of the cellular response induced by these natural substrates. Adenosine Diphosphate 129-132 ectonucleoside triphosphate diphosphohydrolase 1 Bos taurus 53-60 8630086-8 1996 These results strongly support the view that (1) the ATPDase is expected to reduce substantially the P2-response induced by ATP, ADP, and some hydrolysable agonists; and (2) by competing with the hydrolysis of endogenously released ATP and ADP, non-hydrolysable analogues could alter the amplitude or direction of the cellular response induced by these natural substrates. Adenosine Diphosphate 240-243 ectonucleoside triphosphate diphosphohydrolase 1 Bos taurus 53-60 8679553-0 1996 Conformation of manganese(II)-nucleotide complexes bound to rabbit muscle creatine kinase: 13C NMR measurements using [2-13C]ATP and [2-13C]ADP. Adenosine Diphosphate 140-143 creatine kinase M-type Oryctolagus cuniculus 67-89 8679553-1 1996 Conformations of cation-nucleotide complexes bound to rabbit muscle creatine kinase were investigated by measuring paramagnetic effects on 13C spin relaxation in E.Mn[2-13C]ATP and E.Mn[2-13C]ADP at three different frequencies, viz., 50, 75, and 125 MHz, and as a function of temperature in the range of 7-35 degrees C (at 75 MHz). Adenosine Diphosphate 192-195 creatine kinase M-type Oryctolagus cuniculus 61-83 8816952-0 1996 Identification of adenine binding domain peptides of the ADP regulatory site within glutamate dehydrogenase. Adenosine Diphosphate 57-60 glutamate dehydrogenase 1, mitochondrial Bos taurus 84-107 8816952-2 1996 In the absence of UV irradiation, 8N3ADP was able to activate the reverse reaction catalyzed by GDH as well as ADP. Adenosine Diphosphate 37-40 glutamate dehydrogenase 1, mitochondrial Bos taurus 96-99 8611524-5 1996 Although ADP can support the AlF inhibition, the rate of inhibition is more than 30-fold greater with ATP, which suggests the reactive conformation more closely resembles ATP hydrolysis. Adenosine Diphosphate 9-12 afamin Homo sapiens 29-32 8613950-5 1996 V3 and P/O (ratio corresponds to the number of ADP molecules added in the medium per oxygen atom consumed during phosphorylation and represents the yield of ATP synthesis) were simultaneously decreased by CsA (1 microM) and restored by TMZ. Adenosine Diphosphate 47-50 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 205-208 8631786-7 1996 The phosphorylation of Vav in response to thrombin was maximal within 15 s and was unaffected by aspirin, inhibitors of aggregation, or the presence of the ADP scavenger, apyrase. Adenosine Diphosphate 156-159 vav guanine nucleotide exchange factor 1 Homo sapiens 23-26 8709006-5 1996 Islet-activating protein (IAP, pertussis toxin, PTX) catalyses the transfer of the ADP-ribose moiety of NAD to the alpha subunit of Gi, resulting in a complete loss of the Gi functions. Adenosine Diphosphate 83-86 islet amyloid polypeptide Homo sapiens 0-24 8709006-5 1996 Islet-activating protein (IAP, pertussis toxin, PTX) catalyses the transfer of the ADP-ribose moiety of NAD to the alpha subunit of Gi, resulting in a complete loss of the Gi functions. Adenosine Diphosphate 83-86 islet amyloid polypeptide Homo sapiens 26-29 8608229-12 1996 Both TRAP and ADP/epinephrine redistributed platelet surface GPIb, GPIX, and GPV to the SCCS. Adenosine Diphosphate 14-17 glycoprotein IX platelet Homo sapiens 67-71 25161822-10 2014 In vitro studies show that nucleosome-bound PARP1 disrupts nucleosome structure histone ADP-ribosylation, increasing the accessibility of nucleosomal DNA. Adenosine Diphosphate 88-91 poly (ADP-ribose) polymerase family, member 1 Mus musculus 44-49 8537444-2 1995 Adenosine diphosphate also produces a pHi decrease, but adenosine monophosphate, uridine triphosphate, 2-methylthio-ATP, and beta, gamma-methylene-ATP have little effect on pHi. Adenosine Diphosphate 0-21 glucose-6-phosphate isomerase Homo sapiens 38-41 7602094-4 1995 We found that partial ADP-ribosylation of the Gi2/Gi3 proteins before stimulation with IL-1 was sufficient to obtain full inhibition of IL-2 release. Adenosine Diphosphate 22-25 interleukin 1 complex Mus musculus 87-91 7776367-7 1995 Stimulation of the gamma-phosphate cleavage reaction by DnaJ is much more efficient (complete conversion of bound ATP to ADP within five seconds) than that by substrates, indicating the special and important role for DnaJ in stabilization of DnaK-substrate interactions. Adenosine Diphosphate 121-124 ATPase Escherichia coli 114-117 7649708-7 1995 Main function of this ATP regeneration is to keep the local ADP/ATP ratios favorable for ATPase function, which seems to be especially important when ATPase turnover is high. Adenosine Diphosphate 60-63 dynein axonemal heavy chain 8 Homo sapiens 89-95 7649708-7 1995 Main function of this ATP regeneration is to keep the local ADP/ATP ratios favorable for ATPase function, which seems to be especially important when ATPase turnover is high. Adenosine Diphosphate 60-63 dynein axonemal heavy chain 8 Homo sapiens 150-156 7827022-5 1995 At variable alpha i3C20, C204- and rS1-catalyzed ADP-ribosylation followed Michaelis-Menten kinetics, while the velocity curve generated by C180 diverged from Michaelis-Menten kinetics. Adenosine Diphosphate 49-52 retinoschisin 1 Rattus norvegicus 35-38 7798951-3 1995 The maximal rise in cyclic GMP level achieved was highest for ATP and decreased in the following order: ATP = adenosine 5"(gamma-thio)triphosphate > UTP = 2-methylthio-ATP > ADP much greater than CTP, AMP, alpha,beta-methylene-ATP, 2"- and 3"-O-(4-benzoylbenzoyl)ATP. Adenosine Diphosphate 180-183 5'-nucleotidase, cytosolic II Mus musculus 27-30 8904203-2 1995 Since the P2T receptor seems to be specific to platelets, we investigated the possibility that the human megakaryoblastic cell line Meg-01 might express the platelet ADP receptor, using functional studies and the ADP analogue [33P]2MeSADP as a specific P2T radioligand. Adenosine Diphosphate 166-169 protein tyrosine phosphatase non-receptor type 4 Homo sapiens 132-135 8904203-3 1995 ADP and 2MeSADP were able to induce shape change and pseudopod formation in Meg-01 cells. Adenosine Diphosphate 0-3 protein tyrosine phosphatase non-receptor type 4 Homo sapiens 76-79 8904203-7 1995 Desensitization experiments demonstrated that UTP, and ADP share a common P2U purinoceptor and that Meg-01 cells also express a P2T purinoceptor for which ADP and 2MeSADP are agonists and ATP a competitive antagonist. Adenosine Diphosphate 155-158 protein tyrosine phosphatase non-receptor type 4 Homo sapiens 100-103 21043698-5 1995 In aspirinated platelets in the presence of creatine phosphate/creatine phosphokinase (CP/CPK) to remove secreted ADP, increasing concentrations of NO still produced strong inhibition of [(32)P] PA-formation and secretory responses. Adenosine Diphosphate 114-117 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 44-93 7725803-7 1994 Mcm2, a protein important for ARS activity, as well as Aac2, one of the three isoforms of the mitochondrial ATP/ADP carrier, were previously described (Yan et al., 1991; Lawson and Douglas, 1988). Adenosine Diphosphate 112-115 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 55-59 7767879-5 1994 This high membrane ATPase activity will cause a gradient of ATP into and ADP out of the bundle of cells. Adenosine Diphosphate 73-76 dynein axonemal heavy chain 8 Homo sapiens 19-25 7767879-6 1994 Thus modulation of this ATPase by G-protein-receptor mechanisms could alter the force at a constant Ca2+ concentration by changing the ADP/ATP ratio within the cells. Adenosine Diphosphate 135-138 dynein axonemal heavy chain 8 Homo sapiens 24-30 8075144-7 1994 ADP-binding induces conformational changes in the ATPase polypeptide backbone with alpha-helical structures and presumably beta-sheet or beta-turn structures involved. Adenosine Diphosphate 0-3 dynein axonemal heavy chain 8 Homo sapiens 50-56 7963069-1 1994 Pertussis toxin (islet-activating protein, IAP) sensitive guanine nucleotide-binding regulatory (G) proteins were quantitatively determined using [32P]ADP-ribosylating response in the platelet membranes prepared from patients with affective disorders (3 bipolar, 10 major depression) and sex- and age-matched controls. Adenosine Diphosphate 151-154 islet amyloid polypeptide Homo sapiens 43-46 7963069-2 1994 IAP-catalyzed [32P]ADP-ribosylation was not significantly different between patients and controls, suggesting that the quantity of IAP-sensitive G proteins is unaltered in affective disorder patients. Adenosine Diphosphate 19-22 islet amyloid polypeptide Homo sapiens 0-3 8147877-4 1994 Both helicase-primase and UL9 protein ATPase activities were inhibited by ADP or GDP; this effect was competitive rather than allosteric. Adenosine Diphosphate 74-77 dynein axonemal heavy chain 8 Homo sapiens 38-44 8200911-9 1994 However, a monoclonal antibody to the insulin receptor (MA-20) at equimolar concentrations with insulin equally inhibits pertussis toxin-catalyzed ADP ribosylation of Gi without activating tyrosine kinase or insulin receptor autophosphorylation. Adenosine Diphosphate 147-150 insulin receptor Homo sapiens 38-54 8279516-1 1993 Creatine kinase (CK) is normally found at high levels in muscle and brain and catalyzes the reaction phosphocreatine (PCr) + MgADP + H+<==>creatine (Cr) + MgATP. Adenosine Diphosphate 125-130 creatine kinase, brain Mus musculus 17-19 8138530-3 1993 This suggests that the two kinds of cross-linked species have almost the same ATPase activity, and that the cross-linking at these different sites nearly equally facilitates the formation of the strong binding state which accompanies the release of ADP and Pi. Adenosine Diphosphate 249-252 dynein axonemal heavy chain 8 Homo sapiens 78-84 8219223-6 1993 PGE2 (5 to 500 nmol/L) significantly enhanced secretion of beta-thromboglobulin (beta TG) and adenosine triphosphate from U46619- and ADP-stimulated platelets, but it did not affect platelet shape change. Adenosine Diphosphate 134-137 pro-platelet basic protein Homo sapiens 59-79 8399168-5 1993 Complex formation is demonstrated between ADF and actin containing either ATP, ADP, or AMPPNP as the bound nucleotide. Adenosine Diphosphate 79-82 destrin, actin depolymerizing factor Gallus gallus 42-45 8396441-3 1993 Participation of myosin-ATPase in binding of ADP within cells as it was supposed earlier (Saks, V.A., Belikova, Yu.O. Adenosine Diphosphate 45-48 dynein axonemal heavy chain 8 Homo sapiens 24-30 8485140-7 1993 Activation of platelets with ADP or thrombin reduced Lp(a) binding capacity by approximately 50% without changing affinity. Adenosine Diphosphate 29-32 lipoprotein(a) Homo sapiens 53-58 8381725-4 1993 Ex vivo studies on platelet aggregation response to ADP and PAF performed on platelet-rich plasma obtained before and after SK and t-PA infusion demonstrated an early hyperaggregable phase, abrogated by PAF receptor antagonists and followed by reduced sensitivity of platelets to PAF. Adenosine Diphosphate 52-55 platelet-activating factor receptor Oryctolagus cuniculus 203-215 24418943-10 2014 Platelet aggregation with ADP was higher in CYP2C19*1*2 genotype carriers than in CYP2C19*1*1 carriers (P = 0.01). Adenosine Diphosphate 26-29 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 44-51 8383320-0 1993 Tissue-specific regulation of bovine heart cytochrome-c oxidase activity by ADP via interaction with subunit VIa. Adenosine Diphosphate 76-79 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 43-63 8383320-1 1993 The activity of reconstituted cytochrome-c oxidase (EC 1.9.3.1) from bovine heart is stimulated by intraliposomal ADP but not by NaCl of the same ionic strength. Adenosine Diphosphate 114-117 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 30-50 8383320-4 1993 Preincubation of heart cytochrome-c oxidase with the antibody prevents stimulation of activity by intraliposomal ADP after reconstitution in liposomes. Adenosine Diphosphate 113-116 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 23-43 8383320-6 1993 The data suggest tissue-specific regulation of the activity of cytochrome-c oxidase by ADP via interaction with the matrix domain of subunit VIa-H. Adenosine Diphosphate 87-90 cytochrome c oxidase subunit 6A1, mitochondrial Bos taurus 63-83 24418943-10 2014 Platelet aggregation with ADP was higher in CYP2C19*1*2 genotype carriers than in CYP2C19*1*1 carriers (P = 0.01). Adenosine Diphosphate 26-29 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 82-89 24637024-8 2014 ADP dissociation from the actin ATM1 complex (acto-ATM1) was extremely slow, which accounts for the low actin-sliding velocity, low actin-activated ATPase activity, and high duty ratio. Adenosine Diphosphate 0-3 myosin 1 Arabidopsis thaliana 32-36 8382086-6 1993 [3H]PGE2-bound EP3 receptor solubilized from the ADP-ribosylated membranes in the presence or absence of GTP gamma S was eluted at the position of M(r) = approx. Adenosine Diphosphate 49-52 prostaglandin E receptor 3 (subtype EP3) Mus musculus 15-18 8439316-2 1993 Pre-treatment of the cells with nerve growth factor inhibits this EDIN-catalyzed ADP-ribosylation, both in vitro and in vivo. Adenosine Diphosphate 81-84 nerve growth factor Rattus norvegicus 32-51 8457540-4 1993 When the dietary fat level was altered to provide (% PGE: % fat-energy): 30:14, 30:30, 70:14, 70:30, feeding 70% PGE diets reduced the ADP:O value compared with the 30% PGE level, but no difference was observed between low-fat and high-fat groups. Adenosine Diphosphate 135-138 FAT atypical cadherin 1 Rattus norvegicus 17-20 7507391-1 1993 We have determined that ADP-induced platelet aggregation and secretion are enhanced by preincubation of human platelets with the immunosuppressant cyclosporine A (CSA) (see accompanying article by Naik et al., 1993). Adenosine Diphosphate 24-27 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 163-166 7507391-3 1993 Preincubation of platelets with either CSA, CSG, or FK-506 resulted in platelets which exhibited hyperaggregability when stimulated by ADP. Adenosine Diphosphate 135-138 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 39-42 7507391-7 1993 Comparative studies performed with CSA and CSG indicated that a short preincubation period with CSA (2.5 min) resulted in a 90% enhancement of ADP-induced platelet aggregation, whereas CSG enhancement was only 20%. Adenosine Diphosphate 143-146 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 96-99 7507391-8 1993 At a concentration of 600 ng/ml, CSA produced 120% enhancement of ADP-induced platelet aggregation, whereas CSG produced only a 30% enhancement. Adenosine Diphosphate 66-69 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 33-36 7507391-10 1993 Determination of the binding of two radiolabeled probes directed against the fibrinogen receptor, fibrinogen itself, and a monoclonal antibody (M.Ab.G10) revealed that the binding of fibrinogen to ADP-stimulated platelets was enhanced by 50% following the preincubation of platelets with 600 ng/ml CSA. Adenosine Diphosphate 197-200 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 298-301 7507391-13 1993 Preincubation of platelets with 600 ng/ml CSA or CSG resulted in 60% and 30% increase in total protein kinase C activity, respectively, following the addition of ADP. Adenosine Diphosphate 162-165 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 42-45 7507391-14 1993 In conclusion, this study has determined that preincubation of platelets with CSA or FK-506 (CSG, to a smaller extent) results in significant enhancement of ADP-induced platelet aggregation and secretion. Adenosine Diphosphate 157-160 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 78-81 8502126-0 1993 Neuropeptide Y inhibits pertussis toxin-catalyzed ADP-ribosylation in bovine adrenal chromaffin cell membranes. Adenosine Diphosphate 50-53 neuropeptide Y Bos taurus 0-14 8502126-4 1993 Preincubation of the plasma membranes with high concentrations of neuropeptide Y followed by a brief exposure to a low concentration of 5"-guanylylimidodiphosphate significantly inhibited ADP-ribosylation beyond that observed with 5"-guanylylimidodiphosphate alone. Adenosine Diphosphate 188-191 neuropeptide Y Bos taurus 66-80 1333649-6 1992 Neutrophil elastase potentiation of platelet responses induced by low concentrations of cathepsin G was markedly inhibited by creatine phosphate/creatine phosphokinase and/or indomethacin, indicating that the synergism between elastase and cathepsin G required the participation of ADP and thromboxane A2. Adenosine Diphosphate 282-285 elastase, neutrophil expressed Homo sapiens 0-19 1385393-1 1992 When the catalytically active, tyrosyl-phosphorylated form of insulin receptor was isolated from human placenta and treated with ADP, only partial dephosphorylation was observed. Adenosine Diphosphate 129-132 insulin receptor Homo sapiens 62-78 1385393-2 1992 This observation suggests the existence of two distinct classes of phosphotyrosyl residues of the phosphorylated insulin receptor: one in which the phosphoryl groups undergo reversible transfer to ADP and one in which they do not. Adenosine Diphosphate 197-200 insulin receptor Homo sapiens 113-129 1385393-8 1992 The dependence of the degree of phosphorylation of insulin receptor on the ATP:ADP ratio may provide a mechanism for modulating the cellular response to insulin. Adenosine Diphosphate 79-82 insulin receptor Homo sapiens 51-67 1420290-4 1992 4 h after the in vivo administration of TDGA, the CPT-I activity in saponin-permeabilized platelets was nearly completely inhibited along with a significant reduction in the MAR induced by ADP, thrombin and ionophore A23187. Adenosine Diphosphate 189-192 carnitine palmitoyltransferase 1B Rattus norvegicus 50-55 1325440-6 1992 Protease susceptibility indicated that the ADP form of BiP/Kar2 is more resistant than the ATP form to the chymotrypsin digestion and that BiP/Kar2 required the presence of ATP to avoid the irreversible denaturation. Adenosine Diphosphate 43-46 Hsp70 family ATPase KAR2 Saccharomyces cerevisiae S288C 59-63 1355374-4 1992 In whole blood, adenosine diphosphate (ADP) and the thromboxane A2 mimetic U 46619 induced the aggregation (increase in impedance) and the CL, which were both suppressed by EDTA, arginyl-glycyl-aspartyl-serine (RGDS) peptide, and the absence of stirring. Adenosine Diphosphate 16-37 ral guanine nucleotide dissociation stimulator Homo sapiens 211-215 1355374-4 1992 In whole blood, adenosine diphosphate (ADP) and the thromboxane A2 mimetic U 46619 induced the aggregation (increase in impedance) and the CL, which were both suppressed by EDTA, arginyl-glycyl-aspartyl-serine (RGDS) peptide, and the absence of stirring. Adenosine Diphosphate 39-42 ral guanine nucleotide dissociation stimulator Homo sapiens 211-215 1610912-6 1992 Addition of ATPDase to platelets pre-aggregated with ADP resulted in a dose-dependent disaggregation in platelet-rich plasma (IC50 4.9 mU/ml), but not in whole blood. Adenosine Diphosphate 53-56 ectonucleoside triphosphate diphosphohydrolase 1 Bos taurus 12-19 1384161-4 1992 LK-4 inhibits platelet aggregation induced by ADP, epinephrine, collagen and thrombin, suggesting reactivity at or near the fibrinogen binding site on GPIIIa. Adenosine Diphosphate 46-49 ceramide kinase Homo sapiens 0-4 1313365-8 1992 The time course of labelling of ADP-ribosylated EF-2 with [32P]orthophosphate was similar in pyBHK cells and in CHO-K1 cells. Adenosine Diphosphate 32-35 elongation factor 2 Cricetulus griseus 48-52 1313365-10 1992 EF-2 mutants of pyBHK and CHO-K1 cells resistant to diphtheria-toxin-catalyzed ADP-ribosylation of EF-2 remain sensitive to cellular ADP-ribosylation of EF-2. Adenosine Diphosphate 79-82 elongation factor 2 Cricetulus griseus 0-4 1313365-10 1992 EF-2 mutants of pyBHK and CHO-K1 cells resistant to diphtheria-toxin-catalyzed ADP-ribosylation of EF-2 remain sensitive to cellular ADP-ribosylation of EF-2. Adenosine Diphosphate 79-82 elongation factor 2 Cricetulus griseus 99-103 1313365-10 1992 EF-2 mutants of pyBHK and CHO-K1 cells resistant to diphtheria-toxin-catalyzed ADP-ribosylation of EF-2 remain sensitive to cellular ADP-ribosylation of EF-2. Adenosine Diphosphate 79-82 elongation factor 2 Cricetulus griseus 99-103 1313365-10 1992 EF-2 mutants of pyBHK and CHO-K1 cells resistant to diphtheria-toxin-catalyzed ADP-ribosylation of EF-2 remain sensitive to cellular ADP-ribosylation of EF-2. Adenosine Diphosphate 133-136 elongation factor 2 Cricetulus griseus 0-4 1313365-11 1992 The 32P-labelled moiety of ADP-ribosylated EF-2 was digested by snake venom phosphodiesterase and the product was identified as AMP. Adenosine Diphosphate 27-30 elongation factor 2 Cricetulus griseus 43-47 1313365-13 1992 When purified EF-2 from pyBHK cells was incubated with [carbonyl-14C]nicotinamide and diphtheria toxin fragment A, under conditions for reversal of the ADP-ribosylation reaction, [14C]NAD was generated. Adenosine Diphosphate 152-155 elongation factor 2 Cricetulus griseus 14-18 1313365-14 1992 The results suggest that cellular ADP-ribosylated EF-2 exists in a variety of cell types, and the ribosylated product is identical to that produced by toxin ADP-ribosylation of EF-2, except in diphthamide mutant cells. Adenosine Diphosphate 34-37 elongation factor 2 Cricetulus griseus 50-54 1313365-14 1992 The results suggest that cellular ADP-ribosylated EF-2 exists in a variety of cell types, and the ribosylated product is identical to that produced by toxin ADP-ribosylation of EF-2, except in diphthamide mutant cells. Adenosine Diphosphate 34-37 elongation factor 2 Cricetulus griseus 177-181 1313365-15 1992 Studies with the mutant cell lines indicate that the toxin and the cellular transferase, however, recognize different determinants at the ADP-ribose acceptor site in EF-2. Adenosine Diphosphate 138-141 elongation factor 2 Cricetulus griseus 166-170 1476544-1 1992 2",3"-O-(2,4,6-trinitrophenyl)-8-azido (TNP-8N3)-AMP, -ADP, and -ATP bind tightly to the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum and become covalently attached on irradiation at alkaline pH, concomitant with inactivation of ATPase activity (Seebregts, C. J., and McIntosh, D. B. Adenosine Diphosphate 54-58 dynein axonemal heavy chain 8 Homo sapiens 96-102 1476544-1 1992 2",3"-O-(2,4,6-trinitrophenyl)-8-azido (TNP-8N3)-AMP, -ADP, and -ATP bind tightly to the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum and become covalently attached on irradiation at alkaline pH, concomitant with inactivation of ATPase activity (Seebregts, C. J., and McIntosh, D. B. Adenosine Diphosphate 54-58 dynein axonemal heavy chain 8 Homo sapiens 240-246 1347044-5 1992 The drug-induced ATPase requires magnesium ions, does not utilize ADP or AMP as substrates, exhibits a half-maximal activation at about 0.5 mM MgATP, and its maximal activity (about 3-5 mumol/mg MDR protein/min) approaches that of the well characterized ion transport ATPases. Adenosine Diphosphate 66-69 dynein axonemal heavy chain 8 Homo sapiens 17-23 1733958-12 1992 Kinetic studies of the ADP-ribosylation and peptide mapping of the reaction products of rhoB p21 by EDIN and C3 suggest that the mode of action of the ADP-ribosylation by EDIN is quite similar to that by C3 and that the ADP-ribosylation site of rhoB p21 by EDIN is presumably the same as that by C3. Adenosine Diphosphate 151-154 ras homolog family member B Homo sapiens 88-92 1733958-12 1992 Kinetic studies of the ADP-ribosylation and peptide mapping of the reaction products of rhoB p21 by EDIN and C3 suggest that the mode of action of the ADP-ribosylation by EDIN is quite similar to that by C3 and that the ADP-ribosylation site of rhoB p21 by EDIN is presumably the same as that by C3. Adenosine Diphosphate 151-154 ras homolog family member B Homo sapiens 245-249 24637024-8 2014 ADP dissociation from the actin ATM1 complex (acto-ATM1) was extremely slow, which accounts for the low actin-sliding velocity, low actin-activated ATPase activity, and high duty ratio. Adenosine Diphosphate 0-3 myosin 1 Arabidopsis thaliana 51-55 24637024-9 2014 The rate of ADP dissociation from acto-ATM1 was markedly biphasic with fast and slow phase rates (5.1 and 0.41 s(-1), respectively). Adenosine Diphosphate 12-15 myosin 1 Arabidopsis thaliana 39-43 24637024-10 2014 Physiological concentrations of free Mg(2+) modulated actin-sliding velocity and actin-activated ATPase activity by changing the rate of ADP dissociation from acto-ATM1. Adenosine Diphosphate 137-140 myosin 1 Arabidopsis thaliana 164-168 24970225-4 2014 Here we demonstrate dependence of GroEL reassembly efficiency on concentrations of the essential factors (Mg2+, ADP, ATP, GroES, ammonium sulfate, NaCl and glycerol). Adenosine Diphosphate 112-115 heat shock protein family D (Hsp60) member 1 Homo sapiens 34-39 23981082-5 2014 Loss-of-function polymorphisms in CYP2C19 are the strongest individual variables affecting pharmacokinetics and antiplatelet response to clopidogrel, but explain no more than 5 to 12% of the variability in adenosine diphosphate-induced platelet aggregation on clopidogrel. Adenosine Diphosphate 206-227 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 34-41 25374234-3 2014 HSP70 was purified from renal cell carcinoma specimens by serial column chromatography on Con A-sepharose, PD-10, ADP-agarose and DEAE-cellulose, and finally subjected to fast protein liquid chromatography (FPLC). Adenosine Diphosphate 114-117 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 106-109 integrin subunit alpha 2b Homo sapiens 79-84 24401225-5 2014 Platelet surface expression of P-selectin and activated glycoprotein IIb/IIIa (GPIIb/IIIa) in response to ADP, AA, and TRAP-6, and the formation of monocyte-platelet aggregates (MPA) in response to ADP and TRAP-6 were assessed by flow cytometry. Adenosine Diphosphate 198-201 integrin subunit alpha 2b Homo sapiens 79-84 24401225-7 2014 Likewise, the expression of P-selectin and GPIIb/IIIa following stimulation with ADP and AA, and MPA formation in response to ADP were significantly higher in PAD patients than in CAD patients. Adenosine Diphosphate 81-84 integrin subunit alpha 2b Homo sapiens 43-48 24756715-4 2014 TRPM2 is a Ca(2+)-permeable nonselective cation channel embedded in the plasma membrane and/or lysosomal compartments that is primarily activated in a synergistic fashion by intracellular ADP-ribose (ADPr) and Ca(2+). Adenosine Diphosphate 188-191 transient receptor potential cation channel subfamily M member 2 Homo sapiens 0-5 24940514-3 2014 Consistent with this, we have recently shown that IL-17A increases human and murine platelet response to ADP. Adenosine Diphosphate 105-108 interleukin 17A Homo sapiens 50-56 24022487-4 2013 Here we present evidence that, for the GroEL-GroES chaperonin system, the non-native substrate protein enters the folding cycle on the trans ring of the double-ring GroEL-ATP-GroES complex rather than the ADP-bound complex. Adenosine Diphosphate 205-208 heat shock protein family D (Hsp60) member 1 Homo sapiens 39-44 24073201-6 2013 The isolated mitochondria from both modified strains developed 85% of the membrane potential attained by mitochondria of control strains, and addition of ADP yielded bongkrekate-sensitive depolarizations implying acquired sensitivity of ArAAC-mediated adenine nucleotide exchange to this poison, independent from SAL1. Adenosine Diphosphate 154-157 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 313-317 23861496-0 2013 Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 A resolution. Adenosine Diphosphate 29-32 heat shock protein family D (Hsp60) member 1 Homo sapiens 23-28 23861496-8 2013 By imposing sevenfold symmetry on each of the subunits of the crystal structure of GroEL-ADP, we showed that the synthetic rings of (X-ray) GroEL-ADP and (cryo-EM) GroEL-ATP are structurally closely related. Adenosine Diphosphate 89-92 heat shock protein family D (Hsp60) member 1 Homo sapiens 83-88 23861496-8 2013 By imposing sevenfold symmetry on each of the subunits of the crystal structure of GroEL-ADP, we showed that the synthetic rings of (X-ray) GroEL-ADP and (cryo-EM) GroEL-ATP are structurally closely related. Adenosine Diphosphate 89-92 heat shock protein family D (Hsp60) member 1 Homo sapiens 140-145 23861496-8 2013 By imposing sevenfold symmetry on each of the subunits of the crystal structure of GroEL-ADP, we showed that the synthetic rings of (X-ray) GroEL-ADP and (cryo-EM) GroEL-ATP are structurally closely related. Adenosine Diphosphate 89-92 heat shock protein family D (Hsp60) member 1 Homo sapiens 140-145 23744064-3 2013 Here, we have scrutinized the behavior of the yeast mitochondrial ADP/ATP carrier AAC3 in blue native gels. Adenosine Diphosphate 66-69 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 82-86 23770670-5 2013 We report here that TCDD-induced TiPARP also targets PEPCK for ADP-ribosylation. Adenosine Diphosphate 63-66 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 53-58 23770670-6 2013 Both cytosolic and mitochondrial forms of PEPCK were found to undergo ADP-ribosylation. Adenosine Diphosphate 70-73 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 42-47 22197119-6 2013 RESULTS: MPAs and expression of platelet receptors CD41 and PAC-1 were significantly lower in patients with than patients without PIA, both with and without ADP stimulation. Adenosine Diphosphate 157-160 integrin subunit alpha 2b Homo sapiens 51-55 23575945-9 2013 Thus we propose that KATP opening in response to lowered glucose concentration requires AMPK activity, perhaps in concert with increased AK and UCP2 to enable mitochondrial-derived ADP signals to be transferred to plasma membrane KATP by phosphotransfer cascades. Adenosine Diphosphate 181-184 uncoupling protein 2 Rattus norvegicus 144-148 24159812-1 2013 The addition of Na and Ca chlorides to adenine (A), adenosine (Ado) and adenosine diphosphate solutions at pH 5.3 has been shown to result in intensification of EPR signals in samples irradiated by near UV at 77 K and appearance of signals of Cl2-* and peroxyl radicals. Adenosine Diphosphate 72-93 endogenous retrovirus group W member 5 Homo sapiens 243-246 1370696-5 1992 Structure-activity studies demonstrated that the minimum structural requirements for binding to the platelet PGI2 receptor and inhibition of ADP-induced platelet aggregation within this series are a vicinally diphenylated pyrazole substituted with an omega-alkanoic acid side chain eight or nine atoms long. Adenosine Diphosphate 141-144 prostaglandin I2 receptor Homo sapiens 109-122 1748655-10 1991 Upon saturation of the target protein, rS1 ADP-ribosylated equivalent moles of transducin or T alpha, with the linear velocity of rS1-mediated ADP-ribosylation of transducin approximately 16-fold more rapid than the rate of ADP-ribosylation of T alpha. Adenosine Diphosphate 43-46 retinoschisin 1 Rattus norvegicus 39-42 1748655-10 1991 Upon saturation of the target protein, rS1 ADP-ribosylated equivalent moles of transducin or T alpha, with the linear velocity of rS1-mediated ADP-ribosylation of transducin approximately 16-fold more rapid than the rate of ADP-ribosylation of T alpha. Adenosine Diphosphate 43-46 retinoschisin 1 Rattus norvegicus 130-133 1748655-10 1991 Upon saturation of the target protein, rS1 ADP-ribosylated equivalent moles of transducin or T alpha, with the linear velocity of rS1-mediated ADP-ribosylation of transducin approximately 16-fold more rapid than the rate of ADP-ribosylation of T alpha. Adenosine Diphosphate 143-146 retinoschisin 1 Rattus norvegicus 39-42 1748655-10 1991 Upon saturation of the target protein, rS1 ADP-ribosylated equivalent moles of transducin or T alpha, with the linear velocity of rS1-mediated ADP-ribosylation of transducin approximately 16-fold more rapid than the rate of ADP-ribosylation of T alpha. Adenosine Diphosphate 143-146 retinoschisin 1 Rattus norvegicus 130-133 1748655-12 1991 These data indicate that the amino-terminal 180 amino acids of S1 confer the specificity for ADP-ribosylation primarily through the interaction with T alpha, while residues between 195 and 219 of S1 confer high affinity binding to transducin primarily through the interaction, either directly or indirectly, with T beta gamma. Adenosine Diphosphate 93-96 retinoschisin 1 Rattus norvegicus 63-65 1803347-3 1991 The amounts of IAP-catalyzed ADP-ribosylation of Gi/Go in the presence of 100 microM guanosine 5"-O-(2-thiodiphosphate) (GDP beta S) and 50 mM EDTA and in the absence of MgCl2 were in proportion to the protein contents between 30 and 60 micrograms/tube, suggesting that the determination of [32P]ADP-ribosylation could be used quantitatively within this limited range. Adenosine Diphosphate 29-32 Cd47 molecule Rattus norvegicus 15-18 1803347-3 1991 The amounts of IAP-catalyzed ADP-ribosylation of Gi/Go in the presence of 100 microM guanosine 5"-O-(2-thiodiphosphate) (GDP beta S) and 50 mM EDTA and in the absence of MgCl2 were in proportion to the protein contents between 30 and 60 micrograms/tube, suggesting that the determination of [32P]ADP-ribosylation could be used quantitatively within this limited range. Adenosine Diphosphate 296-299 Cd47 molecule Rattus norvegicus 15-18 1936256-5 1991 The effects of IAP were well correlated with the degree of ADP-ribosylation of a membrane 40-kDa protein. Adenosine Diphosphate 59-62 islet amyloid polypeptide Homo sapiens 15-18 1717069-7 1991 When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not. Adenosine Diphosphate 40-61 ral guanine nucleotide dissociation stimulator Homo sapiens 125-129 1906886-6 1991 Further, morphological studies were performed on the RGDS-ADP-stimulated platelets. Adenosine Diphosphate 58-61 ral guanine nucleotide dissociation stimulator Homo sapiens 53-57 2057914-6 1991 Quantitative analysis demonstrated that, TRK-100 significantly reduced the ADP aggregation (1 microM) from 55.2 +/- 21.3% to 24.0 +/- 14.7% (+/- SD; p less than 0.05) and the platelet accumulation index (25.7 +/- 17.2% vs 10.4 +/- 10.4%; p less than 0.05). Adenosine Diphosphate 75-78 neurotrophic receptor tyrosine kinase 1 Homo sapiens 41-44 1993675-10 1991 These studies indicate that (i) rS1, purified from Escherichia coli, possesses biochemical properties similar to S1 subunit purified from pertussis toxin, (ii) amino acids 1-180 of the S1 subunit contain residues required for NAD binding, N-glycosidic cleavage, and transfer of ADP-ribose to transducin, and (iii) residues between 181 and 219 of the S1 subunit are required for efficient ADP-ribosyltransferase activity. Adenosine Diphosphate 278-281 retinoschisin 1 Rattus norvegicus 32-35 1993675-10 1991 These studies indicate that (i) rS1, purified from Escherichia coli, possesses biochemical properties similar to S1 subunit purified from pertussis toxin, (ii) amino acids 1-180 of the S1 subunit contain residues required for NAD binding, N-glycosidic cleavage, and transfer of ADP-ribose to transducin, and (iii) residues between 181 and 219 of the S1 subunit are required for efficient ADP-ribosyltransferase activity. Adenosine Diphosphate 278-281 retinoschisin 1 Rattus norvegicus 33-35 1906007-1 1991 Studies were made on the effects of Li+ on ADP ribosylation of inhibitory GTP-binding (Gi) protein by islet-activating protein (IAP), pertussis toxin. Adenosine Diphosphate 43-46 Cd47 molecule Rattus norvegicus 102-126 1906007-1 1991 Studies were made on the effects of Li+ on ADP ribosylation of inhibitory GTP-binding (Gi) protein by islet-activating protein (IAP), pertussis toxin. Adenosine Diphosphate 43-46 Cd47 molecule Rattus norvegicus 128-131 1906007-7 1991 Moreover, LiCl decreased the ADP ribosylation of purified Gi protein by IAP. Adenosine Diphosphate 29-32 Cd47 molecule Rattus norvegicus 72-75 1670772-6 1991 ATP hydrolysis to ADP and Pi is essential for A1-dependent pol delta activity, and we have shown that A1 contains an intrinsic ATPase which is stimulated by DNA. Adenosine Diphosphate 18-21 dynein axonemal heavy chain 8 Homo sapiens 127-133 2125009-4 1990 These alkylations resulted in loss of its ability to be ADP-ribosylated by IAP and to associate with beta gamma, but leaving the GTP-binding site of alpha o intact. Adenosine Diphosphate 56-59 Cd47 molecule Rattus norvegicus 75-78 2148055-3 1990 We found that the rate of plasmin-induced aggregation of washed intact platelets and that of platelets modified by 5"-p-fluorosulfonylbenzoyladenosine (FSBA, an affinity analogue of ADP, which covalently modifies aggregin) were similar, indicating that the aggregation is independent of the ADP effect. Adenosine Diphosphate 182-185 plasminogen Homo sapiens 26-33 2148055-3 1990 We found that the rate of plasmin-induced aggregation of washed intact platelets and that of platelets modified by 5"-p-fluorosulfonylbenzoyladenosine (FSBA, an affinity analogue of ADP, which covalently modifies aggregin) were similar, indicating that the aggregation is independent of the ADP effect. Adenosine Diphosphate 291-294 plasminogen Homo sapiens 26-33 2148684-3 1990 The ATPase hydrolyzes ATP to ADP in a reaction that is completely dependent on the presence of DNA. Adenosine Diphosphate 29-32 dynein axonemal heavy chain 8 Homo sapiens 4-10 2361132-9 1990 Assuming that S1.MgADP.Vi is an analogue for S1.MgADP.Pi, the structural changes observed for S1-ligand complexes in solution are discussed in relation to possible structural changes of intermediates on the kinetic pathway of ATPase hydrolysis. Adenosine Diphosphate 17-22 dynein axonemal heavy chain 8 Homo sapiens 226-232 2361132-9 1990 Assuming that S1.MgADP.Vi is an analogue for S1.MgADP.Pi, the structural changes observed for S1-ligand complexes in solution are discussed in relation to possible structural changes of intermediates on the kinetic pathway of ATPase hydrolysis. Adenosine Diphosphate 48-53 dynein axonemal heavy chain 8 Homo sapiens 226-232 2137348-3 1990 Sulfite activates the ATPase, and many molecules of ATP per synthase can be hydrolyzed before most of the bound [3H]ADP is released, a result interpreted as indicating that the ADP is not bound at a site participating in catalysis by the sulfite-activated enzyme [Larson, E. M., Umbach, A., & Jagendorf, A. T. (1989) Biochim. Adenosine Diphosphate 116-119 dynein axonemal heavy chain 8 Homo sapiens 22-28 2137348-3 1990 Sulfite activates the ATPase, and many molecules of ATP per synthase can be hydrolyzed before most of the bound [3H]ADP is released, a result interpreted as indicating that the ADP is not bound at a site participating in catalysis by the sulfite-activated enzyme [Larson, E. M., Umbach, A., & Jagendorf, A. T. (1989) Biochim. Adenosine Diphosphate 177-180 dynein axonemal heavy chain 8 Homo sapiens 22-28 2137348-7 1990 The Mg2(+)- and ADP-inhibited enzyme when exposed to MgATP and 20-100 mM sulfite shows a lag of about 1 min at 22 degrees C and of about 15 s at 37 degrees C before reaching the same steady-state rate as attained with light-activated ATPase that has not been inhibited by Mg2+ and ADP. Adenosine Diphosphate 16-19 dynein axonemal heavy chain 8 Homo sapiens 234-240 2109061-17 1990 However, with PAF and ADP, the subsequent recovery in pHi was slow and did not rise above basal levels. Adenosine Diphosphate 22-25 glucose-6-phosphate isomerase Homo sapiens 54-57 23380744-7 2013 Targ-CD39 was more effective at preventing ADP-induced platelet activation than non-targ-CD39. Adenosine Diphosphate 43-46 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 5-9 34948316-4 2021 Adenosine is produced starting from the highly immunostimulatory ATP, which is progressively hydrolyzed to ADP and adenosine by CD39 and CD73. Adenosine Diphosphate 107-110 5'-nucleotidase ecto Homo sapiens 137-141 34581777-3 2022 Here, we report GWAS of pathway specific functional responses to agonism by ADP, a glycoprotein VI-specific collagen mimetic and thrombin receptor-agonist peptides, each specific to one of the G protein-coupled receptors PAR-1 and PAR-4, in subsets of 1,562 individuals. Adenosine Diphosphate 76-79 Prader Willi/Angelman region RNA 4 Homo sapiens 231-236 34076906-11 2021 Taken together, the results suggested that P2X7 receptors can be sensitized to ATP by NAD+ /ARTC2-catalyzed ADP-ribosylation, which allows astrocytes to drive P2X7 receptor-mediated ischemic tolerance even though PC only slightly increases the amount of eATP. Adenosine Diphosphate 108-111 ADP-ribosyltransferase 2a Mus musculus 92-97 23470885-7 2013 ADP-specific assays (ADP-LTA, the VASP index and VerifyNow-P2Y12) differed according to CYP2C19 genotype, with a significant gene-dose effect (PMs>IMs>EMs). Adenosine Diphosphate 0-3 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 88-95 34571872-6 2021 Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 dephosphorylates ATP to ADP and to AMP, which in turn, is hydrolysed to adenosine by ecto-5"-nucleotidase (CD73). Adenosine Diphosphate 89-92 5'-nucleotidase ecto Homo sapiens 150-170 23470885-10 2013 CONCLUSIONS: CYP2C19 loss-of-function genotype is associated with more frequent high platelet reactivity, as assessed by ADP-specific platelet function tests, in Japanese patients. Adenosine Diphosphate 122-125 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 14-21 34571872-6 2021 Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 dephosphorylates ATP to ADP and to AMP, which in turn, is hydrolysed to adenosine by ecto-5"-nucleotidase (CD73). Adenosine Diphosphate 89-92 5'-nucleotidase ecto Homo sapiens 172-176 23558828-7 2013 At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71+-11.0% and +37+-7.5%, respectively), than in CAD patients (+37+-8.6% and +19+-4.5%, respectively) and controls (+29+-3.5% and +21+-3.1%, respectively; P<0.001 for both). Adenosine Diphosphate 63-66 integrin subunit alpha 2b Homo sapiens 18-22 22372532-9 2013 We demonstrated that diminished expression of active GPIIb/IIIa in the ADP-activated platelets is associated with increased carotid IMT, independently of stroke. Adenosine Diphosphate 71-74 integrin subunit alpha 2b Homo sapiens 53-58 23516601-6 2013 We demonstrate for the first time, for any ART derivative, that ADP NPs can down regulate the oncogenic protein HER2, and its counterpart, HER3 in a HER2+ cell line. Adenosine Diphosphate 64-67 erb-b2 receptor tyrosine kinase 3 Mus musculus 139-143 25509129-5 2013 Incubation of oocytes in the medium with the subsequent addition of ADP and GDP have an inhibitory effect on the release of Ca2+ from intracellular stores, stimulated joint action of growth hormone and theophylline. Adenosine Diphosphate 68-71 carbonic anhydrase 2 Homo sapiens 124-127 22908276-0 2012 Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling. Adenosine Diphosphate 22-25 ADP ribosylation factor guanine nucleotide exchange factor 2 Homo sapiens 56-60 22908276-0 2012 Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling. Adenosine Diphosphate 22-25 integrin subunit beta 1 Homo sapiens 90-104 22637533-0 2012 Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. Adenosine Diphosphate 26-29 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 118-126 22637533-0 2012 Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. Adenosine Diphosphate 26-29 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 127-131 22637533-8 2012 In summary, we have identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides. Adenosine Diphosphate 178-181 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 78-86 22637533-8 2012 In summary, we have identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides. Adenosine Diphosphate 178-181 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 87-91 22730437-6 2012 We show that isolated cow lung COX containing COX4i2 is about twice as active (88 and 102% increased activity in the presence of allosteric activator ADP and inhibitor ATP, respectively) as liver COX, which lacks COX4i2. Adenosine Diphosphate 150-153 cytochrome c oxidase subunit 7A1 Bos taurus 31-34 22730437-6 2012 We show that isolated cow lung COX containing COX4i2 is about twice as active (88 and 102% increased activity in the presence of allosteric activator ADP and inhibitor ATP, respectively) as liver COX, which lacks COX4i2. Adenosine Diphosphate 150-153 cytochrome c oxidase subunit 7A1 Bos taurus 46-49 22622462-1 2012 Ectonucleoside triphosphate diphosphohydrolase-1 hydrolyzes extracellular ATP and ADP to AMP. Adenosine Diphosphate 82-85 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-48 22459907-6 2012 RESULTS: Increasing quartiles of 20 muM ADP induced platelet aggregation after clopidogrel loading were associated with increasing levels of TRAP mediated platelet aggregation. Adenosine Diphosphate 40-43 TRAP Homo sapiens 141-145 22459907-7 2012 Patients in the highest quartile (clopidogrel non-responders) of post treatment ADP aggregation had significantly higher TRAP mediated aggregation than the patients in the lowest quartile (clopidogrel responders) [TRAP 15 muM: 79.6 +- 5% vs. 69.5 +- 8%, p<0.001]. Adenosine Diphosphate 80-83 TRAP Homo sapiens 121-125 22459907-7 2012 Patients in the highest quartile (clopidogrel non-responders) of post treatment ADP aggregation had significantly higher TRAP mediated aggregation than the patients in the lowest quartile (clopidogrel responders) [TRAP 15 muM: 79.6 +- 5% vs. 69.5 +- 8%, p<0.001]. Adenosine Diphosphate 80-83 TRAP Homo sapiens 214-218 22657152-10 2012 Steady-state measurements in the absence of citrate and CoA showed that MgADP was produced by both wild type and H760A forms of ACL, with rates at three magnitudes lower than that of k(cat) for the full biosynthetic reaction. Adenosine Diphosphate 72-77 ATP citrate lyase Homo sapiens 128-131 22007612-6 2012 However, carriage of 2 CYP2C19 loss-of-function alleles is still associated with the risk of high platelet reactivity (defined by by 5 microM ADP-induced maximal platelet aggregation >46%), which clinical impact needs to be validated in future clinical trials. Adenosine Diphosphate 142-145 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 23-30 22068704-4 2012 In the new assay, the UNAM product of the MurB reaction is ligated to L-alanine by the next enzyme in the peptidoglycan biosynthesis pathway, MurC, resulting in hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP). Adenosine Diphosphate 207-228 caveolae associated protein 4 Homo sapiens 142-146 22068704-4 2012 In the new assay, the UNAM product of the MurB reaction is ligated to L-alanine by the next enzyme in the peptidoglycan biosynthesis pathway, MurC, resulting in hydrolysis of adenosine triphosphate (ATP) to adenosine diphosphate (ADP). Adenosine Diphosphate 230-233 caveolae associated protein 4 Homo sapiens 142-146 22476468-4 2012 Previously, we showed that overexpression of Arabidopsis purple acid phosphatase 10 (AtPAP10) improved the growth of plants on Pi-deficient medium (P- medium) supplemented with the organophosphate compound ADP; in contrast, the growth of atpap10 mutant lines was reduced on the same medium. Adenosine Diphosphate 206-209 purple acid phosphatase 10 Arabidopsis thaliana 57-83 22476468-4 2012 Previously, we showed that overexpression of Arabidopsis purple acid phosphatase 10 (AtPAP10) improved the growth of plants on Pi-deficient medium (P- medium) supplemented with the organophosphate compound ADP; in contrast, the growth of atpap10 mutant lines was reduced on the same medium. Adenosine Diphosphate 206-209 purple acid phosphatase 10 Arabidopsis thaliana 85-92 22476468-6 2012 The results showed that AtPAP10 could utilize rhizosphere organophosphates other than ADP for plant growth but with different utilization efficiencies. Adenosine Diphosphate 86-89 purple acid phosphatase 10 Arabidopsis thaliana 24-31 22390861-2 2012 CYP2C19*2 is associated with HPR by ADP. Adenosine Diphosphate 36-39 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 22390861-5 2012 At the landmark analysis in the first 6 months, HPR by ADP and CYP2C19*2 allele were both significantly and independently associated with MACE [HPR by ADP: HR = 2.0 (95% CI 1.2-3.4), p = 0.01; CYP2C19*2 allele: HR = 2.3 (95% CI 1.3-3.9), p = 0.003]. Adenosine Diphosphate 55-58 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 193-200 22390861-5 2012 At the landmark analysis in the first 6 months, HPR by ADP and CYP2C19*2 allele were both significantly and independently associated with MACE [HPR by ADP: HR = 2.0 (95% CI 1.2-3.4), p = 0.01; CYP2C19*2 allele: HR = 2.3 (95% CI 1.3-3.9), p = 0.003]. Adenosine Diphosphate 151-154 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 63-70 22390861-5 2012 At the landmark analysis in the first 6 months, HPR by ADP and CYP2C19*2 allele were both significantly and independently associated with MACE [HPR by ADP: HR = 2.0 (95% CI 1.2-3.4), p = 0.01; CYP2C19*2 allele: HR = 2.3 (95% CI 1.3-3.9), p = 0.003]. Adenosine Diphosphate 151-154 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 193-200 22715356-12 2012 BDNF mRNA expression in OASF was induced both by P2X receptor agonists ATP and ADP, but not by UTP, an agonist of P2Y purinergic receptors. Adenosine Diphosphate 79-82 brain derived neurotrophic factor Homo sapiens 0-4 21939667-2 2011 Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which converts the proinflammatory molecules ATP or ADP to AMP is a key regulator of purinergic modulation. Adenosine Diphosphate 117-120 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-48 21939667-2 2011 Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which converts the proinflammatory molecules ATP or ADP to AMP is a key regulator of purinergic modulation. Adenosine Diphosphate 117-120 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 50-57 21939667-2 2011 Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which converts the proinflammatory molecules ATP or ADP to AMP is a key regulator of purinergic modulation. Adenosine Diphosphate 117-120 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 59-63 34575427-8 2021 Docking investigation revealed that the drug binds to the ADP/ATP sites on KIR6.1/2 and SUR2A/B and on the sulfonylureas site showing low binding energy <6 Kcal/mol for the KIR6.1/2-SUR2 subunits vs. the <4 Kcal/mol for the KIR6.2-SUR1. Adenosine Diphosphate 58-61 ATP binding cassette subfamily C member 9 Homo sapiens 182-186 21872611-11 2011 Enhanced extracellular adenosine levels in ENT1-null cardiomyocytes appeared to come from a pool of extracellular nucleotides including IMP, AMP and ADP. Adenosine Diphosphate 149-152 solute carrier family 29 (nucleoside transporters), member 1 Mus musculus 43-47 34320205-4 2021 To decrease the accumulation of acetic acid, the major ADP/ATP carrier of the mitochondrial inner membrane, AAC2, was upregulated and determined to accelerate ethanol utilization and itaconic acid production. Adenosine Diphosphate 55-58 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 108-112 21697503-3 2011 Hsc70 binding to CFTR was destabilized by the C-terminal domain of Bag-1 (CBag), which stimulates client release by accelerating ADP-ATP exchange. Adenosine Diphosphate 129-132 heat shock protein family A (Hsp70) member 8 Homo sapiens 0-5 34489954-1 2021 On murine T cells, mono-ADP ribosyltransferase ARTC2.2 catalyzes ADP-ribosylation of various surface proteins when nicotinamide adenine dinucleotide (NAD+) is released into the extracellular compartment. Adenosine Diphosphate 65-68 ADP-ribosyltransferase 2a Mus musculus 47-52 21063895-5 2011 Both inhibitors inhibited ADP-stimulated respirations concurrently with Src activation and complex IV activation by ATP, while having no effect or increasing the activity of the other complexes. Adenosine Diphosphate 26-29 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 72-75 34143384-0 2021 Clinical validation of AggreGuide A-100 ADP, a novel assay for assessing the antiplatelet effect of oral P2Y12 antagonists. Adenosine Diphosphate 40-43 purinergic receptor P2Y12 Homo sapiens 105-110 35514261-1 2022 Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively. Adenosine Diphosphate 46-49 purinergic receptor P2Y12 Homo sapiens 113-118 21608060-0 2011 Biochemical and structural studies on the high affinity of Hsp70 for ADP. Adenosine Diphosphate 69-72 heat shock protein family A (Hsp70) member 4 Homo sapiens 59-64 35514261-10 2022 These data suggest that ADP-induced Rap1b activation requires both P2Y1 and P2Y12. Adenosine Diphosphate 24-27 RAP1B, member of RAS oncogene family Homo sapiens 36-41 35514261-10 2022 These data suggest that ADP-induced Rap1b activation requires both P2Y1 and P2Y12. Adenosine Diphosphate 24-27 purinergic receptor P2Y12 Homo sapiens 76-81 21608060-2 2011 ADP dissociation from Hsp70 is reportedly slow in the presence of inorganic phosphate (P(i) ). Adenosine Diphosphate 0-3 heat shock protein family A (Hsp70) member 4 Homo sapiens 22-27 35353230-7 2022 Complementary in vitro studies allowed for investigation of ADP-dependent effects on LSK cells. Adenosine Diphosphate 60-63 lymphocyte protein tyrosine kinase Mus musculus 85-88 21608060-3 2011 In this study, we investigated the interaction of Hsp70 and its nucleotide-binding domain (NBD) with ADP in detail, by isothermal titration calorimetry measurements and found that Mg(2+) ion dramatically elevates the affinity of Hsp70 for ADP. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 4 Homo sapiens 50-55 35353230-9 2022 We were able to detect P2Y12 in LSK, implicating a direct effect of ADP on LSK via P2Y12 signaling. Adenosine Diphosphate 68-71 lymphocyte protein tyrosine kinase Mus musculus 75-78 21608060-3 2011 In this study, we investigated the interaction of Hsp70 and its nucleotide-binding domain (NBD) with ADP in detail, by isothermal titration calorimetry measurements and found that Mg(2+) ion dramatically elevates the affinity of Hsp70 for ADP. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 4 Homo sapiens 230-235 21608060-3 2011 In this study, we investigated the interaction of Hsp70 and its nucleotide-binding domain (NBD) with ADP in detail, by isothermal titration calorimetry measurements and found that Mg(2+) ion dramatically elevates the affinity of Hsp70 for ADP. Adenosine Diphosphate 240-243 heat shock protein family A (Hsp70) member 4 Homo sapiens 50-55 35269975-6 2022 Deletion of Pcyox1 reduced the platelet/leukocyte aggregates in whole blood, as well as the platelet aggregation, the alpha granules release, and the alphaIIbbeta3 integrin activation in platelet-rich plasma, in response to adenosine diphosphate (ADP) or thrombin receptor agonist peptide (TRAP). Adenosine Diphosphate 247-250 prenylcysteine oxidase 1 Mus musculus 12-18 21709234-9 2011 These findings establish an unsuspected role for ADP-ribose and ROS-mediated cation flux for innate immunity, opening up unique possibilities for immunomodulatory intervention through TRPM2. Adenosine Diphosphate 49-52 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 184-189 35169801-2 2022 Here, we determined neutron and X-ray crystal structures of the SARS-CoV-2 NSP3 macrodomain using multiple crystal forms, temperatures, and pHs, across the apo and ADP-ribose-bound states. Adenosine Diphosphate 164-167 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 75-79 21592965-4 2011 Two structures are wild-type BC in complex with two ADP molecules and two Ca(2+) ions or two ADP molecules and one Mg(2+) ion. Adenosine Diphosphate 52-55 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 29-31 35441048-4 2022 Given the recently revealed deviations in the correlation between the protonophoric activity of some uncouplers and their ability to stimulate mitochondrial respiration, this review addresses the involvement of some proteins of the inner mitochondrial membrane, such as the ATP/ADP antiporter, dicarboxylate carrier, and ATPase, in the uncoupling process. Adenosine Diphosphate 278-281 dynein axonemal heavy chain 8 Homo sapiens 321-327 2512294-6 1989 When membrane Gi-alpha [32P]ADP-ribosylated by CT plus fMLP or IAP was digested with trypsin, the radiolabeled fragments arising from the two proteins were different from each other. Adenosine Diphosphate 28-31 islet amyloid polypeptide Homo sapiens 63-66 21592965-4 2011 Two structures are wild-type BC in complex with two ADP molecules and two Ca(2+) ions or two ADP molecules and one Mg(2+) ion. Adenosine Diphosphate 93-96 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 29-31 21512161-8 2011 We show that hypothermia results in reduced ADP hydrolysis via reduction of CD39 (E-NTPDase1) activity, resulting in increased levels of ADP and subsequent augmented primary and secondary platelet activation. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 76-80 2613885-1 1989 The transition of smooth muscle myosin to the folded 10S monomeric conformation dramatically inhibits the release of the ATP hydrolysis products, ADP and Pi. Adenosine Diphosphate 146-149 myosin, heavy chain 15 Gallus gallus 32-38 2479640-6 1989 bFGF caused a small reduction in steady state NAD-dependent ADP-ribosylation and had no detectable effects on the steady-state levels of the Gi alpha (alpha subunit of the inhibitory G protein) 1, 2, and 3, visualized with specific antibodies in these cells. Adenosine Diphosphate 60-63 fibroblast growth factor 2 Rattus norvegicus 0-4 21512161-8 2011 We show that hypothermia results in reduced ADP hydrolysis via reduction of CD39 (E-NTPDase1) activity, resulting in increased levels of ADP and subsequent augmented primary and secondary platelet activation. Adenosine Diphosphate 137-140 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 76-80 21498885-9 2011 ARH1 also hydrolyzed OAADPr more rapidly at alkaline pH, but cleavage of ADP-ribose-arginine was faster at neutral pH than pH 9.0. Adenosine Diphosphate 23-26 ADP-ribosylarginine hydrolase Homo sapiens 0-4 21273003-10 2011 It is concluded that the alterations observed in the activities of NTPDase, 5"-nucleotidase and ADA in platelets of T. evansi-infected animals might be related to thrombocytopenia, that by reducing the number of platelets, there was less release of ATP and ADP. Adenosine Diphosphate 257-260 adenosine deaminase Rattus norvegicus 96-99 21315083-1 2011 We used FRET to examine the kinetics and thermodynamics of structural changes associated with ADP release in myosin V, which is thought to be a strain-sensitive step in many muscle and non-muscle myosins. Adenosine Diphosphate 94-97 myosin VA Homo sapiens 109-117 21258134-4 2011 Remarkably, MgAMP and MgADP but not MgATP protected PFK-1 against inhibition by palmitoyl-CoA indicating that acyl-CoAs regulate PFK-1 activity in concert with cellular high energy phosphate status. Adenosine Diphosphate 22-27 ATP-dependent 6-phosphofructokinase, platelet type Oryctolagus cuniculus 52-57 21258134-4 2011 Remarkably, MgAMP and MgADP but not MgATP protected PFK-1 against inhibition by palmitoyl-CoA indicating that acyl-CoAs regulate PFK-1 activity in concert with cellular high energy phosphate status. Adenosine Diphosphate 22-27 ATP-dependent 6-phosphofructokinase, platelet type Oryctolagus cuniculus 129-134 21121894-5 2011 The Hsp70 proteins are composed of two main domains: one that binds ATP and hydrolyses it to ADP and another which directly interacts with substrates. Adenosine Diphosphate 93-96 heat shock protein family A (Hsp70) member 4 Homo sapiens 4-9 21121894-7 2011 The general mechanism of the Hsp70s cycle is under the control of ATP hydrolysis that modulates the low (ATP-bound state) and high (ADP-bound state) affinity states of Hsp70 for substrates. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 4 Homo sapiens 29-34 21121894-7 2011 The general mechanism of the Hsp70s cycle is under the control of ATP hydrolysis that modulates the low (ATP-bound state) and high (ADP-bound state) affinity states of Hsp70 for substrates. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 4 Homo sapiens 168-173 21898229-2 2011 Nucleotide exchange factors (NEFs) accelerate ADP release from Hsp70 which results in rebinding of ATP and release of the substrate. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 63-68 21329420-8 2011 Positive correlation of the level of ADP-induced aggregation and GP IIb-IIIa content was detected in patients with ACS within the first hour upon admission to the hospital when they had already received aspirin, but not clopidogrel. Adenosine Diphosphate 37-40 integrin subunit alpha 2b Homo sapiens 65-71 21063242-2 2010 Pericellular adenosine is generated by the hydrolysis of extracellular adenosine triphosphate and adenosine diphosphate by the ectonucleotidase CD39 and the subsequent hydrolysis of adenosine monophosphate (AMP) by the ectonucleotidase CD73. Adenosine Diphosphate 98-119 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 144-148 20628048-9 2010 Inhibition of both human GDHs by estrogens was inversely related to their state of activation induced by ADP, with the slope of this correlation being steeper for hGDH2 than for hGDH1. Adenosine Diphosphate 105-108 glutamate dehydrogenase 2 Homo sapiens 163-168 20702811-9 2010 CONCLUSIONS: RvE1"s regulatory actions (ie, reducing ADP-stimulated P-selectin mobilization and actin polymerization) are human (h)ChemR23-dependent. Adenosine Diphosphate 53-56 chemerin chemokine-like receptor 1 Homo sapiens 131-138 20650899-2 2010 TRPM2 channels are co-activated by intracellular Ca(2+) and ADP-ribose (ADPR) but also modulated in intact cells by several additional factors. Adenosine Diphosphate 60-63 transient receptor potential cation channel subfamily M member 2 Homo sapiens 0-5 20650435-9 2010 Carriers of CYP2C19 variant (*2 or *3) (n = 80) had significantly higher 5 and 20 micromol/l ADP-induced PR(max) than did noncarriers (n = 46) (40.7 +/- 16.8% vs. 30.3 +/- 12.6%, p < 0.001; 54.2 +/- 16.2% vs. 40.5 +/- 15.8%, p < 0.001, respectively). Adenosine Diphosphate 93-96 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 12-19 20029400-6 2010 Furthermore, we have found that TRPM2 inhibited nuclear ADP-ribosylation in prostate cancer cells. Adenosine Diphosphate 56-59 transient receptor potential cation channel subfamily M member 2 Homo sapiens 32-37 20141534-0 2010 Adenine nucleotide transport via Sal1 carrier compensates for the essential function of the mitochondrial ADP/ATP carrier. Adenosine Diphosphate 106-109 spalt like transcription factor 1 Homo sapiens 33-37 20141534-3 2010 However, the mechanism by which Sal1p rescues the growth of Deltaaac2 mutants is not clear and it was proposed that both Sal1p and Aac2p share a common vital function other than ADP/ATP exchange. Adenosine Diphosphate 178-181 solute carrier family 25 member 5 Homo sapiens 131-136 20076852-6 2010 In the stroke patients the increased expressions of P-selectin and active GP IIb/IIIa in TRAP- or ADP-activated cells were less pronounced (p<0.01), while the increments in PMP fraction remained higher (p<0.05). Adenosine Diphosphate 98-101 integrin subunit alpha 2b Homo sapiens 74-80 2808404-5 1989 In spite of the inhibition of 5"-nucleotidase by ADP, adenosine was produced very rapidly by smooth muscle cells. Adenosine Diphosphate 49-52 5'-nucleotidase ecto Homo sapiens 30-45 20067476-8 2010 In vitro, the concentration-response curves of relaxation to ADP and ATP were shifted to the left, revealing a facilitation of endothelial P2Y1 and P2Y2 receptor activation in Entpd1(-/-) mice. Adenosine Diphosphate 61-64 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 176-182 2516746-6 1989 The ADP-scavenger CP/CPK inhibits platelet aggregation and spreading by 25-30%. Adenosine Diphosphate 4-7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 21-24 20067476-9 2010 EC(50) values in Entpd1(+/+) versus Entpd1(-/-) aortic rings were 14 microM versus 0.35 microM for ADP, and 29 microM versus 1 microM for ATP. Adenosine Diphosphate 99-102 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 17-23 20024507-3 2010 Endothelial CD39/NTPDase1 and recombinant solCD39 rapidly metabolise nucleotides, including stimulatory ADP released from activated platelets, thereby suppressing additional platelet reactivity. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-16 2529923-7 1989 Measurement of secreted platelet-vWF and beta-thromboglobulin indicated that the increase seen with ADP was largely independent of alpha-granule secretion. Adenosine Diphosphate 100-103 pro-platelet basic protein Homo sapiens 41-61 20024507-3 2010 Endothelial CD39/NTPDase1 and recombinant solCD39 rapidly metabolise nucleotides, including stimulatory ADP released from activated platelets, thereby suppressing additional platelet reactivity. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 17-25 2801699-5 1989 Regulation of the enzyme alpha ketoglutarate dehydrogenase (alpha KGDH) was assessed by evaluating enzyme activity at varied levels of medium pH, Ca++, and adenosine diphosphate (ADP). Adenosine Diphosphate 156-177 oxoglutarate dehydrogenase Rattus norvegicus 25-58 19896942-0 2010 Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5"-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). Adenosine Diphosphate 171-174 histidine triad nucleotide-binding 4 Arabidopsis thaliana 51-56 2801699-5 1989 Regulation of the enzyme alpha ketoglutarate dehydrogenase (alpha KGDH) was assessed by evaluating enzyme activity at varied levels of medium pH, Ca++, and adenosine diphosphate (ADP). Adenosine Diphosphate 179-182 oxoglutarate dehydrogenase Rattus norvegicus 25-58 2814935-6 1989 The ADP-scavenger system (CP/CPK) inhibited platelet aggregation and spreading by 25-30%. Adenosine Diphosphate 4-7 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 29-32 19538153-7 2009 ADP/ATP exchange triggers Hsp70 dissociation from the ensuing enlarged unfolded peptide loop, which is then allowed to spontaneously refold into a closer-to-native conformation devoid of affinity for the chaperone. Adenosine Diphosphate 0-3 heat shock protein family A (Hsp70) member 4 Homo sapiens 26-31 19632996-4 2009 However, this disruption occurs only if RAD51 is present in an inactive ADP-bound form. Adenosine Diphosphate 72-75 RAD51 recombinase Homo sapiens 40-45 2549975-1 1989 Changes in 5"-nucleotidase activity were calculated on the basis of alterations in ATP, ADP, phosphocreatine, Pi, Mg2+, IMP and AMP, determined by using 31P n.m.r. Adenosine Diphosphate 88-91 5' nucleotidase, ecto Rattus norvegicus 11-26 2537764-0 1989 The ADP/ATP carrier from yeast (AAC-2) is uniquely suited for the assignment of the binding center by photoaffinity labeling. Adenosine Diphosphate 4-7 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 32-37 19520865-0 2009 Probing open conformation of GroEL rings by cross-linking reveals single and double open ring structures of GroEL in ADP and ATP. Adenosine Diphosphate 117-120 heat shock protein family D (Hsp60) member 1 Homo sapiens 29-34 19520865-0 2009 Probing open conformation of GroEL rings by cross-linking reveals single and double open ring structures of GroEL in ADP and ATP. Adenosine Diphosphate 117-120 heat shock protein family D (Hsp60) member 1 Homo sapiens 108-113 2971665-3 1988 At optimal concentrations, it increased these activities by up to 5-fold at pH 7.0 and 6 degrees C. Analysis of partial reactions of ATP hydrolysis by the purified ATPase revealed that TCS accelerated Ca2+ release from the ADP-sensitive phosphoenzyme up to 6-fold, whereas it affected other reaction steps to a much less extent, indicating that the site of the stimulatory action of TCS is rather specific in terms of the reaction sequence. Adenosine Diphosphate 223-226 dynein axonemal heavy chain 8 Homo sapiens 164-170 19520865-3 2009 The open ring-specific inter-subunit cross-linking between these Cys indicated that the number of rings in open conformation in GroEL was two in ATP (GroEL(OO)), one in ADP (GroEL(O)), and none in the absence of nucleotide. Adenosine Diphosphate 169-172 heat shock protein family D (Hsp60) member 1 Homo sapiens 128-133 2854181-6 1988 These assumptions also permit one to explain the experimental observation that external Na+ (with both high and low affinities) competes with K+, inhibiting the K+ influx due to the Na+-pump, and the kinetically similar behavior of Na+-ATPase and ATP/ADP exchange reactions at low variable Na+ concentrations. Adenosine Diphosphate 251-254 ATPase phospholipid transporting 8A2 Homo sapiens 236-239 19520865-3 2009 The open ring-specific inter-subunit cross-linking between these Cys indicated that the number of rings in open conformation in GroEL was two in ATP (GroEL(OO)), one in ADP (GroEL(O)), and none in the absence of nucleotide. Adenosine Diphosphate 169-172 heat shock protein family D (Hsp60) member 1 Homo sapiens 150-155 19520865-3 2009 The open ring-specific inter-subunit cross-linking between these Cys indicated that the number of rings in open conformation in GroEL was two in ATP (GroEL(OO)), one in ADP (GroEL(O)), and none in the absence of nucleotide. Adenosine Diphosphate 169-172 heat shock protein family D (Hsp60) member 1 Homo sapiens 150-155 19520865-4 2009 ADP showed an inhibitory effect on ATP-induced generation of GroEL(OO). Adenosine Diphosphate 0-3 heat shock protein family D (Hsp60) member 1 Homo sapiens 61-66 19106248-4 2009 Recombinant ALCAT1 was potently inhibited by ADP and ATP, but not by adenosine nucleotide analogs or other nucleotides, such as UTP and GTP, suggesting that ALCAT1 does not require ATP hydrolysis for its enzyme activity. Adenosine Diphosphate 45-48 lysocardiolipin acyltransferase 1 Mus musculus 12-18 2851591-6 1988 (4) A specific interaction site for ATP at the cytosolic domain of the enzyme is concluded from the increase of Km for cytochrome c after photolabelling of proteoliposomes with 8-azido-[gamma-32P]-ATP, which is protected by ATP but not by ADP. Adenosine Diphosphate 239-242 LOC104968582 Bos taurus 119-131 19106248-4 2009 Recombinant ALCAT1 was potently inhibited by ADP and ATP, but not by adenosine nucleotide analogs or other nucleotides, such as UTP and GTP, suggesting that ALCAT1 does not require ATP hydrolysis for its enzyme activity. Adenosine Diphosphate 45-48 lysocardiolipin acyltransferase 1 Mus musculus 157-163 3139031-5 1988 IAP-catalyzed [32P]ADP-ribosylation of membrane preparations from young and aged cultures revealed major differences between them. Adenosine Diphosphate 19-22 Cd47 molecule Rattus norvegicus 0-3 2844163-2 1988 A 5"-nucleotidase with a strong preference for AMP over IMP was characterized in homogenates and subcellular fractions of pigeon heart by using concentrations of ATP, ADP and AMP which mimicked those present in the ischaemic tissue. Adenosine Diphosphate 167-170 5' nucleotidase, ecto Rattus norvegicus 2-17 2838021-3 1988 Extra-liposomal ATP and ADP increase the Km for cytochrome c of both enzymes, but ATP acts at lower concentrations than ADP. Adenosine Diphosphate 24-27 LOC104968582 Bos taurus 48-60 2838021-3 1988 Extra-liposomal ATP and ADP increase the Km for cytochrome c of both enzymes, but ATP acts at lower concentrations than ADP. Adenosine Diphosphate 120-123 LOC104968582 Bos taurus 48-60 19338667-6 2009 It first facilitates the formation of a RecA-ssDNA presynaptic nucleoprotein filament by converting ATP to an ADP-Pi intermediate. Adenosine Diphosphate 110-113 RAD51 recombinase Homo sapiens 40-44 2967885-10 1988 In addition, if Ca2+ activates the ATPase by allowing for the strong attachment of the myosin to actin in an A.M.ADP.Pi state, it could do so before Pi release. Adenosine Diphosphate 113-116 dynein axonemal heavy chain 8 Homo sapiens 35-41 19116950-5 2009 NTPDase1 was located on neurons as well, since it was expressed by horizontal and ganglion cell processes, suggesting that nucleotides such as ATP and ADP can be hydrolyzed at the surface of these cells. Adenosine Diphosphate 151-154 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-8 2959278-6 1987 Competition is also suggested between Mg2+ and MgADP for binding to the phosphorylated form of the ATPase. Adenosine Diphosphate 47-52 dynein axonemal heavy chain 8 Homo sapiens 99-105 18798872-8 2009 The results indicate that overexpression of AtNUDX2, encoding ADP-ribose pyrophosphatase, confers enhanced tolerance of oxidative stress on Arabidopsis plants, resulting from maintenance of NAD(+) and ATP levels by nucleotide recycling from free ADP-ribose molecules under stress conditions. Adenosine Diphosphate 62-65 nudix hydrolase homolog 2 Arabidopsis thaliana 44-51 3605851-1 1987 During exercise, ATP is converted to ADP and AMP to supply energy for muscular contraction. Adenosine Diphosphate 37-40 ATPase phospholipid transporting 8A2 Homo sapiens 17-20 19073762-3 2008 Functional integration of Gm PNC1 and At PNC2 into the cytoplasmic membranes of intact Escherichia coli cells revealed ATP and ADP import activities. Adenosine Diphosphate 127-130 peroxisomal adenine nucleotide carrier 2 Arabidopsis thaliana 41-45 19073763-6 2008 Complementation of a yeast mutant deficient in peroxisomal ATP import and in vitro transport assays using recombinant transporter proteins revealed that PNC1 and PNC2 catalyze the counterexchange of ATP with ADP or AMP. Adenosine Diphosphate 208-211 peroxisomal adenine nucleotide carrier 2 Arabidopsis thaliana 162-166 18675894-5 2008 ATP-, UTP-, ADP-, 2-MeS-ATP- and ADP-betaS-induced proliferation in P19 cells was mediated by P2Y(1) and P2Y(2) receptors as judged from pharmacological profiles of receptor responses. Adenosine Diphosphate 12-15 purinergic receptor P2Y2 Homo sapiens 105-111 3593790-3 1987 The inhibitor of 5"-nucleotidase (alpha,beta-methylene)-ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by ADP, did not affect PIMOI cleavage and moderately inhibited AMP hydrolysis (by 30-50%), thus suggesting that acidic phosphatases are responsible for PIMOI and AMP hydrolysis under these conditions (pH 6.3). Adenosine Diphosphate 56-59 5' nucleotidase, ecto Rattus norvegicus 17-32 18629616-7 2008 Apparent decrease of dissociation constants for MgATP reflects effective cycling of ATP and ADP between uMtCK and adenine nucleotide translocase (ANT). Adenosine Diphosphate 92-95 creatine kinase, mitochondrial 1 Rattus norvegicus 104-109 18636751-5 2008 We found that the cdk5/p25-catalyzed phosphorylation of tau follows a rapid equilibrium, random kinetic mechanism, as evidenced by initial velocity analysis indicating sequential addition of tau and ATP, and studies of the mechanism of inhibition by substrate analogue AMP, product ADP, and analogues of peptide substrate H1P. Adenosine Diphosphate 282-285 cyclin dependent kinase 5 regulatory subunit 1 Homo sapiens 23-26 18687246-10 2008 RESULTS: Current smokers on chronic clopidogrel therapy displayed significantly lower PA and ADP-stimulated active GP IIb/IIIa expression compared with NS (p < or = 0.0008 for both). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 115-121 18537971-3 2008 The ectonucleotidase CD39/ecto-nucleoside triphosphate diphosphohydrolase1 (E-NTPDase1) modulates purinergic signalling through pericellular ATP and ADP phosphohydrolysis and is localized within lipid rafts in the membranes of endothelial- and immune cells. Adenosine Diphosphate 149-152 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 21-74 18485069-2 2008 By targeting luciferase to the mitochondrial matrix to monitor mitochondrial ATP levels, we show in isolated mitochondria that both ATP-Mg and free ADP are taken up by Sal1p with a K(m) of 0.20 +/- 0.03 mM and 0.28 +/- 0.06 mM respectively. Adenosine Diphosphate 148-151 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 168-173 23572887-2 2008 Here we describe the reversibility of the vacuolar V-type H(+)-ATPase (V-ATPase) even in the absence of the H(+) gradient in a water-Me2SO co-solvent mixture, resulting in net synthesis of [gamma-(32)P]ATP from [(32)P]Pi and ADP. Adenosine Diphosphate 225-228 V-type proton ATPase catalytic subunit A Zea mays 51-69 23572887-2 2008 Here we describe the reversibility of the vacuolar V-type H(+)-ATPase (V-ATPase) even in the absence of the H(+) gradient in a water-Me2SO co-solvent mixture, resulting in net synthesis of [gamma-(32)P]ATP from [(32)P]Pi and ADP. Adenosine Diphosphate 225-228 V-type proton ATPase catalytic subunit A Zea mays 71-79 18441369-4 2008 From these data, we infer that P(i) release commits myosin V to undergo a highly load-dependent transition from a state in which ADP is bound to both heads and its lead head trapped in a pre-powerstroke conformation. Adenosine Diphosphate 129-132 myosin VA Homo sapiens 52-60 18712091-5 2008 The level and rate of platelet aggregation induced by ADP (1.25-20 M) correlated with GP IIb-IIIa number (r from 0.315 to 0.591) and were higher in a group of donors with high in comparison with low GP IIb-IIIa content (> 60 and (40-50) x 10(3) per platelet respectively). Adenosine Diphosphate 54-57 integrin subunit alpha 2b Homo sapiens 86-92 18712091-5 2008 The level and rate of platelet aggregation induced by ADP (1.25-20 M) correlated with GP IIb-IIIa number (r from 0.315 to 0.591) and were higher in a group of donors with high in comparison with low GP IIb-IIIa content (> 60 and (40-50) x 10(3) per platelet respectively). Adenosine Diphosphate 54-57 integrin subunit alpha 2b Homo sapiens 199-205 17967437-1 2008 The goal of this investigation was to develop an assay whereby we could measure changes in ATP, ADP, and phosphocreatine (PCr) during stimulation of the sarcoplasmic reticulum (SR) Ca2+ ATPase. Adenosine Diphosphate 96-99 carbonic anhydrase 2 Homo sapiens 181-192 17825341-3 2007 In this study, we determined that purified recombinant NSP5 has a Mg2+-dependent ATP-specific triphosphatase activity that generates free ADP and Pi (Vmax of 19.33 fmol of product/min/pmol of enzyme). Adenosine Diphosphate 138-141 sperm antigen with calponin homology and coiled-coil domains 1 Homo sapiens 55-59 18004210-9 2007 The genotype distribution of CYP2C19*2 polymorphism significantly differed between patients with and without RPR, as evaluated by 10-micromol/l ADP-induced platelet aggregation (P=0.002) and by AA-induced platelet aggregation (P=0.045). Adenosine Diphosphate 144-147 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 29-36 18047806-8 2007 The inhibitory effect of chloroquine on hGDH2 was abolished, although in part, by the presence of ADP and L-leucine, whereas GTP did not change the sensitivity to chloroquine inhibition. Adenosine Diphosphate 98-101 glutamate dehydrogenase 2 Homo sapiens 40-45 3548815-1 1987 Enthalpies of binding of MgADP, MgATP, and 3-phosphoglycerate to yeast phosphoglycerate kinase have been determined by flow calorimetry at 9.95-32.00 degrees C. Combination of these data with published dissociation constants [Scopes, R.K. (1978) Eur. Adenosine Diphosphate 25-30 phosphoglycerate kinase Saccharomyces cerevisiae S288C 71-94 3800385-1 1986 This paper demonstrates that the mitochondrial isoenzyme of creatine kinase (CKm) can be solubilized from rabbit heart mitochondria, the outer membrane of which has been removed or at least broken by a digitonin treatment or a short hypotonic exposure, but which has retained an important part of the capacity to phosphorylate ADP. Adenosine Diphosphate 327-330 creatine kinase M-type Oryctolagus cuniculus 77-80 3800385-2 1986 Phosphate, ADP, or ATP, at concentrations which are used to study oxidative phosphorylation and creatine phosphate synthesis, solubilize CKm; the same is true with MgCl2 and KCl. Adenosine Diphosphate 11-14 creatine kinase M-type Oryctolagus cuniculus 137-140 3771533-8 1986 Neuraminidase treatment of ADP-perturbed washed platelets also resulted in a cathodal shift of the associated complex; however, dissociation with EGTA was inhibited. Adenosine Diphosphate 27-30 neuraminidase 1 Homo sapiens 0-13 3771533-9 1986 Thus, critical neuraminidase-sensitive components of the complex (sialic acid residues) are not exposed on the surface of the platelet membrane of resting platelets, but do become accessible following platelet stimulation with ADP or membrane solubilization with Triton X-100. Adenosine Diphosphate 227-230 neuraminidase 1 Homo sapiens 15-28 3015030-4 1986 Elution of catalase beta was also obtained with NADH, NADP+, and ADP at higher concentration. Adenosine Diphosphate 55-58 catalase Bos taurus 11-19 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 40-43 ATPase phospholipid transporting 8A2 Homo sapiens 74-77 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 40-43 ATPase phospholipid transporting 8A2 Homo sapiens 130-133 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 40-43 ATPase phospholipid transporting 8A2 Homo sapiens 130-133 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 103-106 ATPase phospholipid transporting 8A2 Homo sapiens 74-77 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 103-106 ATPase phospholipid transporting 8A2 Homo sapiens 130-133 3699030-5 1986 If it is assumed that the source of the ADP bound to F-actin is cytosolic ATP, the turnover of F-actin ADP measured represents an ATP-consuming process that would account for up to 50% of total ATP consumption in resting platelets. Adenosine Diphosphate 103-106 ATPase phospholipid transporting 8A2 Homo sapiens 130-133 17924438-5 2007 Functional analyses of highly purified recombinant wild-type hGDH2 revealed that this adaptive evolution dissociated the enzyme from GTP control, permitted regulation almost entirely by ADP and/or L-leucine, and fine-tuned its activity to the relatively low cellular pH that occurs in synaptic astrocytes during excitatory transmission. Adenosine Diphosphate 186-189 glutamate dehydrogenase 2 Homo sapiens 61-66 3705019-4 1986 Stimulation with a low dose of thrombin (0.001 U/ml) or ADP (10 microM) caused a change in shape and incorporation of ABP, myosin, and actin, but not serotonin secretion. Adenosine Diphosphate 56-59 sex hormone-binding globulin Oryctolagus cuniculus 118-121 2869031-3 1986 The blockade of SRIF"s inhibitory effect on the actions of TRH or VIP was dependent on both the duration of preincubation and concentration of the toxin and was correlated with the ability of the toxin to catalyze the ADP-ribosylation of the 39,000-Da membrane protein. Adenosine Diphosphate 218-221 thyrotropin releasing hormone Rattus norvegicus 59-62 3023860-4 1986 Gene fusions between the PET9 gene and the gene encoding beta-galactosidase (lacZ) were constructed to define the location of sequences necessary for the mitochondrial delivery of the ADP/ATP translocator protein in vivo. Adenosine Diphosphate 184-187 ADP/ATP carrier protein PET9 Saccharomyces cerevisiae S288C 25-29 17957566-7 2007 Consistent correlations were revealed between GP IIb-IIIa quantity and the level and rate of ADP-induced aggregation (r from 0.353 to 0.583, p from <0.001 to 0.037) as well as resistance (level of residual aggregation) to both GP IIb-IIIa antagonists (r from 0.345 to 0.602, p from <0.001 to 0.042). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 46-52 3936483-1 1985 We compared the effects of guanine nucleotides and Mg2+ on ADP-ribosylation of rat brain and liver membrane proteins catalysed by Bordetella pertussis toxin (IAP) and cholera toxin (CT). Adenosine Diphosphate 59-62 Cd47 molecule Rattus norvegicus 158-161 3936483-9 1985 These results suggest that the undissociated, GDP-bound, conformation of Ni, the inhibitory GTP-binding protein of adenylate cyclase, is the preferred substrate for ADP-ribosylation by IAP. Adenosine Diphosphate 165-168 Cd47 molecule Rattus norvegicus 185-188 17957566-7 2007 Consistent correlations were revealed between GP IIb-IIIa quantity and the level and rate of ADP-induced aggregation (r from 0.353 to 0.583, p from <0.001 to 0.037) as well as resistance (level of residual aggregation) to both GP IIb-IIIa antagonists (r from 0.345 to 0.602, p from <0.001 to 0.042). Adenosine Diphosphate 93-96 integrin subunit alpha 2b Homo sapiens 230-236 17961220-2 2007 The main function of PARP-1 is to catalyze the transfer of ADP-ribose units from nicotinamide adenine dinucleotide (NAD+) to a large array of acceptor proteins, which comprises histones, transcription factors, as well as PARP-1 itself. Adenosine Diphosphate 59-62 poly (ADP-ribose) polymerase family, member 1 Mus musculus 21-27 2934863-4 1985 Both prior to and after ASA ingestion ADP removal by creatine phosphate/creatine phosphokinase (CP/CPK) resulted in a reduced, reversible platelet aggregation induced by PAF alone or in combination with the other agonists. Adenosine Diphosphate 38-41 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 99-102 17961220-2 2007 The main function of PARP-1 is to catalyze the transfer of ADP-ribose units from nicotinamide adenine dinucleotide (NAD+) to a large array of acceptor proteins, which comprises histones, transcription factors, as well as PARP-1 itself. Adenosine Diphosphate 59-62 poly (ADP-ribose) polymerase family, member 1 Mus musculus 221-227 2934863-5 1985 The ADP-removal and ASA-ingestion also strongly inhibited the beta-TG release. Adenosine Diphosphate 4-7 pro-platelet basic protein Homo sapiens 62-69 17936703-4 2007 Here, we report the 2.4 A crystal structure of mammalian GRP94 in complex with AMPPNP and ADP. Adenosine Diphosphate 90-93 heat shock protein 90 beta family member 1 Homo sapiens 57-62 2934090-7 1985 The fourth mechanism considered was stimulation of ATPase activity by the binding of ATP or AMPPCP at the active site after departure of ADP but before the departure of inorganic phosphate. Adenosine Diphosphate 137-140 dynein axonemal heavy chain 8 Homo sapiens 51-57 17875745-4 2007 In living cells, cofilin is not necessary for actin assembly on endocytic membranes but is recruited to molecularly aged adenosine diphosphate actin filaments and is necessary for their rapid disassembly. Adenosine Diphosphate 121-142 cofilin Saccharomyces cerevisiae S288C 17-24 2579078-6 1985 Incubation of the supernatant fraction of mast cell homogenates with the active component of IAP caused the transfer of the ADP-ribosyl moiety of added [alpha-32P]NAD to a protein with Mr = 41,000. Adenosine Diphosphate 124-127 islet amyloid polypeptide Homo sapiens 93-96 2579078-7 1985 The IAP-catalyzed ADP-ribosylation of this protein was prevented by guanosine 5"-(3-O-thio)triphosphate, indicating that this IAP substrate resembles, in character, the alpha-subunit of the guanine nucleotide regulatory protein (Ni) involved in inhibition of adenylate cyclase. Adenosine Diphosphate 18-21 islet amyloid polypeptide Homo sapiens 4-7 2579078-7 1985 The IAP-catalyzed ADP-ribosylation of this protein was prevented by guanosine 5"-(3-O-thio)triphosphate, indicating that this IAP substrate resembles, in character, the alpha-subunit of the guanine nucleotide regulatory protein (Ni) involved in inhibition of adenylate cyclase. Adenosine Diphosphate 18-21 islet amyloid polypeptide Homo sapiens 126-129 2579078-8 1985 The degree of ADP-ribosylation of this IAP substrate was prevented progressively by pre-exposure of the homogenate-donor cells to increasing concentrations of IAP. Adenosine Diphosphate 14-17 islet amyloid polypeptide Homo sapiens 39-42 2579078-8 1985 The degree of ADP-ribosylation of this IAP substrate was prevented progressively by pre-exposure of the homogenate-donor cells to increasing concentrations of IAP. Adenosine Diphosphate 14-17 islet amyloid polypeptide Homo sapiens 159-162 3938969-10 1985 In the presence of G beta gamma and photolyzed rhodopsin, GDP and GDP beta S, but not Gpp(NH)p and GTP gamma S, increased the ADP-ribosylation of Gi alpha. Adenosine Diphosphate 126-129 succinate-CoA ligase GDP-forming subunit beta Homo sapiens 19-25 17697836-8 2007 Activation in PRP was 23 +/- 15% that in whole blood for thrombin, 65 +/- 26% for adenosine diphosphate, 40 +/- 20% for platelet activating factor, and 49 +/- 25% for convulxin (p <0.01 for each comparison). Adenosine Diphosphate 82-103 proline rich cell wall protein 1 Zea mays 14-17 6092069-5 1984 When NDP-preferring RC were incubated with ADP and three other NTP, very low concentrations of endogenously generated ATP ensured a greater rate of RNA synthesis than did much higher concentrations of exogenous ATP. Adenosine Diphosphate 43-46 norrin cystine knot growth factor NDP Homo sapiens 5-8 17393024-10 2007 On ADP-stimulated platelets the thresholds for P-selectin expression and GP IIb/IIa activation are 34.0 degrees C and 36.4 degrees C, respectively, and lie in the temperature range routinely applied in cardiac surgery. Adenosine Diphosphate 3-6 integrin subunit alpha 2b Homo sapiens 73-79 6319392-11 1984 Removal of the trace of Fru-6-P by Glu-6-P isomerase and Glu-6-P dehydrogenase reduced enzyme phosphorylation by ATP to very low levels, greatly inhibited the ATPase, and rendered it insensitive to Pi, but did not affect ADP/ATP exchange. Adenosine Diphosphate 221-224 zinc finger and BTB domain containing 22 Homo sapiens 24-27 16939417-5 2007 Depletion of the DTS using ADP, which releases Ca2+ solely from the DTS, in combination with 10 nM TG, to selectively inhibit SERCA2 located on the DTS reduced Ca2+ release evoked by the PAR-1 agonist, SFLLRN, and the PAR-4 agonist, AYPGKF, by 80 and 50% respectively. Adenosine Diphosphate 27-30 F2R like thrombin or trypsin receptor 3 Homo sapiens 218-223 17140383-0 2006 ATPase domain of Hsp70 exhibits intrinsic ATP-ADP exchange activity. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 4 Homo sapiens 17-22 6141020-7 1984 Injection of ADP (0.1 M) raises the ATP levels and reduces the ArP levels, more so in unexposed fibers. Adenosine Diphosphate 13-16 ADP ribosylation factor related protein 1 Homo sapiens 63-66 17140383-2 2006 It was reported that, in the presence of physiological concentrations of ATP (approximately 5 mM) and ADP (approximately 0.5 mM), Hsp70 catalyzes ATP-ADP exchange through transfer of gamma-phosphate between ATP and ADP, via an autophosphorylated intermediate, whereas it only catalyzes the hydrolysis of ATP in the absence of ADP. Adenosine Diphosphate 102-105 heat shock protein family A (Hsp70) member 4 Homo sapiens 130-135 6317693-9 1983 These results show that a decrease in endogenous ADP-ribosylation of HMG 14 and 17 is a consequence of glucocorticoid action and suggest that loss of (ADP-ribose)n from these proteins may be an important event in mouse mammary tumor virus gene expression. Adenosine Diphosphate 49-52 high mobility group nucleosome binding domain 1 Homo sapiens 69-75 17140383-2 2006 It was reported that, in the presence of physiological concentrations of ATP (approximately 5 mM) and ADP (approximately 0.5 mM), Hsp70 catalyzes ATP-ADP exchange through transfer of gamma-phosphate between ATP and ADP, via an autophosphorylated intermediate, whereas it only catalyzes the hydrolysis of ATP in the absence of ADP. Adenosine Diphosphate 150-153 heat shock protein family A (Hsp70) member 4 Homo sapiens 130-135 17140383-2 2006 It was reported that, in the presence of physiological concentrations of ATP (approximately 5 mM) and ADP (approximately 0.5 mM), Hsp70 catalyzes ATP-ADP exchange through transfer of gamma-phosphate between ATP and ADP, via an autophosphorylated intermediate, whereas it only catalyzes the hydrolysis of ATP in the absence of ADP. Adenosine Diphosphate 150-153 heat shock protein family A (Hsp70) member 4 Homo sapiens 130-135 17140383-2 2006 It was reported that, in the presence of physiological concentrations of ATP (approximately 5 mM) and ADP (approximately 0.5 mM), Hsp70 catalyzes ATP-ADP exchange through transfer of gamma-phosphate between ATP and ADP, via an autophosphorylated intermediate, whereas it only catalyzes the hydrolysis of ATP in the absence of ADP. Adenosine Diphosphate 150-153 heat shock protein family A (Hsp70) member 4 Homo sapiens 130-135 6315008-9 1983 The ADP-ribosylated A1 was stable at low pH, and on cleavage with BrCN, the ADP-ribose moiety was found associated with peptide Cn I, the COOH-terminal fragment of A1 subunit. Adenosine Diphosphate 4-7 5'-nucleotidase, cytosolic IA Homo sapiens 128-132 6315008-9 1983 The ADP-ribosylated A1 was stable at low pH, and on cleavage with BrCN, the ADP-ribose moiety was found associated with peptide Cn I, the COOH-terminal fragment of A1 subunit. Adenosine Diphosphate 76-79 5'-nucleotidase, cytosolic IA Homo sapiens 128-132 17140383-3 2006 To clarify the functional domain of the ATP-ADP exchange activity of Hsp70, we isolated the 44-kD ATPase domain of Hsp70 after limited proteolysis with alpha-chymotrypsin (EC 3.4.21.1). Adenosine Diphosphate 44-47 heat shock protein family A (Hsp70) member 4 Homo sapiens 69-74 6315008-10 1983 On further fragmentation with cathepsin D, a dodecapeptide containing ADP-ribose moiety was isolated whose structure was determined as: Asp-Glu-Glu-Leu-His-Arg-Gly-Tyr-Arg*-Asp-Arg-Tyr. Adenosine Diphosphate 70-73 cathepsin D Homo sapiens 30-41 17140383-3 2006 To clarify the functional domain of the ATP-ADP exchange activity of Hsp70, we isolated the 44-kD ATPase domain of Hsp70 after limited proteolysis with alpha-chymotrypsin (EC 3.4.21.1). Adenosine Diphosphate 44-47 heat shock protein family A (Hsp70) member 4 Homo sapiens 115-120 6419373-1 1983 Human Factor VIII associated von Willebrand factor (VIII:vWF) binds to human platelets in vitro only in the presence of a mediator such as ristocetin, thrombin or ADP. Adenosine Diphosphate 163-166 cytochrome c oxidase subunit 8A Homo sapiens 13-17 6419373-1 1983 Human Factor VIII associated von Willebrand factor (VIII:vWF) binds to human platelets in vitro only in the presence of a mediator such as ristocetin, thrombin or ADP. Adenosine Diphosphate 163-166 cytochrome c oxidase subunit 8A Homo sapiens 52-56 16977315-0 2006 Fast-scanning atomic force microscopy reveals the ATP/ADP-dependent conformational changes of GroEL. Adenosine Diphosphate 54-57 heat shock protein family D (Hsp60) member 1 Homo sapiens 94-99 6683482-0 1983 The A protomer of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. Adenosine Diphosphate 93-96 Cd47 molecule Rattus norvegicus 18-42 6223667-1 1983 The kinetics of reversible inactivation of chloroplast CF1-ATPase by Mg2+ and ADP was studied. Adenosine Diphosphate 78-81 dynein axonemal heavy chain 8 Homo sapiens 59-65 6223667-8 1983 It may be concluded that the Mg2+-dependent inactivation of CF1-ATPase is induced by the tightly bound ADP. Adenosine Diphosphate 103-106 dynein axonemal heavy chain 8 Homo sapiens 64-70 6654830-5 1983 ADP-ribosylation of elongation factor 2 (EF-2) catalyzed by diphtheria toxin was measured in cell-free extracts from the parent cells and 17 DTr cells, including 6 spontaneous DTr cells and 11 DTr cells induced by mutagens; the numbers of ADP-ribose molecules transfer to EF-2 in extracts of mutant cells were less than 1% of that in extract of the parent cells. Adenosine Diphosphate 0-3 elongation factor 2 Cricetulus griseus 20-39 6654830-5 1983 ADP-ribosylation of elongation factor 2 (EF-2) catalyzed by diphtheria toxin was measured in cell-free extracts from the parent cells and 17 DTr cells, including 6 spontaneous DTr cells and 11 DTr cells induced by mutagens; the numbers of ADP-ribose molecules transfer to EF-2 in extracts of mutant cells were less than 1% of that in extract of the parent cells. Adenosine Diphosphate 0-3 elongation factor 2 Cricetulus griseus 41-45 16977315-4 2006 We also caught ATP/ADP-induced open-closed conformational changes of individual GroEL in the absence of qGroES and substrate proteins. Adenosine Diphosphate 19-22 heat shock protein family D (Hsp60) member 1 Homo sapiens 80-85 16977315-5 2006 Namely, the ATP/ADP-bound GroEL can change its conformation "from closed to open" without additional ATP hydrolysis. Adenosine Diphosphate 16-19 heat shock protein family D (Hsp60) member 1 Homo sapiens 26-31 7118160-3 1982 We now report that this direct platelet activation by modified CRP results in the secretion of both platelet dense body and alpha-granule constituents, and is sensitive to non-steroidal anti-inflammatory drugs as well as the adenosine diphosphate (ADP)-removing enzyme system creatine phosphate/creatine phosphokinase. Adenosine Diphosphate 225-246 C-reactive protein Oryctolagus cuniculus 63-66 16977315-7 2006 These results indicate that GroEL has at least two distinct open-conformations in the presence of nucleotide; ATP-bound prehydrolysis open-form and ADP-bound open-form, and the ATP hydrolysis in open-form destabilizes its open-conformation and induces the "from open to closed" conformational change of GroEL. Adenosine Diphosphate 148-151 heat shock protein family D (Hsp60) member 1 Homo sapiens 28-33 7118160-3 1982 We now report that this direct platelet activation by modified CRP results in the secretion of both platelet dense body and alpha-granule constituents, and is sensitive to non-steroidal anti-inflammatory drugs as well as the adenosine diphosphate (ADP)-removing enzyme system creatine phosphate/creatine phosphokinase. Adenosine Diphosphate 248-251 C-reactive protein Oryctolagus cuniculus 63-66 16977315-7 2006 These results indicate that GroEL has at least two distinct open-conformations in the presence of nucleotide; ATP-bound prehydrolysis open-form and ADP-bound open-form, and the ATP hydrolysis in open-form destabilizes its open-conformation and induces the "from open to closed" conformational change of GroEL. Adenosine Diphosphate 148-151 heat shock protein family D (Hsp60) member 1 Homo sapiens 303-308 17060024-6 2006 In addition, the average mRNA expression of p56lck, p59fyn and zap-70 were all found to be dramatically higher in the mice immunized with only ADP/ATP carrier peptides than in the control-group. Adenosine Diphosphate 143-146 Fyn proto-oncogene Mus musculus 52-58 17060024-8 2006 We propose that the proliferation of T-cells was significantly inhibited in anti-CD4 treated mice and CD4+ T-cells may play a critical role in ADP/ATP carrier caused mouse DCM. Adenosine Diphosphate 143-146 CD4 antigen Mus musculus 81-84 17060024-8 2006 We propose that the proliferation of T-cells was significantly inhibited in anti-CD4 treated mice and CD4+ T-cells may play a critical role in ADP/ATP carrier caused mouse DCM. Adenosine Diphosphate 143-146 CD4 antigen Mus musculus 102-105 16740607-6 2006 The apparent mitochondrial Km for ADP was significantly lower in the MLP-null heart than in control (175 +/- 15 and 270 +/- 33 microM, respectively), indicating greater ADP accessibility, although maximal respiration rate, mitochondrial content and total CK activity were unaltered. Adenosine Diphosphate 34-37 cysteine and glycine-rich protein 3 Mus musculus 69-72 6288084-6 1982 Small amounts of ATP and ADP in the preincubation mixture containing dinitrophenol protected against the decay of the ATPase activity, implicating the exchangeable adenine nucleotides in the tumor mitochondria. Adenosine Diphosphate 25-28 dynein axonemal heavy chain 8 Homo sapiens 118-124 7042080-3 1982 9-beta-D-Arabinofuranosyl-2-fluoroadenine 5"-triphosphate was more effective than 9-beta-D-arabinofuranosyladenine 5"-triphosphate in inhibiting the reduction of adenosine 5"-diphosphate and cytidine 5"-diphosphate by ribonucleotide reductase from HEp-2 cells or L1210 cells. Adenosine Diphosphate 162-186 histocompatibility 51 Mus musculus 248-251 16740607-6 2006 The apparent mitochondrial Km for ADP was significantly lower in the MLP-null heart than in control (175 +/- 15 and 270 +/- 33 microM, respectively), indicating greater ADP accessibility, although maximal respiration rate, mitochondrial content and total CK activity were unaltered. Adenosine Diphosphate 169-172 cysteine and glycine-rich protein 3 Mus musculus 69-72 16806043-1 2006 Hsp70 alternates between an ATP-bound state in which the affinity for substrate is low and an ADP-bound state in which the affinity for substrate is high, as a result Hsp70 assists the protein folding process through nucleotide-controlled cycles of substrate binding and release. Adenosine Diphosphate 94-97 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 6118374-9 1982 During the catalytic cycle, Mg2+ combined with the Mg2+ site before Ca2+ dissociated from the Ca2+ transport site of the ADP-sensitive phosphoenzyme with bound Ca2+. Adenosine Diphosphate 121-124 mucin 7, secreted Homo sapiens 28-31 6118374-9 1982 During the catalytic cycle, Mg2+ combined with the Mg2+ site before Ca2+ dissociated from the Ca2+ transport site of the ADP-sensitive phosphoenzyme with bound Ca2+. Adenosine Diphosphate 121-124 mucin 7, secreted Homo sapiens 51-54 6118374-10 1982 This Mg2+ did not activate hydrolysis of the ADP-sensitive phosphoenzyme with bound Ca2+, but markedly activated hydrolysis of the ADP-insensitive phosphoenzyme without bound Ca2+. Adenosine Diphosphate 131-134 mucin 7, secreted Homo sapiens 5-8 7272509-3 1981 With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4. Adenosine Diphosphate 17-20 pro-platelet basic protein Homo sapiens 105-148 16806043-1 2006 Hsp70 alternates between an ATP-bound state in which the affinity for substrate is low and an ADP-bound state in which the affinity for substrate is high, as a result Hsp70 assists the protein folding process through nucleotide-controlled cycles of substrate binding and release. Adenosine Diphosphate 94-97 heat shock protein family A (Hsp70) member 4 Homo sapiens 167-172 16806043-2 2006 In this work, we describe the cloning and purification of the human 70-kDa heat shock cognate protein, Hsc70, and the use of circular dichroism, intrinsic emission fluorescence, and isothermal titration calorimetry to characterize conformational changes induced by ADP and ATP binding. Adenosine Diphosphate 265-268 heat shock protein family A (Hsp70) member 8 Homo sapiens 103-108 6781525-5 1981 Removal of ADP with CP/CPK decreased the adherence of gel-filtered citrated and EDTA platelets and washed EDTA platelets (P less than 0.001) but not EDTA platelets in plasma. Adenosine Diphosphate 11-14 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 23-26 16806043-5 2006 Isothermal titration calorimetry data pointed out that Hsc70 had a lower affinity for ATP (KD=710 nM) than for ADP (KD=260 nM). Adenosine Diphosphate 111-114 heat shock protein family A (Hsp70) member 8 Homo sapiens 55-60 17015265-0 2006 The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Adenosine Diphosphate 4-7 mitogen activated protein kinase kinase 4 Rattus norvegicus 53-57 6257666-3 1980 We measured the amounts of Rb+ ions (a K+ congener) as well as Na+ and K+ ions bound to the ATPase during the ATPase reaction at pH 7.5 and 0 degrees C. The affinity of the Na+-binding sites for three Na+ ions decreased markedly but that of the K+-binding sites for two K+ or Rb+ ions increased markedly upon formation of an ADP-insensitive phosphorylated intermediate. Adenosine Diphosphate 325-328 dynein axonemal heavy chain 8 Homo sapiens 92-98 6257666-6 1980 When the ATPase was treated with N-ethylmaleimide (NEM), almost all the EP formed was ADP-sensitive. Adenosine Diphosphate 86-89 dynein axonemal heavy chain 8 Homo sapiens 9-15 7407418-3 1980 Enzymatic removal of ADP with apyrase or creatine phosphate/creatine phosphokinase (CP/CPK) from thrombin-stimulated platelets markedly inhibited 125I-fibrinogen binding, but pretreatment of platelets with CP/CPK prior to thrombin stimulation was without effect. Adenosine Diphosphate 21-24 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 87-90 7407418-3 1980 Enzymatic removal of ADP with apyrase or creatine phosphate/creatine phosphokinase (CP/CPK) from thrombin-stimulated platelets markedly inhibited 125I-fibrinogen binding, but pretreatment of platelets with CP/CPK prior to thrombin stimulation was without effect. Adenosine Diphosphate 21-24 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 209-212 16624636-0 2006 Magnesium influences the discrimination and release of ADP by human RAD51. Adenosine Diphosphate 55-58 RAD51 recombinase Homo sapiens 68-73 44195-6 1979 Glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, isocitrate dehydrogenase and "malic" enzyme, partially purified from livers of phenobarbital-treated rats, were inhibited by ATP and ADP. Adenosine Diphosphate 202-205 glucose-6-phosphate dehydrogenase Rattus norvegicus 0-33 44195-9 1979 Concentrations of ATP and ADP that inhibited glucose 6-phosphate dehydrogenase and the reductase were comparable with concentrations in the intact liver. Adenosine Diphosphate 26-29 glucose-6-phosphate dehydrogenase Rattus norvegicus 45-78 16644292-17 2006 In addition we observed an induced stability of the hRAD51-DNA complex in the presence of ATP that becomes unstable following ATP hydrolysis (the ADP form or nucleotide free form). Adenosine Diphosphate 146-149 RAD51 recombinase Homo sapiens 52-58 494060-3 1979 Their entire complement of EF-2 is susceptible to ADP-ribosylation by toxin. Adenosine Diphosphate 50-53 elongation factor 2 Cricetulus griseus 27-31 16643434-5 2006 High glucose levels enhanced adenosine diphosphate (ADP)- and thrombin receptor-activating peptide (TRAP)-induced platelet P-selectin expression, and TRAP-induced platelet fibrinogen binding. Adenosine Diphosphate 29-50 TRAP Homo sapiens 100-104 156022-6 1979 Incubation of submitochondrial particles or soluble mitochondrial ATPase with the mixed anhydride of ADP and mesitylenecarboxylic acid results in AMP formation. Adenosine Diphosphate 101-104 ATP synthase F1 subunit epsilon Homo sapiens 52-72 16630281-0 2006 Heterologous complementation of the Klaac null mutation of Kluyveromyces lactis by the Saccharomyces cerevisiae AAC3 gene encoding the ADP/ATP carrier. Adenosine Diphosphate 135-138 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 112-116 16177811-1 2006 Poly(ADP-ribose) (PAR) is a polymer synthesized by poly(ADP-ribose) polymerases (PARPs) and metabolized into free adenosine diphosphate (ADP)-ribose units by poly(ADP-ribose) glycohydrolase (PARG). Adenosine Diphosphate 114-135 poly (ADP-ribose) polymerase family, member 1 Mus musculus 81-86 154160-2 1978 ATP synthesis would take place on a catalytic site of ATPase constituted by two irons with ligands ATP, ADP, and Pi. Adenosine Diphosphate 104-107 dynein axonemal heavy chain 8 Homo sapiens 54-60 694729-5 1978 According to this view, the mutated allele produces EF-2 resistant to ADP-ribosylation which is capable of supporting cell growth in the presence of diphtheria toxin. Adenosine Diphosphate 70-73 elongation factor 2 Cricetulus griseus 52-56 16177811-1 2006 Poly(ADP-ribose) (PAR) is a polymer synthesized by poly(ADP-ribose) polymerases (PARPs) and metabolized into free adenosine diphosphate (ADP)-ribose units by poly(ADP-ribose) glycohydrolase (PARG). Adenosine Diphosphate 114-135 poly (ADP-ribose) glycohydrolase Mus musculus 158-189 16177811-1 2006 Poly(ADP-ribose) (PAR) is a polymer synthesized by poly(ADP-ribose) polymerases (PARPs) and metabolized into free adenosine diphosphate (ADP)-ribose units by poly(ADP-ribose) glycohydrolase (PARG). Adenosine Diphosphate 114-135 poly (ADP-ribose) glycohydrolase Mus musculus 191-195 28787-3 1978 Comparison of the stepwise Mg2+ stability constants (log k = 3.2 and 1.6) with those of MgADP- and MgAMP or Mg-hexose-1-P suggests that the first and second Mg2+ bind to the 1-PP and 5-P groups of the ligand, respectively. Adenosine Diphosphate 88-93 mucin 7, secreted Homo sapiens 27-30 16634757-5 2006 Conversely, the platelet shape change promoted by ADP in the presence of the GPIIb/IIIa antagonist eptifibatide was similar to that promoted by MRS2365. Adenosine Diphosphate 50-53 integrin subunit alpha 2b Homo sapiens 77-82 28787-3 1978 Comparison of the stepwise Mg2+ stability constants (log k = 3.2 and 1.6) with those of MgADP- and MgAMP or Mg-hexose-1-P suggests that the first and second Mg2+ bind to the 1-PP and 5-P groups of the ligand, respectively. Adenosine Diphosphate 88-93 mucin 7, secreted Homo sapiens 157-160 16476557-6 2006 CD39/NTPDase1 hydrolyzes both tri- and diphosphonucleosides and blocks platelet aggregation responses to ADP. Adenosine Diphosphate 105-108 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 16476557-6 2006 CD39/NTPDase1 hydrolyzes both tri- and diphosphonucleosides and blocks platelet aggregation responses to ADP. Adenosine Diphosphate 105-108 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 5-13 18351-6 1977 As in the case of ATP and ADP, the association of Mg2+ reduces the pK by about 1.5 units. Adenosine Diphosphate 26-29 mucin 7, secreted Homo sapiens 50-53 16792915-5 2006 RESULTS: (1) Anti-platelet GPIIb/IIIa and/or GPIb/IX autoantibodies were detected in 34 of 68 (53.6%) ITP patients" plasmas and that from 5 patients significantly inhibited the platelet aggregation induced by ADP or ristocetin. Adenosine Diphosphate 209-212 integrin subunit alpha 2b Homo sapiens 27-32 15595-3 1977 Reversal of the inhibitory effect of ADP on Ehrlich ascites cell mitochondria ATPase by an ATP-regenerating system was achieved. Adenosine Diphosphate 37-40 dynein, axonemal, heavy chain 8 Mus musculus 78-84 16111475-7 2005 Our results also suggest that Sal1p is a target of the glucose-induced calcium signal which is non-essential in wild-type cells, but becomes essential for transport of ATP into mitochondria in yeast lacking ADP/ATP translocases. Adenosine Diphosphate 207-210 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 30-35 14328-1 1977 The interaction of Mg2+ with nucleoside disphosphates : ADP, GDP, CDP and UDP has been studied by phosphorus magnetic resonance spectroscopy in aqueous solution. Adenosine Diphosphate 56-59 mucin 7, secreted Homo sapiens 19-22 818325-11 1976 Addition of thrombin (1 U. per milliliter) liberated all of the PF4 antigen (78 +/- 24 mug) present in PRP but ADP (50 muM) released only 31 +/- 22 mug of PF4 antigen per 10(9) platelets. Adenosine Diphosphate 111-114 platelet factor 4 Homo sapiens 155-158 16027167-6 2005 ADP and AMP had similar effects to ATP, but IMP had no effect, indicating that the inhibition of ClC-1 would only be relieved under anaerobic conditions such as intense muscle activity or ischemia, when depleted ATP accumulates as IMP. Adenosine Diphosphate 0-3 chloride voltage-gated channel 1 Homo sapiens 97-102 131572-7 1976 Use of a removable skull capsule allowed serial observations on individual animals and these, together with observations on rabbits injected first with alloxan and later with daily insulin, showed reversibility of the increased ADP sensitivity by regular insulin injection for at least 5 days; this effect did not depend upon return of blood glucose levels to normal. Adenosine Diphosphate 228-231 insulin Oryctolagus cuniculus 181-188 131572-7 1976 Use of a removable skull capsule allowed serial observations on individual animals and these, together with observations on rabbits injected first with alloxan and later with daily insulin, showed reversibility of the increased ADP sensitivity by regular insulin injection for at least 5 days; this effect did not depend upon return of blood glucose levels to normal. Adenosine Diphosphate 228-231 insulin Oryctolagus cuniculus 255-262 127622-1 1975 ATP, added to the solution bathing the nutrient (serosal) surface of isolated frog gastric mucosa, was found to break down rapidly to ADP, inorganic phosphate and other products. Adenosine Diphosphate 134-137 ATPase phospholipid transporting 8A2 Homo sapiens 0-3 123785-3 1975 Membranes washed several times still contain 2.5 nmol ATP and 1.3 nmol ADP bound per mg chlorophyll, which is equivalent to 1.9 ATP and 1.0 ADP per coupling ATPase. Adenosine Diphosphate 140-143 ATPase phospholipid transporting 8A2 Homo sapiens 54-57 15893323-4 2005 K(ATP) channels generated from coexpression of Kir6.2 with SUR1 exhibit greater MgADP stimulation than channels generated from coexpression of Kir6.2 with SUR2A. Adenosine Diphosphate 80-85 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 47-53 18404510-6 2005 Rat NTPDase3 expressed in CHO cells hydrolyzed both nucleoside triphosphates and nucleoside diphosphates with hydrolysis ratios of ATP:ADP of 5:1 and UTP:UDP of 8:1. Adenosine Diphosphate 135-138 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 4-12 238840-7 1975 The fluorescence of the N-nitrobenzofurazan group in the modified ATPase is quenched on binding of ADP. Adenosine Diphosphate 99-102 dynein axonemal heavy chain 8 Homo sapiens 66-72 1147907-6 1975 Activation of respiration by either ADP or uncoupling agent resulted in a decreased content of citrate and isocitrate and an increased content of 2-oxoglutarate and malate when the substrate was pyruvate, APT and HCO3 minus. Adenosine Diphosphate 36-39 apontic Drosophila melanogaster 205-208 15952789-0 2005 Magnesium, ADP, and actin binding linkage of myosin V: evidence for multiple myosin V-ADP and actomyosin V-ADP states. Adenosine Diphosphate 11-14 myosin VA Homo sapiens 45-53 126626-7 1975 Under these conditions the whole chain velocity is mainly dependent on the 5"-nucleotidase concentration, because ATPases and adenylate kinase remove the nucleotidase inhibitors ATP and ADP spontanously. Adenosine Diphosphate 186-189 5'-nucleotidase ecto Homo sapiens 75-90 15952789-1 2005 The [Mg(2+)] dependence of ADP binding to myosin V and actomyosin V was measured from the fluorescence of mantADP. Adenosine Diphosphate 27-30 myosin VA Homo sapiens 42-50 15952789-4 2005 The two myosin V-MgADP states are of comparable energies, as indicated by the relatively equimolar partitioning at saturating magnesium. Adenosine Diphosphate 17-22 myosin VA Homo sapiens 8-16 15952789-7 2005 Myosin V and myosin V-ADP binding to actin was assayed from the quenching of pyrene actin fluorescence. Adenosine Diphosphate 22-25 myosin VA Homo sapiens 13-21 4268896-6 1973 Short treatment of platelets with plasmin enhanced their sensitivity to ADP; however, this sensitivity was lost during longer incubation with plasmin. Adenosine Diphosphate 72-75 plasminogen Homo sapiens 34-41 15958743-3 2005 Using current-clamp recordings in hippocampal slices, we find that the ADP in CA1 pyramidal neurons is mediated by an Ni2+-sensitive calcium tail current. Adenosine Diphosphate 71-74 carbonic anhydrase 1 Homo sapiens 78-81 4257817-3 1972 With E. coli DNA as substrate, 8-9 molecules of ATP are hydrolyzed to ADP and inorganic phosphate for every phosphodiester bond hydrolyzed by the DNase. Adenosine Diphosphate 70-73 colicin E8 Escherichia coli 146-151 15958743-6 2005 Because the ADP correlates directly with burst firing in CA1 neurons, R-type calcium channels are crucial to this important cellular behavior, which is known to encode hippocampal place fields and enhance synaptic plasticity. Adenosine Diphosphate 12-15 carbonic anhydrase 1 Homo sapiens 57-60 15955470-5 2005 While the platelet count was similar in both groups, platelet sensitivity to stimulators was reduced in group 1 (P-selectin and activated GP IIb/IIIa on ADP-stimulated platelets, p < or = 0.01). Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 138-144 4254539-1 1971 V. Vectorial requirements for calcium and magnesium ions of three partial reactions of ATPase: formation and decomposition of a phosphorylated intermediate and ATP-formation from ADP and the intermediate. Adenosine Diphosphate 179-182 dynein axonemal heavy chain 8 Homo sapiens 87-93 15757911-10 2005 These results are interpreted in light of the homology model of CAC based on the available x-ray structure of the ADP/ATP carrier. Adenosine Diphosphate 114-117 solute carrier family 25 member 20 Rattus norvegicus 64-67 5822598-6 1969 Activation of GR by FAD can be inhibited by adenosine triphosphate (ATP), and to a lesser extent by adenosine diphosphate (ADP) and adenosine monophosphate (AMP), if these adenine nucleotides are added before the addition of FAD, but only to a slight extent if FAD is added before the adenine nucleotides. Adenosine Diphosphate 100-121 glutathione-disulfide reductase Homo sapiens 14-16 5822598-6 1969 Activation of GR by FAD can be inhibited by adenosine triphosphate (ATP), and to a lesser extent by adenosine diphosphate (ADP) and adenosine monophosphate (AMP), if these adenine nucleotides are added before the addition of FAD, but only to a slight extent if FAD is added before the adenine nucleotides. Adenosine Diphosphate 123-126 glutathione-disulfide reductase Homo sapiens 14-16 4241910-6 1969 Apparently an ATPase is activated by depolarization; the resulting ADP is probably the trigger for the increase in oxygen uptake.3. Adenosine Diphosphate 67-70 dynein axonemal heavy chain 8 Homo sapiens 14-20 15632415-5 2005 NTPDase1 has identity with CD39, a B lymphocyte activation marker, and hydrolyzes extracellular ATP and ADP to AMP within the vasculature, whereas NTPDase2/CD39L(ike)1 preferentially converts ATP to ADP outside of blood vessels. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-8 5820645-7 1969 The inhibition of citrate synthase by ATP, ADP and AMP is competitive with respect to acetyl-CoA. Adenosine Diphosphate 43-46 citrate synthase Rattus norvegicus 18-34 5820645-16 1969 At constant total adenine nucleotide concentration made up of various proportions of ATP, ADP and AMP, the activity of citrate synthase is governed by the concentration of the sum of the energy-rich phosphate bonds of ADP and ATP. Adenosine Diphosphate 90-93 citrate synthase Rattus norvegicus 119-135 5820645-16 1969 At constant total adenine nucleotide concentration made up of various proportions of ATP, ADP and AMP, the activity of citrate synthase is governed by the concentration of the sum of the energy-rich phosphate bonds of ADP and ATP. Adenosine Diphosphate 218-221 citrate synthase Rattus norvegicus 119-135 15632415-5 2005 NTPDase1 has identity with CD39, a B lymphocyte activation marker, and hydrolyzes extracellular ATP and ADP to AMP within the vasculature, whereas NTPDase2/CD39L(ike)1 preferentially converts ATP to ADP outside of blood vessels. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 27-31 15632415-5 2005 NTPDase1 has identity with CD39, a B lymphocyte activation marker, and hydrolyzes extracellular ATP and ADP to AMP within the vasculature, whereas NTPDase2/CD39L(ike)1 preferentially converts ATP to ADP outside of blood vessels. Adenosine Diphosphate 199-202 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-8 15733060-10 2005 Interestingly, adenosine diphosphate (ADP)-induced platelet aggregation was significantly increased in Vn-/- platelet-rich plasma (PRP) and this effect was attenuated by adding purified plasma Vn. Adenosine Diphosphate 15-36 vitronectin Mus musculus 103-105 33309519-6 2021 The antagonism of platelet P2Y12 receptors by cangrelor, ticagrelor or active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel reduces the ADP-induced platelet aggregation in patients with thrombotic complications of vascular diseases. Adenosine Diphosphate 173-176 purinergic receptor P2Y12 Homo sapiens 27-32 33460629-1 2021 CD39 and CD73 control cell immunity by hydrolyzing proinflammatory ATP and ADP (CD39) into AMP, subsequently converted into anti-inflammatory adenosine (CD73). Adenosine Diphosphate 75-78 5'-nucleotidase ecto Homo sapiens 9-13 33460629-1 2021 CD39 and CD73 control cell immunity by hydrolyzing proinflammatory ATP and ADP (CD39) into AMP, subsequently converted into anti-inflammatory adenosine (CD73). Adenosine Diphosphate 75-78 5'-nucleotidase ecto Homo sapiens 153-157 32979284-6 2021 ATP hydrolysis drives substrate release and resets Bcs1 conformation back to the apo/ADP form. Adenosine Diphosphate 85-88 bifunctional AAA family ATPase chaperone/translocase BCS1 Saccharomyces cerevisiae S288C 51-55 15733060-10 2005 Interestingly, adenosine diphosphate (ADP)-induced platelet aggregation was significantly increased in Vn-/- platelet-rich plasma (PRP) and this effect was attenuated by adding purified plasma Vn. Adenosine Diphosphate 38-41 vitronectin Mus musculus 103-105 15705568-4 2005 Two different ADP states of myosin X are populated in the absence of actin, one of which shows very similar kinetic properties to actomyosin.ADP. Adenosine Diphosphate 14-17 myosin X Homo sapiens 28-36 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 platelet and endothelial cell adhesion molecule 1 Homo sapiens 79-86 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 platelet and endothelial cell adhesion molecule 1 Homo sapiens 156-163 15705568-4 2005 Two different ADP states of myosin X are populated in the absence of actin, one of which shows very similar kinetic properties to actomyosin.ADP. Adenosine Diphosphate 141-144 myosin X Homo sapiens 28-36 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 platelet and endothelial cell adhesion molecule 1 Homo sapiens 156-163 15680468-6 2005 ADP (30 microM) also caused an increase in ANP release with similarity to ATP, but alpha,beta-methylene ATP (alpha,beta-MeATP, P2X1 receptor agonist) and 2-methylthioADP (2-MesADP, P2Y1 receptor agonist) did not. Adenosine Diphosphate 0-3 natriuretic peptide A Rattus norvegicus 43-46 15680468-7 2005 The rank order of potency for the increment of ANP release was adenosine>ATP=ADP>2-MesADP>alpha,beta-MeATP. Adenosine Diphosphate 80-83 natriuretic peptide A Rattus norvegicus 47-50 33652345-5 2021 RESULTS: As to preceding medicines, the proportion of patients who were functionally independent (mRS 0-2) at discharge was higher in preceding P2Y12 inhibitor that suppressed ADP- and collagen-induced macro-aggregation of platelet and Xa inhibitor or warfarin in cardioembolic stroke, but lower in P2Y12 inhibitor and Xa inhibitor or warfarin in lacunar stroke compared with no medicine. Adenosine Diphosphate 176-179 purinergic receptor P2Y12 Homo sapiens 144-149 15743878-6 2005 Positional cloning identified VAN3 as a gene that encodes an adenosine diphosphate (ADP)-ribosylation factor-guanosine triphosphatase (GTPase) activating protein (ARF-GAP). Adenosine Diphosphate 61-82 ARF GTPase-activating protein Arabidopsis thaliana 30-34 33652345-5 2021 RESULTS: As to preceding medicines, the proportion of patients who were functionally independent (mRS 0-2) at discharge was higher in preceding P2Y12 inhibitor that suppressed ADP- and collagen-induced macro-aggregation of platelet and Xa inhibitor or warfarin in cardioembolic stroke, but lower in P2Y12 inhibitor and Xa inhibitor or warfarin in lacunar stroke compared with no medicine. Adenosine Diphosphate 176-179 purinergic receptor P2Y12 Homo sapiens 299-304 15743878-6 2005 Positional cloning identified VAN3 as a gene that encodes an adenosine diphosphate (ADP)-ribosylation factor-guanosine triphosphatase (GTPase) activating protein (ARF-GAP). Adenosine Diphosphate 84-87 ARF GTPase-activating protein Arabidopsis thaliana 30-34 33908345-4 2021 These structures, together with in vivo and in vitro functional analyses, support a model in which ATP-loaded RIO1 cooperates with ribosomal protein RPS26/eS26 to displace DIM2 from the 18S rRNA 3" end, thereby triggering final cleavage by NOB1; release of ADP then leads to RIO1 dissociation from the 40S subunit. Adenosine Diphosphate 257-260 thioredoxin like 4B Homo sapiens 172-176 15578726-5 2005 The GLUD2-derived GDH shows low basal activity and has the capacity to be activated fully by ADP or L-leucine. Adenosine Diphosphate 93-96 glutamate dehydrogenase 2 Homo sapiens 4-9 15485840-2 2004 Specifically, tin-9.1 and tin-10 RNA interference (RNAi) treatment of nematodes impairs import of the ADP/ATP carrier into isolated mitochondria. Adenosine Diphosphate 102-105 Mitochondrial import inner membrane translocase subunit Tim10 Caenorhabditis elegans 26-32 15654516-7 2004 Moreover, glucosamine significantly repressed the intracellular calcium mobilization at >0.1 mM and phosphorylation of Syk at >0.01 mM upon ADP-stimulation (p < 0.05). Adenosine Diphosphate 146-149 spleen associated tyrosine kinase Homo sapiens 122-125 15364914-12 2004 In aggregate, our results demonstrate that MRP4 exhibits substrate-stimulated ATP hydrolysis, and we propose a kinetic scheme suggesting that ADP release from the post-hydrolysis transition state may be the rate-limiting step during the catalytic cycle. Adenosine Diphosphate 142-145 ATP binding cassette subfamily C member 4 Homo sapiens 43-47 15505213-7 2004 ADP binds Arp3 in a unique conformation that favors an open cleft, revealing a conformational change that may occur in actin and Arps when ATP is hydrolyzed and phosphate dissociates. Adenosine Diphosphate 0-3 actin related protein 3 Homo sapiens 10-14 15476209-3 2004 Pairs of monoclonal antibodies that induced a high-fluorescence resonance energy transfer (FRET) efficiency served as tools to detect activation-dependent changes of GP IIb after addition of adenosine diphosphate and several fibans. Adenosine Diphosphate 191-212 integrin subunit alpha 2b Homo sapiens 166-172 15461628-3 2004 This is caused by an autoantibody with specificity for platelet GP IIb/IIIa or an epitope close to that of the GP, resulting in partial or complete refractoriness of the patient"s platelets to ADP, collagen and arachidonic acid. Adenosine Diphosphate 193-196 integrin subunit alpha 2b Homo sapiens 64-70 15489954-1 2004 Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). Adenosine Diphosphate 4-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 91-120 15489954-1 2004 Poly(ADP-ribosyl)ation is rapidly formed in cells following DNA damage and is regulated by poly(ADP-ribose) polymerase-1 (PARP-1). Adenosine Diphosphate 4-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 122-128 15313620-4 2004 In the ADP-AlFx/GroES-bound folding-active state the dynamic modes of the apical domains become reoriented and coupled to the motions of bound GroES. Adenosine Diphosphate 7-10 chaperonin GroES Escherichia coli 16-21 15313620-4 2004 In the ADP-AlFx/GroES-bound folding-active state the dynamic modes of the apical domains become reoriented and coupled to the motions of bound GroES. Adenosine Diphosphate 7-10 chaperonin GroES Escherichia coli 143-148 15487851-6 2004 Clopidogrel has additional effects on the ADP-induced expression of adhesion molecules (P-selectin, GPIIb/IIIa) and inflammatory mediators (CD40L). Adenosine Diphosphate 42-45 integrin subunit alpha 2b Homo sapiens 100-105 15123651-0 2004 hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. Adenosine Diphosphate 16-19 RAD51 recombinase Homo sapiens 58-64 15123651-2 2004 Yet hRAD51 lacks the coordinated ADP/ATP processing exhibited by RecA and is less efficient in HRR reactions in vitro. Adenosine Diphosphate 33-36 RAD51 recombinase Homo sapiens 4-10 15236592-6 2004 We report that apo-GRP94 undergoes a time- and temperature-dependent tertiary conformational change that exposes a site(s) of protein-protein interaction; ATP, ADP, and radicicol markedly suppress this conformational change. Adenosine Diphosphate 160-163 heat shock protein 90 beta family member 1 Homo sapiens 19-24 15236592-7 2004 In concert with these findings, ATP and ADP act identically to suppress GRP94 homooligomerization, as well as both local and global conformational activity. Adenosine Diphosphate 40-43 heat shock protein 90 beta family member 1 Homo sapiens 72-77 15236592-9 2004 Whereas ATP elicited efficient release of BiP from both wild-type and mutant Ig heavy chain intermediates, GRP94 remained in stable association with Ig heavy chains in the presence of ATP or ADP. Adenosine Diphosphate 191-194 heat shock protein 90 beta family member 1 Homo sapiens 107-112 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Adenosine Diphosphate 127-130 RAD51 recombinase Homo sapiens 58-64 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Adenosine Diphosphate 127-130 RAD51 recombinase Homo sapiens 120-126 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Adenosine Diphosphate 207-210 RAD51 recombinase Homo sapiens 58-64 15226506-6 2004 Our data demonstrate that, in the presence of Mg(2+), the hRad51-ATP-ssDNA filament is quickly converted to an inactive hRad51-ADP-ssDNA form, due to relatively rapid ATP hydrolysis and slow dissociation of ADP. Adenosine Diphosphate 207-210 RAD51 recombinase Homo sapiens 120-126 15078882-7 2004 In the presence of the ADP scavengers apyrase or phosphocreatine-phosphocreatine kinase, activation of Rap1B induced by stimulation of either PAR-1 or PAR-4 was totally inhibited. Adenosine Diphosphate 23-26 F2R like thrombin or trypsin receptor 3 Homo sapiens 151-156 15078882-9 2004 Concomitant stimulation of both PAR-1 and PAR-4 in the presence of ADP scavengers still resulted in a strongly reduced activation of Rap1B. Adenosine Diphosphate 67-70 F2R like thrombin or trypsin receptor 3 Homo sapiens 42-47 15129165-5 2004 These results suggest that ATP released from LPS-activated microglia and/or a metabolite of ATP (ADP) may induce IL-10 expression through P2Y purinergic receptors. Adenosine Diphosphate 97-100 interleukin 10 Homo sapiens 113-118 15111060-7 2004 The observation that both the ATP-induced and ADP-induced conformational rearrangements occur more rapidly in the SR1 than they do in wild-type GroEL, indicates that intra-ring conformational changes in the double-ring structure must overcome conformational constraints provided by the presence of the second ring. Adenosine Diphosphate 46-49 heat shock protein family D (Hsp60) member 1 Homo sapiens 144-149 15111061-4 2004 The slow phase is absent when double-ring or single-ring forms of GroEL are mixed with ADP or ATP without K(+), and it has a rate constant that is independent of ATP concentration. Adenosine Diphosphate 87-90 heat shock protein family D (Hsp60) member 1 Homo sapiens 66-71 15016764-5 2004 The efficiency of ATP and ADP transport was variably affected by the different AAC2 mutations. Adenosine Diphosphate 26-29 solute carrier family 25 member 5 Homo sapiens 79-83 33925516-1 2021 Recently, we found that the expressions of adenosine (ADO) receptors A2AR and A2BR and the ectonucleotidase CD73 which is needed for the conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and the extracellular ADO level are increased in TNBC MDA-MB-231 cells and RT-R-MDA-MB-231 cells compared to normal cells or non-TNBC cells. Adenosine Diphosphate 206-209 5'-nucleotidase ecto Homo sapiens 108-112 33986729-8 2021 In the circulation, gluconeogenic hormones including glucagon and corticosterone were elevated by ADP. Adenosine Diphosphate 98-101 glucagon Mus musculus 53-61 15016764-6 2004 However, irrespective of the absolute level of activity, the AAC2 pathogenic mutants showed a significant defect in ADP versus ATP transport compared with wild-type AAC2. Adenosine Diphosphate 116-119 solute carrier family 25 member 5 Homo sapiens 61-65 15146241-2 2004 CD39, the major vascular nucleoside triphosphate diphosphohydrolase (NTPDase), converts ATP and ADP to AMP, which is further degraded to the antithrombotic and anti-inflammatory mediator adenosine. Adenosine Diphosphate 96-99 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 33599725-6 2021 The purified adk-mUBA1 protein was functional for ubiquitination and could use ATP in addition to ADP as energy supply and had a higher catalytic activity than mUBA1 in cell lysis. Adenosine Diphosphate 98-101 adenosine kinase Mus musculus 13-16 33599725-6 2021 The purified adk-mUBA1 protein was functional for ubiquitination and could use ATP in addition to ADP as energy supply and had a higher catalytic activity than mUBA1 in cell lysis. Adenosine Diphosphate 98-101 ubiquitin-like modifier activating enzyme 1 Mus musculus 17-22 15102948-8 2004 Thus, the SUR2A/Kir6.2 channels" response to nicorandil critically depends on ATP-NBD1 interaction and is facilitated by interactions of ATP or ADP with NBD2. Adenosine Diphosphate 144-147 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 16-22 33921540-0 2021 Phosphorylation, Mg-ADP, and Inhibitors Differentially Shape the Conformational Dynamics of the A-Loop of Aurora-A. Adenosine Diphosphate 17-23 aurora kinase A Homo sapiens 106-114 15102948-12 2004 Thus, NBD2 hydrolyzes ATP, and NBD1 and NBD2 equally contribute to the response by interacting with ATP and ADP, accounting for the higher nicorandil sensitivity of SUR2B/Kir6.2 than SUR2A/Kir6.2 channels in the presence of ATP alone. Adenosine Diphosphate 108-111 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 171-177 14722069-1 2004 To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.PLP, and PLK.ADP complexes. Adenosine Diphosphate 162-165 polo like kinase 1 Homo sapiens 67-91 33911929-11 2021 The nucleotide-binding mode at the catalytic pocket of VCP and its three variants at codon 155 showed change in the structure, which affects the ATP-ADP transition kinetics in all the three variants. Adenosine Diphosphate 149-152 valosin containing protein Homo sapiens 55-58 33626394-6 2021 SIGNIFICANCE: Short-term standard alcohol consumption would significantly enhance suppression of ADP-induced platelet aggregation and activation by clopidogrel through significant inhibition of Nrf2/Ces1 signaling pathway and induction of Cyp2c, suggesting that alcohol may interact with drugs that are predominantly metabolized by CES1 or CYP2C in patient care, including clopidogrel. Adenosine Diphosphate 97-100 carboxylesterase 1 Homo sapiens 199-203 14722069-1 2004 To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.PLP, and PLK.ADP complexes. Adenosine Diphosphate 162-165 pyridoxal kinase Homo sapiens 85-88 33626394-6 2021 SIGNIFICANCE: Short-term standard alcohol consumption would significantly enhance suppression of ADP-induced platelet aggregation and activation by clopidogrel through significant inhibition of Nrf2/Ces1 signaling pathway and induction of Cyp2c, suggesting that alcohol may interact with drugs that are predominantly metabolized by CES1 or CYP2C in patient care, including clopidogrel. Adenosine Diphosphate 97-100 carboxylesterase 1 Homo sapiens 332-336 33530558-2 2021 In this work, we use a combination of homology modelling and subsequent microsecond molecular dynamics simulations of UCP2 in the DOPC phospholipid bilayer, starting from the structure of the mitochondrial ATP/ADP carrier (ANT) as a template. Adenosine Diphosphate 210-213 uncoupling protein 2 Homo sapiens 118-122 14722069-1 2004 To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.PLP, and PLK.ADP complexes. Adenosine Diphosphate 162-165 pyridoxal kinase Homo sapiens 132-135 33553158-2 2020 Regulatory/effector cell balance is governed by the CD39 ectonucleotidase, the prototype member of the NTPDase family that hydrolyzes ATP and ADP into AMP, subsequently converted into adenosine by CD73. Adenosine Diphosphate 142-145 5'-nucleotidase ecto Homo sapiens 197-201 14722069-1 2004 To understand the processes involved in the catalytic mechanism of pyridoxal kinase (PLK),1 we determined the crystal structures of PLK.AMP-PCP-pyridoxamine, PLK.ADP.PLP, and PLK.ADP complexes. Adenosine Diphosphate 162-165 pyridoxal kinase Homo sapiens 132-135 14754883-5 2004 Moreover, phosphoenzyme processing was affected by some of the latter mutations, in particular leucine substitution of Asp59, and alanine substitution of Leu65 accelerated the transition to ADP-insensitive phosphoenzyme and blocked its dephosphorylation, thus demonstrating that this part of M1, besides being important in Ca2+ interaction, furthermore, is a critical element in the long range signaling between the transmembrane domain and the cytoplasmic catalytic site. Adenosine Diphosphate 190-193 carbonic anhydrase 2 Homo sapiens 323-326 32653886-2 2021 OBJECTIVE: This study aims to investigate the effects of GAG from Urechis unicinctus on ADP-induced platelet calcium and membrane glycoprotein expressions in rats. Adenosine Diphosphate 88-91 CD86 molecule Rattus norvegicus 121-142 32653886-6 2021 CONCLUSIONS: This study indicated that GAG may inhibit platelet activation and aggregation by reducing the release of Ca2+ and ADP-induced expression of platelet membrane glycoprotein in rats. Adenosine Diphosphate 127-130 CD86 molecule Rattus norvegicus 162-183 33641653-8 2021 Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. Adenosine Diphosphate 31-34 von Hippel-Lindau tumor suppressor Homo sapiens 98-101 15014434-4 2004 Our results support a model in which Myo1c possesses a strain-sensing ADP-release mechanism, which allows it to adapt to mechanical load. Adenosine Diphosphate 70-73 myosin IC Mus musculus 37-42 31949019-6 2021 The differential effect of Btk inhibition in CLEC-2 relative to GPVI signalling is explained by the positive feedback role involving Btk itself, as well as ADP and thromboxane A2 mediated activation of P2Y12 and TP receptors, respectively. Adenosine Diphosphate 156-159 purinergic receptor P2Y12 Homo sapiens 202-207 15194228-9 2004 The reduction of ADP activation in D172Y mutant was more profoundly observed in hGDH2 than in hGDH1. Adenosine Diphosphate 17-20 glutamate dehydrogenase 2 Homo sapiens 80-85 33047470-9 2021 Moreover, PAC-1 binding assays on platelet activation showed an increase response to ADP exacerbated by the tagging of proteins with dimedone. Adenosine Diphosphate 85-88 dual specificity phosphatase 2 Homo sapiens 10-15 14694149-1 2004 Purinergic receptors are a family of ubiquitous transmembrane receptors comprising two classes, P1 and P2 receptors, which are activated by adenosine and extracellular nucleotides (i.e. ATP, ADP, UTP and UDP), respectively. Adenosine Diphosphate 191-194 crystallin gamma F, pseudogene Homo sapiens 96-115 15052340-4 2004 The two mammalian phospholipase D isoforms are regulated by protein kinases and GTP binding proteins of the ADP-ribosylation and Rho families. Adenosine Diphosphate 108-111 phospholipase D Saccharomyces cerevisiae S288C 18-33 32958886-1 2020 The ATPase-catalysed conversion of ATP to ADP is a fundamental process in biology. Adenosine Diphosphate 42-45 dynein axonemal heavy chain 8 Homo sapiens 4-10 14688327-2 2004 By coimmunoprecipitation, we found that MBP is associated with hsp70 in APC in an ATP/ADP-dependent manner. Adenosine Diphosphate 86-89 heat shock protein family A (Hsp70) member 4 Homo sapiens 63-68 14980739-8 2004 stimulated Fos expression in the ARC, ADP, and LA. Adenosine Diphosphate 38-41 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 11-14 33119719-6 2020 The simultaneous stimulation with collagen and CXCL12 induced the secretion of platelet-derived growth factor (PDGF)-AB and the release of soluble CD40 ligand (sCD40L) from human platelets in addition to their aggregation, despite the fact that the simultaneous stimulation with thrombin receptor-activating peptide (TRAP) or adenosine diphosphate (ADP), and CXCL12 had little effects on the platelet aggregation. Adenosine Diphosphate 349-352 C-X-C motif chemokine ligand 12 Homo sapiens 47-53 15262482-10 2004 Flow cytometry revealed that the expressions of CD11b and CD35 on neutrophils were increased by PRPr, but not by ATP and ADP. Adenosine Diphosphate 121-124 integrin subunit alpha M Homo sapiens 48-53 14576981-13 2003 Increased UCP-2 expression under these conditions could reduce the beta-cell ATP/ADP ratio and negatively regulate insulin secretion. Adenosine Diphosphate 81-84 uncoupling protein 2 Rattus norvegicus 10-15 14529283-4 2003 Consistent with the enzyme expressed in mammalian cells, this recombinant NTPDase6 efficiently hydrolyzes GDP, IDP, and UDP (specific activity of approximately 50000 micromol mg(-1) h(-1)), with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP. Adenosine Diphosphate 236-239 ectonucleoside triphosphate diphosphohydrolase 6 Homo sapiens 74-82 14517228-1 2003 Productive cis folding by the chaperonin GroEL is triggered by the binding of ATP but not ADP, along with cochaperonin GroES, to the same ring as non-native polypeptide, ejecting polypeptide into an encapsulated hydrophilic chamber. Adenosine Diphosphate 90-93 heat shock protein family D (Hsp60) member 1 Homo sapiens 41-46 14517228-7 2003 Surprisingly, when this structure was compared with that of the previously determined GroEL-GroES-ADP complex, no other differences were observed. Adenosine Diphosphate 98-101 heat shock protein family D (Hsp60) member 1 Homo sapiens 86-91 14554103-2 2003 In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration. Adenosine Diphosphate 21-24 Cd2 molecule Rattus norvegicus 119-122 14554103-2 2003 In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration. Adenosine Diphosphate 21-24 Cd2 molecule Rattus norvegicus 289-292 14554103-2 2003 In particular, EGTA, ADP, and cyclosporin A (potent mitochondrial permeability transition antagonists) affected mainly Cd2+-induced changes in resting state respiration, eliminating its stimulation in KCl medium, while dithiothreitol (DTT, a dithiol reductant) produced its effect both on Cd2+ activation of the basal respiration and Cd2+ depression of uncoupler-stimulated respiration, evoking its restoration. Adenosine Diphosphate 21-24 Cd2 molecule Rattus norvegicus 289-292 12893834-2 2003 The yeast ADP/ATP carrier (AAC3) was overexpressed, inhibited by atractyloside, purified, and reconstituted into two-dimensional crystals. Adenosine Diphosphate 10-13 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 27-31 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 122-143 integrin subunit alpha 2b Homo sapiens 22-27 12714504-7 2003 Further, anti-CIB- or GPIIb peptide-induced inhibition of platelet spreading can be overcome by the addition of exogenous adenosine diphosphate (ADP). Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 22-27 12714504-8 2003 These data suggest that formation of the CIB-GPIIb/IIIa complex may be necessary for initiation of downstream signaling events, such as ADP secretion, that lead to platelet spreading. Adenosine Diphosphate 136-139 integrin subunit alpha 2b Homo sapiens 45-50 12899702-7 2003 Taken together, these results indicate that NTPDase1 would terminate P2 receptor-mediated signal transmission whereas activity of NTPDase2 may contribute to decreasing high (toxic) concentrations of ATP and/or to production of another signal molecule, ADP. Adenosine Diphosphate 252-255 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 130-138 12911597-5 2003 GPIIb/IIIa blockade enhanced ADP- or TRAP-induced leukocyte CD11b expression, but not the response to PAF. Adenosine Diphosphate 29-32 integrin subunit alpha 2b Homo sapiens 0-5 12911597-5 2003 GPIIb/IIIa blockade enhanced ADP- or TRAP-induced leukocyte CD11b expression, but not the response to PAF. Adenosine Diphosphate 29-32 integrin subunit alpha M Homo sapiens 60-65 12911597-6 2003 GPIIb/IIIa blockade attenuated PAF-induced, but enhanced ADP- or TRAP-induced platelet-leukocyte aggregation. Adenosine Diphosphate 57-60 integrin subunit alpha 2b Homo sapiens 0-5 12911597-11 2003 GPIIb/IIIa blockade enhances thrombin-induced platelet MEK 1/2 and ERK 1/2 activation, and augments ADP- and TRAP-induced leukocyte activation by enhancing platelet-leukocyte aggregation. Adenosine Diphosphate 100-103 integrin subunit alpha 2b Homo sapiens 0-5 12911598-4 2003 Furthermore, TRA-418 inhibited not only platelet aggregation induced by ADP alone, but also that induced by ADP in the presence of the TP-receptor antagonist, SQ-29548. Adenosine Diphosphate 72-75 T cell receptor alpha locus Homo sapiens 13-16 12911598-4 2003 Furthermore, TRA-418 inhibited not only platelet aggregation induced by ADP alone, but also that induced by ADP in the presence of the TP-receptor antagonist, SQ-29548. Adenosine Diphosphate 108-111 T cell receptor alpha locus Homo sapiens 13-16 12911598-5 2003 When the IC50 values of TRA-418 for platelet aggregation were estimated in platelet preparations from monkeys, dogs, cats, and rats using ADP and arachidonic acid as the platelet stimulating agents, it was found that the values estimated in monkey platelets were quite similar to those estimated in human platelets. Adenosine Diphosphate 138-141 T cell receptor alpha locus Homo sapiens 24-27 12628750-1 2003 Poly(ADP-ribose) polymerases (PARPs) are a group of protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD to substrate proteins. Adenosine Diphosphate 5-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 30-35 12649347-6 2003 As discussed herein, CD39 rapidly and preferentially metabolizes ATP and ADP released from activated platelets to AMP, thereby drastically reducing or even abolishing platelet aggregation and recruitment. Adenosine Diphosphate 73-76 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 21-25 12649347-7 2003 Since ADP is the final common agonist for platelet recruitment and thrombus formation, this finding highlights the significance of CD39. Adenosine Diphosphate 6-9 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 131-135 12871418-7 2003 These results provide the direct evidence that, in human platelets, GPIbalpha and ADP act in synergy to amplify PAR1 coupled responses while PAR4 is activated independently of GPIbalpha and ADP. Adenosine Diphosphate 190-193 glycoprotein Ib platelet subunit alpha Homo sapiens 68-77 12456682-6 2003 Hsp70 has been found to regulate the affinity of PEX5 for a PTS1-containing protein, but we found that the kinetics of PEX5-PTS1 binding was unaffected by Hsp70, Hsp70 plus ATP, or Hsp70 plus ADP. Adenosine Diphosphate 192-195 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 12621388-5 2003 Up-regulation of MAC-1 on monocytes after stimulation with thrombin receptor-activating peptide and adenosine diphosphate was significantly lower in patients treated with clopidogrel and aspirin. Adenosine Diphosphate 100-121 integrin subunit alpha M Homo sapiens 17-22 12626998-10 2003 MEASUREMENTS AND MAIN RESULTS: Expression of GP IIb-IIIa and P-selectin on adenosine diphosphate-activated platelets and platelet-leukocyte aggregation were significantly lower after the passage of blood through the hemofilter in patients receiving an extracorporeal infusion of prostacyclin plus heparin when compared with control patients receiving heparin only. Adenosine Diphosphate 75-96 integrin subunit alpha 2b Homo sapiens 45-51 12604678-7 2003 MgADP or MgUDP (100 microM) augmented the inhibitory effect of nateglinide on SUR1/Kir6.2 but not SUR1(S1237Y)/Kir6.2 or SUR2A/Kir6.2 channels. Adenosine Diphosphate 0-5 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 83-89 12604678-8 2003 This augmenting effect of MgADP was also observed with the SUR1/Kir6.2(K185Q) channel, which was not inhibited by MgADP, but not with the SUR1(K1384A)/Kir6.2 channel, which was not activated by MgADP. Adenosine Diphosphate 26-31 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 64-70 12604678-8 2003 This augmenting effect of MgADP was also observed with the SUR1/Kir6.2(K185Q) channel, which was not inhibited by MgADP, but not with the SUR1(K1384A)/Kir6.2 channel, which was not activated by MgADP. Adenosine Diphosphate 26-31 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 151-157 12648570-5 2003 A single-ring GroEL/GroES variant complexed with one dPJ9 molecule was used to study the structural changes of dPJ9 in GroEL/GroES/dPJ9 complexes formed with ADP and with ATP. Adenosine Diphosphate 158-161 heat shock protein family D (Hsp60) member 1 Homo sapiens 14-19 12648570-5 2003 A single-ring GroEL/GroES variant complexed with one dPJ9 molecule was used to study the structural changes of dPJ9 in GroEL/GroES/dPJ9 complexes formed with ADP and with ATP. Adenosine Diphosphate 158-161 heat shock protein family D (Hsp60) member 1 Homo sapiens 119-124 12648570-6 2003 It was found that both the shape and the position of the bound dPJ9 in the GroEL/GroES/dPJ9 complex with ADP were the same as those in the GroEL/dPJ9 complex. Adenosine Diphosphate 105-108 heat shock protein family D (Hsp60) member 1 Homo sapiens 75-80 12648570-6 2003 It was found that both the shape and the position of the bound dPJ9 in the GroEL/GroES/dPJ9 complex with ADP were the same as those in the GroEL/dPJ9 complex. Adenosine Diphosphate 105-108 heat shock protein family D (Hsp60) member 1 Homo sapiens 139-144 12466270-10 2003 These results suggest that myosin VIIA has slow ATP binding or low affinity for ATP and relatively high affinity for ADP. Adenosine Diphosphate 117-120 myosin VIIA Homo sapiens 27-38 12693968-3 2003 Suppression of GP IIb-IIIa receptor activity by both preparations led to 100% inhibition of [(14)C]serotonin secretion from dense granules upon platelet activation with ADP, to partial inhibition upon activation with thromboxane A(2) analog U46619 (by 60-70%) and thrombin at 0.1 U/ml (by 40-50%), but did not decrease serotonin secretion induced by thrombin at 1 U/ml. Adenosine Diphosphate 169-172 integrin subunit alpha 2b Homo sapiens 15-21 12632022-5 2003 Co-incubation of whole blood samples with TRAP, ADP together with 3,5-DIPS, or Ca(II)3 (3,5-DIPS)6 revealed that Ca(II)3 (3,5-DIPS)6 caused a decrease in platelet P-selectin expression for TRAP, ADP, and no-activator co-incubated samples of whole blood. Adenosine Diphosphate 195-198 TRAP Homo sapiens 42-46 12480534-2 2003 The addition of GAPN-which oxidizes glyceraldehyde-3-phosphate directly to the 3-phosphoglyceric acid-led to the strong increase in the rate of lactate accumulation in the rat muscle extract with low ADP content. Adenosine Diphosphate 200-203 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 16-20 12480534-3 2003 The lactate accumulation was also observed in the presence of GAPN in rat muscle extract, which contained only ATP and no ADP. Adenosine Diphosphate 122-125 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 62-66 14640903-1 2003 Enzymes that hydrolyze extracellular ATP, i.e. ecto-ATPase and ecto-ATP diphosphohydrolase (ATPDase), can be differentiated by ability of the latter to hydrolyze ADP and by slightly different kinetic properties of the two enzymes. Adenosine Diphosphate 162-165 CEA cell adhesion molecule 1 Rattus norvegicus 47-58 12390247-0 2002 ADP stabilizes the human Rad51-single stranded DNA complex and promotes its DNA annealing activity. Adenosine Diphosphate 0-3 RAD51 recombinase Homo sapiens 25-30 12390247-5 2002 While ADP lowers the affinity of RecA protein to ssDNA, it is found to rather stabilize the HsRad51-ssDNA complex. Adenosine Diphosphate 6-9 RAD51 recombinase Homo sapiens 33-37 12390247-5 2002 While ADP lowers the affinity of RecA protein to ssDNA, it is found to rather stabilize the HsRad51-ssDNA complex. Adenosine Diphosphate 6-9 RAD51 recombinase Homo sapiens 92-99 12161444-5 2002 This is accomplished by stimulating the conversion of hsp70-ATP to hsp70-ADP, the hsp70 conformation favored for Hop binding. Adenosine Diphosphate 73-76 heat shock protein family A (Hsp70) member 4 Homo sapiens 54-59 12161444-5 2002 This is accomplished by stimulating the conversion of hsp70-ATP to hsp70-ADP, the hsp70 conformation favored for Hop binding. Adenosine Diphosphate 73-76 heat shock protein family A (Hsp70) member 4 Homo sapiens 67-72 12161444-5 2002 This is accomplished by stimulating the conversion of hsp70-ATP to hsp70-ADP, the hsp70 conformation favored for Hop binding. Adenosine Diphosphate 73-76 heat shock protein family A (Hsp70) member 4 Homo sapiens 67-72 12138093-5 2002 Importantly, the reconstituted TIM10 complex is functional because it bound to the physiological substrate ADP/ATP carrier and displayed chaperone activity in refolding the model substrate firefly luciferase. Adenosine Diphosphate 107-110 translocase of inner mitochondrial membrane 10 Homo sapiens 31-36 12196468-7 2002 In islets exposed to high FFA concentration, a PPAR-gamma antagonist was able to prevent UCP-2 overexpression and to restore insulin secretion and the ATP/ADP ratio. Adenosine Diphosphate 155-158 peroxisome proliferator-activated receptor gamma Rattus norvegicus 47-57 12036965-1 2002 Guanylate kinase (GMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryl transfer from ATP to GMP to yield ADP and GDP. Adenosine Diphosphate 136-139 guanylate kinase 1 Mus musculus 0-16 12145099-9 2002 6: The data show (a) that the inhibitory effects of ATP and ADP on glibenclamide binding differ from one another, (b) that they depend on the SUR subtype, and (c) that they are weakened by coexpression with Kir6.2. Adenosine Diphosphate 60-63 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 207-213 12135363-6 2002 In the absence of S3, Lon exhibits a 10-20-fold higher affinity for ADP than ATP. Adenosine Diphosphate 68-71 putative ATP-dependent Lon protease Escherichia coli 22-25 12135363-7 2002 However the S3 substrate weakens the affinity of Lon for ADP by 7-19-fold, indicating that this peptide also promotes ADP/ATP exchange in Lon similar to that observed with protein substrates. Adenosine Diphosphate 57-60 putative ATP-dependent Lon protease Escherichia coli 49-52 12135363-7 2002 However the S3 substrate weakens the affinity of Lon for ADP by 7-19-fold, indicating that this peptide also promotes ADP/ATP exchange in Lon similar to that observed with protein substrates. Adenosine Diphosphate 118-121 putative ATP-dependent Lon protease Escherichia coli 49-52 12413588-4 2002 Platelet function was measured by the PFA-100(R) analyser; platelet GP IIb-IIIa activation by ADP 10 micro M was assessed by flow cytometry using PAC-1 MoAb. Adenosine Diphosphate 94-97 integrin subunit alpha 2b Homo sapiens 68-74 12088455-7 2002 RESULTS: After C1-INH infusion, we observed a prompt increase of C1-INH level and a slow return toward its plasma preinfusion values within 4 to 7 days, a significant decrease of both adenosine diphosphate- and collagen-induced platelet aggregation versus preinfusion values (maximum after 1-2 days; P <.001), and a rapid decrease of high basal values of XIIa and F1.2 in 30 and 120 minutes, respectively. Adenosine Diphosphate 184-205 serpin family G member 1 Homo sapiens 15-21 12086984-10 2002 In inside-out patches from HEK 293 cells expressing the cloned K(ATP) channel subunits Kir6.2/SUR2A, increasing the concentration of ADP (1 - 100 microM), in the presence of 100 nM glimepiride, lead to significant increases in Kir6.2/SUR2A channel activity. Adenosine Diphosphate 133-136 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 87-93 12057768-7 2002 Treatment of the cells with ADP, C5a and H(2)O(2) (100 microM) all increased the phosphorylation of c-Jun. Adenosine Diphosphate 28-31 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 100-105 23345759-4 2002 Similarly, the bindingconstant between GroEL and the folding intermediate decreased in acooperative manner with an increase in ATP concentration although itshowed non-cooperative decrease with respect to ADP concentration. Adenosine Diphosphate 204-207 heat shock protein family D (Hsp60) member 1 Homo sapiens 39-44 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 166-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 42-47 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 166-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 166-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 166-169 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 392-395 heat shock protein family D (Hsp60) member 1 Homo sapiens 42-47 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 392-395 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 392-395 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 23345759-5 2002 Itis shown that the allosteric control of GroEL by the nucleotides isresponsible for the above behavior of GroEL and that the observeddifference between the ATP- and ADP-induced transitions of GroEL isbrought about by a small difference in an allosteric parameter (the ratio ofthe nucleotide affinities of GroEL in the high-affinity and the low-affinitystates), i.e., 4.1 for ATP and 2.6 for ADP. Adenosine Diphosphate 392-395 heat shock protein family D (Hsp60) member 1 Homo sapiens 107-112 11916875-1 2002 Nucleotide binding to RecA results in either the high-DNA affinity form (Adenosine 5"-triphosphate (ATP)-bound) or the more inactive protein conformation associated with a lower affinity for DNA (Adenosine 5"-diphosphate (ADP)-bound). Adenosine Diphosphate 196-220 RAD51 recombinase Homo sapiens 22-26 11916875-1 2002 Nucleotide binding to RecA results in either the high-DNA affinity form (Adenosine 5"-triphosphate (ATP)-bound) or the more inactive protein conformation associated with a lower affinity for DNA (Adenosine 5"-diphosphate (ADP)-bound). Adenosine Diphosphate 222-225 RAD51 recombinase Homo sapiens 22-26 11916875-4 2002 The photochemical release of nucleotides (ADP and ATP) from biologically inactive precursors was used to initiate nucleotide binding to RecA. Adenosine Diphosphate 42-45 RAD51 recombinase Homo sapiens 136-140 11895777-8 2002 Specifically, Lyn is required under these conditions to enable thrombin-induced TxA2 production and adenosine diphosphate secretion, necessary steps in secretion-dependent platelet aggregation. Adenosine Diphosphate 100-121 LYN proto-oncogene, Src family tyrosine kinase Mus musculus 14-17 11904526-7 2002 ADP-induced platelet degranulation, activation of GPIIb/IIIa receptor, and aggregation in vivo are effectively inhibited by clopidogrel. Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 50-55 11956240-1 2002 Endothelial CD39 metabolizes ADP released from activated platelets. Adenosine Diphosphate 29-32 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-16 11927941-1 2002 CD39, the endothelial ecto-nucleoside triphosphate diphosphohydrolase (NTPDase), regulates vascular inflammation and thrombosis by hydrolyzing ATP and ADP. Adenosine Diphosphate 151-154 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 11911844-6 2002 The ADP-ribosylation of PARP was assessed by Western blot analysis and then quantified. Adenosine Diphosphate 4-7 poly (ADP-ribose) polymerase family, member 1 Mus musculus 24-28 11867522-0 2002 The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier. Adenosine Diphosphate 67-70 translocase of inner mitochondrial membrane 10 Homo sapiens 10-16 11867522-6 2002 The Tim9p-Tim10p complex bound specifically to the transmembrane domains of the ADP/ATP carrier, but had no affinity for Tim23p, an inner membrane protein that is inserted via the TIM22 complex. Adenosine Diphosphate 80-83 translocase of inner mitochondrial membrane 10 Homo sapiens 10-16 12031829-8 2002 The results revealed that besides the inhibition of cyclooxygenase pathway and receptors for adenosine diphosphate (ADP) and glycoproteins Gp IIbIIIa, the interaction of drugs with cPLA2 may represent a further site for antiplatelet action. Adenosine Diphosphate 93-114 phospholipase A2 group IVA Homo sapiens 181-186 12031829-8 2002 The results revealed that besides the inhibition of cyclooxygenase pathway and receptors for adenosine diphosphate (ADP) and glycoproteins Gp IIbIIIa, the interaction of drugs with cPLA2 may represent a further site for antiplatelet action. Adenosine Diphosphate 116-119 phospholipase A2 group IVA Homo sapiens 181-186 11779463-3 2001 These observations, together with the effects of ATP binding to a GroEL-GroES-ADP complex, suggest structural models for the ATP-induced reduction in affinity for polypeptide and for cooperativity. Adenosine Diphosphate 78-81 heat shock protein family D (Hsp60) member 1 Homo sapiens 66-71 11606590-6 2001 Interestingly, US6 causes a specific arrest of the peptide-stimulated ATPase activity of TAP by preventing binding of ATP but not ADP. Adenosine Diphosphate 130-133 membrane glycoprotein US6 Human betaherpesvirus 5 15-18 11874248-7 2001 From analogy to E. coli ATP-dependent protease La (LON), we suggest that the activator peptides stimulated the proteolysis by releasing enzyme-bound ADP. Adenosine Diphosphate 149-152 putative ATP-dependent Lon protease Escherichia coli 51-54 11511517-0 2001 Overexpression of UCP3 in cultured human muscle lowers mitochondrial membrane potential, raises ATP/ADP ratio, and favors fatty acid vs. glucose oxidation. Adenosine Diphosphate 100-103 uncoupling protein 3 Homo sapiens 18-22 11439109-3 2001 At variance with serine-autophosphorylation, tyrosine-autophosphorylation of CK2alpha is reversed by ADP and GDP and is counteracted by the beta-subunit and by a peptide reproducing the activation loop of CK2alpha/alpha" (amino acids 175-201). Adenosine Diphosphate 101-104 casein kinase 2 alpha 2 Homo sapiens 77-85 11508269-10 2001 Evidence suggested that CD38 on B lymphocytes competes with ART2.2 for substrate needed by B lymphocytes for ADP ribosylation. Adenosine Diphosphate 109-112 CD38 antigen Mus musculus 24-28 11479373-7 2001 Recombinant AtIPT4 catalyzed the transfer of an isopentenyl group from dimethylallyl diphosphate to the N(6) of ATP and ADP, but not to that of AMP. Adenosine Diphosphate 120-123 isopentenyltransferase 4 Arabidopsis thaliana 12-18 32803122-7 2020 Results In contrast to room temperature, ADP-induced aggregation was maintained under cold storage for 6 days, associated with elevated activation markers like fibrinogen binding or CD62P expression. Adenosine Diphosphate 42-45 selectin P Homo sapiens 183-188 32404037-14 2020 In vitro, the incubation of human and rat platelet-rich plasma with ApoA1-M significantly reduced ADP-induced platelet aggregation (P=0.001 and P=0.02, respectively). Adenosine Diphosphate 98-101 apolipoprotein A1 Rattus norvegicus 68-73 32486261-8 2020 In addition, platelet aggregation in response to the second challenge of ADP and AYPGKF was restored in GRK6-/- platelets whereas re-stimulation of the agonist failed to induce aggregation in WT platelets, indicating that GRK6 contributed to P2Y1, P2Y12, and PAR4 receptor desensitization. Adenosine Diphosphate 73-76 G protein-coupled receptor kinase 6 Mus musculus 104-108 32065636-2 2020 We previously characterized the Arabidopsis thaliana gene (At1g25380), named AtNDT2, encoding a protein located in the mitochondrial inner membrane, which imports NAD+ from the cytosol using ADP and AMP as counter-exchange substrates for NAD+. Adenosine Diphosphate 191-194 NAD+ transporter 2 Arabidopsis thaliana 77-83 32365642-7 2020 The function of microglia is regulated by a whole array of purinergic receptors classified as P2Y12, P2Y6, P2Y4, P2X4, P2X7, A2A, and A3, as targets of endogenous ATP, ADP, or adenosine. Adenosine Diphosphate 168-171 pyrimidinergic receptor P2Y6 Homo sapiens 101-105 32344771-10 2020 S-glutathionylation is mainly known to be responsible for protein loss of function, and molecular dynamics simulations and 3D structure predictions confirmed such deleterious impacts on adenine nucleotide translocator 2 (ANT2), by weakening its affinity to ATP/ADP. Adenosine Diphosphate 261-264 solute carrier family 25 member 6 Homo sapiens 186-219 32344771-10 2020 S-glutathionylation is mainly known to be responsible for protein loss of function, and molecular dynamics simulations and 3D structure predictions confirmed such deleterious impacts on adenine nucleotide translocator 2 (ANT2), by weakening its affinity to ATP/ADP. Adenosine Diphosphate 261-264 solute carrier family 25 member 6 Homo sapiens 221-225 32217379-8 2020 Moreover, Anthocyanin supplements decreased ADP-induced platelet activation configuration expressed as P-selectin by 40% (P < .05). Adenosine Diphosphate 44-47 selectin P Homo sapiens 103-113 32231086-8 2020 Using FurNAD-RNAs, we discovered that the eukaryotic glycohydrolase CD38 processes NAD-capped RNA in vitro into ADP-ribose-modified-RNA and nicotinamide and therefore might act as a decapping enzyme in vivo. Adenosine Diphosphate 112-115 CD38 molecule Homo sapiens 68-72 32049380-9 2020 Both urinary ATP and its hydrolysis product, ADP, an agonist to P2Y6, were positively correlated with total OAB symptom score (P = .010 and P = .042, respectively). Adenosine Diphosphate 45-48 pyrimidinergic receptor P2Y6 Homo sapiens 64-68 11279243-1 2001 ADP-ribosylation factor 1 (ARF1) was originally found as a cofactor in CT-catalyzed ADP-ribosylation of Galpha(s) but is now known to participate in vesicle trafficking. Adenosine Diphosphate 0-3 ADP-ribosylation factor 1 Cricetulus griseus 27-31 32058968-2 2020 Both the conformational events tuned by ATP/ADP and co-chaperones and the chaperoning cycle timing are required for Hsp90"s fully functional display. Adenosine Diphosphate 44-47 heat shock protein 90 alpha family class A member 1 Homo sapiens 116-121 32049026-2 2020 Among the multitude of gephyrin-binding proteins is IQSEC3, a recently identified component at GABAergic synapses that acts through its ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF) activity to orchestrate GABAergic synapse formation. Adenosine Diphosphate 136-139 IQ motif and Sec7 domain 3 Mus musculus 52-58 11278618-5 2001 Although nucleotides are not absolutely required for DNA binding, ADP stimulated the binding of UL5-UL52 to single strand DNA whereas ATP, ADP, and adenosine 5"-O-(thiotriphosphate) stimulated the binding to a forked substrate. Adenosine Diphosphate 66-69 helicase-primase helicase subunit Human alphaherpesvirus 1 96-99 31520551-2 2020 While P2Y12 receptors are known to play a key role in targeting directed motility of microglial processes to sites of damage where ATP/ADP is released, little is known about the role of P2Y13 , which transcriptome data suggest is the second most expressed neurotransmitter receptor in microglia. Adenosine Diphosphate 135-138 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 6-11 31520551-3 2020 We show that, in patch-clamp recordings in acute brain slices from mice lacking P2Y13 receptors, the THIK-1 K+ current density evoked by ADP activating P2Y12 receptors was increased by ~50%. Adenosine Diphosphate 137-140 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 80-85 11323013-4 2001 RESULTS: For citrated blood, aggregation induced by 20 microM ADP was blocked up to 100% by both GPIIb/IIIa-antagonists, IC50 values varied between 0.11-0.22 microg/ml for eptifibatide and 1.25-2.3 microg/ml for abciximab. Adenosine Diphosphate 62-65 integrin subunit alpha 2b Homo sapiens 97-102 31520551-3 2020 We show that, in patch-clamp recordings in acute brain slices from mice lacking P2Y13 receptors, the THIK-1 K+ current density evoked by ADP activating P2Y12 receptors was increased by ~50%. Adenosine Diphosphate 137-140 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 152-157 31520551-4 2020 This increase suggested that the P2Y12 -dependent chemotaxis response should be potentiated; however, the time needed for P2Y12 -mediated convergence of microglial processes onto an ADP-filled pipette or to a laser ablation was longer in the P2Y13 KO. Adenosine Diphosphate 182-185 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 122-127 11239710-0 2001 Adhesion of adenosine diphosphate-activated platelets to human brain microvascular endothelial cells under flow in vitro is mediated via GPIIb/IIIa. Adenosine Diphosphate 12-33 integrin subunit alpha 2b Homo sapiens 137-142 11085994-10 2001 The presence of either ATP or ADP but not AMP-PNP leads to GroEL dissociation at lower pressures. Adenosine Diphosphate 30-33 heat shock protein family D (Hsp60) member 1 Homo sapiens 59-64 31204292-9 2020 Using platelet-rich-plasma, antagonists of P2Y1 or P2Y12 receptors for ADP reduced both the retention and aggregation of PLTs. Adenosine Diphosphate 71-74 purinergic receptor P2Y1 Homo sapiens 43-47 11342206-6 2001 All tested GPIIb-IIIa antagonists completely inhibit concentration-dependent ADP (20 micromol/l)-induced aggregation. Adenosine Diphosphate 77-80 integrin subunit alpha 2b Homo sapiens 11-16 11122160-6 2000 Activation of GPIIb-IIIa, monitored with mAb PAC-1, was markedly decreased (< 20% of normal) in response to ADP, thrombin and platelet-activating factor (PAF); expression of ligand-induced binding sites (LIBS) was < or = 30% of normal. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 14-19 31862713-0 2020 Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques. Adenosine Diphosphate 20-23 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 57-62 31862713-5 2020 However, there is no consensus regarding the conformation of the ADP-bound Hsp90, which is considered important for client release. Adenosine Diphosphate 65-68 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 75-80 11073882-5 2000 In inside-out patches of human embryonic kidney 293T cells coexpressing distinct SURs and Kir6.2, much higher concentrations of ADP were needed to activate channels that contained SUR2A than SUR1 or SUR2B. Adenosine Diphosphate 128-131 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 90-96 11465076-5 2000 CD39, the ATP diphosphohydrolase (ATPDase) expressed on quiescent vascular endothelium, modulates platelet purinoreceptor activity by the sequential hydrolysis of extracellular ATP or ADP directly to AMP. Adenosine Diphosphate 184-187 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 31738933-9 2020 In the presence of ticagrelor, blockage of the P2Y1 receptor prevented restoration of platelet aggregation by the combination of epinephrine and ADP, as well as intracellular Ca2+ mobilisation. Adenosine Diphosphate 145-148 purinergic receptor P2Y1 Homo sapiens 47-60 31738933-10 2020 In combination with ADP, epinephrine induced platelet aggregation of ticagrelor-treated platelets through inhibition of the cAMP pathway and activation of the PI3K pathway, thus enabling the P2Y1 receptor signalling and subsequent Ca2+ mobilisation. Adenosine Diphosphate 20-23 purinergic receptor P2Y1 Homo sapiens 191-204 11032875-8 2000 In contrast, GLUD2 GDH activated by ADP and/or L-leucine was amenable to this inhibition, although at substantially higher GTP concentrations than the GLUD1 enzyme. Adenosine Diphosphate 36-39 glutamate dehydrogenase 2 Homo sapiens 13-18 10899168-0 2000 ATP and ADP modulate a cation channel formed by Hsc70 in acidic phospholipid membranes. Adenosine Diphosphate 8-11 heat shock protein family A (Hsp70) member 8 Homo sapiens 48-53 31869665-8 2020 IIIM-1266 and IIIM-1270 displayed bidentate H-bonding with Arg 346 and Glu 305 residues in the active site of ER-beta; and they also strongly occupied the ADP-binding site of NLRP3 protein. Adenosine Diphosphate 155-158 NLR family, pyrin domain containing 3 Mus musculus 175-180 33146056-3 2020 CD39 processes pro-inflammatory extracellular ATP to ADP and AMP, which is then processed by Ecto-5"-nucleotidase/CD73 to immunosuppressive adenosine. Adenosine Diphosphate 53-56 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 30810440-3 2020 Thrombin activates platelets via the protease-activated receptors (PARs) 1 and 4, whereas ADP signals via the receptors P2Y1 and P2Y12 as a positive feedback mediator of platelet activation. Adenosine Diphosphate 90-93 purinergic receptor P2Y1 Homo sapiens 120-124 10899168-6 2000 The Hsc70 channel activity is ATP-dependent and is reversibly blocked by ADP. Adenosine Diphosphate 73-76 heat shock protein family A (Hsp70) member 8 Homo sapiens 4-9 30810440-7 2020 Interestingly, we observed enhanced P2Y1/P2Y12-mediated dense granule trafficking in neonatal platelets relative to adults, although P2Y1/P2Y12 expression in neonatal, cord, and adult platelets were similar, suggesting that neonatal platelets may employ an ADP-mediated positive feedback loop as a potential compensatory mechanism for neonatal platelet hyporeactivity. Adenosine Diphosphate 257-260 purinergic receptor P2Y1 Homo sapiens 36-40 31116063-8 2020 Furthermore, platelets secreted DEFA1 into the culture medium when activated with thrombin, adenosine diphosphate, and lipopolysaccharide; meanwhile, MEG-01 cells secreted DEFA1 when activated with thrombopoietin. Adenosine Diphosphate 92-113 defensin alpha 1 Homo sapiens 32-37 31892271-0 2019 Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3. Adenosine Diphosphate 64-67 poly(ADP-ribose) polymerase family member 3 Homo sapiens 148-154 31493483-7 2019 In addition, EPO-SLN reduced the oxidative stress, ADP/ATP ratio, and beta-amyloid plaque deposition in the hippocampus more effectively than the free EPO. Adenosine Diphosphate 51-54 erythropoietin Rattus norvegicus 13-16 11001901-6 2000 ADP addition to platelets caused an increase in the number of D3 binding sites indicating that ligand had bound to the GPIIb-IIIa receptor. Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 119-124 31493483-7 2019 In addition, EPO-SLN reduced the oxidative stress, ADP/ATP ratio, and beta-amyloid plaque deposition in the hippocampus more effectively than the free EPO. Adenosine Diphosphate 51-54 sarcolipin Rattus norvegicus 17-20 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 63-84 integrin subunit alpha M Homo sapiens 156-161 10997789-4 2000 We find that binding of fibrinogen on monocytes activated with adenosine diphosphate (ADP) was reduced to 66.0+/-8.3% (mean +/- SD) in the presence of anti-CD11b antibodies (12.5 microg/ml; P < or = 0.02) and to 54.5+/-4.9% in the presence of anti-CD18 antibodies (20 microg/ml; P < or = 0.01), respectively. Adenosine Diphosphate 86-89 integrin subunit alpha M Homo sapiens 156-161 31610054-0 2019 Allosteric Discrimination at the NADH/ADP Regulatory Site of Glutamate Dehydrogenase. Adenosine Diphosphate 38-41 glutamate dehydrogenase 1 Homo sapiens 61-84 10997789-9 2000 Neither incubation with HDL3 or with LDL had a significant influence on ADP-activated cellular binding of anti-CD11b or anti-CD18 antibodies. Adenosine Diphosphate 72-75 integrin subunit alpha M Homo sapiens 111-116 31610054-3 2019 Our computational investigation of the NADH/ADP site presented in this paper provides insight into the opposite allosteric effects induced at a single site of binding inhibitor NADH versus activator ADP to GDH. Adenosine Diphosphate 44-47 glutamate dehydrogenase 1 Homo sapiens 206-209 10945241-2 2000 The canalicular membrane enzyme Ca2+/Mg2+-ecto-ATPase (ecto-ATPase) hydrolyzes ATP/adenosine diphosphate (ATP/ADP) and regulates hepatic extracellular ATP concentration. Adenosine Diphosphate 110-113 CEA cell adhesion molecule 1 Rattus norvegicus 32-53 31610054-3 2019 Our computational investigation of the NADH/ADP site presented in this paper provides insight into the opposite allosteric effects induced at a single site of binding inhibitor NADH versus activator ADP to GDH. Adenosine Diphosphate 199-202 glutamate dehydrogenase 1 Homo sapiens 206-209 31610054-5 2019 Our simulations show an interesting model of ADP with dissimilar binding conformations at each NADH/ADP site in the GDH trimer, which explains the poorly understood strong binding but weak activation shown in experimental studies. Adenosine Diphosphate 45-48 glutamate dehydrogenase 1 Homo sapiens 116-119 31610054-5 2019 Our simulations show an interesting model of ADP with dissimilar binding conformations at each NADH/ADP site in the GDH trimer, which explains the poorly understood strong binding but weak activation shown in experimental studies. Adenosine Diphosphate 100-103 glutamate dehydrogenase 1 Homo sapiens 116-119 31815035-2 2019 PGK1 catalyzes the reversible transfer of a phosphate group from 1,3-bisphosphoglycerate to ADP and produces 3-phosphoglycerate and ATP. Adenosine Diphosphate 92-95 phosphoglycerate kinase 1 Homo sapiens 0-4 31400387-2 2019 The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 1 Homo sapiens 106-111 31400387-2 2019 The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 1 Homo sapiens 113-118 31618756-5 2019 Whereas pharmacological inhibition of ANT-mediated ADP/ATP exchange promotes mitophagy, genetic ablation of ANT paradoxically suppresses mitophagy. Adenosine Diphosphate 51-54 solute carrier family 25 member 6 Homo sapiens 38-41 31727786-3 2019 Here, we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean (Glycine max) within two highly conserved nitrate-induced (NOI) domains. Adenosine Diphosphate 35-38 RPM1 interacting protein 4 Arabidopsis thaliana 55-59 31727786-5 2019 The ADP-ribosylation activity of AvrRpm1 is required for subsequent phosphorylation on Thr-166 of AtRIN4, an event that is necessary and sufficient for RPM1 activation. Adenosine Diphosphate 4-7 RPM1 interacting protein 4 Arabidopsis thaliana 98-104 31469273-5 2019 We have also determined the crystal structure of B. cenocepacia HMGR in the hexameric state bound to coenzyme A and ADP. Adenosine Diphosphate 116-119 high mobility group AT-hook 1 Homo sapiens 64-68 31125567-9 2019 Moreover, J-protein promotes the Hsp70-Hsp90 interaction in the presence of ATP, likely by converting Hsp70 into the ADP-bound conformation. Adenosine Diphosphate 117-120 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 39-44 30929196-7 2019 Both ADP-induced platelet aggregation (n=116, r2=-0.5042, P<0.001) and vWF activity (n=116, r2=-0.2872, P<0.001) were negatively correlated with beta2-GPI levels. Adenosine Diphosphate 5-8 apolipoprotein H Homo sapiens 151-160 31222087-6 2019 DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death. Adenosine Diphosphate 129-132 eukaryotic translation elongation factor 2 Homo sapiens 52-94 31222087-6 2019 DTA exerts its toxic activity through inhibition of eukaryotic translation elongation factor 2 (eEF2) via adenosine diphosphate (ADP)-ribosylation of a modified histidine residue, diphthamide, at His715, which blocks protein translation and leads to cell death. Adenosine Diphosphate 129-132 eukaryotic translation elongation factor 2 Homo sapiens 96-100 30797004-5 2019 Accordingly, the goal of this work was to evaluate the interaction of either ADP or ATP with recombinant Hsp90s from different organisms (human alpha and beta isoforms, Plasmodium falciparum, Leishmania braziliensis, yeast and sugarcane) by isothermal titration calorimetry. Adenosine Diphosphate 77-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 105-110 30797004-9 2019 Altogether, the data suggest that selective inhibition may be more easily achieved using analogues of the Hsp90-ADP bound state than those of Hsp90-ATP bound state. Adenosine Diphosphate 112-115 heat shock protein 90 alpha family class A member 1 Homo sapiens 106-111 30784176-10 2019 Platelet function was compared between patients with and without TIC, defined by prothrombin time >=18 s. Results Platelets in TIC showed no initial increase in their level of surface activation markers or impairment of their capacity to express CD62P in response to ADP stimulation. Adenosine Diphosphate 267-270 selectin P Homo sapiens 246-251 30336122-2 2019 CD39 inhibits T-cell and Natural killer (NK) cell responses by hydrolyzing adenosine triphosphate and adenosine diphosphate, suppressing the immune system. Adenosine Diphosphate 102-123 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 30664656-6 2019 HCC cells were found to be in late apoptotic stage on treatment with higher doses of ADP extract as depicted by acridine orange/ethidium bromide and Annexin V-FITC/PI double stain. Adenosine Diphosphate 85-88 annexin A5 Homo sapiens 149-158 29671861-7 2019 RESULTS: ADP-induced aggregation (57 +- 13 area under curve {AUC] units) was inhibited 73% by the P2Y1 antagonist, 86% by the P2Y12 antagonist, and 95% when combined (p < 0.001 for all). Adenosine Diphosphate 9-12 purinergic receptor P2Y1 Homo sapiens 98-102 30734681-3 2019 Recently, the important role in the platelet aggregation of adenosine diphosphate (ADP)-activated P2Y12 and P2Y1 receptors, Gprotein coupled receptors of the P2 purinergic family, has emerged, and their inhibitors are explored as potential therapeutic antithrombotics. Adenosine Diphosphate 83-86 purinergic receptor P2Y1 Homo sapiens 98-102 30052109-9 2019 The expression of platelet glycoproteins, such as GP IIb/IIIa and P-selectin, native or after stimulation with ADP, were markedly impaired by the conventional system, but not by the TCSS. Adenosine Diphosphate 111-114 selectin P Homo sapiens 66-76 29185836-7 2019 The gene-based meta-analysis identified a significant association (P = 7.13 x 10-7) between rare genetic variants in ANKRD26 and ADP-induced platelet aggregation. Adenosine Diphosphate 129-132 ankyrin repeat domain containing 26 Homo sapiens 117-124 30422037-6 2019 Platelet P-selectin expression was significantly enhanced at one month when stimulated by thrombin and U46619 and at three months with ADP and thrombin. Adenosine Diphosphate 135-138 selectin P Homo sapiens 9-19 30303204-1 2018 Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5"-nucleotidase (CD73) to immunosuppressive adenosine. Adenosine Diphosphate 134-137 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-48 30303204-1 2018 Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5"-nucleotidase (CD73) to immunosuppressive adenosine. Adenosine Diphosphate 134-137 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 50-58 30303204-1 2018 Ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) is a major ectonucleotidase that hydrolyzes proinflammatory ATP via ADP to AMP, which is subsequently converted by ecto-5"-nucleotidase (CD73) to immunosuppressive adenosine. Adenosine Diphosphate 134-137 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 60-64 30357593-5 2018 Once internalised, PE38 catalyses the ADP ribosylation of the diphthamide residue in elongation factor-2 (EF-2), resulting in the rapid fall in levels of the anti-apoptotic protein myeloid cell leukaemia 1 (Mcl-1), leading to apoptotic cell death. Adenosine Diphosphate 38-41 eukaryotic translation elongation factor 2 Homo sapiens 106-110 30357593-5 2018 Once internalised, PE38 catalyses the ADP ribosylation of the diphthamide residue in elongation factor-2 (EF-2), resulting in the rapid fall in levels of the anti-apoptotic protein myeloid cell leukaemia 1 (Mcl-1), leading to apoptotic cell death. Adenosine Diphosphate 38-41 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 181-205 29482349-6 2018 Patients with low HDL-C (<=35 mg/dL) exhibited a significantly higher P-selectin expression in response to ADP and higher platelet aggregation by the VerifyNow P2Y12 assay and the Impact-R than patients with normal HDL-C (>35 mg/dL; all P < .05). Adenosine Diphosphate 110-113 selectin P Homo sapiens 73-83 10945241-2 2000 The canalicular membrane enzyme Ca2+/Mg2+-ecto-ATPase (ecto-ATPase) hydrolyzes ATP/adenosine diphosphate (ATP/ADP) and regulates hepatic extracellular ATP concentration. Adenosine Diphosphate 110-113 CEA cell adhesion molecule 1 Rattus norvegicus 42-53 11004568-4 2000 During these studies, PDC was shown to be directly inhibited by a novel mechanism; the addition of supplemental recombinant PDKs, an effect that is ADP-dependent and partly alleviated by members of each of the compound classes tested. Adenosine Diphosphate 148-151 pyruvate dehydrogenase kinase 1 Homo sapiens 124-128 30397881-5 2018 Taken together, the results of the studies on ADP-ribosylation of DNA and the data obtained in this study suggest that PARP3 may be a component of the DNA break repair system involving the BER enzyme complex. Adenosine Diphosphate 46-49 poly(ADP-ribose) polymerase family member 3 Homo sapiens 119-124 10816501-4 2000 The Ib protomer (Ibp) bound to the cell surface, but trypsinization of Ibp was necessary for docking of the ADP-ribosylating component, iota a (Ia). Adenosine Diphosphate 108-111 ibp Clostridium perfringens 71-74 29648519-3 2018 GDH-1 activity is strongly inhibited by GTP, to near zero in the absence of ADP, and cooperatively activated ( n = 2.3) by ADP. Adenosine Diphosphate 76-79 glutamate dehydrogenase 1 Homo sapiens 0-5 29648519-3 2018 GDH-1 activity is strongly inhibited by GTP, to near zero in the absence of ADP, and cooperatively activated ( n = 2.3) by ADP. Adenosine Diphosphate 123-126 glutamate dehydrogenase 1 Homo sapiens 0-5 29648519-4 2018 The dissociation constant for ADP is near 200 microM in vivo, but leucine and its nonmetabolized analog 2-amino-2-norbornane-carboxylic acid (BCH) can activate GDH-1 by increasing the affinity for ADP. Adenosine Diphosphate 30-33 glutamate dehydrogenase 1 Homo sapiens 160-165 10859592-13 2000 The ATP-binding sites of IP(3)R1 bound much better ATP than ADP, AMP and particularly GTP, while IP(3)R3 displayed a much broader nucleotide specificity. Adenosine Diphosphate 60-63 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 25-32 29648519-4 2018 The dissociation constant for ADP is near 200 microM in vivo, but leucine and its nonmetabolized analog 2-amino-2-norbornane-carboxylic acid (BCH) can activate GDH-1 by increasing the affinity for ADP. Adenosine Diphosphate 197-200 glutamate dehydrogenase 1 Homo sapiens 160-165 29648519-5 2018 Under physiological conditions, as [ADP] increases GDH-1 activity remains very low until ~35 microM (threshold) and then increases rapidly. Adenosine Diphosphate 36-39 glutamate dehydrogenase 1 Homo sapiens 51-56 29648519-8 2018 As glucose falls < 5 mM the [ADP]-dependent increase in GDH-1 activity prevents [ADP] from rising above ~70 microM. Adenosine Diphosphate 32-35 glutamate dehydrogenase 1 Homo sapiens 59-64 29648519-8 2018 As glucose falls < 5 mM the [ADP]-dependent increase in GDH-1 activity prevents [ADP] from rising above ~70 microM. Adenosine Diphosphate 84-87 glutamate dehydrogenase 1 Homo sapiens 59-64 29648519-10 2018 GDH-1 hyperactivity suppresses the normal increase in [ADP] in hypoglycemia. Adenosine Diphosphate 55-58 glutamate dehydrogenase 1 Homo sapiens 0-5 29648519-15 2018 In hypoglycemia, however, GK activity is low and [ADP], a potent activator of GDH-1, increases. Adenosine Diphosphate 50-53 glutamate dehydrogenase 1 Homo sapiens 78-83 10722678-4 2000 Then, following exchange of ADP with ATP, a steady-state AP-clathrin-Hsc70-ATP complex forms that ties up Hsc70, preventing further uncoating. Adenosine Diphosphate 28-31 heat shock protein family A (Hsp70) member 8 Homo sapiens 69-74 29916540-7 2018 Notably, OC formation was efficiently restored by addition of adenosine diphosphate, a P2Y12 agonist, as well as by addition of CysLT. Adenosine Diphosphate 62-83 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 87-92 10722678-4 2000 Then, following exchange of ADP with ATP, a steady-state AP-clathrin-Hsc70-ATP complex forms that ties up Hsc70, preventing further uncoating. Adenosine Diphosphate 28-31 heat shock protein family A (Hsp70) member 8 Homo sapiens 106-111 29782832-5 2018 In addition, the contributions of Mg2+ to the kinetics and thermodynamics of ADP binding to Dbp5 were assessed. Adenosine Diphosphate 77-80 DEAD-box helicase 19B Homo sapiens 92-96 29782832-6 2018 Using a solution based in vitro approach, Mg2+ was found to slow ADP and ATP release from Dbp5 and increased the overall ADP and ATP affinities, as observed with other NTPases. Adenosine Diphosphate 65-68 DEAD-box helicase 19B Homo sapiens 90-94 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 DEAD-box helicase 19B Homo sapiens 79-83 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 DEAD-box helicase 19B Homo sapiens 155-159 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 DEAD-box helicase 19B Homo sapiens 155-159 29407897-2 2018 Phosphoglycerate kinase (PGK), an enzyme that converts 1,3-bisphosphoglycerate and adenosine diphosphate to 3-phosphoglycerate and adenosine triphosphate, has two isozymes: PGK1 and PGK2. Adenosine Diphosphate 83-104 phosphoglycerate kinase 2 Mus musculus 182-186 29470101-5 2018 The recombinant human GDH enzyme showed expected properties such as adenosine diphosphate activation and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate dual recognition. Adenosine Diphosphate 68-89 glutamate dehydrogenase 1 Homo sapiens 22-25 10704169-5 2000 Compared with Pl(A1,A1) platelets, Pl(A2)-positive platelets showed a gene dosage effect for significantly greater surface-expressed P-selectin, GP IIb/IIIa-bound fibrinogen, and activated GP IIb/IIIa in response to low-dose ADP. Adenosine Diphosphate 225-228 phospholipase A2 group IIA Homo sapiens 35-40 10656876-2 1999 Nucleoside [corrected] triphosphate diphosphohydrolase-1 (NTPDase-1, identical to CD39), the major vascular endothelial ectonucleotidase, is responsible for the hydrolysis of both extracellular ATP and ADP in the blood plasma to AMP. Adenosine Diphosphate 202-205 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 82-86 29182273-1 2017 Pyruvate kinase muscle isoform 2 (PKM2) catalyzes the terminal step in glycolysis, transferring a phosphoryl group from phosphoenolpyruvate to ADP, to produce pyruvate and ATP. Adenosine Diphosphate 143-146 pyruvate kinase M1/2 Homo sapiens 0-32 29182273-1 2017 Pyruvate kinase muscle isoform 2 (PKM2) catalyzes the terminal step in glycolysis, transferring a phosphoryl group from phosphoenolpyruvate to ADP, to produce pyruvate and ATP. Adenosine Diphosphate 143-146 pyruvate kinase M1/2 Homo sapiens 34-38 10543958-12 1999 These final slow steps are completely blocked when ADP occupies the second ring, i.e. it does not occur in the GroEL:ATP7:ADP7 or the GroEL:ATP7 species. Adenosine Diphosphate 51-54 heat shock protein family D (Hsp60) member 1 Homo sapiens 111-116 29234112-3 2017 We have found that the inactive conformations of the Tec kinase Itk and Src preferentially bind ADP over ATP, stabilising both proteins. Adenosine Diphosphate 96-99 IL2 inducible T cell kinase Homo sapiens 64-67 28753204-3 2017 Platelet-specific deletion of Ask1 in mice leads to defects in ADP-dependent platelet aggregation, unstable hemostasis and subsequent attenuation of tumor metastasis. Adenosine Diphosphate 63-66 mitogen-activated protein kinase kinase kinase 5 Mus musculus 30-34 10518593-6 1999 However, in the presence of cytoplasmic ADP (100 microM), SUR2A/Kir6.2 channels became as sensitive to diazoxide as SUR1/Kir6. Adenosine Diphosphate 40-43 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 64-70 28753204-5 2017 Mechanistically, ASK1-JNK/p38 axis phosphorylates an ADP receptor P2Y12 at Thr345, which is required for the ADP-dependent sustained Akt activity that is vital to normal platelet functions. Adenosine Diphosphate 53-56 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 17-21 10491184-8 1999 The purified MRP2-(His)6 glycoprotein was reconstituted into proteoliposomes and showed functional activity as ATPase in a protein-dependent manner with a Km for ATP of 2.1 mM and a Vmax of 25 nmol ADP x mg MRP2-1 x min-1. Adenosine Diphosphate 198-201 ATP binding cassette subfamily C member 2 Homo sapiens 13-17 10478836-7 1999 In contrast to Hsp90, binding of radicicol to Grp94 requires both the N-terminal ATP/ADP-binding domain as well as the adjacent negatively charged region. Adenosine Diphosphate 85-88 heat shock protein 90 beta family member 1 Homo sapiens 46-51 28888060-6 2017 We thus suggest that binding of myosin motors carrying ADP and Pi induces unidirectional conformational changes in actin filaments and allosterically recruits more myosin binding. Adenosine Diphosphate 55-58 myosin heavy chain 14 Homo sapiens 32-38 28888060-6 2017 We thus suggest that binding of myosin motors carrying ADP and Pi induces unidirectional conformational changes in actin filaments and allosterically recruits more myosin binding. Adenosine Diphosphate 55-58 myosin heavy chain 14 Homo sapiens 164-170 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 116-137 integrin subunit alpha 2b Homo sapiens 80-86 10411706-7 1999 These fragments also reduced the binding of PAC-1, an activation-dependent anti-GP IIb-IIIa monoclonal antibody, to adenosine diphosphate (ADP)-activated normal platelets. Adenosine Diphosphate 139-142 integrin subunit alpha 2b Homo sapiens 80-86 29054115-5 2017 ADP-ribosylation of DNA mediated by PARP3 attaches a single mono-ADP-ribose moiety to the phosphate group at the terminal ends of DNA. Adenosine Diphosphate 0-3 poly(ADP-ribose) polymerase family member 3 Homo sapiens 36-41 10338478-2 1999 This cell-invasive adenylate cyclase completely suppressed ADP (10 microM)-induced aggregation of rabbit platelets at 3 micrograms/ml and strongly suppressed thrombin (0. Adenosine Diphosphate 59-62 prothrombin Oryctolagus cuniculus 158-166 29155852-14 2017 Decreasing ADP-induced aggregation is particularly caused by the impairment of the purinergic receptor P2Y1 activity. Adenosine Diphosphate 11-14 purinergic receptor P2Y1 Homo sapiens 103-107 10350604-1 1999 We characterized the thermodynamics of binding reactions of nucleotides ADP and ATPgammaS (a nonhydrolyzable analog of ATP) to GroEL in a temperature range of 5 degrees C to 35 degrees C by isothermal titration calorimetry. Adenosine Diphosphate 72-75 heat shock protein family D (Hsp60) member 1 Homo sapiens 127-132 29165759-8 2017 TRPM4 protein contains many regulatory motifs that confer voltage dependence, ATP/ADP sensitivity, and Ca2+ responsiveness. Adenosine Diphosphate 82-85 transient receptor potential cation channel subfamily M member 4 Homo sapiens 0-5 10350604-3 1999 The stoichiometries of binding were about 8 and 9 molecules for ADP and ATPgammaS, respectively, per GroEL tetradecamer at 5 degrees C, and both increased with temperature to reach about 14 (ADP) and 12 (ATPgammaS) for both nucleotides at 35 degrees C. The absence of initial increase of binding heat as well as Hill coefficient less than 1.2, which were obtained from the fitting to the model curve by assuming positive cooperativity, showed that there was virtually no positive cooperativity in the nucleotide bindings. Adenosine Diphosphate 64-67 heat shock protein family D (Hsp60) member 1 Homo sapiens 101-106 10350604-3 1999 The stoichiometries of binding were about 8 and 9 molecules for ADP and ATPgammaS, respectively, per GroEL tetradecamer at 5 degrees C, and both increased with temperature to reach about 14 (ADP) and 12 (ATPgammaS) for both nucleotides at 35 degrees C. The absence of initial increase of binding heat as well as Hill coefficient less than 1.2, which were obtained from the fitting to the model curve by assuming positive cooperativity, showed that there was virtually no positive cooperativity in the nucleotide bindings. Adenosine Diphosphate 191-194 heat shock protein family D (Hsp60) member 1 Homo sapiens 101-106 28963484-1 2017 ADP-ribosylhydrolases (ARH1, ARH2 and ARH3) are a family of enzymes to catalyze ADP-ribosylation, a reversible and covalent post-translational modification (PTM). Adenosine Diphosphate 0-3 ADP-ribosylserine hydrolase Homo sapiens 38-42 28911206-10 2017 In conclusion, the GDH-S445L mutation confers hyperactivity to this enzyme due to higher sensitivity to ADP allosteric activation. Adenosine Diphosphate 104-107 glutamate dehydrogenase 1 Homo sapiens 19-22 10350604-4 1999 Incorporating a difference in affinity for the nucleotide (ADP and ATPgammaS) between the two rings of GroEL into the noncooperative binding model improved the goodness of fitting and the difference in the affinity increased with decreasing temperature. Adenosine Diphosphate 59-62 heat shock protein family D (Hsp60) member 1 Homo sapiens 103-108 10318853-4 1999 Their activation by nucleotide agonists (ADP and ATP for P2Y1; ATP and UTP for P2Y2) elevates [Ca2+]i and moderately induces expression of the c-fos proto-oncogene. Adenosine Diphosphate 41-44 purinergic receptor P2Y2 Homo sapiens 79-83 28900295-5 2017 Remarkably, our results show that ChR2-induced Ca2+ increase and subsequent glutamate release are amplified by ATP/ADP-mediated autocrine activation of P2Y1 receptors on astrocytes. Adenosine Diphosphate 115-118 purinergic receptor P2Y1 Homo sapiens 152-156 10318853-4 1999 Their activation by nucleotide agonists (ADP and ATP for P2Y1; ATP and UTP for P2Y2) elevates [Ca2+]i and moderately induces expression of the c-fos proto-oncogene. Adenosine Diphosphate 41-44 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 143-148 10194444-4 1999 Both Syk null murine platelets and piceatannol-treated human platelets exhibited a partial, but statistically significant defect in activation of alphaIIbbeta3 by adenine diphosphate (ADP) +/- epinephrine as assessed by fibrinogen binding. Adenosine Diphosphate 184-187 spleen tyrosine kinase Mus musculus 5-8 28400185-6 2017 Cc-Lec inhibited platelet aggregation induced by ADP, arachidonic acid or fibrinogen suggesting its interaction with their specific receptors namely P2Y1 and/or P2Y12, GPIIb/IIIa and TPalpha respectively. Adenosine Diphosphate 49-52 laryngotracheo esophageal cleft Mus musculus 3-6 10395457-6 1999 When ADP, ATP, or AMP-PNP were added to a solution of GroEL and Mg2+, C138 incorporated approximately 0.8 labels, while C458 incorporated approximately 0.1 labels. Adenosine Diphosphate 5-8 heat shock protein family D (Hsp60) member 1 Homo sapiens 54-59 10051438-4 1999 In vitro kinase assays with anti-beta3 precipitates demonstrated that syk activity was enhanced in ADP-stimulated platelets. Adenosine Diphosphate 99-102 spleen associated tyrosine kinase Homo sapiens 70-73 28655760-7 2017 Metabolically, knockdown of SLC13A5 in HepG2 and Huh7 cells was associated with a decrease in intracellular levels of citrate, the ratio of ATP/ADP, phospholipid content, and ATP citrate lyase expression. Adenosine Diphosphate 144-147 solute carrier family 13 member 5 Homo sapiens 28-35 10331637-4 1999 A series of blockers of the BFA-dependent ADP-ribosylation reaction identified in our laboratory inhibited the effects of BFA on Golgi morphology and, with similar potency, the ADP-ribosylation of BARS-50 and GAPDH. Adenosine Diphosphate 42-45 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 209-214 28759073-1 2017 The ecto-nucleoside triphosphate diphosphohydrolase-1 (E-NTPDase-1, CD39) enzyme is responsible for the breakdown of extracellular ATP to ADP and then to AMP by a two-step process. Adenosine Diphosphate 138-141 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 55-66 28759073-1 2017 The ecto-nucleoside triphosphate diphosphohydrolase-1 (E-NTPDase-1, CD39) enzyme is responsible for the breakdown of extracellular ATP to ADP and then to AMP by a two-step process. Adenosine Diphosphate 138-141 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 68-72 10026164-1 1999 Changes in the vibrational spectrum of the chaperonin GroEL in the presence of ADP and ATP have been followed as a function of time using rapid scan Fourier transform infrared spectroscopy. Adenosine Diphosphate 79-82 heat shock protein family D (Hsp60) member 1 Homo sapiens 54-59 10326681-4 1999 The ATP-binding sites in both fusion proteins had the same nucleotide specificity as found for the intact IP3R (ATP > ADP > AMP > GTP). Adenosine Diphosphate 121-124 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 106-110 28686615-8 2017 Genetic or pharmacologic inhibition of STAT3 significantly increased myocyte ADP/ATP ratio and enhanced autophagy through AMPKalpha/mTOR signaling. Adenosine Diphosphate 77-80 signal transducer and activator of transcription 3 Rattus norvegicus 39-44 10021912-2 1999 They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation. Adenosine Diphosphate 85-88 integrin subunit alpha 2b Homo sapiens 24-29 28302652-1 2017 Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) degrades the purines ATP and ADP that are key regulators of inflammation and clotting. Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-48 28302652-1 2017 Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase1) degrades the purines ATP and ADP that are key regulators of inflammation and clotting. Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 50-58 9914513-4 1999 The similar sensitivity to K+ of the temperature range where activation of the GroEL ATPase activity, the low temperature endotherm, and the increase of the ANS fluorescence are abserved strongly indicates the existence of a conformational state of GroEL during ATP hydrolysis, different from that generated on ADP or AMP-PNP binding. Adenosine Diphosphate 311-314 heat shock protein family D (Hsp60) member 1 Homo sapiens 249-254 28414123-6 2017 ZGR also inhibited ADP- and U46619- induced phosphorylation of myristolated alanine-rich C-kinase substrate (MARCKS) and the expressions of P-selectin and PAC-1 in platelets. Adenosine Diphosphate 19-22 dual specificity phosphatase 2 Mus musculus 155-160 10754379-2 1999 All 3 drugs inhibited platelet aggregation response to ADP, collagen, epinephrine and arachidonic acid (p < 0.05), but not to ristocetin. Adenosine Diphosphate 55-58 paired box 5 Homo sapiens 0-5 28502718-4 2017 The ectopically over-expressed ND5:P265H in mitochondria resulted in a reduced Complex I activity, generation of higher ADP/ATP ratio, reactive oxygen species (ROS) and carbonylation of proteins as compared to mock-transfected cells. Adenosine Diphosphate 120-123 mitochondrially encoded NADH dehydrogenase 5 Homo sapiens 31-34 27862653-2 2017 Central players in adenosine signaling are the ectonucleotidases CD39 and CD73, which convert ADP/ATP to AMP and AMP to adenosine, respectively. Adenosine Diphosphate 94-97 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 65-69 9857072-8 1998 These results are consistent with a model for the ATPase cycle in which ATP hydrolysis occurs on the microtubule followed by detachment as the Ncd.ADP.Pi intermediate. Adenosine Diphosphate 147-150 ATPase Escherichia coli 50-56 28115185-2 2017 In the present investigation, we observe that huPK pretreatment of platelets potentiates ADP-induced platelet activation by prior proteolysis of the G-protein-coupled receptor PAR-1. Adenosine Diphosphate 89-92 Prader Willi/Angelman region RNA 1 Homo sapiens 176-181 9790974-0 1998 PAP gene transcription induced by cycloheximide in AR4-2J cells involves ADP-ribosylation. Adenosine Diphosphate 73-76 regenerating family member 3 beta Rattus norvegicus 0-3 28115185-4 2017 Integrin alphaIIbbeta3 is a cofactor for huPK binding to platelets to support PAR-1 hydrolysis that contributes to activation of the ADP signaling pathway. Adenosine Diphosphate 133-136 Prader Willi/Angelman region RNA 1 Homo sapiens 78-83 27696674-4 2017 Principal component analysis performed by using molecular dynamics trajectories suggests that binding of ADP and ATP to extracellular signal-regulated kinase 2 change motion directions of two helices alpha1 and alpha2. Adenosine Diphosphate 105-108 adrenoceptor alpha 1D Homo sapiens 200-206 9718317-3 1998 Although unable to promote binding to DNA, ATP-gamma-S also prevents inactivation of Rad51 at 37 degrees C. AMP-P-N-P lacks this property, while ADP protects partially but only at 5-10 times higher concentrations than ATP. Adenosine Diphosphate 145-148 RAD51 recombinase Homo sapiens 85-90 9708818-13 1998 This switch may involve a posttranslational modification of VEGF, possibly by the process of ADP-ribosylation. Adenosine Diphosphate 93-96 vascular endothelial growth factor A Mus musculus 60-64 9767192-5 1998 The rate constant of the rate-limiting reaction--MgADP release during formation of the superreduced state of Av1 (*Av12-)--is 12 +/- 2 sec-1. Adenosine Diphosphate 49-54 secretory blood group 1, pseudogene Homo sapiens 135-140 9675167-7 1998 We suggest that in the presence of ATP kinesin"s putative microtubule binding regions L8, L12, L11, alpha4, alpha5, and alpha6 form a face complementary in shape to the microtubule surface; in the presence of ADP, the microtubule binding face adopts a more convex shape relative to the ATP-bound form, reducing kinesin"s affinity to the microtubule. Adenosine Diphosphate 209-212 immunoglobulin kappa variable 1-6 Homo sapiens 95-98 9675167-7 1998 We suggest that in the presence of ATP kinesin"s putative microtubule binding regions L8, L12, L11, alpha4, alpha5, and alpha6 form a face complementary in shape to the microtubule surface; in the presence of ADP, the microtubule binding face adopts a more convex shape relative to the ATP-bound form, reducing kinesin"s affinity to the microtubule. Adenosine Diphosphate 209-212 immunoglobulin binding protein 1 Homo sapiens 100-126 9657959-11 1998 However, NTPase activity was specifically stimulated by the viral NS5 protein, which was manifested by a more than twofold increase in the rate of ATP hydrolysis and a 25% increase in the yield of ADP at the end of a 120-min reaction. Adenosine Diphosphate 197-200 inosine triphosphatase Homo sapiens 9-15 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 134-139 9531051-3 1998 ADP-induced platelet aggregation in PRP was also significantly prevented by MB (1-10 microM). Adenosine Diphosphate 0-3 proline rich protein 2-like 1 Rattus norvegicus 36-39 9453549-4 1998 Analysis of cellular energy nucleotides showed an increase of the ADP/ATP ratio after reoxygenation, which synchronized with activation of the HSP promoter. Adenosine Diphosphate 66-69 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 143-146 9453549-5 1998 Activation of the HSP promoter was also observed after an addition of iodoacetic acid to hypoxic astrocytes, which reached the maximum when the ADP/ATP ratio reached 50%, but further decline in the energy profile caused inactivation of this promoter. Adenosine Diphosphate 144-147 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 18-21 9435321-5 1998 In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Adenosine Diphosphate 97-100 glycoprotein Ib platelet subunit alpha Homo sapiens 212-232 9396736-9 1997 We found that generation of tryptic fragments, including the loop linking transmembrane (TM) regions TM8 and TM9 of Pgp, were stimulated by the binding of Mg-p[NH]ppA, MgATP and MgADP, indicating that the Pgp conformation was changed by the binding of these nucleotides. Adenosine Diphosphate 178-183 tetraspanin 16 Homo sapiens 101-104 9341138-4 1997 In this report, the binding of GroES to highly purified GroEL in the presence of ATP, ADP, and the nonhydrolyzable ATP analogue, 5"-adenylyl beta,gamma-imidodiphosphate (AMP-PNP), was investigated by using the fluorescence anisotropy of succinimidyl-1-pyrenebutyrate-labeled GroES. Adenosine Diphosphate 86-89 chaperonin GroES Escherichia coli 31-36 9341138-6 1997 In contrast, in the presence of ADP or AMP-PNP only one molecule of oligomeric GroES can be tightly bound by GroEL. Adenosine Diphosphate 32-35 chaperonin GroES Escherichia coli 79-84 9341138-8 1997 In the presence of ADP alone, a second GroES ring can bind to GroEL weakly and with negative cooperativity. Adenosine Diphosphate 19-22 chaperonin GroES Escherichia coli 39-44 9202074-6 1997 Microinjection of RhoT19N, a dominant negative form of RhoA, or in vitro ADP-ribosylated RhoA impaired the ability of cells to migrate. Adenosine Diphosphate 73-76 ras homolog family member A Rattus norvegicus 89-93 9202705-3 1997 We report that substitution of ATP-affinity chromatography by ADP-affinity chromatography results in isolation of Hsp70 molecules which are still associated with peptides and are immunogenic. Adenosine Diphosphate 62-65 heat shock protein family A (Hsp70) member 4 Homo sapiens 114-119 9100026-6 1997 The binding also required ATP; Hsc70 dissociated from baskets with a 6 min half-life when ATP was hydrolyzed to ADP. Adenosine Diphosphate 112-115 heat shock protein family A (Hsp70) member 8 Homo sapiens 31-36 9108300-5 1997 The interaction of GroEL with GroES in the presence of Mg2+-ADP eliminates the destabilizing effect of ADP on the GroEL molecule against the action of temperature and Ellman"s reagent but does not change its hydrophobicity and accessibility to trypsin. Adenosine Diphosphate 60-63 chaperonin GroES Escherichia coli 30-35 9045625-4 1997 Both this binding and polymerization required ATP; the Hsc70 depolymerized with a 4-min half-life when ATP was completely hydrolyzed to ADP. Adenosine Diphosphate 136-139 heat shock protein family A (Hsp70) member 8 Homo sapiens 55-60 9119254-7 1997 In GGT-rich HepG2 human hepatoma cells, the exposure to GSH, glycyl-glycine, and ADP-chelated iron resulted in a nontoxic lipid peroxidation process, which could be prevented by means of GGT inhibitors such as acivicin and the serine-boric acid complex. Adenosine Diphosphate 81-84 inactive glutathione hydrolase 2 Homo sapiens 187-190 8998163-5 1997 The binding of P748 peptide and [ReO]P748 to GPIIb/IIIa receptors on activated platelets was assessed by their inhibition of ADP stimulated human platelet aggregation in platelet rich plasma (PRP). Adenosine Diphosphate 125-128 integrin subunit alpha 2b Homo sapiens 45-50 28039042-9 2017 We conclude that a major contribution of LVA calcium channels to ADP determines the bursting capability of CA1 pyramidal neurons during a transitional postnatal period in contrast to adulthood. Adenosine Diphosphate 65-68 carbonic anhydrase 1 Rattus norvegicus 107-110 8955216-3 1996 Ca2+ release from intracellular Ca2+ stores induced by anti-CD9 mAb depended almost totally upon thromboxane A2 production and released ADP, whereas that induced by Fc gammaRII was affected only minimally by these factors. Adenosine Diphosphate 136-139 CD9 molecule Homo sapiens 60-63 27916641-8 2017 UCP1 is certainly a unique mitochondrial transporter able to uncouple respiration from ADP phosphorylation in mitochondria. Adenosine Diphosphate 87-90 uncoupling protein 1 Homo sapiens 0-4 8977459-9 1996 Flow cytometry confirmed that the number of ligand-occupied GP IIb/IIIa complexes was much lower on platelets stimulated with ADP or 2-MeS-ADP after clopidogrel treatment. Adenosine Diphosphate 126-129 integrin subunit alpha 2b Homo sapiens 60-66 27815804-8 2017 I propose that if a blockade of purinergic signaling in platelets is a potential lung-protective strategy in the treatment of acute inflammation, then it is more likely to be a result of the disruption of the signaling pathway mediated by P2Y12, another G protein-coupled receptor that mediates platelet responses to ADP. Adenosine Diphosphate 317-320 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 239-244 28190975-5 2017 Reactivity to ADP or oral bacteria was assessed by flow cytometric analysis of membrane markers (binding of PAC-1, P-selectin, CD63) and platelet-leukocyte complex formation. Adenosine Diphosphate 14-17 selectin P Homo sapiens 115-125 28190975-5 2017 Reactivity to ADP or oral bacteria was assessed by flow cytometric analysis of membrane markers (binding of PAC-1, P-selectin, CD63) and platelet-leukocyte complex formation. Adenosine Diphosphate 14-17 CD63 molecule Homo sapiens 127-131 8929451-3 1996 A 42-kDa substrate for NO-dependent ADP-ribosylation was identified as actin by binding to DNAse-I and immunoprecipitation with anti-actin antibodies. Adenosine Diphosphate 36-39 deoxyribonuclease I Mus musculus 91-98 8861908-3 1996 Using cryo-electron microscopy, we have obtained three-dimensional reconstructions to 30 A resolution for GroEL and GroEL-GroES complexes in the presence of ADP, ATP, and the nonhydrolyzable ATP analog, AMP-PNP. Adenosine Diphosphate 157-160 heat shock protein family D (Hsp60) member 1 Homo sapiens 106-111 8861908-3 1996 Using cryo-electron microscopy, we have obtained three-dimensional reconstructions to 30 A resolution for GroEL and GroEL-GroES complexes in the presence of ADP, ATP, and the nonhydrolyzable ATP analog, AMP-PNP. Adenosine Diphosphate 157-160 heat shock protein family D (Hsp60) member 1 Homo sapiens 116-121 8964080-4 1996 Similarly, the ADP-ribosylating G-protein-reactive pertussis toxin (PTX) but not a mutant toxin lacking the ADP-ribosylating moiety (mPTX) prevents apoptosis induction. Adenosine Diphosphate 15-18 mucosal pentraxin 1 Mus musculus 68-71 8702478-3 1996 The P2Y7 cDNA was transiently expressed in COS-7 cells: binding studies thereon showed a very high affinity for ATP (37 +/- 6 nM), much less for UTP and ADP (approximately 1300 nM), and a novel rank order of affinities in the binding series studied of 8 nucleotides and suramin. Adenosine Diphosphate 153-156 leukotriene B4 receptor Homo sapiens 4-8 8702492-3 1996 Whereas in the presence of ADP, HSC70 exists as a slow, concentration- and temperature-dependent monomer-oligomer equilibrium, in the presence of ATP, the protein is essentially monomeric, indicating that ATP shifts this equilibrium toward the monomer by stabilizing the monomer. Adenosine Diphosphate 27-30 heat shock protein family A (Hsp70) member 8 Homo sapiens 32-37 8670798-2 1996 In the presence of hsp70 (hsc70), hdj-1 and either ATP or ADP, denatured beta-galactosidase refolds and forms enzymatically active tetramers. Adenosine Diphosphate 58-61 heat shock protein family A (Hsp70) member 4 Homo sapiens 19-24 8670798-2 1996 In the presence of hsp70 (hsc70), hdj-1 and either ATP or ADP, denatured beta-galactosidase refolds and forms enzymatically active tetramers. Adenosine Diphosphate 58-61 heat shock protein family A (Hsp70) member 8 Homo sapiens 26-31 8647294-2 1996 In the presence of 10% (w/v) dextran M20 or bovine serum albumin, approximately 60% of the maximal ADP flux from adenylate kinase to oxidative phosphorylation was not accessible to an extramitochondrial ADP scavenger. Adenosine Diphosphate 99-102 albumin Rattus norvegicus 51-64 8647294-2 1996 In the presence of 10% (w/v) dextran M20 or bovine serum albumin, approximately 60% of the maximal ADP flux from adenylate kinase to oxidative phosphorylation was not accessible to an extramitochondrial ADP scavenger. Adenosine Diphosphate 203-206 albumin Rattus norvegicus 51-64 8965144-2 1996 METHODS: The affinity and specificity of P280 peptide for the GPIIb/IIIa receptor was assessed by the inhibition of ADP-stimulated human platelet aggregation, the inhibition of the binding of fibrinogen to the GPIIb/IIIa receptor and the inhibition of the binding of vitronectin to the vitronectin receptor. Adenosine Diphosphate 116-119 integrin subunit alpha 2b Homo sapiens 62-67 8907715-4 1996 The Hsc70-ATP complex is turned over to Hsc70-ADP center dot Pi, from which phosphate is slowly released. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 8 Bos taurus 4-9 8907715-4 1996 The Hsc70-ATP complex is turned over to Hsc70-ADP center dot Pi, from which phosphate is slowly released. Adenosine Diphosphate 46-49 heat shock protein family A (Hsp70) member 8 Bos taurus 40-45 8907715-5 1996 The resulting Hsc70-ADP complex exchanges ATP for ADP. Adenosine Diphosphate 20-23 heat shock protein family A (Hsp70) member 8 Bos taurus 14-19 7547923-2 1995 We previously observed major differences in the effect of bound ATP and ADP on the interaction of hsc70 (constitutive hsp70) with its protein substrates. Adenosine Diphosphate 72-75 heat shock protein family A (Hsp70) member 8 Homo sapiens 98-103 7547923-2 1995 We previously observed major differences in the effect of bound ATP and ADP on the interaction of hsc70 (constitutive hsp70) with its protein substrates. Adenosine Diphosphate 72-75 heat shock protein family A (Hsp70) member 4 Homo sapiens 118-123 7547923-5 1995 Specifically, nucleotide-free hsc70 behaved much more like hsc70-ATP than hsc70-ADP in that clathrin very rapidly bound to and dissociated from nucleotide-free hsc70 in contrast to its very slow binding to and dissociation from hsc70-ADP. Adenosine Diphosphate 234-237 heat shock protein family A (Hsp70) member 8 Homo sapiens 30-35 7547923-6 1995 On the other hand, nucleotide-free hsc70 behaved more like hsc70-ADP than hsc70-ATP in that cytochrome c peptide dissociated very slowly from nucleotide-free hsc70 compared to its rapid dissociation from hsc70-ATP. Adenosine Diphosphate 65-68 heat shock protein family A (Hsp70) member 8 Homo sapiens 59-64 7547923-6 1995 On the other hand, nucleotide-free hsc70 behaved more like hsc70-ADP than hsc70-ATP in that cytochrome c peptide dissociated very slowly from nucleotide-free hsc70 compared to its rapid dissociation from hsc70-ATP. Adenosine Diphosphate 65-68 heat shock protein family A (Hsp70) member 8 Homo sapiens 59-64 7547923-6 1995 On the other hand, nucleotide-free hsc70 behaved more like hsc70-ADP than hsc70-ATP in that cytochrome c peptide dissociated very slowly from nucleotide-free hsc70 compared to its rapid dissociation from hsc70-ATP. Adenosine Diphosphate 65-68 heat shock protein family A (Hsp70) member 8 Homo sapiens 59-64 7547923-6 1995 On the other hand, nucleotide-free hsc70 behaved more like hsc70-ADP than hsc70-ATP in that cytochrome c peptide dissociated very slowly from nucleotide-free hsc70 compared to its rapid dissociation from hsc70-ATP. Adenosine Diphosphate 65-68 heat shock protein family A (Hsp70) member 8 Homo sapiens 59-64 7650011-6 1995 The KD value remained almost unchanged when GroES and/or 10 microM ADP was included in the GroEL solution. Adenosine Diphosphate 67-70 heat shock protein family D (Hsp60) member 1 Homo sapiens 91-96 7650011-7 1995 However, when 1 mM ADP was included, the KD value of GroEL increased by 2 orders of magnitude solely due to the change in koff. Adenosine Diphosphate 19-22 heat shock protein family D (Hsp60) member 1 Homo sapiens 53-58 7650011-9 1995 These results indicate that GroEL/ES has high and low affinity ADP binding sites and that occupation of the low affinity sites by ADP was responsible for the loss of ability to interact with the substrate protein. Adenosine Diphosphate 130-133 heat shock protein family D (Hsp60) member 1 Homo sapiens 28-33 7629128-4 1995 The asymmetric complexes that form in the presence of ADP are "bullet-shaped" particles that likely consist of 1 mol each of ch-cpn60 and ch-cpn10. Adenosine Diphosphate 54-57 heat shock protein family D (Hsp60) member 1 Homo sapiens 128-133 7758459-9 1995 A restriction fragment containing the UAS conferred oxygen and carbon source regulation when placed upstream of another yeast gene encoding ADP/ATP carrier (AAC3), deleted of its regulatory sequences. Adenosine Diphosphate 140-143 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 157-161 7890675-5 1995 In contrast, productive binding of the ADP/ATP carrier was not inhibited by salt, the presequence peptide, or a deletion of Mas20p, but was strongly dependent on Mas37p/Mas70p. Adenosine Diphosphate 39-42 Tom20p Saccharomyces cerevisiae S288C 124-130 7836458-3 1995 Crystallographic anomalous scattering from potassium at 1.7 A resolution reveals two monovalent ions that interact with MgADP and P(i) in the nucleotide binding cleft of wild-type recombinant bovine Hsc70 ATPase fragment. Adenosine Diphosphate 120-125 heat shock protein family A (Hsp70) member 8 Bos taurus 199-204 7713147-2 1995 FK409 and TRK-100 inhibited ADP-induced platelet aggregation in rat platelet-rich plasma at 1.0 and 0.032 microM, respectively. Adenosine Diphosphate 28-31 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 10-13 7813481-12 1994 Interaction of PTPA with PP2A in a 1:1 ratio induces a low (kcat = 3 min-1) ATPase activity that is inhibited by okadaic acid, ADP and non-hydrolysable ATP analogues. Adenosine Diphosphate 127-130 serine/threonine-protein phosphatase 2A activator Oryctolagus cuniculus 15-19 7957255-7 1994 These results suggest that upon stimulation by collagen p72syk is physically activated by a process that is independent of the effects of Ca2+, ADP, and actin polymerization, and may participate in the regulation of Ca2+ mobilization mediated by collagen in platelets. Adenosine Diphosphate 144-147 spleen associated tyrosine kinase Homo sapiens 56-62 28069995-5 2017 We show that the export is dependent on the phosphorylation of two SQ/TQ motifs, suggesting a novel direct interaction between ATM and ADP-ribosylation. Adenosine Diphosphate 135-138 ATM serine/threonine kinase Homo sapiens 127-130 27863418-2 2016 This study aimed to investigate the importance of Pin1 expression in human dental pulp cells (hDPCs) to understand the involvement of Pin1 in the regulation of P2Y1 and the activation of ADP-mediated P2Y1 signaling. Adenosine Diphosphate 187-190 purinergic receptor P2Y1 Homo sapiens 200-204 8045941-7 1994 We conclude that RhoA is essential for receptor-mediated force generation and ensuing neurite retraction in N1E-115 and PC12 cells, and that inactivation of RhoA by ADP-ribosylation abolishes actomyosin contractility and promotes neurite outgrowth. Adenosine Diphosphate 165-168 ras homolog family member A Rattus norvegicus 157-161 27769837-7 2016 A seven-fold enhancement of acquisition (kred/Kd) for 6-dihydronicotinamide riboside was observed for human renalase in the presence of ADP. Adenosine Diphosphate 136-139 renalase, FAD dependent amine oxidase Homo sapiens 108-116 28344879-1 2017 CD39 and CD73 are surface-expressed ectonucleotidases that hydrolyze ATP in a highly regulated, serial manner into ADP, AMP and adenosine. Adenosine Diphosphate 115-118 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 7921602-13 1994 It is concluded that 2MeSATP and low concentrations of 2ClATP and ADP induce intracellular Ca2+ mobilization by acting via an atypical P2y purinoceptor that is not coupled to phospholipase C. At high concentrations, 2ClATP also activates phospholipase C and further increases [Ca2+]i probably by acting on P2u purinoceptors. Adenosine Diphosphate 66-69 ATP citrate lyase Homo sapiens 217-222 27717739-4 2016 Recent structural insights into the powerstroke have come from a high-resolution structure of myosin in a previously unseen state and from an electron cryomicroscopy (cryo-EM) 3D reconstruction of the actin-myosin-MgADP complex. Adenosine Diphosphate 214-219 myosin heavy chain 14 Homo sapiens 207-213 7993797-3 1994 Out of 30 monoclonal antibodies reacting with GPIIb/IIIa, one, MA-16N7C2, potently inhibited platelet aggregation induced by ADP, thrombin, arachidonic acid, collagen, U46619, adrenaline and platelet-activating factor, whereas ristocetin-induced aggregation was unaffected. Adenosine Diphosphate 125-128 integrin subunit alpha 2b Homo sapiens 46-51 26861857-5 2016 Patient age was independently associated with ADP-inducible P-selectin expression, GPIIb/IIIa, and MPA formation (all P < .05). Adenosine Diphosphate 46-49 selectin P Homo sapiens 60-70 8132533-9 1994 We propose that GMPS-BDB (or AMPS-BDB), which may exist in enolized form in aqueous solution, functions as a reactive analogue of phosphoenolpyruvate and GDP (ADP) to target Cys151 in the active site of pyruvate kinase. Adenosine Diphosphate 159-162 GMP synthase [glutamine-hydrolyzing] Oryctolagus cuniculus 16-20 26875616-4 2016 Thus, we presumed that pyrophosphate and ADP released thin filaments composed of actin, and thick filaments composed of myosin from restraints of myofibrils, and then both filaments were solubilized through the IMP-induced dissociation of actomyosin. Adenosine Diphosphate 41-44 myosin heavy chain 14 Homo sapiens 120-126 7709802-3 1994 The monomer units are assembled in the filament in a head-to-tail arrangement in a helical manner, similar to the organization of RecA molecules found in the crystal of pure RecA or including ADP. Adenosine Diphosphate 192-195 RAD51 recombinase Homo sapiens 130-134 26674810-12 2016 However, the impairment of P2X1 and especially of P2Y1 receptor function indicated by decreased receptor-mediated calcium flux is an important mechanism contributing to reduced ADP responsiveness of stored platelets. Adenosine Diphosphate 177-180 purinergic receptor P2Y1 Homo sapiens 50-63 7515044-6 1994 In addition, the percent expression of P-selectin and activated GpIIb/IIIa in response to ADP was reproducible in each individual studied on five separate occasions (CV < or = 8%). Adenosine Diphosphate 90-93 integrin subunit alpha 2b Homo sapiens 64-69 8267592-1 1993 Arginine-specific mono(ADP-ribosyl)transferase purified from rabbit skeletal muscle catalyzes stoichiometric ADP-ribosylation of the intermediate filament protein, desmin. Adenosine Diphosphate 23-26 desmin Oryctolagus cuniculus 164-170 27693233-1 2016 Mutations in SLC25A4 encoding the mitochondrial ADP/ATP carrier AAC1 are well-recognized causes of mitochondrial disease. Adenosine Diphosphate 48-51 solute carrier family 25 member 4 Homo sapiens 13-20 27693233-1 2016 Mutations in SLC25A4 encoding the mitochondrial ADP/ATP carrier AAC1 are well-recognized causes of mitochondrial disease. Adenosine Diphosphate 48-51 solute carrier family 25 member 4 Homo sapiens 64-68 27693233-7 2016 We show that both recombinant AAC1 mutant proteins are severely impaired in ADP/ATP transport, affecting most likely the substrate binding and mechanics of the carrier, respectively. Adenosine Diphosphate 76-79 solute carrier family 25 member 4 Homo sapiens 30-34 8267592-2 1993 In contrast, cholera toxin catalyzes a much lower level of ADP-ribosylation of desmin. Adenosine Diphosphate 59-62 desmin Oryctolagus cuniculus 79-85 8267592-4 1993 Phosphorylation of desmin by the catalytic subunit of cAMP dependent protein kinase is also inhibited by ADP-ribosylation. Adenosine Diphosphate 105-108 desmin Oryctolagus cuniculus 19-25 8227009-3 1993 Pretreatment of the cells with the C3 exoenzyme caused ADP-ribosylation of rho p21 in the cells and selectively attenuated the phosphorylation of several proteins, including p43 mitogen-activated protein kinase, p125 focal adhesion kinase, and two proteins of 72 and 88 kDa. Adenosine Diphosphate 55-58 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 79-82 27515424-7 2016 P-selectin exposure and GPIIbIIIa activation in unstimulated platelets and platelets stimulated with collagen-related peptide (CRP) or adenosine diphosphate (ADP) in thrombocytopenic samples and the normocytic control from which they were derived were quantified by flow cytometry. Adenosine Diphosphate 135-156 selectin P Homo sapiens 0-10 27515424-7 2016 P-selectin exposure and GPIIbIIIa activation in unstimulated platelets and platelets stimulated with collagen-related peptide (CRP) or adenosine diphosphate (ADP) in thrombocytopenic samples and the normocytic control from which they were derived were quantified by flow cytometry. Adenosine Diphosphate 158-161 selectin P Homo sapiens 0-10 27515424-9 2016 P-selectin exposure and GPIIbIIIa activation on unstimulated platelets or on ADP- or CRP-stimulated platelets did not differ in thrombocytopenic samples compared to normocytic controls. Adenosine Diphosphate 77-80 selectin P Homo sapiens 0-10 8344989-0 1993 Interaction of facilitative glucose transporter with glucokinase and its modulation by ADP and glucose-6-phosphate. Adenosine Diphosphate 87-90 glucokinase Homo sapiens 53-64 27534720-8 2016 SMCs from P2ry12-/- mice were resistant to senescence induced by excessive mechanical stretch or ADP treatment. Adenosine Diphosphate 97-100 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 10-16 27062501-8 2016 We sought to determine the role in this process of the AMP-activated protein kinase (AMPK), which is intimately coupled to mitochondrial function due to its activation by LKB1-dependent phosphorylation in response to increases in the cellular AMP:ATP and/or ADP:ATP ratios. Adenosine Diphosphate 258-261 serine/threonine kinase 11 Homo sapiens 171-175 27172914-6 2016 ADP inhibited currents through Cav2.2 channels via both P2Y1 and P2Y12 receptors with phospholipase C and pertussis toxin-sensitive G proteins being involved, respectively. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 56-60 27460867-1 2016 Human purinergic G protein-coupled receptor P2Y1 (P2Y1 R) is activated by adenosine 5"-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Adenosine Diphosphate 74-98 purinergic receptor P2Y1 Homo sapiens 44-48 27460867-1 2016 Human purinergic G protein-coupled receptor P2Y1 (P2Y1 R) is activated by adenosine 5"-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Adenosine Diphosphate 74-98 purinergic receptor P2Y1 Homo sapiens 50-54 27460867-1 2016 Human purinergic G protein-coupled receptor P2Y1 (P2Y1 R) is activated by adenosine 5"-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Adenosine Diphosphate 100-103 purinergic receptor P2Y1 Homo sapiens 44-48 8457580-4 1993 (3) These data can be explained by a substantial decrease in the cytosolic free concentration ratio of ATP/ADP acting on the equilibrium of glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase. Adenosine Diphosphate 107-110 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 140-180 27460867-1 2016 Human purinergic G protein-coupled receptor P2Y1 (P2Y1 R) is activated by adenosine 5"-diphosphate (ADP) to induce platelet activation and thereby serves as an important antithrombotic drug target. Adenosine Diphosphate 100-103 purinergic receptor P2Y1 Homo sapiens 50-54 27460867-6 2016 However, binding of ADP breaks this ionic lock, forming a continuous water channel that leads to P2Y1 R activation. Adenosine Diphosphate 20-23 purinergic receptor P2Y1 Homo sapiens 97-101 8477727-0 1993 Transcriptional control of AAC3 gene encoding mitochondrial ADP/ATP translocator in Saccharomyces cerevisiae by oxygen, heme and ROX1 factor. Adenosine Diphosphate 60-63 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 27-31 27267671-6 2016 Notably, p47 and p37 bind 8-fold more weakly to the ADP-bound conformation of wild-type p97 compared to the ATP-bound conformation. Adenosine Diphosphate 52-55 pleckstrin Homo sapiens 9-12 8392699-3 1993 The ADP removing enzyme system creatine phosphate/creatine phosphokinase (CP/CPK) and the ADP receptor antagonist ATP alpha S strongly inhibited platelet aggregation in response to low doses of TRA, indicating that TRA-induced platelet aggregation, like thrombin-induced aggregation is an ADP mediated event. Adenosine Diphosphate 4-7 T cell receptor alpha locus Homo sapiens 194-197 8392699-3 1993 The ADP removing enzyme system creatine phosphate/creatine phosphokinase (CP/CPK) and the ADP receptor antagonist ATP alpha S strongly inhibited platelet aggregation in response to low doses of TRA, indicating that TRA-induced platelet aggregation, like thrombin-induced aggregation is an ADP mediated event. Adenosine Diphosphate 4-7 T cell receptor alpha locus Homo sapiens 215-218 8420956-8 1993 In the recent crystal structure of RecA-ADP published by Story and Steitz (Story, R.M., and Steitz, T. A. Adenosine Diphosphate 40-43 RAD51 recombinase Homo sapiens 35-39 27236363-1 2016 The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. Adenosine Diphosphate 135-138 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 4-52 27236363-1 2016 The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. Adenosine Diphosphate 135-138 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 54-60 27236363-1 2016 The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. Adenosine Diphosphate 135-138 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 65-69 8420956-10 1993 The fact that we observe no interaction of ATP gamma S with Tyr-103 (as evidenced from absence of fluorescence change) but instead with Tyr-264 may suggest an important conformational difference between the RecA complexes with, respectively, ADP and ATP. Adenosine Diphosphate 242-245 RAD51 recombinase Homo sapiens 207-211 26988592-3 2016 Our recent work identified 2 independent, yet synergistic, signaling pathways that lead to the activation of the small GTPase Rap1; one mediated by the guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), the other by P2Y12, a platelet receptor for adenosine diphosphate and the target of antiplatelet drugs. Adenosine Diphosphate 252-273 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 221-226 1462359-1 1992 Poly(ADP-ribose)polymerase (PARP)-activity was assessed in vitro from the incorporation of the adenosine-diphosphate-ribose moiety of 14C-NAD+ in the acid-insoluble cell fraction. Adenosine Diphosphate 95-116 poly(ADP-ribose) polymerase 1 Gallus gallus 0-26 1462359-1 1992 Poly(ADP-ribose)polymerase (PARP)-activity was assessed in vitro from the incorporation of the adenosine-diphosphate-ribose moiety of 14C-NAD+ in the acid-insoluble cell fraction. Adenosine Diphosphate 95-116 poly(ADP-ribose) polymerase 1 Gallus gallus 28-32 26916296-7 2016 In response to ADP activation, mean PAC-1 binding in platelets from female donors was 17.9+-3.5% vs. 14.0+-4.1% in platelets from male donors, and ESC was significantly greater in platelets from females (p<0.05). Adenosine Diphosphate 15-18 ADCYAP receptor type I Homo sapiens 36-41 1429559-2 1992 Our results indicate that GP85 (CD44) can be photoaffinity labeled by [32P] azido-GTP and [32P]ADP-ribosylated by both PT and CT. Adenosine Diphosphate 95-98 CD44 antigen Mus musculus 32-36 26911685-8 2016 The application of ADP (P2Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the selective P2Y1 receptor antagonist MRS2500. Adenosine Diphosphate 19-22 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 24-28 26911685-8 2016 The application of ADP (P2Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the selective P2Y1 receptor antagonist MRS2500. Adenosine Diphosphate 19-22 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 30-35 26911685-8 2016 The application of ADP (P2Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the selective P2Y1 receptor antagonist MRS2500. Adenosine Diphosphate 19-22 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 41-46 26911685-8 2016 The application of ADP (P2Y1, P2Y12, and P2Y13 agonist) also increased action potential firing, an effect blocked by the selective P2Y1 receptor antagonist MRS2500. Adenosine Diphosphate 19-22 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 131-144 1297346-6 1992 These differences are most probably due to the specificity or number of ADP-ribose groups added to the histones by the endogenous or exogenous poly(ADP-ribose) polymerase. Adenosine Diphosphate 72-75 poly (ADP-ribose) polymerase family, member 1 Mus musculus 143-170 1381311-3 1992 Detailed functional studies revealed that, in contrast to the enterotoxins, both rCTB and mLT lacked ADP-ribosylating and cAMP-stimulating abilities. Adenosine Diphosphate 101-104 phosphate cytidylyltransferase 1B, choline Rattus norvegicus 81-85 26822609-2 2016 We report cryo-electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-type p97 in the presence and absence of an allosteric inhibitor at resolutions of 2.3 and 2.4 angstroms, respectively. Adenosine Diphosphate 60-81 melanotransferrin Homo sapiens 128-131 26822609-2 2016 We report cryo-electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-type p97 in the presence and absence of an allosteric inhibitor at resolutions of 2.3 and 2.4 angstroms, respectively. Adenosine Diphosphate 83-86 melanotransferrin Homo sapiens 128-131 26548633-2 2016 In this regard, we analysed the effect of adenine nucleotide translocase 1 (ANT1), which facilitates the exchange of ADP and ATP across the mitochondrial membrane, on cell-protective survival signalling under hypoxia. Adenosine Diphosphate 117-120 solute carrier family 25 member 4 Homo sapiens 42-74 26548633-2 2016 In this regard, we analysed the effect of adenine nucleotide translocase 1 (ANT1), which facilitates the exchange of ADP and ATP across the mitochondrial membrane, on cell-protective survival signalling under hypoxia. Adenosine Diphosphate 117-120 solute carrier family 25 member 4 Homo sapiens 76-80 26333425-8 2016 P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5"-diphosphate (UDP)] have been shown to have profibrotic effects, as well. Adenosine Diphosphate 25-28 pyrimidinergic receptor P2Y6 Homo sapiens 19-23 26621701-8 2015 In MYBPC3trunc samples, ADP sensitivity highly correlated with cardiac myosin-binding protein-C (cMyBP-C) protein level. Adenosine Diphosphate 24-27 myosin heavy chain 14 Homo sapiens 71-77 26621701-9 2015 Incubation of cardiomyocytes with cMyBP-C antibody against the actin-binding N-terminal region reduced ADP sensitivity, indicative of cMyBP-C"s role in actin-myosin regulation. Adenosine Diphosphate 103-106 myosin heavy chain 14 Homo sapiens 158-164 26621701-12 2015 In conclusion, ADP-stimulated contraction can be used as a tool to study how protein phosphorylation and mutant proteins alter accessibility of myosin binding on actin. Adenosine Diphosphate 15-18 myosin heavy chain 14 Homo sapiens 144-150 1512271-0 1992 K-ras transformation greatly increases the toxin-dependent ADP-ribosylation of GTP binding proteins in thyroid cells. Adenosine Diphosphate 59-62 KRAS proto-oncogene, GTPase Rattus norvegicus 0-5 1512271-9 1992 Rather, the enhanced ADP-ribosylation in K-ras-transformed cells appears to be due to the loss of an inhibitory factor present in the normal cells. Adenosine Diphosphate 21-24 KRAS proto-oncogene, GTPase Rattus norvegicus 41-46 1632782-2 1992 However, ADP-ribosylation of recombinant rhoA expressed in E.coli was not inhibited by these agents. Adenosine Diphosphate 9-12 ras homolog family member A L homeolog Xenopus laevis 41-45 1303144-9 1992 Stimulation with ADP also caused a rapid elevation of platelet [Ca2+]i, but this effect of ADP was different form that of thrombin. Adenosine Diphosphate 17-20 prothrombin Oryctolagus cuniculus 122-130 1544891-0 1992 A GTP-binding protein in rat liver nuclei serving as the specific substrate of pertussis toxin-catalyzed ADP-ribosylation. Adenosine Diphosphate 105-108 RAS like proto-oncogene B Rattus norvegicus 2-21 1518177-6 1992 The anti-GPIIb/IIIa antibody completely inhibited ADP-and collagen-induced platelet aggregation, but no or only mild prolongation of bleeding time was observed. Adenosine Diphosphate 50-53 integrin subunit alpha 2b Homo sapiens 9-14 1731790-1 1992 We present here further evidence supporting that histone H1 contains a nucleotide binding site interacting e.g. with ADP, ATP, GDP and GTP. Adenosine Diphosphate 117-120 H1.0 linker histone Homo sapiens 49-59 1659321-6 1991 Substrate specificity studies show that the relative activity of nucleoside diphosphates (NDP) as phosphate acceptors is in the order of dTDP greater than CDP greater than UDP greater than dUDP greater than GDP greater than or equal to dGDP greater than dCDP greater than dADP greater than ADP; and the relative activity of triphosphate donors is in the order of UTP greater than dTTP greater than CTP greater than dCTP greater than dATP greater than ATP greater than or equal to dGTP greater than GTP. Adenosine Diphosphate 273-276 TAR DNA-binding protein-43 homolog Drosophila melanogaster 137-141 1805448-4 1991 5-HT was less potent at enhancing ADP-induced aggregation in heparinized rat platelet rich plasma (PRP) as compared to citrated PRP. Adenosine Diphosphate 34-37 proline rich protein 2-like 1 Rattus norvegicus 99-102 1907272-4 1991 Fibrinogen, RGDF peptide, and the fibrinogen phi chain decapeptide LGGAKQAGDV inhibited the binding of AC7 to ADP-stimulated platelets. Adenosine Diphosphate 110-113 adenylate cyclase 7 Homo sapiens 103-106 1829527-1 1991 Circular dichroism and HPLC gel filtration were used to show that cytosolic hsp70 is thermally stable but undergoes a conformational transition (midpoint, 43 degrees C; 57 degrees C in the presence of ATP or ADP) leading to oligomerization. Adenosine Diphosphate 208-211 heat shock protein family A (Hsp70) member 4 Homo sapiens 76-81 1829527-3 1991 hsp70 binds ADP more tightly than ATP to form a binary complex, which binds to the unfolded protein more rapidly than free hsp70. Adenosine Diphosphate 12-15 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 1829527-3 1991 hsp70 binds ADP more tightly than ATP to form a binary complex, which binds to the unfolded protein more rapidly than free hsp70. Adenosine Diphosphate 12-15 heat shock protein family A (Hsp70) member 4 Homo sapiens 123-128 1829527-4 1991 ADP also inhibits the ATP-induced dissociation of the hsp70-protein complex. Adenosine Diphosphate 0-3 heat shock protein family A (Hsp70) member 4 Homo sapiens 54-59 1646945-6 1991 Both recombinant GS alpha proteins were sensitive to cholera toxin-catalyzed ADP-ribosylation, although the short form was labeled preferentially in both recombinant and S49 wild-type cell lines. Adenosine Diphosphate 77-80 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 17-25 1902217-7 1991 Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex. Adenosine Diphosphate 30-33 integrin subunit alpha 2b Homo sapiens 285-291 1903353-3 1991 Heparinized platelet-rich plasma (PRP) was more sensitive than citrated PRP to three aggregating agents, ADP, collagen and arachidonic acid. Adenosine Diphosphate 105-108 proline rich protein 2-like 1 Rattus norvegicus 34-37 1903353-5 1991 The ADP-, collagen- and arachidonic acid (0.5-2.0 mM)-induced aggregations of PRP obtained from rats given 1.20% BHT in the diet for 7 days were normal, while arachidonic acid (3.9 mM)-induced aggregation of PRP from BHT-fed rats was significantly lower than control. Adenosine Diphosphate 4-7 proline rich protein 2-like 1 Rattus norvegicus 78-81 1903353-6 1991 PRP from rats given aspirin and warfarin also aggregated normally with ADP or collagen addition. Adenosine Diphosphate 71-74 proline rich protein 2-like 1 Rattus norvegicus 0-3 1993181-9 1991 The amino acid sequence between positions 8 and 37 of salicylate hydroxylase shows homology with known ADP binding sites of other FAD-containing oxidoreductases, thus confirming its biochemical function. Adenosine Diphosphate 103-106 salicylate hydroxylase Pseudomonas putida 54-76 1800620-3 1991 In vitro addition of ferrous sulphate to rat PRP in doses of 2-5 mg/ml significantly decreased platelet aggregation in response to ADP, while collagen-induced aggregation was significantly diminished in presence of the higher doses of ferrous sulphate (4-5 mg/ml). Adenosine Diphosphate 131-134 proline rich protein 2-like 1 Rattus norvegicus 45-48 1899461-3 1991 Both ATP and ADP (0.3-100 microM) caused a concentration-dependent transient peak response of the intracellular free calcium concentration ([Ca2+]i), followed by a lower sustained response. Adenosine Diphosphate 13-16 carbonic anhydrase 2 Homo sapiens 141-144 26014752-6 2015 Patients with concomitant CCB therapy showed significantly higher platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP than patients without CCBs (both P <= 0.03). Adenosine Diphosphate 149-152 selectin P Homo sapiens 98-108 1848931-1 1991 Exogenous guanosine triphosphate (GTP) (1-2 x 10(-4)M) resulted in increased concentrations of cyclic GMP both in endothelium denuded rat mesenteric artery (RMA) and in human ADP-stimulated platelets. Adenosine Diphosphate 175-178 5'-nucleotidase, cytosolic II Homo sapiens 102-105 26014752-7 2015 Moreover, the fold increase of P-selectin and activated GPIIb/IIIa in response to ADP was significantly more pronounced in patients taking CCBs (both P <= 0.03). Adenosine Diphosphate 82-85 selectin P Homo sapiens 31-41 26014752-9 2015 High levels of ADP-inducible P-selectin and activated GPIIb/IIIa were seen significantly more frequent in patients with CCBs than in patients without CCB therapy (both P <= 0.01). Adenosine Diphosphate 15-18 selectin P Homo sapiens 29-39 1660179-3 1991 The additional nuclear coded subunits of the enzyme complexes from higher organisms are involved in the regulation of respiration, as demonstrated by the influence of intraliposomal ATP and ADP on the reconstituted cytochrome c oxidase (COX) from bovine heart. Adenosine Diphosphate 190-193 cytochrome c oxidase subunit 7A1 Bos taurus 237-240 25978521-3 2015 Using AO-alkyne, we show that PARP10 and PARP11 are auto-ADP-ribosylated in cells. Adenosine Diphosphate 57-60 poly(ADP-ribose) polymerase family member 11 Homo sapiens 41-47 1660179-6 1991 Tissue-specific regulation of COX activity is also demonstrated by the differential effects of intraliposomal ADP on the kinetics of reconstituted COX from bovine liver and heart, which differ in subunits VIa, VIIa and VIII. Adenosine Diphosphate 110-113 cytochrome c oxidase subunit 7A1 Bos taurus 30-33 25985179-6 2015 Here we report the first structures of the mammalian PFK1 tetramer, for the human platelet isoform (PFKP), in complex with ATP-Mg(2+) and ADP at 3.1 and 3.4 A, respectively. Adenosine Diphosphate 138-141 phosphofructokinase, muscle Homo sapiens 53-57 1660179-6 1991 Tissue-specific regulation of COX activity is also demonstrated by the differential effects of intraliposomal ADP on the kinetics of reconstituted COX from bovine liver and heart, which differ in subunits VIa, VIIa and VIII. Adenosine Diphosphate 110-113 cytochrome c oxidase subunit 7A1 Bos taurus 147-150 2176621-3 1990 In particular, the precursor of ADP/ATP carrier that is known not to interact with hsp60 on its assembly pathway requires functional mt-hsp70 for import, suggesting a general role of mt-hsp70 in membrane translocation of precursors. Adenosine Diphosphate 32-35 heat shock protein family A (Hsp70) member 4 Homo sapiens 136-141 1980648-3 1990 Among the natural adenine nucleotides, ATP and ADP were able to increase both basal and ANF-stimulated guanylate cyclase activities in rat lung membranes. Adenosine Diphosphate 47-50 natriuretic peptide A Rattus norvegicus 88-91 26056276-5 2015 We used this approach to examine the crucial ADP release step in myosin"s catalytic cycle and detected reversible rotations of two helices in actin-bound myosin in response to ADP binding and dissociation. Adenosine Diphosphate 45-48 myosin heavy chain 14 Homo sapiens 65-71 26056276-5 2015 We used this approach to examine the crucial ADP release step in myosin"s catalytic cycle and detected reversible rotations of two helices in actin-bound myosin in response to ADP binding and dissociation. Adenosine Diphosphate 176-179 myosin heavy chain 14 Homo sapiens 65-71 26028436-4 2015 Using fluorescence microscopy, we show that tropomyosin (non-muscle Drosophila Tm1A) polymerizes along actin filaments, starting from "nuclei" that appear preferentially on ADP-bound regions of the filament, near the pointed end. Adenosine Diphosphate 173-176 Tropomyosin 1 Drosophila melanogaster 44-55 1980648-5 1990 ATP was more effective than AMPPCP (the non-hydrolyzable analog of ATP), and ADP was more effective than ADP beta S and AMPCP (the hydrolysis-resistant analogs of ADP) to increase basal and ANF-stimulated guanylate cyclase activities. Adenosine Diphosphate 77-80 natriuretic peptide A Rattus norvegicus 190-193 2121131-2 1990 These proteins, with molecular masses in the range 18-29 kDa, specifically bind [alpha-32P]GTP, which can be displaced by unlabelled GTP, GDP and their non-hydrolysable analogues guanosine 5"-[delta-thio]triphosphate (GTP[S]) and guanosine 5"-[beta-thio]diphosphate (GDP[S]), but not by GMP, ATP, ADP, AMP and other unrelated nucleotides. Adenosine Diphosphate 297-300 5'-nucleotidase, cytosolic II Homo sapiens 287-290 26058047-4 2015 AA- and ADP-induced P-selectin expression and activated glycoprotein (GP) IIb/IIIa were determined by flow cytometry. Adenosine Diphosphate 8-11 selectin P Homo sapiens 20-30 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 61-82 MAGUK p55 scaffold protein 1 Rattus norvegicus 30-40 25820525-4 2015 Enzymatic clearance is crucial to terminate unnecessary cell activation; one of the most abundantly expressed enzymes on the EC surface is E-NTPDase1/CD39, which hydrolyzes ATP and ADP to AMP. Adenosine Diphosphate 181-184 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 150-154 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 84-87 MAGUK p55 scaffold protein 1 Rattus norvegicus 30-40 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 MAGUK p55 scaffold protein 1 Rattus norvegicus 30-40 25777528-5 2015 KIF5C acquires the "rigor conformation", where mobile switches I and II are stabilized through L11 and the initial portion of the neck-linker, facilitating effective ADP release and the weak-to-strong transition of KIF5C microtubule affinity. Adenosine Diphosphate 166-169 kinesin family member 5C Homo sapiens 0-5 2264020-3 1990 Two of four antibodies, named P9 and P55, strongly inhibited adenosine diphosphate (ADP)-induced aggregation of washed rat platelets and caused approximately 50% inhibition of human fibrinogen binding to ADP-stimulated rat platelets, suggesting that rat GPIIb/IIIa serves as a fibrinogen receptor in ADP-induced aggregation. Adenosine Diphosphate 204-207 MAGUK p55 scaffold protein 1 Rattus norvegicus 30-40 2148682-3 1990 ADP and adenosine 5"-O-(3-thiotriphosphate) (ATP gamma S) inhibit recA protein promoted ATP hydrolysis by fundamentally different mechanisms. Adenosine Diphosphate 0-3 RAD51 recombinase Homo sapiens 66-70 25822790-1 2015 In response to adenosine 5"-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Adenosine Diphosphate 15-39 purinergic receptor P2Y1 Homo sapiens 45-58 2148682-9 1990 The reaction in the presence of poly(deoxythymidylic acid) or duplex DNA ceases when about 60% of the available ATP is hydrolyzed, reflecting an ADP-mediated dissociation of recA protein from the DNA that is governed by the ADP/ATP ratio. Adenosine Diphosphate 145-148 RAD51 recombinase Homo sapiens 174-178 25822790-1 2015 In response to adenosine 5"-diphosphate, the P2Y1 receptor (P2Y1R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug target. Adenosine Diphosphate 15-39 purinergic receptor P2Y1 Homo sapiens 60-65 25681429-5 2015 ADP also induced MCP-1 protein upregulation, which was diminished by R-138727 and P2Y12 siRNAs. Adenosine Diphosphate 0-3 C-C motif chemokine ligand 2 Rattus norvegicus 17-22 25681429-5 2015 ADP also induced MCP-1 protein upregulation, which was diminished by R-138727 and P2Y12 siRNAs. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 82-87 25681429-6 2015 JNK (c-Jun NH2-terminal kinase) inhibition attenuated ADP-induced MCP-1 mRNA and protein upregulation. Adenosine Diphosphate 54-57 mitogen-activated protein kinase 8 Rattus norvegicus 0-3 25681429-6 2015 JNK (c-Jun NH2-terminal kinase) inhibition attenuated ADP-induced MCP-1 mRNA and protein upregulation. Adenosine Diphosphate 54-57 mitogen-activated protein kinase 8 Rattus norvegicus 5-30 25681429-6 2015 JNK (c-Jun NH2-terminal kinase) inhibition attenuated ADP-induced MCP-1 mRNA and protein upregulation. Adenosine Diphosphate 54-57 C-C motif chemokine ligand 2 Rattus norvegicus 66-71 25681429-7 2015 R-138727 and P2Y12 siRNAs inhibited ADP-induced JNK activation. Adenosine Diphosphate 36-39 purinergic receptor P2Y12 Rattus norvegicus 13-18 25681429-7 2015 R-138727 and P2Y12 siRNAs inhibited ADP-induced JNK activation. Adenosine Diphosphate 36-39 mitogen-activated protein kinase 8 Rattus norvegicus 48-51 25681429-8 2015 The reactive oxygen species (ROS) inhibitors N-acetylcysteine (NAC), diphenyleneiodonium (DPI), and Tempol also diminished MCP-1 upregulation and JNK activation induced by ADP. Adenosine Diphosphate 172-175 C-C motif chemokine ligand 2 Rattus norvegicus 123-128 2118762-9 1990 Reconstitution of the platelet membranes ADP-ribosylated by pertussis toxin with Go, not Gi, purified from pig brain restored the thrombin-stimulated release of AA. Adenosine Diphosphate 41-44 prothrombin Oryctolagus cuniculus 130-138 25681429-8 2015 The reactive oxygen species (ROS) inhibitors N-acetylcysteine (NAC), diphenyleneiodonium (DPI), and Tempol also diminished MCP-1 upregulation and JNK activation induced by ADP. Adenosine Diphosphate 172-175 mitogen-activated protein kinase 8 Rattus norvegicus 146-149 25681429-9 2015 ADP induced MCP-1 promoter activation, which was inhibited by R-138727 and P2Y12 siRNAs. Adenosine Diphosphate 0-3 C-C motif chemokine ligand 2 Rattus norvegicus 12-17 25681429-9 2015 ADP induced MCP-1 promoter activation, which was inhibited by R-138727 and P2Y12 siRNAs. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 75-80 25681429-11 2015 ADP-induced NF-kappaB pathway activation, examined by a plasmid containing multiple NF-kappaB sites, was diminished by P2Y12 inhibition. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 119-124 2274928-4 1990 Such proteolytic modification of the GPIIb/IIIa complex was accompanied by a slight increase in the binding of fibrinogen to blood platelets in the absence of ADP. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 37-42 25681429-13 2015 P2Y12 siRNAs and CCR2 antagonism diminished this ADP-induced monocyte adhesion. Adenosine Diphosphate 49-52 purinergic receptor P2Y12 Rattus norvegicus 0-5 2146102-6 1990 Platelet aggregation in response to ADP by PRP was reduced while the rate of disaggregation was increased in platelets from diabetic animals when compared to controls. Adenosine Diphosphate 36-39 proline rich protein 2-like 1 Rattus norvegicus 43-46 2167173-7 1990 TPA inhibited aggregation at greater than or equal to 1 mg.litre-1 with ADP and at greater than or equal to 3.3 mg.litre-1 with collagen as aggregating agent. Adenosine Diphosphate 72-75 chromosome 20 open reading frame 181 Homo sapiens 0-3 2306207-0 1990 ADP evokes biphasic Ca2+ influx in fura-2-loaded human platelets. Adenosine Diphosphate 0-3 carbonic anhydrase 2 Homo sapiens 20-23 2306207-2 1990 Stopped-flow fluorimetric studies at 37 degrees C have shown that ADP, at optimal concentrations, can evoke Ca2+ or Mn2+ influx in fura-2-loaded human platelets without measurable delay. Adenosine Diphosphate 66-69 carbonic anhydrase 2 Homo sapiens 108-111 2306207-3 1990 In contrast, the release of Ca2+ from intracellular stores is delayed in onset by about 200 ms. By working at a lower temperature, 17 degrees C, we have now shown that the rise in cytosolic calcium concentration ([Ca2+]i) evoked by ADP in the presence of external Ca2+ is biphasic. Adenosine Diphosphate 232-235 carbonic anhydrase 2 Homo sapiens 28-31 2306207-3 1990 In contrast, the release of Ca2+ from intracellular stores is delayed in onset by about 200 ms. By working at a lower temperature, 17 degrees C, we have now shown that the rise in cytosolic calcium concentration ([Ca2+]i) evoked by ADP in the presence of external Ca2+ is biphasic. Adenosine Diphosphate 232-235 carbonic anhydrase 2 Homo sapiens 214-217 2306207-3 1990 In contrast, the release of Ca2+ from intracellular stores is delayed in onset by about 200 ms. By working at a lower temperature, 17 degrees C, we have now shown that the rise in cytosolic calcium concentration ([Ca2+]i) evoked by ADP in the presence of external Ca2+ is biphasic. Adenosine Diphosphate 232-235 carbonic anhydrase 2 Homo sapiens 214-217 2306207-5 1990 The fast phase of the ADP-evoked rise in [Ca2+]i, which occurs without measurable delay at both 17 degrees C and 37 degrees C, is consistent with Ca2+ entry mediated by receptor-operated channels in the plasma membrane. Adenosine Diphosphate 22-25 carbonic anhydrase 2 Homo sapiens 42-45 2306207-5 1990 The fast phase of the ADP-evoked rise in [Ca2+]i, which occurs without measurable delay at both 17 degrees C and 37 degrees C, is consistent with Ca2+ entry mediated by receptor-operated channels in the plasma membrane. Adenosine Diphosphate 22-25 carbonic anhydrase 2 Homo sapiens 146-149 2306207-7 1990 Forskolin did not inhibit the fast phases of ADP-evoked rise in [Ca2+]i or Mn2+ quench, but completely abolished ADP-evoked discharge of the intracellular stores, the delayed phase of the rise in [Ca2+]i observed in the presence of external Ca2+ and the second phase of Mn2+ quench. Adenosine Diphosphate 113-116 carbonic anhydrase 2 Homo sapiens 197-200 2306207-7 1990 Forskolin did not inhibit the fast phases of ADP-evoked rise in [Ca2+]i or Mn2+ quench, but completely abolished ADP-evoked discharge of the intracellular stores, the delayed phase of the rise in [Ca2+]i observed in the presence of external Ca2+ and the second phase of Mn2+ quench. Adenosine Diphosphate 113-116 carbonic anhydrase 2 Homo sapiens 197-200 2183912-15 1990 abolished the ET-1-induced inhibition of ADP-stimulated platelet aggregation and significantly potentiated and prolonged the pressor response brought about by ET-1. Adenosine Diphosphate 41-44 endothelin-1 Oryctolagus cuniculus 14-18 2153101-2 1990 Limited treatment of unliganded Rep protein (73 kDa) with trypsin results in cleavage at a single site in its carboxyl-terminal region, producing a 68-kDa polypeptide which is stabilized in the presence of ATP, ADP, or adenosine 5"-O-thiotriphosphate) (ATP gamma S). Adenosine Diphosphate 211-214 replication protein Escherichia coli 32-35 21043948-8 1990 These increases were greater in the presence of fibrinogen and the thrombin-induced increase was smaller than the increase induced by ADP plus reptilase; with ADP plus reptilase, the increase in PIP more than accounted for the loss of extractable PIP(2). Adenosine Diphosphate 159-162 prothrombin Oryctolagus cuniculus 67-75 34934451-6 2022 Denuded, but not native, platelets underwent slow spontaneous aggregation and rapid ADP-mediated GPIIb/IIIa-dependent aggregation according to spectrophotometric assay. Adenosine Diphosphate 84-87 integrin subunit alpha 2b Homo sapiens 97-102 34840926-8 2021 ATP, ADP, UTP, UDP and UDPG also induced osteoclastogenesis as evident from fused multinucleate cells and expression of osteoclast markers (TRAP, Cathepsin K (CTSK)) as determined by Q-PCR. Adenosine Diphosphate 5-8 acid phosphatase 5, tartrate resistant Mus musculus 140-144 34798070-4 2021 Our pull-down and isothermal titration calorimetry (ITC) based studies suggested that HSC70 binds to ARL5B in an ADP-dependent manner. Adenosine Diphosphate 113-116 heat shock protein family A (Hsp70) member 8 Homo sapiens 86-91 34347214-3 2021 AdoMet decreased mitochondrial membrane potential and Ca2+ retention capacity, and these effects were fully prevented by cyclosporin A and ADP, indicating mitochondrial permeability transition (mPT) induction. Adenosine Diphosphate 139-142 methionine adenosyltransferase 1A Rattus norvegicus 0-6 25681429-14 2015 These data suggested that ADP, via the VSMC P2Y12 receptor, induces vascular inflammatory changes by upregulating MCP-1 and promoting monocyte adhesion. Adenosine Diphosphate 26-29 purinergic receptor P2Y12 Rattus norvegicus 44-49 25681429-14 2015 These data suggested that ADP, via the VSMC P2Y12 receptor, induces vascular inflammatory changes by upregulating MCP-1 and promoting monocyte adhesion. Adenosine Diphosphate 26-29 C-C motif chemokine ligand 2 Rattus norvegicus 114-119 25620628-2 2015 hGDH1 is activated by ADP and L-leucine and powerfully inhibited by GTP. Adenosine Diphosphate 22-25 glutamate dehydrogenase 1 Homo sapiens 0-5 25793864-8 2015 Addition of exogenous ADP overcame defective spreading of PLCgamma2-deficient platelets on immobilized fibrinogen, suggesting that PLCgamma2 is required for granule secretion in response to alphaIIbbeta3 ligation. Adenosine Diphosphate 22-25 phospholipase C, gamma 2 Mus musculus 58-67 25793864-8 2015 Addition of exogenous ADP overcame defective spreading of PLCgamma2-deficient platelets on immobilized fibrinogen, suggesting that PLCgamma2 is required for granule secretion in response to alphaIIbbeta3 ligation. Adenosine Diphosphate 22-25 phospholipase C, gamma 2 Mus musculus 131-140 25680381-6 2015 The increase in flux through phosphate dissociation and the unchanged rate of ADP dissociation (AM-ADP AM + ADP) by the drug produce a higher duty ratio motor in which a larger fraction of myosin heads are strongly bound to actin filaments. Adenosine Diphosphate 78-81 myosin heavy chain 14 Homo sapiens 191-197 25593131-2 2015 ADP plays an important role in platelet activation and activates platelets through 2 G-protein-coupled receptors, the Gq-coupled P2Y1 receptor (P2Y1R), and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 129-142 25593131-2 2015 ADP plays an important role in platelet activation and activates platelets through 2 G-protein-coupled receptors, the Gq-coupled P2Y1 receptor (P2Y1R), and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 144-149 26027383-4 2015 From the comparison of K(M) (S0.5) values it follows that hare skeletal muscle PK exhibits a highest affinity to phosphoenol pyruvate, but lowest to ADP, as compared with rabbit skeletal muscle PK. Adenosine Diphosphate 149-152 pyruvate kinase PKLR Oryctolagus cuniculus 79-81 26027383-5 2015 Moreover, PK from both hare tissues exhibits a positive kinetic cooperativity (Hill coefficient > 1.35) of the phosphoenol pyruvate and ADP binding sites. Adenosine Diphosphate 139-142 pyruvate kinase PKLR Oryctolagus cuniculus 10-12 34421595-9 2021 Adenosine diphosphate (ADP), glutamine and guanine levels significantly increased in KKU213 cells while guanine and xanthine levels remarkably increased in KKU055 cells showing a marked difference between the control and FASN knockdown groups. Adenosine Diphosphate 23-26 fatty acid synthase Homo sapiens 221-225 24841338-8 2015 Various P2 receptor subtypes were identified; P2Y1 can bind ADP; P2Y4 is targeted by UTP; and ATP may evoke Ca(2+) transients via detected P2X subtypes, as well as P2Y1 and P2Y2. Adenosine Diphosphate 60-63 purinergic receptor P2Y1 Homo sapiens 46-50 25517169-4 2014 Forces that resist the power stroke slow the myosin-driven contraction by slowing the rate of ADP release, which is the kinetic step that limits fiber shortening. Adenosine Diphosphate 94-97 myosin heavy chain 14 Homo sapiens 45-51 34261790-3 2021 Here, using a comprehensive set of structural, biophysical, and cell biological tools, we have uncovered a CL-binding motif (CBM) conserved between the Drp1 variable domain (VD) and the unrelated ADP/ATP carrier (AAC/ANT) that intercalates into the membrane core to effect specific CL interactions. Adenosine Diphosphate 196-199 glycine-N-acyltransferase Homo sapiens 213-216 34201069-4 2021 Therefore, inhibition of poly(adenosine diphosphate (ADP)-ribose) polymerase (PARP) has the potential to increase PDT efficacy. Adenosine Diphosphate 53-56 poly (ADP-ribose) polymerase family, member 1 Mus musculus 78-82 25392530-3 2014 We previously reported that ADP-ribosyl-arginine is converted nonenzymatically to ornithine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were isolated from bronchoalveolar lavage fluid of a patient with idiopathic pulmonary fibrosis, indicating that these reactions occur in vivo. Adenosine Diphosphate 28-31 HNP1 Homo sapiens 117-122 25208846-3 2014 Here, we demonstrate, using myography, that ADP and ADPbetaS dose-dependently induce mouse BSM contraction, and ADP-induced BSM contraction is blocked by a selective P2Y12 receptor (P2Y12R) antagonist, PSB 0739 (25 muM), but is unaffected by P2Y1 and P2Y13 receptor antagonists. Adenosine Diphosphate 44-47 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 166-170 35622909-1 2022 The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (Mac1) removes adenosine diphosphate (ADP) ribosylation posttranslational modifications, playing a key role in the immune evasion capabilities of the virus responsible for the coronavirus disease 2019 pandemic. Adenosine Diphosphate 149-152 integrin subunit alpha M Homo sapiens 112-116 25272186-4 2014 CD39 is an ectonucleotidase that degrades ATP to ADP and AMP. Adenosine Diphosphate 49-52 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 35628475-5 2022 Our results show the presence of azurocidin mRNA and protein in alpha-granules of platelet and megakaryoblasts, and stimulation with thrombin, ADP, and LPS leads to the secretion of free azurocidin as well as within extracellular vesicles. Adenosine Diphosphate 143-146 azurocidin 1 Homo sapiens 33-43 24819348-1 2014 Adenine nucleotide translocase (ANT) isoforms are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in the cytosol. Adenosine Diphosphate 164-167 solute carrier family 25 member 6 Homo sapiens 0-30 35628475-5 2022 Our results show the presence of azurocidin mRNA and protein in alpha-granules of platelet and megakaryoblasts, and stimulation with thrombin, ADP, and LPS leads to the secretion of free azurocidin as well as within extracellular vesicles. Adenosine Diphosphate 143-146 azurocidin 1 Homo sapiens 187-197 24819348-1 2014 Adenine nucleotide translocase (ANT) isoforms are mitochondrial proteins encoded by nuclear DNA that catalyze the exchange of ATP generated in the mitochondria for ADP produced in the cytosol. Adenosine Diphosphate 164-167 solute carrier family 25 member 6 Homo sapiens 32-35 35521544-6 2022 Identification of the new site unveils the unusually high substrate specificity of AAC and explains the dependence of transport on the flexibility between anti and syn glycosidic conformers of ADP. Adenosine Diphosphate 193-196 synemin Homo sapiens 164-167 35294260-6 2022 In vitro, P2X7R+ CD8 T cells were susceptible to ART1-mediated ADP-ribosylation and NICD, which was exacerbated upon blockade of the NAD+-degrading ADP-ribosyl cyclase CD38. Adenosine Diphosphate 63-66 CD8a molecule Homo sapiens 17-20 25229666-4 2014 Mitochondrial DeltaPsi then drives the release of ATP(4-) from the matrix in exchange for ADP(3-) in the cytosol via the adenine nucleotide translocator (ANT) located in the mitochondrial inner membrane. Adenosine Diphosphate 90-93 solute carrier family 25 member 6 Homo sapiens 121-152 35329930-10 2022 After revising the Dffm estimates, agreement between ADP and DXA improved, with mean differences (LoA) for FM, FM%, and FFM of -0.67 kg (-2.38; 1.04), -3.54% (-13.44; 6.36), and 0.5 kg (-1.30; 2.30), respectively, but a small fixed and proportional bias remained. Adenosine Diphosphate 53-56 fibromodulin Homo sapiens 107-109 25229666-4 2014 Mitochondrial DeltaPsi then drives the release of ATP(4-) from the matrix in exchange for ADP(3-) in the cytosol via the adenine nucleotide translocator (ANT) located in the mitochondrial inner membrane. Adenosine Diphosphate 90-93 solute carrier family 25 member 6 Homo sapiens 154-157 35329930-10 2022 After revising the Dffm estimates, agreement between ADP and DXA improved, with mean differences (LoA) for FM, FM%, and FFM of -0.67 kg (-2.38; 1.04), -3.54% (-13.44; 6.36), and 0.5 kg (-1.30; 2.30), respectively, but a small fixed and proportional bias remained. Adenosine Diphosphate 53-56 fibromodulin Homo sapiens 111-113 25265574-4 2014 These data suggest that low concentrations of C1C2 and C0C2 activate thin filaments by a mechanism similar to that of rigor myosin-S1, whereas higher concentrations inhibit the ATPase rate by competing with myosin-S1-ADP-Pi for binding to actin and thin filaments. Adenosine Diphosphate 216-220 myosin heavy chain 14 Homo sapiens 207-213 25373779-4 2014 In contrast to other isoforms, cofilin-2 efficiently binds and disassembles both ADP- and ATP/ADP-Pi-actin filaments. Adenosine Diphosphate 81-84 cofilin 2 Homo sapiens 31-40 25373779-4 2014 In contrast to other isoforms, cofilin-2 efficiently binds and disassembles both ADP- and ATP/ADP-Pi-actin filaments. Adenosine Diphosphate 94-97 cofilin 2 Homo sapiens 31-40 25373779-6 2014 The results suggest that cofilin-2 evolved specific biochemical and cellular properties that allow it to control actin dynamics in sarcomeres, where filament pointed ends may contain a mixture of ADP- and ATP/ADP-Pi-actin subunits. Adenosine Diphosphate 196-199 cofilin 2 Homo sapiens 25-34 25373779-6 2014 The results suggest that cofilin-2 evolved specific biochemical and cellular properties that allow it to control actin dynamics in sarcomeres, where filament pointed ends may contain a mixture of ADP- and ATP/ADP-Pi-actin subunits. Adenosine Diphosphate 209-212 cofilin 2 Homo sapiens 25-34 35109669-2 2022 CK (creatine kinase), the primary muscle energy reserve reaction which rapidly provides ATP at the myofibrils and regenerates mitochondrial ADP, is down-regulated in experimental and human HF. Adenosine Diphosphate 140-143 cytidine/uridine monophosphate kinase 1 Homo sapiens 0-2 24923466-0 2014 Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation. Adenosine Diphosphate 85-88 purinergic receptor P2X 1 Homo sapiens 20-24 24923466-2 2014 For example, during hemostasis and thrombosis, ATP-gated P2X1 channels and ADP-stimulated P2Y1 and P2Y12 G-protein coupled receptors play important roles in platelet activation. Adenosine Diphosphate 75-78 purinergic receptor P2Y1 Homo sapiens 90-94 24923466-4 2014 In human platelets, we show that maximally activated P2X1 receptors failed to stimulate significant aggregation but could amplify the aggregation response to a submaximal concentration of ADP. Adenosine Diphosphate 188-191 purinergic receptor P2X 1 Homo sapiens 53-57 24923466-6 2014 The potentiation, due to an enhanced P2Y1 response, was observed if ADP was added up to 60 seconds after P2X1 activation. Adenosine Diphosphate 68-71 purinergic receptor P2Y1 Homo sapiens 37-41 35109669-2 2022 CK (creatine kinase), the primary muscle energy reserve reaction which rapidly provides ATP at the myofibrils and regenerates mitochondrial ADP, is down-regulated in experimental and human HF. Adenosine Diphosphate 140-143 cytidine/uridine monophosphate kinase 1 Homo sapiens 4-19 24923466-6 2014 The potentiation, due to an enhanced P2Y1 response, was observed if ADP was added up to 60 seconds after P2X1 activation. Adenosine Diphosphate 68-71 purinergic receptor P2X 1 Homo sapiens 105-109 35262075-6 2022 We identified 5 compounds amongst 3 chemotypes that inhibit SARS-CoV-2 Mac1-ADP-ribose binding in multiple assays with IC 50 values less than 100 micro M, inhibit ADP-ribosylhydrolase activity, and have evidence of direct Mac1 binding. Adenosine Diphosphate 76-79 integrin subunit alpha M Homo sapiens 71-75 25006251-0 2014 Magnesium modulates actin binding and ADP release in myosin motors. Adenosine Diphosphate 38-41 myosin heavy chain 14 Homo sapiens 53-59 35262075-6 2022 We identified 5 compounds amongst 3 chemotypes that inhibit SARS-CoV-2 Mac1-ADP-ribose binding in multiple assays with IC 50 values less than 100 micro M, inhibit ADP-ribosylhydrolase activity, and have evidence of direct Mac1 binding. Adenosine Diphosphate 76-79 integrin subunit alpha M Homo sapiens 222-226 25006251-3 2014 We found that the ADP release rate constant is reduced by Mg(2+) in myosin V, smooth muscle myosin, nonmuscle myosin IIA, CMIIB, and DdMII, although the ADP affinity is fairly insensitive to Mg(2+) in fast skeletal muscle myosin, CMIIB, and DdMII. Adenosine Diphosphate 18-21 myosin heavy chain 14 Homo sapiens 68-74 25006251-3 2014 We found that the ADP release rate constant is reduced by Mg(2+) in myosin V, smooth muscle myosin, nonmuscle myosin IIA, CMIIB, and DdMII, although the ADP affinity is fairly insensitive to Mg(2+) in fast skeletal muscle myosin, CMIIB, and DdMII. Adenosine Diphosphate 18-21 myosin heavy chain 14 Homo sapiens 92-98 2674130-11 1989 Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin. Adenosine Diphosphate 91-94 Rac family small GTPase 1 Homo sapiens 58-62 2693515-2 1989 A 20 min in vitro assay, in which a radioactive ADP-ribosyl residue is transferred specifically and 1:1 stoichiometrically to EF-2, is sufficient to estimate the total amounts of ADP-ribosylatable active EF-2. Adenosine Diphosphate 48-51 immunoglobulin kappa variable 1-27 Homo sapiens 0-4 2693515-2 1989 A 20 min in vitro assay, in which a radioactive ADP-ribosyl residue is transferred specifically and 1:1 stoichiometrically to EF-2, is sufficient to estimate the total amounts of ADP-ribosylatable active EF-2. Adenosine Diphosphate 179-182 immunoglobulin kappa variable 1-27 Homo sapiens 0-4 2551688-2 1989 This paper describes a large-scale purification of guanylate kinase (ATP + GMP in equilibrium ADP + GDP) from Saccharomyces cerevisiae, the crystallization of the enzyme and preliminary X-ray investigations. Adenosine Diphosphate 94-97 guanylate kinase Saccharomyces cerevisiae S288C 51-67 24884163-6 2014 Of the acetylated proteins, ANT1, which catalyzes ADP-ATP exchange across the inner mitochondrial membrane, was acetylated at lysines 10, 23, and 92. Adenosine Diphosphate 50-53 solute carrier family 25 member 4 Homo sapiens 28-32 24884163-8 2014 Molecular dynamics modeling and ensemble docking simulations predicted the ADP binding site of ANT1 to be a pocket of positively charged residues, including lysine 23. Adenosine Diphosphate 75-78 solute carrier family 25 member 4 Homo sapiens 95-99 24884163-11 2014 Therefore, acetylation of ANT1 could have dramatic physiological effects on ADP-ATP exchange. Adenosine Diphosphate 76-79 solute carrier family 25 member 4 Homo sapiens 26-30 2745443-5 1989 The association of CD9 with the GPIIb-IIIa complex is unaffected by a combination of aspirin and ADP scavengers sufficient to abrogate anti-CD9 monoclonal antibody-induced platelet aggregation, and is therefore not dependent upon thromboxane- and ADP-mediated pathways of intracellular signalling. Adenosine Diphosphate 247-250 CD9 molecule Homo sapiens 19-22 24488929-3 2014 In this study, we provide evidence that Tat interacts with Eg5, a microtubule-associated motor protein, and allosterically modulates the ATPase activity of Eg5 by affecting ADP release from the enzyme"s active centre. Adenosine Diphosphate 173-176 kinesin family member 11 Homo sapiens 59-62 24488929-3 2014 In this study, we provide evidence that Tat interacts with Eg5, a microtubule-associated motor protein, and allosterically modulates the ATPase activity of Eg5 by affecting ADP release from the enzyme"s active centre. Adenosine Diphosphate 173-176 kinesin family member 11 Homo sapiens 156-159 2524489-8 1989 The extinction coefficient of purified E. coli Rep protein is epsilon 280 = 1.16 +/- 0.04 ml mg-1 cm-1 (8.47 +/- 0.28 X 10(4) M-1 cm-1) in 10 mM Tris (pH 7.5), 20% (v/v) glycerol, 0.10 M NaCl at 25 degrees C. The solubility properties of the purified Rep protein have been examined as a function of glycerol, NaCl, MgCl2, ATP, and ADP concentrations at 25 and 37 degrees C (pH 7.5). Adenosine Diphosphate 331-334 replication protein Escherichia coli 47-50 24809456-3 2014 Steady-state ATPase activity and ADP dissociation kinetics demonstrated that a dimer of Myo5c-HMM (double-headed heavy meromyosin 5c) has a 6-fold lower Km for actin filaments than Myo5c-S1 (single-headed myosin 5c subfragment-1), indicating that the two heads of Myo5c-HMM increase F-actin-binding affinity. Adenosine Diphosphate 33-36 myosin VC Homo sapiens 88-93 24809456-3 2014 Steady-state ATPase activity and ADP dissociation kinetics demonstrated that a dimer of Myo5c-HMM (double-headed heavy meromyosin 5c) has a 6-fold lower Km for actin filaments than Myo5c-S1 (single-headed myosin 5c subfragment-1), indicating that the two heads of Myo5c-HMM increase F-actin-binding affinity. Adenosine Diphosphate 33-36 myosin VC Homo sapiens 123-132 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 36-39 ribosomal protein S6 kinase B1 Homo sapiens 127-133 24612393-8 2014 PKC-mediated adenosine diphosphate (ADP) secretion was essential for thrombin-stimulated mTORC1 activation, as (i) ADP rescued p70S6K phosphorylation in the presence of a PKC inhibitor and (ii) P2Y(12) antagonism prevented thrombin-mediated mTORC1 activation. Adenosine Diphosphate 115-118 ribosomal protein S6 kinase B1 Homo sapiens 127-133 24642865-4 2014 The P-selectin and activated gpIIb/IIIa expression on platelet membranes in response to ADP, collagen and thrombin stimulation was measured at various hematocrit and oxygen levels. Adenosine Diphosphate 88-91 selectin P Homo sapiens 4-14 24550450-9 2014 We performed a screen for P2Y1 receptor-mediated receptor tyrosine kinase transactivation and discovered that ADP transactivates Fms-like tyrosine kinase 3 (Flt3), a receptor tyrosine kinase expressed in these cells. Adenosine Diphosphate 110-113 purinergic receptor P2Y1 Homo sapiens 26-39 2524489-9 1989 Rep protein solubility decreases significantly with decreasing concentrations of glycerol and monovalent salt and increasing temperature; however, the presence of 1.5 mM ATP or ADP or MgCl2 at low NaCl concentrations increases the solubility. Adenosine Diphosphate 177-180 replication protein Escherichia coli 0-3 2655616-7 1989 In isolated plasma membranes of pancreatic acinar cells a 40 kDa protein was adenosine diphosphate (ADP)-ribosylated by CT, which was inhibited by CCK-OP but not by Cch. Adenosine Diphosphate 77-98 cholecystokinin Rattus norvegicus 147-150 24528675-5 2014 On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT). Adenosine Diphosphate 80-83 purple acid phosphatase 12 Arabidopsis thaliana 182-189 24528675-6 2014 Overexpression of the AtPAP12 or AtPAP26 gene, however, caused plants to grow better on P- or P- medium supplemented with ADP or Fru-6-P. Adenosine Diphosphate 122-125 purple acid phosphatase 12 Arabidopsis thaliana 22-29 2655616-7 1989 In isolated plasma membranes of pancreatic acinar cells a 40 kDa protein was adenosine diphosphate (ADP)-ribosylated by CT, which was inhibited by CCK-OP but not by Cch. Adenosine Diphosphate 100-103 cholecystokinin Rattus norvegicus 147-150 2473289-3 1989 ET-1 inhibited ADP-induced platelet aggregation by 83 +/- 9% within 5 min (p less than 0.01). Adenosine Diphosphate 15-18 endothelin-1 Oryctolagus cuniculus 0-4 24584741-6 2014 Platelet responses to adenosine diphosphate (ADP) and prostacyclin (PGI2) were measured by flow cytometric analysis of platelet fibrinogen binding and P-selectin expression using whole blood taken during each infusion (at 2 hours) and at the end of each clamp. Adenosine Diphosphate 22-43 selectin P Homo sapiens 151-161 3049815-2 1988 It has been shown previously that CD11b/CD18 on cells of monocyte and myeloid lineage appears to undergo rapid activation and acquire new functional receptor specificities after exposure to selected agonists such as adenosine diphosphate (ADP). Adenosine Diphosphate 216-237 integrin subunit alpha M Homo sapiens 34-39 24304835-6 2014 Isolated mitochondria from AMPKgamma3(R200Q) muscle had greater maximal, ADP-stimulated oxygen consumption rate. Adenosine Diphosphate 73-76 protein kinase AMP-activated non-catalytic subunit gamma 3 Sus scrofa 27-37 3049815-2 1988 It has been shown previously that CD11b/CD18 on cells of monocyte and myeloid lineage appears to undergo rapid activation and acquire new functional receptor specificities after exposure to selected agonists such as adenosine diphosphate (ADP). Adenosine Diphosphate 239-242 integrin subunit alpha M Homo sapiens 34-39 3049815-3 1988 We now show that ADP induces a reconformation of the CD11b/CD18 receptor with exposure of new epitopes characteristics of this activated state. Adenosine Diphosphate 17-20 integrin subunit alpha M Homo sapiens 53-58 3049815-4 1988 By direct binding studies, flow cytometry, and immunoprecipitation experiments, it has been found that the mAb 7E3 reacts with CD11b/CD18 only after ADP-stimulation of the cell suspension. Adenosine Diphosphate 149-152 integrin subunit alpha M Homo sapiens 127-132 3049815-5 1988 The activated state of CD11b/CD18 induced by ADP and recognized by 7E3 can also be recapitulated by agonists inducing transients in cytosolic Ca2+ such as the chemoattractant FMLP. Adenosine Diphosphate 45-48 integrin subunit alpha M Homo sapiens 23-28 3049815-7 1988 Because 7E3 also recognizes a qualitative, ADP-mediated activated state of the platelet adhesion receptor GP IIb/IIIa, it is suggested that transients in cytosolic Ca2+ might represent early secondary events for a general pathway of rapid activation of integrin receptors and, as such, represent important signals for cellular interactions in the immune response. Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 106-112 24428678-6 2014 EDACS was combined with electrocardiogram results and troponin results at 0 and 2 h to develop an ADP (EDACS-ADP). Adenosine Diphosphate 98-101 WD and tetratricopeptide repeats 1 Homo sapiens 103-112 2457581-17 1988 Both the ecto-ATPase and the (Ca2+-Mg2+)-ATPase have broad nucleotide-hydrolyzing activity, i.e. they both hydrolyze ATP, GTP, UTP, CTP, ADP, and GDP to a similar extent. Adenosine Diphosphate 137-140 CEA cell adhesion molecule 1 Rattus norvegicus 9-20 2457581-20 1988 These properties indicate that the previously purified (Ca2+-Mg2+)-ATPase is an ecto-ATPase and may function in regulating the effect of ATP and ADP on hepatocyte Ca2+ mobilization (Charest, R., Blackmore, P.F., and Exton, J.H. Adenosine Diphosphate 145-148 CEA cell adhesion molecule 1 Rattus norvegicus 80-91 3141627-3 1988 Addition of bovine serum albumin (BSA) to the mitochondria, isolated in BSA-free media, abolished an ischemia-induced increase in substrate-stimulated (state 4) respiration but only partly reversed a marked inhibition of substrate-, phosphate-, and ADP-stimulated (state 3) respiration caused by the ischemia. Adenosine Diphosphate 249-252 albumin Rattus norvegicus 19-32 24367975-8 2014 Like Ded1p, Mss116p forms long-lived complexes with ADP-AlFx, but Sub2p does not. Adenosine Diphosphate 52-55 DEAD-box ATP-dependent RNA helicase DED1 Saccharomyces cerevisiae S288C 5-10 24367975-8 2014 Like Ded1p, Mss116p forms long-lived complexes with ADP-AlFx, but Sub2p does not. Adenosine Diphosphate 52-55 ATP-dependent RNA helicase Saccharomyces cerevisiae S288C 12-19 24196964-4 2013 Here, we show that within the hexameric ring of a mutant p97, D1 domains fail to regulate their respective nucleotide-binding states, as evidenced by the lower amount of prebound ADP, weaker ADP binding affinity, full occupancy of adenosine-5"-O-(3-thiotriphosphate) binding, and elevated overall ATPase activity, indicating a loss of communication among subunits. Adenosine Diphosphate 179-182 melanotransferrin Homo sapiens 57-60 24196964-4 2013 Here, we show that within the hexameric ring of a mutant p97, D1 domains fail to regulate their respective nucleotide-binding states, as evidenced by the lower amount of prebound ADP, weaker ADP binding affinity, full occupancy of adenosine-5"-O-(3-thiotriphosphate) binding, and elevated overall ATPase activity, indicating a loss of communication among subunits. Adenosine Diphosphate 191-194 melanotransferrin Homo sapiens 57-60 23806663-11 2013 We then exploited a FRET biosensor for PIP3 to show that the striking ADP-dependent increase in intracellular PIP3 is entirely blocked by PTEN knockdown. Adenosine Diphosphate 70-73 phosphatase and tensin homolog Homo sapiens 138-142 23901069-1 2013 The ectoenzyme CD39 suppresses thrombosis and inflammation by suppressing ATP and ADP to AMP. Adenosine Diphosphate 82-85 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 15-19 3291978-3 1988 Only KRDS (900 mumol/L) inhibited the binding of AP2 and P2 on ADP (5 mumol/L)-stimulated platelets, but not on unstimulated platelets. Adenosine Diphosphate 63-66 transcription factor AP-2 alpha Homo sapiens 49-52 3291978-5 1988 Radiolabeled AP2 binding was inhibited by 30% with KRDS on ADP-stimulated platelets as compared with platelets incubated in the absence of ADP. Adenosine Diphosphate 59-62 transcription factor AP-2 alpha Homo sapiens 13-16 3291978-5 1988 Radiolabeled AP2 binding was inhibited by 30% with KRDS on ADP-stimulated platelets as compared with platelets incubated in the absence of ADP. Adenosine Diphosphate 139-142 transcription factor AP-2 alpha Homo sapiens 13-16 23512946-8 2013 CONCLUSION: Consistent with animal studies, our results suggest that high adp expression in human adipose tissue is associated with lower adiposity and enhanced glucose utilization. Adenosine Diphosphate 74-77 WD and tetratricopeptide repeats 1 Mus musculus 98-105 2454858-5 1988 The channels are also closed by the metabolism of the major insulin secretagogues, glucose and the amino acids, which signal insulin release by increasing the ATP level or the [ATP]-to-[ADP] ratio on the cytoplasmic side of the channel. Adenosine Diphosphate 186-189 Insulin-like receptor Drosophila melanogaster 60-67 23896409-0 2013 Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism. Adenosine Diphosphate 85-88 fermitin family member 2 Mus musculus 0-9 23896409-5 2013 Cell-surface expression of 2 enzymes involved in ADP/adenosine 5"-monophosphate (AMP) degradation, adenosine triphosphate (ATP) diphosphohydrolase (CD39) and ecto-5"-nucleotidase (CD73) were increased twofold to threefold on kindlin-2(+/-) ECs, leading to enhanced ATP/ADP catabolism and production of adenosine, an inhibitor of platelet aggregation. Adenosine Diphosphate 269-272 5' nucleotidase, ecto Mus musculus 158-178 2454858-5 1988 The channels are also closed by the metabolism of the major insulin secretagogues, glucose and the amino acids, which signal insulin release by increasing the ATP level or the [ATP]-to-[ADP] ratio on the cytoplasmic side of the channel. Adenosine Diphosphate 186-189 Insulin-like receptor Drosophila melanogaster 125-132 2834388-6 1988 However, an AAC-DHFR gene fusion containing the first 111 residues of the ADP/ATP carrier protein exhibited binding to mitochondria at low temperature (2 degrees C) and internalization at 25 degrees C to a mitochondrial space protected from proteinase K in the same manner as the wild-type ADP/ATP carrier protein. Adenosine Diphosphate 74-77 dihydrofolate reductase Mus musculus 16-20 23908353-6 2013 The results of kinetic analysis show that among the closely related adult skeletal isoforms, the affinity of ADP for actin myosin (K(AD)) is the characteristic that most readily distinguishes the isoforms. Adenosine Diphosphate 109-112 myosin heavy chain 14 Homo sapiens 123-129 2834388-6 1988 However, an AAC-DHFR gene fusion containing the first 111 residues of the ADP/ATP carrier protein exhibited binding to mitochondria at low temperature (2 degrees C) and internalization at 25 degrees C to a mitochondrial space protected from proteinase K in the same manner as the wild-type ADP/ATP carrier protein. Adenosine Diphosphate 290-293 dihydrofolate reductase Mus musculus 16-20 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 64-67 suppressor of cytokine signaling 7 Homo sapiens 59-63 23966629-7 2013 We provide evidence that IL-7 exerts a synergistic effect through downmodulation of the ectoenzyme CD39, which converts ATP to ADP/AMP, and an increase in ATP receptor P2X7. Adenosine Diphosphate 127-130 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 99-103 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 64-67 suppressor of cytokine signaling 7 Homo sapiens 115-119 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 64-67 suppressor of cytokine signaling 7 Homo sapiens 115-119 23788140-3 2013 Using platelet-specific PDI-deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adenosine triphosphate secretion induced by thrombin, collagen, and adenosine diphosphate. Adenosine Diphosphate 183-204 prolyl 4-hydroxylase, beta polypeptide Mus musculus 64-67 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 120-123 suppressor of cytokine signaling 7 Homo sapiens 59-63 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 136-141 23812373-3 2013 Hip is thought to delay substrate release by slowing ADP dissociation from Hsp70. Adenosine Diphosphate 53-56 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 75-80 3584243-7 1987 To determine whether the receptors clustered before ligand binding, or as a consequence thereof, we studied the surface distribution of GPIIb-IIIa after stimulation with ADP, which causes activation of the fibrinogen receptor function of GPIIb-IIIa without inducing the release of fibrinogen. Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 238-243 23812373-5 2013 As shown in a cocrystal structure, the TPR core of Hip interacts with the Hsp70 ATPase domain through an extensive interface, to form a bracket that locks ADP in the binding cleft. Adenosine Diphosphate 155-158 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 74-79 3801462-6 1987 A diffusion rate constant of (8.7 +/- 4.7) 10(4) microliters X mg-1 X min-1 for ADP and ATP was estimated, resulting in rate-dependent concentration differences up to 13.7 microM AdN between the extramitochondrial space and the AdN-translocator at the maximum rate of oxidative phosphorylation of rat-heart mitochondria. Adenosine Diphosphate 80-83 complement factor D Rattus norvegicus 179-182 3801462-6 1987 A diffusion rate constant of (8.7 +/- 4.7) 10(4) microliters X mg-1 X min-1 for ADP and ATP was estimated, resulting in rate-dependent concentration differences up to 13.7 microM AdN between the extramitochondrial space and the AdN-translocator at the maximum rate of oxidative phosphorylation of rat-heart mitochondria. Adenosine Diphosphate 80-83 complement factor D Rattus norvegicus 228-231 23751065-10 2013 When ATP is placed in the ADP-bound conformation of Eg5, the ATP-Mg moiety is surrounded by many water molecules and Thr107 blocks the water chain, which together make the hydrolysis reaction less favorable. Adenosine Diphosphate 26-29 kinesin family member 11 Homo sapiens 52-55 3801462-7 1987 The results support the assumption that ADP diffusion towards the AdN-translocator is limited if its extramitochondrial concentration is low, resulting in a dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space. Adenosine Diphosphate 40-43 complement factor D Rattus norvegicus 66-69 3098603-10 1987 The target of the IAP effect on intact sperm appears to be at the level of the Gi-like protein since IAP-catalyzed 32P-ADP-ribosylation of the Mr = 41,000 substrate in detergent extracts of sperm is reduced when intact sperm are preincubated with IAP during capacitation. Adenosine Diphosphate 119-122 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 18-21 3098603-10 1987 The target of the IAP effect on intact sperm appears to be at the level of the Gi-like protein since IAP-catalyzed 32P-ADP-ribosylation of the Mr = 41,000 substrate in detergent extracts of sperm is reduced when intact sperm are preincubated with IAP during capacitation. Adenosine Diphosphate 119-122 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 101-104 3098603-10 1987 The target of the IAP effect on intact sperm appears to be at the level of the Gi-like protein since IAP-catalyzed 32P-ADP-ribosylation of the Mr = 41,000 substrate in detergent extracts of sperm is reduced when intact sperm are preincubated with IAP during capacitation. Adenosine Diphosphate 119-122 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 101-104 3086310-1 1986 Identification by islet-activating protein-catalyzed ADP-ribosylation and immunochemical methods. Adenosine Diphosphate 53-56 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 18-42 3733317-2 1986 Substrate binding studies and the incorporation of the complete amino acid sequence of horse-muscle PGK into its X-ray model suggest that the C-domain is an ADP/ATP binding unit and that the N-terminal domain contains the phosphoglycerate binding site and the active site located in a prominent cluster of positively charged residues. Adenosine Diphosphate 157-160 phosphoglycerate kinase 1 Equus caballus 100-103 3950576-9 1986 Assuming that under normal substrate conditions the reaction cycle of the Na/K pump is rate-limited by the conformational change associated with the release of occluded K [E2 X (K) X ATP----E1 X ATP + K], increasing ADP inhibits the rate of these transformations by competition with ATP for the E2(K) form. Adenosine Diphosphate 216-219 dihydrolipoamide S-succinyltransferase Homo sapiens 295-300 2984300-6 1985 The number of antigenic sites for monoclonal antibody reacting with GPIIb/GPIIIa complex of adenosine diphosphate-stimulated platelets decreased from 34,200 +/- 5,940 to 19,500 +/- 9,680/platelet after recirculation (P less than or equal to 0.025). Adenosine Diphosphate 92-113 integrin subunit alpha 2b Homo sapiens 68-73 3921021-0 1985 Effects of pertussis toxin-catalyzed ADP-ribosylation on interactions of transducin and the inhibitory GTP-binding protein of adenylate cyclase with guanyl nucleotides. Adenosine Diphosphate 37-40 guanine nucleotide binding protein, alpha transducing 1 Mus musculus 73-83 3981638-4 1985 It is shown that ATP, AMP-P-N-P and, in particular, ATP-gamma-S significantly increase the affinity of recA protein for single-stranded DNA, whereas ADP and, to a lesser degree, AMP-P-C-P decrease the affinity. Adenosine Diphosphate 149-152 RAD51 recombinase Homo sapiens 103-107 3981638-6 1985 The effect that ADP has on recA protein-DNA affinity is to lower the intrinsic binding constant, but it has no effect on the co-operativity of binding. Adenosine Diphosphate 16-19 RAD51 recombinase Homo sapiens 27-31 3981638-10 1985 The modulation of recA protein-DNA complex stability by nucleotide cofactors suggests that these cofactors play a role in the cycling of recA protein on and off single-stranded DNA, with ATP being required for DNA binding under physiological conditions and ADP serving as a "release" factor. Adenosine Diphosphate 257-260 RAD51 recombinase Homo sapiens 18-22 3981638-10 1985 The modulation of recA protein-DNA complex stability by nucleotide cofactors suggests that these cofactors play a role in the cycling of recA protein on and off single-stranded DNA, with ATP being required for DNA binding under physiological conditions and ADP serving as a "release" factor. Adenosine Diphosphate 257-260 RAD51 recombinase Homo sapiens 137-141 2937465-8 1985 Finally, a rapid and complete inhibition of platelet aggregation to ADP was observed from 5000 sec-1. Adenosine Diphosphate 68-71 secretory blood group 1, pseudogene Homo sapiens 95-100 6522106-6 1984 ADP associated with thrombin failed to trigger formation of microthrombi but initiated platelet-rich thrombi in the pulmonary vasculature when associated with norepinephrine. Adenosine Diphosphate 0-3 prothrombin Oryctolagus cuniculus 20-28 6506030-3 1984 ADP-induced platelet aggregates grew in size and tended to sediment as shear rate decreased, in particular, below 10 sec-1. Adenosine Diphosphate 0-3 secretory blood group 1, pseudogene Homo sapiens 117-122 6714369-4 1984 Aggregation by thrombin was not affected by the methylation inhibitors even when ADP was scavenged and thromboxane formation was suppressed. Adenosine Diphosphate 81-84 prothrombin Oryctolagus cuniculus 15-23 6230229-9 1984 Omission of photoactivation, platelets, or ADP from the reaction or use of unmodified 125I-Fg resulted in less than 5% immunoprecipitation by the anti-GP IIb/III. Adenosine Diphosphate 43-46 integrin subunit alpha 2b Homo sapiens 151-157 6320805-7 1984 The dye appears to act as an affinity label for the ATP/ADP-binding site by preferentially arylating a thiol residue generated during the reductive activation of the enzyme that is achieved by dithiothreitol or thioredoxin in vitro or during illumination of leaves. Adenosine Diphosphate 56-59 LOC101027257 Zea mays 211-222 6648902-2 1983 When bovine unwashed platelets were preincubated with 5-hydroxytryptamine (5HT) (or ADP), they became non responding to that agonist (refractory) but they responded quite normally to collagen, thrombin and ADP (or 5HT). Adenosine Diphosphate 84-87 coagulation factor II, thrombin Bos taurus 193-201 6604123-3 1983 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Adenosine Diphosphate 188-191 complement C3 Homo sapiens 49-52 6134642-2 1983 Treatment of cyc- cells with islet-activating protein (IAP), which causes ADP-ribosylation of an Mr 40 000 polypeptide in cyc- membranes, abolishes adenylate cyclase inhibition by GTP and the peptide hormone, somatostatin, but not that induced by GTP gamma S. Furthermore, somatostatin-induced stimulation of GTP hydrolysis is lost. Adenosine Diphosphate 74-77 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 29-53 6134642-2 1983 Treatment of cyc- cells with islet-activating protein (IAP), which causes ADP-ribosylation of an Mr 40 000 polypeptide in cyc- membranes, abolishes adenylate cyclase inhibition by GTP and the peptide hormone, somatostatin, but not that induced by GTP gamma S. Furthermore, somatostatin-induced stimulation of GTP hydrolysis is lost. Adenosine Diphosphate 74-77 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 55-58 6300102-1 1983 Exposure of NG108-15 hybrid cells to islet-activating protein (IAP), pertussis toxin, caused strong ADP-ribosylation of one of the membrane proteins with a molecular weight of 41,000. Adenosine Diphosphate 100-103 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 37-61 6300102-1 1983 Exposure of NG108-15 hybrid cells to islet-activating protein (IAP), pertussis toxin, caused strong ADP-ribosylation of one of the membrane proteins with a molecular weight of 41,000. Adenosine Diphosphate 100-103 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 63-66 6301374-2 1983 The action of IAP, which occurred after a lag time, was durable and irreversible, and was associated with ADP-ribosylation of a membrane Mr = 41,000 protein. Adenosine Diphosphate 106-109 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Mus musculus 14-17 7142187-7 1982 Glyceraldehyde-3-phosphate dehydrogenase was inhibited by the following compounds (Ki values in parentheses): adenosine (4.34 mM), 5"-AMP (3.50 mM), ADP (2.35 mM), ATP (5.34 mM), and 3",5"-cAMP (0.60 mM). Adenosine Diphosphate 149-152 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 0-40 7179222-6 1982 Unactivated PRP never yielded shear-induced aggregation while samples pre-mixed with low [ADP] (less than or approximately 0.7 microM) led to large visible aggregate formation stable only for G less than or approximately 30-60 sec-1, apparently arising from pre-existing microaggregates. Adenosine Diphosphate 90-93 secretory blood group 1, pseudogene Homo sapiens 227-232 23454376-9 2013 On the other hand, positive modulators that stabilize the tetrameric form of the enzyme, such as fructose-2,6-bisphosphate and ADP, prevent the inhibition of PFK activity by resveratrol, an effect not observed with increased pH. Adenosine Diphosphate 127-130 phosphofructokinase, muscle Homo sapiens 158-161 23588296-7 2013 Pre-treatment with TPO significantly increased the secretion of PDGF-AB and the release of sCD40L, and markedly enhanced the ADP-induced phosphorylation of p38 MAP kinase and HSP27 in the platelets. Adenosine Diphosphate 125-128 heat shock protein family B (small) member 1 Homo sapiens 175-180 23588296-9 2013 These results strongly suggest that pre-treatment with TPO significantly amplifies ADP-induced HSP27 phosphorylation via the p38 MAP kinase pathway in human platelets. Adenosine Diphosphate 83-86 heat shock protein family B (small) member 1 Homo sapiens 95-100 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 205-210 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 428-433 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 428-433 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 205-210 23414428-5 2013 This group had previously reported that the selective P2Y1 receptor antagonist MRS 2179 suppressed the hyperpolarizing action of ATP or ADP. Adenosine Diphosphate 136-139 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 54-67 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 428-433 7179222-7 1982 Direct ADP injections into the flow device showed that at low [ADP] (less than 1 microM), maximal values for both PA and TA were reached when step-wise increases in G reached less than or approximately 30 sec-1, with TA decreasing at higher G; these values were only some 10-20% of maximal values achieved with high (ADP] (greater than or approximately 4 microM), when PA was again maximal at G greater than or approximately 30 sec-1, but TA expressed as a rate of aggregation continued to increase with G up to 150 sec-1. Adenosine Diphosphate 63-66 secretory blood group 1, pseudogene Homo sapiens 428-433 7135345-4 1982 Furthermore, when exposure to PAF-acether was associated to inactivation of platelet cyclooxygenase with aspirin, aggregation to thrombin persisted, validating the claim that thrombin induces aggregation by a third pathway unrelated to ADP and to thromboxane A2. Adenosine Diphosphate 236-239 prothrombin Oryctolagus cuniculus 175-183 23336698-9 2013 ATP and ADP kinetically stabilize PGK1 enzymes, and kinetic stabilization is nucleotide- and mutant-selective. Adenosine Diphosphate 8-11 phosphoglycerate kinase 1 Homo sapiens 34-38 7051409-3 1982 Administration of ADP, collagen or PAF produces an increase in counts in C1, a decrease in counts in C2, and hence an increase in the ratio C1/C2. Adenosine Diphosphate 18-21 complement C2 Cavia porcellus 140-145 23356287-2 2013 ADP is a key platelet agonist that exerts its actions via stimulation of two surface GPCRs (G-protein-coupled receptors), P2Y(1) and P2Y(12). Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 122-128 7051409-4 1982 The rise in C1/C2 is more protracted after collagen administration than after ADP or PAF. Adenosine Diphosphate 78-81 complement C2 Cavia porcellus 12-17 6280177-5 1982 ADP and adenosine 5"-[gamma-thio]triphosphate both inhibit the uvrA ATPase as well as the uvrABC endonuclease and also prevent specific binding of the uvrA proteins to UV-irradiated DNA. Adenosine Diphosphate 0-3 ATPase Escherichia coli 68-74 23026841-1 2012 To clarify the mechanism underlying a high risk of thrombotic complications in diabetic patients, we investigated the relationship between HSP27 phosphorylation and the platelet activation induced by adenosine diphosphate (ADP) in diabetic patients. Adenosine Diphosphate 200-221 heat shock protein family B (small) member 1 Homo sapiens 139-144 6455431-5 1981 Subunit scrambling without loss of the trapped nucleotide is apparent from incubating pPDM-SF1(A2)-[14C]Mg-ADP with unmodified SF1(A1) under similar conditions since the mixture subsequently contains SF1(A1), SF1(A2)h, pPDM-SF1(A1)h-[14C]Mg-ADP and pPDM-SF1(A2)-[14C]Mg-ADP. Adenosine Diphosphate 107-110 splicing factor 1 Homo sapiens 91-94 23026841-1 2012 To clarify the mechanism underlying a high risk of thrombotic complications in diabetic patients, we investigated the relationship between HSP27 phosphorylation and the platelet activation induced by adenosine diphosphate (ADP) in diabetic patients. Adenosine Diphosphate 223-226 heat shock protein family B (small) member 1 Homo sapiens 139-144 23026841-7 2012 In both groups, ADP induced HSP27 phosphorylation at Ser-78 and Ser-82. Adenosine Diphosphate 16-19 heat shock protein family B (small) member 1 Homo sapiens 28-33 23026841-9 2012 There was a significant relationship between the ADP-induced HSP27 phosphorylation level at Ser-78 and the ADP ED50 value of platelet aggregation. Adenosine Diphosphate 49-52 heat shock protein family B (small) member 1 Homo sapiens 61-66 23026841-9 2012 There was a significant relationship between the ADP-induced HSP27 phosphorylation level at Ser-78 and the ADP ED50 value of platelet aggregation. Adenosine Diphosphate 107-110 heat shock protein family B (small) member 1 Homo sapiens 61-66 23026841-11 2012 The use of aspirin ameliorated the accelerated microaggregation of platelets in Group 1, and the low-dose ADP-induced phosphorylation of HSP27 at Ser-78 was no longer observed. Adenosine Diphosphate 106-109 heat shock protein family B (small) member 1 Homo sapiens 137-142 23026841-12 2012 These results strongly suggest that the phosphorylation of HSP27 at Ser-78 is correlated with the acceleration of platelet aggregation induced by ADP in type 2 DM patients. Adenosine Diphosphate 146-149 heat shock protein family B (small) member 1 Homo sapiens 59-64 23121488-5 2012 This correlates well with the biological dissociation of Mg ADP from myosin after the hydrolysis of ATP. Adenosine Diphosphate 57-63 myosin heavy chain 14 Homo sapiens 69-75 7042956-3 1981 Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) induced an immediate and considerable insulin secretion which persisted during the 30 min administration period. Adenosine Diphosphate 33-54 insulin Canis lupus familiaris 99-106 22890994-6 2012 Both parasite secreted products and the 5"-nucleotidase inhibit ADP-induced release of mast cell protease, whereas that stimulated by ATP is partially inhibited by secreted products alone. Adenosine Diphosphate 64-67 5' nucleotidase, ecto Mus musculus 40-55 22907058-2 2012 However, ADP/ATP diffusion through adenine nucleotide translocase (ANT) and voltage-dependent anion carriers (VDACs) is also involved in this process. Adenosine Diphosphate 9-12 solute carrier family 25 member 6 Homo sapiens 35-65 22907058-2 2012 However, ADP/ATP diffusion through adenine nucleotide translocase (ANT) and voltage-dependent anion carriers (VDACs) is also involved in this process. Adenosine Diphosphate 9-12 solute carrier family 25 member 6 Homo sapiens 67-70 22907058-5 2012 In the absence of contractile signals (relaxed PmFBs) and miCK activity (no Cr), post-exercise respiratory sensitivity to ADP was reduced in situ (up to 126% higher apparent K(m) to ADP) suggesting inhibition of ADP/ATP diffusion between matrix and cytosolic compartments (possibly ANT and VDACs). Adenosine Diphosphate 122-125 solute carrier family 25 member 6 Homo sapiens 282-285 7042956-3 1981 Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) induced an immediate and considerable insulin secretion which persisted during the 30 min administration period. Adenosine Diphosphate 56-59 insulin Canis lupus familiaris 99-106 7023319-3 1981 That ADP- or collagen-treated platelets can promote the proteolytic activation of factor XII in mixtures containing kallikrein and HMW kininogen was shown by (1) the proteolytic cleavage of factor XII, (2) the development of factor XIIa coagulant activity, and (3) the proteolytic cleavage of 125I-labeled factor XII. Adenosine Diphosphate 5-8 kallikrein related peptidase 4 Homo sapiens 116-126 6110570-8 1980 In conclusion, somatostatin counteracts the decrease of platelet aggregation response to ADP seen in saline studies, induces the appearance of platelet aggregates in diabetics and potentiates the aggregation response to epinephrine (in vitro) in both normals and diabetics. Adenosine Diphosphate 89-92 somatostatin Homo sapiens 15-27 23166924-1 2012 When bound to ADP, ATP-dependent protease FtsH subunits adopt either an "open" or "closed" conformation. Adenosine Diphosphate 14-17 YME1 like 1 ATPase Homo sapiens 42-46 22549780-5 2012 We employed tandem mass spectrometry analysis to identify sites of ADP-ribosylation on vimentin. Adenosine Diphosphate 67-70 vimentin Homo sapiens 87-95 6933565-3 1980 PGK-Uppsala had a lower-than-normal specific activity (30% of normal in the backward reaction and about 20% of normal in the forward reaction) and higher-than-normal Michaelis constants for ATP, ADP, 3-phosphoglycerate and 1,3-diphosphoglycerate. Adenosine Diphosphate 195-198 phosphoglycerate kinase 1 Equus caballus 0-3 30781912-4 1979 Adenosine, AMP, 2- chloroadenosine, alpha,beta-methylene ADP and beta,gamma-methylene ATP each inhibited ATP-induced aggregation of platelets in rat PRP to a similar extent as ADP-induced aggregation. Adenosine Diphosphate 57-60 proline rich protein 2-like 1 Rattus norvegicus 149-152 22546677-1 2012 Ticagrelor (1) is the first reversible P2Y12 receptor antagonist blocking adenine diphosphate (ADP)-induced platelet aggregation with rapid onset and offset of effects. Adenosine Diphosphate 95-98 purinergic receptor P2Y12 Rattus norvegicus 39-44 30781912-5 1979 A solution containing creatine kinase and creatine phosphate (which converts ADP to ATP) rapidly reversed both ADP- and ATP-induced aggregation in rat PRP; preincubation with this solution completely inhibited rat platelet aggregation induced by both ADP and ATP. Adenosine Diphosphate 77-80 proline rich protein 2-like 1 Rattus norvegicus 151-154 30781912-5 1979 A solution containing creatine kinase and creatine phosphate (which converts ADP to ATP) rapidly reversed both ADP- and ATP-induced aggregation in rat PRP; preincubation with this solution completely inhibited rat platelet aggregation induced by both ADP and ATP. Adenosine Diphosphate 111-114 proline rich protein 2-like 1 Rattus norvegicus 151-154 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Diphosphate 22-43 5' nucleotidase, ecto Mus musculus 264-268 30781912-5 1979 A solution containing creatine kinase and creatine phosphate (which converts ADP to ATP) rapidly reversed both ADP- and ATP-induced aggregation in rat PRP; preincubation with this solution completely inhibited rat platelet aggregation induced by both ADP and ATP. Adenosine Diphosphate 111-114 proline rich protein 2-like 1 Rattus norvegicus 151-154 30781912-9 1979 These results suggest that the observed phenomenon of ATP-induced aggregation in rat PRP is caused by a higher activity of creatine kinase in rat plasma than in human plasma, which converts the added ATP to ADP, a potent aggregator. Adenosine Diphosphate 207-210 proline rich protein 2-like 1 Rattus norvegicus 85-88 582779-4 1979 With ADP in excess (5 mmol/l) carbocromen decreased QO2 in state ST3 by about 35%. Adenosine Diphosphate 5-8 matrix metallopeptidase 11 Rattus norvegicus 65-68 21950486-5 2012 KEY RESULTS: Compared with ASA, ASA + M strongly inhibited ADP-induced peak platelet aggregation (88%), late aggregation (84%), P-selectin expression (85%) and alpha(IIb) beta(3) activation (62%) (28%, 65%, 70% and 51% inhibition, respectively, for ASA/C vs. ASA). Adenosine Diphosphate 59-62 selectin P Homo sapiens 128-138 22401797-11 2012 CONCLUSION: We identified that Tg directly induces platelet activation and demonstrated that Tg-induced platelet activation depends on dense granule secretion of ADP, which in turn activates the P2Y1 and P2Y12 receptor signaling pathways. Adenosine Diphosphate 162-165 purinergic receptor P2Y12 Rattus norvegicus 204-209 154823-6 1978 In the prence of added ADP, an increase in AMP concentration was also brought about by addition of Cd2+. Adenosine Diphosphate 23-26 Cd2 molecule Rattus norvegicus 99-102 22294727-6 2012 Expression of P-selectin and activated GPIIb/IIIa in response to high-dose ADP was lower during eltrombopag treatment than at baseline. Adenosine Diphosphate 75-78 selectin P Homo sapiens 14-24 22351627-4 2012 IJPs and hyperpolarization responses to ADPR, but not ADP, were inhibited by the P2Y1 receptor antagonist (1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt (MRS2500). Adenosine Diphosphate 40-43 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 81-94 338619-4 1977 Studies with HS3 isolated from Achlya and partially purified mammalian ribonucleotide reductase indicated that the compound noncompetitively inhibited the reduction of varying concentrations of the substrates CDP, ADP and GDP with Ki values of 23 micrometer, 14 micron and 16 micron respectively. Adenosine Diphosphate 214-217 spectrin alpha, erythrocytic 1 Homo sapiens 13-16 22371476-7 2012 Picospritzing of neurotransmitter candidates (ATP and its primary metabolite, ADP) and beta-NAD (and its primary metabolite, ADP-ribose, ADPR) caused transient hyperpolarization responses in wild-type colons, but responses to beta-NAD and ADPR were completely abolished in P2ry1(-/-) mice. Adenosine Diphosphate 78-81 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 273-278 22371476-8 2012 Hyperpolarization and relaxation responses to ATP and ADP were retained in colons of P2ry1(-/-) mice. Adenosine Diphosphate 54-57 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 85-90 22041339-3 2012 Tau and Abeta immunoreactivities were observed in the AD group and the DLB group with ADP, but were rare in the DLB group without ADP. Adenosine Diphosphate 86-89 microtubule associated protein tau Homo sapiens 0-3 22041339-4 2012 Tau and Abeta immunoreactivities as well as numbers of neurofibrillary tangles (NFTs) and neuritic plaques (NPs) were more common in the AD group than in the DLB group with ADP. Adenosine Diphosphate 173-176 microtubule associated protein tau Homo sapiens 0-3 191063-0 1977 Spin-labeled acyl atractyloside as a probe of the mitochondrial adenosine diphosphate carrier. Adenosine Diphosphate 64-85 spindlin 1 Homo sapiens 0-4 191063-4 1977 Spin-labeled acyl-ATRs were used to probe the ADP carrier in heart mitochondria. Adenosine Diphosphate 46-49 spindlin 1 Homo sapiens 0-4 1010856-5 1976 Insulin stimulated allose transport, into or out of the cell, but not basal transport, is inhibited by a brief exposure of isolated fat-cells to exogenous ATP or ADP (but not AMP or AMP-PNP). Adenosine Diphosphate 162-165 insulin Canis lupus familiaris 0-7 22306293-1 2012 Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. Adenosine Diphosphate 160-163 pyruvate kinase M1/2 Homo sapiens 0-26 22306293-1 2012 Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. Adenosine Diphosphate 160-163 pyruvate kinase M1/2 Homo sapiens 28-32 22306293-6 2012 ADP competes with the protein substrate binding, indicating that the substrate may bind to the ADP site of PKM2. Adenosine Diphosphate 0-3 pyruvate kinase M1/2 Homo sapiens 107-111 22306293-6 2012 ADP competes with the protein substrate binding, indicating that the substrate may bind to the ADP site of PKM2. Adenosine Diphosphate 95-98 pyruvate kinase M1/2 Homo sapiens 107-111 175045-5 1975 More than 90% of cytochrome b5 was reduced under conditions where 90% of the alpha-NADH-DCPIP reductase activity was suppressed with ADP. Adenosine Diphosphate 133-136 cytochrome b5 type A Rattus norvegicus 17-30 1226428-2 1975 In this system, ATP produced in Mit from added ADP caused the superprecipitation of the myosin B (My-B). Adenosine Diphosphate 47-50 MYB proto-oncogene, transcription factor Canis lupus familiaris 88-96 22302802-6 2012 LRRK2 inhibition blocks TLR4 stimulated microglial process outgrowth and impairs ADP stimulated microglial chemotaxis. Adenosine Diphosphate 81-84 leucine-rich repeat kinase 2 Rattus norvegicus 0-5 1226428-2 1975 In this system, ATP produced in Mit from added ADP caused the superprecipitation of the myosin B (My-B). Adenosine Diphosphate 47-50 MYB proto-oncogene, transcription factor Canis lupus familiaris 98-102 4725035-15 1973 The results suggest that the metabolism of pyruvate via pyruvate carboxylase in brain mitochondria is regulated, in part, by the intramitochondrial concentrations of pyruvate, oxaloacetate and the ATP:ADP ratio. Adenosine Diphosphate 201-204 pyruvate carboxylase Rattus norvegicus 56-76 22062585-8 2012 Using purified NOD1 protein for nucleotide binding studies by the Fluorescence Polarization Assay (FPA) method, we determined that NOD1 binds preferentially to ATP over ADP and AMP or dATP. Adenosine Diphosphate 169-172 nucleotide binding oligomerization domain containing 1 Homo sapiens 15-19 22062585-8 2012 Using purified NOD1 protein for nucleotide binding studies by the Fluorescence Polarization Assay (FPA) method, we determined that NOD1 binds preferentially to ATP over ADP and AMP or dATP. Adenosine Diphosphate 169-172 nucleotide binding oligomerization domain containing 1 Homo sapiens 131-135 21736422-7 2012 Furthermore, while succinate alone had no effect in the presence of platelet inhibitors, responsiveness of platelets to ADP after pretreatment with P2Y(1) or P2Y(12) antagonists was fully restored, when platelets were co-stimulated with 100 microM succinate. Adenosine Diphosphate 120-123 purinergic receptor P2Y1 Homo sapiens 148-154 5639161-0 1968 Inhibition by adenosine diphosphate of the thrombocytopenia induced in rabbits by collagen or thrombin. Adenosine Diphosphate 14-35 prothrombin Oryctolagus cuniculus 94-102 21767238-22 2012 Platelet aggregation on ADP(10) and AA significantly increased by ERT(6) (ADP(10): ERT(0) 0.75, ERT(6) 0.8 p < 0.01; AA: ERT(0) 0.7, ERT(6) 0.8 p < 0.05). Adenosine Diphosphate 24-27 E74 like ETS transcription factor 3 Homo sapiens 66-69 21767238-22 2012 Platelet aggregation on ADP(10) and AA significantly increased by ERT(6) (ADP(10): ERT(0) 0.75, ERT(6) 0.8 p < 0.01; AA: ERT(0) 0.7, ERT(6) 0.8 p < 0.05). Adenosine Diphosphate 24-27 E74 like ETS transcription factor 3 Homo sapiens 83-86 21767238-22 2012 Platelet aggregation on ADP(10) and AA significantly increased by ERT(6) (ADP(10): ERT(0) 0.75, ERT(6) 0.8 p < 0.01; AA: ERT(0) 0.7, ERT(6) 0.8 p < 0.05). Adenosine Diphosphate 24-27 E74 like ETS transcription factor 3 Homo sapiens 83-86 21767238-22 2012 Platelet aggregation on ADP(10) and AA significantly increased by ERT(6) (ADP(10): ERT(0) 0.75, ERT(6) 0.8 p < 0.01; AA: ERT(0) 0.7, ERT(6) 0.8 p < 0.05). Adenosine Diphosphate 24-27 E74 like ETS transcription factor 3 Homo sapiens 83-86 5969281-4 1966 The reaction of 5"-phosphoribosyl pyrophosphate with adenine phosphoribosyltransferase from ascites-tumour cells (K(m) 6.5-11.9mum) was competitively inhibited by AMP, ADP, ATP and GMP (K(i) 7.5, 21.9, 395 and 118mum respectively). Adenosine Diphosphate 168-171 5'-nucleotidase, cytosolic II Homo sapiens 181-184 21767238-22 2012 Platelet aggregation on ADP(10) and AA significantly increased by ERT(6) (ADP(10): ERT(0) 0.75, ERT(6) 0.8 p < 0.01; AA: ERT(0) 0.7, ERT(6) 0.8 p < 0.05). Adenosine Diphosphate 24-27 E74 like ETS transcription factor 3 Homo sapiens 83-86 34029503-11 2022 Expression of GP IIb-IIIa activated form correlated with RP percentage and platelet size indexes when platelets were activated by TRAP and ADP at both applied concentrations (r from 0.309 to 0.560, p from 0.014 to < 0.001, n = 50-62). Adenosine Diphosphate 139-142 integrin subunit alpha 2b Homo sapiens 14-20 23236426-1 2012 BACKGROUND: ADP is an important physiological agonist that induces integrin activation and platelet aggregation through its receptors P2Y(1) (Galpha(q)-coupled) and P2Y(12) (Galpha(i)-coupled). Adenosine Diphosphate 12-15 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 134-140 34029503-12 2022 P-selectin expression correlated with RP percentage and platelet size indexes when platelets were activated by 10 microM TRAP inducing maximum expression of this activation marker (r from 0.332 to 0.556, p from 0.008 to < 0.001, n = 65), but not by weaker agonists: 1 microM TRAP, 20 and 2.5 microM ADP (r < 0.3, n = 54-66). Adenosine Diphosphate 299-302 TRAP Homo sapiens 121-125 23029387-5 2012 Lovastatin treatment impaired mitochondrial function and also decreased cellular ADP/ATP ratios, common triggers of LKB1/AMPK activation. Adenosine Diphosphate 81-84 serine/threonine kinase 11 Homo sapiens 116-120 22879887-7 2012 On the other hand, HNP-1 strongly influenced NarE inhibiting its transferase activity while enhancing auto-ADP-ribosylation. Adenosine Diphosphate 107-110 HNP1 Homo sapiens 19-24 32803738-0 2021 MRP4 over-expression has a role on both reducing nitric oxide-dependent antiplatelet effect and enhancing ADP induced platelet activation. Adenosine Diphosphate 106-109 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 22792409-3 2012 Extracellular dephosphorylation of ATP to ADP and AMP occurs primarily via CD39 (ENTPD1), an ectonucleotidase found on the surface of leukocytes, platelets, and endothelial cells. Adenosine Diphosphate 42-45 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 75-79 22792409-3 2012 Extracellular dephosphorylation of ATP to ADP and AMP occurs primarily via CD39 (ENTPD1), an ectonucleotidase found on the surface of leukocytes, platelets, and endothelial cells. Adenosine Diphosphate 42-45 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 81-87 32803738-3 2021 Moreover, we assessed if inhibition of MRP4-mediated transport reduces ADP-induced platelet reactivity. Adenosine Diphosphate 71-74 ATP binding cassette subfamily C member 4 Homo sapiens 39-43 32803738-6 2021 The impact of MRP4 on ADP-induced platelet aggregation was performed in high on aspirin residual platelet reactivity (HARPR) patients and compared to healthy volunteers (HV), and a control cohort (CTR). Adenosine Diphosphate 22-25 ATP binding cassette subfamily C member 4 Homo sapiens 14-18 32803738-8 2021 MRP4 inhibition by cilostazol significantly reduced ADP-induced platelet aggregation in HARPR population, and to a lesser extent in HV and CTR populations. Adenosine Diphosphate 52-55 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 22050912-4 2011 The swelling was markedly suppressed by ADP [an adenine nucleotide translocator (ANT) ligand] and partially suppressed by cyclosporin A or by GST inhibitors (tannic acid, S-hexylglutathione). Adenosine Diphosphate 40-43 solute carrier family 25 member 6 Homo sapiens 48-79 22050912-4 2011 The swelling was markedly suppressed by ADP [an adenine nucleotide translocator (ANT) ligand] and partially suppressed by cyclosporin A or by GST inhibitors (tannic acid, S-hexylglutathione). Adenosine Diphosphate 40-43 solute carrier family 25 member 6 Homo sapiens 81-84 32773283-9 2021 CONCLUSIONS: Imbalance in extracellular ADP degradation by NTPDase1 may promote macrophage activation, and activated macrophages may be an important cause of graft damage. Adenosine Diphosphate 40-43 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 59-67 21541983-4 2011 When the membrane potentials at which these two molecular entities reverse directionality, termed reversal potential (Erev), are plotted as a function of matrix ATP/ADP ratio, an area of the plot is bracketed by the Erev_ATPase and the Erev_ANT, which we call "B space". Adenosine Diphosphate 165-168 solute carrier family 25 member 6 Homo sapiens 241-244 33199206-7 2020 Seven reported ADP cases had compound heterozygous ALAD mutations resulting in very low residual ALAD activity and symptoms early in life or adolescence. Adenosine Diphosphate 15-18 aminolevulinate dehydratase Homo sapiens 51-55 21941165-4 2011 Platelet activation stimulated by ADP was studied by measuring surface P-selectin with flow cytometry. Adenosine Diphosphate 34-37 selectin P Homo sapiens 71-81 33199206-7 2020 Seven reported ADP cases had compound heterozygous ALAD mutations resulting in very low residual ALAD activity and symptoms early in life or adolescence. Adenosine Diphosphate 15-18 aminolevulinate dehydratase Homo sapiens 97-101 33199206-8 2020 One adult with a germline ALAD mutant allele developed ADP in association with a clonal myeloproliferative disorder, polycythemia vera. Adenosine Diphosphate 55-58 aminolevulinate dehydratase Homo sapiens 26-30 33269349-1 2020 The SARS-CoV-2 macrodomain (Mac1) within the non-structural protein 3 (Nsp3) counteracts host-mediated antiviral ADP-ribosylation signalling. Adenosine Diphosphate 113-116 integrin subunit alpha M Homo sapiens 28-32 21872609-8 2011 We performed MD simulations in which the L5-domain of the Eg5 ADP X-ray structure was manually deformed via backbone bond rotations. Adenosine Diphosphate 62-65 kinesin family member 11 Homo sapiens 58-61 32999463-5 2020 ATP triggers the recruitment of microglial protrusions and is converted by the microglial ATP/ADP hydrolysing ectoenzyme CD39 into AMP; AMP is then converted into adenosine by CD73, which is expressed on microglia as well as other brain cells. Adenosine Diphosphate 94-97 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 121-125 21872609-9 2011 The L5-domain of Eg5 was sufficiently lengthy that portions of L5 could be located in proximity to bound ADP. Adenosine Diphosphate 105-108 kinesin family member 11 Homo sapiens 17-20 32588751-8 2020 Conclusions: Upon activation a NAADP/SERCA3 Ca2+ mobilization pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave of ADP secretion driven by both an IP3/SERCA2b-dependent Ca2+ stores pathway and the NAADP/SERCA3 pathway. Adenosine Diphosphate 33-36 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Mus musculus 198-205 21872198-5 2011 Post-treatment platelet reactivity was assessed by adenosine diphosphate 10 mumol/L-induced platelet aggregation and the specific pharmacologic response to clopidogrel by the platelet reactivity index vasoactive stimulated phosphoprotein. Adenosine Diphosphate 51-72 solute carrier family 35 member G1 Homo sapiens 0-4 21872198-6 2011 High post-treatment platelet reactivity was defined as adenosine diphosphate 10 mumol/L-induced platelet aggregation >70%. Adenosine Diphosphate 55-76 solute carrier family 35 member G1 Homo sapiens 5-9 21982178-10 2011 The ATP level was reduced, and the ADP/ATP ratio as an apoptotic index significantly increased in the tbx5 deficient embryos. Adenosine Diphosphate 35-38 T-box transcription factor 5a Danio rerio 102-106 21974986-10 2011 siRNA knockdown experiments suggested that ADP 355 effects can be transmitted through both adiponectin receptors, with a greater contribution of AdipoR1. Adenosine Diphosphate 43-46 adiponectin receptor 1 Homo sapiens 145-152 21698747-4 2011 In the presence of aldolase, PFK is not modulated by its allosteric activators, ADP and fructose-2,6-bisphosphate, but is still inhibited by citrate and lactate. Adenosine Diphosphate 80-83 phosphofructokinase, muscle Homo sapiens 29-32 21389046-2 2011 The human NUDT5, which has an intrinsic activity to cleave ADP sugars to AMP and sugar phosphate, possesses the ability to degrade 8-oxo-dGDP to the monophosphate. Adenosine Diphosphate 59-62 nudix hydrolase 5 Homo sapiens 10-15 21427288-7 2011 Furthermore, flow cytometric analysis revealed that Vav1/Vav3 deficiency significantly inhibited oxLDL-mediated integrin alphaIIbbetaIII activation of platelets costimulated with ADP. Adenosine Diphosphate 179-182 vav 1 oncogene Mus musculus 52-56 21427288-7 2011 Furthermore, flow cytometric analysis revealed that Vav1/Vav3 deficiency significantly inhibited oxLDL-mediated integrin alphaIIbbetaIII activation of platelets costimulated with ADP. Adenosine Diphosphate 179-182 vav 3 oncogene Mus musculus 57-61 21518981-4 2011 The GPx-3((-/-)) mice showed an attenuated bleeding time and an enhanced aggregation response to the agonist ADP compared with wild-type mice. Adenosine Diphosphate 109-112 glutathione peroxidase 3 Mus musculus 4-9 21518981-6 2011 ADP infusion-induced platelet aggregation in the pulmonary vasculature produced a more robust platelet activation response in the GPx-3((-/-)) than wild-type mice; histological sections from the pulmonary vasculature of GPx-3((-/-)) compared with wild-type mice showed increased platelet-rich thrombi and a higher percentage of occluded vessels. Adenosine Diphosphate 0-3 glutathione peroxidase 3 Mus musculus 130-135 21518981-6 2011 ADP infusion-induced platelet aggregation in the pulmonary vasculature produced a more robust platelet activation response in the GPx-3((-/-)) than wild-type mice; histological sections from the pulmonary vasculature of GPx-3((-/-)) compared with wild-type mice showed increased platelet-rich thrombi and a higher percentage of occluded vessels. Adenosine Diphosphate 0-3 glutathione peroxidase 3 Mus musculus 220-225 21192710-2 2011 Crystal structures of Eg5, one of the best-studied kinesins, have been solved in both ADP-bound and ATP-bound states. Adenosine Diphosphate 86-89 kinesin family member 11 Homo sapiens 22-25 21059654-7 2011 We demonstrate that beta-cells with reduced ARNT/HIF-1beta expression levels exhibit a 31% reduction in glycolytic flux without significant changes in glucose oxidation or the ATP:ADP ratio. Adenosine Diphosphate 180-183 aryl hydrocarbon receptor nuclear translocator Homo sapiens 44-48 21134286-9 2010 In ADP-stimulated PRP, NSC23766 almost completely inhibited P-selectin expression, in contrast to aspirin, which was ineffective. Adenosine Diphosphate 3-6 selectin P Homo sapiens 60-70 21071691-6 2010 A selective EP4 agonist (ONO AE1-329) potently inhibited the platelet aggregation as induced by ADP or collagen. Adenosine Diphosphate 96-99 prostaglandin E receptor 4 Homo sapiens 12-15 20070990-10 2010 Multiple regression analysis showed that percentage change of ADP-induced platelet aggregate formation (standardized beta = 0.540, P < .05) was independently associated with percentage change of plasma PAI-1 level in addition to percentage change of HbA(1c) (standardized beta = 0.657, P < .05) (R = 0.939, P < .05) after switching to gliclazide. Adenosine Diphosphate 62-65 serpin family E member 1 Homo sapiens 205-210 20443048-9 2010 Moreover, the L-carnitine dependent ADP-induced mitochondrial oxygen consumption did not increase when PLA(2) inhibitors were treated before ADP treatment. Adenosine Diphosphate 36-39 phospholipase A2 group IB Rattus norvegicus 103-109 20546121-5 2010 Human Gas6 synergizes with ADP-P2Y(12) by enhancing and prolonging the phosphorylation of Akt. Adenosine Diphosphate 27-30 growth arrest specific 6 Homo sapiens 6-10 20546121-6 2010 Removal of Gas6 from plasma impaired ADP-induced platelet aggregation. Adenosine Diphosphate 37-40 growth arrest specific 6 Homo sapiens 11-15 20546121-9 2010 In mouse blood, deficiency in Gas6 or in one of the TAM receptors led to reduced thrombus formation and increased disaggregation, which was completely antagonized by external ADP. Adenosine Diphosphate 175-178 growth arrest specific 6 Mus musculus 30-34 20546121-12 2010 We postulate a model of thrombus stabilization in which plasma Gas6, by signaling via the TAM receptors, extends and enhances the platelet-stabilizing effect of autocrine ADP, particularly when secretion becomes limited. Adenosine Diphosphate 171-174 growth arrest specific 6 Homo sapiens 63-67 20512113-3 2010 The structures of p97 N-D1 fragments bearing IBMPFD mutations adopt an atypical N-domain conformation in the presence of Mg(2+).ATPgammaS, which is reversible by ADP, showing for the first time the nucleotide-dependent conformational change of the N-domain. Adenosine Diphosphate 162-165 melanotransferrin Homo sapiens 18-21 20512113-4 2010 The transition from the ADP- to the ATPgammaS-bound state is accompanied by a loop-to-helix conversion in the N-D1 linker and by an apparent re-ordering in the N-terminal region of p97. Adenosine Diphosphate 24-27 melanotransferrin Homo sapiens 181-184 20303336-9 2010 TEA did not negatively affect parameters of beta-cell energy metabolism (NAD(P)H fluorescence and ATP/ADP ratio), rather, it slightly increased NAD(P)H fluorescence. Adenosine Diphosphate 102-105 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 20519952-3 2010 These compounds bind within the ADP/ATP-binding site of the Hsp90 N-terminal domain to inhibit its ATPase activity. Adenosine Diphosphate 32-35 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 60-65 20091784-7 2010 In addition, time-lapse imaging of EGFP-labeled microglia in mice hippocampal slices showed that RGD inhibited the directional process extension toward the nucleotide source, and immunohistochemical staining showed that integrin-beta1 accumulated in the tips of the microglial processes in rat hippocampal slices stimulated with ADP. Adenosine Diphosphate 329-332 integrin beta 1 (fibronectin receptor beta) Mus musculus 220-234 20060930-1 2010 The adenine nucleotide translocator (ANT) is a mitochondrial bi-functional protein, which catalyzes the exchange of ADP and ATP between cytosol and mitochondria and participates in many models of mitochondrial apoptosis. Adenosine Diphosphate 116-119 solute carrier family 25 member 6 Homo sapiens 37-40 20351242-0 2010 Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 0-6 20351242-2 2010 To gain insight into this process, we used well-established single-tryptophan and pyrene fluorescent sensors and electron microscopy to characterize the structural and kinetic properties of myosin complexed with ADP and blebbistatin, a widely used inhibitor. Adenosine Diphosphate 212-215 myosin heavy chain 14 Homo sapiens 190-196 20351242-4 2010 The results indicate that a significant fraction of the myosin.ADP.blebbistatin complex populates a previously inaccessible conformation of myosin resembling the start of the powerstroke. Adenosine Diphosphate 63-66 myosin heavy chain 14 Homo sapiens 56-62 20351242-4 2010 The results indicate that a significant fraction of the myosin.ADP.blebbistatin complex populates a previously inaccessible conformation of myosin resembling the start of the powerstroke. Adenosine Diphosphate 63-66 myosin heavy chain 14 Homo sapiens 140-146 19861313-1 2010 BACKGROUND: Adenosine, a potent regulator of inflammation, is produced under stressful conditions due to degradation of ATP/ADP by the ectoenzymes CD39 and CD73. Adenosine Diphosphate 124-127 5' nucleotidase, ecto Mus musculus 156-160 19790263-3 2010 Our modeling of allosteric couplings at the pre-powerstroke state has pinpointed key actin-activated couplings to distant myosin parts which are critical to force generation and the sequential release of phosphate and ADP. Adenosine Diphosphate 218-221 myosin heavy chain 14 Homo sapiens 122-128 19790263-4 2010 At the post-powerstroke state, we have identified isoform-dependent couplings which underlie the reciprocal coupling between actin binding and nucleotide binding in fast Myosin II, and load-dependent ADP release in Myosin V. Adenosine Diphosphate 200-203 myosin heavy chain 14 Homo sapiens 170-176 19768661-7 2010 Inhibition of ANT causes increased mitochondrial oxidation, loss of ADP uptake, mitochondrial translocation of bax, and apoptosis. Adenosine Diphosphate 68-71 solute carrier family 25 member 6 Homo sapiens 14-17 20049953-6 2010 However, Clic1(-) (/-) mice show a mild platelet dysfunction characterized by prolonged bleeding times and decreased platelet activation in response to adenosine diphosphate stimulation linked to P2Y(12) receptor signaling. Adenosine Diphosphate 152-173 chloride intracellular channel 1 Mus musculus 9-14 19897460-7 2010 MPA after ADP stimulation increased more significantly at peak EST-1 compared with peak EST-2 (p<0.001). Adenosine Diphosphate 10-13 sulfotransferase family 1E member 1 Homo sapiens 63-68 20024494-10 2010 Consequently, ADP-inducible expression of P-selectin was higher after valve replacement (p=0.001). Adenosine Diphosphate 14-17 selectin P Homo sapiens 42-52 19779037-6 2010 The effect of high-dose cangrelor is more consistent and demonstrates a greater level of inhibition on adenosine diphosphate-induced P-selectin expression; how ever, no significant differences are observed between the 2 dosing regimens with regard to platelet aggregation or time to recovery of platelet function. Adenosine Diphosphate 103-124 selectin P Homo sapiens 133-143 20087952-5 2010 The CD62P expression of the ADP-activated platelets were correlated with the Delta platelet count (r=0.517) in the short-term storage group (within 10 hr from preparation), with the platelet component distribution width (PCDW) without ADP (r=-0.744) and the DeltaPCDW (r=-0.755) in the long-term storage group (after 10 hr from preparation). Adenosine Diphosphate 28-31 selectin P Homo sapiens 4-9 20472150-8 2010 Therefore, GSK-3beta/beta-catenin pathway may be important in the reciprocal actions of GCs and Li on ADP proliferation. Adenosine Diphosphate 102-105 catenin beta 1 Rattus norvegicus 21-33 19897717-6 2009 In the present study, we observed that ART1-catalyzed ADP-ribosylation of HNP-1 in vitro generated a product with ADP-ribose on arginine 24, and ornithine replacing arginine at position 14. Adenosine Diphosphate 54-57 HNP1 Homo sapiens 74-79 19783664-4 2009 Although eNOS activity was stimulated by both ADP and ATP, only ADP signaling was significantly inhibited by the P2Y(1) receptor antagonist MRS 2179 or by knockdown of P2Y(1) using small interfering RNA (siRNA). Adenosine Diphosphate 64-67 purinergic receptor P2Y1 Homo sapiens 113-128 19783664-4 2009 Although eNOS activity was stimulated by both ADP and ATP, only ADP signaling was significantly inhibited by the P2Y(1) receptor antagonist MRS 2179 or by knockdown of P2Y(1) using small interfering RNA (siRNA). Adenosine Diphosphate 64-67 purinergic receptor P2Y1 Homo sapiens 113-119 19783664-11 2009 CaMKKbeta knockdown suppressed ADP-stimulated eNOS activity, yet inhibition of CaMKKbeta kinase activity using STO-609 failed to affect eNOS activation by ADP. Adenosine Diphosphate 31-34 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 0-9 19783664-12 2009 These data suggest that the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS. Adenosine Diphosphate 108-111 calcium/calmodulin dependent protein kinase kinase 2 Homo sapiens 81-90 19644512-4 2009 In fact, mitochondria isolated from hearts of TG2(-/-) mice exhibit increased polymerization of ANT1, paralleled by an enhanced ADP/ATP carrier activity, as compared to mitochondria belonging to TG2(+/+) mice. Adenosine Diphosphate 128-131 transglutaminase 2, C polypeptide Mus musculus 46-49 19644512-5 2009 Interestingly, upon cell-death induction, ANT1 becomes a substrate for TG2"s cross-linking activity and the lack of TG2 results in a reduction of apoptosis as well as in a marked sensitivity to the ADP/ATP exchange inhibition by atractyloside. Adenosine Diphosphate 198-201 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 42-46 19644512-5 2009 Interestingly, upon cell-death induction, ANT1 becomes a substrate for TG2"s cross-linking activity and the lack of TG2 results in a reduction of apoptosis as well as in a marked sensitivity to the ADP/ATP exchange inhibition by atractyloside. Adenosine Diphosphate 198-201 transglutaminase 2, C polypeptide Mus musculus 71-74 19644512-5 2009 Interestingly, upon cell-death induction, ANT1 becomes a substrate for TG2"s cross-linking activity and the lack of TG2 results in a reduction of apoptosis as well as in a marked sensitivity to the ADP/ATP exchange inhibition by atractyloside. Adenosine Diphosphate 198-201 transglutaminase 2, C polypeptide Mus musculus 116-119 19691476-12 2009 Spreading could be restored in Cib1 null platelets by the addition of exogenous ADP. Adenosine Diphosphate 80-83 calcium and integrin binding 1 (calmyrin) Mus musculus 31-35 19852691-7 2009 Platelet surface P-selectin (basal and in response to 0.5 or 20 microM ADP) was higher in nephropathy patients compared with normoalbuminuric patients (P = 0.027), and non-diabetic controls (P = 0.0057). Adenosine Diphosphate 71-74 selectin P Homo sapiens 17-27 19559024-5 2009 The ADP-stimulated HSP27 phosphorylation was markedly reduced by alphaB-crystallin. Adenosine Diphosphate 4-7 heat shock protein family B (small) member 1 Homo sapiens 19-24 19759867-8 2009 Interaction between ANT and Abeta may affect normal physiological function of ANT i.e. transport of ATP and ADP. Adenosine Diphosphate 108-111 solute carrier family 25 member 6 Homo sapiens 20-23 19759867-8 2009 Interaction between ANT and Abeta may affect normal physiological function of ANT i.e. transport of ATP and ADP. Adenosine Diphosphate 108-111 solute carrier family 25 member 6 Homo sapiens 78-81 19250982-7 2009 Moreover, CaM activates PFK in the presence of citrate and lactate, two inhibitory metabolites that induce the dimerization of PFK tetramers, as well as potentiate the stimulatory action of ADP and fructose-2,6-bisphosphate. Adenosine Diphosphate 190-193 phosphofructokinase, muscle Homo sapiens 24-27 19637098-4 2009 SNPs in P2RY1 and ITGB3 have also been reported by some groups to affect platelet reactivity to adenosine diphosphate (ADP). Adenosine Diphosphate 96-117 purinergic receptor P2Y1 Homo sapiens 8-13 19637098-4 2009 SNPs in P2RY1 and ITGB3 have also been reported by some groups to affect platelet reactivity to adenosine diphosphate (ADP). Adenosine Diphosphate 119-122 purinergic receptor P2Y1 Homo sapiens 8-13 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 77-80 myosin heavy chain 14 Homo sapiens 94-100 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 77-80 myosin heavy chain 14 Homo sapiens 245-251 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 169-172 myosin heavy chain 14 Homo sapiens 94-100 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 169-172 myosin heavy chain 14 Homo sapiens 245-251 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 169-172 myosin heavy chain 14 Homo sapiens 94-100 19506755-6 2009 Here we present a model describing the mechanism of allosteric regulation of ADP release from myosin heads as a change, DeltaDeltaG(-D), in the standard free energy for ADP release that results from the work, Deltamicro(mech), performed by that myosin head upon ADP release, or DeltaDeltaG(-D) = Deltamicro(mech). Adenosine Diphosphate 169-172 myosin heavy chain 14 Homo sapiens 245-251 19506755-7 2009 We show that this model is consistent with previous measurements for strain-dependent kinetics of ADP release in both myosin V and muscle myosin II. Adenosine Diphosphate 98-101 myosin heavy chain 14 Homo sapiens 118-124 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 60-63 myosin heavy chain 14 Homo sapiens 121-127 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 102-105 myosin heavy chain 14 Homo sapiens 121-127 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 102-105 myosin heavy chain 14 Homo sapiens 121-127 19346255-1 2009 ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y1 and P2Y12. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 119-123 19527965-0 2009 Lidocaine priming reduces ADP-induced P-selectin expression and platelet-leukocyte aggregation. Adenosine Diphosphate 26-29 selectin P Homo sapiens 38-48 19325141-2 2009 Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) rapidly hydrolyzes ADP to adenosine monophosphate, inhibiting platelet aggregation. Adenosine Diphosphate 78-81 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 0-46 19325141-2 2009 Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) rapidly hydrolyzes ADP to adenosine monophosphate, inhibiting platelet aggregation. Adenosine Diphosphate 78-81 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 48-57 19396049-8 2009 In smokers an increase in PAI-1 level and CT shortening after Coll/Epi and after Coll/ADP were found. Adenosine Diphosphate 86-89 serpin family E member 1 Homo sapiens 26-31 19300046-4 2009 In the healthy volunteers" blood samples stored at 4 degrees C for 6 h, platelet aggregation in response to 1 micromol/l ADP was enhanced, and released levels of soluble form of P-selectin and thromboxane B2 in response to 1 micromol/l ADP markedly increased. Adenosine Diphosphate 236-239 selectin P Homo sapiens 178-188 19192119-10 2009 Platelets from depressed patients were also hyperreactive to adenosine 5 -diphosphate (ADP) stimulation with increased CD62p and CD63 exposure (P=0.003 and 0.019, respectively). Adenosine Diphosphate 61-85 selectin P Homo sapiens 119-124 19192119-10 2009 Platelets from depressed patients were also hyperreactive to adenosine 5 -diphosphate (ADP) stimulation with increased CD62p and CD63 exposure (P=0.003 and 0.019, respectively). Adenosine Diphosphate 61-85 CD63 molecule Homo sapiens 129-133 19192119-10 2009 Platelets from depressed patients were also hyperreactive to adenosine 5 -diphosphate (ADP) stimulation with increased CD62p and CD63 exposure (P=0.003 and 0.019, respectively). Adenosine Diphosphate 87-90 selectin P Homo sapiens 119-124 19192119-10 2009 Platelets from depressed patients were also hyperreactive to adenosine 5 -diphosphate (ADP) stimulation with increased CD62p and CD63 exposure (P=0.003 and 0.019, respectively). Adenosine Diphosphate 87-90 CD63 molecule Homo sapiens 129-133 19192119-11 2009 Six months of treatment resulted in a reduced number of circulating CD62p and CD63 positive platelets (29.84% and 53.38% decrease) and a 20.9% reduction in CD63 exposure after ADP activation. Adenosine Diphosphate 176-179 CD63 molecule Homo sapiens 156-160 19350111-7 2009 ADP-stimulated platelets showed significantly enhanced rolling (but not enhanced firm adhesion) on immobilised EMMPRIN-Fc compared to Fc. Adenosine Diphosphate 0-3 basigin (Ok blood group) Homo sapiens 111-118 19161339-6 2009 We describe the structures of nonphosphorylated MEK1 (npMEK1) binary complexes with ADP and K252a, an ATP-competitive inhibitor (see Table 1), at 1.9 and 2.7 A resolution, respectively. Adenosine Diphosphate 84-87 mitogen-activated protein kinase kinase 1 Homo sapiens 48-52 19161339-7 2009 Ternary complexes have also been solved between npMEK1, a nucleotide, and an allosteric non-ATP competitive inhibitor: ATP-gammaS with compound 1 and ADP with either U0126 or the MEK1 clinical candidate PD325089 at 1.8, 2.0, and 2.5 A, respectively. Adenosine Diphosphate 150-153 mitogen-activated protein kinase kinase 1 Homo sapiens 50-54 19208808-3 2009 Here, we present the crystal structure of the Nup214 N-terminal domain in complex with Ddx19 in its ADP-bound state at 2.5 A resolution. Adenosine Diphosphate 100-103 nucleoporin 214 Homo sapiens 46-52 19208808-3 2009 Here, we present the crystal structure of the Nup214 N-terminal domain in complex with Ddx19 in its ADP-bound state at 2.5 A resolution. Adenosine Diphosphate 100-103 DEAD-box helicase 19B Homo sapiens 87-92 19238144-2 2009 We investigated the correlation between genetic variation of the WDTC1 locus, the ortholog of adp, and human obesity. Adenosine Diphosphate 94-97 WD and tetratricopeptide repeats 1 Homo sapiens 65-70 19166707-7 2009 ADP promotes platelet aggregation by binding to platelet surface receptors P2Y(1) and P2Y(12); the thienopyridines inhibit aggregation by binding covalently to P2Y(12). Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 75-81 19005466-11 2009 These results suggest that GSK-3beta and beta-catenin/TCF pathway might be important in the reciprocal effects between DEX and Li on ADP proliferation and are new targets of therapeutic agents for stress-related disorders. Adenosine Diphosphate 133-136 catenin beta 1 Rattus norvegicus 41-53 19355974-8 2009 Endothelial cells produce and release the two powerful soluble inhibitors of platelet activation, nitric oxide and prostacyclin, and express high levels of CD39 which rapidly metabolises the major platelet feedback agonist, ADP. Adenosine Diphosphate 224-227 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 156-160 19033377-6 2009 We further show that ATP can be hydrolyzed inside the EJC, demonstrating that MAGOH/Y14 acts by locking the conformation of the EJC, so that the release of inorganic phosphate, ADP, and RNA is prevented. Adenosine Diphosphate 177-180 mago homolog, exon junction complex subunit Homo sapiens 78-83 18809618-1 2008 Adenine nucleotide translocase (Ant) is the most abundant protein on the mitochondrial inner membrane (MIM) primarily involved in ADP/ATP exchange. Adenosine Diphosphate 130-133 solute carrier family 25 member 6 Homo sapiens 0-30 18809618-1 2008 Adenine nucleotide translocase (Ant) is the most abundant protein on the mitochondrial inner membrane (MIM) primarily involved in ADP/ATP exchange. Adenosine Diphosphate 130-133 solute carrier family 25 member 6 Homo sapiens 32-35 19061638-3 2008 Here, 3D single-particle reconstructions of Escherichia coli and yeast Hsp90 homologs establish the existence of two distinct nucleotide-stabilized conformations (ATP, ADP) in addition to an apo extended state, supporting previous structural work. Adenosine Diphosphate 168-171 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 71-76 19033201-3 2008 A long-standing puzzle is that in permeabilized cells, adenine nucleotide translocase (ANT) is less accessible to cytosolic ADP than in isolated mitochondria. Adenosine Diphosphate 124-127 solute carrier family 25 member 6 Homo sapiens 55-85 19033201-3 2008 A long-standing puzzle is that in permeabilized cells, adenine nucleotide translocase (ANT) is less accessible to cytosolic ADP than in isolated mitochondria. Adenosine Diphosphate 124-127 solute carrier family 25 member 6 Homo sapiens 87-90 19033201-8 2008 Tubulin added to isolated mitochondria decreases ADP availability to ANT, partially restoring the low MOM permeability (high apparent K(m) for ADP) found in permeabilized cells. Adenosine Diphosphate 49-52 solute carrier family 25 member 6 Homo sapiens 69-72 19012177-2 2008 High post-procedural platelet reactivity to adenosine diphosphate (HPR(ADP)) may be a risk factor for ischemic events after PCI. Adenosine Diphosphate 44-65 WD and tetratricopeptide repeats 1 Homo sapiens 67-75 19132239-5 2008 Plasma leptin levels, but not BMI, were significantly higher in subjects with stronger (above the median) compared to weaker (below the median) platelet aggregation at all ADP concentrations tested. Adenosine Diphosphate 172-175 leptin Homo sapiens 7-13 19132239-6 2008 In further experiments, stimulation (preincubation) with leptin (500 ng/ml) promoted ADP-induced platelet aggregation by approximately 25%, and there was no difference between platelets from obese and those from lean donors regarding the responsiveness to leptin (p = 0.99). Adenosine Diphosphate 85-88 leptin Homo sapiens 57-63 18977227-2 2008 Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. Adenosine Diphosphate 152-155 hemoglobin subunit beta Homo sapiens 68-71 18977227-2 2008 Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. Adenosine Diphosphate 243-246 hemoglobin subunit beta Homo sapiens 68-71 18977227-5 2008 These structural studies provide a detailed mechanism indicating that the binding of ADP-Mg2+ alone may trigger conformational changes in hBB-CK that were not observed with muscle-type-CK. Adenosine Diphosphate 85-88 hemoglobin subunit beta Homo sapiens 138-141 18703513-4 2008 The P2Y(1) receptor stimulated with ADP strongly translocated beta-arrestin-2-YFP, whereas only a slight translocation was observed for beta-arrestin-1-GFP. Adenosine Diphosphate 36-39 purinergic receptor P2Y1 Homo sapiens 4-19 19325727-3 2008 The aim of the present study is to estimate the interaction strength between myosin in nucleotide-free, ATP, ADP.Pi and ADP states and actin monomer. Adenosine Diphosphate 109-112 myosin heavy chain 14 Homo sapiens 77-83 19325727-3 2008 The aim of the present study is to estimate the interaction strength between myosin in nucleotide-free, ATP, ADP.Pi and ADP states and actin monomer. Adenosine Diphosphate 120-123 myosin heavy chain 14 Homo sapiens 77-83 19325727-7 2008 Under these conditions the interaction force between myosin and actin monomer decreases from 0.83 nN in the nucleotide-free state to 0.27 nN in the ATP state, and increases to 0.60 nN after ATP hydrolysis and Pi release from the complex (ADP state). Adenosine Diphosphate 238-241 myosin heavy chain 14 Homo sapiens 53-59 18614813-8 2008 The slope of nu(max) versus [MgADP] was significantly greater for tonic (-0.51+/-0.04) than phasic muscle myosin (-0.15+/-0.04), demonstrating the greater MgADP affinity of myosin from tonic muscle. Adenosine Diphosphate 29-34 myosin heavy chain 14 Homo sapiens 106-112 18719126-6 2008 We find that with the fusion proteins, MuB-dependent target delivery occurs efficiently under conditions where ATP hydrolysis is prevented by mutation or use of ADP. Adenosine Diphosphate 161-164 ubiquitin like 3 Homo sapiens 39-42 18513210-1 2008 BACKGROUND: Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors (GPCRs), the P2Y(1) and P2Y(12) purinergic receptors. Adenosine Diphosphate 12-33 purinergic receptor P2Y1 Homo sapiens 163-169 18513210-1 2008 BACKGROUND: Adenosine diphosphate (ADP) is a critical regulator of platelet activation, mediating its actions through two G protein-coupled receptors (GPCRs), the P2Y(1) and P2Y(12) purinergic receptors. Adenosine Diphosphate 35-38 purinergic receptor P2Y1 Homo sapiens 163-169 18471985-0 2008 HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion. Adenosine Diphosphate 41-44 heat shock protein family B (small) member 1 Homo sapiens 0-5 18471985-2 2008 ADP has been reported to induce heat-shock protein (HSP) 27 phosphorylation in human platelets. Adenosine Diphosphate 0-3 heat shock protein family B (small) member 1 Homo sapiens 32-59 18471985-4 2008 In the present study, we investigated the mechanisms and the roles of ADP-induced HSP27 phosphorylation in human platelets. Adenosine Diphosphate 70-73 heat shock protein family B (small) member 1 Homo sapiens 82-87 18471985-7 2008 These results strongly suggest that the ADP-induced phosphorylation of HSP27 via p44/p42 MAPK and/or p38 MAPK is therefore sufficient for platelet granule secretion but not for platelet aggregation in humans. Adenosine Diphosphate 40-43 heat shock protein family B (small) member 1 Homo sapiens 71-76 18485086-5 2008 METHODS: The effects of cangrelor and the active metabolites of clopidogrel (C-AM) and prasugrel (P-AM) on platelet function were assessed by ADP-induced platelet P-selectin expression in whole blood. Adenosine Diphosphate 142-145 selectin P Homo sapiens 163-173 18552179-1 2008 Myosin is an actin-based motor protein that generates force by cycling between actin-attached (strong binding: ADP or rigor) and actin-detached (weak binding: ATP or ADP.P(i)) states during its ATPase cycle. Adenosine Diphosphate 111-114 myosin heavy chain 14 Homo sapiens 0-6 18552179-1 2008 Myosin is an actin-based motor protein that generates force by cycling between actin-attached (strong binding: ADP or rigor) and actin-detached (weak binding: ATP or ADP.P(i)) states during its ATPase cycle. Adenosine Diphosphate 166-169 myosin heavy chain 14 Homo sapiens 0-6 18405981-7 2008 The individual physiologic agonists ADP, collagen and epinephrine increased LPAs, CD62P and CAP1 binding only modestly. Adenosine Diphosphate 36-39 adenylyl cyclase-associated protein 1 Canis lupus familiaris 92-96 18522758-1 2008 BACKGROUND: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. Adenosine Diphosphate 158-161 solute carrier family 25 member 6 Homo sapiens 12-42 18522758-1 2008 BACKGROUND: Adenine nucleotide translocase (ANT) is located in the inner mitochondrial membrane and catalyzes the exchange of mitochondrial ATP for cytosolic ADP. Adenosine Diphosphate 158-161 solute carrier family 25 member 6 Homo sapiens 44-47 18445527-1 2008 The P2Y(1) and P2Y(12) purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Adenosine Diphosphate 74-95 purinergic receptor P2Y1 Homo sapiens 4-10 18445527-1 2008 The P2Y(1) and P2Y(12) purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Adenosine Diphosphate 97-100 purinergic receptor P2Y1 Homo sapiens 4-10 18421459-5 2008 They suggest that Sls1 regulates this interaction, by stimulating the conversion of BiP from the ADP-bound to the ATP-bound state, which favors its interaction with Ire1. Adenosine Diphosphate 97-100 Sls1p Saccharomyces cerevisiae S288C 18-22 18406329-0 2008 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Adenosine Diphosphate 88-91 SPT16 homolog, facilitates chromatin remodeling subunit Homo sapiens 108-113 18094327-6 2008 SG-/- platelets had reduced ability to aggregate in response to low concentrations of collagen or PAR4 thrombin receptor agonist AYPGKF, and reduced fibrinogen binding after AYPGKF, but aggregated normally to ADP. Adenosine Diphosphate 209-212 serglycin Mus musculus 0-2 18186520-5 2008 This indicates that the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP and that deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol. Adenosine Diphosphate 157-160 sedoheptulokinase Homo sapiens 24-29 18186520-5 2008 This indicates that the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP and that deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol. Adenosine Diphosphate 157-160 sedoheptulokinase Homo sapiens 47-64 18186520-5 2008 This indicates that the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP and that deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol. Adenosine Diphosphate 157-160 sedoheptulokinase Homo sapiens 66-69 18409530-5 2008 AMPD regulates important purine nucleotides including ATP, ADP, AMP, IMP et al. Adenosine Diphosphate 59-62 adenosine monophosphate deaminase 1 Homo sapiens 0-4 18201966-9 2008 Kinetic simulations reveal that the high ADP affinity of actomyosin Vc may lead to elevations of the duty ratio of myosin Vc to as high as 64% under possible physiological ADP concentrations. Adenosine Diphosphate 41-44 myosin VC Homo sapiens 61-70 18201966-9 2008 Kinetic simulations reveal that the high ADP affinity of actomyosin Vc may lead to elevations of the duty ratio of myosin Vc to as high as 64% under possible physiological ADP concentrations. Adenosine Diphosphate 172-175 myosin VC Homo sapiens 61-70 18297551-5 2008 It inhibited platelet shape change and Ca2+ mobilization brought about by ADP (but not other agonists) indicating antagonism at P2Y(1) receptors, and also inhibited ADP-induced P-selectin expression. Adenosine Diphosphate 165-168 selectin P Homo sapiens 177-187 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 ribosomal protein S6 kinase A1 Homo sapiens 39-45 18174464-10 2008 We conclude that ADP promotes human endothelial cell migration by activating P2Y1 receptor-mediated MAPK pathways, possibly contributing to reendothelialization and angiogenesis after vascular injury. Adenosine Diphosphate 17-20 purinergic receptor P2Y1 Homo sapiens 77-90 18305394-4 2008 The concentrations of ATP, ATP-gammaS, ADP, and ADP-betaS that showed maximal IL-10 release were 100, 10, 100, and 100 microM respectively. Adenosine Diphosphate 39-42 interleukin 10 Rattus norvegicus 78-83 18305394-7 2008 Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca(2+) release and/or cAMP-activated PKA were the main contributors to extracellular ATP-(or ADP)-mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 (a P2Y(1) antagonist) or 5"-AMPS (a P2Y(11) antagonist), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression. Adenosine Diphosphate 193-196 interleukin 10 Rattus norvegicus 207-212 18305394-7 2008 Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca(2+) release and/or cAMP-activated PKA were the main contributors to extracellular ATP-(or ADP)-mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 (a P2Y(1) antagonist) or 5"-AMPS (a P2Y(11) antagonist), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression. Adenosine Diphosphate 193-196 interleukin 10 Rattus norvegicus 229-234 18305394-7 2008 Further, we obtained evidence of crosstalk between P2 receptors, in a situation where intracellular Ca(2+) release and/or cAMP-activated PKA were the main contributors to extracellular ATP-(or ADP)-mediated IL-10 expression, and IL-10 production was down-regulated by either MRS2179 (a P2Y(1) antagonist) or 5"-AMPS (a P2Y(11) antagonist), indicating that both the P2Y(1) and P2Y(11) receptors are major receptors involved in IL-10 expression. Adenosine Diphosphate 193-196 interleukin 10 Rattus norvegicus 229-234 18380807-3 2008 The dissociation was induced in the presence of 10 mM ATP, indicating that the ADP-binding form of HSC73 might be associated with TAP. Adenosine Diphosphate 79-82 filamin B Homo sapiens 130-133 18162585-7 2008 From this analysis, we conclude that AMK2 is the major activity for equilibration of adenylates and de novo synthesis of ADP in the plastid stroma. Adenosine Diphosphate 121-124 adenosine monophosphate kinase Arabidopsis thaliana 37-41 18231939-0 2008 Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Adenosine Diphosphate 69-72 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 17-21 18231939-0 2008 Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Adenosine Diphosphate 112-115 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 17-21 18231939-3 2008 Here we have investigated the association between ADP-induced platelet aggregation, ADP metabolism and expression of ecto-NTPDase CD39 on leucocytes in patients with leucocytosis. Adenosine Diphosphate 50-53 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 130-134 18231939-12 2008 For two patients with very high CD39FI (60,000 cf 1500 for controls) ADP-induced aggregation was abolished. Adenosine Diphosphate 69-72 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 32-36 18231939-14 2008 It is concluded that ADP-induced platelet aggregation in leucocytosis is reduced as a result of enhanced ADP metabolism due to raised levels of leucocyte-associated CD39. Adenosine Diphosphate 21-24 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 165-169 18037705-6 2008 By contrast to the mechanism of Kinesin-1, microtubule association triggers ADP release from both motor domains of Eg5. Adenosine Diphosphate 76-79 kinesin family member 11 Homo sapiens 115-118 17914025-5 2008 Akt1 and Akt2 play important roles in early GPIb-IX signaling independent of Syk, adenosine diphosphate (ADP), or thromboxane A2 (TXA2), in addition to their recognized roles in ADP- and TXA2-dependent secondary amplification pathways. Adenosine Diphosphate 178-181 AKT serine/threonine kinase 2 Homo sapiens 9-13 17630652-4 2008 The following parameters were quantified by cytometry after stimulation with adenosine diphosphate (ADP) (0.5, 1, 2, 5, 10, 20 muM): CD62P (P-selectin) and PAC-1 expression, and cytosolic Ca(2+) mobilization. Adenosine Diphosphate 100-103 selectin P Homo sapiens 133-138 17630652-15 2008 CONCLUSIONS: Tight relationships between aggregation and cytometric quantification of platelet markers in whole blood, in particular CD62P, allow to predict aggregation response to ADP from flow data in patients treated with aspirin alone or with aspirin plus clopidogrel. Adenosine Diphosphate 181-184 selectin P Homo sapiens 133-138 19039672-5 2008 According to a traditional model, catch is due to slower cross-bridge cycles where myosin heads remain longer attached to the actin filaments after force generation, possibly caused by a hindered release of ADP from the myosin heads. Adenosine Diphosphate 207-210 myosin heavy chain 14 Homo sapiens 83-89 19039672-5 2008 According to a traditional model, catch is due to slower cross-bridge cycles where myosin heads remain longer attached to the actin filaments after force generation, possibly caused by a hindered release of ADP from the myosin heads. Adenosine Diphosphate 207-210 myosin heavy chain 14 Homo sapiens 220-226 19544670-2 2008 Incubation of the partially purified NDPK-B (Nm23-H2 by Western blot) from [gamma32P]Pi-labeled cells with non-radioactive ADP results in the formation of [gamma32P]ATP (Proc. Adenosine Diphosphate 123-126 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 37-43 19544670-2 2008 Incubation of the partially purified NDPK-B (Nm23-H2 by Western blot) from [gamma32P]Pi-labeled cells with non-radioactive ADP results in the formation of [gamma32P]ATP (Proc. Adenosine Diphosphate 123-126 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 45-52 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 77-98 selectin P Homo sapiens 138-143 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 77-98 CD63 molecule Homo sapiens 145-149 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 100-103 selectin P Homo sapiens 138-143 18217151-7 2008 Platelet function was assessed by optical aggregometry and flow cytometry of adenosine diphosphate (ADP)-stimulated surface expression of CD62P, CD63 and PAC-1 before clopidogrel and immediately before CA. Adenosine Diphosphate 100-103 CD63 molecule Homo sapiens 145-149 18057028-2 2007 One of the most ubiquitous GPCRs is the P2Y(1) receptor (P2RY1, hereafter referred to as P2Y(1)R) for extracellular nucleotides, mainly ADP. Adenosine Diphosphate 136-139 purinergic receptor P2Y1 Homo sapiens 40-55 18057028-2 2007 One of the most ubiquitous GPCRs is the P2Y(1) receptor (P2RY1, hereafter referred to as P2Y(1)R) for extracellular nucleotides, mainly ADP. Adenosine Diphosphate 136-139 purinergic receptor P2Y1 Homo sapiens 57-62 27263955-11 2007 According to mean fluorescence intensity with ADP induction, an increased expression of CD61+, CD61+/CD41+ and CD62P+ in PlA1/A2 platelets were detected as compared to the group carrying the wild type (p< 0.0001, p= 0.006, p= 0.0001), respectively. Adenosine Diphosphate 46-49 POU class 2 homeobox 3 Homo sapiens 121-125 17766683-1 2007 Poly(ADP-ribose)polymerases (PARP-1 and -2) are activated by DNA strand breaks to synthesize protein-bound ADP-ribose polymers from NAD+. Adenosine Diphosphate 5-8 poly (ADP-ribose) polymerase 1 Rattus norvegicus 29-42 18021939-1 2007 Adenine nucleotide translocase (ANT) facilitates the exchange of extramitochondrial adenosine diphosphate and intramitochondrial adenosine triphosphate across the inner mitochondrial membrane and appears to be a member of the mitochondrial permeability transition pore whose opening induces apoptosis. Adenosine Diphosphate 84-105 solute carrier family 25 member 6 Homo sapiens 0-30 18021939-1 2007 Adenine nucleotide translocase (ANT) facilitates the exchange of extramitochondrial adenosine diphosphate and intramitochondrial adenosine triphosphate across the inner mitochondrial membrane and appears to be a member of the mitochondrial permeability transition pore whose opening induces apoptosis. Adenosine Diphosphate 84-105 solute carrier family 25 member 6 Homo sapiens 32-35 17978573-2 2007 The HSP90 inhibitor geldanamycin (GA) occupies the ATP/ADP binding pocket of HSP90 so inhibits its chaperone activity and causes subsequent degradation of HSP90 client proteins by proteasomes. Adenosine Diphosphate 55-58 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 17978573-2 2007 The HSP90 inhibitor geldanamycin (GA) occupies the ATP/ADP binding pocket of HSP90 so inhibits its chaperone activity and causes subsequent degradation of HSP90 client proteins by proteasomes. Adenosine Diphosphate 55-58 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 17978573-2 2007 The HSP90 inhibitor geldanamycin (GA) occupies the ATP/ADP binding pocket of HSP90 so inhibits its chaperone activity and causes subsequent degradation of HSP90 client proteins by proteasomes. Adenosine Diphosphate 55-58 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-82 17767906-7 2007 ADP may elicit these anti-adipogenic functions by regulating chromatin dynamics and gene transcription, as it binds both histones and HDAC3 and inhibits PPARgamma activity. Adenosine Diphosphate 0-3 histone deacetylase 3 Mus musculus 134-139 17761891-2 2007 Impairment of adenine nucleotide translocase-1 (ANT-1) gene, the main mitochondrial ADP/ATP exchanger, leads to cardiac hypertrophy. Adenosine Diphosphate 84-87 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 14-46 17761891-2 2007 Impairment of adenine nucleotide translocase-1 (ANT-1) gene, the main mitochondrial ADP/ATP exchanger, leads to cardiac hypertrophy. Adenosine Diphosphate 84-87 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 48-53 17826235-5 2007 Patients with SLI compared with IC had significantly enhanced ADP stimulated P-selectin expression (median 42.45% [inter-quartile range 33.32% to 58.5%] vs 35.2% [26.07% to 46.32%], P = .002) and bound fibrinogen (73.7% [54.3% to 83.2%] vs 63.7% [43.8% to 76.5%], P = .001). Adenosine Diphosphate 62-65 selectin P Homo sapiens 77-87 17826235-7 2007 An ankle-brachial pressure index (ABPI) of less than 0.6 was associated with increased ADP stimulated P-selectin and bound fibrinogen (P < .05). Adenosine Diphosphate 87-90 selectin P Homo sapiens 102-133 17826235-8 2007 ABPI correlated inversely with ADP stimulated P-selectin expression (r = -0.228, P = .003), ADP stimulated fibrinogen binding (r = -0.156, P = .043) and TRAP stimulated aggregation (r = -0.179, P = .04). Adenosine Diphosphate 31-34 selectin P Homo sapiens 46-56 17560607-3 2007 The nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), also known as CD39, is a plasma membrane-bound ectoenzyme that hydrolyzes extracellular ATP and ADP to AMP. Adenosine Diphosphate 157-160 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 4-48 17538025-2 2007 Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. Adenosine Diphosphate 36-39 C-terminal binding protein 1 Mus musculus 169-174 17538025-2 2007 Here, we present evidence that mono-ADP-ribosylation of the transcriptional corepressor C terminal binding protein, brefeldin A (BFA)-induced ADP-ribosylated substrate (CtBP1/BARS) regulates neutral lipid storage in droplets that are surrounded by a monolayer of phospholipid and associated proteins. Adenosine Diphosphate 36-39 C-terminal binding protein 1 Mus musculus 175-179 17721621-7 2007 Platelet activation marker expression (CD62P and activated alphaIIbbeta3) induced by ADP or TRAP was lower after CPB than before CPB, suggesting a deleterious effect of normothermic CPB on platelet function. Adenosine Diphosphate 85-88 selectin P Homo sapiens 39-44 17468160-2 2007 The kinetic parameters of myosin cross-bridge turnover in permeabilized catch muscle, and how they are potentially modified by the catch mechanism, were determined by single turnover measurements on myosin-bound ADP. Adenosine Diphosphate 212-215 myosin heavy chain 14 Homo sapiens 26-32 17468160-6 2007 The only effects of the catch link on myosin-bound ADP turnover are 1), a small, very slow extra turnover when catch force is maintained at very low [Ca+2] (pCa > 8); and 2), attenuation of the shortening-induced increase in turnover at subsaturating [Ca(+2)]. Adenosine Diphosphate 51-54 myosin heavy chain 14 Homo sapiens 38-44 17507377-6 2007 Functional analyses revealed that the doubly mutated chimeric enzymes almost completely acquired most of the different regulatory preferences between hGDH1 and hGDH2 for electrophoretic mobility, heat-stability, ADP activation, palmitoyl-CoA inhibition, and l-leucine activation, except for GTP inhibition. Adenosine Diphosphate 212-215 glutamate dehydrogenase 1 Homo sapiens 150-155 17625661-7 2007 After ADP addition, the O2 consumption rate (S3) in the 1d group remained similar to the CTR rate (ANOVA p > .05), while the RC rate was reduced (ANOVA, p = 0.001) vs. CTR. Adenosine Diphosphate 6-9 calcitonin receptor Rattus norvegicus 171-174 17298299-1 2007 We have previously shown that ADP-induced thromboxane generation in platelets requires signalling events from the G(q)-coupled P2Y1 receptor (platelet ADP receptor coupled to stimulation of phospholipase C) and the G(i)-coupled P2Y12 receptor (platelet ADP receptor coupled to inhibition of adenylate cyclase) in addition to outside-in signalling. Adenosine Diphosphate 30-33 purinergic receptor P2Y1 Homo sapiens 127-140 17298299-5 2007 However, blockade of either P2Y1 or the P2Y12 receptors with corresponding antagonists completely abolished ERK phosphorylation, indicating that both P2Y receptors are required for ADP-induced ERK activation. Adenosine Diphosphate 181-184 purinergic receptor P2Y1 Homo sapiens 28-32 17473574-8 2007 Parameters of platelet activation (glycoprotein IIb/IIIa and P-selectin surface expression) were significantly higher in ACS patients at baseline and after 5 and 20 micromol/l ADP stimulation (P < 0.0001). Adenosine Diphosphate 176-179 selectin P Homo sapiens 61-71 18404433-0 2007 Residual platelet ADP reactivity after clopidogrel treatment is dependent on activation of both the unblocked P2Y(1) and the P2Y (12) receptor and is correlated with protein expression of P2Y (12). Adenosine Diphosphate 18-21 purinergic receptor P2Y1 Homo sapiens 110-116 17317746-7 2007 Thus, our data present evidence for a dendritic segregation of Kv1-like channels in CA1 pyramidal neurons and identify a novel action for these channels, showing that they inhibit action potential bursting by restricting the size of the ADP. Adenosine Diphosphate 237-240 carbonic anhydrase 1 Rattus norvegicus 84-87 17351663-6 2007 ADP, a natural ligand for P2Y(1) receptors, induced muscular relaxation, antagonized by MRS 2179 and by TTX or L-NAME. Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 26-32 17261271-0 2007 Activation of NUDT5, an ADP-ribose pyrophosphatase, by nitric oxide-mediated ADP-ribosylation. Adenosine Diphosphate 24-27 nudix hydrolase 5 Homo sapiens 14-19 17261271-3 2007 Here, we show that NO stimulates nonenzymatic ADP-ribosylation of NUDT5 using ADP-ribose and consequently activates its ADPRase activity. Adenosine Diphosphate 46-49 nudix hydrolase 5 Homo sapiens 66-71 17261271-6 2007 Using recombinant human NUDT5, we also demonstrated that the increase of ADPRase activity is mediated via ADP-ribosylation at cysteine residue(s) in the presence of reductant. Adenosine Diphosphate 73-76 nudix hydrolase 5 Homo sapiens 24-29 17261271-7 2007 This result suggests that NO activates NUDT5 through ADP-ribosylation at cysteine residues of the enzyme in macrophages. Adenosine Diphosphate 53-56 nudix hydrolase 5 Homo sapiens 39-44 17142278-3 2007 When a laser trap was used to apply load to single heads of expressed smooth muscle myosin (S1), the ADP release kinetics accelerated with an assistive load and slowed with a resistive load; however, ATP binding was mostly unaffected. Adenosine Diphosphate 101-104 myosin heavy chain 14 Homo sapiens 84-90 17397263-5 2007 We also determined the structure of AvrB in complex with adenosine diphosphate bound in a binding pocket adjacent to the RIN4 binding domain. Adenosine Diphosphate 57-78 RPM1 interacting protein 4 Arabidopsis thaliana 121-125 17279620-7 2007 An ion-pair interaction in the AAC thought to be central to the mechanism of membrane penetration by ADP is predicted by this homology model to be replaced by a pi-cation interaction in MFT orthologues and probably also in other members of the family bearing the P(I/L)W motif. Adenosine Diphosphate 101-104 solute carrier family 25 member 4 Bos taurus 31-34 17665640-0 2007 Endogenous ADP-ribosylation of eukaryotic elongation factor 2 and its 32 kDa tryptic fragment. Adenosine Diphosphate 11-14 eukaryotic translation elongation factor 2 Homo sapiens 31-61 17665640-2 2007 The binding of free ADP-ribose and endogenous transferase-dependent ADP-ribosylation were distinct reactions for eEF-2, as indicated by different findings. Adenosine Diphosphate 20-23 eukaryotic translation elongation factor 2 Homo sapiens 113-118 17665640-2 2007 The binding of free ADP-ribose and endogenous transferase-dependent ADP-ribosylation were distinct reactions for eEF-2, as indicated by different findings. Adenosine Diphosphate 68-71 eukaryotic translation elongation factor 2 Homo sapiens 113-118 17665640-3 2007 Incubation of eEF-2 tryptic fragment 32/33 kDa (32F) with NAD was ADP-ribosylated and gave rise to the covalent binding of ADP-ribose to eEF-2. Adenosine Diphosphate 66-69 eukaryotic translation elongation factor 2 Homo sapiens 14-19 17665640-3 2007 Incubation of eEF-2 tryptic fragment 32/33 kDa (32F) with NAD was ADP-ribosylated and gave rise to the covalent binding of ADP-ribose to eEF-2. Adenosine Diphosphate 66-69 eukaryotic translation elongation factor 2 Homo sapiens 137-142 17986831-5 2007 Autosomal dominant mutations in the genes encoding glucokinase (GCK) and glutamate dehydrogenase (GLUD1) lead to inappropriate insulin secretion by increasing the ATP/ADP ratio in the Beta-cells. Adenosine Diphosphate 167-170 glutamate dehydrogenase 1 Homo sapiens 98-103 17187456-1 2007 Platelets possess three P2 receptors for adenine nucleotides: P2Y1 and P2Y12, which interact with ADP, and P2X1, which interacts with ATP. Adenosine Diphosphate 98-101 purinergic receptor P2Y1 Homo sapiens 62-66 16563469-4 2007 ADP is used to maximally activate the platelets by binding to the P2Y1 and P2Y12 platelet receptors, while PGE1 is used to suppress the ADP-induced P2Y1-mediated increase in intracellular calcium levels. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 66-70 16563469-4 2007 ADP is used to maximally activate the platelets by binding to the P2Y1 and P2Y12 platelet receptors, while PGE1 is used to suppress the ADP-induced P2Y1-mediated increase in intracellular calcium levels. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 75-79 17555802-1 2007 INTRODUCTION: CD39/NTPDase-1 is a cell surface enzyme expressed on leukocytes and endothelial cells that metabolizes ATP to ADP and AMP. Adenosine Diphosphate 124-127 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 14-18 17555802-1 2007 INTRODUCTION: CD39/NTPDase-1 is a cell surface enzyme expressed on leukocytes and endothelial cells that metabolizes ATP to ADP and AMP. Adenosine Diphosphate 124-127 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 19-28 17050532-5 2006 To investigate the structural basis for substrate specificity, we have determined the crystal structure of the yeast inositol phosphate multikinase Ipk2 in the apoform and in a complex with ADP and Mn(2+) at up to 2.0A resolution. Adenosine Diphosphate 190-193 inositol polyphosphate multikinase Saccharomyces cerevisiae S288C 148-152 17161243-4 2006 Platelet aggregation (5 and 20 muM adenosine diphosphate [ADP]), ADP-stimulated expression of active glycoprotein (GP) IIb/IIIa, and platelet-bound P-selectin, tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), and cardiac markers were measured. Adenosine Diphosphate 65-68 selectin P Homo sapiens 148-158 17127486-9 2006 Upon stimulation with ADP and SFLLRN, monocyte-platelet and neutrophil-platelet aggregates, platelet CD40L and P-selectin, and monocyte TF increased compared to the resting state but was not different between 0 and 24 h, indicating that the responsiveness to those agonists was not altered. Adenosine Diphosphate 22-25 selectin P Homo sapiens 111-121 17059469-5 2006 ADP acts through two G protein-coupled receptors, the Gq-coupled P2Y1 receptor, and the Gi-coupled P2Y12 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 65-78 17059469-9 2006 Furthermore, costimulation of both P2Y1 and P2Y12 receptors is required for ADP-induced platelet aggregation. Adenosine Diphosphate 76-79 purinergic receptor P2Y1 Homo sapiens 35-39 18404463-6 2006 The involvement of P2Y12 receptors in Ca2+ responses induced by adenine nucleotides was confirmed by the pharmacological and pertussis toxin sensitivity of the response induced by adenosine diphosphate (ADP). Adenosine Diphosphate 180-201 purinergic receptor P2Y12 Rattus norvegicus 19-24 18404463-6 2006 The involvement of P2Y12 receptors in Ca2+ responses induced by adenine nucleotides was confirmed by the pharmacological and pertussis toxin sensitivity of the response induced by adenosine diphosphate (ADP). Adenosine Diphosphate 203-206 purinergic receptor P2Y12 Rattus norvegicus 19-24 16934758-0 2006 Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. Adenosine Diphosphate 50-53 purinergic receptor P2Y1 Homo sapiens 65-69 16934758-1 2006 ADP is the endogenous agonist for both P2Y(1) and P2Y(12) receptors, which are important therapeutic targets. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 39-45 16934758-2 2006 It was previously demonstrated that ADP and a synthetic agonist, 2-methylthioadenosine 5"-diphosphate (2MeSADP), can induce apoptosis by activating the human P2Y(1) receptor heterologously expressed in astrocytoma cells. Adenosine Diphosphate 36-39 purinergic receptor P2Y1 Homo sapiens 158-173 17015823-0 2006 The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Adenosine Diphosphate 23-26 ADP-ribosylserine hydrolase Homo sapiens 47-51 16987338-9 2006 HES200/0.5 and HES130/0.4 reduced the CD42b, CD41/61 and CD62p expression of ADP-agonist-activated platelets at 15 min after intravenous infusion. Adenosine Diphosphate 77-80 selectin P Homo sapiens 57-62 16959573-8 2006 These results indicate that SIRT4 functions in beta cell mitochondria to repress the activity of GDH by ADP-ribosylation, thereby downregulating insulin secretion in response to amino acids, effects that are alleviated during CR. Adenosine Diphosphate 104-107 sirtuin 4 Mus musculus 28-33 16860276-5 2006 Identification of mitochondrial uncoupling proteins UCP allowed further understanding of the mechanism of coupling or uncoupling of respiration to ADP phosphorylation. Adenosine Diphosphate 147-150 uncoupling protein 1 Homo sapiens 52-55 16142694-0 2006 Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions. Adenosine Diphosphate 11-14 eukaryotic translation elongation factor 2 Homo sapiens 43-62 16627471-14 2006 We conclude that ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease. Adenosine Diphosphate 17-20 HNP1 Homo sapiens 37-42 16752921-10 2006 In contrast to the chicken E-NTPDase 8, the human E-NTPDase 8 hydrolyzes MgADP poorly and is inhibited by several detergents as well as benzyl alcohol; the latter attribute may be related to weaker interaction of the transmembranous domains of the human E-NTPDase 8. Adenosine Diphosphate 73-78 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 50-61 16752921-10 2006 In contrast to the chicken E-NTPDase 8, the human E-NTPDase 8 hydrolyzes MgADP poorly and is inhibited by several detergents as well as benzyl alcohol; the latter attribute may be related to weaker interaction of the transmembranous domains of the human E-NTPDase 8. Adenosine Diphosphate 73-78 ectonucleoside triphosphate diphosphohydrolase 8 Homo sapiens 50-61 16368572-3 2006 It is well established that ADP activates platelets through 3 purinergic receptors, namely P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 28-31 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 91-95 16368572-3 2006 It is well established that ADP activates platelets through 3 purinergic receptors, namely P2Y1, P2Y12 and P2X1. Adenosine Diphosphate 28-31 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 97-102 16469333-4 2006 The gamma-phosphate of ATP participates in several charge-charge interactions consistent with the preference of gelsolin for ATP, as a binding partner, over ADP. Adenosine Diphosphate 157-160 gelsolin Homo sapiens 112-120 16278104-4 2006 Using S1 preparations cleaved with elastase, we could show that the residue of 567-578 loop that can be cross-linked to actin in the presence of MgADP.AlF4 is Lys-574. Adenosine Diphosphate 145-150 actin Oryctolagus cuniculus 120-125 16433710-5 2006 RESULTS: Adenosine diphosphate (ADP)-induced platelet P-selectin expression increased post-meal in Type 2 diabetic patients both at baseline and after treatment with repaglinide and glibenclamide (P < 0.01 for all; repeated measures anova). Adenosine Diphosphate 9-30 selectin P Homo sapiens 54-64 16433710-5 2006 RESULTS: Adenosine diphosphate (ADP)-induced platelet P-selectin expression increased post-meal in Type 2 diabetic patients both at baseline and after treatment with repaglinide and glibenclamide (P < 0.01 for all; repeated measures anova). Adenosine Diphosphate 32-35 selectin P Homo sapiens 54-64 16433710-6 2006 Repaglinide treatment reduced fasting ADP-induced P-selectin expression compared with baseline (P = 0.01), but did not influence meal-induced platelet hyper-reactivity (P = 0.32). Adenosine Diphosphate 38-41 selectin P Homo sapiens 50-60 16234484-2 2006 Both P2Y(1) and P2Y(12) are ADP receptors on human platelets and are essential for ADP-induced platelet aggregation that plays pivotal roles in thrombosis and hemostasis. Adenosine Diphosphate 28-31 purinergic receptor P2Y1 Homo sapiens 5-11 16228296-6 2005 Since it is known that ADP stimulates the PI3K and calcium signal primarily through P2Y12 and P2Y1 receptors respectively, our data indicated that integrin alpha(IIb)beta3 downstream PI3K and calcium activation might be not completely coupled to integrin associated signaling complex, but in part through feedback stimulation by granular released ADP. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 84-88 16148004-4 2005 Interestingly, we show that SOX6 is expressed in adult pancreatic insulin-producing beta-cells and that overexpression of SOX6 decreased glucose-stimulated insulin secretion, which was accompanied by decreased ATP/ADP ratio, Ca(2+) mobilization, proinsulin content, and insulin gene expression. Adenosine Diphosphate 214-217 SRY (sex determining region Y)-box 6 Mus musculus 122-126 16236603-1 2005 ADP activates human platelets through two G-protein coupled receptors, P2Y1 and P2Y12, to induce a range of functional responses. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 71-75 16236603-6 2005 However, by assessment of phosphorylation of its major substrate myosin light chain phosphatase, we provide direct evidence for activation of Rho kinase by ADP, and that although P2Y1 is required for activation of Rho kinase, P2Y12 is able to potentiate its activity. Adenosine Diphosphate 156-159 myosin heavy chain 14 Homo sapiens 65-71 16236603-7 2005 We conclude that P2Y12 plays a potentiatory role in ADP-induced shape change through regulation of the Rho kinase pathway, potentiating both myosin phosphorylation and actin polymerisation, and this forms part of an important signalling pathway additional to its well-established Gi-coupled pathways. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 141-147 15863506-2 2005 In this work, we found that TPO was able to restore ADP-induced platelet aggregation upon blockade of the G(q)-coupled P2Y1 purinergic receptor but not upon inhibition of the G(i)-coupled P2Y12 receptor. Adenosine Diphosphate 52-55 purinergic receptor P2Y1 Homo sapiens 119-123 15863506-6 2005 However, ADP-induced activation of integrin alpha(IIb)beta(3) was blocked by antagonists of the G(q)-coupled P2Y1 receptor but was completely restored by the simultaneous co-stimulation of cMpl receptor by TPO. Adenosine Diphosphate 9-12 purinergic receptor P2Y1 Homo sapiens 109-122 15863506-11 2005 In ADP-stimulated platelets, Rap1B activation was reduced, although not abolished, upon blockade of the P2Y1 receptor. Adenosine Diphosphate 3-6 purinergic receptor P2Y1 Homo sapiens 104-117 15689408-6 2005 By approximately 40 contractions, ADP was clearly visible in AK1(-/-) muscle. Adenosine Diphosphate 34-37 adenylate kinase 1 Mus musculus 61-64 18404504-6 2005 In contrast, NTPDases 2, 3 and 8 are expected to promote the activation of ADP specific receptors, because in the presence of ATP they produce a sustained (NTPDase2) or transient (NTPDases 3 and 8) accumulation of ADP. Adenosine Diphosphate 75-78 ectonucleoside triphosphate diphosphohydrolase 3 Homo sapiens 180-196 15972140-1 2005 To investigate the changes of platelet activated state and platelet activated function by trace whole blood flow cytometry (FCM), and to explore the mechanism of hemorrhage and infiltration in adults with acute leukemia, the expression percentage and changes of these expressions of CD62p and PAC-1 on platelet surface were determined by FCM of trace whole blood after platelet activated by ADP in patients with new diagnosed AL (group I), complete remission (CR, group II) and continuously complete remission (CCR, group III). Adenosine Diphosphate 391-394 selectin P Homo sapiens 283-288 15972140-3 2005 The result showed that the expression of CD62p in group I and II was higher than that in control group, before and after platelet activated by ADP (P < 0.01). Adenosine Diphosphate 143-146 selectin P Homo sapiens 41-46 15972140-5 2005 After platelet activated by ADP, the expression of PAC-1 in the former was lower than that in the latter (P < 0.01). Adenosine Diphosphate 28-31 ADCYAP receptor type I Homo sapiens 51-56 15816504-1 2005 The dual role of P2Y1 and P2Y12 receptors in platelet aggregation by ADP has been firmly established, based on the action of selective inhibitors, gene targeting in mice and human genetic evidence. Adenosine Diphosphate 69-72 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 17-21 15816504-1 2005 The dual role of P2Y1 and P2Y12 receptors in platelet aggregation by ADP has been firmly established, based on the action of selective inhibitors, gene targeting in mice and human genetic evidence. Adenosine Diphosphate 69-72 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 26-31 15381153-0 2005 Effect of oxidative stress on in vivo ADP-ribosylation of eukaryotic elongation factor 2. Adenosine Diphosphate 38-41 eukaryotic translation elongation factor 2 Homo sapiens 58-88 15381153-3 2005 In order to address this issue we investigated the in vivo ADP-ribosylation of eEF2 and the effect of oxidative stress thereon. Adenosine Diphosphate 59-62 eukaryotic translation elongation factor 2 Homo sapiens 79-83 15935828-13 2005 Increased generation of prothrombotic ADP in these patients implies a potential benefit from therapeutic intervention with soluble forms of CD39. Adenosine Diphosphate 38-41 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 140-144 15935833-6 2005 Platelet P-selectin expression was not affected by extracellular [Ca(2+)], except mild increases of ADP-induced platelet P-selectin expression in the presence of EDTA. Adenosine Diphosphate 100-103 selectin P Homo sapiens 121-131 15647161-3 2004 In the normal adenosine triphosphate cycle, myosin.adenosine diphosphate.phosphate (M.ADP.Pi) binds to actin and moves it by ca. Adenosine Diphosphate 51-72 myosin heavy chain 14 Homo sapiens 44-50 15647161-3 2004 In the normal adenosine triphosphate cycle, myosin.adenosine diphosphate.phosphate (M.ADP.Pi) binds to actin and moves it by ca. Adenosine Diphosphate 86-89 myosin heavy chain 14 Homo sapiens 44-50 15647162-7 2004 The evidence presented here will argue that a strain-sensitive mechanism of ADP release is universal for all myosins but the basic mechanism has evolved in different ways for different types of myosin. Adenosine Diphosphate 76-79 myosin heavy chain 14 Homo sapiens 109-115 15647167-6 2004 These data are all consistent with the order of events suggested before: myosin.ADP.Pi binds weakly, then strongly to actin, generating force. Adenosine Diphosphate 80-83 myosin heavy chain 14 Homo sapiens 73-79 15585580-4 2004 Here, we show that purified human UAP56 is an active RNA-dependent ATPase, and we also report the crystal structures of UAP56 alone and in complex with ADP, as well as a DECD to DEAD mutant. Adenosine Diphosphate 152-155 DExD-box helicase 39B Homo sapiens 34-39 15585580-4 2004 Here, we show that purified human UAP56 is an active RNA-dependent ATPase, and we also report the crystal structures of UAP56 alone and in complex with ADP, as well as a DECD to DEAD mutant. Adenosine Diphosphate 152-155 DExD-box helicase 39B Homo sapiens 120-125 15319286-4 2004 Intravascular nucleotides released by inflammatory cells undergo phosphohydrolysis via hypoxia-induced CD39 ectoapyrase (CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5"-nucleotidase (CD73 converts AMP to adenosine). Adenosine Diphosphate 185-188 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 103-107 15319286-4 2004 Intravascular nucleotides released by inflammatory cells undergo phosphohydrolysis via hypoxia-induced CD39 ectoapyrase (CD39 converts adenosine triphosphate/adenosine diphosphate [ATP/ADP] to adenosine monophosphate [AMP]) and CD73 ecto-5"-nucleotidase (CD73 converts AMP to adenosine). Adenosine Diphosphate 185-188 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 121-125 15585881-4 2004 ADP (0.05-50 muM) induced calcium flux that was completely blocked by a P2Y1 receptor-selective antagonist and was not cross-desensitized by ATP. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 72-85 15585881-7 2004 Unexpectedly, both ADP and ATP inhibited the generation of TNF-alpha in response to the TLR2 ligand, peptidoglycan, and blocked the production of TNF-alpha, IL-8, and MIP-1beta in response to leukotriene D(4). Adenosine Diphosphate 19-22 C-C motif chemokine ligand 4 Homo sapiens 167-176 15312046-4 2004 AMPKalpha or its kinase-less mutants bind to PPARalpha; binding is increased by MgATP, to a lesser extent by MgADP, but not at all by AMP or ZMP [AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) monophosphate]. Adenosine Diphosphate 109-114 peroxisome proliferator activated receptor alpha Rattus norvegicus 45-54 15533447-7 2004 The thermodynamic linkage between client protein binding and nucleotide affinity revealed ATP bound Hsp90 has a higher affinity for client proteins than the ADP bound form. Adenosine Diphosphate 157-160 heat shock protein 90 alpha family class A member 1 Homo sapiens 100-105 15476670-8 2004 A similar order of potency was observed for the three antagonists in binding to the recombinant human P2Y(1) receptor and in inhibition of ADP-induced shape change and ADP-induced rise in intracellular Ca(2+). Adenosine Diphosphate 139-142 purinergic receptor P2Y1 Homo sapiens 102-117 15476670-8 2004 A similar order of potency was observed for the three antagonists in binding to the recombinant human P2Y(1) receptor and in inhibition of ADP-induced shape change and ADP-induced rise in intracellular Ca(2+). Adenosine Diphosphate 168-171 purinergic receptor P2Y1 Homo sapiens 102-117 15466449-5 2004 ADP-evoked responses were abolished in neurons from P2Y1 receptor-deficient mice (responses to UTP were unaffected). Adenosine Diphosphate 0-3 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 52-65 15465278-3 2004 Upon activation PARP-1 uses NAD(+) as a substrate to catalyze the transfer of ADP-ribose subunits to a host of nuclear proteins. Adenosine Diphosphate 78-81 poly (ADP-ribose) polymerase 1 Rattus norvegicus 16-22 15522416-8 2004 From these results it is proposed that the binding of vanadate oligomers to myosin S1 at the phosphate loop (23 kDa site) is probably the cause of the actin stimulated myosin ATPase inhibition by the prevention of ATP/ADP exchange, and that this interaction is favoured for higher vanadate anions, such as V(10). Adenosine Diphosphate 218-221 myosin heavy chain 14 Homo sapiens 76-82 15522416-8 2004 From these results it is proposed that the binding of vanadate oligomers to myosin S1 at the phosphate loop (23 kDa site) is probably the cause of the actin stimulated myosin ATPase inhibition by the prevention of ATP/ADP exchange, and that this interaction is favoured for higher vanadate anions, such as V(10). Adenosine Diphosphate 218-221 myosin heavy chain 14 Homo sapiens 168-174 15262828-9 2004 In both groups, 600 mg clopidogrel loading significantly inhibited ADP-induced expression of glycoprotein IIb/IIIa and P-selectin receptors. Adenosine Diphosphate 67-70 selectin P Homo sapiens 119-129 15385361-0 2004 Sevoflurane anesthesia attenuates adenosine diphosphate-induced P-selectin expression and platelet-leukocyte conjugate formation. Adenosine Diphosphate 34-55 selectin P Homo sapiens 64-74 15247300-11 2004 Taken together, the results presented here indicate for the first time that mt-hexokinase activity performed a key role as a preventive antioxidant against oxidative stress, reducing mitochondrial ROS generation through an ADP-recycling mechanism. Adenosine Diphosphate 223-226 hexokinase Saccharomyces cerevisiae S288C 79-89 15187029-1 2004 Adenosine diphosphate (ADP), an important platelet agonist, acts through 2 G-protein-coupled receptors (GPCRs), P2Y(1) and P2Y(12), which signal through Gq and Gi, respectively. Adenosine Diphosphate 0-21 purinergic receptor P2Y1 Homo sapiens 112-118 15187029-1 2004 Adenosine diphosphate (ADP), an important platelet agonist, acts through 2 G-protein-coupled receptors (GPCRs), P2Y(1) and P2Y(12), which signal through Gq and Gi, respectively. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 112-118 15247293-7 2004 These results indicate that the ATPase pathway for monomeric Eg5 is more similar to conventional kinesin than the spindle motors Ncd and Kar3, where ADP product release is rate-limiting for steady-state turnover. Adenosine Diphosphate 149-152 kinesin family member 11 Homo sapiens 61-64 15571037-6 2004 This reduction of ADP-ribosylation in old animals is the result of the lower activity of PARP, not of mono(ADP-ribosyl) transferase (MART). Adenosine Diphosphate 18-21 poly (ADP-ribose) polymerase 1 Rattus norvegicus 89-93 15358228-5 2004 The augmentation of glucose-stimulated insulin secretion by adiponectin was accompanied by increased glucose oxidation (P < 0.005), but without any significant effect on palmitate oxidation or the islet ATP/ADP ratio. Adenosine Diphosphate 210-213 adiponectin, C1Q and collagen domain containing Mus musculus 60-71 15296636-7 2004 GM, PU24FCl, ADP, and ATP, all known to bind to the Hsp90 pocket, compete with GM-BODIPY for binding to Hsp90alpha with EC(50)s in agreement with reported values. Adenosine Diphosphate 13-16 heat shock protein 90 alpha family class A member 1 Homo sapiens 104-114 15282455-6 2004 Flow cytometry was used to quantify the spontaneous and induced (adenosine diphosphate stimulation) expression of glycoproteins alphaIIbbeta3, Ibalpha, and CD62P on platelet membranes. Adenosine Diphosphate 65-86 selectin P Homo sapiens 156-161 15286375-3 2004 We report crystal structures of monomeric kinesin KIF1A with three transition-state analogs: adenylyl imidodiphosphate (AMP-PNP), adenosine diphosphate (ADP)-vanadate, and ADP-AlFx (aluminofluoride complexes). Adenosine Diphosphate 130-151 kinesin family member 1A Homo sapiens 50-55 15286375-3 2004 We report crystal structures of monomeric kinesin KIF1A with three transition-state analogs: adenylyl imidodiphosphate (AMP-PNP), adenosine diphosphate (ADP)-vanadate, and ADP-AlFx (aluminofluoride complexes). Adenosine Diphosphate 153-156 kinesin family member 1A Homo sapiens 50-55 15105434-2 2004 The MSH2.MSH6 heterodimer binds 1 mol of ADP and 1 mol of adenosine 5"-O-(thiotriphosphate) (ATPgammaS), with a K(d) for each nucleotide of about 1 microm. Adenosine Diphosphate 41-44 mutS homolog 6 Homo sapiens 9-13 15240477-7 2004 These results suggest that the interplay between the reattached active myosin heads and the thin filament is responsible for the prolonged active contraction in the presence of ADP. Adenosine Diphosphate 177-180 myosin heavy chain 14 Homo sapiens 71-77 15269240-0 2004 Interaction of myosin.ADP.fluorometal complexes with fluorescent probes and direct observation using quick-freeze deep-etch electron microscopy. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 15-21 15269240-1 2004 Myosin forms stable ternary complexes with ADP and phosphate analogues of fluorometals that mimic different ATPase reaction intermediates corresponding to each step of the cross-bridge cycle. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 0-6 15269240-2 2004 In the present study, we monitored the formation of ternary complexes of myosin.ADP.fluorometal using the fluorescence probe prodan. Adenosine Diphosphate 80-83 myosin heavy chain 14 Homo sapiens 73-79 15269240-4 2004 Prodan bound to skeletal muscle heavy-mero-myosin (HMM).ADP.fluorometal, with each complex showing different fluorescence spectra. Adenosine Diphosphate 56-59 myosin heavy chain 14 Homo sapiens 43-49 15158726-5 2004 The alterations in caldesmon orientation were proportional to the strength of S1 binding and diminished respectively upon addition of ADP and ADP-V(i). Adenosine Diphosphate 134-137 caldesmon Oryctolagus cuniculus 19-28 15158726-5 2004 The alterations in caldesmon orientation were proportional to the strength of S1 binding and diminished respectively upon addition of ADP and ADP-V(i). Adenosine Diphosphate 142-145 caldesmon Oryctolagus cuniculus 19-28 15215641-3 2004 The P2Y(1)-receptor agonists 2-methylthio ATP (2meS-ATP) and ADP decreased cell size and increased [Ca(2+)](i) in HUVEC. Adenosine Diphosphate 61-64 purinergic receptor P2Y1 Homo sapiens 4-19 15140134-4 2004 ADP-induced P-selectin expression was inhibited both by MRS 2179 (a P2Y1 selective antagonist) and AR-C69931MX (a P2Y12 selective antagonist), suggesting a role for both Galpha(q) and Galpha(i) pathways in ADP-mediated alpha granule release. Adenosine Diphosphate 0-3 selectin P Homo sapiens 12-22 15140134-4 2004 ADP-induced P-selectin expression was inhibited both by MRS 2179 (a P2Y1 selective antagonist) and AR-C69931MX (a P2Y12 selective antagonist), suggesting a role for both Galpha(q) and Galpha(i) pathways in ADP-mediated alpha granule release. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 68-72 14756556-3 2004 Diphtheria toxin catalyzes the ADP ribosylation of the diphthamide residue of eukaryotic elongation factor 2 (eEF-2). Adenosine Diphosphate 31-34 eukaryotic translation elongation factor 2 Homo sapiens 110-115 14756556-4 2004 The transition state of ADP ribosylation catalyzed by diphtheria toxin has been characterized by measuring a family of kinetic isotope effects using (3)H-, (14)C-, and (15)N-labeled NAD(+) with purified yeast eEF-2. Adenosine Diphosphate 24-27 eukaryotic translation elongation factor 2 Homo sapiens 209-214 14645230-6 2004 These inhibitory actions of Syn-1A can be reversed by physiologic concentrations of ADP and by diazoxide. Adenosine Diphosphate 84-87 syntaxin 1A Rattus norvegicus 28-34 14645230-7 2004 Syn-1A therefore acts to fine-tune the regulation of KATP channels during dynamic changes in cytosolic ATP and ADP concentrations. Adenosine Diphosphate 111-114 syntaxin 1A Rattus norvegicus 0-6 14736431-5 2004 RESULTS: After platelet activation with adenosine diphosphate, thrombin receptor-activating peptide, or U46-619, relative reductions in conformationally activated GP IIb/IIIa receptor expression (evaluated with PAC-1) of 48%, 43%, and 33%, respectively (all p < 0.0001), were seen with clopidogrel, but further 80%, 78%, and 72% (all p < 0.0001) reductions were seen with eptifibatide. Adenosine Diphosphate 40-61 ADCYAP receptor type I Homo sapiens 211-216 15711885-6 2004 The enzymatic activity of myosin was measured by dissociation of fluorescent ADP from the active site. Adenosine Diphosphate 77-80 myosin heavy chain 14 Homo sapiens 26-32 14752238-2 2004 As an isoform of plasma hemopexin (Hx) with protease activity may be implicated in this disease, we have studied the inhibition of Hx by ADP and reactivation to its active form by endothelial or mesangial cells in vitro. Adenosine Diphosphate 137-140 amylase alpha 2B Homo sapiens 35-37 14752238-2 2004 As an isoform of plasma hemopexin (Hx) with protease activity may be implicated in this disease, we have studied the inhibition of Hx by ADP and reactivation to its active form by endothelial or mesangial cells in vitro. Adenosine Diphosphate 137-140 amylase alpha 2B Homo sapiens 131-133 14534308-2 2003 Virtually all platelets stimulated with 10 microM ADP bound strongly to osteopontin, producing rupture forces as great as 100 piconewtons (pN) with a peak at 45-50 pN. Adenosine Diphosphate 50-53 secreted phosphoprotein 1 Homo sapiens 72-83 14534308-7 2003 These experiments demonstrate that ADP stimulation increases the strength of the interaction between platelet alpha v beta 3 and osteopontin. Adenosine Diphosphate 35-38 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 110-124 14534308-7 2003 These experiments demonstrate that ADP stimulation increases the strength of the interaction between platelet alpha v beta 3 and osteopontin. Adenosine Diphosphate 35-38 secreted phosphoprotein 1 Homo sapiens 129-140 12856162-6 2003 p27 overexpression led to a significant increase in the intracellular pool of AMP (8.5-fold), ADP (6-fold) and, more uncommonly, ATP (4.5-fold). Adenosine Diphosphate 94-97 interferon alpha inducible protein 27 Homo sapiens 0-3 14580199-6 2003 Here we report the structure of human RFK cocrystallized with both MgADP and FMN. Adenosine Diphosphate 67-72 riboflavin kinase Homo sapiens 38-41 14504133-3 2003 TRA-418 inhibited platelet GPIIb/IIIa activation as well as P-selectin expression induced by adenosine 5"-diphosphate, thrombin receptor agonist peptide 1-6 (Ser-Phe-Leu-Leu-Arg-Asn-NH2), and U-46619 in the presence of epinephrine (U-46619+ epinephrine). Adenosine Diphosphate 93-117 selectin P Homo sapiens 60-70 12777383-1 2003 Adenine nucleotide translocase-2 (ANT2) catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth. Adenosine Diphosphate 74-77 solute carrier family 25 member 6 Homo sapiens 0-32 12777383-1 2003 Adenine nucleotide translocase-2 (ANT2) catalyzes the exchange of ATP for ADP across the mitochondrial membrane, thus playing an important role in maintaining the cytosolic phosphorylation potential required for cell growth. Adenosine Diphosphate 74-77 solute carrier family 25 member 6 Homo sapiens 34-38 12871123-6 2003 Oxidative stress activates the MPTP by glutathione-mediated cross-linking of Cys(159) and Cys(256) on matrix-facing loops of the ANT that inhibits ADP binding and enhances CyP-D binding. Adenosine Diphosphate 147-150 solute carrier family 25 member 6 Homo sapiens 129-132 12824290-1 2003 We hypothesize that poly (ADP-ribosyl)ation, that is, poly (ADP-ribose) polymerase (PARP)-dependent transfer of ADP-ribose moieties from NAD to nuclear proteins, plays a role in diabetic nephropathy. Adenosine Diphosphate 26-29 poly (ADP-ribose) polymerase 1 Rattus norvegicus 54-82 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 64-69 N-acetylglucosamine kinase Homo sapiens 44-48 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 123-128 N-acetylglucosamine kinase Homo sapiens 44-48 12875848-2 2003 We determine here the crystal structures of NAGK complexes with MgADP, NAG and the transition-state analog AlF(4)(-); with MgADP and NAG; and with ADP and SO(4)(2-). Adenosine Diphosphate 66-69 N-acetylglucosamine kinase Homo sapiens 44-48 12897160-6 2003 In further studies, we have shown that DNA ligase III also binds directly to poly(ADP-ribose) and preferentially associates with poly(ADP-ribosyl)ated PARP-1 in vitro and in vivo. Adenosine Diphosphate 82-85 DNA ligase 3 Homo sapiens 39-53 12791710-4 2003 Therefore, the effect of CP on the actomyosin crossbridge cycle is proposed to occur through a functional link between ADP release from myosin and its rephosphorylation by CP-creatine kinase to regenerate ATP. Adenosine Diphosphate 119-122 myosin heavy chain 14 Homo sapiens 39-45 12654915-5 2003 Based on binding experiments with peptides and polypeptides we propose here a novel mechanism for the targeting action of DnaJ: ATP.DnaK and DnaJ with its substrate-binding domain bind to different segments of one and the same polypeptide chain forming (ATP.DnaK)m.substrate.DnaJn complexes; in these ternary complexes efficient cis-interaction of the J-domain of DnaJ with DnaK is favored by their propinquity and triggers the hydrolysis of DnaK-bound ATP, converting DnaK to its ADP-liganded high affinity state and thus locking it onto the substrate polypeptide. Adenosine Diphosphate 481-484 DnaJ Escherichia coli 141-145 12654915-5 2003 Based on binding experiments with peptides and polypeptides we propose here a novel mechanism for the targeting action of DnaJ: ATP.DnaK and DnaJ with its substrate-binding domain bind to different segments of one and the same polypeptide chain forming (ATP.DnaK)m.substrate.DnaJn complexes; in these ternary complexes efficient cis-interaction of the J-domain of DnaJ with DnaK is favored by their propinquity and triggers the hydrolysis of DnaK-bound ATP, converting DnaK to its ADP-liganded high affinity state and thus locking it onto the substrate polypeptide. Adenosine Diphosphate 481-484 DnaJ Escherichia coli 141-145 12729897-8 2003 These results provide evidence for a PLC gamma 2-independent collagen activation pathway requiring cooperation between GPVI and alpha(2)beta(1) leading to alpha(IIb)beta(3)-dependent aggregation and shape change by released ADP and thromboxane A(2). Adenosine Diphosphate 224-227 phospholipase C, gamma 2 Mus musculus 37-48 12765698-4 2003 Thus, stimulation of TRPM2 is likely to occur after activation of CD38 (producing ADP-ribose) and during the oxidative burst (enhancing the NAD concentration). Adenosine Diphosphate 82-85 CD38 molecule Homo sapiens 66-70 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 215-236 translocase of inner mitochondrial membrane 44 Homo sapiens 262-267 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 238-241 translocase of inner mitochondrial membrane 44 Homo sapiens 178-183 12677068-3 2003 Here, regulated interactions were found to maximize occupancy of the active, adenosine 5"-triphosphate (ATP)-bound mtHsp70 at the channel through its intrinsic high affinity for Tim44, as well as through release of adenosine diphosphate (ADP)-bound mtHsp70 from Tim44 by the cofactor Mge1. Adenosine Diphosphate 238-241 translocase of inner mitochondrial membrane 44 Homo sapiens 262-267 14529392-2 2003 Coactivation of the Galphaq-coupled P2Y1 and Galphai2-coupled P2Y12 receptors is necessary for ADP-mediated platelet activation, which forms the basis of using P2 antagonists as antithrombotic drugs. Adenosine Diphosphate 95-98 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 36-40 14529392-2 2003 Coactivation of the Galphaq-coupled P2Y1 and Galphai2-coupled P2Y12 receptors is necessary for ADP-mediated platelet activation, which forms the basis of using P2 antagonists as antithrombotic drugs. Adenosine Diphosphate 95-98 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 62-67 14644082-4 2003 Complete inhibition of P2Y(12) or P2Y(1) abolished the ADP response, but only inhibition of P2Y(12) reduced the thrombin-induced response. Adenosine Diphosphate 55-58 purinergic receptor P2Y1 Homo sapiens 34-40 14678815-7 2003 In vitro stimulation with ADP, thrombin, or PAF increased platelet P-selectin expression and thus PLA formation, but these responses were not affected by aspirin. Adenosine Diphosphate 26-29 selectin P Homo sapiens 67-77 12913400-0 2002 Lack of alpha 2-antiplasmin enhances ADP induced platelet micro-aggregation through the presence of excess active plasmin in mice. Adenosine Diphosphate 37-40 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 8-27 12913400-6 2002 However, platelet micro-aggregate formation in alpha2-AP(-/-) mice induced by low dose of ADP (1.0 microM) markedly increased compared to the situation in wild type mice. Adenosine Diphosphate 90-93 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 47-56 12324468-6 2002 This conformational state of hsp90 is correlated with the tight binding of ADP resulting from hydrolysis of bound ATP. Adenosine Diphosphate 75-78 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-34 12123418-3 2002 In soleus muscle, the absence of eNOS induced a marked decrease in both basal mitochondrial respiration without ADP (-32%; P <0.05) and maximal respiration in the presence of ADP (-29%; P <0.05). Adenosine Diphosphate 112-115 nitric oxide synthase 3, endothelial cell Mus musculus 33-37 12123418-3 2002 In soleus muscle, the absence of eNOS induced a marked decrease in both basal mitochondrial respiration without ADP (-32%; P <0.05) and maximal respiration in the presence of ADP (-29%; P <0.05). Adenosine Diphosphate 178-181 nitric oxide synthase 3, endothelial cell Mus musculus 33-37 12403632-1 2002 It has been suggested that the mechanical condition determines the rate-limiting step of the ATPase of the myosin heads in fibers: when fibers are isometrically contracting, the ADP release kinetics are rate-limiting, but as the strain is reduced and the fibers are allowed to shorten, the ADP release kinetics accelerate and P(i) release becomes rate-limiting. Adenosine Diphosphate 178-181 myosin heavy chain 14 Homo sapiens 107-113 12403632-1 2002 It has been suggested that the mechanical condition determines the rate-limiting step of the ATPase of the myosin heads in fibers: when fibers are isometrically contracting, the ADP release kinetics are rate-limiting, but as the strain is reduced and the fibers are allowed to shorten, the ADP release kinetics accelerate and P(i) release becomes rate-limiting. Adenosine Diphosphate 290-293 myosin heavy chain 14 Homo sapiens 107-113 16120307-4 2002 Heterozygous mutations of the genes encoding the muscle-heart isoform of the adenosine diphosphate/adenosine triphosphate mitochondrial translocator (ANT1), the main subunit of polymerase gamma (POLG1), and of the putative mtDNA helicase (Twinkle) have been found in adPEO families linked to three different loci, on chromosomes 4q34-35, 10q24, and 15q25, respectively. Adenosine Diphosphate 77-98 solute carrier family 25 member 4 Homo sapiens 150-154 12423666-7 2002 P2Y(1) receptor-selective adenine nucleotides, including 2-MeSADP and ADP, also induced concentration-dependent phosphorylation and hence, activation of the extracellular-signal regulated protein kinases (ERK1/2). Adenosine Diphosphate 62-65 purinergic receptor P2Y1 Homo sapiens 0-15 12239162-6 2002 We found that the antagonism of P2X(1) with ADP or desensitization of this ion channel with alpha,beta-methylene ATP both resulted in impaired ERK2 phosphorylation, ATP secretion, and platelet aggregation induced by low concentrations of collagen (< or = 1 microg/mL) without affecting the minor early dense granule release. Adenosine Diphosphate 44-47 purinergic receptor P2X 1 Homo sapiens 32-38 12383338-7 2002 APCs are characterized by a better preservation of ADP and collagen-induced platelet aggregation, and shorter closure times of the PFA 100 test system during storage. Adenosine Diphosphate 51-54 amyloid P component, serum Homo sapiens 0-4 12198249-10 2002 Our results indicate that PKA-mediated phosphorylation of S1448 in the SUR1 subunit leads to K(ATP) channel closure via an ADP-dependent mechanism. Adenosine Diphosphate 123-126 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 26-29 12198249-11 2002 The marked alteration of the PKA-mediated effects at different ADP levels may provide a cellular mechanism for the glucose-sensitivity of GLP-1. Adenosine Diphosphate 63-66 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 29-32 12140186-1 2002 Adenine nucleotide translocase (Ant) is primarily involved in ATP/ADP exchange across the mitochondrial inner membrane. Adenosine Diphosphate 66-69 solute carrier family 25 member 6 Homo sapiens 0-30 12140186-1 2002 Adenine nucleotide translocase (Ant) is primarily involved in ATP/ADP exchange across the mitochondrial inner membrane. Adenosine Diphosphate 66-69 solute carrier family 25 member 6 Homo sapiens 32-35 12052876-5 2002 We found that Fes1p associates preferentially to the ADP-bound form of the cytosolic Hsp70 molecular chaperone Ssa1p and promotes nucleotide release. Adenosine Diphosphate 53-56 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 111-116 11970953-5 2002 We also show that platelets from mice lacking G(alpha)(i2), which couples to the ADP receptor, P2Y12, exhibit reduced Rap1 activation in response to ADP. Adenosine Diphosphate 81-84 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 95-100 11970953-7 2002 This result, combined with studies of human platelets treated with ADP receptor-selective inhibitors, indicates that ADP-stimulated Rap1 activation in human platelets is dependent on both the G(alpha)(i)-coupled P2Y12 receptor and the G(alpha)(q)-coupled P2Y1 receptor. Adenosine Diphosphate 67-70 RAP1A, member of RAS oncogene family Homo sapiens 132-136 11916974-4 2002 We now show that Cdc37p/p50(cdc37), like Sti1/Hop/p60, also suppresses ATP turnover by Hsp90 supporting the idea that client protein loading to Hsp90 requires a "relaxed" ADP-bound conformation. Adenosine Diphosphate 171-174 stress induced phosphoprotein 1 Homo sapiens 41-45 12022886-8 2002 For the wild type GDH, photolabel-containing peptide generated by tryptic digestion was identified in the region containing the sequence EMSWIADTYASTIG, and the photolabeling of this peptide was prevented >95% by the presence of 1 mM ADP during photolysis, whereas no such a peptide was detected for the Tyr187 mutant GDH in the presence or absence of ADP. Adenosine Diphosphate 355-358 glutamate dehydrogenase 1 Homo sapiens 18-21 12022886-9 2002 These results with cassette mutagenesis and photoaffinity labeling demonstrate selectivity of the photoprobe for the ADP binding site and suggest that the photolabeled peptide is within the ADP binding domain of the human GDH and that Tyr187 is responsible for the efficient base binding of ADP to human GDH. Adenosine Diphosphate 117-120 glutamate dehydrogenase 1 Homo sapiens 222-225 12022886-9 2002 These results with cassette mutagenesis and photoaffinity labeling demonstrate selectivity of the photoprobe for the ADP binding site and suggest that the photolabeled peptide is within the ADP binding domain of the human GDH and that Tyr187 is responsible for the efficient base binding of ADP to human GDH. Adenosine Diphosphate 117-120 glutamate dehydrogenase 1 Homo sapiens 304-307 12022886-9 2002 These results with cassette mutagenesis and photoaffinity labeling demonstrate selectivity of the photoprobe for the ADP binding site and suggest that the photolabeled peptide is within the ADP binding domain of the human GDH and that Tyr187 is responsible for the efficient base binding of ADP to human GDH. Adenosine Diphosphate 190-193 glutamate dehydrogenase 1 Homo sapiens 222-225 12022886-9 2002 These results with cassette mutagenesis and photoaffinity labeling demonstrate selectivity of the photoprobe for the ADP binding site and suggest that the photolabeled peptide is within the ADP binding domain of the human GDH and that Tyr187 is responsible for the efficient base binding of ADP to human GDH. Adenosine Diphosphate 190-193 glutamate dehydrogenase 1 Homo sapiens 222-225 11751935-11 2002 Expression of Dexras1 had no effect on expression of G(i)alpha species, but significantly impaired pertussis toxin-catalyzed ADP-ribosylation of membrane-associated G(i)alpha. Adenosine Diphosphate 125-128 ras related dexamethasone induced 1 Homo sapiens 14-21 11781308-7 2002 Although the modification of Cys(287) but not Cys(326) is required for subunit dissociation, the modification of both Cys(287) and Cys(326) is necessary for the activation of Galpha(i2) as determined by pertussis toxin-catalyzed ADP-ribosylation, conformation-dependent change of trypsin digestion pattern or guanosine 5"-3-O-(thio)triphosphate binding. Adenosine Diphosphate 229-232 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 175-184 11904146-0 2002 ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12). Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 139-145 11827541-0 2002 Transmembrane domains confer different substrate specificities and adenosine diphosphate hydrolysis mechanisms on CD39, CD39L1, and chimeras. Adenosine Diphosphate 67-88 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 114-118 11827541-3 2002 Here we show that the extracellular domain of CD39L1 ecto-adenosine triphosphatase (ecto-ATPase) has the same 3:1 ATP:ADP hydrolysis ratio as the extracellular domain of CD39, suggesting that the transmembrane domains are required to confer the native substrate specificities on each enzyme. Adenosine Diphosphate 118-121 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 46-50 11827541-5 2002 However, H50G substitution diminishes both ATPase and ADPase activities of native CD39L1, in contrast to its selective effect on ATPase activity in CD39, suggesting that the transmembrane domains confer different ADP hydrolysis mechanisms on CD39 and CD39L1. Adenosine Diphosphate 54-57 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 82-86 12806027-3 2002 Both pharmacological and molecular biological approaches have confirmed the role of the P2Y1 and P2Y12 receptors in the ADP-induced platelet fibrinogen receptor activation. Adenosine Diphosphate 120-123 purinergic receptor P2Y1 Homo sapiens 88-92 11790308-6 2002 However, while ADP, ADP-Pi, and newly polymerized ATP-filaments are all capable of supporting Arp2/3-mediated branching, newly polymerized F-actin supports most of the Arp2/3-induced branch formation. Adenosine Diphosphate 15-18 actin related protein 2 Homo sapiens 94-98 11756171-1 2002 Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A(2), another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. Adenosine Diphosphate 0-21 purinergic receptor P2Y1 Homo sapiens 192-196 11756171-1 2002 Adenosine diphosphate (ADP) is a platelet agonist that causes platelet shape change and aggregation as well as generation of thromboxane A(2), another platelet agonist, through its effects on P2Y1, P2Y12, and P2X1 receptors. Adenosine Diphosphate 23-26 purinergic receptor P2Y1 Homo sapiens 192-196 11852667-10 2002 After 8- and 12-weeks of therapy, significant decreases were observed in the following: (1) total blood cholesterol and low density lipoprotein-C (P < 0.01), (2) ADP-induced maximum platelet aggregation (P < 0.01), (3) TXB2 or thromboxane B2 in platelets (P < 0.01), and (4) expression of GMP-140 or granule membrane protein-140 (P < 0.01). Adenosine Diphosphate 165-168 selectin P Homo sapiens 298-305 11852667-10 2002 After 8- and 12-weeks of therapy, significant decreases were observed in the following: (1) total blood cholesterol and low density lipoprotein-C (P < 0.01), (2) ADP-induced maximum platelet aggregation (P < 0.01), (3) TXB2 or thromboxane B2 in platelets (P < 0.01), and (4) expression of GMP-140 or granule membrane protein-140 (P < 0.01). Adenosine Diphosphate 165-168 selectin P Homo sapiens 309-337 11892285-17 2002 While substantial rotational dynamics, both internal and global, exist in both myosin and actin in the presence of ADP or the absence of nucleotides, spin label EPR, pyrene fluorescence, and phosphorescence all show dramatic restrictions in these motions upon formation of the strong ternary complex (right column of Fig. Adenosine Diphosphate 115-118 myosin heavy chain 14 Homo sapiens 79-85 11752435-6 2001 The Arp2/3 complex bound to ADP or the nonhydrolyzable ATP analogue AMP-PNP cannot nucleate actin filaments, but addition of the phosphate analogue BeF(3) partially restores activity to the ADP-Arp2/3 complex. Adenosine Diphosphate 28-31 actin related protein 2 Homo sapiens 4-8 11752435-6 2001 The Arp2/3 complex bound to ADP or the nonhydrolyzable ATP analogue AMP-PNP cannot nucleate actin filaments, but addition of the phosphate analogue BeF(3) partially restores activity to the ADP-Arp2/3 complex. Adenosine Diphosphate 28-31 actin related protein 2 Homo sapiens 194-198 11590173-0 2001 Differing ADP release rates from myosin heavy chain isoforms define the shortening velocity of skeletal muscle fibers. Adenosine Diphosphate 10-13 myosin heavy chain 14 Homo sapiens 33-39 11753636-5 2001 The ANT-dependent membrane permeabilization was inhibited by the two ANT ligands ATP and ADP, as well as by recombinant Bcl-2 protein. Adenosine Diphosphate 89-92 solute carrier family 25 member 6 Homo sapiens 4-7 11763165-2 2001 Only recently was it discovered that they bind with high specificity within the ADP/ATP binding pocket of the Hsp90 molecular chaperone, thereby inhibiting the function of Hsp90. Adenosine Diphosphate 80-83 heat shock protein 90 alpha family class A member 1 Homo sapiens 110-115 11763165-2 2001 Only recently was it discovered that they bind with high specificity within the ADP/ATP binding pocket of the Hsp90 molecular chaperone, thereby inhibiting the function of Hsp90. Adenosine Diphosphate 80-83 heat shock protein 90 alpha family class A member 1 Homo sapiens 172-177 11641440-1 2001 The P2Y(1) receptor is responsible for the initiation of platelet aggregation in response to ADP and plays a key role in thrombosis. Adenosine Diphosphate 93-96 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 4-19 11674863-2 2001 ADP initiates platelet activation via the P2Y(1) receptor and amplifies platelet activation via the P2Y(12) receptor. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 42-57 11674863-8 2001 These studies demonstrate that P2Y(1) receptor activation plays a significant role in amplifying aggregation induced by agonists other than ADP, in addition to the established roles of P2Y(12) receptor activation and thromboxane A(2) synthesis. Adenosine Diphosphate 140-143 purinergic receptor P2Y1 Homo sapiens 31-46 11606309-8 2001 We conclude that thrombin-induced endostatin release from rat platelets is PAR4-mediated via an ADP-independent mechanism that can occur independently of platelet aggregation. Adenosine Diphosphate 96-99 F2R like thrombin or trypsin receptor 3 Rattus norvegicus 75-79 11574484-3 2001 We report here the X-ray crystal structures of the conserved N-terminal 40 kDa fragment of hPMS2, NhPMS2, and its complexes with ATPgammaS and ADP at 1.95, 2.7 and 2.7 A resolution, respectively. Adenosine Diphosphate 143-146 PMS1 homolog 2, mismatch repair system component Homo sapiens 91-96 11606185-9 2001 Activation of phospholipase C by convulxin was potentiated by ADP acting through the P2Y12 receptor. Adenosine Diphosphate 62-65 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 85-90 11729369-7 2001 The percentage of platelets expressing P-selectin in response to 0.2 microM adenosine diphosphate (ADP) was greater in coronary arterial samples from patients with ACS (aorta=6.1+/-1%, coronary artery=8.8+/-1.6%, p=0.02) compared with that in patients with stable symptoms (aorta=6.9+/-1.2, coronary artery=6.5+/-1.4, p=NS). Adenosine Diphosphate 76-97 selectin P Homo sapiens 39-49 11729369-7 2001 The percentage of platelets expressing P-selectin in response to 0.2 microM adenosine diphosphate (ADP) was greater in coronary arterial samples from patients with ACS (aorta=6.1+/-1%, coronary artery=8.8+/-1.6%, p=0.02) compared with that in patients with stable symptoms (aorta=6.9+/-1.2, coronary artery=6.5+/-1.4, p=NS). Adenosine Diphosphate 99-102 selectin P Homo sapiens 39-49 16120279-3 2001 The adenine nucleotide translocator (ANT), the last step in oxidative phosphorylation catalyses the exchange of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) between the cytosol and mitochondria. Adenosine Diphosphate 112-133 solute carrier family 25 member 6 Homo sapiens 4-35 16120279-3 2001 The adenine nucleotide translocator (ANT), the last step in oxidative phosphorylation catalyses the exchange of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) between the cytosol and mitochondria. Adenosine Diphosphate 112-133 solute carrier family 25 member 6 Homo sapiens 37-40 16120279-3 2001 The adenine nucleotide translocator (ANT), the last step in oxidative phosphorylation catalyses the exchange of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) between the cytosol and mitochondria. Adenosine Diphosphate 135-138 solute carrier family 25 member 6 Homo sapiens 4-35 16120279-3 2001 The adenine nucleotide translocator (ANT), the last step in oxidative phosphorylation catalyses the exchange of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) between the cytosol and mitochondria. Adenosine Diphosphate 135-138 solute carrier family 25 member 6 Homo sapiens 37-40 11483668-2 2001 Here we show that cultured hippocampal astrocytes coexpress the ectoenzyme CD38, directly involved in the metabolism of the calcium mobilizer cyclic ADP-ribose, and the NAD+ transporter connexin 43. Adenosine Diphosphate 149-152 CD38 molecule Homo sapiens 75-79 11447076-8 2001 The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P>0.90). Adenosine Diphosphate 205-208 POU class 2 homeobox 3 Homo sapiens 144-152 11418468-0 2001 Novel structurally altered P(2X1) receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells. Adenosine Diphosphate 74-95 purinergic receptor P2X 1 Homo sapiens 27-42 11418649-12 2001 We propose that one of these is cell surface ART2.2 activity (defective in the NZW parent), the other a downstream effector of ADP-ribosylation (defective in the C57BL/6 parent). Adenosine Diphosphate 127-130 ADP-ribosyltransferase 2b Mus musculus 45-51 12561530-5 2001 The coupling of cell respiration with ADP phosphorylation is only partial in brown adipose tissue (BAT) mitochondria, where UCP causes a reentry of protons into the matrix and abolishes the electrochemical proton gradient. Adenosine Diphosphate 38-41 uncoupling protein 1 Homo sapiens 124-127 11287418-10 2001 Similarly, Pgp in the transition state conformation generated with either ADP or ATP exhibits drastically reduced affinity for the binding of analogues of drug substrate ([(125)I]iodoarylazidoprazosin) as well as nucleotide (2"(3")-O-(2,4,6-trinitrophenyl)adenosine 5"-triphosphate). Adenosine Diphosphate 74-77 phosphoglycolate phosphatase Homo sapiens 11-14 11287418-12 2001 In aggregate, these results demonstrate that the Pgp.[alpha-(32)P]8-azido-ADP (or ADP).Vi transition state complexes generated either in the absence of or accompanying [alpha-(32)P]8-azido-ATP hydrolysis are functionally indistinguishable. Adenosine Diphosphate 74-77 phosphoglycolate phosphatase Homo sapiens 49-52 11389023-8 2001 The combination of JAQ1 and adrenaline or ADP, but not serotonin, resulted in alpha(IIb)beta(3)-dependent aggregation that occurred without intracellular calcium mobilization and shape change in the absence of Galphaq or the P2Y(1) receptor. Adenosine Diphosphate 42-45 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 225-240 11411543-4 2001 This chimeric hAAC1 showed similar ADP transport activity to that of chimeric bAAC1, corresponding to the transport activity of bAAC1 in bovine heart mitochondria. Adenosine Diphosphate 35-38 solute carrier family 25 member 4 Homo sapiens 14-19 11350929-2 2001 Here, a 55 kDa protein, glutamate dehydrogenase (GDH), was established as a specific acceptor for enzymatic, cysteine-specific ADP-ribosylation in mitochondria. Adenosine Diphosphate 127-130 glutamate dehydrogenase 1 Homo sapiens 24-47 11350929-2 2001 Here, a 55 kDa protein, glutamate dehydrogenase (GDH), was established as a specific acceptor for enzymatic, cysteine-specific ADP-ribosylation in mitochondria. Adenosine Diphosphate 127-130 glutamate dehydrogenase 1 Homo sapiens 49-52 11743896-6 2001 RESULTS: Insulin 1 U/kg sc daily for 9 weeks improved oxidative phosphorylation, respiratory rate state 3 (P < 0.05), respiratory control ration (P < 0.01), and ADP:O ratio (P < 0.01), but there were no obvious effect on respiratory rate state 4 (P > 0.05). Adenosine Diphosphate 167-170 insulin 1 Rattus norvegicus 9-18 11352081-7 2001 Furthermore, only the RESTORE dosage of tirofiban and abciximab reduced P-selectin expression in response to ADP. Adenosine Diphosphate 109-112 selectin P Homo sapiens 72-82 11341507-2 2001 The P2Y1 receptor was found to be involved in i) the centralization of secretory granules elicited by ADP, ii) the formation of filopodia induced by released ADP in weakly activated platelets and iii) actin polymerization and the cytoskeletal translocation of cdc42, rac1 and rhoA, in an integrin alphaIIbbeta3 dependent manner, in ADP-stimulated platelets. Adenosine Diphosphate 102-105 purinergic receptor P2Y1 Homo sapiens 4-17 11341507-2 2001 The P2Y1 receptor was found to be involved in i) the centralization of secretory granules elicited by ADP, ii) the formation of filopodia induced by released ADP in weakly activated platelets and iii) actin polymerization and the cytoskeletal translocation of cdc42, rac1 and rhoA, in an integrin alphaIIbbeta3 dependent manner, in ADP-stimulated platelets. Adenosine Diphosphate 158-161 purinergic receptor P2Y1 Homo sapiens 4-17 11341507-2 2001 The P2Y1 receptor was found to be involved in i) the centralization of secretory granules elicited by ADP, ii) the formation of filopodia induced by released ADP in weakly activated platelets and iii) actin polymerization and the cytoskeletal translocation of cdc42, rac1 and rhoA, in an integrin alphaIIbbeta3 dependent manner, in ADP-stimulated platelets. Adenosine Diphosphate 158-161 purinergic receptor P2Y1 Homo sapiens 4-17 11302472-6 2001 Adenosine diphosphate- and thrombin-induced platelet P-selectin expression was slightly, but significantly, decreased by the glucose load, whereas platelet P-selectin expression in unstimulated samples was not affected. Adenosine Diphosphate 0-21 selectin P Homo sapiens 53-63 11298606-6 2001 The transient platelet refractoriness and microaggregate formation induced by ADP was associated with a transient reduction in glycoprotein (GP)Ib, increased P-selectin expression and increased fibrinogen binding by circulating platelets. Adenosine Diphosphate 78-81 selectin P Homo sapiens 158-168 11237788-4 2001 MATERIALS AND METHODS: P-selectin expression in non-fixed, whole blood was measured flow cytometrically on non-stimulated and ADP- and TRAP-6-stimulated samples. Adenosine Diphosphate 126-129 selectin P Homo sapiens 23-33 11139608-4 2001 Pct1p also hydrolyzes ATP to ADP and P(i) in the presence of manganese or cobalt (K(m) = 19 microM ATP; k(cat) = 67 s(-1)). Adenosine Diphosphate 29-32 choline-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 0-5 11591225-1 2001 BACKGROUND: The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. Adenosine Diphosphate 38-41 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 45-94 11591225-1 2001 BACKGROUND: The hydrolysis of ATP and ADP by ecto-nucleoside triphosphate diphosphohydrolase 1 (CD39) requires divalent cations, like Ca2+ and Mg2+. Adenosine Diphosphate 38-41 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 96-100 11161246-6 2001 CaCl2 and ADP were used as aggregants for the two TST tests (TST-CaCl2 and TST-ADP), and ADP- or epinephrine (Epi)-coated membranes were used with the two PFA tests (PFA-ADP and PFA-Epi). Adenosine Diphosphate 10-13 thiosulfate sulfurtransferase Homo sapiens 50-53 11161246-6 2001 CaCl2 and ADP were used as aggregants for the two TST tests (TST-CaCl2 and TST-ADP), and ADP- or epinephrine (Epi)-coated membranes were used with the two PFA tests (PFA-ADP and PFA-Epi). Adenosine Diphosphate 10-13 thiosulfate sulfurtransferase Homo sapiens 61-64 11161246-6 2001 CaCl2 and ADP were used as aggregants for the two TST tests (TST-CaCl2 and TST-ADP), and ADP- or epinephrine (Epi)-coated membranes were used with the two PFA tests (PFA-ADP and PFA-Epi). Adenosine Diphosphate 10-13 thiosulfate sulfurtransferase Homo sapiens 61-64 11101898-2 2000 The actomyosin structures determined in the presence and absence of MgADP differ significantly from each other, and from all crystallographic structures of unbound myosin. Adenosine Diphosphate 68-73 myosin heavy chain 14 Homo sapiens 8-14 11101898-3 2000 Coupled to a complex movement ( approximately 34 A) of the light chain binding domain upon MgADP release, we observed a approximately 9 degrees rotation of the myosin motor domain relative to the actin filament, and a closure of the cleft that divides the actin binding region of the myosin head. Adenosine Diphosphate 91-96 myosin heavy chain 14 Homo sapiens 160-166 11101898-3 2000 Coupled to a complex movement ( approximately 34 A) of the light chain binding domain upon MgADP release, we observed a approximately 9 degrees rotation of the myosin motor domain relative to the actin filament, and a closure of the cleft that divides the actin binding region of the myosin head. Adenosine Diphosphate 91-96 myosin heavy chain 14 Homo sapiens 284-290 11139946-8 2000 To determine the effect of heart rate and atrial pressure (RAP), measurements were repeated after 10 minutes of ventricular pacing (120 beats/min) in patients with SR. P-selectin expression was increased in patients with AF at baseline (AF: 1329 +/- 81 BC vs SR: 968 +/- 108 BC; P < 0.05) and after stimulation with ADP (AF: 1445 +/- 101 BC vs SR: 1061 +/- 109 BC; P < 0.05) and TRAP (AF: 13,783 +/- 2442 BC vs SR: 5977 +/- 800 BC; P < 0.05). Adenosine Diphosphate 319-322 selectin P Homo sapiens 168-178 11035085-10 2000 Finally, using a new FACS assay for monitoring ADP-ribosylation of cell surface proteins, we demonstrate that shedding of ART2.2 correlates with a reduced sensitivity of T cell surface proteins to ADP-ribosylation. Adenosine Diphosphate 47-50 ADP-ribosyltransferase 2b Mus musculus 122-128 11035085-10 2000 Finally, using a new FACS assay for monitoring ADP-ribosylation of cell surface proteins, we demonstrate that shedding of ART2.2 correlates with a reduced sensitivity of T cell surface proteins to ADP-ribosylation. Adenosine Diphosphate 197-200 ADP-ribosyltransferase 2b Mus musculus 122-128 10969013-0 2000 ADP inhibition of myosin V ATPase activity. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 18-24 10969013-16 2000 This presents technical problems in analyzing and interpreting the kinetics of myosin V and likely of other members of the myosin family with high ADP affinities. Adenosine Diphosphate 147-150 myosin heavy chain 14 Homo sapiens 79-85 10960076-1 2000 ADP, an important agonist in thrombosis and haemostasis, has been reported to activate platelets via three receptors, P2X(1), P2Y(1) and P2T(AC). Adenosine Diphosphate 0-3 purinergic receptor P2X 1 Homo sapiens 118-124 10960076-1 2000 ADP, an important agonist in thrombosis and haemostasis, has been reported to activate platelets via three receptors, P2X(1), P2Y(1) and P2T(AC). Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 126-132 10960076-2 2000 Given the low potency of ADP at P2X(1) receptors and recognized contamination of commercial samples of adenosine nucleotides, we have re-examined the activation of P2X(1) receptors by ADP following HPLC and enzymatic purification. Adenosine Diphosphate 25-28 purinergic receptor P2X 1 Homo sapiens 32-38 11052891-5 2000 Thus, rearrangements in the acto-myosin interface are likely to occur elsewhere than in the lower 50-kDa subdomain of myosin as its affinity for actin is weakened by MgADP binding. Adenosine Diphosphate 166-171 myosin heavy chain 14 Homo sapiens 33-39 11052891-5 2000 Thus, rearrangements in the acto-myosin interface are likely to occur elsewhere than in the lower 50-kDa subdomain of myosin as its affinity for actin is weakened by MgADP binding. Adenosine Diphosphate 166-171 myosin heavy chain 14 Homo sapiens 118-124 10922052-7 2000 Addition of ATP or ADP accelerates release (t(1/2) approximately 1 min), consistent with a model in which ATP hydrolysis induces a conformation of ClpX with low affinity for unfolded substrates. Adenosine Diphosphate 19-22 caseinolytic mitochondrial matrix peptidase chaperone subunit X Homo sapiens 147-151 11030463-2 2000 In this study we show that the Ca2+ chelator BAPTA and the Rho-kinase inhibitor Y-27632 inhibit ADP-induced myosin light chain (MLC) phosphorylation and platelet shape change through distinct pathways and with distinct kinetics. Adenosine Diphosphate 96-99 megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Mus musculus 108-126 11030463-2 2000 In this study we show that the Ca2+ chelator BAPTA and the Rho-kinase inhibitor Y-27632 inhibit ADP-induced myosin light chain (MLC) phosphorylation and platelet shape change through distinct pathways and with distinct kinetics. Adenosine Diphosphate 96-99 megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) Mus musculus 128-131 11030463-7 2000 We conclude that ADP-induced shape change occurs via the P2Y1 receptor, which can be differentially coupled to Rho-kinase and Ca2+-linked pathways dependent on the method of platelet preparation. Adenosine Diphosphate 17-20 purinergic receptor P2Y, G-protein coupled 1 Mus musculus 57-70 10894791-6 2000 The order of potency for nucleotide analogs was ATP = UTP > adenosine 5"-O-[thiotriphosphate] >> ADP > UDP, which is consistent with the pharmacology of the P2Y2 receptor subtype. Adenosine Diphosphate 106-109 LOC100009486 Oryctolagus cuniculus 169-182 10851205-7 2000 However, at 24 hours, basal P-selectin expression declined in patients (P=0.0025 versus baseline), whereas ADP-stimulated P-selectin expression was lower in patients than in control subjects (48% versus 69%, P=0. Adenosine Diphosphate 107-110 selectin P Homo sapiens 122-132 10827983-0 2000 Comparative single-molecule and ensemble myosin enzymology: sulfoindocyanine ATP and ADP derivatives. Adenosine Diphosphate 85-88 myosin heavy chain 14 Homo sapiens 41-47 10788495-4 2000 This preparation as well as Gbeta(1)gamma(2-His) supported pertussis toxin-mediated ADP-ribosylation of Galpha(i1). Adenosine Diphosphate 84-87 nischarin Homo sapiens 104-113 10759852-0 2000 The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets. Adenosine Diphosphate 27-30 purinergic receptor P2Y1 Homo sapiens 4-17 10725427-7 2000 It is reported that E7 expression leads to regulation of the genes encoding the calcium-binding protein S100P and the mitochondrial ADP/ATP carrier protein. Adenosine Diphosphate 132-135 S100 calcium binding protein P Homo sapiens 104-109 10704646-5 2000 Postoperative P-selectin and glycoprotein Ib expression stimulated with ADP correlated to blood loss. Adenosine Diphosphate 72-75 selectin P Homo sapiens 14-24 10653805-5 2000 Myosin complexed with ADP and the phosphate analog V(i) or AlF(4) binds weakly to actin and is an analog of a pre-power-stroke state. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 0-6 10728364-7 2000 Abciximab increased ADP-induced P-selectin expression. Adenosine Diphosphate 20-23 selectin P Homo sapiens 32-42 10728364-9 2000 Neither agent altered ADP-induced CD63 expression. Adenosine Diphosphate 22-25 CD63 molecule Homo sapiens 34-38 10694233-0 2000 ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 55-61 10515978-15 1999 In summary, these data suggest that the activation of dendritic voltage-gated Ca(2+) channels, by large-amplitude backpropagating spikes, provides a prolonged inward current that is capable of generating an ADP and burst of multiple action potentials in the soma of CA1 pyramidal neurons. Adenosine Diphosphate 207-210 carbonic anhydrase 1 Rattus norvegicus 266-269 10544922-2 1999 We have recently shown that concomitant intracellular signaling from both the P2TAC and P2Y1 receptors is essential for ADP-induced platelet aggregation. Adenosine Diphosphate 120-123 purinergic receptor P2Y1 Homo sapiens 88-92 10486282-6 1999 The TPO synergism on Ca(2+) mobilization and CD62P expression was measurable in different, nonoverlapping ranges of ADP or TRAP concentrations. Adenosine Diphosphate 116-119 selectin P Homo sapiens 45-50 10389773-3 1999 The expression of P-selectin was determined under basal conditions, after the incubation of blood with adenosine diphosphate (ADP) 10 micromol/L, and the stable prostaglandin endoperoxide analog U46619 1 micromol/L. Adenosine Diphosphate 103-124 selectin P Homo sapiens 18-28 10389773-3 1999 The expression of P-selectin was determined under basal conditions, after the incubation of blood with adenosine diphosphate (ADP) 10 micromol/L, and the stable prostaglandin endoperoxide analog U46619 1 micromol/L. Adenosine Diphosphate 126-129 selectin P Homo sapiens 18-28 10364211-3 1999 We have previously shown that an additional effect of BFA is to stimulate the ADP-ribosylation of two cytosolic proteins of 38 and 50 kDa (brefeldin A-ADP-riboslyated substrate (BARS)) and that this effect greatly facilitates the Golgi-disassembling activity of the toxin. Adenosine Diphosphate 78-81 C-terminal binding protein 1 Rattus norvegicus 139-176 10364211-3 1999 We have previously shown that an additional effect of BFA is to stimulate the ADP-ribosylation of two cytosolic proteins of 38 and 50 kDa (brefeldin A-ADP-riboslyated substrate (BARS)) and that this effect greatly facilitates the Golgi-disassembling activity of the toxin. Adenosine Diphosphate 78-81 C-terminal binding protein 1 Rattus norvegicus 178-182 10411652-5 1999 We show here that PtdIns, PtdIns4P, PtdIns3,4P2, PtdIns4,5P2 and PtdInsP3 enhance not only the C3-dependent ADP-ribosylation, but also the GDP/GTP exchange in the RhoA component of the prenylated RhoA/Rho-GDI complex. Adenosine Diphosphate 108-111 Rho GDP dissociation inhibitor alpha Homo sapiens 201-208 10199955-2 1999 Upon DNA damage PARP binds to DNA strand breaks and transfers ADP-ribose residues from NAD+ to acceptor proteins and to ADP-ribosyl protein adducts. Adenosine Diphosphate 62-65 Poly-(ADP-ribose) polymerase Drosophila melanogaster 16-20 10090736-1 1999 The P2Y1 receptor is a G protein-coupled receptor (GPCR) and is stimulated by extracellular ADP and ATP. Adenosine Diphosphate 92-95 purinergic receptor P2Y1 Homo sapiens 4-17 10066429-7 1999 These results provide further evidence that P2Y1 receptors contribute to platelet ADP responses. Adenosine Diphosphate 82-85 purinergic receptor P2Y1 Homo sapiens 44-48 10102474-5 1999 Platelet activation defined by the surface expression of CD62P was not induced by aCL+ x LA+ plasma only, but was significantly augmented by aCL+ x LA+ plasma in combination with adenosine diphosphate (ADP) at a low concentration that had only a modest effect on platelet activation. Adenosine Diphosphate 179-200 selectin P Homo sapiens 57-62 10102474-5 1999 Platelet activation defined by the surface expression of CD62P was not induced by aCL+ x LA+ plasma only, but was significantly augmented by aCL+ x LA+ plasma in combination with adenosine diphosphate (ADP) at a low concentration that had only a modest effect on platelet activation. Adenosine Diphosphate 202-205 selectin P Homo sapiens 57-62 9931016-4 1999 The ecto-apyrase was also expressed in the presence of tunicamycin, which completely prevented N-linked glycosylation, resulting in a nonglycosylated core protein devoid of ATP and ADP hydrolyzing activity. Adenosine Diphosphate 181-184 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 4-16 10872464-5 1999 Kinetics shows that the binding of myosin to actin is a two-step process which affects ATP and ADP affinity. Adenosine Diphosphate 95-98 myosin heavy chain 14 Homo sapiens 35-41 9914505-1 1999 Mouse T-cell antigens Rt6.1 and Rt6.2 are glycosylphosphatidylinositol-anchored arginine-specific adenosine diphosphate (ADP)-ribosyltransferases. Adenosine Diphosphate 121-124 ADP-ribosyltransferase 2b Mus musculus 32-37 10348701-5 1999 By contrast, the P2Y1 receptor antagonist adenosine 3",5"-diphosphate (A3P5P) inhibited ADP-induced platelet aggregation, completely abolished shape change, but did not antagonize ADP effects on cyclic AMP generation or [3H]2-methylthio-ADP binding. Adenosine Diphosphate 88-91 purinergic receptor P2Y1 Homo sapiens 17-30 9857010-6 1998 Most mutant PMA2 H+-ATPases were characterized by a higher specific activity, lower inhibition by ADP, and lower stimulation by lysophosphatidylcholine than wild-type PMA2. Adenosine Diphosphate 98-101 H(+)-exporting P2-type ATPase PMA2 Saccharomyces cerevisiae S288C 12-16 9852909-9 1998 Relaxations of precontracted coronary arterioles to VEGF were significantly increased (40 +/- 6% at 10(-12) mol/L, P < 0.05 vs pre-CPB) after 2 hours of reperfusion, but those to the endothelium-dependent vasodilator ADP and the endothelium-independent vasodilator nitroprusside were not changed, suggesting that the VEGF receptors remain intact and function is selectively upregulated. Adenosine Diphosphate 220-223 vascular endothelial growth factor A Sus scrofa 52-56 9788896-5 1998 The role of protein phosphatases in termination of the ADP-stimulated respiratory burst of AM was examined with calyculin A (CA) (25-75 nM) or okadaic acid (OA) (1-5 microM), two inhibitors of protein phosphatase 1 and 2a (PP1;PP2a). Adenosine Diphosphate 55-58 protein phosphatase 2 phosphatase activator Homo sapiens 227-231 9783263-3 1998 Proteolytic cleavage and disulfide bridge reduction in the DTA-DTB linker region of DTx are required for optimal ADP-ribosylation of elongation factor 2 (EF-2). Adenosine Diphosphate 113-116 eukaryotic translation elongation factor 2 Homo sapiens 133-152 9783263-3 1998 Proteolytic cleavage and disulfide bridge reduction in the DTA-DTB linker region of DTx are required for optimal ADP-ribosylation of elongation factor 2 (EF-2). Adenosine Diphosphate 113-116 eukaryotic translation elongation factor 2 Homo sapiens 154-158 9736628-4 1998 We found that both MuB-ADP and MuB-ATP stimulate transposase, whereas only MuB-ATP binds with high affinity to DNA. Adenosine Diphosphate 23-26 ubiquitin like 3 Homo sapiens 19-22 9736628-7 1998 Based on these studies, we propose that the switch from the ATP- to ADP-bound form allows MuB to release the target DNA while maintaining its stimulatory interaction with transposase. Adenosine Diphosphate 68-71 ubiquitin like 3 Homo sapiens 90-93 9748490-8 1998 (2) In contrast, ADP, as MgADP, increased the Km value for MgATP of PRS I as well as the Ka value for free Mg2+. Adenosine Diphosphate 17-20 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 68-73 9748490-8 1998 (2) In contrast, ADP, as MgADP, increased the Km value for MgATP of PRS I as well as the Ka value for free Mg2+. Adenosine Diphosphate 25-30 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 68-73 9748490-9 1998 (3) High concentrations of free Mg2+ almost completely nullified the inhibitory effect of MgGDP and partly that of MgADP on PRS I. Adenosine Diphosphate 115-120 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 124-129 9692980-4 1998 The affinity for both actins is 5-8-fold lower with ADP bound to actin rather than ATP. Adenosine Diphosphate 52-55 actin Oryctolagus cuniculus 22-27 9692980-7 1998 As a result, profilin binding reduces the affinity of actin 3-fold for Mg-ATP and 24-fold for Mg-ADP. Adenosine Diphosphate 94-100 actin Oryctolagus cuniculus 54-59 9692980-9 1998 Mg-ADP dissociates 14 times faster from actin-profilin than from actin and binds actin-profilin half as fast as actin. Adenosine Diphosphate 0-6 actin Oryctolagus cuniculus 40-45 9692980-9 1998 Mg-ADP dissociates 14 times faster from actin-profilin than from actin and binds actin-profilin half as fast as actin. Adenosine Diphosphate 0-6 actin Oryctolagus cuniculus 65-70 9692980-9 1998 Mg-ADP dissociates 14 times faster from actin-profilin than from actin and binds actin-profilin half as fast as actin. Adenosine Diphosphate 0-6 actin Oryctolagus cuniculus 65-70 9692980-9 1998 Mg-ADP dissociates 14 times faster from actin-profilin than from actin and binds actin-profilin half as fast as actin. Adenosine Diphosphate 0-6 actin Oryctolagus cuniculus 65-70 9692990-0 1998 Raman difference spectroscopic studies of the myosin S1.MgADP.vanadate complex. Adenosine Diphosphate 56-61 myosin heavy chain 14 Homo sapiens 46-52 9692990-8 1998 Assuming that the distortions that vanadate undergoes upon forming the S1.MgADP.Vi complex are analogous to the changes of the gamma-phosphate of ATP in the transition state of the myosin-catalyzed hydrolysis, our results suggest that this reaction proceeds close to a concerted (SN2-like) process. Adenosine Diphosphate 74-79 myosin heavy chain 14 Homo sapiens 181-187 9651346-3 1998 More significantly, this RNA-binding protein is able to degrade RNAs with the resultant production of nucleotide diphosphates, and it can add extended polyadenylate tracts to RNAs using ADP as a donor for adenylate moieties. Adenosine Diphosphate 186-189 RNA binding motif single stranded interacting protein 3 Homo sapiens 25-44 9624189-6 1998 ARL1 stimulation of CT-catalyzed ADP-ribosylation was considerably less than that by rARF1 and was phospholipid dependent. Adenosine Diphosphate 33-36 ADP ribosylation factor like GTPase 1 Homo sapiens 0-4 9606181-3 1998 The nucleotide-free or ADP-bound form of Vps4p existed as a dimer, whereas in the ATP-locked state, Vps4p dimers assembled into a decameric complex. Adenosine Diphosphate 23-26 AAA family ATPase VPS4 Saccharomyces cerevisiae S288C 41-46 9614197-4 1998 The trinitrophenyl analogs of ATP, ADP, AMP, and GTP produced a reversible inhibition of ATP-evoked currents in human embryonic kidney 293 cells expressing P2X1 receptors, P2X3 receptors, or both P2X2 and P2X3 (heteromeric) receptors; IC50 values were close to 1 nM. Adenosine Diphosphate 35-38 purinergic receptor P2X 1 Homo sapiens 156-160 9614197-4 1998 The trinitrophenyl analogs of ATP, ADP, AMP, and GTP produced a reversible inhibition of ATP-evoked currents in human embryonic kidney 293 cells expressing P2X1 receptors, P2X3 receptors, or both P2X2 and P2X3 (heteromeric) receptors; IC50 values were close to 1 nM. Adenosine Diphosphate 35-38 purinergic receptor P2X 2 Homo sapiens 196-200 9675904-4 1998 The deduced amino acid sequence of Ss1 shares 75.7% sequence identity with rice soluble Ss and contains the highly conserved KSGGLGDV putative ADP-Glc binding site. Adenosine Diphosphate 143-146 starch synthase I, chloroplastic Zea mays 35-38 9547364-12 1998 In conclusion, the rat and human P2Y1 receptors are ADP-specific receptors that recognize ADP and 2-methylthio-ADP, whereas ATP, 2-MeSATP, and 2-ClATP are competitive antagonists. Adenosine Diphosphate 52-55 purinergic receptor P2Y1 Homo sapiens 33-37 9545001-14 1998 IGF-I and IGF-BP3 increment on dP (and sustained on adP) is possibly due to liver regeneration, in contrast with inhibition of body growth on dP, possibly due to central and peripheral effects of corticosteroid. Adenosine Diphosphate 52-55 insulin like growth factor binding protein 3 Homo sapiens 10-17 9442040-2 1998 The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. Adenosine Diphosphate 27-30 purinergic receptor P2Y1 Homo sapiens 4-17 9442040-10 1998 ADP or 2-methyl(thio)-ADP-induced intracellular calcium increases were inhibited by the P2Y1 receptor-specific antagonists, adenosine 3"-phosphate 5"-phosphosulfate (A3P5PS), adenosine 3"-phosphate 5"-phosphate (A3P5P), and adenosine 2"-phosphate 5"-phosphate (A2P5P), in a concentration-dependent manner, but not by ARL 66096 or alpha, beta-MeATP. Adenosine Diphosphate 0-3 purinergic receptor P2Y1 Homo sapiens 88-101 9889814-7 1998 Since ATP reacts rapidly with the myosin head (M) to form the complex (M.ADP.Pi) having average lifetime of > 10 s, the observed myosin head movement may be mostly associated with reaction, M + ATP-->M.ADP.Pi. Adenosine Diphosphate 73-76 myosin heavy chain 14 Homo sapiens 34-40 9889814-7 1998 Since ATP reacts rapidly with the myosin head (M) to form the complex (M.ADP.Pi) having average lifetime of > 10 s, the observed myosin head movement may be mostly associated with reaction, M + ATP-->M.ADP.Pi. Adenosine Diphosphate 208-211 myosin heavy chain 14 Homo sapiens 34-40 9889817-10 1998 Using these methods the following measurements can be made: rate of ATP induced dissociation of actomyosin, the affinity of ADP for actomyosin, the rate of ADP release from actomyosin and the affinity of actin for myosin and myosin ADP. Adenosine Diphosphate 124-127 myosin heavy chain 14 Homo sapiens 136-142 9449337-3 1998 This result can be explained in terms of cross-bridge models in which the release of Pi is involved in the transition from a weakly bound, low-force actin x myosin x ADP x Pi state to a strongly bound, high-force, actin x myosin x ADP state. Adenosine Diphosphate 166-169 unconventional myosin-X Oryctolagus cuniculus 157-165 9449337-3 1998 This result can be explained in terms of cross-bridge models in which the release of Pi is involved in the transition from a weakly bound, low-force actin x myosin x ADP x Pi state to a strongly bound, high-force, actin x myosin x ADP state. Adenosine Diphosphate 166-169 unconventional myosin-X Oryctolagus cuniculus 222-230 9449337-3 1998 This result can be explained in terms of cross-bridge models in which the release of Pi is involved in the transition from a weakly bound, low-force actin x myosin x ADP x Pi state to a strongly bound, high-force, actin x myosin x ADP state. Adenosine Diphosphate 231-234 unconventional myosin-X Oryctolagus cuniculus 157-165 9449337-3 1998 This result can be explained in terms of cross-bridge models in which the release of Pi is involved in the transition from a weakly bound, low-force actin x myosin x ADP x Pi state to a strongly bound, high-force, actin x myosin x ADP state. Adenosine Diphosphate 231-234 unconventional myosin-X Oryctolagus cuniculus 222-230 9422605-2 1998 strain ADP metabolizes atrazine to cyanuric acid via three plasmid-encoded enzymes, AtzA, AtzB, and AtzC. Adenosine Diphosphate 7-10 AtzC Pseudomonas sp. ADP 100-104 9386152-3 1997 Platelet activation in response to adenosine diphosphate (ADP) or collagen was detected by assay of P-selectin on the platelet surface delineated by flow cytometry. Adenosine Diphosphate 35-56 selectin P Homo sapiens 100-110 9386152-3 1997 Platelet activation in response to adenosine diphosphate (ADP) or collagen was detected by assay of P-selectin on the platelet surface delineated by flow cytometry. Adenosine Diphosphate 58-61 selectin P Homo sapiens 100-110 9386152-4 1997 Although minimal activation was seen without ADP, the fraction of platelets expressing P-selectin in response to ADP was greatest in blood anticoagulated with citrate compared with CTI and all other anticoagulants. Adenosine Diphosphate 113-116 selectin P Homo sapiens 87-97 9515109-7 1997 Release of EDRF by the cell membrane may be mediated by G proteins sensitive to pertussis toxin (activation of the alpha 2 adrenoreceptor, serotonin, platelet aggregation, leukotrienes) or non-sensitive G proteins (adenosine-diphosphate (ADP), bradykinin). Adenosine Diphosphate 215-236 alpha hemoglobin stabilizing protein Homo sapiens 11-15 9515109-7 1997 Release of EDRF by the cell membrane may be mediated by G proteins sensitive to pertussis toxin (activation of the alpha 2 adrenoreceptor, serotonin, platelet aggregation, leukotrienes) or non-sensitive G proteins (adenosine-diphosphate (ADP), bradykinin). Adenosine Diphosphate 238-241 alpha hemoglobin stabilizing protein Homo sapiens 11-15 9364994-4 1997 This latter effect was linked to a diminished P-selectin expression on ADP-stimulated whole blood platelets in normal pregnant women (p = 0.011). Adenosine Diphosphate 71-74 selectin P Homo sapiens 46-56 9109504-6 1997 However, in the absence of ADP, the nerve tissue-specific GDH showed only 5% of its maximal activity, compared with approximately 40% showed by the housekeeping enzyme. Adenosine Diphosphate 27-30 glutamate dehydrogenase 1 Homo sapiens 58-61 9109504-7 1997 Low physiological levels of ADP (0.05-0.25 mM) induced a concentration-dependent enhancement of enzyme activity that was proportionally greater for the nerve tissue GDH (by 550-1,300%) than of the housekeeping enzyme (by 120-150%). Adenosine Diphosphate 28-31 glutamate dehydrogenase 1 Homo sapiens 165-168 9109504-8 1997 Magnesium chloride (1-2 mM) inhibited the nonactivated housekeeping GDH (by 45-64%); this inhibition was reversed almost completely by ADP. Adenosine Diphosphate 135-138 glutamate dehydrogenase 1 Homo sapiens 68-71 9100014-1 1997 Threonine 244 in the alpha subunit of Paracoccus denitrificans transfer flavoprotein (ETF) lies seven residues to the amino terminus of a proposed dinucleotide binding motif for the ADP moiety of the FAD prosthetic group. Adenosine Diphosphate 182-185 TEA domain transcription factor 2 Homo sapiens 86-89 9047298-1 1997 The ionic strength dependence of skeletal muscle myosin subfragment 1 (S1) binding to actin in the presence of ADP and ATP was measured for S1 with either only an essential light chain [S1(elc)] or with both an essential and the regulatory light chains [S1(elc,rlc)] bound. Adenosine Diphosphate 111-114 myosin heavy chain 14 Homo sapiens 49-55 8994427-6 1997 In addition, fibrinogen binding and P-selectin expression were measured in response to ex vivo stimulation with the agonists ADP and thrombin. Adenosine Diphosphate 125-128 selectin P Homo sapiens 36-46 8995221-2 1997 In these circumstances, GroES could only partially discharge the DHFR if ADP was present in the solution and approximately half of the DHFR remained bound on the chaperonin. Adenosine Diphosphate 73-76 dihydrofolate reductase Homo sapiens 65-69 9105634-2 1997 Vascular ATP-diphosphohydrolase (ATPDase) has been demonstrated on both aortic EC and smooth muscle cells and may play a key regulatory role in hemostasis and platelet reactivity by converting extracellular ATP and ADP to AMP. Adenosine Diphosphate 215-218 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 9-31 9105634-2 1997 Vascular ATP-diphosphohydrolase (ATPDase) has been demonstrated on both aortic EC and smooth muscle cells and may play a key regulatory role in hemostasis and platelet reactivity by converting extracellular ATP and ADP to AMP. Adenosine Diphosphate 215-218 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 33-40 8988019-6 1996 The transport inhibitors (GTP, GDP, ATP, and ADP) also inhibit this channel in a reversible way, showing that the channel activity is associated with UCP. Adenosine Diphosphate 45-48 uncoupling protein 1 Homo sapiens 150-153 8955160-1 1996 Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Adenosine Diphosphate 114-117 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 9-31 8955160-1 1996 Vascular ATP diphosphohydrolase (ATPDase) is a plasma membrane-bound enzyme that hydrolyses extracellular ATP and ADP to AMP. Adenosine Diphosphate 114-117 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 33-40 8955160-5 1996 We also demonstrated that ATPDase could inhibit platelet aggregation in response to ADP, collagen, and thrombin, and that this activity in transfected COS-7 cells was lost following exposure to oxidative stress. Adenosine Diphosphate 84-87 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 26-33 9010772-5 1996 [32P]ADP-ribosylation of p33 occurred in the extracellular space, induced by the stimulus of A23187 or opsonized zymosan in the presence of [32P]NAD. Adenosine Diphosphate 5-8 leukocyte cell derived chemotaxin 2 Gallus gallus 25-28 9131414-8 1996 ADP also causes a rapid calcium influx which has the characteristics of a receptor-operated channel, and it has been suggested that this is due to a P2X1 receptor. Adenosine Diphosphate 0-3 purinergic receptor P2X 1 Homo sapiens 149-162 8994083-5 1996 In the presence of constant concentrations of MgATP, increasing the MgADP concentrations from 0.5 to 2mM, decreased the bi-directional sliding velocity of actin. Adenosine Diphosphate 68-73 actin Oryctolagus cuniculus 155-160 8874211-2 1996 Invasion is blocked by pertussis toxin (PT), which adenosine diphosphate (ADP)-ribosylates G1-proteins, and we have provided evidence that the PT-sensitive signal stimulates leukocyte function-associated antigen-1 (LFA-1)-mediated adhesion required for invasion. Adenosine Diphosphate 51-72 integrin alpha L Mus musculus 174-213 8874211-2 1996 Invasion is blocked by pertussis toxin (PT), which adenosine diphosphate (ADP)-ribosylates G1-proteins, and we have provided evidence that the PT-sensitive signal stimulates leukocyte function-associated antigen-1 (LFA-1)-mediated adhesion required for invasion. Adenosine Diphosphate 51-72 integrin alpha L Mus musculus 215-220 8874211-2 1996 Invasion is blocked by pertussis toxin (PT), which adenosine diphosphate (ADP)-ribosylates G1-proteins, and we have provided evidence that the PT-sensitive signal stimulates leukocyte function-associated antigen-1 (LFA-1)-mediated adhesion required for invasion. Adenosine Diphosphate 74-77 integrin alpha L Mus musculus 174-213 8874211-2 1996 Invasion is blocked by pertussis toxin (PT), which adenosine diphosphate (ADP)-ribosylates G1-proteins, and we have provided evidence that the PT-sensitive signal stimulates leukocyte function-associated antigen-1 (LFA-1)-mediated adhesion required for invasion. Adenosine Diphosphate 74-77 integrin alpha L Mus musculus 215-220 8900395-0 1996 Characterization of ADP-ribosylation sites on desmin and restoration of desmin intermediate filament assembly by de-ADP-ribosylation . Adenosine Diphosphate 20-23 desmin Homo sapiens 46-52 8900395-0 1996 Characterization of ADP-ribosylation sites on desmin and restoration of desmin intermediate filament assembly by de-ADP-ribosylation . Adenosine Diphosphate 20-23 desmin Homo sapiens 72-78 8900395-0 1996 Characterization of ADP-ribosylation sites on desmin and restoration of desmin intermediate filament assembly by de-ADP-ribosylation . Adenosine Diphosphate 116-119 desmin Homo sapiens 72-78 8900395-10 1996 Arginines 48 and 68 of desmin"s head domain were shown to be sites of modification, with arginine 48 the major ADP-ribosylation site. Adenosine Diphosphate 111-114 desmin Homo sapiens 23-29 8900395-12 1996 Removal of more than three ADP-ribose groups results in partial restoration of desmin"s ability to form intermediate filaments. Adenosine Diphosphate 27-30 desmin Homo sapiens 79-85 8900395-13 1996 It is necessary to remove all ADP-ribose groups from desmin to restore its complete ability to form intermediate filaments. Adenosine Diphosphate 30-33 desmin Homo sapiens 53-59 8784354-0 1996 ADP release produces a rotation of the neck region of smooth myosin but not skeletal myosin. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 61-67 8784354-3 1996 The angle of the probes on smooth myosin S1 were changed by 20 degrees +/- 4 degrees on addition of ADP (50% effect at 5 +/- 2 microM), but ADP produced little effect on skeletal S1. Adenosine Diphosphate 100-103 myosin heavy chain 14 Homo sapiens 34-40 8702942-6 1996 Ssa1p adopted three distinct conformations, nucleotide-free, ADP-dependent, and ATP-dependent. Adenosine Diphosphate 61-64 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 0-5 8781562-7 1996 Phosphorylation and dephosphorylation of immunoprecipitates with AS/7 by protein kinase A (PKA) and alkaline phosphatase caused decreases and increases in IAP-catalyzed ADP-ribosylation, respectively, indicating the presence of PKA-mediated phosphorylation sites on Gi2 alpha. Adenosine Diphosphate 169-172 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 91-94 8781562-7 1996 Phosphorylation and dephosphorylation of immunoprecipitates with AS/7 by protein kinase A (PKA) and alkaline phosphatase caused decreases and increases in IAP-catalyzed ADP-ribosylation, respectively, indicating the presence of PKA-mediated phosphorylation sites on Gi2 alpha. Adenosine Diphosphate 169-172 magnesium transporter 1 Rattus norvegicus 155-158 8672542-6 1996 The stimulated Ca2+ efflux is inhibited by ADP or atractyloside suggesting that the Ca2+ transport mechanism might be intrinsic to the ADP/ATP carrier (AAC). Adenosine Diphosphate 43-46 WD and tetratricopeptide repeats 1 Homo sapiens 135-150 8762814-1 1996 We previously identified a receptor for granulocyte colony-stimulating factor (G-CSFR) on platelet membranes, and reported that G-CSF enhanced ADP-induced platelet aggregation. Adenosine Diphosphate 143-146 colony stimulating factor 3 Homo sapiens 40-77 8762814-1 1996 We previously identified a receptor for granulocyte colony-stimulating factor (G-CSFR) on platelet membranes, and reported that G-CSF enhanced ADP-induced platelet aggregation. Adenosine Diphosphate 143-146 colony stimulating factor 3 Homo sapiens 79-85 8762814-1 1996 We previously identified a receptor for granulocyte colony-stimulating factor (G-CSFR) on platelet membranes, and reported that G-CSF enhanced ADP-induced platelet aggregation. Adenosine Diphosphate 143-146 colony stimulating factor 3 Homo sapiens 79-84 8633060-5 1996 The purified enzyme transfers a phosphate from PP-IP5 to ADP to form ATP. Adenosine Diphosphate 57-60 peptidylprolyl isomerase A pseudogene 15 Homo sapiens 47-53 8630037-3 1996 This indicated that with ATP the complex of myosin with the product, M.ADP.Pi, at the long lived intermediate state of the rate limiting step would play a key role for efficient mechanochemical energy transduction during actin-myosin interaction. Adenosine Diphosphate 71-74 myosin heavy chain 14 Homo sapiens 44-50 8630037-3 1996 This indicated that with ATP the complex of myosin with the product, M.ADP.Pi, at the long lived intermediate state of the rate limiting step would play a key role for efficient mechanochemical energy transduction during actin-myosin interaction. Adenosine Diphosphate 71-74 myosin heavy chain 14 Homo sapiens 227-233 8606780-4 1996 Here we report the crystal structure of the MgADP complex of the Drosophila ncd motor domain determined to 2.5A by X-ray crystallography, and compare it to the kinesin structure. Adenosine Diphosphate 44-49 Kinesin light chain Drosophila melanogaster 160-167 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 105-126 ADCYAP receptor type I Homo sapiens 16-20 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 128-131 ADCYAP receptor type I Homo sapiens 16-20 8599944-6 1996 DnaJ, through rapid association with sigma32 and stimulation of hydrolysis of DnaK-bound ATP, mediates efficient binding of DnaK to sigma32 in the presence of ATP, resulting in DnaK-DnaJ-sigma32 complexes containing ADP. Adenosine Diphosphate 216-219 DnaJ Escherichia coli 0-4 8599944-6 1996 DnaJ, through rapid association with sigma32 and stimulation of hydrolysis of DnaK-bound ATP, mediates efficient binding of DnaK to sigma32 in the presence of ATP, resulting in DnaK-DnaJ-sigma32 complexes containing ADP. Adenosine Diphosphate 216-219 DnaJ Escherichia coli 182-186 8564538-1 1996 Extensive three-dimensional structural resemblances between biotin carboxylase and the ADP-forming peptide synthetases, represented by glutathione synthetase and D-Ala:D-Ala ligase, reveal a previously unsuspected evolutionary relationship between two major families of ADP-forming ligases. Adenosine Diphosphate 87-90 glutathione synthetase Homo sapiens 135-157 8573568-2 1996 Specifically, the catalytic (C) domain of DT transfers the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. Adenosine Diphosphate 59-62 eukaryotic translation elongation factor 2 Homo sapiens 86-105 8573568-2 1996 Specifically, the catalytic (C) domain of DT transfers the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. Adenosine Diphosphate 59-62 eukaryotic translation elongation factor 2 Homo sapiens 107-111 8573568-3 1996 In order to investigate how the C-domain of DT binds NAD and catalyzes the ADP-ribosylation of EF-2, the crystal structure of DT in complex with NAD has been determined to 2.3 A resolution. Adenosine Diphosphate 75-78 eukaryotic translation elongation factor 2 Homo sapiens 95-99 8573568-6 1996 Residues 39-46 of the active-site loop of the C-domain become disordered upon NAD binding, suggesting a potential role for this loop in the recognition of the ADP-ribose acceptor substrate, EF-2. Adenosine Diphosphate 159-162 eukaryotic translation elongation factor 2 Homo sapiens 190-194 8750931-3 1996 Choleratoxin catalysed the ADP ribosylation of 45 kDa and 52 kDa membrane proteins and islet activating protein (IAP) catalysed the ADP ribosylation of a 40 kDa membrane protein. Adenosine Diphosphate 132-135 magnesium transporter 1 Rattus norvegicus 87-111 8750931-3 1996 Choleratoxin catalysed the ADP ribosylation of 45 kDa and 52 kDa membrane proteins and islet activating protein (IAP) catalysed the ADP ribosylation of a 40 kDa membrane protein. Adenosine Diphosphate 132-135 magnesium transporter 1 Rattus norvegicus 113-116 8713797-7 1996 PSG3 inhibited platelet aggregation induced by either ADP or collagen, it also inhibited fibrinogen binding to activated platelets in a dose-dependent fashion. Adenosine Diphosphate 54-57 pregnancy specific beta-1-glycoprotein 3 Homo sapiens 0-4 7573423-9 1995 In contrast, the primary regulatory factors causing greater PDHa during recovery were lower ATP/ADP and NADH/NAD and increased concentrations of pyruvate and H+. Adenosine Diphosphate 96-99 pyruvate dehydrogenase E1 subunit alpha 1 Homo sapiens 60-64 8569728-6 1995 The results also demonstrate that, in contrast to PKC phosphorylation, ADP-ribosylation of B-50 does not mediate CaM binding. Adenosine Diphosphate 71-74 growth associated protein 43 Homo sapiens 91-95 7624370-5 1995 Moreover, ADP-ribosylation of BARS-50 was completely inhibited by the beta gamma subunit complex of G proteins, while the ADP-ribosylation of GAPDH was unmodified, indicating that this effect was due to an interaction of the beta gamma complex with BARS-50, rather than with the ADP-ribosylating enzyme. Adenosine Diphosphate 10-13 C-terminal binding protein 1 Rattus norvegicus 30-37 7624370-5 1995 Moreover, ADP-ribosylation of BARS-50 was completely inhibited by the beta gamma subunit complex of G proteins, while the ADP-ribosylation of GAPDH was unmodified, indicating that this effect was due to an interaction of the beta gamma complex with BARS-50, rather than with the ADP-ribosylating enzyme. Adenosine Diphosphate 10-13 C-terminal binding protein 1 Rattus norvegicus 249-256 7608558-2 1995 We show here that the soluble extracellular domain of CD38 (sCD38) mediates ADP ribosylation of several proteins. Adenosine Diphosphate 76-79 CD38 molecule Homo sapiens 54-58 7602094-4 1995 We found that partial ADP-ribosylation of the Gi2/Gi3 proteins before stimulation with IL-1 was sufficient to obtain full inhibition of IL-2 release. Adenosine Diphosphate 22-25 interleukin 2 Mus musculus 136-140 7737974-13 1995 The enhanced ATP dissociation caused by both polypeptide substrates and Ydj1p may play a role in the regulation of Ssa1p chaperone activity by altering the relative abundance of ATP-and ADP-bound forms. Adenosine Diphosphate 186-189 Hsp70 family ATPase SSA1 Saccharomyces cerevisiae S288C 115-120 7721841-2 1995 Since ADP-ribosylarginine hydrolase, the enzyme responsible for cleavage of the ADP-ribosylarginine bond and a component with the transferase of a putative ADP-ribosylation cycle, is cytosolic, the processing of ADP-ribosylated integrin alpha 7 was investigated. Adenosine Diphosphate 6-9 integrin alpha 7 Mus musculus 228-244 7787248-3 1995 This fraction of actin could be prevented from polymerization by being ADP bound (therefore less favored to polymerize) or by being ATP bound and sequestered by a protein such as thymosin beta 4, or both. Adenosine Diphosphate 71-74 actin like 6A S homeolog Xenopus laevis 17-22 7740516-1 1995 Treatment of Fura-2 loaded HEL cells, a human megakaryocyte-like cell line, with P2-purinoceptor nucleotide ligands (ADP, ATP, UTP, 2-methylthio-ATP) evoked a rise in cytosolic calcium. Adenosine Diphosphate 117-120 pyrimidinergic receptor P2Y6 Homo sapiens 81-96 8863900-4 1995 In the presence of MgADP, flexibility changes in the multisubunit structure of myosins were detected, but this did not lead to changes of the overall rotational property of the myosin heads. Adenosine Diphosphate 19-24 myosin heavy chain 14 Homo sapiens 79-85 7711244-2 1995 Both of these ligands bind to an actin.myosin.ADP state that follows the release of Pi in the enzymatic cycle, and their effects on muscle fibers and proteins in solution provide information on the properties of this state. Adenosine Diphosphate 46-49 myosin heavy chain 14 Homo sapiens 39-45 7711247-1 1995 Inorganic phosphate (Pi) decreases the isometric tension of skinned skeletal muscle fibers, presumably by increasing the relative fraction of a low force quaternary complex of actin, myosin, ADP, and Pi (A.M.ADP.Pi). Adenosine Diphosphate 208-211 actin Oryctolagus cuniculus 176-181 8904203-1 1995 The platelet receptor for ADP has been classified as a P2 purinoceptor of the P2T type where ADP is the natural agonist and ATP a competitive antagonist. Adenosine Diphosphate 26-29 pyrimidinergic receptor P2Y6 Homo sapiens 55-70 7725803-7 1994 Mcm2, a protein important for ARS activity, as well as Aac2, one of the three isoforms of the mitochondrial ATP/ADP carrier, were previously described (Yan et al., 1991; Lawson and Douglas, 1988). Adenosine Diphosphate 112-115 MCM DNA helicase complex subunit MCM2 Saccharomyces cerevisiae S288C 0-4 7937953-4 1994 The binding and release of substrate protein for folding involves the following ATP hydrolysis-dependent cycle: (i) unfolded luciferase binds initially to DnaJ; (ii) upon interaction with luciferase-DnaJ, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable luciferase-DnaK-DnaJ complex; (iii) GrpE releases ADP from DnaK; and (iv) ATP binding to DnaK triggers the release of substrate protein, thus completing the reaction cycle. Adenosine Diphosphate 325-328 DnaJ Escherichia coli 199-203 7937953-4 1994 The binding and release of substrate protein for folding involves the following ATP hydrolysis-dependent cycle: (i) unfolded luciferase binds initially to DnaJ; (ii) upon interaction with luciferase-DnaJ, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable luciferase-DnaK-DnaJ complex; (iii) GrpE releases ADP from DnaK; and (iv) ATP binding to DnaK triggers the release of substrate protein, thus completing the reaction cycle. Adenosine Diphosphate 325-328 DnaJ Escherichia coli 199-203 7863463-2 1994 DMP 728 demonstrated a potent antiplatelet efficacy in inhibiting ADP-induced platelet aggregation in either human or canine PRP with an IC50 of 0.046 and 0.015 microM, respectively. Adenosine Diphosphate 66-69 mastin Canis lupus familiaris 0-3 8086484-1 1994 We examined the roles of myosin light-chain kinase in platelet responses to ADP using wortmannin, which almost completely inhibited myosin light-chain kinase at 3-6 microM. Adenosine Diphosphate 76-79 myosin light chain kinase Homo sapiens 25-50 8086484-1 1994 We examined the roles of myosin light-chain kinase in platelet responses to ADP using wortmannin, which almost completely inhibited myosin light-chain kinase at 3-6 microM. Adenosine Diphosphate 76-79 myosin light chain kinase Homo sapiens 132-157 8086484-5 1994 Wortmannin at concentrations which prevented myosin light-chain kinase also inhibited platelet aggregation induced by ADP in the presence of U46619, an analogue of thromboxane A2, which is a prerequisite for ADP-induced irreversible aggregation. Adenosine Diphosphate 118-121 myosin light chain kinase Homo sapiens 45-70 8086484-5 1994 Wortmannin at concentrations which prevented myosin light-chain kinase also inhibited platelet aggregation induced by ADP in the presence of U46619, an analogue of thromboxane A2, which is a prerequisite for ADP-induced irreversible aggregation. Adenosine Diphosphate 208-211 myosin light chain kinase Homo sapiens 45-70 8086484-7 1994 These results suggest that myosin light-chain kinase activation is a prerequisite for ADP-induced platelet aggregation, but not for changes in their shape. Adenosine Diphosphate 86-89 myosin light chain kinase Homo sapiens 27-52 7605610-1 1994 In an ADP-ribosylation reaction, we have observed the radiolabelling of a protein in a crude bovine brain homogenate, which upon two-dimensional gel electrophoresis migrated with an acidic pI (< 4.5) and an apparent molecular mass (80-90 kDa) consistent with the properties of the myristoylated, alanine-rich, protein kinase C substrate protein termed MARCKS. Adenosine Diphosphate 6-9 myristoylated alanine rich protein kinase C substrate Bos taurus 355-361 7605610-3 1994 Concordant increases in radiolabelling and silver staining of the same protein component from the MARCKS-supplemented ADP-ribosylation reaction, as compared with the ADP-ribosylated crude homogenate, established the identity of this constituent as MARCKS. Adenosine Diphosphate 118-121 myristoylated alanine rich protein kinase C substrate Bos taurus 98-104 7605610-3 1994 Concordant increases in radiolabelling and silver staining of the same protein component from the MARCKS-supplemented ADP-ribosylation reaction, as compared with the ADP-ribosylated crude homogenate, established the identity of this constituent as MARCKS. Adenosine Diphosphate 118-121 myristoylated alanine rich protein kinase C substrate Bos taurus 248-254 7605610-4 1994 The radiolabelling of MARCKS was lower in comparison with the ADP-ribosylation of the related neuronal protein B-50/GAP-43 under identical reaction conditions. Adenosine Diphosphate 62-65 growth associated protein 43 Bos taurus 116-122 7605610-5 1994 The potential functional consequences of the ADP-ribosylation of MARCKS are discussed and the possibility is raised that other members of the MARCKS family, such as the F52/MacMARCKS/MRP protein, may also be subject to ADP-ribosylation. Adenosine Diphosphate 45-48 myristoylated alanine rich protein kinase C substrate Bos taurus 65-71 7605610-5 1994 The potential functional consequences of the ADP-ribosylation of MARCKS are discussed and the possibility is raised that other members of the MARCKS family, such as the F52/MacMARCKS/MRP protein, may also be subject to ADP-ribosylation. Adenosine Diphosphate 45-48 myristoylated alanine rich protein kinase C substrate Bos taurus 142-148 8053684-4 1994 Both ADP analogs are competitive inhibitors for the binding of ADP to the phosphoenzyme with KADPS = 0.45 mM: alpha,beta-CH2-ADP and ADP beta S bind to the phosphoenzyme with K alpha,beta-CH2-ADPS = 0.92 mM and KADP beta SS = 0.05 mM, respectively. Adenosine Diphosphate 5-8 WD and tetratricopeptide repeats 1 Homo sapiens 110-128 8053684-4 1994 Both ADP analogs are competitive inhibitors for the binding of ADP to the phosphoenzyme with KADPS = 0.45 mM: alpha,beta-CH2-ADP and ADP beta S bind to the phosphoenzyme with K alpha,beta-CH2-ADPS = 0.92 mM and KADP beta SS = 0.05 mM, respectively. Adenosine Diphosphate 63-66 WD and tetratricopeptide repeats 1 Homo sapiens 110-128 8053684-6 1994 The rate acceleration of > 10(5) for phosphoryl transfer from Ca2.E approximately P.Mg to ADP compared to alpha,beta-CH2-ADP can be attributed to the differences in both the structure and the net charge of ADP compared with alpha,beta-CH2-ADP at pH 7.0. Adenosine Diphosphate 93-96 WD and tetratricopeptide repeats 1 Homo sapiens 109-127 8053684-6 1994 The rate acceleration of > 10(5) for phosphoryl transfer from Ca2.E approximately P.Mg to ADP compared to alpha,beta-CH2-ADP can be attributed to the differences in both the structure and the net charge of ADP compared with alpha,beta-CH2-ADP at pH 7.0. Adenosine Diphosphate 93-96 WD and tetratricopeptide repeats 1 Homo sapiens 227-245 8053684-6 1994 The rate acceleration of > 10(5) for phosphoryl transfer from Ca2.E approximately P.Mg to ADP compared to alpha,beta-CH2-ADP can be attributed to the differences in both the structure and the net charge of ADP compared with alpha,beta-CH2-ADP at pH 7.0. Adenosine Diphosphate 124-127 WD and tetratricopeptide repeats 1 Homo sapiens 227-245 7919168-2 1994 Post hoc sodium nitroprusside-induced ADP ribosylation of some proteins (particularly a p43 and a p39 protein) in homogenates from stimulated hippocampus was reduced at preconvulsive stage II and stage V (tonic-clonic seizures) of dentate gyrus kindling compared with controls. Adenosine Diphosphate 38-41 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Homo sapiens 88-91 8075337-7 1994 A similar analysis of the spectra of fibers with ADP bound to myosin revealed a small (approximately 5 degrees-10 degrees) torsional reorientation, without a substantial change of the tilt angle (< 2 degrees). Adenosine Diphosphate 49-52 myosin heavy chain 14 Homo sapiens 62-68 7519037-1 1994 Whole blood flow cytometry has revealed that platelets undergo partial degranulation in response to ADP, in the absence of aggregation, as evidenced by the expression of the P-selectin and CD63 antigens of the alpha-granule and lysosomal membranes respectively. Adenosine Diphosphate 100-103 selectin P Homo sapiens 174-184 7519037-4 1994 beta-thromboglobulin release from the ADP-stimulated platelets correlated closely with the expression of P-selectin and CD63 (r = 0.98 +/- 0.02 for both antigens). Adenosine Diphosphate 38-41 selectin P Homo sapiens 105-115 7519037-4 1994 beta-thromboglobulin release from the ADP-stimulated platelets correlated closely with the expression of P-selectin and CD63 (r = 0.98 +/- 0.02 for both antigens). Adenosine Diphosphate 38-41 CD63 molecule Homo sapiens 120-124 8311468-7 1994 Auto-ADP-ribosylated transferase showed higher activity than did the unmodified transferase in catalyzing ADP-ribosylation of the basic acceptor such as poly(L-arginine) and p33 while to ADP-ribosylate the acidic proteins such as casein, the modified transferase was less active. Adenosine Diphosphate 5-8 leukocyte cell derived chemotaxin 2 Gallus gallus 174-177 8288949-4 1994 On the other hand, we show that ADP and Zn2+ exert a cooperative effect on the phosphorylation of P-47 protein (pleckstrin), a substrate of protein kinase C in platelets. Adenosine Diphosphate 32-35 pleckstrin Homo sapiens 112-122 8152339-3 1994 In control subjects, maximum platelet aggregation and PAI-1 secretion were observed within 5 min in response to the different agonists including thrombin, collagen, adenosine diphosphate (ADP), and arachidonic acid. Adenosine Diphosphate 165-186 serpin family E member 1 Homo sapiens 54-59 8118422-4 1993 In contrast, the cultured with low glucose concentrations induced the increases of both islet activating protein (IAP)-catalyzed ADP-ribosylation of Gi alpha and Na+/glucose cotransport activity. Adenosine Diphosphate 129-132 CD47 molecule Sus scrofa 88-112 8118422-4 1993 In contrast, the cultured with low glucose concentrations induced the increases of both islet activating protein (IAP)-catalyzed ADP-ribosylation of Gi alpha and Na+/glucose cotransport activity. Adenosine Diphosphate 129-132 CD47 molecule Sus scrofa 114-117 8292722-3 1993 Turbidometrically measured platelet aggregation response to ADP was shown to be a linear function (r = 0.9) of the logarithm of residual free binding sites for c7E3-Fab. Adenosine Diphosphate 60-63 FA complementation group B Homo sapiens 165-168 7691596-1 1993 The uncoupling protein (UCP) of brown adipose tissue mitochondria is a specialized member of the family of evolutionarily related mitochondrial membrane transporters, which also includes the ADP/ATP translocator and the phosphate carrier. Adenosine Diphosphate 191-194 uncoupling protein 1 Homo sapiens 24-27 8399168-5 1993 Complex formation is demonstrated between ADF and actin containing either ATP, ADP, or AMPPNP as the bound nucleotide. Adenosine Diphosphate 79-82 actin, beta Gallus gallus 50-55 8396441-3 1993 Participation of myosin-ATPase in binding of ADP within cells as it was supposed earlier (Saks, V.A., Belikova, Yu.O. Adenosine Diphosphate 45-48 myosin heavy chain 14 Homo sapiens 17-23 8223953-0 1993 Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils. Adenosine Diphosphate 37-40 gelsolin Homo sapiens 0-8 8392374-9 1993 The pertussis toxin-catalyzed ADP-ribosylation on alpha-subunit was enhanced by either beta gamma-subunit subspecies, but the effect was larger with beta gamma-I than with beta gamma-II. Adenosine Diphosphate 30-33 G protein subunit gamma 7 Bos taurus 177-185 7689939-6 1993 Two antibodies to human P-selectin KC4.1 and AC1.2 crossreacted with canine platelets whose surface binding, in response to agonists thrombin, calcium ionophore (A23187), phorbol esters and ADP, was similar. Adenosine Diphosphate 190-193 long intergenic non-protein coding RNA 1587 Homo sapiens 45-48 8358304-0 1993 [Formation of stabile complexes of myosin subfragment-1 with ADP and orthovanadate or beryllium fluoride in the presence of calcium ions]. Adenosine Diphosphate 61-64 myosin heavy chain 14 Homo sapiens 35-41 7682568-7 1993 Although G-CSF itself did not affect platelet aggregation in vitro, preincubation with G-CSF augmented a secondary aggregation of platelets induced by low concentrations of adenosine diphosphate (ADP). Adenosine Diphosphate 173-194 colony stimulating factor 3 Homo sapiens 87-92 7682568-7 1993 Although G-CSF itself did not affect platelet aggregation in vitro, preincubation with G-CSF augmented a secondary aggregation of platelets induced by low concentrations of adenosine diphosphate (ADP). Adenosine Diphosphate 196-199 colony stimulating factor 3 Homo sapiens 87-92 7682568-9 1993 Furthermore, the augmented ADP-induced secondary aggregation of platelets on G-CSF receptors was completely abrogated in the presence of anti-G-CSF polyclonal antibodies. Adenosine Diphosphate 27-30 colony stimulating factor 3 Homo sapiens 77-82 7682568-9 1993 Furthermore, the augmented ADP-induced secondary aggregation of platelets on G-CSF receptors was completely abrogated in the presence of anti-G-CSF polyclonal antibodies. Adenosine Diphosphate 27-30 colony stimulating factor 3 Homo sapiens 142-147 8384200-0 1993 Complexes of myosin subfragment 1 with pyrophosphate and with adenosine diphosphate as studied by phosphorus-31 nuclear magnetic resonance. Adenosine Diphosphate 62-83 myosin heavy chain 14 Homo sapiens 13-19 1332864-6 1992 Thus, CTx catalyzed ADP-ribosylation only perturbs in T alpha the GTP-binding domain, but not the conformational switch nor the domains of contact with the T beta gamma subunit, with Rh* and with the PDE. Adenosine Diphosphate 20-23 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 6-9 1333649-6 1992 Neutrophil elastase potentiation of platelet responses induced by low concentrations of cathepsin G was markedly inhibited by creatine phosphate/creatine phosphokinase and/or indomethacin, indicating that the synergism between elastase and cathepsin G required the participation of ADP and thromboxane A2. Adenosine Diphosphate 282-285 cathepsin G Homo sapiens 88-99 1406581-3 1992 [alpha-32P]ATP was cross-linked to the SopA protein by UV irradiation; this cross-linking was observed only in the presence of magnesium ion, and was competitively inhibited in the presence of non-radioactive ATP, ADP and dATP, but not other NTPs or dNTPs. Adenosine Diphosphate 214-217 plasmid-partitioning protein SopA Escherichia coli 39-43 1508200-7 1992 Consistent with these results, elongation factor 2 from the dph5 null mutant was found to have weak ADP-ribosyl acceptor activity, which was detectable only in the presence of high concentrations of fragment A. Adenosine Diphosphate 100-103 elongation factor 2 Saccharomyces cerevisiae S288C 31-50 1514576-10 1992 AMP deaminase binding to myosin also induced a marked resistance to orthophosphate inhibition (10 mM) in the presence of 50 microM ADP. Adenosine Diphosphate 131-134 myosin heavy chain 14 Homo sapiens 25-31 1634508-9 1992 This ADP-ribosylation was inhibited by rho GDI much more efficiently than by smg GDS. Adenosine Diphosphate 5-8 Rho GDP dissociation inhibitor alpha Homo sapiens 39-46 1385724-2 1992 The half-lives of both 6S and 10S myosin.MgADP.V(i) complexes in the dark at 0 degrees C are on the order of 2 weeks. Adenosine Diphosphate 41-46 myosin heavy chain 14 Homo sapiens 34-40 1534258-1 1992 Inhibition of the myosin subfragment 1 (S-1) ATPase activity by beryllium fluoride was studied directly in the presence of MgATP and following preincubation of samples with MgADP. Adenosine Diphosphate 173-178 myosin heavy chain 14 Homo sapiens 18-24 1534258-7 1992 The very different rates of inhibition in the presence of MgATP and on preincubation with MgADP suggested that beryllium fluoride binds to the M.ADP state of myosin. Adenosine Diphosphate 90-95 myosin heavy chain 14 Homo sapiens 158-164 1534258-7 1992 The very different rates of inhibition in the presence of MgATP and on preincubation with MgADP suggested that beryllium fluoride binds to the M.ADP state of myosin. Adenosine Diphosphate 92-95 myosin heavy chain 14 Homo sapiens 158-164 1534258-13 1992 It is concluded that M++.ADP.BeF3- is analogous to the M++.ADP.Vi and M**.ADP.Pi states of myosin. Adenosine Diphosphate 25-28 myosin heavy chain 14 Homo sapiens 91-97 1534258-13 1992 It is concluded that M++.ADP.BeF3- is analogous to the M++.ADP.Vi and M**.ADP.Pi states of myosin. Adenosine Diphosphate 59-62 myosin heavy chain 14 Homo sapiens 91-97 1534258-13 1992 It is concluded that M++.ADP.BeF3- is analogous to the M++.ADP.Vi and M**.ADP.Pi states of myosin. Adenosine Diphosphate 59-62 myosin heavy chain 14 Homo sapiens 91-97 1639763-8 1992 The response of trypsin-treated GDH to ADP and GTP was decreased compared with that of the native GDH. Adenosine Diphosphate 39-42 glutamate dehydrogenase 1 Homo sapiens 32-35 1558197-3 1992 None of the SH reagents tested affected the flow-induced EDRF release, but DTDP and NEM inhibited the release of EDRF stimulated by ADP, ionomycin, or poly-L-lysine. Adenosine Diphosphate 132-135 alpha hemoglobin stabilizing protein Homo sapiens 113-117 1740142-4 1992 The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively. Adenosine Diphosphate 21-24 actin, beta Gallus gallus 115-131 1740142-4 1992 The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively. Adenosine Diphosphate 21-24 actin, gamma 2, smooth muscle, enteric Gallus gallus 120-131 1740142-5 1992 The optimal pH for the ADP ribosylation was at pH 8.5, with the respective actin. Adenosine Diphosphate 23-26 actin, beta Gallus gallus 75-80 1733958-12 1992 Kinetic studies of the ADP-ribosylation and peptide mapping of the reaction products of rhoB p21 by EDIN and C3 suggest that the mode of action of the ADP-ribosylation by EDIN is quite similar to that by C3 and that the ADP-ribosylation site of rhoB p21 by EDIN is presumably the same as that by C3. Adenosine Diphosphate 23-26 H3 histone pseudogene 16 Homo sapiens 93-96 1733958-12 1992 Kinetic studies of the ADP-ribosylation and peptide mapping of the reaction products of rhoB p21 by EDIN and C3 suggest that the mode of action of the ADP-ribosylation by EDIN is quite similar to that by C3 and that the ADP-ribosylation site of rhoB p21 by EDIN is presumably the same as that by C3. Adenosine Diphosphate 151-154 H3 histone pseudogene 16 Homo sapiens 93-96 1733958-12 1992 Kinetic studies of the ADP-ribosylation and peptide mapping of the reaction products of rhoB p21 by EDIN and C3 suggest that the mode of action of the ADP-ribosylation by EDIN is quite similar to that by C3 and that the ADP-ribosylation site of rhoB p21 by EDIN is presumably the same as that by C3. Adenosine Diphosphate 151-154 H3 histone pseudogene 16 Homo sapiens 250-253 1613983-5 1992 Concentrations of act PAI, PAI ant and tPA/PAI complex dose-dependently increased with ADP. Adenosine Diphosphate 87-90 serpin family E member 1 Homo sapiens 22-25 1613983-5 1992 Concentrations of act PAI, PAI ant and tPA/PAI complex dose-dependently increased with ADP. Adenosine Diphosphate 87-90 serpin family E member 1 Homo sapiens 27-30 1613983-5 1992 Concentrations of act PAI, PAI ant and tPA/PAI complex dose-dependently increased with ADP. Adenosine Diphosphate 87-90 serpin family E member 1 Homo sapiens 27-30 1467434-5 1992 GMP-140 is a constituent of platelet alpha-granules, and a monoclonal antibody directed against this protein showed weak binding to platelets after 1 microM ADP stimulation. Adenosine Diphosphate 157-160 selectin P Homo sapiens 0-7 1301090-0 1992 [DTNB-light chain affects the conformation of the myosin head complexed with ADP and vanadate]. Adenosine Diphosphate 77-80 myosin heavy chain 14 Homo sapiens 50-56 1720468-6 1991 Treatment with ADP caused a dose-related increase in GMP-140 expression in both groups, without significant differences in this parameter between the groups at any given concentration. Adenosine Diphosphate 15-18 selectin P Homo sapiens 53-60 1832958-4 1991 The Gd3+ ion bound at the catalytic site inhibited decomposition of the ADP-sensitive phosphoenzyme. Adenosine Diphosphate 72-75 GRDX Homo sapiens 4-7 1832958-5 1991 (b) High-affinity binding of Gd3+ to site(s) distinct from both the transport site and the catalytic site inhibited the decomposition of the ADP-sensitive phosphoenzyme. Adenosine Diphosphate 141-144 GRDX Homo sapiens 29-32 1717069-7 1991 When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not. Adenosine Diphosphate 40-61 selectin P Homo sapiens 131-138 1651917-11 1991 Inhibition of rPRS I and rPRS II by 0.3 mM ADP was 87 and 54%, respectively, and inhibition by 1 mM GDP was 93 and 24%, respectively. Adenosine Diphosphate 43-46 phosphoribosyl pyrophosphate synthetase 1 Rattus norvegicus 14-32 1648103-7 1991 In pertussis toxin-treated K562 cell membranes supplemented with Gi-2, peptide 9 inhibited IGF-II-induced reduction in pertussis toxin-catalyzed ADP-ribosylation of Gi-2 with an IC50 of 30 microM. Adenosine Diphosphate 145-148 insulin like growth factor 2 Homo sapiens 91-97 1742357-4 1991 Prior ADP-ribosylation of EF-2 increased its ability to the phosphorylated. Adenosine Diphosphate 6-9 eukaryotic translation elongation factor 2 Homo sapiens 26-30 1646629-6 1991 7.7 to 7.2, log [ATP]/[ADP][Pi] at high pHi was significantly (P less than 0.02) greater than at low pHi. Adenosine Diphosphate 23-26 glucose-6-phosphate isomerase Rattus norvegicus 40-43 1902492-7 1991 ARF enhanced the LT-I-, LT-IIa-, and LT-IIb-catalyzed ADP ribosylation of agmatine, as well as the auto-ADP ribosylation of the toxin catalytic unit. Adenosine Diphosphate 54-57 colicin Ia immunity protein Escherichia coli 27-30 1960888-6 1991 Consequently, it was thought that AMCaADP was stiffer than AM and the crossbridges with either bound Ca (AMCa) or ADP (AM.ADP), the latter three kinds of the crossbridges being formed directly from AM, not as a result of ATP hydrolysis. Adenosine Diphosphate 38-41 WD and tetratricopeptide repeats 1 Homo sapiens 119-125 1865749-7 1991 The substrate-stimulated respiration of isolated liver mitochondria (ST4) was not affected by NaOCN, but the ADP-stimulated respiration (ST3) was reduced. Adenosine Diphosphate 109-112 matrix metallopeptidase 11 Mus musculus 137-140 1801377-0 1991 [The effect of Mg-ADP on the structural state of actin in the F-actin-myosin subfragment-1 complex]. Adenosine Diphosphate 15-21 myosin heavy chain 14 Homo sapiens 70-76 2124115-5 1990 wt., [32P]-ADP-ribosylated band of 140-160 kD which also showed immunoreactivity with antiserum to the PRL receptor. Adenosine Diphosphate 11-14 prolactin receptor Rattus norvegicus 103-115 2121532-0 1990 CTP-dependent endogenous ADP-ribosylation of a 38 kDa protein in HL-60 cell membranes. Adenosine Diphosphate 25-28 solute carrier family 25 member 1 Homo sapiens 0-3 2318895-8 1990 Also, similar to native yeast hexokinase, the fluorescent enhancement observed upon TNP-ATP binding to the synthetic peptide is greater than that observed upon TNP-ADP binding. Adenosine Diphosphate 164-167 hexokinase Saccharomyces cerevisiae S288C 30-40 1964035-3 1990 The ADP ribosylation catalysed by IAP was inhibited by the addition of Mg2+ to the reaction mixture. Adenosine Diphosphate 4-7 CD47 molecule Sus scrofa 34-37 34949666-1 2022 The regulation of poly(ADP-ribose) polymerase, the enzyme responsible for the synthesis of homopolymer ADP-ribose chains on nuclear proteins, has been extensively studied over the last decades for its involvement in tumorigenesis processes. Adenosine Diphosphate 103-106 Poly-(ADP-ribose) polymerase Drosophila melanogaster 18-45 34948316-4 2021 Adenosine is produced starting from the highly immunostimulatory ATP, which is progressively hydrolyzed to ADP and adenosine by CD39 and CD73. Adenosine Diphosphate 107-110 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 128-132 34840926-7 2021 The ADP-induced TRAP could be inhibited by clopidogrel a P2Y12 inhibitor. Adenosine Diphosphate 4-7 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 57-62 34812732-4 2021 The structures reveal a high flexibility of myosin in each state and provide valuable insights into the structural transitions of myosin-V upon ADP release and binding of AppNHp, as well as the actomyosin interface. Adenosine Diphosphate 144-147 myosin heavy chain 14 Homo sapiens 44-50 34789336-9 2021 Overexpressing NME6 reduces ADP-stimulated mitochondrial respiration and complex III abundance, thus linking NME6 to dysfunctional oxidative phosphorylation. Adenosine Diphosphate 28-31 NME/NM23 nucleoside diphosphate kinase 6 Homo sapiens 15-19 34789336-9 2021 Overexpressing NME6 reduces ADP-stimulated mitochondrial respiration and complex III abundance, thus linking NME6 to dysfunctional oxidative phosphorylation. Adenosine Diphosphate 28-31 NME/NM23 nucleoside diphosphate kinase 6 Homo sapiens 109-113 34575580-5 2021 The HSA-CD39 fusion protein is highly functional in degrading ATP and ADP, major pro-inflammatory reagents and platelet agonists. Adenosine Diphosphate 70-73 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 8-12 34571872-6 2021 Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 dephosphorylates ATP to ADP and to AMP, which in turn, is hydrolysed to adenosine by ecto-5"-nucleotidase (CD73). Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-48 34571872-6 2021 Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 dephosphorylates ATP to ADP and to AMP, which in turn, is hydrolysed to adenosine by ecto-5"-nucleotidase (CD73). Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 50-58 34571872-6 2021 Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase1)/CD39 dephosphorylates ATP to ADP and to AMP, which in turn, is hydrolysed to adenosine by ecto-5"-nucleotidase (CD73). Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 60-64 34575427-8 2021 Docking investigation revealed that the drug binds to the ADP/ATP sites on KIR6.1/2 and SUR2A/B and on the sulfonylureas site showing low binding energy <6 Kcal/mol for the KIR6.1/2-SUR2 subunits vs. the <4 Kcal/mol for the KIR6.2-SUR1. Adenosine Diphosphate 58-61 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 75-83 34575427-8 2021 Docking investigation revealed that the drug binds to the ADP/ATP sites on KIR6.1/2 and SUR2A/B and on the sulfonylureas site showing low binding energy <6 Kcal/mol for the KIR6.1/2-SUR2 subunits vs. the <4 Kcal/mol for the KIR6.2-SUR1. Adenosine Diphosphate 58-61 potassium inwardly rectifying channel subfamily J member 8 Homo sapiens 173-181 34264659-2 2021 Histones, particularly H3 and H2B, are major targets of ADP-ribosylation and are primarily modified on serine with a single ADP-ribose unit following DNA damage. Adenosine Diphosphate 56-59 H2B clustered histone 21 Homo sapiens 30-33 34264659-6 2021 These studies revealed that ADP-ribosylation of serine-6 of histone H2B (H2BS6ADPr) inhibits chromatin folding and higher-order organization; notably, this effect was enhanced by ADP-ribosylation of H3S10. Adenosine Diphosphate 28-31 H2B clustered histone 21 Homo sapiens 73-82 34264659-6 2021 These studies revealed that ADP-ribosylation of serine-6 of histone H2B (H2BS6ADPr) inhibits chromatin folding and higher-order organization; notably, this effect was enhanced by ADP-ribosylation of H3S10. Adenosine Diphosphate 179-182 H2B clustered histone 21 Homo sapiens 73-82 34171934-5 2022 Platelets release IL-1beta within minutes in response to adenosine diphosphate (ADP), collagen, and thrombin receptor agonists, but not in response to conventional NLRP3 inflammasome agonists-lipopolysaccharide and adenosine triphosphate. Adenosine Diphosphate 80-83 interleukin 1 alpha Homo sapiens 18-26 34108583-4 2021 We demonstrated that storage of whole blood in a polyolefin bag maintained ADP-induced aggregation rates at more than twofold higher than those in a polyvinyl chloride bag, and also significantly suppressed P-selectin expression, a platelet activation marker (ADP-induced aggregation rates: 24.6 +- 5.1% vs. 51.7 +- 11.5%, p = 0.002; P-selectin expression; 50.3 +- 8.4MFI vs. 31.6 +- 9.3MFI, p = 0.018). Adenosine Diphosphate 260-263 selectin P Homo sapiens 207-217 35514261-1 2022 Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively. Adenosine Diphosphate 46-49 purinergic receptor P2Y1 Homo sapiens 104-108 35514261-10 2022 These data suggest that ADP-induced Rap1b activation requires both P2Y1 and P2Y12. Adenosine Diphosphate 24-27 purinergic receptor P2Y1 Homo sapiens 67-71 35353230-9 2022 We were able to detect P2Y12 in LSK, implicating a direct effect of ADP on LSK via P2Y12 signaling. Adenosine Diphosphate 68-71 purinergic receptor P2Y, G-protein coupled 12 Mus musculus 83-88 2557776-8 1989 The effect of ethanol on PAF-induced platelet aggregation shows a selectivity similar to that demonstrated by other investigators for epinephrine and adenosine diphosphate. Adenosine Diphosphate 150-171 PCNA clamp associated factor Homo sapiens 25-28 2557904-3 1989 CapZ inhibits the polymerization of ATP-actin onto filament ends with ATP subunits slightly less than onto ends with ADP subunits, and onto ends with ADP-BeF3- subunits about as much as ends with ADP subunits. Adenosine Diphosphate 117-120 capping actin protein of muscle Z-line alpha subunit 2 Gallus gallus 0-4 2557904-3 1989 CapZ inhibits the polymerization of ATP-actin onto filament ends with ATP subunits slightly less than onto ends with ADP subunits, and onto ends with ADP-BeF3- subunits about as much as ends with ADP subunits. Adenosine Diphosphate 150-153 capping actin protein of muscle Z-line alpha subunit 2 Gallus gallus 0-4 2557904-3 1989 CapZ inhibits the polymerization of ATP-actin onto filament ends with ATP subunits slightly less than onto ends with ADP subunits, and onto ends with ADP-BeF3- subunits about as much as ends with ADP subunits. Adenosine Diphosphate 150-153 capping actin protein of muscle Z-line alpha subunit 2 Gallus gallus 0-4 2531615-3 1989 Which consists in the stabilization of the myosin-MgADP complex in the enzyme active center by way of cross-linking of the active center with a Co-phenanthroline complex simultaneously interacting with two SH-groups of the protein. Adenosine Diphosphate 50-55 myosin heavy chain 14 Homo sapiens 43-49 2531615-4 1989 Myosin with protected active center completely loses its ability to hydrolyze ATP; however, it can be reactivated by way of SH-group reduction with a subsequent MgADP release from the active centers. Adenosine Diphosphate 161-166 myosin heavy chain 14 Homo sapiens 0-6 2762319-5 1989 However, actin filaments together with 1 mM ADP abolish myosin assembly. Adenosine Diphosphate 44-47 myosin heavy chain 14 Homo sapiens 56-62 2762319-10 1989 In ADP, myosin monomers rapidly decorate F-actin, preventing extensive formation of thick filaments. Adenosine Diphosphate 3-6 myosin heavy chain 14 Homo sapiens 8-14 2523928-7 1989 Treatment of B8P3.11 with pertussis toxin, at concentrations which ADP-ribosylate GTP-binding proteins, inhibits IL-2 secretion. Adenosine Diphosphate 67-70 interleukin 2 Mus musculus 113-117 2526354-1 1989 Myosin Ca2+-ATPase activity decreased in the presence of ADP. Adenosine Diphosphate 57-60 myosin heavy chain 14 Homo sapiens 0-6 2524474-2 1989 The amount of total nucleotides (ADP + ATP) bound to myofibrils, determined by a centrifugation method or a rapid filtration method, was 0.86 mol/mol myosin head. Adenosine Diphosphate 33-36 myosin heavy chain 14 Homo sapiens 150-156 2524474-3 1989 The amount of bound ADP, determined as the ADP remaining in the mixture after free ADP had been rapidly converted into ATP by an ATP-regenerating system, was found to be 0.67 mol/mol myosin head. Adenosine Diphosphate 20-23 myosin heavy chain 14 Homo sapiens 183-189 2524474-3 1989 The amount of bound ADP, determined as the ADP remaining in the mixture after free ADP had been rapidly converted into ATP by an ATP-regenerating system, was found to be 0.67 mol/mol myosin head. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 183-189 2524474-3 1989 The amount of bound ADP, determined as the ADP remaining in the mixture after free ADP had been rapidly converted into ATP by an ATP-regenerating system, was found to be 0.67 mol/mol myosin head. Adenosine Diphosphate 43-46 myosin heavy chain 14 Homo sapiens 183-189 2842188-1 1988 Pretreatment of rat cardiac myocytes with the beta-adrenergic agonist, db-cAMP or forskolin decreased ADP-ribosylation of 40-41 kDa protein by islet-activating protein (IAP) in cell membranes. Adenosine Diphosphate 102-105 magnesium transporter 1 Rattus norvegicus 143-167 2842188-1 1988 Pretreatment of rat cardiac myocytes with the beta-adrenergic agonist, db-cAMP or forskolin decreased ADP-ribosylation of 40-41 kDa protein by islet-activating protein (IAP) in cell membranes. Adenosine Diphosphate 102-105 magnesium transporter 1 Rattus norvegicus 169-172 2842188-2 1988 Addition of activated cyclic AMP-dependent protein kinase (protein kinase A) catalytic subunit and MgCl2 also decreased ADP-ribosylation of 40-41 kDa protein by IAP in cell membranes. Adenosine Diphosphate 120-123 magnesium transporter 1 Rattus norvegicus 161-164 2842188-5 1988 These show that phosphorylation of Gi by protein kinase A results in a decrease in its ADP-ribosylation by IAP. Adenosine Diphosphate 87-90 magnesium transporter 1 Rattus norvegicus 107-110 2977405-3 1988 At the same time, a platelet-activating factor (PAF) and an unidentified factor that inhibited the aggregation of rabbit platelets induced by PAF, arachidonic acid or ADP were detected in the ipsilateral renal venous blood, but were not found in the contralateral renal venous blood. Adenosine Diphosphate 167-170 PCNA clamp associated factor Homo sapiens 48-51 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 32-35 myosin heavy chain 14 Homo sapiens 102-108 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 32-35 myosin heavy chain 14 Homo sapiens 188-194 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 271-274 myosin heavy chain 14 Homo sapiens 102-108 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 271-274 myosin heavy chain 14 Homo sapiens 188-194 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 271-274 myosin heavy chain 14 Homo sapiens 102-108 2464615-7 1988 Stable analogues of M.ATP and M.ADP.Pi, the predominant complexes present during hydrolysis of ATP by myosin, were prepared by crosslinking the two reactive SH groups (SH1 and SH2) in the myosin head heavy chain with N,N"-p-phenylenedimaleimide (pPDM) in the presence of ADP, and by forming a complex with vanadate ion and ADP. Adenosine Diphosphate 271-274 myosin heavy chain 14 Homo sapiens 188-194 2967885-10 1988 In addition, if Ca2+ activates the ATPase by allowing for the strong attachment of the myosin to actin in an A.M.ADP.Pi state, it could do so before Pi release. Adenosine Diphosphate 113-116 myosin heavy chain 14 Homo sapiens 87-93 2967287-6 1988 Myosin bound 0.5 mol of nucleotides (ATP and ADP) with high affinity (Kd congruent to 1 microM) and 0.35 mol of nucleotides with low affinity (Kd = 24 microM) for ATP. Adenosine Diphosphate 45-48 myosin heavy chain 14 Homo sapiens 0-6 2970212-7 1988 By contrast, the myosin intermediate with hydrolysis products (ADP + Pi) is stabilized by a large increase in entropy. Adenosine Diphosphate 63-66 myosin heavy chain 14 Homo sapiens 17-23 24226076-3 1987 These observations led to the proposal that nitrate reductase is a regulatory enzyme with ADP acting as a negative effector. Adenosine Diphosphate 90-93 nitrate reductase [NADH] 1 Zea mays 44-61 24226076-4 1987 The effect of ADP on the invitro activity of nitrate reductase and the changes in the in-vivo adenylate pool under dark-N2 and dark-O2 were investigated. Adenosine Diphosphate 14-17 nitrate reductase [NADH] 1 Zea mays 45-62 24226076-5 1987 It was found that ADP inhibited the activity of partially purified nitrate reductase. Adenosine Diphosphate 18-21 nitrate reductase [NADH] 1 Zea mays 67-84 3122357-5 1987 Sodium arachidonate (NaAA)-induced PA was inhibited by 125 mg ASA in all tested methods; since inhibition of ADP-induced PA was not observed in NWB or CWB and the impedance methods failed to show a second wave of ADP-induced PA the significance of the second wave appears doubtful. Adenosine Diphosphate 109-112 N-acylethanolamine acid amidase Homo sapiens 21-25 2961218-4 1987 At low PAF concentrations aggregation and BTG release were blocked by apyrase (a scavenger of ADP), by ASA (an inhibitor of cyclooxygenase) and by BM 13177 (a thromboxane receptor antagonist). Adenosine Diphosphate 94-97 PCNA clamp associated factor Homo sapiens 7-10 3297204-8 1987 With gel-filtered platelets, there was a direct correlation between ADP-induced biotin-PAC1 binding and binding determined in a conventional 125I-PAC1 binding assay (r = .99; P less than .001). Adenosine Diphosphate 68-71 ADCYAP receptor type I Homo sapiens 87-91 3297204-8 1987 With gel-filtered platelets, there was a direct correlation between ADP-induced biotin-PAC1 binding and binding determined in a conventional 125I-PAC1 binding assay (r = .99; P less than .001). Adenosine Diphosphate 68-71 ADCYAP receptor type I Homo sapiens 146-150 3297204-12 1987 Low concentrations of ADP and epinephrine, which induce fibrinogen receptors but little secretion, stimulated near-maximal PAC1 binding but little S12 binding. Adenosine Diphosphate 22-25 ADCYAP receptor type I Homo sapiens 123-127 3111525-6 1987 Activation of intact platelets by thrombin, adenosine 5"-diphosphate, and collagen under conditions which promote platelet aggregation (i.e., stirring with extracellular Ca2+) also resulted in limited proteolysis of calmodulin-binding proteins including those labeled with antisera against myosin light chain kinase and the calmodulin-dependent phosphatase. Adenosine Diphosphate 44-68 myosin light chain kinase Homo sapiens 290-315 3827975-0 1987 Beta 2-glycoprotein-I (apo-H) inhibits the release reaction of human platelets during ADP-induced aggregation. Adenosine Diphosphate 86-89 apolipoprotein H Homo sapiens 23-28 3663016-13 1987 The common bioenergetic pattern in all types of muscles is consistent with a graded increase in ADP concentration (from below to well above the apparent Km for nucleotide translocase ANT) with increasing work as a regulator of mitochondrial respiration. Adenosine Diphosphate 96-99 solute carrier family 25 member 6 Homo sapiens 183-186 2879895-7 1987 An abundant GTP binding protein, detected by ADP-ribosylation with pertussis toxin, was also widely distributed in the neuron. Adenosine Diphosphate 45-48 hydroxycarboxylic acid receptor 3 Homo sapiens 12-31 3792312-4 1986 Cycloheximide treatment and incubation at reduced temperatures also reduced the rate of protein synthesis and stimulated the ADP-ribosylation of P80. Adenosine Diphosphate 125-128 coilin Mus musculus 145-148 3792312-5 1986 Starvation-dependent ADP-ribosylation of P80 was shown to occur in three other cell lines (Chang, Neuro-2a, and chick comb fibroblasts). Adenosine Diphosphate 21-24 coilin Mus musculus 41-44 3785292-4 1986 PDHa kinase activity is inhibited by ADP, thiamine pyrophosphate, and physiological levels of pyruvate and propionate. Adenosine Diphosphate 37-40 pyruvate dehydrogenase E1 subunit alpha 1 Homo sapiens 0-4 3011038-7 1986 In the case of CP + adenosine nucleotides (ATP or ADP), myokinase activity decreased the rate of tension development which was statistically significant after 5-7 sec of contraction. Adenosine Diphosphate 50-53 adenylate kinase isoenzyme 1 Oryctolagus cuniculus 56-65 3005295-5 1986 Both kinetic and equilibrium measurements demonstrate that the critical concentration of gelsolin-capped ADP-actin filaments (8 microM in 1 mM MgCl2 and 0.2 mM ADP) is the same as for the uncapped filaments, proving that the critical concentration is the same at both ends of the equilibrium polymer in ADP as predicted by theory. Adenosine Diphosphate 105-108 gelsolin Homo sapiens 89-97 3005295-5 1986 Both kinetic and equilibrium measurements demonstrate that the critical concentration of gelsolin-capped ADP-actin filaments (8 microM in 1 mM MgCl2 and 0.2 mM ADP) is the same as for the uncapped filaments, proving that the critical concentration is the same at both ends of the equilibrium polymer in ADP as predicted by theory. Adenosine Diphosphate 160-163 gelsolin Homo sapiens 89-97 3705019-4 1986 Stimulation with a low dose of thrombin (0.001 U/ml) or ADP (10 microM) caused a change in shape and incorporation of ABP, myosin, and actin, but not serotonin secretion. Adenosine Diphosphate 56-59 actin Oryctolagus cuniculus 135-140 3706054-0 1986 Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. Adenosine Diphosphate 16-19 PCNA clamp associated factor Homo sapiens 76-102 3706054-0 1986 Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. Adenosine Diphosphate 16-19 PCNA clamp associated factor Homo sapiens 104-107 3706054-1 1986 Platelet Activating Factor (PAF)-induced human platelet aggregation in citrated plasma is accompanied by activation of the cyclo-oxygenase pathway and release of intracellular constituents including Adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 199-223 PCNA clamp associated factor Homo sapiens 0-26 3706054-1 1986 Platelet Activating Factor (PAF)-induced human platelet aggregation in citrated plasma is accompanied by activation of the cyclo-oxygenase pathway and release of intracellular constituents including Adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 199-223 PCNA clamp associated factor Homo sapiens 28-31 3706054-1 1986 Platelet Activating Factor (PAF)-induced human platelet aggregation in citrated plasma is accompanied by activation of the cyclo-oxygenase pathway and release of intracellular constituents including Adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 225-228 PCNA clamp associated factor Homo sapiens 0-26 3706054-1 1986 Platelet Activating Factor (PAF)-induced human platelet aggregation in citrated plasma is accompanied by activation of the cyclo-oxygenase pathway and release of intracellular constituents including Adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 225-228 PCNA clamp associated factor Homo sapiens 28-31 3706054-3 1986 Removal of ADP by enzymatic systems had little or no effect on PAF-induced full aggregation, but reversed the aggregating effect of PAF (at 10 times threshold concentrations) on "aspirinated" platelets. Adenosine Diphosphate 11-14 PCNA clamp associated factor Homo sapiens 132-135 3706054-6 1986 Thus, ADP may amplify the primary response to PAF but its role is modulated by the availability of the cyclo-oxygenase pathway products. Adenosine Diphosphate 6-9 PCNA clamp associated factor Homo sapiens 46-49 3963768-3 1986 Platelet GDH from these patients and controls was regularly inactivated by 2 mM guanosine-5"-triphosphate (GTP) and simulated one- to twofold by 2 mM adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 150-174 glutamate dehydrogenase 1 Homo sapiens 9-12 3963768-3 1986 Platelet GDH from these patients and controls was regularly inactivated by 2 mM guanosine-5"-triphosphate (GTP) and simulated one- to twofold by 2 mM adenosine-5"-diphosphate (ADP). Adenosine Diphosphate 176-179 glutamate dehydrogenase 1 Homo sapiens 9-12 3633700-5 1986 The actin X myosin X ADP intermediate formed at the active site during the cross-bridge cycle is suggested as the site of action of Vi. Adenosine Diphosphate 21-24 unconventional myosin-X Cavia porcellus 12-20 3838041-2 1985 Work in our laboratory has shown that dialdehyde-ADP (oADP) can be used as an affinity label of rabbit muscle pyruvate kinase: if the enzyme is incubated with cold oADP in the presence of high ADP concentrations, dialyzed and then incubated with 14C-oADP, the enzyme inactivates and one mole of radioactive oADP incorporates per mole of enzyme subunit. Adenosine Diphosphate 49-52 pyruvate kinase PKLR Oryctolagus cuniculus 110-125 2934863-4 1985 Both prior to and after ASA ingestion ADP removal by creatine phosphate/creatine phosphokinase (CP/CPK) resulted in a reduced, reversible platelet aggregation induced by PAF alone or in combination with the other agonists. Adenosine Diphosphate 38-41 PCNA clamp associated factor Homo sapiens 170-173 2934863-7 1985 It is concluded that not only the activation of human platelets by low doses of PAF itself, but also the synergism of PAF and other platelet agonists is highly dependent upon ADP and products of the cyclooxygenase pathway. Adenosine Diphosphate 175-178 PCNA clamp associated factor Homo sapiens 80-83 2934863-7 1985 It is concluded that not only the activation of human platelets by low doses of PAF itself, but also the synergism of PAF and other platelet agonists is highly dependent upon ADP and products of the cyclooxygenase pathway. Adenosine Diphosphate 175-178 PCNA clamp associated factor Homo sapiens 118-121 2994487-6 1985 Furthermore, steady-state contraction induced by ADP was associated with a maintained elevation in the level of myosin phosphorylation. Adenosine Diphosphate 49-52 myosin heavy chain 14 Homo sapiens 112-118 3162018-2 1985 Pyruvate kinase and lactate dehydrogenase were used to link adenosine diphosphate formation to oxidation of nicotinamide adenine dinucleotide which was followed by the change in absorption at 340 nm. Adenosine Diphosphate 60-81 pyruvate kinase PKLR Oryctolagus cuniculus 0-15 2991534-1 1985 Molecular movements generated in the heavy-chain regions (27-50-20(X 10(3)) Mr) of myosin S1 on interaction with nucleotides ATP, AMPPNP, ADP and PPi were investigated by limited proteolysis of several enzyme-metal nucleotide complexes in the absence and presence of reversibly bound and crosslinked F-actin. Adenosine Diphosphate 138-141 myosin heavy chain 14 Homo sapiens 83-89 4003756-5 1985 When dimeric bovine seminal RNase was monomerized in advance by treatment with dithiothreitol and urea, the enzyme lost ADP-ribose-accepting ability in spite of a significant residual enzyme activity. Adenosine Diphosphate 120-123 seminal ribonuclease Bos taurus 20-33 3832867-6 1985 Mepacrine or PAF superfusion causes large thrombotic masses, as compared to control, ADP induced thrombi, and seems toxic for the endothelial cells. Adenosine Diphosphate 85-88 PCNA clamp associated factor Homo sapiens 13-16 3991494-4 1985 These events were concomitant with the occurrence of PMN aggregating activity in the supernatants due to the release of NCP, as it was antagonised (30-40%) by a rabbit anti-human NCP, and to the release of PAF which also accounted for the platelet aggregating activity that was independent from both adenosine diphosphate and cyclo-oxygenase inhibitors. Adenosine Diphosphate 300-321 PCNA clamp associated factor Homo sapiens 206-209 6096373-4 1984 Incubation of hepatocyte membranes with [alpha-32P]NAD and the preactivated A-protomer (an active component) of islet-activating protein (IAP), pertussis toxin, resulted in the ADP-ribosylation of a specific IAP substrate protein (Mr = 41,000). Adenosine Diphosphate 177-180 magnesium transporter 1 Rattus norvegicus 112-136 6096373-4 1984 Incubation of hepatocyte membranes with [alpha-32P]NAD and the preactivated A-protomer (an active component) of islet-activating protein (IAP), pertussis toxin, resulted in the ADP-ribosylation of a specific IAP substrate protein (Mr = 41,000). Adenosine Diphosphate 177-180 magnesium transporter 1 Rattus norvegicus 138-141 6096373-4 1984 Incubation of hepatocyte membranes with [alpha-32P]NAD and the preactivated A-protomer (an active component) of islet-activating protein (IAP), pertussis toxin, resulted in the ADP-ribosylation of a specific IAP substrate protein (Mr = 41,000). Adenosine Diphosphate 177-180 magnesium transporter 1 Rattus norvegicus 208-211 6434224-2 1984 Before CSII and compared with results obtained on samples from age- and sex-matched control subjects, there was enhanced reactivity of the platelets from diabetic patients to ADP, collagen and sodium arachidonate (NaAA). Adenosine Diphosphate 175-178 N-acylethanolamine acid amidase Homo sapiens 214-218 6091666-2 1984 Platelet aggregation, [14C]-5HT and TxB2 release induced by "threshold" and "supramaximal" concentrations of ADP, adrenaline, platelet-activating factor (PAF) and U46619 were totally abolished by low concentrations of PGI2 (3-6 nM). Adenosine Diphosphate 109-112 PCNA clamp associated factor Homo sapiens 126-152 6091666-4 1984 PAF-induced release reaction like that induced by ADP and adrenaline was totally dependent on the cyclooxygenase products and aggregation, while U46619-induced release reaction was only partially dependent on aggregation and the cyclooxygenase products. Adenosine Diphosphate 50-53 PCNA clamp associated factor Homo sapiens 0-3 6431801-2 1984 Irreversible aggregation and 14C-serotonin secretion in response to PAF (10(-5) M) was found to be dependent on both thromboxane production and secreted adenosine diphosphate (ADP). Adenosine Diphosphate 153-174 PCNA clamp associated factor Homo sapiens 68-71 6431801-2 1984 Irreversible aggregation and 14C-serotonin secretion in response to PAF (10(-5) M) was found to be dependent on both thromboxane production and secreted adenosine diphosphate (ADP). Adenosine Diphosphate 176-179 PCNA clamp associated factor Homo sapiens 68-71 6466641-8 1984 It is proposed that the 6-[(4-bromo-2,3-dioxobutyl)thio]-6-deaminoadenine nucleotides react at the active site of pyruvate kinase and at the ADP activating site of isocitrate dehydrogenase and that these compounds may have general applicability as affinity labels of catalytic and regulatory adenine nucleotide sites in proteins. Adenosine Diphosphate 141-144 pyruvate kinase PKLR Oryctolagus cuniculus 114-129 6086335-2 1984 The adenylate kinase isoenzyme located in the intermembrane space of mitochondria, AK2, is a monomeric protein of Mr 30000 which catalyzes the reaction ATP + AMP + AMP in equilibrium 2 ADP. Adenosine Diphosphate 185-188 adenylate kinase 2 Bos taurus 83-86 6693491-7 1984 Elongation factor-2 of all the hybrids was susceptible to ADP-ribosylation by fragment A of diphtheria toxin. Adenosine Diphosphate 58-61 eukaryotic translation elongation factor 2 Mus musculus 0-19 6227332-3 1983 One of these anti-GP-IIIa antibodies (C17) inhibited both ADP- and collagen-induced platelet aggregation as well as ADP-induced fibrinogen binding to platelets. Adenosine Diphosphate 58-61 cytokine like 1 Homo sapiens 38-41 6227332-3 1983 One of these anti-GP-IIIa antibodies (C17) inhibited both ADP- and collagen-induced platelet aggregation as well as ADP-induced fibrinogen binding to platelets. Adenosine Diphosphate 116-119 cytokine like 1 Homo sapiens 38-41 6317121-6 1983 The partial stereoselectivity of the P2-purinoceptor in smooth muscle contrasts with the absolute stereospecificity of P1-purinoceptors for adenosine on smooth muscle and autonomic nerve terminals and the absolute stereospecificity of the receptor for ADP on the human platelet. Adenosine Diphosphate 252-255 pyrimidinergic receptor P2Y6 Homo sapiens 37-52 6751401-1 1982 Yeast hexokinase B (ATP:-hexose 6-phosphotransferase, EC 2.7.1.1) was crystallized in the presence of D-xylose and ADP, and its structure was determined at 7 A resolution. Adenosine Diphosphate 115-118 hexokinase Saccharomyces cerevisiae S288C 6-16 7202009-1 1982 The exchange of actin filament subunits for unpolymerized actin or for subunits in other filaments has been quantitated by three experimental techniques: fluorescence energy transfer, incorporation of 35S-labeled actin monomers into unlabeled actin filaments, and exchange of [14C]ATP with filament-bound ADP. Adenosine Diphosphate 305-308 actin Oryctolagus cuniculus 16-21 7122212-4 1982 Fetal red cell PK differed from the adult enzyme by its greater thermostability, lower affinities for phosphoenolpyruvate and ADP, higher nucleotide specificity and lower ATP inhibition. Adenosine Diphosphate 126-129 pyruvate kinase PKLR Oryctolagus cuniculus 15-17 7104366-1 1982 Periodate-oxidized ADP (dialdehyde-ADP) inactivates rabbit muscle pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC 2.7.1.40) and combines irreversibly to the enzyme. Adenosine Diphosphate 19-22 pyruvate kinase PKLR Oryctolagus cuniculus 66-81 7104366-1 1982 Periodate-oxidized ADP (dialdehyde-ADP) inactivates rabbit muscle pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC 2.7.1.40) and combines irreversibly to the enzyme. Adenosine Diphosphate 19-22 pyruvate kinase PKM Oryctolagus cuniculus 83-118 7104366-9 1982 From the evidence presented it is concluded: (1) dialdehyde-ADP behaves as an affinity label of rabbit muscle pyruvate kinase; (2) the inactivator binds probably to lysine residues at or near the active site, forming morpholine-like structures, and (3) the enzyme possesses two modifiable groups essential for activity, the reaction of one of them being sufficient to cause total loss in activity. Adenosine Diphosphate 60-63 pyruvate kinase PKLR Oryctolagus cuniculus 110-125 6765171-7 1982 Microtubule-associated proteins (MAP1 and MAP2) of high molecular weight were also shown to undergo ADP-ribosylation. Adenosine Diphosphate 100-103 Blood pressure QTL 196 Rattus norvegicus 33-37 6765171-7 1982 Microtubule-associated proteins (MAP1 and MAP2) of high molecular weight were also shown to undergo ADP-ribosylation. Adenosine Diphosphate 100-103 microtubule-associated protein 2 Rattus norvegicus 42-46 6277628-5 1982 Likewise, addition of PPi, ATP or ADP created a greater mobility in the spin label when added to ventricular spin-labeled myosin as compared to that of atrial myosin. Adenosine Diphosphate 34-37 myosin heavy chain 14 Homo sapiens 122-128 6459580-2 1982 The association constant of the stable complex M.ADP.Vi, in which M indicates myosin [Goodno, C. C. (1979) Proc. Adenosine Diphosphate 49-52 myosin heavy chain 14 Homo sapiens 78-84 6459580-13 1982 The activation of ligand release (ratio of rate of dissociation of ADP and vanadate from actomyosin relative to myosin) is much larger than the activation of myosin ATPase by actin, whereas the actual rates of the reactions are much slower. Adenosine Diphosphate 67-70 myosin heavy chain 14 Homo sapiens 93-99 6269776-3 1981 Exposure of cultured neuroblastoma cells to LPS produced rapid changes in the regulatory parameters of energy metabolism, an oxidation of intramitochondrial pyridine nucleotides, and a decline in cellular [ATP]/[ADP] [Pi], which were followed by alterations in mitochondrial morphology. Adenosine Diphosphate 212-215 Rho guanine nucleotide exchange factor (GEF) 16 Mus musculus 21-34 6447696-2 1980 Myosin has been modified with near stoichiometric amounts of the bifunctional reagent [14C]p-N,N"-phenylenedimaleimide (pPDM) in the presence of MgADP under conditions which abolish its ATPase activity. Adenosine Diphosphate 145-150 myosin heavy chain 14 Homo sapiens 0-6 6447477-0 1980 Nucleotide-induced conformations of myosin: a comparison of states formed with Mg epsilon ADP. Adenosine Diphosphate 90-93 myosin heavy chain 14 Homo sapiens 36-42 6893608-0 1980 Conformational changes of F-actin-epsilon-ADP in thin filaments in myosin-free muscle fibers induced by Ca2+. Adenosine Diphosphate 41-45 myosin heavy chain 14 Homo sapiens 67-73 6445761-1 1980 Mixed anhydrids of AMP, ADP, ATP and IMP and mesitylene carboxylic acid (AMP-MC, ADP-MC, ATP-MC and IMP-MC) are efficient irreversible inhibitors of the Ca-ATPase activity of myosin and heavy meromyosin. Adenosine Diphosphate 24-27 myosin heavy chain 14 Homo sapiens 175-181 6892994-5 1980 Addition of ADP and Pi to myosin results in the formation of an equilibrium amount of enzyme-bound ATP. Adenosine Diphosphate 12-15 myosin heavy chain 14 Homo sapiens 26-32 7229020-1 1980 The five possible analogues of ATP and the three possible analogues of ADP which contain single non-bridging sulphur atoms instead of oxygen in the polyphosphate structure have been used as probes of the interaction of nucleotides with myosin and actomyosin. Adenosine Diphosphate 71-74 myosin heavy chain 14 Homo sapiens 236-242 6450508-3 1980 ADP is a competitive inhibitor, like myosin ATPase, and with practically the same inhibitor constant. Adenosine Diphosphate 0-3 myosin heavy chain 14 Homo sapiens 37-43 233578-1 1979 The interaction of CrADP, an exchange-inert paramagnetic analogue of Mg-ADP, with yeast hexokinase has been studied by measuring the effects of CrADP on the longitudinal nuclear relaxation rate (1/T1) of the protons of water and the protons and phosphorus atom of enzyme-bound glucose-6-P. Adenosine Diphosphate 69-75 hexokinase Saccharomyces cerevisiae S288C 88-98 210972-2 1978 ECM incubated with lipoprotein-deficient plasma (LDP) for 2 hours at 37 degrees C had an inhibitory effect on ADP- and collagen-induced platelet aggregation and prostaglandin production in platelet-rich plasma similar to that observed when ECM were preincubated with growth medium or plasma. Adenosine Diphosphate 110-113 multimerin 1 Homo sapiens 0-3 708753-2 1978 About 1.65 +/- 0.15 mol MgADP and 1.9 +/- 0.1 mol CaADP were bound per mol myosin. Adenosine Diphosphate 24-29 myosin heavy chain 14 Homo sapiens 75-81 708753-8 1978 Also, the free energy of MgADP binding to cardiac myosin is similar to values reported for skeletal myosin. Adenosine Diphosphate 25-30 myosin heavy chain 14 Homo sapiens 50-56 151558-2 1978 Ki (ADP) of myosin ATPase of pigeon is higher, but the Km (ATP) is lower than that of fowl. Adenosine Diphosphate 4-7 myosin heavy chain 14 Homo sapiens 12-18 362511-13 1978 ADP-induced platelet aggregation (PA) was always reduced by ECM, but significantly less in groups II and III. Adenosine Diphosphate 0-3 multimerin 1 Homo sapiens 60-63 362511-17 1978 Platelet factor 3 activity, measured after exposure of PRP to ADP, was significantly reduced by ECM, but was significantly less in groups II, III, and V than in group I. Adenosine Diphosphate 62-65 multimerin 1 Homo sapiens 96-99 641045-1 1978 The time course of oxygen-18 exchange between [18O]Pi and normal water, catalyzed by myosin subfragment 1 in the presence of MgADP, was followed using the shift in 31P NMR caused by the presence of oxygen-18 bound to the phosphorus. Adenosine Diphosphate 125-130 myosin heavy chain 14 Homo sapiens 85-91 415004-0 1978 Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2. Adenosine Diphosphate 91-112 eukaryotic translation elongation factor 2 Mus musculus 129-148 409788-2 1977 Pseudomonas toxin was assayed by measurement of its ability to catalyze the transfer of radioactivity from [14C]adenine-labeled nicotinamide adenine dinucleotide to elongation factor 2 (adenosine diphosphate ribosylation activity). Adenosine Diphosphate 186-207 eukaryotic translation elongation factor 2 Mus musculus 165-184 193485-3 1977 One mole of MG-ADP binds with high affinity (K approximately equal to 10(6) M-1) and subsequently a second with lower affinity (K approximately equal to 10(2)-10(4) M-1) per myosin. Adenosine Diphosphate 12-18 myosin heavy chain 14 Homo sapiens 174-180 193485-4 1977 Only one mole of MG-ADP was found to bind with the high affinity to isolated myosin heads. Adenosine Diphosphate 17-23 myosin heavy chain 14 Homo sapiens 77-83 193485-5 1977 This implies that binding of MG-ADP to intact myosin exhibits negative cooperativity. Adenosine Diphosphate 29-35 myosin heavy chain 14 Homo sapiens 46-52 140864-6 1977 This visualization of Gd3+ is apparently dependent on two factors: (i) the presence of ATP, ADP being ineffective; (ii) sufficient time for most of the ATP to be hydrolysed. Adenosine Diphosphate 92-95 GRDX Homo sapiens 22-25 138447-6 1977 On addition of ATP or ADP a blueshift was observed in the fluorescent emission spectrum of beta-naphthoquinone-4-sulfonate bound by myosin, presumably owing to conformational changes in the environment of essential amino groups induced by the binding of nucleotides. Adenosine Diphosphate 22-25 myosin heavy chain 14 Homo sapiens 132-138 1009117-1 1976 Various analogues of adenosine 5"-diphosphate with modifications in the heterocyclic base residue were tested as substrates of rabbit muscle pyruvate kinase (ATP:pyruvate 2-O-phosphotransferase, EC. Adenosine Diphosphate 21-45 pyruvate kinase PKLR Oryctolagus cuniculus 141-156 1201504-2 1975 Mcp (1.0 muM) decreased the inhibitory effects of ATP, ADP, and adenosine on peristalsis induced in the isolated guinea-pig ileum by a constant increase in intraluminal pressure, did not affect inhibition due to theophylline ethylenediamine, whilst it potentiated inhibition of peristalsis due to noradrenaline. Adenosine Diphosphate 55-58 membrane cofactor protein Cavia porcellus 0-3 1201504-3 1975 It is proposed that this effect of Mcp may be a specific antagonistic action on receptors sensitive to the putative purinergic transmitter, ATP and ADP, and may be partly responsible for its observed facilitatatory action on peristalsis. Adenosine Diphosphate 148-151 CD46 molecule Rattus norvegicus 35-38 241335-8 1975 The complexes formed between the myosin derivatives and Sepharose-G-actin can be dissociated by low concentrations of ATP, ADP and pyrophosphate in both the presence and the absence of Mg2+. Adenosine Diphosphate 123-126 myosin heavy chain 14 Homo sapiens 33-39 1089014-10 1975 Since bidentate Cr(NH3)4ATP and monodentate CrADP also display inhibition which is tighter with time, but since bidentate CrADP is a poor inhibitor, the actural substrates in the hexokinase reaction appear to be beta, gamma-bidentate MgATP and beta-monodentate MgADP. Adenosine Diphosphate 261-266 hexokinase Saccharomyces cerevisiae S288C 179-189 5762-8 1975 ATP, ADP, and AMP inhibited ornithine decarboxylase at high concentrations (5 mM), but GTP, CTP, and ITP inhibited at a 1 mM concentration and above. Adenosine Diphosphate 5-8 ornithine decarboxylase 1 Rattus norvegicus 28-51 4414172-0 1974 Letter: Crossbridge angle when ADP is bound to myosin. Adenosine Diphosphate 31-34 myosin heavy chain 14 Homo sapiens 47-53 4364603-0 1974 Influence of human ceruloplasmin on the aggregation of human platelets by adenosine diphosphate. Adenosine Diphosphate 74-95 ceruloplasmin Homo sapiens 19-32 4335788-0 1972 The difference absorption spectrum of myosin induced by adenosine triphosphate, adenosine diphosphate, and inorganic pyrophosphate. Adenosine Diphosphate 80-101 myosin heavy chain 14 Homo sapiens 38-44 34041517-4 2021 The 50% inhibitory concentration (IC50) of G-Rb2 and G-Rd2 against ADP-induced platelet aggregation was 85.5 +- 4.5 mug mL-1 and 51.4 +- 4.6 mug mL-1, respectively. Adenosine Diphosphate 67-70 L1 cell adhesion molecule Mus musculus 120-140 33460629-1 2021 CD39 and CD73 control cell immunity by hydrolyzing proinflammatory ATP and ADP (CD39) into AMP, subsequently converted into anti-inflammatory adenosine (CD73). Adenosine Diphosphate 75-78 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 0-4 33460629-1 2021 CD39 and CD73 control cell immunity by hydrolyzing proinflammatory ATP and ADP (CD39) into AMP, subsequently converted into anti-inflammatory adenosine (CD73). Adenosine Diphosphate 75-78 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 80-84 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 selectin P Homo sapiens 64-74 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 selectin P Homo sapiens 134-144 33636040-8 2021 Additionally, the mean fluorescence intensity of ADP-stimulated P-selectin and PECAM-1 expressing platelets were reduced in bleeders (P-selectin: 944+-84U; PECAM-1: 6,722+-419U) compared to non-bleeders (P-selectin: 1,269+-130U,p=0.04; PECAM-1: 8,542+-665U,p=0.03). Adenosine Diphosphate 49-52 selectin P Homo sapiens 134-144 33925516-1 2021 Recently, we found that the expressions of adenosine (ADO) receptors A2AR and A2BR and the ectonucleotidase CD73 which is needed for the conversion of adenosine triphosphate (ATP) to adenosine diphosphate (ADP) and the extracellular ADO level are increased in TNBC MDA-MB-231 cells and RT-R-MDA-MB-231 cells compared to normal cells or non-TNBC cells. Adenosine Diphosphate 206-209 adenosine A2a receptor Homo sapiens 69-73 33986729-7 2021 In the primary hepatocytes, ADP activated the cAMP/PKA/CREB signaling pathway, which was blocked by the antagonist (2211) of the ADP receptor P2Y13. Adenosine Diphosphate 28-31 purinergic receptor P2Y, G-protein coupled 13 Mus musculus 142-147 33894202-10 2021 Our collective data provide novel insights into the different roles of these metal ions and the basis of metal selectivity of ARH3, and contribute to understanding the dynamic regulation of cellular ADP-ribosylations during the DNA damage response. Adenosine Diphosphate 199-202 ADP-ribosylserine hydrolase Homo sapiens 126-130 33848530-5 2021 We found increased ENTPD1 expression on T cells within cSCCs when compared to T cells from blood or non-lesional skin and accordingly, concentrations of derivative extracellular ADP, AMP, and adenosine are increased in tumors compared to normal skin. Adenosine Diphosphate 178-181 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 19-25 33553158-2 2020 Regulatory/effector cell balance is governed by the CD39 ectonucleotidase, the prototype member of the NTPDase family that hydrolyzes ATP and ADP into AMP, subsequently converted into adenosine by CD73. Adenosine Diphosphate 142-145 ectonucleoside triphosphate diphosphohydrolase 1 Homo sapiens 52-56 33641653-9 2021 We also confirmed that ADP upregulates GATA factors in normal clones. Adenosine Diphosphate 23-26 glutaminyl-tRNA amidotransferase subunit QRSL1 Homo sapiens 39-43 33641653-11 2021 ADP promotes erythropoiesis in myelodysplastic syndromes via downregulation of HIF1A and upregulation of GATA factors. Adenosine Diphosphate 0-3 glutaminyl-tRNA amidotransferase subunit QRSL1 Homo sapiens 105-109 32478420-7 2021 Marker-specific hyporesponsiveness of platelets to agonist [adenosine diphosphate (ADP), thrombin receptor-activating peptide 6] stimulation in vitro was observed, with significantly reduced surface levels of P-selectin in response to ADP in patients with MGUS. Adenosine Diphosphate 235-238 selectin P Homo sapiens 209-219 31949019-6 2021 The differential effect of Btk inhibition in CLEC-2 relative to GPVI signalling is explained by the positive feedback role involving Btk itself, as well as ADP and thromboxane A2 mediated activation of P2Y12 and TP receptors, respectively. Adenosine Diphosphate 156-159 glycoprotein VI platelet Homo sapiens 64-68 33386804-5 2021 OBJECTIVE: We explore the possibility that, beside the phosphatase action on phosphorylated tau, the catalytic subunit of PKA catalyzes both tau phosphorylation and also tau dephosphorylation, depending on the ATP/ADP ratio. Adenosine Diphosphate 214-217 microtubule associated protein tau Homo sapiens 92-95 33307675-1 2020 ADP-mediated platelet aggregation is signaled through G protein-coupled receptors P2Y1 and P2Y12 on the platelet. Adenosine Diphosphate 0-3 purinergic receptor P2Y12 Rattus norvegicus 91-96 32717630-12 2020 The hemostatic mechanism may involve activation of the P2Y1, P2Y12, and PKC receptors in the adenosine diphosphate (ADP) receptor signaling pathway. Adenosine Diphosphate 116-119 purinergic receptor P2Y12 Rattus norvegicus 61-66 32929610-3 2021 Alpha and beta isoforms exhibit different kinetics, ADP dissociates slower from actomyosin containing beta myosin isoform, therefore, beta myosin stays strongly bound to actin longer. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 84-90 32929610-3 2021 Alpha and beta isoforms exhibit different kinetics, ADP dissociates slower from actomyosin containing beta myosin isoform, therefore, beta myosin stays strongly bound to actin longer. Adenosine Diphosphate 52-55 myosin heavy chain 14 Homo sapiens 107-113 32929610-6 2021 All myosin constructs exhibited a fast rate of ATP binding to actomyosin and a slow rate of ADP dissociation, showing that ADP release limits the time of the strongly bound state of actomyosin. Adenosine Diphosphate 92-95 myosin heavy chain 14 Homo sapiens 4-10 32929610-6 2021 All myosin constructs exhibited a fast rate of ATP binding to actomyosin and a slow rate of ADP dissociation, showing that ADP release limits the time of the strongly bound state of actomyosin. Adenosine Diphosphate 123-126 myosin heavy chain 14 Homo sapiens 4-10 32065000-1 2020 We assessed the contribution of CYP2C19 and CYP3A4 metabolic activity to the ADP-induced platelet aggregation 1h and 24h after a loading dose of 60 mg prasugrel or 180 mg ticagrelor in patients with ST-elevations myocardial infarction (STEMI). Adenosine Diphosphate 77-80 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 32-39 32733440-1 2020 Intracellular adenosine monophosphate (AMP) is indispensable for cellular metabolic processes, and it is interconverted to ADP and/or ATP or activates AMP-activated protein kinase (AMPK). Adenosine Diphosphate 123-126 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 151-179 32044806-5 2020 In the setting of advanced disease, predictive biomarkers, such as the presence of DNA repair deficiency mediated by BRCA2 loss or mismatch repair gene defects, may suggest the utility of poly-ADP ribosylase inhibition or immune checkpoint blockade. Adenosine Diphosphate 188-196 BRCA2 DNA repair associated Homo sapiens 117-122 32443188-4 2020 Two genes encoding mitochondrial proteins identified through the QTL analysis were HFA1, a gene that encodes a mitochondrial acetyl CoA carboxylase, and AAC3, which encodes a mitochondrial inner membrane ATP/ADP translocator. Adenosine Diphosphate 208-211 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 153-157 32391487-5 2020 In addition, the phosphorylation of glucose was conducted by utilizing ADP-dependent glucokinase coupled with the ADP regeneration system, in which the hybrid nanoflower was used for regenerating ADP from AMP. Adenosine Diphosphate 71-74 glucokinase Homo sapiens 85-96 32326617-6 2020 Importantly, P2Y14 inhibition augmented Ca2+ signalling in response to ATP, ADP and mechanical stimulation. Adenosine Diphosphate 76-79 purinergic receptor P2Y, G-protein coupled, 14 Mus musculus 13-18 31932421-5 2020 Here we report that both BRCA1 poly-ADP ribosylation (PARsylation) and the presence of BRCA1-bound RAP80 are critical for the normal interaction of BRCA1 with some of its partners (e.g., CtIP and BACH1) that are also known components of the aforementioned focal structures. Adenosine Diphosphate 31-39 BRCA1 DNA repair associated Homo sapiens 25-30 31046542-6 2020 When evaluated by LTA, teriflunomide (the active metabolite of leflunomide), tocilizumab, and prednisolone reduced ADP- and collagen-induced platelet aggregation >=20%, while adalimumab increased TRAP-induced platelet aggregation >=20%. Adenosine Diphosphate 115-118 TRAP Homo sapiens 196-200 33738455-5 2020 We postulate that, when bound to ATP, Hsp70 is in equilibrium between a restraining state (R) that restricts ATP hydrolysis and binds peptides poorly, if at all, and a stimulating state (S) that hydrolyzes ATP relatively rapidly and has high intrinsic substrate affinity but rapid binding kinetics; after the hydrolysis to ADP, NBD and SBD disengage into an uncoupled state (U) that binds peptide substrates tightly, but now with slow kinetics of exchange. Adenosine Diphosphate 323-326 heat shock protein family A (Hsp70) member 4 Homo sapiens 38-43 31881809-6 2019 ADP, convulxin, and EB upregulated Syk S297 phosphorylation, which was inhibited by iloprost (cAMP pathway). Adenosine Diphosphate 0-3 spleen associated tyrosine kinase Homo sapiens 35-38 31804531-5 2019 Pharmacological elevation of cAMP using forskolin and IBMX prior to IVM decreased oocyte ATP and ATP:ADP ratio, and promoted activity of the energy regulator AMPK. Adenosine Diphosphate 101-104 cathelicidin antimicrobial peptide Mus musculus 29-33 32130599-3 2019 We showed that the XRCC1 oxidation reduces the efficiency of its ADP-ribosylation and the protein affinity for poly(ADP-ribose). Adenosine Diphosphate 65-68 X-ray repair cross complementing 1 Homo sapiens 19-24 31400387-2 2019 The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 2 Homo sapiens 132-137 31400387-2 2019 The implications of these findings for human biology are unclear as humans have two GDH-specific enzymes: hGDH1 (GLUD1-encoded) and hGDH2 (GLUD2-encoded), a novel enzyme that is highly activated by ADP and L-leucine. Adenosine Diphosphate 198-201 glutamate dehydrogenase 2 Homo sapiens 139-144 31400387-11 2019 However, L-leucine had little effect on the high insulin levels of the Tg mice, suggesting that, under the high ADP levels that prevail in beta-cells in the fasting state, glutamate flux through hGDH2 is close to maximal. Adenosine Diphosphate 112-115 glutamate dehydrogenase 2 Homo sapiens 195-200 31727786-5 2019 The ADP-ribosylation activity of AvrRpm1 is required for subsequent phosphorylation on Thr-166 of AtRIN4, an event that is necessary and sufficient for RPM1 activation. Adenosine Diphosphate 4-7 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 152-156 31492851-3 2019 Studying vesicle formation by the Coat Protein I (COPI) complex, we elucidate that NADH generated by ALDH7A1 targets Brefeldin-A ADP-Ribosylated Substrate (BARS) to inhibit COPI vesicle fission. Adenosine Diphosphate 129-132 aldehyde dehydrogenase 7 family member A1 Homo sapiens 101-108 31262040-0 2019 Influence of ABO Locus on PFA-100 Collagen-ADP Closure Time Is Not Totally Dependent on the Von Willebrand Factor. Adenosine Diphosphate 43-46 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 13-16 31108847-5 2019 In this study, we investigated whether secretion of the IL-22BP isoforms could be modulated by pharmacological targeting of GRP94 and cyclophilin B, either by means of geldanamycin, that binds to the ADP/ATP pocket shared by HSP90 paralogs, or by cyclosporin A, which causes depletion of ER cyclophilin B levels through secretion. Adenosine Diphosphate 200-203 interleukin 22 receptor subunit alpha 2 Homo sapiens 56-63 31000599-4 2019 Here, we report the crystal structure of the nsP2h bound to the conserved 3"-end 14 nucleotides of the CHIKV genome and the nonhydrolyzable transition-state nucleotide analog ADP-AlF4 Overall, the structural analysis revealed that nsP2h adopts a uniquely folded N-terminal domain followed by a superfamily 1 RNA helicase fold. Adenosine Diphosphate 175-178 DEAH-box helicase 16 Homo sapiens 308-320 30787103-0 2019 The endoplasmic reticulum (ER) chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation. Adenosine Diphosphate 97-100 heat shock protein 90 beta family member 1 Homo sapiens 50-55 30787103-7 2019 Importantly, the direct interaction between BiP and Grp94 is nucleotide-specific, with BiP and Grp94 having higher affinity under ADP conditions and lower affinity under ATP conditions. Adenosine Diphosphate 130-133 heat shock protein 90 beta family member 1 Homo sapiens 52-57 30787103-7 2019 Importantly, the direct interaction between BiP and Grp94 is nucleotide-specific, with BiP and Grp94 having higher affinity under ADP conditions and lower affinity under ATP conditions. Adenosine Diphosphate 130-133 heat shock protein 90 beta family member 1 Homo sapiens 95-100 30787103-9 2019 When BiP is in the ATP conformation its substrate-binding domain blocks Grp94; in contrast, Grp94 can readily associate with the ADP conformation of BiP, which represents the client-bound state of BiP. Adenosine Diphosphate 129-132 heat shock protein 90 beta family member 1 Homo sapiens 92-97 30984758-6 2019 These recent studies have defined how thrombin and ADP can induce Src dependent activation of the E3 ubiquitin ligase NEDD4-2. Adenosine Diphosphate 51-54 NEDD4 like E3 ubiquitin protein ligase Homo sapiens 118-125 30899048-1 2019 NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2. Adenosine Diphosphate 162-165 transient receptor potential cation channel subfamily M member 2 Homo sapiens 142-148 30899048-1 2019 NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2. Adenosine Diphosphate 162-165 transient receptor potential cation channel subfamily M member 2 Homo sapiens 212-218 30899048-1 2019 NvTRPM2 (Nematostella vectensis Transient Receptor Potential Melastatin 2), the species variant of the human apoptosis-related cation channel hTRPM2, is gated by ADP-ribose (ADPR) independently of the C-terminal NUDT9H domain that mediates ADPR-directed gating in hTRPM2. Adenosine Diphosphate 162-165 transient receptor potential cation channel subfamily M member 2 Homo sapiens 264-270 30098132-12 2019 ADP-induced IPA effect was lower with the presence of CYP2C19*2, *3 and paraoxonase (PON)1 Q192R loss-of-function (LOF) alleles, respectively (P < 0.05). Adenosine Diphosphate 0-3 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 54-61 30052109-9 2019 The expression of platelet glycoproteins, such as GP IIb/IIIa and P-selectin, native or after stimulation with ADP, were markedly impaired by the conventional system, but not by the TCSS. Adenosine Diphosphate 111-114 integrin subunit alpha 2b Homo sapiens 50-56 30359790-11 2018 CONCLUSION: Therefore, our results show that TNF-alpha negatively modulates ADP-induced aggregation via TNFR1/TNFR2 receptors by reducing cytosolic Ca++ levels and by inhibiting c-Src and fibrinogen receptor activation, which take place through cAMP- and cGMP-independent mechanisms. Adenosine Diphosphate 76-79 TNF receptor superfamily member 1A Rattus norvegicus 104-109 30359790-11 2018 CONCLUSION: Therefore, our results show that TNF-alpha negatively modulates ADP-induced aggregation via TNFR1/TNFR2 receptors by reducing cytosolic Ca++ levels and by inhibiting c-Src and fibrinogen receptor activation, which take place through cAMP- and cGMP-independent mechanisms. Adenosine Diphosphate 76-79 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 178-183 29799301-3 2018 Upon platelet activation by adenosine diphosphate (ADP), thrombin, or other platelet agonists, GPIIb-IIIa undergoes conformational changes from a "resting" bent conformation to an "activated" extended conformation. Adenosine Diphosphate 28-49 integrin subunit alpha 2b Homo sapiens 95-100 29799301-3 2018 Upon platelet activation by adenosine diphosphate (ADP), thrombin, or other platelet agonists, GPIIb-IIIa undergoes conformational changes from a "resting" bent conformation to an "activated" extended conformation. Adenosine Diphosphate 51-54 integrin subunit alpha 2b Homo sapiens 95-100 30205291-5 2018 In this study, two homology models of GRP170 were constructed based on the X-ray crystal structures of ADP and ATP bound HSP110, a cytosolic homolog of GRP170, in order to characterize the differences in the binding modes of both ligands. Adenosine Diphosphate 103-106 hypoxia up-regulated 1 Homo sapiens 38-44 29459768-2 2018 X-ray or laser irradiation could evoke the accumulation of Tudor-SN to DNA damage sites in a poly(ADP-ribosyl)ation-dependent manner via interaction with PARP-1. Adenosine Diphosphate 97-101 staphylococcal nuclease and tudor domain containing 1 Homo sapiens 59-67 29648519-7 2018 The combined model (GK-GDH-core) shows that GK activity determines the energy state ([ATP]/[ADP][Pi]) in beta-cells for glucose concentrations > 5 mM ([ADP] < 35 microM). Adenosine Diphosphate 92-95 glucokinase Homo sapiens 20-22 29648519-7 2018 The combined model (GK-GDH-core) shows that GK activity determines the energy state ([ATP]/[ADP][Pi]) in beta-cells for glucose concentrations > 5 mM ([ADP] < 35 microM). Adenosine Diphosphate 92-95 glucokinase Homo sapiens 44-46 29648519-7 2018 The combined model (GK-GDH-core) shows that GK activity determines the energy state ([ATP]/[ADP][Pi]) in beta-cells for glucose concentrations > 5 mM ([ADP] < 35 microM). Adenosine Diphosphate 155-158 glucokinase Homo sapiens 20-22 29648519-7 2018 The combined model (GK-GDH-core) shows that GK activity determines the energy state ([ATP]/[ADP][Pi]) in beta-cells for glucose concentrations > 5 mM ([ADP] < 35 microM). Adenosine Diphosphate 155-158 glucokinase Homo sapiens 44-46 29782832-7 2018 Furthermore, Nup159 did not accelerate ADP release, while Gle1 actually slowed ADP release independent of Mg2+. Adenosine Diphosphate 79-82 GLE1 RNA export mediator Homo sapiens 58-62 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 GLE1 RNA export mediator Homo sapiens 60-64 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 GLE1 RNA export mediator Homo sapiens 160-164 29782832-9 2018 Instead, in the presence of Nup159, the interaction between Gle1 and ADP-bound Dbp5 was found to be reduced by ~18-fold, suggesting that Nup159 alters the Dbp5-Gle1 interaction to aid Gle1 release from Dbp5. Adenosine Diphosphate 69-72 GLE1 RNA export mediator Homo sapiens 160-164 29407631-5 2018 RESULTS: Genetic mutations in rs822441, rs822442, and CYP2C19*2/*3 alleles were significantly associated with a decrease in PIR induced by adenosine diphosphate (ADP). Adenosine Diphosphate 139-160 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 54-61 29407631-5 2018 RESULTS: Genetic mutations in rs822441, rs822442, and CYP2C19*2/*3 alleles were significantly associated with a decrease in PIR induced by adenosine diphosphate (ADP). Adenosine Diphosphate 162-165 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 54-61 30112992-2 2018 PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post-translationally. Adenosine Diphosphate 38-41 poly(ADP-ribose) polymerase family member 14 Homo sapiens 0-6 29056231-3 2017 It has been recently proposed that the binding specificity of the yeast mitochondrial ADP/ATP carrier (yAAC3) toward cardiolipins is preserved in DPC, thereby suggesting that DPC is a suitable environment in which to study membrane proteins. Adenosine Diphosphate 86-89 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 103-108 29059240-1 2017 We studied the interaction between GroES and a single-ring mutant (SR1) of GroEL by the NMR titration of 15N-labeled GroES with SR1 at three different temperatures (20, 25 and 30 C) in the presence of 3 mM ADP in 100 mM KCl and 10 mM MgCl2 at pH 7.5. Adenosine Diphosphate 206-209 heat shock protein family D (Hsp60) member 1 Homo sapiens 75-80 28736132-3 2017 High on-treatment platelet reactivity (HTPR) to ADP was assessed by TEG-ADPMA and detected the CYP2C19 genotype; recurrent ischemic events were followed up for 90 days after onset. Adenosine Diphosphate 48-51 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 95-102 28963484-1 2017 ADP-ribosylhydrolases (ARH1, ARH2 and ARH3) are a family of enzymes to catalyze ADP-ribosylation, a reversible and covalent post-translational modification (PTM). Adenosine Diphosphate 0-3 ADP-ribosylarginine hydrolase Homo sapiens 23-27 28963484-1 2017 ADP-ribosylhydrolases (ARH1, ARH2 and ARH3) are a family of enzymes to catalyze ADP-ribosylation, a reversible and covalent post-translational modification (PTM). Adenosine Diphosphate 0-3 ADP-ribosylhydrolase like 1 Homo sapiens 29-33 28963484-5 2017 All these changes facilitate ADP-RA to bind ARH1. Adenosine Diphosphate 29-32 ADP-ribosylarginine hydrolase Homo sapiens 44-48 28894003-3 2017 We show that the energy of the power stroke and the barriers involved in it are of minor consequence to the selectivity of forward over backward steps and instead suggest that the selective release of ADP from a postrigor myosin motor head promotes highly selective and processive myosin V. Adenosine Diphosphate 201-204 myosin VA Homo sapiens 281-289 28409324-1 2017 Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) is an ectonucleotidase that modulates P2 receptor activation by hydrolyzing ATP to ADP. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 0-44 28409324-1 2017 Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) is an ectonucleotidase that modulates P2 receptor activation by hydrolyzing ATP to ADP. Adenosine Diphosphate 139-142 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 46-54 28647477-3 2017 We found that TPP+C10 increased the cytosolic ADP/ATP ratio and significantly increased the AMP levels in a concentration-dependent manner in TA3/Ha murine mammary adenocarcinoma cells. Adenosine Diphosphate 46-49 gene rich cluster, C10 gene Mus musculus 18-21 28824383-1 2017 Poly (ADP-ribose) polymerases (PARPs) are enzymes that catalyze ADP-ribose units transfer from NAD to their substrate proteins. Adenosine Diphosphate 6-9 poly (ADP-ribose) polymerase family, member 1 Mus musculus 31-36 28414123-6 2017 ZGR also inhibited ADP- and U46619- induced phosphorylation of myristolated alanine-rich C-kinase substrate (MARCKS) and the expressions of P-selectin and PAC-1 in platelets. Adenosine Diphosphate 19-22 myristoylated alanine rich protein kinase C substrate Mus musculus 109-115 28300864-11 2017 We also observed suggestive associations of AR (p = 7.39x10-6) and MAPRE1 (p = 7.26x10-6) with ADP-induced reactivity. Adenosine Diphosphate 95-98 microtubule associated protein RP/EB family member 1 Homo sapiens 67-73 28092426-8 2017 Methods Whole blood was treated in vitro with ~ 50% inhibitory concentrations of ticagrelor, T-AM, cangrelor, P-AM and assessed for ADP-stimulated activated GPIIb-IIIa and P-selectin and vasodilator-stimulated phosphoprotein (VASP) platelet reactivity index (PRI) before and after 100-fold dilution. Adenosine Diphosphate 132-135 integrin subunit alpha 2b Homo sapiens 157-162 27699616-0 2017 Backbone and methyl resonance assignments of the 42 kDa human Hsc70 nucleotide binding domain in the ADP state. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 8 Homo sapiens 62-67 27929199-5 2017 Gremlin-1 release upon activation with ADP, CRP, and TRAP was detected as enhanced surface expression; also in activated platelet supernatant as detected by Western Blot following CRP activation and by ELISA upon activation with ADP, CRP, PAR-1, and PAR4 agonist. Adenosine Diphosphate 229-232 TRAP Homo sapiens 53-57 27929199-6 2017 Recombinant (rh)Gremlin-1 synergistically enhanced CRP-triggered intracellular calcium mobilisation, ADP-TRAP induced platelet activation, aggregation, and thrombin-activation triggered apoptosis; also thrombus formation ex vivo. Adenosine Diphosphate 101-104 TRAP Homo sapiens 105-109 27858225-4 2017 Putative models for HSP70 complexation to the receptor for advanced glycation endproducts (RAGEs), considering both ADP- and ATP-bound states of HSP70, were obtained through molecular docking and interaction energy calculations. Adenosine Diphosphate 116-119 heat shock protein family A (Hsp70) member 4 Homo sapiens 20-25 27525577-4 2016 Results indicated that Abcc3 KO mice exhibited increased formation of CAM and greater systemic exposure to clopidogrel and enhanced inhibition of adenosine diphosphate-induced platelet aggregation ex vivo by clopidogrel when compared with well-matched WT mice. Adenosine Diphosphate 146-167 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Mus musculus 23-28 27687724-8 2016 Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP. Adenosine Diphosphate 129-132 sphingomyelin phosphodiesterase, acid-like 3B Mus musculus 35-42 27766054-12 2016 In murine platelets, p59 is the only Dab2 isoform and is required for platelet aggregation, fibrinogen uptake, RhoA-ROCK activation, adenosine diphosphate release and integrin alphaIIbbeta3 activation stimulated by low concentration of thrombin. Adenosine Diphosphate 133-154 spermatogenesis associated, serine-rich 2 Mus musculus 21-24 27422820-0 2016 Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein alphaIIbbeta3 Activation through Dysregulation of the 5-HT2A Receptor. Adenosine Diphosphate 46-49 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 126-141 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 46-67 poly (ADP-ribose) polymerase family, member 1 Mus musculus 118-147 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 46-67 poly (ADP-ribose) polymerase family, member 1 Mus musculus 149-154 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 69-72 poly (ADP-ribose) polymerase family, member 1 Mus musculus 118-147 27635653-1 2016 The rapid and robust synthesis of polymers of adenosine diphosphate (ADP)-ribose (PAR) chains, primarily catalyzed by poly(ADP-ribose) polymerase 1 (PARP1), is crucial for cellular responses to DNA damage. Adenosine Diphosphate 69-72 poly (ADP-ribose) polymerase family, member 1 Mus musculus 149-154 27417582-2 2016 CD39 hydrolyzes extracellular ATP or ADP to AMP. Adenosine Diphosphate 37-40 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 27173608-4 2016 ADP, one of the cycling reaction products, was distinguished from IDP by using the nucleotide selectivity of the ADP-GK. Adenosine Diphosphate 0-3 ADP dependent glucokinase Homo sapiens 113-119 26837379-7 2016 Relative ADP induced aggregation (r-ADP-agg) was defined as the ADP-TRAP-ratio to reflect an individual degree of P2Y12-dependent platelet inhibition. Adenosine Diphosphate 9-12 TRAP Homo sapiens 68-72 26946085-9 2016 By contrast, mMDH activity was lowered by adenine nucleotides (AMP, ADP, and ATP). Adenosine Diphosphate 68-71 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 13-17 26946085-11 2016 Correspondingly, mMDH activity was inhibited by the increase in ATP/ADP ratio within the physiological range. Adenosine Diphosphate 68-71 malate dehydrogenase 2, NAD (mitochondrial) Mus musculus 17-21 27158649-2 2016 We report the coordinates of the ADP/ATP carrier (AAC2) in the presence and absence of adenine and guanine nucleotides in the c-, intermediate- and m-states obtained from the free-energy simulations and corresponding to the free-energy minima. Adenosine Diphosphate 33-36 solute carrier family 25 member 5 Homo sapiens 50-54 27043630-1 2016 Clostridium botulinum exoenzyme C3 is the prototype of C3-like ADP-ribosyltransferases that modify the GTPases RhoA, B, and C. C3 catalyzes the transfer of an ADP-ribose moiety from the co-substrate nicotinamide adenine dinucleotide (NAD) to asparagine-41 of Rho-GTPases. Adenosine Diphosphate 63-66 transforming protein RhoA Cricetulus griseus 111-115 27043630-4 2016 Since this gel-shift assay does not always provide clear, evaluable results an additional method to confirm the ADP-ribosylation of RhoA is necessary. Adenosine Diphosphate 112-115 transforming protein RhoA Cricetulus griseus 132-136 27043630-5 2016 Therefore, a new monoclonal antibody has been generated that specifically detects ADP-ribosylated RhoA/B, but not RhoC, in Western blot and immunohistochemical assay. Adenosine Diphosphate 82-85 transforming protein RhoA Cricetulus griseus 98-104 27043630-8 2016 We demonstrate that this specific antibody can be successfully applied for the analysis of ADP-ribosylated RhoA/B in C3-treated Chinese hamster ovary (CHO) and HT22 cells. Adenosine Diphosphate 91-94 transforming protein RhoA Cricetulus griseus 107-113 27043630-9 2016 Moreover, ADP-ribosylation of RhoA was detected within 10 min in C3-treated CHO wild-type cells, indicative of C3 cell entry. Adenosine Diphosphate 10-13 transforming protein RhoA Cricetulus griseus 30-34 26069241-11 2016 There were significant decreases in vasodilatory response to endothelial-dependent vasodilator ADP after CP/CPB (P < 0.05). Adenosine Diphosphate 95-98 carboxypeptidase B1 Homo sapiens 105-111 26885820-0 2016 The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y12-Dependent Platelet Inhibition Independently of the Platelet Count. Adenosine Diphosphate 13-16 TRAP Homo sapiens 21-25 26885820-5 2016 Relative ADP-induced aggregation (r-ADP-agg) was defined as the ratio of ADP- to TRAP- induced aggregation reflecting the individual degree of P2Y12-mediated platelet reactivity. Adenosine Diphosphate 9-12 TRAP Homo sapiens 81-85 26885820-5 2016 Relative ADP-induced aggregation (r-ADP-agg) was defined as the ratio of ADP- to TRAP- induced aggregation reflecting the individual degree of P2Y12-mediated platelet reactivity. Adenosine Diphosphate 36-39 TRAP Homo sapiens 81-85 26885820-8 2016 While ADP- and TRAP-induced platelet aggregation correlated significantly with platelet count (ADP: r = 0.302; p<0.001; TRAP: r = 0.509 p<0.001), r-ADP-agg values did not (r = -0.003; p = 0.960). Adenosine Diphosphate 6-9 TRAP Homo sapiens 123-127 26885820-8 2016 While ADP- and TRAP-induced platelet aggregation correlated significantly with platelet count (ADP: r = 0.302; p<0.001; TRAP: r = 0.509 p<0.001), r-ADP-agg values did not (r = -0.003; p = 0.960). Adenosine Diphosphate 95-98 TRAP Homo sapiens 15-19 26333425-8 2016 P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5"-diphosphate (UDP)] have been shown to have profibrotic effects, as well. Adenosine Diphosphate 25-28 purinergic receptor P2Y2 Homo sapiens 0-4 26713879-8 2015 In vitro transcribed/translated human beta-actin confirmed the crucial role of Glu270 in ADP-ribosylation of actin by Ia. Adenosine Diphosphate 89-92 POTE ankyrin domain family member F Homo sapiens 38-48 26682803-3 2015 KATP channels are inhibited by ATP (or ADP) binding to Kir6.2 and activated by Mg-nucleotide interactions with SUR. Adenosine Diphosphate 39-42 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 55-61 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 17-22 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 118-123 26160282-7 2015 The reduction of GPIIb/IIIa on the platelet surface was further proved by the reduction of further activated platelet GPIIb/IIIa surface expression induced by ADP and the increase in GPIIb/IIIa concentration in microparticle-free plasma with increasing the applied shear stress and exposure time. Adenosine Diphosphate 159-162 integrin subunit alpha 2b Homo sapiens 118-123 26014752-6 2015 Patients with concomitant CCB therapy showed significantly higher platelet surface expressions of P-selectin and activated GPIIb/IIIa in response to ADP than patients without CCBs (both P <= 0.03). Adenosine Diphosphate 149-152 integrin subunit alpha 2b Homo sapiens 123-128 26014752-7 2015 Moreover, the fold increase of P-selectin and activated GPIIb/IIIa in response to ADP was significantly more pronounced in patients taking CCBs (both P <= 0.03). Adenosine Diphosphate 82-85 integrin subunit alpha 2b Homo sapiens 56-61 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 20-23 integrin subunit alpha 2b Homo sapiens 44-49 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 20-23 integrin subunit alpha 2b Homo sapiens 86-91 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 119-122 integrin subunit alpha 2b Homo sapiens 44-49 26014752-8 2015 The associations of ADP-inducible activated GPIIb/IIIa and fold increase of activated GPIIb/IIIa after the addition of ADP with CCB therapy remained significant after adjustment for differences in patient characteristics and factors that were previously associated with clopidogrel response by multivariate regression analyses (both P < 0.05). Adenosine Diphosphate 119-122 integrin subunit alpha 2b Homo sapiens 86-91 26008223-4 2015 Ectonucleotidases and adenosine deaminase (ADA) are enzymes responsible for the hydrolysis of ATP (and other nucleotides such as ADP, UTP, UDP, AMP) and adenosine, respectively. Adenosine Diphosphate 129-132 adenosine deaminase Homo sapiens 22-41 26008223-4 2015 Ectonucleotidases and adenosine deaminase (ADA) are enzymes responsible for the hydrolysis of ATP (and other nucleotides such as ADP, UTP, UDP, AMP) and adenosine, respectively. Adenosine Diphosphate 129-132 adenosine deaminase Homo sapiens 43-46 26121751-2 2015 The enzyme ectonucleotide tri(di)phosphohydrolase-1 (ENTPD1, also known as CD39) on the surface of leukocytes and endothelial cells metabolizes locally released, intravascular ATP and ADP, thereby eliminating these prothrombotic and proinflammatory stimuli. Adenosine Diphosphate 184-187 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 75-79 25985179-6 2015 Here we report the first structures of the mammalian PFK1 tetramer, for the human platelet isoform (PFKP), in complex with ATP-Mg(2+) and ADP at 3.1 and 3.4 A, respectively. Adenosine Diphosphate 138-141 phosphofructokinase, platelet Homo sapiens 100-104 26042225-3 2015 Release of clathrin in association with Hsc70(*)ADP follows, and the subsequent, persistent association of clathrin with Hsc70 is important to prevent aberrant clathrin polymerization. Adenosine Diphosphate 48-51 heat shock protein family A (Hsp70) member 8 Homo sapiens 40-45 25777528-5 2015 KIF5C acquires the "rigor conformation", where mobile switches I and II are stabilized through L11 and the initial portion of the neck-linker, facilitating effective ADP release and the weak-to-strong transition of KIF5C microtubule affinity. Adenosine Diphosphate 166-169 immunoglobulin kappa variable 1-6 Homo sapiens 95-98 25594796-6 2015 ADP-specific assays (VASP PRI) differed according to CYP2C19 genotype, with a significant gene-dose effect (PMs > IMs > EMs, p < 0.05). Adenosine Diphosphate 0-3 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 53-60 25654640-2 2015 Controlled by its ATPase activity, Hsp70 cycles between two conformations, Hsp70-ATP and Hsp70-ADP, to bind and release its substrate. Adenosine Diphosphate 95-98 heat shock protein family A (Hsp70) member 4 Homo sapiens 35-40 25654640-2 2015 Controlled by its ATPase activity, Hsp70 cycles between two conformations, Hsp70-ATP and Hsp70-ADP, to bind and release its substrate. Adenosine Diphosphate 95-98 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 25654640-2 2015 Controlled by its ATPase activity, Hsp70 cycles between two conformations, Hsp70-ATP and Hsp70-ADP, to bind and release its substrate. Adenosine Diphosphate 95-98 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 25593336-4 2015 HPS6(-/-) platelets displayed impaired PDI secretion and impaired exocytosis of alpha granules, lysosomes, and T granules due to decreased sensitivity to thrombin, but these defects could be corrected by addition of subthreshold amounts of adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 240-264 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Mus musculus 0-4 25593336-4 2015 HPS6(-/-) platelets displayed impaired PDI secretion and impaired exocytosis of alpha granules, lysosomes, and T granules due to decreased sensitivity to thrombin, but these defects could be corrected by addition of subthreshold amounts of adenosine 5"-diphosphate (ADP). Adenosine Diphosphate 266-269 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Mus musculus 0-4 25768541-2 2015 No previous theoretical models of the myosin-V walk reproduce all the observed trends of velocity and run length with adenosine diphosphate (ADP), ATP and external forcing. Adenosine Diphosphate 118-139 myosin VA Homo sapiens 38-46 25768541-2 2015 No previous theoretical models of the myosin-V walk reproduce all the observed trends of velocity and run length with adenosine diphosphate (ADP), ATP and external forcing. Adenosine Diphosphate 141-144 myosin VA Homo sapiens 38-46 25452336-8 2015 These results uncover a new regulatory mechanism of ARTD1-induced ADP-ribosylation and highlight its importance for nuclear factor-regulated gene expression. Adenosine Diphosphate 66-69 poly (ADP-ribose) polymerase family, member 1 Mus musculus 52-57 25734215-1 2015 Galphaq plays an important role in platelet activation by agonists such as thrombin, adenosine diphosphate (ADP) and thromboxane. Adenosine Diphosphate 85-106 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 0-7 25734215-1 2015 Galphaq plays an important role in platelet activation by agonists such as thrombin, adenosine diphosphate (ADP) and thromboxane. Adenosine Diphosphate 108-111 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 0-7 25514563-10 2014 The release of platelet inflammatory mediators (IL-1beta, TGF-beta1, CCL5 and thromboxane B2) induced by ADP was inhibited by Eruca sativa Mill. Adenosine Diphosphate 105-108 C-C motif chemokine ligand 5 Homo sapiens 69-73 25208912-0 2014 Assessment of DNA binding to human Rad51 protein by using quartz crystal microbalance and atomic force microscopy: effects of ADP and BRC4-28 peptide inhibitor. Adenosine Diphosphate 126-129 RAD51 recombinase Homo sapiens 35-40 25393959-10 2014 In addition, SQ22536 (an adenylate cyclase inhibitor) and ZM241385 (a potent adenosine receptor A2A antagonist) attenuated the effect of adenosine on platelet aggregation induced by ADP and intraplatelet level of cAMP. Adenosine Diphosphate 182-185 immunoglobulin kappa variable 2D-29 Homo sapiens 96-99 25329996-3 2014 Here, we sought to determine the associations of CYP2C19 and PON1 gene polymorphisms with clopidogrel response and their role in ADP-induced platelet aggregation. Adenosine Diphosphate 129-132 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 49-56 25112874-4 2014 The caspase-activated Panx1 channels mediated efflux of ATP, but also ADP and AMP, with the latter two comprising >90% of the released adenine nucleotide pool as cells transitioned from the early to late stages of apoptosis. Adenosine Diphosphate 70-73 pannexin 1 Homo sapiens 22-27 25002576-3 2014 The enzyme is regulated by ADP and ATP, which is believed to be mediated through the ligand-induced oligomerization of the thioesterase domains, whereby ATP induces active dimers and tetramers, whereas apo- and ADP-bound ACOT12 are monomeric and inactive. Adenosine Diphosphate 27-30 acyl-CoA thioesterase 12 Homo sapiens 221-227 25002576-3 2014 The enzyme is regulated by ADP and ATP, which is believed to be mediated through the ligand-induced oligomerization of the thioesterase domains, whereby ATP induces active dimers and tetramers, whereas apo- and ADP-bound ACOT12 are monomeric and inactive. Adenosine Diphosphate 211-214 acyl-CoA thioesterase 12 Homo sapiens 221-227 24735890-7 2014 It is postulated that glucose-induced inhibition of Cx36 hemichannels in islet beta-cells might avoid depolarization-induced ATP loss, allowing an optimum increase of the ATP/ADP ratio by sugar metabolism and a biphasic stimulation of insulin secretion. Adenosine Diphosphate 175-178 gap junction protein, delta 2 Mus musculus 52-56 24642865-4 2014 The P-selectin and activated gpIIb/IIIa expression on platelet membranes in response to ADP, collagen and thrombin stimulation was measured at various hematocrit and oxygen levels. Adenosine Diphosphate 88-91 integrin subunit alpha 2b Homo sapiens 29-34 24550450-5 2014 ADP treatment promoted the H2O2-dependent phosphorylation of c-Abl, a nonreceptor tyrosine kinase that modulates the actin cytoskeleton. Adenosine Diphosphate 0-3 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 61-66 24550450-6 2014 Cellular imaging experiments using fluorescence resonance energy transfer-based biosensors revealed that ADP-stimulated activation of the cytoskeleton-associated small GTPase Rac1 was independent of H2O2. Adenosine Diphosphate 105-108 Rac family small GTPase 1 Homo sapiens 175-179 24528675-5 2014 On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT). Adenosine Diphosphate 80-83 purple acid phosphatase 10 Arabidopsis thaliana 130-137 24531484-0 2014 The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Adenosine Diphosphate 144-147 casein kinase 2 alpha 2 Homo sapiens 82-90 24531484-9 2014 This may suggest a clue to a possible ADP/GDP-release pathway, because the NE1 atom of the Trp in the `DWG motif" of CK2alpha forms a hydrogen bond to the O atom of Leu212, which seems to make ADP release by means of the `DFG-in flip to DFG-out" model found in most eukaryotic protein kinases impossible. Adenosine Diphosphate 38-41 casein kinase 2 alpha 2 Homo sapiens 117-125 24531484-9 2014 This may suggest a clue to a possible ADP/GDP-release pathway, because the NE1 atom of the Trp in the `DWG motif" of CK2alpha forms a hydrogen bond to the O atom of Leu212, which seems to make ADP release by means of the `DFG-in flip to DFG-out" model found in most eukaryotic protein kinases impossible. Adenosine Diphosphate 193-196 casein kinase 2 alpha 2 Homo sapiens 117-125 24271779-3 2014 Sucla2 encodes the ADP-specific beta-subunit isoform of SCS. Adenosine Diphosphate 19-22 succinate-Coenzyme A ligase, ADP-forming, beta subunit Mus musculus 0-6 24172891-6 2014 Relative ADP induced aggregation (r-ADP-agg) was defined as the ADP-TRAP ratio to reflect an individual degree of P2Y12-dependent platelet inhibition.Platelet function of 238 patients was analysed [clopidogrel (n=58), prasugrel (n=65), ticagrelor (n=115)]. Adenosine Diphosphate 9-12 TRAP Homo sapiens 68-72 24474793-3 2014 Here we present the structures of the yeast ADP/ATP carriers Aac2p and Aac3p in the cytoplasmic state. Adenosine Diphosphate 44-47 ADP/ATP carrier protein AAC3 Saccharomyces cerevisiae S288C 71-76 24466319-7 2014 In separate experiments, our studies revealed that these 5-HT2A receptor antagonists have the capacity to reduce serotonin-enhanced ADP-induced elevation in intracellular calcium levels and tyrosine phosphorylation. Adenosine Diphosphate 132-135 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 57-72 24454860-1 2014 Hsp70 binding protein 1 (HspBP1) and Bcl2-associated athanogene 1 (BAG-1), the functional orthologous nucleotide exchange factors of the heat shock protein 70 kilodalton (Hsc70/Hsp70) chaperones, catalyze the release of ADP from Hsp70 while inducing different conformational changes of the ATPase domain of Hsp70. Adenosine Diphosphate 220-223 heat shock protein family A (Hsp70) member 8 Homo sapiens 171-176 25518510-9 2014 Evaluation of ADP-induced platelet aggregation in patients with different CYP2C9 and CYP2C19 gene polymorphisms during the administration of original or generic clopidogrel also showed no significant differences in its resistance. Adenosine Diphosphate 14-17 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 85-92 25518511-12 2014 Examining the effects of genetic variations in cytochrome P450 isoform CYP2C19 (a clopidogrel metabolizer) revealed the enhanced aggregation stimulated with 20 mumol of ADP in the carriers of slowly clopidogrel-metabolizing haplotype of CYP2C19 (differences were found on days 3-5 as compared to rapidly and routinely metabolizing haplotypes). Adenosine Diphosphate 169-172 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 71-78 25518511-12 2014 Examining the effects of genetic variations in cytochrome P450 isoform CYP2C19 (a clopidogrel metabolizer) revealed the enhanced aggregation stimulated with 20 mumol of ADP in the carriers of slowly clopidogrel-metabolizing haplotype of CYP2C19 (differences were found on days 3-5 as compared to rapidly and routinely metabolizing haplotypes). Adenosine Diphosphate 169-172 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 237-244 24290758-2 2013 We present crystal structures of S. cerevisiae Prp5p alone and in complex with ADP at 2.12 A and 1.95 A resolution. Adenosine Diphosphate 79-82 DEAD-box RNA helicase PRP5 Saccharomyces cerevisiae S288C 47-52 24353446-6 2013 CYP2C19*2 genotype was associated with increased on-treatment platelet aggregation (adenosine diphosphate 20 muM; P=0.025). Adenosine Diphosphate 84-105 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 23939864-0 2013 Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation. Adenosine Diphosphate 83-86 SRY-box transcription factor 2 Homo sapiens 78-82 23075261-3 2013 The conformations of ADP-bound (or nucleotide-free) hHsp70 and ATP-bound hHsp70 was investigated by using unbiased all-atom molecular dynamics (MD) simulations of homology models of hHsp70 in explicit solvent on a timescale of .5 and 2.7 mus, respectively. Adenosine Diphosphate 21-24 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-58 23806217-8 2013 PKA was cosedimented with nNOS by ADP agarose gel. Adenosine Diphosphate 34-37 nitric oxide synthase 1 Rattus norvegicus 26-30 24066180-6 2013 The levels of ATP, ADP but not 5"-AMP in erythrocytes of Ampd3(-/-) mice were significantly elevated. Adenosine Diphosphate 19-22 adenosine monophosphate deaminase 3 Mus musculus 57-62 23809542-6 2013 In contrast, CYP2C19*17 was marginally associated with clopidogrel active metabolite levels and ADP-stimulated platelet aggregation before (beta = 1.57, P = 0.04 and beta = -1.98, P = 0.01, respectively) but not after (beta = 0.40, P = 0.59 and beta = -0.13, P = 0.69, respectively) adjustment for the CYP2C19*2 variant. Adenosine Diphosphate 96-99 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 13-20 23809542-6 2013 In contrast, CYP2C19*17 was marginally associated with clopidogrel active metabolite levels and ADP-stimulated platelet aggregation before (beta = 1.57, P = 0.04 and beta = -1.98, P = 0.01, respectively) but not after (beta = 0.40, P = 0.59 and beta = -0.13, P = 0.69, respectively) adjustment for the CYP2C19*2 variant. Adenosine Diphosphate 96-99 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 302-309 23818625-3 2013 The primary mode of signal perception by P(II) proteins derives from their ability to bind the effector molecules 2-oxoglutarate (2-OG) and ATP or ADP. Adenosine Diphosphate 147-150 nitrogen regulatory P-II-like protein Arabidopsis thaliana 41-46 23818625-7 2013 We propose that the role of ATP/ADP binding in E. coli GlnK is to effect a 2-OG-dependent molecular switch that drives a conformational change in the T loops of the P(II) protein. Adenosine Diphosphate 32-35 nitrogen regulatory P-II-like protein Arabidopsis thaliana 165-170 23729489-8 2013 Moreover, patients with CKD exhibited a more pronounced expression of GPIIb/IIIa in response to ADP (13 versus 9.6 MFI) and AA (6 versus 5.1 MFI; both P<= 0.02) than patients without CKD. Adenosine Diphosphate 96-99 integrin subunit alpha 2b Homo sapiens 70-75 23770670-8 2013 This report 1) identifies ADP-ribosylation as a new posttranslational modification for PEPCK, 2) describes a pathway by which transcriptional induction of TiPARP by the AHR can lead to a downstream posttranslational change in a TCDD target protein (PEPCK), and 3) reveals that the AHR exerts complex, previously unidentified modulatory effects on ADP-ribosylation. Adenosine Diphosphate 26-29 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 87-95 23770670-8 2013 This report 1) identifies ADP-ribosylation as a new posttranslational modification for PEPCK, 2) describes a pathway by which transcriptional induction of TiPARP by the AHR can lead to a downstream posttranslational change in a TCDD target protein (PEPCK), and 3) reveals that the AHR exerts complex, previously unidentified modulatory effects on ADP-ribosylation. Adenosine Diphosphate 26-29 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 87-92 23860249-1 2013 The carrier Endoplasmic Reticulum Adenylate Transporter1 (ER-ANT1) resides in the endoplasmic reticulum (ER) membrane and acts as an ATP/ADP antiporter. Adenosine Diphosphate 137-140 endoplasmic reticulum-adenine nucleotide transporter 1 Arabidopsis thaliana 12-56 23860249-1 2013 The carrier Endoplasmic Reticulum Adenylate Transporter1 (ER-ANT1) resides in the endoplasmic reticulum (ER) membrane and acts as an ATP/ADP antiporter. Adenosine Diphosphate 137-140 endoplasmic reticulum-adenine nucleotide transporter 1 Arabidopsis thaliana 58-65 23521641-2 2013 C3 transferase, an exoenzyme produced by Clostridium botulinum that inactivates RhoA by ADP-ribosylation, has been successfully applied in central nervous system (CNS) lesion models to facilitate regeneration functionally and morphologically. Adenosine Diphosphate 88-91 ras homolog family member A Rattus norvegicus 80-84 23556336-6 2013 In those patients who were carriers of 1 mutant allele (mutant heterozygotes, CYP2C19*1/*2 or *1/*3), ADP-induced maximum platelet aggregation (MPA) were significantly different compared with wild-type homozygous patients [37.2% (IQR, 19.6 to 50.5%) versus 23.6% (IQR, 14.0 to 35.4%), respectively; P=0.002]. Adenosine Diphosphate 102-105 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 78-85 23556336-8 2013 By multivariable linear regression, CYP2C19*2 or *3 loss-of-function alleles were independently associated with ADP-induced MPA measurements (partial R2 = 0.138, P = 0.001). Adenosine Diphosphate 112-115 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 36-43 23153623-5 2013 In comparison to placebo using the random-effect model, n-3 PUFA-supplementation significantly reduced adenosine diphosphate-induced platelet aggregation (standard mean difference [SMD] = -1.23 with 95% confidence interval [CI] -2.24 to -0.23, p = 0.02) and platelet aggregation units, determined using the VerifyNow( ) rapid platelet-function assay system (SMD = -6.78 with 95% CI -12.58 to -0.98, p = 0.02). Adenosine Diphosphate 103-124 pumilio RNA binding family member 3 Homo sapiens 60-64 28348696-3 2013 The purpose of this review is to define the roles that GP IIb/IIIa inhibitors may still have in acute ischemic settings by explaining why in high risk patients they might be preferable and/or whether they might be added to ADP inhibitors also emphasizing the underlying mechanistic actions. Adenosine Diphosphate 223-226 integrin subunit alpha 2b Homo sapiens 55-61 22981600-0 2012 Translocon-independent intracellular replication by Pseudomonas aeruginosa requires the ADP-ribosylation domain of ExoS. Adenosine Diphosphate 88-91 exoenzyme S Pseudomonas aeruginosa PAO1 115-119 22885372-0 2012 A study of the imbalance in B cell-expressed nucleoside triphosphate diphosphohydrolase 1-induced ADP degradation in graft injury during acute antibody-mediated rejection. Adenosine Diphosphate 98-101 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 45-89 22885372-1 2012 OBJECTIVE: To study the effects and mechanisms of the imbalance in B cell-expressed nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1)-induced ADP degradation on graft injury during acute antibody-mediated rejection (AMR). Adenosine Diphosphate 149-152 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 84-128 22885372-1 2012 OBJECTIVE: To study the effects and mechanisms of the imbalance in B cell-expressed nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1)-induced ADP degradation on graft injury during acute antibody-mediated rejection (AMR). Adenosine Diphosphate 149-152 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 130-139 22885372-10 2012 CONCLUSIONS: An imbalance in the NTPDase 1-induced degradation of extracellular ADP may be a major cause of graft injury in acute AMR. Adenosine Diphosphate 80-83 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 33-42 23427948-5 2012 Good response to KLP treatment with 20 micromol/l ADP-induced platelet aggregation inhibition < 60% reached 66.1% of patients, partial response with 60-70% inhibition 13.9% of patients and poor response > 70% in 20% of patients. Adenosine Diphosphate 50-53 kinesin family member 1B Homo sapiens 17-20 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Diphosphate 22-43 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 105-153 22540145-3 2012 Extracellular ATP and adenosine diphosphate are converted to adenosine monophosphate (AMP) by the enzyme ectonucleoside triphosphate diphosphohydrolase 1, also known as CD39, and extracellular AMP is in turn converted to adenosine by the 5"-ectonuleotidase enzyme CD73. Adenosine Diphosphate 22-43 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 169-173 22399070-4 2012 We predict that Escherichia coli YbiA and related families of domains from diverse bacteria, eukaryotes, large DNA viruses and single strand RNA viruses are previously unrecognized components of NAD-utilizing pathways that probably operate on ADP-ribose derivatives. Adenosine Diphosphate 243-246 hypothetical protein YbiA Escherichia coli 33-37 22399070-6 2012 Likewise, we predict that another family of YbiA-related enzymes is likely to comprise a novel NAD-dependent ADP-ribosylation system for proteins, in conjunction with a previously unrecognized ADP-ribosyltransferase. Adenosine Diphosphate 109-112 hypothetical protein YbiA Escherichia coli 44-48 22294727-6 2012 Expression of P-selectin and activated GPIIb/IIIa in response to high-dose ADP was lower during eltrombopag treatment than at baseline. Adenosine Diphosphate 75-78 integrin subunit alpha 2b Homo sapiens 39-44 22337717-5 2012 An example of an ABC transporter is MRP4 (ABCC4), which facilitates ADP accumulation in dense granules. Adenosine Diphosphate 68-71 ATP binding cassette subfamily C member 4 Homo sapiens 36-40 22337717-5 2012 An example of an ABC transporter is MRP4 (ABCC4), which facilitates ADP accumulation in dense granules. Adenosine Diphosphate 68-71 ATP binding cassette subfamily C member 4 Homo sapiens 42-47 22182832-6 2012 DHEA-S exerted this effect by decreasing thrombin-dependent dense granule secretion, and so impairing the positive feed-back loop provided by ADP. Adenosine Diphosphate 142-145 sulfotransferase family 2A member 1 Homo sapiens 0-6 21733940-5 2012 Anti-beta(2)GP1 antibodies significantly reduced platelet aggregation (percentage area under the curve; %AUC) in a concentration-dependent manner using both 5 mumol/L (P < .001) and 2.5 mumol/L (P = .038) ADP but did not significantly affect the rate of aggregation. Adenosine Diphosphate 208-211 GTP binding protein 1 Homo sapiens 12-15 22623230-10 2012 In patients with CYP2C19*1/*2 and *2/*2 variants, maximal platelet aggregation induced by 5 and 20 mumol/L ADP was reduced by 21.4% (p = 0.006) and 14.3% (p = 0.041), respectively, after 1 month of treatment with omega-3 PUFA as compared to placebo. Adenosine Diphosphate 107-110 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 17-24 23236422-0 2012 A cell permeable NPE caged ADP-ribose for studying TRPM2. Adenosine Diphosphate 27-30 transient receptor potential cation channel subfamily M member 2 Homo sapiens 51-56 22685547-7 2012 We show that the ATP:ADP ratio oscillates, compatible with alternating metabolic activity of the two superclusters and differential feedback on their transcription via activating (RSC) and repressive (Isw2) types of promoter structure remodeling. Adenosine Diphosphate 21-24 DNA translocase Saccharomyces cerevisiae S288C 201-205 21656186-2 2011 CD39 is the dominant vascular endothelial cell ectonucleotidase and rapidly hydrolyses both adenosine triphosphate (ATP) and adenosine diphosphate to adenosine monophosphate. Adenosine Diphosphate 125-146 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 22065753-2 2011 Using solution NMR, we obtained a three-dimensional structure for a 75-kDa Hsp70-DnaJ complex in the ADP state, loaded with substrate peptide. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 4 Homo sapiens 75-80 21807070-2 2011 Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y agonist) and AMP. Adenosine Diphosphate 175-178 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 37-81 21807070-2 2011 Agonist availability is regulated by nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, a family of enzymes that hydrolyze extracellular ATP to generate ADP (a P2Y agonist) and AMP. Adenosine Diphosphate 175-178 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 83-91 22102020-0 2011 ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Adenosine Diphosphate 0-3 ATP citrate lyase Homo sapiens 42-59 21806387-5 2011 RESULTS: In the case of CYP2C19 genotypes, a gene-dose effect was observed in ADP reactivity with the lowest values in GOF homozygotes and the highest degree in patients carrying two LOF alleles. Adenosine Diphosphate 78-81 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 24-31 21808051-6 2011 With ADP present, myoVI acts as an anchor to prevent myoV from stepping forward. Adenosine Diphosphate 5-8 myosin VA Homo sapiens 18-22 21474445-6 2011 The substrate-binding domain of Ssc3 showed poor affinity toward mitochondrial client proteins and Tim44 due to the open conformation in ADP-bound state. Adenosine Diphosphate 137-140 Hsp70 family ATPase ECM10 Saccharomyces cerevisiae S288C 32-36 21474445-6 2011 The substrate-binding domain of Ssc3 showed poor affinity toward mitochondrial client proteins and Tim44 due to the open conformation in ADP-bound state. Adenosine Diphosphate 137-140 protein translocase subunit TIM44 Saccharomyces cerevisiae S288C 99-104 21530487-0 2011 IL-17A increases ADP-induced platelet aggregation. Adenosine Diphosphate 17-20 interleukin 17A Homo sapiens 0-6 21530487-6 2011 Pre-incubation with IL-17A increased ADP-, but not collagen-induced platelet aggregation and accelerated CD62P expression and exposure of fibrinogen binding sites. Adenosine Diphosphate 37-40 interleukin 17A Homo sapiens 20-26 21330915-8 2011 In contrast, RBC in a platelet concentrate matrix enhanced Multiplate aggregation in response to weak agonists (ADP and arachidonic acid). Adenosine Diphosphate 112-115 RNA, 7SL, cytoplasmic 263, pseudogene Homo sapiens 13-16 21347367-6 2011 Once TPX2 binding occurs, switch-1 is forced to "open" the binding site, thus pulling ADP away from Aurora A. Adenosine Diphosphate 86-89 TPX2 microtubule nucleation factor Homo sapiens 5-9 21106949-3 2011 In the presence of a P2Y12 antagonist, preincubation of PRP with ADP inhibited aggregation; this effect was abolished by adenosine deaminase. Adenosine Diphosphate 65-68 adenosine deaminase Homo sapiens 121-140 21299647-6 2011 hsm-1 cells had prolonged origin sequestration, reduced DnaA protein level and reduced DnaA-Reactivating Sequence (DARS)-mediated rejuvenation of DnaA(ADP) to DnaA(ATP) , all of which could contribute to the suppression of RIDA deficiency. Adenosine Diphosphate 151-154 ER membrane protein complex subunit 10 Homo sapiens 0-5 21853082-6 2011 ATP inhibition of CD39L2-catalyzed ADP hydrolysis is also determined for correction of the kinetic data. Adenosine Diphosphate 35-38 ectonucleoside triphosphate diphosphohydrolase 6 Homo sapiens 18-24 21105189-6 2010 TNF-alpha/CCK also enhanced caspases" activity and lactate dehydrogenase release, induced ATP loss, and augmented the ADP/ATP ratio. Adenosine Diphosphate 118-121 cholecystokinin Rattus norvegicus 10-13 20655932-7 2010 Furthermore, the hydrolysis of ATP, ADP, AMP, and p-Nph-5"TMP was also increased (17%, 35%, 27%, 20%, respectively) as was the gene expression of NTPDase2, NTPDase3 and NPP3 in kidneys of hypertensive animals. Adenosine Diphosphate 36-39 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 146-154 20655932-7 2010 Furthermore, the hydrolysis of ATP, ADP, AMP, and p-Nph-5"TMP was also increased (17%, 35%, 27%, 20%, respectively) as was the gene expression of NTPDase2, NTPDase3 and NPP3 in kidneys of hypertensive animals. Adenosine Diphosphate 36-39 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 156-164 20451955-5 2010 The activity of SAA on washed human platelet aggregation was determined by ADP stimulation. Adenosine Diphosphate 75-78 serum amyloid A1 cluster Homo sapiens 16-19 20451955-9 2010 Intravenously administrated SAA (2.5-10 mg/kg) inhibited platelet aggregation induced by ADP in a dose-dependent manner. Adenosine Diphosphate 89-92 serum amyloid A1 cluster Homo sapiens 28-31 20451955-11 2010 In vitro, pretreatment with SAA on washed rat and human platelets significantly inhibited various agonists stimulated platelet aggregation and caused an increase in cAMP level in platelets activated by ADP. Adenosine Diphosphate 202-205 serum amyloid A1 cluster Homo sapiens 28-31 20345719-3 2010 METHODS AND RESULTS: SAA dose-dependently inhibited platelet aggregation induced by ADP, thrombin, collagen and U46619. Adenosine Diphosphate 84-87 serum amyloid A cluster Mus musculus 21-24 20571112-7 2010 Arg-313 of MKK5 is required for ADP-ribosylation by HopF2 and MKK5 function in the plant cell. Adenosine Diphosphate 32-35 MAP kinase kinase 5 Arabidopsis thaliana 11-15 20146261-3 2010 We show in mice that gene deletion of CD39 is associated with marked decreases in phosphohydrolysis of adenosine triphosphate (ATP) and adenosine diphosphate to adenosine monophosphate on NK cells, thereby modulating the type-2 purinergic (P2) receptors demonstrated on these cells. Adenosine Diphosphate 136-157 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 38-42 20118258-5 2010 ORF735 existed in solution as a salt-stable dimer and was capable of assembling into a salt-sensitive oligomer that was significantly larger than a hexamer in the presence of a divalent cation (Mg(2+)) and an adenine nucleotide (ATP, dATP, or ADP) or its analog (ATPgammaS or AMPPNP). Adenosine Diphosphate 243-246 hypothetical protein Saccharolobus solfataricus P2 0-6 20228794-6 2010 We found that myosin V remains highly processive under diagonal loads owing to asymmetrical ADP affinities and that the native 6IQ lever optimizes the subunit coordination, which indicates that myosin V is designed to be an intracellular transporter. Adenosine Diphosphate 92-95 myosin VA Homo sapiens 14-22 20228794-6 2010 We found that myosin V remains highly processive under diagonal loads owing to asymmetrical ADP affinities and that the native 6IQ lever optimizes the subunit coordination, which indicates that myosin V is designed to be an intracellular transporter. Adenosine Diphosphate 92-95 myosin VA Homo sapiens 194-202 20363697-6 2010 Percentage inhibition of the aggregation induced by adenosine diphosphate (ADP) to platelets-rich plasma (PRP) obtained from rats was used as measure for antiplatelet aggregation effect. Adenosine Diphosphate 52-73 proline rich protein 2-like 1 Rattus norvegicus 106-109 20363697-6 2010 Percentage inhibition of the aggregation induced by adenosine diphosphate (ADP) to platelets-rich plasma (PRP) obtained from rats was used as measure for antiplatelet aggregation effect. Adenosine Diphosphate 75-78 proline rich protein 2-like 1 Rattus norvegicus 106-109 20121703-8 2010 Furthermore, denatured proteins decrease the inhibitory influence of ADP on ATP-induced association of GroES to the trans-ring of GroEL. Adenosine Diphosphate 69-72 heat shock protein family D (Hsp60) member 1 Homo sapiens 130-135 20121703-9 2010 From these findings we conclude that denatured proteins facilitate the dissociation of ADP from the trans-ring of GroEL and the concomitant association of ATP and the second GroES. Adenosine Diphosphate 87-90 heat shock protein family D (Hsp60) member 1 Homo sapiens 114-119 20142362-10 2010 Thus, for the first time, we can provide unequivocal proof that ADP-ribosylation can control the outcome of mucosal Ag exposure from tolerance to an enhanced effector CD4(+) T cell response. Adenosine Diphosphate 64-67 CD4 antigen Mus musculus 167-170 20146535-6 2010 We found that LRRK2 follows a rapid equilibrium random mechanism for the phosphorylation of PLK-peptide with either ATP or PLK-peptide being the first substrate binding to the enzyme, as evidenced by initial velocity and inhibition mechanism studies with nucleotide analogues AMP and AMP-PNP, product ADP, and an analogue of the peptide substrate. Adenosine Diphosphate 301-304 polo like kinase 1 Mus musculus 92-95 20083109-0 2010 ATP-triggered ADP release from the asymmetric chaperonin GroEL/GroES/ADP7 is not the rate-limiting step of the GroEL/GroES reaction cycle. Adenosine Diphosphate 14-17 heat shock protein family D (Hsp60) member 1 Homo sapiens 57-62 19861313-1 2010 BACKGROUND: Adenosine, a potent regulator of inflammation, is produced under stressful conditions due to degradation of ATP/ADP by the ectoenzymes CD39 and CD73. Adenosine Diphosphate 124-127 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 147-151 19790263-4 2010 At the post-powerstroke state, we have identified isoform-dependent couplings which underlie the reciprocal coupling between actin binding and nucleotide binding in fast Myosin II, and load-dependent ADP release in Myosin V. Adenosine Diphosphate 200-203 myosin VA Homo sapiens 215-223 20007690-7 2010 It has already been shown that Arl2 localizes to adenine nucleotide transporter 1, the exchanger of ADP/ATP in mitochondria. Adenosine Diphosphate 100-103 ADP-ribosylation factor like GTPase 2 Rattus norvegicus 31-35 19915138-2 2009 The physiological order of addition of ATP and nonnative polypeptide, typically to the open trans ring of an asymmetrical GroEL/GroES/ADP complex, has been unknown, although there have been assumptions that polypeptide binds first, allowing subsequent ATP-mediated movement of the GroEL apical domains to exert an action of forceful unfolding on the nonnative polypeptide. Adenosine Diphosphate 134-137 heat shock protein family D (Hsp60) member 1 Homo sapiens 122-127 19956640-9 2009 The S. cerevisiae Get3 dimer structure does not contain nucleotides and maintains an "open" conformation, while the D. hansenii Get3 dimer structure binds ADP and stays in a "closed" conformation. Adenosine Diphosphate 155-158 guanine nucleotide exchange factor GET3 Saccharomyces cerevisiae S288C 128-132 19783664-5 2009 ADP activated the small GTPase Rac1 and promoted endothelial cell migration. Adenosine Diphosphate 0-3 Rac family small GTPase 1 Homo sapiens 31-35 19783664-6 2009 siRNA-mediated knockdown of Rac1 blocked ADP-dependent eNOS Ser(1179) and Ser(635) phosphorylation, as well as eNOS activation. Adenosine Diphosphate 41-44 Rac family small GTPase 1 Homo sapiens 28-32 19948790-2 2009 To understand the evolution of chemical diversity in the closely related enzymes homoglutathione synthetase (hGS) and glutathione synthetase (GS), we determined the structures of soybean (Glycine max) hGS in three states: apoenzyme, bound to gamma-glutamylcysteine (gammaEC), and with hGSH, ADP, and a sulfate ion bound in the active site. Adenosine Diphosphate 291-294 hepatocyte growth factor-regulated tyrosine kinase substrate Homo sapiens 201-204 19695217-7 2009 These findings suggest a role of STIM1, Orai1 and hTRPC1 in thrombin- and ADP-induced platelet aggregation probably through the regulation of Ca(2+) entry, which might become targets for the development of therapeutic strategies to treat platelet hyperactivity and thrombosis disorders. Adenosine Diphosphate 74-77 ORAI calcium release-activated calcium modulator 1 Homo sapiens 40-45 19695217-7 2009 These findings suggest a role of STIM1, Orai1 and hTRPC1 in thrombin- and ADP-induced platelet aggregation probably through the regulation of Ca(2+) entry, which might become targets for the development of therapeutic strategies to treat platelet hyperactivity and thrombosis disorders. Adenosine Diphosphate 74-77 transient receptor potential cation channel subfamily C member 1 Homo sapiens 50-56 19531481-0 2009 PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Adenosine Diphosphate 11-14 SRY-box transcription factor 2 Homo sapiens 28-32 19531481-0 2009 PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation. Adenosine Diphosphate 11-14 SRY-box transcription factor 2 Homo sapiens 44-48 18846318-5 2009 Injection of IFN-alpha was found to protect mice from death due to the lysis of ADP-induced coronary thrombus. Adenosine Diphosphate 80-83 interferon alpha Mus musculus 13-22 19347762-7 2009 eNOS inhibition decreased the ADP response by 60% in the E25 rats and 50% in the E50 rats, but had no effect in the OVX rats. Adenosine Diphosphate 30-33 nitric oxide synthase 3 Rattus norvegicus 0-4 19429893-8 2009 Finally, we show that RecA-ssDNA filaments can reversibly interconvert between an extended, ATP-bound, and a compressed, ADP-bound state. Adenosine Diphosphate 121-124 RAD51 recombinase Homo sapiens 22-26 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 60-63 myosin VA Homo sapiens 121-129 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 102-105 myosin VA Homo sapiens 121-129 19506755-8 2009 The model makes explicit the energetic cost of accelerating ADP release, showing that acceleration of ADP release during myosin V processivity requires approximately 4 kT of energy whereas the energetic cost for accelerating ADP release in a myosin II-based actin motility assay is only approximately 0.4 kT. Adenosine Diphosphate 102-105 myosin VA Homo sapiens 121-129 19419194-2 2009 Published X-ray crystal structures of yeast guanylate kinase indicate that K14 is part of the "P" loop involved in ATP and ADP binding, while R41 is suggested as a hydrogen bonding partner for the phosphoryl moiety of GMP. Adenosine Diphosphate 123-126 guanylate kinase Saccharomyces cerevisiae S288C 44-60 19419194-4 2009 Adenosine conformations of ATP and ADP and guanosine conformations of GMP bound to R41M and K14M mutant yeast guanylate kinase in the complexes GKy.MgATP, GKy.MgADP, and GKy.MgADP. Adenosine Diphosphate 35-38 guanylate kinase Saccharomyces cerevisiae S288C 110-126 19419194-4 2009 Adenosine conformations of ATP and ADP and guanosine conformations of GMP bound to R41M and K14M mutant yeast guanylate kinase in the complexes GKy.MgATP, GKy.MgADP, and GKy.MgADP. Adenosine Diphosphate 159-164 guanylate kinase Saccharomyces cerevisiae S288C 110-126 19419194-4 2009 Adenosine conformations of ATP and ADP and guanosine conformations of GMP bound to R41M and K14M mutant yeast guanylate kinase in the complexes GKy.MgATP, GKy.MgADP, and GKy.MgADP. Adenosine Diphosphate 174-179 guanylate kinase Saccharomyces cerevisiae S288C 110-126 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 31-35 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 49-52 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 31-35 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 182-186 19377479-5 2009 Human MSH2-MSH3 and yeast Msh2-Msh6 both undergo ADP-ATP exchange in the Msh2 subunit but, apparently, have opposite requirements for ATP hydrolysis: ADP release from DNA-bound Msh2-Msh6 requires ATP stabilization in the Msh6 subunit, whereas ADP release from DNA-bound MSH2-MSH3 requires ATP hydrolysis in the MSH3 subunit. Adenosine Diphosphate 150-153 mismatch repair ATPase MSH6 Saccharomyces cerevisiae S288C 31-35 19023091-4 2009 Signaling downstream of PAR-1 or PAR-4 activates phospholipase C and protein kinase C and causes autoamplification by production of thromboxane A(2), release of ADP, and generation of more thrombin. Adenosine Diphosphate 161-164 F2R like thrombin or trypsin receptor 3 Homo sapiens 33-38 19336004-1 2009 Hsp70s assist in the process of protein folding through nucleotide-controlled cycles of substrate binding and release by alternating from an ATP-bound state in which the affinity for substrate is low to an ADP-bound state in which the affinity for substrate is high. Adenosine Diphosphate 206-209 heat shock protein family A (Hsp70) member 4 Homo sapiens 0-5 19336004-5 2009 The results of these experiments showed that ATP had a larger effect on the conformation of Hsp70 than ADP. Adenosine Diphosphate 103-106 heat shock protein family A (Hsp70) member 4 Homo sapiens 92-97 19146391-5 2009 Analyses of enzymatic reactions catalyzed by NS4B indicate that the terminal phosphate groups of ATP, GTP, and GDP are removed to produce ADP, GDP, and GMP, respectively. Adenosine Diphosphate 138-141 polyprotein;protein F Hepatitis C virus genotype 1 45-49 19154428-4 2009 Alternative conversion of ATP into ADP by ecto-ATPase (adenosine 5"-triphosphatase) was more relevant at high ATP concentrations. Adenosine Diphosphate 35-38 CEA cell adhesion molecule 1 Rattus norvegicus 42-53 18626658-1 2009 UCP2 is expressed in pancreatic beta cells where its postulated uncoupling activity will modulate glucose-induced changes in ATP/ADP ratio and insulin secretion. Adenosine Diphosphate 129-132 uncoupling protein 2 Rattus norvegicus 0-4 19947384-9 2009 This is built-in into the translation machine and based on dependence of recirculation rate of eukaryotic initiation factor 2 (elF2) from ATP/ADP value that is created by mitochondrial bio-energetic machine. Adenosine Diphosphate 142-145 E74 like ETS transcription factor 2 Homo sapiens 127-131 19134468-2 2009 Biochemical and single molecule mechanical studies have led to a model in which a slow ADP release step contributes to the processivity of myosin-V. Adenosine Diphosphate 87-90 myosin VA Homo sapiens 139-147 19049516-3 2009 The reaction requires physical contact between myokinase and adenosine kinase, and the net reaction is aided by the presence of adenosine deaminase (EC 3.5.4.4), which fills the gap in the energy balance of the phosphoryl transfer and shifts the equilibrium towards ADP and inosine synthesis. Adenosine Diphosphate 266-269 adenosine deaminase Rattus norvegicus 128-147 19126390-7 2009 2 positive phage antibodies with high specific for GP IIb/IIIa were verified, and the purified antibody can inhibited ADP induced platelet aggregation. Adenosine Diphosphate 118-121 integrin subunit alpha 2b Homo sapiens 51-57 18805923-2 2008 It was found that the nucleotide binding site within Arp3 remained in a closed position with bound ATP or ADP, but opened when simulation with no nucleotide was performed. Adenosine Diphosphate 106-109 actin related protein 3 Homo sapiens 53-57 19029896-1 2008 Cochaperones are essential for Hsp70- and Hsc70-mediated folding of proteins and include nucleotide-exchange factors (NEFs) that assist protein folding by accelerating ADP-ATP exchange on Hsp70. Adenosine Diphosphate 168-171 heat shock protein family A (Hsp70) member 4 Homo sapiens 31-36 19029896-1 2008 Cochaperones are essential for Hsp70- and Hsc70-mediated folding of proteins and include nucleotide-exchange factors (NEFs) that assist protein folding by accelerating ADP-ATP exchange on Hsp70. Adenosine Diphosphate 168-171 heat shock protein family A (Hsp70) member 4 Homo sapiens 188-193 18923018-8 2008 Furthermore, the kinetics are substantially different from those of this carrier, with ADNT1 preferring AMP to ADP. Adenosine Diphosphate 111-114 adenine nucleotide transporter 1 Arabidopsis thaliana 87-92 18782766-6 2008 Strikingly, assembly of the folding-active GroEL-GroES complex appears to involve a strategic delay in ATP hydrolysis that is coupled to disassembly of the old, ADP-bound GroEL-GroES complex on the opposite ring. Adenosine Diphosphate 161-164 heat shock protein family D (Hsp60) member 1 Homo sapiens 43-48 18782766-6 2008 Strikingly, assembly of the folding-active GroEL-GroES complex appears to involve a strategic delay in ATP hydrolysis that is coupled to disassembly of the old, ADP-bound GroEL-GroES complex on the opposite ring. Adenosine Diphosphate 161-164 heat shock protein family D (Hsp60) member 1 Homo sapiens 171-176 18988745-7 2008 ATP added to the asymmetric GroEL-GroES resting-state complex lacking trans ring ADP is hydrolyzed in the newly formed cis ring with a presteady-state burst of approximately 6 mol of Pi per mole of 14-mer. Adenosine Diphosphate 81-84 heat shock protein family D (Hsp60) member 1 Homo sapiens 28-33 18678871-3 2008 Here we show that this low FAD/protein ratio is the result of tight binding of ADP, thereby competing with FAD binding. Adenosine Diphosphate 79-82 BRCA2 DNA repair associated Homo sapiens 27-30 18678871-3 2008 Here we show that this low FAD/protein ratio is the result of tight binding of ADP, thereby competing with FAD binding. Adenosine Diphosphate 79-82 BRCA2 DNA repair associated Homo sapiens 107-110 18521569-12 2008 CONCLUSIONS: ATP and ADP at high-micromolar concentrations reduce secretion of the main Th1 cytokines TNFalpha, IL-12(p70) and IFNgamma in LPS stimulated human blood. Adenosine Diphosphate 21-24 negative elongation factor complex member C/D Homo sapiens 88-91 18567585-8 2008 Considering the concentrations of ADP and ATP in E. coli, ADP is expected to have a small effect on the inhibition of GroES binding to the trans-ring of GroEL in vivo. Adenosine Diphosphate 34-37 chaperonin GroES Escherichia coli 118-123 18567585-8 2008 Considering the concentrations of ADP and ATP in E. coli, ADP is expected to have a small effect on the inhibition of GroES binding to the trans-ring of GroEL in vivo. Adenosine Diphosphate 58-61 chaperonin GroES Escherichia coli 118-123 18704301-9 2008 It is concluded that the treatment with anti-CD4 McAb could prevent the activation of T cells, reverse the abnormal secretion of cytokines and the imbalance between Th1/Th2 cell subsets and abnormal production of autoantibody against ADP/ATP carrier, and eventually avoid myocardial injuries. Adenosine Diphosphate 234-237 CD4 antigen Mus musculus 45-48 18566910-1 2008 The chloroplast ATP synthase synthesizes ATP from ADP and free phosphate coupled by the electrochemical potential across the thylakoid membrane in the light. Adenosine Diphosphate 50-53 ATP synthase Arabidopsis thaliana 16-28 18550409-2 2008 Their activities are regulated by proteins that exchange ADP for ATP from the nucleotide-binding domain (NBD) of the Hsp70. Adenosine Diphosphate 57-60 heat shock protein family A (Hsp70) member 4 Homo sapiens 117-122 18471985-7 2008 These results strongly suggest that the ADP-induced phosphorylation of HSP27 via p44/p42 MAPK and/or p38 MAPK is therefore sufficient for platelet granule secretion but not for platelet aggregation in humans. Adenosine Diphosphate 40-43 erythrocyte membrane protein band 4.2 Homo sapiens 85-88 18431598-2 2008 Disruption of SAL1 is synthetically lethal with the loss of a specific function associated with the Aac2 isoform of the ATP/ADP translocase. Adenosine Diphosphate 124-127 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 14-18 18509050-6 2008 Loads applied in either direction slow ADP binding to myosin V but accelerate binding to myosin VI. Adenosine Diphosphate 39-42 myosin VA Homo sapiens 54-62 18311542-10 2008 We also show that ZmIPT2 preferentially uses ADP and ATP over AMP as the substrates for dimethylallyl diphosphate (DMAPP) IPT activity. Adenosine Diphosphate 45-48 adenylate isopentenyltransferase 5, chloroplastic Zea mays 18-24 18311542-10 2008 We also show that ZmIPT2 preferentially uses ADP and ATP over AMP as the substrates for dimethylallyl diphosphate (DMAPP) IPT activity. Adenosine Diphosphate 45-48 isopentenyl transferase Zea mays 20-23 18394438-5 2008 After covariate adjustment, the CYP2C19*2 allele was more frequent in clopidogrel nonresponders, defined by persistent high post-treatment platelet reactivity (ADP-induced platelet aggregation >70%; p = 0.03). Adenosine Diphosphate 160-163 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 32-39 18201966-6 2008 Nevertheless, the ADP affinity of actomyosin Vc (K(d) = 0.25 +/- 0.02 microm) reflects a higher ADP affinity than seen in other myosin V isoforms. Adenosine Diphosphate 18-21 myosin VA Homo sapiens 38-46 18201966-6 2008 Nevertheless, the ADP affinity of actomyosin Vc (K(d) = 0.25 +/- 0.02 microm) reflects a higher ADP affinity than seen in other myosin V isoforms. Adenosine Diphosphate 96-99 myosin VA Homo sapiens 38-46 18174464-6 2008 ADP also stimulated phosphorylation of p90RSK, a downstream substrate of phosphorylated ERK1/2, and induced phosphorylation of such transcription factors downstream of the JNK and p38 pathways as c-Jun and activating transcription factor-2. Adenosine Diphosphate 0-3 activating transcription factor 2 Homo sapiens 206-239 18155236-5 2008 The nucleotide cleft of Arp3 opened in most simulations with ATP, ADP, and no bound nucleotide. Adenosine Diphosphate 66-69 actin related protein 3 Homo sapiens 24-28 18202825-1 2008 Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). Adenosine Diphosphate 5-8 apoptosis inducing factor mitochondria associated 1 Homo sapiens 99-124 18202825-1 2008 Poly(ADP-ribose) (PAR) has been identified as a DNA damage-inducible cell death signal upstream of apoptosis-inducing factor (AIF). Adenosine Diphosphate 5-8 apoptosis inducing factor mitochondria associated 1 Homo sapiens 126-129 18457363-7 2008 550 mg/kg/day SA or NG for 5 days could significantly inhibit ADP-induced platelet aggregation of PRP. Adenosine Diphosphate 62-65 proline rich protein 2-like 1 Rattus norvegicus 98-101 17824844-9 2008 We propose that the high mitochondrial proton leak in beta-cells is a mechanism which amplifies the effect of physiological UCP2 regulators on cytoplasmic ATP/ADP and hence on insulin secretion. Adenosine Diphosphate 159-162 uncoupling protein 2 Rattus norvegicus 124-128 17913711-3 2007 To understand the molecular structural basis of enzyme regulation by PII, we have determined a 2.5-A resolution crystal structure of a complex formed between two homotrimers of PII and a single hexamer of NAGK from Arabidopsis thaliana bound to the metabolites N-acetylglutamate, ADP, ATP, and arginine. Adenosine Diphosphate 280-283 N-acetyl-l-glutamate kinase Arabidopsis thaliana 205-209 17683357-8 2007 At 20% and 40% dilutions, ADP and TRAP-induced expression of activated platelet surface GP IIb/IIIa was significantly increased by B-HES compared to NB-HES and RL. Adenosine Diphosphate 26-29 integrin subunit alpha 2b Homo sapiens 88-94 17683357-13 2007 B-HES but not NB-HES increases the expression of activated platelet GP IIb/IIIa induced by ADP or TRAP. Adenosine Diphosphate 91-94 integrin subunit alpha 2b Homo sapiens 68-74 17606897-5 2007 These experiments define a unique set of biochemical activities of Otop1, including depletion of endoplasmic reticulum Ca(2+) stores, specific inhibition of the purinergic receptor P2Y, and regulation of the influx of extracellular Ca(2+) in response to ATP, ADP, and UDP. Adenosine Diphosphate 259-262 otopetrin 1 Homo sapiens 67-72 17507377-6 2007 Functional analyses revealed that the doubly mutated chimeric enzymes almost completely acquired most of the different regulatory preferences between hGDH1 and hGDH2 for electrophoretic mobility, heat-stability, ADP activation, palmitoyl-CoA inhibition, and l-leucine activation, except for GTP inhibition. Adenosine Diphosphate 212-215 glutamate dehydrogenase 2 Homo sapiens 160-165 17510632-2 2007 For myosin V, internal strain produced when both heads of are attached to an actin track prevents completion of the lever arm swing of the lead head and blocks ADP release. Adenosine Diphosphate 160-163 myosin VA Homo sapiens 4-12 17311891-2 2007 Channels comprised of Kir6.2 and SUR1 subunits function in subpopulations of mediobasal hypothalamic (MBH) neurons as an essential component of a glucose-sensing mechanism in these cells, wherein uptake and metabolism of glucose leads to increase in intracellular ATP/ADP, closure of the channels, and increase in neuronal excitability. Adenosine Diphosphate 268-271 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 22-28 17456547-5 2007 Using actin co-sedimentation, we demonstrate that coronin 1B binds with high affinity to ATP/ADP-P(i)-F-actin (170 nM) and with 47-fold lower affinity to ADP-F-actin (8 microM). Adenosine Diphosphate 93-96 coronin 1B Homo sapiens 50-60 17253646-5 2007 Functional analyses of highly purified recombinant wild-type hGDH2 revealed that this adaptive evolution dissociated the enzyme from GTP control, permitted regulation almost entirely by ADP and/or L-leucine, and fine-tuned its activity to the relatively low cellular pH that occurs in synaptic astrocytes during excitatory transmission. Adenosine Diphosphate 186-189 glutamate dehydrogenase 2 Homo sapiens 61-66 17276460-11 2007 We report the structure of the APS-kinase domain of human PAPSS1 in complex with two APS molecules, demonstrating the ability of the ATP/ADP-binding site to bind APS. Adenosine Diphosphate 137-140 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Homo sapiens 58-64 17397263-7 2007 AvrB residues that contact adenosine diphosphate are also required for initiation of RPM1 function. Adenosine Diphosphate 27-48 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 85-89 17003372-4 2007 alphaIIbbeta3 activation by ADP or a Par4 thrombin receptor agonist was also decreased in ADAP-/- platelets. Adenosine Diphosphate 28-31 FYN binding protein Mus musculus 90-94 17244533-2 2007 Here we present the electron cryomicroscopy reconstruction of an ATP-activated ClpB trap mutant, along with reconstructions of ClpB in the AMPPNP, ADP, and in the nucleotide-free state. Adenosine Diphosphate 147-150 caseinolytic mitochondrial matrix peptidase chaperone subunit B Homo sapiens 127-131 17986831-5 2007 Autosomal dominant mutations in the genes encoding glucokinase (GCK) and glutamate dehydrogenase (GLUD1) lead to inappropriate insulin secretion by increasing the ATP/ADP ratio in the Beta-cells. Adenosine Diphosphate 167-170 glucokinase Homo sapiens 51-62 17986831-5 2007 Autosomal dominant mutations in the genes encoding glucokinase (GCK) and glutamate dehydrogenase (GLUD1) lead to inappropriate insulin secretion by increasing the ATP/ADP ratio in the Beta-cells. Adenosine Diphosphate 167-170 glucokinase Homo sapiens 64-67 18008114-11 2007 CONCLUSION: Our results demonstrated that the existence of intracellular MgADP and protons attenuated the direct inhibitory potency of propofol on recombinant cardiac sarcolemmal K(ATP) channels, via SUR2A and Kir6.2 subunits, respectively. Adenosine Diphosphate 73-78 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 210-216 17239165-7 2007 ADP-induced GPIIb/IIIa activation showed the same pattern as LTA (r = 0.74). Adenosine Diphosphate 0-3 integrin subunit alpha 2b Homo sapiens 12-17 17195847-2 2007 Here we report the structures of the cytoplasmic domain of the human transporter ClC-5 in complex with ATP and ADP. Adenosine Diphosphate 111-114 chloride voltage-gated channel 5 Homo sapiens 81-86 17337041-13 2007 CONCLUSIONS: Our data show that, in patients with stable CAD, an increased platelet reactivity to C/ADP stimulation after exercise, as assessed by the PFA-100 method, is specifically associated with an increased expression of platelet GP IIb/IIIa receptor. Adenosine Diphosphate 100-103 integrin subunit alpha 2b Homo sapiens 235-241 17451792-9 2007 In PRP diluted with autologous PPP, ADP-induced platelet aggregation rate was only 9.10%. Adenosine Diphosphate 36-39 proline rich protein 2-like 1 Rattus norvegicus 3-6 17451792-10 2007 However, in PRP diluted with Tyrode"s buffer, 1 microM ADP-induced platelet aggregation rate rose to 63.65%. Adenosine Diphosphate 55-58 proline rich protein 2-like 1 Rattus norvegicus 12-15 17451792-11 2007 In PRP diluted with Tyrode"s buffer, and pretreated with DHT (1 nM, 2 nM), ADP-induced platelet aggregation was significantly lowered again. Adenosine Diphosphate 75-78 proline rich protein 2-like 1 Rattus norvegicus 3-6 16997870-7 2006 These changes are apparent from the increase in the fluorescence intensity of F-actin bound epsilon-ADP upon cofilin binding and a decrease in its accessibility to collisional quenchers. Adenosine Diphosphate 100-103 cofilin Saccharomyces cerevisiae S288C 109-116 17135353-1 2006 The chaperonin GroEL-GroES, a machine that helps proteins to fold, cycles through a number of allosteric states, the T state, with high affinity for substrate proteins, the ATP-bound R state, and the R" (GroEL-ADP-GroES) complex. Adenosine Diphosphate 210-213 heat shock protein family D (Hsp60) member 1 Homo sapiens 15-20 17135353-1 2006 The chaperonin GroEL-GroES, a machine that helps proteins to fold, cycles through a number of allosteric states, the T state, with high affinity for substrate proteins, the ATP-bound R state, and the R" (GroEL-ADP-GroES) complex. Adenosine Diphosphate 210-213 heat shock protein family D (Hsp60) member 1 Homo sapiens 204-209 16945967-3 2006 Experiments with permeabilized myocytes revealed that with normal cytosolic energy reserves (mm: ATP 5, ADP 0.01, phosphocreatine (CrP) 10) fructose-1,6-bisphosphate (FBP; 1 mm) and fructose-6-phosphate (F6P; 1 mm) caused a transient increase of Ca(2+) spark frequency by 62 and 42%, respectively. Adenosine Diphosphate 104-107 fructose-bisphosphatase 1 Homo sapiens 140-165 17085600-7 2006 Otherwise, as in Drosophila embryonic muscle and other slow muscle types, a step associated with MgADP release limits muscle contraction speed by delaying the detachment of myosin from actin. Adenosine Diphosphate 97-102 zipper Drosophila melanogaster 173-179 16987338-9 2006 HES200/0.5 and HES130/0.4 reduced the CD42b, CD41/61 and CD62p expression of ADP-agonist-activated platelets at 15 min after intravenous infusion. Adenosine Diphosphate 77-80 integrin subunit alpha 2b Homo sapiens 45-52 16963786-5 2006 Upon complex formation with co-chaperonin GroES in the presence of ADP, Tyr478 exhibits two peaks that would originate from the cis and trans rings of the asymmetric GroEL-GroES complex. Adenosine Diphosphate 67-70 heat shock protein family D (Hsp60) member 1 Homo sapiens 166-171 16857711-7 2006 In addition, the electrophysiological and pharmacological properties of the non-selective cation channels stimulated by the physiological agonist ADP are consistent with a major role for TRPC6 in this G-protein-coupled receptor-dependent Ca(2+) influx pathway. Adenosine Diphosphate 146-149 transient receptor potential cation channel, subfamily C, member 6 Mus musculus 187-192 16981703-7 2006 In this study we utilize MANT-ATP, a fluorescent analogue of ATP, to monitor the rate constants for binding of ATP as well as the release of ADP from Escherichia coli Lon protease. Adenosine Diphosphate 141-144 putative ATP-dependent Lon protease Escherichia coli 167-170 16981703-9 2006 On the basis of the data obtained in this study we propose that the rate of ADP release is slightly different for the two ATPase sites. Adenosine Diphosphate 76-79 ATPase Escherichia coli 122-128 16964980-2 2006 Loss of the ability to form the hydrogen bonds involving alphaS337, betaD301, and alphaD335 lowered the k(cat) of ATPase and decreased its susceptibility to Mg(2+)-ADP-AlF(n) inhibition, while mutations that maintain or strengthen these bonds increased the susceptibility to Mg(2+)-ADP-AlF(n) inhibition and lowered the k(cat) of ATPase. Adenosine Diphosphate 164-167 ATPase Escherichia coli 114-120 16964980-2 2006 Loss of the ability to form the hydrogen bonds involving alphaS337, betaD301, and alphaD335 lowered the k(cat) of ATPase and decreased its susceptibility to Mg(2+)-ADP-AlF(n) inhibition, while mutations that maintain or strengthen these bonds increased the susceptibility to Mg(2+)-ADP-AlF(n) inhibition and lowered the k(cat) of ATPase. Adenosine Diphosphate 164-167 ATPase Escherichia coli 330-336 16815340-5 2006 Here, we characterize the distribution of NTPDase3 ectonucleotidase (preferentially hydrolyzes ATP over ADP) in cochlear tissues and investigate the effect of noise exposure on NTPDase3 expression. Adenosine Diphosphate 104-107 ectonucleoside triphosphate diphosphohydrolase 3 Rattus norvegicus 42-50 16582021-1 2006 Poly(ADP-ribose) polymerase-1 (PARP-1), the most abundant member of the PARP family, is a nuclear enzyme that catalyzes ADP-ribose transfer from NAD+ to specific acceptor proteins in response to DNA damage. Adenosine Diphosphate 5-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 31-37 16582021-1 2006 Poly(ADP-ribose) polymerase-1 (PARP-1), the most abundant member of the PARP family, is a nuclear enzyme that catalyzes ADP-ribose transfer from NAD+ to specific acceptor proteins in response to DNA damage. Adenosine Diphosphate 5-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 31-35 17015265-2 2006 We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1). Adenosine Diphosphate 23-26 mitogen activated protein kinase kinase 4 Rattus norvegicus 224-228 17015265-2 2006 We show here that the NADPH oxidase-dependent production of O2*(-) and H2O2 or respiratory burst in alveolar macrophages (AM) (NR8383 cells) is required for ADP-stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 (but not MKK7) and apoptosis signal-regulating kinase-1 (ASK1). Adenosine Diphosphate 23-26 mitogen activated protein kinase kinase 7 Rattus norvegicus 238-242 17015265-6 2006 These results demonstrate that the ADP-stimulated respiratory burst activated the ASK1-MKK4-JNK1/c-Jun signaling pathway in AM and suggest that transient and localized oxidation of Trx by the NADPH oxidase-mediated generation of H2O2 may play a critical role in ASK1 activation and the inflammatory response. Adenosine Diphosphate 35-38 mitogen activated protein kinase kinase 4 Rattus norvegicus 87-91 16752176-0 2006 Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets. Adenosine Diphosphate 86-89 pyruvate carboxylase Rattus norvegicus 16-36 16752176-6 2006 RESULTS: We found that the glucose-provoked rise in ATP:ADP ratio was suppressed by inhibition of pyruvate carboxylase. Adenosine Diphosphate 56-59 pyruvate carboxylase Rattus norvegicus 98-118 16752176-11 2006 These processes, controlled by pyruvate carboxylase, seem crucial for generation of an appropriate ATP:ADP ratio, which may regulate both phases of fuel-induced insulin secretion. Adenosine Diphosphate 103-106 pyruvate carboxylase Rattus norvegicus 31-51 16752921-10 2006 In contrast to the chicken E-NTPDase 8, the human E-NTPDase 8 hydrolyzes MgADP poorly and is inhibited by several detergents as well as benzyl alcohol; the latter attribute may be related to weaker interaction of the transmembranous domains of the human E-NTPDase 8. Adenosine Diphosphate 73-78 ectonucleoside triphosphate diphosphohydrolase 8 Gallus gallus 27-38 16616242-1 2006 BACKGROUND: CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase-1]) expressed on the luminal surface of endothelial cells rapidly metabolizes extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP), and abrogates platelet reactivity. Adenosine Diphosphate 195-216 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-16 16616242-1 2006 BACKGROUND: CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase-1]) expressed on the luminal surface of endothelial cells rapidly metabolizes extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP), and abrogates platelet reactivity. Adenosine Diphosphate 195-216 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 62-71 16616242-1 2006 BACKGROUND: CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase-1]) expressed on the luminal surface of endothelial cells rapidly metabolizes extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP), and abrogates platelet reactivity. Adenosine Diphosphate 218-221 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 12-16 16616242-1 2006 BACKGROUND: CD39 (nucleoside triphosphate diphosphohydrolase [NTPDase-1]) expressed on the luminal surface of endothelial cells rapidly metabolizes extracellular adenosine triphosphate (ATP) and adenosine diphosphate (ADP) to adenosine monophosphate (AMP), and abrogates platelet reactivity. Adenosine Diphosphate 218-221 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 62-71 16616242-5 2006 The catalytic efficiency (kcat/Km) of CD39-mediated phosphohydrolysis of ADP and ATP was determined both for detergent-solubilized and protein-reconstituted CD39 within lipid membranes. Adenosine Diphosphate 73-76 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 38-42 16616242-5 2006 The catalytic efficiency (kcat/Km) of CD39-mediated phosphohydrolysis of ADP and ATP was determined both for detergent-solubilized and protein-reconstituted CD39 within lipid membranes. Adenosine Diphosphate 73-76 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 157-161 16616242-6 2006 The capacity of CD39-containing lipid vesicles to inhibit platelet activation induced by ADP, collagen, or thrombin was determined in vitro by platelet aggregometry. Adenosine Diphosphate 89-92 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 16-20 16616242-10 2006 Furthermore, CD39 lipid vesicles effectively inhibited platelet aggregation when activated by ADP, collagen, or thrombin, and also promoted platelet disaggregation (60.4% +/- 6.1%). Adenosine Diphosphate 94-97 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 13-17 16421443-6 2006 The crystal structure of dCK has been solved previously in complex with pyrimidine nucleosides and ADP [Sabini et al. Adenosine Diphosphate 99-102 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 25-28 16421443-10 2006 In the current study, the crystal structure of clofarabine- and ADP-bound dCK was solved to 2.55 angstroms by molecular replacement. Adenosine Diphosphate 64-67 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 74-77 16420577-7 2006 Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine. Adenosine Diphosphate 224-227 F2R like thrombin or trypsin receptor 3 Homo sapiens 133-137 16685599-3 2006 TRPC3 and TRPC4 are activated by oxidants, which induce Na(+) and Ca(2+) entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFalpha, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Adenosine Diphosphate 241-244 transient receptor potential cation channel subfamily M member 2 Homo sapiens 303-308 16141393-1 2005 Chaperone proteins in the heat shock protein-70 family possess endogenous ATP binding and ATPase activity and interact with intracellular protein substrates in an ATP-dependent manner; the hydrolysis of ATP to ADP results in an increase in the affinity of the chaperone for protein substrates. Adenosine Diphosphate 210-213 heat shock protein family A (Hsp70) member 8 Homo sapiens 26-47 16141393-8 2005 These results suggest that ATP hydrolysis to ADP would favor the release of vitamin D from a donor hsc70 molecule at a time when an hsc70-bound acceptor protein substrate is anchored to the chaperone with relative avidity. Adenosine Diphosphate 45-48 heat shock protein family A (Hsp70) member 8 Homo sapiens 99-104 16141393-8 2005 These results suggest that ATP hydrolysis to ADP would favor the release of vitamin D from a donor hsc70 molecule at a time when an hsc70-bound acceptor protein substrate is anchored to the chaperone with relative avidity. Adenosine Diphosphate 45-48 heat shock protein family A (Hsp70) member 8 Homo sapiens 132-137 16299328-10 2005 The chemokine RANTES enhanced platelet aggregation induced by SDF-1alpha, macrophage-derived chemokine, or thymus and activation-regulated chemokine in the presence of very low ADP levels. Adenosine Diphosphate 177-180 C-C motif chemokine ligand 5 Homo sapiens 14-20 16044034-9 2005 However, spermine inhibits the ADP- or thrombin-induced activation of GP IIb/IIIa. Adenosine Diphosphate 31-34 integrin subunit alpha 2b Homo sapiens 70-76 16051170-6 2005 Consistent with this requirement for simultaneous contacts with Arp2/3 and F-actin, cortactin is recruited by Arp2/3 complex to lamellipodia and binds with a higher affinity to ATP/ADP-Pi-F-actin than to ADP-F-actin. Adenosine Diphosphate 181-184 cortactin Homo sapiens 84-93 15917244-11 2005 In the case of hRad51 protein, Ca2+ acts primarily by inhibiting its ATPase activity, thereby preventing self-conversion into an inactive ADP-bound complex. Adenosine Diphosphate 138-141 RAD51 recombinase Homo sapiens 15-21 15996167-3 2005 This study was conducted to investigate the association of HLA-DQA1, -DQB1 allele polymorphisms with an autoantibody against the myocardial mitochondria ADP/ATP carrier, and to explore susceptibility to idiopathic dilated cardiomyopathy (IDC) among the Han ethnic group in northern China and the immunological mechanisms and hereditary susceptibility to IDC. Adenosine Diphosphate 153-156 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 70-74 18404504-6 2005 In contrast, NTPDases 2, 3 and 8 are expected to promote the activation of ADP specific receptors, because in the presence of ATP they produce a sustained (NTPDase2) or transient (NTPDases 3 and 8) accumulation of ADP. Adenosine Diphosphate 75-78 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 156-164 15677308-4 2005 The key enzyme involved in polymer turnover is PARG, which possesses mainly exoglycosidase activity but can remove olig(ADP-ribose) fragments via endoglycosidic cleavage. Adenosine Diphosphate 120-123 poly (ADP-ribose) glycohydrolase Mus musculus 47-51 16413268-1 2005 BIG1 and BIG2 are large (approximately 200 kDa) guanine nucleotide-exchange proteins for ADP-ribosylation factors, or ARFs, that were isolated based on sensitivity of their guanine nucleotide-exchange activity to inhibition by brefeldin A. Adenosine Diphosphate 89-92 ADP ribosylation factor guanine nucleotide exchange factor 1 Homo sapiens 0-4 16413268-1 2005 BIG1 and BIG2 are large (approximately 200 kDa) guanine nucleotide-exchange proteins for ADP-ribosylation factors, or ARFs, that were isolated based on sensitivity of their guanine nucleotide-exchange activity to inhibition by brefeldin A. Adenosine Diphosphate 89-92 ADP ribosylation factor guanine nucleotide exchange factor 2 Homo sapiens 9-13 15647162-5 2004 The recently published evidence for a strain-sensing mechanism involving ADP release for slower muscle myosins, and in particular non-muscle myosins, is more compelling and can provide the mechanism of processivity for motors such as myosin V. Adenosine Diphosphate 73-76 myosin VA Homo sapiens 234-242 15585881-9 2004 ADP, ATP, adenosine 5"-O-(3-thiotriphosphate), and 2",3"-O-(4-benzoyl-benzoyl) adenosine 5"-triphosphate each induced cAMP accumulation, stimulated the phosphorylation of CREB, and up-regulated the expression of inducible cAMP early repressor, a CREB-dependent inhibitor of cytokine transcription. Adenosine Diphosphate 0-3 cAMP responsive element binding protein 1 Homo sapiens 171-175 15585881-9 2004 ADP, ATP, adenosine 5"-O-(3-thiotriphosphate), and 2",3"-O-(4-benzoyl-benzoyl) adenosine 5"-triphosphate each induced cAMP accumulation, stimulated the phosphorylation of CREB, and up-regulated the expression of inducible cAMP early repressor, a CREB-dependent inhibitor of cytokine transcription. Adenosine Diphosphate 0-3 cAMP responsive element binding protein 1 Homo sapiens 246-250 15681758-12 2004 Thus, ADP-ribosylation was necessary for a strong enhancing effect of immune responses following CT/CTB-dependent delivery of antigen to the MZ DCs. Adenosine Diphosphate 6-9 phosphate cytidylyltransferase 1B, choline Homo sapiens 97-99 15681758-12 2004 Thus, ADP-ribosylation was necessary for a strong enhancing effect of immune responses following CT/CTB-dependent delivery of antigen to the MZ DCs. Adenosine Diphosphate 6-9 phosphate cytidylyltransferase 1B, choline Homo sapiens 100-103 15347676-0 2004 Sites of the NUDT9-H domain critical for ADP-ribose activation of the cation channel TRPM2. Adenosine Diphosphate 41-44 transient receptor potential cation channel subfamily M member 2 Homo sapiens 85-90 15292259-4 2004 We have determined the structure of the N-domain of GRP94 in complex with ATP, ADP, and AMP. Adenosine Diphosphate 79-82 heat shock protein 90 beta family member 1 Homo sapiens 52-57 15347650-4 2004 In ADP, the substrate protein-loaded GroEL cannot bind GroES. Adenosine Diphosphate 3-6 heat shock protein family D (Hsp60) member 1 Homo sapiens 37-42 15359274-4 2004 Conversely, ADP promotes the dissociation of Isw2 from DNA. Adenosine Diphosphate 12-15 DNA translocase Saccharomyces cerevisiae S288C 45-49 15549272-3 2004 Here we demonstrate, using patch clamp electrophysiology, that the antifungal imidazoles clotrimazole and econazole inhibit ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Adenosine Diphosphate 124-127 transient receptor potential cation channel subfamily M member 2 Homo sapiens 200-205 15549272-3 2004 Here we demonstrate, using patch clamp electrophysiology, that the antifungal imidazoles clotrimazole and econazole inhibit ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Adenosine Diphosphate 124-127 transient receptor potential cation channel subfamily M member 2 Homo sapiens 207-213 15381407-8 2004 Interestingly, steady-state kinetic analyses revealed that the isopentenylation of ADP and ATP were more efficient than that of AMP as previously reported for A. thaliana AtIPT4. Adenosine Diphosphate 83-86 isopentenyltransferase 4 Arabidopsis thaliana 171-177 15291820-5 2004 The protein displays low intrinsic ATPase activity with ADP and phosphate as the products, the apparent K(m) being 25 micro m and the k(cat) 1.7 x 10(-3) s(-1). Adenosine Diphosphate 56-59 ATPase Escherichia coli 35-41 15273304-7 2004 Examining Hsc70 interdomain energetics, we propose that long-range electrostatic interactions, perhaps due to a difference in the pKa values of bound ATP and ADP, could play a major role in the structural change induced by ATP hydrolysis. Adenosine Diphosphate 158-161 heat shock protein family A (Hsp70) member 8 Homo sapiens 10-15 15296740-3 2004 We determined the crystal structure of the native GroEL-GroES-ADP homolog from Thermus thermophilus, with substrate proteins in the cis-cavity, at 2.8 A resolution. Adenosine Diphosphate 62-65 chaperonin GroES Escherichia coli 56-61 15240102-5 2004 Based on the high resolution structure of a subunit of the bovine ADP/ATP translocase, on sequence similarities between members of the mitochondrial transport protein family, and on the PTP subunit/subunit contact site between transmembrane A helices, it is now suggested that the Ser158 site is at the PTP subunit/subunit contact site. Adenosine Diphosphate 66-69 solute carrier family 25 member 3 Bos taurus 186-189 15240102-5 2004 Based on the high resolution structure of a subunit of the bovine ADP/ATP translocase, on sequence similarities between members of the mitochondrial transport protein family, and on the PTP subunit/subunit contact site between transmembrane A helices, it is now suggested that the Ser158 site is at the PTP subunit/subunit contact site. Adenosine Diphosphate 66-69 solute carrier family 25 member 3 Bos taurus 303-306 33873776-5 2004 A second group of proteins unrelated to those above, the sirtuins (Sir2) and poly ADP-ribose polymerases (PARPs), cleave NAD and transfer the ADP-ribose group to acetyl groups and proteins, respectively. Adenosine Diphosphate 82-85 sirtuin 1 Homo sapiens 67-71 15238515-0 2004 Sal1p, a calcium-dependent carrier protein that suppresses an essential cellular function associated With the Aac2 isoform of ADP/ATP translocase in Saccharomyces cerevisiae. Adenosine Diphosphate 126-129 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 0-5 15238515-12 2004 On the basis of these observations, it is proposed that Aac2p and Sal1p may define two parallel pathways that transport a nucleotide substrate in an operational mode distinct from ADP/ATP exchange. Adenosine Diphosphate 180-183 Ca(2+)-binding ATP:ADP antiporter SAL1 Saccharomyces cerevisiae S288C 66-71 14983235-1 2004 CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1; E-NTPDase-1), is highly expressed on quiescent vascular endothelial cells and efficiently hydrolyzes extracellular ATP and ADP to AMP and ultimately adenosine. Adenosine Diphosphate 180-183 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 14983235-1 2004 CD39 (ecto-nucleoside triphosphate diphosphohydrolase-1; E-NTPDase-1), is highly expressed on quiescent vascular endothelial cells and efficiently hydrolyzes extracellular ATP and ADP to AMP and ultimately adenosine. Adenosine Diphosphate 180-183 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 6-55 14645230-1 2004 ATP-sensitive potassium (KATP) channels in neuron and neuroendocrine cells consist of a pore-forming Kir6.2 and regulatory sulfonylurea receptor (SUR1) subunits, which are regulated by ATP and ADP. Adenosine Diphosphate 193-196 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 101-107 14749375-7 2004 In addition, our data show that PARP activity regulates the DNA binding activity of TRF2 via both a covalent heteromodification of the dimerization domain of TRF2 and a noncovalent binding of poly(ADP-ribose) to the myb domain of TRF2. Adenosine Diphosphate 197-200 telomeric repeat binding factor 2 Homo sapiens 84-88 14736431-5 2004 RESULTS: After platelet activation with adenosine diphosphate, thrombin receptor-activating peptide, or U46-619, relative reductions in conformationally activated GP IIb/IIIa receptor expression (evaluated with PAC-1) of 48%, 43%, and 33%, respectively (all p < 0.0001), were seen with clopidogrel, but further 80%, 78%, and 72% (all p < 0.0001) reductions were seen with eptifibatide. Adenosine Diphosphate 40-61 integrin subunit alpha 2b Homo sapiens 163-169 14680631-14 2003 We show that the Srv2 complex is a large multimeric structure and functions as an intermediate in actin monomer processing, converting cofilin bound ADP-actin monomers to profilin bound ATP-actin monomers and recycling cofilin for new rounds of filament depolymerization. Adenosine Diphosphate 149-152 cofilin Saccharomyces cerevisiae S288C 135-142 14644449-0 2003 Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP. Adenosine Diphosphate 107-110 heat shock protein family H (Hsp110) member 1 Homo sapiens 0-6 14644449-2 2003 Here, we show that Hsp105alpha and Hsp105beta bind non-native protein through the beta-sheet domain and suppress the aggregation of heat-denatured protein in the presence of ADP rather than ATP. Adenosine Diphosphate 174-177 heat shock protein family H (Hsp110) member 1 Homo sapiens 19-30 14644449-2 2003 Here, we show that Hsp105alpha and Hsp105beta bind non-native protein through the beta-sheet domain and suppress the aggregation of heat-denatured protein in the presence of ADP rather than ATP. Adenosine Diphosphate 174-177 heat shock protein family H (Hsp110) member 1 Homo sapiens 35-45 14643202-3 2003 The resulting structure illustrates a head-to-tail packing arrangement of the two p97 AAA domains in a natural hexameric state with D1 ADP bound and D2 nucleotide free. Adenosine Diphosphate 135-138 valosin containing protein Mus musculus 82-85 14504133-3 2003 TRA-418 inhibited platelet GPIIb/IIIa activation as well as P-selectin expression induced by adenosine 5"-diphosphate, thrombin receptor agonist peptide 1-6 (Ser-Phe-Leu-Leu-Arg-Asn-NH2), and U-46619 in the presence of epinephrine (U-46619+ epinephrine). Adenosine Diphosphate 93-117 T cell receptor alpha locus Homo sapiens 0-3 12742085-4 2003 On the other hand, the GLUD2 isoform assumes in the absence of GTP a conformational state associated with little catalytic activity, but it remains amenable to full activation by ADP and/or L-leucine. Adenosine Diphosphate 179-182 glutamate dehydrogenase 2 Homo sapiens 23-28 12606624-1 2003 Excessive activation of poly(ADP-ribose) polymerase-1 (PARP-1), a nuclear enzyme catalyzing the transfer of ADP-ribose units from NAD to acceptor proteins, induces cellular energy failure by NAD and ATP depletion and has been proposed to play a causative role in a number of pathological conditions, including ischemia/reperfusion injury. Adenosine Diphosphate 29-32 poly (ADP-ribose) polymerase family, member 1 Mus musculus 55-61 12758082-0 2003 Regulation of RecA protein binding to DNA by opposing effects of ATP and ADP on inter-domain contacts: analysis by urea-induced unfolding of wild-type and C-terminal truncated RecA. Adenosine Diphosphate 73-76 RAD51 recombinase Homo sapiens 14-18 12758082-1 2003 RecA protein requires ATP and its hydrolysis to ADP to complete the DNA strand-exchange reaction. Adenosine Diphosphate 48-51 RAD51 recombinase Homo sapiens 0-4 12758082-8 2003 ATP and its unhydrolyzable analog (ATPgammaS), which enhance the binding of RecA to DNA, facilitated the urea-induced change in RecA tryptophan fluorescence, while ADP, an antagonist of ATP, prevented the change. Adenosine Diphosphate 164-167 RAD51 recombinase Homo sapiens 76-80 12765698-4 2003 Thus, stimulation of TRPM2 is likely to occur after activation of CD38 (producing ADP-ribose) and during the oxidative burst (enhancing the NAD concentration). Adenosine Diphosphate 82-85 transient receptor potential cation channel subfamily M member 2 Homo sapiens 21-26 12596269-0 2003 Hidden order in the GroEL-GroES-(ADP)7 chaperonin: forms, folding, and ADP-binding sites. Adenosine Diphosphate 33-36 heat shock protein family D (Hsp60) member 1 Homo sapiens 20-25 12940636-9 2003 The degree of inhibition by KAL was smaller when ADP was the agonist. Adenosine Diphosphate 49-52 kallikrein related peptidase 4 Homo sapiens 28-31 15906718-1 2003 Glucose-6-phosphate dehydrogenase (G6PD) is one of the enzymes needed by the erythrocyte to generate ATP from ADP. Adenosine Diphosphate 110-113 glucose-6-phosphate dehydrogenase Homo sapiens 0-33 15906718-1 2003 Glucose-6-phosphate dehydrogenase (G6PD) is one of the enzymes needed by the erythrocyte to generate ATP from ADP. Adenosine Diphosphate 110-113 glucose-6-phosphate dehydrogenase Homo sapiens 35-39 12486014-4 2002 The crystal structure of ParM with and without ADP demonstrates that it is a member of the actin family of proteins and shows a domain movement of 25 degrees upon nucleotide binding. Adenosine Diphosphate 47-50 plasmid segregation protein parM Escherichia coli 25-29 12356756-6 2002 BAP stimulated the ATPase activity of BiP when added alone or together with the ER DnaJ protein, ERdj4, by promoting the release of ADP from BiP. Adenosine Diphosphate 132-135 SIL1 nucleotide exchange factor Homo sapiens 0-3 12474075-4 2002 We chose to study the homomeric Kir6.2 channel with 36 amino acids deleted at the C-terminal end, as there are ADP/ATP-binding sites in the SUR subunit, which may obscure the understanding of the channel-gating process. Adenosine Diphosphate 111-114 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 32-38 12356871-3 2002 Binding of Hsp70-peptide complex to the exoplasmic domain of CD40 is mediated by the NH(2)-terminal nucleotide-binding domain of Hsp70 in its ADP state. Adenosine Diphosphate 142-145 heat shock protein family A (Hsp70) member 4 Homo sapiens 11-16 12356871-3 2002 Binding of Hsp70-peptide complex to the exoplasmic domain of CD40 is mediated by the NH(2)-terminal nucleotide-binding domain of Hsp70 in its ADP state. Adenosine Diphosphate 142-145 heat shock protein family A (Hsp70) member 4 Homo sapiens 129-134 12356871-5 2002 Binding of Hsp70-ADP to CD40 is strongly increased in the presence of Hsp70 peptide substrate, and induces signaling via p38. Adenosine Diphosphate 17-20 heat shock protein family A (Hsp70) member 4 Homo sapiens 11-16 12356871-5 2002 Binding of Hsp70-ADP to CD40 is strongly increased in the presence of Hsp70 peptide substrate, and induces signaling via p38. Adenosine Diphosphate 17-20 heat shock protein family A (Hsp70) member 4 Homo sapiens 70-75 12198249-7 2002 However, the stimulatory effects of 0.2 mM ADP on SUR1/Kir6.2 currents were reduced by 26.7 +/- 2.9% (P < 0.05) in the presence of cPKA. Adenosine Diphosphate 43-46 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 55-61 12198249-11 2002 The marked alteration of the PKA-mediated effects at different ADP levels may provide a cellular mechanism for the glucose-sensitivity of GLP-1. Adenosine Diphosphate 63-66 glucagon Rattus norvegicus 138-143 12147348-4 2002 However, product inhibition studies suggested that MAPKAPK2 follows an ordered bi-bi kinetic mechanism, where ATP must bind to the enzyme prior to the SRF-peptide and the phosphorylated product is released first, followed by ADP. Adenosine Diphosphate 225-228 MAPK activated protein kinase 2 Homo sapiens 51-59 12084815-7 2002 In platelets that had been activated by ADP and allowed to aggregate, EphA4 formed complexes with two tyrosine kinases, Fyn and Lyn, and the cell adhesion molecule, L1. Adenosine Diphosphate 40-43 EPH receptor A4 Homo sapiens 70-75 12096063-3 2002 To investigate whether muscle regulatory proteins, myosin light chain 2 (LC2) and troponin C (TnC), play a part in the MgADP-induced contraction, these proteins were partly extracted by treatment with trans-1,2-cyclohexanediamine-N,N,N",N"-tetraacetic acid (CDTA), a chelater of divalent cations, and the MgADP-tension relationship was examined in rabbit psoas and bovine cardiac skinned fibres. Adenosine Diphosphate 119-124 tenascin Oryctolagus cuniculus 82-92 12096063-3 2002 To investigate whether muscle regulatory proteins, myosin light chain 2 (LC2) and troponin C (TnC), play a part in the MgADP-induced contraction, these proteins were partly extracted by treatment with trans-1,2-cyclohexanediamine-N,N,N",N"-tetraacetic acid (CDTA), a chelater of divalent cations, and the MgADP-tension relationship was examined in rabbit psoas and bovine cardiac skinned fibres. Adenosine Diphosphate 119-124 tenascin Oryctolagus cuniculus 94-97 11867634-3 2002 Channels formed by co-transfection of Kir6.2 and the mutant SUR1 in COS cells have reduced response to MgADP ( approximately 10% that of the wild-type channels) and reduced surface expression ( approximately 19% that of the wild-type channels). Adenosine Diphosphate 103-108 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 38-44 11867639-8 2002 The differential effects of ATP and ADP on the competition between the inducer and Aes (or MalY) suggest that the ATPase activity displayed by MalT plays a role in the negative control of its activity. Adenosine Diphosphate 36-39 ATPase Escherichia coli 114-120 11839740-12 2002 Ammonium sulfate plus spermidine decreased the affinity of hRAD51 for ADP substantially ( approximately 10-fold) and ATP modestly ( approximately 3-fold). Adenosine Diphosphate 70-73 RAD51 recombinase Homo sapiens 59-65 11839741-4 2002 Here we have determined that ADP and ATP/ATPgammaS affect the DNA binding and aggregation properties of the human RecA homolog human RAD51 protein (hRAD51). Adenosine Diphosphate 29-32 RAD51 recombinase Homo sapiens 114-118 11839741-4 2002 Here we have determined that ADP and ATP/ATPgammaS affect the DNA binding and aggregation properties of the human RecA homolog human RAD51 protein (hRAD51). Adenosine Diphosphate 29-32 RAD51 recombinase Homo sapiens 133-138 11839741-4 2002 Here we have determined that ADP and ATP/ATPgammaS affect the DNA binding and aggregation properties of the human RecA homolog human RAD51 protein (hRAD51). Adenosine Diphosphate 29-32 RAD51 recombinase Homo sapiens 148-154 11839741-7 2002 Conversely, in the presence of ADP and ATP, the RecA ssDNA complex is unstable, while the hRAD51 ssDNA complex is stabilized. Adenosine Diphosphate 31-34 RAD51 recombinase Homo sapiens 48-52 11839741-7 2002 Conversely, in the presence of ADP and ATP, the RecA ssDNA complex is unstable, while the hRAD51 ssDNA complex is stabilized. Adenosine Diphosphate 31-34 RAD51 recombinase Homo sapiens 90-96 11839741-9 2002 The available evidence suggests that a low molecular weight hRAD51 small middle dotssDNA binding form (hRAD51 small middle dotssDNA(low)) correlates with active ADP and ATP processing. Adenosine Diphosphate 161-164 RAD51 recombinase Homo sapiens 60-66 11839741-9 2002 The available evidence suggests that a low molecular weight hRAD51 small middle dotssDNA binding form (hRAD51 small middle dotssDNA(low)) correlates with active ADP and ATP processing. Adenosine Diphosphate 161-164 RAD51 recombinase Homo sapiens 103-109 11839741-10 2002 A high molecular weight hRAD51 small middle dotssDNA aggregate (hRAD51 small middle dotssDNA(high)) appears to correlate with a form that fails to process ADP and ATP. Adenosine Diphosphate 155-158 RAD51 recombinase Homo sapiens 24-30 11839741-10 2002 A high molecular weight hRAD51 small middle dotssDNA aggregate (hRAD51 small middle dotssDNA(high)) appears to correlate with a form that fails to process ADP and ATP. Adenosine Diphosphate 155-158 RAD51 recombinase Homo sapiens 64-70 11944902-1 2002 The work presented here demonstrates that platelets from mice lacking LAT (linker for the activation of T cells) show reversible aggregation in response to concentrations of collagen that cause TxA2/ADP-dependent irreversible aggregation of control platelets. Adenosine Diphosphate 199-202 linker for activation of T cells Mus musculus 70-73 11944902-5 2002 Though the mechanism(s) of costimulatory signals by collagen, ADP, and TxA2 remains unidentified, it is clear that LAT plays a positive role in collagen-induced, TxA2/ADP-dependent aggregation, and a negative role in TxA2 or ADP-induced platelet aggregation. Adenosine Diphosphate 62-65 linker for activation of T cells Mus musculus 115-118 11944902-5 2002 Though the mechanism(s) of costimulatory signals by collagen, ADP, and TxA2 remains unidentified, it is clear that LAT plays a positive role in collagen-induced, TxA2/ADP-dependent aggregation, and a negative role in TxA2 or ADP-induced platelet aggregation. Adenosine Diphosphate 167-170 linker for activation of T cells Mus musculus 115-118 11944902-5 2002 Though the mechanism(s) of costimulatory signals by collagen, ADP, and TxA2 remains unidentified, it is clear that LAT plays a positive role in collagen-induced, TxA2/ADP-dependent aggregation, and a negative role in TxA2 or ADP-induced platelet aggregation. Adenosine Diphosphate 167-170 linker for activation of T cells Mus musculus 115-118 11909819-2 2002 The C-terminal 42 amino acid residues (C42) of SURs are responsible for ADP-induced differential activation of K(ATP) channels in SUR-subtypes. Adenosine Diphosphate 72-75 CDK5 regulatory subunit associated protein 1 Homo sapiens 39-42 11909819-3 2002 By examining ADP-effect on K(ATP) channels containing various chimeras of SUR2A and SUR2B, we identified a segment of 7 residues at central portion of C42 critical for this phenomenon. Adenosine Diphosphate 13-16 CDK5 regulatory subunit associated protein 1 Homo sapiens 151-154 11944027-7 2002 Antibodies known to inhibit fibrinogen binding to GPIIb/IIIa after adenosine diphosphate- and collagen- induced aggregation had very little effect on initial platelet adhesion. Adenosine Diphosphate 67-88 integrin subunit alpha 2b Homo sapiens 50-55 11827541-0 2002 Transmembrane domains confer different substrate specificities and adenosine diphosphate hydrolysis mechanisms on CD39, CD39L1, and chimeras. Adenosine Diphosphate 67-88 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 120-126 11827541-3 2002 Here we show that the extracellular domain of CD39L1 ecto-adenosine triphosphatase (ecto-ATPase) has the same 3:1 ATP:ADP hydrolysis ratio as the extracellular domain of CD39, suggesting that the transmembrane domains are required to confer the native substrate specificities on each enzyme. Adenosine Diphosphate 118-121 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 46-52 11827541-5 2002 However, H50G substitution diminishes both ATPase and ADPase activities of native CD39L1, in contrast to its selective effect on ATPase activity in CD39, suggesting that the transmembrane domains confer different ADP hydrolysis mechanisms on CD39 and CD39L1. Adenosine Diphosphate 54-57 ectonucleoside triphosphate diphosphohydrolase 2 Homo sapiens 82-88 11770867-7 2001 CD39 rapidly and preferentially metabolizes ADP released from activated platelets. Adenosine Diphosphate 44-47 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 0-4 11770867-8 2001 ADP is the final common pathway for platelet recruitment and thrombus formation, and platelet aggregation and recruitment are abolished by CD39. Adenosine Diphosphate 0-3 ectonucleoside triphosphate diphosphohydrolase 1 Mus musculus 139-143 11736627-13 2001 The conformational changes with the ATP synthase, including the vital change when bound ADP and Pi are converted to bound ATP, are correlated with those that occur in enzyme catalysis in general, as illustrated by recent studies of Rose with fumarase. Adenosine Diphosphate 88-91 fumarate hydratase Homo sapiens 242-250 11520817-2 2001 However, a marked and rapid externalization of GPIIb/IIIa was also observed upon stimulation with 30 microM adenosine diphosphate (ADP). Adenosine Diphosphate 108-129 integrin subunit alpha 2b Homo sapiens 47-52 11520817-2 2001 However, a marked and rapid externalization of GPIIb/IIIa was also observed upon stimulation with 30 microM adenosine diphosphate (ADP). Adenosine Diphosphate 131-134 integrin subunit alpha 2b Homo sapiens 47-52 11520817-3 2001 ADP-induced fibrinogen binding was completely inhibited by 10 microg/mL abciximab, 30 nM tirofiban, or 3 microg/mL eptifibatide, while fibrinogen binding induced by 100 microM TRAP was inhibited only by 50%. Adenosine Diphosphate 0-3 TRAP Homo sapiens 176-180 11511517-9 2001 Unlike the uncoupler CCCP, however, UCP3 raised the ATP/ADP ratio and modestly increased glucose uptake and glycolysis. Adenosine Diphosphate 56-59 uncoupling protein 3 Homo sapiens 36-40 11672475-0 2001 Activation of the alpha(2A)-adrenoceptor mediates deceleration of the deaggregation component of the response to ADP or 5-HT in human platelets in vitro. Adenosine Diphosphate 113-116 adrenoceptor alpha 2A Homo sapiens 18-40 11441021-3 2001 Bag-1M and a C-terminal fragment of it are potent nucleotide exchange factors as they stimulated the ADP dissociation rate of Hsc70 and Hsp70 up to 900-fold. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 8 Homo sapiens 126-131 11441021-3 2001 Bag-1M and a C-terminal fragment of it are potent nucleotide exchange factors as they stimulated the ADP dissociation rate of Hsc70 and Hsp70 up to 900-fold. Adenosine Diphosphate 101-104 heat shock protein family A (Hsp70) member 4 Homo sapiens 136-141 11710806-2 2001 It was confirmed by monitoring oxygen consumption by isolated rat liver mitochondria that, beginning from 5 microM, Cd2+ decreased both ADP and uncoupler-stimulated respiration and increased their basal respiration when succinate was used as respiratory substrate. Adenosine Diphosphate 136-139 Cd2 molecule Rattus norvegicus 116-119 11580260-4 2001 Both types of cooperativity are modulated by various heterotropic allosteric effectors, which include nonfolded proteins, ADP, Mg2+, monovalent ions such as K+, and cochaperonins in the case of type I chaperonins such as GroEL. Adenosine Diphosphate 122-125 heat shock protein family D (Hsp60) member 1 Homo sapiens 221-226 11447083-6 2001 Patients were classified into high and low platelet reactivity groups on the basis of extent of activation of GP IIb/IIIa in response to 0.2 micromol/L ADP. Adenosine Diphosphate 152-155 integrin subunit alpha 2b Homo sapiens 110-116 11401531-3 2001 We, therefore, examined the effect of ADP-ribosylation of CD38 in mouse pancreatic islet cells. Adenosine Diphosphate 38-41 CD38 antigen Mus musculus 58-62 11307824-6 2001 Finally, we provide evidence that secreted ADP, known to play a key role in TRAP-induced irreversible phase of aggregation, was involved in the sustained MLC phosphorylation through Rho-kinase and could be replaced by epinephrine. Adenosine Diphosphate 43-46 TRAP Homo sapiens 76-80 11170435-0 2001 Evidence for iterative ratcheting of receptor-bound hsp70 between its ATP and ADP conformations during assembly of glucocorticoid receptor.hsp90 heterocomplexes. Adenosine Diphosphate 78-81 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-57 11170435-6 2001 Here, we demonstrate that, during the priming step, ATP-bound hsp70 is converted to GR-bound hsp70 that is approximately 1/3 in the ADP- and approximately 2/3 in the ATP-dependent conformation. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 4 Homo sapiens 62-67 11170435-6 2001 Here, we demonstrate that, during the priming step, ATP-bound hsp70 is converted to GR-bound hsp70 that is approximately 1/3 in the ADP- and approximately 2/3 in the ATP-dependent conformation. Adenosine Diphosphate 132-135 heat shock protein family A (Hsp70) member 4 Homo sapiens 93-98 11170435-10 2001 This suggests that GR-bound hsp70 is also converted from the ATP-dependent to the ADP-dependent conformation while it cooperates with hsp90 to activate steroid binding activity. Adenosine Diphosphate 82-85 heat shock protein family A (Hsp70) member 4 Homo sapiens 28-33 11170435-11 2001 Because the priming step requires both sustained high levels of ATP and YDJ-1 for optimal activity and because both steps require potassium, we predict that receptor-bound hsp70 undergoes iterative ratcheting between its ATP- and ADP-dependent conformations in opening the hydrophobic steroid binding pocket. Adenosine Diphosphate 230-233 heat shock protein family A (Hsp70) member 4 Homo sapiens 172-177 11121020-3 2000 In the present study, the sensitivity of RFC to partial proteolysis is used to show that addition of ATP, ATPgammaS, or ADP induces different structural changes in RFC. Adenosine Diphosphate 120-123 replication factor C subunit 1 Homo sapiens 41-44 11121020-3 2000 In the present study, the sensitivity of RFC to partial proteolysis is used to show that addition of ATP, ATPgammaS, or ADP induces different structural changes in RFC. Adenosine Diphosphate 120-123 replication factor C subunit 1 Homo sapiens 164-167 11202610-10 2000 These findings suggest that 1) SNC inhibits translocation of vesicles containing synaptophysin and SNAP-25, and 2) SNC reacts with cysteine residues in Gi/Go, causing inhibition of ADP-ribosylation by pertussis toxin. Adenosine Diphosphate 181-184 synaptophysin Rattus norvegicus 81-94 10969013-16 2000 This presents technical problems in analyzing and interpreting the kinetics of myosin V and likely of other members of the myosin family with high ADP affinities. Adenosine Diphosphate 147-150 myosin VA Homo sapiens 79-87 10962016-12 2000 With Kir6.2-GFP+SUR1, slow rundown also caused loss of MgADP stimulation and sulfonylurea inhibition, suggesting functional uncoupling of SUR1 from Kir6.2-GFP. Adenosine Diphosphate 55-60 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 5-11 10962016-12 2000 With Kir6.2-GFP+SUR1, slow rundown also caused loss of MgADP stimulation and sulfonylurea inhibition, suggesting functional uncoupling of SUR1 from Kir6.2-GFP. Adenosine Diphosphate 55-60 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 148-154 10962016-16 2000 In summary, short-term regulation of Kir6.2+SUR1 channels involves MgADP, while long-term regulation requires PIP(2) and phosphorylation. Adenosine Diphosphate 67-72 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 37-43 10958667-1 2000 Poly(ADP-ribose) polymerase (PARP) is a DNA binding zinc finger protein that catalyzes the transfer of ADP-ribose residues from NAD(+) to itself and different chromatin constituents, forming branched ADP-ribose polymers. Adenosine Diphosphate 5-8 poly (ADP-ribose) polymerase family, member 1 Mus musculus 29-33 10864508-4 2000 Furthermore, for the alpha-only thermosome, the steady-state ATPase rate is determined by the cleavage reaction itself, whereas, for the alphabeta-thermosome, the rate-limiting step is associated with a post-hydrolysis isomerisation into a non-covalent ADP*P(i) species prior to the release of the gamma-phosphate group. Adenosine Diphosphate 253-256 ATPase Escherichia coli 61-67 10764743-9 2000 We predict that hsp70 in its ATP-dependent conformation binds initially to the folded receptor and is then converted to the ADP-dependent form with high affinity for hydrophobic substrate. Adenosine Diphosphate 124-127 heat shock protein family A (Hsp70) member 4 Homo sapiens 16-21 10896249-5 2000 We found that inhibition of aggregation and GPIIb-IIIa blockade of ADP-stimulated platelets was almost complete during abciximab administration. Adenosine Diphosphate 67-70 integrin subunit alpha 2b Homo sapiens 44-49 10813386-2 2000 Pretreatment with C3 exoenzyme of Clostridium botulinum, which selectively inactivates rho p21 by adenosine diphosphate (ADP) ribosylation, resulted in a significant inhibition of ET-1-induced Ca2+ sensitization, but had no effect on carbachol-induced Ca2+ sensitization. Adenosine Diphosphate 98-119 endothelin-1 Oryctolagus cuniculus 180-184 10742300-12 2000 CS-747 also exhibited a marked inhibition of ADP-induced ex vivo platelet aggregation in PRP with a rapid onset (<0.5 h) and long duration (>3 days) of action (ED(50) at 4 h=1.2 mg kg(-1)). Adenosine Diphosphate 45-48 proline rich protein 2-like 1 Rattus norvegicus 89-92 10741635-11 2000 Aspirin and clopidogrel reinforced effects of the GPIIb/IIIa inhibitors on adenosine diphosphate (5 micromol/L)-induced aggregation in an additive manner, a supra-additive effect was observed with collagen (2 microg x mL(-1))-induced aggregation. Adenosine Diphosphate 75-96 integrin subunit alpha 2b Homo sapiens 50-55 10887949-3 2000 In an in vitro human platelet aggregation assay, the IC50 values (microM) of NSP-513 for platelet aggregation induced by collagen, U-46619, arachidonic acid, adenosine diphosphate (ADP), epinephrine and thrombin were 0.31, 0.25, 0.082, 0.66, 0.23 and 0.73, respectively. Adenosine Diphosphate 158-179 sperm antigen with calponin homology and coiled-coil domains 1 Homo sapiens 77-80 10887949-3 2000 In an in vitro human platelet aggregation assay, the IC50 values (microM) of NSP-513 for platelet aggregation induced by collagen, U-46619, arachidonic acid, adenosine diphosphate (ADP), epinephrine and thrombin were 0.31, 0.25, 0.082, 0.66, 0.23 and 0.73, respectively. Adenosine Diphosphate 181-184 sperm antigen with calponin homology and coiled-coil domains 1 Homo sapiens 77-80 10581363-6 1999 In this article, we present a model in which the activity of the K(ATP) channel is determined by the balance of the action of ADP, which activates the channel through SUR1, and the action of ATP, which stabilizes the long closed state by binding to Kir6.2. Adenosine Diphosphate 126-129 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 249-255 10657530-6 1999 The marked effect of the non-hydrolysable adenosine nucleotide App(NH)p also supports a cAMP-dependent TyrOH activation not related to ADP or an ADP-dependent mechanism. Adenosine Diphosphate 135-138 amyloid beta precursor protein Rattus norvegicus 63-71 10657530-6 1999 The marked effect of the non-hydrolysable adenosine nucleotide App(NH)p also supports a cAMP-dependent TyrOH activation not related to ADP or an ADP-dependent mechanism. Adenosine Diphosphate 145-148 amyloid beta precursor protein Rattus norvegicus 63-71 10517700-4 1999 The permanent ektopic expression of hDAT in HEK-293 cells confers time and dose-dependent cytotoxicity at nanomolar concentrations of MPP+ with an IC50 value of 740 nM after 48 h. MPP+ initially induces a fast increase of cellular NADH content within the first 6 h, followed by a slow reduction of intracellular ATP (IC50 value of 690 nM after 48 h) as well as reduction of intracellular ATP/ADP ratio. Adenosine Diphosphate 392-395 solute carrier family 6 member 3 Homo sapiens 36-40 10517851-10 1999 AMP, ADP, and ATP inhibited the activity of SSADH (Ki = 2.5-8 mM). Adenosine Diphosphate 5-8 aldehyde dehydrogenase 5 family member A1 Homo sapiens 44-49 10544919-2 1999 In vitro effects of the GPIIb/IIIa antagonist fradafiban on ADP-induced platelet aggregation were determined using WBSPC and PRP turbidimetry, comparing citrate and hirudin anticoagulation. Adenosine Diphosphate 60-63 integrin subunit alpha 2b Homo sapiens 24-29 11721406-6 1999 CONCLUSION: The anti-CD9 McAbs, HI117 and SJ9A4, can reversibly expose platelet Fg receptors, probably via three signaling pathways, i.e. thromboxane, secreted ADP and cAMP, protein kinase C (PKC) activation presumably being the common passage for the signaling. Adenosine Diphosphate 160-163 CD9 molecule Homo sapiens 21-24 10409709-4 1999 The activity was equally high toward ADP/ATP, GDP/GTP, and UDP/UTP and approximately 50% less toward CDP/CTP and thiamine pyrophosphate, but there was no activity toward GMP, indicating that the Ynd1 protein belongs to the apyrase family. Adenosine Diphosphate 37-40 apyrase Saccharomyces cerevisiae S288C 195-199 10381504-9 1999 Adenosine diphosphate caused a modest Ca2+-dependent stimulation of DNA synthesis in the absence of cytokines and specifically enhanced the effect of SCF. Adenosine Diphosphate 0-21 KIT ligand Homo sapiens 150-153 10199405-2 1999 We report here the crystal structures of a 40 kDa ATPase fragment of E. coli MutL (LN40) complexed with a substrate analog, ADPnP, and with product ADP. Adenosine Diphosphate 124-127 ATPase Escherichia coli 50-56 10204114-6 1999 The single-channel conductance of the homomeric KIR6.2 channels is equivalent to SUR/KIR6.2 channels, but they differ in all other respects, including bursting behavior, pharmacological properties, sensitivity to ATP and ADP, and trafficking to the plasma membrane. Adenosine Diphosphate 221-224 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 48-54 9804829-3 1998 The purified C. lectularius apyrase was an acidic protein with a pI of 5.1 and molecular mass of approximately 40 kDa that inhibited ADP-induced platelet aggregation and hydrolyzed platelet agonist ADP with specific activity of 379 units/mg protein. Adenosine Diphosphate 133-136 apyrase Cimex lectularius 28-35 9804829-3 1998 The purified C. lectularius apyrase was an acidic protein with a pI of 5.1 and molecular mass of approximately 40 kDa that inhibited ADP-induced platelet aggregation and hydrolyzed platelet agonist ADP with specific activity of 379 units/mg protein. Adenosine Diphosphate 198-201 apyrase Cimex lectularius 28-35 9684361-11 1998 The tomato fruit glucokinase was sensitive to product inhibition by ADP (Ki = 36 microM). Adenosine Diphosphate 68-71 glucokinase Homo sapiens 17-28 9718865-4 1998 RESULTS: ADP, GRGDS, PAF, U46619 and collagen were able to induce rapid Ca++ transients in CPA-47 endothelial cells and the response was stable after repeated additions, while thrombin acted slightly differently, as cells became refractory to this agonist after the first response, but they remained sensitive to the other inducers. Adenosine Diphosphate 9-12 coagulation factor II, thrombin Bos taurus 176-184 9618467-1 1998 For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --> ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system. Adenosine Diphosphate 197-200 myosin, heavy chain 10, non-muscle Gallus gallus 75-81 9618467-1 1998 For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --> ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system. Adenosine Diphosphate 197-200 myosin, heavy chain 10, non-muscle Gallus gallus 170-176 9618467-1 1998 For analyzing the mechanism of energy transduction in the "motor" protein, myosin, it is opportune both to model the structural change in the hydrolytic transition, ATP (myosin-bound) + H2O --> ADP.Pi (myosin-bound) and to check the plausibility of the model by appropriate site-directed mutations in the functional system. Adenosine Diphosphate 197-200 myosin, heavy chain 10, non-muscle Gallus gallus 170-176 9578546-6 1998 The postpower stroke heads (rigor.ADP/Ca2+ and rigor/Ca2+) induced further changes in the orientational distribution of labeled domain of TnC irrespective of the degree of cooperativity in thin filaments. Adenosine Diphosphate 34-37 tenascin C Homo sapiens 138-141 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 49-52 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 134-139 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 134-139 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 134-139 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9571049-4 1998 This non-competitive inhibition of the ATPase by ADP is consistent with a ring-switching, or "two-stroke", mechanism of the type: ATP:GroEL --> ADP:GroEL --> ADP:GroEL:ATP --> GroEL:ATP --> GroEL:ADP, i.e. with respect to the GroEL rings, ATP turns over in an alternating fashion. Adenosine Diphosphate 147-150 heat shock protein family D (Hsp60) member 1 Homo sapiens 151-156 9556521-8 1998 Interestingly, the more physiologically relevant "low affinity" nucleotide-bound ((ATP/ADP) GroEL--GroES) complex is not as efficient at capturing the initial folding intermediates of glutamine synthetase. Adenosine Diphosphate 87-90 chaperonin GroES Escherichia coli 99-104 9547364-5 1998 Solutions prepared from commercially available 2-methylthio-ATP (2-MeSATP) or 2-chloro-ATP (2-ClATP) contained approximately 10% of ADP derivatives. Adenosine Diphosphate 132-135 ATP citrate lyase Homo sapiens 94-99 9547364-7 1998 Purified 2-MeSATP and 2-ClATP antagonized platelet aggregation induced by ADP. Adenosine Diphosphate 74-77 ATP citrate lyase Homo sapiens 24-29 9488662-0 1998 Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone, Hsp70. Adenosine Diphosphate 10-13 heat shock protein family A (Hsp70) member 4 Homo sapiens 84-89 9488662-2 1998 We show here that, in addition to ATPase activity, purified Hsp70 free from nucleoside-diphosphate (NDP) kinase exhibits intrinsic ADP-ATP exchange activity. Adenosine Diphosphate 131-134 heat shock protein family A (Hsp70) member 4 Homo sapiens 60-65 9563821-4 1998 BAG-1 acts as a nucleotide exchange factor in the Hsc70 ATPase cycle, thereby competing with the cofactor Hip which stabilizes the ADP-bound state of Hsc70. Adenosine Diphosphate 131-134 heat shock protein family A (Hsp70) member 8 Homo sapiens 150-155 9462579-6 1998 Furthermore, patients with stable CAD formed more monocyte-platelet aggregates than did control subjects when their whole blood was stimulated with 1 micromol/liter of ADP (50.4 +/- 4.5 vs. 28.1 +/- 5.3, p < 0.01), 1 micromol/liter of ADP/epinephrine (60.7 +/- 4.3 vs. 48.0 +/- 4.8, p < 0.05) or 5 micromol/liter of TRAP (67.6 +/- 5.7 vs. 34.3 +/- 7.0, p < 0.01). Adenosine Diphosphate 168-171 TRAP Homo sapiens 322-326 9459569-3 1998 5-HT amplified, ADP-induced aggregation of rabbit platelets (5-HT2A) was inhibited by gamma-mangostin (IC50 = 0.29 microM), whereas that induced by thrombin was not affected, nor did gamma-mangostin affect 5-HT-induced contraction of the guinea-pig ileum (5-HT3)in the presence of 5-HT1, 5-HT2 and 5-HT4 receptor antagonists. Adenosine Diphosphate 16-19 prothrombin Oryctolagus cuniculus 148-156 9405475-8 1997 ADP also restored both pp72(syk) and pleckstrin phosphorylation of jararhagin-treated platelets in response to collagen, presumably via interaction of collagen with ADP-activated alphaIIbbeta3 integrin. Adenosine Diphosphate 0-3 spleen associated tyrosine kinase Homo sapiens 28-31 9365817-5 1997 Natriuretic peptides, however, affected the overflow of ADP and AMP to a lesser extent than ATP, resulting in an ATP:ADP ratio of 2:1 after rANF and of 1.5:1 after pBNP. Adenosine Diphosphate 117-120 natriuretic peptide A Rattus norvegicus 140-144 9300321-3 1997 In this study, SR 121566 exhibited a potent dose-dependent inhibition of adenosine diphosphate (ADP)-induced aggregation of rabbit platelets in vitro [median inhibitory concentration (IC50), 0.8 +/- 0.04 microM], whereas the GP IIb/IIIa antagonists SC 52012A and GR 144053F were devoid of antiplatelet activity. Adenosine Diphosphate 73-94 integrin alpha-IIb Oryctolagus cuniculus 225-231 9300321-3 1997 In this study, SR 121566 exhibited a potent dose-dependent inhibition of adenosine diphosphate (ADP)-induced aggregation of rabbit platelets in vitro [median inhibitory concentration (IC50), 0.8 +/- 0.04 microM], whereas the GP IIb/IIIa antagonists SC 52012A and GR 144053F were devoid of antiplatelet activity. Adenosine Diphosphate 96-99 integrin alpha-IIb Oryctolagus cuniculus 225-231 9285585-4 1997 The structure of the GroEL-GroES-(ADP)7 complex reveals how large en bloc movements of the cis ring"s intermediate and apical domains enable bound GroES to stabilize a folding chamber with ADP confined to the cis ring. Adenosine Diphosphate 34-37 chaperonin GroES Escherichia coli 27-32 9285585-4 1997 The structure of the GroEL-GroES-(ADP)7 complex reveals how large en bloc movements of the cis ring"s intermediate and apical domains enable bound GroES to stabilize a folding chamber with ADP confined to the cis ring. Adenosine Diphosphate 34-37 chaperonin GroES Escherichia coli 147-152 9285593-3 1997 We show here, however, that for the folding of malate dehydrogenase and Rubisco there is also an absolute requirement for ATP in the cis ring, as ADP and AMP-PNP are unable to promote folding. Adenosine Diphosphate 146-149 malic enzyme 1 Homo sapiens 47-67 9251811-12 1997 MgADP, for both S1(elc, rlc) and S1(elc). Adenosine Diphosphate 0-5 integrin subunit alpha 9 Homo sapiens 24-27 9136876-6 1997 In the presence of ADP or ATP analogues such as ATP-gamma-S or AMP-PNP, the affinity to bind GroES increases by at least 2 orders of magnitude depending on the nucleotide concentration. Adenosine Diphosphate 19-22 chaperonin GroES Escherichia coli 93-98 9048947-3 1997 The release of both ATP and ADP from Ssc1 was stimulated in the presence of Mge1, therefore we conclude that Mge1 functions as a nucleotide release factor for Ssc1. Adenosine Diphosphate 28-31 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae S288C 37-41 9048947-3 1997 The release of both ATP and ADP from Ssc1 was stimulated in the presence of Mge1, therefore we conclude that Mge1 functions as a nucleotide release factor for Ssc1. Adenosine Diphosphate 28-31 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae S288C 159-163 9048947-5 1997 ADP was much less effective in releasing Mge1 from Ssc1 whereas ATP gamma S and AMPPNP could not disrupt the Ssc1/Mge1 complex. Adenosine Diphosphate 0-3 Hsp70 family ATPase SSC1 Saccharomyces cerevisiae S288C 51-55 9087913-6 1997 These changes are also observed when GroEL is incubated with ADP and Pi, but not with ADP, which suggests that upon ATP binding, GroEL undergoes a conformational change that is partly maintained after ATP hydrolysis and as long as ADP and Pi are bound to the GroEL ring. Adenosine Diphosphate 61-64 heat shock protein family D (Hsp60) member 1 Homo sapiens 37-42 9087913-6 1997 These changes are also observed when GroEL is incubated with ADP and Pi, but not with ADP, which suggests that upon ATP binding, GroEL undergoes a conformational change that is partly maintained after ATP hydrolysis and as long as ADP and Pi are bound to the GroEL ring. Adenosine Diphosphate 61-64 heat shock protein family D (Hsp60) member 1 Homo sapiens 129-134 9087913-6 1997 These changes are also observed when GroEL is incubated with ADP and Pi, but not with ADP, which suggests that upon ATP binding, GroEL undergoes a conformational change that is partly maintained after ATP hydrolysis and as long as ADP and Pi are bound to the GroEL ring. Adenosine Diphosphate 61-64 heat shock protein family D (Hsp60) member 1 Homo sapiens 129-134 9323459-1 1997 Creatine kinases (CK) catalyze the reversible transfer of a high energy phosphate group between creatine phosphate and ADP to regenerate ATP in cell types where the requirements for ATP are extensive and/or sudden. Adenosine Diphosphate 119-122 creatine kinase B Rattus norvegicus 18-20 8996188-3 1997 It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 microM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. Adenosine Diphosphate 203-206 PCNA clamp associated factor Rattus norvegicus 32-35 9000123-3 1997 Similarly, when platelet aggregation was evaluated on PRP obtained from rats four hours after endotoxin administration, we found that platelet response to both ADP and collagen was significantly reduced. Adenosine Diphosphate 160-163 proline rich protein 2-like 1 Rattus norvegicus 54-57 8947033-3 1996 We find that GroEL-bound substrate polypeptide can induce GroES cycling on and off GroEL in the presence of ADP. Adenosine Diphosphate 108-111 heat shock protein family D (Hsp60) member 1 Homo sapiens 13-18 8947033-3 1996 We find that GroEL-bound substrate polypeptide can induce GroES cycling on and off GroEL in the presence of ADP. Adenosine Diphosphate 108-111 heat shock protein family D (Hsp60) member 1 Homo sapiens 83-88 8910414-9 1996 The substrate inhibition was not competitive with MgATP and could be attributed to formation of the abortive complex guanylate kinase.MgADP.GMP. Adenosine Diphosphate 134-139 guanylate kinase Saccharomyces cerevisiae S288C 117-133 8918457-5 1996 Mge1p is then required for the dissociation of the ADP form of mt-Hsp70 from Tim44 after release of inorganic phosphate but before release of ADP. Adenosine Diphosphate 51-54 protein translocase subunit TIM44 Saccharomyces cerevisiae S288C 77-82 8774724-0 1996 Transcription of the AAC1 gene encoding an isoform of mitochondrial ADP/ATP carrier in Saccharomyces cerevisiae is regulated by oxygen in a heme-independent manner. Adenosine Diphosphate 68-71 ADP/ATP carrier protein AAC1 Saccharomyces cerevisiae S288C 21-25 8856476-0 1996 Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP. Adenosine Diphosphate 145-148 5'-nucleotidase, cytosolic II Homo sapiens 46-49 8856476-10 1996 These findings suggest that cyclic AMP and cyclic GMP differentially modify the size of aggregates formed during epinephrine or ADP activation. Adenosine Diphosphate 128-131 5'-nucleotidase, cytosolic II Homo sapiens 50-53 8767925-6 1996 It is released under basal conditions and in response to mechanical stimuli such as shear stress and in response to receptor-operated agonists such as bradykinin, serotonin, ADP/ATP, thrombin, histamine and substance P. NO is the mediator of endothelium-dependent relaxation in the circulation and exerts its effects by activating soluble guanylyl cyclase in vascular smooth muscle, which in turn leads to the formation of cyclic guanosine monophosphate (cyclic GMP) and to relaxation. Adenosine Diphosphate 174-177 5'-nucleotidase, cytosolic II Homo sapiens 462-465 8832488-10 1996 Except for dipyridamole, all the drugs inhibited ex-vivo ADP-induced aggregation in PRP. Adenosine Diphosphate 57-60 proline rich protein 2-like 1 Rattus norvegicus 84-87 8626558-7 1996 In contrast, Hsc70 strongly bound ATP and ADP, specifically cross-linked with azido-ATP, and exhibited major shifts in fluorescence upon addition of ATP. Adenosine Diphosphate 42-45 heat shock protein family A (Hsp70) member 8 Homo sapiens 13-18 8743191-5 1996 Platelet aggregation in platelet rich plasma (PRP) samples was induced by adding ADP (2 x 10(-4)M) and measured in a turbidometric aggregometer. Adenosine Diphosphate 81-84 proline rich protein 2-like 1 Rattus norvegicus 46-49 8743194-11 1996 These results suggest that p72syk activation lies upstream of protein tyrosine phosphorylation, Ca2+ mobilization, ADP release, thromboxane A2 production and aggregation. Adenosine Diphosphate 115-118 spleen associated tyrosine kinase Homo sapiens 27-33 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 105-126 integrin subunit alpha 2b Homo sapiens 52-57 8608226-7 1996 Binding of MoAb PAC1, which binds to only activated GPIIb-IIIa, was diminished upon activation with PAF, adenosine diphosphate (ADP), thrombin receptor agonist peptide (SFLLRN), A23187, and 1,2-dioctonylglycerol (DiC8). Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 52-57 8564538-1 1996 Extensive three-dimensional structural resemblances between biotin carboxylase and the ADP-forming peptide synthetases, represented by glutathione synthetase and D-Ala:D-Ala ligase, reveal a previously unsuspected evolutionary relationship between two major families of ADP-forming ligases. Adenosine Diphosphate 87-90 methylcrotonyl-CoA carboxylase subunit 2 Homo sapiens 60-78 8750931-5 1996 The effect of PMA on the cholera toxin-catalysed ADP ribosylation was inhibited by the PKC inhibitor, H-7 (1-(5-isoquinolinesulfonyl)-2-methyl piperazine dihydrochloride). Adenosine Diphosphate 49-52 protein kinase C, gamma Rattus norvegicus 87-90 7499369-0 1995 The chaperonin GroEL is destabilized by binding of ADP. Adenosine Diphosphate 51-54 heat shock protein family D (Hsp60) member 1 Homo sapiens 15-20 7499369-4 1995 Binding of ADP results in destabilization of the GroEL oligomeric structure, and complete dissociation of the 14-mer in the presence of 5 mM ADP occurs at about 2 M urea with the midpoint of the transition at approximately 1 M urea. Adenosine Diphosphate 11-14 heat shock protein family D (Hsp60) member 1 Homo sapiens 49-54 7499369-7 1995 The ADP-bound form of the protein demonstrated increased hydrophobic exposure at lower urea concentrations than the uncomplexed GroEL. Adenosine Diphosphate 4-7 heat shock protein family D (Hsp60) member 1 Homo sapiens 128-133 7499369-8 1995 In addition, the GroEL-ADP complex is more accessible for proteolytic digestion by chymotrypsin than the uncomplexed protein, consistent with a more open, flexible form of the protein. Adenosine Diphosphate 23-26 heat shock protein family D (Hsp60) member 1 Homo sapiens 17-22 7670112-4 1995 Cell-free studies of the adenosine diphosphate-ribosylating activity of DT390 mGM-CSF showed results that were similar to those of native DT. Adenosine Diphosphate 25-46 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 78-85 7642301-12 1995 This differs from ADP-induced platelet aggregation, which relies on an intact platelet GP IIb/IIIa receptor with an accessible RGD sequence and dodecapeptide recognition site for fibrinogen. Adenosine Diphosphate 18-21 integrin alpha-IIb Oryctolagus cuniculus 87-93 7559755-4 1995 The identical effects were caused by injection of ADP-ribosylated recombinant RhoA into oocytes. Adenosine Diphosphate 50-53 ras homolog family member A L homeolog Xenopus laevis 78-82 7662666-5 1995 Previous studies showed that RecA protein will dissociate from dsDNA when ADP levels build up, or transfer from dsDNA to ssDNA when the latter is not bound by SSB. Adenosine Diphosphate 74-77 RAD51 recombinase Homo sapiens 29-33 7795224-6 1995 Subthreshold concentrations of Sph-1-P and weak platelet agonists such as adenosine diphosphate (ADP) and epinephrine synergistically elicited aggregation, which may be important for efficient amplification of platelet activation. Adenosine Diphosphate 74-95 ankyrin 1 Homo sapiens 31-36 7795224-6 1995 Subthreshold concentrations of Sph-1-P and weak platelet agonists such as adenosine diphosphate (ADP) and epinephrine synergistically elicited aggregation, which may be important for efficient amplification of platelet activation. Adenosine Diphosphate 97-100 ankyrin 1 Homo sapiens 31-36 7789507-1 1995 In the presence of MgATP or MgADP the E. coli chaperonin proteins, GroEL and GroES, form a stable asymmetric complex with a stoichiometry of two GroEL7:one GroES7: seven MgADP. Adenosine Diphosphate 28-33 chaperonin GroES Escherichia coli 77-82 7789507-3 1995 On the basis of cross-linking experiments with 8-azido-ATP and the heterobifunctional reagent, N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP), it was suggested that GroES and MgADP are bound to the same GroEL ring which resists proteinase K digestion [Nature 366 (1993) 228-233]. Adenosine Diphosphate 181-186 chaperonin GroES Escherichia coli 171-176 7776367-3 1995 DnaK ATPase was stimulated by substrates (ninefold) and DnaJ (13-fold) through stimulation of the rate limiting step, gamma-phosphate cleavage (approximately tenfold slower than ADP release). Adenosine Diphosphate 178-181 ATPase Escherichia coli 5-11 8935187-9 1995 Epinephrine and ADP induced aggregation was inhibited in concentrations higher than 30 micrograms/ml PRP. Adenosine Diphosphate 16-19 proline rich protein 2-like 1 Rattus norvegicus 101-104 7766894-5 1995 The RGA1 protein contains all the consensus regions of G protein alpha subunits except the cysteine residue near the C-terminus for ADP-ribosylation by pertussis toxin. Adenosine Diphosphate 132-135 GRAS family transcription factor family protein Arabidopsis thaliana 4-8 7766894-6 1995 The RGA1 polypeptide expressed in Escherichia coli was, however, ADP-ribosylated by 10 microM [adenylate-32P] NAD and activated cholera toxin. Adenosine Diphosphate 65-68 GRAS family transcription factor family protein Arabidopsis thaliana 4-8 7532398-6 1995 The autophosphorylation of PC-1 was inhibited by addition of histone IIa, and it was blocked by phosphodiesterase-I inhibitors (acidic fibroblast growth factor, dithiothreitol), by nucleotides (ATP, ADP, AMP), and by vanadate. Adenosine Diphosphate 199-202 ectonucleotide pyrophosphatase/phosphodiesterase 1 Rattus norvegicus 27-31 7836457-8 1995 The equilibrium binding of ADP or ATP to Hsc70 is unperturbed when K+ is replaced with Na+. Adenosine Diphosphate 27-30 heat shock protein family A (Hsp70) member 8 Homo sapiens 41-46 7840907-3 1994 Upon chemical modification of GroEL with N-ethylmaleimide, protease treatment in the presence of ATP or ADP generates GroEL fragments of 15 kDa (N15; residues 1-141) and 40 kDa (C40; residues 153-531). Adenosine Diphosphate 104-107 heat shock protein family D (Hsp60) member 1 Homo sapiens 30-35 7840907-3 1994 Upon chemical modification of GroEL with N-ethylmaleimide, protease treatment in the presence of ATP or ADP generates GroEL fragments of 15 kDa (N15; residues 1-141) and 40 kDa (C40; residues 153-531). Adenosine Diphosphate 104-107 heat shock protein family D (Hsp60) member 1 Homo sapiens 118-123 7520441-3 1994 The presence of the c-Kit receptor was demonstrated by the specific binding of 125I-KL/SCF to ADP-stimulated platelets. Adenosine Diphosphate 94-97 KIT ligand Homo sapiens 84-86 7520441-3 1994 The presence of the c-Kit receptor was demonstrated by the specific binding of 125I-KL/SCF to ADP-stimulated platelets. Adenosine Diphosphate 94-97 KIT ligand Homo sapiens 87-90 7520441-7 1994 We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF. Adenosine Diphosphate 114-117 KIT ligand Homo sapiens 178-180 7520441-7 1994 We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF. Adenosine Diphosphate 114-117 KIT ligand Homo sapiens 181-184 7520441-8 1994 The effect of KL/SCF on epinephrine/ADP-induced platelet activation appeared to be mediated in part through the thromboxane pathway. Adenosine Diphosphate 36-39 KIT ligand Homo sapiens 14-20 8051492-1 1994 Platelet membrane glycoproteins Ib (GPIb) and IIb/IIIa (GPIIb/IIIa) bind soluble von Willebrand factor (vWf) after stimulation with ristocetin (GPIb) or with thrombin or ADP (GPIIb/IIIa). Adenosine Diphosphate 170-173 integrin subunit alpha 2b Homo sapiens 56-61 8206959-6 1994 The approximate equality of the ADP release rate and the steady state ATPase rate indicates that ADP release is the rate-limiting step in ATP hydrolysis in the absence of microtubules. Adenosine Diphosphate 97-100 ATPase Escherichia coli 70-76 7911090-1 1994 In the presence of ADP, the molecular chaperones GroEL and GroES from Escherichia coli not only facilitated the refolding of various proteins, but also prevented their irreversible heat inactivation in vitro. Adenosine Diphosphate 19-22 chaperonin GroES Escherichia coli 59-64 7909810-0 1994 The effect of groES on the groEL-dependent assembly of dodecameric glutamine synthetase in the presence of ATP and ADP. Adenosine Diphosphate 115-118 chaperonin GroES Escherichia coli 14-19 7909810-10 1994 In addition, groES can initiate renaturation of GS from the groEL.GS arrested complex in the presence of ADP. Adenosine Diphosphate 105-108 chaperonin GroES Escherichia coli 13-18 8132511-5 1994 The fluorescence of Trp-163 is modestly quenched by the binding of ADP (21%) and strongly quenched by the nonhydrolyzable ATP analog, ATP gamma S (70%); since ADP and ATP gamma S stabilize the closed and open conformations of the recA-ssDNA complex, respectively, the quenched states observed with these nucleotides likely reflect differences in the fluorescence properties of tryptophan 163 in these two states. Adenosine Diphosphate 159-162 RAD51 recombinase Homo sapiens 230-234 8132511-7 1994 When ATP is added to [H163W]recA-ssDNA complexes, there is an immediate quenching of Trp-163 fluorescence (44%) which is intermediate in intensity between that observed with ADP and ATP gamma S. The ATP-induced quenching gradually decreases with time as the pool of ATP is converted to ADP by the ATP hydrolysis activity of the [H163W]recA protein. Adenosine Diphosphate 174-177 RAD51 recombinase Homo sapiens 28-32 8063195-5 1994 Furthermore, although mitochondrial transcription was sensitive to 4-hydroxynonenal, it was resistant to malondialdehyde as well as high levels of lipid peroxidation induced by ADP/Fe/NADPH. Adenosine Diphosphate 177-180 2,4-dienoyl-CoA reductase 1 Homo sapiens 184-189 8302589-2 1994 This HGF-induced cell motility was inhibited by microinjection of either rho GDI, an inhibitory GDP/GTP exchange protein for rho p21 small GTP-binding protein, or a botulinum exoenzyme C3 which is known to selectively impair the function of rho p21 by ADP-ribosylating its effector domain. Adenosine Diphosphate 252-255 hepatocyte growth factor Mus musculus 5-8 8241506-5 1993 Platelet exposure to adenosine diphosphate or thrombin, but not A23187 or chymotrypsin, markedly enhanced GPIIb and GPIIIa recovery relative to that observed with unstimulated platelets, or prostaglandin E1-treated platelets. Adenosine Diphosphate 21-42 integrin subunit alpha 2b Homo sapiens 106-111 8239651-10 1993 Because actin"s structure is maintained by a noncovalently bound adenine nucleotide (ATP or ADP), exposure to ATP/ADPases found in plasma and on cell membranes might also result in its denaturation. Adenosine Diphosphate 92-95 actin-66 Solanum tuberosum 8-13 8238012-5 1993 Activation-dependent receptor function of the GP IIb-IIIa complex was studied with 125I-fibrinogen and 125I-vWF binding to washed platelets stimulated with adenosine diphosphate plus epinephrine (10 mumol/L each). Adenosine Diphosphate 156-177 integrin subunit alpha 2b Homo sapiens 46-52 8276423-6 1993 The mixing of ADP+CK with PCr again gives a release of 1.2 H+ per monomer of CK with kapp of around 67.2 sec-1 before the reaction proceeds to steady phase where there is absorption of one H+ per ADP transphosphorylated. Adenosine Diphosphate 14-17 secretory blood group 1, pseudogene Homo sapiens 105-110 8097372-4 1993 An increase in c-fos mRNA level was also induced by ADP but not by AMP or adenosine. Adenosine Diphosphate 52-55 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 15-20 8454867-5 1993 In parallel, SNP induced endogenous ADP-ribosylation of GAPDH measured by a decreased incorporation of [32P]ADP-ribose from [32P]NAD+ in the cytosol of the SNP-treated cells. Adenosine Diphosphate 36-39 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 56-61 8454867-9 1993 Again, GAPDH inhibition was associated with NO-stimulated endogenous ADP-ribosylation of the enzyme. Adenosine Diphosphate 69-72 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 7-12 8475481-6 1993 However, rats treated with this dose (25 mg/kg) for 4 weeks showed a significant inhibition of platelet aggregation in PRP when a submaximal ADP concentrations was administered. Adenosine Diphosphate 141-144 proline rich protein 2-like 1 Rattus norvegicus 119-122 1281150-0 1992 Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. Adenosine Diphosphate 134-137 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 40-80 1508200-7 1992 Consistent with these results, elongation factor 2 from the dph5 null mutant was found to have weak ADP-ribosyl acceptor activity, which was detectable only in the presence of high concentrations of fragment A. Adenosine Diphosphate 100-103 diphthine synthase Saccharomyces cerevisiae S288C 60-64 1634508-9 1992 This ADP-ribosylation was inhibited by rho GDI much more efficiently than by smg GDS. Adenosine Diphosphate 5-8 Rap1 GTPase-GDP dissociation stimulator 1 Homo sapiens 77-84 1533057-6 1992 Binding of ADP favored Rep dimers in which both protomers bound single-stranded DNA, whereas binding of AMPP(NH)P favored simultaneous binding of both single-stranded and duplex DNA to the Rep dimer. Adenosine Diphosphate 11-14 replication protein Escherichia coli 23-26 1737752-8 1992 Ultraviolet irradiation of platelets in the presence of either [35S]GTP alpha S or [35S]UTP alpha S resulted in their specific incorporation into the alpha chain of GPIIb as previously shown with [35S]ATP alpha S. These results show that the structure of the nucleotide base has little influence on its ability to occupy the ADP-binding site on platelets, to function as an inhibitor of ADP-induced activation or to be photoincorporated into GPIIb alpha. Adenosine Diphosphate 325-328 integrin subunit alpha 2b Homo sapiens 165-170 1737752-8 1992 Ultraviolet irradiation of platelets in the presence of either [35S]GTP alpha S or [35S]UTP alpha S resulted in their specific incorporation into the alpha chain of GPIIb as previously shown with [35S]ATP alpha S. These results show that the structure of the nucleotide base has little influence on its ability to occupy the ADP-binding site on platelets, to function as an inhibitor of ADP-induced activation or to be photoincorporated into GPIIb alpha. Adenosine Diphosphate 387-390 integrin subunit alpha 2b Homo sapiens 165-170 1740142-4 1992 The stoichiometry of ADP-ribose incorporation into these actins was 1.2 mol, 1.0 mol and 2.0 mol ADP-ribose/mol of beta/gamma-actin, alpha-actin and gamma-actin, respectively. Adenosine Diphosphate 21-24 actin, alpha 2, smooth muscle, aorta Gallus gallus 133-144 1467434-6 1992 The increase of PBIgG produced by ADP was significantly greater when ITP plasma positive for anti-GPIIb/IIIa antibody was used compared with that obtained using antibody-negative ITP plasma. Adenosine Diphosphate 34-37 integrin subunit alpha 2b Homo sapiens 98-103 1820958-7 1991 An increase in PRP correlated with the elevation of the cytosolic ADP concentration, however, correlation was not uniform for different experimental groups. Adenosine Diphosphate 66-69 proline rich protein 2-like 1 Rattus norvegicus 15-18 1939086-3 1991 Balb/c 3T3 cells transfected with a plasmid containing cDNA encoding alpha i-1 expressed the alpha i-1 protein as judged both by the appearance of immunoreactive alpha i-1 protein on Western blots and by two-dimensional analysis of the proteins [32P]ADP-ribosylated by pertussis toxin. Adenosine Diphosphate 250-253 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 75-78 1939086-3 1991 Balb/c 3T3 cells transfected with a plasmid containing cDNA encoding alpha i-1 expressed the alpha i-1 protein as judged both by the appearance of immunoreactive alpha i-1 protein on Western blots and by two-dimensional analysis of the proteins [32P]ADP-ribosylated by pertussis toxin. Adenosine Diphosphate 250-253 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 99-102 1939086-3 1991 Balb/c 3T3 cells transfected with a plasmid containing cDNA encoding alpha i-1 expressed the alpha i-1 protein as judged both by the appearance of immunoreactive alpha i-1 protein on Western blots and by two-dimensional analysis of the proteins [32P]ADP-ribosylated by pertussis toxin. Adenosine Diphosphate 250-253 protein phosphatase 1, regulatory inhibitor subunit 1A Mus musculus 99-102 1658335-4 1991 In the absence of DNA, Rep protein is monomeric (Mr 72,800) up to concentrations of at least 8 microM (monomer), even in the presence of its nucleotide cofactors (ATP, ADP, ATP-gamma-S). Adenosine Diphosphate 168-171 replication protein Escherichia coli 23-26 1995321-4 1991 Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 71-76 1995321-4 1991 Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 251-256 1670772-6 1991 ATP hydrolysis to ADP and Pi is essential for A1-dependent pol delta activity, and we have shown that A1 contains an intrinsic ATPase which is stimulated by DNA. Adenosine Diphosphate 18-21 replication factor C subunit 1 Homo sapiens 46-48 1670772-6 1991 ATP hydrolysis to ADP and Pi is essential for A1-dependent pol delta activity, and we have shown that A1 contains an intrinsic ATPase which is stimulated by DNA. Adenosine Diphosphate 18-21 replication factor C subunit 1 Homo sapiens 102-104 1800620-6 1991 Addition of copper sulphate to PRP produced inhibition of platelet aggregation in response to PRP produced inhibition of platelet aggregation in response to ADP and to collagen. Adenosine Diphosphate 157-160 proline rich protein 2-like 1 Rattus norvegicus 31-34 1800620-6 1991 Addition of copper sulphate to PRP produced inhibition of platelet aggregation in response to PRP produced inhibition of platelet aggregation in response to ADP and to collagen. Adenosine Diphosphate 157-160 proline rich protein 2-like 1 Rattus norvegicus 94-97 1800620-10 1991 Further the in vitro addition of gold chloride to rat PRP resulted in marked inhibition of platelet aggregation in response to both ADP and collagen. Adenosine Diphosphate 132-135 proline rich protein 2-like 1 Rattus norvegicus 54-57 1800625-7 1991 Addition of rising concentrations of zinc sulphate to rat PRP produced inhibition of ADP-induced platelet aggregation. Adenosine Diphosphate 85-88 proline rich protein 2-like 1 Rattus norvegicus 58-61 1800625-15 1991 Magnesium sulphate in the range of doses tested significantly enhanced platelet aggregation of PRP in response to both ADP and collagen, and the responses observed were not dose dependent. Adenosine Diphosphate 119-122 proline rich protein 2-like 1 Rattus norvegicus 95-98 2175608-3 1990 Ticlopidine inhibits ADP-induced binding of fibrinogen to platelet glycoprotein GP IIb-IIIa but not shape change and increases deaggregation. Adenosine Diphosphate 21-24 integrin subunit alpha 2b Homo sapiens 80-86 1701661-3 1990 On average, 1.1 mol of ADP-ribosyl residue was incorporated into 1 mol of MBP. Adenosine Diphosphate 23-26 myelin basic protein Rattus norvegicus 74-77 2100307-0 1990 Guinea-pig megakaryocytes can respond to external ADP by activating Ca2(+)-dependent potassium conductance. Adenosine Diphosphate 50-53 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 68-71 2100307-17 1990 It was concluded that megakaryocytes of the guinea-pig can respond to external ADP by increasing [Ca2+]i and consequently by activating Ca2(+)-dependent K+ channels in the membrane. Adenosine Diphosphate 79-82 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 98-101 2100307-17 1990 It was concluded that megakaryocytes of the guinea-pig can respond to external ADP by increasing [Ca2+]i and consequently by activating Ca2(+)-dependent K+ channels in the membrane. Adenosine Diphosphate 79-82 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 136-139 2148682-9 1990 The reaction in the presence of poly(deoxythymidylic acid) or duplex DNA ceases when about 60% of the available ATP is hydrolyzed, reflecting an ADP-mediated dissociation of recA protein from the DNA that is governed by the ADP/ATP ratio. Adenosine Diphosphate 224-227 RAD51 recombinase Homo sapiens 174-178 1973186-4 1990 Further, we have causally related these events to the qualitative upregulation of CD11b/CD18, as exemplified by its inducible binding of factor X. Micromolar concentrations of ADP or ATP produce dose-dependent increase in monocyte cytosolic free [Ca2+]i through mobilization from intracellular stores coupled with a sustained, EGTA-sensitive, influx of Ca2+ from the external compartment. Adenosine Diphosphate 176-179 integrin subunit alpha M Homo sapiens 82-87 1973186-8 1990 In monocytes, depolarizing conditions by high external [K+] or by the Na+ ionophore gramicidin D mimicked the stimulatory effect of ADP, inducing increased cytosolic free [Ca2+]i and 125I-factor X binding to CD11b/CD18. Adenosine Diphosphate 132-135 integrin subunit alpha M Homo sapiens 208-213 2385828-5 1990 CS-1 also inhibited aggregation of ADP- and thrombin-stimulated platelets by 2- and 4-fold, respectively. Adenosine Diphosphate 35-38 chorionic somatomammotropin hormone 1 Homo sapiens 0-4 2303480-3 1990 Prior exposure of saponin-treated platelets to anti-p24/CD9 inhibited the [32P] ADP-ribosylation of the alpha 41 protein by pertussis toxin. Adenosine Diphosphate 80-83 CD9 molecule Homo sapiens 56-59 2306515-8 1990 Thus, we conclude that binding of monoclonal immunoglobulin G molecules to the CD9 antigen raises [Ca2+]i through the effect of secreted ADP and thromboxane on platelets, and that CD9 antigen is not directly involved in induction of Ca2+ influx and mobilization. Adenosine Diphosphate 137-140 CD9 molecule Homo sapiens 79-82 1965600-7 1990 Values of [ATP] + [ADP] and intracellular inorganic phosphoric acid [Pi] were almost independent of pHi, whereas the [ATP]/[ADP] ratio decreased with increase in pHi. Adenosine Diphosphate 124-127 glucose-6-phosphate isomerase Oryctolagus cuniculus 162-165 2287610-8 1990 By our method, the DEAE-Sephadex step is omitted, the G6PD is eluted from P11 with citrate and NADP, and from 2"5" ADP-Sepharose with KC1, NADP and EDTA. Adenosine Diphosphate 96-99 glucose-6-phosphate dehydrogenase Homo sapiens 54-58 33590615-8 2021 In platelets, the opening of the channel Kca 1.1 led to a reduced sensitivity to agonists with blunted aggregation in response to ADP, with an inhibitory capacity additive to that of aspirin. Adenosine Diphosphate 130-133 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 41-48 33590615-10 2021 The opening of the Kca 1.1 resulted in cell hyperpolarization impairing free intracellular calcium in ADP-stimulated platelets and megakaryocytes. Adenosine Diphosphate 102-105 potassium calcium-activated channel subfamily M alpha 1 Homo sapiens 19-26 34840926-6 2021 Similarly, nucleotides such as Adenosine tri-phosphate (ATP), Adenosine di-phosphate (ADP), Uridine tri-phosphate (UTP), Uridine di-phosphate (UDP) and Uridine diphosphoglucose (UDPG) induced elevated reactive oxygen species (ROS) and tartrate Resistant Acid Phosphatase (TRAP) activity in RAW264.7 cells. Adenosine Diphosphate 86-89 acid phosphatase 5, tartrate resistant Mus musculus 235-270 34840926-6 2021 Similarly, nucleotides such as Adenosine tri-phosphate (ATP), Adenosine di-phosphate (ADP), Uridine tri-phosphate (UTP), Uridine di-phosphate (UDP) and Uridine diphosphoglucose (UDPG) induced elevated reactive oxygen species (ROS) and tartrate Resistant Acid Phosphatase (TRAP) activity in RAW264.7 cells. Adenosine Diphosphate 86-89 acid phosphatase 5, tartrate resistant Mus musculus 272-276 34840926-7 2021 The ADP-induced TRAP could be inhibited by clopidogrel a P2Y12 inhibitor. Adenosine Diphosphate 4-7 acid phosphatase 5, tartrate resistant Mus musculus 16-20 34812732-4 2021 The structures reveal a high flexibility of myosin in each state and provide valuable insights into the structural transitions of myosin-V upon ADP release and binding of AppNHp, as well as the actomyosin interface. Adenosine Diphosphate 144-147 myosin VA Homo sapiens 130-138 34582060-1 2021 AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. Adenosine Diphosphate 128-131 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 0-28 34582060-1 2021 AMP-activated protein kinase (AMPK) is recognized as a critical regulator of cellular energy metabolism impacted by AMP/ATP and ADP/ATP ratios, or glucose- and fatty acid-derived metabolites. Adenosine Diphosphate 128-131 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 30-34 34400216-3 2021 One of the most highly upregulated genes in atrophic muscle is AMP deaminase 3 (AMPD3: AMP IMP+NH3), which controls the content of intracellular adenine nucleotides (AdN; ATP + ADP + AMP). Adenosine Diphosphate 179-182 adenosine monophosphate deaminase 3 Mus musculus 63-78 34400216-3 2021 One of the most highly upregulated genes in atrophic muscle is AMP deaminase 3 (AMPD3: AMP IMP+NH3), which controls the content of intracellular adenine nucleotides (AdN; ATP + ADP + AMP). Adenosine Diphosphate 179-182 adenosine monophosphate deaminase 3 Mus musculus 80-85 34545070-3 2021 However, RAD51 can bind ssDNA in non-productive ADP-bound or nucleotide-free states, and ATP-RAD51-ssDNA complexes hydrolyse ATP over time. Adenosine Diphosphate 48-51 RAD51 recombinase Homo sapiens 9-14 34545070-5 2021 We find RAD51 paralogs promote the turnover of ADP-bound RAD-51 from ssDNA, in striking contrast to their ability to stabilize productive ATP-bound RAD-51 nucleoprotein filaments. Adenosine Diphosphate 47-50 RAD51 recombinase Homo sapiens 8-13 34545070-5 2021 We find RAD51 paralogs promote the turnover of ADP-bound RAD-51 from ssDNA, in striking contrast to their ability to stabilize productive ATP-bound RAD-51 nucleoprotein filaments. Adenosine Diphosphate 47-50 RAD51 recombinase Homo sapiens 57-63 34521893-0 2021 Novel cryo-EM structure of an ADP-bound GroEL-GroES complex. Adenosine Diphosphate 30-33 heat shock protein family D (Hsp60) member 1 Homo sapiens 40-45 34465804-7 2021 Via the same association with platelets, THP-1 monocyte adhesion to the endothelial intercellular adhesion molecule 1 (ICAM-1) is induced by ADP. Adenosine Diphosphate 141-144 intercellular adhesion molecule 1 Homo sapiens 84-117 34465804-7 2021 Via the same association with platelets, THP-1 monocyte adhesion to the endothelial intercellular adhesion molecule 1 (ICAM-1) is induced by ADP. Adenosine Diphosphate 141-144 intercellular adhesion molecule 1 Homo sapiens 119-125 34575427-8 2021 Docking investigation revealed that the drug binds to the ADP/ATP sites on KIR6.1/2 and SUR2A/B and on the sulfonylureas site showing low binding energy <6 Kcal/mol for the KIR6.1/2-SUR2 subunits vs. the <4 Kcal/mol for the KIR6.2-SUR1. Adenosine Diphosphate 58-61 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 224-230 35620482-3 2022 Here, a multi-microsecond length molecular dynamics (MD) simulation of STK17B in the three different states (ligand-free, ADP-bound, and ligand-bound states) was carried out to uncover the conformational plasticity of the P-loop. Adenosine Diphosphate 122-125 serine/threonine kinase 17b Homo sapiens 71-77 35090055-3 2022 Here, we report the crystal and cryo-electron microscopy structures of NLRP9 in an ADP-bound state, revealing inactive and closed conformations of NLRP9 and its similarities to other structurally characterised NLRs. Adenosine Diphosphate 83-86 NLR family pyrin domain containing 9 Homo sapiens 71-76 35090055-3 2022 Here, we report the crystal and cryo-electron microscopy structures of NLRP9 in an ADP-bound state, revealing inactive and closed conformations of NLRP9 and its similarities to other structurally characterised NLRs. Adenosine Diphosphate 83-86 NLR family pyrin domain containing 9 Homo sapiens 147-152 35211819-7 2022 A higher ADP- and TRAP-dependent platelet reactivity was observed in overweight and obese patients (ADP: median 27 units (U) (IQR 13-39.5) vs. 7 U (6-15), p < 0.001 and TRAP: 97 U (73-118.5) vs. 85 U (36-103), p = 0.035). Adenosine Diphosphate 9-12 TRAP Homo sapiens 169-173 35211819-7 2022 A higher ADP- and TRAP-dependent platelet reactivity was observed in overweight and obese patients (ADP: median 27 units (U) (IQR 13-39.5) vs. 7 U (6-15), p < 0.001 and TRAP: 97 U (73-118.5) vs. 85 U (36-103), p = 0.035). Adenosine Diphosphate 100-103 TRAP Homo sapiens 18-22 35211819-7 2022 A higher ADP- and TRAP-dependent platelet reactivity was observed in overweight and obese patients (ADP: median 27 units (U) (IQR 13-39.5) vs. 7 U (6-15), p < 0.001 and TRAP: 97 U (73-118.5) vs. 85 U (36-103), p = 0.035). Adenosine Diphosphate 100-103 TRAP Homo sapiens 169-173 35593054-1 2022 Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y1,12,13 receptors. Adenosine Diphosphate 92-95 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 0-48 35593054-1 2022 Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y1,12,13 receptors. Adenosine Diphosphate 92-95 ectonucleoside triphosphate diphosphohydrolase 2 Rattus norvegicus 50-58 2558559-4 1989 simultaneous addition of ADP and TDS to PRP produced a synergistic effect. Adenosine Diphosphate 25-28 proline rich protein 2-like 1 Rattus norvegicus 40-43 2529923-8 1989 Using monoclonal antibodies (MoAbs) against the platelet glycoproteins (GP) IIb/IIIa and Ib (MoAbs 10E5 and 6D1, respectively), we demonstrated that the ADP-induced increase in platelet-vWF expression on control platelets primarily involved the binding of secreted platelet-vWF to the platelet GPIIb/IIIa. Adenosine Diphosphate 153-156 integrin subunit alpha 2b Homo sapiens 294-299 2620270-3 1989 As to the effect of the four McAbs on platelet aggregation, the results showed: 1) HIP4 and HIP8 can completely inhibit platelet aggregation induced by ADP or collagen, but not that induced by thrombin or ristocetin. Adenosine Diphosphate 152-155 MAGE family member A3 Homo sapiens 92-96 2749584-1 1989 Forskolin, a plant (Coleus forskohlii) diterpene, inhibits ADP-induced (human: IC50, 2.3 +/- 1.0 microM; rat: IC50, 1.2 +/- 0.5 microM) and collagen-induced (human: IC50, 2.4 +/- 1.2 microM; rat: 0.6 +/- 0.2 microM) platelet aggregation in human and rat platelet-rich plasma (PRP). Adenosine Diphosphate 59-62 proline rich protein 2-like 1 Rattus norvegicus 276-279 2521440-3 1989 In addition, the enzyme binds 1 mol ADP/mol F1 and 3 mol AMP.PNP, the latter of which can bind in complex formation with divalent cation and displace the Mg2+ at the exchangeable site. Adenosine Diphosphate 36-39 coagulation factor III, tissue factor Rattus norvegicus 44-52 3138409-9 1988 These data indicate that these sulfonylureas inhibit the metabolic flux through the pyruvate carboxylase reaction by decreasing mitochondrial ATP/ADP and acetyl-coenzyme A/CoASH ratios. Adenosine Diphosphate 146-149 pyruvate carboxylase Rattus norvegicus 84-104 2835359-0 1988 The saturable high affinity association of factor X to ADP-stimulated monocytes defines a novel function of the Mac-1 receptor. Adenosine Diphosphate 55-58 integrin subunit alpha M Homo sapiens 112-117 3129724-4 1988 However, the 355-residue Gz alpha lacks a consensus site for ADP-ribosylation by pertussis toxin, and its amino acid sequence varies within a number of regions that are strongly conserved among all of the other G-protein alpha subunits. Adenosine Diphosphate 61-64 G protein subunit alpha z Homo sapiens 25-33 2829739-1 1988 The purpose of this study was to determine whether changes in ADP-ribosylation affect expression of the gene encoding the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in H4IIE hepatoma cells. Adenosine Diphosphate 62-65 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 143-176 2829739-1 1988 The purpose of this study was to determine whether changes in ADP-ribosylation affect expression of the gene encoding the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) in H4IIE hepatoma cells. Adenosine Diphosphate 62-65 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 178-183 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 120-123 suppressor of cytokine signaling 7 Homo sapiens 115-119 2889735-11 1987 When F1 was first photolabeled with a low concentration of NAP4-ADP, leading to the covalent binding of 1.5 mol of NAP4-ADP/mol F1, with the bound NAP4-ADP distributed equally between the alpha and beta subunits, a subsequent photoirradiation in the presence of 2-N3[alpha-32P]ADP resulted in covalent binding of the 2-N3[alpha-32P]ADP to both alpha and beta subunits. Adenosine Diphosphate 120-123 suppressor of cytokine signaling 7 Homo sapiens 115-119 2959279-13 1987 The effects of an ATP-regenerating system on the measured Ca2+ uptake is explained in terms of both removal of ADP and precipitation of Ca3(PO4)2 within the vesicles. Adenosine Diphosphate 111-114 carbonic anhydrase 2 Homo sapiens 58-61 3607284-6 1987 When the pool of GP IIb/IIIa molecules exposed on the surface of unstimulated platelets was reacted with the monoclonal antibody LJ-CP3 to block ADP-induced fibrinogen binding and platelet aggregation, stimulation with thrombin or PMA still induced substantial binding of antibody and fibrinogen, and aggregation ensued. Adenosine Diphosphate 145-148 integrin subunit alpha 2b Homo sapiens 17-23 2875734-2 1986 The cross-linked ATPase resembles the native enzyme in the following properties: specific activity; activation by lauryldimethylamine N-oxide (LDAO); binding of aurovertin D and ADP; cross-linking products with 3,3"-dithiobis(succinimidyl propionate); binding to ATPase-stripped everted membrane vesicles and the N,N"-dicyclohexylcarbodiimide sensitivity of the rebound enzyme. Adenosine Diphosphate 178-181 ATPase Escherichia coli 17-23 3775692-3 1986 Responses to collagen, thrombin, and the Paf-acether derivatives were invariably accompanied by substantial, dose-related increases in plasma levels of thromboxane B2 in samples obtained 30 s after agonist administration, whereas following ADP, no change in plasma thromboxane B2 was detected at any dose level. Adenosine Diphosphate 240-243 prothrombin Oryctolagus cuniculus 23-31 3026316-6 1986 In contrast, stimulation with thrombin caused a significant increase in the labelling of IP3 at 10 s. These differences in the changes in polyphosphoinositide metabolism in ADP- and thrombin-stimulated platelets are consistent with the hypothesis that the decrease in PIP2 in ADP-stimulated platelets may be due not to degradation of PIP2 by phospholipase C, but rather to a shift in the equilibrium between PIP2 and phosphatidylinositol 4-phosphate (PIP). Adenosine Diphosphate 173-176 prothrombin Oryctolagus cuniculus 30-38 3026316-6 1986 In contrast, stimulation with thrombin caused a significant increase in the labelling of IP3 at 10 s. These differences in the changes in polyphosphoinositide metabolism in ADP- and thrombin-stimulated platelets are consistent with the hypothesis that the decrease in PIP2 in ADP-stimulated platelets may be due not to degradation of PIP2 by phospholipase C, but rather to a shift in the equilibrium between PIP2 and phosphatidylinositol 4-phosphate (PIP). Adenosine Diphosphate 276-279 prothrombin Oryctolagus cuniculus 30-38 3026316-6 1986 In contrast, stimulation with thrombin caused a significant increase in the labelling of IP3 at 10 s. These differences in the changes in polyphosphoinositide metabolism in ADP- and thrombin-stimulated platelets are consistent with the hypothesis that the decrease in PIP2 in ADP-stimulated platelets may be due not to degradation of PIP2 by phospholipase C, but rather to a shift in the equilibrium between PIP2 and phosphatidylinositol 4-phosphate (PIP). Adenosine Diphosphate 276-279 prothrombin Oryctolagus cuniculus 182-190 3087006-3 1986 Collagen and arachidonic acid (AA) induced aggregation in heparin-PRP only, and ADP induced greater aggregation in heparin-PRP than in citrate-PRP. Adenosine Diphosphate 80-83 proline rich protein 2-like 1 Rattus norvegicus 123-126 3964286-5 1986 Both the rate and extent of digestion by DNase I and MNase were enhanced after ADP-ribosylation which was the maximum for 3-day rats. Adenosine Diphosphate 79-82 deoxyribonuclease 1 Rattus norvegicus 41-48 2944344-5 1986 Of the four anti-GPIIb-IIIa antibodies, three completely inhibited platelet aggregation induced with ADP or collagen, while the other caused only partial inhibition. Adenosine Diphosphate 101-104 integrin subunit alpha 2b Homo sapiens 17-22 3911480-2 1985 Following oral administration of molsidomine at doses of 6 or 15 mg/kg to rabbits, their blood platelets in PRP ex vivo required higher threshold concentrations of ADP, AA and thrombin to be aggregated. Adenosine Diphosphate 164-167 major prion protein Oryctolagus cuniculus 108-111 4062938-1 1985 Inactivation of 3-hydroxy-3-methylglutaryl Coenzyme A reductase by reductase kinase and ATP-Mg needs either ADP or 5"-AMP as cofactors. Adenosine Diphosphate 108-111 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 16-63 3995044-3 1985 The formation of CTP was accompanied by the production of equivalent amounts of ADP from ATP and glutamate from glutamine. Adenosine Diphosphate 80-83 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1 Mus musculus 17-20 3155488-4 1985 A previously described monoclonal antibody specific for the GPIIb/IIIa complex (AP-2) inhibited platelet aggregation induced by ADP, thrombin, collagen, or arachidonic acid (Pidard et al, J Biol Chem 258:12582-12586, 1983). Adenosine Diphosphate 128-131 integrin subunit alpha 2b Homo sapiens 60-65 3155488-4 1985 A previously described monoclonal antibody specific for the GPIIb/IIIa complex (AP-2) inhibited platelet aggregation induced by ADP, thrombin, collagen, or arachidonic acid (Pidard et al, J Biol Chem 258:12582-12586, 1983). Adenosine Diphosphate 128-131 transcription factor AP-2 alpha Homo sapiens 80-84 6393142-1 1984 FCE (+)22509, a chemically stable carboprostacyclin analogue, inhibited in vitro ADP-induced platelet aggregation in rat platelet-rich plasma (PRP) (IC50 = 7.7 ng/ml). Adenosine Diphosphate 81-84 proline rich protein 2-like 1 Rattus norvegicus 143-146 6393142-2 1984 Subcutaneous administration of the drug, inhibited both ADP-induced platelet aggregation in rat PRP (ED50 = 0.26 mg/kg) and mortality of mice induced by collagen plus adrenaline (ED50 = 0.35 mg/kg). Adenosine Diphosphate 56-59 proline rich protein 2-like 1 Rattus norvegicus 96-99 6317378-4 1983 ADP inhibits binding of the complex to the submitochondrial particles and protects both cytochrome c oxidase activity and membrane lipid. Adenosine Diphosphate 0-3 cytochrome c Sus scrofa 88-100 6314326-2 1983 We have purified dnaK protein to homogeneity and have demonstrated that it possesses a weak DNA-independent ATPase activity, which results in the production of ADP and Pi. Adenosine Diphosphate 160-163 ATPase Escherichia coli 108-114 6419380-4 1983 PRP collected 7 days after MCTP treatment had a 15% decrease in both slope and maximum aggregation to 1 X 10(-5) M ADP and a 25% decrease in response to 2 X 10(-6) M ADP relative to the control group. Adenosine Diphosphate 115-118 proline rich protein 2-like 1 Rattus norvegicus 0-3 6419380-4 1983 PRP collected 7 days after MCTP treatment had a 15% decrease in both slope and maximum aggregation to 1 X 10(-5) M ADP and a 25% decrease in response to 2 X 10(-6) M ADP relative to the control group. Adenosine Diphosphate 166-169 proline rich protein 2-like 1 Rattus norvegicus 0-3 6617661-8 1983 These experiments indicate that reduction of factor Xa leads to a reversible alteration of the molecule which inhibits platelet aggregation induced by ADP. Adenosine Diphosphate 151-154 coagulation factor X Homo sapiens 45-54 6318282-1 1983 Incubation of four purified rat liver HMG-CoA reductase phosphatases, with ATP, ADP and AMP caused a concentration-dependent inactivation of enzyme activities. Adenosine Diphosphate 80-83 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 38-55 6628537-2 1983 Thrombin-induced exhaustion of the pool of releasable ADP, or inactivation of cyclooxygenase with aspirin or with arachidonic acid failed to suppress Cx-induced activation. Adenosine Diphosphate 54-57 prothrombin Oryctolagus cuniculus 0-8 6604123-6 1983 Further C3a and C3a des-arg exhibited synergism with ADP of equal significance in both aggregation and the release reaction. Adenosine Diphosphate 53-56 complement C3 Homo sapiens 16-19 6604123-7 1983 The concentrations of C3a required for the platelet-stimulating activity involve relatively small number of molecules per platelet (4,000-10,000 for the synergistic reaction with ADP). Adenosine Diphosphate 179-182 complement C3 Homo sapiens 22-25 6222041-4 1983 Upon addition of ADP, the recA protein-duplex DNA complex dissociates. Adenosine Diphosphate 17-20 RAD51 recombinase Homo sapiens 26-30 6860633-0 1983 Relationship between histone H1 poly(adenosine diphosphate ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate ribose) antibody. Adenosine Diphosphate 37-58 H1.0 linker histone Homo sapiens 21-31 6860633-0 1983 Relationship between histone H1 poly(adenosine diphosphate ribosylation) and histone H1 phosphorylation using anti-poly(adenosine diphosphate ribose) antibody. Adenosine Diphosphate 37-58 H1.0 linker histone Homo sapiens 77-87 6337158-6 1983 While 100-200 mol of ATP are hydrolyzed/mol of heteroduplex base pair formed under standard reaction conditions in the presence of SSB, this value is reduced to 16 at levels of ADP lower than that required to dissociate the complexes. Adenosine Diphosphate 177-180 single-stranded DNA-binding protein Escherichia coli 131-134 7142187-11 1982 These findings suggest that regulation of glycolysis in round spermatids by glyceraldehyde-3-phosphate dehydrogenase is most likely and that glyceraldehyde-3-phosphate dehydrogenase is inhibited by the adenine nucleotides, particularly by 5"-AMP and ADP as inhibitors competitive with NAD. Adenosine Diphosphate 250-253 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 141-181 7074085-1 1982 The kinetics of binding of the nonhydrolyzable nucleotides adenosine 5"-diphosphate (ADP) and adenosine 5"-(beta, gamma-imidotriphosphate) (AMP-PNP) to myosin subfragment 1 (SF-1) and actosubfragment 1 (acto-SF-1) were reinvestigated. Adenosine Diphosphate 59-83 splicing factor 1 Homo sapiens 152-178 7092825-8 1982 In experiments where the endogenous ATP in these mitochondria was shifted to higher concentrations by incubation with oxidizable substrates or defatted bovine serum albumin, the rate of ADP translocation was increased, with a linear correlation being observed between endogenous ATP concentrations and the rate of ADP translocation. Adenosine Diphosphate 186-189 albumin Rattus norvegicus 159-172 7092825-8 1982 In experiments where the endogenous ATP in these mitochondria was shifted to higher concentrations by incubation with oxidizable substrates or defatted bovine serum albumin, the rate of ADP translocation was increased, with a linear correlation being observed between endogenous ATP concentrations and the rate of ADP translocation. Adenosine Diphosphate 314-317 albumin Rattus norvegicus 159-172 6459580-1 1982 Actin-myosin subfragment-1 (SF-1) or actin-heavy meromyosin is dissociated by the binding of ADP and vanadate (Vi) under conditions such that ADP alone does not dissociate the complex. Adenosine Diphosphate 93-96 splicing factor 1 Homo sapiens 0-33 6459580-1 1982 Actin-myosin subfragment-1 (SF-1) or actin-heavy meromyosin is dissociated by the binding of ADP and vanadate (Vi) under conditions such that ADP alone does not dissociate the complex. Adenosine Diphosphate 142-145 splicing factor 1 Homo sapiens 0-33 7466847-2 1980 No changes in the brain content of ATP, ADP and AMP were found in rats after chronic exposure, whereas the content of ATP in the brain of rats acutely poisoned with CS2 was significantly higher (21%) accompanied by decrease in the content of ADP (10%) and AMP (45%). Adenosine Diphosphate 40-43 calsyntenin 2 Rattus norvegicus 165-168 7466847-2 1980 No changes in the brain content of ATP, ADP and AMP were found in rats after chronic exposure, whereas the content of ATP in the brain of rats acutely poisoned with CS2 was significantly higher (21%) accompanied by decrease in the content of ADP (10%) and AMP (45%). Adenosine Diphosphate 242-245 calsyntenin 2 Rattus norvegicus 165-168 523684-17 1979 Inhibition of ADP-induced rat blood platelet aggregation after "intra-arterial" administration was shown only by the derivatives with a single change in the natural configuration either at C-8 or at C-15. Adenosine Diphosphate 14-17 nuclear distribution C, dynein complex regulator Rattus norvegicus 199-203 213433-2 1978 In addition to inhibition by ADP and stimulation by GMP, fucokinase responds selectively to a series of nucleotide sugars. Adenosine Diphosphate 29-32 fucose kinase Homo sapiens 57-67 13840-15 1977 Pea-seed glucokinase was inhibited by relatively low concentrations of ADP. Adenosine Diphosphate 71-74 glucokinase Homo sapiens 9-20 1002684-6 1976 In the presence of Mg2+, the binding constants of the first two ADP"s are both 7.6 X 10(-2) muM-1, that of the third ADP being 4.0 muM-1. Adenosine Diphosphate 64-67 PWWP domain containing 3A, DNA repair factor Homo sapiens 92-97 1002684-6 1976 In the presence of Mg2+, the binding constants of the first two ADP"s are both 7.6 X 10(-2) muM-1, that of the third ADP being 4.0 muM-1. Adenosine Diphosphate 64-67 PWWP domain containing 3A, DNA repair factor Homo sapiens 131-136 1002684-6 1976 In the presence of Mg2+, the binding constants of the first two ADP"s are both 7.6 X 10(-2) muM-1, that of the third ADP being 4.0 muM-1. Adenosine Diphosphate 117-120 PWWP domain containing 3A, DNA repair factor Homo sapiens 92-97 1002684-6 1976 In the presence of Mg2+, the binding constants of the first two ADP"s are both 7.6 X 10(-2) muM-1, that of the third ADP being 4.0 muM-1. Adenosine Diphosphate 117-120 PWWP domain containing 3A, DNA repair factor Homo sapiens 131-136 1002684-7 1976 In the absence of Mg2+, the binding constant of the first ADP is 7.6 X 10(-2) muM-1, the constants of the other two ADP"s both being 4.0 X 10(-2) muM-1. Adenosine Diphosphate 58-61 PWWP domain containing 3A, DNA repair factor Homo sapiens 78-83 1002684-7 1976 In the absence of Mg2+, the binding constant of the first ADP is 7.6 X 10(-2) muM-1, the constants of the other two ADP"s both being 4.0 X 10(-2) muM-1. Adenosine Diphosphate 58-61 PWWP domain containing 3A, DNA repair factor Homo sapiens 146-151 1002684-7 1976 In the absence of Mg2+, the binding constant of the first ADP is 7.6 X 10(-2) muM-1, the constants of the other two ADP"s both being 4.0 X 10(-2) muM-1. Adenosine Diphosphate 116-119 PWWP domain containing 3A, DNA repair factor Homo sapiens 146-151 974086-2 1976 Measurements of the nuclear Overhauser effect (NOE), which is a nuclear magnetic resonance (NMR) double resonance technique, for the H-2 proton on ADP have been used to identify the amino acid residue binding ADP at the active site of creatine kinase. Adenosine Diphosphate 147-150 relaxin 2 Homo sapiens 133-136 974086-2 1976 Measurements of the nuclear Overhauser effect (NOE), which is a nuclear magnetic resonance (NMR) double resonance technique, for the H-2 proton on ADP have been used to identify the amino acid residue binding ADP at the active site of creatine kinase. Adenosine Diphosphate 209-212 relaxin 2 Homo sapiens 133-136 1278350-1 1976 The influence of four agents--pyrazolidinedione derivatives on the ADP-induced aggregation and activity of glycolytic enzymes--glyceraldehydrophosphate dehydrogenase and lactate dehydrogenase (GAPD, LDG) and of the anatomic oxidation enzyme--glucose-6-phosphate dehydrogenase (G-6-PD) was studied. Adenosine Diphosphate 67-70 glucose-6-phosphate dehydrogenase Homo sapiens 234-275 1278350-1 1976 The influence of four agents--pyrazolidinedione derivatives on the ADP-induced aggregation and activity of glycolytic enzymes--glyceraldehydrophosphate dehydrogenase and lactate dehydrogenase (GAPD, LDG) and of the anatomic oxidation enzyme--glucose-6-phosphate dehydrogenase (G-6-PD) was studied. Adenosine Diphosphate 67-70 glucose-6-phosphate dehydrogenase Homo sapiens 277-283 12937-2 1976 NAD-IDH activity required ADP for activation. Adenosine Diphosphate 26-29 isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Rattus norvegicus 4-7 127930-13 1975 Adenosine diphosphate and inorganic phosphate (Pi) act as competitive inhibitors of Escherichia coli ATPase. Adenosine Diphosphate 0-21 ATPase Escherichia coli 101-107 127930-14 1975 The Ki values for Pi were 1.6 +/- 0.1 mM for the membrane-bound ATPase and 1.3 +/- 0.1 mM for the enzyme in soluble form, the Ki values for ADP being 1.7 mM and 0.75 mM for the membrane-bound and soluble ATPase, respectively. Adenosine Diphosphate 140-143 ATPase Escherichia coli 64-70 127930-14 1975 The Ki values for Pi were 1.6 +/- 0.1 mM for the membrane-bound ATPase and 1.3 +/- 0.1 mM for the enzyme in soluble form, the Ki values for ADP being 1.7 mM and 0.75 mM for the membrane-bound and soluble ATPase, respectively. Adenosine Diphosphate 140-143 ATPase Escherichia coli 204-210 1176452-14 1975 Consistent with these result was the observation that with liver mitochondrial the magnitude of the cytochrome b oxidation-reduction shift was greater for Ca2+ than for ADP, whereas calcium responses never surpassed the ADP response in heart mitochondria. Adenosine Diphosphate 169-172 cytochrome b, mitochondrial Rattus norvegicus 100-112 804475-2 1975 Microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase prepared from either rat liver or human fibroblasts was shown to be inactivated in vitro by a factor in extracts of cultured human fibroblasts in a reaction requiring ATP or ADP and Mg2+ or Mn2+. Adenosine Diphosphate 233-236 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 11-58 168907-12 1975 The influence on adenosine diphosphate (ADP)-induced thrombocyte aggregation has been dtudied in vitro with platelet rich rat plasma (PRP) using a turbidimetric method. Adenosine Diphosphate 17-38 proline rich protein 2-like 1 Rattus norvegicus 134-137 168907-12 1975 The influence on adenosine diphosphate (ADP)-induced thrombocyte aggregation has been dtudied in vitro with platelet rich rat plasma (PRP) using a turbidimetric method. Adenosine Diphosphate 40-43 proline rich protein 2-like 1 Rattus norvegicus 134-137 4151516-1 1974 5-Oxoprolinase catalyzes the conversion of 5-oxo-L-proline (L-pyroglutamate, L-2-pyrrolidone-5-carboxylate) to L-glutamate with concomitant stoichiometric cleavage of ATP to ADP and inorganic orthophosphate. Adenosine Diphosphate 174-177 5-oxoprolinase (ATP-hydrolysing) Mus musculus 0-14 34041517-3 2021 Using a series of platelet function assays, we found that G-Rb2 and G-Rd2, among the ten PNF saponin monomers, significantly inhibited human platelet aggregation and activation induced by adenosine diphosphate (ADP) in vitro. Adenosine Diphosphate 211-214 RB transcriptional corepressor like 2 Homo sapiens 60-63 34041517-3 2021 Using a series of platelet function assays, we found that G-Rb2 and G-Rd2, among the ten PNF saponin monomers, significantly inhibited human platelet aggregation and activation induced by adenosine diphosphate (ADP) in vitro. Adenosine Diphosphate 211-214 peripherin 2 Homo sapiens 70-73 34041517-4 2021 The 50% inhibitory concentration (IC50) of G-Rb2 and G-Rd2 against ADP-induced platelet aggregation was 85.5 +- 4.5 mug mL-1 and 51.4 +- 4.6 mug mL-1, respectively. Adenosine Diphosphate 67-70 RB transcriptional corepressor like 2 Homo sapiens 45-48 34041517-4 2021 The 50% inhibitory concentration (IC50) of G-Rb2 and G-Rd2 against ADP-induced platelet aggregation was 85.5 +- 4.5 mug mL-1 and 51.4 +- 4.6 mug mL-1, respectively. Adenosine Diphosphate 67-70 peripherin 2 Homo sapiens 55-58 33872376-5 2021 Concomitantly, LIG1 deficiency induces ADP-ribosylation of histone H3 in a PARP1-HPF1-dependent manner. Adenosine Diphosphate 39-42 poly(ADP-ribose) polymerase 1 L homeolog Xenopus laevis 75-80 33730678-5 2021 Mechanistic studies showed that compound 38 bound to RIPK3 with high affinity (Kd = 7.1 nM), and inhibited RIPK3 kinase activity in a ADP-Glo functional assay. Adenosine Diphosphate 134-137 receptor interacting serine/threonine kinase 3 Homo sapiens 107-112 33433747-11 2021 Successful percutaneous mitral valve repair with the MitraClip system induces a stable change in mitral valve geometry mainly at the ADP, suggesting a significant annuloplasty that contributes to the reduction of mitral regurgitation. Adenosine Diphosphate 134-137 CAP-Gly domain containing linker protein 1 Homo sapiens 53-62 33908345-4 2021 These structures, together with in vivo and in vitro functional analyses, support a model in which ATP-loaded RIO1 cooperates with ribosomal protein RPS26/eS26 to displace DIM2 from the 18S rRNA 3" end, thereby triggering final cleavage by NOB1; release of ADP then leads to RIO1 dissociation from the 40S subunit. Adenosine Diphosphate 257-260 ribosomal protein S26 Homo sapiens 149-154 33513284-7 2021 OSM-3 bound to ADP or devoid of a nucleotide shows features of ADP-kinesins with a docked neck-linker. Adenosine Diphosphate 15-18 kinesin family member 17 Homo sapiens 0-5 33626394-5 2021 KEY FINDINGS: Compared with vehicle control, alcohol pretreatment significantly reduced hydrolysis of clopidogrel as a result of significant down-regulation of Nrf2-mediated Ces1 expression (responsible for the formation of clopidogrel carboxylate), increased metabolic activation of clopidogrel due to significant up-regulation of Cyp2c (for the formation of active thiol metabolite H4), and consequently enhanced inhibition of ADP-induced platelet aggregation and activation by clopidogrel. Adenosine Diphosphate 429-432 carboxylesterase 1G Mus musculus 174-178 33626394-6 2021 SIGNIFICANCE: Short-term standard alcohol consumption would significantly enhance suppression of ADP-induced platelet aggregation and activation by clopidogrel through significant inhibition of Nrf2/Ces1 signaling pathway and induction of Cyp2c, suggesting that alcohol may interact with drugs that are predominantly metabolized by CES1 or CYP2C in patient care, including clopidogrel. Adenosine Diphosphate 97-100 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 239-244 33626394-6 2021 SIGNIFICANCE: Short-term standard alcohol consumption would significantly enhance suppression of ADP-induced platelet aggregation and activation by clopidogrel through significant inhibition of Nrf2/Ces1 signaling pathway and induction of Cyp2c, suggesting that alcohol may interact with drugs that are predominantly metabolized by CES1 or CYP2C in patient care, including clopidogrel. Adenosine Diphosphate 97-100 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 340-345 33158944-3 2021 Mac1 likely counters host-mediated anti-viral ADP-ribosylation, a posttranslational modification that is part of the host response to viral infections. Adenosine Diphosphate 46-49 integrin subunit alpha M Homo sapiens 0-4 33490644-3 2021 In the present study, we show that OMP can also interact with other adenosine nucleotides as ATP, ADP and AMP with different affinities. Adenosine Diphosphate 98-101 olfactory marker protein Homo sapiens 35-38 33490644-5 2021 Amongst all, ATP showed the bell-shape affinity to OMP in the presence of cAMP; ADP and AMP showed fewer affinities to OMP than ATP. Adenosine Diphosphate 80-83 olfactory marker protein Homo sapiens 119-122 33372036-9 2021 The kinetic analysis shows the MYO15 motor domain has a moderate duty ratio (~ 0.5) and weak thermodynamic coupling between ADP and actin binding. Adenosine Diphosphate 124-127 myosin XVA Homo sapiens 31-36 31992110-8 2021 When activated with ADP or TRAP protamine at 80 microg/mL reduced aggregation, from 73.8 +- 29.4 U to 46.9 +- 21.1 U (p < .001) with ADP and from 126.4 +- 16.1 U to 94.9 +- 23.7 U (p < .01) with TRAP. Adenosine Diphosphate 136-139 TRAP Homo sapiens 27-31 33641653-8 2021 Mechanistically, we found that ADP could downregulate HIF1A in MDS clones through upregulation of VHL, P53 and MDM2, which is involved in two parallel pathways to downregulate HIF1A. Adenosine Diphosphate 31-34 MDM2 proto-oncogene Homo sapiens 111-115 31949019-6 2021 The differential effect of Btk inhibition in CLEC-2 relative to GPVI signalling is explained by the positive feedback role involving Btk itself, as well as ADP and thromboxane A2 mediated activation of P2Y12 and TP receptors, respectively. Adenosine Diphosphate 156-159 Bruton tyrosine kinase Homo sapiens 27-30 33839685-6 2021 However, this residue hinders glucose binding because its mutation to alanine converts the AncMsPFK enzyme into a specific ADP-GK. Adenosine Diphosphate 123-126 glycerol kinase Homo sapiens 127-129 33839685-10 2021 This situation differs from that described for specific ADP-GK enzymes, where each substrate independently causes a sequential domain closure, resulting in three conformational states (open, semiclosed, and closed). Adenosine Diphosphate 56-59 glycerol kinase Homo sapiens 60-62 33295873-4 2020 Here we report that calcium selectively affects the dynamics of the abundant metazoan ER Hsp70 chaperone BiP, by enhancing its affinity for ADP. Adenosine Diphosphate 140-143 heat shock protein family A (Hsp70) member 4 Homo sapiens 89-94 32880917-3 2020 Here, using a single-molecule approach, we show that compressed RecA nucleoprotein filaments can exist in two distinct interconvertible states depending on the presence of ADP in the monomer-monomer interface. Adenosine Diphosphate 172-175 RAD51 recombinase Homo sapiens 64-68