PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31665930-0	2022	Orlistat increases arsenite tolerance in THP-1 derived macrophages through the up-regulation of ABCA1.	arsenite	19-27	GLI family zinc finger 2	Homo sapiens	41-46
31616959-0	2019	Chronic exposure to submicromolar arsenite promotes the migration of human esophageal Het1A cells induced by heparin-binding EGF-like growth factor.	arsenite	34-42	heparin binding EGF like growth factor	Homo sapiens	109-147
31616959-3	2019	Here, we examined whether chronic arsenite (As(III)) exposure promotes cell migration induced by heparin-binding EGF-like growth factor (HB-EGF) in human esophageal immortalized Het1A cells.	arsenite	34-42	heparin binding EGF like growth factor	Homo sapiens	97-135
31616959-3	2019	Here, we examined whether chronic arsenite (As(III)) exposure promotes cell migration induced by heparin-binding EGF-like growth factor (HB-EGF) in human esophageal immortalized Het1A cells.	arsenite	34-42	heparin binding EGF like growth factor	Homo sapiens	137-143
31703097-9	2019	Overexpressed GFP-fused isoforms were found in cytoplasm, nucleoli and arsenite induced stress granules in human cells as previously reported for hENDOV 282.	arsenite	71-79	endonuclease V	Homo sapiens	146-152
32030632-0	2020	Arsenite Increases Linc-ROR in Human Bronchial Epithelial Cells that Can Be Inhibited by Antioxidant Factors.	arsenite	0-8	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	19-27
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	arsenite	166-174	AKT serine/threonine kinase 1	Homo sapiens	0-3
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	arsenite	166-174	glycogen synthase kinase 3 beta	Homo sapiens	33-42
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	arsenite	166-174	cyclin D1	Homo sapiens	43-52
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	arsenite	166-174	transcription elongation factor A like 1	Homo sapiens	54-57
31680960-0	2019	Akt Regulated Phosphorylation of GSK-3beta/Cyclin D1, p21 and p27 Contributes to Cell Proliferation Through Cell Cycle Progression From G1 to S/G2M Phase in Low-Dose Arsenite Exposed HaCat Cells.	arsenite	166-174	interferon alpha inducible protein 27	Homo sapiens	62-65
32030632-3	2020	However, whether long intergenic non-coding RNA, regulator of reprogramming (linc-ROR) is involved in arsenite-induced oxidative stress has not been explored.	arsenite	102-110	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	17-85
32030632-4	2020	In this study, we found that arsenite dose responsively increased the expression of linc-ROR in human bronchial epithelial (HBE) cells, along with elevated oxidative stress demonstrated by increased intracellular reactive oxygen species (ROS) and DNA damage, as well as decreased antioxidant glutathione and superoxide dismutase.	arsenite	29-37	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	84-92
32030632-5	2020	We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells.	arsenite	172-180	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
32030632-5	2020	We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells.	arsenite	172-180	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	245-253
32030632-5	2020	We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells.	arsenite	172-180	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	359-367
32030632-5	2020	We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells.	arsenite	209-217	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
32030632-5	2020	We further found that the pre-treatment with N-acetylcysteine, a widely used ROS scavenger, and the over-expression of antioxidant NRF2 protein, both significantly reduced arsenite-induced oxidative stress in arsenite-treated HBE cells, and the linc-ROR over-expression was also inhibited, suggesting that oxidative stress is a key factor for the increase of linc-ROR in arsenite-treated HBE cells.	arsenite	209-217	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
32030632-6	2020	Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair.	arsenite	61-69	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	110-118
32030632-6	2020	Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair.	arsenite	61-69	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	163-171
32030632-6	2020	Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair.	arsenite	175-183	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	110-118
32030632-6	2020	Moreover, our results of bio-informatic analysis showed that arsenite-induced oxidative stress might modulate linc-ROR expression via 3 genes and the up-regulated linc-ROR in arsenite-induced oxidative stress may get involved in cellular processes such as cellular stress response, RNA metabolism, and DNA repair.	arsenite	175-183	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	163-171
32030632-7	2020	Collectively, our study demonstrates that oxidative stress plays the key role in arsenite-induced over-expression of linc-ROR, and linc-ROR may be a new clue for exploring the mechanism of arsenite toxicity.	arsenite	81-89	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	117-125
31773452-0	2020	Long-term treatment with arsenite activates HER1 and HER2 through upregulating EGF, TGFalpha, and HSP90 in a human uroepithelial cell line.	arsenite	25-33	epidermal growth factor receptor	Homo sapiens	44-48
31646340-1	2020	Previous studies demonstrate that the heavy metal cadmium and the metalloid arsenite activate estrogen receptor-alpha in breast cancer cells by forming a high affinity complex with the ligand binding domain of the receptor and that environmentally relevant doses of cadmium have estrogen-like activity in vivo.	arsenite	76-84	estrogen receptor 1	Homo sapiens	94-117
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	progesterone receptor	Homo sapiens	99-120
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	growth regulating estrogen receptor binding 1	Homo sapiens	122-127
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	133-138
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	complement C3	Homo sapiens	182-195
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	197-202
31646340-3	2020	Similar to estrogens, exposure of ovariectomized animals to arsenite induced the expression of the progesterone receptor, GREB1, and c-fos in the mammary gland and the expression of complement C3, c-fos, and cyclin D1 in the uterus and the increase was blocked by the antiestrogen ICI-182,780.	arsenite	60-68	cyclin D1	Homo sapiens	208-217
31773452-0	2020	Long-term treatment with arsenite activates HER1 and HER2 through upregulating EGF, TGFalpha, and HSP90 in a human uroepithelial cell line.	arsenite	25-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
31773452-0	2020	Long-term treatment with arsenite activates HER1 and HER2 through upregulating EGF, TGFalpha, and HSP90 in a human uroepithelial cell line.	arsenite	25-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	98-103
31546213-4	2020	Here, we report that miR-122, the most enriched constitutive miRNA in the liver, induced cell protective autophagy in arsenite-exposed hepatocytes.	arsenite	118-126	microRNA 122	Homo sapiens	21-28
32014540-6	2020	Of note, arsenite suppressed focal adhesion kinase (FAK) activity, which in turn activated RhoA, leading to altered actin assembly through LIMK activation, and subsequent cofilin inactivation.	arsenite	9-17	protein tyrosine kinase 2	Homo sapiens	29-50
32014540-6	2020	Of note, arsenite suppressed focal adhesion kinase (FAK) activity, which in turn activated RhoA, leading to altered actin assembly through LIMK activation, and subsequent cofilin inactivation.	arsenite	9-17	protein tyrosine kinase 2	Homo sapiens	52-55
32014540-6	2020	Of note, arsenite suppressed focal adhesion kinase (FAK) activity, which in turn activated RhoA, leading to altered actin assembly through LIMK activation, and subsequent cofilin inactivation.	arsenite	9-17	ras homolog family member A	Homo sapiens	91-95
32014540-6	2020	Of note, arsenite suppressed focal adhesion kinase (FAK) activity, which in turn activated RhoA, leading to altered actin assembly through LIMK activation, and subsequent cofilin inactivation.	arsenite	9-17	LIM domain kinase 1	Homo sapiens	139-143
32014540-6	2020	Of note, arsenite suppressed focal adhesion kinase (FAK) activity, which in turn activated RhoA, leading to altered actin assembly through LIMK activation, and subsequent cofilin inactivation.	arsenite	9-17	cofilin 1	Homo sapiens	171-178
31599952-0	2020	Corrigendum to "miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells".	arsenite	71-79	microRNA 149	Homo sapiens	16-23
31599952-0	2020	Corrigendum to "miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells".	arsenite	71-79	MAF bZIP transcription factor A	Homo sapiens	47-51
31941719-10	2020	The dramatic anticipation of, sensitization to, the effects of arsenite caused by the IP3R or RyR agonists was accompanied by a parallel significant genotoxic response in the absence of detectable mitochondrial dysfunction and cytotoxicity.	arsenite	63-71	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-90
31941719-10	2020	The dramatic anticipation of, sensitization to, the effects of arsenite caused by the IP3R or RyR agonists was accompanied by a parallel significant genotoxic response in the absence of detectable mitochondrial dysfunction and cytotoxicity.	arsenite	63-71	ryanodine receptor 1	Homo sapiens	94-97
31941719-18	2020	Indeed, a brief exposure to nanomolar levels of arsenite produced maximal effects under conditions in which the [Ca2+]m was increased by IP3R or RyR agonists.	arsenite	48-56	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	137-141
31941719-18	2020	Indeed, a brief exposure to nanomolar levels of arsenite produced maximal effects under conditions in which the [Ca2+]m was increased by IP3R or RyR agonists.	arsenite	48-56	ryanodine receptor 1	Homo sapiens	145-148
31940135-6	2020	The ability of RPE cells to express Hsp70 upon experimental induction of cell stress, by arsenite, was analyzed by flow cytometry.	arsenite	89-97	heat shock 70 kDa protein 1	Canis lupus familiaris	36-41
31940135-10	2020	Arsenite-induced stress led to a time- and dose-dependent increase in Hsp70 expression in canine RPE cells in vitro.	arsenite	0-8	heat shock 70 kDa protein 1	Canis lupus familiaris	70-75
31940135-11	2020	In addition, leucinostatin, which enhanced heat shock factor-1-induced transcription from the heat shock promoter in DNAJB1-luc-O23 reporter cell line, also enhanced Hsp70 expression in arsenite-stressed RPE cells, in a dose-dependent fashion.	arsenite	186-194	heat shock 70 kDa protein 1	Canis lupus familiaris	166-171
31546213-9	2020	Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis.	arsenite	97-105	microRNA 122	Homo sapiens	43-50
31546213-9	2020	Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis.	arsenite	97-105	pyruvate kinase M1/2	Homo sapiens	51-55
31546213-9	2020	Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis.	arsenite	97-105	AKT serine/threonine kinase 1	Homo sapiens	126-129
31546213-9	2020	Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis.	arsenite	97-105	mechanistic target of rapamycin kinase	Homo sapiens	130-134
31546213-9	2020	Taken together, our findings show that the miR-122/PKM2 autophagy axis protects hepatocytes from arsenite stress via the PI3K/Akt/mTOR pathway; thus, miR-122 may be a potential candidate in the treatment of arseniasis.	arsenite	97-105	microRNA 122	Homo sapiens	150-157
31546213-5	2020	Arsenite exposure elevated miRNA-122 level and decreased the level of its target gene, PKM2.	arsenite	0-8	microRNA 122	Homo sapiens	27-36
31546213-5	2020	Arsenite exposure elevated miRNA-122 level and decreased the level of its target gene, PKM2.	arsenite	0-8	pyruvate kinase M1/2	Homo sapiens	87-91