PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33225149-4	2020	We hypothesized that by blocking the ability of CES1 to hydrolyze PG-Gs in monocytes/macrophages, the beneficial effects of anti-inflammatory prostaglandin D2-glyceryl ester (PGD2-G) could be augmented.	pg-gs	66-71	carboxylesterase 1	Homo sapiens	48-52
28539604-1	2017	Cyclooxygenase-2 catalyses the biosynthesis of prostaglandins from arachidonic acid but also the biosynthesis of prostaglandin glycerol esters (PG-Gs) from 2-arachidonoylglycerol.	pg-gs	144-149	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
29722963-2	2018	COX-2 also inactivates the endogenous cannabinoid (eCB) 2-arachidonoylglycerol (2-AG) via oxygenation of its arachidonic acid backbone to form a variety of prostaglandin glyceryl esters (PG-Gs).	pg-gs	187-192	prostaglandin-endoperoxide synthase 2	Mus musculus	0-5
29722963-4	2018	Here we show that 2-AG is metabolized in the brain of transgenic COX-2-overexpressing mice and mice treated with lipopolysaccharide to form multiple species of PG-Gs that are detectable only when monoacylglycerol lipase is concomitantly blocked.	pg-gs	160-165	monoglyceride lipase	Mus musculus	196-219
29722963-5	2018	Formation of these PG-Gs is prevented by acute pharmacological inhibition of COX-2.	pg-gs	19-24	prostaglandin-endoperoxide synthase 2	Mus musculus	77-82
29722963-6	2018	These data provide evidence that neuronal COX-2 is capable of oxygenating 2-AG to form a variety PG-Gs in vivo and support further investigation of the physiological functions of PG-Gs.	pg-gs	97-102	prostaglandin-endoperoxide synthase 2	Mus musculus	42-47
29722963-6	2018	These data provide evidence that neuronal COX-2 is capable of oxygenating 2-AG to form a variety PG-Gs in vivo and support further investigation of the physiological functions of PG-Gs.	pg-gs	179-184	prostaglandin-endoperoxide synthase 2	Mus musculus	42-47
28539604-7	2017	The identification of the PGE2-G/P2Y6 pair uncovers the signalling mode of PG-Gs as previously under-appreciated products of cyclooxygenase-2.	pg-gs	75-80	pyrimidinergic receptor P2Y6	Homo sapiens	33-37
28539604-7	2017	The identification of the PGE2-G/P2Y6 pair uncovers the signalling mode of PG-Gs as previously under-appreciated products of cyclooxygenase-2.	pg-gs	75-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	125-141
25301951-1	2014	Prostaglandin glycerol esters (PG-Gs) are produced as a result of the oxygenation of the endocannabinoid, 2-arachidonoylglycerol, by cyclooxygenase 2.	pg-gs	31-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	133-149
27245906-3	2016	A diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) is generated by the action of COX-2 (and downstream prostaglandin synthases) on 2-AG and AEA.	pg-gs	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
25301951-5	2014	Purified recombinant LYPLA2 hydrolyzed PG-Gs in the following order of activity: PGE2-G > PGF2alpha-G > PGD2-G; LYPLA2 hydrolyzed 1- but not 2-arachidonoylglycerol or arachidonoylethanolamide.	pg-gs	39-44	lysophospholipase 2	Homo sapiens	21-27
25301951-5	2014	Purified recombinant LYPLA2 hydrolyzed PG-Gs in the following order of activity: PGE2-G > PGF2alpha-G > PGD2-G; LYPLA2 hydrolyzed 1- but not 2-arachidonoylglycerol or arachidonoylethanolamide.	pg-gs	39-44	lysophospholipase 2	Homo sapiens	118-124
24083319-4	2013	Our previous study showed CES1 was partly responsible for the hydrolysis of 2-AG (50%) and prostaglandin glyceryl esters (PG-Gs) (80-95%) in human THP1 monocytes and macrophages.	pg-gs	122-127	carboxylesterase 1	Homo sapiens	26-30
24083319-4	2013	Our previous study showed CES1 was partly responsible for the hydrolysis of 2-AG (50%) and prostaglandin glyceryl esters (PG-Gs) (80-95%) in human THP1 monocytes and macrophages.	pg-gs	122-127	GLI family zinc finger 2	Homo sapiens	147-151
24083319-14	2013	This is the first report to document the expression of PPT1 in a human monocyte and macrophage cell line and to show PPT1 can hydrolyze the natural substrates 2-AG and PG-Gs.	pg-gs	168-173	palmitoyl-protein thioesterase 1	Homo sapiens	55-59
24083319-14	2013	This is the first report to document the expression of PPT1 in a human monocyte and macrophage cell line and to show PPT1 can hydrolyze the natural substrates 2-AG and PG-Gs.	pg-gs	168-173	palmitoyl-protein thioesterase 1	Homo sapiens	117-121
21049984-10	2010	Incubation of THP1 cell lysates with small-molecule inhibitors targeting CES1 (thieno[3,2-e][1]benzothiophene-4,5-dione or JZL184) significantly reduced lipid glyceryl ester hydrolase activities (40-50% for 2AG and 80-95% for PG-Gs).	pg-gs	226-231	GLI family zinc finger 2	Homo sapiens	14-18
21049984-4	2010	Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG.	pg-gs	183-188	carboxylesterase 1	Homo sapiens	47-51
21049984-10	2010	Incubation of THP1 cell lysates with small-molecule inhibitors targeting CES1 (thieno[3,2-e][1]benzothiophene-4,5-dione or JZL184) significantly reduced lipid glyceryl ester hydrolase activities (40-50% for 2AG and 80-95% for PG-Gs).	pg-gs	226-231	carboxylesterase 1	Homo sapiens	73-77
21049984-12	2010	These results suggested that CES1 is in part responsible for the hydrolysis of 2AG and PG-Gs in THP1 cells, although it did not rule out a role for other hydrolases, especially with regard to 2AG metabolism since a substantial portion of its hydrolysis was not inactivated by the inhibitors.	pg-gs	87-92	carboxylesterase 1	Homo sapiens	29-33
21049984-12	2010	These results suggested that CES1 is in part responsible for the hydrolysis of 2AG and PG-Gs in THP1 cells, although it did not rule out a role for other hydrolases, especially with regard to 2AG metabolism since a substantial portion of its hydrolysis was not inactivated by the inhibitors.	pg-gs	87-92	GLI family zinc finger 2	Homo sapiens	96-100
21049984-4	2010	Here, we determined if two human CES isoforms, CES1 and CES2, hydrolyze the endocannabinoids 2-arachidonoylglycerol (2AG) and anandamide (AEA), and two prostaglandin glyceryl esters (PG-Gs), which are formed by COX-mediated oxygenation of 2AG.	pg-gs	183-188	carboxylesterase 2	Homo sapiens	56-60
11447235-1	2001	Prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) are generated by the action of cyclooxygenase-2 on the endocannabinoids 2-arachidonylglycerol (2-AG) and arachidonylethanolamide, respectively.	pg-gs	31-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-126
17954230-3	2007	Through the action of COX-2 and downstream prostaglandin synthases, a diverse family of prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs) have been identified.	pg-gs	119-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
16484297-1	2006	The oxygenation of endogenous cannabinoids (eCBs) 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide by cyclooxygenase-2 (COX-2) produces novel types of prostanoids: prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs).	pg-gs	207-212	prostaglandin-endoperoxide synthase 2	Mus musculus	114-130
16484297-1	2006	The oxygenation of endogenous cannabinoids (eCBs) 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide by cyclooxygenase-2 (COX-2) produces novel types of prostanoids: prostaglandin glycerol esters (PG-Gs) and prostaglandin ethanolamides (PG-EAs).	pg-gs	207-212	prostaglandin-endoperoxide synthase 2	Mus musculus	132-137