PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9860899-9 1998 In other assays the same dechlorinated product mixtures demonstrated biologic activities similar to the nondechlorinated Aroclors, including the ability of PCB mixtures to stimulate insulin secretion and cause neutrophil activation. Aroclors 121-129 pyruvate carboxylase Mus musculus 156-159 9860899-10 1998 The data presented here establish that the biologic activities of commercial PCB mixtures are altered by microbial reductive dechlorination and that an assessment of their toxic potential requires an array of tests that include the different mechanisms associated with PCBs. Polychlorinated Biphenyls 269-273 pyruvate carboxylase Mus musculus 77-80 19406239-4 2009 Placentas from ART had significantly higher activities of the steroid metabolizing enzymes UDP-glucuronosyltransferase (UGT) and sulfotransferase (SULT), which in ICSI were also coupled with decreased activity of the steroid regenerating enzymes beta-glucuronidase (beta-G) and aryl sulfatase (AS). Steroids 62-69 glucuronidase, beta Mus musculus 266-272 30753845-8 2019 In PBMCs, exposure to these steroids resulted in the increase of mRNA and secreted protein levels of IL-1beta, TNFalpha, and IL-6 cytokines, as well as in the increase of INFgamma mRNA level, decrease of IL-2 mRNA level, increase of TGFbeta mRNA level, and decrease of IL-4 mRNA and IL-10 secreted protein levels. Steroids 28-36 interleukin 10 Homo sapiens 283-288 19406241-0 2009 Steroid production and excretion by the pregnant mouse, particularly in relation to pregnancies with fetuses deficient in Delta7-sterol reductase (Dhcr7), the enzyme associated with Smith-Lemli-Opitz syndrome. Steroids 0-7 7-dehydrocholesterol reductase Mus musculus 147-152 19406241-10 2009 In contrast, this study has shown that pregnant mice carrying dhcr7 deficient fetuses with relatively high DHC production had essentially undetectable maternal excretions of steroids with Delta(7)- and Delta(8)-unsaturation. Steroids 174-182 7-dehydrocholesterol reductase Mus musculus 62-67 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-55 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 8-15 31068816-5 2019 The function of the Sig-1R as a chaperone is regulated by synthetic and endogenous ligands, with some of these compounds being a steroids and acting as key endogenous modifiers of the actions of the Sig-1R. Steroids 129-137 sigma non-opioid intracellular receptor 1 Homo sapiens 20-26 31068816-6 2019 There are cases in the literature that exemplify the close relationship between the actions of steroids on the Sig-1R and the resulting negative or positive effects on ion channel function/abundance. Steroids 95-103 sigma non-opioid intracellular receptor 1 Homo sapiens 111-117 31068816-8 2019 The present review focuses on describing how the Sig-1R regulates the functional properties and the expression of some sodium, calcium, potassium, and TRP ion channels in the presence of steroids and the physiological consequences of these interplays at the cellular level are also discussed. Steroids 187-195 sigma non-opioid intracellular receptor 1 Homo sapiens 49-55 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-55 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 30399420-0 2019 Phase I/II Trial of a Combination of Anti-CD3/CD7 Immunotoxins for Steroid-Refractory Acute Graft-versus-Host Disease. Steroids 67-74 CD7 molecule Homo sapiens 46-49 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-54 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 8-15 19487245-10 2009 Because UGT2B15 and UGT2B17 inactivate steroid hormones by glucuronidation, the regulation of their genes by 17beta-estradiol may maintain steroid hormone homeostasis and prevent excessive estrogen signaling activity. Steroids 39-54 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 20-27 30706455-0 2019 Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma. Steroids 125-132 myristoylated alanine rich protein kinase C substrate Mus musculus 38-83 19702536-5 2009 Several drug-activated nuclear receptors including CAR, PXR, VDR, and GR recognize drug responsive elements within the 5" flanking promoter region of CYP2C genes to mediate the transcriptional upregulation of these genes in response to xenobiotics and steroids. Steroids 252-260 CXADR pseudogene 1 Homo sapiens 51-54 30706455-2 2019 However, the effects of therapeutic procedures targeting the phosphorylation site of MARCKS on steroid-resistant asthma and the mechanisms underlying such effects have not yet been investigated. Steroids 95-102 myristoylated alanine rich protein kinase C substrate Mus musculus 85-91 30706455-12 2019 CONCLUSIONS AND IMPLICATIONS: Our findings indicate that targeting MARCKS phosphorylation through MPS treatment may inhibit neutrophilic inflammation and relieve asthma symptoms, thereby highlighting its potential as a therapeutic agent for steroid-resistant asthma. Steroids 241-248 myristoylated alanine rich protein kinase C substrate Mus musculus 67-73 30689811-12 2019 This study shows that Drp1 level is regulated by cAMP and that its phosphorylation via protein kinase A (PKA) activation plays a decisive role in mitochondrial shaping by offering an optimal environment for steroid hormone biosynthesis in Leydig cells. Steroids 207-222 dynamin 1-like Rattus norvegicus 22-26 19282384-1 2009 The protein kinase C (PKC) signaling pathway plays integral roles in the expression of the steroidogenic acute regulatory (StAR) protein that regulates steroid biosynthesis in steroidogenic cells. Steroids 91-98 steroidogenic acute regulatory protein Mus musculus 123-127 30648648-0 2019 Redox regulation of hormone sensitive lipase: Potential role in the mechanism of MEHP-induced stimulation of basal steroid synthesis in MA-10 Leydig cells. Steroids 115-122 lipase, hormone sensitive Mus musculus 20-44 19551668-14 2009 CONCLUSIONS: NAC seems to have an additive effect to steroids in suppressing IL-1alpha levels in tear fluid and may be clinically advantageous in modulating corneal wound healing during the early postoperative period after LASEK. Steroids 53-61 interleukin 1 alpha Homo sapiens 77-86 19394356-5 2009 Subsequently, we showed that ovarian steroids inhibit pivotal genes in the caspase-dependent and caspase-independent pathways in laser-captured serotonin neurons including apoptosis activating factor (Apaf1), apoptosis-inducing factor (AIF) and second mitochondria-derived activator of caspases (Smac/Diablo). Steroids 37-45 diablo IAP-binding mitochondrial protein Homo sapiens 296-300 30192640-3 2019 Studies in sheep demonstrate that prenatal exposure to excess native steroids or endocrine-disrupting chemicals with steroidogenic activity, such as bisphenol A, results in postnatal development of numerous cardiometabolic perturbations, including insulin resistance, increased adiposity, altered adipocyte size and distribution, and hypertension. Steroids 69-77 LOC105613195 Ovis aries 248-255 30552902-1 2019 Stimulation of transient receptor potential M3 (TRPM3) channels with the steroid pregnenolone sulfate increases the transcriptional activation potential of Elk-1, a transcription factor that regulates serum response element-mediated transcription. Steroids 73-80 ETS transcription factor ELK1 Homo sapiens 156-161 30535412-6 2019 The effect of EGF, FGF2, HGF, and IGF-1 on steroid biosynthetic enzyme gene expression, including prostaglandin-endoperoxide synthase 2 (PTGS2), was determined by real-time PCR. Steroids 43-50 EGF Equus caballus 14-17 30535412-6 2019 The effect of EGF, FGF2, HGF, and IGF-1 on steroid biosynthetic enzyme gene expression, including prostaglandin-endoperoxide synthase 2 (PTGS2), was determined by real-time PCR. Steroids 43-50 hepatocyte growth factor Equus caballus 25-28 19394356-5 2009 Subsequently, we showed that ovarian steroids inhibit pivotal genes in the caspase-dependent and caspase-independent pathways in laser-captured serotonin neurons including apoptosis activating factor (Apaf1), apoptosis-inducing factor (AIF) and second mitochondria-derived activator of caspases (Smac/Diablo). Steroids 37-45 diablo IAP-binding mitochondrial protein Homo sapiens 301-307 19500372-11 2009 CONCLUSION: These results show that the expression of versican in uterine tissues is modulated by ovarian steroid hormones, in a tissue-specific manner. Steroids 106-122 versican Mus musculus 54-62 30372551-10 2019 Thus, NRDR has an important role in steroid hormone biosynthesis in cumulus granulosa cells, and NRDR SNPs are associated with changes in porcine reproduction traits. Steroids 36-51 dehydrogenase/reductase SDR family member 4 Sus scrofa 6-10 19446743-6 2009 Hp 1/1 genetic phenotype was associated with the risk for cervical cancer of steroid hormone ingestion: general risk odds ratio (OR)=5.388, P<0.001; for the interaction with carriers of Hp 1/1, OR=6.765, P<0.001; with carriers of Hp 2/1, OR=6.499, P<0.001; and with carriers of Hp 2/2, OR=3.903, P=0.001. Steroids 77-92 chromobox 5 Homo sapiens 0-6 31401629-3 2019 Intranasal steroids (INS) are effective in treating allergic rhinitis, but their effect on IL-25 release has not been studied. Steroids 11-19 interleukin 25 Homo sapiens 91-96 19446743-6 2009 Hp 1/1 genetic phenotype was associated with the risk for cervical cancer of steroid hormone ingestion: general risk odds ratio (OR)=5.388, P<0.001; for the interaction with carriers of Hp 1/1, OR=6.765, P<0.001; with carriers of Hp 2/1, OR=6.499, P<0.001; and with carriers of Hp 2/2, OR=3.903, P=0.001. Steroids 77-92 chromobox 5 Homo sapiens 189-195 19794290-2 2009 AIM: The aim of the present study was to investigate the effect of low and high doses of leptin on basal and FSH-induced steroids secretion by human luteinized granulosa cells in culture. Steroids 121-129 leptin Homo sapiens 89-95 30169894-0 2018 FKBP51 modulates steroid sensitivity and NFkappaB signalling: A novel anti-inflammatory drug target. Steroids 17-24 FK506 binding protein 5 Mus musculus 0-6 30169894-3 2018 The FK506-binding protein 51 (FKBP51) is reported to influence steroid sensitivity in mental disorders. Steroids 63-70 FK506 binding protein 5 Mus musculus 30-36 30169894-5 2018 The aim of this study was to elucidate whether FKBP51 inhibition had utility in modulating steroid resistant inflammation by increasing the sensitivity of the glucocorticoid receptor (GR) signalling and simultaneously inhibiting NFkappaB-driven inflammation. Steroids 91-98 FK506 binding protein 5 Mus musculus 47-53 19794290-5 2009 In particular, leptin at low concentrations stimulated the secretion of estradiol (1 and 10 ng/ml) and progesterone (10 ng/ml), while at a high concentration (100 ng/ml) it suppressed the secretion of both steroids. Steroids 206-214 leptin Homo sapiens 15-21 19794290-6 2009 A dose-related effect of leptin on FSH-induced steroidogenesis was not evident, since only the suppressive effect of the high concentration of leptin (100 ng/ml) reached statistical significance for both steroids. Steroids 204-212 leptin Homo sapiens 143-149 29709067-0 2018 The pathogenicity of IL-33 on steroid-resistant eosinophilic inflammation via the activation of memory-type ST2+ CD4+ T cells. Steroids 30-37 ST2 Homo sapiens 108-111 19794290-7 2009 CONCLUSIONS: These results demonstrate that leptin affects the secretion of steroids in luteinized granulosa cells in a dose-dependent manner. Steroids 76-84 leptin Homo sapiens 44-50 30072177-10 2018 Treatment with progesterone resulted in upregulation of NR1, NR2A, and NR3B which could explain a possible the neuroprotection of steroids via binding to NMDA glutamate receptor. Steroids 130-138 glutamate ionotropic receptor NMDA type subunit 2C Rattus norvegicus 154-177 19500762-4 2009 Defects of steroid 21-hydroxylase (CYP21A2) and 11beta-hydroxylase (CYP11B1) only affect adrenal steroidogenesis, whereas 17alpha-hydroxylase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase type 2 (HSD3B2) deficiency also impact on gonadal steroid biosynthesis. Steroids 11-18 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 35-42 30716803-9 2018 Conclusion:Post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor is effective in patients with sudden deafness with type 2 diabetesmellitus, furthermore, blood glucose will not be affected by the using of steroid, and it will aviod systemic hormonal side effects. Steroids 280-287 nerve growth factor Mus musculus 120-139 18328480-12 2009 4) ELISA reveals that MIS is secreted by human endometrial cells in vitro and that this process is increased by sex steroids. Steroids 116-124 anti-Mullerian hormone Homo sapiens 22-25 30356827-12 2018 HSD17B2 facilities metabolism of sex steroids. Steroids 37-45 hydroxysteroid 17-beta dehydrogenase 2 Canis lupus familiaris 0-7 30356827-15 2018 We speculate the identified SNP and HSD17B2 gene may have a role in the pathogenesis of elevated sex steroids and ALP in ST. Steroids 101-109 hydroxysteroid 17-beta dehydrogenase 2 Canis lupus familiaris 36-43 18983989-3 2009 By performing spectrophotometric analyses, we indicated that the enzymes CHCR1, CHCR2, and CHCR3 had similar specificities toward steroids; only CHCR3 did not show any reactivity with prostaglandins (PGs). Steroids 130-138 carbonyl reductase 1 Cricetulus griseus 73-78 29753162-9 2018 We analyzed CMV-specific immune reconstitution in the first 22 patients of the series and observed that patients on steroids had lower levels of CMV-specific lymphocytes TCD8 (P < .05 on days +60, +100, and +180) and that CMV-specific immune reconstitution (defined as lymphocytes CD8/IFN >= 1 cell/microL) was achieved later (after day +100 post-SCT) in the steroid group. Steroids 116-124 CD8a molecule Homo sapiens 284-291 29753162-9 2018 We analyzed CMV-specific immune reconstitution in the first 22 patients of the series and observed that patients on steroids had lower levels of CMV-specific lymphocytes TCD8 (P < .05 on days +60, +100, and +180) and that CMV-specific immune reconstitution (defined as lymphocytes CD8/IFN >= 1 cell/microL) was achieved later (after day +100 post-SCT) in the steroid group. Steroids 116-123 CD8a molecule Homo sapiens 284-291 19522186-1 2009 OBJECTIVE: To study the expression of Eotaxin and Eotaxin-2 in nasal polyp and observe the effects of steroids on Eotaxin and Eotaxin-2 in nasal polyps. Steroids 102-110 C-C motif chemokine ligand 24 Homo sapiens 126-135 29883615-1 2018 The purpose of this study was to identify the C11-oxy C19 and C11-oxy C21 steroids in male and female neonate plasma. Steroids 74-82 aldo-keto reductase family 1 member C4 Homo sapiens 62-73 29883615-2 2018 At birth, the most abundant C11-oxy steroids detected in neonatal plasma were 11beta-hydroxyandrostenedione, ~13 nM, and 11-ketoprogesterone, ~23 nM. Steroids 36-44 aldo-keto reductase family 1 member C4 Homo sapiens 28-31 19522186-5 2009 The steroids affected the expression of on Eotaxin-2 in mucosal epithelia of nasal polyps mostly. Steroids 4-12 C-C motif chemokine ligand 24 Homo sapiens 43-52 19522186-7 2009 2) The effects of steroid on the nasal polyps may depend on decreasing the infiltration of eosinophils and the expression of Eotaxin and Eotaxin-2. Steroids 18-25 C-C motif chemokine ligand 24 Homo sapiens 137-146 29883615-3 2018 C11-oxy C19 steroids were higher than C19 steroids in neonatal plasma, 22.2 nM vs 5.4 nM. Steroids 12-20 aldo-keto reductase family 1 member C4 Homo sapiens 0-11 19154806-9 2009 In overall, the correlation coefficients of cross-validation and prediction of the QSPR models resulted from MLR1, MLR2 and PCR1 approaches were higher than 90%, which show the high ability of the models to predict reduction potential of the studied steroids. Steroids 250-258 ligand dependent nuclear receptor corepressor like Homo sapiens 109-113 29883615-4 2018 The inclusion of C11-oxy C19 and C21 steroid reference ranges in routine steroid analyses will assist the characterization of disorders associated with impaired steroidogenic enzyme expression and the identification of potential biomarkers. Steroids 73-80 aldo-keto reductase family 1 member C4 Homo sapiens 17-28 30257454-8 2018 We found that chemerin and CMKLR1 protein levels were regulated in WAT by different conditions associated with metabolic changes such as nutritional status, sex steroids, pregnancy, and food composition. Steroids 161-169 retinoic acid receptor responder 2 Rattus norvegicus 14-22 18832096-1 2009 The enzyme P450c17 is required for glucocorticoid, sex steroid, and some neurosteroid biosynthesis. Steroids 55-62 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 11-18 30254311-7 2018 Site-1 protease inhibition is accompanied by a distinctive change in gene expression associated with amino acid, steroid and fatty acid synthesis pathways. Steroids 113-120 membrane bound transcription factor peptidase, site 1 Homo sapiens 0-15 19047579-10 2009 We conclude that antenatal steroid treatment results in the chronic alteration of ACE and ACE2 in the circulatory and tubular compartments, which may contribute to the higher blood pressure in this model of fetal programming-induced hypertension. Steroids 27-34 angiotensin-converting enzyme Ovis aries 82-85 30042117-4 2018 Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC, which is the underlying mechanism for positive- and negative feedback respectively, and it is now commonly accepted that the ARC kisspeptin neurons act as the GnRH pulse generator. Steroids 12-20 KiSS-1 metastasis-suppressor Mus musculus 31-41 30042117-4 2018 Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC, which is the underlying mechanism for positive- and negative feedback respectively, and it is now commonly accepted that the ARC kisspeptin neurons act as the GnRH pulse generator. Steroids 12-20 KiSS-1 metastasis-suppressor Mus musculus 75-85 30042117-4 2018 Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC, which is the underlying mechanism for positive- and negative feedback respectively, and it is now commonly accepted that the ARC kisspeptin neurons act as the GnRH pulse generator. Steroids 12-20 KiSS-1 metastasis-suppressor Mus musculus 75-85 19521113-2 2009 The successful adaptation to stress involves negative feedback at the level of the hypothalamic-pituitary-adrenal (HPA) axis provided by the glucocorticoid receptor (GR), which is a steroid-dependent transcription factor found in a heterocomplex with heat shock proteins Hsp90 and Hsp70. Steroids 182-189 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 281-286 30177118-5 2018 PATIENTS AND METHODS: Kallistatin level was estimated in 131 heart transplant recipients on standard 3 drugs immunosuppressive regimens (calcineurin inhibitor, mycophenolate mofetil/mycophenolic acid, and steroids) in correlation to inflammation markers and blood pressure values. Steroids 205-213 serpin family A member 4 Homo sapiens 22-33 18817822-6 2009 As in mammals, the fish KiSS1/GPR54 system appears to be partially regulated by gonadal steroids. Steroids 88-96 KISS1 receptor Homo sapiens 30-35 30154312-4 2018 Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). Steroids 51-66 growth regulating estrogen receptor binding 1 Homo sapiens 85-133 30154312-4 2018 Recent studies unearthed one potential mediator of steroid hormone action in tumors: growth regulation by estrogen in breast cancer 1 (GREB1). Steroids 51-66 growth regulating estrogen receptor binding 1 Homo sapiens 135-140 30154312-7 2018 Recent studies have shown that GREB1 also responds to progesterone in human endometrial cells, suggesting that GREB1 is a pan steroid-responsive gene. Steroids 126-133 growth regulating estrogen receptor binding 1 Homo sapiens 31-36 19210917-13 2009 We demonstrated in vivo that IL-1beta has an effect on steroids and PGF2alpha secretion in the preovulatory follicle. Steroids 55-63 interleukin-1 beta Equus caballus 29-37 30154312-7 2018 Recent studies have shown that GREB1 also responds to progesterone in human endometrial cells, suggesting that GREB1 is a pan steroid-responsive gene. Steroids 126-133 growth regulating estrogen receptor binding 1 Homo sapiens 111-116 29787826-8 2018 Taken together, we demonstrated that obesity induced miR-24 repressed HDL uptake, steroid hormone synthesis and lipid metabolism by targeting SR-B1. Steroids 82-97 scavenger receptor class B member 1 Homo sapiens 142-147 18834895-4 2008 To overcome this, the Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences (CDC/NCEH/DLS) initiated a project to standardize and to improve steroid hormone measurements. Steroids 205-220 neutral cholesterol ester hydrolase 1 Homo sapiens 145-149 30245919-16 2018 MiR-155 may play a role in mediating allergic inflammation in T-cells and could be an anti-inflammatory target of steroids. Steroids 114-122 microRNA 155 Homo sapiens 0-7 18716892-0 2008 Binding of estrogen receptor alpha promoter to nuclear proteins of mouse cerebral cortex: effect of age, sex, and gonadal steroids. Steroids 122-130 estrogen receptor 1 (alpha) Mus musculus 11-34 29772257-4 2018 In the MeA, as well as in the hypothalamus, Kiss1 mRNA expression mostly depends on sex steroids levels. Steroids 88-96 KiSS-1 metastasis-suppressor Mus musculus 44-49 18716892-1 2008 Majority of estrogen actions in the brain are mediated by estrogen receptor (ER) alpha which in turn is regulated by several factors like circulating levels of gonadal steroid hormones 17beta-estradiol and testosterone, sex and age of the organism. Steroids 168-184 estrogen receptor 1 (alpha) Mus musculus 58-86 18850725-9 2008 Two steroids, coeluting in GC1, were baseline separated in GC2 and resulted in delta(13)C VPDB values with average precisions of SD(delta(13)C) = 0.86 per thousand and average accuracies within 0.26 per thousand, at 3 ng on column. Steroids 4-12 solute carrier family 25 member 22 Homo sapiens 27-30 29716921-5 2018 In the initial DL1 (3 mg), 3 of 6 patients experienced grade 2-4 immune-related adverse events (IRAE) that were reversible with drug discontinuation and/or systemic steroids. Steroids 165-173 delta like canonical Notch ligand 1 Homo sapiens 15-18 19189646-4 2008 This steroid has been shown to bind to the farnesoid X receptor and modulate expression of proteins with antiapoptotic (IAP1, XIAP, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells. Steroids 5-12 BCL2 apoptosis regulator Bos taurus 142-147 29939161-1 2018 BACKGROUND: A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3beta-hydroxysteroid dehydrogenase 1 (3betaHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Steroids 202-210 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 41-47 29939161-1 2018 BACKGROUND: A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3beta-hydroxysteroid dehydrogenase 1 (3betaHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Steroids 202-210 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 86-122 18824694-4 2008 Phylogenetic footprinting and shadowing unveil conserved cis motifs, including an estrogen responsive element in the 5" promoter of LGALS1, that were gained during the emergence of placental mammals and could account for sex steroid regulation of LGALS1 expression, thus providing additional evidence for the role of galectin-1 in immune-endocrine cross-talk. Steroids 225-232 galectin 1 Homo sapiens 317-327 29939161-1 2018 BACKGROUND: A common germline variant in HSD3B1(1245A>C) encodes for a hyperactive 3beta-hydroxysteroid dehydrogenase 1 (3betaHSD1) missense that increases metabolic flux from extragonadal precursor steroids to DHT synthesis in prostate cancer. Steroids 202-210 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 124-133 29897975-1 2018 The translocator protein (TSPO) is an 18 kDa polytopic membrane protein of the outer mitochondrial membrane, abundantly present in the steroid-synthesising cells. Steroids 135-142 translocator protein Homo sapiens 4-24 29897975-1 2018 The translocator protein (TSPO) is an 18 kDa polytopic membrane protein of the outer mitochondrial membrane, abundantly present in the steroid-synthesising cells. Steroids 135-142 translocator protein Homo sapiens 26-30 18701461-4 2008 This pathway is critical for LH-induced steroid production in ovarian follicles, probably through matrix metalloproteinase (MMP)-mediated release of EGF receptor (EGFR) binding ectodomains. Steroids 40-47 epidermal growth factor receptor Mus musculus 149-161 29784791-6 2018 We delineate a pathway in which nutritional restriction increases levels of the steroid hormone ecdysone, which, in turn, triggers ecdysone signaling-dependent Imp-L2 production from the fat body, a fly adipose organ, thereby attenuating peripheral IIS and body growth. Steroids 80-95 Ecdysone-inducible gene L2 Drosophila melanogaster 160-166 18701461-4 2008 This pathway is critical for LH-induced steroid production in ovarian follicles, probably through matrix metalloproteinase (MMP)-mediated release of EGF receptor (EGFR) binding ectodomains. Steroids 40-47 epidermal growth factor receptor Mus musculus 163-167 18701461-6 2008 We demonstrated that, similar to the ovary, trans-activation of the EGF receptor was critical for gonadotropin-induced steroid production in Leydig cells. Steroids 119-126 epidermal growth factor receptor Mus musculus 68-80 18547287-11 2008 At w12, steroids decreased MUC5AC (from 40 to 5) and MUC5B (from 45 to 2.5) in NP-ATA patients" epithelium and glands, respectively, compared with baseline. Steroids 8-16 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 27-33 18414429-3 2008 We have previously demonstrated that T-bet, a key transcription factor directing T helper type 1 inflammatory responses, is regulated by female steroid hormones in human mucosal epithelial cells via Stat1 and 5 pathways. Steroids 144-160 T-box transcription factor 21 Homo sapiens 37-42 29217467-5 2018 In the circulation, vitamin D - like other steroid hormones - is bound tightly to a special carrier - vitamin D-binding protein (DBP). Steroids 43-59 GC vitamin D binding protein Homo sapiens 102-127 18628526-0 2008 Production of interleukin-1alpha by human endometrial stromal cells is triggered during menses and dysfunctional bleeding and is induced in culture by epithelial interleukin-1alpha released upon ovarian steroids withdrawal. Steroids 203-211 interleukin 1 alpha Homo sapiens 14-32 29417848-0 2018 Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1alpha in murine Leydig cells. Steroids 62-70 vascular endothelial growth factor A Mus musculus 28-32 29417848-13 2018 This suggested a mediatory role of steroids and HIF-1alpha protein in T3-stimulated VEGF secretion by MLTC-1 cells. Steroids 35-43 vascular endothelial growth factor A Mus musculus 84-88 29695968-5 2018 Among the ABC transporters, especially BCRP (ABCG2) and several MRP/ABCC subfamily members (MRP1, MRP4, MRP8) are expressed in the brain and known to efflux conjugated steroids. Steroids 168-176 ATP binding cassette subfamily C member 4 Homo sapiens 98-102 18628526-0 2008 Production of interleukin-1alpha by human endometrial stromal cells is triggered during menses and dysfunctional bleeding and is induced in culture by epithelial interleukin-1alpha released upon ovarian steroids withdrawal. Steroids 203-211 interleukin 1 alpha Homo sapiens 162-180 29695968-5 2018 Among the ABC transporters, especially BCRP (ABCG2) and several MRP/ABCC subfamily members (MRP1, MRP4, MRP8) are expressed in the brain and known to efflux conjugated steroids. Steroids 168-176 ATP binding cassette subfamily C member 11 Homo sapiens 104-108 18628526-2 2008 The paracrine induction of MMP-1 in stromal cells via epithelium-derived IL-1alpha is repressed by ovarian steroids. Steroids 107-115 matrix metallopeptidase 1 Homo sapiens 27-32 18628526-2 2008 The paracrine induction of MMP-1 in stromal cells via epithelium-derived IL-1alpha is repressed by ovarian steroids. Steroids 107-115 interleukin 1 alpha Homo sapiens 73-82 18785765-1 2008 Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) alpha and beta. Steroids 25-32 estrogen receptor 1 Rattus norvegicus 105-133 29534195-0 2018 Effects of Sex Steroids on the Spinal Gastrin-Releasing Peptide System Controlling Male Sexual Function in Rats. Steroids 15-23 gastrin releasing peptide Rattus norvegicus 38-63 29534195-2 2018 In contrast, in female rats, GRP neurons could scarcely be detected around puberty when circulating ovarian steroid hormones such as estradiol and progesterone levels are increasing. Steroids 108-124 gastrin releasing peptide Rattus norvegicus 29-32 29248731-2 2018 After reporting the steroid derivative PBRM as a first potent covalent inhibitor of 17beta-HSD1 without estrogenic activity, we are now interested in studying its pharmaceutical behavior. Steroids 20-27 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 84-95 18547992-7 2008 Both CD20(+) B cells and CD38(+) cells correlated with poor response of the rejection to steroids. Steroids 89-97 CD38 molecule Homo sapiens 25-29 18423938-3 2008 One of them derives from a Norrish I photoreaction which cleaves the C17-C20 bond of the steroid yielding the andro-derivative, a second product comes from a Yang-type photorearrangement which links C18 to C20 yielding a cyclobutane adduct. Steroids 89-96 cytokine like 1 Homo sapiens 69-72 29482121-0 2018 A high-throughput UPC2-MS/MS method for the separation and quantification of C19 and C21 steroids and their C11-oxy steroid metabolites in the classical, alternative, backdoor and 11OHA4 steroid pathways. Steroids 116-123 aldo-keto reductase family 1 member C4 Homo sapiens 108-111 29482121-7 2018 This is, to our knowledge, the first method reported to simultaneously separate C19 and C21 steroids, together with their C11-hydroxy and C11-keto metabolites -one which may hold promise in the identification of new steroid markers in steroid-linked endocrine diseases, in addition to profiling steroid metabolism and abnormal enzyme activity in patients. Steroids 216-223 aldo-keto reductase family 1 member C4 Homo sapiens 122-125 29482121-7 2018 This is, to our knowledge, the first method reported to simultaneously separate C19 and C21 steroids, together with their C11-hydroxy and C11-keto metabolites -one which may hold promise in the identification of new steroid markers in steroid-linked endocrine diseases, in addition to profiling steroid metabolism and abnormal enzyme activity in patients. Steroids 216-223 aldo-keto reductase family 1 member C4 Homo sapiens 138-141 29482121-7 2018 This is, to our knowledge, the first method reported to simultaneously separate C19 and C21 steroids, together with their C11-hydroxy and C11-keto metabolites -one which may hold promise in the identification of new steroid markers in steroid-linked endocrine diseases, in addition to profiling steroid metabolism and abnormal enzyme activity in patients. Steroids 216-223 aldo-keto reductase family 1 member C4 Homo sapiens 122-125 29482121-7 2018 This is, to our knowledge, the first method reported to simultaneously separate C19 and C21 steroids, together with their C11-hydroxy and C11-keto metabolites -one which may hold promise in the identification of new steroid markers in steroid-linked endocrine diseases, in addition to profiling steroid metabolism and abnormal enzyme activity in patients. Steroids 216-223 aldo-keto reductase family 1 member C4 Homo sapiens 138-141 18534255-1 2008 Vitamin D (VD), is a steroid hormone with multiple functions in the central nervous system (CNS), producing numerous physiological effects mediated by its receptor (VDR). Steroids 21-36 vitamin D receptor Rattus norvegicus 165-168 28982580-1 2018 Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). Steroids 98-105 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 222-247 18505830-5 2008 The expression of c-fos following such steroid treatment and mating in ovariectomized transgenics was similar to the expression previously reported in nontransgenic mice. Steroids 39-46 FBJ osteosarcoma oncogene Mus musculus 18-23 29414032-4 2018 Evidence suggests structural changes to mitochondrial translocator protein (TSPO) (a regulator of steroid synthesis) due to the single nucleotide polymorphism rs6971, may explain much of this variance. Steroids 98-105 translocator protein Homo sapiens 76-80 29515582-9 2018 In line with our hypothesis, we observed that triple maintenance immunosuppression (CNI + MMF + steroids) efficiently blocked activation-induced upregulation of CD25 on CD8+, but not on CD4+ T cells. Steroids 96-104 CD8a molecule Homo sapiens 169-172 18412286-13 2008 It is shown that patients with RPS19 mutations display a poorer response to steroids and a worse long-term prognosis compared to other DBA patients. Steroids 76-84 ribosomal protein S19 Homo sapiens 31-36 29128554-2 2018 Standard treatment is lacking for steroid-dependent/refractory cases; therefore, the potential usefulness of tyrosine kinase inhibitors (TKIs) has been suggested, based on their potent antifibrotic effect. Steroids 34-41 TXK tyrosine kinase Homo sapiens 109-124 18440126-5 2008 Immunohistochemical analyses suggest that PGRMC1 and SERBP1 promote differentiation, since the expression of these proteins increased in endometrial cells undergoing steroid-depended terminal differentiation. Steroids 166-173 progesterone receptor membrane component 1 Homo sapiens 42-48 28830748-1 2018 Leptin modulates all levels of the reproductive endocrine axis in mammals, and in turn, both leptin and the leptin receptor are regulated by sex steroids. Steroids 145-153 leptin receptor Salmo salar 108-123 18480904-4 2008 The experimental results allow for an instructive comparison with the enzymic processes, particularly those of the cyclases in steroid biosynthesis (i.e. lanosterol synthase). Steroids 127-134 lanosterol synthase Homo sapiens 154-173 29170164-8 2018 In cultured granulosa cells, recombinant KIRREL halved steroid secretion in basal state (P < 0.05). Steroids 55-62 kirre like nephrin family adhesion molecule 1 Bos taurus 41-47 18570058-8 2008 We found an increase in AT-III in men receiving E(2) which may be related to gonadal steroid withdrawal, but no significant differences in other inflammatory or clotting factor parameters. Steroids 85-92 serpin family C member 1 Homo sapiens 24-30 18202129-0 2008 Identification of KiSS-1 product kisspeptin and steroid-sensitive sexually dimorphic kisspeptin neurons in medaka (oryzias latipes). Steroids 48-55 kisspeptin 2 Oryzias latipes 85-95 18258681-12 2008 Our findings demonstrate that 1) blockade of preoptic/hypothalamic K(ATP) channels produces an acceleration of the GnRH pulse generator in a steroid-dependent manner and 2) E(2)+P stimulate Kir6.2 gene expression in the POA. Steroids 141-148 gonadotropin releasing hormone 1 Rattus norvegicus 115-119 18258681-13 2008 These observations are consistent with the hypothesis that the negative feedback actions of ovarian steroids on the GnRH pulse generator are mediated, in part, by their ability to up-regulate K(ATP) channel subunit expression in the POA. Steroids 100-108 gonadotropin releasing hormone 1 Rattus norvegicus 116-120 18400107-2 2008 Because EMP2 is differentially expressed in the various stages of the murine and human estrous cycle, we tested the hypothesis that the steroid hormones progesterone and estrogen influence EMP2 expression and localization. Steroids 136-152 epithelial membrane protein 2 Mus musculus 8-12 18947014-6 2008 The role of steroids in completely correcting deficient lipoprotein lipase activity is discussed. Steroids 12-20 lipoprotein lipase Homo sapiens 56-74 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 estrogen receptor 1 (alpha) Mus musculus 153-170 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 estrogen receptor 1 (alpha) Mus musculus 172-174 18003945-2 2008 Understanding the role and specific mechanisms of androgen action via the AR in the ovary has been limited by confusion on how to interpret results from pharmacological studies, because many androgens can be metabolized in vivo and in vitro to steroids that can also exert actions via the estrogen receptor (ESR). Steroids 244-252 estrogen receptor 1 (alpha) Mus musculus 308-311 18026150-1 2008 We report the results of a retrospective analysis in 27 pediatric patients who received low-dose MTX as the second-line treatment for steroid-refractory or -dependent acute and chronic GVHD. Steroids 134-141 metaxin 1 Homo sapiens 97-100 18026150-10 2008 Low-dose MTX was tolerable and effective for the steroid-refractory or -dependent GVHD in reducing the dose of steroid without increasing the risk of opportunistic infection. Steroids 49-56 metaxin 1 Homo sapiens 9-12 18026150-10 2008 Low-dose MTX was tolerable and effective for the steroid-refractory or -dependent GVHD in reducing the dose of steroid without increasing the risk of opportunistic infection. Steroids 111-118 metaxin 1 Homo sapiens 9-12 18249534-1 2008 Neuroactive steroids (dehydroepiandrosterone, pregnenolone) and their sulfates act as modulators of glutamate and gamma-aminobutyrate type A receptors in the brain The physiological ratio of these neuromodulators is maintained by two enzymes present in the brain, namely, steroid sulfatase (STS) and steroid sulfuryl transferase (SULT). Steroids 12-20 steroid sulfatase Homo sapiens 272-289 18626730-9 2008 CONCLUSIONS: Downregulation of CRYAA, SOD1, and TPI1, observed here after a short period of DEX-induced ocular hypertension, may be involved in the onset of neural damage in steroid-induced glaucoma. Steroids 174-181 crystallin, alpha A Rattus norvegicus 31-36 17728018-3 2008 This enzyme cleaves beta-amyloid precursor protein (betaAPP) to generate Abeta peptides, which are influenced by sex steroids. Steroids 117-125 amyloid beta (A4) precursor protein Mus musculus 20-50 17728018-3 2008 This enzyme cleaves beta-amyloid precursor protein (betaAPP) to generate Abeta peptides, which are influenced by sex steroids. Steroids 117-125 amyloid beta (A4) precursor protein Mus musculus 52-59 17728018-3 2008 This enzyme cleaves beta-amyloid precursor protein (betaAPP) to generate Abeta peptides, which are influenced by sex steroids. Steroids 117-125 amyloid beta (A4) precursor protein Mus musculus 73-78 17728018-4 2008 Recently we have reported the downregulation of PS1 expression by sex steroids in the brain of adult mice. Steroids 70-78 presenilin 1 Mus musculus 48-51 18197253-6 2008 By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein -a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Steroids 70-77 steroidogenic acute regulatory protein Mus musculus 131-161 18197253-6 2008 By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein -a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Steroids 70-77 steroidogenic acute regulatory protein Mus musculus 163-167 18497089-7 2008 MCF-7 cells cultured steroid-free additionally expressed CYP1A2 as well as UGT1A4, 1A8, and 1A9. Steroids 21-28 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 57-63 18497089-7 2008 MCF-7 cells cultured steroid-free additionally expressed CYP1A2 as well as UGT1A4, 1A8, and 1A9. Steroids 21-28 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 75-81 18180612-7 2008 Significant positive correlation between increased levels of IgG anti-beta2-GPI and increased IgG aCl serum concentrations was determined; these increased IgG concentrations significantly correlated with steroid therapy resistance. Steroids 204-211 apolipoprotein H Homo sapiens 70-79 17434649-7 2008 Furthermore, the C-17 spiro-epoxide analogues (ent-5 and ent-6) of ent-3 and ent-4, respectively, have activities comparable to those of steroids 1 and 2. Steroids 137-145 solute carrier family 29 member 4 Homo sapiens 77-82 18068102-0 2008 Leuprolide--a GnRH agonist--prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in mice. Steroids 88-95 gonadotropin releasing hormone 1 Mus musculus 14-18 19075542-2 2008 Moreover, the role of the precursor-product ratios of the steroids reflecting 11beta-HSD2 activity was estimated in 5 patients, including 3 patients reported previously by us. Steroids 58-66 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 78-89 18296905-9 2008 Data from this study show that PPARgamma and VEGFR-2 represent additional targets by which sex steroid estrogen and plant-derived phytoestrogens may, at certain doses, differentially regulate endometrial functions. Steroids 95-102 kinase insert domain receptor Rattus norvegicus 45-52 35147251-1 2022 PROBLEM: Interferon epsilon (IFNepsilon) is a unique type I IFN that is expressed in response to sex steroids. Steroids 101-109 interferon epsilon Homo sapiens 9-27 35147251-1 2022 PROBLEM: Interferon epsilon (IFNepsilon) is a unique type I IFN that is expressed in response to sex steroids. Steroids 101-109 interferon epsilon Homo sapiens 29-39 18360810-1 2008 The biosynthesis of steroids from steroidogenic cells are catalyzed by the two major enzymes, P450 side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD). Steroids 20-28 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Bos taurus 140-174 35432218-6 2022 Experimental and clinical evidence links BRCA1 with a number of peptide and steroid hormones. Steroids 76-83 BRCA1 DNA repair associated Homo sapiens 41-46 18360810-1 2008 The biosynthesis of steroids from steroidogenic cells are catalyzed by the two major enzymes, P450 side-chain cleavage enzyme (P450scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD). Steroids 20-28 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Bos taurus 176-185 19012073-1 2008 Stathmin, a steroid-responsive regulatory protein of oligodendrocyte migration and survival, is highly expressed in active brain lesions of patients with multiple sclerosis (MS) and probably involved in myelin degeneration and repair. Steroids 12-19 stathmin 1 Homo sapiens 0-8 19012073-2 2008 Here, we analyzed a single nucleotide polymorphism (rs182455) within the stathmin promoter that is close to a putative steroid-responsive element and has a high minor allelic frequency, in 647 clinically well characterized MS patients and 519 healthy controls. Steroids 119-126 stathmin 1 Homo sapiens 73-81 18667803-7 2008 On the neuronal side, steroid biotherapy increased brain-derived neurotrophic factor (BDNF) mRNA. Steroids 22-29 brain derived neurotrophic factor Mus musculus 51-84 35346673-0 2022 IL-17A Mediates Pyroptosis via ERK Pathway and Contributes to Steroid Resistance in CRSwNP. Steroids 62-69 interleukin 17A Homo sapiens 0-6 18667803-7 2008 On the neuronal side, steroid biotherapy increased brain-derived neurotrophic factor (BDNF) mRNA. Steroids 22-29 brain derived neurotrophic factor Mus musculus 86-90 35407383-0 2022 In BCR-ABL1 Positive B-Cell Acute Lymphoblastic Leukemia, Steroid Therapy Induces Hypofibrinogenemia. Steroids 58-65 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 7-11 35407383-5 2022 In univariate analysis, such a steroid-related HF was significantly associated with BCR-ABL1 rearrangement (p = 0.00158). Steroids 31-38 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 88-92 18086758-2 2007 We have genotyped nine putative functional single-nucleotide polymorphisms (SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 cases and 1,821 controls of Caucasian origin. Steroids 102-117 steroid 5 alpha-reductase 2 Homo sapiens 129-135 35407383-7 2022 Our retrospective study suggests that in B-ALL, steroid therapy can also induce HF and that such an event is preferentially observed in patients carrying BCR-ABL1 rearrangements. Steroids 48-55 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 158-162 17785913-1 2007 Transcription factor GATA-6 has been demonstrated to be expressed in the human fetal and adult adrenal cortex and has been postulated to play an important role in adrenal steroid biosynthesis. Steroids 171-178 GATA binding protein 6 Homo sapiens 0-27 35212793-3 2022 We aimed to (I) study the changes in the relative abundance of miR-205, miR-26a-5p, miR-17-5p, and let-7b-5p and their target genes: LHCGR, CASP3, PCNA, AMH, and PLA2G3, during different stages of corpus luteum in Egyptian buffaloes, and (II) and to address different scenarios between steroid concentrations in the serum and the expression pattern of selected miRNAs and their targets. Steroids 286-293 lutropin-choriogonadotropic hormone receptor Bos taurus 133-138 35173708-4 2021 Results: Firstly, compared with the steroid-sensitive nephrotic syndrome (SSNS) group (n=3), significant changes were observed in the mRNA level of 70 genes, including MAP3K14, CYBA, SLC3A2, CREB-binding protein (CREBBP), CD68, forkhead box P1 (FOXP1), CD74, ITGB2, IFI30, and so forth, in the SRNS group (n=3). Steroids 36-43 CD68 molecule Homo sapiens 222-226 17995524-2 2007 We and others observed that IgA itself could directly activate mesangial cells to produce monocyte chemotactic peptide-1 (MCP-1), interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) and this was suppressed by the treatment with steroid or angiotensin receptor blocker (ARB). Steroids 244-251 C-C motif chemokine ligand 2 Homo sapiens 90-120 17785682-13 2007 These effects strongly indicate that one major underlying mechanism for the endocrine-disrupting effects of azole fungicides is disturbance of key enzymes like CYP17 involved in the synthesis of steroid hormones. Steroids 195-211 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 160-165 35160139-4 2022 Moreover, non-steroid nuclear receptors, including the vitamin D receptor (VDR) and the thyroid receptors (TRs), are also present in breast cancers and have pathophysiologic implications. Steroids 14-21 vitamin D receptor Homo sapiens 55-73 35160139-4 2022 Moreover, non-steroid nuclear receptors, including the vitamin D receptor (VDR) and the thyroid receptors (TRs), are also present in breast cancers and have pathophysiologic implications. Steroids 14-21 vitamin D receptor Homo sapiens 75-78 18089358-5 2007 Steroid pulse therapy significantly reduced the expression of TLR-4 and TLR-2 on the monocytes of recipients with acute rejection. Steroids 0-7 toll like receptor 4 Homo sapiens 62-67 35221764-5 2022 She stopped topical steroid and was treated with topical application of benzoyl peroxide. Steroids 20-27 Src homology 2 domain containing E Homo sapiens 0-3 18089358-7 2007 The reduced expression of TLR-4 and TLR-2 may be one of the mechanisms by which steroid pulse therapy inhibits the development of acute rejection. Steroids 80-87 toll like receptor 4 Homo sapiens 26-31 18055602-4 2007 The transcript levels of the ZPR genes increase in response to activation of a steroid-inducible REV protein. Steroids 79-86 Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein Arabidopsis thaliana 97-100 35575922-3 2022 SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis. Steroids 141-148 scavenger receptor class B member 1 Homo sapiens 0-5 34121670-4 2022 She had immediate resolution of abdominal symptoms after initiation of steroid treatment, but the gastritis and gastric ulcers improved slowly and lasted for months as shown in endoscopy. Steroids 71-78 Src homology 2 domain containing E Homo sapiens 0-3 17666523-8 2007 Our study shows that ROR alpha and ROR gamma receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis. Steroids 157-165 RAR-related orphan receptor alpha Mus musculus 21-30 34121670-5 2022 She was finally treated with extended steroid therapy without serious complications. Steroids 38-45 Src homology 2 domain containing E Homo sapiens 0-3 17666523-8 2007 Our study shows that ROR alpha and ROR gamma receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis. Steroids 157-165 RAR-related orphan receptor alpha Mus musculus 212-216 2480959-2 1989 We report the isolating and sequencing of three cDNA clones encoding rat P-450scc, the nucleotide and protein sequences of which are highly homologous to those of bovine and human P-450scc, especially in the putative heme and steroid binding domains. Steroids 226-233 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 73-81 17890294-3 2007 Differences in steroid secretion are largely due to the expression of 21-hydroxylase (CYP21A1) and 11beta-hydroxylase (CYP11B1) activity in the adrenal. Steroids 15-22 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 70-84 2600976-3 1989 Similarly, neuritogenesis of cultured chick CNS neurons in medium supplemented with 20% fetal bovine serum is blocked by antibody to EGF, even though serum may contain other neuronotrophic bioactive proteins and steroids. Steroids 212-220 epidermal growth factor Gallus gallus 133-136 2557627-6 1989 This mutation causes a truncation of the VDR protein thereby deleting a large portion of the steroid hormone binding domain (amino acids 292-424). Steroids 93-108 vitamin D receptor Homo sapiens 41-44 17890294-3 2007 Differences in steroid secretion are largely due to the expression of 21-hydroxylase (CYP21A1) and 11beta-hydroxylase (CYP11B1) activity in the adrenal. Steroids 15-22 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 86-93 17410547-1 2007 Calbindin-D(9k) (CaBP-9k) gene is expressed in the uterus of pregnant rats, which is regulated by steroid hormones during estrous cycle or gestation. Steroids 98-114 S100 calcium binding protein G Rattus norvegicus 0-14 2554332-1 1989 During pregnancy the mouse uterine epithelial synthesis of the mononuclear phagocyte growth factor designated colony-stimulating factor 1 (CSF-1) is regulated by female sex steroids. Steroids 173-181 colony stimulating factor 1 (macrophage) Mus musculus 110-137 2554332-1 1989 During pregnancy the mouse uterine epithelial synthesis of the mononuclear phagocyte growth factor designated colony-stimulating factor 1 (CSF-1) is regulated by female sex steroids. Steroids 173-181 colony stimulating factor 1 (macrophage) Mus musculus 139-144 17586599-10 2007 Finally, the expression of protection of telomere 1 (POT1) induced resistance to the growth effect of steroid FG. Steroids 102-109 protection of telomeres 1 Homo sapiens 53-57 2803303-1 1989 Phosphorylation of chick progesterone receptor (PR) was attempted by incubating tissue minces from estrogen-primed oviducts with ortho [32P]phosphate in the absence and presence of different steroids. Steroids 191-199 progesterone receptor Gallus gallus 25-46 2803303-1 1989 Phosphorylation of chick progesterone receptor (PR) was attempted by incubating tissue minces from estrogen-primed oviducts with ortho [32P]phosphate in the absence and presence of different steroids. Steroids 191-199 progesterone receptor Gallus gallus 48-50 17889128-6 2007 Comparing the most recent evaluation with the data previous to steroid withdrawal, patients showed a significant decreases in diastolic pressure (P = .039), total cholesterol (P = .000), and low-density lipoprotein cholesterol levels (P = .039), but not in triglyceride levels (P = .33). Steroids 63-70 inhibitor of growth family member 1 Homo sapiens 278-285 2811360-3 1989 The ability to preserve the steroid-binding capacity of the glucocorticoid receptor is not a universal property of all sulfhydryl compounds since many of the compounds tested were inactive. Steroids 28-35 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 60-83 2811360-4 1989 The steroid-binding capacity of the glucocorticoid receptor of the 100,000 g supernatant of rat liver homogenate is preserved/restored by sulfhydryl compounds containing a mercaptoethylamine or mercaptopropylamine subunit. Steroids 4-11 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 36-59 17571860-7 2007 ChIP assays indicate that PR and NCoR each selectively localize to the enhancer element (PRE) of a transiently transfected PREtkLUC reporter in the presence of antagonist steroid, whereas exogenous TIF2.0 reduces the amount of PRE-associated NCoR. Steroids 171-178 nuclear receptor corepressor 1 Homo sapiens 33-37 2812273-8 1989 It is suggested that the proteins influenced by the Tfm mutation are regulated by steroids, most likely androgens. Steroids 82-90 androgen receptor Mus musculus 52-55 17623101-18 2007 CONCLUSION: The spatial and temporal expression of 17beta-HSD2 in the placenta during pregnancy and the comparison of 17beta-HSD2 expression and steroid levels between placental villi and endometrium are compatible with a role in the modulation of active and inactive forms of estrogens. Steroids 145-152 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 51-62 2488852-1 1989 The influence of 11 beta-phenyl substitution upon 4,9-dien-3-one steroid-backbone conformations is calculated by means of the MM2p molecular mechanics scheme. Steroids 65-72 PNMA family member 2 Homo sapiens 126-130 2770702-3 1989 Western blot analysis revealed that TCDD treatment did not cause a comparable decrease in the levels of immunodetectable receptor protein, which suggests that the steroid-binding properties of the hepatic GRc are altered, rather than the absolute concentration of receptor protein. Steroids 163-170 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 205-208 17446184-4 2007 Membranes prepared from both ovaries and mPRalpha-transfected cells showed high-affinity, saturable, displaceable, single binding sites specific for the goldfish maturation-inducing steroid, 17alpha,20beta-dihydroxy-4-pregnen-3-one (17,20beta-DHP). Steroids 182-189 S100 calcium binding protein A6 (calcyclin) Mus musculus 41-49 2507374-2 1989 Moreover, this steroid rapidly induces expression of the growth-related c-fos and c-myc protooncogenes. Steroids 15-22 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 72-77 17531295-8 2007 Individuals bearing FLG null alleles were more likely to be prescribed increased medication (chi(2) = 10.3; P = .001), with the homozygote null individuals having an odds ratio of 6.68 (95% CI, 1.7-27.0; P = .008) for being prescribed long-acting beta-agonists in addition to inhaled steroids. Steroids 284-292 filaggrin Homo sapiens 20-23 2785553-3 1989 After short-term in vivo steroid treatment, a significant decrease in the number and proportion of the CD4+/CD8+, double positive subpopulation was observed in parallel with a proportional increase in the percentage of the CD4+/CD8- single positive, of the CD4-/CD8-, double negative and, to a lesser extent, of the CD8+/CD4- subsets. Steroids 25-32 CD8a molecule Homo sapiens 108-111 2785553-3 1989 After short-term in vivo steroid treatment, a significant decrease in the number and proportion of the CD4+/CD8+, double positive subpopulation was observed in parallel with a proportional increase in the percentage of the CD4+/CD8- single positive, of the CD4-/CD8-, double negative and, to a lesser extent, of the CD8+/CD4- subsets. Steroids 25-32 CD8a molecule Homo sapiens 228-231 2785553-3 1989 After short-term in vivo steroid treatment, a significant decrease in the number and proportion of the CD4+/CD8+, double positive subpopulation was observed in parallel with a proportional increase in the percentage of the CD4+/CD8- single positive, of the CD4-/CD8-, double negative and, to a lesser extent, of the CD8+/CD4- subsets. Steroids 25-32 CD8a molecule Homo sapiens 228-231 2785553-3 1989 After short-term in vivo steroid treatment, a significant decrease in the number and proportion of the CD4+/CD8+, double positive subpopulation was observed in parallel with a proportional increase in the percentage of the CD4+/CD8- single positive, of the CD4-/CD8-, double negative and, to a lesser extent, of the CD8+/CD4- subsets. Steroids 25-32 CD8a molecule Homo sapiens 228-231 17601886-2 2007 The rate-limiting step in steroid hormone biosynthesis is the transport of substrate cholesterol from the outer to inner mitochondrial membrane by the steroidogenic acute regulatory protein (StAR). Steroids 26-41 steroidogenic acute regulatory protein Mus musculus 151-189 2568141-2 1989 The effect of steroid hormones on atrial natriuretic peptide (ANP)-stimulated cyclic guanosine monophosphate (cyclic GMP) formation was studied in cultured rat renal cells. Steroids 14-30 natriuretic peptide A Rattus norvegicus 34-60 17601886-2 2007 The rate-limiting step in steroid hormone biosynthesis is the transport of substrate cholesterol from the outer to inner mitochondrial membrane by the steroidogenic acute regulatory protein (StAR). Steroids 26-41 steroidogenic acute regulatory protein Mus musculus 191-195 2523242-3 1989 This co-localization supports the view that steroid hormones play an important role in the regulation of the CDD/ANP gene. Steroids 44-60 natriuretic peptide A Rattus norvegicus 109-116 17641097-1 2007 The prolactin (PRL) receptor antagonist S179D PRL delays the onset of maternal behavior in steroid-primed nulliparous female rats. Steroids 91-98 prolactin receptor Rattus norvegicus 4-28 17490617-9 2007 Steroid treatment was suggested to facilitate CD163-mediated endocytosis of hemoglobin to monocytes/macrophages and thereby induce acceleration of HO-1 synthesis. Steroids 0-7 heme oxygenase 1 Homo sapiens 147-151 2752532-4 1989 G6PD activity was stimulated by 1,25(OH)2D3 in a dose-dependent manner at very low concentrations of steroid (10(-10)-10(-12) M). Steroids 101-108 glucose-6-phosphate dehydrogenase Homo sapiens 0-4 17535872-12 2007 Together, these results indicate that ECM modulates basal and ACTH-induced cell functions, with FN, CI and CIV specifically favouring steroid secretion, as opposed to LN which inhibits secretion while promoting proliferation. Steroids 134-141 fibronectin 1 Rattus norvegicus 96-98 3244357-0 1988 Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action. Steroids 99-114 progesterone receptor Gallus gallus 13-34 17221218-5 2007 Overexpression of either the CCHCR1*WWCC risk allele or the non-risk allele enhanced steroid synthesis in vitro. Steroids 85-92 coiled-coil alpha-helical rod protein 1 Homo sapiens 29-35 2459497-7 1988 Potentiation of the antiangiogenic activity of steroids by HNT correlated inversely with the concentration of exogenous heparin. Steroids 47-55 neurotrimin Gallus gallus 59-62 2459497-13 1988 These results suggest that HNT (a) potentiates the anticoagulant function of heparin, (b) prevents the inactivation of antiangiogenic activity of heparin by an endogenous arylsulfatase in the chorioallantoic membrane and by a commercial arylsulfatase, and (c) in the presence of angiostatic steroids can inhibit angiogenesis in the chick embryo without the addition of exogenous heparin. Steroids 291-299 neurotrimin Gallus gallus 27-30 17221218-13 2007 Taken the role of steroid hormones, including vitamin D and estrogen, in cell proliferation, epidermal barrier homeostasis, differentiation, and immune response, our results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism. Steroids 18-25 coiled-coil alpha-helical rod protein 1 Homo sapiens 193-199 17221218-13 2007 Taken the role of steroid hormones, including vitamin D and estrogen, in cell proliferation, epidermal barrier homeostasis, differentiation, and immune response, our results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism. Steroids 260-267 coiled-coil alpha-helical rod protein 1 Homo sapiens 193-199 17479410-11 2007 Data indicate that MBP interfered with steroid hormone production by affecting StAR expression in MLTC-1 cells. Steroids 39-54 steroidogenic acute regulatory protein Mus musculus 79-83 3173639-5 1988 These results indicate that plasma gonadal steroids may regulate neurotensin receptors in the rat SCN. Steroids 43-51 neurotensin Rattus norvegicus 65-76 17403418-0 2007 Regulation of MMP-1 by sex steroid hormones in fibroblasts derived from the female pelvic floor. Steroids 27-43 matrix metallopeptidase 1 Homo sapiens 14-19 3285997-6 1988 CA125 inhibition is also dependent on the concentration of steroid used, with half-maximal and maximal inhibition by dexamethasone occurring at about 3 x 10(-9) M and 1 x 10(-7) M, respectively. Steroids 59-66 mucin 16, cell surface associated Homo sapiens 0-5 17403418-1 2007 OBJECTIVE: The aim of this study was to investigate the effect of sex steroid hormones on the overall expression profile of cellular matrix metalloproteinase-1 (MMP-1) in fibroblasts that are derived from arcus tendineus fasciae pelvis. Steroids 70-86 matrix metallopeptidase 1 Homo sapiens 133-159 17403418-1 2007 OBJECTIVE: The aim of this study was to investigate the effect of sex steroid hormones on the overall expression profile of cellular matrix metalloproteinase-1 (MMP-1) in fibroblasts that are derived from arcus tendineus fasciae pelvis. Steroids 70-86 matrix metallopeptidase 1 Homo sapiens 161-166 2967419-5 1988 The heritability index for variability of the plasma content of steroids was 45.4% (p less than .05) for total cortisol, 50.6% (P less than .05) for unbound plasma cortisol, 57.8% (P less than .05) for DHEA-S, and 32.4% (P greater than .05) for CBG. Steroids 64-72 sulfotransferase family 2A member 1 Homo sapiens 202-208 17068141-5 2007 Treatment with ovarian steroid hormones, trichostatin A, and SAHA enhanced cell migration together with up-regulation of glycodelin. Steroids 23-39 progestagen associated endometrial protein Homo sapiens 121-131 3360809-0 1988 Identification of hormone-interacting amino acid residues within the steroid-binding domain of the glucocorticoid receptor in relation to other steroid hormone receptors. Steroids 69-76 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 99-122 17293448-3 2007 Our previous data indicated that sexual steroids might affect late steps in GnRH signal transduction such as exocytosis. Steroids 40-48 gonadotropin releasing hormone 1 Mus musculus 76-80 2452093-10 1988 These results, as well as the variation of cholecystokinin during the estrous cycle, imply an important role for cholecystokinin in the regulation of steroid-initiated reproductive events. Steroids 150-157 cholecystokinin Rattus norvegicus 113-128 16955405-0 2007 Regulation of expression of the retinoic acid metabolizing enzyme CYP26A1 in uteri of ovariectomized mice after treatment with ovarian steroid hormones. Steroids 135-151 cytochrome P450, family 26, subfamily a, polypeptide 1 Mus musculus 66-73 3126035-14 1988 The presence of PR in gonadotrophs suggests a direct feedback mechanism of sex steroids on pituitary cells in addition to the indirect effect through GnRH modulation. Steroids 79-87 progesterone receptor Gallus gallus 16-18 3134505-9 1988 The results show that 3-hydroxysteroid UDP-glucuronosyltransferase, an enzyme specific for 3-hydroxyl groups of androgenic steroids and some conventional bile acids, also catalyzes the glucuronidation of 3 alpha-hydroxyl (but not carboxyl) groups of 3 alpha, 5 beta short-chain bile acids. Steroids 123-131 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 39-66 17196738-1 2007 Steroidogenic factor (SF1, NR5A1, Ad4BP) is an orphan nuclear receptor that is essential for steroid hormone-biosynthesis and endocrine development. Steroids 93-108 nuclear receptor subfamily 5 group A member 1 Homo sapiens 27-32 3374131-1 1988 The steroid binding properties of the human pancreatic estrogen binding protein (hEBP) in cytosol were studied by equilibrium dialysis. Steroids 4-11 EBP cholestenol delta-isomerase Homo sapiens 81-85 17196738-1 2007 Steroidogenic factor (SF1, NR5A1, Ad4BP) is an orphan nuclear receptor that is essential for steroid hormone-biosynthesis and endocrine development. Steroids 93-108 nuclear receptor subfamily 5 group A member 1 Homo sapiens 34-39 17935910-2 2007 BACKGROUND: UDP-glucuronosyltransferase (UGT) 2B17 is a phase II metabolizing enzyme that mediates the glucuronidation of C(19) steroids. Steroids 128-136 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 12-50 3362304-9 1988 Thus, the present findings support the hypothesis that levels of CCK within cells of these three sexually dimorphic cell groups are regulated by circulating gonadal steroids within a physiologically relevant time frame and may possibly contribute to the activation of female reproductive behavior as well as other neuroendocrine functions. Steroids 165-173 cholecystokinin Rattus norvegicus 65-68 17076760-2 2007 However, the presence, distribution and activity of cytochrome P450 17alpha-hydroxylase/C17, 20-lyase (P450(C17)), a key enzyme required for the conversion of pregnenolone (Delta(5)P) and progesterone (P) into these steroids, are poorly documented. Steroids 216-224 cytokine like 1 Homo sapiens 103-112 17050526-5 2006 Co-expression of Tspo, Pap7, PkarIalpha, and Star genes resulted in the stimulation of steroid formation in both steroidogenic MA-10 and non-steroidogenic COS-F2-130 cells that were engineered to metabolize cholesterol. Steroids 87-94 steroidogenic acute regulatory protein Mus musculus 45-49 3422744-2 1988 Purified modulator inhibits glucocorticoid-receptor complex activation and stabilizes the steroid-binding ability of the unoccupied glucocorticoid receptor. Steroids 90-97 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 132-155 16967287-8 2006 In steroid-dependence and secondary steroid-resistance, an increased frequency of HLA-DR3, DR7, DR3/7 and DQ2 was documented. Steroids 3-10 torsin family 1 member A Homo sapiens 106-109 16967287-8 2006 In steroid-dependence and secondary steroid-resistance, an increased frequency of HLA-DR3, DR7, DR3/7 and DQ2 was documented. Steroids 36-43 torsin family 1 member A Homo sapiens 106-109 3257409-0 1988 Effects of steroid hormones and peptide growth factors on protooncogene c-fos expression in human breast cancer cells. Steroids 11-27 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 72-77 17169280-0 2006 [Effect of tobacco smoking on leptin serum levels and its relationship with steroid hormones and bone mineral density]. Steroids 76-92 leptin Homo sapiens 30-36 17169280-3 2006 The aim of this study is to analyse the influence of tobacco on serum leptin levels, and its relationship with bone mineral density (BMD) and steroid hormones. Steroids 142-158 leptin Homo sapiens 70-76 3677084-2 1987 The antiinflammatory steroid fluocinolone acetonide, an inhibitor of TPA-induced hyperplasia, as well as the multiple stages of tumor promotion as defined in SENCAR mice (Stages I and II), inhibited the TPA-dependent elevation of epidermal XO activity. Steroids 21-28 xanthine dehydrogenase Mus musculus 240-242 16822832-4 2006 Using DNA microarray chips, we comprehensively identify the differences in genes expressed in basal and differentiating layers of the epidermis, including the ECM components produced by the basal cells, the proteases in both the basal and suprabasal cells, and the lipid and steroid metabolism enzymes in suprabasal cells responsible for the permeability barrier. Steroids 275-282 multimerin 1 Homo sapiens 159-162 3653035-1 1987 Previous studies have shown that steroid hormones reduce concentrations of nerve growth factor (NGF) in medium conditioned by L-929 fibroblasts (L cells). Steroids 33-49 nerve growth factor Mus musculus 75-94 3653035-1 1987 Previous studies have shown that steroid hormones reduce concentrations of nerve growth factor (NGF) in medium conditioned by L-929 fibroblasts (L cells). Steroids 33-49 nerve growth factor Mus musculus 96-99 16622173-9 2006 Steroid treatment decreased perlecan (by 24 +/- 3%, P < 0.01) and syndecan-1 expression (by 30 +/- 4%, P < 0.01) but increased the expression of decorin 2.5-fold. Steroids 0-7 syndecan 1 Rattus norvegicus 69-79 3661817-2 1987 During the use of steroids significant decreases (P less than 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P less than 0.001). Steroids 18-26 serpin family A member 7 Homo sapiens 185-217 3661817-2 1987 During the use of steroids significant decreases (P less than 0.05 to 0.001) in the serum concentrations of thyroid stimulating hormone, thyroxine, triidothyronine, free thyroxine, and thyroid hormone-binding globulin (TBG) were found, whereas the value of triidothyronine uptake increased (P less than 0.001). Steroids 18-26 serpin family A member 7 Homo sapiens 219-222 17018618-3 2006 In a comparative study of ANXA7 versus canonical tumor suppressor p53 effects on AA lipoxygenation pathway in the p53-mutant and androgen-insensitive DU145 prostate cancer cells, both tumor suppressors altered gene expression of major 5-lipoxygenase (LOX) and 15-LOXs, including response to T helper 2 (Th2)-cytokine [interleukin-4 (IL-4)] and endogenous steroids (mimicked by dexamethasone). Steroids 355-363 annexin A7 Homo sapiens 26-31 2441143-8 1987 5-20 mM sodium molybdate also shifted approximately 7 S to approximately 5 S. These results indicate that the approximately 7 S transformed form of the glucocorticoid receptor observed in low salt conditions might be an oligomer, probably including both approximately 5 S steroid-binding component and RNA/ribonucleoprotein, and that molybdate dissociates these interactions in a specific manner. Steroids 272-279 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 152-175 16720362-0 2006 Steroid hormone mediated regulation of corticotropin-releasing hormone gene expression. Steroids 0-15 corticotropin releasing hormone Homo sapiens 39-70 3108318-1 1987 The possibility that corticosteroid cytotoxicity could be mediated by activation of poly(ADP-ribose) polymerase and consequent depletion of NAD and ATP was evaluated in steroid-sensitive S49.1 and steroid-resistant S49.143R mouse lymphoma cells and in lymphocytes from a patient with chronic lymphocytic leukemia. Steroids 28-35 poly (ADP-ribose) polymerase family, member 1 Mus musculus 84-111 3108318-1 1987 The possibility that corticosteroid cytotoxicity could be mediated by activation of poly(ADP-ribose) polymerase and consequent depletion of NAD and ATP was evaluated in steroid-sensitive S49.1 and steroid-resistant S49.143R mouse lymphoma cells and in lymphocytes from a patient with chronic lymphocytic leukemia. Steroids 169-176 poly (ADP-ribose) polymerase family, member 1 Mus musculus 84-111 16720362-3 2006 Among various endogenous factors that modulate CRH production, steroid hormones control CRH production by regulating its gene transcription. Steroids 63-79 corticotropin releasing hormone Homo sapiens 88-91 16720362-4 2006 Although there is no classical steroid hormone response element in the CRH promoter, steroid hormones regulate CRH gene expression through protein-protein interaction or by binding directly to response elements. Steroids 85-101 corticotropin releasing hormone Homo sapiens 111-114 3495950-2 1987 Androgen receptors in Leydig cells had high affinity for [3H]methyltrienolone and steroid binding specificity typical of an androgen receptor. Steroids 82-89 androgen receptor Sus scrofa 124-141 16522749-4 2006 AIMS: To estimate the immunohistochemical expression of ezrin in children with MCD, DMP and focal segmental glomerulosclerosis (FSGS) and to evaluate its usefulness in predicting resistance to steroids. Steroids 193-201 ezrin Homo sapiens 56-61 3558388-2 1987 A 1-h incubation of hepatic cytosol with 1-3 M urea at 0 or at 23 degrees C caused a progressive decrease in the steroid binding efficiency of GR. Steroids 113-120 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 143-145 3552237-1 1987 Cell nuclei containing progesterone receptor were identified immunohistochemically in the hypothalamus and forebrain of the domestic hen using an antiserum to the steroid binding "B" subunit (110 kDa) of chicken oviduct progesterone receptor and the avidin-biotin complex procedure. Steroids 163-170 progesterone receptor Gallus gallus 23-44 16522749-11 2006 The increased permeability of the filtration barrier in steroid-resistant and proteinuric glomerulopathies may be a consequence of subcellular changes in podocyte-associated proteins following decreased expression of ezrin. Steroids 56-63 ezrin Homo sapiens 217-222 3029159-7 1987 The increases with E2 and T were reduced significantly by tamoxifen and cyproterone acetate, respectively, suggesting receptor mediation of the steroid effects. Steroids 144-151 cystatin 12, pseudogene Homo sapiens 19-27 16839691-2 2006 Therefore, the aim of the present study was to examine the role of endogenous and exogenous ovarian steroids in the induction of perseverative responses in a T-maze by the 5-HT1A agonist 8-OH-DPAT (1.0 and 2.0 mg/kg, SC) and in the preventive action of the selective serotonin reuptake inhibitor, fluoxetine (10.0 mg/kg, three times, SC). Steroids 100-108 5-hydroxytryptamine receptor 1A Homo sapiens 172-178 16806336-1 2006 Tibolone and its metabolites were evaluated on matrix metalloproteinase (MMP) expression in human endometrial stromal cells (HESCs) under the hypothesis that these steroids would act as progestins on MMP-1, -2, and -3 expression. Steroids 164-172 matrix metallopeptidase 1 Homo sapiens 200-217 3550806-5 1987 The results suggest that CCK levels within individual cells in each of the interconnected sexually dimorphic nuclei examined here are regulated by circulating gonadal steroids and may be related to the hormonal modulation of reproductive functions thought to be mediated by these cell groups. Steroids 167-175 cholecystokinin Rattus norvegicus 25-28 16788000-11 2006 However, complete inhibition of steroid synthesis with the gonadotropin-releasing hormone (GnRH) antagonist antide abrogated the increased response in propanil-treated mice, indicating a necessary role for steroid synthesis. Steroids 32-39 gonadotropin releasing hormone 1 Mus musculus 59-89 3105095-2 1987 One rat gene subfamily codes for at least four constitutive enzyme forms, including those which glucuronidate the androgenic steroids testosterone (UDPGTr-3) and androsterone (UDPGTr-4). Steroids 125-133 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 176-184 16788000-11 2006 However, complete inhibition of steroid synthesis with the gonadotropin-releasing hormone (GnRH) antagonist antide abrogated the increased response in propanil-treated mice, indicating a necessary role for steroid synthesis. Steroids 32-39 gonadotropin releasing hormone 1 Mus musculus 91-95 3604146-1 1987 A system (mobile phase) containing benzene:acetone:absolute ethanol 9:1:0.5, respectively, is described for thin-layer chromatography on Silufol plates of ligand receptors of sex steroid hormones 3H-5 alpha-androstan-3 beta, 17 beta-diol, 3H-estradiol-17 beta, 3H-5 alpha-dihydrotestosterone, 3H-methyltrienolone (R 1881), 3H-OPG 2058 and 3H-progesterone. Steroids 179-186 basic transcription factor 3 pseudogene 11 Homo sapiens 326-329 16788000-11 2006 However, complete inhibition of steroid synthesis with the gonadotropin-releasing hormone (GnRH) antagonist antide abrogated the increased response in propanil-treated mice, indicating a necessary role for steroid synthesis. Steroids 206-213 gonadotropin releasing hormone 1 Mus musculus 59-89 16788000-11 2006 However, complete inhibition of steroid synthesis with the gonadotropin-releasing hormone (GnRH) antagonist antide abrogated the increased response in propanil-treated mice, indicating a necessary role for steroid synthesis. Steroids 206-213 gonadotropin releasing hormone 1 Mus musculus 91-95 16687653-2 2006 We have previously demonstrated that several factors including interleukin-8, extracellular matrix, and steroid hormones modulate FASLG, one of the apoptotic molecules, in human endometrium. Steroids 104-111 Fas ligand Homo sapiens 130-135 3028264-7 1987 Subtle differences exist between the Ah receptor and the receptors for steroid hormones in response to a spectrum of sulfhydryl-modifying reagents, but the Ah receptor clearly contains a sulfhydryl group (or groups) essential for maintaining the receptor in a state in which it can bind ligands specifically and with high affinity. Steroids 71-87 aryl hydrocarbon receptor Rattus norvegicus 37-48 3677334-0 1987 Role of adrenal steroids in the recovery from platelet activating factor challenge. Steroids 16-24 PCNA clamp associated factor Rattus norvegicus 46-72 3677334-11 1987 Further, the efficacy of steroid pretreatment in shock models might involve, in part, the inhibition or reversal of PAF-induced cardiovascular alterations. Steroids 25-32 PCNA clamp associated factor Rattus norvegicus 116-119 16650473-3 2006 The modulation of ten major genes involved in the synthesis of steroid hormones (CYP11A, CYP11B2, CYP17, CYP19, 17betaHSD1, 17betaHSD4, CYP21, 3betaHSD2, HMGR, StAR) after exposure of H295R cells to sediment extracts was investigated using quantitative real-time polymerase chain reaction (PCR). Steroids 63-79 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 89-96 3445286-0 1986 Stereoselective reduction of C-2 substituted steroid C-3 ketones with lithium tris-(R,S-1,2-dimethylpropyl)-borohydride and sodium borohydride. Steroids 45-52 complement C3 Homo sapiens 53-56 3767382-11 1986 These results demonstrate that MEB is a unique sex-steroid binding protein, albeit of unknown function, which is distinct from hepatic steroid receptors. Steroids 51-58 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Homo sapiens 31-34 16911531-1 2006 The steroid hormone 20-hydroxyecdysone (20E) initiates insect molting and metamorphosis through binding with a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and ultraspiracle (USP). Steroids 4-19 protein ultraspiracle homolog Bombyx mori 196-199 16901926-1 2006 In the regulation of steroid biosynthesis, a process mediated by the steroidogenic acute regulatory (StAR) protein, both cAMP-dependent and -independent pathways are involved. Steroids 21-28 steroidogenic acute regulatory protein Mus musculus 101-105 3778686-0 1986 Serum histidine-rich glycoprotein levels are decreased in acquired immune deficiency syndrome and by steroid therapy. Steroids 101-108 histidine rich glycoprotein Homo sapiens 6-33 16901926-7 2006 Further characterization of signaling by one such cAMP-independent factor, TGFalpha, demonstrated that the mechanism, whereby it increased StAR expression and steroid synthesis, was dependent on de novo protein synthesis and mediated via activation of the EGF receptor. Steroids 159-166 transforming growth factor alpha Mus musculus 75-83 3778686-2 1986 Compared with controls (12.5 +/- 3.0 mg/dl), HRG levels were significantly decreased in patients with AIDS (5.7 +/- 1.8 mg/dl, P less than 0.005): in patients with ESRD after renal transplantation with steroid therapy (4.4 +/- 1.1 mg/dl, P less than 0.005); and in asthmatic and COPD patients receiving steroids in acute (7.6 +/- 2.9 mg/dl, P less than 0.005) or chronic (7.4 +/- 3.0 mg/dl, P less than 0.025) high-dose regimens. Steroids 202-209 histidine rich glycoprotein Homo sapiens 45-48 16901926-7 2006 Further characterization of signaling by one such cAMP-independent factor, TGFalpha, demonstrated that the mechanism, whereby it increased StAR expression and steroid synthesis, was dependent on de novo protein synthesis and mediated via activation of the EGF receptor. Steroids 159-166 epidermal growth factor Mus musculus 256-259 16132061-11 2006 This study demonstrated that: (i) low doses of cocaine induce a chemical state/memory trace sustaining StD; (ii) modulation of the sigma(1) receptor activation, although insufficient to provoke StD, modulates the cocaine state; (iii) neuroactive steroids exert a unique role in state-dependent vs state-independent learning, via GABA(A) or sigma(1) receptor modulation, and are able to affect the cocaine-induced mnesic trace at low brain concentrations. Steroids 246-254 sigma non-opioid intracellular receptor 1 Mus musculus 131-148 3020142-10 1986 In further experiments, it was also found that there were significant increases in cAMP as well as in steroid outputs above 1 nmol alpha MSH/l (highly significant above 10 nmol alpha-MSH/l). Steroids 102-109 proopiomelanocortin Rattus norvegicus 177-186 3020142-11 1986 There were plateaux of the outputs of both steroids and cAMP from 0.1 to 1 mumol alpha-MSH/l. Steroids 43-51 proopiomelanocortin Rattus norvegicus 81-90 16483614-0 2006 Aquaporin-2 expression in human endometrium correlates with serum ovarian steroid hormones. Steroids 74-90 aquaporin 2 Homo sapiens 0-11 2872084-10 1986 ANF inhibits aldosterone secretion from rat zona glomerulosa and steroid secretion by bovine adrenal zona glomerulosa and fasciculata. Steroids 65-72 natriuretic peptide A Rattus norvegicus 0-3 16483614-1 2006 The aim of the present study was to examine the expression of aquaporin-2 (AQP2), a member of the water channel family aquaporins (AQPs), in human uterine endometrium and its modulation of ovarian steroid hormone at the proliferative and secretory phases. Steroids 197-212 aquaporin 2 Homo sapiens 62-73 16483614-1 2006 The aim of the present study was to examine the expression of aquaporin-2 (AQP2), a member of the water channel family aquaporins (AQPs), in human uterine endometrium and its modulation of ovarian steroid hormone at the proliferative and secretory phases. Steroids 197-212 aquaporin 2 Homo sapiens 75-79 16987401-1 2006 Insulin-like growth factor-I (IGF-I) and thioredoxin are regulated by gonadal steroids in the female reproductive tract of many species. Steroids 78-86 thioredoxin Ovis aries 41-52 3707617-7 1986 At lower steroid levels, 3 more polar components (GP2, 3 and 4) were seen. Steroids 9-16 glycoprotein 2 Rattus norvegicus 50-62 16987401-10 2006 The transcripts of IGF-I, thioredoxin, ER alpha and PR, varied according to the physiological status and also along the female reproductive tract, suggesting that the regulation of the mRNA levels of these factors by the steroid environment is tissue specific. Steroids 221-228 thioredoxin Ovis aries 26-37 16787872-5 2006 ADAMTS13 activities returned to normal after steroid treatment, and the improvement of TMA symptoms followed. Steroids 45-52 ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens 0-8 3724140-0 1986 Steroid-bovine serum albumin conjugates: molecular characterization and their interaction with androgen and estrogen receptors. Steroids 0-7 albumin Rattus norvegicus 15-28 3707584-0 1986 Evidence for differences in the steroid binding domains of the glucocorticoid receptor versus the idiotype antibody. Steroids 32-39 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 63-86 16390864-13 2006 Whether GH and/or sex steroid administration alters local tissue production of IGFBPs and whether the latter influence autocrine or paracrine actions of IGF-I remain to be determined. Steroids 22-29 insulin like growth factor binding protein 1 Homo sapiens 79-85 16436532-11 2006 These results suggest that NGF may play important roles in action of steroids on uterine function. Steroids 69-77 Ngf Mesocricetus auratus 27-30 3963065-0 1986 Human ovarian oxytocin: its source and relationship to steroid hormones. Steroids 55-71 oxytocin/neurophysin I prepropeptide Homo sapiens 14-22 16712461-5 2006 The observation that GnRH receptors are expressed in steroid-dependent tumors, and that their activation reduces cell proliferation and metastatic behavior of cancer cell lines, both in vitro and in vivo (when inoculated into nude mice), indicates a possible additional and more direct antitumor activity for these compounds. Steroids 53-60 gonadotropin releasing hormone 1 Mus musculus 21-25 2938580-8 1986 On the other hand steroids may regulate ANF release and synthesis in the intact rat. Steroids 18-26 natriuretic peptide A Rattus norvegicus 40-43 16809239-4 2006 After inhaled steroid therapy, post-exercise TM levels were significantly decreased, but the increase in TM levels with exercise was also correlated with VEGF level (r = 0.60, p = 0.01). Steroids 14-21 thrombomodulin Homo sapiens 45-47 3486322-6 1986 Four steroids had an affinity for the glucocorticoid receptor higher than for the androgen receptor. Steroids 5-13 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 38-61 29445341-2 2018 Numerous studies have shown that Interleukin (IL)-17 producing CD4+T cells (Th17 cells), which could be inhibited by celastrol, is essential in mediating steroid-resistant AHR. Steroids 154-161 interleukin 17A Mus musculus 33-52 3486322-6 1986 Four steroids had an affinity for the glucocorticoid receptor higher than for the androgen receptor. Steroids 5-13 androgen receptor Rattus norvegicus 82-99 16809239-4 2006 After inhaled steroid therapy, post-exercise TM levels were significantly decreased, but the increase in TM levels with exercise was also correlated with VEGF level (r = 0.60, p = 0.01). Steroids 14-21 thrombomodulin Homo sapiens 105-107 29413517-6 2018 As TSPO effects on gene expression and on programmed cell death can be related to the wide range of functions that can be associated with TSPO, several of these five elements of Ca++, ROS, ATP, steroids, and tetrapyrroles may indeed form the basis of TSPO"s capability to operate as a multifunctional housekeeping gene to maintain homeostasis of the cell and of the whole multicellular organism. Steroids 194-202 translocator protein Homo sapiens 3-7 29413517-6 2018 As TSPO effects on gene expression and on programmed cell death can be related to the wide range of functions that can be associated with TSPO, several of these five elements of Ca++, ROS, ATP, steroids, and tetrapyrroles may indeed form the basis of TSPO"s capability to operate as a multifunctional housekeeping gene to maintain homeostasis of the cell and of the whole multicellular organism. Steroids 194-202 translocator protein Homo sapiens 138-142 3486322-7 1986 The assumption is made that the steroids tested also behave as antagonists when binding to the glucocorticoid receptor in muscle and behave as agonists when binding to the androgen receptor. Steroids 32-40 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 95-118 29413517-6 2018 As TSPO effects on gene expression and on programmed cell death can be related to the wide range of functions that can be associated with TSPO, several of these five elements of Ca++, ROS, ATP, steroids, and tetrapyrroles may indeed form the basis of TSPO"s capability to operate as a multifunctional housekeeping gene to maintain homeostasis of the cell and of the whole multicellular organism. Steroids 194-202 translocator protein Homo sapiens 138-142 3486322-7 1986 The assumption is made that the steroids tested also behave as antagonists when binding to the glucocorticoid receptor in muscle and behave as agonists when binding to the androgen receptor. Steroids 32-40 androgen receptor Rattus norvegicus 172-189 16423883-8 2006 This study demonstrates that the molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway, whereas fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated. Steroids 185-192 nuclear receptor coactivator 2 Mus musculus 54-59 3486322-9 1986 These indices might be of predictive value to determine whether these steroids exert their anabolic action in muscle through the glucocorticoid receptor or through the androgen receptor. Steroids 70-78 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 129-152 3954743-7 1986 Other subunits (Yk, Yn, Yb1 and Yb2) were inhibited more by lithocholate 3-sulphate than by lithocholate, indicating the existence of a significant ionic interaction, in the bile-acid-binding domain, between (an) amino acid residue(s) and the steroid ring A. Steroids 243-250 Y box binding protein 1 Rattus norvegicus 24-27 30205368-4 2018 Kisspeptin is a product of KISS1 gene that binds to a G-protein-coupled receptor (GPR54/KISS1R) stimulating the release of GnRH by hypothalamic neurons, leading to secretion of pituitary gonadotropins (LH and FSH) and sexual steroids, which in turn will act in the gonads to produce the gametes. Steroids 225-233 KiSS-1 metastasis suppressor Homo sapiens 27-32 28812264-1 2018 Biosynthesis and secretion of the hypothalamic nonapeptide oxytocin largely depends on steroid hormones. Steroids 87-103 oxytocin/neurophysin I prepropeptide Homo sapiens 59-67 28812264-5 2018 Oxytocin expressing neurons contain enzymes important for intrinsic steroid metabolism. Steroids 68-75 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 16244359-9 2006 Since AIB1 appears to modulate the effect of endogenous hormones via the estrogen receptor, and smoking affects circulating hormone levels, these results support evidence that steroid hormones play an important role in breast carcinogenesis in BRCA1 mutation carriers, and suggest mechanisms for developing novel cancer prevention strategies for BRCA1 mutation carriers. Steroids 176-192 nuclear receptor coactivator 3 Homo sapiens 6-10 29312493-2 2017 IL-17 is one of the pro-inflammatory cytokines produced by Th17 cells, and it plays an important role in the neutrophilic inflammation of airway in steroid-resistant asthmatics. Steroids 148-155 interleukin 17A Mus musculus 0-5 16514198-9 2006 These results are the first data showing that NRP-1, but not NRP-2, is expressed in the granulosa cells of bovine follicles and that NRP-1 gene expression is regulated by sex steroids. Steroids 175-183 neuropilin 1 Bos taurus 133-138 28956162-3 2017 Steroid hormone treatment of cultured explants showed that both Muc1 and Pr were significantly up-regulated (P < 0.05) by E2. Steroids 0-15 mucin 1, cell surface associated Rattus norvegicus 64-68 3543532-2 1986 In studies combining physicochemical separation methods with antibody methodology, we established that the molybdate-stabilised GR contains one steroid-binding monomer. Steroids 144-151 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 128-130 28389814-0 2017 Effect of tonsillectomy with steroid pulse therapy on circulating tumor necrosis factor receptors 1 and 2 in IgA nephropathy. Steroids 29-36 TNF receptor superfamily member 1B Homo sapiens 66-105 16497191-0 2006 The inhibitory effects of oxytocin on distal colonic contractile activity in rabbits are enhanced by ovarian steroids. Steroids 109-117 oxytocin Oryctolagus cuniculus 26-34 28389814-10 2017 In comparison with baseline TNFR levels, the levels of TNFR2, but not TNFR1, decreased significantly just before the third steroid pulse therapy, although both levels did not change after tonsillectomy. Steroids 123-130 TNF receptor superfamily member 1B Homo sapiens 55-60 28389814-11 2017 CONCLUSIONS: The TNFR2 level did not change after tonsillectomy alone but decreased significantly after steroid pulse therapy in patients with IgAN. Steroids 104-111 TNF receptor superfamily member 1B Homo sapiens 17-22 28405879-3 2017 THE AIMS OF OUR STUDY WERE: (1) to analyze pathological features and immunohistochemical expression of CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) in these tumors; (2) to investigate somatic mutations involved in adrenal steroid hypersecretion and/or tumor growth. Steroids 241-248 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 103-110 2419781-7 1986 These data suggest that certain CCK and SP neuronal systems may play a role in regulating the hypothalamo-pituitary-gonadal axis and/or be involved in steroid-dependent behavior. Steroids 151-158 cholecystokinin Rattus norvegicus 32-35 3024302-1 1986 The naturally occurring adrenal steroid, dehydroepiandrosterone (DHEA), is a potent non-competitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Steroids 32-39 glucose-6-phosphate dehydrogenase Homo sapiens 123-156 3024302-1 1986 The naturally occurring adrenal steroid, dehydroepiandrosterone (DHEA), is a potent non-competitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Steroids 32-39 glucose-6-phosphate dehydrogenase Homo sapiens 158-163 16497191-9 2006 CONCLUSION: These results suggest that oxytocin inhibits the contractile motility of the distal colon, which is regulated by Mg(2+) and ovarian steroids. Steroids 144-152 oxytocin Oryctolagus cuniculus 39-47 16628284-6 2006 Suppression of the basal secretion as well as the maximum concentration of cortisol (post-CRH) occurred during glucocorticoid therapy, which persisted for 48 hours after the steroid was removed from treatment (p< 0.01 and p< 0.0001, respectively, for the three tests). Steroids 174-181 corticotropin releasing hormone Homo sapiens 90-93 3865476-9 1985 This suggests that the alterations in kallikrein, aldosterone and PGE2 during cortisol excess in the present study were due to the mineralocorticoid potency of the steroid. Steroids 164-171 kallikrein related peptidase 4 Homo sapiens 38-48 29039554-9 2017 The present study indicated that miR may provide a novel and alternative approach for understanding the mechanism underlying steroid-associated necrosis of the femoral head. Steroids 125-132 myosin regulatory light chain interacting protein Rattus norvegicus 33-36 16307853-5 2006 Therefore, the aim of the present study was to better delineate the role of the mineralocorticoid receptor in steroid control of hearing in the autoimmune mouse. Steroids 110-117 nuclear receptor subfamily 3, group C, member 2 Mus musculus 80-106 29054730-1 2017 Translocator protein (TSPO) is an 18kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. Steroids 119-126 translocator protein Homo sapiens 0-20 29054730-1 2017 Translocator protein (TSPO) is an 18kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. Steroids 119-126 translocator protein Homo sapiens 22-26 3933508-0 1985 Cytochrome b5 promotes the synthesis of delta 16-C19 steroids by homogeneous cytochrome P-450 C21 side-chain cleavage from pig testis. Steroids 53-61 cytochrome b5 type A Sus scrofa 0-13 3933508-0 1985 Cytochrome b5 promotes the synthesis of delta 16-C19 steroids by homogeneous cytochrome P-450 C21 side-chain cleavage from pig testis. Steroids 53-61 cytochrome P450 family 21 subfamily A member 1 Sus scrofa 77-97 2932106-6 1985 Furthermore, the presence of steroids is necessary for the NaCl-stimulated ANF release. Steroids 29-37 natriuretic peptide A Rattus norvegicus 75-78 16307853-8 2006 This suggested both steroids are preserving hearing through the mineralocorticoid receptor within the ear to regulate endolymph homeostasis. Steroids 20-28 nuclear receptor subfamily 3, group C, member 2 Mus musculus 64-90 16307853-11 2006 It was concluded the inner ear mineralocorticoid receptor is a significant target of glucocorticoids and a factor that should be considered in therapeutic treatments for steroid-responsive hearing loss. Steroids 170-177 nuclear receptor subfamily 3, group C, member 2 Mus musculus 31-57 28782626-5 2017 Results derived from this study suggested a potential role of SULT2A1 as a Delta4-3-ketosteroid sulfotransferase in steroid metabolism. Steroids 88-95 sulfotransferase family 2A member 1 Homo sapiens 62-69 16459229-5 2006 Fecal excretion of neutral and acidic steroids in the PBF group was significantly higher than those in the BWP and casein groups. Steroids 38-46 PTTG1 interacting protein Rattus norvegicus 54-57 29259860-0 2017 Steroid-resistant nephrotic syndrome caused by co-inheritance of mutations at NPHS1 and ADCK4 genes in two Chinese siblings. Steroids 0-7 NPHS1 adhesion molecule, nephrin Homo sapiens 78-83 29259860-3 2017 We reported two siblings with steroid-resistant nephrotic syndrome caused by co-inheritance of mutations at NPHS1 (c.1339G>A, p.E447K) and ACDK4 (c.748G>C, p.D250H) genes. Steroids 30-37 NPHS1 adhesion molecule, nephrin Homo sapiens 108-113 4020434-3 1985 Cultured chromaffin cells were found to have a cytosolic, high affinity, saturable glucocorticoid-binding protein with the steroid specificity of a classical glucocorticoid receptor and a Kd of approximately 1 nM. Steroids 123-130 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 158-181 3930422-3 1985 The DCC assay with subsequent saturation analysis was used for the demonstration of specific cytoplasmatic binding sites of steroid hormones. Steroids 124-140 DCC netrin 1 receptor Homo sapiens 4-7 28774496-0 2017 Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. Steroids 20-28 aldo-keto reductase family 1 member C4 Homo sapiens 8-11 16280146-0 2006 Developmental changes of serum steroids produced by cytochrome P450c17 in rat. Steroids 31-39 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 52-70 28774496-0 2017 Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. Steroids 20-28 aldo-keto reductase family 1 member C4 Homo sapiens 47-50 28774496-0 2017 Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. Steroids 20-27 aldo-keto reductase family 1 member C4 Homo sapiens 8-11 28774496-0 2017 Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. Steroids 20-27 aldo-keto reductase family 1 member C4 Homo sapiens 47-50 27392637-3 2017 However, sulfated steroid hormones can actively be imported into specific target cells via uptake carriers, such as the sodium-dependent organic anion transporter SOAT, and, after hydrolysis by the steroid sulfatase (so-called sulfatase pathway), contribute to the overall regulation of steroid responsive organs. Steroids 18-34 solute carrier family 10 member 6 Homo sapiens 163-167 3930422-8 1985 Tyrosinase hydroxylates estradiol at the C2 level of the steroid. Steroids 57-64 tyrosinase Homo sapiens 0-10 3972844-11 1985 Our results indicate that rat liver glucocorticoid receptor is a phosphoprotein and that both the phosphorylated peptides 90K and 45K also contain the steroid and the DNA binding regions of the glucocorticoid receptor. Steroids 151-158 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 36-59 27392637-3 2017 However, sulfated steroid hormones can actively be imported into specific target cells via uptake carriers, such as the sodium-dependent organic anion transporter SOAT, and, after hydrolysis by the steroid sulfatase (so-called sulfatase pathway), contribute to the overall regulation of steroid responsive organs. Steroids 18-25 solute carrier family 10 member 6 Homo sapiens 163-167 3972844-11 1985 Our results indicate that rat liver glucocorticoid receptor is a phosphoprotein and that both the phosphorylated peptides 90K and 45K also contain the steroid and the DNA binding regions of the glucocorticoid receptor. Steroids 151-158 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 194-217 16280146-4 2006 The observed decline in the serum levels of the steroids was directly proportional to the previously reported decrease in mRNA expression and enzyme activity of cytochrome P450c17 in the rat liver. Steroids 48-56 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 172-179 16168712-4 2006 The ability to induce specific tolerance to S-Ag would be desirable and allow patients to be weaned off of steroid therapy. Steroids 107-114 S-antigen visual arrestin Homo sapiens 44-48 6541509-9 1984 Importantly, X/X Sxr and X/Y mouse testes secreted the same total amount of steroids, although X/X Sxr mouse testes weigh 17 mg while X/Y mouse testes weigh 110 mg. Histological studies established an increase in the relative mass of Leydig cells and the complete absence of germ cells in X/X Sxr mouse testes. Steroids 76-84 transposition, Chr Y, Cattanach 1 Mus musculus 17-20 6236850-1 1984 The effects of the anabolic steroid stanozolol (17-methyl-2H-5 alpha-androst-2-eno-(3,2-c)pyrazol-17 beta-ol) on lecithin-cholesterol acyltransferase, apolipoproteins B and D and the Lp(a) lipoprotein were determined in a prospective study of ten normolipidemic women with postmenopausal osteoporosis. Steroids 28-35 lecithin-cholesterol acyltransferase Homo sapiens 113-149 6746641-2 1984 The crystal structure of the dimeric steroid metabolizing enzyme, delta 5-3-ketosteroid isomerase (EC 5.3.3.1), has been solved to 6-A resolution by multiple isomorphous replacement, augmented by real space direct methods. Steroids 37-44 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 66-97 28830352-7 2017 We also detected decreased expression of several IFN-signature genes Ifit3 and Isg15 in CD4+ from SLE-prone mice following TOFA and DEXA treatment, and IFIT3 in CD3+ T cells from human patients following immunosuppressant therapy including steroid, respectively. Steroids 240-247 CD4 antigen Mus musculus 88-91 28743513-1 2017 Several studies have suggested that propiconazole (PROP) may be an endocrine disruptor; possibly altering the activity of the CYP51 enzyme, which is part of the cholesterol biosynthesis pathway required for the production of sexual steroid hormones. Steroids 232-248 cytochrome P450, family 51 Rattus norvegicus 126-131 28822438-10 2017 Multivariate logistic regression analysis demonstrated a decreased mortality (OR=0.375, 95% confidence interval (CI): 0.188-0.749, P=0.005)and incidence of RDS (OR=0.697, 95% CI: 0.462-0.953, P=0.041) in SGA infants exposed to antenatal steroids. Steroids 237-245 peripherin 2 Homo sapiens 156-159 16556163-6 2006 The elevated leptin levels found in heart transplant recipients could be due to the result of steroid therapy. Steroids 94-101 leptin Homo sapiens 13-19 6726343-9 1984 Taken together, our findings indicate that the glucocorticoid receptor deficit in the Brattleboro rat probably represents a vasopressin-influenced defect in the synthesis or degradation of the receptor, whereas in the aged rat the deficit originates from loss of both receptor per neuron and the steroid-concentrating neurons themselves, and thus is most likely a permanent and pharmacologically insensitive deficit. Steroids 296-303 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 47-70 6705733-1 1984 The molecular and steroid hormone-binding properties of the calf uterine progesterone receptor and its interaction with nucleic acids were investigated. Steroids 18-33 progesterone receptor Bos taurus 73-94 16210373-0 2006 Female sex steroids increase adrenomedullin-induced vasodilation by increasing the expression of adrenomedullin2 receptor components in rat mesenteric artery. Steroids 11-19 adrenomedullin 2 Rattus norvegicus 97-112 6705733-10 1984 These data suggest that the progesterone receptor"s steroid-binding site is more readily inactivated by heat than is the DNA-binding site, and that nucleic acid binding induces a conformational change, which consequently restores the receptor"s progesterone-binding site to functional activity. Steroids 52-59 progesterone receptor Bos taurus 28-49 6420404-8 1984 Both cytochromes P-450f and P-450h catalyze the hydroxylation of testosterone at the 16 alpha-position; however, cytochrome P-450h also oxidizes the steroid at the 2 alpha- and 17 beta-position (androstenedione formation). Steroids 149-156 cytochrome P450, family 2, subfamily c, polypeptide 7 Rattus norvegicus 17-23 17525483-12 2006 An immunohistochemical evaluation of adrenal 4 binding protein (Ad4BP) or SF-1, a transcription factor of all steroidogenesis, can aid in this differential diagnosis because nuclear immunoreactivity for this transcription factor is relatively specific to steroid producing cells. Steroids 110-117 nuclear receptor subfamily 5 group A member 1 Homo sapiens 37-62 6542536-0 1984 Changes of AChE activity in ovarian nerves of pigs in different periods of the oestrous cycle: relationship to ovarian steroids. Steroids 119-127 acetylcholinesterase Sus scrofa 11-15 6542536-5 1984 These results suggest that there exists a relationship between AChE activity in the ovary and ovarian steroid hormones and that this may be an important factor regulating the ovarian blood flow in the course of oestrous cycle in pigs. Steroids 102-118 acetylcholinesterase Sus scrofa 63-67 6322821-5 1983 T values resulted higher than Tc thus stressing the high degree of cross-reactivity among DHT, DHEAS, A and T in unchromatographed serum steroid RIA. Steroids 137-144 sulfotransferase family 2A member 1 Homo sapiens 95-100 17525483-12 2006 An immunohistochemical evaluation of adrenal 4 binding protein (Ad4BP) or SF-1, a transcription factor of all steroidogenesis, can aid in this differential diagnosis because nuclear immunoreactivity for this transcription factor is relatively specific to steroid producing cells. Steroids 110-117 nuclear receptor subfamily 5 group A member 1 Homo sapiens 64-69 16610357-3 2006 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids 100-107 heat shock protein 90 alpha family class A member 1 Homo sapiens 10-15 6646237-1 1983 In the chicken oviduct, it has been well documented that steroid hormones stimulate the transcription of specific genes such as the ovalbumin gene. Steroids 57-73 ovalbumin (SERPINB14) Gallus gallus 132-141 16610357-3 2006 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids 135-142 heat shock protein 90 alpha family class A member 1 Homo sapiens 10-15 16610357-3 2006 During GR-hsp90 heterocomplex assembly, the hydrophobic ligand-binding cleft is opened to access by steroid, and subsequent binding of steroid within the cleft triggers a transformation of the receptor such that it engages in more dynamic cycles of assembly/disassembly with hsp90 that are required for rapid dynein-dependent translocation to the nucleus. Steroids 135-142 heat shock protein 90 alpha family class A member 1 Homo sapiens 275-280 16325844-2 2006 Human patients with inflammatory bowel disease (IBD) who fail to respond to treatment with steroids express high levels of p-gp in lamina propria lymphocytes. Steroids 91-99 phosphoglycolate phosphatase Homo sapiens 123-127 6313672-1 1983 To study the regulation of expression of the chicken ovalbumin gene by steroid hormones, the entire ovalbumin gene and its flanking sequences were cloned together with the bacterial gene for xanthine-guanine phosphoribosyltransferase in plasmid pBR322. Steroids 71-87 ovalbumin (SERPINB14) Gallus gallus 53-62 16325844-8 2006 A low p-gp score before initiation of steroid treatment was significantly associated with a positive response to treatment (P=0.01). Steroids 38-45 PGP Canis lupus familiaris 6-10 6307658-2 1983 One of the ways to study Type I receptors isolated from Type II receptors is to block the latter with a steroid which shows high affinity for the glucocorticoid receptor and low affinity for the mineralocorticoid receptor. Steroids 104-111 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 146-169 17294649-5 2006 The foremost 40 genes for both the highest and the lowest expression levels involved endogenetic steroid and hormone metabolism, immune system, the leukocyte activity and inflammation, detoxification in liver, reproduction and growth hormone, regulation immune factors of anti-tumor and anti-infection and cancer to the mice sampled. Steroids 97-104 growth hormone Mus musculus 227-241 16648942-9 2006 Proximity of these non-coding polymorphisms to transcriptional regulatory elements (including potential sex steroid response elements) suggests a potential influence on the level of transcription of the SLC22A6 and/or SLC22A8 genes and will help define their role in variation in human drug, metabolite and toxin excretion. Steroids 108-115 solute carrier family 22 member 6 Homo sapiens 203-210 16648942-9 2006 Proximity of these non-coding polymorphisms to transcriptional regulatory elements (including potential sex steroid response elements) suggests a potential influence on the level of transcription of the SLC22A6 and/or SLC22A8 genes and will help define their role in variation in human drug, metabolite and toxin excretion. Steroids 108-115 solute carrier family 22 member 8 Homo sapiens 218-225 16401916-1 2006 OBJECTIVE: The primary aim was to evaluate the change in the total and free PSA levels after antibiotic and non-steroid anti-inflammatory treatment. Steroids 112-119 aminopeptidase puromycin sensitive Homo sapiens 76-79 16263717-0 2005 c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter. Steroids 109-116 MYB proto-oncogene, transcription factor Homo sapiens 0-5 16298471-1 2005 In the ovary, lutropin (LH) stimulates the selective uptake and transport of cholesterol for steroid biosynthesis from HDL particles via the scavenger receptor class B type I (SR-BI). Steroids 93-100 scavenger receptor class B, member 1 Rattus norvegicus 141-174 16298471-1 2005 In the ovary, lutropin (LH) stimulates the selective uptake and transport of cholesterol for steroid biosynthesis from HDL particles via the scavenger receptor class B type I (SR-BI). Steroids 93-100 scavenger receptor class B, member 1 Rattus norvegicus 176-181 16394248-2 2005 The recently characterized protein megalin, however, functions as a transport protein on cell surfaces to carry steroids across the plasma membrane. Steroids 112-120 low density lipoprotein receptor-related protein 2 Mus musculus 35-42 16394248-4 2005 Megalin-independent mechanisms of steroid uptake are likely important too, as the phenotypes of megalin-deficient mice do not completely mimic the phenotypes of androgen receptor- or estrogen receptor-null mice. Steroids 34-41 low density lipoprotein receptor-related protein 2 Mus musculus 0-7 16246455-1 2005 As a member of family of cytosolic calcium binding proteins, Calbindin-D9k (CaBP-9k) is expressed in female reproductive system and regulated by steroid hormones, estrogen (E2) and progesterone (P4), but its expression and role in pituitary gland have not been elucidated yet. Steroids 145-161 S100 calcium binding protein G Rattus norvegicus 61-74 16260720-9 2005 We present a model whereby steroid production may serve as one of many integrated signals triggered by EGFR signaling to promote oocyte maturation in gonadotropin-stimulated follicles. Steroids 27-34 epidermal growth factor receptor Mus musculus 103-107 16170380-3 2005 We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (PCa) specimens than adjacent noncancerous cells. Steroids 67-83 DNA polymerase delta 3, accessory subunit Homo sapiens 26-29 16821206-23 2005 However insulin, SHBG, sex steroids as well as age may also exert secondary influence on plasma leptin level in certain groups of women. Steroids 27-35 leptin Homo sapiens 96-102 16230520-11 2005 Fibrillin-1 deposition was doubled in the presence of female sex steroids (17beta-estradiol plus progesterone) compared with testosterone (P<0.01). Steroids 65-73 fibrillin 1 Homo sapiens 0-11 16107292-0 2005 Steroid-induced alterations in mRNA expression of the long form of the prolactin receptor in the medial preoptic area of female rats: Effects of exposure to a pregnancy-like regimen of progesterone and estradiol. Steroids 0-7 prolactin receptor Rattus norvegicus 71-89 16087666-9 2005 Thus, acetylation of hsp90 results in dynamic GR.hsp90 heterocomplex assembly/disassembly, and this is manifest in the cell as a approximately 100-fold shift to the right in the steroid dose response for gene activation. Steroids 178-185 heat shock protein 90 alpha family class A member 1 Homo sapiens 21-26 16087666-9 2005 Thus, acetylation of hsp90 results in dynamic GR.hsp90 heterocomplex assembly/disassembly, and this is manifest in the cell as a approximately 100-fold shift to the right in the steroid dose response for gene activation. Steroids 178-185 heat shock protein 90 alpha family class A member 1 Homo sapiens 49-54 15950994-0 2005 Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Steroids 11-18 carbonic anhydrase 1 Rattus norvegicus 86-89 16061484-4 2005 We reported previously that in the human uterus, a composite organ in which fibroblast, epithelial, and smooth muscle cells are the major constituents, an inverse relationship exists between the levels of PGF2alpha and a steroid-inducible anti-inflammatory protein, uteroglobin. Steroids 221-228 secretoglobin family 1A member 1 Homo sapiens 266-277 16081050-2 2005 INCICH-D7 has a heterocyclic ketoester type fusion between positions C14 and C17 of the steroid nucleus, which confers this molecule stronger electronegativity than that of digitoxigenin. Steroids 88-95 cytokine like 1 Homo sapiens 77-80 16126771-7 2005 In conclusion, our data implicate steroid hormones in the control of IGF system activities at the embryo-maternal interface, at least in part, through their effects on the post-translation changes of decidual-secreted IGFBP-1 such as its phosphorylation and/or proteolysis. Steroids 34-41 insulin like growth factor binding protein 1 Homo sapiens 218-225 16112913-11 2005 CYP3A38 preferentially catalyzed testosterone hydroxylation at the 6beta-, 2beta- and 16beta-positions with minor hydroxylation at other positions within the steroid nucleus. Steroids 158-165 cytochrome P450, family 3, subfamily A Oryzias latipes 0-5 16112913-13 2005 Putative identification of CYP3A substrate recognition sites (SRS) 1-6 indicates that 12 of the 49 amino acid differences between CYP3A38 and CYP3A40 OFRs occur in SRS regions previously known to be associated with steroid hydroxylation. Steroids 215-222 cytochrome P450, family 3, subfamily A Oryzias latipes 27-32 15956338-0 2005 Differential effects of sex steroid hormones on the expression of multiple first exons including a novel first exon of prolactin receptor gene in the rat liver. Steroids 28-44 prolactin receptor Rattus norvegicus 119-137 15956338-12 2005 These results indicated that the expression of the PRL-R gene in the liver is regulated by the differential effects of sex steroid hormones on the transcription of the multiple first exons including the novel one. Steroids 123-139 prolactin receptor Rattus norvegicus 51-56 15976146-10 2005 Gene expression changes indicate initiation of adipose tissue enlargement and the down-regulation of adipose steroid hormone biosynthesis. Steroids 109-124 WD and tetratricopeptide repeats 1 Mus musculus 101-108 15862830-4 2005 However, in rat enterocytes, both the 1,25D3-MARRS protein and the VDR play a role in the rapid, steroid-mediated uptake of phosphate or calcium. Steroids 97-104 vitamin D receptor Rattus norvegicus 67-70 15836953-10 2005 In animals with the ALK6 mutation, ovarian follicles undergo precocious maturation leading to three to seven follicles ovulating at smaller diameters without any increase above wild-types in the ovarian secretions of steroid or inhibin. Steroids 217-224 bone morphogenetic protein receptor type-1B Ovis aries 20-24 15850671-3 2005 Interestingly, the mechanisms by which neuroactive steroids exert their effects involve classical steroid receptors, like for instance progesterone and androgen receptors, in case of P0 and non-classical steroid receptors, like GABA(A) receptor, in case of PMP22. Steroids 51-59 peripheral myelin protein 22 Homo sapiens 257-262 15792648-9 2005 The application of MAb to VEGF during the periimplantation period, on the other hand, led to significant (p<.04) prevention of pregnancy without influencing steroid hormone levels in the circulation. Steroids 160-175 vascular endothelial growth factor A Macaca mulatta 26-30 15536167-4 2005 Our results revealed that SGK1 regulates gene expression of ENaC, whether cells are maintained in steroid-free media or in the presence of corticosteroids (CS) and/or other growth factors. Steroids 98-105 serum/glucocorticoid regulated kinase 1 Mus musculus 26-30 15536167-4 2005 Our results revealed that SGK1 regulates gene expression of ENaC, whether cells are maintained in steroid-free media or in the presence of corticosteroids (CS) and/or other growth factors. Steroids 98-105 sodium channel, nonvoltage-gated 1 alpha Mus musculus 60-64 15813602-2 2005 Mutations in the 5alpha-steroid reductase type 2 gene (SRD5A2) result in male pseudohermaphroditism caused by decreased dihydrotestosterone (DHT) synthesis--a key hormone of virilization of male external genitalia. Steroids 24-31 steroid 5 alpha-reductase 2 Homo sapiens 55-61 15635598-2 2005 Its role as a target for the rapid nongenomic effects of neuro(active)steroids and the age-related diminutions in steroid levels suggested that targeting the sigma1 receptor might allow alleviation of age-related neuronal dysfunctions. Steroids 70-78 sigma non-opioid intracellular receptor 1 Mus musculus 158-173 15635598-2 2005 Its role as a target for the rapid nongenomic effects of neuro(active)steroids and the age-related diminutions in steroid levels suggested that targeting the sigma1 receptor might allow alleviation of age-related neuronal dysfunctions. Steroids 70-77 sigma non-opioid intracellular receptor 1 Mus musculus 158-173 15546899-2 2005 We investigated the effect of gonadal steroids on the hormonal response to ovine CRH in women with (n = 5) and without (n = 7) a past history of postpartum depression (PPD) by creating an endocrine model of pregnancy and the postpartum. Steroids 38-46 corticotropin releasing hormone Homo sapiens 81-84 15747730-12 2005 BME-UV1 cells were much more responsive to the peptides, GH, STS, IGF-I and EGF, whereas MAC-T cells were more responsive to the steroid sex hormones: E2 and P4. Steroids 129-136 prostaglandin E receptor 4 Bos taurus 151-160 15695463-2 2005 Regulation of seed storage protein genes At2S3 and CRC by ABI3 and FUS3 was investigated using transgenic plants in which ABI3 and FUS3 could be ectopically induced by steroid hormones. Steroids 168-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 58-62 6574797-7 1983 The absence of TdT may correlate with other developmental characteristics of lymphoblasts, such as altered function or low numbers of glucocorticoid receptors or resistance to lysis by steroid drugs. Steroids 185-192 DNA nucleotidylexotransferase Homo sapiens 15-18 6853503-9 1983 After administration of a single dose of testosterone (10 mg) to female mice, an increased immunoreactive ornithine decarboxylase concentration was detected as soon as 2 h, and rose sharply between 8 and 24 h after steroid administration. Steroids 215-222 ornithine decarboxylase, structural 1 Mus musculus 106-129 6406926-3 1983 These results indicate that both the pineal gland and the SCN mediate the steroid-independent inhibition of pituitary gonadotropin release that occurs during exposure to short days. Steroids 74-81 sorcin Homo sapiens 58-61 6820382-0 1982 A unique change of steroid metabolism in rat liver microsomes induced with highly toxic polychlorinated biphenyl(PCB) and polychlorinated dibenzofuran(PCDF). Steroids 19-26 pyruvate carboxylase Rattus norvegicus 113-116 6891012-0 1982 Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. Steroids 205-212 androgen receptor Rattus norvegicus 109-126 6293509-7 1982 This order was surprising in view of the androgen receptor binding affinities of these steroids. Steroids 87-95 androgen receptor Rattus norvegicus 41-58 7096539-4 1982 The free glucocorticoid receptor-binding activity was determined by the extent to which steroids present in the sample inhibit binding of the 3H-labeled steroids. Steroids 88-96 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 9-32 7096539-4 1982 The free glucocorticoid receptor-binding activity was determined by the extent to which steroids present in the sample inhibit binding of the 3H-labeled steroids. Steroids 153-161 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 9-32 7132347-0 1982 Steroid-binding properties of the rat seminal vesicle androgen receptor: short-term and long-term competition of various steroids with radioactive dihydrotestosterone. Steroids 0-7 androgen receptor Rattus norvegicus 54-71 7132347-0 1982 Steroid-binding properties of the rat seminal vesicle androgen receptor: short-term and long-term competition of various steroids with radioactive dihydrotestosterone. Steroids 121-129 androgen receptor Rattus norvegicus 54-71 7132347-1 1982 Competition of 22 steroids with [3H]-dihydrotestosterone for the binding to the androgen receptor of the rat seminal vesicle has been studied. Steroids 18-26 androgen receptor Rattus norvegicus 80-97 6984237-4 1982 The sputum-to-serum ratio of alpha 1-antichymotrypsin, however, rose during steroid treatment with the result that there was a selective increase in this protease inhibitor, which may be of potential benefit to such patients. Steroids 76-83 serpin family A member 3 Homo sapiens 29-53 7173118-0 1982 Effect of transformed steroid compounds on mRNA synthesis and glucocorticoid-receptor interaction in the thymocytes of adrenalectomized rats. Steroids 22-29 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 62-85 6919568-1 1982 Urinary kallikrein is increased by restriction of dietary sodium and by administration of fludrocortisone, a sodium-retaining steroid. Steroids 126-133 kallikrein related peptidase 4 Homo sapiens 8-18 6919568-9 1982 Increased output of kallikrein in response to increased levels of sodium-retaining steroid may be a generalized response of organs that contain glandular kallikrein and can conserve sodium. Steroids 83-90 kallikrein related peptidase 4 Homo sapiens 20-30 6919568-9 1982 Increased output of kallikrein in response to increased levels of sodium-retaining steroid may be a generalized response of organs that contain glandular kallikrein and can conserve sodium. Steroids 83-90 kallikrein related peptidase 4 Homo sapiens 154-164 7157444-0 1982 C-3 glucosiduronates of metabolites of adrenal steroids. Steroids 47-55 complement C3 Homo sapiens 0-3 7109584-2 1982 Significant declines in the ratio of CE/C, cholesterol esterase (CEase) and acyl CoA:cholesterol acyl transferase (ACAT) activities occur during the peak and declining phases of adrenal and plasma corticosteroids, suggesting that when there is a decreased need for steroid precursors the amount of stored CE is decreased, and that the enzymes involved in CE metabolism decline in activity. Steroids 204-211 carboxyl ester lipase Rattus norvegicus 65-70 6282668-1 1982 The cytoplasmic glucocorticoid receptor of X. laevis liver has a high affinity for [3H]dexamethasone (Kd, 0.3 x 10(-8) M), and its binding specificity for a variety of steroids is similar to that found for mammalian glucocorticoid receptors. Steroids 168-176 nuclear receptor subfamily 3 group C member 1 S homeolog Xenopus laevis 16-39 6457907-4 1981 Among various halogenated steroids, 16 alpha-bromoepiandrosterone was 50 times as potent as dehydroepiandrosterone as an inhibitor of glucose-6-phosphate dehydrogenase. Steroids 26-34 glucose-6-phosphate dehydrogenase Homo sapiens 134-167 6113950-3 1981 We conclude that the steroidal inhibition of amino acid transport, at steroid concentrations of 10(-5) M or less is mediated by the same glucocorticoid receptor mechanisms as the induction of tyrosine aminotransferase. Steroids 21-28 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 137-160 7250045-0 1981 Interaction of steroids with dexamethasone-binding receptor and corticosteroid-binding globulin in the mammary gland of the mouse in relation to lactation. Steroids 15-23 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 64-95 7250045-10 1981 CBG in glands of lactating mice was saturated with endogenous steroids, but that in pregnant mice was only 8% saturated. Steroids 62-70 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 0-3 7297957-8 1981 Each of steroid hormones and amino acids tested induced a characteristic spectral change of methemoglobin or oxyhemoglobin. Steroids 8-24 hemoglobin subunit gamma 2 Homo sapiens 92-105 6261197-8 1981 Thus, serum DHEAS is a clinically useful indication of adrenal C-19 steroid secretion. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 12-17 7278996-2 1981 In the chicken oviduct the synthesis of the egg-white proteins ovalbumin, conalbumin, ovomucoid and lysozyme is controlled by the female sex steroids. Steroids 141-149 ovalbumin (SERPINB14) Gallus gallus 63-72 7278996-2 1981 In the chicken oviduct the synthesis of the egg-white proteins ovalbumin, conalbumin, ovomucoid and lysozyme is controlled by the female sex steroids. Steroids 141-149 serine peptidase inhibitor, Kazal type 7 (putative) Gallus gallus 86-95 6163790-6 1980 These results indicated that the steroid remained attached to the eluted AFP molecule. Steroids 33-40 alpha fetoprotein Mus musculus 73-76 6257282-7 1980 R0t analysis has demonstrated that, similar to the ovalbumin gene, the level of X and Y gene transcripts is increased by the steroid hormone estrogen, but to varying degrees. Steroids 125-140 ovalbumin (SERPINB14) Gallus gallus 51-60 6776357-0 1980 Oxidation of 3-oxygenated delta 4 and delta 5 - C27 steroids by soybean lipoxygenase and rat liver microsomes. Steroids 52-60 linoleate 9S-lipoxygenase-4 Glycine max 72-84 7426404-5 1980 Depletion of the activity of ornithine decarboxylase, the rate-limiting polyamine biosynthetic enzyme, by topical steroids was confirmed in the hairless mouse following induction of the enzyme by UV-B. Steroids 114-122 ornithine decarboxylase, structural 1 Mus musculus 29-52 6990402-2 1980 Enzymes and lipids furnishing synthesis of steroid hormones (3-beta-oxysteroid dehydrogenase, alcohol dehydrogenase, glucose-6-phosphate dehydrogenase. Steroids 43-59 aldo-keto reductase family 1 member A1 Homo sapiens 94-115 6990402-2 1980 Enzymes and lipids furnishing synthesis of steroid hormones (3-beta-oxysteroid dehydrogenase, alcohol dehydrogenase, glucose-6-phosphate dehydrogenase. Steroids 43-59 glucose-6-phosphate dehydrogenase Homo sapiens 117-150 7223149-2 1980 The incidence of RDS was found to be reduceable by half by administration of steroids to the mother. Steroids 77-85 peripherin 2 Homo sapiens 17-20 574038-6 1979 5 These results demonstrate that in lungs MAO-B activity was affected by endogenous changes in steroid level but that such changes in enzymic activity were not reflected in the metabolic properties of whole lung. Steroids 95-102 monoamine oxidase B Rattus norvegicus 42-47 156321-0 1979 Placental steroid synthesis from DHEAS during dexamethasone therapy. Steroids 10-17 sulfotransferase family 2A member 1 Homo sapiens 33-38 294766-4 1979 There was also a manifold increase in the activity of the enzyme G-6-PD in steroid-treated cells, and this increase in enzyme activity could be inhibited by addition of actinomycin D. Steroids 75-82 glucose-6-phosphate dehydrogenase Homo sapiens 65-71 386201-1 1979 Ligandin, a protein binding some carcinogens, steroids and other substances in the rat liver, has been found by means of indirect immunofluorescence in the gonad cells of different types: embryonic and mature Leidig cells in testes, ovarian thecal cells at the maturation stages (theca interna, atretic follicles and interstitial cells) and luteal cells of corpus luteum at pregnancy. Steroids 46-54 glutathione S-transferase alpha 2 Rattus norvegicus 0-8 743973-1 1978 Bombesin and other related peptides isolated from the skin of anuran species and found in mammalian brain stimulate PRL and GH release in steroid-primed male rats. Steroids 138-145 gastrin releasing peptide Homo sapiens 0-8 70291-2 1977 Subjects having a high serum-level of the glycoprotein (pregnant and contraceptive steroid-treated women) were shown to possess a significantly greater proportion of PAM-positive cells than those (normal males) with a low concentration. Steroids 83-90 peptidylglycine alpha-amidating monooxygenase Homo sapiens 166-169 189839-3 1977 Additional results suggest the existence of two forms of the activated glucocorticoid receptor-steroid complex in about equal amounts: one form binds only to nuclei and the other binds to DNA and nuclei. Steroids 95-102 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 71-94 189840-0 1977 Glucocorticoid receptor-steroid complex binding to DNA. Steroids 24-31 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 0-23 189840-2 1977 The binding of the glucocorticoid receptor-steroid complex from a line of rat hepatoma tissue culture (HTC) cells to DNA has been examined. Steroids 43-50 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 19-42 24814-7 1977 The effect of these steroids on the activity of the hypothalamic enzymes which yielded MIF or MRF upon incubation with oxytocin (OXT) was also studied. Steroids 20-28 myelin regulatory factor Rattus norvegicus 94-97 976263-3 1976 The alkylation of a histidine residue which is fast and extensive when the alkylation side chain is on the C-3 carbon atom, is dramatically decreased when alkylating side chain is shifted towards rings B and D. These results allow the location of this histidine in the vicinity of ring A and probably on the beta face of the steroid nucleus. Steroids 325-332 complement C3 Homo sapiens 107-110 183742-4 1976 It is suggested that the pancreatic androgen receptor, which was also present in castrated female rats, may play a role in sex-steroid regulation of pancreatic function. Steroids 127-134 androgen receptor Rattus norvegicus 36-53 4467-5 1976 Comparison by linear regression of paired UA and UV steroid concentrations of delta5P, delta5P-S, DHEA, and DHEA-S revealed a significant correlation (P less than 0.01) for each steroid. Steroids 52-59 sulfotransferase family 2A member 1 Homo sapiens 108-114 4467-5 1976 Comparison by linear regression of paired UA and UV steroid concentrations of delta5P, delta5P-S, DHEA, and DHEA-S revealed a significant correlation (P less than 0.01) for each steroid. Steroids 178-185 sulfotransferase family 2A member 1 Homo sapiens 108-114 1270958-10 1976 During the late follicular phase however, when both the alpha- and LHbeta-like subunits are present in follicular fluid, they may recombine and enhance steroid production by granulosa cells which are undergoing luteinization at this time. Steroids 152-159 luteinizing hormone subunit beta Homo sapiens 67-73 189591-3 1976 Prolactin-mediated augmentation of testosterone"s effects upon these tissues is related primarily to the growth-promoting influences of this steroid. Steroids 141-148 prolactin Mus musculus 0-9 1173970-0 1975 Inhibition of placental 3beta-hydroxy-steroid dehydrogenase by naturally occurring steroids. Steroids 83-91 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 24-59 1173970-4 1975 Inhibitory effects of naturally occurring steroids on SDH activity were determined from the reduction in initial rate of conversion of 3H-dehydroepiandrosterone to non-digitonin precipitable products by 10 000 x g supernatant from homogenates of human term placentae. Steroids 42-50 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 54-57 1173970-11 1975 It is concluded that inhibition of both sulphatase and SDH by endogenous steroids may provide complementary methods of regulating placental oestrogen synthesis in vivo. Steroids 73-81 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 55-58 167000-7 1975 The relative proportions of the spectral responses to these steroids were dependent on the previous extent of adrenal activation by adrenocorticotropic hormone (ACTH), because this stimulatory process altered the combination of mitochondrial cholesterol with cytochrome P-450scc. Steroids 60-68 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 270-278 167000-8 1975 It is proposed that the two steroid binding sites on cytochrome P-450scc interact with steroids in the following way: site I binds cholesterol, 25-hydroxycholesterol, and 20alpha, 22R-dihydroxycholesterol with formation of a partially high spin cytochrome; site II binds both pregnenolone and 20alpha-OH cholesterol resulting in a low spin cytochrome. Steroids 28-35 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 64-72 167000-8 1975 It is proposed that the two steroid binding sites on cytochrome P-450scc interact with steroids in the following way: site I binds cholesterol, 25-hydroxycholesterol, and 20alpha, 22R-dihydroxycholesterol with formation of a partially high spin cytochrome; site II binds both pregnenolone and 20alpha-OH cholesterol resulting in a low spin cytochrome. Steroids 87-95 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 64-72 167001-2 1975 Steroid-induced difference spectra have been used to examine the combination of cholesterol with adrenal mitochondrial cytochrome P-450 which participates in cholesterol side chain cleavage (P-450scc) and the depletion of cholesterol from the cytochrome which results from turnover of the enzyme system. Steroids 0-7 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 191-199 167001-9 1975 Steroid-induced difference spectra indicate that sites I and II on cytochrome P-450scc are similarly depleted after metabolism of mitochondrial cholesterol in vitro and after inhibition of the action of ACTH in vivo. Steroids 0-7 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 78-86 1115999-0 1975 Effect of gonadal steroids on activities of monoamine oxidase and choline acetylase in rat brain. Steroids 18-26 choline O-acetyltransferase Rattus norvegicus 66-83 167554-14 1975 Experimental evidence suggests that rat ADH is a single unique protein which, like horse liver ADH, SS, is active with steroids. Steroids 119-127 aldo-keto reductase family 1 member A1 Homo sapiens 95-98 4515943-0 1973 Rates of induction of specific translatable messenger RNAs for ovalbumin and avidin by steroid hormones. Steroids 87-103 ovalbumin (SERPINB14) Gallus gallus 63-72 4515943-4 1973 Single injections of estrogen in chicks previously withdrawn from all steroid hormones for 2 weeks led to rapid increases in ovalbumin mRNA with 3 hr, which coincided with increases in the rate of ovalbumin synthesis. Steroids 70-86 ovalbumin (SERPINB14) Gallus gallus 125-134 4267203-0 1973 [Inhibition of glucose-6-phosphate dehydrogenase by steroids. Steroids 52-60 glucose-6-phosphate dehydrogenase Homo sapiens 15-48 4144601-0 1972 [Glucose-6-phosphate dehydrogenase inhibition by steroids. Steroids 49-57 glucose-6-phosphate dehydrogenase Homo sapiens 1-34 14288885-0 1965 [INHIBITION BY WATER-SOLUBLE STEROIDS OF THE UTERINE ACTION OF OXYTOCIN]. Steroids 29-37 oxytocin/neurophysin I prepropeptide Homo sapiens 63-71 14238850-0 1964 [INHIBITION OF TRYPTOPHAN OXYGENASE ACTIVITY BY THE SULFATE ESTER OF STEROID HORMONES]. Steroids 69-85 tryptophan 2,3-dioxygenase Homo sapiens 15-35 16590626-0 1960 INHIBITION OF MAMMALIAN GLUCOSE-6-PHOSPHATE DEHYDROGENASE BY STEROIDS. Steroids 61-69 glucose-6-phosphate dehydrogenase Homo sapiens 24-57 14430896-0 1959 [Influence of STH extracted from pituitary on the urinary reducing steroid quotient of human subjects]. Steroids 67-74 saitohin Homo sapiens 14-17 13481249-5 1957 Maximal activity in negation of interference is associated with the presence of oxygen at the C-11 position of the steroid molecule. Steroids 115-122 RNA polymerase III subunit K Homo sapiens 94-98 13275971-0 1955 On the mechanism of the c-11beta-hydroxylation of steroids; a study with H2O18 and O218. Steroids 50-58 endogenous retrovirus group K member 20 Homo sapiens 24-32 13027328-0 1952 Prevention of growth hormone-induced diabetes in hypophysectomized dogs by adrenocortical steroids. Steroids 90-98 somatotropin Canis lupus familiaris 14-28 15404837-0 1950 The bio-oxygenation of steroids at C-11. Steroids 23-31 RNA polymerase III subunit K Homo sapiens 35-39 20276262-0 1946 Effects of castration and treatment with sex steroids on the synthesis of serum cholinesterase in the rat. Steroids 45-53 butyrylcholinesterase Rattus norvegicus 80-94 21018771-0 1946 The introduction of oxygen into the steroid nucleus at the C11 position. Steroids 36-43 RNA polymerase III subunit K Homo sapiens 59-62 33953236-2 2021 The mode of action of GCs for stress coping is mediated largely by the steroid binding to the glucocorticoid receptor (GR), a ligand-bound transcription factor, and modulating the expression of target genes. Steroids 71-78 glucocorticoid receptor Oncorhynchus mykiss 94-117 33953236-2 2021 The mode of action of GCs for stress coping is mediated largely by the steroid binding to the glucocorticoid receptor (GR), a ligand-bound transcription factor, and modulating the expression of target genes. Steroids 71-78 glucocorticoid receptor Oncorhynchus mykiss 119-121 33609452-1 2021 Developmental transitions, such as puberty or metamorphosis, are tightly controlled by steroid hormones and can be delayed by the appearance of growth abnormalities, developmental tumors, or inflammatory disorders such as inflammatory bowel disease or cystic fibrosis.1-4 Here, we used a highly inflammatory epithelial model of malignant transformation in Drosophila5,6 to unravel the role of Upd3-a cytokine with homology to interleukin-6-and the JAK/STAT signaling pathway in coupling inflammation to a delay in metamorphosis. Steroids 87-94 unpaired 3 Drosophila melanogaster 393-397 33609452-2 2021 We present evidence that Upd3 produced by malignant and nearby cell populations signals to the prothoracic gland-an endocrine tissue primarily dedicated to the production of the steroid hormone ecdysone-to activate JAK/STAT and bantam microRNA (miRNA) and to delay metamorphosis. Steroids 178-185 unpaired 3 Drosophila melanogaster 25-29 33898477-12 2021 Conclusions and Relevance: Our systemic review and meta-analysis suggests that CPT could be an effective therapeutic option with promising evidence on the safety and reduced mortality in concomitant treatment for COVID-19 along with antiviral/antimicrobial drugs, steroids, and other supportive care. Steroids 264-272 choline phosphotransferase 1 Homo sapiens 79-82 33258555-7 2021 In summary, our research has demonstrated that environment-relevant level of BPA exposure leads to steroid hormone synthesis disorder in human ovarian granulosa cells, which might cause the reduction of gene expression in hormone synthesis and the suppression of the FSHR/GS/AC signaling pathway. Steroids 99-106 follicle stimulating hormone receptor Homo sapiens 267-271 33729619-3 2021 The present study investigated the effect of nutritional protein restriction during puberty on the oestrous cycle and expression of sex steroid receptors (AR, ERalpha e ERbeta) in ovarian and uterine tissues of adult rats. Steroids 136-143 androgen receptor Rattus norvegicus 155-157 33739385-5 2022 Sex steroids such as androgens, progestins, and estrogen and their receptors (ERalpha, ERbeta, GPER; PR-A, PR-B; AR) have been identified as important modifiers of angiogenesis, and sex differences have been reported for anti-angiogenic drugs. Steroids 4-12 G protein-coupled estrogen receptor 1 Homo sapiens 95-99 33492760-12 2021 Baseline NfL was associated with number of intravenous steroid infusions (mean = 0.2; SD = 3.0, P = 0.013), whereas the average of baseline and 12 months NfL values related to inpatient stays at 12 months (mean = 0.2; SD = 3.0 P = 0.053). Steroids 55-62 neurofilament light chain Homo sapiens 9-12 33002425-1 2021 BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family. Steroids 27-34 vitamin D receptor Homo sapiens 91-109 33002425-1 2021 BACKGROUND: Vitamin D is a steroid hormone that exerts its actions through ligation of the vitamin D receptor (VDR), a transcription factor of the nuclear receptor family. Steroids 27-34 vitamin D receptor Homo sapiens 111-114 33098938-11 2021 CONCLUSION: In ovariectomized rats treated with tibolone, Hprt and Ppia genes showed high stability as housekeeping genes for qPCR analysis Suggested Reviewers: Andrea Crespo Castrillo PhD Research,Neuroactive Steroids, Instituto Cajal andrea.crespo@cajal.csic.es Expert in efects of tibolone in brain. Steroids 210-218 hypoxanthine phosphoribosyltransferase 1 Rattus norvegicus 58-62 33581723-13 2021 The expressions of Akr1c18, Mamld1, and Cyp19a1, which are involved in the synthesis of steroid hormones, were reduced in the ovaries of mutant mice. Steroids 88-95 mastermind-like domain containing 1 Mus musculus 28-34 33549124-14 2021 Considering the putative role of RORA as a nuclear steroid hormone receptor, we conducted a subgroup analysis by gender. Steroids 51-58 RAR related orphan receptor A Homo sapiens 33-37 33360489-3 2021 Steroidogenic factor-1 (SF-1, NR5a1) is a nuclear receptor essential for the fetal development of steroid hormones producing organs and SF-1 knockout mice (Sf-1 KO) are therefore born without gonads and adrenal glands. Steroids 98-105 nuclear receptor subfamily 5, group A, member 1 Mus musculus 30-35 33373934-12 2021 Our in-vitro finding support that IGF1 plays a critical role in placental development by promoting angiogenesis, steroid synthesis, and cell proliferation during early pregnancy. Steroids 113-120 insulin-like growth factor I Bubalus bubalis 34-38 29299119-8 2017 Finally, we showed that PK11195, a pharmacological inhibitor of the cholesterol translocator TSPO, embedded in Mitochondria-Associated Membranes, exerts a synergetic effect with mitotane in inducing Mitochondria-Associated Membranes disruption, apoptosis and in inhibiting steroid secretion. Steroids 273-280 translocator protein Homo sapiens 93-97 28532828-7 2017 Apelin was found to increase basal steroid secretion, but decrease IGF1- and FSH-induced steroid secretion, and 3betaHSD and CYP19 expression. Steroids 35-42 APLN Sus scrofa 0-6 28532828-7 2017 Apelin was found to increase basal steroid secretion, but decrease IGF1- and FSH-induced steroid secretion, and 3betaHSD and CYP19 expression. Steroids 89-96 APLN Sus scrofa 0-6 28655875-1 2017 The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is involved in the synthesis of active steroid hormones. Steroids 107-123 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-55 28655875-1 2017 The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is involved in the synthesis of active steroid hormones. Steroids 107-123 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 57-66 28235666-2 2017 Cancer cells derive most of their energy from oxidative phosphorylation unlike normal ones during cell progression TSPO protein present in external mitochondrial membrane, is involved in various cellular functions like Cell proliferation, mitochondrial respiration, synthesis of steroids and also participates in import of cholesterol into the inner mitochondrial membrane from outside of the membrane of mitochondria. Steroids 279-287 translocator protein Homo sapiens 115-119 28325716-9 2017 The stimulators were found to share the basic backbone structure of the physiologic steroids, which suggests a potential in vivo relevance of in vitro stimulation of MRP2 transport. Steroids 84-92 ATP binding cassette subfamily C member 2 Homo sapiens 166-170 28319688-1 2017 BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. Steroids 216-224 sulfotransferase family 2A member 1 Homo sapiens 139-145 28263860-1 2017 Despite continued interest in the 18kDa translocator protein (PBR/TSPO) as a biomarker and a therapeutic target for a range of diseases, its functional role, such as in the steroid synthesis pathway and energy metabolism has either become contentious or remains to be described more precisely. Steroids 173-180 translocator protein Homo sapiens 62-65 28263860-1 2017 Despite continued interest in the 18kDa translocator protein (PBR/TSPO) as a biomarker and a therapeutic target for a range of diseases, its functional role, such as in the steroid synthesis pathway and energy metabolism has either become contentious or remains to be described more precisely. Steroids 173-180 translocator protein Homo sapiens 66-70 28565776-2 2017 In the present study, an in vitro model of a vitamin D receptor response element (VDRE) reporter gene assay in mesenchymal stem cells (MSCs) was used to identify steroids that enhanced osteogenic differentiation of MSCs. Steroids 162-170 vitamin D receptor Homo sapiens 45-63 28190867-2 2017 These reactions comprise a hydroxylation at position C11 of the steroid intermediate deoxycorticosterone yielding corticosterone, followed by a hydroxylation at position C18 yielding 18-hydroxy-corticosterone and a subsequent oxidation of the hydroxyl group at C18, which results in the formation of aldosterone. Steroids 64-71 aldo-keto reductase family 1 member C4 Homo sapiens 53-56 28494548-12 2017 Meanwhile, 19 CYP450 subtypes, accounting for 5% of the differentially expressed genes, were identified, and CYP2E1, CYP2C70, CYP3A11, CYP3A25, CYP2D26, CYP4A10, CYP17A1, CYP2B10, and CYP2C38 were involved in oxidative stress, steroid hormone metabolism, fatty acid metabolism, arachidonic acid metabolism, and the PPAR signaling pathway. Steroids 227-242 cytochrome P450, family 2, subfamily c, polypeptide 70 Mus musculus 117-124 28494548-12 2017 Meanwhile, 19 CYP450 subtypes, accounting for 5% of the differentially expressed genes, were identified, and CYP2E1, CYP2C70, CYP3A11, CYP3A25, CYP2D26, CYP4A10, CYP17A1, CYP2B10, and CYP2C38 were involved in oxidative stress, steroid hormone metabolism, fatty acid metabolism, arachidonic acid metabolism, and the PPAR signaling pathway. Steroids 227-242 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 126-133 28417080-14 2017 A similar biochemical process is found in steroid synthesis with cholesterol uptake being the initial energy-dependent step and later the heme protein ferredoxin 1 which is required for steroid synthesis. Steroids 42-49 ferredoxin 1 Homo sapiens 151-163 28417080-14 2017 A similar biochemical process is found in steroid synthesis with cholesterol uptake being the initial energy-dependent step and later the heme protein ferredoxin 1 which is required for steroid synthesis. Steroids 186-193 ferredoxin 1 Homo sapiens 151-163 28325259-1 2017 The vitamin D receptor (VDR) is a member of the thyroid-steroid family of nuclear transcription factors. Steroids 56-63 vitamin D receptor Homo sapiens 4-22 28325259-1 2017 The vitamin D receptor (VDR) is a member of the thyroid-steroid family of nuclear transcription factors. Steroids 56-63 vitamin D receptor Homo sapiens 24-27 27346668-4 2017 From the 18 supplements, 19 steroids were identified and for each, its intrinsic androgenic potency was determined by a yeast cell (Saccharomyces cerevisiae) androgen bioassay and its potential androgenic potency was determined by a liver (HuH7) cell androgen bioassay. Steroids 28-36 MIR7-3 host gene Homo sapiens 240-244 28324006-7 2017 Results showed (1) steroid-dependent and steroid-independent seasonal changes in kisspeptin and NKB, but not dynorphin, immunoreactivity; (2) increased D2R coexpression during ANS that was dependent on the presence of E2; and (3) evidence that KNDy cells receive direct contact from dopaminergic terminals and that this input increases during ANS. Steroids 19-26 tachykinin-3 Ovis aries 96-99 28228528-1 2017 Congenital adrenal hyperplasia (CAH), resulting from mutations in CYP11B1, a gene encoding 11beta-hydroxylase, represents a rare autosomal recessive Mendelian disorder of aberrant sex steroid production. Steroids 184-191 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 66-73 28240737-1 2017 Fatty acid synthase (FASN), the key enzyme for endogenous synthesis of fatty acids, is overexpressed and hyperactivated in a biologically aggressive subset of sex steroid-related tumors, including breast carcinomas. Steroids 163-170 fatty acid synthase Homo sapiens 0-19 28240737-1 2017 Fatty acid synthase (FASN), the key enzyme for endogenous synthesis of fatty acids, is overexpressed and hyperactivated in a biologically aggressive subset of sex steroid-related tumors, including breast carcinomas. Steroids 163-170 fatty acid synthase Homo sapiens 21-25 28352346-0 2017 Salvianolic acid B prevents steroid-induced osteonecrosis of the femoral head via PPARgamma expression in rats. Steroids 28-35 peroxisome proliferator-activated receptor gamma Rattus norvegicus 82-91 28050764-1 2017 Cutaneous melanoma (CM) cells are resistant to apoptosis, and steroid hormones are involved in this process through regulation of TP53, MDM2, BAX, and BCL2 expression. Steroids 62-78 MDM2 proto-oncogene Homo sapiens 136-140 28100228-9 2017 A significant negative correlation between SCF expression and inhaled steroid while significant positive correlation with serum IgE was found. Steroids 70-77 KIT ligand Homo sapiens 43-46 27928953-1 2017 Novel steroid derivatives of 5Z,9Z-dienoic acids were prepared by the DCC/DMAP-catalyzed esterification of (5Z,9Z)-tetradeca-5,9-dienoic acid with hydroxy steroids. Steroids 6-13 DCC netrin 1 receptor Homo sapiens 70-73 27801710-5 2017 The review highlights recent observations, such as GCS-induced dysregulation of key transcription factors involved in host defence, role of airway infections altering expression of critical regulatory elements like the noncoding microRNAs, and the importance of interleukin (IL)-10 in reinstating steroid response in key immune cells. Steroids 297-304 interleukin 10 Homo sapiens 262-281 27997540-8 2016 Our analysis revealed that mutations in JAK1 and KRAS, two genes encoding components of the interleukin 7 receptor (IL7R) signaling pathway, were associated with steroid resistance and poor outcome. Steroids 162-169 KRAS proto-oncogene, GTPase Homo sapiens 49-53 27997540-13 2016 We found that expressing mutant IL7R, JAK1, or NRAS, or wild-type NRAS or AKT, specifically induced steroid resistance without affecting sensitivity to vincristine or L-asparaginase. Steroids 100-107 NRAS proto-oncogene, GTPase Homo sapiens 47-51 27997540-13 2016 We found that expressing mutant IL7R, JAK1, or NRAS, or wild-type NRAS or AKT, specifically induced steroid resistance without affecting sensitivity to vincristine or L-asparaginase. Steroids 100-107 NRAS proto-oncogene, GTPase Homo sapiens 66-70 27746313-9 2016 Additionally, expression analysis of genes involved in steroidogenesis and the steroids metabolism revealed significant down-regulation of Star, Cyp11a1, Hsd3b1, Hsd17b3 and Srd5a1 mRNAs in AgNPs/AgSPs-exposed animals. Steroids 79-87 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 145-152 27910957-0 2016 miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARgamma and GREM1. Steroids 61-68 peroxisome proliferator-activated receptor gamma Rattus norvegicus 100-109 27910957-0 2016 miR-27a attenuates adipogenesis and promotes osteogenesis in steroid-induced rat BMSCs by targeting PPARgamma and GREM1. Steroids 61-68 gremlin 1, DAN family BMP antagonist Rattus norvegicus 114-119 27086733-12 2016 In combination with a steroid, the compounded L-asparaginase evaluated in this study is safe and demonstrates activity against canine lymphoma. Steroids 22-29 asparaginase and isoaspartyl peptidase 1 Canis lupus familiaris 46-60 27654711-3 2016 This is best typified by the three members of the steroid receptor coactivator (SRC) family, each of which integrates steroid hormone signaling and growth factor pathways to drive oncogenic gene expression programs in breast, endometrial, ovarian, prostate, and other cancers. Steroids 118-133 steroid receptor RNA activator 1 Homo sapiens 50-78 27654711-3 2016 This is best typified by the three members of the steroid receptor coactivator (SRC) family, each of which integrates steroid hormone signaling and growth factor pathways to drive oncogenic gene expression programs in breast, endometrial, ovarian, prostate, and other cancers. Steroids 118-133 steroid receptor RNA activator 1 Homo sapiens 80-83 27387444-0 2016 Regulation of sex steroid production and mRNAs encoding gonadotropin receptors and steroidogenic proteins by gonadotropins, cyclic AMP and insulin-like growth factor-I in ovarian follicles of rainbow trout (Oncorhynchus mykiss) at two stages of vitellogenesis. Steroids 18-25 insulin-like growth factor I Oncorhynchus mykiss 139-167 32873964-5 2021 These include protein-altering variants in steroid hormone production genes (POR, UGT2B7). Steroids 43-50 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 82-88 33220437-6 2021 What"s more, venlafaxine (1 mug/L) upregulated the expression of steroid regulatory factors including steroidogenic acute regulatory protein (star), cytochrome P450 family member 11A1 (cyp11a1) and 11 beta hydroxylase (cyp11b1) by cAMP-pCREB pathway, affecting the function of the steroidogenic cells, which might be involved in the increased cortisol levels in zebrafish larvae. Steroids 65-72 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 185-192 15695463-2 2005 Regulation of seed storage protein genes At2S3 and CRC by ABI3 and FUS3 was investigated using transgenic plants in which ABI3 and FUS3 could be ectopically induced by steroid hormones. Steroids 168-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 122-126 32638280-3 2021 Therefore, we correlated seminal IL-18 with IL-1beta and both cytokines with the seminal steroids, whose increase indicates the activation of neuroendocrine stress response systems. Steroids 89-97 interleukin 18 Homo sapiens 33-38 15673671-10 2005 Together, the present findings indicate that SRC-1 modulates steroid-dependent gene transcription and behavior and highlight the rapid time course of steroid-induced brain plasticity in adult quail. Steroids 61-68 nuclear receptor coactivator 1 Mus musculus 45-50 33370992-1 2020 We present a case of a 49-year-old woman diagnosed with aquaporin-4 antibody-positive transverse myelitis, who developed a significant transaminitis 2 months after commencing mycophenolate mofetil (MMF) as a steroid-sparing agent. Steroids 208-215 aquaporin 4 Homo sapiens 56-67 15634767-8 2005 In addition, aging involves deterioration in this VIP-driven rhythmicity, which impacts the ability of steroids to induce GnRH neuronal activation. Steroids 103-111 gonadotropin releasing hormone 1 Rattus norvegicus 122-126 33089319-0 2020 Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion. Steroids 66-73 KiSS-1 metastasis-suppressor Mus musculus 0-10 15637526-8 2005 In addition to its role in pharmacokinetics, CYP2C9 contributes to the metabolism of fatty acids, prostanoids, and steroid hormones, and it may catalyze potentially toxic bioactivation reactions. Steroids 115-131 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 45-51 33259013-1 2020 Vitamin D Receptor (VDR), a nuclear steroid receptor, is a transcription factor with a primary physiologic role in calcium metabolism. Steroids 36-43 vitamin D receptor Homo sapiens 0-18 33259013-1 2020 Vitamin D Receptor (VDR), a nuclear steroid receptor, is a transcription factor with a primary physiologic role in calcium metabolism. Steroids 36-43 vitamin D receptor Homo sapiens 20-23 15589698-1 2005 Interactions among gonadal steroid hormones and the dopamine synthesizing enzymes, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC), participate in hypothalamic functions. Steroids 27-34 tyrosine 3-monooxygenase Cavia porcellus 83-103 33243235-2 2020 CASE PRESENTATION: A 19-year-old woman college student was admitted to our hospital owing to uncontrolled severe asthma despite using the maximum dose of steroid inhalation. Steroids 154-161 immunoglobulin kappa variable 2-28 Homo sapiens 19-23 15589698-1 2005 Interactions among gonadal steroid hormones and the dopamine synthesizing enzymes, tyrosine hydroxylase (TH) or aromatic L-amino acid decarboxylase (AADC), participate in hypothalamic functions. Steroids 27-34 tyrosine 3-monooxygenase Cavia porcellus 105-107 14624357-5 2005 We investigated whether steroids could affect the antimicrobial effect of IFN-gamma-induced IDO activation. Steroids 24-32 indoleamine 2,3-dioxygenase 1 Homo sapiens 92-95 33158280-1 2020 The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Steroids 121-128 progesterone receptor Mus musculus 14-35 15475569-9 2005 Lead compounds, 4-chloro-N-phenylanthranilic acid and 4-benzoyl-benzoic acid for the N-phenylanthranilic acid analogs and most steroid carboxylates, exhibited IC(50) values that had greater than 500-fold selectivity for AKR1C isozymes compared with COX-1 and COX-2. Steroids 127-134 mitochondrially encoded cytochrome c oxidase I Homo sapiens 249-254 32820859-14 2020 Anti-hypertensive use 1-year post-transplant was not associated with those factors, but rather with age at transplant and steroid use. Steroids 122-129 unconventional SNARE in the ER 1 Homo sapiens 18-23 15664414-1 2005 This study was to investigate the expression of Cdk inhibitors p27kip1 and p57kip2 during the development of mouse placenta and during the steroid-treated culture of human choriocarcinoma JEG-3 cells. Steroids 139-146 cyclin-dependent kinase inhibitor 1C (P57) Mus musculus 75-82 33287925-0 2020 Relationship between TIM-3 gene polymorphisms and steroid-resistant primary nephrotic syndrome in children. Steroids 50-57 hepatitis A virus cellular receptor 2 Homo sapiens 21-26 33287925-2 2020 This experiment was carried out to investigate the association of three single nucleotide polymorphisms (SNPs) of T-cell immunoglobulin and mucin-domain-containing-3 (Tim-3) with childhood primary nephrotic syndrome (PNS) steroid response in Han Chinese. Steroids 222-229 hepatitis A virus cellular receptor 2 Homo sapiens 114-165 33287925-2 2020 This experiment was carried out to investigate the association of three single nucleotide polymorphisms (SNPs) of T-cell immunoglobulin and mucin-domain-containing-3 (Tim-3) with childhood primary nephrotic syndrome (PNS) steroid response in Han Chinese. Steroids 222-229 hepatitis A virus cellular receptor 2 Homo sapiens 167-172 33287925-11 2020 It concluded that this study provided evidence showing that the polymorphisms of Rs1051746 and Rs10053538 at the TIM-3 gene were related to childhood PNS steroid response. Steroids 154-161 hepatitis A virus cellular receptor 2 Homo sapiens 113-118 15623622-2 2004 The high frequency of NPY receptors in steroid hormone-producing ovarian sex cord-stromal tumors, together with the known influence of NPY on steroid hormone and catecholamine secretion in the rodent adrenal gland, led to the investigation of NPY receptor expression in the human adrenal gland and related tumors. Steroids 39-54 neuropeptide Y Homo sapiens 22-25 15623634-6 2004 We also investigated the regulation of AP-2gamma by steroids and retinoic acid. Steroids 52-60 transcription factor AP-2 gamma Homo sapiens 39-48 15649862-9 2004 CONCLUSIONS: In contrast to CF-patients in the exhaled air of steroid-naive asthmatics elevated eCO concentrations are found that may serve as non-invasive inflammatory marker. Steroids 62-69 ciliogenesis associated kinase 1 Homo sapiens 96-99 33143176-2 2020 The NSDHL gene codes for the NAD(P)-dependent steroid dehydrogenase-like protein, which is involved in cholesterol biosynthesis. Steroids 46-53 NAD(P) dependent steroid dehydrogenase-like Homo sapiens 4-9 32745909-11 2020 Furthermore, several proteins involved in the biosynthesis and metabolism of steroid hormone pathways were significantly up/downregulated by SNS, including CYP2B19, CYP7B1 (validated by qRT-PCR) and HSD3b5 (validated by qRT-PCR and western blotting). Steroids 77-84 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 165-171 15531544-8 2004 In conclusion, our results suggest that there are direct effects of E(2) and P(4) on HEEC and provide a new understanding of the physiological role of sex steroids in the regulation of endometrial events such as angiogenesis. Steroids 155-163 solute carrier family 10 member 4 Homo sapiens 77-81 33071817-3 2020 We earlier proved that lipid raft disintegration by cholesterol depletion using a novel carboxamido-steroid compound (C1) and methyl beta-cyclodextrin (MCD) significantly and concentration-dependently inhibit TRPV1 and TRPA1 activation in primary sensory neurons and receptor-expressing cell lines. Steroids 100-107 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 219-224 33013632-11 2020 Once clinicians suspect acute ON with serum AQP4-IgG, swift administration of steroid pulse therapy before confirming the positivity of serum AQP4-IgG would be beneficial for preserving visual function. Steroids 78-85 aquaporin 4 Homo sapiens 44-48 15458395-5 2004 Leptin and lipoprotein lipase are two key proteins in adipose tissues that are regulated by transcriptional control with sex steroid hormones. Steroids 125-141 leptin Homo sapiens 0-29 31922608-10 2020 CONCLUSION: IL33 contributes to DEP mediated increase in allergen-induced Th2 inflammation and AHR in a mouse model of severe steroid resistant asthma, potentially through the accumulation of pathogenic IL5+ IL17A+ CD4+ effector T-cells. Steroids 126-133 interleukin 33 Mus musculus 12-16 15525570-0 2004 Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. Steroids 0-7 interleukin 1 alpha Homo sapiens 78-96 32395877-3 2020 Data from hepatocytes derived from Hnf1a knock-out mice demonstrated dysregulation of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which regulates glucocorticoid availability and action in target tissues, together with 11beta-HSD2 and steroid A-ring reductases, 5alpha- and 5beta-reductase. Steroids 100-107 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 130-141 15456875-3 2004 It has been suggested, therefore, that steroid-induced MYOC protein levels cause steroid-induced glaucoma and that protein level-increasing mutations in MYOC contribute to glaucoma not associated with steroid use. Steroids 39-46 myocilin Mus musculus 55-59 32675276-5 2020 Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size. Steroids 246-253 Neuropeptide F receptor Drosophila melanogaster 26-49 32675276-5 2020 Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size. Steroids 246-253 Neuropeptide F receptor Drosophila melanogaster 51-55 32675276-5 2020 Here, we demonstrate that Neuropeptide F Receptor (NPFR), best studied as a conserved regulator of feeding behavior from insects to mammals, also regulates development in Drosophila Knocking down NPFR in the prothoracic gland, which produces the steroid hormone ecdysone, generates developmental delay and an extended feeding period, resulting in increased body size. Steroids 246-253 Neuropeptide F receptor Drosophila melanogaster 196-200 15456875-3 2004 It has been suggested, therefore, that steroid-induced MYOC protein levels cause steroid-induced glaucoma and that protein level-increasing mutations in MYOC contribute to glaucoma not associated with steroid use. Steroids 81-88 myocilin Mus musculus 55-59 15456875-3 2004 It has been suggested, therefore, that steroid-induced MYOC protein levels cause steroid-induced glaucoma and that protein level-increasing mutations in MYOC contribute to glaucoma not associated with steroid use. Steroids 81-88 myocilin Mus musculus 55-59 15288809-4 2004 Similarly, 17betaHSD2 yields a >95:5 ratio of oxidized:reduced steroids for both androgens and estrogens. Steroids 66-74 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 11-21 32593151-0 2020 Analysis of 52 C19 and C21 steroids by UPC2-MS/MS: Characterising the C11-oxy steroid metabolome in serum. Steroids 27-35 aldo-keto reductase family 1 member C4 Homo sapiens 70-73 32593151-0 2020 Analysis of 52 C19 and C21 steroids by UPC2-MS/MS: Characterising the C11-oxy steroid metabolome in serum. Steroids 27-34 aldo-keto reductase family 1 member C4 Homo sapiens 70-73 32593151-2 2020 While the C11-oxy C19 steroids have been firmly established in the steroid arena, the C11-oxy C21 steroids are now also of significance. Steroids 98-106 aldo-keto reductase family 1 member C4 Homo sapiens 86-89 32593151-3 2020 The current study reports on a high-throughput ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) method for the separation and quantification of 52 steroids in peripheral serum, which include the C11-oxy C19 and C11-oxy C21 steroids. Steroids 181-189 aldo-keto reductase family 1 member C4 Homo sapiens 229-232 15274648-5 2004 In human endometrial LIF expression depends on cellular localizations, steroid hormones, menstrual stages and a local cytokine network. Steroids 71-87 LIF interleukin 6 family cytokine Homo sapiens 21-24 32593151-3 2020 The current study reports on a high-throughput ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) method for the separation and quantification of 52 steroids in peripheral serum, which include the C11-oxy C19 and C11-oxy C21 steroids. Steroids 181-189 aldo-keto reductase family 1 member C4 Homo sapiens 245-248 32593151-3 2020 The current study reports on a high-throughput ultra-performance convergence chromatography tandem mass spectrometry (UPC2-MS/MS) method for the separation and quantification of 52 steroids in peripheral serum, which include the C11-oxy C19 and C11-oxy C21 steroids. Steroids 257-265 aldo-keto reductase family 1 member C4 Homo sapiens 229-232 32593151-13 2020 C11-oxy steroid metabolites produced as intermediates in steroidogenic pathways, together with end-products included in the method can potentially characterise the 11beta-hydroxyandrostenedione-, C21- and C11-oxy backdoor pathways in vivo. Steroids 8-15 aldo-keto reductase family 1 member C4 Homo sapiens 0-3 32593151-13 2020 C11-oxy steroid metabolites produced as intermediates in steroidogenic pathways, together with end-products included in the method can potentially characterise the 11beta-hydroxyandrostenedione-, C21- and C11-oxy backdoor pathways in vivo. Steroids 8-15 aldo-keto reductase family 1 member C4 Homo sapiens 205-208 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 estrogen receptor 1 (alpha) Mus musculus 39-46 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 estrogen receptor 1 (alpha) Mus musculus 242-249 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 olfactory receptor family 10 subfamily A member 2 Mus musculus 281-290 15249132-0 2004 Steroid hormonal regulation of growth, prostate specific antigen secretion, and transcription mediated by the mutated androgen receptor in CWR22Rv1 human prostate carcinoma cells. Steroids 0-7 kallikrein related peptidase 3 Homo sapiens 39-64 32990741-12 2020 Plasma steroid profiles varied according to disease subtype and were particularly distinctive in patients with adenomas due to KCNJ5 variants, who showed better rates of biochemical cure after adrenalectomy than other patients. Steroids 7-14 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 127-132 32990741-17 2020 Conclusions and Relevance: Machine learning-designed combinatorial plasma steroid profiles may facilitate both screening for primary aldosteronism and identification of patients with unilateral adenomas due to pathogenic KCNJ5 variants, who are most likely to show benefit from surgical intervention. Steroids 74-81 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 221-226 15249132-3 2004 Incubation of 22Rv1 cells with various concentrations of testosterone resulted in a dose-dependent 50-80% increase in growth over 72 h. PSA release and transactivation of PRE2-tk-LUC in 22Rv1 cells were stimulated by low concentrations of natural and synthetic androgens (EC(50)s = 10(-10) to 10(-9)M) and a broad range of other classes of steroid hormones, albeit with lower potency. Steroids 340-347 kallikrein related peptidase 3 Homo sapiens 136-139 14982968-0 2004 Characterization of the neutralizing activity of digoxin-specific Fab toward ouabain-like steroids. Steroids 90-98 FA complementation group B Homo sapiens 66-69 33229759-0 2020 Association of Urinary Vitamin D Binding Protein and Neutrophil Gelatinase-Associated Lipocalin with Steroid Responsiveness in Idiopathic Nephrotic Syndrome of Childhood. Steroids 101-108 GC vitamin D binding protein Homo sapiens 23-48 33229759-0 2020 Association of Urinary Vitamin D Binding Protein and Neutrophil Gelatinase-Associated Lipocalin with Steroid Responsiveness in Idiopathic Nephrotic Syndrome of Childhood. Steroids 101-108 lipocalin 2 Homo sapiens 53-95 33229759-2 2020 In this study, we assessed urine Vitamin-D binding protein (VDBP) and neutrophil gelatinase-associated lipocalin (NGAL) levels as a predictor of steroid responsiveness in idiopathic NS. Steroids 145-152 GC vitamin D binding protein Homo sapiens 33-58 33229759-2 2020 In this study, we assessed urine Vitamin-D binding protein (VDBP) and neutrophil gelatinase-associated lipocalin (NGAL) levels as a predictor of steroid responsiveness in idiopathic NS. Steroids 145-152 lipocalin 2 Homo sapiens 70-112 33229759-2 2020 In this study, we assessed urine Vitamin-D binding protein (VDBP) and neutrophil gelatinase-associated lipocalin (NGAL) levels as a predictor of steroid responsiveness in idiopathic NS. Steroids 145-152 lipocalin 2 Homo sapiens 114-118 14988430-3 2004 Considered a xenobiotic sensing receptor, CAR transcriptionally modifies the expression of genes involved in the metabolism and elimination of xenobiotics and steroids in response to these compounds and other cellular metabolites. Steroids 159-167 CXADR pseudogene 1 Homo sapiens 42-45 33229759-10 2020 Urine levels of VDBP and NGAL can predict steroid responsiveness in patients with idiopathic NS. Steroids 42-49 GC vitamin D binding protein Homo sapiens 16-20 33229759-10 2020 Urine levels of VDBP and NGAL can predict steroid responsiveness in patients with idiopathic NS. Steroids 42-49 lipocalin 2 Homo sapiens 25-29 15290871-0 2004 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Steroids 50-66 PGP Canis lupus familiaris 0-14 32806646-11 2020 Our results suggest that steroids inhibit CSE-regulated MMP-2 and TIMP-2 production and activation through the ROS/ PI3K, Akt, and NF-kappaB signaling pathways in nasal fibroblasts. Steroids 25-33 TIMP metallopeptidase inhibitor 2 Homo sapiens 66-72 15290871-0 2004 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Steroids 50-66 PGP Canis lupus familiaris 16-20 32773037-0 2020 Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARgamma-homolog Eip75B in Drosophila. Steroids 9-16 Ecdysone-induced protein 75B Drosophila melanogaster 103-109 15290871-1 2004 PURPOSE: To determine whether female sex-steroid hormones and their metabolites can modulate P-glycoprotein (P-gp) expression and catalytic activity and to investigate P-gp mediated transport of these sex-steroids across MDR1-transfected Madine-Darby canine kidney (MDCK) cells. Steroids 41-48 PGP Canis lupus familiaris 93-107 32749219-2 2020 Here we unveil a novel role of Rspo1 in promoting estrogen receptor alpha (Esr1) expression, hence regulating the output of steroid hormone signaling in the mouse mammary gland. Steroids 124-131 R-spondin 1 Mus musculus 31-36 15290871-1 2004 PURPOSE: To determine whether female sex-steroid hormones and their metabolites can modulate P-glycoprotein (P-gp) expression and catalytic activity and to investigate P-gp mediated transport of these sex-steroids across MDR1-transfected Madine-Darby canine kidney (MDCK) cells. Steroids 41-48 PGP Canis lupus familiaris 109-113 15157792-2 2004 Previous studies confirmed that endogenous sex steroids may influence serum resistin concentration in women. Steroids 47-55 resistin Homo sapiens 76-84 32533406-9 2020 In addition, THRalpha expression correlates with gonadotropin receptors, steroid hormone receptors, TA-MUC1 and glycodelin. Steroids 73-80 thyroid hormone receptor alpha Homo sapiens 13-21 32641829-4 2020 The active ovaries of the fly produce the steroid hormone ecdysone, which stimulates the division and expansion of intestinal stem cells in two distinct proliferative phases via the steroid receptors EcR and Usp and their downstream targets Broad, Eip75B and Hr3. Steroids 42-49 Ecdysone-induced protein 75B Drosophila melanogaster 248-254 15153534-0 2004 CD56+ cells induce steroid resistance in B cells exposed to IL-15. Steroids 19-26 neural cell adhesion molecule 1 Homo sapiens 0-4 15288181-3 2004 Endometrial and placental CRH are under the endocrine control of gonadal steroids as well as under autocrine/paracrine regulation by prostanoids and interleukins. Steroids 73-81 corticotropin releasing hormone Homo sapiens 26-29 15169901-4 2004 The synthesis of DHEA and sex steroids, but not mouse glucocorticoids and mineralocorticoids, requires P450c17, which catalyzes both 17 alpha-hydroxylase and 17,20-lyase activities. Steroids 30-38 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 103-110 32708046-6 2020 In this review, we aim to provide insight into the diverse ways in which LOX participates in signaling events, and explore the mechanistic details and functional significance of the regulatory and cross-regulatory interactions of LOX with the EGFR, PDGF, VEGF, TGF-beta, mechano-transduction, inflammatory and steroid signaling pathways. Steroids 310-317 lysyl oxidase Homo sapiens 230-233 15169901-13 2004 These data suggest that steroid products of P450c17 have heretofore-unknown essential functions in early embryonic mouse development. Steroids 24-31 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 44-51 15123837-3 2004 We now report the complete sequence of the cloned chicken cDNA for the 1,25D(3)-MARRS (membrane-associated, rapid-response steroid-binding) protein and reveal it to be identical to the multifunctional protein ERp57. Steroids 123-130 protein disulfide isomerase family A member 3 Gallus gallus 209-214 32369415-7 2020 On the basis of the reviewed findings, it is suggested that the SCARB1 gene should be included in the standard glucocorticoid deficiency genetic screening panel to 1) facilitate knowledge development on the relative contribution of SR-BI-mediated cholesterol acquisition to steroid hormone synthesis in humans and 2) open up the possibility to reclassify glucocorticoid deficiency patients without a currently known genetic cause for concomitant treatment optimization. Steroids 274-281 scavenger receptor class B member 1 Homo sapiens 64-70 15096602-6 2004 GnRH neurons receive a major input from gamma-aminobutyric acid (GABA)ergic neurons, and GABA type A receptor activation may play a role in their regulation by steroids. Steroids 160-168 gonadotropin releasing hormone 1 Mus musculus 0-4 32587659-9 2020 Furthermore, BMP4 prevented follicular atresia by promoting production of steroid hormones to improve survival of GCs in PHFs from the aged hens. Steroids 74-81 bone morphogenetic protein 4 Gallus gallus 13-17 32627495-6 2020 It was found that 35 absorbed components of Gardeniae Fructus not only regulated 48 targets such as cholines-terase(BCHE) and carbonic anhydrase 2(CA2), but also affected 11 biological processes(e.g. transcription factor activity, nuclear receptor activity, steroid hormone receptor activity, amide binding and peptide binding) and 7 metabolic pathways(MAPK signaling pathway, Alzheimer disease and estrogen signaling pathway, etc.). Steroids 258-265 carbonic anhydrase 2 Homo sapiens 147-150 15096602-10 2004 The ability of prenatal steroid exposure to initiate changes that alter functional inputs to GnRH neurons in adults has important implications for understanding the regulation of normal reproduction as well as the hypothalamic abnormalities of fertility disorders. Steroids 24-31 gonadotropin releasing hormone 1 Mus musculus 93-97 15042616-3 2004 METHODS: In our study we tested the growth ability of the LNCaP human prostatic cell line in steroid-free culture conditions in response to osteopontin (OPN), a non-collageneous matrix protein, localized in large amounts in the bone. Steroids 93-100 secreted phosphoprotein 1 Homo sapiens 140-151 31853550-4 2020 METHODS AND RESULTS: We measured circulating concentrations of GDF15 in a cohort of Addison"s disease patients following steroid withdrawal and healthy volunteers. Steroids 121-128 growth differentiation factor 15 Homo sapiens 63-68 15042616-3 2004 METHODS: In our study we tested the growth ability of the LNCaP human prostatic cell line in steroid-free culture conditions in response to osteopontin (OPN), a non-collageneous matrix protein, localized in large amounts in the bone. Steroids 93-100 secreted phosphoprotein 1 Homo sapiens 153-156 32238415-0 2020 Steroid activation of TRPM3 channels modulates spontaneous synaptic activity but not retinal waves in the developing retina. Steroids 0-7 transient receptor potential cation channel, subfamily M, member 3 Mus musculus 22-27 15046863-2 2004 It is known that in non-neuronal cells, the GFP-GR moves from cytoplasm to the nucleus in a steroid-dependent manner by a rapid, hsp90-dependent mechanism. Steroids 92-99 heat shock protein 90 alpha family class A member 1 Homo sapiens 129-134 31870594-2 2020 Thus, we aimed to explore the associations of steroid-5alpha-reductase type 1 (SRD5A1) gene polymorphism with impaired fasting glucose (IFG) and T2DM and the interactive effects of testosterone and genotypes on glycometabolism. Steroids 46-53 steroid 5 alpha-reductase 1 Homo sapiens 79-85 15057901-13 2004 Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification. Steroids 126-134 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 33-39 32352317-3 2020 The steroid and xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] is a nuclear hormone receptor that regulates inducible metabolism of drugs and xenobiotics and is activated or inhibited by various PCB congeners. Steroids 4-11 nuclear receptor subfamily 1, group I, member 2 Mus musculus 60-79 32352317-3 2020 The steroid and xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] is a nuclear hormone receptor that regulates inducible metabolism of drugs and xenobiotics and is activated or inhibited by various PCB congeners. Steroids 4-11 nuclear receptor subfamily 1, group I, member 2 Mus musculus 81-84 15072555-1 2004 The steroidogenic acute regulatory (StAR) protein promotes intramitochondrial delivery of cholesterol to the cholesterol side-chain cleavage system, which catalyzes the first enzymatic step in all steroid synthesis. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 36-40 32352317-3 2020 The steroid and xenobiotic receptor [SXR; also known as the pregnane X receptor (PXR) and formally known as NR1I2] is a nuclear hormone receptor that regulates inducible metabolism of drugs and xenobiotics and is activated or inhibited by various PCB congeners. Steroids 4-11 nuclear receptor subfamily 1, group I, member 2 Mus musculus 108-113 15072555-10 2004 Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body. Steroids 39-46 steroidogenic acute regulatory protein Mus musculus 83-87 15072555-10 2004 Secondly, through direct conversion to steroid, oxysterols may account in part for StAR-independent steroid production in the body. Steroids 100-107 steroidogenic acute regulatory protein Mus musculus 83-87 31845319-5 2020 GSTE14 has high-ranking steroid double-bond isomerase activity, albeit 50-fold lower than the most efficient mammalian GSTs. Steroids 24-31 Glutathione S transferase E14 Drosophila melanogaster 0-6 31845319-7 2020 Nonetheless, the essential enzyme GSTE14 is here demonstrated to be catalytically competent and have a steroid-binding site. Steroids 103-110 Glutathione S transferase E14 Drosophila melanogaster 34-40 31978584-6 2020 CSF CXCL13 levels did not change significantly in children with TBE meningitis receiving supportive treatment, but decreased in children with TBE meningoencephalitis who received intravenous steroids. Steroids 191-199 C-X-C motif chemokine ligand 13 Homo sapiens 4-10 15044598-7 2004 It seems likely that binding of either c-Myb or c-Ets to FP12 is necessary for the direct or indirect binding of the hGR to FP11 (a nonconsensus glucocorticoid response element), and the resultant steroid-responsiveness of the hGR 1A promoter/exon sequence. Steroids 197-204 MYB proto-oncogene, transcription factor Homo sapiens 39-44 14670990-3 2004 IGFBP-3 has been shown to be cleaved by members of the kallikrein family, some of which are expressed in human thyroid and are characterized by regulation by steroid hormones. Steroids 158-174 insulin like growth factor binding protein 3 Homo sapiens 0-7 15147234-0 2004 Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles. Steroids 76-83 leptin Homo sapiens 33-39 31948671-1 2020 Sex steroid hormones and neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), play a significant neuroprotective role in memory circuitry aging. Steroids 4-11 brain derived neurotrophic factor Homo sapiens 55-88 31948671-1 2020 Sex steroid hormones and neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), play a significant neuroprotective role in memory circuitry aging. Steroids 4-11 brain derived neurotrophic factor Homo sapiens 90-94 31990666-9 2020 Moreover, ESR1 (steroid receptors) gene expression was downregulated (P=0.057) in CA from placentitis mares. Steroids 16-23 estrogen receptor 1 Equus caballus 10-14 14694143-6 2004 This current displayed a higher apparent Na(+) affinity in pumps containing human alpha2 subunits (10 mM) than in pumps containing human alpha1 (33.2 mM) or endogenous (cardiotonic steroid-resistant) mouse alpha1 subunits (mean: 16.3 mM). Steroids 181-188 adrenoceptor alpha 1D Homo sapiens 206-212 14696093-3 2004 We describe the effect of steroid hormones on the protein level of p66(Shc) and growth stimulation in hormone-sensitive human prostate, testicular and breast cancer cells. Steroids 26-33 DNA polymerase delta 3, accessory subunit Homo sapiens 67-70 32019875-1 2020 OBJECTIVE: Autoimmune steroid-responsive meningoencephalomyelitis with linear perivascular gadolinium enhancement in brain MRI is regarded as glial fibrillary acidic protein (GFAP) astrocytopathy characterized by anti-GFAP antibodies (ABs). Steroids 22-29 glial fibrillary acidic protein Homo sapiens 142-173 32019875-1 2020 OBJECTIVE: Autoimmune steroid-responsive meningoencephalomyelitis with linear perivascular gadolinium enhancement in brain MRI is regarded as glial fibrillary acidic protein (GFAP) astrocytopathy characterized by anti-GFAP antibodies (ABs). Steroids 22-29 glial fibrillary acidic protein Homo sapiens 175-179 32019875-1 2020 OBJECTIVE: Autoimmune steroid-responsive meningoencephalomyelitis with linear perivascular gadolinium enhancement in brain MRI is regarded as glial fibrillary acidic protein (GFAP) astrocytopathy characterized by anti-GFAP antibodies (ABs). Steroids 22-29 glial fibrillary acidic protein Homo sapiens 218-222 14696093-9 2004 The data collectively indicate that p66(Shc) protein levels correlate with steroid hormone-stimulated cell growth and prostate carcinogenesis. Steroids 75-90 DNA polymerase delta 3, accessory subunit Homo sapiens 36-39 32019875-13 2020 This supports the hypothesis that the clinical spectrum of steroid-responsive meningoencephalomyelitis suggestive of autoimmune GFAP astrocytopathy may be broader and may comprise also seronegative cases. Steroids 59-66 glial fibrillary acidic protein Homo sapiens 128-132 14568914-4 2004 Estradiol induced a significant reduction in uterine TIMP-3 expression in wild-type mice at 8 and 24 h post-steroid administration, but the ability of this steroid to decrease TIMP-3 expression was impaired in the uteri of TIMP-1 null mice. Steroids 156-163 tissue inhibitor of metalloproteinase 3 Mus musculus 176-182 31626910-13 2020 Circulatory C11-oxy C19 steroids levels were also significantly higher (8-fold) than the C11-oxy C21 steroid levels, while the former were similar to the C19 steroid levels, in contrast to levels in PCa. Steroids 24-32 aldo-keto reductase family 1 member C4 Homo sapiens 12-15 31626910-13 2020 Circulatory C11-oxy C19 steroids levels were also significantly higher (8-fold) than the C11-oxy C21 steroid levels, while the former were similar to the C19 steroid levels, in contrast to levels in PCa. Steroids 24-31 aldo-keto reductase family 1 member C4 Homo sapiens 12-15 14568914-7 2004 These observations suggest that steroids induce uterine TIMP-1 expression and, in turn, that TIMP-1 influences TIMP-3 mRNA expression and uterine edema. Steroids 32-40 tissue inhibitor of metalloproteinase 3 Mus musculus 111-117 31626910-14 2020 The study highlights the contribution of adrenal C11-oxy steroids to the androgen pool in BPH underscoring their limited reactivation and elimination, and significant inter-individual variations regarding steroid levels and conjugation. Steroids 57-64 aldo-keto reductase family 1 member C4 Homo sapiens 49-52 15499829-5 2004 Serum steroids differentially regulate the expression of PKC isoenzymes in LNCaP and PC3 cells. Steroids 6-14 proprotein convertase subtilisin/kexin type 1 Homo sapiens 85-88 31560992-7 2020 RESULTS: Daucosterol (CA2), a steroid saponin, was identified as major anticancer principle of the C. adansonii extract. Steroids 30-37 carbonic anhydrase 2 Homo sapiens 22-25 14592955-3 2004 The mRNA levels of steroidogenic acute regulatory protein or P450 steroid side-chain cleavage enzyme, the rate-limiting steps of adrenocortical steroidogenesis, were enhanced by activin and BMP-6. Steroids 19-26 inhibin subunit beta E Homo sapiens 178-185 14742980-9 2004 We also showed that all of the 10 patients with increasing levels of granzyme B, perforin, and FasL during steroid treatment demonstrated persistent or deteriorating GVHD. Steroids 107-114 granzyme B Homo sapiens 69-79 31980477-1 2020 Rituximab (375 mg/m2) achieved remission of the first episode and six relapses of nephrotic syndrome (NS) in a young male patient with podocyte phospholipase A2 receptor (PLA2R)-related membranous nephropathy (MN) refractory to steroids and cyclosporine. Steroids 228-236 phospholipase A2 receptor 1 Homo sapiens 144-169 31980477-1 2020 Rituximab (375 mg/m2) achieved remission of the first episode and six relapses of nephrotic syndrome (NS) in a young male patient with podocyte phospholipase A2 receptor (PLA2R)-related membranous nephropathy (MN) refractory to steroids and cyclosporine. Steroids 228-236 phospholipase A2 receptor 1 Homo sapiens 171-176 15242338-3 2004 The hsp90-/hsp70-based chaperone machinery interacts with the unliganded glucocorticoid receptor to open the steroid-binding cleft to access by a steroid, and the machinery interacts in very dynamic fashion with the liganded, transformed receptor to facilitate its translocation along microtubular highways to the nucleus. Steroids 109-116 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 31711705-3 2020 The aim of this study is to investigate the role of AMH as a regulator of the basal and stimulated steroid production by pig granulosa cells (pGCs) and theca cells (pTCs). Steroids 99-106 muellerian-inhibiting factor Sus scrofa 52-55 15242338-3 2004 The hsp90-/hsp70-based chaperone machinery interacts with the unliganded glucocorticoid receptor to open the steroid-binding cleft to access by a steroid, and the machinery interacts in very dynamic fashion with the liganded, transformed receptor to facilitate its translocation along microtubular highways to the nucleus. Steroids 146-153 heat shock protein 90 alpha family class A member 1 Homo sapiens 4-9 14709150-8 2004 Steroid production was significantly increased when both HO-1 and HO-2 activities were inhibited by Sn-protoporphyrin IX (SnPPIX). Steroids 0-7 heme oxygenase 2 Mus musculus 66-70 15456935-7 2004 We found that SRC-1 overexpressing cells are more responsive to Po mRNA induction by DHP, whereas the effect of the steroid is completely lost in SRC-1-deficient cells. Steroids 116-123 nuclear receptor coactivator 1 Rattus norvegicus 146-151 31936362-6 2020 The levels of estradiol and progesterone, and the expression of genes associated with steroid production, such as CYP11A1 (cytochrome P450 family 11), 3beta-HSD (3beta-hydroxysteroid dehydrogenase), StAR (steroidogenic acute regulatory protein), and CYP19A1 (cytochrome P450 family 19 subfamily a member 1), were all significantly higher in the Dox (-) group than Dox (+) group. Steroids 86-93 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 151-160 14644813-3 2003 Endometrial and placental CRH is under the endocrine control of gonadal steroids as well as under an autocrine/paracrine regulation by prostanoids and interleukins. Steroids 72-80 corticotropin releasing hormone Homo sapiens 26-29 32200378-13 2020 Furthermore, the ANXA1-high group had significantly more locally restricted disease (p = 0.0070), more stricturating disease (p = 0.0037), and was less frequently treated by preoperative steroid therapy (p = 0.030). Steroids 187-194 annexin A1 Homo sapiens 17-22 14560019-5 2003 Furthermore, our results indicate that overexpression of SRC-3 can modulate the AKT signaling pathway in a steroid-independent manner, which results in the activation of AKT/mTOR signaling concomitant with an increase in cell size. Steroids 107-114 nuclear receptor coactivator 3 Homo sapiens 57-62 31865316-7 2020 Taxifolin competitively inhibited rat AKR1C9 against steroid dihydrotestosterone (DHT), and docking analysis revealed that taxifolin bound to the steroid binding site of rat AKR1C9 with similar free energy with the substrate DHT. Steroids 146-153 aldo-keto reductase family 1, member C14 Rattus norvegicus 174-180 14669422-3 2003 Beside steroids, the influence on CRH release may be modulated by cytokines, especially interleukin 1 (IL-1) and interleukin 6 (IL-6). Steroids 7-15 corticotropin releasing hormone Homo sapiens 34-37 14533137-11 2003 Altered regulation of NPY, either through abnormal leptin control or serotonin blockade, is a possible explanation for the effects of AP medication on both weight and gonadal steroid levels. Steroids 175-182 neuropeptide Y Homo sapiens 22-25 32270742-0 2020 Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. Steroids 83-90 sirtuin 1 Homo sapiens 59-68 32270742-4 2020 We hypothesized that SIRT1 is reduced in these cells in COPD, and that treatment with SIRT1 activators (resveratrol, curcumin) and agents preventing NAD depletion (theophylline) would upregulate SIRT1 and reduce pro-inflammatory cytokine expression in these steroid-resistant cells. Steroids 258-265 sirtuin 1 Homo sapiens 86-91 32270742-4 2020 We hypothesized that SIRT1 is reduced in these cells in COPD, and that treatment with SIRT1 activators (resveratrol, curcumin) and agents preventing NAD depletion (theophylline) would upregulate SIRT1 and reduce pro-inflammatory cytokine expression in these steroid-resistant cells. Steroids 258-265 sirtuin 1 Homo sapiens 86-91 32270742-9 2020 Loss of SIRT1 was associated with increased production of IFNgamma and TNFalpha, steroid resistance, and disease severity. Steroids 81-88 sirtuin 1 Homo sapiens 8-13 32270742-10 2020 SIRT1 expression was upregulated in the presence of all drugs and was associated with a decrease in steroid resistance and IFNgamma and TNFalpha production by CD28nullCD8+T and NKT-like cells. Steroids 100-107 sirtuin 1 Homo sapiens 0-5 12807878-0 2003 Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. Steroids 144-151 heat shock protein 90 alpha family class A member 1 Homo sapiens 113-118 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 174-181 heat shock protein 90 alpha family class A member 1 Homo sapiens 35-40 31799643-1 2019 OBJECTIVE: The aim of this study was to explore the role of micro ribonucleic acid (miR)-15b in steroid-induced osteonecrosis of the femoral head (SONFH) and its potential mechanism. Steroids 96-103 microRNA 15b Homo sapiens 60-92 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 174-181 stress induced phosphoprotein 1 Homo sapiens 49-52 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 174-181 prostaglandin E synthase 3 Homo sapiens 65-68 31655797-5 2019 Steroid SULT gene-upregulated ccRCC cases showed mutual exclusivity with mutations of VHL, SETD2 and PBRM1, and with focal deletions of 3p and 9p, respectively. Steroids 0-7 polybromo 1 Homo sapiens 101-106 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 174-181 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 209-216 heat shock protein 90 alpha family class A member 1 Homo sapiens 35-40 31190361-0 2019 The role of lncRNA RP11-154D6 in steroid-induced osteonecrosis of the femoral head through BMSC regulation. Steroids 33-40 pre-mRNA processing factor 31 Homo sapiens 19-23 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 209-216 stress induced phosphoprotein 1 Homo sapiens 49-52 31190361-10 2019 CONCLUSIONS: Our results demonstrated that lncRNA RP11-154D6 might contribute to the progression of steroid-induced ONFH through regulating the behavior of BMSCs and might provide new insights into the pathogenesis as well as treatment for steroid-induced ONFH. Steroids 100-107 pre-mRNA processing factor 31 Homo sapiens 50-54 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 209-216 prostaglandin E synthase 3 Homo sapiens 65-68 31190361-10 2019 CONCLUSIONS: Our results demonstrated that lncRNA RP11-154D6 might contribute to the progression of steroid-induced ONFH through regulating the behavior of BMSCs and might provide new insights into the pathogenesis as well as treatment for steroid-induced ONFH. Steroids 240-247 pre-mRNA processing factor 31 Homo sapiens 50-54 31432121-0 2019 Ginsenoside Rb1 prevents steroid-induced avascular necrosis of the femoral head through the bone morphogenetic protein-2 and vascular endothelial growth factor pathway. Steroids 25-32 RB transcriptional corepressor 1 Rattus norvegicus 12-15 31432121-2 2019 The present study was designed to investigate whether Ginsenoside Rb1 weakened the steroid-induced avascular necrosis of the femoral head (SANFH) and to explore the possible mechanisms of the above effects. Steroids 83-90 RB transcriptional corepressor 1 Rattus norvegicus 66-69 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 209-216 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 12773401-2 2003 Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. Steroids 129-137 matrix metallopeptidase 1 Homo sapiens 60-64 31432121-3 2019 As a result, it was revealed that Ginsenoside Rb1 was protective against steroid-induced avascular necrosis and inhibited serum osteocalcin in a rat model of SANFH. Steroids 73-80 RB transcriptional corepressor 1 Rattus norvegicus 46-49 12938026-1 2003 The peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a member of the steroid hormone super family of ligand-inducible transcription factors, involved in glucose and lipid metabolism. Steroids 85-92 peroxisome proliferator activated receptor alpha Homo sapiens 4-52 31196727-8 2019 After steroid pulse therapy (combined with plasmapheresis in 32% of patients in AQP4-Ab-positive group), median VA improved to 0.4 logMAR in the AQP4-Ab-positive group, 0 logMAR in the MOG-Ab-positive group, and 0.1 logMAR in the double-negative group. Steroids 6-13 aquaporin 4 Homo sapiens 80-84 12938026-1 2003 The peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a member of the steroid hormone super family of ligand-inducible transcription factors, involved in glucose and lipid metabolism. Steroids 85-92 peroxisome proliferator activated receptor alpha Homo sapiens 54-64 31196727-8 2019 After steroid pulse therapy (combined with plasmapheresis in 32% of patients in AQP4-Ab-positive group), median VA improved to 0.4 logMAR in the AQP4-Ab-positive group, 0 logMAR in the MOG-Ab-positive group, and 0.1 logMAR in the double-negative group. Steroids 6-13 aquaporin 4 Homo sapiens 145-149 12915603-3 2003 Like other kallikreins, KLK15 is regulated by steroid hormones in cancer cell lines. Steroids 46-62 kallikrein related peptidase 15 Homo sapiens 24-29 31220580-2 2019 The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERalpha) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1alpha), and obesity that has been recognized as a EC risk factor. Steroids 158-165 snail family transcriptional repressor 2 Homo sapiens 306-310 12783319-0 2003 Epithelial cells in the oviduct and vagina and steroid-synthesizing cells in the rabbit ovary express AhR and ARNT. Steroids 47-54 aryl hydrocarbon receptor nuclear translocator Oryctolagus cuniculus 110-114 31389574-0 2019 Role of Hsa-miR-122-3p in steroid-induced necrosis of femoral head. Steroids 26-33 microRNA 122 Homo sapiens 8-19 12677006-8 2003 These data suggest that rat GST-1 and GST-2 might be one of the molecular entities responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of sex steroid transportation and spermatogenesis in the gonad. Steroids 198-205 solute carrier organic anion transporter family member 6B1 Rattus norvegicus 28-33 31389574-1 2019 OBJECTIVE: To explore the clinical correlation between the hsa-miR-122-3p expression in bone marrow mesenchymal stem cells (BMSCs) and steroid-induced necrosis of femoral head (SONFH). Steroids 135-142 microRNA 122 Homo sapiens 59-70 30660639-1 2019 BACKGROUND: CD8+ type 2 cytotoxic T (TC2) cells undergo transcriptional reprogramming to IL-13 production in the presence of IL-4 to become potent, steroid-insensitive, pathogenic effector cells in asthmatic patients and in mice in a model of experimental asthma. Steroids 148-155 CD8a molecule Homo sapiens 12-15 12702733-1 2003 The glucocorticoid-modulatory element-binding proteins, GMEB1 and GMEB2, are ubiquitous, multifunctional DNA-binding proteins with important roles in the modulation of transcription upon steroid hormone activation. Steroids 187-202 glucocorticoid modulatory element binding protein 2 Homo sapiens 66-71 12815006-3 2003 Several polymorphisms have been identified in the steroid 5 alpha-reductase type II gene (SRD5A2), which encodes an enzyme that catalyzes the conversion of testosterone to its more potent metabolite, dihydrotestosterone. Steroids 50-57 steroid 5 alpha-reductase 2 Homo sapiens 90-96 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Steroids 71-78 progesterone receptor Mus musculus 104-125 31566189-4 2019 In addition, cells were treated with mifepristone (RU486), a synthetic steroid that has an affinity for progesterone receptor (Pgr), for one day starting on day 11. Steroids 71-78 progesterone receptor Mus musculus 127-130 30939354-8 2019 On the other hand, deprivation of testicular steroids, especially androstenone and 17beta-estradiol accelerated skatole degradation metabolism in the liver by increasing (P < 0.05) hepatic CYP2E1, CYP2A, CYP2C49 and CYB5A expressions. Steroids 45-53 cytochrome b5 type A Sus scrofa 219-224 12746312-4 2003 We investigated whether steroid hormones interfere with PTH signaling by modulating PTH-induced RGS-2 expression in osteoblast-like UMR 106-01 cells. Steroids 24-40 regulator of G-protein signaling 2 Rattus norvegicus 96-101 31137813-4 2019 Both serum amyloid A (SAA) and IL-33 have been implicated in the pathology of steroid-resistant lung inflammation. Steroids 78-85 serum amyloid A1 cluster Homo sapiens 5-20 12746312-11 2003 Regulation of RGS-2 may constitute a novel mechanism by which steroids modulate signaling via the PTH/PTHrP receptor and other G protein-coupled receptors in bone. Steroids 62-70 regulator of G-protein signaling 2 Rattus norvegicus 14-19 31137813-4 2019 Both serum amyloid A (SAA) and IL-33 have been implicated in the pathology of steroid-resistant lung inflammation. Steroids 78-85 serum amyloid A1 cluster Homo sapiens 22-25 12692076-1 2003 A mouse protein that interacts with the peripheral-type benzodiazepine receptor (PBR) and cAMP-dependent protein kinase A (PKA) regulatory subunit RIalpha (PRKAR1A), named PBR and PKA-associated protein 7 (PAP7), was identified and shown to be involved in hormone-induced steroid biosynthesis. Steroids 272-279 protein kinase, cAMP dependent regulatory, type I, alpha Mus musculus 156-163 31137813-12 2019 Our results suggest that picroside II negatively modulates the SAA-IL-33 axis that has been implicated in steroid-resistant lung inflammation. Steroids 106-113 serum amyloid A1 cluster Homo sapiens 63-66 12897402-6 2003 Up-regulation of HSP90, a steroid receptor chaperone, in the AD CP may indicate abnormal hormone receptor expression in this secretory tissue. Steroids 26-33 heat shock protein 90 alpha family class A member 1 Homo sapiens 17-22 31010479-1 2019 Recently, recessive mutations of MAGI2 were identified as a cause of steroid-resistant nephrotic syndrome (SRNS) in humans and mice. Steroids 69-76 membrane associated guanylate kinase, WW and PDZ domain containing 2 Homo sapiens 33-38 30689188-1 2019 The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized mouse models of menopause. Steroids 157-173 staufen double-stranded RNA binding protein 1 Mus musculus 71-76 12943718-3 2003 It is important to highlight that the mechanisms by which neuroactive steroids exert their effects on the expression of Po and PMP22 involve different kind of receptors depending on the steroid and on the myelin protein considered. Steroids 70-78 peripheral myelin protein 22 Homo sapiens 127-132 12943718-3 2003 It is important to highlight that the mechanisms by which neuroactive steroids exert their effects on the expression of Po and PMP22 involve different kind of receptors depending on the steroid and on the myelin protein considered. Steroids 70-77 peripheral myelin protein 22 Homo sapiens 127-132 12943718-5 2003 Because Po and PMP22 play an important physiological role for the maintenance of the multilamellar structure of the myelin of the PNS, the present observations might suggest the utilization of neuroactive steroids as new therapeutically approaches for the rebuilding of the peripheral myelin. Steroids 205-213 peripheral myelin protein 22 Homo sapiens 15-20 12764114-12 2003 Thus, osmotic modulation of ER-beta expression in MNCs may augment or attenuate an inhibitory effect of gonadal steroids on VP release. Steroids 112-120 estrogen receptor 2 Rattus norvegicus 28-35 30690341-7 2019 CSF GFAP levels were significantly reduced after steroid treatment (p = 0.011). Steroids 49-56 glial fibrillary acidic protein Homo sapiens 4-8 30690341-12 2019 CSF GFAP level was associated with steroid treatment at the acute stage, therefore CSF GFAP may be a sensitive biomarker with respect to the effects of therapy during the acute stage. Steroids 35-42 glial fibrillary acidic protein Homo sapiens 4-8 30690341-12 2019 CSF GFAP level was associated with steroid treatment at the acute stage, therefore CSF GFAP may be a sensitive biomarker with respect to the effects of therapy during the acute stage. Steroids 35-42 glial fibrillary acidic protein Homo sapiens 87-91 12887177-6 2003 Surprisingly, it was found that ovarian stromal tissue cGPX4 expression is regulated quite differently according to the reproductive status of the bird, suggesting that GPX4 may play an important role in reproduction in response to steroid hormones, in addition to its general antioxidant functions. Steroids 232-239 glutathione peroxidase 4 Gallus gallus 56-60 30814257-0 2019 Plants on (Brassino)steroids: Degradation of the Transcription Factor BZR1 by the E3 Ubiquitin Ligase PUB40. Steroids 20-28 Cbl proto-oncogene like 2 Homo sapiens 82-101 12606484-1 2003 The aim of the present study was to examine the acute and chronic effects of the gonadotropin-releasing hormone agonist (GnRH-a) leuprolide acetate (LA) on the expression of the steroidogenic acute regulatory protein (StAR), the cytochrome P450 side-chain cleavage enzyme (P450scc), and steroid production in antral ovarian follicles obtained from prepubertal equine choriogonadotropin (eCG)-treated rats. Steroids 178-185 cytochrome P450 family 11 subfamily A member 1 Equus caballus 273-280 12879993-3 2003 Other drugs that occasionally cause steatohepatitis, most importantly steroid hormones, likely exacerbate the pathogenetic mechanisms leading to NASH. Steroids 70-86 SAM domain, SH3 domain and nuclear localization signals 1 Homo sapiens 145-149 30983748-0 2019 Loss of Subpodocytic Space Predicts Poor Response to Tacrolimus in Steroid-Resistant Calcineurin Inhibitor-Naive Adult-Onset Primary Focal Segmental Glomerulosclerosis. Steroids 67-74 calcineurin binding protein 1 Homo sapiens 85-106 30983748-4 2019 Diagnostic biopsies of adult-onset steroid-resistant calcineurin inhibitor-naive primary FSGS cases, which were subsequently treated with tacrolimus were included in this retrospective study conducted from 2011 to 2013. Steroids 35-42 calcineurin binding protein 1 Homo sapiens 53-74 12736327-12 2003 These results showed that neuroactive steroids play a role in cocaine-induced appetence, through their interaction with the sigma1 receptor. Steroids 38-46 sigma non-opioid intracellular receptor 1 Mus musculus 124-139 30763313-7 2019 This is consistent with transcript levels of enzymes involved in the alternate pathway (steroid 5alpha-reductase type 1 [SRD5A1], aldo-keto reductase type 1C2 [AKR1C2], aldo-keto reductase type 1C4 [AKR1C4], cytochrome P450 17A1 [CYP17A1]), as measured by quantitative PCR (qPCR). Steroids 88-95 steroid 5 alpha-reductase 1 Homo sapiens 121-127 12589649-3 2003 The present study was undertaken to determine the c-fos and estrogen receptor (ER) gene expression pattern in the rat uterine epithelium during the estrous cycle in which natural and cyclic changes of steroid hormones occur, and correlate these changes with the proliferation status of this cellular types. Steroids 201-217 estrogen receptor 1 Rattus norvegicus 79-81 30425102-1 2019 Human cytochrome P450 11B1 (CYP11B1) is responsible for the final step generating the steroid hormone cortisol, which controls stress and immune responses and glucose homeostasis. Steroids 86-101 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 6-26 12605208-12 2003 An empiric dose of 10 vials of digoxin-specific Fab might be beneficial in patients poisoned with an unknown cardioactive steroid. Steroids 122-129 FA complementation group B Homo sapiens 48-51 30425102-1 2019 Human cytochrome P450 11B1 (CYP11B1) is responsible for the final step generating the steroid hormone cortisol, which controls stress and immune responses and glucose homeostasis. Steroids 86-101 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 28-35 30031147-5 2019 The recombinant form of DHRS1 was purified using the detergent n-dodecyl-beta-D-maltoside, and DHRS1 was proven to be an NADPH-dependent reductase that is able to catalyse the in vitro reductive conversion of some steroids (estrone, androstene-3,17-dione and cortisone), as well as other endogenous substances and xenobiotics. Steroids 214-222 dehydrogenase/reductase 1 Homo sapiens 24-29 12620484-0 2003 Effect of female sex steroids on human endometrial CD16neg CD56bright natural killer cells. Steroids 21-29 neural cell adhesion molecule 1 Homo sapiens 59-63 30031147-5 2019 The recombinant form of DHRS1 was purified using the detergent n-dodecyl-beta-D-maltoside, and DHRS1 was proven to be an NADPH-dependent reductase that is able to catalyse the in vitro reductive conversion of some steroids (estrone, androstene-3,17-dione and cortisone), as well as other endogenous substances and xenobiotics. Steroids 214-222 dehydrogenase/reductase 1 Homo sapiens 95-100 30031147-6 2019 The expression pattern and enzyme activities fit to a role in steroid and/or xenobiotic metabolism; however, more research is needed to fully clarify the exact biological function of DHRS1. Steroids 62-69 dehydrogenase/reductase 1 Homo sapiens 183-188 12604236-2 2003 Comparison of kinetic constants for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the neuroactive steroids in the human brain. Steroids 52-60 aldo-keto reductase family 1 member C1 Homo sapiens 141-154 12604236-2 2003 Comparison of kinetic constants for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the neuroactive steroids in the human brain. Steroids 52-60 aldo-keto reductase family 1 member C1 Homo sapiens 141-147 29796990-1 2019 Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain. Steroids 78-86 sulfotransferase family 2A member 1 Homo sapiens 32-37 29796990-4 2019 The decline of DHEAS level was associated with age-related neuronal dysfunction and degeneration, most probably because the steroids protect the central nervous system (CNS) neurons against neurotoxic challenges. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 15-20 12604236-2 2003 Comparison of kinetic constants for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the neuroactive steroids in the human brain. Steroids 267-275 aldo-keto reductase family 1 member C1 Homo sapiens 141-154 12604236-2 2003 Comparison of kinetic constants for the neuroactive steroids and their precursors among four human 3(20)alpha-hydroxysteroid dehydrogenases (AKR1C1-AKR1C4) suggests that AKR1C1 and AKR1C2 are involved in the catabolism and synthesis, respectively, of the neuroactive steroids in the human brain. Steroids 267-275 aldo-keto reductase family 1 member C1 Homo sapiens 141-147 12605348-0 2003 Regulation of the VEGF-system in the endometrium during steroid-replacement and early pregnancy of pigs. Steroids 56-63 vascular endothelial growth factor A Sus scrofa 18-22 30648951-0 2018 Creation of Potent Vitamin D Receptor Agonists and Antagonists with 2alpha-(omega-Hydroxyalkylation) Concept to the seco-Steroid Skeleton. Steroids 121-128 vitamin D receptor Homo sapiens 19-37 12589391-2 2003 Since glucocorticoids exert a negative feedback at pituitary and supra-pituitary levels, the inhibition of steroid synthesis may lead to increased expression of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP). Steroids 107-114 corticotropin releasing hormone Homo sapiens 161-192 30348838-0 2019 Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis. Steroids 75-82 translocase of inner mitochondrial membrane 50 Homo sapiens 32-37 12589391-2 2003 Since glucocorticoids exert a negative feedback at pituitary and supra-pituitary levels, the inhibition of steroid synthesis may lead to increased expression of corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP). Steroids 107-114 corticotropin releasing hormone Homo sapiens 194-197 14610343-8 2003 In summary, steroids increase the absorption of lipids by a process which can be enhanced by the substitution of saturated for polyunsaturated lipids in the diet, and which is not explained by alterations in the expression of the mRNAs of L-FABP or ILBP. Steroids 12-20 fatty acid binding protein 6 Rattus norvegicus 249-253 30171708-2 2018 The aim of the study was to evaluate NPHS1 mutations, its susceptibility to the disease, and their association in children with steroid-resistant NS; mutation frequency of 9% was observed in patients with steroid-resistant NS, of which, six mutations and two single-nucleotide polymorphisms observed in the study population were found to be novel. Steroids 128-135 NPHS1 adhesion molecule, nephrin Homo sapiens 37-42 30171708-2 2018 The aim of the study was to evaluate NPHS1 mutations, its susceptibility to the disease, and their association in children with steroid-resistant NS; mutation frequency of 9% was observed in patients with steroid-resistant NS, of which, six mutations and two single-nucleotide polymorphisms observed in the study population were found to be novel. Steroids 205-212 NPHS1 adhesion molecule, nephrin Homo sapiens 37-42 12735109-2 2003 Other CYP forms have major roles in steroid, sterol, and bile acid metabolism. Steroids 36-43 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 6-9 30266830-0 2018 Growth control through regulation of insulin signalling by nutrition-activated steroid hormone in Drosophila. Steroids 79-94 Insulin-like receptor Drosophila melanogaster 37-44 12556907-11 2003 The molecular cloning and the highly specific expression of mTReP-132 across the brain further consolidate the hypothesis that this tissue is able to synthesize de novo steroids in a region-specific manner. Steroids 169-177 transcriptional regulating factor 1 Mus musculus 60-69 30266830-7 2018 The identification of trachea-dependent regulation of insulin signalling exposes an important variable that may have been overlooked in other studies focusing on insulin signalling in Drosophila Our findings provide a potentially conserved, novel mechanism by which nutrition can modulate steroid hormone bioactivation, reveal an important caveat of a commonly used transgenic tool to study insulin-producing cell function, and yield further insights into how steroid and insulin signalling are coordinated during development to regulate growth and developmental timing. Steroids 289-304 Insulin-like receptor Drosophila melanogaster 54-61 30266830-7 2018 The identification of trachea-dependent regulation of insulin signalling exposes an important variable that may have been overlooked in other studies focusing on insulin signalling in Drosophila Our findings provide a potentially conserved, novel mechanism by which nutrition can modulate steroid hormone bioactivation, reveal an important caveat of a commonly used transgenic tool to study insulin-producing cell function, and yield further insights into how steroid and insulin signalling are coordinated during development to regulate growth and developmental timing. Steroids 289-296 Insulin-like receptor Drosophila melanogaster 54-61 29709634-0 2018 Delineating the regulation of estrogen and androgen receptor expression by sex steroids during rat spermatogenesis. Steroids 79-87 androgen receptor Rattus norvegicus 43-60 12605306-12 2003 In addition, OAT3 interacted with sulfated steroid hormones such as estrone-3-sulfate. Steroids 43-59 solute carrier family 22 member 8 Homo sapiens 13-17 29751108-10 2018 Consequently we identified the presence of 11-beta-hydroxylase CYP11B1, which hydroxylates the respective steroid precursors to bioactive GC, in NPCs. Steroids 106-113 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 63-70 12718213-1 2003 AIM: To estimate leptin production in long-term steroid therapy, insulin resistance and obesity. Steroids 48-55 leptin Homo sapiens 17-23 12718213-5 2003 RESULTS: Leptin was highest in patients with bronchial asthma and steroids-induced diabetes mellitus, lower in patients with diabetes mellitus type 2 and obese controls while it was lowest in patients with atopic bronchial asthma. Steroids 66-74 leptin Homo sapiens 9-15 12718213-6 2003 CONCLUSION: Steroids and insulin resistance participate in the regulation of leptin production. Steroids 12-20 leptin Homo sapiens 77-83 14693164-7 2003 In addition, steroid therapy causes hypofibrinolytic state by dose-dependent increase in plasminogen activator inhibitor 1 (PAI-1) levels. Steroids 13-20 serpin family E member 1 Homo sapiens 89-122 14693164-7 2003 In addition, steroid therapy causes hypofibrinolytic state by dose-dependent increase in plasminogen activator inhibitor 1 (PAI-1) levels. Steroids 13-20 serpin family E member 1 Homo sapiens 124-129 12573822-6 2002 The expression of human androgen receptor (hAR) was confirmed by Western blot and steroid-binding assays on the whole cells. Steroids 82-89 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 43-46 12486153-0 2002 An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. Steroids 26-33 steroidogenic acute regulatory protein Mus musculus 49-87 12486153-5 2002 These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain. Steroids 61-68 steroidogenic acute regulatory protein Mus musculus 30-34 12435796-5 2002 LXR agonist treatment also altered expression of genes involved in steroid hormone synthesis and growth hormone receptor signaling, emphasizing a potential impact on endocrine function. Steroids 67-82 nuclear receptor subfamily 1, group H, member 2 Mus musculus 0-3 12441185-10 2002 Replacement of sex steroids to GDX rats restored the normal level of sex steroids, AR and ER. Steroids 19-27 estrogen receptor 1 Rattus norvegicus 90-92 12421978-3 2002 Previous studies have demonstrated that IL-2 can induce steroid resistance in mouse T cells. Steroids 56-63 interleukin 2 Mus musculus 40-44 12421978-5 2002 In the current study we found that the murine cell line (HT-2) is steroid resistant when incubated with IL-2, but steroid sensitive when grown in IL-4. Steroids 66-73 interleukin 2 Mus musculus 104-108 12421978-5 2002 In the current study we found that the murine cell line (HT-2) is steroid resistant when incubated with IL-2, but steroid sensitive when grown in IL-4. Steroids 114-121 interleukin 4 Mus musculus 146-150 12421978-8 2002 IL-2-induced steroid insensitivity in HT-2 cells appears to be a signaling event as the effects of IL-2 on nuclear translocation of the GCR occurred within 30 min even in the presence of cycloheximide. Steroids 13-20 interleukin 2 Mus musculus 0-4 12421978-12 2002 This study demonstrates a novel role for STAT5 in IL-2-induced steroid insensitivity. Steroids 63-70 signal transducer and activator of transcription 5A Mus musculus 41-46 12421978-12 2002 This study demonstrates a novel role for STAT5 in IL-2-induced steroid insensitivity. Steroids 63-70 interleukin 2 Mus musculus 50-54 12433965-2 2002 In order to address this question, the present study examined the effects of direct intrahypothalamic perfusions with leptin on the in vivo release of GnRH in ovarian steroid-primed ovariectomized rats utilizing the push-pull perfusion technique. Steroids 167-174 gonadotropin releasing hormone 1 Rattus norvegicus 151-155 12518246-2 2002 These peptides include adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP), endothelin-1, cerebellin, urotensin-II etc., and appear to be involved in the regulation of steroid hormone secretion and the proliferation of adrenocortical cells as autocrine and/or paracrine factors. Steroids 179-194 urotensin 2 Homo sapiens 113-125 12429813-6 2002 BALF MMP-8 was significantly converted to active form only in BALFs from steroid-naive and uncontrolled severe asthma patients, but not in BALFs from well-controlled asthma patients or healthy controls. Steroids 73-80 matrix metallopeptidase 8 Homo sapiens 5-10 12379440-7 2002 These results demonstrate a clear sexual dimorphism in the regulation of PR isoforms expression by sex steroid hormones in the rat brain, suggesting that this sex difference contributes to the sexually dimorphic effects of P in the rat brain. Steroids 103-110 progesterone receptor Rattus norvegicus 73-75 12239109-3 2002 The aims of the present study were to determine whether the NE and epinephrine neurons continue to express estrogen receptor (ER)-alpha in middle-aged rats; temporal expression of ER-alpha and cFos changes with age during the steroid-induced surge; and tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanol-N-methyltransferase mRNA content in catecholaminergic neurons of the brain stem changes during the surge with age. Steroids 226-233 estrogen receptor 1 Rattus norvegicus 180-188 12372000-11 2002 These findings suggest that differences in steroid secretion by the neonatal male and female gonads are responsible for producing sex differences in the level of PR expression in the postnatal MPN. Steroids 43-50 progesterone receptor Rattus norvegicus 162-164 12372566-5 2002 These data suggest that MAP2 is involved in the structural changes induced by E(2) and P(4) in the rat hippocampus, and that MAP2 expression is regulated by these steroid hormones at a postranscriptional level. Steroids 163-179 microtubule-associated protein 2 Rattus norvegicus 125-129 12093808-9 2002 The rate-limiting step is the ATP-dependent opening of the steroid binding cleft after hsp90 binding. Steroids 59-66 heat shock protein 90 alpha family class A member 1 Homo sapiens 87-92 12093808-11 2002 The reported specific inhibitors of the C-terminal ATP site on hsp90 inhibit the generation of steroid binding, but they have other effects in this multiprotein system that could explain the inhibition. Steroids 95-102 heat shock protein 90 alpha family class A member 1 Homo sapiens 63-68 12107170-0 2002 Upstream stimulatory factor (USF) is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta EF1. Steroids 54-69 upstream transcription factor 1 Homo sapiens 0-27 12107170-0 2002 Upstream stimulatory factor (USF) is recruited into a steroid hormone-triggered regulatory circuit by the estrogen-inducible transcription factor delta EF1. Steroids 54-69 upstream transcription factor 1 Homo sapiens 29-32 12411099-7 2002 It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD68, MCP-1, and MIP-1alpha, but had no effect on MIP-1beta in glomeruli with cellular crescents of patients with LN-CGN. Steroids 18-25 C-C motif chemokine ligand 2 Homo sapiens 105-110 29802557-10 2018 CONCLUSIONS: Additional apheresis therapy rapidly improves the visual acuity of steroid-resistant seropositive AQP4 ON. Steroids 80-87 aquaporin 4 Homo sapiens 111-115 12411099-7 2002 It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD68, MCP-1, and MIP-1alpha, but had no effect on MIP-1beta in glomeruli with cellular crescents of patients with LN-CGN. Steroids 18-25 C-C motif chemokine ligand 3 Homo sapiens 116-126 29688626-0 2018 Spin-labeled derivatives of cardiotonic steroids as tools for characterization of the extracellular entrance to the binding site on Na+ ,K+ -ATPase. Steroids 40-48 spindlin 1 Homo sapiens 0-4 12202413-2 2002 Cell adhesion molecules (CAMs) involved in leukocyte-endothelial interactions, e.g. intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, are regulated by sex steroids when expressed by cultured endothelium, while uterine and ovarian CAM expression appears to be cyclically or gonadotrophin-regulated. Steroids 208-216 selectin E Homo sapiens 175-185 12208674-3 2002 LRH is closely related to steroidogenic factor 1 (SF1; designated NR5A1), which is expressed in most steroidogenic tissues and regulates expression of several steroid-metabolizing enzymes. Steroids 26-33 nuclear receptor subfamily 5 group A member 1 Homo sapiens 66-71 29887962-0 2018 miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating microRNAs. Steroids 41-48 microRNA 215 Homo sapiens 27-36 29887962-8 2018 Similar to human plasma, the circulating levels of miR-10a-5p, miR-99a-5p and miR-21-5p were increased in steroid-treated rats independent of ONFH development. Steroids 106-113 microRNA 215 Homo sapiens 78-87 29887962-9 2018 The serum levels of miR-10a-5p, miR-99a-5p and miR-21-5p were increased by steroid treatment regardless of ONFH development in both humans and rats. Steroids 75-82 microRNA 215 Homo sapiens 47-56 12221114-9 2002 Overexpression of dominant-negative RasN17, addition of antisense Ki-rasA and inhibition of mitogen-activated protein kinase kinase also attenuated steroid-dependent increases in MAPK signaling. Steroids 148-155 RAS p21 protein activator 1 Mus musculus 69-73 29887962-10 2018 These data suggested that miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating miRNAs, but they are not specific for diagnosing steroid-induced ONFH. Steroids 67-74 microRNA 215 Homo sapiens 53-62 29887962-10 2018 These data suggested that miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating miRNAs, but they are not specific for diagnosing steroid-induced ONFH. Steroids 147-154 microRNA 215 Homo sapiens 53-62 29499168-1 2018 IL-17A is implicated in many aspects of pathogenesis of severe asthma, including inducing neutrophilic inflammation, airway hyperresponsiveness, steroid insensitivity and airway remodeling. Steroids 145-152 interleukin 17A Homo sapiens 0-6 12231117-1 2002 The enzyme steryl sulfatase may help support the growth of hormone-dependent tumors, including prostate cancers, by facilitating the conversion of circulating precursor steroids to active hormones. Steroids 169-177 steroid sulfatase Homo sapiens 11-27 12231117-3 2002 Intact LNCaP cultures had steryl sulfatase activity, as determined by conversion of [3H]estrone sulfate (E(1)S) to unconjugated steroids. Steroids 128-136 steroid sulfatase Homo sapiens 26-42 29352737-0 2018 Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8+ T cells. Steroids 130-137 CD8a molecule Homo sapiens 164-167 12124798-2 2002 We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and BT-20 human breast cancer cells and found that they were differentially regulated, with the cells showing variable responses to androgen. Steroids 27-42 kallikrein related peptidase 3 Homo sapiens 97-101 28951225-1 2018 Sodium-dependent organic anion transporter (SOAT) represents a membrane transporter specific for sulfated steroid hormones, which are supposed to participate in the regulation of reproductive processes. Steroids 106-122 solute carrier family 10 member 6 Homo sapiens 0-42 28951225-1 2018 Sodium-dependent organic anion transporter (SOAT) represents a membrane transporter specific for sulfated steroid hormones, which are supposed to participate in the regulation of reproductive processes. Steroids 106-122 solute carrier family 10 member 6 Homo sapiens 44-48 28951225-4 2018 The resulting decline of SOAT-mediated transport of sulfated steroids may participate in the impairment of functional spermatogenesis. Steroids 61-69 solute carrier family 10 member 6 Homo sapiens 25-29 28951227-0 2018 Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6). Steroids 13-20 solute carrier family 10 member 6 Homo sapiens 106-110 12036956-5 2002 We demonstrate that RalR1 exhibits an oxidoreductive catalytic activity toward retinoids, but not steroids, with at least an 800-fold lower apparent K(m) values for NADP+ and NADPH versus NAD+ and NADH as cofactors. Steroids 98-106 retinol dehydrogenase 11 Homo sapiens 20-25 28951227-0 2018 Transport of steroid 3-sulfates and steroid 17-sulfates by the sodium-dependent organic anion transporter SOAT (SLC10A6). Steroids 13-20 solute carrier family 10 member 6 Homo sapiens 112-119 28951227-1 2018 The sodium-dependent organic anion transporter SOAT/Soat shows highly specific transport activity for sulfated steroids. Steroids 111-119 solute carrier family 10 member 6 Homo sapiens 47-51 28951227-1 2018 The sodium-dependent organic anion transporter SOAT/Soat shows highly specific transport activity for sulfated steroids. Steroids 111-119 solute carrier family 10 member 6 Homo sapiens 52-56 28951227-4 2018 Therefore, we aimed to expand the substrate spectrum of SOAT and analyzed the SOAT-mediated transport of eight different sulfated steroids by combining in vitro transport experiments in SOAT-transfected HEK293 cells with LC-MS/MS analytics of cell lysates. Steroids 130-138 solute carrier family 10 member 6 Homo sapiens 78-82 28951227-4 2018 Therefore, we aimed to expand the substrate spectrum of SOAT and analyzed the SOAT-mediated transport of eight different sulfated steroids by combining in vitro transport experiments in SOAT-transfected HEK293 cells with LC-MS/MS analytics of cell lysates. Steroids 130-138 solute carrier family 10 member 6 Homo sapiens 78-82 28951227-8 2018 IN CONCLUSION: SOAT substrates from the group of sulfated steroids are characterized by a planar and lipophilic steroid backbone in trans-trans-trans conformation of the rings and a negatively charged mono-sulfate group at positions 3" or 17" with flexibility for alpha- or beta- orientation. Steroids 58-66 solute carrier family 10 member 6 Homo sapiens 15-19 28951227-8 2018 IN CONCLUSION: SOAT substrates from the group of sulfated steroids are characterized by a planar and lipophilic steroid backbone in trans-trans-trans conformation of the rings and a negatively charged mono-sulfate group at positions 3" or 17" with flexibility for alpha- or beta- orientation. Steroids 58-65 solute carrier family 10 member 6 Homo sapiens 15-19 12396554-1 2002 Insulin-like growth factor (IGF) binding protein 5 (IGFPB-5) is abundant in the uterus and is implicated in the sex steroid-induced growth of this tissue. Steroids 116-123 insulin-like growth factor binding protein 5 Rattus norvegicus 0-50 12106698-10 2002 The higher levels of PRL-R mRNA in female rats on proestrous suggest that PRL-R may be regulated by PRL or steroid hormones that show a surge on this day. Steroids 107-123 prolactin receptor Rattus norvegicus 21-26 12106698-10 2002 The higher levels of PRL-R mRNA in female rats on proestrous suggest that PRL-R may be regulated by PRL or steroid hormones that show a surge on this day. Steroids 107-123 prolactin receptor Rattus norvegicus 74-79 12095948-4 2002 Indeed, hEST1 may also be involved in the production of stable precursors for local steroid biosynthesis or in the activation of promutagenic estrogen metabolites into carcinogens. Steroids 84-91 sulfotransferase family 1E member 1 Homo sapiens 8-13 12050146-9 2002 Our study suggests that differences in radiation-induced p53 activity during post-natal mammary gland development are influenced by the proliferative state of the gland, and may be mediated indirectly by the mitogenic actions of steroid hormones in vivo. Steroids 229-245 transformation related protein 53 Mus musculus 57-60 12050120-1 2002 Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos. Steroids 21-28 sex determining region Y Homo sapiens 85-88 12051868-2 2002 In the cycling endometrium, interleukin-1alpha activity is controlled by sex steroids and is confined to the perimenstrual phase, where it is involved in the events leading to tissue lysis and menstruation. Steroids 77-85 interleukin 1 alpha Homo sapiens 28-46 11997017-4 2002 Although functional antagonism between steroid receptor and STAT6 for their transcriptional activity has been recently described, this is the first report that steroid inhibits the IL-4-induced STAT6 activity at the level of tyrosine phosphorylation and target DNA binding. Steroids 39-46 signal transducer and activator of transcription 6 Homo sapiens 194-199 11956172-4 2002 Our data revealed that many of the C17, C19, and C21 circulating steroids, at concentrations that are found in vivo, functioned as effective activators of the AR(ccr) but had little or no activity via the wild-type AR or GRalpha. Steroids 65-73 cytokine like 1 Homo sapiens 35-38 12028363-2 2002 Its precise endogenous ligand is not yet identified but the sigma(1) receptor appears to be one target for the nongenomic rapid effects of neuroactive steroids in the brain. Steroids 151-159 sigma non-opioid intracellular receptor 1 Mus musculus 60-77 12028363-3 2002 The aim of the present study was to establish whether differences in sigma(1) receptor-mediated behaviours could be observed among mouse strains, in relation with differences in either sigma(1) receptor expression or steroid levels. Steroids 217-224 sigma non-opioid intracellular receptor 1 Mus musculus 69-86 12028363-10 2002 Collectively, the results suggested that strain differences in neuroactive steroid and particularly, progesterone, biosynthesis and sensitivity may contribute to the differential behavioural efficacy of sigma(1)-receptor ligands. Steroids 75-82 sigma non-opioid intracellular receptor 1 Mus musculus 203-220 11948967-5 2002 Like KLK2 and KLK3, the KLK5 gene is regulated by steroid hormones in the BT-474 breast cancer cell line. Steroids 50-66 kallikrein related peptidase 3 Homo sapiens 14-18 12007288-0 2002 Control of uterine receptivity and embryo implantation by steroid hormone regulation of LIF production and LIF receptor activity: towards a molecular understanding of "the window of implantation". Steroids 58-73 LIF interleukin 6 family cytokine Homo sapiens 88-91 11982586-2 2002 In this study we have demonstrated that continuous injection of leptin prevents the reduction in lymphocyte numbers normally observed in fasted and steroid-injected mice. Steroids 148-155 leptin Mus musculus 64-70 14561202-10 2002 The gene coding for LTC4 synthase exists in two common alleles, one of which appears to be associated with a severe, steroid-dependent type of asthma. Steroids 117-124 leukotriene C4 synthase Homo sapiens 20-33 11861529-4 2002 We show that the recombinant hLHR can be expressed at variable densities in MA-10 cells and that it can stimulate cAMP and steroid synthesis as well as activate the inositol phosphate and MAPK cascades. Steroids 123-130 luteinizing hormone/choriogonadotropin receptor Homo sapiens 29-33 11874707-10 2002 The effects of FSK and the PTP inhibitors on cell rounding were reflected in their effects on steroid production since PV and CP also inhibited FSK-stimulated steroid production. Steroids 94-101 cell division cycle 25C Homo sapiens 27-30 11874707-10 2002 The effects of FSK and the PTP inhibitors on cell rounding were reflected in their effects on steroid production since PV and CP also inhibited FSK-stimulated steroid production. Steroids 159-166 cell division cycle 25C Homo sapiens 27-30 11882014-2 2002 In this study, the effect of diets designed to increase circulating insulin and insulin-like growth factor I (IGF-I) concentrations on steroid production by granulosa cells in vitro was examined to analyse the mechanisms through which these changes occur. Steroids 135-142 insulin Bos taurus 68-75 11882014-2 2002 In this study, the effect of diets designed to increase circulating insulin and insulin-like growth factor I (IGF-I) concentrations on steroid production by granulosa cells in vitro was examined to analyse the mechanisms through which these changes occur. Steroids 135-142 insulin Bos taurus 80-87 11861317-15 2002 The results indicate that it may be possible to develop therapeutic agents that target steroid modulatory sites of specific NMDA receptor subtypes. Steroids 87-94 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 124-137 11869378-1 2002 Steroid 5alpha-reductase deficiency is a rare autosomal recessive disorder caused by mutations in the SRD5A2-gene, resulting in diminished dihydrotestosterone (DHT) formation and, hence, in a severe virilization deficit of the external genitalia in patients with 46,XY karyotype. Steroids 0-7 steroid 5 alpha-reductase 2 Homo sapiens 102-108 12040892-9 2002 Steroids, given as therapy or secreted from the adrenal gland upon treatment with ACTH, decrease the production and release of CRH in certain brain regions. Steroids 0-8 corticotropin releasing hormone Homo sapiens 127-130 12698969-6 2002 Patterns of GnRH secretion and regulation by gonadal steroids have also been described in males. Steroids 53-61 Progonadoliberin-1 Ovis aries 12-16 12698975-9 2002 Broadly, our findings indicate that an extended period of steroid action on the developing brain programmes sex differences in GnRH secretion that are manifest later in life: in the expression of pulsatile GnRH release after birth or earlier; in its amplification during puberty; in its differential regulation during young adulthood. Steroids 58-65 Progonadoliberin-1 Ovis aries 127-131 12698975-9 2002 Broadly, our findings indicate that an extended period of steroid action on the developing brain programmes sex differences in GnRH secretion that are manifest later in life: in the expression of pulsatile GnRH release after birth or earlier; in its amplification during puberty; in its differential regulation during young adulthood. Steroids 58-65 Progonadoliberin-1 Ovis aries 206-210 12664659-5 2002 The CYP gene products such as CYP3A, CYP2B and PPAR are essential for metabolism of endogenous steroid hormones, fatty acids and various xenobiotics including drugs. Steroids 95-111 peroxisome proliferator activated receptor alpha Homo sapiens 47-51 11796315-1 2002 OBJECTIVES: Expression of glutathione S-transferase pi (GSTP1), a detoxification enzyme that also binds steroid hormones, is diminished or absent in human prostate tumors possibly because of promoter hypermethylation. Steroids 104-120 glutathione S-transferase pi 1 Homo sapiens 56-61 11795394-7 2001 The finding that certain hydroxylated polychlorinated biphenyls are potent inhibitors of the human estrogen sulfotransferase enzyme raises the possibility that environmental chemicals can cause endocrine disruption by enhancing endogenous estrogen activity through inhibition of steroid transformation enzymes such as estrogen sulfotransferase. Steroids 279-286 sulfotransferase family 1E member 1 Homo sapiens 99-124 11795394-7 2001 The finding that certain hydroxylated polychlorinated biphenyls are potent inhibitors of the human estrogen sulfotransferase enzyme raises the possibility that environmental chemicals can cause endocrine disruption by enhancing endogenous estrogen activity through inhibition of steroid transformation enzymes such as estrogen sulfotransferase. Steroids 279-286 sulfotransferase family 1E member 1 Homo sapiens 318-343 11744088-0 2001 Interactions between growth factors and steroids in the control of LHRH-secreting neurons. Steroids 40-48 gonadotropin releasing hormone 1 Rattus norvegicus 67-71 11744088-4 2001 On the basis of these results a possible functional correlation in the control of LHRH-secreting neurons between growth factors and gonadal steroids will be discussed and proposed. Steroids 140-148 gonadotropin releasing hormone 1 Rattus norvegicus 82-86 11744089-0 2001 Gonadotropin-releasing hormone neurons, NMDA receptors, and their regulation by steroid hormones across the reproductive life cycle. Steroids 80-96 gonadotropin releasing hormone 1 Rattus norvegicus 0-30 11744089-1 2001 The effects of ovarian steroid hormones on gonadotropin-releasing hormone (GnRH) neurons have been studied for many years. Steroids 23-39 gonadotropin releasing hormone 1 Rattus norvegicus 43-73 29970735-0 2018 Evaluation of interleukin-18 in children with steroid-sensitive nephrotic syndrome before and after using levamisole. Steroids 46-53 interleukin 18 Homo sapiens 14-28 11744089-1 2001 The effects of ovarian steroid hormones on gonadotropin-releasing hormone (GnRH) neurons have been studied for many years. Steroids 23-39 gonadotropin releasing hormone 1 Rattus norvegicus 75-79 29970735-7 2018 We found that IL-18 level showed a significant elevation after three months of levamisole therapy compared to its level before initiation of levamisole therapy, with no relapses in these three months, no reported side effect, and significant reduction of cumulative dose of steroids. Steroids 274-282 interleukin 18 Homo sapiens 14-19 11744089-4 2001 Thus, effects of ovarian steroids on GnRH neurons and the NMDAR, and their interactions, are under intense investigation. Steroids 25-33 gonadotropin releasing hormone 1 Rattus norvegicus 37-41 11744089-6 2001 Stimulatory effects of ovarian steroids on GnRH gene expression occur during the preovulatory LH surge in young adult rats, and this is abolished in middle-aged rats that have an attenuated LH surge. Steroids 31-39 gonadotropin releasing hormone 1 Rattus norvegicus 43-47 29631750-0 2018 Steroid Withdrawal Using Everolimus in ABO-Incompatible Kidney Transplant Recipients With Post-Transplant Diabetes Mellitus. Steroids 0-7 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 39-42 11691797-3 2001 Like other kallikreins, the KLK9 gene was found to be regulated by steroid hormones in cancer cell lines. Steroids 67-83 kallikrein related peptidase 9 Homo sapiens 28-32 11691797-11 2001 Our results indicate that KLK9 is under steroid hormone regulation in ovarian and breast cancer cell lines. Steroids 40-55 kallikrein related peptidase 9 Homo sapiens 26-30 11672453-3 2001 Among these isoenzymes, 17 beta HSD type 2 (17 beta HSD2) catalyses the conversion of testosterone into androstenedione and/or oestradiol into oestrone in various tissues, and it has thus been suggested to be involved in the biological inactivation of these sex steroids. Steroids 262-270 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 44-56 29408762-6 2018 Several congeners of lower chlorinated OH-PCBs relevant to airborne PCB exposures were potent inhibitors of SULT1E1 and SULT2A1 and thus have the potential to disrupt regulation of intracellular concentrations of the receptor-active steroid substrates for these enzymes. Steroids 233-240 sulfotransferase family 2A member 1 Homo sapiens 120-127 29334627-1 2018 Neuroactive steroids, including testosterone, dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) might play an important role in the pathophysiology of schizophrenia. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 93-99 11672453-10 2001 17 beta HSD2 immunoreactivity was localized almost exclusively to the absorptive epithelium, which may be involved in the inactivation of excessive endogenous and exogenous active sex steroids. Steroids 184-192 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 8-12 28939401-0 2018 Inefficient UGT-conjugation of adrenal 11beta-hydroxyandrostenedione metabolites highlights C11-oxy C19 steroids as the predominant androgens in prostate cancer. Steroids 104-112 aldo-keto reductase family 1 member C4 Homo sapiens 92-103 11780998-2 2001 The regulation of plasma levels of GH and IGF-I by ovarian steroids is well known, however, their effect on local GH and IGF-I is still unclear. Steroids 59-67 insulin-like growth factor 1 Rattus norvegicus 42-47 28939401-4 2018 The C11-oxy C19 steroids were the predominant steroids with the production of 11KT and 11KDHT in prostate cell models identifying 11beta-hydroxysteroid dehydrogenase type 2 activity. Steroids 16-24 aldo-keto reductase family 1 member C4 Homo sapiens 4-15 28939401-4 2018 The C11-oxy C19 steroids were the predominant steroids with the production of 11KT and 11KDHT in prostate cell models identifying 11beta-hydroxysteroid dehydrogenase type 2 activity. Steroids 46-54 aldo-keto reductase family 1 member C4 Homo sapiens 4-15 28939401-6 2018 In PCa tissue, inactive C11-oxy C19 steroids ranged from 27 to 30 ng/g, whereas inactive C19 steroids were below 1 ng/g. Steroids 36-44 aldo-keto reductase family 1 member C4 Homo sapiens 24-35 28939401-7 2018 Steroid glucuronidation was impeded: in VCaP cells, the C11-oxy C19 steroids were unconjugated and the C19 steroids fully conjugated; in C4-2B cells, all steroids were unconjugated, except for DHT of which 50% was conjugated; in LNCaP cells only androsterone, 11KT and 11beta-hydroxyandrosterone were unconjugated. Steroids 0-7 aldo-keto reductase family 1 member C4 Homo sapiens 56-67 28939401-7 2018 Steroid glucuronidation was impeded: in VCaP cells, the C11-oxy C19 steroids were unconjugated and the C19 steroids fully conjugated; in C4-2B cells, all steroids were unconjugated, except for DHT of which 50% was conjugated; in LNCaP cells only androsterone, 11KT and 11beta-hydroxyandrosterone were unconjugated. Steroids 68-76 aldo-keto reductase family 1 member C4 Homo sapiens 56-67 28939401-9 2018 Even though plasma and tissue sample numbers were limited, this study serves to demonstrate the abundance of C11-oxy C19 steroids, with notable differences in their metabolism, dictated by steroidogenic enzymes and hampered conjugation, affecting active androgen levels. Steroids 121-129 aldo-keto reductase family 1 member C4 Homo sapiens 109-120 28939401-11 2018 The C11-oxy C19 steroids are involved in PCa, with impeded glucuronidation in PCa ascribing a dominant role to these steroids in disease progression. Steroids 16-24 aldo-keto reductase family 1 member C4 Homo sapiens 4-15 11780998-3 2001 In this study, we investigated the effect of ovariectomy and ovarian steroid treatment on the femur GH and IGF-I levels as well as on bone density in the rat. Steroids 69-76 insulin-like growth factor 1 Rattus norvegicus 107-112 11780998-10 2001 Our results demonstrate that ovariectomy and ovarian steroids modulate the levels of GH and IGF-I in the bone of aged OVX rats. Steroids 53-61 insulin-like growth factor 1 Rattus norvegicus 92-97 11566716-5 2001 We hypothesized that FasL expression in human endometrium is cycle-dependent and that sex steroid hormones regulate FasL expression. Steroids 90-106 Fas ligand Homo sapiens 116-120 29293939-12 2018 Supplemental AMH treatment in the culture media promoted preantral follicle growth to the small antral stage in vitro with increased steroid hormone and paracrine factor production, as well as oocyte maturation. Steroids 133-148 anti-Mullerian hormone Macaca mulatta 13-16 28667781-2 2018 Studies of its responses to drug and endogenous ligands have shown TSPO to be involved either directly or indirectly in numerous biological functions, including mitochondrial cholesterol transport and steroid hormone biosynthesis, porphyrin transport and heme synthesis, apoptosis, cell proliferation, and anion transport. Steroids 201-216 translocator protein Homo sapiens 67-71 11566716-7 2001 We then investigated the in vitro regulation of FasL expression by ovarian steroid hormones. Steroids 75-91 Fas ligand Homo sapiens 48-52 11567989-0 2001 Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. Steroids 13-20 basigin (Ok blood group) Homo sapiens 74-79 29351807-1 2018 OBJECTIVE: The primary aim of this study was to investigate the association between the vitamin D receptor polymorphisms rs2228570 (Fok1) and rs731236 (TaqI) and LH and FSH levels in relation to anabolic androgenic steroid (AAS) use. Steroids 215-222 vitamin D receptor Homo sapiens 88-106 11567989-0 2001 Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL. Steroids 13-20 Cbl proto-oncogene Homo sapiens 104-107 11677765-1 2001 OBJECTIVE: To investigate the expression of glucocorticoid receptor (GR) and heat shock protein 90 (HSP90) mRNA in peripheral blood mononuclear cells (PBMCs) from steroid-sensitive (SS), steroid-dependent (SD) and steroid-resistant (SR) asthmatics patients, and to evaluate the role of GR and HSP90 in the pathogenesis of SR. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the expressions of GR and HSP90 mRNA in PBMC stimulated with IL-2 and/or IL-4 from 10 normal volunteers, 10 SS, 5 SD and 6 SR patients. Steroids 163-170 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-98 28722800-4 2018 To address this issue, we evaluated the association between the lncRNA GAS5 and the efficacy of steroids, in terms of inhibition of proliferation, in two cell lines derived from colon and ovarian cancers, to confirm the sensitivity and specificity of these lncRNAs. Steroids 96-104 growth arrest specific 5 Homo sapiens 71-75 11677765-1 2001 OBJECTIVE: To investigate the expression of glucocorticoid receptor (GR) and heat shock protein 90 (HSP90) mRNA in peripheral blood mononuclear cells (PBMCs) from steroid-sensitive (SS), steroid-dependent (SD) and steroid-resistant (SR) asthmatics patients, and to evaluate the role of GR and HSP90 in the pathogenesis of SR. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the expressions of GR and HSP90 mRNA in PBMC stimulated with IL-2 and/or IL-4 from 10 normal volunteers, 10 SS, 5 SD and 6 SR patients. Steroids 163-170 heat shock protein 90 alpha family class A member 1 Homo sapiens 100-105 28722800-8 2018 Furthermore, for the first time, we measured GAS5 levels in 19 paediatric IBD patients at diagnosis and after the first cycle of GCs, and we demonstrated an up-regulation of the lncRNA in patients with unfavourable steroid response. Steroids 215-222 growth arrest specific 5 Homo sapiens 45-49 28554311-15 2018 Dimethyl tryptamine (DMT) and neuroactive steroids are endogenous ligands that activate Sig-1R. Steroids 42-50 sigma non-opioid intracellular receptor 1 Homo sapiens 88-94 11579312-0 2001 Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Steroids 43-51 T-lymphocyte activation antigen CD80 Macaca fascicularis 97-101 11596109-8 2001 The TCR/CD3-mediated hyper [Ca(2+)](i) response in 100 nM Dex-treated cells was readily reversible by short-term culture in steroid-free medium. Steroids 124-131 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 4-7 11404358-3 2001 Hop binds independently to hsp70 and hsp90 to form an hsp90.Hop.hsp70 complex that acts as a machinery to open up the GR steroid binding site. Steroids 121-128 homeodomain-only protein Oryctolagus cuniculus 0-3 29087473-12 2018 Our findings demonstrate that 11beta-HSD1 inhibition can limit the cutaneous effects of GC excess, which may improve the safety profile of systemic steroids and the prognosis of chronic wounds. Steroids 148-156 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 30-41 11404358-3 2001 Hop binds independently to hsp70 and hsp90 to form an hsp90.Hop.hsp70 complex that acts as a machinery to open up the GR steroid binding site. Steroids 121-128 homeodomain-only protein Oryctolagus cuniculus 60-63 29027717-6 2018 SF1 acts in a dose-dependent manner and regulates a cascade of genes involved in the sex determination and steroidogenesis, but in most cases reported so far, still lead to a sufficient adrenal steroidogenesis and function, just like in our cases, in which heterozygous mutations are associated to 46,XY DSD with intact adrenal steroid biosynthesis. Steroids 107-114 splicing factor 1 Homo sapiens 0-3 11377395-3 2001 Here by using neuroleptic agents haloperidol, pimozide, and fluspirilene, all of which can induce TdP, and a steroid hormone-sensitive system Xenopus oocytes for HERG channels expression we show that testosterone is able to reduce HERG-blocking potency of neuroleptics. Steroids 109-124 potassium voltage-gated channel subfamily H member 2 Homo sapiens 162-166 11377395-3 2001 Here by using neuroleptic agents haloperidol, pimozide, and fluspirilene, all of which can induce TdP, and a steroid hormone-sensitive system Xenopus oocytes for HERG channels expression we show that testosterone is able to reduce HERG-blocking potency of neuroleptics. Steroids 109-124 potassium voltage-gated channel subfamily H member 2 Homo sapiens 231-235 28887792-6 2018 As steroid treatment was begun, she developed significant hepatocellular dysfunction with ALT 2,222 U/L, AST 630 U/L, prolonged INR, and elevated ammonia (213 mumol/L). Steroids 3-10 glutamic--pyruvic transaminase 2 Homo sapiens 90-95 11474147-13 2001 Maternal diabetes and the use of steroids had small but significant effects on the leptin/weight ratio. Steroids 33-41 leptin Homo sapiens 83-89 11415851-1 2001 OBJECTIVE: To investigate the levels and diurnal rhythm of serum leptin in healthy children, and to investigate the association between leptin levels and sex steroids. Steroids 158-166 leptin Homo sapiens 136-142 29256503-0 2018 Synthetic nat- or ent-steroids in as few as five chemical steps from epichlorohydrin. Steroids 22-30 bromodomain containing 2 Homo sapiens 10-13 11415851-11 2001 The changes in leptin levels during puberty follow a gender-specific pattern, probably due to an influence of sex steroids on leptin production. Steroids 114-122 leptin Homo sapiens 15-21 11415851-11 2001 The changes in leptin levels during puberty follow a gender-specific pattern, probably due to an influence of sex steroids on leptin production. Steroids 114-122 leptin Homo sapiens 126-132 29778558-4 2018 We present the case of a young patient at high immunological risk, with atypical haemolytic uraemic syndrome due to factor H mutation, who underwent a successful kidney transplantation with eculizumab, thymoglobulin, belatacept, mycophenolate and steroids, to date preserving excellent graft function without disease recurrence. Steroids 247-255 complement factor H Homo sapiens 116-124 11506246-0 2001 Prospective randomized controlled multicenter trial on steroids plus ramipril in proteinuric IgA nephropathy. Steroids 55-63 immunoglobulin heavy variable 4-38-2-like Homo sapiens 93-96 29207898-6 2018 Haplotype analysis showed AAG and GGA haplotypes that contain NR3C1 rs10052957, rs258751 and rs6196 were associated with steroid resistance. Steroids 121-128 N-methylpurine DNA glycosylase Homo sapiens 26-29 11506246-1 2001 Recent studies have shown that steroids improve renal survival and reduce proteinuria in IgA nephropathy (IgAN) patients with moderate urinary protein excretion and normal renal function. Steroids 31-39 immunoglobulin heavy variable 4-38-2-like Homo sapiens 89-92 11319220-1 2001 The small nuclear C(3)HC(4) finger protein (SNURF), RNF4, acts as transcriptional coactivator for both steroid-dependent and -independent promoters such as those driven by androgen response elements and GC boxes, respectively. Steroids 103-110 SNRPN upstream open reading frame Homo sapiens 4-42 29042257-9 2017 HRLC-MS and GC-MS helped identify the presence of gymnemic acid (GA), triterpenoids and steroids in EL which could be the reason for PK interaction of CYP1A2 and CYP2C9. Steroids 88-96 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 151-157 29311967-1 2017 Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Steroids 209-216 relaxin family peptide receptor 2 Bos taurus 57-62 11319220-1 2001 The small nuclear C(3)HC(4) finger protein (SNURF), RNF4, acts as transcriptional coactivator for both steroid-dependent and -independent promoters such as those driven by androgen response elements and GC boxes, respectively. Steroids 103-110 SNRPN upstream open reading frame Homo sapiens 44-49 11319220-1 2001 The small nuclear C(3)HC(4) finger protein (SNURF), RNF4, acts as transcriptional coactivator for both steroid-dependent and -independent promoters such as those driven by androgen response elements and GC boxes, respectively. Steroids 103-110 ring finger protein 4 Homo sapiens 52-56 29445436-0 2017 Steroid Responsive Encephalopathy Associated with Autoantibodies to Thyroperoxidase (STREAT), Presenting with Acute Stroke in a Young Female Patient. Steroids 0-7 thyroid peroxidase Homo sapiens 68-83 11803001-0 2001 [Glucocorticoid receptor and HSP 90 mRNA expression in peripheral blood mononuclear cell from steroid resistant asthmatics]. Steroids 94-101 heat shock protein 90 alpha family class A member 1 Homo sapiens 29-35 11803001-1 2001 OBJECTIVE: To investigate the expression of glucocorticoid receptor (GR) and HSP 90 mRNA in peripheral blood mononuclear cells (PBMC) from steroid-sensitive asthma (SS), steroid-dependant asthma (SD) and steroid-resistant asthma (SR) and assess the role of GR and HSP 90 in the pathogenesis of SR. METHODS: With reverse transcription-polymerase chain reaction (RT-PCR), expression of GR and HSP 90 mRNA were detected in PBMC without or with IL-2 and (or) IL-4 stimulation from 10 normal volunteers, 10 SS, 5 SD and 6 SR patients. Steroids 139-146 heat shock protein 90 alpha family class A member 1 Homo sapiens 77-83 11396977-3 2001 The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR. Steroids 163-170 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 29-32 11396977-3 2001 The soluble cytosolic His(6)-hAR demonstrated similar association and dissociation half-times for mibolerone, similar binding affinity for mibolerone, and similar steroid specificity as bona fide AR. Steroids 163-170 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 30-32 11376858-6 2001 Other steroids including testosterone, dexamethasone, and estradiol are ineffective when added to the culture medium at 10(-6) M for 1 h. The induction of Krox-20 mRNA was also observed with the selective progesterone agonist Organon 2058 and was abolished by treating the MSC80 Schwann cells with the progesterone antagonist RU486, indicating that progesterone induces Krox-20 mRNA expression by binding to its intracellular receptor. Steroids 6-14 early growth response 2 Mus musculus 155-162 15775557-3 2001 The elucidation at the molecular levels such as decrease of Cbfa1 and TGF-beta type I receptor expression by steroid treatment recently advances. Steroids 109-116 transforming growth factor beta receptor 1 Homo sapiens 70-94 11306716-5 2001 The docking of synthetic compounds bearing C-11beta hydrophobic substituents within the ligand binding pocket of hAR demonstrated that precise positions of the steroid, such as C-11 and C-17, are in close contact with some residues on the receptor, C-11 with Gly 708 and C-17 with Asn705 and Thr877. Steroids 160-167 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 113-116 11331666-2 2001 In this study, we focused on retinoic acid receptors (RAR and RXR) which are ligand-dependent transcription factors belonging to the large family of steroid hormones and are expected to affect to cell growth and differentiation in the endometrium. Steroids 149-165 retinoic acid receptor alpha Homo sapiens 54-57 11259263-1 2001 A hallmark of reproductive aging in rats is a delay in the initiation and peak, and a decrease in the amplitude, of both proestrous and steroid-induced surges of LH and a decrease in the number of GnRH neurons that express Fos during the surge. Steroids 136-143 gonadotropin releasing hormone 1 Rattus norvegicus 197-201 11262243-5 2001 The steroid-regulated BR-C, E74A and E93 genes are required for salivary gland cell death. Steroids 4-11 brc Drosophila melanogaster 22-26 11262243-5 2001 The steroid-regulated BR-C, E74A and E93 genes are required for salivary gland cell death. Steroids 4-11 Ecdysone-induced protein 74EF Drosophila melanogaster 28-32 11288760-13 2001 We advance the hypothesis that the elevated local concentration of steroid hormones that occur in adenomas down-regulates 11beta-HSD2 activity, thereby contributing to their abnormal steroidogenic function. Steroids 67-83 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 122-133 11258198-3 2001 We focus first on constitutional ("germline") single nucleotide polymorphism (SNPs) at the steroid 5 alpha-reductase (SRD5A2) locus, which encodes the human prostatic (or Type II) steroid 5 alpha-reductase enzyme. Steroids 91-98 steroid 5 alpha-reductase 2 Homo sapiens 118-124 11374809-1 2001 The Steroidogenic Acute Regulatory (StAR) protein is assumed to enhance the rate-limiting step of the steroid biosynthesis. Steroids 102-109 steroidogenic acute regulatory protein Mus musculus 4-34 11374809-1 2001 The Steroidogenic Acute Regulatory (StAR) protein is assumed to enhance the rate-limiting step of the steroid biosynthesis. Steroids 102-109 steroidogenic acute regulatory protein Mus musculus 36-40 11824513-11 2001 Thus, accumulating evidence suggests that leptin can regulate gonadotropin levels, and its secretion may, in turn, be influenced by GnRH or gonadal steroids but appears to be independent of LH control. Steroids 148-156 leptin Homo sapiens 42-48 11785088-5 2001 The presence of PSA in these female tissues seems to be closely associated with steroid hormone regulation, especially androgens and progestins. Steroids 80-95 kallikrein related peptidase 3 Homo sapiens 16-19 11785088-8 2001 The data presented suggest that PSA can no longer be regarded as a specific prostatic marker, but as a protein that could be produced by cells bearing steroid hormone receptors under conditions of steroid hormone stimulation. Steroids 151-166 kallikrein related peptidase 3 Homo sapiens 32-35 11087816-7 2000 The present results indicate that steroid-producing neurons of the frog hypothalamus express the GABA(A) receptor alpha(3) and beta(2)/beta(3) subunits. Steroids 34-41 gamma-aminobutyric acid type A receptor subunit alpha3 Homo sapiens 97-122 11216651-4 2000 However, it has not been clearly understood whether steroids may act directly at the pituitary or indirectly via modulation of hypothalamic GnRH release. Steroids 52-60 gonadotropin releasing hormone 1 Rattus norvegicus 140-144 11101696-7 2000 The expression of alternatively spliced mRNAs for SC35 was differently regulated both during early pregnancy and by steroid hormones. Steroids 116-132 serine and arginine-rich splicing factor 2 Mus musculus 50-54 11073827-0 2000 Defective interleukin-1 receptor antagonist production is associated with resistance of acute liver graft rejection to steroid therapy. Steroids 119-126 interleukin 1 alpha Homo sapiens 10-23 11073827-2 2000 As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra. Steroids 50-57 interleukin 1 alpha Homo sapiens 3-16 11073827-2 2000 As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra. Steroids 50-57 interleukin 1 alpha Homo sapiens 18-22 11073827-2 2000 As interleukin-1 (IL-1) is an important target of steroid therapy, we examined the possible involvement of reduced sensitivity of IL-1 production to steroids or defective production of its antagonist, IL-1Ra. Steroids 149-157 interleukin 1 alpha Homo sapiens 130-134 11073827-6 2000 IL-1 production and its inhibition by steroids were similar in steroid-responsive and steroid-resistant rejection. Steroids 38-46 interleukin 1 alpha Homo sapiens 0-4 11126340-0 2000 Interactions between sex steroid hormones and leptin in women. Steroids 25-41 leptin Homo sapiens 46-52 11154152-0 2000 Cord blood and postnatal serum leptin and its relationship to steroid use and growth in sick preterm infants. Steroids 62-69 leptin Homo sapiens 31-37 11154152-5 2000 Cord blood leptin was greater in infants whose mothers received antenatal steroids (1.98 +/- 1.05 ng/ml vs 0.94 +/- 0.39 ng/ml, p=0.004). Steroids 74-82 leptin Homo sapiens 11-17 11024552-2 2000 Here, we report that glucocorticoids have two different effects on the vulnerability of human antigen-specific T cells: (i) steroids induce T cell apoptosis in a CD95-independent, but caspase-dependent manner; (ii) steroids protect T cells from CD95-mediated apoptosis which, however, is also caspase-dependent. Steroids 124-132 Fas cell surface death receptor Homo sapiens 162-166 29180785-1 2017 HSD17B1 is a steroid metabolising enzyme. Steroids 13-20 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 0-7 29157197-6 2017 Transcriptional analysis of the FL2 testis showed the differential expression of genes associated with steroid metabolic processes (Cyp1b1, Cyp19a1, Hsd3b6, and Cyp21a1) and female fecundity (Gdf9), accompanied by 150% elevated serum progesterone levels in the FL2 males. Steroids 103-110 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 132-138 11024552-2 2000 Here, we report that glucocorticoids have two different effects on the vulnerability of human antigen-specific T cells: (i) steroids induce T cell apoptosis in a CD95-independent, but caspase-dependent manner; (ii) steroids protect T cells from CD95-mediated apoptosis which, however, is also caspase-dependent. Steroids 124-132 Fas cell surface death receptor Homo sapiens 245-249 11014241-7 2000 Using decidual cells in primary culture obtained from pseudopregnant rats and a decidua-derived cell line (GG-AD), we show a differential regulation of ERalpha and ERbeta by PRL and ovarian steroid hormones. Steroids 190-197 estrogen receptor 1 Rattus norvegicus 152-159 11014241-7 2000 Using decidual cells in primary culture obtained from pseudopregnant rats and a decidua-derived cell line (GG-AD), we show a differential regulation of ERalpha and ERbeta by PRL and ovarian steroid hormones. Steroids 190-197 estrogen receptor 2 Rattus norvegicus 164-170 28863887-1 2017 The human 3beta-hydroxysteroid dehydrogenase/isomerase (HSD3B) enzymes catalyze the conversion of 3beta-hydroxy Delta5-6 steroids into 3-keto Delta4-5 steroids, which is required for the synthesis of the mature steroid hormones secreted by the adrenal and gonads. Steroids 211-227 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 56-61 11014241-12 2000 In summary, the results of this investigation have revealed that ERbeta is expressed in addition to ERalpha in the rat decidua, and that the expression of both ERs are cell specific and differentially regulated by PRL and steroids. Steroids 222-230 estrogen receptor 2 Rattus norvegicus 65-71 11005250-2 2000 In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, specially in the rat, monkey and human. Steroids 51-59 estrogen receptor 1 Rattus norvegicus 211-218 28137513-7 2017 Thus, the uniform binding energy from the B-ring of steroids with the active site of 3alpha-HSD/CR equally contributes 2.1 kcal/mol to stabilize both the transition state and ground state of the ternary complex, leading to the similarity in kcat for 2-decalol and cyclohexanol. Steroids 52-60 aldo-keto reductase family 1 member C4 Homo sapiens 85-95 11061520-2 2000 To obtain a better understanding of the regulation of local steroid biosynthesis and metabolism in human tissues, we have established a dual steroidogenic activity of the 17betaHSD2 enzyme after transfection of human 17betaHSD2-transfected human embryonic kidney (293) cells. Steroids 60-67 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 171-181 28708534-2 2017 Due to the relationship between sex steroid hormones, oxytocin receptor (OTR) expression and cryptorchidism pathogenesis, this study aimed to investigate the mRNA expression and the localization of OTR in relation to sex steroid receptors in the male reproductive tract of both normal and unilateral abdominal cryptorchid dogs using quantitative PCR and immunohistochemistry. Steroids 36-43 oxytocin receptor Canis lupus familiaris 198-201 11061520-2 2000 To obtain a better understanding of the regulation of local steroid biosynthesis and metabolism in human tissues, we have established a dual steroidogenic activity of the 17betaHSD2 enzyme after transfection of human 17betaHSD2-transfected human embryonic kidney (293) cells. Steroids 60-67 hydroxysteroid 17-beta dehydrogenase 2 Homo sapiens 217-227 10984637-1 2000 The effects of gonadal steroids or tamoxifen over the synaptic density of the CA1 region of the hippocampus was investigated in ovariectomized (OVX) rats. Steroids 23-31 carbonic anhydrase 1 Rattus norvegicus 78-81 28911168-0 2017 Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Mediators of Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. Steroids 49-56 LOC105613195 Ovis aries 95-102 11074350-12 2000 The present observations suggest the involvement of cGMP and PKG in control of the production of steroid, nonapeptide hormone, growth factor, cAMP and cAMP-dependent PKA, as well as the induction of apoptosis in porcine ovarian cells. Steroids 97-104 protein kinase cGMP-dependent 1 Homo sapiens 61-64 28467680-1 2017 Targeting the biosynthetic pathway of neuroactive steroids with specific 18 kDa translocator protein (TSPO) ligands may be a viable therapeutic approach for a variety of neurodegenerative and neuropsychiatric diseases. Steroids 50-58 translocator protein Homo sapiens 80-100 28467680-1 2017 Targeting the biosynthetic pathway of neuroactive steroids with specific 18 kDa translocator protein (TSPO) ligands may be a viable therapeutic approach for a variety of neurodegenerative and neuropsychiatric diseases. Steroids 50-58 translocator protein Homo sapiens 102-106 11074357-0 2000 Anabolic steroid and gender-dependent modulation of cytosolic HSP70s in fast- and slow-twitch skeletal muscle. Steroids 9-16 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 62-67 28860760-8 2017 Hsd17b1, Hsd3b1, Hsd3b6, and Hsd3b were involved in steroid and hormone metabolism, whereas Mt3 and Cebpb were associated with apoptosis. Steroids 52-59 hydroxysteroid (17-beta) dehydrogenase 1 Rattus norvegicus 0-7 28860760-8 2017 Hsd17b1, Hsd3b1, Hsd3b6, and Hsd3b were involved in steroid and hormone metabolism, whereas Mt3 and Cebpb were associated with apoptosis. Steroids 52-59 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Rattus norvegicus 17-23 11028555-3 2000 Aromatase is a key enzyme in the sex steroid biosynthesis. Steroids 37-44 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 0-9 28618255-7 2017 The global RANKL/OPG ratio in the spine after 8 months of steroid and dietary treatment was not different from that of the control. Steroids 58-65 TNF superfamily member 11 Homo sapiens 11-16 11043771-4 2000 Steroids and retinoids similarly downregulate c-Myc and induce apoptosis in these B cells and synergize with anti-mu. Steroids 0-8 MYC proto-oncogene, bHLH transcription factor Homo sapiens 46-51 28618255-8 2017 Interestingly, assessment of the osteocyte-specific RANKL/OPG ratio showed that the steroid-induced osteoporosis in its late progressive phase stimulates RANKL expression in osteocytes. Steroids 84-91 TNF superfamily member 11 Homo sapiens 52-57 28618255-8 2017 Interestingly, assessment of the osteocyte-specific RANKL/OPG ratio showed that the steroid-induced osteoporosis in its late progressive phase stimulates RANKL expression in osteocytes. Steroids 84-91 TNF superfamily member 11 Homo sapiens 154-159 10844203-8 2000 The receptor mapping, neuronal tracing and microimplantation studies suggest that the ventromedial nucleus is likely to be a key hypothalamic nucleus in the steroid regulation of GnRH secretion in sheep. Steroids 157-164 Progonadoliberin-1 Ovis aries 179-183 28506883-10 2017 Our findings indicate the involvement of NKA-SRc-Kinase-Ras-Raf-ERK1/2 pathway in the downregulation of NHE3 by cardiotonic steroids in the renal proximal tubule, promoting a reduction of proximal sodium reabsorption and natriuresis. Steroids 124-132 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 45-48 10859269-0 2000 Steroid-dependent up-regulation of adipose leptin secretion in vitro during pregnancy in mice. Steroids 0-7 leptin Mus musculus 43-49 28754914-0 2017 Memory-type ST2+CD4+ T cells participate in the steroid-resistant pathology of eosinophilic pneumonia. Steroids 48-55 interleukin 1 receptor-like 1 Mus musculus 12-15 28754914-8 2017 Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2+CD4+ T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance. Steroids 201-208 interleukin 1 receptor-like 1 Mus musculus 115-118 28754914-8 2017 Thus our study provides novel insight into the pathogenesis of eosinophilic lung disease, showing that memory-type ST2+CD4+ T cells are involved in IL-33-induced eosinophilic inflammation and elicited steroid-resistance. Steroids 201-208 interleukin 33 Mus musculus 148-153 10849206-10 2000 We conclude that the amount of NPY in cell bodies of the ARC-ME is lower in ewes in the nonbreeding season; this could reflect a steroid-independent effect of photoperiod. Steroids 129-136 neuropeptide Y Homo sapiens 31-34 11460687-7 2000 Furthermore, the elevation of CYP1A in response to sewage effluent exposure indicates the presence of additional compounds that may alter xenobiotic and/or steroid biotransformation in fish. Steroids 156-163 cytochrome P450 1A1 Fundulus heteroclitus 30-35 28192162-0 2017 Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging. Steroids 78-94 receptor for activated C kinase 1 Homo sapiens 30-35 10764743-0 2000 Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. Steroids 167-174 heat shock protein 90 alpha family class A member 1 Homo sapiens 47-52 28442392-1 2017 The translocator protein (TSPO) is an outer mitochondrial membrane protein involved in the transport of cholesterol into the mitochondria, which is the first step for the synthesis of steroid hormones, as well as in the regulation of mitochondrial permeability transition pore opening and apoptosis. Steroids 184-200 translocator protein Homo sapiens 4-24 28442392-1 2017 The translocator protein (TSPO) is an outer mitochondrial membrane protein involved in the transport of cholesterol into the mitochondria, which is the first step for the synthesis of steroid hormones, as well as in the regulation of mitochondrial permeability transition pore opening and apoptosis. Steroids 184-200 translocator protein Homo sapiens 26-30 10764743-0 2000 Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. Steroids 167-174 heat shock protein 90 alpha family class A member 1 Homo sapiens 143-148 10764743-2 2000 Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and three proteins, Hop, hsp40, p23, act as co-chaperones that enhance activation and assembly (Morishima, Y., Kanelakis, K. C., Silverstein, A.M., Dittmar, K. D., Estrada, L., and Pratt, W. B. Steroids 66-73 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-19 28426945-3 2017 The serotonin 4 receptor (5-HT4R) indexes central serotonergic tonus, which may be related to endogenous sex-steroid levels in the mentally healthy state even though this remains elusive. Steroids 109-116 5-hydroxytryptamine receptor 4 Homo sapiens 26-32 10764743-8 2000 hsp90 is required for opening of the steroid binding pocket and is converted to its ATP-dependent conformation during this second step. Steroids 37-44 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 10764743-10 2000 This conversion initiates the opening of the hydrophobic steroid binding pocket such that it can now accept the hydrophobic binding form of hsp90, which in turn must be converted to its ATP-dependent conformation for the pocket to be accessible by steroid. Steroids 57-64 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 10764743-10 2000 This conversion initiates the opening of the hydrophobic steroid binding pocket such that it can now accept the hydrophobic binding form of hsp90, which in turn must be converted to its ATP-dependent conformation for the pocket to be accessible by steroid. Steroids 248-255 heat shock protein 90 alpha family class A member 1 Homo sapiens 140-145 10842238-5 2000 This could involve changes in the expression and activity of steroid receptors and steroid-metabolizing enzymes, such as the estrogen-synthesizing enzyme aromatase (AROM). Steroids 61-68 aromatase Serinus canaria 154-163 28330858-3 2017 Several studies reported that pregnancy or lactation influences liver cytochrome P450 (P450) expression and its activity, affecting the biosynthesis of steroids and xenobiotics through growth hormone or sex hormones; however, the role of prolactin as the regulator of liver P450 expression has not been elucidated so far. Steroids 152-160 prolactin Mus musculus 238-247 28330858-10 2017 We conjecture that higher concentration of prolactin would alter steroid and xenobiotic metabolisms by modulating hepatic P450 gene expressions during pregnancy and lactation. Steroids 65-72 prolactin Mus musculus 43-52 28131616-6 2017 After the discovery of the indispensable role of kisspeptin in the development of human reproductive functions, our understanding of the neuroendocrine regulation of the HPG axis was revolutionized, and it is now recognized that kisspeptin acts upstream of GnRH and is responsible for sex steroid feedback mechanisms. Steroids 289-296 KiSS-1 metastasis-suppressor Mus musculus 229-239 27833556-1 2016 Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. Steroids 16-24 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 113-118 10873033-12 2000 CONCLUSIONS: This report provides the first description of maternal steroid administration effecting a marked increase in fetal IGF-1 mRNA expression and IGF-1 protein levels in an in vivo rabbit model of IUGR. Steroids 68-75 insulin-like growth factor I Oryctolagus cuniculus 128-133 27833556-6 2016 Furthermore, rescue of postsynaptic GABAA receptors in Purkinje cells normalized the effect of the steroid. Steroids 99-106 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 36-41 28342744-3 2017 Hexacyclic steroids bearing a benzyl group at C-22, derived from 16-dehydropregnenolone and 16-dehydroprogesterone, show considerable cytotoxicity against EL4 (murine T-lymphoma) in contrast with the corresponding C-22-unsubstituted derivatives showing low cytotoxicity. Steroids 11-19 Sp7 transcription factor 7 Mus musculus 214-218 28366698-0 2017 Steroid free immunosuppression is associated with enhanced Th1 transcripts in kidney transplantation. Steroids 0-7 negative elongation factor complex member C/D Homo sapiens 59-62 10873033-12 2000 CONCLUSIONS: This report provides the first description of maternal steroid administration effecting a marked increase in fetal IGF-1 mRNA expression and IGF-1 protein levels in an in vivo rabbit model of IUGR. Steroids 68-75 insulin-like growth factor I Oryctolagus cuniculus 154-159 10831247-9 2000 Feedback control of corticotropin-releasing hormone (CRH) secretion is exerted by free steroids diffusing into the brain, but substances such as cytokines and angiotensin II act on CVO to produce increases in CRH secretion. Steroids 87-95 corticotropin releasing hormone Homo sapiens 20-51 28529456-8 2017 Furthermore, the bone marrow fat formation, as well as the expression of Wnt3a and PPARgamma, was effectively regulated by HGE in the steroid-induced ONFH rats. Steroids 134-141 peroxisome proliferator-activated receptor gamma Rattus norvegicus 83-92 27637086-0 2016 A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head. Steroids 78-85 matrix metallopeptidase 9 Homo sapiens 36-40 27637086-2 2016 Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Steroids 119-126 M-phase phosphoprotein 9 Homo sapiens 101-105 27637086-4 2016 The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Steroids 66-73 matrix metallopeptidase 9 Homo sapiens 21-25 27637086-5 2016 Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Steroids 95-102 matrix metallopeptidase 9 Homo sapiens 24-28 27637086-6 2016 Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population. Steroids 210-217 matrix metallopeptidase 9 Homo sapiens 154-158 27542238-0 2016 A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1. Steroids 2-9 sirtuin 1 Homo sapiens 181-187 28213303-6 2017 Gene expression and plasma steroid level analyses demonstrated the suppressed mRNA levels of the key genes (such as gnrh3, fshbeta and lhbeta in brain and dmrt1, sf1, cyp17a1 and cyp11b2 in testis) in HPG axis and decreased 11-ketotestosterone (11-KT) levels in plasma. Steroids 27-34 follicle stimulating hormone subunit beta Danio rerio 123-130 27546572-10 2016 Because both PTTH and systemic insulin signaling are themselves under circadian control, we conclude that de-synchronization of a local endocrine clock with external circadian cues is the primary cause for steroid production to fail. Steroids 206-213 Insulin-like receptor Drosophila melanogaster 31-38 10831247-9 2000 Feedback control of corticotropin-releasing hormone (CRH) secretion is exerted by free steroids diffusing into the brain, but substances such as cytokines and angiotensin II act on CVO to produce increases in CRH secretion. Steroids 87-95 corticotropin releasing hormone Homo sapiens 53-56 10868704-9 2000 We conclude that the effect of topical steroids on reducing eosinophil infiltration in nasal polyps may be due in part to downregulation, among other cytokines, of epithelial GM-CSF production which prolongs eosinophil viability. Steroids 39-47 colony stimulating factor 2 Homo sapiens 175-181 27657907-0 2016 Bromodomain and Extra Terminal (BET) Inhibitor Suppresses Macrophage-Driven Steroid-Resistant Exacerbations of Airway Hyper-Responsiveness and Inflammation. Steroids 76-83 delta/notch-like EGF repeat containing Mus musculus 32-35 27657907-6 2016 We hypothesised that BET proteins may be involved in the regulation of AHR and airway inflammation in our steroid-resistant exacerbation models. Steroids 106-113 delta/notch-like EGF repeat containing Mus musculus 21-24 27657907-7 2016 METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of a BET inhibitor (I-BET-762) on the development of steroid-resistant AHR and airway inflammation in two mouse models. Steroids 113-120 delta/notch-like EGF repeat containing Mus musculus 65-68 27657907-7 2016 METHODOLOGY/PRINCIPAL FINDINGS: We investigated the effects of a BET inhibitor (I-BET-762) on the development of steroid-resistant AHR and airway inflammation in two mouse models. Steroids 113-120 delta/notch-like EGF repeat containing Mus musculus 82-85 26596800-6 2017 Cytochrome P450 18a1 encodes a key enzyme for steroid hormone inactivation and Kruppel homolog 1 is an early juvenile hormone-inducible gene that mediates the repression of metamorphosis. Steroids 46-61 cytochrome P450 18a1 Bombyx mori 0-20 27657907-9 2016 I-BET treatment also suppressed key inflammatory cytokines linked to the development of steroid-resistant inflammation such as monocyte chemoattractant protein 1 (MCP-1), keratinocyte-derived protein chemokine (KC), IFNgamma, and interleukin 27 (IL-27). Steroids 88-95 delta/notch-like EGF repeat containing Mus musculus 2-5 11832064-7 2000 Intralesional injection of steroid could increase c-myc and p53 gene expression of hypertrophic scars in vivo, which induced apoptosis of cells. Steroids 27-34 MYC proto-oncogene, bHLH transcription factor Homo sapiens 50-55 27264458-0 2016 A combination of dexamethasone and anti-IL-17A treatment can alleviate diesel exhaust particle-induced steroid insensitive asthma. Steroids 103-110 interleukin 17A Homo sapiens 40-46 28302174-12 2017 The p38 inhibitor SB203580 could increase the steroid production in HDL3, 22(R)-diol or pregnenolone treated cells. Steroids 46-53 high density lipoprotein (HDL) level 3 Mus musculus 68-72 10770490-8 2000 Consistent with the observed impairment in SF1 function, other SF1-dependent genes, including Cyp11b1 and steroidogenic acute regulatory protein (StAR), were poorly expressed and global steroidogenesis, as evidenced by the metabolism of 22(R)-hydroxycholesterol to steroid products, was impaired. Steroids 106-113 steroidogenic acute regulatory protein Mus musculus 146-150 28272372-3 2017 In this review article, we describe common polymorphisms at three steroidogenic loci (CYP11B2, CYP11B1 and CYP17A1) that alter gene transcription efficiency and levels of key steroids, including aldosterone. Steroids 175-183 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 95-102 27511026-9 2016 Overall our study reveals the existence of a cell-specific negative feedback loop from BRI1-mediated BES1 transcription factor to BRL3 in phloem cells, while contributing to a general understanding of the spatial control of steroid signaling in plant development. Steroids 224-231 BRI1-like 3 Arabidopsis thaliana 130-134 10803476-10 2000 IGF-I/IGFBPs system data were correlated with cognitive impairment and adrenal steroid levels in AD patients. Steroids 79-86 insulin like growth factor binding protein 1 Homo sapiens 6-12 27389590-8 2016 Interestingly, three transcription factors, SREBF2, NR5A1 and PGR, act as central signal modulators of steroid biosynthesis and hormonal interactions during the transition from laying to brooding modes at the molecular level. Steroids 103-110 sterol regulatory element binding transcription factor 2 Gallus gallus 44-50 27389590-8 2016 Interestingly, three transcription factors, SREBF2, NR5A1 and PGR, act as central signal modulators of steroid biosynthesis and hormonal interactions during the transition from laying to brooding modes at the molecular level. Steroids 103-110 progesterone receptor Gallus gallus 62-65 28379592-12 2017 During steroid tapering, there was a slow decline in the levels of both the transaminases and the GGT, and a concomitant increase in the serum albumin. Steroids 7-14 inactive glutathione hydrolase 2 Homo sapiens 98-101 27884727-11 2017 Further, steroid treatment inhibited the hypoxia-induced increase of the miR-375 target genes Bcl-2 and RAD1. Steroids 9-16 microRNA 375 Rattus norvegicus 73-80 27884727-11 2017 Further, steroid treatment inhibited the hypoxia-induced increase of the miR-375 target genes Bcl-2 and RAD1. Steroids 9-16 RAD1 checkpoint DNA exonuclease Rattus norvegicus 104-108 27737514-10 2017 The present study suggests that sustentacular cells and acinar cells of the Bowman"s glands in the rat OM express at least three of the steroid-metabolizing enzymes, that is, P450scc 17beta-HSD-1, and 17beta-HSD-2, and de novo synthesis of estradiol takes place in the OM. Steroids 136-143 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 175-182 27737514-10 2017 The present study suggests that sustentacular cells and acinar cells of the Bowman"s glands in the rat OM express at least three of the steroid-metabolizing enzymes, that is, P450scc 17beta-HSD-1, and 17beta-HSD-2, and de novo synthesis of estradiol takes place in the OM. Steroids 136-143 hydroxysteroid (17-beta) dehydrogenase 1 Rattus norvegicus 183-195 28352346-9 2017 These results suggest that Sal B prevents steroid-induced osteonecrosis of the femoral head via PPARgamma expression in rats. Steroids 42-49 peroxisome proliferator-activated receptor gamma Rattus norvegicus 96-105 27494699-11 2016 Thus, both of these sex steroids can rapidly modulate the odor responsiveness of ORNs through membrane progestin receptors and the estradiol receptor Gpr30. Steroids 24-32 G protein-coupled estrogen receptor 1 Mus musculus 150-155 11253246-2 2000 Although it is indeed produced at an extremely high level by the prostate, PSA is also expressed in many female tissues, especially those regulated by sex steroid hormones. Steroids 155-171 kallikrein related peptidase 3 Homo sapiens 75-78 26682953-1 2016 Dehydroepiandrosterone (DHEA) is an adrenal steroid that circulates in high concentrations in humans in its sulfated form, DHEAS. Steroids 44-51 sulfotransferase family 2A member 1 Homo sapiens 123-128 10792789-6 2000 Immunohistochemically, the tumor expressed the adrenal 4 binding protein and a number of enzymes involved in the synthesis of adrenocortical steroids. Steroids 141-149 nuclear receptor subfamily 5 group A member 1 Homo sapiens 47-72 27462133-2 2016 The present study was attempted to localize EFA6 type D (EFA6D) in mouse adrenocortical cells in situ whose steroid hormone secretion is generally considered not to depend on the vesicle-involved regulatory mechanism. Steroids 108-123 pleckstrin and Sec7 domain containing 3 Mus musculus 57-62 28003376-0 2017 Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. Steroids 86-93 interleukin-1 receptor-associated kinase 4 Mus musculus 10-15 10832596-0 2000 Differential steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in breast cancer cell lines. Steroids 13-28 kallikrein related peptidase 3 Homo sapiens 80-111 27033324-1 2016 The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. Steroids 85-101 solute carrier family 10 member 6 Homo sapiens 4-46 27033324-1 2016 The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. Steroids 85-101 solute carrier family 10 member 6 Homo sapiens 47-51 10832596-1 2000 We have investigated the steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in the breast cancer cell lines BT-474, T-47D, MFM-223, MCF-7, ZR-75-1, MDA-MB-435, and BT-20. Steroids 25-40 kallikrein related peptidase 3 Homo sapiens 92-123 27033324-1 2016 The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. Steroids 85-92 solute carrier family 10 member 6 Homo sapiens 4-46 27033324-1 2016 The sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones and is supposed to play a role in testicular steroid regulation and male fertility. Steroids 85-92 solute carrier family 10 member 6 Homo sapiens 47-51 10647874-3 2000 Acute rejection gave a characteristic and marked increase in blood C3a, C4a and gamma-glutamyl transferase (gammaGT) levels, which rapidly resolved after high dose steroid treatment. Steroids 164-171 complement C4A (Rodgers blood group) Homo sapiens 72-75 27232585-1 2016 The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- and C19-positions has been developed and applied to the total asymmetric synthesis of steroids 19-hydroxysarmentogenin and trewianin aglycone as well as to the assembly of the panogenin core. Steroids 51-59 RNA polymerase III subunit K Homo sapiens 88-91 27232585-1 2016 The expedient and scalable approach to cardiotonic steroids carrying oxygenation at the C11- and C19-positions has been developed and applied to the total asymmetric synthesis of steroids 19-hydroxysarmentogenin and trewianin aglycone as well as to the assembly of the panogenin core. Steroids 179-187 RNA polymerase III subunit K Homo sapiens 88-91 10710742-1 2000 OBJECTIVE: To determine whether elevated follicular steroid levels during gonadotropin stimulation cycles are associated with altered circulating leptin concentrations. Steroids 52-59 leptin Homo sapiens 146-152 27079298-9 2016 Circulating CD4(+) CRTh2(+) T cells, unlike eosinophils, were positively correlated with inhaled steroid dose. Steroids 97-104 prostaglandin D2 receptor 2 Homo sapiens 19-24 11268391-0 2000 Possible function of IL-6 and TNF as intraadrenal factors in the regulation of adrenal steroid secretion. Steroids 87-94 tumor necrosis factor Bos taurus 30-33 27068699-2 2016 Kisspeptin neurons in the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (Arc) of the hypothalamus mediate differential effects, with the Arc regulating negative feedback of sex steroids and the AVPV regulating positive feedback, vital for the preovulatory surge and gated under circadian control. Steroids 196-204 KiSS-1 metastasis-suppressor Mus musculus 0-10 10606935-4 2000 OBJECTIVE: To investigate the expression of STAT6 in the allergen-induced late nasal response and to examine the effect of local steroid treatment on STAT6 expression. Steroids 129-136 signal transducer and activator of transcription 6 Homo sapiens 150-155 27038884-1 2016 AIMS: IL-17A plays a key role in the persistence of airway inflammation, oxidative stress, and reduction of steroid-sensitivity in COPD. Steroids 108-115 interleukin 17A Homo sapiens 6-12 10606935-17 2000 The results support a role for STAT6 and IL-4 in the pathogenesis of late nasal response and show that decreases in STAT6 expression parallel the reduction in IL-4 expression that occurs with topical steroid treatment. Steroids 200-207 signal transducer and activator of transcription 6 Homo sapiens 31-36 10606935-17 2000 The results support a role for STAT6 and IL-4 in the pathogenesis of late nasal response and show that decreases in STAT6 expression parallel the reduction in IL-4 expression that occurs with topical steroid treatment. Steroids 200-207 signal transducer and activator of transcription 6 Homo sapiens 116-121 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Steroids 68-76 C-C motif chemokine ligand 2 Homo sapiens 25-30 27012966-6 2016 Immunosuppression consisted of a standard regime of tacrolimus and low-dose steroids as in ABO compatible/identical LDLT. Steroids 76-84 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 91-94 10963624-6 2000 A number of molecular epidemiologic studies have been conducted to evaluate associations between polymorphic genes involved in steroid hormone metabolism (i.e., CYP17, COMT, CYP1A1, CYP19, GST, and MnSOD) that may account for a proportion of enzymatic variability, and results are discussed in this review. Steroids 127-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 174-180 27109820-0 2016 Increased serum VDBP as a risk predictor for steroid resistance in asthma patients. Steroids 45-52 GC vitamin D binding protein Homo sapiens 16-20 27109820-3 2016 OBJECTIVE: The aim of this study was to evaluate the difference in serum proteomes between steroid-sensitive asthma (SSA) and steroid-resistant asthma (SRA) patients and identify potential biomarkers for the prediction of SR in asthma patients. Steroids 126-133 steroid receptor RNA activator 1 Homo sapiens 152-155 10794519-0 2000 Expression of glucose transporter 4 mRNA in adipose tissue and skeletal muscle of ovariectomized rats treated with sex steroid hormones. Steroids 119-135 solute carrier family 2 member 4 Rattus norvegicus 14-35 27046080-3 2016 Previous biochemical and genetic analysis of the specificity-subunit of Drosophila NURF (Nurf301/Enhancer of Bithorax (E(bx)) has defined NURF as a critical regulator of homeotic, heat-shock and steroid-responsive gene transcription. Steroids 195-202 Enhancer of bithorax Drosophila melanogaster 83-87 27046080-3 2016 Previous biochemical and genetic analysis of the specificity-subunit of Drosophila NURF (Nurf301/Enhancer of Bithorax (E(bx)) has defined NURF as a critical regulator of homeotic, heat-shock and steroid-responsive gene transcription. Steroids 195-202 Enhancer of bithorax Drosophila melanogaster 89-117 27046080-3 2016 Previous biochemical and genetic analysis of the specificity-subunit of Drosophila NURF (Nurf301/Enhancer of Bithorax (E(bx)) has defined NURF as a critical regulator of homeotic, heat-shock and steroid-responsive gene transcription. Steroids 195-202 Enhancer of bithorax Drosophila melanogaster 119-124 27046080-3 2016 Previous biochemical and genetic analysis of the specificity-subunit of Drosophila NURF (Nurf301/Enhancer of Bithorax (E(bx)) has defined NURF as a critical regulator of homeotic, heat-shock and steroid-responsive gene transcription. Steroids 195-202 Enhancer of bithorax Drosophila melanogaster 138-142 10644912-2 2000 A combination of initial endocrine treatment and steroid therapy resulted in normalization of prostate-specific antigen levels followed by a rapid decrease of urinary protein excretion within 4 months. Steroids 49-56 kallikrein related peptidase 3 Homo sapiens 94-119 11036940-7 2000 There is a sexual dimorphism in GHRH receptor expression in the rat pituitary, suggesting regulation by gonadal steroids. Steroids 112-120 growth hormone releasing hormone receptor Rattus norvegicus 32-45 10567384-7 1999 However, at molar ratios approaching stoichiometry with hsp70, BAG-1 produced a concentration-dependent inhibition of GR folding to the steroid-binding form with corresponding inhibition of GR.hsp90 heterocomplex assembly by the minimal five-protein chaperone system. Steroids 136-143 heat shock protein 90 alpha family class A member 1 Homo sapiens 193-198 10630892-2 1999 Metabolism of steroid hormones with anabolic properties was studied in vitro using human recombinant CYP3A4, CYP2C9 and 2B6 enzymes. Steroids 14-30 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 109-123 10630892-5 1999 When the same formats of CYP2C9 were incubated with the anabolic steroids, no 6beta-hydroxyl metabolites were formed. Steroids 65-73 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 25-31 10549972-1 1999 The low density lipoprotein receptor plays an important role in the uptake of maternal plasma lipoproteins for placental steroid metabolism. Steroids 121-128 low density lipoprotein receptor Homo sapiens 4-36 10598896-8 1999 Perioperaitve steroid therapy plays an important role in preventing complications after AVR when the valve replacement is carried out during the active phase of the inflammation, and for patients with non-Takayasu"s aortitis, aortic root replacement should be considered to reduce the tension on the suture line and the native aortic valve annulus. Steroids 14-21 NLR family pyrin domain containing 6 Homo sapiens 88-91 10521447-12 1999 These results demonstrate an intriguing role of AML3/CBFalpha1 in steroid- as well as tissue-specific activation of target genes. Steroids 66-73 runt related transcription factor 2 Mus musculus 48-52 10521447-12 1999 These results demonstrate an intriguing role of AML3/CBFalpha1 in steroid- as well as tissue-specific activation of target genes. Steroids 66-73 runt related transcription factor 2 Mus musculus 53-62 10491646-11 1999 These data indicate that, in addition to expression in epithelial cells and stromal tissue, MMPs are expressed in endometrial vascular cells in a cycle-specific pattern, consistent with regulation by steroid hormones and with specific roles in the vascular remodeling processes occurring in the endometrium during the cycle. Steroids 200-216 matrix metallopeptidase 1 Homo sapiens 92-96 10520130-14 1999 This study also shows that expression of Gal-R1 mRNA in GnRH cells is influenced by the levels of circulating gonadal steroids. Steroids 118-126 galanin receptor 1 Rattus norvegicus 41-47 10520130-14 1999 This study also shows that expression of Gal-R1 mRNA in GnRH cells is influenced by the levels of circulating gonadal steroids. Steroids 118-126 gonadotropin releasing hormone 1 Rattus norvegicus 56-60 10517672-14 1999 These results indicate that members of the NF1 transcription factor family regulate high constitutive expression of the rat 3alpha-HSD/DD gene that is responsible for steroid hormone inactivation. Steroids 167-182 neurofibromin 1 Rattus norvegicus 43-46 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 183-199 steroidogenic acute regulatory protein Mus musculus 4-34 26688086-2 2016 TSPO is found in different species and is expressed at high levels in tissues that synthesize steroids but is also present in other peripheral tissues especially in the heart. Steroids 94-102 translocator protein Homo sapiens 0-4 26812590-1 2016 The androgen receptor (AR) is a widely distributed molecule indicating the spread actions of its ligand steroid, and plays an important role underlying male sexual behavior. Steroids 104-111 androgen receptor Rattus norvegicus 4-21 26812590-1 2016 The androgen receptor (AR) is a widely distributed molecule indicating the spread actions of its ligand steroid, and plays an important role underlying male sexual behavior. Steroids 104-111 androgen receptor Rattus norvegicus 23-25 25155366-1 2016 Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Steroids 146-153 growth differentiation factor 9 Homo sapiens 0-31 25155366-1 2016 Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) act synergistically to regulate granulosa cell proliferation and steroid production in several species. Steroids 146-153 growth differentiation factor 9 Homo sapiens 33-37 26739753-5 2016 Whole-genome expression screening revealed widespread transcriptional changes with Kdm5b depletion, notably the up-regulation of reelin (Reln), the inhibition of steroid biosynthetic pathway component genes and the activation of genes with intracellular transport functions in cultured adult NSCs. Steroids 162-169 lysine (K)-specific demethylase 5B Mus musculus 83-88 26833131-8 2016 Collectively, we suggest that DGCR8-dependent canonical microRNAs are essential for uterine development and physiological processes such as proper immune modulation, reproductive cycle, and steroid hormone responsiveness in mice. Steroids 190-205 DGCR8, microprocessor complex subunit Mus musculus 30-35 28139699-1 2017 The C2H2-type zinc finger protein ZNF764 acts as an enhancer for several steroid hormone receptors, and haploinsufficiency of this gene may be responsible for tissue resistance to multiple steroid hormones including glucocorticoids observed in a patient with 16p11.2 microdeletion. Steroids 189-205 zinc finger protein 764 Homo sapiens 34-40 27814026-0 2017 GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer. Steroids 47-63 G protein-coupled estrogen receptor 1 Homo sapiens 0-4 27814026-0 2017 GPER (GPR30): A Nongenomic Receptor (GPCR) for Steroid Hormones with Implications for Cardiovascular Disease and Cancer. Steroids 47-63 G protein-coupled estrogen receptor 1 Homo sapiens 6-11 27814026-1 2017 Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways. Steroids 30-38 G protein-coupled estrogen receptor 1 Homo sapiens 237-264 27814026-1 2017 Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways. Steroids 30-38 G protein-coupled estrogen receptor 1 Homo sapiens 266-270 27814026-1 2017 Although the rapid effects of steroids, such as estrogen and aldosterone, were postulated originally to be nongenomic, it is now appreciated that activation of such signaling pathways via a steroid-acting G protein-coupled receptor, the G protein estrogen receptor (GPER), has important transcription-dependent outcomes in the regulation of cell growth and programmed cell death secondary to GPER-regulated second-messenger pathways. Steroids 30-38 G protein-coupled estrogen receptor 1 Homo sapiens 392-396 27870419-4 2017 With the support of relevant studies, it has been suggested that sex hormones or steroids can modulate the activities of BDNF, which may account for its functional discrepancy in different sexes. Steroids 81-89 brain derived neurotrophic factor Homo sapiens 121-125 27870419-5 2017 Indeed, the cross-talk between BDNF and sex steroids has been detected for decades, and some sex steroids, such as estrogen, have a positive regulatory effect on BDNF expression and signaling. Steroids 97-105 brain derived neurotrophic factor Homo sapiens 162-166 27355979-8 2017 Between period 1 and 2, there were differences in systemic and inhaled steroid use and mucolytic use. Steroids 71-78 period circadian regulator 2 Homo sapiens 8-22 28598825-3 2017 Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Steroids 134-141 RAR related orphan receptor A Homo sapiens 40-44 27634205-7 2017 TCF3-ZNF384-positive patients revealed a significantly poorer steroid response and a higher frequency of relapse, and the additional activating mutations in RAS signaling pathway genes were detected by whole exome analysis in some of the cases. Steroids 62-69 zinc finger protein 384 Homo sapiens 5-11 27890818-0 2017 The anabolic steroid nandrolone alters cannabinoid self-administration and brain CB1 receptor density and function. Steroids 13-20 cannabinoid receptor 1 Rattus norvegicus 81-84 27553420-11 2017 Discontinuation of steroids during preoperative ANS-TGF-beta2 could be achieved in 10/16 patients (62.5%). Steroids 19-27 transforming growth factor beta 2 Homo sapiens 52-61 27773348-16 2017 This study offers new knowledge on the endometrial expression of ovarian steroids and OXT receptors in OXT pharmacologically induced luteal maintenance in the mare. Steroids 73-81 oxytocin/neurophysin I prepropeptide Homo sapiens 103-106 26757046-1 2016 OBJECTIVE: To quantify clinical outcome in patients with steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) after the acute phase and explore potential associations of initial serum thyroid peroxidase antibody titers (TPO-Abs) with outcome. Steroids 57-64 thyroid peroxidase Homo sapiens 247-250 27742828-5 2016 Proteomic analysis of steroid sensitive and resistant eosinophils identified several differentially expressed proteins, namely protein phosphatase 5 (PP5), formyl peptide receptor 2, and annexin 1. Steroids 22-29 annexin A1 Homo sapiens 187-196 27683264-9 2016 These effects on steroid production were reversed when cultured in the presence of ML221, an APLNR antagonist, which was associated with an increased 3beta-hydrosteroid dehydrogenase (HSD3B) protein concentration. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 184-189 27283773-6 2016 We used KLK6 knockout (KO) mice to evaluate KLK6 role in skin regeneration after steroid-induced atrophy. Steroids 81-88 kallikrein related-peptidase 6 Mus musculus 44-48 27769261-3 2016 GCR must be bound to molecular chaperones heat shock proteins (Hsp) 70 and Hsp90 to acquire a high-affinity steroid binding conformation, and traffic to the nucleus. Steroids 108-115 heat shock protein family A (Hsp70) member 4 Homo sapiens 47-70 27769261-4 2016 We hypothesized a loss of Hsp70/90 from these lymphocytes may further contribute to steroid resistance in COPD. Steroids 84-91 heat shock protein family A (Hsp70) member 4 Homo sapiens 26-31 27285831-5 2016 Only transcriptional levels of CYP17, CYP11A1, CYP19A, SRD5A1, and AKR1C-pig6 were correlated with the fat concentration of androstenone (0.57 < r < 0.70, P < 0.05) confirming that the amount of androstenone stored in fat is related to the production in testes of androstenone and more generally to all sex steroids. Steroids 316-324 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 31-36 27125452-10 2016 Thus, human CYP11B1 and CYP11B2 turned out to metabolize steroid-based drugs additionally to the liver-dependent biotransformation of drugs. Steroids 57-64 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 12-19 25727561-1 2016 Vitamin D is a steroid hormone, which in active form binds to the vitamin D receptor. Steroids 15-30 vitamin D receptor Homo sapiens 66-84 26658226-1 2016 The human mitochondrial cytochrome P450 enzymes CYP11A1, CYP11B1, and CYP11B2 are involved in the biosynthesis of steroid hormones. Steroids 114-130 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 57-64 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 183-199 steroidogenic acute regulatory protein Mus musculus 36-40 10462417-2 1999 The steroidogenic acute regulatory (StAR) protein is an indispensable component in the acute regulatory phase and functions by rapidly mediating the transfer of the substrate for all steroid hormones, cholesterol, from the outer to the inner mitochondrial membrane where it is cleaved to pregnenolone, the first steroid formed. Steroids 4-11 steroidogenic acute regulatory protein Mus musculus 36-40 26729801-11 2016 IL-17A independently contributes to AHR, but it only partially mediates inflammation and mucus metaplasia in a mixed Th2/Th17 model of steroid-resistant asthma. Steroids 135-142 interleukin 17A Mus musculus 0-6 10462417-4 1999 To underscore its importance, mutations in the StAR gene have been shown to be the only cause of the potentially fatal disease lipoid congenital adrenal hyperplasia, in which affected individuals synthesize virtually no steroids. Steroids 220-228 steroidogenic acute regulatory protein Mus musculus 47-51 26581634-4 2016 Steroid hormone production was increased significantly when MLTC-1 and Y1 cells were exposed to MBP at 10(-7)M. Additionally, vimentin and steroidogenic acute regulatory protein (StAR) expressions were upregulated at the same dose. Steroids 0-15 vimentin Mus musculus 126-134 27729871-1 2016 Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation. Steroids 135-143 lipocalin 2 Homo sapiens 0-11 27729871-1 2016 Lipocalin 2 (LCN2) is a secreted protein that belongs to the Lipocalins, a group of transporters of small lipophilic molecules such as steroids, lipopolysaccharides, iron, and fatty acids in circulation. Steroids 135-143 lipocalin 2 Homo sapiens 13-17 27657907-11 2016 CONCLUSIONS/SIGNIFICANCE: Our results suggest that BET proteins play an important role in the regulation of steroid-resistant exacerbations of airway inflammation and AHR. Steroids 108-115 delta/notch-like EGF repeat containing Mus musculus 51-54 27657907-12 2016 BET proteins may be potential targets for the development of future therapies to treat steroid-resistant inflammatory components of asthma. Steroids 87-94 delta/notch-like EGF repeat containing Mus musculus 0-3 26854589-1 2016 INTRODUCTION: Members of the CYP11B subfamily participate in the biosynthesis of important steroid hormones. Steroids 91-107 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 29-35 27296072-11 2016 We propose that these cytokine profiles may play an important role in the pathogenesis of inflammation after photocoagulation and the underlying mechanism of treatment with anti-VEGF drug and steroids. Steroids 192-200 vascular endothelial growth factor A Oryctolagus cuniculus 178-182 27125199-3 2016 By integrating steroid hormone signaling and growth factor pathways, SRC proteins exert multiple modes of oncogenic regulation in cancers and represent emerging targets for cancer therapeutics. Steroids 15-30 steroid receptor RNA activator 1 Homo sapiens 69-72 27489176-1 2016 Commentary: Conditional Steroidogenic Cell-Targeted Deletion of TSPO Unveils a Crucial Role in Viability and Hormone-Dependent Steroid Formation. Steroids 24-31 translocator protein Homo sapiens 64-68 26643407-4 2016 We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis. Steroids 186-193 phosphodiesterase 4B, cAMP specific Mus musculus 28-33 26643407-4 2016 We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis. Steroids 186-193 phosphodiesterase 8A Mus musculus 55-60 26643407-4 2016 We have recently shown that PDE4B and PDE4C as well as PDE8A and PDE8B are expressed in rodent Leydig cells and that combined inhibition of PDE4 and PDE8 leads to dramatically increased steroid biosynthesis. Steroids 186-193 phosphodiesterase 8A Mus musculus 55-59 27525332-0 2016 The effect of steroid hormones on the mRNA expression of oct4 and sox2 in uterine tissue of the ovariectomized mice model of menopause. Steroids 14-30 SRY (sex determining region Y)-box 2 Mus musculus 66-70 27525332-4 2016 OBJECTIVE: The present research evaluated the mRNA expression of oct4 and sox2 in the uterine tissues of ovariectomized mice treated with steroid hormones. Steroids 138-154 SRY (sex determining region Y)-box 2 Mus musculus 74-78 27525332-10 2016 CONCLUSION: The results indicate ovarian steroid hormones change the expression of oct4 and sox2 in the mice uterine tissues, which suggest the involvement of steroid hormonal regulation in uterine stem cells. Steroids 41-57 SRY (sex determining region Y)-box 2 Mus musculus 92-96 27525332-10 2016 CONCLUSION: The results indicate ovarian steroid hormones change the expression of oct4 and sox2 in the mice uterine tissues, which suggest the involvement of steroid hormonal regulation in uterine stem cells. Steroids 41-48 SRY (sex determining region Y)-box 2 Mus musculus 92-96 27099398-9 2016 KCNJ5(T158A) expression increased the synthesis of aldosterone and the hybrid steroids 18-hydroxycortisol and 18-oxocortisol, measured with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Steroids 78-86 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 0-5 27099398-11 2016 Overall, KCNJ5(T158A)increases CYP11B2 expression and production of aldosterone, corticosterone and hybrid steroids by upregulating both acute and chronic regulatory events in aldosterone production, and verapamil blocks KCNJ5(T158A)-mediated pathways leading to aldosterone production. Steroids 107-115 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 9-14 27357284-11 2016 Intrafollicular steroid disruption was partially reversed solely by postnatal insulin sensitizer treatment. Steroids 16-23 LOC105613195 Ovis aries 78-85 27357284-14 2016 The finding that final follicle growth was fully rescued by postnatal anti-androgen treatment and intrafollicular steroid milieu partially by insulin sensitizer treatment suggest that both androgenic and insulin pathway disruptions contribute to the compromised follicular phenotype of prenatal T-treated females. Steroids 114-121 LOC105613195 Ovis aries 142-149 27357284-14 2016 The finding that final follicle growth was fully rescued by postnatal anti-androgen treatment and intrafollicular steroid milieu partially by insulin sensitizer treatment suggest that both androgenic and insulin pathway disruptions contribute to the compromised follicular phenotype of prenatal T-treated females. Steroids 114-121 LOC105613195 Ovis aries 204-211 27347942-2 2016 The expression of the translocator protein in the brain and liver of healthy humans is usually low, oppositely to steroid-synthesizing and rapidly proliferating tissues, where TSPO is much more abundant. Steroids 114-121 translocator protein Homo sapiens 22-42 27094781-9 2016 These findings indicate that these TSPO ligands reduce oxidative stress and pro-inflammatory enzymes in glial cells through the de novo synthesis of neurosteroids, suggesting that these compounds could be potential new therapeutic tools for the treatment of inflammatory-based neuropathologies with beneficial effects possibly comparable to steroids, but potentially avoiding the negative side effects of long-term therapies with steroid hormones. Steroids 154-162 translocator protein Homo sapiens 35-39 27094781-9 2016 These findings indicate that these TSPO ligands reduce oxidative stress and pro-inflammatory enzymes in glial cells through the de novo synthesis of neurosteroids, suggesting that these compounds could be potential new therapeutic tools for the treatment of inflammatory-based neuropathologies with beneficial effects possibly comparable to steroids, but potentially avoiding the negative side effects of long-term therapies with steroid hormones. Steroids 154-161 translocator protein Homo sapiens 35-39 27280155-14 2016 Manipulation of specific sex steroids suggests that estradiol induces the changes that enhance AVPV kisspeptin neuron excitability on proestrus. Steroids 29-37 KiSS-1 metastasis-suppressor Mus musculus 100-110 27147573-8 2016 Our results suggest that stress hormone induced tumorigenesis would be achieved by MTOC amplification, and CSH1 would be useful for prevention of stress-hormone or steroid hormone-induced chromosomal instability. Steroids 164-179 chorionic somatomammotropin hormone 1 Homo sapiens 107-111 27183596-0 2016 Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-gamma-Induced IL-27 and Airway Hyperresponsiveness in Mice. Steroids 25-32 interleukin 27 Mus musculus 91-96 27183596-2 2016 Combined LPS/IFN-gamma strongly upregulates IL-27 production, which has been linked to steroid-resistant airway hyperresponsiveness (AHR). Steroids 87-94 interleukin 27 Mus musculus 44-49 27183596-4 2016 The present study investigated whether andrographolide could restore steroid sensitivity to block LPS/IFN-gamma-induced IL-27 production and AHR via its antioxidative property. Steroids 69-76 interleukin 27 Mus musculus 120-125 27093227-0 2016 Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice. Steroids 67-74 KiSS-1 metastasis-suppressor Mus musculus 43-48 27093227-9 2016 Therefore, POMC and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC) neurons in male mice, which may be a critical pathway for Kiss1 neurons to help coordinate energy homeostasis and reproduction. Steroids 48-55 KiSS-1 metastasis-suppressor Mus musculus 115-125 27093227-9 2016 Therefore, POMC and AgRP neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1(ARC) neurons in male mice, which may be a critical pathway for Kiss1 neurons to help coordinate energy homeostasis and reproduction. Steroids 48-55 KiSS-1 metastasis-suppressor Mus musculus 115-120 27223301-3 2016 Here, we analyzed the immunogenicity of MVA vectors harboring the simultaneous deletion of A44L, related to steroid synthesis and A46R, a TLR-signaling inhibitor (MVADeltaA44L-A46R); or also including a deletion of C12L (MVADeltaC12L/DeltaA44L-A46R). Steroids 108-115 hydroxysteroid dehydrogenase Vaccinia virus 91-95 27195771-6 2016 Through Ca2+ imaging in native VNO cells we show that virus-induced overexpression of V1rj2, V2r1b or Fpr3 caused a pronounced increase of responsivity to sulfated steroids, MHC-binding peptide or the synthetic hexapeptide W-peptide, respectively. Steroids 164-172 formyl peptide receptor 3 Homo sapiens 102-106 27242666-4 2016 Both acute and chronic ACTH treatments can modulate SR-B1 function, including its transcription, posttranscriptional stability, phosphorylation and dimerization status, as well as the interaction with other protein partners, all of which result in changes in the ability of SR-B1 to mediate HDL-CE uptake and the supply of cholesterol for conversion to steroids. Steroids 353-361 scavenger receptor class B member 1 Homo sapiens 52-57 27242666-4 2016 Both acute and chronic ACTH treatments can modulate SR-B1 function, including its transcription, posttranscriptional stability, phosphorylation and dimerization status, as well as the interaction with other protein partners, all of which result in changes in the ability of SR-B1 to mediate HDL-CE uptake and the supply of cholesterol for conversion to steroids. Steroids 353-361 scavenger receptor class B member 1 Homo sapiens 274-279 26722017-8 2016 This mechanism may be disturbed in women using HC, suggesting that gonadal steroids could alter partner-specific OXT effects. Steroids 75-83 oxytocin/neurophysin I prepropeptide Homo sapiens 113-116 27115344-4 2016 Utilizing both genetic and pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7). Steroids 75-82 G protein-coupled estrogen receptor 1 Homo sapiens 180-215 27115344-4 2016 Utilizing both genetic and pharmacologic approaches, we establish that sex steroid effects on human pigment synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7). Steroids 75-82 G protein-coupled estrogen receptor 1 Homo sapiens 217-221 26352216-2 2016 A critical element in maintaining sex steroid levels is the enzyme aromatase (cytochrome P450 19A1) which converts androgens to oestrogens. Steroids 38-45 aromatase Oryzias latipes 78-98 26482144-3 2016 The aim was to confirm the accuracy of the immunohistochemical approach in the detection of the over-expression of the progesterone receptor induced by the administration of sexual steroids at low levels (17beta-estradiol and nandrolone alone or in combination). Steroids 181-189 progesterone receptor Bos taurus 119-140 26363452-6 2016 Similar to other vertebrates, CBP was expressed at relatively high levels in steroid-sensitive brain regions. Steroids 77-84 LOW QUALITY PROTEIN: CREB-binding protein Anolis carolinensis 30-33 26657863-4 2016 The chemical screen led to the identification of 3 steroid molecules, epitiostanol, progesterone, and mifepristone, which decrease ferroportin levels by increasing the biosynthesis of hepcidin. Steroids 51-58 hepcidin antimicrobial peptide Mus musculus 184-192 26657863-5 2016 These hepcidin-inducing steroids (HISs) did not activate known hepcidin-inducing pathways, including the BMP and JAK/STAT3 pathways. Steroids 24-32 hepcidin antimicrobial peptide Mus musculus 6-14 26138474-0 2016 The Influence of Gonadal Steroid Hormones on Immunoreactive Kisspeptin in the Preoptic Area and Arcuate Nucleus of Developing Agonadal Mice with a Genetic Disruption of Steroidogenic Factor 1. Steroids 25-32 KiSS-1 metastasis-suppressor Mus musculus 60-70 26138474-2 2016 The aim of the present study was to determine contributions of genetic factors and gonadal steroid hormones to the sexual differentiation of kisspeptin-immunoreactive (kisspeptin-ir) cell populations in the AVPV and Arc during postnatal development using agonadal steroidogenic factor 1 (SF-1) knockout (KO) mice. Steroids 91-107 KiSS-1 metastasis-suppressor Mus musculus 141-151 27125740-1 2016 Klotho protein is a beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. Steroids 62-69 klotho Homo sapiens 0-6 26452104-8 2015 The key steroid hormones and steroidogenic genes are dramatically decreased in double knockout mutant (fshb;lhb and fshr;lhr) but not in single knockout mutant (fshb, lhb, fshr, and lhr) males. Steroids 8-24 follicle stimulating hormone subunit beta Danio rerio 103-107 26432642-4 2015 Br-BPTC acts from the C-terminal extracellular sequences of alpha4 subunits, which is also a PAM site for steroid hormone estrogens such as 17beta-estradiol. Steroids 106-121 peptidylglycine alpha-amidating monooxygenase Homo sapiens 93-96 26580071-6 2015 MAMLD1 expression in normal steroid-producing tissues and mutant MAMLD1 protein expression were also assessed. Steroids 28-35 mastermind like domain containing 1 Homo sapiens 0-6 26241911-0 2015 Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues. Steroids 64-71 glutamate dehydrogenase 2 Homo sapiens 30-35 26241911-3 2015 Results revealed high levels of hGDH1 and hGDH2 expression in steroid-producing cells in all tissues studied. Steroids 62-69 glutamate dehydrogenase 2 Homo sapiens 42-47 26241911-6 2015 As synthesis of steroid hormones requires NADPH, expression of hGDH1 and hGDH2 in steroidogenic cells may serve their particular metabolic needs. Steroids 16-32 glutamate dehydrogenase 2 Homo sapiens 73-78 26404398-1 2015 Bioactive vitamin D is a steroid hormone transported in blood via the vitamin D binding protein (DBP). Steroids 25-40 GC vitamin D binding protein Homo sapiens 70-95 26805235-4 2015 Although the levels of KL-6 and SP-D, markers of interstitial pneumonia, decreased after steroid and immunosuppressive therapy, the CT findings of interstitial pneumonia showed no remarkable change. Steroids 89-96 surfactant protein D Homo sapiens 32-36 25917347-1 2015 Vascular hyperpermeability and highly upregulated bone resorption in the destructive repair progress of steroid-associated osteonecrosis (SAON) are associated with a high expression of VEGF and high Src activity (Src is encoded by the cellular sarcoma [c-src] gene). Steroids 104-111 vascular endothelial growth factor A Oryctolagus cuniculus 185-189 25917347-12 2015 Blockage of VEGF-Src signaling pathway by specific Src siRNA was able to prevent steroid-associated destructive repair while improving reconstructive repair in SAON, which might become a novel therapeutic strategy. Steroids 81-88 vascular endothelial growth factor A Oryctolagus cuniculus 12-16 26466988-8 2015 RESULTS: The study showed significant correlations of cathepsin B with the time since renal transplantation (p<0.05) and steroid used in the primary and current treatment. Steroids 124-131 cathepsin B Homo sapiens 54-65 26466988-9 2015 Steroid treatment is associated with a decrease of the activity of cathepsin B in serum. Steroids 0-7 cathepsin B Homo sapiens 67-78 26466988-11 2015 We have shown that steroids decrease activity of cathepsin B after renal transplantation. Steroids 19-27 cathepsin B Homo sapiens 49-60 26466988-13 2015 Decreased activity of cathepsin B is probably due to the stabilizing action of steroids on the lysosomal membrane. Steroids 79-87 cathepsin B Homo sapiens 22-33 26465152-0 2015 A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology. Steroids 68-75 calcineurin binding protein 1 Homo sapiens 116-137 26122391-3 2015 It has also been attempted to answer the question whether or not SF-1 plays a role in the PKA-induced expression of LIPE gene encoding hormone-sensitive lipase/cholesteryl esterase, which supplies cholesterol for steroid hormone synthesis. Steroids 213-228 lipase, hormone sensitive Mus musculus 116-120 26122391-3 2015 It has also been attempted to answer the question whether or not SF-1 plays a role in the PKA-induced expression of LIPE gene encoding hormone-sensitive lipase/cholesteryl esterase, which supplies cholesterol for steroid hormone synthesis. Steroids 213-228 lysosomal acid lipase A Mus musculus 160-180 26028607-6 2015 Microarray assay demonstrated that oxLDL strongly affected two metabolic and signaling transduction pathways: the biosynthesis of steroids, via modification of nine genes that act sequentially in this metabolic pathway, and the Jak-Stat signaling pathway acting through STAT1 and STAT2. Steroids 130-138 signal transducer and activator of transcription 1 Homo sapiens 270-275 26028607-6 2015 Microarray assay demonstrated that oxLDL strongly affected two metabolic and signaling transduction pathways: the biosynthesis of steroids, via modification of nine genes that act sequentially in this metabolic pathway, and the Jak-Stat signaling pathway acting through STAT1 and STAT2. Steroids 130-138 signal transducer and activator of transcription 2 Homo sapiens 280-285 26420286-2 2015 Mutations in more than 24 genes have been associated with nephrotic syndrome in children, although the great majority of steroid-resistant cases have been attributed to mutations in three main genes: NPHS1, NPHS2 and WT1. Steroids 121-128 NPHS1 adhesion molecule, nephrin Homo sapiens 200-205 26203177-7 2015 We demonstrate that, in primary mouse granulosa cells, LH triggers release of soluble amphiregulin that correlates with steroid production, both of which are blocked by MMP2/9 inhibition, confirming that MMP2/9 likely regulates LH-induced amphiregulin release and downstream processes. Steroids 120-127 matrix metallopeptidase 2 Mus musculus 169-175 25772594-0 2015 Distinct endotypes of steroid-resistant asthma characterized by IL-17A(high) and IFN-gamma(high) immunophenotypes: Potential benefits of calcitriol. Steroids 22-29 interleukin 17A Homo sapiens 64-70 25823708-7 2015 RESULTS: The functional sensitivity of our steroid analysis was <1 3, <9 3, 2 3, <1 3, <15 9, 1 87 pg/mg hair for cortisol, cortisone, testosterone, androstenedione, dehydroepiandrosterone sulphate (DHEAS), and 17OHP, respectively. Steroids 43-50 sulfotransferase family 2A member 1 Homo sapiens 211-216 25960318-2 2015 The effects of celecoxib on the sulfonation of selected steroids catalyzed by human SULT2A1 were assessed through in vitro and in silico studies. Steroids 56-64 sulfotransferase family 2A member 1 Homo sapiens 84-91 26245218-5 2015 SF-1 and LRH-1 are essential for steroid hormone production in gonads and adrenal glands through the regulation of various steroidogenesis-related genes. Steroids 33-48 splicing factor 1 Homo sapiens 0-4 26185616-9 2015 Valproic acid, a HDAC inhibitor, suppressed the growth of AR/cPAcP-positive PCa cells by over 50% in steroid-reduced conditions, higher than on AR/cPAcP-negative PCa cells. Steroids 101-108 histone deacetylase 9 Homo sapiens 17-21 25951771-12 2015 The present study, therefore, provided evidence of an autocrine/paracrine role of IGFs in follicular development and a stimulatory role of IGF1 in steroid production in GC of preovulatory follicles in the bubaline species. Steroids 147-154 insulin-like growth factor I Bubalus bubalis 139-143 25037120-1 2015 Steroid applications are able to repress inflammatory activity in various conditions, including herniation of the nucleus pulposus (HNP), by inhibiting tumour necrosis factor (TNF)-alpha, but the effects of long-term use are unknown. Steroids 0-7 kallikrein related peptidase 8 Homo sapiens 132-135 25037120-10 2015 Hence, blockade of sub-acute inflammatory changes in HNP can be achieved by early injection of steroids, whereas long-term injection of a steroid may initiate NF-kappaB autophosphorylation. Steroids 95-103 kallikrein related peptidase 8 Homo sapiens 53-56 25037120-10 2015 Hence, blockade of sub-acute inflammatory changes in HNP can be achieved by early injection of steroids, whereas long-term injection of a steroid may initiate NF-kappaB autophosphorylation. Steroids 95-102 kallikrein related peptidase 8 Homo sapiens 53-56 25818881-2 2015 TSPO is a drug- and cholesterol-binding protein found at particularly high levels in steroid synthesizing cells. Steroids 85-92 translocator protein Homo sapiens 0-4 25818881-8 2015 TSPO drug ligands have been proposed as therapeutic agents to regulate steroid levels in the brain and testis. Steroids 71-78 translocator protein Homo sapiens 0-4 25784721-1 2015 Salmeterol is a long-acting beta2-adrenergic receptor (beta2AR) agonist that is widely used as a bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary disease in conjunction with steroids. Steroids 213-221 adrenoceptor beta 2 Homo sapiens 28-53 25784721-1 2015 Salmeterol is a long-acting beta2-adrenergic receptor (beta2AR) agonist that is widely used as a bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary disease in conjunction with steroids. Steroids 213-221 adrenoceptor beta 2 Homo sapiens 55-62 25993987-1 2015 INTRODUCTION: The established neuroprotective property of the sex steroid precursor dehydroepiandrosterone-sulfate (DHEAS) has not yet been investigated in the context of aneurysmal subarachnoid hemorrhage (aSAH). Steroids 66-73 sulfotransferase family 2A member 1 Homo sapiens 116-121 25567291-1 2015 Multi-drug resistance (MDR)-ATP binding cassette (ABC) transporters, ABCB1, ABCC1, and ABCG2 participate in the efflux of steroid hormones, estrogens, and androgens, which regulate prostate development and differentiation. Steroids 122-138 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 76-81 25814531-2 2015 Increased levels of soluble ST2 (sST2) are a biomarker for steroid-refractory graft-versus-host disease (GVHD) and mortality. Steroids 59-66 ST2 Homo sapiens 28-31 25892890-3 2015 We present the case of a patient suffering from childhood-onset, multidrug resistant and steroid-dependent Crohn"s disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient"s peripheral blood mononuclear cells. Steroids 89-96 C-X-C motif chemokine receptor 4 Homo sapiens 217-222 25704974-2 2015 However, whether endogenous sexual steroid hormones also influence the hepatic GH receptor (GHR) signaling pathway during a physiological estrus cycle remains unclear. Steroids 35-42 growth hormone receptor Bos taurus 92-95 25640859-7 2015 Steroid-inducible gene expression analyses and chromatin immunoprecipitation (ChIP) experiments suggest that GIS and GIS2 are the direct target genes of GIS3. Steroids 0-7 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 109-112 25721668-1 2015 The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. Steroids 92-99 nuclear receptor subfamily 1 group I member 3 Homo sapiens 4-36 25322273-0 2015 Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production. Steroids 99-106 translocator protein Homo sapiens 53-73 25322273-0 2015 Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production. Steroids 99-106 translocator protein Homo sapiens 75-79 25322273-3 2015 Cholesterol trafficking is the limiting step in sex steroid biosynthesis and is mainly mediated by the translocator protein (TSPO), present in the mitochondrial outer membrane. Steroids 52-59 translocator protein Homo sapiens 103-123 25322273-3 2015 Cholesterol trafficking is the limiting step in sex steroid biosynthesis and is mainly mediated by the translocator protein (TSPO), present in the mitochondrial outer membrane. Steroids 52-59 translocator protein Homo sapiens 125-129 25313167-5 2015 RESULTS: In KTx, steroid intake was associated with higher total, CD14(++)CD16(-) and CD14(++)CD16(+) monocyte counts, but fewer CD14(+)CD16(++) monocytes, whereas intake of mycophenolate, calcineurin inhibitors (CNI) and mammalian target of rapamycin inhibitors (mTORI) did not affect monocyte (subset) counts. Steroids 17-24 Fc gamma receptor IIIa Homo sapiens 74-78 25313167-5 2015 RESULTS: In KTx, steroid intake was associated with higher total, CD14(++)CD16(-) and CD14(++)CD16(+) monocyte counts, but fewer CD14(+)CD16(++) monocytes, whereas intake of mycophenolate, calcineurin inhibitors (CNI) and mammalian target of rapamycin inhibitors (mTORI) did not affect monocyte (subset) counts. Steroids 17-24 Fc gamma receptor IIIa Homo sapiens 94-98 25313167-5 2015 RESULTS: In KTx, steroid intake was associated with higher total, CD14(++)CD16(-) and CD14(++)CD16(+) monocyte counts, but fewer CD14(+)CD16(++) monocytes, whereas intake of mycophenolate, calcineurin inhibitors (CNI) and mammalian target of rapamycin inhibitors (mTORI) did not affect monocyte (subset) counts. Steroids 17-24 Fc gamma receptor IIIa Homo sapiens 94-98 25313167-10 2015 CONCLUSION: Chronic low-dose steroids are associated with monocytosis and higher counts of CD14(++)CD16(-) and of proinflammatory CD14(++)CD16(+) monocytes. Steroids 29-37 Fc gamma receptor IIIa Homo sapiens 99-103 25313167-10 2015 CONCLUSION: Chronic low-dose steroids are associated with monocytosis and higher counts of CD14(++)CD16(-) and of proinflammatory CD14(++)CD16(+) monocytes. Steroids 29-37 Fc gamma receptor IIIa Homo sapiens 138-142 25791538-10 2015 CONCLUSIONS: Interactions between BDNF, the hypothalamus-pituitary-adrenal axis, and sex steroids might be critical in clinical conditions of modified homeostasis/adaptation, such as FHA. Steroids 89-97 brain derived neurotrophic factor Homo sapiens 34-38 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 70-77 26680489-3 2015 In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites). Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 201-208 25238745-7 2014 Irrespective of the expression system, receptors resulting from combining the tandem construct beta2-delta and a free alpha4 subunit exhibited large steroid responses. Steroids 149-156 immunoglobulin binding protein 1 Homo sapiens 118-124 26781490-3 2016 The present study aims to detect the distribution and cyclic variations of Herp during the estrous cycle and to reveal the roles of Herp in regulating the cell cycle, apoptosis and steroid hormone biosynthesis in mouse granulosa cells. Steroids 181-196 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Mus musculus 132-136 10588069-1 1999 Sesquiterpene cyclase and squalene synthase are key branch point enzymes in isoprenoid pathway for the synthesis of sesquiterpenoid phytoalexins and sterols/steroid glycoalkaloids, respectively. Steroids 157-164 squalene synthase Solanum tuberosum 26-43 27007229-5 2016 Best platelet response to steroid treatment was found among GC genotype of IL-6 (-174) and GG genotype of IL-10 (-1082) in all patients with ITP. Steroids 26-33 interleukin 10 Homo sapiens 106-111 27007229-8 2016 IL-6 (-174) and IL-10 (-1082) genes might play a role in the effectiveness of steroid therapy among patients with ITP. Steroids 78-85 interleukin 10 Homo sapiens 16-21 26704533-5 2016 The steroid levels (47 steroids and steroid polar conjugates) and their ratios in AD female patients indicated increased CYP11A1 activity, weakened activity of the CYP17A1C17,20 lyase metabolic step and attenuated sulfotransferase SULT2A1 activity at higher activity of the CYP17A1 17-hydroxylase step. Steroids 4-11 sulfotransferase family 2A member 1 Homo sapiens 231-238 25162311-10 2014 We summarize and discuss the implications of IL-17 in the induction of neutrophilic airway inflammation, steroid insensitivity, the epithelial cell profile, and airway remodeling. Steroids 105-112 interleukin 17A Homo sapiens 45-50 25377354-4 2014 Here we report the molecular requirements for the recognition of steroid receptors (SRs) by the lincRNA growth arrest-specific 5 (Gas5), which regulates steroid-mediated transcriptional regulation, growth arrest and apoptosis. Steroids 65-72 growth arrest specific 5 Homo sapiens 104-128 10428861-3 1999 Heme regulation of Hap1 activity is analogous to the regulation of steroid receptors by steroids, which involves molecular chaperones. Steroids 88-96 Hap1p Saccharomyces cerevisiae S288C 19-23 25377354-4 2014 Here we report the molecular requirements for the recognition of steroid receptors (SRs) by the lincRNA growth arrest-specific 5 (Gas5), which regulates steroid-mediated transcriptional regulation, growth arrest and apoptosis. Steroids 65-72 growth arrest specific 5 Homo sapiens 130-134 25124713-0 2014 Non-eosinophilic airway hyper-reactivity in mice, induced by IFN-gamma producing CD4(+) and CD8(+) lung T cells, is responsive to steroid treatment. Steroids 130-137 CD4 antigen Mus musculus 81-84 25370848-8 2016 These results indicate that EDNs are produced by epithelial cells and their target site is smooth-muscle and epithelial cells, and suggest that ovarian steroids are regulators of endothelin synthesis in ampullary oviductal epithelial cells. Steroids 152-160 endothelin 1 Bos taurus 179-189 26706618-0 2016 Discontinuation of steroids in ABO-incompatible renal transplantation. Steroids 19-27 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 31-34 10442637-0 1999 Steroid hormones modulate H19 gene expression in both mammary gland and uterus. Steroids 0-16 H19 imprinted maternally expressed transcript Homo sapiens 26-29 26706618-1 2016 A steroid-free protocol for ABO-compatible renal transplantation has been used at our center since 1983. Steroids 2-9 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 28-31 26853319-8 2016 Putative binding sites in proximal promoter regions of CYP20A1s, and response of zebrafish CYP20A1 to selected nuclear and xenobiotic receptor agonists, point to up-regulation by agents involved in steroid hormone response, cholesterol and lipid metabolism. Steroids 198-213 cytochrome P450, family 20, subfamily A, polypeptide 1 Danio rerio 55-62 25356728-6 2014 LuCaP35 demonstrated higher expression of steroid biosynthetic enzymes maintaining DHT levels (5-fold higher SRD5A1, 41 fold higher, 99-fold higher RL-HSD, p<0.0001 for both), reconstitution of intra-tumoral DHT (to ~30% of untreated tumors), and ~2 fold increased expression of full length AR. Steroids 42-49 steroid 5 alpha-reductase 1 Homo sapiens 109-115 25313867-7 2014 Interestingly, human Mitofusin-2 rescues the loss of LD but both Mitofusin-1 and Mitofusin-2 are required for steroid-hormone synthesis. Steroids 110-125 mitofusin 2 Homo sapiens 21-32 25313867-7 2014 Interestingly, human Mitofusin-2 rescues the loss of LD but both Mitofusin-1 and Mitofusin-2 are required for steroid-hormone synthesis. Steroids 110-125 mitofusin 1 Homo sapiens 65-76 10442637-3 1999 To determine the mode of steroid action, we have detected levels of H19 RNA synthesis during mammary gland development by in situ hybridization (ISH): two peaks of H19 transcription occur during puberty and pregnancy. Steroids 25-32 H19 imprinted maternally expressed transcript Homo sapiens 68-71 25313867-7 2014 Interestingly, human Mitofusin-2 rescues the loss of LD but both Mitofusin-1 and Mitofusin-2 are required for steroid-hormone synthesis. Steroids 110-125 mitofusin 2 Homo sapiens 81-92 10442637-3 1999 To determine the mode of steroid action, we have detected levels of H19 RNA synthesis during mammary gland development by in situ hybridization (ISH): two peaks of H19 transcription occur during puberty and pregnancy. Steroids 25-32 H19 imprinted maternally expressed transcript Homo sapiens 164-167 10442637-15 1999 We have thus demonstrated that H19 gene expression is controlled by steroid hormones; furthermore, this gene is highly expressed in hormone-sensitive organs when the hormonal stimulation is accompanied with a morphological repair. Steroids 68-84 H19 imprinted maternally expressed transcript Homo sapiens 31-34 26853319-8 2016 Putative binding sites in proximal promoter regions of CYP20A1s, and response of zebrafish CYP20A1 to selected nuclear and xenobiotic receptor agonists, point to up-regulation by agents involved in steroid hormone response, cholesterol and lipid metabolism. Steroids 198-213 cytochrome P450, family 20, subfamily A, polypeptide 1 Danio rerio 91-98 10452346-11 1999 In steroid-treated heart transplant recipients, the hypofibrinolytic state was due to a significant and pathological increase in PAI-1 antigen and activity levels. Steroids 3-10 serpin family E member 1 Homo sapiens 129-134 26096934-0 2016 Steroid induction of therapy-resistant cytokeratin-5-positive cells in estrogen receptor-positive breast cancer through a BCL6-dependent mechanism. Steroids 0-7 BCL6 transcription repressor Homo sapiens 122-126 10452346-16 1999 Among the 12 transplant recipients who developed cardiac microthrombi, 7 patients were treated with steroids and showed higher PAI-1 levels and more reduced fibrinolytic activity than the 5 steroid-free patients. Steroids 100-108 serpin family E member 1 Homo sapiens 127-132 26938869-1 2016 Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology. Steroids 65-72 sulfotransferase family 2A member 1 Homo sapiens 32-37 24818590-11 2014 CONCLUSION: The addition of prednisolone to heparin and low dose aspirin might be beneficial in patients with unexplained recurrent miscarriage, and this effect might be due to a suppressive effect of steroids on the peripheral CD16 NK cells concentration. Steroids 201-209 Fc gamma receptor IIIa Homo sapiens 228-232 10452346-16 1999 Among the 12 transplant recipients who developed cardiac microthrombi, 7 patients were treated with steroids and showed higher PAI-1 levels and more reduced fibrinolytic activity than the 5 steroid-free patients. Steroids 100-107 serpin family E member 1 Homo sapiens 127-132 26938869-10 2016 Taken together, these results are consistent with the effects of DHEAS being mediated through a membrane-bound G-protein-coupled receptor interacting with Gnalpha11 in a signaling pathway that resembles the non-classical signaling pathways of steroid hormones. Steroids 243-250 sulfotransferase family 2A member 1 Homo sapiens 65-70 10369386-2 1999 To investigate how the steroid hormones of pregnancy might regulate this expression, in situ hybridization was used to monitor the levels of EGF mRNA in endometrial biopsies obtained from seasonally anoestrous or ovariectomised mares given exogenous progesterone and oestrogen, alone or in combination, for up to 46 days. Steroids 23-30 LOW QUALITY PROTEIN: pro-epidermal growth factor Equus asinus 141-144 26938869-11 2016 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids 135-150 sulfotransferase family 2A member 1 Homo sapiens 26-31 26938869-11 2016 Considering the fact that DHEAS is produced in reproductive organs, these findings also suggest that DHEAS, by acting as an autonomous steroid hormone and influencing the formation and dynamics of the TJ at the blood-testis barrier, might play a crucial role for the regulation and maintenance of male fertility. Steroids 135-150 sulfotransferase family 2A member 1 Homo sapiens 101-106 25917060-11 2016 Interleukin-6 levels were lower at 6 and 24 hours post-operatively (p<0.001), and Interleukin-10 levels were higher 6 hours post-operatively (p<0.001) in the steroid group. Steroids 164-171 interleukin 10 Homo sapiens 85-99 24105099-1 2014 Microsomal cytochrome b5 plays a key role in the oxidation of a variety of exogenous and endogenous compounds, including drugs, fatty acids, cholesterol and steroid hormones. Steroids 157-173 cytochrome b5 Oryctolagus cuniculus 11-24 10381541-6 1999 It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region. Steroids 194-201 progesterone receptor Rattus norvegicus 49-51 25092028-0 2014 Identification of 9alpha-hydroxy-17-oxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid in steroid degradation by Comamonas testosteroni TA441 and its conversion to the corresponding 6-en-5-oyl coenzyme A (CoA) involving open reading frame 28 (ORF28)- and ORF30-encoded acyl-CoA dehydrogenases. Steroids 85-92 Orf30 Comamonas testosteroni 250-255 25111374-1 2014 Atrial natriuretic peptide (ANP) is known to regulate ovarian functions, such as follicular growth and steroid hormone production. Steroids 103-118 natriuretic peptide A Rattus norvegicus 0-26 26702050-8 2016 Transfection of miR-29b-3p mimics into cardiac fibroblasts inhibited cardiotonic steroids-induced collagen synthesis. Steroids 81-89 microRNA mir-29b-3 Rattus norvegicus 16-26 25111374-1 2014 Atrial natriuretic peptide (ANP) is known to regulate ovarian functions, such as follicular growth and steroid hormone production. Steroids 103-118 natriuretic peptide A Rattus norvegicus 28-31 25111374-11 2014 Together with previous evidence demonstrating that ANP inhibits ovarian steroidogenesis, these findings suggest that low ovarian ANP levels may contribute to the abnormal steroid hormone balance in polycystic ovaries. Steroids 171-186 natriuretic peptide A Rattus norvegicus 129-132 26600259-5 2016 SUMMARY: Steroid resistant severe asthma with predominant bronchial neutrophilic inflammation could benefit from IL-17 targeted therapies. Steroids 9-16 interleukin 17A Homo sapiens 113-118 10381541-6 1999 It has been observed that: (1) the messenger for PR is present in Schwann cells; (2) DHT may activate the transcriptional activity of a PR-responsive gene by binding to the PR; and (3) putative steroid responsive elements have been described in this paper to be present in the Po promoter region. Steroids 194-201 progesterone receptor Rattus norvegicus 136-138 10342851-6 1999 Moreover, although the endometrial stromal cells expressed another src-family kinase, Fyn, the activity of the Fyn kinase was almost undetectable during decidualization and thereafter upon steroid withdrawal. Steroids 189-196 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 111-114 24985084-1 2014 OBJECTIVE: To identify the expression profile and sex steroid regulation pattern of myeloid ecotropic viral integration site 1 (MEIS1) in endometrium. Steroids 54-61 Meis homeobox 1 Homo sapiens 84-126 24985084-1 2014 OBJECTIVE: To identify the expression profile and sex steroid regulation pattern of myeloid ecotropic viral integration site 1 (MEIS1) in endometrium. Steroids 54-61 Meis homeobox 1 Homo sapiens 128-133 24985084-8 2014 In addition, MEIS1 expression in response to sex steroid was examined both in vitro and in vivo by immunohistochemistry staining and western blot. Steroids 49-56 Meis homeobox 1 Homo sapiens 13-18 10372664-0 1999 Clinical review 107: Role of gonadal steroids in the sexual dimorphisms in body composition and circulating concentrations of leptin. Steroids 37-45 leptin Homo sapiens 126-132 24985084-10 2014 Steroid hormones increased MEIS1 expression in primary cultured endometrial stromal cells, Ishikawa cells, and endometrium of oophorectomized mice. Steroids 0-16 Meis homeobox 1 Homo sapiens 27-32 24985084-13 2014 CONCLUSION(S): MEIS1 is likely a key mediator between sex steroid and genes for uterine receptivity. Steroids 58-65 Meis homeobox 1 Homo sapiens 15-20 24998469-4 2014 AREAS COVERED: This review examines growing evidence for the important role played by the steroid hormone-induced gene called GREB1, or growth regulation by estrogen in breast cancer 1. Steroids 90-105 growth regulating estrogen receptor binding 1 Homo sapiens 126-131 26639173-6 2016 Through the interaction of HSL with vimentin and StAR, FC is translocated to mitochondria for steroid hormone production. Steroids 94-109 lipase, hormone sensitive Mus musculus 27-30 26639173-6 2016 Through the interaction of HSL with vimentin and StAR, FC is translocated to mitochondria for steroid hormone production. Steroids 94-109 vimentin Mus musculus 36-44 10098511-1 1999 The steroidogenic acute regulatory (StAR) protein, a 30-kDa mitochondrial factor, is a key regulator of steroid hormone biosynthesis, facilitating the transfer of cholesterol from the outer to the inner mitochondrial membrane. Steroids 104-119 steroidogenic acute regulatory protein Mus musculus 36-40 10198852-9 1999 Mean Tono-Pen IOP in steroid-treated post-PRK eyes was 4.3 +/- 3 mm Hg higher than in the fellow eyes (P = .0014); mean GAT IOP was only 2.3 +/- 3.5 mm Hg higher (P = .04). Steroids 21-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 26900322-12 2016 CONCLUSIONS: Our results indicate that CFI polymorphisms are not significantly associated with VKH syndrome; nevertheless, we identified a trend for the association of CFI-7356506 with VKH syndrome that depends on the recurrent status and the complicated cataract status but not on the steroid-sensitive status. Steroids 286-293 complement factor I Homo sapiens 168-171 25451758-3 2014 Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Steroids 56-72 KIT ligand Homo sapiens 115-118 24554068-0 2014 STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head. Steroids 65-72 signal transducer and activator of transcription 1 Homo sapiens 0-5 10076123-4 1999 RESULTS: In women receiving oral contraceptives, insulin-like growth factor binding protein 1 remained highly phosphorylated and levels were acutely increased by sex steroid treatment (305 +/- 110 microg/L on day 14 of the cycle [medication phase] vs 118 +/- 70 microg/L during the medication-free period, P <.03). Steroids 166-173 insulin like growth factor binding protein 1 Homo sapiens 49-93 26646591-0 2016 Low beta2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. Steroids 112-119 adrenoceptor beta 2 Homo sapiens 4-29 26750656-1 2016 The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. Steroids 121-129 translocator protein Homo sapiens 58-78 10188912-15 1999 The mutations in the core enhancer and promoter region probably contribute to the aberrant expression of the PSA gene in breast tumours, possibly by altering the regulation of the gene by steroid hormones. Steroids 188-204 kallikrein related peptidase 3 Homo sapiens 109-112 26750656-1 2016 The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. Steroids 121-129 translocator protein Homo sapiens 80-84 24980500-8 2014 The negative sex steroid feedback was found to act specifically on arcuate Kiss1 expression. Steroids 17-24 KiSS-1 metastasis suppressor Homo sapiens 75-80 10098601-1 1999 The steroidogenic enzyme P450c17 (17alpha hydroxylase/C17,20 lyase) regulates a key branchpoint in steroidogenesis, as its activity directs the steroid biosynthetic pathways toward glucocorticoid or sex hormone synthesis. Steroids 4-11 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 25-32 24944817-10 2014 The data indicate that the polymorphism of the RANTES promoter is not directly associated with the susceptibility to UC, but the -28 G allele is associated with female UC patients and mild clinical phenotypes of UC, including non-steroid dependency, non-refractory and rectal colitis. Steroids 230-237 C-C motif chemokine ligand 5 Homo sapiens 47-53 26462575-3 2016 Through the synthesis of new compounds and their examination by a combination of cell-based assays and real-time interaction analysis by surface plasmon resonance, we showed at molecular level that l-tryptophan conjugates of lithocholic acid disrupt EphA2-ephrin-A1 interaction by targeting the EphA 2 receptor and that the presence of a polar group in position 3 of steroid scaffold is a key factor to increase the effective concentration of the compounds in cancer cell lines. Steroids 367-374 EPH receptor A2 Homo sapiens 250-255 26646255-12 2016 Female sex steroids and vitamin-D promoted tendon-derived cell proliferation via estrogen receptor alpha and VDR, not estrogen receptor beta. Steroids 11-19 vitamin D receptor Homo sapiens 109-112 26573708-7 2016 The hybrid steroid 18-oxocortisol exhibited 18- and 16-fold higher concentrations in lateralized AV and PV plasma, respectively, from APA with KCNJ5 mutations compared with all other APA combined together (P<0.001). Steroids 11-18 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 143-148 25905237-0 2000 Adrenal Androgens and Aging Dehydroepiandrosterone (DHEA) and its active metabolite DHEA sulfate (DHEAS), are steroid hormones synthesized and excreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH). Steroids 110-126 sulfotransferase family 2A member 1 Homo sapiens 98-103 12579657-10 1999 It was also found that the TNF levels in aqueous humor on the 7th and 14th postoperative day were significantly lower (P < 0.05) in the TWP-treated group with IOL implantation than those in the non-treatment group and the steroid-treated group. Steroids 225-232 tumor necrosis factor Oryctolagus cuniculus 27-30 24372086-1 2014 CONTEXT: Classical 3beta-hydroxysteroid dehydrogenase (3beta-HSD) deficiency (3beta-HSDD) is caused by loss-of-function mutations in the HSD3B2 gene encoding type II 3beta-HSD, which has a key role in steroid biosynthesis, converting Delta5-steroids to Delta4-steroids in adrenal glands and gonads. Steroids 32-39 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 55-64 24372086-1 2014 CONTEXT: Classical 3beta-hydroxysteroid dehydrogenase (3beta-HSD) deficiency (3beta-HSDD) is caused by loss-of-function mutations in the HSD3B2 gene encoding type II 3beta-HSD, which has a key role in steroid biosynthesis, converting Delta5-steroids to Delta4-steroids in adrenal glands and gonads. Steroids 241-249 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 55-64 12579657-11 1999 CONCLUSIONS: The current study offers evidence that TWP is more effective than the steroid in reducing the TNF level in aqueous humor after IOL implantation. Steroids 83-90 tumor necrosis factor Oryctolagus cuniculus 107-110 9990042-1 1999 Hsp90, a molecular chaperone required for the functioning of glucocorticosteroid receptor (GR), ensures, by direct interaction, the conformational competence of the steroid-binding pocket. Steroids 73-80 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 9895303-11 1999 The characterization of simian UGT2B20 as a structural and functional homologue of human UGT2B15 further demonstrates the similarities of steroid glucuronidation in these two species, and indicates the relevance of using the monkey as an animal model to study and understand steroid glucuronidation in extrahepatic-steroid target tissues. Steroids 138-145 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 89-96 9895303-11 1999 The characterization of simian UGT2B20 as a structural and functional homologue of human UGT2B15 further demonstrates the similarities of steroid glucuronidation in these two species, and indicates the relevance of using the monkey as an animal model to study and understand steroid glucuronidation in extrahepatic-steroid target tissues. Steroids 275-282 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 89-96 9895303-11 1999 The characterization of simian UGT2B20 as a structural and functional homologue of human UGT2B15 further demonstrates the similarities of steroid glucuronidation in these two species, and indicates the relevance of using the monkey as an animal model to study and understand steroid glucuronidation in extrahepatic-steroid target tissues. Steroids 275-282 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 89-96 10195426-4 1999 Avian erythroid progenitors expressing the EGF receptor/c-ErbB (SCF/TGFalpha progenitors) can be induced to long-term proliferation by the c-ErbB ligand transforming growth factor alpha and the steroids estradiol and dexamethasone. Steroids 194-202 kit ligand Mus musculus 64-67 10024134-0 1999 Preventive effects of insulinlike growth factor-I on steroid-induced muscle atrophy. Steroids 53-60 insulin-like growth factor 1 Rattus norvegicus 22-49 11533945-7 1999 Leptin is released from the adipocytes and may act as a metabolic signal to the hypothalamic areas controlling satiety, energy expenditure, and the regulation of cortisol, insulin, sex steroid and growth hormone release. Steroids 185-192 leptin Homo sapiens 0-6 9886847-0 1999 Induction of thioredoxin, a redox-active protein, by ovarian steroid hormones during growth and differentiation of endometrial stromal cells in vitro. Steroids 61-77 thioredoxin Homo sapiens 13-24 9914473-3 1999 Our previous observations indicate that menstrual endometrial breakdown is initiated by matrix metalloproteinases (MMPs), which are controlled overall by ovarian steroids but are also locally regulated by cytokines. Steroids 162-170 matrix metallopeptidase 1 Homo sapiens 115-119 9920098-3 1999 To examine the regulation of PGDH by steroids and to determine any changes with labor, we obtained placenta and chorion from term elective cesarean section or spontaneous delivery and isolated trophoblast cells using a Percoll density gradient. Steroids 37-45 15-hydroxyprostaglandin dehydrogenase Homo sapiens 29-33 10597896-11 1999 Interactions between Hsp90, histones, and high mobility group (HMG) protein-derived peptides raise the possibility of the involvement of Hsp90 in chromatin reorganization during steroid action, mitosis, or after cellular stress. Steroids 178-185 heat shock protein 90 alpha family class A member 1 Homo sapiens 21-26 10597896-11 1999 Interactions between Hsp90, histones, and high mobility group (HMG) protein-derived peptides raise the possibility of the involvement of Hsp90 in chromatin reorganization during steroid action, mitosis, or after cellular stress. Steroids 178-185 heat shock protein 90 alpha family class A member 1 Homo sapiens 137-142 10099871-8 1998 On the other hand, intraventricular injection of 5 ng of the LH-releasing hormone (LHRH) elevated plasma LH concentrations within 10 min in both groups of rats, but at different efficacy: a brief release of LH in short-term OVX-steroids-primed rats and a prolonged release of LH in long-term OVX-steroids-primed rats. Steroids 228-236 gonadotropin releasing hormone 1 Rattus norvegicus 61-81 10099871-8 1998 On the other hand, intraventricular injection of 5 ng of the LH-releasing hormone (LHRH) elevated plasma LH concentrations within 10 min in both groups of rats, but at different efficacy: a brief release of LH in short-term OVX-steroids-primed rats and a prolonged release of LH in long-term OVX-steroids-primed rats. Steroids 228-236 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 10099871-8 1998 On the other hand, intraventricular injection of 5 ng of the LH-releasing hormone (LHRH) elevated plasma LH concentrations within 10 min in both groups of rats, but at different efficacy: a brief release of LH in short-term OVX-steroids-primed rats and a prolonged release of LH in long-term OVX-steroids-primed rats. Steroids 296-304 gonadotropin releasing hormone 1 Rattus norvegicus 61-81 10099871-8 1998 On the other hand, intraventricular injection of 5 ng of the LH-releasing hormone (LHRH) elevated plasma LH concentrations within 10 min in both groups of rats, but at different efficacy: a brief release of LH in short-term OVX-steroids-primed rats and a prolonged release of LH in long-term OVX-steroids-primed rats. Steroids 296-304 gonadotropin releasing hormone 1 Rattus norvegicus 83-87 10099871-9 1998 These results indicated that the interval after OVX plays a critical role in modulating the responsiveness to NE and LHRH in the steroids-primed OVX rats. Steroids 129-137 gonadotropin releasing hormone 1 Rattus norvegicus 117-121 10221591-7 1998 These studies not only demonstrate that gonadal steroids are capable of regulating beta-catenin mRNA levels in human endometrial stromal cells, but may also give us useful insight into the cellular mechanisms by which gonadal steroids regulate the cyclic remodeling processes that occur in the human endometrium during each menstrual cycle. Steroids 48-56 catenin beta 1 Homo sapiens 83-95 10221591-7 1998 These studies not only demonstrate that gonadal steroids are capable of regulating beta-catenin mRNA levels in human endometrial stromal cells, but may also give us useful insight into the cellular mechanisms by which gonadal steroids regulate the cyclic remodeling processes that occur in the human endometrium during each menstrual cycle. Steroids 226-234 catenin beta 1 Homo sapiens 83-95 9876226-8 1998 Topical steroid treatment was accompanied by a decrease in both the CD3+ and major basic protein (MBP+) cells expressing GM-CSF mRNA (p = 0.01) with a corresponding proportionate increase in the % of macrophages expressing GM-CSF. Steroids 8-15 colony stimulating factor 2 Homo sapiens 121-127 9876226-8 1998 Topical steroid treatment was accompanied by a decrease in both the CD3+ and major basic protein (MBP+) cells expressing GM-CSF mRNA (p = 0.01) with a corresponding proportionate increase in the % of macrophages expressing GM-CSF. Steroids 8-15 colony stimulating factor 2 Homo sapiens 223-229 10485078-13 1998 Our fourth-generation model describes the dose dependence and tolerance effects of TAT mRNA/TAT induction by MPL involving multiple-step signal transduction controlled by the steroid regimen, free GR density, and GR occupancy. Steroids 175-182 tyrosine aminotransferase Rattus norvegicus 83-86 10485078-13 1998 Our fourth-generation model describes the dose dependence and tolerance effects of TAT mRNA/TAT induction by MPL involving multiple-step signal transduction controlled by the steroid regimen, free GR density, and GR occupancy. Steroids 175-182 tyrosine aminotransferase Rattus norvegicus 92-95 10048015-8 1998 CONCLUSIONS: The dramatic improvement occurred under treatment with alglucerase after no response to steroid treatment. Steroids 101-108 glucosylceramidase beta Homo sapiens 68-79 9847114-2 1998 These complexes act to convert steroid hormone receptors to their steroid-binding state by assembling them into heterocomplexes with hsp90, p23, and one of several immunophilins. Steroids 31-38 prostaglandin E synthase 3 Homo sapiens 140-143 9814482-1 1998 CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. Steroids 147-163 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 33-40 9814482-1 1998 CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. Steroids 147-163 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 42-62 9751505-0 1998 DAX-1 blocks steroid production at multiple levels. Steroids 13-20 nuclear receptor subfamily 0, group B, member 1 Mus musculus 0-5 9751505-2 1998 We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Steroids 80-87 nuclear receptor subfamily 0, group B, member 1 Mus musculus 28-33 9751505-2 1998 We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Steroids 80-87 steroidogenic acute regulatory protein Mus musculus 115-119 9751505-2 1998 We have recently shown that DAX-1 can block the first and rate-limiting step in steroid biosynthesis by repressing StAR (steroidogenic acute regulatory protein) expression. Steroids 80-87 steroidogenic acute regulatory protein Mus musculus 121-159 9751505-3 1998 Here we show that DAX-1 blocks steroid production at multiple levels in the Y-1 mouse adrenocortical tumor cell line. Steroids 31-38 nuclear receptor subfamily 0, group B, member 1 Mus musculus 18-23 9867249-0 1998 Influence of cortisol on insulin- and insulin-like growth factor 1 (IGF-1)-induced steroid production and on IGF-1 receptors in cultured bovine granulosa cells and thecal cells. Steroids 83-90 insulin Bos taurus 25-32 9867249-0 1998 Influence of cortisol on insulin- and insulin-like growth factor 1 (IGF-1)-induced steroid production and on IGF-1 receptors in cultured bovine granulosa cells and thecal cells. Steroids 83-90 insulin Bos taurus 38-45 9867249-0 1998 Influence of cortisol on insulin- and insulin-like growth factor 1 (IGF-1)-induced steroid production and on IGF-1 receptors in cultured bovine granulosa cells and thecal cells. Steroids 83-90 insulin like growth factor 1 Bos taurus 68-73 9725824-0 1998 Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Steroids 101-109 leptin Homo sapiens 22-28 9725824-5 1998 Gender differences in leptin disappeared when corrected for sex steroid levels or the combination of adiposity and energy expenditure. Steroids 64-71 leptin Homo sapiens 22-28 9731032-7 1998 GM-CSF expression was significantly increased in bronchial epithelial cells from untreated and steroid-dependent asthmatic patients. Steroids 95-102 colony stimulating factor 2 Homo sapiens 0-6 9710597-6 1998 Overexpression of SNURF in cultured mammalian cells enhanced not only androgen, glucocorticoid, and progesterone receptor-dependent transactivation but also basal transcription from steroid-regulated promoters. Steroids 182-189 SNRPN upstream open reading frame Homo sapiens 18-23 9726841-0 1998 Chemotactic activity and IL-8 levels in the cerebrospinal fluid in canine steroid responsive meningitis-arteriitis. Steroids 74-81 C-X-C motif chemokine ligand 8 Canis lupus familiaris 25-29 9786449-5 1998 The production of activin, which stimulates FSH, and its binding protein follistatin, by pituitary cells raises the possibility that the local production modulates FSH secretion in addition to the long loop feedback signals emanating from the gonads through the steroid hormones estradiol and testosterone as well as circulating inhibin levels. Steroids 262-278 inhibin subunit beta E Homo sapiens 18-25 9713701-2 1998 Both steroids, at 10 microM concentration, increased P4501A1-mediated 7-ethoxyresorufin O-deethyalase activity and amounts of its immunoreactive protein and CYP1A1 mRNA. Steroids 5-13 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 157-163 9656123-7 1998 The transcription factor of steroidogenesis, adrenal 4-binding protein (Ad4BP), was present in nearly all steroid-type stromal cells. Steroids 28-35 nuclear receptor subfamily 5 group A member 1 Homo sapiens 45-70 9656123-7 1998 The transcription factor of steroidogenesis, adrenal 4-binding protein (Ad4BP), was present in nearly all steroid-type stromal cells. Steroids 28-35 nuclear receptor subfamily 5 group A member 1 Homo sapiens 72-77 9656123-8 1998 However, steroidogenic enzymes, 17 alpha-hydroxylase (C17) and 3 beta-hydroxysteroid dehydrogenase (3 beta SD), were expressed only in 10 of 15 cases of histologically identified steroid cells. Steroids 9-16 cytokine like 1 Homo sapiens 54-57 9656123-9 1998 Steroid cells in which Ad4BP but not C17 or 3 beta HSD were expressed were all lutein-type. Steroids 0-7 nuclear receptor subfamily 5 group A member 1 Homo sapiens 23-28 9755461-5 1998 The studies of enzymatic regulation of P450c17 suggest that cytochrome b5 (b5), a heme protein, may switch the reaction of P450c17 by enhancing the 17, 20-lyase activity to increase the level of plasma C19 steroids. Steroids 206-214 cytochrome b5 type A Homo sapiens 60-73 9654650-6 1998 Recently, non-steroidal estrone sulfatase inhibitors have been designed that avoid the problems associated with an active steroid nucleus; however, these have not achieved the potency of estrone-3-O sulfamate. Steroids 14-21 steroid sulfatase Homo sapiens 24-41 24703255-0 2014 The effects of prednisone and steroid-sparing agents on decay accelerating factor (CD55) expression: implications in myasthenia gravis. Steroids 30-37 CD55 molecule, decay accelerating factor for complement Mus musculus 56-81 9787266-1 1998 Previous studies have shown that corticosteroids affect the changes in membrane potential evoked in CA1 hippocampal neurons by serotonin and the metabolically stable cholinergic analogue carbachol: Low corticosteroid levels induced by steroid administration to adrenalectomized rats or obtained in adrenally intact rats were associated with small transmitter responses. Steroids 40-47 carbonic anhydrase 1 Rattus norvegicus 100-103 24347461-0 2014 Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Steroids 40-47 interleukin 17A Homo sapiens 56-62 24564399-7 2014 Expression of 2 other DEHP targets, hormone-sensitive lipase and phosphoenolpyruvate carboxykinase 1 (Pck1), correlated with reduced aldosterone levels and may account for the inhibitory effect of DEHP on adrenal steroid formation. Steroids 213-220 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 65-100 9787266-3 1998 In the present study we investigated the consequences of this steroid modulation for the main stream of synaptic information in the CA1 hippocampal region, which is carried by amino acids. Steroids 62-69 carbonic anhydrase 1 Rattus norvegicus 132-135 24617903-8 2014 Taken together, these data reveal that gonadal steroids influence the pleiotropic actions of OFQ/N on ARH neurones, including POMC neurones, in a disparate manner. Steroids 47-55 proopiomelanocortin Rattus norvegicus 126-130 9674577-1 1998 The number of synapses in the adult, female hippocampal CA1 region fluctuates naturally across the estrous cycle in an ovarian steroid-dependent manner. Steroids 127-134 carbonic anhydrase 1 Rattus norvegicus 56-59 24170211-5 2014 Also, an inverse correlation with steroid hormones (ER and PgR), p27, MDM4, mucin 1 and BRCA1 was observed with PIASgamma expression. Steroids 34-50 protein inhibitor of activated STAT 4 Homo sapiens 112-121 9618522-1 1998 The formation of estrogens from C19 steroids is catalyzed by aromatase cytochrome P450 (P450arom), the product of the cyp19 gene. Steroids 36-44 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 88-96 24474147-7 2014 Anti-inflammatory cytokine IL-10 showed a 6.3-fold increase in the steroid treatment group versus the controls, indicating anti-inflammatory modulation by steroid treatment. Steroids 67-74 interleukin 10 Homo sapiens 27-32 24474147-7 2014 Anti-inflammatory cytokine IL-10 showed a 6.3-fold increase in the steroid treatment group versus the controls, indicating anti-inflammatory modulation by steroid treatment. Steroids 155-162 interleukin 10 Homo sapiens 27-32 24510055-0 2014 Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARgamma expression and activating Wnt signaling pathway. Steroids 21-28 peroxisome proliferator-activated receptor gamma Rattus norvegicus 74-83 9618522-1 1998 The formation of estrogens from C19 steroids is catalyzed by aromatase cytochrome P450 (P450arom), the product of the cyp19 gene. Steroids 36-44 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 118-123 24510055-10 2014 Importantly, pravastatin treatment could prevent steroid-induced ONFH by suppressing the expression of PPARgamma, and increasing the expression of Wnt3a, LRP5, beta-catenin, and RUNX2, at both mRNA and protein levels, in the femoral heads of steroid-induced ONFH rats. Steroids 49-56 peroxisome proliferator-activated receptor gamma Rattus norvegicus 103-112 9622078-11 1998 The steroid form of the UDPGT transcript was expressed in LNCaP cells and was enhanced in biochanin A-treated LNCaP cells. Steroids 4-11 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 24-29 24269740-2 2014 This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are actively involved in the uptake, intracellular transport, and possibly release of steroids from cells. Steroids 233-241 corticosteroid-binding globulin Cricetulus griseus 84-115 24269740-2 2014 This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are actively involved in the uptake, intracellular transport, and possibly release of steroids from cells. Steroids 233-241 corticosteroid-binding globulin Cricetulus griseus 117-120 9677630-11 1998 Steroid therapy diminishes the proteins, GM-CSF.RANTES and IL-8 as well as the messengers IL-4, IL-13 and IL-5. Steroids 0-7 colony stimulating factor 2 Homo sapiens 41-47 9603245-2 1998 These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486. Steroids 18-25 progesterone receptor Rattus norvegicus 79-100 24586766-3 2014 Here we show that the exposure of Fisher 344 rats to mild social stress based on the resident-intruder paradigm increased the expression of 11HSD1 and CYP7B1, an enzyme that catalyzes 7-hydroxylation of steroids. Steroids 203-211 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 151-157 24586974-0 2014 Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy. Steroids 103-110 immunoglobulin heavy constant alpha 1 Homo sapiens 51-55 9603245-2 1998 These actions are steroid specific and dose dependent and are inhibited by the progesterone receptor (PR) antagonist, RU-486. Steroids 18-25 progesterone receptor Rattus norvegicus 102-104 9673774-1 1998 The goals of this study were to determine the steroid-binding specificity of the mouse salivary androgen-binding protein (ABP) family and to ascertain whether there might be other proteins in mouse saliva capable of binding steroids. Steroids 46-53 secretoglobin, family 1B, member 29 Mus musculus 96-120 9673774-1 1998 The goals of this study were to determine the steroid-binding specificity of the mouse salivary androgen-binding protein (ABP) family and to ascertain whether there might be other proteins in mouse saliva capable of binding steroids. Steroids 46-53 secretoglobin, family 1B, member 29 Mus musculus 122-125 24451200-1 2014 Androgen receptor (AR) binds male sex steroids and mediates physiological androgen actions in target tissues. Steroids 38-46 androgen receptor Mus musculus 0-17 9529006-3 1998 Testosterone or estradiol replacement, or administration of GnRH antagonist, totally abolished the effects of castration, demonstrating a mediation of the steroid effects via GnRH. Steroids 155-162 gonadotropin releasing hormone 1 Rattus norvegicus 60-64 24451200-1 2014 Androgen receptor (AR) binds male sex steroids and mediates physiological androgen actions in target tissues. Steroids 38-46 androgen receptor Mus musculus 19-21 24333270-0 2014 Regulation of 3beta-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.). Steroids 138-146 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 14-48 9529006-3 1998 Testosterone or estradiol replacement, or administration of GnRH antagonist, totally abolished the effects of castration, demonstrating a mediation of the steroid effects via GnRH. Steroids 155-162 gonadotropin releasing hormone 1 Rattus norvegicus 175-179 9529006-4 1998 In noncastrated rats, steroids and the GnRH antagonist also caused a reduction in the levels of NOS I (by 50-60%), consistent with inhibition of endogenous GnRH stimulation. Steroids 22-30 gonadotropin releasing hormone 1 Rattus norvegicus 156-160 9529006-8 1998 Taken together, these data demonstrate that steroids indirectly regulate NOS I messenger RNA and protein levels, through the hypothalamic modulation of GnRH, which represents the primary regulator of NOS I. Steroids 44-52 gonadotropin releasing hormone 1 Rattus norvegicus 152-156 9543124-0 1998 The impact of reversible gonadal sex steroid suppression on serum leptin concentrations in children with central precocious puberty. Steroids 37-44 leptin Homo sapiens 66-72 24664559-1 2014 The objectives of this study were to investigate the effects of fibroblast growth factor 9 (FGF9) on hormone-stimulated porcine granulosa cell proliferation and steroid production and to further elucidate the hormonal and developmental control of FGFR2IIIc gene expression in granulosa cells. Steroids 161-168 fibroblast growth factor 9 Homo sapiens 64-90 24664559-1 2014 The objectives of this study were to investigate the effects of fibroblast growth factor 9 (FGF9) on hormone-stimulated porcine granulosa cell proliferation and steroid production and to further elucidate the hormonal and developmental control of FGFR2IIIc gene expression in granulosa cells. Steroids 161-168 fibroblast growth factor 9 Homo sapiens 92-96 25905373-17 2000 VDR acts as a ligand-modulated transcription factor that belongs to the steroid, thyroid, and retinoic acid receptors gene family (10-13). Steroids 72-79 vitamin D receptor Homo sapiens 0-3 9614359-0 1998 Changes in progesterone receptor mRNA content in the rabbit lung during early pregnancy and after sex steroid hormone treatment. Steroids 102-117 progesterone receptor Oryctolagus cuniculus 11-32 25073521-9 2014 Our data demonstrate that testosterone regulates Fmr-1 gene expression in age-dependent manner which may throw light on the mechanisms of age- and sex steroid hormones-dependent alterations in brain function. Steroids 151-167 fragile X messenger ribonucleoprotein 1 Mus musculus 49-54 9614359-7 1998 These findings suggest that PR mRNA content in the rabbit lung is regulated by sex steroid hormones and changes according to the physiological concentrations of oestradiol and progesterone. Steroids 83-99 progesterone receptor Oryctolagus cuniculus 28-30 9699884-4 1998 Recently, we have reported the tissue distribution of UGT2B15, which can conjugate steroids in several human extrahepatic steroid target tissues including the skin, breast and prostate. Steroids 83-91 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 54-61 24601700-8 2014 Patients with steroid-refractory aGvHD received a different second-line therapies (antithymocyte globulin, anti-TNFalpha antibody, anti CD52 antibody) with response rate 45 % (CR - 18 %, PR - 27 %). Steroids 14-21 CD52 molecule Homo sapiens 136-140 9699884-4 1998 Recently, we have reported the tissue distribution of UGT2B15, which can conjugate steroids in several human extrahepatic steroid target tissues including the skin, breast and prostate. Steroids 83-90 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 54-61 9699884-6 1998 UGT2B17 is also widely distributed in several human steroid target tissues. Steroids 52-59 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9699884-14 1998 In addition, UGT2B17 was shown to be more labile than UGT2B15 indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 176-184 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 13-20 9699884-14 1998 In addition, UGT2B17 was shown to be more labile than UGT2B15 indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 176-184 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 54-61 24168365-7 2014 Within the spectrum of major mitochondrial structural components, the 18 kDa translocator protein (TSPO) has shown important and relevant functions such as steroid synthesis and modulation of the mitochondrial permeability transition that may substantially affect the fate of injured cells. Steroids 156-163 translocator protein Homo sapiens 99-103 9699884-14 1998 In addition, UGT2B17 was shown to be more labile than UGT2B15 indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 176-184 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 92-99 9506940-4 1998 The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone. Steroids 41-56 nuclear receptor coactivator 1 Mus musculus 26-31 24290279-11 2014 CONCLUSION: BATF is increased in non-steroid-treated asthmatic children. Steroids 37-44 basic leucine zipper ATF-like transcription factor Homo sapiens 12-16 25007867-0 2014 REV-ERBalpha inhibits the PTGS2 expression in bovine uterus endometrium stromal and epithelial cells exposed to ovarian steroids. Steroids 120-128 prostaglandin-endoperoxide synthase 2 Bos taurus 26-31 9546661-3 1998 Here we provide evidence that in a reciprocal experiment, CYP11B2-specific amino acids at position 320 and 335 endowed CYP11B1 with an 18-oxidase function amounting to 20% of the CYP11B2 wild-type activity, thus changing the specificity of steroid hydroxylation by only one point mutation. Steroids 240-247 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 58-65 26096867-0 2016 Urine Neutrophil Gelatinase Associated Lipocalin to Creatinine Ratio: A Novel Index for Steroid Response in Idiopathic Nephrotic Syndrome. Steroids 88-95 lipocalin 2 Homo sapiens 6-48 26096867-1 2016 OBJECTIVE: To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS). Steroids 107-114 lipocalin 2 Homo sapiens 38-80 26096867-1 2016 OBJECTIVE: To find the value of urine neutrophil gelatinase associated lipocalin (NGAL) in differentiating steroid response in children with idiopathic nephrotic syndrome (INS). Steroids 107-114 lipocalin 2 Homo sapiens 82-86 26096867-4 2016 RESULTS: Serum creatinine (P 0.032), and urine NGAL/Cr (P 0.001) were significantly higher in steroid resistant than steroid sensitive patients. Steroids 94-101 lipocalin 2 Homo sapiens 47-51 23943159-9 2013 There is also evidence for the presence of several receptors on integrin alphavbeta3 for authentic steroids, including a dihydrotestosterone site that supports proliferation of breast cancer cells that lack nuclear androgen and estrogen receptors. Steroids 99-107 integrin subunit alpha V Homo sapiens 64-84 9546661-3 1998 Here we provide evidence that in a reciprocal experiment, CYP11B2-specific amino acids at position 320 and 335 endowed CYP11B1 with an 18-oxidase function amounting to 20% of the CYP11B2 wild-type activity, thus changing the specificity of steroid hydroxylation by only one point mutation. Steroids 240-247 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 179-186 26096867-6 2016 CONCLUSIONS: Urine NGAL/Cr could be considered as a marker of steroid resistance in children with idiopathic nephrotic syndrome. Steroids 62-69 lipocalin 2 Homo sapiens 19-23 9635147-4 1998 These findings indicate that relatively minor modifications in the chemical structure of classical steroid sulfamates can preserve or enhance their estrone sulfatase inhibiting properties and, simultaneously, amplify their antioxidant capacity to a great extent. Steroids 99-106 steroid sulfatase Homo sapiens 148-165 26385605-10 2016 This study reveals that the androgen-inactivating UGT2B15 and UGT2B17 genes are direct targets of miR-376c and thus may influence steroid metabolism during prostate cancer progression. Steroids 130-137 microRNA 376c Homo sapiens 98-106 26654513-10 2016 DISCUSSION: Placental steroid metabolism of human and rat shows relevant species-specific differences, especially regarding the barrier function of 11beta-HSD2 at term. Steroids 22-29 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 148-159 23279563-4 2013 We hypothesized that steroid hormone treatments (E2 and P4 ) of bovine mammary epithelial cells in vitro would induce up-regulation of IgG1 transcytosis candidate gene mRNA expression suggesting involvement in IgG1 transcytosis. Steroids 21-36 dihydrolipoamide S-succinyltransferase Bos taurus 49-58 24057187-1 2013 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. Steroids 129-137 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 33-64 9513083-9 1998 The results indicate that in both male and female mice, 17HSD type 2 is expressed mainly in the various epithelial cell types of the gastrointestinal and urinary tracts, and therefore suggest a role for the enzyme in steroid inactivation in a range of tissues and cell types not considered as classical sex steroid target tissues. Steroids 217-224 hydroxysteroid (17-beta) dehydrogenase 2 Mus musculus 56-68 24057187-1 2013 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. Steroids 129-137 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 66-72 24057187-1 2013 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. Steroids 129-136 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 33-64 24057187-1 2013 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is an important metabolic process during which steroids are converted to more easily excreted compounds in steroid target tissues, such as the prostate. Steroids 129-136 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 66-72 9513083-9 1998 The results indicate that in both male and female mice, 17HSD type 2 is expressed mainly in the various epithelial cell types of the gastrointestinal and urinary tracts, and therefore suggest a role for the enzyme in steroid inactivation in a range of tissues and cell types not considered as classical sex steroid target tissues. Steroids 307-314 hydroxysteroid (17-beta) dehydrogenase 2 Mus musculus 56-68 26409663-0 2015 Claudin 5 in a murine model of allergic asthma: Its implication and response to steroid treatment. Steroids 80-87 claudin 5 Mus musculus 0-9 9605549-0 1998 Engineering the steroid-specificity of an anti-17beta-estradiol Fab by random mutagenesis and competitive phage panning. Steroids 16-23 FA complementation group B Homo sapiens 64-67 23811617-9 2013 CONCLUSIONS: Although both US-guided and blind steroid injections were effective in reducing the symptoms of CTS and improving the function, an earlier onset/better improvement of symptom relief suggests that US-guided steroid injection may be more effective than are blind injections in CTS. Steroids 47-54 transthyretin Homo sapiens 109-112 23811617-9 2013 CONCLUSIONS: Although both US-guided and blind steroid injections were effective in reducing the symptoms of CTS and improving the function, an earlier onset/better improvement of symptom relief suggests that US-guided steroid injection may be more effective than are blind injections in CTS. Steroids 219-226 transthyretin Homo sapiens 288-291 25246106-2 2015 Klotho protein is a beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. Steroids 62-69 klotho Homo sapiens 0-6 9605549-1 1998 We have employed random mutagenesis and phage display to improve the steroid-specificity of an anti-17beta-estradiol Fab fragment. Steroids 69-76 FA complementation group B Homo sapiens 117-120 9497103-4 1998 In this context, we investigated the regulation of the human LIF promoter (human LIF666-luciferase) by ovarian steroids in transient transfection assays in MDA-MB 231 and T47D cells. Steroids 111-119 LIF interleukin 6 family cytokine Homo sapiens 61-64 26758116-11 2015 (3) In steroid group, IL-2 and IL-8 in BALF of patient whose fever disappeared after steroid therapy were both significantly lower than that of patients who still had fever (t=2.771, 2.054, P=0.010, 0.049) , but no significant difference was found between the two groups in BALF IL-1 beta, IL-4, IL-6, IL-10, IFN-gamma levels (P>0.05). Steroids 7-14 interleukin 10 Homo sapiens 302-307 24022868-2 2013 The adrenal sex steroid precursor dehydroepiandrosterone (DHEA) has been shown to inhibit 11beta-HSD1 in murine adipocytes; however, rodent adrenals do not produce DHEA physiologically. Steroids 16-23 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 90-101 24413855-1 2013 BACKGROUND AND OBJECTIVES: Mutations in several genes are known to cause steroid-resistant nephrotic syndome (SRNS), most commonly in NPHS1, NPHS2, and WT1. Steroids 73-80 NPHS1 adhesion molecule, nephrin Homo sapiens 134-139 9568807-17 1998 It is concluded that (1) the CNS maturational events which change the regulation of serum IGF-1 and IGFBP-3 are induced by the pubertal increase in sex steroids in a nonreversible way and (2) the high adrenal steroid levels present in CAH induce a nonreversible activation of the GH-IGF-1 axis and of the GnRH pulse generator. Steroids 152-160 insulin like growth factor binding protein 3 Homo sapiens 100-107 23994167-10 2013 The results suggest that 3HBD is an NADPH-preferring reductase, and plays roles in the metabolisms of steroids, prostaglandin D2, carbohydrates and xenobiotics, as well as a defense system, protecting against reactive carbonyl compounds. Steroids 102-110 prostaglandin-E(2) 9-reductase-like Oryctolagus cuniculus 25-29 26356576-8 2015 For the global perfusion, DHEAS was the only significant predictor amongst the steroid hormones, showing a strong negative correlation with cerebral perfusion. Steroids 79-86 sulfotransferase family 2A member 1 Homo sapiens 26-31 9568807-17 1998 It is concluded that (1) the CNS maturational events which change the regulation of serum IGF-1 and IGFBP-3 are induced by the pubertal increase in sex steroids in a nonreversible way and (2) the high adrenal steroid levels present in CAH induce a nonreversible activation of the GH-IGF-1 axis and of the GnRH pulse generator. Steroids 152-159 insulin like growth factor binding protein 3 Homo sapiens 100-107 9453000-5 1998 The addition of 30 nM DHT to the steroid-free medium resulted in a slight increase in Gus and in a more marked increase in KAP transcripts in both cell lines. Steroids 33-40 glucuronidase, beta Mus musculus 86-89 26061725-2 2015 Kisspeptin/neurokinin B/dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in steroid feedback control of GnRH secretion, and prenatal T treatment in sheep causes an imbalance of KNDy peptide expression within the ARC. Steroids 97-104 tachykinin-3 Ovis aries 11-23 24025090-3 2013 In addition to xenobiotics, endogenous compounds such as steroid hormones and bile acids can also activate PXR and/or CAR. Steroids 57-73 nuclear receptor subfamily 1 group I member 3 Homo sapiens 118-121 9415568-6 1997 A reduced fibrinolytic potential (significant prolongation of lysis time) due to a significant increase in PAI-1 activity and antigen levels was found in heart transplant patients treated with steroids, as compared with patients without steroid treatment and control subjects. Steroids 193-201 serpin family E member 1 Homo sapiens 107-112 24021943-9 2013 Targeting CD137 reduces pro-inflammatory/cytotoxic expression in steroid-resistant CD28null T and NKT-like cells and may have therapeutic implications for patients with BOS. Steroids 65-72 TNF receptor superfamily member 9 Homo sapiens 10-15 26076042-2 2015 In rodents, estrogen-sensitive kisspeptin neurons in the anterior ventral periventricular nucleus and neighboring periventricular nucleus are thought to mediate sex steroid-induced positive feedback induction of the preovulatory LH surge. Steroids 165-172 KiSS-1 metastasis-suppressor Mus musculus 31-41 9415568-6 1997 A reduced fibrinolytic potential (significant prolongation of lysis time) due to a significant increase in PAI-1 activity and antigen levels was found in heart transplant patients treated with steroids, as compared with patients without steroid treatment and control subjects. Steroids 193-200 serpin family E member 1 Homo sapiens 107-112 25936508-5 2015 Previous investigations from our laboratory identified additional ligands targeted to TSPO"s CRAC motif which are able to potently inhibit mitochondrial cholesterol transport and steroid biosynthesis, processes for which TSPO has been well-characterized. Steroids 179-186 translocator protein Homo sapiens 86-90 25936508-5 2015 Previous investigations from our laboratory identified additional ligands targeted to TSPO"s CRAC motif which are able to potently inhibit mitochondrial cholesterol transport and steroid biosynthesis, processes for which TSPO has been well-characterized. Steroids 179-186 translocator protein Homo sapiens 221-225 23946277-2 2013 Recently, somatic KCNJ5 K(+)-channel mutations in aldosterone-producing adenoma (APA) patients have been shown to influence steroid gradients during AVS. Steroids 124-131 potassium inwardly rectifying channel subfamily J member 5 Homo sapiens 18-23 9428674-3 1997 207, 69-73] demonstrated two conformations (A and B) of cytochrome P-450scc (SCC), the enzyme which initiates steroid biosynthesis by cleaving the side chain of cholesterol. Steroids 110-117 serpin family B member 3 Homo sapiens 77-80 24347943-1 2013 BACKGROUND: Local steroid injection is one of the treatment modalities for carpal tunnel syndrome (CTS). Steroids 18-25 transthyretin Homo sapiens 99-102 24347943-16 2013 CONCLUSION: One month after local steroid injection among the electrophysiological parameters studied distal motor latencies showed most consistent and recordable improvement across the severity spectrum of CTS. Steroids 34-41 transthyretin Homo sapiens 207-210 9364061-2 1997 In rodents, this facilitatory effect requires previous exposure to estradiol, suggesting that the steroid affects downstream components in the cascade that leads to PGE2-induced LHRH release. Steroids 98-105 gonadotropin releasing hormone 1 Mus musculus 178-182 23751811-1 2013 Dehydroepiandrosterone (DHEA) and its sulfate, DHEAS, are the most abundant steroid hormones in primates, providing a large reservoir of precursors for the production of androgens. Steroids 76-92 sulfotransferase family 2A member 1 Homo sapiens 47-52 25706901-1 2015 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) are the most abundant circulating adrenal steroid hormones. Steroids 116-132 sulfotransferase family 2A member 1 Homo sapiens 67-72 9400025-9 1997 These results indicate that although hepatic CYP2C11 is regulated by GH, rat renal CYP2C11 is regulated primarily by gonadal steroids. Steroids 125-133 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 83-90 26092996-9 2015 Importantly, transfection of cells with siRNA-STAT1 was able to restore steroid responsiveness of GC-insensitive IIGs. Steroids 72-79 signal transducer and activator of transcription 1 Homo sapiens 46-51 24002028-2 2013 3beta-HSD is often associated with steroidogenesis, but its function in the metabolism of both steroids and xenobiotics is more obscure. Steroids 95-103 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 0-9 24002028-6 2013 3beta-HSD is involved in the synthesis of a number of natural steroid hormones, including progesterone and testosterone, and the hepatic degradation of the pheromone androstenone. Steroids 62-78 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 0-9 24002028-9 2013 Much of the research conducted on porcine 3beta-HSD is motivated by its importance for the occurrence of the boar taint phenomenon that results from high concentrations of steroids such as androstenone. Steroids 172-180 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 42-51 9383281-1 1997 11 beta-hydroxylase (Cyp11b1) mutations were previously linked to altered steroid biosynthesis and blood pressure in Dahl salt-resistant (R) and Dahl salt-sensitive (S) rats. Steroids 74-81 cytochrome P450, family 11, subfamily b, polypeptide 1 Rattus norvegicus 21-28 25985248-7 2015 The cumulative probability of colectomy tended to be lower in complete responders on day 7 of intravenous steroid therapy (CR7) than in others: 3.7% versus 13.9% at 5 years and 7.6% versus 18.2% at 10 years (P = 0.100). Steroids 106-113 teratocarcinoma-derived growth factor 1 pseudogene 7 Homo sapiens 123-126 9348209-0 1997 Corticotropin-releasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1 receptor-mediated fashion. Steroids 47-54 corticotropin releasing hormone Homo sapiens 0-31 26483966-1 2015 The translocator protein (TSPO) promotes the translocation of cholesterol to the inner mitochondrial membrane and mediates steroid formation. Steroids 123-130 translocator protein Homo sapiens 4-24 26483966-1 2015 The translocator protein (TSPO) promotes the translocation of cholesterol to the inner mitochondrial membrane and mediates steroid formation. Steroids 123-130 translocator protein Homo sapiens 26-30 9348209-0 1997 Corticotropin-releasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1 receptor-mediated fashion. Steroids 47-54 corticotropin releasing hormone Homo sapiens 33-36 9348209-0 1997 Corticotropin-releasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1 receptor-mediated fashion. Steroids 47-54 corticotropin releasing hormone Homo sapiens 114-117 23770611-1 2013 Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions including puberty, sex steroid feedback, and overall fertility. Steroids 117-124 KiSS-1 metastasis-suppressor Mus musculus 0-10 9373855-0 1997 Steroid-level response to insulin-like growth factor-1 in oocytes matured in vitro. Steroids 0-7 insulin-like growth factor I Oryctolagus cuniculus 26-54 23770611-1 2013 Kisspeptin signaling through its receptor, Kiss1R, is crucial for many reproductive functions including puberty, sex steroid feedback, and overall fertility. Steroids 117-124 KISS1 receptor Mus musculus 43-49 26071814-7 2015 The CYP18A1 gene that participates in steroid hormone inactivation and the CYP15C1 gene that participates in the epoxidation during the synthesis of juvenile hormone (JH) from methyl farnesoate (MF) were increased by 3.85- and 7.82-fold, respectively. Steroids 38-45 cytochrome P450 18a1 Bombyx mori 4-11 23851904-7 2013 Administration of the CYP3A4 inducer rifampicin produced distinct differences in CYP3A4 and CYP11B1, CYP19A1, HSD11B, and HSD17B, which were indicated by their heat map-visualized steroid signatures. Steroids 180-187 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 92-99 9373855-1 1997 The objective was to establish the influence of insulin-like growth factor-1 (IGF-1) on steroid production and nuclear maturation during oocyte in vitro maturation (IVM). Steroids 88-95 insulin-like growth factor I Oryctolagus cuniculus 48-76 23851904-8 2013 CONCLUSIONS: This CYP-mediated steroid signature profile allows simultaneous assessment of CYP1A, CYP1B, CYP2C, CYP3A, CYP11B, CYP17A, CYP19A, and CYP21A in urine samples. Steroids 31-38 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 105-110 25463758-2 2015 Although SF-1 was identified as a transcriptional regulator for steroid metabolic enzymes, it has been shown that SF-1 also regulates other genes that are involved in various cellular processes. Steroids 64-71 splicing factor 1 Homo sapiens 9-13 9373855-1 1997 The objective was to establish the influence of insulin-like growth factor-1 (IGF-1) on steroid production and nuclear maturation during oocyte in vitro maturation (IVM). Steroids 88-95 insulin-like growth factor I Oryctolagus cuniculus 78-83 25617485-3 2015 Of these steroids, E1 presents with lower estrogenic activity, but is converted to highly active E2 by HSD17B1. Steroids 9-17 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 103-110 23851904-8 2013 CONCLUSIONS: This CYP-mediated steroid signature profile allows simultaneous assessment of CYP1A, CYP1B, CYP2C, CYP3A, CYP11B, CYP17A, CYP19A, and CYP21A in urine samples. Steroids 31-38 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 119-125 9406847-10 1997 We conclude that the expression pattern of 17HSD type 2 in the developing placenta and fetus suggests a role for the enzyme in maintaining a barrier to the transfer of active 17-hydroxy forms of sex steroids between the fetus and maternal circulation. Steroids 199-207 hydroxysteroid (17-beta) dehydrogenase 2 Mus musculus 43-55 23894377-7 2013 Pathway analysis suggests a model in which down regulation of the nuclear transcription factors HNF4alpha and PPARalpha in both BAT and liver may orchestrate the down regulation of genes involved in lipoprotein and steroid metabolism as well as Phase I enzymes belonging to the cytochrome P450 group in response to cold stress in mice. Steroids 215-222 hepatic nuclear factor 4, alpha Mus musculus 96-105 9372229-0 1997 Luteinizing hormone-releasing hormone gene expression differs in young and middle-aged females on the day of a steroid-induced LH surge. Steroids 111-118 gonadotropin releasing hormone 1 Rattus norvegicus 0-37 23847592-2 2013 Conjugation of anabolic steroids during phase II metabolism, mainly driven by UDP-glucuronosyltransferase (UGT) 2B7, 2B15, and 2B17, has been shown to be impaired in vitro by a range of compounds including xenobiotics and pharmaceuticals. Steroids 24-32 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 78-121 25650123-5 2015 Therefore, the aim of the study was to assess the amount and activity of MMP-9 in context of pro-inflammatory cytokines (IL-6, IL-8 and tumor necrosis factor, TNF), measured in EBC of asthma-suffering children, treated with inhaled steroids. Steroids 232-240 matrix metallopeptidase 9 Homo sapiens 73-78 25650123-8 2015 Despite chronic treatment with inhaled steroids mean MMP-9/EBC activity in asthma group was significantly higher than in healthy controls. Steroids 39-47 matrix metallopeptidase 9 Homo sapiens 53-58 9342005-1 1997 We previously found that prostate-specific antigen (PSA) expression in the female breast is regulated by steroid hormones and their receptors. Steroids 105-112 kallikrein related peptidase 3 Homo sapiens 25-56 25970467-5 2015 Microarray expression profiling of normal versus starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction. Steroids 191-198 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 127-133 25970467-5 2015 Microarray expression profiling of normal versus starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, DUSP10 and FREM2 are involved in signal transduction. Steroids 191-198 FRAS1 related extracellular matrix 2 Homo sapiens 258-263 23329699-5 2013 In patients with longitudinally extensive transverse myelitis, positive AQP4-Ab assay results were associated with the poor response to acute steroid treatment and asymptomatic visual evoked potential abnormality. Steroids 142-149 aquaporin 4 Homo sapiens 72-76 23895838-0 2013 [Effects of gastrin on rat intestinal epithelial 1,25(OH)2D3-membrane associated rapid response steroid binding protein]. Steroids 96-103 gastrin Rattus norvegicus 12-19 9364925-0 1997 Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme. Steroids 88-95 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 59-66 23895838-1 2013 OBJECTIVE: To explore the effects of gastrin on the expression of 1,25(OH)2D3-membrane associated rapid response steroid (1,25D3-MARRS) binding protein in rat intestinal epithelium. Steroids 113-120 gastrin Rattus norvegicus 37-44 25628335-5 2015 In mammals, adrenodoxin, the ferredoxin FDX1, is an Fe-S-containing protein essential for the synthesis of various steroid hormones. Steroids 115-122 ferredoxin 1 Homo sapiens 40-44 9364925-1 1997 UGT2B17 is a UDP-glucuronosyltransferase enzyme expressed in several extrahepatic steroid target tissues, including the human prostate, where it glucuronidates C19 steroids such as dihydrotestosterone (DHT), androsterone (ADT), and androstane-3alpha, 17beta-diol (3alpha-diol). Steroids 82-89 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9364925-10 1997 This study demonstrates regulation of the UGT2B17 gene by physiological effectors of the human prostate and supports the hypothesis that UGT enzymes are involved in steroid metabolism in extrahepatic tissues. Steroids 165-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 42-49 9329351-3 1997 This prompted us to study prospectively the effects of cross-sex steroid hormones on serum leptin levels in 17 male to female transsexuals and 15 female to male transsexuals. Steroids 65-81 leptin Homo sapiens 91-97 25821913-3 2015 We found that a primary effect of gonadal steroids in the highly sexually dimorphic preoptic area (POA) is to reduce activity of DNA methyltransferase (Dnmt) enzymes, thereby decreasing DNA methylation and releasing masculinizing genes from epigenetic repression. Steroids 42-50 DNA methyltransferase 1 Homo sapiens 129-150 25821913-3 2015 We found that a primary effect of gonadal steroids in the highly sexually dimorphic preoptic area (POA) is to reduce activity of DNA methyltransferase (Dnmt) enzymes, thereby decreasing DNA methylation and releasing masculinizing genes from epigenetic repression. Steroids 42-50 DNA methyltransferase 1 Homo sapiens 152-156 25661194-11 2015 CONCLUSIONS: Steroid therapy in INS induces decreased P-gp expression on PBLs along with increased frequency and cytokine response of T-regulatory cells, and reduced frequency and respective cytokine response of Th1 and Th2 cells during remission. Steroids 13-20 negative elongation factor complex member C/D Homo sapiens 212-215 23704104-1 2013 BACKGROUND AND PURPOSE: Previous research suggests greater risk of coronary heart disease with lower levels of the adrenal steroid dehydroepiandrosterone sulfate (DHEAS). Steroids 123-130 sulfotransferase family 2A member 1 Homo sapiens 163-168 23690474-8 2013 Although expression of nutrient transporters on CF blood or airway neutrophils was not altered by genotype, age, gender, or Pseudomonas aeruginosa infection, oral steroid treatment decreased Glut1 and PiT2 levels in blood neutrophils. Steroids 163-170 solute carrier family 2 member 1 Homo sapiens 191-196 9329351-11 1997 In conclusion, these results indicate that sex steroid hormones, in particular testosterone, play an important role in the regulation of serum leptin levels. Steroids 47-63 leptin Homo sapiens 143-149 9329351-12 1997 The prevailing sex steroid milieu, not genetic sex, is a significant determinant of the sex difference in serum leptin levels. Steroids 19-26 leptin Homo sapiens 112-118 23246844-8 2013 Building on these new data, we propose a novel model for the interactions of this steroid and neurotrophin, whereby rapid, non-genomic 17beta-estradiol and acute BDNF signal in a co-operative manner, resulting in dendritic spine formation and subsequent stabilization in support of synapse and circuit plasticity. Steroids 82-89 brain derived neurotrophic factor Homo sapiens 162-166 9329839-8 1997 Accordingly, during steroid-induced in vitro DZ, a marked increase in the expression of stromal cell TF and PAI-1 and reciprocal inhibition of tPA activity suggest mechanisms to account for the absence of hemorrhage during invasion of the endometrial vasculature by implanting trophoblasts. Steroids 20-27 serpin family E member 1 Homo sapiens 108-113 23525219-0 2013 Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells. Steroids 73-80 translocator protein Rattus norvegicus 34-54 23525219-0 2013 Drug ligand-induced activation of translocator protein (TSPO) stimulates steroid production by aged brown Norway rat Leydig cells. Steroids 73-80 translocator protein Rattus norvegicus 56-60 23525219-1 2013 Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation. Steroids 209-216 translocator protein Rattus norvegicus 0-20 23525219-1 2013 Translocator protein (TSPO; 18 kDA) is a high-affinity cholesterol-binding protein that is integrally involved in cholesterol transfer from intracellular stores into mitochondria, the rate-determining step in steroid formation. Steroids 209-216 translocator protein Rattus norvegicus 22-26 9324051-3 1997 In cyclic rats and steroid-treated ovariectomized rats, RXR alpha and RAR gamma were detected in basal and suprabasal cells while RAR alpha was mainly localized in suprabasal cells. Steroids 19-26 retinoic acid receptor, alpha Rattus norvegicus 130-139 23225066-10 2013 Our data show, that endometrial LRP1 protein expression was specifically high in such cyclic and pregnancy stages which have a high tissue remodelling activity in dependence of differing steroid hormone concentrations. Steroids 187-202 LRP1 Sus scrofa 32-36 9298893-0 1997 BRI-ghtening the pathway to steroid hormone signaling events in plants. Steroids 28-43 integral membrane protein 2B Homo sapiens 0-3 23529131-3 2013 The steroid hormone oestrogen (17beta-oestradiol; E2), produces a female-specific antisecretory response in rat distal colon through the inhibition of the KCNQ1:KCNE3 channel. Steroids 4-19 potassium voltage-gated channel subfamily E regulatory subunit 3 Rattus norvegicus 161-166 23548611-9 2013 The sex steroid hormone-related changes in hepatic Cyp2e1 expression were highly correlated with those observed in Hnf-1alpha, beta-catenin, and Srebp-1c. Steroids 8-23 catenin (cadherin associated protein), beta 1 Mus musculus 127-139 9282989-6 1997 These results indicate that the observed increase in steroid production in response to CRH in MA-10 Leydig tumor cells is similar to that previously seen with trophic hormone stimulation acting through the cAMP second messenger pathway, and that it occurs as a result of an increase in the synthesis of the StAR protein. Steroids 53-60 steroidogenic acute regulatory protein Mus musculus 307-311 23435367-7 2013 These results indicate transcription of FDX1 is regulated by the NR5A family and cAMP signaling, and participates in steroid hormone production in ovarian granulosa cells. Steroids 117-132 ferredoxin 1 Homo sapiens 40-44 9275063-0 1997 Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. Steroids 0-7 kallikrein related peptidase 3 Homo sapiens 96-165 9275063-1 1997 We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Steroids 21-28 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Homo sapiens 92-96 23656401-0 2013 Type 1/type 2 cytokine serum levels and role of interleukin-18 in children with steroid-sensitive nephrotic syndrome. Steroids 80-87 interleukin 18 Homo sapiens 48-62 9275063-1 1997 We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Steroids 21-28 kallikrein related peptidase 3 Homo sapiens 126-130 9275063-6 1997 Glucocorticoid was the most powerful activator of the hPSA construct at 10-nM steroid concentrations. Steroids 78-85 kallikrein related peptidase 3 Homo sapiens 54-58 9275063-8 1997 The results indicate that the steroid response elements in the proximal promoters of hPSA and hK2 genes are not androgen specific, offering the molecular basis for the expression of these genes outside the prostate in tissues containing steroid receptors. Steroids 30-37 kallikrein related peptidase 3 Homo sapiens 85-89 9275065-8 1997 Characterization of the interplay between these hormone receptors on the LDLR in vitro system may allow a better understanding of the actions of sex steroids on LDLR gene expression and their roles in cardiovascular disease. Steroids 149-157 low density lipoprotein receptor Homo sapiens 73-77 23626400-1 2013 The purpose of this investigation was to design novel pentablock copolymers (polylatide-polycaprolactone-polyethylene glycol- polycaprolactone-polylatide) (PLA-PCL-PEG-PCL-PLA) to prepare nanoparticle formulations which provide continuous delivery of steroids over a longer duration with minimal burst effect. Steroids 251-259 PHD finger protein 1 Homo sapiens 160-163 9275065-8 1997 Characterization of the interplay between these hormone receptors on the LDLR in vitro system may allow a better understanding of the actions of sex steroids on LDLR gene expression and their roles in cardiovascular disease. Steroids 149-157 low density lipoprotein receptor Homo sapiens 161-165 9379119-1 1997 During pubertal maturation, the increase in blood concentrations of sexual steroids is associated with a spurt in plasma IGF-I in primates, rats and cattle. Steroids 75-83 insulin-like growth factor 1 Rattus norvegicus 121-126 23638491-0 2004 N-(6-[(18)F]Fluoro-4-phenoxypyridin-3-yl)-N-(2-methoxybenzyl)acetamide The 18-kDa translocator protein (TSPO; also known as the peripheral benzodiazepine receptor (PBR)) is evolutionarily conserved and is found mainly in the outer membrane of the mitochondria of steroid-synthesizing tissues, including the brain (1). Steroids 263-270 translocator protein Rattus norvegicus 104-108 23638491-1 2004 Although the TSPO is involved in neuroinflammation and axonal regeneration after brain injury (2), the best characterized function of this protein is the transport of cholesterol from the outer membrane of the mitochondria to the inner membrane of these organelles, where it is used for steroid and neurosteroid hormone synthesis (2). Steroids 287-294 translocator protein Rattus norvegicus 13-17 9379324-12 1997 EGF and IL-1 present in inflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic pathway. Steroids 107-114 epidermal growth factor Homo sapiens 0-3 23313282-10 2013 Based on the proteomic analysis, several proteins related to vasospasm, such as fibrinogen, thrombin, and apolipoprotein E, were identified in rabbits with osteonecrosis soon after steroid administration. Steroids 181-188 prothrombin Oryctolagus cuniculus 92-100 9379324-12 1997 EGF and IL-1 present in inflammatory exudate may have implications on phenytoin-induced overgrowth via the steroid metabolic pathway. Steroids 107-114 interleukin 1 alpha Homo sapiens 8-12 9449213-0 1997 Effects of recombinant murine leptin on steroid secretion of dispersed rat adrenocortical cells. Steroids 40-47 leptin Mus musculus 30-36 23506901-0 2013 The heteromeric organic solute transporter, OSTalpha-OSTbeta/SLC51: a transporter for steroid-derived molecules. Steroids 86-93 solute carrier family 51, alpha subunit Mus musculus 44-52 23506901-7 2013 Overall, characterization of the transporter"s substrate specificity, transport mechanism, tissue distribution, subcellular localization, and transcriptional regulation as well as the phenotype of the recently generated Slc51a-deficient mice have revealed that OSTalpha-OSTbeta plays a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. Steroids 342-350 solute carrier family 51, alpha subunit Mus musculus 220-226 23506901-7 2013 Overall, characterization of the transporter"s substrate specificity, transport mechanism, tissue distribution, subcellular localization, and transcriptional regulation as well as the phenotype of the recently generated Slc51a-deficient mice have revealed that OSTalpha-OSTbeta plays a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. Steroids 342-350 solute carrier family 51, alpha subunit Mus musculus 261-269 23178794-6 2013 RESULTS: TGF-beta1, p-Smad2, IL-10, SOCS3, and Foxp3 expression was higher in steroid-treated NP patients than in untreated NP patients. Steroids 78-85 interleukin 10 Homo sapiens 29-34 9322226-7 1997 The present observations suggest that gonadal steroids might influence LHRH release acting directly on the cells which manufacture and release the hypothalamic hormone. Steroids 46-54 gonadotropin releasing hormone 1 Mus musculus 71-75 23631257-5 2013 Studies revealed that optic neuritis associated with anti-aquaporin(AQP) 4 antibodies is refractory to steroid therapy and causes injuries to the optic nerve-optic chiasma-optic tract, resulting in a broad array of visual field abnormalities. Steroids 103-110 aquaporin 4 Homo sapiens 68-74 9442573-9 1997 Medium samples were obtained after oocyte maturation in vitro for 16 h. Use of IGF-I significantly elevated steroids production in the oocyte surrounded cumulus cells. Steroids 108-116 insulin-like growth factor I Oryctolagus cuniculus 79-84 23507054-8 2013 We recommend especially to monitor neutrophiles, lymphocytes and if needed CD3-, CD4- and CD8-cell counts in patients receiving steroids and cyclophosphamide or other cytotoxic agents. Steroids 128-136 CD8a molecule Homo sapiens 90-93 23160983-0 2013 Glucocorticoid receptor-beta up-regulation and steroid resistance induction by IL-17 and IL-23 cytokine stimulation in peripheral mononuclear cells. Steroids 47-54 interleukin 17A Homo sapiens 79-84 9261129-7 1997 We have shown that hsp90, p60, and hsp70 are sufficient for carrying out the folding change that converts the glucocorticoid receptor (GR) hormone binding domain (HBD) from a non-steroid binding to a steroid binding conformation, but to form stable GR.hsp90 heterocomplexes, p23 must also be present in the incubation mix (Dittmar, K. D., and Pratt, W. B. Steroids 179-186 heat shock protein 90 alpha family class A member 1 Homo sapiens 19-24 9261129-7 1997 We have shown that hsp90, p60, and hsp70 are sufficient for carrying out the folding change that converts the glucocorticoid receptor (GR) hormone binding domain (HBD) from a non-steroid binding to a steroid binding conformation, but to form stable GR.hsp90 heterocomplexes, p23 must also be present in the incubation mix (Dittmar, K. D., and Pratt, W. B. Steroids 179-186 stress induced phosphoprotein 1 Homo sapiens 26-29 9296373-0 1997 Specific modulation of estrogen receptor mRNA isoforms in rat pituitary throughout the estrous cycle and in response to steroid hormones. Steroids 120-127 estrogen receptor 1 Rattus norvegicus 23-40 23180186-0 2013 Steroid-responsive hearing impairment in NMO-IgG/aquaporin-4-antibody-positive neuromyelitis optica. Steroids 0-7 aquaporin 4 Homo sapiens 49-60 9296373-1 1997 We have identified several estrogen receptor (ER) mRNA isoforms in rat pituitary and characterized their regulation by gonadal steroids. Steroids 127-135 estrogen receptor 1 Rattus norvegicus 27-44 9296373-1 1997 We have identified several estrogen receptor (ER) mRNA isoforms in rat pituitary and characterized their regulation by gonadal steroids. Steroids 127-135 estrogen receptor 1 Rattus norvegicus 46-48 9296373-9 1997 Thus, ER mRNA variants exist in estrogen-responsive tissues; the pituitary contains at least one tissue-specific ER which is regulated by steroids and which may contribute to changes in regulated biological activity. Steroids 138-146 estrogen receptor 1 Rattus norvegicus 6-8 23200733-4 2013 Carbon atoms C3 (which always carries a alpha-hydroxy group in natural bile acids), and C10 and C13 (which always carry beta-methyl groups) of each steroid residue are suitable for this purpose. Steroids 148-155 homeobox C13 Homo sapiens 96-99 9296373-9 1997 Thus, ER mRNA variants exist in estrogen-responsive tissues; the pituitary contains at least one tissue-specific ER which is regulated by steroids and which may contribute to changes in regulated biological activity. Steroids 138-146 estrogen receptor 1 Rattus norvegicus 113-115 9231785-9 1997 Mitogen-stimulated MAP-kinase kinase and MAP-K activities were significantly inhibited by either E or P. The steroids also inhibited mitogen-stimulated c-fos and c-myc, downstream targets for MAP-K action. Steroids 109-117 MYC proto-oncogene, bHLH transcription factor Homo sapiens 162-167 23995665-4 2013 In addition to the progesterone inactivation, the formation of estrogens and metabolism of the tocolytic steroid by AKR1C5 may be related to its role in rabbit parturition. Steroids 105-112 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 116-122 9228040-8 1997 These data support the view that hsp90 actively participates in steroid-induced signal transduction, and they suggest that geldanamycin affects receptor action without disrupting hsp90-containing heterocomplexes per se. Steroids 64-71 heat shock protein 90 alpha family class A member 1 Homo sapiens 33-38 24171158-8 2013 Isolated inhibitors, such as steroids, terpenoids, and phenolic compounds, are able to inhibit PLA2s from different snake venoms. Steroids 29-37 phospholipase A2 group IIA Homo sapiens 95-100 24235972-9 2013 Nevertheless, T-bet/GATA3>1 is also correlated with C4d-negative ABMR and resistance to steroid treatment. Steroids 91-98 GATA binding protein 3 Homo sapiens 20-25 9221909-0 1997 Regulation of preoptic area gonadotrophin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat. Steroids 94-102 gonadotropin releasing hormone 1 Rattus norvegicus 28-59 23879537-5 2013 The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) functions as a steroid hormone that, when bound to its nuclear vitamin D receptor, is able to regulate target gene expression. Steroids 82-97 vitamin D receptor Homo sapiens 130-148 9221909-0 1997 Regulation of preoptic area gonadotrophin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat. Steroids 94-102 gonadotropin releasing hormone 1 Rattus norvegicus 61-65 23956775-6 2013 The gender- and ovarian steroid-dependent recruitment of spinal cord MOR/kappa opioid receptor (KOR) heterodimers enhances antinociceptive functions and if impaired could contribute to chronic pain states in women. Steroids 24-31 opioid receptor kappa 1 Homo sapiens 69-94 23956775-6 2013 The gender- and ovarian steroid-dependent recruitment of spinal cord MOR/kappa opioid receptor (KOR) heterodimers enhances antinociceptive functions and if impaired could contribute to chronic pain states in women. Steroids 24-31 opioid receptor kappa 1 Homo sapiens 96-99 9221909-9 1997 Frequency analysis of relative GnRH mRNA expression/cell showed that the rostral preoptic GnRH population responded to the steroid treatment in an homogeneous manner. Steroids 123-130 gonadotropin releasing hormone 1 Rattus norvegicus 31-35 9221909-9 1997 Frequency analysis of relative GnRH mRNA expression/cell showed that the rostral preoptic GnRH population responded to the steroid treatment in an homogeneous manner. Steroids 123-130 gonadotropin releasing hormone 1 Rattus norvegicus 90-94 23291669-1 2013 OBJECTIVE: The calcineurin inhibitor tacrolimus has been shown to be safe and effective as salvage therapy for steroid-refractory ulcerative colitis (UC). Steroids 111-118 calcineurin binding protein 1 Homo sapiens 15-36 9221909-11 1997 Further, we show that the gonadal steroid regulation of cellular GnRH mRNA content at such time occurs only through an estrogen receptor-mediated pathway. Steroids 34-41 gonadotropin releasing hormone 1 Rattus norvegicus 65-69 9815800-8 1997 We speculate that PSA expression was mediated by the exogenously administered steroid beclomethasone. Steroids 78-85 kallikrein related peptidase 3 Homo sapiens 18-21 23076525-1 2013 Progesterone receptor (PGR) and estrogen receptor alpha (ESRalpha), which mediate the biological effects of the steroid hormones progesterone and estrogen, play a central role in the establishment and maintenance of pregnancy. Steroids 112-128 progesterone receptor Bos taurus 0-21 23076525-1 2013 Progesterone receptor (PGR) and estrogen receptor alpha (ESRalpha), which mediate the biological effects of the steroid hormones progesterone and estrogen, play a central role in the establishment and maintenance of pregnancy. Steroids 112-128 progesterone receptor Bos taurus 23-26 9202245-10 1997 UGT2B17 was shown to be more labile than UGT2B15, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 164-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 0-7 9202245-10 1997 UGT2B17 was shown to be more labile than UGT2B15, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 164-172 UDP glucuronosyltransferase family 2 member B15 Homo sapiens 41-48 9202245-10 1997 UGT2B17 was shown to be more labile than UGT2B15, indicating that regulation of UGT2B17 expression would lead to a more rapid change in the level of glucuronidated steroids. Steroids 164-172 UDP glucuronosyltransferase family 2 member B17 Homo sapiens 80-87 24171337-3 2013 Serum calcium, FGF23 and iPTH levels responded to steroids, which occurred simultaneously with disease activity. Steroids 50-58 fibroblast growth factor 23 Homo sapiens 15-20 9234254-7 1997 Treatment with steroid (two series of 3 days of 1,000mg methylprednisolone DIV, followed by 60mg oral prednisolone) brought about a dramatic improvement in mental and ocular symptoms corresponding with the CSF findings. Steroids 15-22 colony stimulating factor 2 Homo sapiens 206-209 9238254-2 1997 Thus, the HPA axis exerts profound, mostly inhibitory effects, on the reproductive axis, with corticotropin-releasing hormone (CRH) and CRH-induced propiomelanocortin peptides inhibiting hypothalamic GnRH secretion, and with glucocorticoids inhibiting pituitary LH and ovarian estrogen and progesterone secretion and rendering estrogen-target tissues, such as the endometrium, resistant to the gonadal steroid. Steroids 402-409 corticotropin releasing hormone Homo sapiens 136-139 22562579-2 2012 Subsequent studies have established NcoA4 as a coactivator for a variety of nuclear receptors, including peroxisome proliferator activated receptors alpha and gamma, and receptors for steroid hormones, vitamins D and A, thyroid hormone, and aryl hydrocarbons. Steroids 184-200 nuclear receptor coactivator 4 Homo sapiens 36-41 23012064-6 2012 With a Delta(5)-3-ketosteroid isomerase adsorbed PDDA-QD complex, the biorecognition of steroids was demonstrated through the application of fluorescent resonance energy transfer. Steroids 88-96 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 7-39 9220147-2 1997 In the present paper we report that a fraction of 1.25-dihydroxyvitamin D3 receptor (VDR) immunoreactive neurons in the hypothalamus of male rats are immunoreactive for oxytocin (OT), suggesting a direct genomic action of this steroid on OT expression. Steroids 227-234 vitamin D receptor Rattus norvegicus 50-83 23388484-13 2012 RANKL levels remain within normal range on standard steroid replacement. Steroids 52-59 TNF superfamily member 11 Homo sapiens 0-5 9220147-2 1997 In the present paper we report that a fraction of 1.25-dihydroxyvitamin D3 receptor (VDR) immunoreactive neurons in the hypothalamus of male rats are immunoreactive for oxytocin (OT), suggesting a direct genomic action of this steroid on OT expression. Steroids 227-234 vitamin D receptor Rattus norvegicus 85-88 9183567-7 1997 The observations that hsp90 binds to the receptors through their HBDs and that these domains can be fused to structurally different proteins bringing their function under hormonal control provided a powerful linkage between the hormonal regulation of receptor binding to hsp90 and the initial step in steroid hormone action. Steroids 301-316 heat shock protein 90 alpha family class A member 1 Homo sapiens 22-27 22959515-7 2012 The expression of StAR, P450scc and HSD factors maintained low in early luteal phase, after that level of expression increased steadily to show a significant rise (P<0.05) in mid luteal phase followed by gradual decline in late luteal phase and regressed CL and this correlates well with the Ob and ObR receptor activity, verifying their key role in progesterone and other steroids production in functional CL. Steroids 376-384 steroidogenic acute regulatory protein, mitochondrial Bubalus bubalis 18-22 9183567-7 1997 The observations that hsp90 binds to the receptors through their HBDs and that these domains can be fused to structurally different proteins bringing their function under hormonal control provided a powerful linkage between the hormonal regulation of receptor binding to hsp90 and the initial step in steroid hormone action. Steroids 301-316 heat shock protein 90 alpha family class A member 1 Homo sapiens 271-276 9165036-3 1997 To investigate further this latter observation, we have determined the effects of this steroid on expression of the GHRH receptor (GHRH-R) gene in the rat pituitary in vivo and in pituitary cells in vitro. Steroids 87-94 growth hormone releasing hormone receptor Rattus norvegicus 116-129 22771765-2 2012 TSPO is involved in physiological functions among which transport of molecules such as cholesterol to form steroids and bile salts in mammalian cells. Steroids 107-115 translocator protein Homo sapiens 0-4 23153702-7 2012 However, the treatment with both steroids decreased the secretion of TNF-alpha, IL-18 and TGF-beta1 by EEC in the presence of ESC. Steroids 33-41 interleukin 18 Homo sapiens 80-85 9165036-3 1997 To investigate further this latter observation, we have determined the effects of this steroid on expression of the GHRH receptor (GHRH-R) gene in the rat pituitary in vivo and in pituitary cells in vitro. Steroids 87-94 growth hormone releasing hormone receptor Rattus norvegicus 131-137 9165036-11 1997 These data demonstrate that GHRH-R mRNA levels are directly stimulated by glucocorticoids, both in the presence and absence of hypothalamic influences, providing a probable explanation for the ability of this steroid to alter pituitary responsiveness to GHRH. Steroids 209-216 growth hormone releasing hormone receptor Rattus norvegicus 28-34 22986075-9 2012 However, only substituted steroids with C19 hydroxylations exhibited specificity to TSPO, its CRAC motif, and mitochondrial cholesterol transport, as the C4, C7, and C11 hydroxylated steroids inhibited the metabolic transformation of cholesterol by CYP11A1. Steroids 26-34 translocator protein Homo sapiens 84-88 22986075-9 2012 However, only substituted steroids with C19 hydroxylations exhibited specificity to TSPO, its CRAC motif, and mitochondrial cholesterol transport, as the C4, C7, and C11 hydroxylated steroids inhibited the metabolic transformation of cholesterol by CYP11A1. Steroids 26-34 aldo-keto reductase family 1 member C4 Homo sapiens 166-169 22986075-9 2012 However, only substituted steroids with C19 hydroxylations exhibited specificity to TSPO, its CRAC motif, and mitochondrial cholesterol transport, as the C4, C7, and C11 hydroxylated steroids inhibited the metabolic transformation of cholesterol by CYP11A1. Steroids 183-191 translocator protein Homo sapiens 84-88 22986075-9 2012 However, only substituted steroids with C19 hydroxylations exhibited specificity to TSPO, its CRAC motif, and mitochondrial cholesterol transport, as the C4, C7, and C11 hydroxylated steroids inhibited the metabolic transformation of cholesterol by CYP11A1. Steroids 183-191 aldo-keto reductase family 1 member C4 Homo sapiens 166-169 23035244-9 2012 Binding was weakened by structural changes in LCA, and so it may be a natural ligand of MDM2 and MDM4, raising the possibility that MDM proteins may be sensors for specific steroids. Steroids 173-181 MDM2 proto-oncogene Homo sapiens 88-92 22885098-7 2012 The human mitochondrial steroid hydroxylating enzymes CYP11B1 and CYP11B2 were capable to metabolize metandienone leading to the formation of 11beta-hydroxymetandienone and 18-hydroxymetandienone. Steroids 24-31 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 54-61 9176799-7 1997 IL-4 and IL-13 mRNA expression was suppressed in ACS subjects on topical steroid therapy compared to untreated patients. Steroids 73-80 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 49-52 9148915-1 1997 The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. Steroids 74-81 heat shock protein 90 alpha family class A member 1 Homo sapiens 12-17 9148915-1 1997 The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. Steroids 74-81 stress induced phosphoprotein 1 Homo sapiens 18-21 22910411-1 2012 The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. Steroids 92-99 nuclear receptor subfamily 1 group I member 3 Homo sapiens 4-36 22910411-1 2012 The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. Steroids 92-99 nuclear receptor subfamily 1 group I member 3 Homo sapiens 38-41 9148915-3 1997 The glucocorticoid receptor (GR) is bound to hsp90 via its hormone binding domain (HBD), which must be associated with hsp90 to have a steroid binding conformation. Steroids 135-142 heat shock protein 90 alpha family class A member 1 Homo sapiens 45-50 22958837-0 2012 Endometrial stromal beta-catenin is required for steroid-dependent mesenchymal-epithelial cross talk and decidualization. Steroids 49-56 catenin (cadherin associated protein), beta 1 Mus musculus 20-32 9148915-3 1997 The glucocorticoid receptor (GR) is bound to hsp90 via its hormone binding domain (HBD), which must be associated with hsp90 to have a steroid binding conformation. Steroids 135-142 heat shock protein 90 alpha family class A member 1 Homo sapiens 119-124 22958837-2 2012 When allowed to accumulate to sufficient levels in its dephosphorylated form, beta-catenin serves as a transcriptional co-activator associated with a number of signaling pathways, including steroid hormone signaling pathways. Steroids 190-205 catenin (cadherin associated protein), beta 1 Mus musculus 78-90 9148915-8 1997 In this work we show that when the GR is incubated with hsp90, hsp70, and p60, steroid binding sites are generated despite the absence of p23. Steroids 79-86 heat shock protein 90 alpha family class A member 1 Homo sapiens 56-61 22579571-3 2012 A major and unexpected finding was the down-regulation of genes involved in the biosynthesis of cholesterol and other steroids and lipids (such as Fdft1, Fdps, Idi1, Ldr, Mvd, Mvk, Nsdhl, Sc4mol), the expression of which was verified by quantitative real-time RT-PCR (qPCR). Steroids 118-126 farnesyl diphosphate synthase Homo sapiens 154-158 9148915-8 1997 In this work we show that when the GR is incubated with hsp90, hsp70, and p60, steroid binding sites are generated despite the absence of p23. Steroids 79-86 stress induced phosphoprotein 1 Homo sapiens 74-77 22579571-3 2012 A major and unexpected finding was the down-regulation of genes involved in the biosynthesis of cholesterol and other steroids and lipids (such as Fdft1, Fdps, Idi1, Ldr, Mvd, Mvk, Nsdhl, Sc4mol), the expression of which was verified by quantitative real-time RT-PCR (qPCR). Steroids 118-126 NAD(P) dependent steroid dehydrogenase-like Homo sapiens 181-186 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 heat shock protein 90 alpha family class A member 1 Homo sapiens 27-32 22579571-3 2012 A major and unexpected finding was the down-regulation of genes involved in the biosynthesis of cholesterol and other steroids and lipids (such as Fdft1, Fdps, Idi1, Ldr, Mvd, Mvk, Nsdhl, Sc4mol), the expression of which was verified by quantitative real-time RT-PCR (qPCR). Steroids 118-126 methylsterol monooxygenase 1 Homo sapiens 188-194 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 stress induced phosphoprotein 1 Homo sapiens 82-85 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 heat shock protein 90 alpha family class A member 1 Homo sapiens 125-130 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 stress induced phosphoprotein 1 Homo sapiens 131-134 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 stress induced phosphoprotein 1 Homo sapiens 131-134 9160728-0 1997 Human decidual cell biosynthesis of leukemia inhibitory factor: regulation by decidual cytokines and steroid hormones. Steroids 101-117 LIF interleukin 6 family cytokine Homo sapiens 36-62 9160728-2 1997 We investigated the regulation of LIF production by decidual cytokines and steroid hormones. Steroids 75-91 LIF interleukin 6 family cytokine Homo sapiens 34-37 9143029-5 1997 However, that of adrenal 4 binding protein, a transcription factor of steroidogenesis, was present in almost all the tumor cells as well as luteinized stromal cells, suggesting that tumor cells acquired the potential of metabolizing and synthesizing steroid hormones. Steroids 250-266 nuclear receptor subfamily 5 group A member 1 Homo sapiens 17-42 9143323-7 1997 Kinetic analysis indicated that mouse CYP2G1 has relatively high affinities toward the steroid substrates, with K(m) values in the micromolar range for both testosterone and progesterone. Steroids 87-94 cytochrome P450, family 2, subfamily g, polypeptide 1 Mus musculus 38-44 9180390-2 1997 The inhibition of growth and proliferation of tumor cells in vitro by GnRH and its analogs indicates that the tumor suppressing effect of the hormone is only partially due to suppression of pituitary gonadotropin release which reduces circulating steroid levels that are required for proliferation. Steroids 247-254 gonadotropin releasing hormone 1 Mus musculus 70-74 9075729-1 1997 Abundant evidence suggests that opiatergic neurons play an important intermediary role in the regulation of LHRH release by ovarian steroids; however, it is unclear whether opiates communicate directly or indirectly with LHRH neurons. Steroids 132-140 gonadotropin releasing hormone 1 Rattus norvegicus 108-112 9812858-7 1997 The above data indicated that the proliferative effect of IL-2 on AP is a joint action of sex steroids hormones. Steroids 94-102 interleukin 2 Rattus norvegicus 58-62 9142695-5 1997 Besides this, the presence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the key enzyme in the de novo cholesterol synthesis from acetate) and of sterol carrier protein-2 (SCP2), which is involved in the cholesterol metabolism and steroid metabolic pathways, are located in peroxisomes of steroid-secreting cells. Steroids 237-244 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 30-77 9142695-5 1997 Besides this, the presence of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the key enzyme in the de novo cholesterol synthesis from acetate) and of sterol carrier protein-2 (SCP2), which is involved in the cholesterol metabolism and steroid metabolic pathways, are located in peroxisomes of steroid-secreting cells. Steroids 295-302 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 30-77 9062481-2 1997 We have found that in female tissues the PSA gene is regulated by steroid hormones through the action of steroid hormone receptors. Steroids 66-82 kallikrein related peptidase 3 Homo sapiens 41-44 9155738-0 1997 Leukaemia inhibitory factor in endometrium during the oestrous cycle, early pregnancy and in ovariectomized steroid-treated ewes. Steroids 108-115 leukemia inhibitory factor Mus musculus 0-27 9155738-8 1997 Ovariectomized steroid-treated ewes were studied to establish whether steroid hormones had a role in regulating endometrial LIF. Steroids 15-22 leukemia inhibitory factor Mus musculus 124-127 25285401-3 2015 Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes of plasticity in nucleus HVC of adult birds, including the addition of newborn neurons. Steroids 0-8 brain derived neurotrophic factor Homo sapiens 27-39 9155738-8 1997 Ovariectomized steroid-treated ewes were studied to establish whether steroid hormones had a role in regulating endometrial LIF. Steroids 70-86 leukemia inhibitory factor Mus musculus 124-127 25285401-3 2015 Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes of plasticity in nucleus HVC of adult birds, including the addition of newborn neurons. Steroids 0-8 brain derived neurotrophic factor Homo sapiens 75-79 9155738-10 1997 These studies demonstrate the presence of mRNA encoding LIF and protein throughout the oestrous cycle and early pregnancy and suggest that steroid hormones may be involved in their regulation. Steroids 139-155 leukemia inhibitory factor Mus musculus 56-59 25285401-6 2015 The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin and coordinating circuit function in reproductively relevant contexts. Steroids 30-38 brain derived neurotrophic factor Homo sapiens 42-46 25285401-6 2015 The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin and coordinating circuit function in reproductively relevant contexts. Steroids 30-38 brain derived neurotrophic factor Homo sapiens 113-125 15739391-5 1997 The response of the ELSD was non-linear as a result of basic light-scattering principles, the calibration curve by plotting lnY vs lnX (Y, X stand for peak area and concentration, respectively) shows a good linearity in the range of 5-50mg/L with a correlation coefficient higher than 0.99 for individual steroid and with relative standard deviation less than 6.92%. Steroids 305-312 ligand of numb-protein X 1 Homo sapiens 131-134 9052741-1 1997 The rat UDP glucuronosyltransferase UGT2B1 is expressed mainly in the liver where it glucuronidates steroids and environmental toxins and carcinogens. Steroids 100-108 UDP glucuronosyltransferase family 2 member B17 Rattus norvegicus 36-42 25747464-10 2015 Such an effect might be caused by the influence of DHEAS on serotonin neurotransmission, as this steroid decreased serotonin concentration and turnover in the striatum. Steroids 97-104 sulfotransferase family 2A member 1 Homo sapiens 51-56 25662808-1 2015 STUDY QUESTION: Are brain-derived neurotrophic factor (BDNF) and its receptors, NTRK2, NGFR and SORT1, regulated by ovarian steroids in the uterus? Steroids 124-132 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 80-85 25662808-1 2015 STUDY QUESTION: Are brain-derived neurotrophic factor (BDNF) and its receptors, NTRK2, NGFR and SORT1, regulated by ovarian steroids in the uterus? Steroids 124-132 sortilin 1 Mus musculus 96-101 9013761-1 1997 Steroidogenic acute regulatory protein (StAR) delivers cholesterol to the inner mitochondrial membrane, where the cholesterol side-chain cleavage enzyme carries out the first committed step in steroid hormone biosynthesis. Steroids 193-208 steroidogenic acute regulatory protein Mus musculus 40-44 25730708-2 2015 TSPO has long been described as being indispensable for mitochondrial cholesterol import that is essential for steroid hormone production. Steroids 111-126 translocator protein Homo sapiens 0-4 9052414-0 1997 Steroid hormone regulation of prostate-specific antigen gene expression in breast cancer. Steroids 0-15 kallikrein related peptidase 3 Homo sapiens 30-55 25730708-5 2015 In this minireview, we recapitulate the key studies from 25 years of TSPO research and concurrently examine their limitations that perhaps led towards the incorrect association of TSPO and steroid hormone production. Steroids 189-204 translocator protein Homo sapiens 180-184 25748225-1 2015 To examine the therapeutic effect of Src inhibitor on the VEGF mediating vascular hyperpermeability and bone destruction within steroid-associated osteonecrotic lesions in rabbits. Steroids 128-135 vascular endothelial growth factor A Oryctolagus cuniculus 58-62 9081543-1 1997 Human uteroglobin (h-UG) or Clara cell 10kDa (cc10kDa) is a steroid-dependent, 17 kDa homodimeric, secretory protein with potent anti-inflammatory/immunomodulatory properties. Steroids 60-67 secretoglobin family 1A member 1 Homo sapiens 6-17 24777823-2 2015 This makes it likely that the AHR and additional components of the AHR signalling pathway are under the control of female sex steroids. Steroids 126-134 aryl hydrocarbon receptor Rattus norvegicus 30-33 24777823-2 2015 This makes it likely that the AHR and additional components of the AHR signalling pathway are under the control of female sex steroids. Steroids 126-134 aryl hydrocarbon receptor Rattus norvegicus 67-70 9441539-5 1997 Molecular research during the last ten years has found that sexual steroids may interact with the central nervous system via the GABA-receptor. Steroids 67-75 GABA type A receptor-associated protein Homo sapiens 129-142 25767421-2 2015 Our pilot study was the first to assess the utility of the six-item CTS symptom scale (CTS-6) with steroid injections as a patient-directed outcome measure for the treatment of CTS. Steroids 99-106 transthyretin Homo sapiens 68-71 25767421-15 2015 CONCLUSIONS: The six-item CTS symptoms scale and portable NCS are both useful measures for evaluating the results of steroid injections. Steroids 117-124 transthyretin Homo sapiens 26-29 25767421-16 2015 The CTS-6 is an effective tool because of its ease of use, low cost, correspondence with changes in NCS, and ability to monitor the outcome of steroid treatment for carpal tunnel syndrome. Steroids 143-150 transthyretin Homo sapiens 4-7 8988026-2 1996 Its striking homology with the so-called sigma1 receptor of guinea pig brain, a polyvalent steroid and drug binding protein, suggested that the yeast sterol C8-C7 isomerase (ERG2) carries a similar high affinity drug binding domain. Steroids 91-98 C-8 sterol isomerase ERG2 Saccharomyces cerevisiae S288C 174-178 8940170-0 1996 Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. Steroids 43-51 multidrug transporter Saccharomyces cerevisiae S288C 79-100 22521564-7 2012 This article represents a summary of a lecture given at the 7(th) International Meeting on Rapid Responses to Steroid Hormones in September 2011 in Axos, Crete, and reviews the current knowledge and questions about GPER-dependent signaling and function. Steroids 110-126 G protein-coupled estrogen receptor 1 Homo sapiens 215-219 8939864-2 1996 The steroid aporeceptor complex contains the molecular chaperones Hsp90 and Hsp70, p48, the cyclophilin Cyp-40, and the associated proteins p23 and p60. Steroids 4-11 heat shock protein 90 alpha family class A member 1 Homo sapiens 66-71 22444300-7 2012 The proportions of steroid-resistant rejection, incomplete recovery and recurrent ATCMR were higher in the IL-17 high group than in the FOXP3 high group (all indicators, P < 0 05). Steroids 19-26 interleukin 17A Homo sapiens 107-112 26027352-5 2015 The proposed microbiological method for producing steroid lactones opens prospects for the syn- thesis of novel steroid compounds. Steroids 50-57 synemin Homo sapiens 91-94 8939864-2 1996 The steroid aporeceptor complex contains the molecular chaperones Hsp90 and Hsp70, p48, the cyclophilin Cyp-40, and the associated proteins p23 and p60. Steroids 4-11 prostaglandin E synthase 3 Homo sapiens 140-143 8939864-2 1996 The steroid aporeceptor complex contains the molecular chaperones Hsp90 and Hsp70, p48, the cyclophilin Cyp-40, and the associated proteins p23 and p60. Steroids 4-11 stress induced phosphoprotein 1 Homo sapiens 148-151 8968370-5 1996 This P450 appeared to be the preferred target for inhibition, because the observed K/K(m) ratio for inhibition of CYP3A2-dependent steroid hydroxylation was approximately 4- and 100-fold lower than those for CYP2C11 and CYP2A1-dependent pathways, respectively. Steroids 131-138 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 208-215 25583050-11 2015 Compared to the healthy population, a significant higher IRR is observed in JIA patients who received a monotherapy with etanercept or in combination with steroids and methotrexate, but not in JIA patients exposed to methotrexate without biologics. Steroids 155-163 insulin receptor related receptor Homo sapiens 57-60 9042323-7 1996 Using this system, we showed that PSA regulation is under the control of steroid hormones and their receptors. Steroids 73-89 kallikrein related peptidase 3 Homo sapiens 34-37 25880059-4 2015 Because of its nature as external monooxygenase, CYP11B1-dependent steroid hydroxylation requires reducing equivalents which are provided from NADPH via a redox chain, consisting of adrenodoxin reductase (AdR) and adrenodoxin (Adx). Steroids 67-74 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 49-56 25496429-2 2015 In the ewe, neurones of the arcuate nucleus (ARC), which co-expresses kisspeptin, neurokinin B (NKB) and dynorphin (termed KNDy cells), play a key role in steroid feedback control of GnRH and show altered peptide expression after prenatal testosterone treatment. Steroids 155-162 tachykinin-3 Ovis aries 82-94 22336701-3 2012 Therefore, the aim of our study was to explore in-vivo the effects of steroid with repetitive procaine HCl injection on the median nerve of patients with CTS. Steroids 70-77 transthyretin Homo sapiens 154-157 22336701-9 2012 CONCLUSION: Steroid injection with repetitive procaine HCl injection effectively reduced the symptoms of CTS, improved the Boston carpal tunnel symptom and function assessment scale and also electrophysiological and ultrasonographic findings. Steroids 12-19 transthyretin Homo sapiens 105-108 25496429-3 2015 KNDy cells also co-localise NKB receptors (NK3R), and it has been proposed that NKB may act as an autoregulatory transmitter in KNDy cells where it participates in the mechanisms underlying steroid negative-feedback. Steroids 190-197 tachykinin-3 Ovis aries 80-83 8969896-1 1996 Computer modelling and site-directed mutagenesis were employed to investigate the structural basis for the regioselectivity of steroid hydroxylation and to determine whether point mutations of CYP11B1 and CYP11B2 can result in changes in the ratio of glucocorticoids/mineralocorticoids. Steroids 127-134 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 205-212 25617625-1 2015 UNLABELLED: The purpose of the study was to determine the effect of ginseng-based steroid Rg1 on TNF-alpha and IL-10 gene expression in human skeletal muscle against exercise challenge, as well as on its ergogenic outcomes. Steroids 82-89 interleukin 10 Homo sapiens 111-116 22510985-2 2012 In this study, we show that the Drosophila steroid hormone 20-hydroxyecdysone (20E) and its nuclear receptor directly activate transcription of the evolutionarily conserved let-7-complex (let-7-C) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125. Steroids 43-58 mir-125 stem loop Drosophila melanogaster 266-273 8980167-2 1996 Recent studies provided evidence that both steroids exert effects on different pathways of GnRH signal transduction, which might be responsible for their actions on luteinizing hormone (LH) release. Steroids 43-51 gonadotropin releasing hormone 1 Rattus norvegicus 91-95 25590624-3 2015 The role of 3beta-hydroxysteroid dehydrogenase (3betaHSD) in regulation of steroid metabolism was also validated using trilostane, a specific 3betaHSD inhibitor. Steroids 25-32 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 48-56 8980167-3 1996 Here we investigated whether the steroids are able to modulate GnRH-induced liberation of arachidonic acid, which is thought to be involved in GnRH signal transduction. Steroids 33-41 gonadotropin releasing hormone 1 Rattus norvegicus 63-67 21631238-1 2012 OBJECTIVE: HSD3B1 gene encodes the 3beta-hydroxysteroid deydrogenases/isomerase (3beta-HSD) enzyme, which plays a crucial role in the biosynthesis of all hormonal steroids. Steroids 163-171 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-17 8980167-3 1996 Here we investigated whether the steroids are able to modulate GnRH-induced liberation of arachidonic acid, which is thought to be involved in GnRH signal transduction. Steroids 33-41 gonadotropin releasing hormone 1 Rattus norvegicus 143-147 25583233-1 2015 BACKGROUND: Pig aldo-keto reductase family 1 member C1 (AKR1C1) belongs to AKR superfamily which catalyzes the NAD(P)H-dependent reduction of various substrates including steroid hormones. Steroids 171-187 aldo-keto reductase family 1 member C1 Sus scrofa 16-54 11667606-2 1996 Steroids have been prepared that bear a dimethylphenylsiloxy (DPSO) group and additional C3 and/or C17 ketone functionalities. Steroids 0-8 cytokine like 1 Homo sapiens 99-102 25583233-1 2015 BACKGROUND: Pig aldo-keto reductase family 1 member C1 (AKR1C1) belongs to AKR superfamily which catalyzes the NAD(P)H-dependent reduction of various substrates including steroid hormones. Steroids 171-187 aldo-keto reductase family 1 member C1 Sus scrofa 56-62 25986567-2 2015 Aberrant expression of these TPR immunophilins has the potential to cause steroid-based diseases, including breast and prostate cancer, diabetes and metabolic disorders, male and female infertility and major depressive and neurodegenerative disorders. Steroids 74-81 translocated promoter region, nuclear basket protein Homo sapiens 29-32 24832628-1 2015 Androstenedione is a common precursor of sex steroids produced and secreted in the human adrenal gland and produced by 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17beta-hydroxylase/17,20-lyase (CYP17) and cytochrome b5 (CYB5A). Steroids 45-53 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 119-153 24832628-1 2015 Androstenedione is a common precursor of sex steroids produced and secreted in the human adrenal gland and produced by 3beta-hydroxysteroid dehydrogenase (3betaHSD), 17beta-hydroxylase/17,20-lyase (CYP17) and cytochrome b5 (CYB5A). Steroids 45-53 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 155-163 25304940-4 2015 Plasma concentrations of steroid metabolites associated with reactions catalyzed by CYP11B2 and CYP11B1 were measured concurrently by a UPLC/MS method. Steroids 25-32 cytochrome P450 family 11 subfamily B member 2 Macaca mulatta 84-91 8816441-8 1996 Taken together, these results demonstrate that the steroid-induced expression of C/EBP alpha is necessary to mediate the glucocorticoid G1 cell cycle arrest of rat hepatoma cells and implicates a role for this transcription factor in the growth control of liver-derived epithelial tumor cells. Steroids 51-58 CCAAT/enhancer binding protein alpha Rattus norvegicus 81-92 9120437-0 1996 FOS expression in grafted gonadotropin-releasing hormone neurons in hypogonadal mouse: mating and steroid induction. Steroids 98-105 FBJ osteosarcoma oncogene Mus musculus 0-3 25121488-3 2015 OUTCOMES: Therapy in patients with steroid dependence and CNI-dependent steroid resistance led to significantly reduced relapse rates (respective mean difference 2.7 relapses/year and 2.2 relapses/year, corresponding to a decrease in relapses by 81.8 and 71.0%; both P < 0.0001). Steroids 72-79 calcineurin binding protein 1 Homo sapiens 58-61 9120437-0 1996 FOS expression in grafted gonadotropin-releasing hormone neurons in hypogonadal mouse: mating and steroid induction. Steroids 98-105 gonadotropin releasing hormone 1 Mus musculus 26-56 25121488-5 2015 Remission was longer in patients with steroid dependence compared with CNI-dependent steroid resistance (median 16 versus 10 months; P < 0.0001). Steroids 85-92 calcineurin binding protein 1 Homo sapiens 71-74 25121488-6 2015 Prior response to cyclophosphamide predicted a lower risk of relapse in the former (hazard ratio, HR 0.56; P = 0.045); patients with initial resistance and CNI-dependent steroid resistance had increased risk of relapse (HR 2.66; P = 0.042). Steroids 170-177 calcineurin binding protein 1 Homo sapiens 156-159 9120437-8 1996 The present results support the hypothesis that host-derived activation of grafted GnRH neurons underlies aspects of reproductive responses seen in hpg mice with grafts, and further, that at least a portion of the host-graft connectivity is steroid sensitive. Steroids 241-248 gonadotropin releasing hormone 1 Mus musculus 83-87 25121488-11 2015 CONCLUSIONS: Therapy with rituximab is effective and safe in reducing relapse rates and need for immunosuppressive medications in patients with steroid-dependent and CNI-dependent steroid-resistant nephrotic syndrome. Steroids 180-187 calcineurin binding protein 1 Homo sapiens 166-169 8828857-7 1996 The steroid hormone responsiveness of GE cells was monitored by changes in steady-state levels of ALP mRNA after 24-h exposure to estradiol 17 beta (E2; 10 nM) and/or progesterone (P; 10 nM). Steroids 4-11 antileukoproteinase Sus scrofa 98-101 26044829-0 2015 Effects of intranasal oxytocin on steroid hormones in men and women. Steroids 34-50 oxytocin/neurophysin I prepropeptide Homo sapiens 22-30 8754747-14 1996 We conclude that 1) gonadal steroids have disparate effects on somatic growth in female rats, with E2 suppressing and DHT stimulating body weight gain; 2) these effects are likely to be primarily mediated at the level of IGF-I synthesis and secretion; and 3) changes in pituitary GH content and secretion probably reflect normal adjustment to changes in the intensity of IGF-I negative feedback. Steroids 28-36 insulin-like growth factor 1 Rattus norvegicus 221-226 26044829-2 2015 Few studies have examined the effects of intranasal oxytocin on steroid hormones. Steroids 64-80 oxytocin/neurophysin I prepropeptide Homo sapiens 52-60 8866247-3 1996 These observations which were made in the rat suggest that GnRH neurons are directly affected by the gonadal steroid milieu, though they do not themselves contain receptors for these steroidal hormones. Steroids 109-116 gonadotropin releasing hormone 1 Rattus norvegicus 59-63 25475875-7 2014 We show that this framework has broad scope by providing new insights into three very different ad hoc models, of steroid-hormone responsive genes, of inherently bounded chromatin domains and of the yeast PHO5 gene. Steroids 114-121 acid phosphatase PHO5 Saccharomyces cerevisiae S288C 205-209 8918985-2 1996 The transition from C21 to C19 steroids is apparently controlled by the same cytochrome P450c17 expressed in the testis, which catalyzes both 17alpha-hydroxylation and C-17,20 bond scission at a single bifunctional active site. Steroids 31-39 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 88-95 25416481-7 2014 The regulated proteins are those involved in early stages of steroid biosynthesis (SOAT1, NPC1, and ACBD5) and C21-steroid hormone metabolism (CYP21A2 and HSD3B1). Steroids 61-68 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 155-161 25416481-7 2014 The regulated proteins are those involved in early stages of steroid biosynthesis (SOAT1, NPC1, and ACBD5) and C21-steroid hormone metabolism (CYP21A2 and HSD3B1). Steroids 115-130 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 155-161 8708566-11 1996 In summary, the present study has demonstrated that (1) immature rats treated with an LHRH antagonist can be used to study the effects of gonadotrophins and steroids on follicular function and (2) RU486 has a direct stimulatory effect on follicular atresia. Steroids 157-165 gonadotropin releasing hormone 1 Rattus norvegicus 86-90 25427574-2 2014 The IL-17 superfamily, which mediates cross-talk between the adaptive and innate immune systems, has been associated with diminished responses to steroids. Steroids 146-154 interleukin 17A Homo sapiens 4-9 24681080-12 2014 CONCLUSIONS: Filaggrin, ZO-3, and claudin-1 (but not ZO-1 or ZO-2) are detected in the esophageal mucosa of patients with EoE treated with steroids and individuals without esophageal disease. Steroids 139-147 claudin 1 Homo sapiens 34-43 8640952-7 1996 The amount of IGF-I-induced association of insulin receptor substrate-1 and phosphatidylinositol 3-kinase was increased in steroid treated cells. Steroids 123-130 insulin receptor substrate 1 Homo sapiens 43-71 25484527-14 2014 We conclude that greater ratio of Tregs compared to that Th1 and Th2 favor steroid sensitivity and reverse ratio results in to SRNS. Steroids 75-82 negative elongation factor complex member C/D Homo sapiens 57-60 25173591-0 2014 CYP18A1 regulates tissue-specific steroid hormone inactivation in Bombyx mori. Steroids 34-49 cytochrome P450 18a1 Bombyx mori 0-7 8640952-12 1996 Furthermore, they suggest that dexamethasone-induced reduction of IRS-1 expression may be important for the impaired activation of MAP kinase by insulin-like peptides in steroid-treated cells. Steroids 170-177 insulin receptor substrate 1 Homo sapiens 66-71 25173591-3 2014 A cytochrome P450 enzyme, CYP18A1, has been shown to play key roles in insect steroid hormone inactivation through 26-hydroxylation. Steroids 78-93 cytochrome P450 18a1 Bombyx mori 26-33 25173591-10 2014 Although the biological significance of MSG-specific expression of BmCYP18A1 is unclear, our results provide the first evidence that BmCYP18A1, which is conserved in most arthropods, is involved in a tissue-specific steroid hormone inactivation in B. mori. Steroids 216-231 cytochrome P450 18a1 Bombyx mori 133-142 8766595-8 1996 Anti-HSP60 labeling in male and female sex steroid producing cells and their progenitors seems to be coordinated with the functional differentiation of these endocrine cells of the gonad. Steroids 43-50 heat shock protein family D (Hsp60) member 1 Rattus norvegicus 5-10 8836160-5 1996 Addition of purified animal (mouse) or plant (wheat germ) hsp70 to the hsp70-depleted lysate permits assembly of a GR-hsp90 heterocomplex with a high affinity steroid binding site. Steroids 159-166 heat shock 70 kDa protein 4 Triticum aestivum 58-63 24800957-5 2014 On the other hand, neuroactive 5alpha-reduced steroids promote glial cell differentiation, resulting in enhancement of their ability to produce brain-derived neurotrophic factor (BDNF). Steroids 46-54 brain derived neurotrophic factor Homo sapiens 144-177 24800957-5 2014 On the other hand, neuroactive 5alpha-reduced steroids promote glial cell differentiation, resulting in enhancement of their ability to produce brain-derived neurotrophic factor (BDNF). Steroids 46-54 brain derived neurotrophic factor Homo sapiens 179-183 8836160-5 1996 Addition of purified animal (mouse) or plant (wheat germ) hsp70 to the hsp70-depleted lysate permits assembly of a GR-hsp90 heterocomplex with a high affinity steroid binding site. Steroids 159-166 heat shock 70 kDa protein 4 Triticum aestivum 71-76 8776730-10 1996 Overall, these findings provide direct pharmacological evidence that hsp90 function is required to maintain both the hormone-binding activity and stability of the GR protein in intact cells and suggest that hsp90 function may provide a novel target for the modulation of steroid hormone signaling. Steroids 271-286 heat shock protein 90 alpha family class A member 1 Homo sapiens 69-74 25092869-1 2014 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) is an enzyme crucial for steroid synthesis. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 40-49 8776730-10 1996 Overall, these findings provide direct pharmacological evidence that hsp90 function is required to maintain both the hormone-binding activity and stability of the GR protein in intact cells and suggest that hsp90 function may provide a novel target for the modulation of steroid hormone signaling. Steroids 271-286 heat shock protein 90 alpha family class A member 1 Homo sapiens 207-212 24947306-8 2014 Peptides able to penetrate testes conjugated to 14-3-3e site of interaction with VDAC1 blocked 14-3-3e-VDAC1 interactions while at the same time increased VDAC1-translocator protein (18 kDa) interactions that induced steroid formation in rat testes, leading to increased serum T levels. Steroids 217-224 voltage-dependent anion channel 1 Rattus norvegicus 81-86 24947306-8 2014 Peptides able to penetrate testes conjugated to 14-3-3e site of interaction with VDAC1 blocked 14-3-3e-VDAC1 interactions while at the same time increased VDAC1-translocator protein (18 kDa) interactions that induced steroid formation in rat testes, leading to increased serum T levels. Steroids 217-224 voltage-dependent anion channel 1 Rattus norvegicus 103-108 8625688-5 1996 INTERVENTIONS: Rabbits with endotoxemia were pretreated with steroids sufficient to inhibit the production of tumor necrosis factor (TNF) and to prevent the fall of BP. Steroids 61-69 tumor necrosis factor Oryctolagus cuniculus 110-131 24947306-8 2014 Peptides able to penetrate testes conjugated to 14-3-3e site of interaction with VDAC1 blocked 14-3-3e-VDAC1 interactions while at the same time increased VDAC1-translocator protein (18 kDa) interactions that induced steroid formation in rat testes, leading to increased serum T levels. Steroids 217-224 voltage-dependent anion channel 1 Rattus norvegicus 103-108 8625688-5 1996 INTERVENTIONS: Rabbits with endotoxemia were pretreated with steroids sufficient to inhibit the production of tumor necrosis factor (TNF) and to prevent the fall of BP. Steroids 61-69 tumor necrosis factor Oryctolagus cuniculus 133-136 24810629-4 2014 ORF32, located in one of the two main steroid degradation gene clusters, was shown to be indispensable for the conversion of this compound. Steroids 38-45 Orf32 Comamonas testosteroni 0-5 8625688-10 1996 CONCLUSIONS: These findings suggest that the lung accumulation of PMNs is dependent on TNF or other inflammatory mediators that are inhibited by steroids while the lung accumulation of monocyte is not. Steroids 145-153 tumor necrosis factor Oryctolagus cuniculus 87-90 8612556-3 1996 The presence of estrogen receptor in both osteoblasts and osteoclasts has suggested a direct role of these steroid hormones on bone tissue. Steroids 107-123 estrogen receptor 1 (alpha) Mus musculus 16-33 25318183-1 2014 PURPOSE: We carried out a national clinical investigation of anti-aquaporin-4 seropositive optic neuritis which is resistant to steroid pulse therapy. Steroids 128-135 aquaporin 4 Homo sapiens 66-77 8792280-0 1996 Interaction among bovine somatotropin, insulin, and gonadotropins on steroid production by bovine granulosa and thecal cells. Steroids 69-76 somatotropin Bos taurus 25-37 25123451-14 2014 The possibility for IL-17-gammadelta T cells to reduce AHR and robust eosinophilic inflammation provides evidence that therapeutic approaches focused on stimulating and increasing airway IL-17-gammadelta T cells may be an effective alternative in treating steroid resistant, severe asthma. Steroids 256-263 interleukin 17A Mus musculus 20-25 25123451-14 2014 The possibility for IL-17-gammadelta T cells to reduce AHR and robust eosinophilic inflammation provides evidence that therapeutic approaches focused on stimulating and increasing airway IL-17-gammadelta T cells may be an effective alternative in treating steroid resistant, severe asthma. Steroids 256-263 interleukin 17A Mus musculus 187-192 24943040-5 2014 We also studied the effects of human recombinant ITLN1 (hRom1) on steroid production and on the activation of various signaling pathways. Steroids 66-73 retinal outer segment membrane protein 1 Homo sapiens 56-61 8622133-3 1996 Because the ability of CREB to activate transcription depends on phosphorylation at Ser133, we also evaluated the effects of acute steroid treatment on levels of phosphorylated CREB (pCREB) in AVPV neurons by using an antibody that differentiates between CREB and pCREB. Steroids 131-138 cAMP responsive element binding protein 1 Rattus norvegicus 177-181 24882158-8 2014 Our study confirms in humans a preclinically suggested relation of the steroid hormones progesterone and DHEAS to 5-HT1A receptor binding. Steroids 71-87 sulfotransferase family 2A member 1 Homo sapiens 105-110 8622133-3 1996 Because the ability of CREB to activate transcription depends on phosphorylation at Ser133, we also evaluated the effects of acute steroid treatment on levels of phosphorylated CREB (pCREB) in AVPV neurons by using an antibody that differentiates between CREB and pCREB. Steroids 131-138 cAMP responsive element binding protein 1 Rattus norvegicus 177-181 8622133-7 1996 Double-labeling experiments showed that pCREB was colocalized with PDYN, PENK, or TH mRNA in the AVPV, suggesting that pCREB may mediate the effect of steroid hormones on gene expression in these neurons. Steroids 151-158 proenkephalin Rattus norvegicus 73-77 8602526-3 1996 A mutation of glutamate 204, which is absolutely required for the activity of human steroid reductase, abolishes the in vivo activity of DET2 and leads to defects in light-regulated development that can be ameliorated by application of a plant steroid, brassinolide. Steroids 84-91 3-oxo-5-alpha-steroid 4-dehydrogenase family protein Arabidopsis thaliana 137-141 24704289-3 2014 The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment. Steroids 142-149 C-C motif chemokine ligand 26 Homo sapiens 99-108 24704289-3 2014 The aim of this study was to evaluate changes in the cytokine expression profiles (IL-5, IL-13 and eotaxin-3/CCL26) in children after topical steroid treatment. Steroids 142-149 C-C motif chemokine ligand 26 Homo sapiens 109-114 24704289-8 2014 A significant reduction of the eosinophil infiltrate as well as of IL-5, IL-13 and eotaxin-3 mucosal profiles was observed after steroid treatment both at the proximal and distal oesophagus (p<0.0001). Steroids 129-136 C-C motif chemokine ligand 26 Homo sapiens 83-92 24937427-8 2014 Our findings demonstrate that in addition to reproduction, kisspeptin signaling influences BW, energy expenditure, and glucose homeostasis in a sexually dimorphic and partially sex steroid-independent manner; therefore, alterations in kisspeptin signaling might contribute, directly or indirectly, to some facets of human obesity, diabetes, or metabolic dysfunction. Steroids 181-188 KiSS-1 metastasis-suppressor Mus musculus 59-69 8620023-0 1996 Effects of free fatty acids on the binding of bovine and human serum albumin with steroid hormones. Steroids 82-98 albumin Bos taurus 63-76 8620023-2 1996 In this report, the effects of free fatty acids (FFA) on the binding of steroids to albumin were compared for the cases of bovine serum albumin (BSA) and human serum albumin (HSA). Steroids 72-80 albumin Bos taurus 130-149 8620023-4 1996 In the case of BSA, Ka for progesterone and testosterone increased upon binding of FFA (myristic, palmitic and stearic acid) to BSA and the maximum value of Ka for these steroids could be attained by 3--4 mol of FFA bound per mol BSA. Steroids 170-178 albumin Bos taurus 15-18 8620023-4 1996 In the case of BSA, Ka for progesterone and testosterone increased upon binding of FFA (myristic, palmitic and stearic acid) to BSA and the maximum value of Ka for these steroids could be attained by 3--4 mol of FFA bound per mol BSA. Steroids 170-178 albumin Bos taurus 128-131 24953190-2 2014 The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions. Steroids 156-171 steroid receptor RNA activator 1 Homo sapiens 4-32 22320241-1 2012 Early conversion to a calcineurin-inhibitor (CNI)-free maintenance immunosuppression with sirolimus (SRL), mycophenolate mofetil (MMF) and steroids was associated with an improved 1-year renal function as compared with a cyclosporine (CsA)-based regimen (SMART core-study). Steroids 139-147 calcineurin binding protein 1 Homo sapiens 22-43 8620023-4 1996 In the case of BSA, Ka for progesterone and testosterone increased upon binding of FFA (myristic, palmitic and stearic acid) to BSA and the maximum value of Ka for these steroids could be attained by 3--4 mol of FFA bound per mol BSA. Steroids 170-178 albumin Bos taurus 128-131 24953190-2 2014 The steroid receptor coactivator (SRC) family is composed of three homologous members (SRC-1, SRC-2, and SRC-3), which are uniquely important for mediating steroid hormone and mitogenic actions. Steroids 156-171 steroid receptor RNA activator 1 Homo sapiens 34-37 8620023-5 1996 Furthermore, the elution profiles of gel-filtration chromatography clearly showed that progesterone and testosterone are easily liberated from the steroid/BSA complexes and that FFA potentiates the binding of these steroids to BSA. Steroids 147-154 albumin Bos taurus 155-158 8620023-5 1996 Furthermore, the elution profiles of gel-filtration chromatography clearly showed that progesterone and testosterone are easily liberated from the steroid/BSA complexes and that FFA potentiates the binding of these steroids to BSA. Steroids 215-223 albumin Bos taurus 155-158 8620023-5 1996 Furthermore, the elution profiles of gel-filtration chromatography clearly showed that progesterone and testosterone are easily liberated from the steroid/BSA complexes and that FFA potentiates the binding of these steroids to BSA. Steroids 215-223 albumin Bos taurus 227-230 8637885-1 1996 Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. Steroids 120-127 gonadotropin releasing hormone 1 Rattus norvegicus 15-52 24509771-0 2014 Escherichia coli kduD encodes an oxidoreductase that converts both sugar and steroid substrates. Steroids 77-84 oxidoreductase Escherichia coli 33-47 24509771-1 2014 A previously unidentified oxidoreductase from Escherichia coli catalyzes the regioselective reduction of eukaryotic steroid hormone 11-deoxycorticosterone (11-DOC) to the valuable bioactive product 4-pregnen-20,21-diol-3-one. Steroids 116-131 oxidoreductase Escherichia coli 26-40 22776597-6 2012 In 44 inpatients, the blood EOS remained high before steroid treatment, and quickly returned to normal level after the disease became stable. Steroids 53-60 EOS Homo sapiens 28-31 22776597-7 2012 There was a linear correlation between EOS and steroid doses (Spearman analysis,r=0.496,P<0.001). Steroids 47-54 EOS Homo sapiens 39-42 22776597-8 2012 In 5 patients who were treated by non-steroid approach, EOS level also declined after the disease was resolved. Steroids 38-45 EOS Homo sapiens 56-59 8637885-1 1996 Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. Steroids 120-127 gonadotropin releasing hormone 1 Rattus norvegicus 54-59 22776597-9 2012 CONCLUSION: EOS can be one of useful indicators for the application of steroids in the treatment of BP. Steroids 71-79 EOS Homo sapiens 12-15 24648042-7 2014 High-dose steroids with anti-CD52 appeared to improve the response rate in 17p-/TP53 mutated cases and allogeneic transplantation achieved prolonged disease control irrespective of high-risk disease. Steroids 10-18 CD52 molecule Homo sapiens 29-33 8626436-0 1996 Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter. Steroids 43-58 kallikrein related peptidase 3 Homo sapiens 85-110 24929815-0 2014 Computational determination of binding structures and free energies of glucose 6-phosphate dehydrogenase with novel steroid inhibitors. Steroids 116-123 glucose-6-phosphate dehydrogenase Homo sapiens 71-104 24929815-3 2014 In the present study, we investigated the detailed binding modes and binding free energies for G6PD interacting with a promising series of recently developed inhibitors, i.e., the steroid derivatives, by performing molecular docking, molecular dynamics (MD) simulations, and binding free energy calculations. Steroids 180-187 glucose-6-phosphate dehydrogenase Homo sapiens 95-99 22487281-13 2012 CONCLUSION: In this study, significant up-regulation of SP-A and SP-D was revealed in patients with CRSwNP after systemic steroid treatment. Steroids 122-129 surfactant protein D Homo sapiens 65-69 8900593-4 1996 Upon dimerization with BmCF1, the silkmoth homology of DmUSP, BmEcR binds the radiolabeled steroid ligand 125I-iodoponasterone A with Kd = 1.1 nM, indistinguishable from that exhibited by DmEcR/DmUSP. Steroids 91-98 protein ultraspiracle homolog Bombyx mori 23-28 23877834-1 2014 Selective serotonin reuptake inhibitors, tricyclic antidepressants, various psychoactive drugs, as well as endogenous steroids and cannabinoid-like compounds are metabolized by the polymorphic cytochrome P450 2C19 (CYP2C19). Steroids 118-126 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 215-222 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Steroids 12-19 progesterone receptor Mus musculus 53-74 22155565-1 2012 The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial-stromal cell communication, which is critical for its development and function. Steroids 12-19 progesterone receptor Mus musculus 76-78 8728316-1 1996 A variety of amphiphiles inhibit plasma membrane cholesterol esterification and induce 3-hydroxy-3-methylglutaryl-coenzyme A reductase accumulation in cultured cells; among these are steroids, hydrophobic amines, phenothiazines, ionophores, colchicine, and lysophosphatides. Steroids 183-191 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 87-134 8648917-7 1996 Moreover, elevated urinary MCAF levels were dramatically decreased during steroid therapy-induced convalescence in 29 patients examined serially (13.9 +/- 4.5 vs. 5.3 +/- 1.7 pg/ml . Steroids 74-81 C-C motif chemokine ligand 2 Homo sapiens 27-31 22155228-7 2012 Thus, chemical-induced alterations in serum adiponectin concentrations have implication for steroid hormone secretion. Steroids 92-107 adiponectin, C1Q and collagen domain containing Rattus norvegicus 44-55 24516177-5 2014 Hence, in this study, we studied the expression of PARP1 in the uterus during embryo implantation and decidualisation, and its regulation by ovarian steroids. Steroids 149-157 poly (ADP-ribose) polymerase family, member 1 Mus musculus 51-56 24564399-7 2014 Expression of 2 other DEHP targets, hormone-sensitive lipase and phosphoenolpyruvate carboxykinase 1 (Pck1), correlated with reduced aldosterone levels and may account for the inhibitory effect of DEHP on adrenal steroid formation. Steroids 213-220 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 102-106 8835120-5 1996 RESULTS: We found that the capacity for expression of IL-3 and GM-CSF was significantly higher in acute asthmatics prior to steroid treatment (n = 24) than those in stable disease (n = 38) and healthy subjects (n = 32, P < 0.001 for IL-3 and < 0.05 for GM-CSF), but no difference was observed between the latter two groups. Steroids 124-131 interleukin 3 Homo sapiens 54-58 24583150-7 2014 The levels of serum IL-17A and IFN-gamma in steroid group and serum TNF-alpha in alcoholic group were significantly higher than those in the HC. Steroids 44-51 interleukin 17A Homo sapiens 20-26 22113624-8 2012 Furthermore, human NSDHL protein and mouse Nsdhl mRNA were expressed in tissues synthesizing cholesterol and steroids and in all peripheral tissues affected by CHILD or CK syndromes. Steroids 109-117 NAD(P) dependent steroid dehydrogenase-like Homo sapiens 19-24 8835120-5 1996 RESULTS: We found that the capacity for expression of IL-3 and GM-CSF was significantly higher in acute asthmatics prior to steroid treatment (n = 24) than those in stable disease (n = 38) and healthy subjects (n = 32, P < 0.001 for IL-3 and < 0.05 for GM-CSF), but no difference was observed between the latter two groups. Steroids 124-131 colony stimulating factor 2 Homo sapiens 63-69 8835120-6 1996 Further assessment made in 15 of the 24 acute asthmatics 7 days after systemic steroid treatment revealed a significant reduction in GM-CSF expression (P < 0.05) but not for IL-3. Steroids 79-86 colony stimulating factor 2 Homo sapiens 133-139 8835125-7 1996 CONCLUSION: The close association of Fel d I protein with skin sebaceous glands and anal sacs both with holocrine function and lipids" secretions in one hand, and the homology of chain I of Fel d I with some steroid-binding proteins in other hand, suggest a possible physiological role for Fel d I in the regulation of lipids on skin and cat fur. Steroids 208-215 major allergen I polypeptide chain 2 Felis catus 190-197 24482023-10 2014 IL-17 immunostaining correlated with proteinuria, requirement for pulse steroids, and SLEDAI renal score, and negatively with GFR. Steroids 72-80 interleukin 17A Homo sapiens 0-5 8835125-7 1996 CONCLUSION: The close association of Fel d I protein with skin sebaceous glands and anal sacs both with holocrine function and lipids" secretions in one hand, and the homology of chain I of Fel d I with some steroid-binding proteins in other hand, suggest a possible physiological role for Fel d I in the regulation of lipids on skin and cat fur. Steroids 208-215 major allergen I polypeptide chain 2 Felis catus 190-197 9053775-2 1996 In female rats, NPY facilitation of LHRH release is greatly augmented in advance of preovulatory LHRH surges, likely via the actions of ovarian steroids. Steroids 144-152 gonadotropin releasing hormone 1 Rattus norvegicus 36-40 24758565-6 2014 RESULTS: We identified three potential biomarkers CD163, TSP-1 and IL-1RII whose response to steroids was significantly enhanced when DIMS0150 was applied. Steroids 93-101 CD163 molecule Homo sapiens 50-55 9053775-11 1996 These results demonstrate that NPY stimulates LHRH release from the hypothalamus in vitro, and that gonadal steroids, in this case T and/or its metabolites, modulate the responsiveness of the LHRH neuron to NPY. Steroids 108-116 gonadotropin releasing hormone 1 Rattus norvegicus 192-196 24508592-3 2014 We have previously shown that OHPCBs interact with human hydroxysteroid sulfotransferase hSULT2A1, an enzyme that catalyzes the sulfation of dehydroepiandrosterone (DHEA), other alcohol-containing steroids, bile acids, and many xenobiotics. Steroids 197-205 sulfotransferase family 2A member 1 Homo sapiens 89-97 8731325-1 1996 The most common enzymatic defect of steroid synthesis is deficiency of the adrenal steroid 21-hydroxylase. Steroids 36-43 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 83-105 24369117-9 2014 In summary, these data demonstrate that DGKtheta plays an important role in steroid hormone production in human adrenocortical cells. Steroids 76-91 diacylglycerol kinase theta Homo sapiens 40-48 8706045-3 1996 We have now identified the p65 gene as a novel member of the superfamily of genes that encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid, and thyroid hormones. Steroids 152-160 golgi reassembly stacking protein 1 Homo sapiens 27-30 24492894-1 2014 Sulfotransferase (SULT) 2A1 catalyzes sulfonation of drugs and endogenous compounds and plays an important role in xenobiotic metabolism as well as in the maintenance of steroid and lipid homeostasis. Steroids 170-177 sulfotransferase family 2A member 1 Homo sapiens 0-27 8950614-7 1996 In vivo, sex steroids affect IGF-I levels in the endocrine hypothalamus. Steroids 13-21 insulin-like growth factor 1 Rattus norvegicus 29-34 24618699-14 2014 Chronic CD8(+) T-cell expansions with organ infiltration in immunocompromised patients may involve other organs than parotid glands; they are non clonal and of favorable outcome after correction of the immune deficiency and/or steroids. Steroids 227-235 CD8a molecule Homo sapiens 8-11 24510055-11 2014 In conclusion, Pravastatin may prevent steroid-induced ONFH by suppressing PPARgamma expression and activating Wnt signaling pathway. Steroids 39-46 peroxisome proliferator-activated receptor gamma Rattus norvegicus 75-84 8950614-8 1996 IGF-I levels in tanycytes, a specific subtype of glial cells present in the arcuate nucleus and median eminence, are sexually dimorphic in the rat, increase with the onset of puberty, and are regulated by perinatal and adult levels of sex steroids. Steroids 239-247 insulin-like growth factor 1 Rattus norvegicus 0-5 24586990-0 2014 Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones. Steroids 88-104 sulfotransferase family 2A member 1 Homo sapiens 32-37 24586990-1 2014 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid in human, with the highest concentrations between age 20 and 30, but displaying a significant decrease with age. Steroids 72-79 sulfotransferase family 2A member 1 Homo sapiens 32-37 24586990-4 2014 In this study, the role of DHEAS on the first and rate-limiting step of steroid hormone biosynthesis was analyzed in a reconstituted in vitro system, consisting of purified CYP11A1, adrenodoxin and adrenodoxin reductase. Steroids 72-87 sulfotransferase family 2A member 1 Homo sapiens 27-32 24586990-10 2014 These findings indicate that DHEAS affects steroid hormone biosynthesis on a molecular level resulting in an increased formation of pregnenolone. Steroids 43-58 sulfotransferase family 2A member 1 Homo sapiens 29-34 24239983-2 2014 Here, the role of GPER-1 in murine renal tissue was further evaluated by examining its anatomical distribution, subcellular distribution and steroid binding specificity. Steroids 141-148 G protein-coupled estrogen receptor 1 Mus musculus 18-24 24498408-1 2014 The female steroid, 17beta-estradiol (E2), is important for pancreatic beta-cell function and acts via at least three estrogen receptors (ER), ERalpha, ERbeta, and the G-protein coupled ER (GPER). Steroids 11-18 G protein-coupled estrogen receptor 1 Mus musculus 168-188 24498408-1 2014 The female steroid, 17beta-estradiol (E2), is important for pancreatic beta-cell function and acts via at least three estrogen receptors (ER), ERalpha, ERbeta, and the G-protein coupled ER (GPER). Steroids 11-18 G protein-coupled estrogen receptor 1 Mus musculus 190-194 24286569-10 2014 INTERPRETATION: This is the first study to indicate that patients who received a greater number of local steroid injections preoperatively were more likely to have postoperative complaints associated with CTS. Steroids 105-112 transthyretin Homo sapiens 205-208 24077066-1 2014 The main fast-acting inhibitory receptors in the mammalian brain are gamma-aminobutyric acid type-A (GABAA) receptors for which neurosteroids, a subclass of steroids synthesized de novo in the brain, constitute a group of endogenous ligands with the most potent positive modulatory actions known. Steroids 133-141 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 101-106 24075909-1 2014 The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is essential for the biosynthesis of all active steroid hormones, such as those secreted from the adrenal gland, testis, ovary, skin and placenta. Steroids 116-132 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 57-66 24446294-6 2014 Moreover, the relative OVA expression level in pigeon oviduct epithelial cells could be upregulated by a constant concentration of steroid hormones. Steroids 131-147 ovalbumin (SERPINB14) Gallus gallus 23-26 25073521-3 2014 Whether Fmr-1 gene expression is regulated by sex steroid hormones as a function of age is not known. Steroids 50-66 fragile X messenger ribonucleoprotein 1 Mus musculus 8-13 24292869-11 2014 Analysis of the expression levels of steroid-metabolizing enzymes revealed positive correlations between SRD5A1 and HSD3B1, and STS and HSD17B1. Steroids 37-44 steroid 5 alpha-reductase 1 Homo sapiens 105-111 24292869-11 2014 Analysis of the expression levels of steroid-metabolizing enzymes revealed positive correlations between SRD5A1 and HSD3B1, and STS and HSD17B1. Steroids 37-44 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 116-122 24219001-6 2014 In this review, we will focus on the effect of the newly appreciated cardiotonic steroids (CTS)-Na/K-ATPase signaling on RPT-mediated sodium handling by coordinated regulation of the Na/K-ATPase and sodium/proton exchanger isoform 3 (NHE3). Steroids 81-89 solute carrier family 9 member A3 Homo sapiens 234-238 25495567-8 2014 However, TSPO has many proposed functions and can also increase steroid synthesis, which leads to inhibition of inflammation and inhibition of the release of apoptotic factors, thereby decreasing cell damage and promoting cell survival. Steroids 64-71 translocator protein Homo sapiens 9-13 24364584-0 2014 The role of PBR/TSPO in steroid biosynthesis challenged. Steroids 24-31 translocator protein Homo sapiens 12-15 24364584-0 2014 The role of PBR/TSPO in steroid biosynthesis challenged. Steroids 24-31 translocator protein Homo sapiens 16-20 24364587-0 2014 On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis. Steroids 57-72 translocator protein Homo sapiens 19-47 24364587-0 2014 On the role of the translocator protein (18-kDa) TSPO in steroid hormone biosynthesis. Steroids 57-72 translocator protein Homo sapiens 49-53 24188886-0 2014 GPCR-mediated rapid, non-genomic actions of steroids: comparisons between DmDopEcR and GPER1 (GPR30). Steroids 44-52 Octopamine receptor in mushroom bodies Drosophila melanogaster 0-4 24169237-3 2014 Small compounds, TTR stabilizers (usually non-steroid anti-inflammatory drugs), bind to the thyroxine (T4) central binding channel, increasing TTR tetrameric stability and TTR/Abeta interaction. Steroids 46-53 transthyretin Mus musculus 17-20 25007867-11 2014 Collectively, these results indicate that REV-ERBalpha plays an inhibitory role in the expression of PTGS2 in both bovine USCs and UECs treated with ovarian steroids. Steroids 157-165 prostaglandin-endoperoxide synthase 2 Bos taurus 101-106 23902478-5 2013 G-Protein oestrogen receptor (GPER) is a recently recognized G-protein coupled receptor (GPCR) that is activated by steroid hormones. Steroids 116-132 G protein-coupled estrogen receptor 1 Homo sapiens 0-28 23902478-5 2013 G-Protein oestrogen receptor (GPER) is a recently recognized G-protein coupled receptor (GPCR) that is activated by steroid hormones. Steroids 116-132 G protein-coupled estrogen receptor 1 Homo sapiens 30-34 24200615-4 2013 Recent studies have shown that steroid-mediated induction of ubiquitin ligases (atrogin-1, muscle RING finger-1) and suppression of mammalian/mechanistic target of rapamycin cause an imbalance between anabolism and catabolism of muscle proteins, resulting in muscle atrophy. Steroids 31-38 F-box protein 32 Homo sapiens 80-89 23928325-6 2013 The enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) produces the precursor for A and P, and its activity is regulated by steroids. Steroids 127-135 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-45 23928325-6 2013 The enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) produces the precursor for A and P, and its activity is regulated by steroids. Steroids 127-135 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 47-56 23928325-13 2013 All steroids prevented MAP 2c decrease in both brain regions. Steroids 4-12 microtubule associated protein 2 Homo sapiens 23-29 23792783-8 2013 Both hormones selectively prevented the induction of pro-inflammatory iNOS, interleukin IL-1ss, and chemokine ligand CCL5, whereas anti-inflammatory IL-10 and protective TREM 2 were up-regulated by sex steroids. Steroids 202-210 triggering receptor expressed on myeloid cells 2 Mus musculus 170-176 24231487-3 2013 We report a child aged 4 months with steroid-resistant NS who had polymorphism of NPHS1 (E117K) and mutation of NPHS2 (P118L). Steroids 37-44 NPHS1 adhesion molecule, nephrin Homo sapiens 82-87 25206601-9 2013 We thus hypothesize that Abeta-mediated cognitive deficits may occur via changes in neuroactive steroids. Steroids 96-104 amyloid beta precursor protein Rattus norvegicus 25-30 23941873-8 2013 The effects of GHR-null mutations on glucose control, responses to dietary interventions, steroid metabolism, detoxification pathways, and lifespan may depend on a mixture of direct hepatic effects and cross talk between different GH-responsive tissues. Steroids 90-97 growth hormone receptor Homo sapiens 15-18 23913445-1 2013 In the last two decades, sensory neurons and Schwann cells in the dorsal root ganglia (DRG) were shown to express the rate-limiting enzyme of the steroid synthesis, cytochrome P450 side-chain cleavage enzyme (P450scc), as well as the key enzyme of progesterone synthesis, 3beta-hydroxysteroid dehydrogenase (3beta-HSD). Steroids 146-153 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 272-306 23913445-1 2013 In the last two decades, sensory neurons and Schwann cells in the dorsal root ganglia (DRG) were shown to express the rate-limiting enzyme of the steroid synthesis, cytochrome P450 side-chain cleavage enzyme (P450scc), as well as the key enzyme of progesterone synthesis, 3beta-hydroxysteroid dehydrogenase (3beta-HSD). Steroids 146-153 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 308-317 23572423-1 2013 The aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. Steroids 192-208 runt related transcription factor 3 Mus musculus 87-122 23572423-1 2013 The aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. Steroids 192-208 runt related transcription factor 3 Mus musculus 124-129 24026316-1 2013 BACKGROUND: Steroid injections are used in idiopathic carpal tunnel syndrome (CTS), but evidence of efficacy beyond 1 month is lacking. Steroids 12-19 transthyretin Homo sapiens 78-81 23357651-7 2013 Recently, we identified the steroid hormone 17beta-estradiol (E2) as an endogenous modulator of NGB levels in neuroblastoma SK-N-BE cell line. Steroids 28-43 neuroglobin Homo sapiens 96-99 24498843-10 2013 Mutations in NPHS1 gene could occur in both SRNS and SSNS patients; however, considering higher incidence of heterozygous mutations in SSNS, the existence of milder phenotype in these cases would be the reason for steroid response. Steroids 214-221 NPHS1 adhesion molecule, nephrin Homo sapiens 13-18 23744640-1 2013 In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei (anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and arcuate nucleus [ARC]) and modulated by sex steroids. Steroids 219-227 KiSS-1 metastasis-suppressor Mus musculus 12-22 23394253-4 2013 Steroid production and its dependency on FSHR genotype were also assessed. Steroids 0-7 follicle stimulating hormone receptor Homo sapiens 41-45 23620397-9 2013 Treatment with steroids resulted in complete remission of the nephrotic syndrome, normalization of serum LCAT activity and HDL level, and disappearance of foam cell accumulation in renal tissue. Steroids 15-23 lecithin-cholesterol acyltransferase Homo sapiens 105-109 24466755-0 2013 [Dose-response effect of steroid hormones on the Gfi1 and U2afil4 gene expression in T lymphocytes at different stages of differentiation]. Steroids 25-41 growth factor independent 1 transcriptional repressor Homo sapiens 49-53 24466755-5 2013 We have shown that steroid hormones have different effects on U2af1l4 and Gfi1 transcription regulation in dissimilar differentiation stage cell culture, subjected to antigen-independent stimulation. Steroids 19-26 U2 small nuclear RNA auxiliary factor 1 like 4 Homo sapiens 62-69 24466755-5 2013 We have shown that steroid hormones have different effects on U2af1l4 and Gfi1 transcription regulation in dissimilar differentiation stage cell culture, subjected to antigen-independent stimulation. Steroids 19-26 growth factor independent 1 transcriptional repressor Homo sapiens 74-78 23660487-3 2013 In the adult, Kiss1 gene expression occurs in two hypothalamic nuclei, namely the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC), which are differentially regulated by peripheral sex steroid hormones. Steroids 211-227 KiSS-1 metastasis-suppressor Rattus norvegicus 14-19 23804103-3 2013 We examined here whether gonadal steroids modulated the excitability of kisspeptin neurons located in the rostral periventricular region of the third ventricle (RP3V) of female mice. Steroids 33-41 KiSS-1 metastasis-suppressor Mus musculus 72-82 23649620-6 2013 Nandrolone, an anabolic steroid, has been shown to inhibit Notch signaling and up-regulate Numb, a Notch inhibitor. Steroids 24-31 NUMB endocytic adaptor protein Homo sapiens 91-95 23022538-6 2013 One mechanism that shows great promise is to study the interplay of BDNF and glucocorticoid hormones, a major class of natural steroid secreted during stress reactions and in synchrony with circadian rhythms. Steroids 127-134 brain derived neurotrophic factor Homo sapiens 68-72 23123886-1 2013 Interaction between steroid sex hormones and brain-derived neurotrophic factor (BDNF) is a common feature of vertebrate brain organization. Steroids 20-27 brain derived neurotrophic factor Homo sapiens 45-78 23123886-1 2013 Interaction between steroid sex hormones and brain-derived neurotrophic factor (BDNF) is a common feature of vertebrate brain organization. Steroids 20-27 brain derived neurotrophic factor Homo sapiens 80-84 23123886-3 2013 Testosterone (T) and its steroid metabolites interact with BDNF during development of the song system and in adult plasticity, including the addition of newborn neurons to the pallial nucleus HVC and seasonal changes in structure and function of these circuits. Steroids 25-32 brain derived neurotrophic factor Homo sapiens 59-63 23123886-6 2013 The interaction between sex steroids and BDNF is an example of molecular exploitation, with the evolutionarily ancient steroid-receptor complex having been captured by the more recently evolved BDNF. Steroids 28-36 brain derived neurotrophic factor Homo sapiens 41-45 23123886-6 2013 The interaction between sex steroids and BDNF is an example of molecular exploitation, with the evolutionarily ancient steroid-receptor complex having been captured by the more recently evolved BDNF. Steroids 28-36 brain derived neurotrophic factor Homo sapiens 194-198 23123886-7 2013 The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin in sexually dimorphic and reproductively relevant contexts. Steroids 30-38 brain derived neurotrophic factor Homo sapiens 42-46 23123886-7 2013 The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin in sexually dimorphic and reproductively relevant contexts. Steroids 30-38 brain derived neurotrophic factor Homo sapiens 113-125 23164677-0 2013 Introduction to "steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)". Steroids 17-32 brain derived neurotrophic factor Homo sapiens 65-98 21246373-1 2012 The IGF-IR density on CD4+T-lymphocytes was studied using flow cytometry in 40 early steroid- and DMARD-naive rheumatoid arthritis (RA) patients before and after 52 weeks of treatment with methotrexate+placebo or methotrexate+cyclosporine A and in 15 controls. Steroids 85-92 insulin like growth factor 1 receptor Homo sapiens 4-10 22179700-1 2012 Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Steroids 28-44 vitamin D receptor Homo sapiens 154-157 22179700-1 2012 Transcription regulation by steroid hormones and other metabolites is mediated by nuclear receptors (NRs) such as the vitamin D and retinoid X receptors (VDR and RXR). Steroids 28-44 retinoid X receptor alpha Homo sapiens 162-165 21917270-4 2012 Although there have been only a few reports similar to our case, the present case suggests a close relationship between the positive serum anti-AQP4 antibody and symmetrical hypothalamic lesions with hypersomnolence and without optic /spinal lesion, which is improved by steroid treatment. Steroids 271-278 aquaporin 4 Homo sapiens 144-148 22102282-3 2012 The evolutionary conserved Mediator complex plays a key coregulatory role in steroid hormone-dependent transcription and is chiefly targeted to NRs via the LXXLL-containing MED1 subunit. Steroids 77-92 mediator complex subunit 1 Homo sapiens 173-177 25954555-2 2012 This case is noteworthy for a significant increase in circulating CD56(bright)CD16- cytokine-producing NK cells after treatment with steroids for skin rash. Steroids 133-141 Fc gamma receptor IIIa Homo sapiens 78-82 23097745-2 2012 Physical association of hOSTalpha and beta subunits is essential for their polarized basolateral plasma membrane localization and function in the export of bile acids and steroids. Steroids 171-179 solute carrier family 51 subunit alpha Homo sapiens 24-42 22259225-1 2012 PURPOSE: To evaluate the level of matrix metalloproteinase (MMP)-2 and MMP-9 activities in patients with steroid induced posterior subcapsular cataract (PSC). Steroids 105-112 matrix metallopeptidase 9 Homo sapiens 71-76 22259225-8 2012 RESULTS: The level of MMP-2 and MMP-9 activity was found to be high in LECs and serum of cases with steroid induced PSC. Steroids 100-107 matrix metallopeptidase 9 Homo sapiens 32-37 22259225-9 2012 Further in all steroid induced cases, a 1.4 fold increase was observed in MMP-2 activity in LECs and a 1.4 fold increase in MMP-9 activity in the serum. Steroids 15-22 matrix metallopeptidase 9 Homo sapiens 124-129 22259225-11 2012 CONCLUSIONS: MMP-2 and MMP-9 activity in both LECs and serum was significantly higher in cases with steroid induced PSC. Steroids 100-107 matrix metallopeptidase 9 Homo sapiens 23-28 22259225-12 2012 The possible use of MMP-9 as a non-invasive biomarker in ascertaining the presence of steroid induced PSC should be evaluated using a larger sample size. Steroids 86-93 matrix metallopeptidase 9 Homo sapiens 20-25 23071783-1 2012 Several endocrine factors, including sex-steroid hormones are known to influence adiponectin secretion. Steroids 41-48 adiponectin, C1Q and collagen domain containing Rattus norvegicus 81-92 23029265-7 2012 Moreover, Mfn2 knockdown is sufficient to impair steroid biosynthesis. Steroids 49-56 mitofusin 2 Homo sapiens 10-14 22457708-1 2012 GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, and suppress the immune system through the glucocorticoid receptor (GR). Steroids 20-27 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 246-269 22457708-1 2012 GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase), a key enzyme of gluconeogenesis, and suppress the immune system through the glucocorticoid receptor (GR). Steroids 20-27 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 271-273 21801808-7 2011 The 1,25-(OH)(2)D(3) catabolizing hydroxylase CYP24A1 is increasingly expressed during colon cancer progression, indicating that colonocytes are released from normal growth control by the steroid hormone. Steroids 188-203 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 46-53 21681500-4 2011 We started steroid therapy in two cases with IL-18 values greater than 1000 pg/ml without being aware of IL-18 levels. Steroids 11-18 interleukin 18 Homo sapiens 45-50 21681500-7 2011 Patients with elevated levels of LDH are likely to have significantly elevated IL-18 values (>=1000 pg/ml) and thus can be candidates for steroid therapy. Steroids 141-148 interleukin 18 Homo sapiens 79-84 21720805-2 2011 In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n = 18, median age 5) and focal segmental glomerulosclerosis (FSGS, n = 16, median age 15). Steroids 144-151 matrix metallopeptidase 9 Homo sapiens 52-57 21720805-2 2011 In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n = 18, median age 5) and focal segmental glomerulosclerosis (FSGS, n = 16, median age 15). Steroids 144-151 TIMP metallopeptidase inhibitor 2 Homo sapiens 119-125 21764589-1 2011 Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Steroids 12-19 cathepsin B Homo sapiens 91-102 22001574-9 2011 Thus, IFs can modulate the hypothalamic OXT neurons and the effects are site-specific and sexually dimorphic, suggesting that neonatal exposure to IFs may modify such a steroid-dependent development of particular neural pathways, including OXT system. Steroids 169-176 oxytocin Mus musculus 40-43 22001574-9 2011 Thus, IFs can modulate the hypothalamic OXT neurons and the effects are site-specific and sexually dimorphic, suggesting that neonatal exposure to IFs may modify such a steroid-dependent development of particular neural pathways, including OXT system. Steroids 169-176 oxytocin Mus musculus 240-243 21764896-7 2011 We also illustrate the basic aspects of the expression, localization, function, and regulation of the GR by steroid hormones (androgens and glucocorticoids) within the epididymis. Steroids 110-126 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 103-105 24683427-2 2011 The major sulfotransferase (SULT) isoforms that conjugate steroids in humans are SULT1E1, SULT2A1, and SULT2B1b. Steroids 58-66 sulfotransferase family 2A member 1 Homo sapiens 90-97 21323755-3 2011 This study aimed to determine the effect of sex steroids on the plasma profiles of GH, IGF-I and insulin and their receptors in the liver and adipose tissues of dairy cows. Steroids 48-56 growth hormone receptor Bos taurus 83-85 21768169-7 2011 DNA affinity immunoblotting and chromatin immunoprecipitation assay revealed that CAR ligand enhanced the recruitment of the gluconeogenic transcription factors, forkhead box O1 (FOXO1) and hepatocyte nuclear factor 4alpha (HNF4alpha), but sex steroids suppressed these recruitments on the CAR responsive element. Steroids 244-252 hepatic nuclear factor 4, alpha Mus musculus 190-222 21768169-7 2011 DNA affinity immunoblotting and chromatin immunoprecipitation assay revealed that CAR ligand enhanced the recruitment of the gluconeogenic transcription factors, forkhead box O1 (FOXO1) and hepatocyte nuclear factor 4alpha (HNF4alpha), but sex steroids suppressed these recruitments on the CAR responsive element. Steroids 244-252 hepatic nuclear factor 4, alpha Mus musculus 224-233 23717070-0 2011 Korean Red Ginseng Up-regulates C21-Steroid Hormone Metabolism via Cyp11a1 Gene in Senescent Rat Testes. Steroids 36-51 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 67-74 23717070-9 2011 Ingenuity Pathway Analysis of untreated aged rats versus aged rats treated with KRG showed that the affected most was Cyp11a1, responsible for C21-steroid hormone metabolism, and the top molecular and cellular functions are organ morphology and reproductive system development and function. Steroids 147-162 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 118-125 23164677-0 2013 Introduction to "steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)". Steroids 17-32 brain derived neurotrophic factor Homo sapiens 100-104 23211562-6 2013 Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but also in mechanisms of signaling associated with it. Steroids 168-176 brain derived neurotrophic factor Homo sapiens 90-94 23211562-6 2013 Additional studies have also documented regulation of the expression of the high-affinity BDNF receptor Tropomyosin-Related Kinase B by estradiol, thus implicating sex steroids not only in the regulation of BDNF expression, but also in mechanisms of signaling associated with it. Steroids 168-176 brain derived neurotrophic factor Homo sapiens 207-211 23898489-0 2013 Important role of the C-terminal region of pig aldo-keto reductase family 1 member C1 in the NADPH-dependent reduction of steroid hormones. Steroids 122-138 aldo-keto reductase family 1 member C1 Sus scrofa 47-85 20447949-9 2011 Seven patients (7.8%) experienced a HSR requiring a treatment intervention (fluid bolus, oxygen, steroid, and/or diphenhydramine). Steroids 97-104 HSR Homo sapiens 36-39 8645607-0 1996 Dual regulation of the epidermal growth factor family of growth factors in breast cancer by sex steroids and protein kinase C. There has been increased interest in the last few years in seeking a better understanding of the local regulation of polypeptide growth factors by systemic hormones, such as sex steroids and by polypeptide hormones. Steroids 96-104 epidermal growth factor Homo sapiens 23-46 8645607-0 1996 Dual regulation of the epidermal growth factor family of growth factors in breast cancer by sex steroids and protein kinase C. There has been increased interest in the last few years in seeking a better understanding of the local regulation of polypeptide growth factors by systemic hormones, such as sex steroids and by polypeptide hormones. Steroids 305-313 epidermal growth factor Homo sapiens 23-46 21553154-9 2011 High CD68 expression (x >= 23%) and high CD163 expression (x >= 22%) within stromal cells of the lamina propria was significantly associated with steroid use (CD68, p = 0.012 and CD163, p = 0.004, respectively) and complicated sigmoid diverticulitis with severe inflammation (CD68, p = 0.0001 and CD163, p = 0.001, respectively). Steroids 152-159 CD68 molecule Homo sapiens 5-9 21553154-9 2011 High CD68 expression (x >= 23%) and high CD163 expression (x >= 22%) within stromal cells of the lamina propria was significantly associated with steroid use (CD68, p = 0.012 and CD163, p = 0.004, respectively) and complicated sigmoid diverticulitis with severe inflammation (CD68, p = 0.0001 and CD163, p = 0.001, respectively). Steroids 152-159 CD163 molecule Homo sapiens 44-49 8645607-2 1996 In this review, we discuss the regulation of members of the epidermal growth factor (EGF) family by sex steroids and by regulators of the polypeptide hormone signal transduction enzyme termed protein kinase C (PKC). Steroids 104-112 epidermal growth factor Homo sapiens 60-83 21553154-9 2011 High CD68 expression (x >= 23%) and high CD163 expression (x >= 22%) within stromal cells of the lamina propria was significantly associated with steroid use (CD68, p = 0.012 and CD163, p = 0.004, respectively) and complicated sigmoid diverticulitis with severe inflammation (CD68, p = 0.0001 and CD163, p = 0.001, respectively). Steroids 152-159 CD163 molecule Homo sapiens 185-190 21553154-9 2011 High CD68 expression (x >= 23%) and high CD163 expression (x >= 22%) within stromal cells of the lamina propria was significantly associated with steroid use (CD68, p = 0.012 and CD163, p = 0.004, respectively) and complicated sigmoid diverticulitis with severe inflammation (CD68, p = 0.0001 and CD163, p = 0.001, respectively). Steroids 152-159 CD163 molecule Homo sapiens 185-190 23665907-8 2013 In addition, the steroid dexamethasone and TGF-beta suppressed CXCL1 release through a transcriptional regulation. Steroids 17-24 C-X-C motif chemokine ligand 1 Homo sapiens 63-68 8645607-2 1996 In this review, we discuss the regulation of members of the epidermal growth factor (EGF) family by sex steroids and by regulators of the polypeptide hormone signal transduction enzyme termed protein kinase C (PKC). Steroids 104-112 epidermal growth factor Homo sapiens 85-88 23435367-1 2013 Ferredoxin 1 (FDX1; adrenodoxin) is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues. Steroids 118-133 ferredoxin 1 Homo sapiens 0-12 23435367-1 2013 Ferredoxin 1 (FDX1; adrenodoxin) is an iron-sulfur protein that is involved in various metabolic processes, including steroid hormone synthesis in mammalian tissues. Steroids 118-133 ferredoxin 1 Homo sapiens 14-18 21553154-10 2011 CONCLUSIONS: Inflammation, especially mediated by activated (CD68+/CD163+) macrophages in histopathological specimen might resemble the cellular link between steroid use and complicated types of sigmoid diverticulitis. Steroids 158-165 CD68 molecule Homo sapiens 61-65 21553154-10 2011 CONCLUSIONS: Inflammation, especially mediated by activated (CD68+/CD163+) macrophages in histopathological specimen might resemble the cellular link between steroid use and complicated types of sigmoid diverticulitis. Steroids 158-165 CD163 molecule Homo sapiens 67-72 8597430-0 1995 Regulation of placental corticotropin-releasing hormone by steroids. Steroids 59-67 corticotropin releasing hormone Homo sapiens 24-55 21410660-10 2011 The duration of steroid administration was negatively correlated with MMP-1, MMP-2, MMP-7, MMP-10, MMP-12, MMP-19, MMP-23 and TIMP-1 levels (P < 0 05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs. Steroids 16-23 matrix metallopeptidase 10 Homo sapiens 91-97 21410660-10 2011 The duration of steroid administration was negatively correlated with MMP-1, MMP-2, MMP-7, MMP-10, MMP-12, MMP-19, MMP-23 and TIMP-1 levels (P < 0 05), suggesting a suppressive effect of steroids on the expressions of MMPs and TIMPs. Steroids 16-23 matrix metallopeptidase 12 Homo sapiens 99-105 23401274-0 2013 Steroid-independent upregulation of matrix metalloproteinase 9 in chronic rhinosinusitis patients with radiographic evidence of osteitis. Steroids 0-7 matrix metallopeptidase 9 Homo sapiens 36-62 23638144-3 2013 Here, by using medaka whose kisspeptin (kiss1) neurons have been clearly demonstrated to be regulated by sex steroids, we analyzed the anatomical distribution of kisspeptin receptors Gpr54-1 and Gpr54-2. Steroids 109-117 metastasis-suppressor KiSS-1 Oryzias latipes 40-45 8822445-10 1995 Gonadal steroid inhibition by IL-1 alpha and IL-1 beta was not mediated through cytotoxic or antiproliferative effects on granulosa cells. Steroids 8-15 interleukin 1 alpha Homo sapiens 30-40 23550157-3 2013 Here, we show that the cytoplasmic RISC proteins PACT, TRBP, and Dicer are steroid receptor RNA activator (SRA) binding NR coregulators that target steroid-responsive promoters and regulate NR activity and downstream gene expression. Steroids 75-82 steroid receptor RNA activator 1 Homo sapiens 107-110 21306583-1 2011 BACKGROUND AND PURPOSE: Steroids prevent and reverse salbutamol-induced beta(2)-adrenoceptor tolerance in human small airways. Steroids 24-32 adrenoceptor beta 2 Homo sapiens 72-92 21306583-12 2011 Budesonide protection against beta(2)-adrenoceptor tolerance was correlated with the retention of receptor fluorescence on the plasma membrane, thereby suggesting a mechanism by which steroids alter beta(2)-adrenoceptor function. Steroids 184-192 adrenoceptor beta 2 Homo sapiens 30-50 21306583-12 2011 Budesonide protection against beta(2)-adrenoceptor tolerance was correlated with the retention of receptor fluorescence on the plasma membrane, thereby suggesting a mechanism by which steroids alter beta(2)-adrenoceptor function. Steroids 184-192 adrenoceptor beta 2 Homo sapiens 199-219 21454403-9 2011 Furthermore, MMP2 and MMP9 appear to regulate LH-induced steroidogenesis in mouse ovarian follicles, because a specific MMP2/9 inhibitor as well as the MMP2/9 inhibitor doxycycline suppress LH-induced follicular steroid production in vitro. Steroids 57-64 matrix metallopeptidase 2 Mus musculus 13-17 23333920-8 2013 Our results demonstrated that IL-27 induced and synergized with TNF-alpha to up-regulate CXCL10 mRNA and protein concentrations in a steroid-insensitive manner. Steroids 133-140 C-X-C motif chemokine ligand 10 Homo sapiens 89-95 8822445-11 1995 Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies. Steroids 105-112 interleukin 1 alpha Homo sapiens 46-56 21591266-0 2011 Discovery and initial validation of alpha 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Steroids 122-129 alpha-1-B glycoprotein Homo sapiens 36-58 21591266-10 2011 CONCLUSION AND CLINICAL RELEVANCE: The 13.8 kDa A1BG fragment had a high discriminatory power for steroid resistance in pediatric nephrotic syndrome, but is only present in a subset of patients. Steroids 98-105 alpha-1-B glycoprotein Homo sapiens 48-52 8822445-11 1995 Specificity of the granulosa cell response to IL-1 alpha and IL-1 beta was demonstrated by abrogation of steroid inhibition with anti-IL-1 alpha and IL-1 beta neutralizing antibodies. Steroids 105-112 interleukin 1 alpha Homo sapiens 134-144 8822445-13 1995 IL-1 alpha and IL-1 beta also exerted indirect effects on steroid production via white blood cells that are usually present in granulosa cell cultures if steps are not taken to remove them. Steroids 58-65 interleukin 1 alpha Homo sapiens 0-10 8530593-6 1995 Regulation of IGFBP-1 phosphorylation by sex steroids was studied by comparing women receiving a combined oral contraceptive with women on no medication. Steroids 45-53 insulin like growth factor binding protein 1 Homo sapiens 14-21 21396695-0 2011 The expression of vascular endothelial growth factor and its receptors (flt1/fms, flk1/KDR, flt4) and vascular endothelial growth inhibitor in the bovine uterus during the sexual cycle and their correlation with serum sex steroids. Steroids 222-230 vascular endothelial growth factor A Bos taurus 18-52 21396695-1 2011 The present study was conducted to demonstrate of the immunohistochemical localization of vascular endothelial growth factor (VEGF) and its receptors (flt1/fms, flk1/KDR and flt4) as well as vascular endothelial growth inhibitor (VEGI) and to determine the correlation of VEGF and its receptors and VEGI with serum sex steroids (estrogen and progesterone) in the bovine uterus during the sexual cycle. Steroids 319-327 vascular endothelial growth factor A Bos taurus 90-124 21396695-1 2011 The present study was conducted to demonstrate of the immunohistochemical localization of vascular endothelial growth factor (VEGF) and its receptors (flt1/fms, flk1/KDR and flt4) as well as vascular endothelial growth inhibitor (VEGI) and to determine the correlation of VEGF and its receptors and VEGI with serum sex steroids (estrogen and progesterone) in the bovine uterus during the sexual cycle. Steroids 319-327 vascular endothelial growth factor A Bos taurus 126-130 21396695-9 2011 Furthermore, this indicates that ovarian steroid hormones play a significant role in regulating the expression of VEGF and its receptors as well as VEGI. Steroids 41-57 vascular endothelial growth factor A Bos taurus 114-118 23506869-4 2013 For example, the sodium-dependent organic anion transporter (SOAT; SLC10A6) transports primarily sulfated steroids. Steroids 106-114 solute carrier family 10 member 6 Homo sapiens 17-59 23506869-4 2013 For example, the sodium-dependent organic anion transporter (SOAT; SLC10A6) transports primarily sulfated steroids. Steroids 106-114 solute carrier family 10 member 6 Homo sapiens 61-65 23506869-4 2013 For example, the sodium-dependent organic anion transporter (SOAT; SLC10A6) transports primarily sulfated steroids. Steroids 106-114 solute carrier family 10 member 6 Homo sapiens 67-74 23319492-8 2013 Inhibition of the IGF1R/INSR signalling axis attenuated the effects of IGF2 on steroid hormone synthesis. Steroids 79-94 insulin like growth factor 1 receptor Homo sapiens 18-23 8541229-8 1995 Further studies on the addition of conditioned medium from high density GH3 cell cultures, to low density steroid free cells, strongly suggested that the ER within these cells was responsible for the production of autocrine/paracrine survival factors. Steroids 106-113 estrogen receptor 1 Rattus norvegicus 154-156 23314986-1 2013 INTRODUCTION: Dehydroepiandrosterone sulfate (DHEA(S)) is a multi-functional steroid implicated in a broad range of biological effects, including obesity, diabetes, bone metabolism, neuroprotection, and anti-tumorigenesis. Steroids 77-84 sulfotransferase family 2A member 1 Homo sapiens 46-53 21555074-2 2011 Previous work has demonstrated robust activation of TRPM3 by the neuroactive steroid pregnenolone sulfate (PS), but its in vivo gating mechanisms and functions remained poorly understood. Steroids 77-84 transient receptor potential cation channel, subfamily M, member 3 Mus musculus 52-57 8547067-10 1995 In contrast, there may be a 50% chance of a sustained remission, off steroids, in children who are steroid-dependent and transfusion-independent at the time of IL-3 therapy, suggesting a possible role for a short course of IL-3 earlier in the treatment of children with steroid-responsive DBA. Steroids 99-106 interleukin 3 Homo sapiens 223-227 21675127-3 2011 RESULTS: Wrist splinting and local steroid injection are effective in patients with mild to moderate CTS in the short-term, however, patients with recurrent CTS have to accept surgical treatment. Steroids 35-42 transthyretin Homo sapiens 101-104 21145937-0 2011 Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport: SHP2 as a potential tyrosine phosphatase involved in steroid synthesis. Steroids 138-145 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 85-89 22684157-2 2013 The authors hypothesised: 1) an association of SIP with the use of antenatal steroids (ANS) and indometacin either as prophylaxis for intraventricular hemorrhage (IVH) (P Indo) or for treatment of PDA (Indo/PDA) and 2) an increased risk of death or abnormal neurodevelopmental outcomes in infants with SIP at 18-22 months corrected age. Steroids 77-85 transcription factor AP-2 beta Homo sapiens 202-217 8593884-2 1995 The recent finding of the presence of estrogen receptor in both osteoblasts and osteoclasts has suggested a direct role of steroid hormones on bone tissue. Steroids 123-139 estrogen receptor 1 (alpha) Mus musculus 38-55 23220124-2 2013 Our recent findings demonstrated that interactions of the alpha4 isoform with cardiotonic steroids (CTS) like ouabain induce signaling cascades that resemble the so-called non-classical testosterone pathway characterized by activation of the c-Src/c-Raf/Erk1/2/CREB signaling cascade. Steroids 90-98 cAMP responsive element binding protein 1 Homo sapiens 261-265 23213199-6 2013 In addition, it was observed that H(2)O(2) induced translocation of Bax to mitochondria; however, in the presence of the steroid this effect was abrogated suggesting that members of the Bcl-2 family may be regulated by E(2) to exert an antiapoptotic effect. Steroids 121-128 BCL2-associated X protein Mus musculus 68-71 21273900-10 2011 CONCLUSIONS: Local procaine HCl injection and steroid injection effectively reduced the symptoms of CTS and equally improved electrophysiologic findings. Steroids 46-53 transthyretin Homo sapiens 100-103 7559897-2 1995 It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) production. Steroids 42-50 insulin like growth factor binding protein 3 Homo sapiens 153-174 21220406-2 2011 In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates the transcription of target genes. Steroids 128-135 androgen receptor Mus musculus 83-100 21220406-2 2011 In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates the transcription of target genes. Steroids 128-135 androgen receptor Mus musculus 102-104 23318910-1 2013 OBJECTIVE: Hydroxyl-delta-5-steroid dehydrogenase (HSD3B1) is an enzyme that catalyzes the oxidative conversion of delta-5-3 beta-hydroxyl steroids to the delta-4-3-keto configuration and is involved in steroid hormone synthesis. Steroids 203-218 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 51-57 23160983-10 2013 CONCLUSIONS: GR-beta up-regulation by IL-17/IL-23 cytokines is associated with induced steroid insensitivity in PBMCs, observed as diminished Dexamethasone"s effects on cell proliferation, apoptosis and gene regulation. Steroids 87-94 interleukin 17A Homo sapiens 38-43 7559897-2 1995 It is generally believed that gonadal sex steroids stimulate pulsatile GH secretion, which, in turn, stimulates insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) production. Steroids 42-50 insulin like growth factor binding protein 3 Homo sapiens 176-183 7545059-10 1995 Our findings document local elevations of IL-1 beta, GM-CSF, and chemokines in the nasal secretions after allergen challenges and their inhibition by steroids. Steroids 150-158 colony stimulating factor 2 Homo sapiens 53-59 21347289-6 2011 Here we demonstrate that in low steroid conditions 1,25-dihydroxyvitamin D3 upregulates the expression of TRPV6, enhances the proliferation by increasing the number of cells entering into S-phase. Steroids 32-39 transient receptor potential cation channel subfamily V member 6 Homo sapiens 106-111 7476982-9 1995 The capacity for C21 steroid biosynthesis in primitive gut and skin during organogenesis raises the question whether local production of steroid hormones may be required for normal cellular growth and differentiation of these tissues during embryogenesis. Steroids 21-28 transducin (beta)-like 1X-linked receptor 1 Mus musculus 17-20 23275455-8 2013 For example, the induction in differentiating HESCs of DHRS3, encoding a highly conserved enzyme that catalyzes the oxidation/reduction of retinoids and steroids, was enhanced by aldosterone, attenuated in response to MR knockdown, and abolished upon treatment with the MR antagonist RU26752. Steroids 153-161 dehydrogenase/reductase 3 Homo sapiens 55-60 7796808-7 1995 Forced expression of CIS by steroid reduced the growth rate of these transformants, suggesting a negative role of CIS in signal transduction. Steroids 28-35 cytokine inducible SH2 containing protein Homo sapiens 21-24 22996440-7 2013 Using RT-PCR, we showed that the full-length Cbg mRNA is present in those regions, indicating an intrinsic expression of the steroid-binding globulin. Steroids 125-132 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 45-48 21204730-3 2011 The human sigma-1 receptor gene contains a steroid-binding component and gonadal steroid dehydroepiandrosterone (DHEA) which interacts with the sigma-1 receptor. Steroids 43-50 sigma non-opioid intracellular receptor 1 Rattus norvegicus 10-26 21204730-3 2011 The human sigma-1 receptor gene contains a steroid-binding component and gonadal steroid dehydroepiandrosterone (DHEA) which interacts with the sigma-1 receptor. Steroids 43-50 sigma non-opioid intracellular receptor 1 Rattus norvegicus 144-160 21289214-7 2011 The predominance of intraglomerular T-bet expression relative to GATA3 expression associated with poor response to treatment with bolus steroid. Steroids 136-143 GATA binding protein 3 Homo sapiens 65-70 7625750-0 1995 Connection between immunosuppressants and steroids via HSP90. Steroids 42-50 heat shock protein 90 alpha family class A member 1 Homo sapiens 55-60 24377507-2 2013 Functional analyses have demonstrated fundamental roles of KiSS-1 in whole body homeostasis including sexual differentiation of brain, action on sex steroids and metabolic regulation of fertility essential for human puberty and maintenance of adult reproduction. Steroids 149-157 KiSS-1 metastasis suppressor Homo sapiens 59-65 21264241-2 2011 p66Shc protein level is elevated in several carcinomas and steroid-treated human cancer cells. Steroids 59-66 src homology 2 domain-containing transforming protein C1 Mus musculus 0-6 7626458-0 1995 Regulation of the genes for insulin-like growth factor (IGF) I and II and their receptors by steroids and gonadotropins in the ovary. Steroids 93-101 insulin-like growth factor 1 Rattus norvegicus 28-69 21264241-3 2011 Several lines of evidence indicate that p66Shc plays a critical role in steroid-related carcinogenesis, and steroids play a role in its elevated levels in those cells without known mechanism. Steroids 72-79 src homology 2 domain-containing transforming protein C1 Mus musculus 40-46 21264241-4 2011 METHODS AND FINDINGS: In this study, we investigated the molecular mechanism by which steroid hormones up-regulate p66Shc protein level. Steroids 86-102 src homology 2 domain-containing transforming protein C1 Mus musculus 115-121 21264241-5 2011 In steroid-treated human prostate and ovarian cancer cells, p66Shc protein levels were elevated, correlating with increased cell proliferation. Steroids 3-10 src homology 2 domain-containing transforming protein C1 Mus musculus 60-66 22496329-2 2013 We studied the efficacy of the oral CRTH2 antagonist OC000459 in steroid-naive asthmatic patients. Steroids 65-72 prostaglandin D2 receptor 2 Homo sapiens 36-41 7596682-9 1995 A possible role of female sex steroids was discussed in the regulation of M-CSF production by mammary gland epithelial cells. Steroids 30-38 colony stimulating factor 1 Homo sapiens 74-79 21264241-6 2011 These steroid effects on p66Shc protein and cell growth were competed out by the respective antagonist. Steroids 6-13 src homology 2 domain-containing transforming protein C1 Mus musculus 25-31 21264241-7 2011 Further, actinomycin D and cyclohexamide could only partially block the elevated p66Shc protein level by steroids. Steroids 105-113 src homology 2 domain-containing transforming protein C1 Mus musculus 81-87 21264241-10 2011 CONCLUSIONS: The data collectively indicate that functional steroid receptors are required in steroid up-regulation of p66Shc protein levels in prostate and ovarian cancer cells, correlating with cell proliferation. Steroids 60-67 src homology 2 domain-containing transforming protein C1 Mus musculus 119-125 21264241-11 2011 In these steroid-treated cells, elevated p66Shc protein level is apparently in part due to inhibiting its ubiquitination. Steroids 9-16 src homology 2 domain-containing transforming protein C1 Mus musculus 41-47 23150613-1 2012 PURPOSE: This study sought to determine whether a Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)-specific morpholino (MO) could decrease neovascularization, thereby enhancing murine cornea transplant survival, and if this effect is synergistic with steroid therapy. Steroids 257-264 FMS-like tyrosine kinase 1 Mus musculus 50-95 7534765-10 1995 Our data suggest that PSA can no longer be regarded as a specific prostatic protein because it is produced by breast tumors with good prognosis and by normal breast tissue after steroid hormone stimulation. Steroids 178-193 kallikrein related peptidase 3 Homo sapiens 22-25 23150613-1 2012 PURPOSE: This study sought to determine whether a Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)-specific morpholino (MO) could decrease neovascularization, thereby enhancing murine cornea transplant survival, and if this effect is synergistic with steroid therapy. Steroids 257-264 FMS-like tyrosine kinase 1 Mus musculus 97-103 23136395-2 2012 The orphan nuclear receptor SF1 (NR5A1) has been shown to regulate the expression of enzymes involved in steroid production in vitro. Steroids 105-112 nuclear receptor subfamily 5, group A, member 1 Mus musculus 33-38 23388484-2 2012 The study was aimed to investigate the effect of steroid substitution on serum osteoprotegerin and receptor activator of nuclear factor kappa-beta ligand (RANKL) levels in relation to bone mineral density (BMD) in PAI. Steroids 49-56 TNF superfamily member 11 Homo sapiens 99-153 23388484-2 2012 The study was aimed to investigate the effect of steroid substitution on serum osteoprotegerin and receptor activator of nuclear factor kappa-beta ligand (RANKL) levels in relation to bone mineral density (BMD) in PAI. Steroids 49-56 TNF superfamily member 11 Homo sapiens 155-160 20969731-14 2011 Thus, steroid actions require an intrinsic but unknown function of CBG, which allows the sufficient supply of the hormone/s to the target tissue. Steroids 6-13 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 67-70 21196375-4 2011 Different populations of hypothalamic Kiss1 neurons have been described, which mediate either the positive or negative feedback of sex steroids in the sexually differentiated brain of rodents. Steroids 135-143 KiSS-1 metastasis suppressor Homo sapiens 38-43 7756451-9 1995 We tested whether the sex difference in HPG/POA responsivity to neuromodulation is related to the steroid milieu in the hosts. Steroids 98-105 gonadotropin releasing hormone 1 Mus musculus 40-43 21841252-8 2011 Our results provide evidence for a gender-associated modulation of brain Abeta levels and brain sex steroid hormones by TTR, and suggest that reduced levels of brain testosterone and 17beta-estradiol in female mice with TTR genetic reduction might underlie their increased AD-like neuropathology. Steroids 100-107 transthyretin Mus musculus 120-123 7696141-1 1995 A homology model of the rat 17 alpha-hydroxylase-17,20 desmolase (CYP17) steroid binding domain was derived from the alpha/beta F supersecondary structural element of the 3 alpha/20 beta hydroxysteroid dehydrogenase (HSD) of Streptomyces hydrogenans that constitutes a major segment of the C19 steroid binding cavity. Steroids 73-80 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 66-71 21116747-5 2010 The SMILE (steroid, methotrexate, ifosfamide, L: -asparaginase and etoposide) regimen is one of the promising regimens for advanced or relapsed/refractory ENKL, but its myelotoxicity is strong. Steroids 11-18 transmembrane O-mannosyltransferase targeting cadherins 3 Homo sapiens 4-9 22851291-0 2012 The effects of gonadal steroid manipulation on the expression of Kiss1 mRNA in rat arcuate nucleus during postnatal development. Steroids 23-30 KiSS-1 metastasis-suppressor Rattus norvegicus 65-70 22851291-3 2012 In this study, we investigated the effect of gonadal steroid manipulation on the sex difference in Kiss1 expression in ARC of rats. Steroids 53-60 KiSS-1 metastasis-suppressor Rattus norvegicus 99-104 22851291-7 2012 Altogether, our results indicate that ARC Kiss1 expression is negatively regulated by gonadal steroids from early postnatal stages, and that the sex difference in ARC Kiss1 expression is attributed to the difference in circulating gonadal steroid levels. Steroids 94-102 KiSS-1 metastasis-suppressor Rattus norvegicus 42-47 7696141-1 1995 A homology model of the rat 17 alpha-hydroxylase-17,20 desmolase (CYP17) steroid binding domain was derived from the alpha/beta F supersecondary structural element of the 3 alpha/20 beta hydroxysteroid dehydrogenase (HSD) of Streptomyces hydrogenans that constitutes a major segment of the C19 steroid binding cavity. Steroids 194-201 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 66-71 22851291-7 2012 Altogether, our results indicate that ARC Kiss1 expression is negatively regulated by gonadal steroids from early postnatal stages, and that the sex difference in ARC Kiss1 expression is attributed to the difference in circulating gonadal steroid levels. Steroids 94-101 KiSS-1 metastasis-suppressor Rattus norvegicus 42-47 7696141-2 1995 A CYP17 arginine-rich domain, including Arg346, Arg361 and Arg363, that has previously been shown to be important to CYP17 catalytic activity, is conserved in this HSD structural element between two HSD domains known to be important to C19 steroid binding. Steroids 240-247 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 2-7 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Steroids 20-27 vitamin D receptor Homo sapiens 162-180 7696141-2 1995 A CYP17 arginine-rich domain, including Arg346, Arg361 and Arg363, that has previously been shown to be important to CYP17 catalytic activity, is conserved in this HSD structural element between two HSD domains known to be important to C19 steroid binding. Steroids 240-247 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 117-122 21113195-1 2010 Vitamin D is a seco-steroid involved in calcium and phosphorus metabolism, and bone formation and mineralization, through binding to a specific nuclear receptor, vitamin D receptor (VDR). Steroids 20-27 vitamin D receptor Homo sapiens 182-185 22998747-7 2012 Finally, we show that STR5 specifically inhibits ERalpha- and AR-dependent transactivation of target genes in steroid-sensitive cancer cells, consistent with disruption of the targeted Pus1p-SRA pathway. Steroids 110-117 steroid receptor RNA activator 1 Homo sapiens 191-194 7696141-3 1995 These two HSD motifs, in addition to a C-terminal domain at the apex of the steroid binding cavity, are also present in similar though not identical forms in the rat CYP17 sequence. Steroids 76-83 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 166-171 7743645-3 1995 In the present study, we examined the effects of hormone manipulations on estrogen receptor (ER) mRNA levels in the preoptic area of neonatal male and female rats to test the hypothesis that gonadal steroid hormones regulate ER mRNA during the perinatal period. Steroids 199-215 estrogen receptor 1 Rattus norvegicus 225-227 21119734-1 2010 The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system. Steroids 103-110 translocator protein Homo sapiens 4-33 21119734-1 2010 The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial membrane of steroid-synthesizing cells, including those in the central and peripheral nervous system. Steroids 103-110 translocator protein Homo sapiens 35-39 7816067-4 1995 The production of interleukin-6 by stromal osteoblastic cells, as well as the responsiveness of bone marrow cells to cytokines such as interleukin-6 and interleukin-11, is regulated by sex steroids. Steroids 189-197 interleukin 11 Homo sapiens 153-167 20655882-4 2010 While the exact function of the PBR remains a matter of debate, it has been implicated in heme and steroid synthesis, cellular growth and differentiation, oxygen consumption and apoptosis. Steroids 99-106 translocator protein Homo sapiens 32-35 7742005-6 1995 Tumour cell expression of CSF-1R is under the control of several steroid hormones (glucocorticoids and progestins) and tumour cell CSF-1 expression appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. Steroids 65-81 colony stimulating factor 1 Homo sapiens 26-31 20537804-0 2010 Chronic anabolic androgenic steroid exposure alters corticotropin releasing factor expression and anxiety-like behaviors in the female mouse. Steroids 28-35 corticotropin releasing hormone Mus musculus 52-82 7588391-2 1995 We have demonstrated the presence of a phosphoprotein (p43) that responds to cAMP signals to induce steroid synthesis in adrenocortical tissue, an effect that is blocked by phospholipase A2 inhibitors. Steroids 100-107 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 Homo sapiens 55-58 20817868-8 2010 Furthermore, expression of both IL-27 and IFN-gamma was increased in the induced sputum of steroid-refractory asthmatics. Steroids 91-98 interleukin 27 Mus musculus 32-37 8714029-3 1995 corticotropin releasing hormone (CRH)-adrenocorticotropic hormone (ACTH)-adrenal steroids (aldosterone, corticosterone); 2. renin-angiotensin; 3. Steroids 81-89 corticotropin releasing hormone Gallus gallus 0-31 20817868-9 2010 These results suggest that a potential mechanism for steroid resistance in asthma is the activation of MyD88-dependent pathways in macrophages that are triggered by IL-27 and IFN-gamma, and that manipulation of these pathways may be a therapeutic target. Steroids 53-60 myeloid differentiation primary response gene 88 Mus musculus 103-108 20817868-9 2010 These results suggest that a potential mechanism for steroid resistance in asthma is the activation of MyD88-dependent pathways in macrophages that are triggered by IL-27 and IFN-gamma, and that manipulation of these pathways may be a therapeutic target. Steroids 53-60 interleukin 27 Mus musculus 165-170 8597499-1 1995 The preovulatory surge of LH, or positive feedback response to oestradiol, is related to the steroid"s direct stimulating action on the pituitary gland, but we have demonstrated that, in sheep, the central nervous system plays an essential role in its action: a preovulatory GnRH surge. Steroids 93-100 Progonadoliberin-1 Ovis aries 275-279 20535129-4 2010 Because aldosterone applied alone stimulates both collagen and elastin deposition in cultures of fibroblasts and in cultures of skin explants derived from dermal stretch marks, we postulate that this steroid should be used in the treatment of damaged skin that loses its volume and elasticity. Steroids 200-207 elastin Homo sapiens 63-70 7672777-1 1995 The effects of gonadal steroids on the secretion and gene expression of macrophage colony-stimulating factor (M-CSF) and on the secretion of transforming growth factor (TGF)-beta 1 and TGF-beta 2 by human endometrial stromal cells (ESCs) were examined by an in vitro system of ESC differentiation (decidualization). Steroids 23-31 colony stimulating factor 1 Homo sapiens 72-108 20349157-2 2010 Data here reported show for the first time that the mRNA levels of two isoforms of myelin basic protein (MBP), 18.5 and 21.5 kDa, are decreased in the spinal cord of streptozotocin-treated rats and that treatment with a neuroactive steroid, such as progesterone (P), may counteract this effect. Steroids 232-239 myelin basic protein Rattus norvegicus 83-103 20349157-2 2010 Data here reported show for the first time that the mRNA levels of two isoforms of myelin basic protein (MBP), 18.5 and 21.5 kDa, are decreased in the spinal cord of streptozotocin-treated rats and that treatment with a neuroactive steroid, such as progesterone (P), may counteract this effect. Steroids 232-239 myelin basic protein Rattus norvegicus 105-108 7536238-1 1995 There is a growing body of evidence indicating that prostate-specific antigen (PSA) may be present in many steroid hormone-stimulated epithelial tissues other than that of the prostate. Steroids 107-122 kallikrein related peptidase 3 Homo sapiens 52-83 21206198-8 2010 Among sex steroids analyzed, only serum DHEA-S level was significantly different among the groups (p=0.026), showing a decreasing trend with age. Steroids 10-18 sulfotransferase family 2A member 1 Homo sapiens 40-46 8587005-9 1995 These and our previous data as well as reports by other groups support the view that PSA is a ubiquitous biochemical marker of steroid hormone action. Steroids 127-142 kallikrein related peptidase 3 Homo sapiens 85-88 21206198-12 2010 Among serum sex steroids, DHEA-S was the most correlated parameter with autonomic functions. Steroids 16-24 sulfotransferase family 2A member 1 Homo sapiens 26-32 21364678-7 2010 Orai1 rescue, following Orai1 transfection of steroid-deprived cells, re-established the store-operated channel current and restored the normal rate of apoptosis. Steroids 46-53 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 7623315-2 1995 In the former category are the gonadal steroid hormones oestrogen and progesterone which alter the characteristics of GnRH secretion during the oestrous and seasonal cycles. Steroids 39-55 Progonadoliberin-1 Ovis aries 118-122 21364678-7 2010 Orai1 rescue, following Orai1 transfection of steroid-deprived cells, re-established the store-operated channel current and restored the normal rate of apoptosis. Steroids 46-53 ORAI calcium release-activated calcium modulator 1 Homo sapiens 24-29 7623315-4 1995 Therefore, some other steroid-sensitive neuronal system must relay this information to the GnRH neurones. Steroids 22-29 Progonadoliberin-1 Ovis aries 91-95 7596232-9 1995 Estradiol and progesterone in portal blood, which collects the steroids secreted by the luteoma, were significantly reduced by GnRH-a treatment in both models. Steroids 63-71 gonadotropin releasing hormone 1 Rattus norvegicus 127-133 20826654-6 2010 LXR ligand treatment of streptozotocin-treated rats increases expression in the sciatic nerve of steroidogenic acute regulatory protein (a molecule involved in the transfer of cholesterol into mitochondria), of the enzyme P450scc (responsible for conversion of cholesterol into pregnenolone), of 5alpha-reductase (an enzyme involved in the generation of neuroactive steroids) and of classical LXR targets involved in cholesterol efflux, such as ABCA1 and ABCG1. Steroids 366-374 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 222-229 7596232-11 1995 These results clearly show that the GnRH-a is effective in inhibiting tumor growth or reducing its volume, when already developed; furthermore, it suppresses tumor steroid hormone production. Steroids 164-179 gonadotropin releasing hormone 1 Rattus norvegicus 36-40 20593167-0 2010 Effects of p-glycoprotein on steroid-induced osteonecrosis of the femoral head. Steroids 29-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 11-25 7888490-0 1994 Regulation of connexin26 and connexin43 expression in rat endometrium by ovarian steroid hormones. Steroids 81-97 gap junction protein, beta 2 Rattus norvegicus 14-24 20593167-1 2010 P-glycoprotein (P-gp) activity may play an important role in steroid-induced osteonecrosis of the femoral head (ONF); however, the precise mechanism of its pathogenesis remains unknown. Steroids 61-68 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-14 20593167-1 2010 P-glycoprotein (P-gp) activity may play an important role in steroid-induced osteonecrosis of the femoral head (ONF); however, the precise mechanism of its pathogenesis remains unknown. Steroids 61-68 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 16-20 7988451-1 1994 LHRH synthesis and release are modulated in vivo by gonadal steroids. Steroids 60-68 gonadotropin releasing hormone 1 Mus musculus 0-4 20593167-2 2010 Therefore, we investigated the effects of increased P-gp activity on steroid-induced ONF using a rat model. Steroids 69-76 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 52-56 20593167-8 2010 Taken together, our findings suggested that enhanced P-gp activity was able to decrease the risk of steroid-induced ONF, possibly by inhibiting adipogenesis and apoptosis in the femoral head. Steroids 100-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 53-57 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Steroids 176-191 vitamin D receptor Homo sapiens 282-300 20667908-3 2010 In addition, over the past decade there has been a dramatic increase in our understanding of the many biological actions that result from vitamin D acting through its daughter steroid hormone, 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] in collaboration with its cognate vitamin D receptor (VDR). Steroids 176-191 vitamin D receptor Homo sapiens 302-305 7988451-2 1994 Although immunocytochemical and autoradiographic studies failed to detect appreciable amounts of estrogen or androgen receptor in LHRH-producing neurons, the recent finding that the promoter region of the LHRH gene contains several steroid hormone-responsive elements indicates a possible direct effect of sex steroids on these specialized neurons. Steroids 232-247 gonadotropin releasing hormone 1 Mus musculus 205-209 7988451-2 1994 Although immunocytochemical and autoradiographic studies failed to detect appreciable amounts of estrogen or androgen receptor in LHRH-producing neurons, the recent finding that the promoter region of the LHRH gene contains several steroid hormone-responsive elements indicates a possible direct effect of sex steroids on these specialized neurons. Steroids 310-318 gonadotropin releasing hormone 1 Mus musculus 205-209 21122315-8 2010 The levels of anti-GPIIb/IIIa or anti-GPIb/IX or both of them dropped or disappeared in patients being responsive to steroid therapy. Steroids 117-124 integrin subunit alpha 2b Homo sapiens 19-24 7988451-10 1994 In conclusion, GT1-1 cells possess several elements of the machinery through which sex steroids may influence LHRH dynamics. Steroids 87-95 gonadotropin releasing hormone 1 Mus musculus 110-114 7541482-8 1994 Furthermore, anti-inflammatory agents such as steroids and anti-allergic drugs were found to suppress the release of GM-CSF from airway epithelial cells in vitro. Steroids 46-54 colony stimulating factor 2 Homo sapiens 117-123 20726776-6 2010 An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2). Steroids 114-121 SRY-box transcription factor 2 Homo sapiens 67-71 7529973-5 1994 We found severe toxicity by this steroid at high concentration (10(-6) M: 35% decrease in CD62L+ T cells, 22% drop specifically in CD4+CD62L+ cells), suggesting the onset of receptor-mediated apoptotic events. Steroids 33-40 selectin L Homo sapiens 90-95 7529973-5 1994 We found severe toxicity by this steroid at high concentration (10(-6) M: 35% decrease in CD62L+ T cells, 22% drop specifically in CD4+CD62L+ cells), suggesting the onset of receptor-mediated apoptotic events. Steroids 33-40 selectin L Homo sapiens 135-140 20698801-9 2010 After 3 courses of steroid pulse therapy, anti-AQP4 antibodies were positive. Steroids 19-26 aquaporin 4 Homo sapiens 47-51 7529973-8 1994 Thus, steroids seem to modulate CD4+CD62L+ cell homing by means of receptor-mediated mechanisms. Steroids 6-14 selectin L Homo sapiens 36-41 7977723-1 1994 In the present study, we have characterized the beta 2-adrenergic receptor (beta 2-AR)-adenosine 3",5"-cyclic monophosphate (cAMP) system of the rat thymus gland and examined the hormonal regulation of the thymic beta 2-AR gene expression under physiological or pharmacological conditions accompanied by marked alterations of the sex steroid hormone milieu. Steroids 334-349 adrenoceptor beta 2 Rattus norvegicus 48-74 20726797-6 2010 An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2). Steroids 114-121 SRY-box transcription factor 2 Homo sapiens 67-71 22882449-1 2012 BACKGROUND: IL-17A is associated with different asthma phenotypes as virus-associated or steroid-resistant asthma. Steroids 89-96 interleukin 17A Mus musculus 12-18 7977723-1 1994 In the present study, we have characterized the beta 2-adrenergic receptor (beta 2-AR)-adenosine 3",5"-cyclic monophosphate (cAMP) system of the rat thymus gland and examined the hormonal regulation of the thymic beta 2-AR gene expression under physiological or pharmacological conditions accompanied by marked alterations of the sex steroid hormone milieu. Steroids 334-349 adrenoceptor beta 2 Rattus norvegicus 76-85 7977723-7 1994 The modulation of the thymic beta 2-AR-cAMP signaling system by the preexisting sex steroid milieu, coupled with the sex-dependent adrenergic modulation of thymic cell-mediated immune response, may contribute to the various sex-related alterations in immune responsiveness and could play a role in sexually related immune disorders. Steroids 84-91 adrenoceptor beta 2 Rattus norvegicus 29-38 20600902-7 2010 The percentage of the CX3CR1 positive staining area was a predictor for steroid responsiveness and for worse clinical outcome 3 and 12 months after transplantation. Steroids 72-79 C-X3-C motif chemokine receptor 1 Homo sapiens 22-28 7951266-1 1994 The Drosophila melanogaster E74A gene is expressed in response to the steroid hormone ecdysone. Steroids 70-85 Ecdysone-induced protein 74EF Drosophila melanogaster 28-32 20689830-9 2010 Overall, these studies suggest that the onset of pubertal kisspeptin expression is not dependent on reproductive hormones, but that gonadal sex steroids critically shape the hypothalamic kisspeptin neuronal subpopulations to make distinct contributions to the activation and control of the reproductive hormone cascade at the time of puberty. Steroids 144-152 KiSS-1 metastasis-suppressor Mus musculus 187-197 20463057-2 2010 In steroidogenic tissues, SR-BI supplies cholesterol for steroid hormone production. Steroids 57-72 scavenger receptor class B member 1 Homo sapiens 26-31 22622803-7 2012 These data show that expression of KDR and its co-receptor NRP-1 are up-regulated by short photoperiod and that this effect is not dependent on ovarian steroids. Steroids 152-160 kinase insert domain receptor Homo sapiens 35-38 22893725-3 2012 We found that levels of Kiss1 mRNA in the arcuate nucleus (ARC) are increased prior to the age of puberty in GnRH/sex steroid-deficient hpg mice, yet levels of Kiss1 mRNA in wild-type mice remained constant, suggesting that sex steroids exert a negative feedback effect on Kiss1 expression early in development and across puberty. Steroids 118-125 KiSS-1 metastasis-suppressor Mus musculus 24-29 22893725-3 2012 We found that levels of Kiss1 mRNA in the arcuate nucleus (ARC) are increased prior to the age of puberty in GnRH/sex steroid-deficient hpg mice, yet levels of Kiss1 mRNA in wild-type mice remained constant, suggesting that sex steroids exert a negative feedback effect on Kiss1 expression early in development and across puberty. Steroids 228-236 KiSS-1 metastasis-suppressor Mus musculus 24-29 20463057-10 2010 In summary, this is the first report showing that glucocorticoid suppress SR-BI expression suggesting that steroidogenic tissues maintain steroid hormone homeostasis by prohibiting SR-BI-mediated high-density lipoprotein cholesterol uptake when the endogenous levels of glucocorticoid are elevated. Steroids 138-153 scavenger receptor class B member 1 Homo sapiens 74-79 7929803-4 1994 There is an apparent differential sensitivity of BALB/c and C57Bl/6 spleen cells to in vitro incubation with the synthetic glucocorticoid dexamethasone; IL-2 production by BALB/c spleen cells is more sensitive to the effects of steroid. Steroids 228-235 interleukin 2 Mus musculus 153-157 20421306-5 2010 Conversely, overexpression of GX secretory phospholipase A(2) (sPLA(2)), but not a catalytically inactive mutant form of GX sPLA(2), significantly reduced steroid production 30-40% in Y1 mouse adrenal cell line. Steroids 155-162 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 63-70 20627082-0 2010 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Steroids 4-19 Myc Drosophila melanogaster 68-72 7965406-2 1994 Preliminary results have already suggested a possible influence of steroids on FMS (M-CSF receptor) expression. Steroids 67-75 colony stimulating factor 1 Homo sapiens 84-89 20627082-7 2010 In conclusion, the present work reveals an unexpected function of dMyc in the systemic control of growth in response to steroid hormone signaling. Steroids 120-135 Myc Drosophila melanogaster 66-70 22914440-4 2012 The steroid derivative PBRM [3-(2-bromoethyl)-16beta-(m-carbamoylbenzyl)-17beta-hydroxy-1,3,5(10)-estratriene] emerged as a potent inhibitor of 17beta-HSD1 with an IC(50) value of 68 nmol/L for the transformation of E1 into E2. Steroids 4-11 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 144-155 22976442-7 2012 Steroids in GLUT1DS are unusual and unreported. Steroids 0-8 solute carrier family 2 member 1 Homo sapiens 12-19 7819126-10 1994 These results demonstrate a close association between DBI and mitochondrial benzodiazepine receptors and lend support to the theory that they have a possible role in the regulation of steroid production. Steroids 184-191 diazepam binding inhibitor Rattus norvegicus 54-57 22976442-8 2012 Here a remarkable immediate and effective seizure control and a dose-independent unsuccessful steroid withdrawal indicated a potential GLUT1 sensitivity to steroids. Steroids 94-101 solute carrier family 2 member 1 Homo sapiens 135-140 22976442-8 2012 Here a remarkable immediate and effective seizure control and a dose-independent unsuccessful steroid withdrawal indicated a potential GLUT1 sensitivity to steroids. Steroids 156-164 solute carrier family 2 member 1 Homo sapiens 135-140 22976442-9 2012 We review the literature on GLUT1/steroid interactions and propose that unusual steroid sensitivity in intractable childhood epilepsy might be indicative for GLUT1DS. Steroids 34-41 solute carrier family 2 member 1 Homo sapiens 158-165 22976442-9 2012 We review the literature on GLUT1/steroid interactions and propose that unusual steroid sensitivity in intractable childhood epilepsy might be indicative for GLUT1DS. Steroids 80-87 solute carrier family 2 member 1 Homo sapiens 28-33 22976442-9 2012 We review the literature on GLUT1/steroid interactions and propose that unusual steroid sensitivity in intractable childhood epilepsy might be indicative for GLUT1DS. Steroids 80-87 solute carrier family 2 member 1 Homo sapiens 158-165 20147730-0 2010 Developmental programming: effect of prenatal steroid excess on intraovarian components of insulin signaling pathway and related proteins in sheep. Steroids 46-53 LOC105613195 Ovis aries 91-98 7994320-1 1994 An original method for the culture of granulosa and thecal cells of the domestic hen was developed and used to investigate the effects of serum, of EGF and of IGFI on the multiplication of these cell types and on their secretion of steroid hormones. Steroids 232-248 IGF-I Gallus gallus 159-163 20147736-3 2010 To drive tissue-specific expression of rhIL1RN, a 1.35-kb fragment of the chicken ovalbumin promoter, which contains both the steroid-dependent regulatory element and the negative regulatory element, was used. Steroids 126-133 ovalbumin (SERPINB14) Gallus gallus 82-91 22673022-2 2012 Cholesterol side-chain cleavage enzyme (CYP11A1) and 3beta-hydroxysteroid dehydrogenase (HSD3B1) are two key enzymes in the pathway of steroid biosynthesis. Steroids 66-73 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 89-95 7531199-2 1994 The purpose of this study was to establish a suitable in vitro system to investigate the regulation of CFTR by steroid hormones. Steroids 111-127 CF transmembrane conductance regulator Rattus norvegicus 103-107 20363879-4 2010 Here, we have studied the response of corticoadrenal steroids to the peripheral administration of GLP-1 (7-36)-amide and related peptides [exendin (Ex)-3, Ex-4, and Ex-4(3-39)] in rats, mice, and humans. Steroids 53-61 glucagon Rattus norvegicus 98-103 20478621-5 2010 The results demonstrated that the expression of IGFBP1, Prolactin (PRL), HOXA10, IL11, and IL15 are co-regulated during steroid hormone-mediated decidualization of human endometrial stromal cells in vitro. Steroids 120-135 interleukin 15 Homo sapiens 91-95 7531199-10 1994 The expression of CFTR was dependent on the presence of estrogen in the culture medium, since almost undetectable levels of CFTR mRNA were observed when the cells were cultured in medium containing serum depleted of steroid hormones. Steroids 216-232 CF transmembrane conductance regulator Rattus norvegicus 18-22 7531199-12 1994 The newly developed UIT 1.16 cell line provides a valuable model to analyze the regulation of CFTR expression by steroid hormones. Steroids 113-129 CF transmembrane conductance regulator Rattus norvegicus 94-98 20138062-0 2010 Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior. Steroids 29-36 brain-derived neurotrophic factor Rattus norvegicus 136-140 7982063-6 1994 These results show that T can modulate levels of NKA-li selectively in sites previously implicated in the control of LH release and since NKA can inhibit LH and hypothalamic LH-releasing hormone (LHRH) release, these observations are in accord with our view that afferents to LHRH neurons are the targets of gonadal steroid feedback on pituitary LH release. Steroids 316-323 Natural killer alloreactivity QTL 1 Rattus norvegicus 49-52 19701599-10 2010 The results indicate that in women deficient in sex steroids, the OPG/RANKL system may play an important counter regulatory role in order to avoid bone loss and maintain BMD. Steroids 52-60 TNF superfamily member 11 Homo sapiens 70-75 7982063-6 1994 These results show that T can modulate levels of NKA-li selectively in sites previously implicated in the control of LH release and since NKA can inhibit LH and hypothalamic LH-releasing hormone (LHRH) release, these observations are in accord with our view that afferents to LHRH neurons are the targets of gonadal steroid feedback on pituitary LH release. Steroids 316-323 Natural killer alloreactivity QTL 1 Rattus norvegicus 138-141 7826314-4 1994 The secondary structure predicted for the mouse ABP alpha subunit is a very good fit with the secondary structure determined by X-ray crystallography for rabbit uteroglobin, a protein that shares with mouse ABP the capability of binding steroid. Steroids 237-244 secretoglobin, family 1B, member 29 Mus musculus 48-51 20487517-10 2010 In addition, the gene encoding the ss-chain of the luteinizing hormone (LHB) which induces steroid synthesis in the Leydig cells of the testis at onset of puberty maps to this area on SSC6. Steroids 91-98 lutropin subunit beta Sus scrofa 72-75 7826314-4 1994 The secondary structure predicted for the mouse ABP alpha subunit is a very good fit with the secondary structure determined by X-ray crystallography for rabbit uteroglobin, a protein that shares with mouse ABP the capability of binding steroid. Steroids 237-244 secretoglobin, family 1B, member 29 Mus musculus 207-210 8050575-2 1994 Binding is increased about 10-fold by previous reduction of uteroglobin with 10 mM dithiothreitol and it is not affected by previous saturation of the progesterone binding site, suggesting different binding sites for the steroid and the retinoids. Steroids 221-228 secretoglobin family 1A member 1 Homo sapiens 60-71 20178799-0 2010 Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes. Steroids 42-57 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 13-17 20178799-0 2010 Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes. Steroids 42-49 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 13-17 20178799-1 2010 The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate. Steroids 135-150 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 4-45 20178799-1 2010 The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate. Steroids 135-150 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 47-51 20178799-1 2010 The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate. Steroids 135-150 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 52-57 20178799-9 2010 These results indicate that Mrp1-/- mice have lowered steroid hormones levels, and suggests that upregulation of steroid biosynthetic enzymes may be an attempt to maintain proper steroid hormone homeostasis. Steroids 54-70 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 28-32 20178799-9 2010 These results indicate that Mrp1-/- mice have lowered steroid hormones levels, and suggests that upregulation of steroid biosynthetic enzymes may be an attempt to maintain proper steroid hormone homeostasis. Steroids 54-61 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 28-32 20178799-9 2010 These results indicate that Mrp1-/- mice have lowered steroid hormones levels, and suggests that upregulation of steroid biosynthetic enzymes may be an attempt to maintain proper steroid hormone homeostasis. Steroids 54-69 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 28-32 7519195-5 1994 The results demonstrate for the first time that human fallopian tube expresses GM-CSF and its alpha and beta receptors mRNA and contains the immunoreactive gene product for GM-CSF, and may be potentially regulated by ovarian steroids. Steroids 225-233 colony stimulating factor 2 Homo sapiens 79-85 20376328-11 2010 Up to three SNPs in SFRS3 had p-values <0.05 when comparing controls to POAG or steroid responders, but this statistical significance was lost when the p values were adjusted for multiple measures. Steroids 83-90 serine and arginine rich splicing factor 3 Homo sapiens 20-25 7519195-5 1994 The results demonstrate for the first time that human fallopian tube expresses GM-CSF and its alpha and beta receptors mRNA and contains the immunoreactive gene product for GM-CSF, and may be potentially regulated by ovarian steroids. Steroids 225-233 colony stimulating factor 2 Homo sapiens 173-179 19906185-2 2010 Compelling evidence has now documented that expression and function of hypothalamic Kiss1 system is sensitive not only to the activational effects but also to the organizing actions of sex steroids during critical stages of development. Steroids 189-197 KiSS-1 metastasis-suppressor Rattus norvegicus 84-89 7966031-1 1994 The effects of transforming growth factor alpha (TGF-alpha) on ovarian steroid secretion were investigated. Steroids 71-78 protransforming growth factor alpha Ovis aries 49-58 19906185-9 2010 As a whole, these data document the sensitivity of Kiss1 system to changes in sex steroid milieu during critical periods of sexual maturation, and strongly suggest that alterations of endogenous kisspeptin tone induced by inappropriate (early) exposures to environmental compounds with sex steroid activity might be mechanistically relevant for disruption of puberty onset and gonadotropin secretion later in life. Steroids 82-89 KiSS-1 metastasis-suppressor Rattus norvegicus 51-56 19906185-9 2010 As a whole, these data document the sensitivity of Kiss1 system to changes in sex steroid milieu during critical periods of sexual maturation, and strongly suggest that alterations of endogenous kisspeptin tone induced by inappropriate (early) exposures to environmental compounds with sex steroid activity might be mechanistically relevant for disruption of puberty onset and gonadotropin secretion later in life. Steroids 290-297 KiSS-1 metastasis-suppressor Rattus norvegicus 51-56 7953720-1 1994 Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Steroids 147-154 gonadotropin releasing hormone 1 Rattus norvegicus 0-30 20172962-1 2010 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation and is secreted by the adrenals in an age-dependent fashion, with maximum levels during the third decade and very low levels in old age. Steroids 60-67 sulfotransferase family 2A member 1 Homo sapiens 32-37 7953720-1 1994 Gonadotropin-releasing hormone (GnRH) is a major neural signal for hypothalamic control of gonadotropin secretion which in turn influences gonadal steroid synthesis. Steroids 147-154 gonadotropin releasing hormone 1 Rattus norvegicus 32-36 8034662-2 1994 Within 30 min of glucocorticoid treatment, the cellular level of C/EBP delta rises dramatically, increasing > 100-fold within 6 h. Concurrently, the level of C/EBP alpha decreases, reaching a minimum within 4 h. The dexamethasone concentration dependence and steroid specificity of these responses suggest that both processes are mediated by the glucocorticoid receptor. Steroids 262-269 CCAAT/enhancer binding protein alpha Rattus norvegicus 161-172 20142488-6 2010 The variant BDNF Val66Met should therefore be considered as a strong candidate for mediating genetic differences in ovarian steroid-related behavioral changes and disorders. Steroids 124-131 brain derived neurotrophic factor Homo sapiens 12-16 8086337-3 1994 The experiments presented here were designed to examined the effects of neonatal estrogen exposure on the expression of two genes, lactoferrin and epidermal growth factor, that are subject to steroid hormone regulation. Steroids 192-207 lactotransferrin Mus musculus 131-142 8086337-3 1994 The experiments presented here were designed to examined the effects of neonatal estrogen exposure on the expression of two genes, lactoferrin and epidermal growth factor, that are subject to steroid hormone regulation. Steroids 192-207 epidermal growth factor Mus musculus 147-170 20111892-3 2010 p66Shc protein level correlates with the proliferation of several carcinoma cells and can be regulated by steroid hormones. Steroids 106-113 src homology 2 domain-containing transforming protein C1 Mus musculus 0-6 20111892-4 2010 Recent advances point that p66Shc protein plays a role in mediating cross-talk between steroid hormones and redox signals by serving as a common convergence point in signaling pathways on cell proliferation and apoptosis. Steroids 87-103 src homology 2 domain-containing transforming protein C1 Mus musculus 27-33 8194477-8 1994 We conclude that GnRH and/or the gonadotropins can modify the expression of murine lupus independently of their regulation of gonadal steroid secretion. Steroids 134-141 gonadotropin releasing hormone 1 Mus musculus 17-21 20064537-1 2010 The naturally occurring steroid dehydroepiandrosterone (DHEA) is reported to reduce glial fibrillary acidic protein (GFAP) overexpression in a model of reactive gliosis due to its conversion to estradiol by the enzyme aromatase. Steroids 24-31 glial fibrillary acidic protein Homo sapiens 84-115 20064537-1 2010 The naturally occurring steroid dehydroepiandrosterone (DHEA) is reported to reduce glial fibrillary acidic protein (GFAP) overexpression in a model of reactive gliosis due to its conversion to estradiol by the enzyme aromatase. Steroids 24-31 glial fibrillary acidic protein Homo sapiens 117-121 19733404-0 2010 Marked MMP-2 transcriptional up-regulation in mononuclear leukocytes invading the subarachnoidal space in aseptic suppurative steroid-responsive meningitis-arteritis in dogs. Steroids 126-133 matrix metallopeptidase 2 Canis lupus familiaris 7-12 7932447-11 1994 Steroids and low concentrations of cyclooxygenase inhibitors in general suppressed cytokine induced GM-CSF production. Steroids 0-8 colony stimulating factor 2 Homo sapiens 100-106 8173754-3 1994 To test this, we have studied the effect of an orally active PAF antagonist, WEB 2086, on the inhaled steroid requirements of symptomatic atopic asthmatics in a double-blind randomized placebo-controlled parallel group study. Steroids 102-109 PCNA clamp associated factor Homo sapiens 61-64 19758343-0 2010 Serum levels of IL-18 and sIL-2R in patients with alopecia areata receiving combined therapy with oral cyclosporine and steroids. Steroids 120-128 interleukin 18 Homo sapiens 16-21 19660519-3 2010 The steroid rapidly and transiently decreased total and phosphorylated NMDA receptor GluN2B subunit levels and phosphorylated extracellular signal-regulated kinase 1 in rat hippocampal synaptoneurosomes. Steroids 4-11 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 85-91 9397949-7 1994 Our data suggest that the c-myc oncogene in human endometrial carcinoma RL95-2 cells is the sensitive target gene for steroid hormone and growth factor action. Steroids 118-133 MYC proto-oncogene, bHLH transcription factor Homo sapiens 26-31 11607466-8 1994 The results also are consistent with placement of the HMGR activities encoded by hmg1 and hmg2 within discrete steroid and sesquiterpenoid biosynthetic channels. Steroids 111-118 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 Solanum tuberosum 81-85 19955756-5 2010 These functions, together with the proven roles of kisspeptins in the control of GnRH neurons and the transmission ofthe regulatory actions of key signals, such as sex steroids, metabolic hormones and environmental cues, point out that the Kiss1 system is an indispensable player of the reproductive brain, whose discovery is now considered as (one of) the most important findings in reproductive physiology in the last decades. Steroids 168-176 KiSS-1 metastasis suppressor Homo sapiens 240-245 20459597-7 2010 The second group of genes (including Fkbp5 and S3-12), which are controlled, in part, by the release of steroid hormones, was strongly activated by ethanol and opioids. Steroids 104-120 FK506 binding protein 5 Mus musculus 37-42 22577852-8 2012 The finding that ArKO mice of both sexes have a competent LH surge system suggests that oestradiol has predominantly defeminising actions on the GnRH/LH surge system in males and that the steroid-induced LH surge can occur in females even with a greatly reduced population of kisspeptin neurones in the RP3V. Steroids 188-195 KiSS-1 metastasis-suppressor Mus musculus 276-286 8119143-5 1994 We found that 1,25-(OH)2D3 promotes the plasma membrane appearance of alpha v beta 3 on avian bone marrow-derived osteoclast precursors and does so at physiological concentrations (10(-11) M) of the steroid. Steroids 199-206 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 70-84 22709513-7 2012 A specific, saturable, and single progesterone binding site with a steroid specificity characteristic of mPRs was demonstrated by saturation and competitive binding assays using T lymphocyte membranes, and PAQR7 receptors were localized on the plasma membranes by immunofluorescence. Steroids 67-74 progestin and adipoQ receptor family member 7 Bos taurus 206-211 19757177-4 2010 BRE also regulates the ubiquitination of the DNA repair complex BRCC, and the synthesis of steroid hormones. Steroids 91-107 BRISC and BRCA1 A complex member 2 Homo sapiens 0-3 8106362-3 1994 Although the total amount of PKC alpha, PKC beta, and PKC zeta are unaffected by 1,25-(OH)2-D3, this steroid hormone induces subcellular redistribution of both PKC alpha and PKC beta. Steroids 101-116 protein kinase C beta Bos taurus 174-182 19755404-8 2009 In addition to the plasma membrane, mitochondria, and smooth endoplasmic reticulum, SYP immunoreactivity was detected in the Golgi area, which is known to be involved in the regulation of mitochondrial cholesterol and the transport of steroid intermediates. Steroids 235-242 synaptophysin Homo sapiens 84-87 22726874-1 2012 Steroid-resistant asthma (SRA) refers to patients with symptoms consistent with asthma who show very poor or no response at all to high doses of inhaled or even of systemic corticosteroids. Steroids 0-7 steroid receptor RNA activator 1 Homo sapiens 26-29 7507841-5 1994 Uterine EGF-R mRNA transcript profiles showed some differences between pregnant and ovariectomized mice regardless of steroid hormone treatments. Steroids 118-133 epidermal growth factor receptor Mus musculus 8-13 22675173-1 2012 PURPOSE: Extranodal NK/T-cell lymphoma, nasal type (ENKL) is an Epstein-Barr virus (EBV)-associated lymphoma for which a new chemotherapeutic regimen called SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) recently showed promising results. Steroids 164-171 transmembrane O-mannosyltransferase targeting cadherins 3 Homo sapiens 157-162 19756449-1 2009 Serum and glucocorticoid regulated kinase 1 (Sgk1) is a serine-threonine kinase that is activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and post-translational levels. Steroids 108-116 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-43 19756449-1 2009 Serum and glucocorticoid regulated kinase 1 (Sgk1) is a serine-threonine kinase that is activated by serum, steroids, insulin, vasopressin, and interleukin 2 at the transcriptional and post-translational levels. Steroids 108-116 serum/glucocorticoid regulated kinase 1 Homo sapiens 45-49 19756449-2 2009 Sgk1 is also important in transduction of growth factors and steroid-dependent survival signals and may have a role in the development of resistance to cancer chemotherapy. Steroids 61-68 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-4 8106754-11 1994 Fibronectin, which was increased by the steroid:vehicle treatment, was reduced to more normal levels by steroid:tretinoin. Steroids 40-47 fibronectin 1 Mus musculus 0-11 19594690-3 2009 However, it has been reported that levels of the steroid dehydroepiandrosterone sulphate (DHEAS) are reduced in plasma of patients with PBC, and substitutive therapy has been suggested to improve fatigue symptoms experienced during the course of this disease. Steroids 49-56 sulfotransferase family 2A member 1 Homo sapiens 90-95 22544608-1 2012 The present study investigated the effect of surgical (SC) and immunological castration on the steroid metabolizing enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and sulfotransferase 2A1 (SULT2A1) in male pigs. Steroids 95-102 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 124-158 22544608-1 2012 The present study investigated the effect of surgical (SC) and immunological castration on the steroid metabolizing enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and sulfotransferase 2A1 (SULT2A1) in male pigs. Steroids 95-102 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 160-169 22544608-8 2012 Moreover, there was a strong correlation between mRNA and protein expression of 3beta-HSD and steroid levels. Steroids 94-101 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 80-89 22544608-10 2012 It is concluded that steroid levels can increase expression of the steroid metabolizing enzyme 3beta-HSD and thereby influence steroid metabolism, e.g. of androstenone. Steroids 21-28 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 95-104 22544608-10 2012 It is concluded that steroid levels can increase expression of the steroid metabolizing enzyme 3beta-HSD and thereby influence steroid metabolism, e.g. of androstenone. Steroids 67-74 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 95-104 19900346-2 2009 This combined with its ability to act on specific target tissues via vitamin D receptors (VDR) make its classification as a steroid hormone more appropriate. Steroids 124-139 vitamin D receptor Homo sapiens 69-88 19900346-2 2009 This combined with its ability to act on specific target tissues via vitamin D receptors (VDR) make its classification as a steroid hormone more appropriate. Steroids 124-139 vitamin D receptor Homo sapiens 90-93 8106754-11 1994 Fibronectin, which was increased by the steroid:vehicle treatment, was reduced to more normal levels by steroid:tretinoin. Steroids 104-111 fibronectin 1 Mus musculus 0-11 7507320-3 1994 We show here that MCF7 cell proliferation in steroid-stripped, serum containing media is significantly attenuated by rhIGF-BP3 (p < 0.05), with a maximal 40% inhibition of serum stimulated growth achieved by 6.25nM IGF-BP3. Steroids 45-52 insulin like growth factor binding protein 3 Homo sapiens 119-126 19758607-7 2009 It may be hypothesized that sexual steroids could exert beneficial effects through a modulation of the immune state with a lowering of the pro-inflammatory lymphocyte responses of the Th1 type and an enhancement of anti-inflammatory responses of the Th2 type. Steroids 35-43 negative elongation factor complex member C/D Homo sapiens 184-187 22544608-10 2012 It is concluded that steroid levels can increase expression of the steroid metabolizing enzyme 3beta-HSD and thereby influence steroid metabolism, e.g. of androstenone. Steroids 67-74 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 95-104 7507320-5 1994 These results demonstrate antagonism of steroid stimulated proliferation by an IGF binding protein and are compatible with the hypothesis that antiestrogen-induced accumulation of IGF-BP3 in the conditioned media of MCF7 cells contributes to the cytostatic action of these drugs. Steroids 40-47 insulin like growth factor binding protein 3 Homo sapiens 180-187 8020171-0 1994 IGF-I and EGF influence on steroid secretion and morphology of human granulosa cells of IVF-cycles and natural cycles in vitro. Steroids 27-34 epidermal growth factor Homo sapiens 10-13 22564489-0 2012 C-type Natriuretic Peptide: a novel biomarker of steroid induced bone toxicity in children with acute lymphoblastic leukemia (ALL). Steroids 49-56 natriuretic peptide C Homo sapiens 0-26 21436979-3 2009 Tacrolimus, a calcineurin inhibitor, not only complements existing treatment options but also overcomes some of the drawbacks of topical steroid therapy when given topically and thus meets the long-term needs of patients in preventing disease progression. Steroids 137-144 calcineurin binding protein 1 Homo sapiens 14-35 7999416-15 1994 Other rIL-2-related toxicities forcing exclusion from the study were severe thrombocytopenia (1 case), and generalised exfoliative dermatitis requiring steroids (1 case). Steroids 152-160 interleukin 2 Rattus norvegicus 6-11 19863077-4 2009 The 18 kDa multimeric TSPO is expressed in steroid-producing cells, primarily on the outer mitochondrial membrane. Steroids 43-50 translocator protein Rattus norvegicus 22-26 22550166-7 2012 In contrast, the recruitment of the ERalpha/AIB1 transcriptional complex to the nonclassic ER target cyclin D1 and its subsequent expression remained sensitive to steroid treatment and could be inhibited by treatment with letrozole. Steroids 163-170 ANIB1 Homo sapiens 44-48 22550166-8 2012 Molecular studies revealed that this may be due in part to direct steroid regulation of c-jun-NH(2)-kinase (JNK), signaling to Jun and Fos at the cyclin D1 promoter. Steroids 66-73 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 135-138 22521737-7 2012 Thus, genistein plays a role in the regulation of MAPK activation via GPR30, and GPR30 represents a novel target regulated by steroid hormones in PDL cells. Steroids 126-142 G protein-coupled estrogen receptor 1 Homo sapiens 81-86 19661211-4 2009 UGT2B7 exhibited a higher glucuronidation rate toward the steroids with a flat backbone, androsterone and 5alpha-diol, compared with etiocholanolone and 5beta-diol, which have a bent backbone. Steroids 58-66 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 0-6 8136300-13 1994 Moreover, the increase in Gal C-positive cells observed in response to insulin alone was not further potentiated by P. Glial cells of the peripheral nervous system, namely Schwann cells, are also sensitive to steroid hormones. Steroids 209-225 galactosylceramidase Rattus norvegicus 26-31 19406144-4 2009 We also ascertained, the capacity of these steroids to bind to the androgen receptors present in the rat prostate cytosol using labeled mibolerone (MIB) for monitoring the binding to the androgen receptor. Steroids 43-51 androgen receptor Rattus norvegicus 67-84 22348610-8 2012 Interestingly, while TSPO is known to play a role in the modulation of steroid production, in turn, steroids are also known to affect TSPO expression. Steroids 71-78 translocator protein Homo sapiens 21-25 22348610-8 2012 Interestingly, while TSPO is known to play a role in the modulation of steroid production, in turn, steroids are also known to affect TSPO expression. Steroids 100-108 translocator protein Homo sapiens 21-25 8136305-2 1994 In the present study, the effects of gonadal steroids on GnRH-induced cytoplasmic calcium ([Ca2+]i) responses in gonadotrophs were analyzed in rat pituitary cells and immortalized (alpha T3-1) murine gonadotrophs. Steroids 45-53 gonadotropin releasing hormone 1 Rattus norvegicus 57-61 22348610-8 2012 Interestingly, while TSPO is known to play a role in the modulation of steroid production, in turn, steroids are also known to affect TSPO expression. Steroids 100-108 translocator protein Homo sapiens 134-138 8136305-11 1994 The results demonstrate that the stimulatory and inhibitory effects of progesterone on agonist-induced Ca2+ signaling result from changes in Ca2+ mobilization and entry, and contribute to the modulatory actions of the steroid on GnRH-induced LH secretion. Steroids 218-225 gonadotropin releasing hormone 1 Rattus norvegicus 229-233 22348610-9 2012 As with the putative endogenous TSPO ligands, the effects of steroids on TSPO functions still have to be established. Steroids 61-69 translocator protein Homo sapiens 73-77 22348610-10 2012 In any case, steroid-TSPO interactions occur in organs and tissues as diverse as the reproductive system, kidney, and brain. Steroids 13-20 translocator protein Homo sapiens 21-25 19738069-0 2009 Role of cyclic AMP response element-binding protein in insulin-like growth factor-i receptor up-regulation by sex steroids in prostate cancer cells. Steroids 114-122 cAMP responsive element binding protein 1 Homo sapiens 8-51 19738069-0 2009 Role of cyclic AMP response element-binding protein in insulin-like growth factor-i receptor up-regulation by sex steroids in prostate cancer cells. Steroids 114-122 insulin like growth factor 1 receptor Homo sapiens 55-92 8114512-0 1994 Antiinflammatory steroids inhibit granulocyte/macrophage colony-stimulating factor production by human lung tissue. Steroids 17-25 colony stimulating factor 2 Homo sapiens 34-82 19738069-4 2009 Both sex steroids phosphorylated CREB at Ser(133) in a dose-dependent manner in androgen receptor (AR)-positive LNCaP cells, whereas only estrogens phosphorylated CREB in AR-negative PC3 cells. Steroids 9-17 cAMP responsive element binding protein 1 Homo sapiens 33-37 22348610-11 2012 In general, the steroid-TSPO interactions are thought to be part of stress responses, but may also be essential for reproductive events, embryonic development, and responses to injury, including brain injury. Steroids 16-23 translocator protein Homo sapiens 24-28 22348611-1 2012 The translocator protein (TSPO) is a five transmembrane domain protein localised primarily in the outer mitochondrial membrane of steroid-synthesizing tissues, including the brain. Steroids 130-137 translocator protein Homo sapiens 4-24 22348611-1 2012 The translocator protein (TSPO) is a five transmembrane domain protein localised primarily in the outer mitochondrial membrane of steroid-synthesizing tissues, including the brain. Steroids 130-137 translocator protein Homo sapiens 26-30 22348611-3 2012 In the recent years TSPO function has received attention in several psychiatric disorders since these diseases have been associated with unbalanced steroid levels. Steroids 148-155 translocator protein Homo sapiens 20-24 22348612-6 2012 As the major role of TSPO is steroid biosynthesis, TSPO expression is particularly high in organs involved in steroidogenesis such as the adrenals, testes, ovaries, placenta, prostate, colon, kidney, and cardiovascular system. Steroids 29-36 translocator protein Homo sapiens 21-25 22348612-6 2012 As the major role of TSPO is steroid biosynthesis, TSPO expression is particularly high in organs involved in steroidogenesis such as the adrenals, testes, ovaries, placenta, prostate, colon, kidney, and cardiovascular system. Steroids 29-36 translocator protein Homo sapiens 51-55 22348614-1 2012 Translocator protein (TSPO) is a high affinity 18 kDa drug- and cholesterol-binding protein strongly expressed in steroidogenic tissues where it mediates cholesterol transport into mitochondria and steroid formation. Steroids 114-121 translocator protein Homo sapiens 0-20 22348614-1 2012 Translocator protein (TSPO) is a high affinity 18 kDa drug- and cholesterol-binding protein strongly expressed in steroidogenic tissues where it mediates cholesterol transport into mitochondria and steroid formation. Steroids 114-121 translocator protein Homo sapiens 22-26 22221196-11 2012 These results suggest the differential actions of sex steroid hormones in modulating BDNF-TrkB signalling during adolescence. Steroids 54-70 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 90-94 22406419-0 2012 LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Steroids 78-86 translocator protein Rattus norvegicus 8-12 22406419-4 2012 In this study we have evaluated whether activation of translocator protein-18kDa (TSPO) or liver X receptors (LXRs) may affect the levels of neuroactive steroids present in the CNS of diabetic and non-diabetic animals. Steroids 153-161 translocator protein Rattus norvegicus 54-80 22406419-4 2012 In this study we have evaluated whether activation of translocator protein-18kDa (TSPO) or liver X receptors (LXRs) may affect the levels of neuroactive steroids present in the CNS of diabetic and non-diabetic animals. Steroids 153-161 translocator protein Rattus norvegicus 82-86 22406419-5 2012 We observed that the treatment with either Ro5-4864 (i.e., a ligand of TSPO) or with GW3965 (i.e., a ligand of LXRs) induced an increase of neuroactive steroids in the spinal cord, the cerebellum and the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. Steroids 152-160 translocator protein Rattus norvegicus 71-75 22200895-0 2012 NGAL distinguishes steroid sensitivity in idiopathic nephrotic syndrome. Steroids 19-26 lipocalin 2 Homo sapiens 0-4 22342158-1 2012 The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC-3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Steroids 102-109 nuclear receptor coactivator 3 Mus musculus 63-67 22232524-7 2012 Likewise, PDE8A (-/-)/B(-/-) cells had higher testosterone production than cells from either PDE8A(-/-) or PDE8B(-/-) mice, suggesting that both PDE8s work in concert to regulate steroid production. Steroids 179-186 phosphodiesterase 8A Mus musculus 10-15 22232524-7 2012 Likewise, PDE8A (-/-)/B(-/-) cells had higher testosterone production than cells from either PDE8A(-/-) or PDE8B(-/-) mice, suggesting that both PDE8s work in concert to regulate steroid production. Steroids 179-186 phosphodiesterase 8A Mus musculus 10-14 22776597-1 2012 OBJECTIVE: To evaluate the correlation between blood eosinophil (EOS)level and steroid doses in patients of bullous pemphigoid (BP). Steroids 79-86 EOS Homo sapiens 65-68 22776597-4 2012 The correlation between EOS level and steroid doses was analyzed retrospectively. Steroids 38-45 EOS Homo sapiens 24-27 28045481-6 2012 The data presented confirm that Wnt4 can efficiently rescue thymic epithelial cells from steroid-induced adipose involution at the molecular level (Talaber et al. Steroids 89-96 Wnt family member 4 Homo sapiens 32-36 28045481-8 2012 Since physiological and steroid-induced thymic epithelial senescence are identical at the molecular level, it is anticipated that sustained Wnt4 presence in the thymic context can efficiently prolong FoxN1 expression, maintain thymic epithelial identity and prevent transdifferentiation towards adipocyte lineage. Steroids 24-31 Wnt family member 4 Homo sapiens 140-144 22199361-8 2012 Thus, Daxx functioned as a signal transducer linking cAMP-stimulated HIPK3 activity with JNK/c-Jun phosphorylation and SF-1-dependent Cyp11a1 transcription for steroid synthesis. Steroids 160-167 Fas death domain-associated protein Mus musculus 6-10 22139961-7 2012 In contrast, the steroid response was significantly lower in patients with anti-GPIbalpha antibodies (9/34) or with antibodies against both GPIbalpha and GPIIbIIIa (16/54). Steroids 17-24 glycoprotein Ib platelet subunit alpha Homo sapiens 80-89 22139961-7 2012 In contrast, the steroid response was significantly lower in patients with anti-GPIbalpha antibodies (9/34) or with antibodies against both GPIbalpha and GPIIbIIIa (16/54). Steroids 17-24 glycoprotein Ib platelet subunit alpha Homo sapiens 140-149 22436185-12 2012 Lower CYP450 mRNA in entire male pigs suggests suppression of CYP1A2, CYP2A and CYP2E1 by testicular steroids at the transcriptional level. Steroids 101-109 cytochrome P450 family 1 subfamily A member 2 Sus scrofa 62-68 22166978-8 2012 Collectively, these results suggest that a KISS1R-mediated mechanism, in addition to the pubertal increase in KP-54 release we previously reported, contributes to the pubertal increase in GnRH release and that there is a switch from an ovarian steroid-independent to -dependent mechanism in the response of GnRH to KP. Steroids 244-251 KISS1 receptor Macaca mulatta 43-49 21918127-9 2012 We conclude 1) that tissue or cell-specific, partitioned expression of sex steroid synthesizing enzymes limits rather than maximizes estrogen synthesis and 2) that limiting metabolism by 3betaHSD can paradoxically promote androgen synthesis when 3betaHSD expression is high by promoting delta5-steroid flux. Steroids 75-82 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 246-254 21918127-9 2012 We conclude 1) that tissue or cell-specific, partitioned expression of sex steroid synthesizing enzymes limits rather than maximizes estrogen synthesis and 2) that limiting metabolism by 3betaHSD can paradoxically promote androgen synthesis when 3betaHSD expression is high by promoting delta5-steroid flux. Steroids 294-301 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 187-195 21918127-9 2012 We conclude 1) that tissue or cell-specific, partitioned expression of sex steroid synthesizing enzymes limits rather than maximizes estrogen synthesis and 2) that limiting metabolism by 3betaHSD can paradoxically promote androgen synthesis when 3betaHSD expression is high by promoting delta5-steroid flux. Steroids 294-301 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 246-254 23951414-4 2012 The main focus of this review is to summarize and discuss recent findings from the osteoporotic fractures in men (MrOS) cohorts regarding the impact of serum sex steroids on bone health in elderly men. Steroids 162-170 MROS Homo sapiens 114-118 21431844-2 2012 It is shown that steroid hormones may upregulate the HLA-G gene expression. Steroids 17-33 major histocompatibility complex, class I, G Homo sapiens 53-58 22830335-7 2012 These identified natural MDM2 inhibitors include a plethora of diverse chemical frameworks, ranging from flavonoids, steroids, and sesquiterpenes to alkaloids. Steroids 117-125 MDM2 proto-oncogene Homo sapiens 25-29 22204481-5 2012 TSPO is a five transmembrane domain protein (18 kDa) that is expressed predominantly in steroid-synthesizing tissues. Steroids 88-95 translocator protein Homo sapiens 0-4 22204486-13 2012 TSPO is supposed to play an important role for the synthesis of neuroactive steroids. Steroids 76-84 translocator protein Homo sapiens 0-4 22204486-14 2012 TSPO ligands may promote the synthesis of neuroactive steroids via induction of cholesterol translocation to the inner mitochondrial membrane. Steroids 54-62 translocator protein Homo sapiens 0-4 22388834-7 2012 Genetic forms of INS, with mutation of the NPHS1 and NPHS2 genes encoding nephrin and podocin, are mostly steroid resistant and very rarely recur in the transplant. Steroids 106-113 NPHS1 adhesion molecule, nephrin Homo sapiens 43-48 22388834-7 2012 Genetic forms of INS, with mutation of the NPHS1 and NPHS2 genes encoding nephrin and podocin, are mostly steroid resistant and very rarely recur in the transplant. Steroids 106-113 NPHS1 adhesion molecule, nephrin Homo sapiens 74-81 22057031-0 2012 The role of the androgen receptor in anabolic androgenic steroid-induced aggressive behavior in C57BL/6J and Tfm mice. Steroids 57-64 androgen receptor Mus musculus 16-33 22024430-1 2012 The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) and 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) enzymes are important in determining the balance of the synthesis of different steroids such as progesterone (P4), glucocorticoids, androgens, and estrogens. Steroids 220-228 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 4-66 22024430-1 2012 The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) and 17alpha-hydroxylase/17,20-lyase cytochrome P450 (P450c17) enzymes are important in determining the balance of the synthesis of different steroids such as progesterone (P4), glucocorticoids, androgens, and estrogens. Steroids 220-228 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 68-77 22024430-5 2012 The mathematical model developed in this study simulates the network of reactions catalyzed by 3beta-HSD and P450c17 that characterizes steroid synthesis in human, non-human primate, ovine, and bovine species. Steroids 136-143 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 95-104 22024430-7 2012 The model helps to understand the interplay between fluxes through the Delta(4) and Delta(5) pathways in this network, and how this determines the response of steroid synthesis to the variation in 3beta-HSD activity or in the supply of the precursor substrate, pregnenolone (P5). Steroids 159-166 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 197-206 23110082-1 2012 BACKGROUND: The objective of the study was to investigate the role of genes (HSD3B1, CYP17A1, CYP19A1, HSD17B2, HSD17B1) involved in the steroid hormone biosynthesis pathway and progesterone receptor (PGR) in the etiology of gastric cancer in a population-based two-phase genetic association study. Steroids 137-152 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 77-83 21889601-0 2011 Effects of sexual steroids on the expression of foxl2 in Gobiocypris rarus. Steroids 18-26 forkhead box L2 Homo sapiens 48-53 21670977-5 2011 The conversion of prednisolone to 20beta-hydroxy prednisolone by Streptomyces roseochromogenes TS79 was different from a previous study on the microbial transformation of steroid by this organism, which usually generates a 16alpha-hydroxy steroid product. Steroids 171-178 ATPase H+ transporting accessory protein 1 Homo sapiens 223-230 21741804-8 2011 Steroid-treated stressed animals displayed significantly increased dendritic growth and spine density, with increased levels of brain-derived neurotrophic factor (BDNF) and obtunded postsynaptic density-95 (PSD-95) levels. Steroids 0-7 brain derived neurotrophic factor Homo sapiens 128-161 21741804-8 2011 Steroid-treated stressed animals displayed significantly increased dendritic growth and spine density, with increased levels of brain-derived neurotrophic factor (BDNF) and obtunded postsynaptic density-95 (PSD-95) levels. Steroids 0-7 brain derived neurotrophic factor Homo sapiens 163-167 19491202-13 2009 Interactions between BDNF, the hypothalamus-pituitary-adrenal axis and sex steroids might play a critical role in the human homeostasis and adaptation. Steroids 75-83 brain derived neurotrophic factor Homo sapiens 21-25 19619146-1 2009 INTRODUCTION: Dehydroepiandrosterone (DHEA) and its sulfate DHEAS, which are the most abundant steroids in women, decline with age. Steroids 95-103 sulfotransferase family 2A member 1 Homo sapiens 60-65 19557730-1 2009 PURPOSE: Proton pump inhibitor (PPI) may suppress adrenal cortical steroid synthesis and release, thereby leading to electrolyte disturbances. Steroids 67-74 ATPase H+/K+ transporting subunit alpha Homo sapiens 9-20 19721334-3 2009 We focus on novel roles of PGRN as a sex steroid-responsible gene in the developing and adult rodent brain. Steroids 41-48 granulin precursor Rattus norvegicus 27-31 19721334-5 2009 We have shown that PGRN is a sex steroid-responsible gene that may be involved in masculinization of the perinatal rat brain. Steroids 33-40 granulin precursor Rattus norvegicus 19-23 19423681-7 2009 These differentially expressed genes form part of a network involving lipid, sterol, and steroid homeostatic pathways regulated by the constitutive androstane (CAR), pregnane X (PXR), peroxisome proliferator-activated alpha, and other nuclear receptors in liver. Steroids 89-96 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 160-163 19552401-1 2009 Translocator protein (18 kDa, TSPO), previously known as the peripheral-type benzodiazepine receptor, is an outer mitochondrial membrane (OMM) protein necessary for cholesterol import and steroid production. Steroids 188-195 translocator protein Homo sapiens 0-20 19552401-1 2009 Translocator protein (18 kDa, TSPO), previously known as the peripheral-type benzodiazepine receptor, is an outer mitochondrial membrane (OMM) protein necessary for cholesterol import and steroid production. Steroids 188-195 translocator protein Homo sapiens 30-34 19552401-1 2009 Translocator protein (18 kDa, TSPO), previously known as the peripheral-type benzodiazepine receptor, is an outer mitochondrial membrane (OMM) protein necessary for cholesterol import and steroid production. Steroids 188-195 translocator protein Homo sapiens 61-100 19325000-6 2009 Immunohistochemical studies show that mouse OSAP localizes almost exclusively to the steroid-producing cells of the ovary, adrenal gland, and testis. Steroids 85-92 mitochondria localized glutamic acid rich protein Mus musculus 44-48 19247652-12 2009 Since not only increases but also decreases of steroid levels affect ligand binding, a considerable fraction of the sigma-1 receptor population in cultured tumour cells or tumour-bearing animals is normally occupied by endogenous steroids. Steroids 47-54 sigma non-opioid intracellular receptor 1 Rattus norvegicus 116-132 19247652-12 2009 Since not only increases but also decreases of steroid levels affect ligand binding, a considerable fraction of the sigma-1 receptor population in cultured tumour cells or tumour-bearing animals is normally occupied by endogenous steroids. Steroids 230-238 sigma non-opioid intracellular receptor 1 Rattus norvegicus 116-132 19542427-6 2009 Production of IL-1alpha, IL-10, IL-17, IFN-gamma, G-CSF, GM-CSF, TNF-alpha, and IFN-inducible protein 10 (IP-10) correlated significantly with in vitro steroid sensitivity; however, only IL-2 and TNF-alpha reduced steroid sensitivity when added exogenously. Steroids 152-159 C-X-C motif chemokine ligand 10 Homo sapiens 80-104 19542427-6 2009 Production of IL-1alpha, IL-10, IL-17, IFN-gamma, G-CSF, GM-CSF, TNF-alpha, and IFN-inducible protein 10 (IP-10) correlated significantly with in vitro steroid sensitivity; however, only IL-2 and TNF-alpha reduced steroid sensitivity when added exogenously. Steroids 152-159 C-X-C motif chemokine ligand 10 Homo sapiens 106-111 19542427-6 2009 Production of IL-1alpha, IL-10, IL-17, IFN-gamma, G-CSF, GM-CSF, TNF-alpha, and IFN-inducible protein 10 (IP-10) correlated significantly with in vitro steroid sensitivity; however, only IL-2 and TNF-alpha reduced steroid sensitivity when added exogenously. Steroids 214-221 C-X-C motif chemokine ligand 10 Homo sapiens 106-111 19542427-7 2009 Addition of IL-10 enhanced steroid suppression. Steroids 27-34 interleukin 10 Homo sapiens 12-17 19542427-9 2009 Neutralization of IL-10 reduced steroid sensitivity. Steroids 32-39 interleukin 10 Homo sapiens 18-23 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 cytochrome P450 family 4 subfamily A member 22 Homo sapiens 154-161 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 209-215 19409404-6 2009 Differentially expressed genes included the Phase I xenobiotic, fatty acid, sterol and steroid metabolism genes Cyp2b2 and CYP2B6, Cyp3a1 and CYP3A4, and Cyp4a22 and CYP4A11; Phase II conjugation enzyme genes Ugt1a1 and UGT1A1; and Phase III ABC transporter genes Abcb1 and ABCB1. Steroids 87-94 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 220-226 19438212-7 2009 At least for the steroids, this finding is at odds with known SAR and binding interactions with the relevant receptor. Steroids 17-25 sarcosine dehydrogenase Homo sapiens 62-65 19342447-2 2009 We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss, and Dhcr7 in murine osteoprogenitor cells. Steroids 94-101 lanosterol synthase Mus musculus 149-152 19383027-3 2009 METHODS: In this study, we investigated endothelial IL-10 expression in nasal mucosa of healthy- and house dust mite allergic patients, both before and after provocation, and under nasal steroid therapy. Steroids 187-194 interleukin 10 Homo sapiens 52-57 19106226-9 2009 Altogether, our data document the sensitivity of the hypothalamic KiSS-1 system to alterations in sex steroid milieu during critical periods of brain sex differentiation, and suggest that lowering of endogenous kisspeptin tone induced by early exposures to xeno-estrogens might be mechanistically relevant for disruption of gonadotropin secretion and puberty onset later in life. Steroids 102-109 KiSS-1 metastasis-suppressor Rattus norvegicus 66-72 19224431-12 2009 Our data demonstrate that AR and ENaC are regulated by sex steroids. Steroids 59-67 androgen receptor Rattus norvegicus 26-28 19470251-0 2009 [Interleukin-18 expression in peripheral blood mononuclear cells in children with steroid-resistant nephrotic syndrome]. Steroids 82-89 interleukin 18 Homo sapiens 1-15 19342691-0 2009 Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. Steroids 16-23 myeloid differentiation primary response gene 88 Mus musculus 101-106 19342691-12 2009 We conclude that cooperative signaling between IFN-gamma and TLR4/MyD88 constitutes a previously unrecognized pathway that regulates macrophage-dependent steroid-resistant AHR. Steroids 154-161 myeloid differentiation primary response gene 88 Mus musculus 66-71 19429444-2 2009 The cardiotonic steroid bufalin enhances vitamin D-induced differentiation of leukemia cells and VDR transactivation activity. Steroids 16-23 vitamin D receptor Homo sapiens 97-100 18926804-8 2009 RDH-E2 is a member of the short-chain dehydrogenase/reductase (SDR) superfamily of proteins, and is most closely related to the group of SDRs comprised of both NAD(+)- and NADP(+)-dependent enzymes with activities toward retinoid and steroid substrates. Steroids 234-241 short chain dehydrogenase/reductase family 16C member 5 Homo sapiens 0-6 18771815-5 2009 Using a steroid-hormone-inducible system, we had previously shown that a protein-stability-enhancing mutation in domain II of IAA1 (iaa1) impaired diverse auxin responses. Steroids 8-15 indole-3-acetic acid inducible Arabidopsis thaliana 126-130 18771815-5 2009 Using a steroid-hormone-inducible system, we had previously shown that a protein-stability-enhancing mutation in domain II of IAA1 (iaa1) impaired diverse auxin responses. Steroids 8-15 indole-3-acetic acid inducible Arabidopsis thaliana 132-136 19001530-6 2009 Therefore, the members of Shc proteins may function as mediators between tyrosine phosphorylation and steroid signaling in steroid-regulated cell proliferation and carcinogenesis. Steroids 102-109 SHC adaptor protein 1 Homo sapiens 26-29 19001530-6 2009 Therefore, the members of Shc proteins may function as mediators between tyrosine phosphorylation and steroid signaling in steroid-regulated cell proliferation and carcinogenesis. Steroids 123-130 SHC adaptor protein 1 Homo sapiens 26-29 19001530-7 2009 In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. Steroids 106-113 SHC adaptor protein 1 Homo sapiens 53-56 19001530-7 2009 In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. Steroids 106-113 SHC adaptor protein 1 Homo sapiens 84-87 19001530-7 2009 In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. Steroids 106-113 SHC adaptor protein 1 Homo sapiens 84-87 19001530-7 2009 In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. Steroids 106-113 SHC adaptor protein 1 Homo sapiens 84-87 19001530-7 2009 In this communication, we discuss the novel roles of Shc proteins, specifically p52(Shc) and p66(Shc), in steroid hormone-regulated cancers and a novel molecular mechanism by which redox signaling induced by p66(Shc) mediates steroid action via a non-genomic pathway. Steroids 226-233 SHC adaptor protein 1 Homo sapiens 53-56 19250214-0 2009 Sex steroids upregulate the IGF-1R in prostate cancer cells through a nongenotropic pathway. Steroids 4-12 insulin like growth factor 1 receptor Homo sapiens 28-34 19333155-1 2009 OBJECTIVES: This study is to assess the effectiveness of steroid injections to improve the clinical and electrodiagnostic (EDX) parameters associated with moderate and severe carpal tunnel syndrome (CTS). Steroids 57-64 transthyretin Homo sapiens 199-202 19333155-9 2009 DISCUSSION: Steroid injection is an effective method to improve clinical scales but has limited ability to restore nerve conduction in moderate or severe CTS. Steroids 12-19 transthyretin Homo sapiens 154-157 19022937-10 2009 Although UGT2B7 and UGT2B17 exhibited high, although converse, stereoselectivity in testosterone and epitestosterone glucuronidation, UGT2A1, an extrahepatic enzyme that is expressed mainly in the nasal epithelium, catalyzed the glucuronidation of both steroids at considerable rates and similar kinetics. Steroids 253-261 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 9-15 18845640-2 2009 The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol side-chain cleavage cytochrome P450 (CYP11A1) enzyme complex takes place in the inner mitochondrial membranes. Steroids 39-46 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 183-190 18845640-2 2009 The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholesterol side-chain cleavage cytochrome P450 (CYP11A1) enzyme complex takes place in the inner mitochondrial membranes. Steroids 104-111 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 183-190 18689976-6 2009 In addition, upregulation of Dkk2 was also observed in uteri treated with estrogen (estradiol-17beta) as well as in oil-induced artificial decidualization, indicating that the expression of Dkk2 could be induced by both steroid hormone (estrogen) and the process of decidualization. Steroids 220-235 dickkopf WNT signaling pathway inhibitor 2 Mus musculus 29-33 18689976-6 2009 In addition, upregulation of Dkk2 was also observed in uteri treated with estrogen (estradiol-17beta) as well as in oil-induced artificial decidualization, indicating that the expression of Dkk2 could be induced by both steroid hormone (estrogen) and the process of decidualization. Steroids 220-235 dickkopf WNT signaling pathway inhibitor 2 Mus musculus 190-194 18706658-1 2009 BACKGROUND: Among the neuroactive steroids, dehydroepiandrosterone sulfate (DHEA-S) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA)-system. Steroids 34-42 sulfotransferase family 2A member 1 Homo sapiens 76-82 19074549-9 2009 This, to our knowledge, is the first demonstration of a role for BRCA1 in nuclear accumulation of a steroid hormone and the first demonstration that PRL has the potential to affect the cell cycle through effects on BRCA1. Steroids 100-115 BRCA1 DNA repair associated Homo sapiens 65-70 20429427-8 2009 FOXL2 has been suggested to be involved in the regulation of cholesterol homeostasis, steroid metabolism, apoptosis, reactive oxygen species detoxification and inflammation processes. Steroids 86-93 forkhead box L2 Homo sapiens 0-5 19548867-1 2009 The Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18 kDa mitochondrial protein primarily involved in steroid biosynthesis in both peripheral and glial cells. Steroids 153-160 translocator protein Homo sapiens 4-24 19548867-1 2009 The Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18 kDa mitochondrial protein primarily involved in steroid biosynthesis in both peripheral and glial cells. Steroids 153-160 translocator protein Homo sapiens 26-30 19548867-1 2009 The Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, is an 18 kDa mitochondrial protein primarily involved in steroid biosynthesis in both peripheral and glial cells. Steroids 153-160 translocator protein Homo sapiens 55-94 19548867-2 2009 It has been extensively reported that TSPO regulates the rate-limiting translocation of cholesterol from the outer to the inner mitochondrial membrane before its transformation by cytochrome P450(scc) into pregnenolone, which is further converted into an array of different steroids. Steroids 274-282 translocator protein Homo sapiens 38-42 19925417-8 2009 Furthermore, the recent recognition of IDE as a varicella zoster virus receptor and its putative involvement in muscle cell differentiation, steroid receptor signaling or proteasome modulation suggest that IDE is a multi-functional protein with broad and relevant roles in several basic cellular processes. Steroids 141-148 insulin degrading enzyme Homo sapiens 39-42 19925417-8 2009 Furthermore, the recent recognition of IDE as a varicella zoster virus receptor and its putative involvement in muscle cell differentiation, steroid receptor signaling or proteasome modulation suggest that IDE is a multi-functional protein with broad and relevant roles in several basic cellular processes. Steroids 141-148 insulin degrading enzyme Homo sapiens 206-209 19273238-0 2009 OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. Steroids 76-84 solute carrier family 51, alpha subunit Mus musculus 0-9 19273238-1 2009 The organic solute and steroid transporter, Ost alpha-Ost beta, is an unusual heteromeric carrier that appears to play a central role in the transport of bile acids, conjugated steroids, and structurally-related molecules across the basolateral membrane of many epithelial cells. Steroids 177-185 solute carrier family 51, alpha subunit Mus musculus 44-53 19273238-3 2009 In particular, the Ost alpha-deficient mice display a marked defect in intestinal bile acid and conjugated steroid absorption; a decrease in bile acid pool size and serum bile acid levels; altered intestinal, hepatic and renal disposition of known substrates of the transporter; and altered serum triglyceride, cholesterol, and glucose levels. Steroids 107-114 solute carrier family 51, alpha subunit Mus musculus 19-28 19056393-7 2009 The marked sex and estrous cycle-dependent differences in GFAP immunoreactivity density and in astrocyte number and morphology found in the rat hippocampus, suggest the involvement of sex steroid hormones in the sexually dimorphic functions of the hippocampus, and in the change in its activity during the estrous cycle. Steroids 188-204 glial fibrillary acidic protein Rattus norvegicus 58-62 19563167-0 2009 [Localization of CART-positive neurons in the amygdala and dependence of their immunoreactivity on the concentration of sex steroids]. Steroids 124-132 CART prepropeptide Rattus norvegicus 17-21 19563167-1 2009 During the study of all nuclear and paleocortical structures of amygdala, the CART-peptide (cocaine-amphetamine-regulated transcript) expressing neurons were for the first time demonstrated in this region, and their immunoreactivity was shown to be influenced by sex steroids. Steroids 267-275 CART prepropeptide Rattus norvegicus 78-82 19390203-0 2009 HLA-DR, -DQB typing of steroid-sensitive idiopathic nephrotic syndrome children in Taiwan. Steroids 23-30 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 0-12 18614256-7 2009 We propose that neurons expressing KiSS-1, NKB, substance P, dynorphin and ERalpha mRNA in the infundibular nucleus play an important role in sex-steroid feedback on gonadotropin secretion in the human. Steroids 146-153 KiSS-1 metastasis suppressor Homo sapiens 35-41 18619506-7 2009 Collectively, in the primate the reduction in the negative feedback control by ovarian steroids appears to be responsible for the aging changes in kisspeptin-GPR54 signaling and the elevated state of the LHRH-1 neuronal system. Steroids 87-95 KISS1 receptor Macaca mulatta 158-163 18775461-5 2009 The ARC metastin/kisspeptin neurons show no sex difference in their expression, which is suppressed by gonadal steroids in both sexes. Steroids 111-119 KiSS-1 metastasis-suppressor Rattus norvegicus 8-16 18789989-0 2009 Sex steroid control of hypothalamic Kiss1 expression in sheep and rodents: comparative aspects. Steroids 4-11 metastasis-suppressor KiSS-1 Ovis aries 36-41 19786734-11 2009 CONCLUSIONS: EBC measurements of IL-4, RANTES and IP-10 might be useful for predicting the steroid-mediated FEV1 improvement in asthma. Steroids 91-98 C-C motif chemokine ligand 5 Homo sapiens 39-45 19786734-11 2009 CONCLUSIONS: EBC measurements of IL-4, RANTES and IP-10 might be useful for predicting the steroid-mediated FEV1 improvement in asthma. Steroids 91-98 C-X-C motif chemokine ligand 10 Homo sapiens 50-55 19152650-9 2009 Our findings suggest with a reduction of steroid hormones following ovariectomy, alternatively activated macrophage markers (Fizz1 and Ym1) were reduced, with this effect being reversed with the administration of estrogen or progesterone; suggesting that with the reduction of steroid hormones macrophages are activated in a classical manner, promoting inflammation, whereas estrogen or progesterone are contributing toward macrophage activation in an alternative manner, driving wound repair, angiogenesis, and remodeling. Steroids 41-48 chitinase-like 3 Mus musculus 135-138 19152650-9 2009 Our findings suggest with a reduction of steroid hormones following ovariectomy, alternatively activated macrophage markers (Fizz1 and Ym1) were reduced, with this effect being reversed with the administration of estrogen or progesterone; suggesting that with the reduction of steroid hormones macrophages are activated in a classical manner, promoting inflammation, whereas estrogen or progesterone are contributing toward macrophage activation in an alternative manner, driving wound repair, angiogenesis, and remodeling. Steroids 41-57 chitinase-like 3 Mus musculus 135-138 18657352-5 2008 RESULTS: A significant increase of IL-10 and decrease of CCL2 serum levels was observed (p=0.0028 and 0.045 respectively) five days after the onset of steroid treatment but not after one month. Steroids 151-158 interleukin 10 Homo sapiens 35-40 18793874-7 2008 Foxp3 and IL-10 expression were increased significantly after intranasal steroid treatment (P<0.05). Steroids 73-80 interleukin 10 Homo sapiens 10-15 18632587-0 2008 The clinical course of steroid-sensitive childhood nephrotic syndrome is associated with a functional IL12B promoter polymorphism. Steroids 23-30 interleukin 12B Homo sapiens 102-107 18632587-8 2008 RESULTS: Children with the steroid-dependent course are at a significantly higher frequency homozygous for one IL12B allele compared to children without steroid dependence (46.7% and 17.6%, respectively). Steroids 27-34 interleukin 12B Homo sapiens 111-116 18617608-7 2008 A comparison of the two activities demonstrated the strength and temporal status of PKC regulation by steroid hormones in vivo. Steroids 102-118 protein kinase C, gamma Rattus norvegicus 84-87 8114512-12 1994 We conclude that human lung produces GM-CSF in vitro and that antiinflammatory steroids are potent and effective inhibitors of the production of this cytokine. Steroids 79-87 colony stimulating factor 2 Homo sapiens 37-43 18594869-11 2008 Our results indicate that among children with steroid-sensitive NS, there is an association with response to IVCP therapy and combination of GSTP1 Val105 polymorphism and the null genotypes of GSTT1 and GSTM1. Steroids 46-53 glutathione S-transferase theta 1 Homo sapiens 193-198 21913674-4 2011 OHPCBs also interact with a human hydroxysteroid sulfotransferase that plays a role in the sulfation of endogenous alcohol-containing steroid hormones and bile acids (i.e., hSULT2A1). Steroids 134-150 sulfotransferase family 2A member 1 Homo sapiens 173-181 8265621-4 1993 Enzymatic studies show a requirement for lipid, detergent, and cytochrome b5 for the 6 beta-hydroxylation of steroids and the N-oxidation of nifedipine. Steroids 109-117 cytochrome b5 type A Homo sapiens 63-76 18984794-6 2008 Neoplastic interstitial cells were immunoreactive for Melan A, consistent with reports of Melan A expression in steroid hormone-producing tissue. Steroids 112-127 melan-A Homo sapiens 90-97 21715713-5 2011 Results showed that oviduct-specific levels of avidin, ovalbumin, ovomucin, lysozyme, ESR1, and PGR gene expression were significantly elevated in steroid hormone-treated OECs compared with those of untreated cells (P < 0.05). Steroids 147-162 ovalbumin (SERPINB14) Gallus gallus 55-64 7504265-6 1993 This possibility--i.e., gender-specific determination of LHRH neurons coexpressing GAL--was evaluated by neonatal manipulation of hypothalamic steroid imprinting. Steroids 143-150 gonadotropin releasing hormone 1 Rattus norvegicus 57-61 21715713-5 2011 Results showed that oviduct-specific levels of avidin, ovalbumin, ovomucin, lysozyme, ESR1, and PGR gene expression were significantly elevated in steroid hormone-treated OECs compared with those of untreated cells (P < 0.05). Steroids 147-162 progesterone receptor Gallus gallus 96-99 21934016-6 2011 Active immunization against VIP enhanced reproductive parameters as manifested by increased semen quality, plasma steroid levels, and mRNA gene expression of hypothalamic gonadotropin-releasing hormone-I, pituitary follicle-stimulating hormone, pituitary luteinizing hormone (LH), and decreased mRNA gene expression of hypothalamic VIP, pituitary prolactin, and testicular LH receptor. Steroids 114-121 vasoactive intestinal peptide Gallus gallus 28-31 18847488-1 2008 BACKGROUND: The organic solute transporter (OSTalpha-OSTbeta) is a heteromeric transporter that is expressed on the basolateral membrane of epithelium in intestine, kidney, liver, testis and adrenal gland and facilitates efflux of bile acids and other steroid solutes. Steroids 252-259 solute carrier family 51 subunit alpha Homo sapiens 44-52 8259745-2 1993 PURPOSE: The activity of phenylethanolamine-N-methyl-transferase (PNMT) and catechol-O-methyl-transferase (COMT) was studied in uterine homogenates from adult female Wistar rats with normal cycles and that had been ovariectomized, adrenalectomized, and steroid-treated. Steroids 253-260 phenylethanolamine-N-methyltransferase Rattus norvegicus 25-64 18641401-7 2008 The variant HAL allele likewise appeared to modify the SCC risk associated with glucocorticoid steroid usage (P for interaction = 0.0004). Steroids 95-102 histidine ammonia-lyase Homo sapiens 12-15 18614772-1 2008 Classically, infants with mutations in NPHS1, which encodes nephrin, present with nephrotic syndrome within the first 3 mo of life (congenital nephrotic syndrome of the Finnish-type), and children with mutations in NPHS2, which encodes podocin, present later with steroid-resistant nephrotic syndrome. Steroids 264-271 NPHS1 adhesion molecule, nephrin Homo sapiens 39-44 18614772-3 2008 Whether NPHS1 mutations similarly account for some cases of childhood steroid-resistant nephrotic syndrome is unknown. Steroids 70-77 NPHS1 adhesion molecule, nephrin Homo sapiens 8-13 18774166-3 2008 OBJECTIVE: We sought to determine whether steroids modulate albuterol-induced beta(2)-AR tolerance in human small airways. Steroids 42-50 adrenoceptor beta 2 Homo sapiens 78-88 21763405-2 2011 In macaques, ovarian steroid administration to ovariectomized (Ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as TPH2 (tryptophan hydroxylase 2), SERT (serotonin reuptake transporter), and the 5HT1A autoreceptor. Steroids 21-28 tryptophan hydroxylase 2 Homo sapiens 188-192 21763405-2 2011 In macaques, ovarian steroid administration to ovariectomized (Ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as TPH2 (tryptophan hydroxylase 2), SERT (serotonin reuptake transporter), and the 5HT1A autoreceptor. Steroids 21-28 tryptophan hydroxylase 2 Homo sapiens 194-218 21763405-13 2011 In summary, long-term ovarian steroid loss resulted in fewer serotonin neurons and overall lower Fev, TPH2, SERT, and 5HT1A gene expression. Steroids 30-37 tryptophan hydroxylase 2 Homo sapiens 102-106 8404655-16 1993 These data suggest that ovarian steroid hormones act directly on the gonadotrope to augment alpha and FSH-beta mRNA responses to GnRH. Steroids 32-39 gonadotropin releasing hormone 1 Rattus norvegicus 129-133 18547597-6 2008 A comparison between SPE methods with betaCD and Oasis HLB as a conventional cartridge showed that the extraction efficiency of polar steroids was significantly increased in the betaCD experiment, which has no connection with different polarity of steroid molecules. Steroids 134-142 cAMP responsive element binding protein 3 like 1 Homo sapiens 49-54 18547597-6 2008 A comparison between SPE methods with betaCD and Oasis HLB as a conventional cartridge showed that the extraction efficiency of polar steroids was significantly increased in the betaCD experiment, which has no connection with different polarity of steroid molecules. Steroids 134-141 cAMP responsive element binding protein 3 like 1 Homo sapiens 49-54 8413674-2 1993 We report here a comparative analysis of the X-ray structures of five conformationally different steroids in complex with the Fab" fragment of an anti-progesterone antibody DB3 at 2.7 A. Steroids 97-105 FA complementation group B Homo sapiens 126-129 21819971-0 2011 Circadian Clock genes Per2 and clock regulate steroid production, cell proliferation, and luteinizing hormone receptor transcription in ovarian granulosa cells. Steroids 46-53 period circadian regulator 2 Homo sapiens 22-26 8255184-0 1993 Circulating gonadal steroid hormones regulate estrogen receptor mRNA in the male rat forebrain. Steroids 20-36 estrogen receptor 1 Rattus norvegicus 46-63 21849544-8 2011 This indicates a sex steroid-dependent plasticity of spinal KOR functionality, which could explain the greater analgesic potency of KOR agonists in women versus men. Steroids 21-28 opioid receptor kappa 1 Homo sapiens 60-63 21849544-8 2011 This indicates a sex steroid-dependent plasticity of spinal KOR functionality, which could explain the greater analgesic potency of KOR agonists in women versus men. Steroids 21-28 opioid receptor kappa 1 Homo sapiens 132-135 21621594-5 2011 Ltf, Cbll1 and Lias expression changed specifically in response to the calcineurin inhibitors, Fmo2 and 9630033F20Rik in response to the antimetabolites, Krt8, Gjb1, Hmha1 and Sfrs7 in response to the steroids, and Gbp1 and Mup5 in response to the alkylator. Steroids 201-209 Casitas B-lineage lymphoma-like 1 Mus musculus 5-10 18562571-6 2008 The model suggests that treatment with sirolimus plus steroids is more efficacious and less costly than regimens consisting of a CNI, mycophenolate mofetil, and steroids; therefore, CNI withdrawal not only shows potential for long-term clinical benefits but also is expected to be cost-saving over a patient"s life compared with the most commonly prescribed CNI-containing regimens. Steroids 54-62 calcineurin binding protein 1 Homo sapiens 182-185 18562571-6 2008 The model suggests that treatment with sirolimus plus steroids is more efficacious and less costly than regimens consisting of a CNI, mycophenolate mofetil, and steroids; therefore, CNI withdrawal not only shows potential for long-term clinical benefits but also is expected to be cost-saving over a patient"s life compared with the most commonly prescribed CNI-containing regimens. Steroids 54-62 calcineurin binding protein 1 Homo sapiens 182-185 18562571-6 2008 The model suggests that treatment with sirolimus plus steroids is more efficacious and less costly than regimens consisting of a CNI, mycophenolate mofetil, and steroids; therefore, CNI withdrawal not only shows potential for long-term clinical benefits but also is expected to be cost-saving over a patient"s life compared with the most commonly prescribed CNI-containing regimens. Steroids 161-169 calcineurin binding protein 1 Homo sapiens 182-185 18562571-6 2008 The model suggests that treatment with sirolimus plus steroids is more efficacious and less costly than regimens consisting of a CNI, mycophenolate mofetil, and steroids; therefore, CNI withdrawal not only shows potential for long-term clinical benefits but also is expected to be cost-saving over a patient"s life compared with the most commonly prescribed CNI-containing regimens. Steroids 161-169 calcineurin binding protein 1 Homo sapiens 182-185 21621594-5 2011 Ltf, Cbll1 and Lias expression changed specifically in response to the calcineurin inhibitors, Fmo2 and 9630033F20Rik in response to the antimetabolites, Krt8, Gjb1, Hmha1 and Sfrs7 in response to the steroids, and Gbp1 and Mup5 in response to the alkylator. Steroids 201-209 lipoic acid synthetase Mus musculus 15-19 8255184-4 1993 This study examined whether circulating male gonadal steroid hormones have a role in the regulation of estrogen receptor mRNA in brain regions critical for the expression of male reproductive behavior. Steroids 53-60 estrogen receptor 1 Rattus norvegicus 103-120 8255184-7 1993 Tissue sections were hybridized to an 35S-labeled 850 base cDNA probe, complementary primarily to the steroid binding domain of the estrogen receptor mRNA. Steroids 102-109 estrogen receptor 1 Rattus norvegicus 132-149 18625316-7 2008 Progesterone and R5020 had similar IC(50) values; steroids 8a, 8f and 8c bind to the progesterone receptor with RBAs of 100%, whereas 8e, 8b and 8d have RBA values <100%. Steroids 50-58 progesterone receptor Mus musculus 85-106 18625316-9 2008 Having demonstrated in this study that steroids 8a-8f bind to the PR, we also evaluated the receptor"s selectivity, since some progesterone derivatives bind to AR, MR, GR receptors. Steroids 39-47 progesterone receptor Mus musculus 66-68 8255184-9 1993 Estrogen receptor mRNA-containing neurons were observed in all brain regions previously shown by steroid hormone autoradiography to concentrate estrogen. Steroids 97-112 estrogen receptor 1 Rattus norvegicus 0-17 18625316-17 2008 The overall data showed that steroids 8a, 8f, 8e and 8c have a high and selective binding activity to the PR. Steroids 29-37 progesterone receptor Mus musculus 106-108 8255184-11 1993 This study shows that circulating gonadal steroids down-regulate steady state levels of estrogen receptor mRNA within specific brain regions, and thereby have the potential to regulate the sensitivity of particular target regions in the CNS to estrogen. Steroids 42-50 estrogen receptor 1 Rattus norvegicus 88-105 21729454-3 2011 This study aimed to investigate the structural changes and immunohistochemical localisation of epidermal growth factor receptor in rat vocal folds following anabolic steroid administration, and also to assess the effect of anti-androgens. Steroids 166-173 epidermal growth factor receptor Rattus norvegicus 95-127 18644453-6 2008 In order to study the mechanism of action of 11a-11d, we also determined the capacity of these steroids to bind to the androgen receptor (AR) present in the rat prostate cytosol using labeled mibolerone as a tracer. Steroids 95-103 androgen receptor Rattus norvegicus 119-136 18644453-6 2008 In order to study the mechanism of action of 11a-11d, we also determined the capacity of these steroids to bind to the androgen receptor (AR) present in the rat prostate cytosol using labeled mibolerone as a tracer. Steroids 95-103 androgen receptor Rattus norvegicus 138-140 18753370-5 2008 Using an ovariectomized, gonadal steroid-replacement regimen, which reliably generates an LH surge, approximately 30% of RP3V kisspeptin neurons were found to express c-FOS in surging mice compared with 0% in nonsurging controls. Steroids 33-40 KiSS-1 metastasis-suppressor Mus musculus 126-136 7951525-0 1993 Diagnostic study of a synthetic human corticotropin-releasing hormone (hCRH) in healthy adult males: its plasma pharmacokinetics and the effects on the urinary excretion of steroid hormones. Steroids 173-189 corticotropin releasing hormone Homo sapiens 38-69 18622263-1 2008 OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. Steroids 156-163 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 18-65 8217882-2 1993 The inhibition constants for 17 alpha-hydroxylase and C17,20-lyase with 5-ene-precursors of C21-steroids were 96 and 12.4 mumol/l, respectively. Steroids 96-104 cytokine like 1 Homo sapiens 54-57 18622263-1 2008 OBJECTIVES: Human uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7) plays important roles in the metabolism of some clinical drugs, carcinogens, and steroid hormones. Steroids 156-163 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 67-73 18495818-2 2008 The NCR-1 and -2 (NPC1-related) intracellular cholesterol transporters function redundantly in preventing dauer arrest, presumably by regulating the availability of substrates for steroid hormone synthesis. Steroids 180-195 NPC intracellular cholesterol transporter 1 homolog 1 Caenorhabditis elegans 4-16 18495818-7 2008 Interestingly, sterols that rescued hsd-1 defects also bypassed the need for the NCR-1 and/or -2 functions, suggesting that HSD-1-mediated steroid hormone production is an important functional output of the NCR transporters. Steroids 139-154 NPC intracellular cholesterol transporter 1 homolog 1 Caenorhabditis elegans 81-96 21773966-6 2011 In contrast, an in vitro experiment performed on isolated cells of adrenal cortex clearly showed increased production of both steroids in response to ACTH in Homer 1 KO cells, which is in line with an ~8-fold increase in the expression of ACTH receptor mRNA in the adrenal cortex of these mutants. Steroids 126-134 melanocortin 2 receptor Mus musculus 239-252 21774357-1 2011 Sex steroid hormones play important roles in bone metabolism through the functions of its specific nuclear receptors, estrogen receptors(ERs) and androgen receptor (AR). Steroids 4-20 androgen receptor Mus musculus 146-163 21774357-1 2011 Sex steroid hormones play important roles in bone metabolism through the functions of its specific nuclear receptors, estrogen receptors(ERs) and androgen receptor (AR). Steroids 4-20 androgen receptor Mus musculus 165-167 7689953-5 1993 In HFCM from cells treated with vehicle, GH, insulin, epidermal growth factor, steroid hormones, or forskolin, IGF-II induced the select loss of detectable IGFBP-4 during the assay. Steroids 79-95 insulin like growth factor 2 Homo sapiens 111-117 22049681-4 2011 In recent years, it has been found that Kiss1/GPR54 system, which may influence GnRH secretion evidently, is regulated by both melatonin and feedback action of gonadal steroid hormones. Steroids 168-184 KiSS-1 metastasis suppressor Homo sapiens 40-45 18524572-1 2008 The human type 1 (placenta, breast tumors) and type 2 (gonads, adrenals) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) are key enzymes in biosynthesis of all active steroid hormones. Steroids 188-204 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 85-129 18524572-1 2008 The human type 1 (placenta, breast tumors) and type 2 (gonads, adrenals) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) are key enzymes in biosynthesis of all active steroid hormones. Steroids 188-204 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 131-140 18502975-6 2008 To elucidate the early molecular events controlled by RGA during flower development, we performed whole-genome microarray analysis to identify genes in response to the steroid-inducible activation of RGA in ga1-3 rgl2 rga 35S:RGA-GR. Steroids 168-175 GRAS family transcription factor family protein Arabidopsis thaliana 54-57 21508898-1 2011 BACKGROUND: Recurrent glomerulonephritis (GN) remains an important cause of kidney allograft loss and whether rapid discontinuation of steroids (RDS) is associated with a higher risk of recurrence is not known. Steroids 135-143 peripherin 2 Homo sapiens 145-148 18502975-6 2008 To elucidate the early molecular events controlled by RGA during flower development, we performed whole-genome microarray analysis to identify genes in response to the steroid-inducible activation of RGA in ga1-3 rgl2 rga 35S:RGA-GR. Steroids 168-175 GRAS family transcription factor family protein Arabidopsis thaliana 200-203 7507291-0 1993 Relationship between follicular fluid levels of insulin-like growth factor binding protein-1 and sex steroids from normal human ovarian follicles. Steroids 101-109 insulin like growth factor binding protein 1 Homo sapiens 48-92 18502975-6 2008 To elucidate the early molecular events controlled by RGA during flower development, we performed whole-genome microarray analysis to identify genes in response to the steroid-inducible activation of RGA in ga1-3 rgl2 rga 35S:RGA-GR. Steroids 168-175 GRAS family transcription factor family protein Arabidopsis thaliana 218-221 18502975-6 2008 To elucidate the early molecular events controlled by RGA during flower development, we performed whole-genome microarray analysis to identify genes in response to the steroid-inducible activation of RGA in ga1-3 rgl2 rga 35S:RGA-GR. Steroids 168-175 GRAS family transcription factor family protein Arabidopsis thaliana 200-203 18502975-10 2008 Further expression analysis through activation of RGA by steroid induction combined with cycloheximide identified eight genes as immediate targets of RGA. Steroids 57-64 GRAS family transcription factor family protein Arabidopsis thaliana 50-53 18502975-10 2008 Further expression analysis through activation of RGA by steroid induction combined with cycloheximide identified eight genes as immediate targets of RGA. Steroids 57-64 GRAS family transcription factor family protein Arabidopsis thaliana 150-153 21539887-6 2011 Ovariectomized Axl/Tyro3 null mice, however, demonstrated an impaired ability to mount a steroid-induced LH surge. Steroids 89-96 TYRO3 protein tyrosine kinase 3 Mus musculus 19-24 8339285-12 1993 Finally, treatment of hpg/hpg scid/scid host mice with the androgenic steroid hormone precursor, dehydroepiandrosterone, resulted in GC tumor formation in the tumor-susceptible ovary grafts. Steroids 70-85 gonadotropin releasing hormone 1 Mus musculus 22-25 21365285-3 2011 We engineered the UFO1 promoter into an existing yeast bioreporter that employs human genes for detection of steroid hormone-disrupting compounds in water bodies. Steroids 109-124 SCF ubiquitin ligase complex subunit UFO1 Saccharomyces cerevisiae S288C 18-22 18280022-3 2008 This review summarizes studies showing the effect of DHEA and DHEAS on neurotransmitter systems at different levels (metabolism, release, reuptake, receptor activation), as well as the activation of voltage-gated ion channels and calcium homeostasis, showing the variety of effects that these steroids exert on those systems, allowing the discussion of its mechanisms of action and its relevance to psychiatric disorders. Steroids 293-301 sulfotransferase family 2A member 1 Homo sapiens 62-67 18386260-7 2008 RESULTS: We found that purine-rich element binding protein (PUR)alpha was significantly repressed not only in NMPs but also in total protein and mRNA levels of LN96 cells in comparison to LNCaP cells under the same steroid deprived conditions. Steroids 215-222 purine rich element binding protein A Homo sapiens 60-69 21456035-0 2011 Interleukin-18 upregulation is associated with the use of steroids in patients with ulcerative colitis. Steroids 58-66 interleukin 18 Homo sapiens 0-14 8339285-12 1993 Finally, treatment of hpg/hpg scid/scid host mice with the androgenic steroid hormone precursor, dehydroepiandrosterone, resulted in GC tumor formation in the tumor-susceptible ovary grafts. Steroids 70-85 gonadotropin releasing hormone 1 Mus musculus 26-29 7901758-1 1993 Tyrosine aminotransferase (TAT), a prototypical steroid hormone-inducible gene, has been used extensively in studies of tissue-specific control of gene transcription. Steroids 48-63 tyrosine aminotransferase Rattus norvegicus 0-25 18292190-0 2008 Steroid hormones control circadian Elovl3 expression in mouse liver. Steroids 0-16 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 35-41 7901758-1 1993 Tyrosine aminotransferase (TAT), a prototypical steroid hormone-inducible gene, has been used extensively in studies of tissue-specific control of gene transcription. Steroids 48-63 tyrosine aminotransferase Rattus norvegicus 27-30 18292190-9 2008 Taken together, these data suggest that Elovl3 expression in mouse liver is under strict diurnal control by circulating steroid hormones such as glucocorticoids and androgens. Steroids 120-136 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3 Mus musculus 40-46 21276783-7 2011 In addition, BUD potently inhibited AKR1D1 and AKR1C4, the key steroid metabolizing enzymes in liver, which may disrupt endogenous steroid hormone metabolism and thus contribute to BUD-induced systemic effects. Steroids 63-70 aldo-keto reductase family 1 member C4 Homo sapiens 47-53 7903433-2 1993 Recent studies indicate that excitatory amino acids may play an important role in the regulation of GnRH secretion and gene expression by steroids. Steroids 138-146 gonadotropin releasing hormone 1 Rattus norvegicus 100-104 21276783-7 2011 In addition, BUD potently inhibited AKR1D1 and AKR1C4, the key steroid metabolizing enzymes in liver, which may disrupt endogenous steroid hormone metabolism and thus contribute to BUD-induced systemic effects. Steroids 131-146 aldo-keto reductase family 1 member C4 Homo sapiens 47-53 18325991-4 2008 We hypothesized that changes in circulating ovarian steroids during late pregnancy might induce expression of SOCS mRNAs, thus disrupting STAT5b-mediated prolactin signaling. Steroids 52-60 cytokine inducible SH2-containing protein Rattus norvegicus 110-114 8361335-2 1993 Recent evidence suggests that gonadal steroids are capable of regulating the expression of proenkephalin (PE) mRNA in the ventromedial hypothalamus (VMH) of female, but not male rats. Steroids 38-46 proenkephalin Rattus norvegicus 91-104 18325991-4 2008 We hypothesized that changes in circulating ovarian steroids during late pregnancy might induce expression of SOCS mRNAs, thus disrupting STAT5b-mediated prolactin signaling. Steroids 52-60 signal transducer and activator of transcription 5B Rattus norvegicus 138-144 21363930-0 2011 Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Steroids 38-46 KiSS-1 metastasis-suppressor Rattus norvegicus 14-19 21363930-2 2011 In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex steroids. Steroids 171-179 KiSS-1 metastasis-suppressor Rattus norvegicus 12-17 21363930-7 2011 Next, we tested whether Kiss1 in the MeA is regulated by the circulating sex steroid milieu. Steroids 77-84 KiSS-1 metastasis-suppressor Rattus norvegicus 24-29 21418337-9 2011 The difference in c-Fos expression after mating disappeared when the two groups were ovariectomised and received steroid replacement. Steroids 113-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 18-23 8413314-1 1993 Transgenic mice that express a 10-kilobase human FSH beta (hFSH beta) gene exclusively in pituitary gonadotropes were used to study the regulation of hFSH beta gene expression by gonadal steroids. Steroids 187-195 follicle stimulating hormone subunit beta Homo sapiens 150-159 18612231-9 2008 1% steroid- or 0.01% rapamycin-applied eyes both showed positive staining for keratin-4 and -7. Steroids 3-10 keratin 4 Homo sapiens 78-94 7684949-2 1993 Although serum PSA is an excellent prognostic indicator, an increasing number of factors were found to regulate the PSA expression of prostatic cancer cells, which include androgenic steroids, the growth factors (GFs) and the extracellular matrix. Steroids 183-191 kallikrein related peptidase 3 Homo sapiens 116-119 18373277-2 2008 During this process, the expression of P450scc (involved in steroid biosynthesis) was elevated at both the mRNA and protein levels as evident in RT-PCR, Western blots, and immunostaining. Steroids 60-67 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 39-46 20933336-2 2011 Since PMS might be caused by an alteration in the cyclical hormonal modifications and ovarian steroids are directly involved in the regulation of mood, affective and cognitive functions and influence neurotrophins expression, in particular the brain-derived neurotrophic factor (BDNF), we aimed to evaluate whether plasma BDNF levels in women with PMS differ from those of normally menstruating women without PMS. Steroids 94-102 brain derived neurotrophic factor Homo sapiens 244-277 20933336-2 2011 Since PMS might be caused by an alteration in the cyclical hormonal modifications and ovarian steroids are directly involved in the regulation of mood, affective and cognitive functions and influence neurotrophins expression, in particular the brain-derived neurotrophic factor (BDNF), we aimed to evaluate whether plasma BDNF levels in women with PMS differ from those of normally menstruating women without PMS. Steroids 94-102 brain derived neurotrophic factor Homo sapiens 279-283 20933336-2 2011 Since PMS might be caused by an alteration in the cyclical hormonal modifications and ovarian steroids are directly involved in the regulation of mood, affective and cognitive functions and influence neurotrophins expression, in particular the brain-derived neurotrophic factor (BDNF), we aimed to evaluate whether plasma BDNF levels in women with PMS differ from those of normally menstruating women without PMS. Steroids 94-102 brain derived neurotrophic factor Homo sapiens 322-326 8232252-5 1993 The present results suggest roles of I-15P not only in the transport of bile salts but also in the metabolisms of certain steroid hormones. Steroids 122-138 fatty acid binding protein 6 Rattus norvegicus 37-42 21215607-4 2011 Serum concentrations of SAA were significantly higher in sarcoidosis patients than controls (p<0.001), inversely correlated with FEV(1) and significantly higher in patients with subacute onset requiring prolonged and multiple steroid treatments (class 6 SCAC) than in patients with subacute onset not requiring therapy (class 4 SCAC) (p<0.001). Steroids 229-236 serum amyloid A1 cluster Homo sapiens 24-27 21273900-2 2011 Steroids are usually mixed with local anesthetics, which have positive effects that can aid the treatment of CTS by inhibiting the spontaneous discharge ability of excitable cells. Steroids 0-8 transthyretin Homo sapiens 109-112 18473744-4 2008 SULT 2A1 mainly sulfonates DHEA and some steroids, with hydroxy derivatives of polycyclic aromatic hydrocarbons. Steroids 41-49 sulfotransferase family 2A member 1 Homo sapiens 0-8 18331266-0 2008 Sex steroids and leptin regulate the "first Kiss" (KiSS 1/G-protein-coupled receptor 54 system) in human gonadotropin-releasing-hormone-secreting neuroblasts. Steroids 4-12 KiSS-1 metastasis suppressor Homo sapiens 51-57 18331266-7 2008 MAIN OUTCOME MEASURES: Regulation of KiSS-1/GPR54 expression in FNC-B4 was evaluated in response to sexual steroids and leptin. Steroids 107-115 KiSS-1 metastasis suppressor Homo sapiens 37-43 8232254-1 1993 Acyl-CoA-binding protein has been isolated independently by five different groups based on its ability to (1) displace diazepam from the GABAA receptor, (2) affect cell growth, (3) induce medium-chain acyl-CoA-ester synthesis, (4) stimulate steroid hormone synthesis, and (5) affect glucose-induced insulin secretion. Steroids 241-256 diazepam binding inhibitor Rattus norvegicus 0-24 8366134-7 1993 Based on the capacity of an anti-type 1 interleukin 1 receptor monoclonal antibody (35F5) to block 1,25 (OH)2 D3-enhanced 125I-interleukin 1 alpha binding, we conclude that this steroid augments type 1 interleukin 1 receptor expression. Steroids 178-185 interleukin 1 alpha Mus musculus 127-146 18390587-6 2008 Addition of human recombinant Anx-A1 to Dex-treated cells reversed the inhibitory effects of the steroids on anti-CD3/CD28-induced IL-2 production. Steroids 97-105 annexin A1 Homo sapiens 30-36 18390587-7 2008 Treatment of RA patients with steroid decreased Anx-A1 expression in T cells. Steroids 30-37 annexin A1 Homo sapiens 48-54 18390587-9 2008 These results provide evidence for a novel pathway by which steroids regulate the adaptive immune response and suggest that Anx-A1 may represent a target for the treatment of autoimmune diseases. Steroids 60-68 annexin A1 Homo sapiens 124-130 21533175-1 2011 Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown. Steroids 73-80 sulfotransferase family 2A member 1 Homo sapiens 33-38 8496956-0 1993 Three-dimensional structure of an anti-steroid Fab" and progesterone-Fab" complex. Steroids 39-46 FA complementation group B Homo sapiens 47-50 21209087-2 2011 The controlling step in steroid hormone biogenesis is the delivery of cholesterol from intracellular stores to the cytochrome P450 enzyme CYP11A1 in the mitochondrial matrix. Steroids 24-39 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 138-145 17971159-5 2008 In this context, the hypothalamic KiSS-1 system has been proven sensitive to the early organizing effects, as well as to the acute regulatory actions, of gonadal steroids: phenomena which are likely to play fundamental roles in the sexual differentiation of gonadotropin secretion, and its feedback regulation by androgen and oestrogen. Steroids 162-170 KiSS-1 metastasis suppressor Homo sapiens 34-40 21209087-11 2011 In conclusion, we have identified a novel androstenetriol that can interact with the CRAC domain of TSPO, can control hormonal and constitutive steroidogenesis, and may prove to be a useful tool in the therapeutic control of diseases of excessive steroid formation. Steroids 144-151 translocator protein Rattus norvegicus 100-104 8496956-0 1993 Three-dimensional structure of an anti-steroid Fab" and progesterone-Fab" complex. Steroids 39-46 FA complementation group B Homo sapiens 69-72 8496956-3 1993 Crystals of the unliganded Fab" and various steroid-Fab" complexes are isomorphous and belong to the hexagonal space group, P6(4)22, with unit cell dimensions of a = b = 135 A, c = 124 A. Steroids 44-51 FA complementation group B Homo sapiens 52-55 17709769-2 2008 Anabolic steroids have been widely used as growth promoters in feedlot cattle for over 50 yr. A growing body of evidence suggests that increased muscle levels of IGF-I and increased muscle satellite cell numbers play a role in anabolic steroid enhanced muscle growth. Steroids 9-17 IGFI Bos taurus 162-167 8496300-3 1993 The insulin-like growth factors (IGF-I and IGF-II) promote cellular growth and differentiation and have been proposed to participate in these cyclic endometrial events, acting as mediators of steroid hormones. Steroids 192-208 insulin like growth factor 2 Homo sapiens 43-49 17709769-2 2008 Anabolic steroids have been widely used as growth promoters in feedlot cattle for over 50 yr. A growing body of evidence suggests that increased muscle levels of IGF-I and increased muscle satellite cell numbers play a role in anabolic steroid enhanced muscle growth. Steroids 9-16 IGFI Bos taurus 162-167 17709769-5 2008 Consequently, this review will focus on the roles of IGF-I and IGFBP in the cellular and molecular mechanisms of action of anabolic steroids and TGF-beta and myostatin, respectively. Steroids 132-140 IGFI Bos taurus 53-58 21187059-3 2011 One of these substrates for hSULT2A1 is dehydroepiandrosterone (DHEA), a major circulating steroid hormone in humans that serves as precursor to both androgens and estrogens. Steroids 91-106 sulfotransferase family 2A member 1 Homo sapiens 28-36 20970125-1 2011 The messenger RNA of the DNA methyltransferases DNMT3a and DNMT3b are expressed temporally in the endometrium across the menstrual cycle, as is the steroid hormone regulation of DNMT1, DNMT3a, and DNMT3b. Steroids 148-163 DNA methyltransferase 1 Homo sapiens 178-183 8471066-4 1993 The anti-inflammatory steroids (dexamethasone, prednisolone and hydrocortisone) at 10(-9)-10(-6) M significantly suppressed the production of rat gro/CINC by the IL-1 beta-stimulated NRK-49F cells in a dose-dependent manner. Steroids 22-30 C-X-C motif chemokine ligand 1 Rattus norvegicus 146-149 21445843-8 2011 Here, we report that neuronal Ngb levels are strongly induced by the steroid hormone 17beta-estradiol. Steroids 69-84 neuroglobin Homo sapiens 30-33 18424411-4 2008 The expression of KISS-1gene was regulated by steroid hormone in different nuclei within the forebrain to control the reproduction in puberty. Steroids 46-61 KiSS-1 metastasis suppressor Homo sapiens 18-24 18683684-10 2008 RT-PCR showed that 48 hours after the stimulation the levels of mRNA fas/beta-actin of the steroid-treated SLE group and steroid induced ANFH group were 0.914 +/- 0.226 and 0.776 +/- 0.230 respectively, both significantly higher than those of the control groups (0.832 +/- 0. Steroids 91-98 POTE ankyrin domain family member F Homo sapiens 73-83 8471066-5 1993 The relative potencies of the inhibitory activity of the steroids on the rat gro/CINC production were dexamethasone > prednisolone > hydrocortisone. Steroids 57-65 C-X-C motif chemokine ligand 1 Rattus norvegicus 77-80 21199193-9 2011 Finally, we find that silencing ANGPTL7 during the glucocorticoid insult significantly affected the expression of other steroid-responsive proteins. Steroids 120-127 angiopoietin like 7 Homo sapiens 32-39 8485257-11 1993 Ovariectomy as well as LHRH antagonist treatment eliminated the effects of RU486 on ovarian steroid production. Steroids 92-99 gonadotropin releasing hormone 1 Rattus norvegicus 23-27 21199193-10 2011 These results indicate that ANGPTL7 modulates the trabecular meshwork"s ECM as well as the response of this tissue to steroids. Steroids 118-126 angiopoietin like 7 Homo sapiens 28-35 20853021-8 2011 In addition, we found that dexamethasone-induced FKBP51 expression in PBMCs was inversely correlated with improvement in lung function after treatment with orally administered prednisolone in six steroid-naive asthmatics. Steroids 196-203 FK506 binding protein 5 Mus musculus 49-55 17915335-3 2008 The present review summarizes results obtained in our lab using genetic males affected by the testicular feminization syndrome (Tfm) as experimental model, and that led to the identification of a role for non-aromatized gonadal steroids acting through the androgen receptor (AR) in the differentiation of olfactory cues processing in mice. Steroids 228-236 androgen receptor Mus musculus 256-273 17915335-3 2008 The present review summarizes results obtained in our lab using genetic males affected by the testicular feminization syndrome (Tfm) as experimental model, and that led to the identification of a role for non-aromatized gonadal steroids acting through the androgen receptor (AR) in the differentiation of olfactory cues processing in mice. Steroids 228-236 androgen receptor Mus musculus 275-277 18039789-7 2008 Ovarian steroids strongly repressed both TGF-beta2 and -beta3 in stroma but only TGF-beta2 in glands. Steroids 8-16 transforming growth factor beta 2 Homo sapiens 41-61 18039789-7 2008 Ovarian steroids strongly repressed both TGF-beta2 and -beta3 in stroma but only TGF-beta2 in glands. Steroids 8-16 transforming growth factor beta 2 Homo sapiens 41-50 18039789-8 2008 cAMP prevented inhibition by ovarian steroids of TGF-beta2 but not -beta3. Steroids 37-45 transforming growth factor beta 2 Homo sapiens 49-58 8497492-0 1993 Changes in phospholipase A2 activity of the rabbit ampullary epithelium by ovarian steroids. Steroids 83-91 phospholipase A2 Oryctolagus cuniculus 11-27 18039789-9 2008 In presence of ovarian steroids, MAPK inhibitors (p38 and ERK pathways) stimulated TGF-beta3 but inhibited TGF-beta2 expression. Steroids 23-31 transforming growth factor beta 2 Homo sapiens 107-116 8497492-6 1993 These results suggest that the effects on PLA2 activity of ovarian steroids could regulate the local production of PG which plays a role in both smooth muscle contractility and ciliary activity. Steroids 67-75 phospholipase A2 Oryctolagus cuniculus 42-46 8508557-0 1993 Effect of gonadal steroids on the production of IL-1 and IL-6 by blood mononuclear cells in vitro. Steroids 18-26 interleukin 1 alpha Homo sapiens 48-52 18073302-1 2008 CONTEXT: It has been proposed that dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function is lacking. Steroids 213-221 sulfotransferase family 2A member 1 Homo sapiens 94-99 21081692-2 2011 HSL is one of the key enzymes involved in steroid hormone synthesis, and ACTH, with mediation of the PKA pathway, increases its activity. Steroids 42-57 lipase E, hormone sensitive type Homo sapiens 0-3 21081692-10 2011 An increased level of HSL results in an enhanced supply of cholesterol required for steroid hormone synthesis. Steroids 84-99 lipase E, hormone sensitive type Homo sapiens 22-25 8508557-2 1993 We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA. Steroids 38-46 interleukin 1 alpha Homo sapiens 68-81 21193311-5 2011 With the previously reported PTP1B inhibitor trodusquemine, our study reveals steroids and triterpenoids with negatively charged phosphate, carboxylate, or sulfonate groups as novel pharmacophores of selective PTP inhibitors. Steroids 78-86 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 29-34 18193358-4 2008 We here analyzed by liquid chromatography-tandem mass spectrometry the levels of neuroactive steroids present in the sciatic nerve of male and female peripheral myelin protein 22 transgenic rats (PMP22(tg) rats; i.e., an experimental model of CMT1A) and of the corresponding wild-type littermates. Steroids 93-101 peripheral myelin protein 22 Rattus norvegicus 150-178 18193358-5 2008 We observed that, both in PMP22(tg) rats and in the wild types, the levels of neuroactive steroids, such as progesterone, tetrahydroprogesterone (THP), isopregnanolone (3beta,5alpha-THP), testosterone, dihydrotestosterone, and 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol) are sexually dimorphic. Steroids 90-98 peripheral myelin protein 22 Rattus norvegicus 26-31 8508557-2 1993 We investigated the effect of gonadal steroids on the production of interleukin-1 (IL-1) and IL-6, cytokines believed to be important in the pathogenesis of RA. Steroids 38-46 interleukin 1 alpha Homo sapiens 83-87 21264241-0 2011 Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination. Steroids 0-8 src homology 2 domain-containing transforming protein C1 Mus musculus 21-27 8281894-5 1993 Steroids play a dose dependent inhibitory role perhaps via GIF (Glucocorticoid Increasing Factor) and cytokines (IL 1). Steroids 0-8 interleukin 1 alpha Homo sapiens 113-117 21094146-8 2011 The expression of StAR and MLN64 was aberrant in two skin disorders, psoriasis and atopic dermatitis, that are commonly treated with cortisol, suggesting dysregulation of epidermal steroid synthesis in these patients. Steroids 181-188 StAR related lipid transfer domain containing 3 Homo sapiens 27-32 18223326-2 2008 In this report, we assessed the potential of hydroxyl-delta-5-steroid dehydrogenase (HSD3B1), an enzyme that catalyzes the oxidative conversion of delta-5-3 beta-hydroxy steroids to the delta-4-3-keto configuration and that is involved in steroid hormone synthesis, as a diagnostic trophoblastic marker. Steroids 239-254 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 85-91 8382211-0 1993 Elevated glutathione S-transferase gene expression is an early event during steroid-induced lymphocyte apoptosis. Steroids 76-83 hematopoietic prostaglandin D synthase Rattus norvegicus 9-34 18209989-4 2008 To prevent steroid side effects and most importantly nephrotoxicity, the roles of antimetabolites such as mycophenolate and calcineurin inhibitor reduction have become more important. Steroids 11-18 calcineurin binding protein 1 Homo sapiens 124-145 21291396-3 2011 TSPO is ubiquitary expressed in peripheral tissues (steroid producing tissues, liver, heart, kidney, lung, immune system) and in lower levels in the central nervous system, where it is mainly located in glial cells, and in neurons. Steroids 52-59 translocator protein Homo sapiens 0-4 8419129-1 1993 Uterine epithelial cells (UEC) were isolated from cycling mice and cultured on Matrigel-coated nitrocellulose filters to determine their ability to secrete interleukin-1 alpha (IL-1 alpha) in response to ovarian steroids and induce prostaglandin (PG) secretion by uterine stromal cells (USC). Steroids 212-220 interleukin 1 alpha Mus musculus 156-175 21691099-5 2011 In addition, studies examining Ostalpha-Ostbeta substrate specificity have revealed that this transporter can also accept conjugated steroids, including some neurosteroids, and that the transporter is selectively expressed in steroidogenic cells of the brain and adrenal gland, suggesting a novel function for Ostalpha-Ostbeta. Steroids 133-141 solute carrier family 51 subunit alpha Homo sapiens 31-39 18036156-0 2008 Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice. Steroids 124-132 neuropeptide Y receptor Y1 Mus musculus 176-179 8419129-1 1993 Uterine epithelial cells (UEC) were isolated from cycling mice and cultured on Matrigel-coated nitrocellulose filters to determine their ability to secrete interleukin-1 alpha (IL-1 alpha) in response to ovarian steroids and induce prostaglandin (PG) secretion by uterine stromal cells (USC). Steroids 212-220 interleukin 1 alpha Mus musculus 177-187 21691099-5 2011 In addition, studies examining Ostalpha-Ostbeta substrate specificity have revealed that this transporter can also accept conjugated steroids, including some neurosteroids, and that the transporter is selectively expressed in steroidogenic cells of the brain and adrenal gland, suggesting a novel function for Ostalpha-Ostbeta. Steroids 133-141 solute carrier family 51 subunit alpha Homo sapiens 310-318 8112717-1 1993 In humans, sex steroids have been implicated in the regulation of hepatic and lipoprotein lipase activity. Steroids 15-23 lipoprotein lipase Homo sapiens 78-96 21047949-5 2011 Targeted silencing of PKCalpha, delta, and epsilon and PKD, using small interfering RNAs, resulted in deceases in basal and PMA-mediated StAR and steroid levels and demonstrated the importance of PKD in steroidogenesis. Steroids 146-153 protein kinase D1 Mus musculus 22-58 21047949-5 2011 Targeted silencing of PKCalpha, delta, and epsilon and PKD, using small interfering RNAs, resulted in deceases in basal and PMA-mediated StAR and steroid levels and demonstrated the importance of PKD in steroidogenesis. Steroids 146-153 protein kinase D1 Mus musculus 55-58 18637492-3 2008 Control of cell proliferation in the normal mammary gland is steroid hormone (estrogen and progestin)-dependent, involves complex interactions with other hormones, growth factors and cytokines and ultimately converges on activation of three proto-oncogenes (c-Myc, cyclin D1 and cyclin E1) that are rate limiting for the G1 to S phase transition during normal cell cycle progression. Steroids 61-76 cyclin D1 Mus musculus 265-274 18637492-3 2008 Control of cell proliferation in the normal mammary gland is steroid hormone (estrogen and progestin)-dependent, involves complex interactions with other hormones, growth factors and cytokines and ultimately converges on activation of three proto-oncogenes (c-Myc, cyclin D1 and cyclin E1) that are rate limiting for the G1 to S phase transition during normal cell cycle progression. Steroids 61-76 cyclin E1 Mus musculus 279-288 17988212-4 2008 Kisspeptins are potent secretagogues for GnRH, and the Kiss1 gene is a target for regulation by gonadal steroids (e.g., estradiol and testosterone), metabolic factors (e.g., leptin), photoperiod, and season. Steroids 104-112 KiSS-1 metastasis suppressor Homo sapiens 55-60 17988212-5 2008 Kiss1 neurons in the arcuate nucleus may regulate the negative feedback effect of gonadal steroids on GnRH and gonadotropin secretion in both sexes. Steroids 90-98 KiSS-1 metastasis suppressor Homo sapiens 0-5 1425586-8 1992 Homologs of the G-subdomains of this A chain, which occur in interacting regions of agrin, perlecan, laminin and sex steroid binding protein, may be involved in protein associations. Steroids 117-124 terribly reduced optic lobes Drosophila melanogaster 91-99 18690876-2 2008 PBR is involved in numerous biological functions, including steroid biosynthesis, mitochondrial oxidative phosporylation and cell proliferation. Steroids 60-67 translocator protein Homo sapiens 0-3 1329985-0 1992 Cyclic AMP regulates expression of the rat gene for steroid 17 alpha-hydroxylase/C17-20 lyase P-450 (CYP17) in rat Leydig cells. Steroids 52-59 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 101-106 18422165-2 2008 METHOD: Immunohistochemistry method was used to determine c-fos and c-myc expression in nasal polyps from patients with topical steroids treatment for 10-12 weeks and untreated patients. Steroids 128-136 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 58-63 18422165-3 2008 RESULT: The rate of c-fos expressing cases was 15% and the rate of c-myc expressing cases was 20% in nasal polyps from topical steroid treated patients, but in untreated patients, the rate of c-fos expressing cases was 80% and the rate of c-myc expressing cases was 85%. Steroids 127-134 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 192-197 18422165-5 2008 The c-fos and c-myc expression was remarkably downregulated in nasal polyps from topical steroid treated patients compared to untreated patients. Steroids 89-96 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 4-9 20675200-8 2011 In correlation with the attenuation of pain behaviors, the steroid prevented NMDAR subunits and PKCgamma mRNAs upregulation, did not modify the elevated ppD mRNA levels, but increased KOR expression. Steroids 59-66 protein kinase C, gamma Rattus norvegicus 96-104 1491396-0 1992 Effect of calcitonin or the anabolic steroid Decadurabolin on serum beta 2 microglobulin in osteoporotic postmenopausal women. Steroids 37-44 beta-2-microglobulin Homo sapiens 68-88 18022396-2 2007 In this study, diosgenin, a plant-derived steroid, was found to be effective in suppressing FAS expression in HER2-overexpressing breast cancer cells. Steroids 42-49 fatty acid synthase Homo sapiens 92-95 18086758-2 2007 We have genotyped nine putative functional single-nucleotide polymorphisms (SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 cases and 1,821 controls of Caucasian origin. Steroids 102-117 X-ray repair cross complementing 3 Homo sapiens 191-196 25214979-1 2011 BACKGROUND: Lidocaine can promote the apoptosis of eosinophils, which is normally delayed by IL-5; it has a good effect on serious steroid resistant asthma (SRA). Steroids 131-138 steroid receptor RNA activator 1 Homo sapiens 157-160 18086758-2 2007 We have genotyped nine putative functional single-nucleotide polymorphisms (SNP) in genes involved in steroid hormone synthesis (SRD5A2, CYP19A1, HSB17B1, and HSD17B4) and DNA repair (XRCC2, XRCC3, BRCA2, and RAD52) using two Australian ovarian cancer case-control studies, comprising a total of 1,466 cases and 1,821 controls of Caucasian origin. Steroids 102-117 BRCA2 DNA repair associated Homo sapiens 198-203 1491396-12 1992 Moreover it could be suggested that anabolic steroid and sCT affect beta 2m producing cells. Steroids 45-52 beta-2-microglobulin Homo sapiens 68-75 1478189-6 1992 The present study immunohistochemically supported our working hypothesis that the withdrawal of adrenal steroids by adrenalectomy enhances the islet cell sensitivity to exogenous administration of IL-1. Steroids 104-112 interleukin 1 alpha Homo sapiens 197-201 17889947-10 2007 The mode of action of salicylate involves disruption of StAR and liver GR, two key proteins critical for cortisol production and target tissue responsiveness to this steroid, respectively. Steroids 166-173 glucocorticoid receptor Oncorhynchus mykiss 71-73 20686809-9 2010 RESULTS: The Th1/Th2 ratio was lower in group A-1 [nephrotic-phase before steroid treatment (STx)] than in groups A-2 (remission-phase with STx) and A-3 (remission-phase without STx). Steroids 74-81 negative elongation factor complex member C/D Homo sapiens 13-16 20817116-1 2010 In holometabolous insects, the steroid hormone 20-hydroxyecdysone (20E), in coordination with juvenile hormone, regulates the major developmental events that promote larval development and the transition from the larval to the pupal stage. Steroids 31-38 Partner of Bursicon Drosophila melanogaster 227-232 1398018-0 1992 Mammalian GnRH involvement in prostaglandin F2 alpha and sex steroid hormones testicular release in two amphibian species: the anuran water frog, Rana esculenta, and the urodele crested newt, Triturus carnifex. Steroids 61-77 gonadotropin releasing hormone 1 Mus musculus 10-14 21069797-4 2010 CYP19A1, HSD3B1, and CYP17A1 transcripts, which encode key enzymes of steroid hormone biosynthesis, were quantified by real-time PCR (qPCR) and the degree of chromatin condensation was determined by DNase I protection assays. Steroids 70-85 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 21-28 17726140-4 2007 Expression of NMU mRNA at the hypothalamus was persistently detected along female postnatal development, with maximum levels in adulthood that fluctuated across the cycle and were modulated by ovarian steroids. Steroids 201-209 neuromedin U Rattus norvegicus 14-17 1398018-1 1992 The present work was carried out to study the in vitro effects of mammalian gonadotropin-releasing hormone (mGnRH) on Rana esculenta and Triturus carnifex testis production of prostaglandin F2 alpha (PGF2 alpha) and sex steroid hormones during the prereproduction, reproduction, and postreproduction periods. Steroids 220-236 gonadotropin releasing hormone 1 Mus musculus 108-113 17922695-4 2007 RESULTS: Female sex steroid hormones enhance the life cycle of mDCs, thus increasing the maturation and apoptosis, they also increase the production of interleukin (IL)-10 and IL-27 but only Pg increases the production of IL-13 and down regulates the secretion of IL-23. Steroids 20-36 interleukin 10 Homo sapiens 152-171 17715402-6 2007 DHEAS is identical to PS except that it contains a carbonyl oxygen instead of an acetyl group at C17 on the steroid D ring. Steroids 108-115 sulfotransferase family 2A member 1 Homo sapiens 0-5 20149142-3 2010 The formation of myometrial gap junctions follows an increase in the oestrogen to progesterone ratio indicating an important role of steroid hormones in regulating Cx43 expression at term. Steroids 133-149 gap junction protein alpha 1 Sus scrofa 164-168 1398018-8 1992 In addition, taken together with previous studies, they seem to suggest that the relationship found between mGnRH and PGF2 alpha or sex steroids could be widespread in amphibians. Steroids 136-144 gonadotropin releasing hormone 1 Mus musculus 108-113 17923326-2 2007 Several studies have provided evidence that some drugs and certain steroid hormones are substrates or inhibitors of P-gp. Steroids 67-83 phosphoglycolate phosphatase Mus musculus 116-120 1321437-4 1992 Here we report on the use of a steroid-inducible promoter expression system for the production of a permanently transfected clonal cell line expressing the alpha 1 beta 1 gamma 2L GABAA receptor subtype. Steroids 31-38 adrenoceptor alpha 1D Homo sapiens 156-163 17698983-12 2007 Expression of the LDL receptor is extinguished during luteinization, indicating dynamic regulation of cholesterol importation to maintain elevated steroid output by the CL. Steroids 147-154 low density lipoprotein receptor Sus scrofa 18-30 20876846-9 2010 This analysis identified transcription factors such as SP1, NFYA, FOXA2, IRF2, ESR1, and NOBOX as candidate regulators of gene expression in bovine endometrium treated with steroid hormones. Steroids 173-189 nuclear transcription factor Y subunit alpha Bos taurus 60-64 1451034-0 1992 Modulatory effect of steroid hormones on GnRH-induced LH secretion by cultured rat pituitary cells. Steroids 21-28 gonadotropin releasing hormone 1 Rattus norvegicus 41-45 22009963-0 2010 Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats. Steroids 69-76 Sp7 transcription factor Rattus norvegicus 29-36 22009963-0 2010 Dynamic expression of Runx2, Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats. Steroids 69-76 zinc finger protein 354C Rattus norvegicus 41-45 22009963-1 2010 OBJECTIVE: To study dynamic changes in gene expression and protein synthesis of runt-related transcription factor-2 (Runx2), Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats. Steroids 165-172 Sp7 transcription factor Rattus norvegicus 125-132 17582014-10 2007 Collectively, our results indicate that follicular maturation and gonadal steroids influence Calca and Calcr gene expression in the chicken ovary. Steroids 74-82 calcitonin receptor Gallus gallus 103-108 22009963-1 2010 OBJECTIVE: To study dynamic changes in gene expression and protein synthesis of runt-related transcription factor-2 (Runx2), Osterix and AJ18 in the femoral head of steroid-induced osteonecrosis in rats. Steroids 165-172 zinc finger protein 354C Rattus norvegicus 137-141 1451034-5 1992 The results show that the steroid hormones exert opposite effects on the release of LH induced by GnRH, which seems to be dependent upon the length of time the pituitary cells have been exposed to the steroids. Steroids 26-33 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 17976319-3 2007 Here we intend to investigate the profile of Th1/Th2-related cytokine transcriptions under yang-deficient conditions in a yang-deficient animal model by intramuscular injection of hydrocortisone (a kind of steroid hormone). Steroids 206-221 negative elongation factor complex member C/D Homo sapiens 45-48 1451034-5 1992 The results show that the steroid hormones exert opposite effects on the release of LH induced by GnRH, which seems to be dependent upon the length of time the pituitary cells have been exposed to the steroids. Steroids 201-209 gonadotropin releasing hormone 1 Rattus norvegicus 98-102 1451034-9 1992 GnRH-stimulated LH biosynthesis was also influenced by steroid treatment. Steroids 55-62 gonadotropin releasing hormone 1 Rattus norvegicus 0-4 17646279-2 2007 CYP2A6 is also expressed in sex steroid-responsive tissues such as breast, ovary, uterus, testis, and adrenal grand. Steroids 32-39 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 17656465-11 2007 Together, these results demonstrate that E(2)-dependent transcriptional activation of KiSS1 gene is mediated by ERalpha through the interaction of Sp1/Sp3 proteins with the GC-rich motifs of KiSS1 promoter, providing a molecular mechanism of how steroid hormone feedback regulates KiSS1 expression. Steroids 246-261 KiSS-1 metastasis-suppressor Mus musculus 86-91 20929581-14 2010 In this case, we have identified selenoamino acid metabolism and steroid biosynthesis as key pathways mediating the observed relationship between metabolic health and high-CLA beef. Steroids 65-72 clasper Mus musculus 172-175 17656465-11 2007 Together, these results demonstrate that E(2)-dependent transcriptional activation of KiSS1 gene is mediated by ERalpha through the interaction of Sp1/Sp3 proteins with the GC-rich motifs of KiSS1 promoter, providing a molecular mechanism of how steroid hormone feedback regulates KiSS1 expression. Steroids 246-261 KiSS-1 metastasis-suppressor Mus musculus 191-196 1618919-12 1992 These results indicate that PAF receptor coupling activates endometrial PtdIns(4,5)P2-specific phospholipase C only in the secretory phase of the menstrual cycle, suggesting that the PAF response may be under ovarian steroid regulation. Steroids 217-224 PCNA clamp associated factor Homo sapiens 28-31 17656465-11 2007 Together, these results demonstrate that E(2)-dependent transcriptional activation of KiSS1 gene is mediated by ERalpha through the interaction of Sp1/Sp3 proteins with the GC-rich motifs of KiSS1 promoter, providing a molecular mechanism of how steroid hormone feedback regulates KiSS1 expression. Steroids 246-261 KiSS-1 metastasis-suppressor Mus musculus 191-196 20660004-1 2010 BACKGROUND: HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Steroids 80-88 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 12-18 1618919-12 1992 These results indicate that PAF receptor coupling activates endometrial PtdIns(4,5)P2-specific phospholipase C only in the secretory phase of the menstrual cycle, suggesting that the PAF response may be under ovarian steroid regulation. Steroids 217-224 PCNA clamp associated factor Homo sapiens 183-186 17548088-1 2007 OBJECTIVE: To examine the effect of a low concentration of DHEAS on the expression of the androgen receptor, estrogen receptor alpha and beta, progesterone receptor, aromatase, 3-beta-hydroxysteroid dehydrogenase, and cyclooxygenase-2 in human preovulatory granulosa cells, and to measure their production of steroid hormones (estrone, estradiol, progesterone, androstenedione, and testosterone). Steroids 191-198 sulfotransferase family 2A member 1 Homo sapiens 59-64 1619035-2 1992 We present data on serum PP14 levels in 12 women (median age, 30.5 yr; range, 26-37 yr) with premature ovarian failure (POF) who conceived after ovum donation and embryo transfer with exogenous sex steroid support using transdermal (n = 5) or oral (n = 7) estradiol and vaginal (n = 8) or im (n = 4) progesterone. Steroids 198-205 progestagen associated endometrial protein Homo sapiens 25-29 17595317-8 2007 Furthermore, the steroid-induced tight junction sealing is attenuated in cells expressing dominant-negative forms of either Sgk or Akt, although the effect of blunting Sgk signaling was significantly greater. Steroids 17-24 serum/glucocorticoid regulated kinase 1 Homo sapiens 124-127 17622576-4 2007 Furthermore, after cleaving the specific [(125)I]IAF-photolabeled sigma-1 receptor in guinea pig and rat liver membranes and the pure guinea pig sigma-1 receptor with EndoLys-C and cyanogen bromide, the [(125)I]IAF label was identified both in a peptide containing steroid binding domain-like I (SBDLI) (amino acids 91-109) and in a peptide containing steroid binding domain-like II (SBDLII) (amino acids 176-194). Steroids 265-272 sigma non-opioid intracellular receptor 1 Rattus norvegicus 66-82 17622576-4 2007 Furthermore, after cleaving the specific [(125)I]IAF-photolabeled sigma-1 receptor in guinea pig and rat liver membranes and the pure guinea pig sigma-1 receptor with EndoLys-C and cyanogen bromide, the [(125)I]IAF label was identified both in a peptide containing steroid binding domain-like I (SBDLI) (amino acids 91-109) and in a peptide containing steroid binding domain-like II (SBDLII) (amino acids 176-194). Steroids 352-359 sigma non-opioid intracellular receptor 1 Rattus norvegicus 66-82 1613547-1 1992 We have found that the density of synapses in the stratum radiatum of the hippocampal CA1 region in the adult female rat is sensitive to estradiol manipulation and fluctuates naturally as the levels of ovarian steroids vary during the 5 d estrous cycle. Steroids 210-218 carbonic anhydrase 1 Rattus norvegicus 86-89 1597440-2 1992 This paper presents data identifying adenosine 3",5"-diphosphate (3",5"-ADP) as the small heat-stable factor essential for the active steroid binding complex of the adrenocortical pregnenolone-binding protein (PBP). Steroids 134-141 phosphatidylethanolamine binding protein 1 Bos taurus 180-208 17659348-8 2007 This finding opens the way for a promising therapeutic strategy, the use of pharmacological agents, such as ligands of the translocator protein (18 kDa) (TSPO; the former peripheral benzodiazepine receptor or PBR), to locally increase the synthesis of steroids with neuroprotective and neuroregenerative properties. Steroids 252-260 translocator protein Homo sapiens 123-152 17659348-8 2007 This finding opens the way for a promising therapeutic strategy, the use of pharmacological agents, such as ligands of the translocator protein (18 kDa) (TSPO; the former peripheral benzodiazepine receptor or PBR), to locally increase the synthesis of steroids with neuroprotective and neuroregenerative properties. Steroids 252-260 translocator protein Homo sapiens 154-158 17659348-8 2007 This finding opens the way for a promising therapeutic strategy, the use of pharmacological agents, such as ligands of the translocator protein (18 kDa) (TSPO; the former peripheral benzodiazepine receptor or PBR), to locally increase the synthesis of steroids with neuroprotective and neuroregenerative properties. Steroids 252-260 translocator protein Homo sapiens 209-212 1597440-2 1992 This paper presents data identifying adenosine 3",5"-diphosphate (3",5"-ADP) as the small heat-stable factor essential for the active steroid binding complex of the adrenocortical pregnenolone-binding protein (PBP). Steroids 134-141 phosphatidylethanolamine binding protein 1 Bos taurus 210-213 1597440-11 1992 Taken collectively, the data overwhelmingly demonstrate that 3",5"-ADP is in fact the molecule required by the PBP for high affinity steroid binding complex formation. Steroids 133-140 phosphatidylethanolamine binding protein 1 Bos taurus 111-114 1580447-0 1992 Prediction of steroid responsiveness in the idiopathic nephrotic syndrome using urinary retinol-binding protein and beta-2-microglobulin. Steroids 14-21 beta-2-microglobulin Homo sapiens 116-136 17702049-4 2007 Steroid ratios are expressed as multiples of the 75th centile (MoS), rather than multiples of the median, as most reference measurements were undetectable. Steroids 0-7 MOS proto-oncogene, serine/threonine kinase Homo sapiens 63-66 1580447-9 1992 Median urinary RBP and B2M, before treatment, were significantly higher in the steroid-unresponsive group than in the responsive group (P less than 0.01). Steroids 79-86 beta-2-microglobulin Homo sapiens 23-26 1580447-10 1992 In the steroid-responsive group, urinary RBP and B2M levels decreased significantly after remission (P less than 0.01). Steroids 7-14 beta-2-microglobulin Homo sapiens 49-52 17637799-4 2007 Introduction of this engineered ZFP TF into human or murine cells allowed expression of the chromosomal VEGF-A gene to be induced upon addition of mifepristone, a synthetic steroid analog. Steroids 173-180 vascular endothelial growth factor A Mus musculus 104-110 1580447-11 1992 In the steroid-unresponsive group, the likelihood ratios for urinary RBP greater than 4000 micrograms/g creatinine and for B2M greater than 3000 micrograms/g creatinine were 3.8 and 3.0, respectively. Steroids 7-14 beta-2-microglobulin Homo sapiens 123-126 1580447-12 1992 The probability was 100% that values of RBP of less than 1300 micrograms/g creatinine and B2M of less than 130 micrograms/g creatinine were from steroid-responsive patients. Steroids 145-152 beta-2-microglobulin Homo sapiens 90-93 1580447-13 1992 Multivariate analysis confirmed that higher urinary levels of RBP and B2M were associated with a lower likelihood of steroid responsiveness, independent of age and histologic diagnosis. Steroids 117-124 beta-2-microglobulin Homo sapiens 70-73 1580447-15 1992 Pretreatment urinary RBP and B2M levels may be helpful in identifying nephrotic patients who are more likely to be responsive to steroids. Steroids 129-137 beta-2-microglobulin Homo sapiens 29-32 1358447-9 1992 The steroid responsiveness of PNMT message production is specific for glucocorticoids. Steroids 4-11 phenylethanolamine-N-methyltransferase Rattus norvegicus 30-34 17579197-3 2007 OBJECTIVE: Our objective was to determine the impact of the H(268)Y polymorphism in the UGT2B7 gene on interindividual variation of serum levels of sex steroids and cortical bone dimensions. Steroids 152-160 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 88-94 1597160-4 1992 Collectively, these results suggest that clone 1D5 interacts with the steroid binding site of ER. Steroids 70-77 estrogen receptor 1 Rattus norvegicus 94-96 17519522-0 2007 Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity. Steroids 39-46 Janus kinase 2 Rattus norvegicus 120-134 1623572-6 1992 UST has an anti-shock effect like steroid hormone. Steroids 34-49 alpha-1-microglobulin/bikunin precursor Rattus norvegicus 0-3 17519522-0 2007 Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity. Steroids 39-46 Janus kinase 2 Rattus norvegicus 136-140 17519522-9 2007 Additionally, the results emphasize that PRL stimulation of adrenal steroid release may be mediated through Jak2 activity. Steroids 68-75 Janus kinase 2 Rattus norvegicus 108-112 1314085-5 1992 Using sedimentation gradient analysis, we showed that the interaction between hsp90 and the steroid binding subunit of MR is highly dependent upon the nature of the steroid ligand since the binding of aldosterone antagonists results in an easy release of hsp90. Steroids 92-99 heat shock protein 90 alpha family class A member 1 Homo sapiens 78-83 1314085-5 1992 Using sedimentation gradient analysis, we showed that the interaction between hsp90 and the steroid binding subunit of MR is highly dependent upon the nature of the steroid ligand since the binding of aldosterone antagonists results in an easy release of hsp90. Steroids 92-99 heat shock protein 90 alpha family class A member 1 Homo sapiens 255-260 17364147-0 2007 SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis. Steroids 32-39 suppressor of cytokine signaling 1 Mus musculus 0-6 17364147-8 2007 Together, these results show that sepsis increases steroid-induced thymic lymphoid cell apoptosis, which is associated with reduced SOCS-1 expression and increased Bax translocation to mitochondria. Steroids 51-58 suppressor of cytokine signaling 1 Mus musculus 132-138 1314085-5 1992 Using sedimentation gradient analysis, we showed that the interaction between hsp90 and the steroid binding subunit of MR is highly dependent upon the nature of the steroid ligand since the binding of aldosterone antagonists results in an easy release of hsp90. Steroids 165-172 heat shock protein 90 alpha family class A member 1 Homo sapiens 78-83 1314085-5 1992 Using sedimentation gradient analysis, we showed that the interaction between hsp90 and the steroid binding subunit of MR is highly dependent upon the nature of the steroid ligand since the binding of aldosterone antagonists results in an easy release of hsp90. Steroids 165-172 heat shock protein 90 alpha family class A member 1 Homo sapiens 255-260 17364147-8 2007 Together, these results show that sepsis increases steroid-induced thymic lymphoid cell apoptosis, which is associated with reduced SOCS-1 expression and increased Bax translocation to mitochondria. Steroids 51-58 BCL2-associated X protein Mus musculus 164-167 1541925-3 1992 There are several lines of evidence to suggest that the steroid effects might be mediated via a mechanism involving modulation of the GnRH signal-transduction system. Steroids 56-63 gonadotropin releasing hormone 1 Rattus norvegicus 134-138 1764058-5 1991 In mammary gland organ cultures from steroid-primed mice, the combinations of insulin + hydrocortisone and insulin + prolactin + hydrocortisone increased both prepro-EGF and beta-casein mRNA expression. Steroids 37-44 epidermal growth factor Mus musculus 166-169 17427185-2 2007 NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Steroids 31-38 nuclear receptor subfamily 4 group A member 2 Homo sapiens 0-5 17427185-2 2007 NR4A2 (Nurr1), a member of the steroid/thyroid hormone nuclear receptor superfamily, is essential for the neurogenesis and differentiation of dopaminergic neurons in the midbrain. Steroids 31-38 nuclear receptor subfamily 4 group A member 2 Homo sapiens 7-12 1954882-0 1991 Mullerian inhibiting substance production and cleavage is modulated by gonadotropins and steroids. Steroids 89-97 anti-Mullerian hormone Homo sapiens 0-30 1954882-8 1991 This study describes a form of post-translational regulation of MIS and shows that both transcription and processing of MIS may be differentially modulated by gonadotropins and sex steroids. Steroids 181-189 anti-Mullerian hormone Homo sapiens 64-67 1954882-8 1991 This study describes a form of post-translational regulation of MIS and shows that both transcription and processing of MIS may be differentially modulated by gonadotropins and sex steroids. Steroids 181-189 anti-Mullerian hormone Homo sapiens 120-123 1836352-0 1991 The gene expressions of macrophage colony-stimulating factor (MCSF) and MCSF receptor in the human myometrium during pregnancy: regulation by sex steroid hormones. Steroids 146-162 colony stimulating factor 1 Homo sapiens 24-60 17154301-1 2007 In cattle, leptin has been implicated in the control of ovarian function and has been shown to modulate steroid production by theca and granulosa cells in a number of species. Steroids 104-111 leptin Bos taurus 11-17 1836352-0 1991 The gene expressions of macrophage colony-stimulating factor (MCSF) and MCSF receptor in the human myometrium during pregnancy: regulation by sex steroid hormones. Steroids 146-162 colony stimulating factor 1 Homo sapiens 62-66 1836352-0 1991 The gene expressions of macrophage colony-stimulating factor (MCSF) and MCSF receptor in the human myometrium during pregnancy: regulation by sex steroid hormones. Steroids 146-162 colony stimulating factor 1 Homo sapiens 72-76 1836352-1 1991 We investigated the biological effect of sex-steroid hormones, secreted from the corpus luteum and placenta, on the induction of mRNA encoding macrophage colony-stimulating factor (MCSF) and c-fms proto-oncogene (MCSF receptor) in the human uterine myometrium. Steroids 45-52 colony stimulating factor 1 Homo sapiens 143-179 1836352-1 1991 We investigated the biological effect of sex-steroid hormones, secreted from the corpus luteum and placenta, on the induction of mRNA encoding macrophage colony-stimulating factor (MCSF) and c-fms proto-oncogene (MCSF receptor) in the human uterine myometrium. Steroids 45-52 colony stimulating factor 1 Homo sapiens 181-185 17438221-0 2007 Steroid-responsive neurologic relapses in a child with a proteolipid protein-1 mutation. Steroids 0-7 proteolipid protein 1 Homo sapiens 57-78 1836352-1 1991 We investigated the biological effect of sex-steroid hormones, secreted from the corpus luteum and placenta, on the induction of mRNA encoding macrophage colony-stimulating factor (MCSF) and c-fms proto-oncogene (MCSF receptor) in the human uterine myometrium. Steroids 45-52 colony stimulating factor 1 Homo sapiens 213-217 1836352-6 1991 These results indicate that sex steroid hormone secreted from the corpus luteum of pregnancy and/or placenta may be deeply involved in the hypertrophic change of uterus during pregnancy by inducing MCSF and MCSF receptor (c-fms proto-oncogene protein product) in the myometrium. Steroids 32-39 colony stimulating factor 1 Homo sapiens 198-202 1836352-6 1991 These results indicate that sex steroid hormone secreted from the corpus luteum of pregnancy and/or placenta may be deeply involved in the hypertrophic change of uterus during pregnancy by inducing MCSF and MCSF receptor (c-fms proto-oncogene protein product) in the myometrium. Steroids 32-39 colony stimulating factor 1 Homo sapiens 207-211 1664066-4 1991 Intense DBI-LI was observed in some endocrine, steroid-producing cells such as glomerular cells of the adrenal gland and Leydig cells of the of the testis. Steroids 47-54 diazepam binding inhibitor Rattus norvegicus 8-11 1928065-5 1991 Thus, the presence of immune deposits with a prominent C1q contribution identifies a group of cases that respond poorly to steroids and that, if light microscopy is considered in isolation, might otherwise be designated MCD. Steroids 123-131 complement C1q A chain Homo sapiens 55-58 17358057-5 2007 We investigated the steroid hydroxylating system from bovine adrenal glands, which consists of adrenodoxin (Adx), adrenodoxin reductase (AdR), and a cytochrome P450, CYP11A1. Steroids 20-27 ferredoxin reductase Bos taurus 114-135 17358057-5 2007 We investigated the steroid hydroxylating system from bovine adrenal glands, which consists of adrenodoxin (Adx), adrenodoxin reductase (AdR), and a cytochrome P450, CYP11A1. Steroids 20-27 ferredoxin reductase Bos taurus 137-140 21112864-1 2010 OBJECTIVE: Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body. Steroids 107-123 sulfotransferase family 2A member 1 Homo sapiens 77-83 1892851-11 1991 Hybridization analysis of the DNAf from the enriched NAPf demonstrates sequence homologies with the nuclear matrix DNA as well as with genomic sequences of the rapid steroid responding nuclear protooncogenes c-myc and c-jun. Steroids 166-173 MYC proto-oncogene, bHLH transcription factor Homo sapiens 208-213 20660818-6 2010 In normoxic animals, pregnancy and the sex steroid treatments significantly increased uterine artery estrogen receptor-alpha and progesterone receptor B expression. Steroids 43-50 estrogen receptor Ovis aries 101-124 20660818-8 2010 The results demonstrate that, in the ovine uterine artery, chronic hypoxia in pregnancy inhibits the sex steroid hormone-mediated adaptation of decreased myogenic tone by downregulating estrogen receptor-alpha expression, providing a mechanism linking hypoxia and maladaptation of uteroplacental circulation and an increased risk of preeclampsia in pregnancy. Steroids 105-120 estrogen receptor Ovis aries 186-209 17204549-3 2007 Kiss1 neurons in the AVPV appear to play a role in generating the preovulatory GnRH/LH surge, which occurs only in females and is organized perinatally by gonadal steroids. Steroids 163-171 KiSS-1 metastasis-suppressor Rattus norvegicus 0-5 17244199-4 2007 In previous studies, we have found that two of these nuclear receptor coactivators, steroid receptor coactivator-1 (SRC-1) and CREB-binding protein (CBP), are important in ER-mediated induction of PR in the VMN and in steroid-dependent behaviours. Steroids 84-91 CREB binding protein Rattus norvegicus 149-152 1661182-3 1991 At the level of the gonads, adrenal corticoids, pro-opiomelanocortin (POMC)-like peptides, and corticotropin-releasing factor (CRF) are reported to interfere with the stimulatory action of gonadotropins on sex steroid-producing cells. Steroids 210-217 corticotropin releasing hormone Homo sapiens 95-125 17332731-5 2007 Klotho can act as a circulating factor or hormone, which binds to a not yet identified high-affinity receptor and inhibits the intracellular insulin/insulin-like growth factor-1 (IGF-1) signaling cascade; klotho can function as a novel beta-glucuronidase, which deglycosylates steroid beta-glucuronides and the calcium channel transient receptor potential vallinoid-5 (TRPV5); as a cofactor essential for the stimulation of fibroblast growth factor (FGF) receptor by FGF23. Steroids 277-284 klotho Homo sapiens 0-6 1874169-10 1991 Tracer studies with radiolabeled steroid substrates suggested that IL-1-attenuated ovarian androsterone accumulation is due, if only in part, to inhibition of transformations catalyzed by (theca-interstitial) 17 alpha-hydroxylase/17:20 lyase, stimulation of theca-interstitial (or granulosa 20 alpha-hydroxysteroid dehydrogenase-mediated conversions, or both. Steroids 33-40 interleukin 1 alpha Homo sapiens 67-71 17332731-5 2007 Klotho can act as a circulating factor or hormone, which binds to a not yet identified high-affinity receptor and inhibits the intracellular insulin/insulin-like growth factor-1 (IGF-1) signaling cascade; klotho can function as a novel beta-glucuronidase, which deglycosylates steroid beta-glucuronides and the calcium channel transient receptor potential vallinoid-5 (TRPV5); as a cofactor essential for the stimulation of fibroblast growth factor (FGF) receptor by FGF23. Steroids 277-284 klotho Homo sapiens 205-211 19497023-7 2010 The results of this study demonstrate a serum-free culture system for buffalo granulosa cells and stimulatory effect of FSH but not LH on steroid hormone production by buffalo granulosa cells under these conditions. Steroids 138-153 follitropin subunit beta Bubalus bubalis 120-123 1770949-1 1991 The steroid-binding capacity of the adrenocortical pregnenolone-binding protein (PBP) is effectively destroyed by extreme temperature (boiling water for 2-5 min); however, the boiled preparation contains a factor that potentiates ligand binding when readded to native PBP. Steroids 4-11 phosphatidylethanolamine binding protein 1 Bos taurus 51-79 20720261-8 2010 CXCR4 gene expression was significantly downregulated by ovarian steroid hormones in endometrial epithelial. Steroids 65-81 C-X-C motif chemokine receptor 4 Homo sapiens 0-5 20720261-9 2010 These data suggest that steroid modulation of CXCR4 is defective in endometriosis, although the specific mechanism involved remains to be elucidated. Steroids 24-31 C-X-C motif chemokine receptor 4 Homo sapiens 46-51 20708777-3 2010 The aim of this study was to investigate the association of DNA polymorphisms within steroid synthesis genes (CYP11B2, CYP11B1) and the postoperative resolution of hypertension in Chinese patients undergoing adrenalectomy for aldosterone-producing adenomas (APA). Steroids 85-92 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 119-126 17213386-1 2007 The first and key enzyme controlling the synthesis of steroid hormones is cholesterol side chain cleavage cytochrome P450 (P450scc, CYP11A1). Steroids 54-70 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 117-121 17213386-1 2007 The first and key enzyme controlling the synthesis of steroid hormones is cholesterol side chain cleavage cytochrome P450 (P450scc, CYP11A1). Steroids 54-70 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 123-130 17213386-1 2007 The first and key enzyme controlling the synthesis of steroid hormones is cholesterol side chain cleavage cytochrome P450 (P450scc, CYP11A1). Steroids 54-70 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 132-139 1770949-1 1991 The steroid-binding capacity of the adrenocortical pregnenolone-binding protein (PBP) is effectively destroyed by extreme temperature (boiling water for 2-5 min); however, the boiled preparation contains a factor that potentiates ligand binding when readded to native PBP. Steroids 4-11 phosphatidylethanolamine binding protein 1 Bos taurus 81-84 1770949-1 1991 The steroid-binding capacity of the adrenocortical pregnenolone-binding protein (PBP) is effectively destroyed by extreme temperature (boiling water for 2-5 min); however, the boiled preparation contains a factor that potentiates ligand binding when readded to native PBP. Steroids 4-11 phosphatidylethanolamine binding protein 1 Bos taurus 268-271 1855463-4 1991 The transient expression of PEA messenger (m) RNA levels occurring normally in B cells was markedly inhibited by the presence of either 50 nM prednisolone or dexamethasone, both of which are glucocorticoids; other steroids, such as testosterone or the steroid-inactive metabolite androsterone, were ineffective. Steroids 214-222 proenkephalin Rattus norvegicus 28-31 17414062-1 2007 OBJECTIVES: Because functional changes of the pancreas during the ovarian cycle are not fully understood, effects of gonadal steroid hormones on pancreatic amylase content and secretion were investigated. Steroids 125-141 amylase 2a3 Rattus norvegicus 145-163 20545708-14 2010 CONCLUSION: Evidence of an increased GR-beta expression in epithelial cells following IL-17 stimulation suggests a possible role for Th17-associated cytokines in the mechanism of steroid hypo-responsiveness in asthmatic subjects. Steroids 179-186 interleukin 17A Homo sapiens 86-91 1855463-4 1991 The transient expression of PEA messenger (m) RNA levels occurring normally in B cells was markedly inhibited by the presence of either 50 nM prednisolone or dexamethasone, both of which are glucocorticoids; other steroids, such as testosterone or the steroid-inactive metabolite androsterone, were ineffective. Steroids 214-221 proenkephalin Rattus norvegicus 28-31 2048592-6 1991 Plasma levels of contraceptive steroids also were related to changes in the most extreme levels of antithrombin III. Steroids 31-39 serpin family C member 1 Homo sapiens 99-115 20573576-0 2010 Glucocorticoid receptor in the rat epididymis: expression, cellular distribution and regulation by steroid hormones. Steroids 99-115 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 0-23 17126340-0 2007 The expression of CD9 in the peri-implantation mouse uterus is upregulated in an ovarian steroid hormone-dependent manner. Steroids 89-104 CD9 antigen Mus musculus 18-21 2036964-2 1991 In the present study we evaluated that role of LHRH in this steroid-induced effect on opiate-responsiveness. Steroids 60-67 gonadotropin releasing hormone 1 Rattus norvegicus 47-51 20578895-10 2010 Also, routine use of prophylactic oral steroids with RAI therapy should be considered in GD patients without overt GO, but even more so in those at higher risks of eye complications such as smokers, old men, and those with severe hyperthyroidism or high TSH-R antibody titers. Steroids 39-47 thyroid stimulating hormone receptor Homo sapiens 254-259 20547883-1 2010 Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. Steroids 85-101 ferredoxin 1 Homo sapiens 23-35 17254722-14 2007 Summarizing these data it is obvious that DMT is a powerful anabolic steroid with selective androgen receptor modulators (SARM) like properties and some indications for toxic side effects. Steroids 69-76 androgen receptor Rattus norvegicus 92-109 2036964-6 1991 These results indicate that the LHRH secretory dynamics associated with the preovulatory surge of LH may serve to modulate opiate responsiveness and thereby could serve to couple behavioral, sensory, and autonomic events with this neuroendocrine response to gonadal steroids. Steroids 266-274 gonadotropin releasing hormone 1 Rattus norvegicus 32-36 1840919-2 1991 HMGR catalyzes the rate-limiting step in isoprenoid biosynthesis leading to accumulation of phytoalexins and steroid glycoalkaloids. Steroids 109-116 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 Solanum tuberosum 0-4 17322404-1 2007 Expression of the Drosophila orphan nuclear receptor DHR78 is regulated by the steroid hormone ecdysone and is required for growth and viability during larval stages. Steroids 79-94 Hormone-receptor-like in 78 Drosophila melanogaster 53-58 17123747-1 2007 The xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane receptor) and the vitamin D(3)-activated nuclear receptor VDR regulate steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, which mediate the efflux of water-soluble lipid metabolites from cells. Steroids 173-180 nuclear receptor subfamily 1, group I, member 2 Mus musculus 43-46 20547883-1 2010 Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands. Steroids 85-101 ferredoxin 1 Homo sapiens 37-41 1890991-0 1991 Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Steroids 86-102 estrogen receptor 1 Rattus norvegicus 14-31 17123747-1 2007 The xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane receptor) and the vitamin D(3)-activated nuclear receptor VDR regulate steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, which mediate the efflux of water-soluble lipid metabolites from cells. Steroids 173-180 nuclear receptor subfamily 1, group I, member 2 Mus musculus 48-67 17123747-1 2007 The xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane receptor) and the vitamin D(3)-activated nuclear receptor VDR regulate steroid and xenobiotic metabolism by inducing the phase I cytochrome P450 monooxygenases, phase II conjugating transferases, and the phase III transporters, which mediate the efflux of water-soluble lipid metabolites from cells. Steroids 173-180 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 160-163 20308029-2 2010 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway of estrogen detoxification in steroid target tissues, such as the prostate. Steroids 140-147 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 33-64 20308029-2 2010 Glucuronidation, mediated by the UDP-glucuronosyltransferase 1A1 (UGT1A1) enzyme, is a main metabolic pathway of estrogen detoxification in steroid target tissues, such as the prostate. Steroids 140-147 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 66-72 1890991-3 1991 Thus, hormonal regulation of ER gene expression in ARH and VMHvl neurons represents a direct mechanism by which circulating sex steroids could affect the responsiveness of these neurons to hormonal activation. Steroids 128-136 estrogen receptor 1 Rattus norvegicus 29-31 1849262-1 1991 The retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. Steroids 135-142 retinoic acid receptor alpha Homo sapiens 4-27 20392829-9 2010 However, GR alone appears involved in the sensitization of the cells to the chronotropic regulation through the cAMP pathway and in the hypertrophic response to steroids. Steroids 161-169 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 9-11 20238230-1 2010 Although most patients with idiopathic nephrotic syndrome (NS) respond to steroid treatment, development of steroid dependency may require a long-term multidrug therapy including steroid and calcineurin inhibitor. Steroids 108-115 calcineurin binding protein 1 Homo sapiens 191-212 17081691-0 2007 Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model. Steroids 0-7 immunoglobulin binding protein 1 Homo sapiens 43-49 17081691-1 2007 The alpha4 subunit of the GABA(A) receptor (GABAR) has relatively low expression in the CNS, but is increased in vivo following 48 h administration of the GABA-modulatory steroid 3alpha-OH-5alpha[beta]-pregnan-20-one (THP or [allo]pregnanolone) to female rats. Steroids 171-178 immunoglobulin binding protein 1 Homo sapiens 4-10 17081691-2 2007 The purpose of the following study was to determine the optimal conditions for steroid-induced upregulation of alpha4 expression in an in vitro model. Steroids 79-86 immunoglobulin binding protein 1 Homo sapiens 111-117 17081691-5 2007 Following neuronal differentiation in serum-free medium, 48 h THP treatment significantly increased alpha4 expression two-fold following application of nerve growth factor (NGF) suggesting that development of neuronal processes facilitates this effect of the steroid. Steroids 259-266 immunoglobulin binding protein 1 Homo sapiens 100-106 17081691-9 2007 These results suggest that both THP and E2 can increase expression of the GABAR alpha4 subunit, but that this effect is dependent upon the background steroid milieu as well as the degree of neuronal development. Steroids 150-157 immunoglobulin binding protein 1 Homo sapiens 80-86 17081691-10 2007 These findings demonstrate optimal conditions for steroid-induced upregulation of the alpha4 subunit in an in vitro system. Steroids 50-57 immunoglobulin binding protein 1 Homo sapiens 86-92 20238230-1 2010 Although most patients with idiopathic nephrotic syndrome (NS) respond to steroid treatment, development of steroid dependency may require a long-term multidrug therapy including steroid and calcineurin inhibitor. Steroids 108-115 calcineurin binding protein 1 Homo sapiens 191-212 1849262-1 1991 The retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. Steroids 135-142 retinoic acid receptor alpha Homo sapiens 29-32 20976089-6 2010 Sex steroids act probably by increasing the expression of RANKL by osteoblastic cells and alterations in the RANK/RANKL/OPG system in favor of osteoclasts. Steroids 4-12 TNF superfamily member 11 Homo sapiens 58-63 17302598-16 2007 CONCLUSION: Early steroid-withdrawal in renal transplant recipients with a sirolimus and CellCept-based calcineurin inhibitor-minimimization protocol can effectively reduce many of the steroid-related side effects, decrease risk factors for cardiovascular disease, and is associated with improved recipient survival without compromising graft function. Steroids 18-25 calcineurin binding protein 1 Homo sapiens 104-125 17302598-16 2007 CONCLUSION: Early steroid-withdrawal in renal transplant recipients with a sirolimus and CellCept-based calcineurin inhibitor-minimimization protocol can effectively reduce many of the steroid-related side effects, decrease risk factors for cardiovascular disease, and is associated with improved recipient survival without compromising graft function. Steroids 185-192 calcineurin binding protein 1 Homo sapiens 104-125 20976089-6 2010 Sex steroids act probably by increasing the expression of RANKL by osteoblastic cells and alterations in the RANK/RANKL/OPG system in favor of osteoclasts. Steroids 4-12 TNF superfamily member 11 Homo sapiens 114-119 20976089-6 2010 Sex steroids act probably by increasing the expression of RANKL by osteoblastic cells and alterations in the RANK/RANKL/OPG system in favor of osteoclasts. Steroids 4-12 basic transcription factor 3 pseudogene 11 Homo sapiens 120-123 17951166-7 2007 BMs from both steroid-naive and steroid-treated asthmatic patients showed significantly decreased expression of CD16, as compared to healthy subjects" BMs. Steroids 14-21 Fc gamma receptor IIIa Homo sapiens 112-116 1676210-1 1991 The hairless mouse has been used as a model to distinguish between local and systemic atrophogenic effects of topical steroids. Steroids 118-126 lysine demethylase and nuclear receptor corepressor Mus musculus 4-12 17951166-7 2007 BMs from both steroid-naive and steroid-treated asthmatic patients showed significantly decreased expression of CD16, as compared to healthy subjects" BMs. Steroids 32-39 Fc gamma receptor IIIa Homo sapiens 112-116 17951166-9 2007 Short-term administration of inhaled cortiocosteroids (ICS) in steroid-naive asthmatic patients led to significant reduction of CD16 expression and enhancement of CD14 expression. Steroids 45-52 Fc gamma receptor IIIa Homo sapiens 128-132 17330865-0 2007 Steroid pregnenolone sulfate enhances NMDA-receptor-independent long-term potentiation at hippocampal CA1 synapses: role for L-type calcium channels and sigma-receptors. Steroids 0-7 carbonic anhydrase 1 Homo sapiens 102-105 20363031-3 2010 In combat-related PTSD, the 18 kDa mitochondrial translocator protein (TSPO), essential for steroid synthesis, was found to be decreased. Steroids 92-99 translocator protein Homo sapiens 49-69 20363031-3 2010 In combat-related PTSD, the 18 kDa mitochondrial translocator protein (TSPO), essential for steroid synthesis, was found to be decreased. Steroids 92-99 translocator protein Homo sapiens 71-75 1824758-9 1991 Conversely, CSF-1 receptor expression was decreased in intermediate precursors treated with the steroid. Steroids 96-103 colony stimulating factor 1 receptor Mus musculus 12-26 20175769-1 2010 BACKGROUND: The calcineurin inhibitor tacrolimus and the anti-TNF-antibody infliximab are established options in steroid-refractory ulcerative colitis (UC). Steroids 113-120 calcineurin binding protein 1 Homo sapiens 16-37 20124410-1 2010 In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [35S]t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS1) and inhibition at higher concentrations (site NS2). Steroids 36-44 influenza virus NS1A binding protein Mus musculus 216-219 16973756-2 2007 In this study, we show that PXR plays an important endobiotic role in adrenal steroid homeostasis. Steroids 78-85 nuclear receptor subfamily 1, group I, member 2 Mus musculus 28-31 16973756-9 2007 We propose that PXR is a potential endocrine disrupting factor that may have broad implications in steroid homeostasis and drug-hormone interactions. Steroids 99-106 nuclear receptor subfamily 1, group I, member 2 Mus musculus 16-19 1986939-7 1991 These results suggest that gonadal steroids and PRL are involved, either directly or indirectly, in regulating the biosynthesis of LHRH in the rostral hypothalamus. Steroids 35-43 gonadotropin releasing hormone 1 Rattus norvegicus 131-135 17934251-1 2007 The ovarian steroid hormone, estradiol, is one of several peripheral metabolic signal modulators that are integrated at the level of the arcuate nucleus of the hypothalamus (ARH), and is implicated in the control of ARH neuropeptides that maintain energy balance, including neuropeptide Y (NPY) and proopiomelanocortin (POMC). Steroids 12-27 proopiomelanocortin Rattus norvegicus 299-318 17934251-1 2007 The ovarian steroid hormone, estradiol, is one of several peripheral metabolic signal modulators that are integrated at the level of the arcuate nucleus of the hypothalamus (ARH), and is implicated in the control of ARH neuropeptides that maintain energy balance, including neuropeptide Y (NPY) and proopiomelanocortin (POMC). Steroids 12-27 proopiomelanocortin Rattus norvegicus 320-324 17934251-2 2007 The present studies utilized quantitative real-time RT-PCR techniques to examine the hypothesis that estradiol regulates ARH NPY, POMC, and cocaine- and amphetamine-related transcript (CART) gene expression during acute insulin-induced hypoglycemia (IIH) and that adaptive modifications in transcriptional reactivity during recurring exposure are steroid dependent. Steroids 347-354 CART prepropeptide Rattus norvegicus 185-189 17065147-1 2006 Oocyte maturation is triggered by steroids in a transcription-independent fashion that involves an unusual positive feedback loop whereby MOS (a germ cell-specific Raf) activates MEK1, which in turn activates ERK2. Steroids 34-42 Raf-1 proto-oncogene, serine/threonine kinase S homeolog Xenopus laevis 164-167 20372840-9 2010 After irradiation and exposure to steroid and temozolomide 6 and 24 h later, a methylated MGMT promoter and negative protein expression were seen in U343 glioblastoma cell lines which have methylated promoter and negative protein expression. Steroids 34-41 O-6-methylguanine-DNA methyltransferase Homo sapiens 90-94 1659884-1 1991 Pyramidal neurons in the rat CA1 hippocampal area contain both mineralocorticoid (MR) and glucocorticoid receptors (GR) which bind the endogenous adrenal steroid corticosterone with differential affinity. Steroids 154-161 carbonic anhydrase 1 Rattus norvegicus 29-32 22009927-14 2010 CONCLUSION: Rifampicin may decrease the risk of steroid-induced ONFH by enhancing P-gp activity, thus preventing steroid-induced BMSC adipogenesis. Steroids 48-55 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 82-86 1745827-7 1991 Gonadal steroids exert positive feedback actions which also result in an increase in the amplitude of LHRH release, and this action may be exerted through a combination of cellular mechanisms which culminate in the production of a unique, punctuated set of synaptic signals. Steroids 8-16 gonadotropin releasing hormone 1 Rattus norvegicus 102-106 20852728-6 2010 We conclude from these studies that the miRNA biogenesis components Drosha, Dgcr8, Exportin-5 and Dicer1 are expressed in the mouse uterus and that Exportin-5 and Dicer1 appear to be the major steroid regulated components in the miRNA biogenesis pathway. Steroids 193-200 dicer 1, ribonuclease type III Mus musculus 163-169 17142748-6 2006 Finally, CD4(+) splenic T cells from Elocalcitol-treated NOD mice show decreased ability, upon adoptive transfer into NOD.SCID recipients, to induce autoimmune prostatitis, paralleled by a reduced capacity to produce IFN-gamma in response to prostate steroid-binding protein. Steroids 251-258 CD4 antigen Mus musculus 9-12 1803702-6 1991 Taking into consideration a high sensibility of oocytes to the EGF action, and also the fact that the character of changes of steroid hormones secreted by the ovary in culture under the action of EGF is the same as that under the influence of LH it is suggested that, the EGF and EGF-like proteins secreted by somatic follicle cells are the paracrinic regulators of the mammalian oocyte maturation which modulate neuroendocrine factors of the oogenesis control. Steroids 126-142 epidermal growth factor Homo sapiens 196-199 17034817-2 2006 Indeed, the other AKR enzymes that significantly reduce keto groups situated at position C17 of the steroid nucleus, the human type 3 3alpha-HSD (h3alpha-HSD3), the human and mouse type 5 17beta-HSD, and the rabbit 20alpha-HSD, produce only 17beta-hydroxy derivatives, although they possess more than 70% amino acid identity with m17alpha-HSD. Steroids 100-107 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 215-226 16835396-0 2006 Regulation of steroid hormone biosynthesis enzymes and organic anion transporters by forskolin and DHEA-S treatment in adrenocortical cells. Steroids 14-29 sulfotransferase family 2A member 1 Homo sapiens 99-105 16835396-4 2006 Additionally, we examined the impact of forskolin and DHEA-S on the expression of key enzymes in steroid biosynthesis and expression of hOAT3 and -4 in NCI-H295R cells. Steroids 97-104 sulfotransferase family 2A member 1 Homo sapiens 54-60 16835396-9 2006 We conclude that the increased cortisol release of adrenocortical cells by DHEA-S and forskolin stimulation is probably due to high expression of the key enzymes of steroid biosynthesis and hOAT3. Steroids 165-172 sulfotransferase family 2A member 1 Homo sapiens 75-81 20156558-2 2010 The steroid hormone 1alpha,25(OH)2-vitamin D3 (1,25(OH)2-D3) stimulates exocytosis in different cell systems by activating a nongenotropic vitamin D receptor (VDR). Steroids 4-19 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 139-157 20156558-2 2010 The steroid hormone 1alpha,25(OH)2-vitamin D3 (1,25(OH)2-D3) stimulates exocytosis in different cell systems by activating a nongenotropic vitamin D receptor (VDR). Steroids 4-19 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 159-162 20140739-2 2010 Conditional expression of this type III effector in a transgenic line carrying avrRpm1 under the control of a steroid-inducible promoter results in RPM1-dependent cell death that resembles the cell death response of the incompatible RPM1-avrRpm1 plant-bacterium interaction. Steroids 110-117 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 148-152 20140739-2 2010 Conditional expression of this type III effector in a transgenic line carrying avrRpm1 under the control of a steroid-inducible promoter results in RPM1-dependent cell death that resembles the cell death response of the incompatible RPM1-avrRpm1 plant-bacterium interaction. Steroids 110-117 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 233-237 1803702-6 1991 Taking into consideration a high sensibility of oocytes to the EGF action, and also the fact that the character of changes of steroid hormones secreted by the ovary in culture under the action of EGF is the same as that under the influence of LH it is suggested that, the EGF and EGF-like proteins secreted by somatic follicle cells are the paracrinic regulators of the mammalian oocyte maturation which modulate neuroendocrine factors of the oogenesis control. Steroids 126-142 epidermal growth factor Homo sapiens 196-199 1803702-6 1991 Taking into consideration a high sensibility of oocytes to the EGF action, and also the fact that the character of changes of steroid hormones secreted by the ovary in culture under the action of EGF is the same as that under the influence of LH it is suggested that, the EGF and EGF-like proteins secreted by somatic follicle cells are the paracrinic regulators of the mammalian oocyte maturation which modulate neuroendocrine factors of the oogenesis control. Steroids 126-142 epidermal growth factor Homo sapiens 196-199 1707631-5 1990 Northern blot hybridization on the endometrium of a pseudopregnant uterus revealed that the expression of endometrial M-CSF and c-fms mRNAs is regulated by synergistic action of female sex steroid hormones. Steroids 189-196 colony stimulating factor 1 Homo sapiens 118-123 17109497-9 2006 CONCLUSION: Oral steroid treatment in CC patients induced a simultaneous reduction of bowel movements and rectal release of ECP, bFGF, VEGF and albumin, suggesting that these polypeptides and increased mucosal permeability are important components of the pathophysiology in collagenous colitis. Steroids 17-24 ribonuclease A family member 3 Homo sapiens 124-127 2079728-5 1990 Serum levels of IgG3 in ALL and the Steroid group were as high as in normal controls. Steroids 36-43 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 16-20 16979821-2 2006 The peroxisome proliferator-activated receptor delta protein (PPARdelta), is a member of the steroid hormone super family of ligand-inducible transcription factors, and is of major relevance in lipid and cholesterol metabolism. Steroids 93-100 peroxisome proliferator activated receptor delta Homo sapiens 4-60 16979821-2 2006 The peroxisome proliferator-activated receptor delta protein (PPARdelta), is a member of the steroid hormone super family of ligand-inducible transcription factors, and is of major relevance in lipid and cholesterol metabolism. Steroids 93-100 peroxisome proliferator activated receptor delta Homo sapiens 62-71 20531483-0 2010 [Characteristics of steroid metabolism in transgenic Nicotiana tabacum plants bearing the CYP11A1 cDNA of cytochrome P450(SCC) from the bovine adrenal cortex]. Steroids 20-27 uncharacterized protein LOC107819388 Nicotiana tabacum 122-125 20531483-1 2010 In the mitochondria of animal steroidogenic tissues, cytochrome P450(SCC), encoded by the CYP11A1 gene, catalyzes the conversion of cholesterol into pregnenolone - the general precursor of all steroid hormones. Steroids 193-209 uncharacterized protein LOC107819388 Nicotiana tabacum 53-73 1963112-0 1990 Neurokinin A levels in the hypothalamus of rats and mice: effects of castration, gonadal steroids and expression of heterologous growth hormone genes. Steroids 89-97 tachykinin 1 Mus musculus 0-12 20531483-2 2010 In this work, we study the steroid metabolism in transgenic tobacco plants carrying the CYP11A1 cDNA cytochrome P450(SCC)from the bovine adrenal cortex. Steroids 27-34 uncharacterized protein LOC107819388 Nicotiana tabacum 117-120 20531483-6 2010 The results obtained indicate that the synthesis of an active P450(SCC) cytochrome in transgenic Nicotiana tabacum plants has a profound effect on steroid metabolism and is responsible for the specific phenotypic features of transgenic plants bearing CYP11A1 cDNA. Steroids 147-154 uncharacterized protein LOC107819388 Nicotiana tabacum 67-70 17083726-9 2006 High sputum IL-8 and IL-17A mRNA levels were also found in moderate-to-severe (persistent) asthmatics on inhaled steroid treatment. Steroids 113-120 interleukin 17A Homo sapiens 21-27 17086935-1 2006 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors. Steroids 181-188 vitamin D receptor Homo sapiens 124-142 1963112-10 1990 It is concluded that sex steroids may regulate the levels of neurokinin A in the hypothalamus of rats and mice. Steroids 25-33 tachykinin 1 Mus musculus 61-73 17086935-1 2006 1alpha,25-Dihydroxyvitamin D3 (1,25-(OH)2D3), the biologically active metabolite of vitamin D, mediates its actions via the vitamin D receptor (VDR), a member of the superfamily of steroid/thyroid hormone/retinoid receptors. Steroids 181-188 vitamin D receptor Homo sapiens 144-147 1978245-1 1990 The E74 gene is one of a small set of early genes induced by the steroid hormone ecdysone at the onset of metamorphosis in the fruit fly, Drosophila melanogaster. Steroids 65-80 Ecdysone-induced protein 74EF Drosophila melanogaster 4-7 16332426-11 2006 These results suggest that IL-4 and IL-6 are locally produced in the porcine CL, and that they inhibit steroid production from luteal cells via their specific receptors. Steroids 103-110 interleukin 4 Sus scrofa 27-31 19621276-6 2010 More specifically, blockage experiments with short interference RNA targeting HSP27 confirmed the role of this chaperone in the protective effect of the steroid. Steroids 153-160 heat shock protein 1 Mus musculus 78-83 20438664-5 2010 Ginsenosides with sugar moieties attached only to the C-3 position of the steroid-like structure, equivalent to the sugar position in cardiac glycosides, substantially inhibit Na+, K+-ATPase. Steroids 74-81 complement C3 Homo sapiens 54-57 17065400-0 2006 Regulation of adrenomedullin release from human endothelial cells by sex steroids and angiotensin-II. Steroids 73-81 adrenomedullin Homo sapiens 14-28 17065400-3 2006 We hypothesised that the sex steroids alter the percentage of vascular endothelial cells that secrete the vasodilator peptide, adrenomedullin and modify the adrenomedullin-stimulating action of angiotensin-II. Steroids 29-37 adrenomedullin Homo sapiens 127-141 17065400-3 2006 We hypothesised that the sex steroids alter the percentage of vascular endothelial cells that secrete the vasodilator peptide, adrenomedullin and modify the adrenomedullin-stimulating action of angiotensin-II. Steroids 29-37 adrenomedullin Homo sapiens 157-171 2290238-6 1990 Then she was treated with AT III concentrate and urokinase and her asthmatic symptom was significantly improved and steroid hormone could be easily reduced. Steroids 116-131 serpin family C member 1 Homo sapiens 26-32 16815476-5 2006 Here we demonstrate that LPA(3) expression is positively and negatively regulated by steroid hormones in mouse uteri. Steroids 85-101 lysophosphatidic acid receptor 3 Mus musculus 25-31 20142449-11 2010 Targeting steroid-resistant Th1 responses will be necessary to resolve chronic smoldering vasculitis. Steroids 10-17 negative elongation factor complex member C/D Homo sapiens 28-31 2209616-6 1990 When foetal hepatocytes were exposed to dexamethasone, an increase in ASL mRNA was detected, which was completely abolished by addition of actinomycin D, suggesting a transcriptional effect of the steroid. Steroids 197-204 argininosuccinate lyase Rattus norvegicus 70-73 20095590-1 2010 A general steroid synthesis is presented that relies on prior formation of three stereogenic centers (C8, C13, and C14) on a D ring template, followed by C- and B-ring cyclizations. Steroids 10-17 homeobox C13 Homo sapiens 106-109 16911685-0 2006 Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn"s disease: regulation by steroid treatment. Steroids 133-140 C-C motif chemokine ligand 5 Homo sapiens 13-19 16911685-0 2006 Secretion of RANTES (CCL5) and interleukin-10 from mesenteric adipose tissue and from creeping fat in Crohn"s disease: regulation by steroid treatment. Steroids 133-140 C-C motif chemokine ligand 5 Homo sapiens 21-25 16911685-9 2006 Crohn"s disease patients receiving steroids had a higher secretion rate of RANTES and IL-10. Steroids 35-43 C-C motif chemokine ligand 5 Homo sapiens 75-81 16911685-9 2006 Crohn"s disease patients receiving steroids had a higher secretion rate of RANTES and IL-10. Steroids 35-43 interleukin 10 Homo sapiens 86-91 2369744-2 1990 Ketoconazole, a potent but transient inhibitor of adrenal steroid hormone biosynthesis, inhibited IL-1 alpha induced increases in plasma corticosterone. Steroids 58-73 interleukin 1 alpha Mus musculus 98-108 16911685-11 2006 The elevated RANTES and IL-10 secretion from creeping fat in CD is not due to a CD-specific effect but caused by steroid treatment. Steroids 113-120 C-C motif chemokine ligand 5 Homo sapiens 13-19 16911685-11 2006 The elevated RANTES and IL-10 secretion from creeping fat in CD is not due to a CD-specific effect but caused by steroid treatment. Steroids 113-120 interleukin 10 Homo sapiens 24-29 16915001-7 2006 Hypothalamic KiSS-1 also functions as an essential integrator for peripheral inputs, including gonadal steroids and nutritional signals, controlling gonadotropin-releasing hormone and gonadotropin secretion. Steroids 103-111 KiSS-1 metastasis suppressor Homo sapiens 13-19 19915984-1 2010 Human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) catalyzes the reaction of estrone with NADPH to form estradiol and NADP(+), thereby regulating the biological activity of sex steroid hormones in a variety of tissues. Steroids 189-205 2,4-dienoyl-CoA reductase 1 Homo sapiens 102-107 19804449-11 2010 CONCLUSIONS: Our data suggest that reduced TH-2 type inflammation in DIA after inhaled steroid medication is reflected as elevated MMP-9 and MMP-9/TIMP-1 levels in BAL. Steroids 87-94 matrix metallopeptidase 9 Homo sapiens 131-136 19804449-11 2010 CONCLUSIONS: Our data suggest that reduced TH-2 type inflammation in DIA after inhaled steroid medication is reflected as elevated MMP-9 and MMP-9/TIMP-1 levels in BAL. Steroids 87-94 matrix metallopeptidase 9 Homo sapiens 141-146 2226349-14 1990 In the postnatal period, thyroid and steroid hormones including retinoic acid have been shown to modulate EGF and/or EGF receptors in several tissues. Steroids 37-53 epidermal growth factor Homo sapiens 106-109 20665260-1 2010 The mitochondrial membrane TranSlocator PrOtein (TSPO) is a 18-kDa transmembrane protein involved in various mitochondrial functions, among which the best characterised is cholesterol transport and steroid formation. Steroids 198-205 translocator protein Homo sapiens 27-47 20665260-1 2010 The mitochondrial membrane TranSlocator PrOtein (TSPO) is a 18-kDa transmembrane protein involved in various mitochondrial functions, among which the best characterised is cholesterol transport and steroid formation. Steroids 198-205 translocator protein Homo sapiens 49-53 16807499-5 2006 We have demonstrated that adenovirus-mediated forced expression of SF-1 in long-term cultured bone marrow cells can produce steroidogenic cells with the capacity for de novo synthesis of various steroid hormones in response to ACTH. Steroids 195-211 splicing factor 1 Homo sapiens 67-71 2226349-14 1990 In the postnatal period, thyroid and steroid hormones including retinoic acid have been shown to modulate EGF and/or EGF receptors in several tissues. Steroids 37-53 epidermal growth factor Homo sapiens 117-120 16700076-10 2006 Characterization of the NUDT16 gene identified putative steroid hormone response elements, which can now be investigated to understand its unique pattern of regulation in the earliest days of pregnancy. Steroids 56-71 U8 snoRNA-decapping enzyme Ovis aries 24-30 2171047-4 1990 The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney). Steroids 169-176 diazepam binding inhibitor Rattus norvegicus 67-70 19665520-5 2009 TSPO is mainly present in the mitochondrial outer membrane, where it promotes the translocation of cholesterol to the inner mitochondrial membrane, and, as demonstrated in other cellular systems, it allows the transformation of cholesterol into pregnenolone and the increase of steroid levels. Steroids 278-285 translocator protein Rattus norvegicus 0-4 19665520-6 2009 In the diabetic model of STZ rat, we have here assessed whether treatment with Ro5-4864 (i.e., a ligand of TSPO) could increase the low levels of neuroactive steroids in sciatic nerve and consequently to be protective in this experimental model. Steroids 158-166 translocator protein Rattus norvegicus 107-111 19665520-9 2009 In conclusion, data here reported show for the first time that a TSPO ligand, such as Ro5-4864, is effective in reducing the severity of diabetic neuropathy through a local increase of neuroactive steroid levels. Steroids 197-204 translocator protein Rattus norvegicus 65-69 19656632-6 2009 Progesterone, secreted by the ovaries, or produced de novo in the brain, is readily converted centrally to 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), and can influence SCEP, through rapid, non-classical steroid-mediated actions. Steroids 213-220 uromodulin Homo sapiens 154-157 16824587-0 2006 Role of brain neuroactive steroids in the functional interplay between the GABA(A) and the NPY-Y1 receptor mediated signals in the amygdala. Steroids 26-34 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 75-82 16824587-4 2006 These data provide evidence that neuroactive steroids may play an important role in the functional interaction between the GABA(A) receptor and NPY-Y(1)R mediated pathways in the amygdala, which might represent an important regulatory mechanism for modulation of several functions, including ethanol withdrawal. Steroids 45-53 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 123-130 16824587-4 2006 These data provide evidence that neuroactive steroids may play an important role in the functional interaction between the GABA(A) receptor and NPY-Y(1)R mediated pathways in the amygdala, which might represent an important regulatory mechanism for modulation of several functions, including ethanol withdrawal. Steroids 45-53 neuropeptide Y receptor Y1 Mus musculus 148-153 2171047-4 1990 The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney). Steroids 169-176 diazepam binding inhibitor Rattus norvegicus 141-144 16564554-12 2006 Reduced expression of both synaptopodin and GLEPP1 is associated with poor response to steroid therapy in primary FSGS. Steroids 87-94 protein tyrosine phosphatase receptor type O Homo sapiens 44-50 2171047-4 1990 The immunohistochemical analysis revealed discrete localization of DBI-LI in cell types with specialized functions: for example, the highest DBI-LI content was found in steroid-producing cells (glomerulosa and fasciculata cells of adrenal cortex, Leydig cells of testis); lower DBI-LI immunostaining was found in epithelial cells specialized for water and electrolyte transport (intestinal mucosa, distal convoluted tubules of kidney). Steroids 169-176 diazepam binding inhibitor Rattus norvegicus 141-144 1690638-2 1990 Both the so-called GH-dependent (IGF-BP3) and non-GH-dependent (IGF-BP2) proteins dose dependently inhibited granulosa cell estradiol and progesterone production with IC50s of 4.1-7.6 nM for IGF-BP3 and 12.6-12.9 nM for IGF-BP2, the actual value depending upon the steroid being measured. Steroids 265-272 insulin-like growth factor binding protein 3 Rattus norvegicus 33-40 16574160-8 2006 This study demonstrates that the mechanism by which ovarian steroid biosynthesis is altered during acute nephrosis involves damage at the P450scc and StAR mRNA synthesis and processing. Steroids 60-67 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 138-145 16504331-2 2006 The enzyme can be supported in its activity with adrenodoxin (Adx) and adrenodoxin reductase (AdR) from bovine adrenals, supplying this enzyme with the reducing equivalents necessary for steroid hydroxylation activity. Steroids 187-194 ferredoxin reductase Bos taurus 71-92 2351706-5 1990 Hitherto, PP14 has been believed to be an endometrial protein arising from the decidua during pregnancy, under the influence of ovarian steroids. Steroids 136-144 progestagen associated endometrial protein Homo sapiens 10-14 16504331-2 2006 The enzyme can be supported in its activity with adrenodoxin (Adx) and adrenodoxin reductase (AdR) from bovine adrenals, supplying this enzyme with the reducing equivalents necessary for steroid hydroxylation activity. Steroids 187-194 ferredoxin reductase Bos taurus 94-97 19748597-10 2009 Neither P4 nor P5 affected expression of the studied genes; however, both steroids diminished (P<0.05) OT-stimulated mRNA expression of COX2. Steroids 74-82 prostaglandin-endoperoxide synthase 2 Bos taurus 139-143 19748597-11 2009 The data suggest that: (a) myometrial cells are able to synthesize both PGF2alpha and PGE and (b) synthesis of these PGs may be regulated by steroids through a transcription-independent manner, which modulated the effect of OT on COX2 mRNA expression. Steroids 141-149 prostaglandin-endoperoxide synthase 2 Bos taurus 230-234 16493179-1 2006 Our previous research has identified the granulin (grn) and p130 genes as sex steroid-regulated genes in the neonatal rat hypothalamus that might be involved in sexual differentiation of the brain. Steroids 78-85 granulin precursor Rattus norvegicus 41-49 2139106-8 1990 Steroid hormones, known transcriptional enhancers and repressors of specific cellular genes, were implicated in the controlling mechanisms over TCGF production. Steroids 0-16 interleukin 2 Mus musculus 144-148 16493179-1 2006 Our previous research has identified the granulin (grn) and p130 genes as sex steroid-regulated genes in the neonatal rat hypothalamus that might be involved in sexual differentiation of the brain. Steroids 78-85 granulin precursor Rattus norvegicus 51-54 16483721-7 2006 Given the steroid-sensitive nature of nNOS functions and the multiple roles nitric oxide plays in the MPOA, we propose that nitric oxide provides important integration of various neurochemical and neuroendocrine signals. Steroids 10-17 nitric oxide synthase 1 Rattus norvegicus 38-42 16216300-6 2006 Genes coding for enzymes involved in the later or final steps of steroid production (CYP11B1, CYP11B2, CYP19, 3beta-HSD1, 3beta-HSD2 and 17beta-HSD1) were up-regulated to various extents by most PCBs. Steroids 65-72 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 85-92 19595697-1 2009 The steroid dehydroepiandrosterone sulfate (DHEA-S) is associated with longevity and adaptation against external stress in humans. Steroids 4-11 sulfotransferase family 2A member 1 Homo sapiens 44-50 2139106-11 1990 This steroid influence resulted in an enhanced potential for IL-2 secretion after activation. Steroids 5-12 interleukin 2 Mus musculus 61-65 2329377-4 1990 Removal of circulating gonadal steroids by ovariectomy of adult female rats resulted in a profound decrease in dendritic spine density in CA1 pyramidal cells of the hippocampus. Steroids 31-39 carbonic anhydrase 1 Rattus norvegicus 138-141 19790047-1 2009 OBJECTIVE: To examine the features of the intraosseous vasculature, the size of the marrow stem cell pool (MSCP), and expression of vascular endothelial growth factor A (VEGF) during inadequate repair of steroid-associated osteonecrotic lesions in rabbits. Steroids 204-211 vascular endothelial growth factor A Oryctolagus cuniculus 132-168 19790047-1 2009 OBJECTIVE: To examine the features of the intraosseous vasculature, the size of the marrow stem cell pool (MSCP), and expression of vascular endothelial growth factor A (VEGF) during inadequate repair of steroid-associated osteonecrotic lesions in rabbits. Steroids 204-211 vascular endothelial growth factor A Oryctolagus cuniculus 170-174 16691503-1 2006 Expression of peripheral benzodiazepine receptors (PBR) has been found in every tissue examined; however, it is most abundant in steroid-producing tissues. Steroids 129-136 translocator protein Rattus norvegicus 14-49 16691503-1 2006 Expression of peripheral benzodiazepine receptors (PBR) has been found in every tissue examined; however, it is most abundant in steroid-producing tissues. Steroids 129-136 translocator protein Rattus norvegicus 51-54 2329377-7 1990 These results demonstrate that gonadal steroids are necessary for the maintenance of normal adult CA1 hippocampal pyramidal cell structure. Steroids 39-47 carbonic anhydrase 1 Rattus norvegicus 98-101 19485886-2 2009 This review concentrates on GLUT transporter expression in both normal and cancerous classical sex-steroid hormone tissues (i.e. breast, uterus, ovary, testis and prostate, among others). Steroids 99-114 solute carrier family 2 member 1 Homo sapiens 28-32 2311190-1 1990 O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic clearance of these steroids. Steroids 143-151 catechol-O-methyltransferase Rattus norvegicus 48-76 16718630-8 2006 Accordingly, using multivariate regression analyses, the best steroid predictor of progesterone level was plasma DHEA-S. Steroids 62-69 sulfotransferase family 2A member 1 Homo sapiens 113-119 16718630-11 2006 Circulating DHEA-S level was the best steroid correlate of plasma progesterone. Steroids 38-45 sulfotransferase family 2A member 1 Homo sapiens 12-18 2338011-4 1990 By contrast the administration of GP-C (RUMALON) to dexamethasone-treated animals reduced these steroid effects. Steroids 96-103 glycophorin C Rattus norvegicus 34-38 16614385-0 2006 The influence of sex steroid hormones on ferrochelatase gene expression in Harderian gland of hamster (Mesocricetus auratus). Steroids 21-37 ferrochelatase Homo sapiens 41-55 19627466-2 2009 Together with its sulfate version, DHEA-sulfate (DHEAS), it is the most abundant steroid in humans. Steroids 81-88 sulfotransferase family 2A member 1 Homo sapiens 49-54 2342476-7 1990 The difference of four amino acids in the steroid binding domain of hARb is associated with altered DHT binding and thus a lack of trans-activation by way of AR responsive elements in MMTV-long terminal repeat. Steroids 42-49 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 69-71 19502420-5 2009 Ex vivo effects of insulin, metformin, and steroid hormones on adipose tissue chemerin protein production and secretion into conditioned media were assessed by Western blotting and enzyme-linked immunosorbent assay, respectively. Steroids 43-59 retinoic acid receptor responder 2 Homo sapiens 78-86 16595698-5 2006 A steroid response unit at position -146/-119 within the mouse Ahsg promoter mediates the glucocorticoid-induced increase of Ahsg mRNA. Steroids 2-9 alpha-2-HS-glycoprotein Mus musculus 63-67 16595698-5 2006 A steroid response unit at position -146/-119 within the mouse Ahsg promoter mediates the glucocorticoid-induced increase of Ahsg mRNA. Steroids 2-9 alpha-2-HS-glycoprotein Mus musculus 125-129 2306143-7 1990 Patients with two or more HLA-A or HLA-B matches had a reduced number of rejection episodes (3/10 versus 19/34) and a lower incidence of steroid-resistant rejection (1/10 versus 18/34; p = 0.01). Steroids 137-144 major histocompatibility complex, class I, B Homo sapiens 35-40 16357103-1 2006 The vitamin D receptor (VDR) regulates steroid and drug metabolism by inducing the genes encoding phase I and phase II enzymes. Steroids 39-46 vitamin D receptor Homo sapiens 4-22 16357103-1 2006 The vitamin D receptor (VDR) regulates steroid and drug metabolism by inducing the genes encoding phase I and phase II enzymes. Steroids 39-46 vitamin D receptor Homo sapiens 24-27 16357103-2 2006 SULT2A1 is a liver- and intestine-expressed sulfo-conjugating enzyme that converts the alcohol-OH of neutral steroids, bile acids, and drugs to water-soluble sulfated metabolites. Steroids 109-117 sulfotransferase family 2A member 1 Homo sapiens 0-7 19477906-1 2009 The cytochrome P450scc (cholesterol side-chain cleavage enzyme) encoded by CYP11A1 catalyzes the first step in steroidogenesis by converting cholesterol to pregnenolone, and thus, controls the synthesis rate of steroid hormones. Steroids 211-227 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 75-82 2328938-2 1990 The CYP21B gene encodes an adrenal microsomal cytochrome P-450, which is specific for steroid 21-hydroxylation (P450c21). Steroids 86-93 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 4-10 19740260-9 2009 Significant results in univariate and multivariate analysis of the association between biomarkers and BODE components were: serum MCP-1 correlated with FEV(1)% and 6MWD; serum IL-8 and GRO-alpha correlated with steroid use; serum TNF-alpha correlated with steroid use and FEV(1)%; and serum MMP-9 correlated with MMRC dyspnoea scale. Steroids 211-218 C-X-C motif chemokine ligand 1 Homo sapiens 185-194 16427152-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR). Steroids 15-30 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-122 16427152-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear Vitamin D receptor (VDR). Steroids 15-30 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 124-127 2118951-1 1990 Interferon-gamma (IFN-gamma) was used to treat rats with steroid-induced Pneumocystis carinii pneumonia (PCP). Steroids 57-64 interferon gamma Rattus norvegicus 0-16 2332422-7 1990 A similar sequence was also found in the 5"-flanking regions of all genes for the steroid hydroxylating cytochromes P-450: P-450(SCC), P-450(11 beta), P-450(17 alpha), and P-450(C21), in the adrenal cortex. Steroids 82-89 steroid 21-hydroxylase Bos taurus 172-181 16595713-4 2006 Sex steroids regulate the expression of KiSS-1 mRNA in the brain through direct action on KiSS-1 neurons. Steroids 4-12 KiSS-1 metastasis suppressor Homo sapiens 40-46 16595713-4 2006 Sex steroids regulate the expression of KiSS-1 mRNA in the brain through direct action on KiSS-1 neurons. Steroids 4-12 KiSS-1 metastasis suppressor Homo sapiens 90-96 16595713-5 2006 In the arcuate nucleus (Arc), sex steroids inhibit the expression of KiSS-1, suggesting that these neurons serve as a conduit for the negative feedback regulation of gonadotropin secretion. Steroids 34-42 KiSS-1 metastasis suppressor Homo sapiens 69-75 16595713-6 2006 In the anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of KiSS-1, implying that KiSS-1 neurons in this region may have a role in the preovulatory LH surge (in the female) or sexual behavior (in the male). Steroids 57-65 KiSS-1 metastasis suppressor Homo sapiens 91-97 16595713-6 2006 In the anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of KiSS-1, implying that KiSS-1 neurons in this region may have a role in the preovulatory LH surge (in the female) or sexual behavior (in the male). Steroids 57-65 KiSS-1 metastasis suppressor Homo sapiens 113-119 2243540-0 1990 Differential effects of sex steroids on uterine and renal ODC activity in ovariectomized rats. Steroids 28-36 ornithine decarboxylase 1 Rattus norvegicus 58-61 16373418-5 2006 Both estradiol and testosterone regulate the expression of the Kiss1 gene in the Arc and AVPV; however, the response of the Kiss1 gene to these steroids is exactly opposite between these two nuclei. Steroids 144-152 KiSS-1 metastasis suppressor Homo sapiens 63-68 16373418-5 2006 Both estradiol and testosterone regulate the expression of the Kiss1 gene in the Arc and AVPV; however, the response of the Kiss1 gene to these steroids is exactly opposite between these two nuclei. Steroids 144-152 KiSS-1 metastasis suppressor Homo sapiens 124-129 16215981-0 2006 MAP kinases p38 and JNK are activated by the steroid hormone 1alpha,25(OH)2-vitamin D3 in the C2C12 muscle cell line. Steroids 45-60 mitogen-activated protein kinase 8 Mus musculus 20-23 2326240-4 1990 Among xenobiotic and steroid metabolizing activities, only CSCC and AHH showed a significant negative correlation. Steroids 21-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-71 16430309-17 2006 CYP3A7 has a specific role in hydroxylation of retinoic acid and 16alpha-hydroxylation of steroids, and is therefore of relevance both to normal development and carcinogenesis.CYP3A43 is the most recently discovered CYP3A isoform. Steroids 90-98 cytochrome P450 family 3 subfamily A member 43 Homo sapiens 176-183 16384973-7 2006 IL-10 was higher in the panuveitis group on steroids (P < 0.01). Steroids 44-52 interleukin 10 Homo sapiens 0-5 33590597-7 2021 The functional annotation of DEmiRNA-target DEmRNAs revealed that C-type lectin receptor signaling pathway, Steroid biosynthesis and Galactose metabolism were significantly enriched KEGG pathways. Steroids 108-115 C-type lectin domain family 4 member D Homo sapiens 66-88 16384973-12 2006 The increased IL-10 in the steroid treated group suggests glucocorticoid-induced IL-10 upregulation. Steroids 27-34 interleukin 10 Homo sapiens 14-19 16384973-12 2006 The increased IL-10 in the steroid treated group suggests glucocorticoid-induced IL-10 upregulation. Steroids 27-34 interleukin 10 Homo sapiens 81-86 16632873-3 2006 P450scc is the key enzyme catalyzing the conversion of cholesterol (CHOL) into PREG, the rate-limiting step in the biosynthesis of all classes of steroids. Steroids 146-154 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 0-7 16632875-3 2006 New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. Steroids 161-168 neuritin 1 Mus musculus 88-96 16632875-3 2006 New work on two relevant motoneuron proteins, the survival of motor neuron protein, and neuritin or candidate plasticity-related gene 15, indicates differential steroid regulation of these two proteins after axotomy. Steroids 161-168 neuritin 1 Mus musculus 100-136 33767353-1 2021 Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. Steroids 0-7 nuclear receptor coactivator 3 Homo sapiens 32-37 16109736-2 2006 Within the adrenal cortex, ACTH-dependent transcriptional responses, including transcriptional activation of several key steroidogenic enzymes within the steroid biosynthetic pathway, are largely dependent upon SF-1 action. Steroids 121-128 splicing factor 1 Homo sapiens 211-215 33767353-1 2021 Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. Steroids 0-7 nuclear receptor coactivator 3 Homo sapiens 38-43 16338086-1 2006 The peripheral-type benzodiazepine receptor is a mitochondrial protein expressed at high levels in steroid synthesizing tissues, including the glial cells of the brain. Steroids 99-106 translocator protein Homo sapiens 4-43 33767353-1 2021 Steroid receptor coactivator 3 (SRC-3/NCoA3/AIB1), is a key regulator of gene transcription and it plays a central role in breast cancer (BC) tumorigenesis, making it a potential therapeutic target. Steroids 0-7 nuclear receptor coactivator 3 Homo sapiens 44-48 16338086-5 2006 Upon ligand activation peripheral-type benzodiazepine receptor-dependent cholesterol transport into mitochondria is accelerated leading in increased formation of neuroactive steroids. Steroids 174-182 translocator protein Homo sapiens 23-62 33232676-2 2020 By whole-exome sequencing (WES), we here discovered bi-allelic variants in the formin DAAM2 in four unrelated families with steroid-resistant NS. Steroids 124-131 dishevelled associated activator of morphogenesis 2 Homo sapiens 86-91 16338086-7 2006 Thus, peripheral-type benzodiazepine receptor drug ligand-induced neuroactive steroid formation offers a means to regulate brain dysfunction. Steroids 78-85 translocator protein Homo sapiens 6-45 33233866-5 2020 Conventional and recently developed agents for treating AD such as steroid, calcineurin inhibitors, cyclosporine, dupilumab, and JAK inhibitors inhibit the IL-13/IL-4-JAK-STAT6/STAT3 axis, while older remedies such as coal tar and glyteer are antioxidative AHR agonists. Steroids 67-74 signal transducer and activator of transcription 6 Homo sapiens 171-176 17065978-4 2006 It is hypothesized, that in women, the use of female sex steroids leads to a downregulation of 5-HT2C receptors that contributes to atypical depressive symptoms and premenstrual dysphoria. Steroids 57-65 5-hydroxytryptamine receptor 2C Homo sapiens 95-101 33235808-5 2020 We report the case of a patient treated with nivolumab (an anti-PD-L1 antibody) for a stage IV resected melanoma who developed recurrence of steroid-refractory liver toxicity that was later discovered to be associated with acute exacerbation of chronic undiagnosed hepatitis B. Steroids 141-148 CD274 molecule Homo sapiens 64-69 16888409-7 2006 We suggest that expression of TADG-14/KLK8may be regulated by sex steroid hormones in endometria. Steroids 66-82 kallikrein related peptidase 8 Homo sapiens 30-37 16888409-7 2006 We suggest that expression of TADG-14/KLK8may be regulated by sex steroid hormones in endometria. Steroids 66-82 kallikrein related peptidase 8 Homo sapiens 38-42 29914889-9 2018 Accordingly, steroid efficacy to transactivate MKP-1 and GILZ and to downregulate p-p38, p-GATA-3 as well as proinflammatory cytokine levels was also seen after two but not four provocations. Steroids 13-20 GATA binding protein 3 Mus musculus 91-97 16325168-1 2005 The steroid hormone 20-hydroxyecdysone (ecdysone) activates a relatively small number of immediate-early genes during Drosophila pupal development, yet is able to orchestrate distinct differentiation events in a wide variety of tissues. Steroids 4-19 Partner of Bursicon Drosophila melanogaster 129-134 29914889-10 2018 In conclusion, we report that repeated allergen exposure causes GC-insensitive asthma in A/J mice in a mechanism associated with decrease in GCR availability and subsequent loss of steroid capacity to modulate pivotal regulatory proteins, such as GATA-3, p-p38, MKP-1, and GILZ. Steroids 181-188 GATA binding protein 3 Mus musculus 247-253 16388839-1 2005 The peripheral benzodiazepine receptors (PBR) might be involved in certain pathophysiological events, such as anxiety, by stimulating the production of neuroactive steroids in the brain. Steroids 164-172 translocator protein Rattus norvegicus 4-39 16388839-1 2005 The peripheral benzodiazepine receptors (PBR) might be involved in certain pathophysiological events, such as anxiety, by stimulating the production of neuroactive steroids in the brain. Steroids 164-172 translocator protein Rattus norvegicus 41-44 34959084-7 2022 Taken together, we found that both porcine miR-20b and miR-31 target HSD17B14 gene, but miR-31 also targets FSHR gene to regulate the metabolism of steroid hormones and the apoptosis of porcine ovarian GCs. Steroids 148-155 microRNA 31 Homo sapiens 55-61 34959084-7 2022 Taken together, we found that both porcine miR-20b and miR-31 target HSD17B14 gene, but miR-31 also targets FSHR gene to regulate the metabolism of steroid hormones and the apoptosis of porcine ovarian GCs. Steroids 148-155 microRNA 31 Homo sapiens 88-94 34875337-0 2022 Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line. Steroids 138-145 phosphodiesterase 5A, cGMP-specific Mus musculus 0-25 16091484-9 2005 Steroid conversion patterns indicated a particularly increased activity of 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD5) in the older men, demonstrated by significantly higher conversion rates of DHEA to androstenediol and of androstenedione to testosterone (all P < 0.05). Steroids 0-7 RNA, U1 small nuclear 4 Homo sapiens 75-130 34971621-3 2022 Aims of this study were: 1) to develop a murine model of steroid-resistant asthma, 2) to elucidate that predominant cellular source of a type-2 cytokine, IL-5 was group 2 innate lymphoid cells (ILC2s), 3) to analyze pathogenic alteration of ILC2s in the severe asthma, and 4) to evaluate therapeutic potential of anti-IL-5 monoclonal antibody (mAb) on the steroid-resistant asthma. Steroids 57-64 interleukin 5 Mus musculus 154-158 16079298-4 2005 When expressed in Xenopus laevis oocytes, rOat5 mediated the transport of sulfate conjugates of steroids such as estrone-3-sulfate (E(1)S; K(m) = 18.9 +/- 3.9 microM) and dehydroepiandrosterone sulfate (K(m) = 2.3 +/- 0.2 microM) in a sodium-independent manner, in addition to OTA. Steroids 96-104 solute carrier family 22, member 24 Rattus norvegicus 42-47 34971621-3 2022 Aims of this study were: 1) to develop a murine model of steroid-resistant asthma, 2) to elucidate that predominant cellular source of a type-2 cytokine, IL-5 was group 2 innate lymphoid cells (ILC2s), 3) to analyze pathogenic alteration of ILC2s in the severe asthma, and 4) to evaluate therapeutic potential of anti-IL-5 monoclonal antibody (mAb) on the steroid-resistant asthma. Steroids 57-64 interleukin 5 Mus musculus 318-322 16341769-3 2005 Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone. Steroids 98-106 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 0-19 16341769-3 2005 Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone. Steroids 98-106 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 21-26 34971621-3 2022 Aims of this study were: 1) to develop a murine model of steroid-resistant asthma, 2) to elucidate that predominant cellular source of a type-2 cytokine, IL-5 was group 2 innate lymphoid cells (ILC2s), 3) to analyze pathogenic alteration of ILC2s in the severe asthma, and 4) to evaluate therapeutic potential of anti-IL-5 monoclonal antibody (mAb) on the steroid-resistant asthma. Steroids 356-363 interleukin 5 Mus musculus 154-158 16341769-3 2005 Cytochrome P450-c17 (CYP17) interacts with cytochrome b5 in the biosynthesis of the 16-androstene steroids and the sex steroids from pregnenolone. Steroids 98-106 cytochrome b5 type A Sus scrofa 43-56 16341769-4 2005 Amino acid substitutions in CYP17 could therefore affect the ability of this enzyme to catalyze the reactions leading to the production of androstenone and the sex steroids. Steroids 164-172 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 28-33 34971621-6 2022 ILC2s isolated from the lung of the steroid-insensitive model (500-mug OVA) produced significantly larger amounts of IL-5 in response to IL-33/TSLP than ILC2s from the steroid-sensitive model (5-mug OVA). Steroids 36-43 interleukin 5 Mus musculus 117-121 34967072-7 2022 G-CSF use was associated with transplant center, induction immunosuppression, steroid-free maintenance immunosuppression, hospitalization, and decreases in mycophenolate mofetil, valganciclovir, and trimethoprim-sulfamethoxazole dosing. Steroids 78-85 colony stimulating factor 3 Homo sapiens 0-5 16178883-10 2005 CONCLUSIONS: In rat, liver transport proteins of the Oatp and Mrp family are expressed and regulated in a gender-specific manner according to sexual differences in the hepatic metabolism of steroids and drugs. Steroids 190-198 ATP binding cassette subfamily C member 2 Rattus norvegicus 62-65 34929619-5 2022 Interestingly, genes upregulated by the globular form of adiponectin (gACRP30) were associated to steroid hormones biosynthesis, whereas resistin had no effect on the transcriptome of MA-10 Leydig cells. Steroids 98-105 adiponectin, C1Q and collagen domain containing Mus musculus 57-68 16417097-1 2005 OBJECTIVES: The efficacy of antenatal steroid therapy (ANS--use with the recommendation from 1999; therapy repeated every 7-10 days; dexamethasone was used) on the incidence of RDS in neonates born before 34 weeks of gestation has been well documented in several studies. Steroids 38-45 peripherin 2 Homo sapiens 177-180 34848449-2 2021 This study evaluated the effects of steroid-based compounds on copper uptake and proliferation of prostate cancer cells based on their anticancer activity and previous docking analysis of steroid-based copper transporter 1 inhibitors. Steroids 188-195 solute carrier family 31 member 1 Homo sapiens 202-222 16227953-3 2005 AIM: The aim of this paper was to study the distribution of CD8+ subsets, of soluble receptors of CD8 and IL-2 during a steroid treatment with prednisone and deflazacort. Steroids 120-127 CD8a molecule Homo sapiens 60-63 16254005-6 2005 We conclude that ovarian steroids, TNF-alpha and TGF-beta act as key regulators of endometrial IL-13 and IL-15 expression which act locally regulating TNFR expression in a cell-specific manner. Steroids 25-33 interleukin 15 Homo sapiens 105-110 34848449-8 2021 Steroid-based copper transporter 1 inhibitors may become novel anticancer drugs for targeted anti-copper therapy of prostate cancer and other copper hypermetabolic cancers. Steroids 0-7 solute carrier family 31 member 1 Homo sapiens 14-34 16320598-0 2005 [Pax2 expression in children with steroid-resistant primary nephrotic syndrome]. Steroids 34-41 paired box 2 Homo sapiens 1-5 34273001-19 2021 Steroid treatment has been successfully used in severe GI manifestations; however, our data do not support its association with low relapse risk. Steroids 0-7 G protein subunit alpha i1 Homo sapiens 55-57 15975799-3 2005 In addition, a subset of the novel compounds showing high affinity for PBR was tested for their ability to modulate the steroid biosynthesis in C6 glioma cells. Steroids 120-127 translocator protein Homo sapiens 71-74 34273001-21 2021 Steroid treatment should be used when GI manifestations are severe. Steroids 0-7 G protein subunit alpha i1 Homo sapiens 38-40 34628357-5 2021 While bromosulfophthalein and atorvastatin were substrates of both transporters, the steroid sulfate conjugates estrone 3-sulfate (E1S), progesterone sulfate and dehydroepiandrosterone sulfate were only transported by hOATP2B1. Steroids 85-92 solute carrier organic anion transporter family member 2B1 Homo sapiens 218-226 15901914-11 2005 These data indicate that hepatic steroid- and xenobiotic-metabolizing enzymes are susceptible to DBP induction at the fetal stage; such effects on enzyme expression are likely mediated by xenobiotic-responsive transcriptional factors, including CAR and PXR. Steroids 33-40 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 245-248 16002301-5 2005 Kiss1 mRNA is differentially regulated by sex steroids in distinct hypothalamic nuclei. Steroids 46-54 KiSS-1 metastasis suppressor Homo sapiens 0-5 34628357-10 2021 Taken together, we report that OATP2B1 exhibited differences in recognition of steroid sulfate conjugates comparing the rat and human orthologues. Steroids 79-86 solute carrier organic anion transporter family member 2B1 Homo sapiens 31-38 34866263-1 2021 Androgens are steroid hormones that play a critical role in brain development and sexual maturation by acting upon both androgen receptors (AR) and estrogen receptors (ERalpha/beta) after aromatization. Steroids 14-21 estrogen receptor 1 (alpha) Mus musculus 168-180 15728796-9 2005 In serially sectioned ovaries from unstimulated rats as well as from eCG-treated rats, expression of heparanase was noted exclusively in the ovarian steroid-producing interstitial tissue. Steroids 149-156 heparanase Rattus norvegicus 101-111 15831567-0 2005 Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Steroids 57-65 KiSS-1 metastasis-suppressor Mus musculus 27-33 34847852-1 2021 Progesterone receptor membrane component 1 (PGRMC1) is a trans-membrane evolutionarily conserved protein with a cytochrome b5 like heme/steroid binding domain. Steroids 136-143 progesterone receptor membrane component 1 Homo sapiens 0-42 15950612-11 2005 Androgen receptor-positive Leydig, Sertoli, and some peritubular myoepithelial cells express SUMO-1, findings suggesting a role in modulating steroid action. Steroids 142-149 androgen receptor Rattus norvegicus 0-17 15950612-11 2005 Androgen receptor-positive Leydig, Sertoli, and some peritubular myoepithelial cells express SUMO-1, findings suggesting a role in modulating steroid action. Steroids 142-149 small ubiquitin-like modifier 1 Rattus norvegicus 93-99 34847852-1 2021 Progesterone receptor membrane component 1 (PGRMC1) is a trans-membrane evolutionarily conserved protein with a cytochrome b5 like heme/steroid binding domain. Steroids 136-143 progesterone receptor membrane component 1 Homo sapiens 44-50 34847852-1 2021 Progesterone receptor membrane component 1 (PGRMC1) is a trans-membrane evolutionarily conserved protein with a cytochrome b5 like heme/steroid binding domain. Steroids 136-143 cytochrome b5 type A Homo sapiens 112-125 15755854-1 2005 Dehydroepiandrosterone (DHEA) sulfate (DHEAS) is the most abundant steroid in the human circulation and is thought to be the circulating hydrophilic storage form of DHEA. Steroids 67-74 sulfotransferase family 2A member 1 Homo sapiens 39-44 15755854-2 2005 It is generally accepted that DHEA and DHEAS inter-convert freely and continuously via hydroxysteroid sulfotransferases and steroid sulfatase and that only desulfated DHEA can be converted downstream to sex steroids. Steroids 207-215 sulfotransferase family 2A member 1 Homo sapiens 39-44 34847852-3 2021 PGRMC1 has been reported to possess pleiotropic functions, such as participating in cellular and membrane trafficking, steroid hormone signaling, cholesterol metabolism and steroidogenesis, glycolysis and mitochondrial energy metabolism, heme transport and homeostasis, neuronal movement and synaptic function, autophagy, anti-apoptosis, stem cell survival and the list is still expanding. Steroids 119-126 progesterone receptor membrane component 1 Homo sapiens 0-6 34787076-3 2021 Furthermore, gonadal steroids regulate GnRH pulsatile dynamics across the ovarian cycle by altering KNDy neurons" signalling properties. Steroids 21-29 gonadotropin releasing hormone 1 Mus musculus 39-43 15933496-2 2005 However, the most sensitive electrophysiological parameters at follow-up, and most effective type of different methods of steroid treatment for CTS, remain unknown. Steroids 122-129 transthyretin Homo sapiens 144-147 15933496-9 2005 These findings show that steroid injection is superior to iontophoresis and phonophoresis in the treatment of CTS, and that the most sensitive neurophysiologic parameters in follow-up are D4M-D4U and D2M-D5U, being the objective measures of the outcome of CTS treatment. Steroids 25-32 transthyretin Homo sapiens 110-113 34787076-11 2021 Therefore, we anticipate our model to be a cornerstone for a more quantitative understanding of the pathways via which gonadal steroids regulate GnRH pulse generator dynamics. Steroids 127-135 gonadotropin releasing hormone 1 Mus musculus 145-149 34656442-12 2022 CONCLUSIONS: Sputum MUC5AC is increased by protein levels and involved in airway type 2/eosinophilic inflammation and airway hyperresponsiveness in steroid-untreated patients with mild asthma. Steroids 148-155 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 20-26 15862534-0 2005 Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity. Steroids 43-50 nitric oxide synthase 1 Rattus norvegicus 160-164 15862534-2 2005 Based on their apparent sensitivity to gonadal steroid manipulation, we hypothesized that nNOS cells contain steroid receptors, and the testosterone-induced restoration of nNOS-immunoreactivity in castrates should accompany the restoration of copulation. Steroids 47-54 nitric oxide synthase 1 Rattus norvegicus 90-94 34330716-1 2021 Numerous studies have been reported in the past 50-plus years regarding the stimulatory role of cytochrome b 5 (b 5) in some but not all microsomal cytochrome P450 (P450, CYP) reactions with drugs and steroids. Steroids 201-209 cytochrome b5 type A Homo sapiens 96-110 15870285-7 2005 Immunoprecipitation-immunoblotting, chromatin immunoprecipitation, and GST pull-down assays revealed that silencing mediator for retinoid and thyroid hormone receptors (SMRT), a corepressor recruited to steroid-GR complex for histone deacetylation, bound to TAD domain of C/EBPbeta and Neh4/5 domain of Nrf2. Steroids 203-210 CCAAT/enhancer binding protein beta Rattus norvegicus 272-281 34330716-1 2021 Numerous studies have been reported in the past 50-plus years regarding the stimulatory role of cytochrome b 5 (b 5) in some but not all microsomal cytochrome P450 (P450, CYP) reactions with drugs and steroids. Steroids 201-209 peptidylprolyl isomerase G Homo sapiens 171-174 19164344-0 2009 Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Steroids 30-37 dehydrogenase/reductase 2 Homo sapiens 17-26 34324841-2 2021 Based on C. semilaevis transcriptomic information, 24-dehydrocholesterol reductase (dhcr24) was identified in steroid biosynthesis, showing female-liver-biased expression. Steroids 110-117 delta(24)-sterol reductase Cynoglossus semilaevis 84-90 19375507-0 2009 Autophagy and the functional roles of Atg5 and beclin-1 in the anti-tumor effects of 3beta androstene 17alpha diol neuro-steroid on malignant glioma cells. Steroids 121-128 beclin 1 Homo sapiens 47-55 19375507-6 2009 Silencing of ATG5 or beclin-1 with small interfering RNA significantly reduced the incidence of autophagy in 17alpha-AED treated malignant gliomas and attenuated the cytotoxic effects of the neuro-steroid indicating that the induction of autophagy mediates the anti-glioma activity of 17alpha-AED rather than serving as a cyto-protective response. Steroids 197-204 beclin 1 Homo sapiens 21-29 15769477-1 2005 PBR is involved in numerous biological functions, including steroid biosynthesis, mitochondrial oxidative phosphorylation and cell proliferation. Steroids 60-67 translocator protein Homo sapiens 0-3 15842237-3 2005 Although some studies report that steroid hormones regulate the expression of the inducible transcription factor, Fos, in developing brain, it is not known if there is a sex difference in Fos expression. Steroids 34-41 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 114-117 34324841-8 2021 Finally, dhcr24-siRNA mediated knock-down assay using C. semilaevis liver cells showed that steroid biosynthesis related genes (e.g., ebp, dhcr7, and sc5d), core component of PI3K/Akt pathway (e.g., pi3k), and igf1r exhibited different expression patterns. Steroids 92-99 delta(24)-sterol reductase Cynoglossus semilaevis 9-15 34524336-1 2021 Cytochromes P450 17A1 (CYP7A1) and 21A2 (CYP21A2) catalyze key reactions in the production of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens. Steroids 94-101 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 41-48 15640159-10 2005 CYP17 may therefore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals. Steroids 64-72 cytochrome P450 family 17 subfamily A member 1 L homeolog Xenopus laevis 0-5 15640159-10 2005 CYP17 may therefore have evolved from a general producer of sex steroids in lower vertebrates to a more tightly regulated producer of both sex steroids and glucocorticoids in mammals. Steroids 143-151 cytochrome P450 family 17 subfamily A member 1 L homeolog Xenopus laevis 0-5 19341784-1 2009 Although the ovalbumin (Ov) gene has served as a model to study tissue-specific, steroid hormone-induced gene expression in vertebrates for decades, the mechanisms responsible for regulating this gene remain elusive. Steroids 81-96 ovalbumin (SERPINB14) Gallus gallus 13-22 19341784-1 2009 Although the ovalbumin (Ov) gene has served as a model to study tissue-specific, steroid hormone-induced gene expression in vertebrates for decades, the mechanisms responsible for regulating this gene remain elusive. Steroids 81-96 ovalbumin (SERPINB14) Gallus gallus 24-26 19341784-8 2009 Transfection experiments with OvCAT (chloramphenicol acetyltransferase) reporter constructs demonstrated that both IRF-4 and IRF-10 are capable of repressing the Ov gene even in the presence of steroid hormones and that nucleotides in the ISRE are required for repression. Steroids 194-210 interferon regulatory factor 4 Gallus gallus 115-120 15619230-0 2005 Influence of gonadal steroids on the glial fibrillary acidic protein-immunoreactive astrocyte population in young rat hippocampus. Steroids 21-29 glial fibrillary acidic protein Rattus norvegicus 37-68 15619230-1 2005 It is known that expression of glial fibrillary acidic protein (GFAP) as an astrocyte-specific marker can be regulated by levels of circulating gonadal steroids during postnatal development. Steroids 152-160 glial fibrillary acidic protein Rattus norvegicus 31-62 15619230-1 2005 It is known that expression of glial fibrillary acidic protein (GFAP) as an astrocyte-specific marker can be regulated by levels of circulating gonadal steroids during postnatal development. Steroids 152-160 glial fibrillary acidic protein Rattus norvegicus 64-68 34575929-2 2021 We recently reported that cell adhesion molecule protocadherin 19 (encoded by the PCDH19 gene) is involved in the coregulation of steroid receptor activity on gene expression. Steroids 130-137 protocadherin 19 Homo sapiens 49-65 19380520-8 2009 This study shows that while not a significant inhibitor of Wnt-1-driven breast cancer, p27 inhibits gastric tumors, whose latency is modulated by sex steroids. Steroids 150-158 cyclin-dependent kinase inhibitor 1B Mus musculus 87-90 34575929-2 2021 We recently reported that cell adhesion molecule protocadherin 19 (encoded by the PCDH19 gene) is involved in the coregulation of steroid receptor activity on gene expression. Steroids 130-137 protocadherin 19 Homo sapiens 82-88 15699741-8 2005 In the clinic, the current strategy of profoundly inhibiting immune activation (in particular Th1 cytokines/responses) by using high dose calcineurin inhibitors and steroids may prove antagonistic with the development of tolerance, particularly when immunomodulatory strategies (such as DSBT) are applied. Steroids 165-173 negative elongation factor complex member C/D Homo sapiens 94-97 34348164-5 2021 Nrf2-Keap1 signaling is activated downstream of the steroid hormone ecdysone. Steroids 52-59 Keap1 Drosophila melanogaster 5-10 15692981-13 2005 CONCLUSION: Over the short term, local steroid injection is better than surgical decompression for the symptomatic relief of CTS. Steroids 39-46 transthyretin Homo sapiens 125-128 15692981-14 2005 At 1 year, local steroid injection is as effective as surgical decompression for the symptomatic relief of CTS. Steroids 17-24 transthyretin Homo sapiens 107-110 19232336-1 2009 OBJECTIVES: To study the interplay between serum concentrations of homocysteine, steroid hormones and vitamins B and mutations in 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, in association to Alzheimer"s type dementia (ATD). Steroids 81-88 methylenetetrahydrofolate reductase Homo sapiens 172-177 19342447-2 2009 We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss, and Dhcr7 in murine osteoprogenitor cells. Steroids 94-101 cytochrome P450, family 39, subfamily a, polypeptide 1 Mus musculus 133-140 34348164-8 2021 This study reveals an epistatic link between the Nrf2-Keap1 pathway and steroid hormone signaling and demonstrates an antioxidant-independent but proteasome-dependent role of the Nrf2-Keap1 pathway in neuronal remodeling. Steroids 72-79 Keap1 Drosophila melanogaster 54-59 34348164-8 2021 This study reveals an epistatic link between the Nrf2-Keap1 pathway and steroid hormone signaling and demonstrates an antioxidant-independent but proteasome-dependent role of the Nrf2-Keap1 pathway in neuronal remodeling. Steroids 72-79 Keap1 Drosophila melanogaster 184-189 34344357-17 2021 The potential mechanism may be related to IL-1beta augmenting TGF-beta1-induced steroid-resistant EMT through MAPK signaling pathways. Steroids 80-87 interleukin 1 alpha Homo sapiens 42-50 19117688-9 2009 These observations suggest that the 3beta-HSD inhibitor trilostane present antidepressant-like activity, putatively by regulating brain and peripheral levels of neuroactive steroids. Steroids 173-181 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 36-45 15537867-0 2005 Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Steroids 34-42 ATP binding cassette subfamily C member 11 Homo sapiens 105-136 15537867-0 2005 Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Steroids 34-42 ATP binding cassette subfamily C member 11 Homo sapiens 137-143 15537867-8 2005 These results suggest that MRP8 participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides and indicate that the pump has complex interactions with its substrates. Steroids 105-113 ATP binding cassette subfamily C member 11 Homo sapiens 27-31 19250945-8 2009 Furthermore, we have limited our discussions to the importance of oxytocin and vasopressin as targets of gonadal steroids and how these effects are modified by genetic and experiential situations. Steroids 113-121 oxytocin/neurophysin I prepropeptide Homo sapiens 66-74 34120034-6 2021 The results obtained in this study showed that the cyp19a aromatase system, involved in the synthesis of steroid compounds, is specially located in distinct oocyte stages in the ovary (cyp19a1a) and in radial glial cells of the brain (cyp19a1b). Steroids 105-112 cytochrome P450, family 19, subfamily A, polypeptide 1a Danio rerio 51-57 15516533-5 2005 In steroid-naive patients, but not in patients using inhaled corticosteroids, enhanced platelet BDNF levels correlated with parameters of airway obstruction and airway hyperresponsiveness to histamine. Steroids 3-10 brain derived neurotrophic factor Homo sapiens 96-100 34301840-0 2021 Cutting Edge: Steroid Responsiveness in Foxp3+ Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice. Steroids 14-21 forkhead box P3 Mus musculus 40-45 15642785-6 2005 Steroid assays showed a clear correlation between circulating corticosterone and inner zone mitochondrial MnSOD, but none between aldosterone and glomerulosa MnSOD. Steroids 0-7 superoxide dismutase 2 Rattus norvegicus 106-111 19416784-4 2009 All 3 patients presented with atypical features of Aspergillus infection, but all responded to treatments with either steroids, anti-fungals or both. Steroids 118-126 paired box 5 Homo sapiens 0-5 19404334-3 2009 The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling. Steroids 191-206 Signal-transducer and activator of transcription protein at 92E Drosophila melanogaster 72-76 16183203-0 2005 Glutamatergic stimulation of the medial amygdala induces steroid dependent c-fos expression within forebrain nuclei responsive to mating stimulation. Steroids 57-64 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-80 34301840-0 2021 Cutting Edge: Steroid Responsiveness in Foxp3+ Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice. Steroids 77-84 forkhead box P3 Mus musculus 40-45 19158194-0 2009 Retinol-binding protein 4 in polycystic ovary syndrome--association with steroid hormones and response to pioglitazone treatment. Steroids 73-89 retinol binding protein 4 Homo sapiens 0-25 19158194-12 2009 The molecular involvement of RBP4 in human steroid metabolism requires further clarification. Steroids 43-50 retinol binding protein 4 Homo sapiens 29-33 34301840-4 2021 Foxp3+ regulatory T cells (Tregs) were required during dexamethasone/IL-27 treatment of steroid-resistant allergic inflammation, and importantly, direct stimulation of Tregs via glucocorticoid or IL-27 receptors was essential. Steroids 88-95 forkhead box P3 Mus musculus 0-5 15358680-6 2004 To test this hypothesis, DAX-1 was overexpressed in the R2C cells using the Tet-on inducible gene expression system and resulted in a 45% decrease in steroid production, a 35% decrease in StAR protein, and a 39% decrease in cytochrome P450 side chain cleavage expression. Steroids 150-157 nuclear receptor subfamily 0, group B, member 1 Rattus norvegicus 25-30 34218929-7 2022 On multivariable analysis, having CP did not increase the odds of postoperative morbidity (OR 0.99, 95% CI 0.7-1.3), but higher ASA class, congenital lung malformation, gastrointestinal disease, coagulopathy, preoperative inotropic support, oxygen use, nutritional support, and steroid use significantly increase the odds of morbidity, all of which were more common in patients with CP. Steroids 278-285 ceruloplasmin Homo sapiens 383-385 15358680-8 2004 These results corroborate previous findings that DAX-1 negatively regulates steroid synthesis through the inhibition of StAR expression and indicate that the absence of DAX-1 in R2C cells is, at least in part, responsible for the constitutive steroidogenesis and StAR expression observed. Steroids 76-83 nuclear receptor subfamily 0, group B, member 1 Rattus norvegicus 49-54 15645014-2 2004 Human AKR members that may regulate the local concentration of steroid hormones include: AKR1C1, AKR1C2, AKR1C3, AKR1C4 and AKR1D1. Steroids 63-79 aldo-keto reductase family 1 member C4 Homo sapiens 113-119 18317463-5 2009 The results support the hypothesis that the A(-656) allele contributes to the development of MDD in women through selective alteration of CREB1 promoter activity by female gonadal steroids in noradrenergic neuronal cells. Steroids 180-188 cAMP responsive element binding protein 1 Homo sapiens 138-143 34103681-5 2021 In this study, we show that cytoplasmic complexes composed of steroid receptor (SR) co-activators, PELP1 and SRC-3, modulate breast CSC expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4. Steroids 62-69 nuclear receptor coactivator 3 Homo sapiens 109-114 18992099-9 2009 The detection of ERalpha, ERbeta and PR in foetal and maternal vascular tissue suggests that placental steroids are also involved in the control of placental angiogenesis and /or vascular functions. Steroids 103-111 estrogen receptor 1 Equus caballus 17-24 15340917-1 2004 In steroid hydroxylation system in adrenal cortex mitochondria, NADPH-adrenodoxin reductase (AR) and adrenodoxin (Adx) form a short electron-transport chain that transfers electrons from NADPH to cytochromes P-450 through FAD in AR and [2Fe-2S] cluster in Adx. Steroids 3-10 ferredoxin 1 Homo sapiens 70-81 15340917-1 2004 In steroid hydroxylation system in adrenal cortex mitochondria, NADPH-adrenodoxin reductase (AR) and adrenodoxin (Adx) form a short electron-transport chain that transfers electrons from NADPH to cytochromes P-450 through FAD in AR and [2Fe-2S] cluster in Adx. Steroids 3-10 ferredoxin 1 Homo sapiens 101-112 15340917-1 2004 In steroid hydroxylation system in adrenal cortex mitochondria, NADPH-adrenodoxin reductase (AR) and adrenodoxin (Adx) form a short electron-transport chain that transfers electrons from NADPH to cytochromes P-450 through FAD in AR and [2Fe-2S] cluster in Adx. Steroids 3-10 ferredoxin 1 Homo sapiens 114-117 15340917-1 2004 In steroid hydroxylation system in adrenal cortex mitochondria, NADPH-adrenodoxin reductase (AR) and adrenodoxin (Adx) form a short electron-transport chain that transfers electrons from NADPH to cytochromes P-450 through FAD in AR and [2Fe-2S] cluster in Adx. Steroids 3-10 ferredoxin 1 Homo sapiens 256-259 34103681-5 2021 In this study, we show that cytoplasmic complexes composed of steroid receptor (SR) co-activators, PELP1 and SRC-3, modulate breast CSC expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4. Steroids 62-69 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 211-217 19026618-5 2009 Expression of the point mutation F218Y HSDL1 though, resulted in the detection of weak dehydrogenase activity towards steroid and retinoid substrates. Steroids 118-125 hydroxysteroid dehydrogenase like 1 Homo sapiens 39-44 34103681-5 2021 In this study, we show that cytoplasmic complexes composed of steroid receptor (SR) co-activators, PELP1 and SRC-3, modulate breast CSC expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4. Steroids 62-69 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Homo sapiens 222-228 15635500-5 2004 Much of the steroid released by the fetal zone is DHEA-S, which is used by the placenta to produce estrogens. Steroids 12-19 sulfotransferase family 2A member 1 Homo sapiens 50-56 34103805-1 2021 Steroid 5alpha-reductase deficiency (5ARD) is a rare autosomal recessive disorder caused by mutation in the 5alpha-reductase type 2 gene (SRD5A2). Steroids 0-7 steroid 5 alpha-reductase 2 Homo sapiens 138-144 15242985-6 2004 Hypothalamic expression of KiSS-1 and GPR54 genes changed throughout the estrous cycle and was significantly increased after gonadectomy, a rise that was prevented by sex steroid replacement both in males and females. Steroids 171-178 KiSS-1 metastasis-suppressor Rattus norvegicus 27-33 19231202-0 2009 Inhibition of Trypanosoma brucei glucose-6-phosphate dehydrogenase by human steroids and their effects on the viability of cultured parasites. Steroids 76-84 glucose-6-phosphate dehydrogenase Homo sapiens 33-66 19231202-1 2009 Dehydroepiandrosterone (DHEA) is known as an intermediate in the synthesis of mammalian steroids and a potent uncompetitive inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH), but not the enzyme from plants and lower eukaryotes. Steroids 88-96 glucose-6-phosphate dehydrogenase Homo sapiens 182-187 34225936-12 2021 Taken together, sex differences in KP and NKB expression most likely reflect organizational actions of sex steroid hormones on the developing brain but they also remain sensitive to circulating sex steroids in adulthood. Steroids 107-114 tachykinin precursor 3 Homo sapiens 42-45 34225936-12 2021 Taken together, sex differences in KP and NKB expression most likely reflect organizational actions of sex steroid hormones on the developing brain but they also remain sensitive to circulating sex steroids in adulthood. Steroids 198-206 tachykinin precursor 3 Homo sapiens 42-45 15356574-1 2004 BACKGROUND: Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown. Steroids 69-76 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 58-62 35398259-3 2022 Previous study suggested that, among the porcine AKR1Cs, AKR1C1 and AKR1C4 play important roles in steroid hormone metabolism in the reproductive tissues; however, their biological functions are still unknown. Steroids 99-106 aldo-keto reductase family 1 member C1 Homo sapiens 57-63 19457780-1 2009 Oxytocin (OT) is involved in the regulation of steroid secretion by the corpus luteum (CL) in pigs, but OT signal transduction in the porcine CL has not been identified. Steroids 47-54 oxytocin/neurophysin I prepropeptide Sus scrofa 0-8 35398259-5 2022 Kinetic and product analyses of steroid specificity indicated that AKR1C1 is a multi-specific reductase, which acts as 3alpha-HSD for 3-keto-5beta-dihydro-C19/C21-steroids, 3beta-HSD for 3-keto-5alpha-dihydro-C19-steroids including androstenone, 17beta-HSD for 17-keto-C19-steroids including estrone, and 20alpha-HSD for progesterone, showing Km values of 0.5-11microM. Steroids 32-39 aldo-keto reductase family 1 member C1 Homo sapiens 67-73 15604743-3 2004 We have previously generated Arabidopsis plants expressing four pathogen-regulated CRK genes (CRK5, 6, 10 and 11) under control of a steroid-inducible promoter and found that induced expression of CRK5, but not the other three CRK genes, triggered hypersensitive response-like cell death in transgenic plants. Steroids 133-140 ARP2/3 complex 16 kDa subunit (p16-Arc) Arabidopsis thaliana 83-86 15604743-3 2004 We have previously generated Arabidopsis plants expressing four pathogen-regulated CRK genes (CRK5, 6, 10 and 11) under control of a steroid-inducible promoter and found that induced expression of CRK5, but not the other three CRK genes, triggered hypersensitive response-like cell death in transgenic plants. Steroids 133-140 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 94-112 35398259-5 2022 Kinetic and product analyses of steroid specificity indicated that AKR1C1 is a multi-specific reductase, which acts as 3alpha-HSD for 3-keto-5beta-dihydro-C19/C21-steroids, 3beta-HSD for 3-keto-5alpha-dihydro-C19-steroids including androstenone, 17beta-HSD for 17-keto-C19-steroids including estrone, and 20alpha-HSD for progesterone, showing Km values of 0.5-11microM. Steroids 32-39 aldo-keto reductase family 1 member C1 Homo sapiens 305-316 15604743-3 2004 We have previously generated Arabidopsis plants expressing four pathogen-regulated CRK genes (CRK5, 6, 10 and 11) under control of a steroid-inducible promoter and found that induced expression of CRK5, but not the other three CRK genes, triggered hypersensitive response-like cell death in transgenic plants. Steroids 133-140 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 94-98 15604743-3 2004 We have previously generated Arabidopsis plants expressing four pathogen-regulated CRK genes (CRK5, 6, 10 and 11) under control of a steroid-inducible promoter and found that induced expression of CRK5, but not the other three CRK genes, triggered hypersensitive response-like cell death in transgenic plants. Steroids 133-140 ARP2/3 complex 16 kDa subunit (p16-Arc) Arabidopsis thaliana 94-97 35135181-4 2022 Sequence variants of steroid 5-alpha-reductase type 2 (SRD5A2) were analyzed in cases with testostetone/dihydrotestosterone (T/DHT) ratio >= 20, whereas androgen receptor (AR) gene was screened when the ratio was below 20. Steroids 21-28 steroid 5 alpha-reductase 2 Homo sapiens 55-61 15255978-1 2004 The peripheral benzodiazepine receptor (PBR), a benzodiazepine but not gamma-aminobutyric acid-binding mitochondrial membrane protein, has roles in steroid production, energy metabolism, cell survival and growth. Steroids 148-155 translocator protein Rattus norvegicus 4-38 15255978-1 2004 The peripheral benzodiazepine receptor (PBR), a benzodiazepine but not gamma-aminobutyric acid-binding mitochondrial membrane protein, has roles in steroid production, energy metabolism, cell survival and growth. Steroids 148-155 translocator protein Rattus norvegicus 40-43 19153534-11 2009 The RANTES-mediated pathway may be involved in the improvement of the airflow limitation and airway lability by LM additive therapy in asthmatics receiving steroid therapy. Steroids 156-163 C-C motif chemokine ligand 5 Homo sapiens 4-10 35628892-8 2022 In three children there was a need to use steroids to resolve PIMS-TS/MIS-C symptoms. Steroids 42-50 anti-Mullerian hormone Homo sapiens 70-73 19056481-1 2009 Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids. Steroids 181-197 farnesyl diphosphate synthase Homo sapiens 0-31 19056481-1 2009 Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids. Steroids 181-197 farnesyl diphosphate synthase Homo sapiens 33-37 19210296-9 2009 The steroid-sensitive changes in kiss1 mRNA expression in the NVT occur physiologically, closely linked to the reproductive state. Steroids 4-11 metastasis-suppressor KiSS-1 Oryzias latipes 33-38 19159066-0 2009 Steroid-responsive edema in CAA-related inflammation. Steroids 0-7 teashirt zinc finger homeobox 1 Homo sapiens 28-31 15316506-9 2004 Prior exposure of CD4+CD25+ T cells to FP also increased subsequent IL-10 production by these cells when stimulated with allergen, and addition of anti-IL-10 antibody reversed the steroid-induced enhancement of suppression in mixed cultures. Steroids 180-187 interleukin 10 Homo sapiens 68-73 15316506-9 2004 Prior exposure of CD4+CD25+ T cells to FP also increased subsequent IL-10 production by these cells when stimulated with allergen, and addition of anti-IL-10 antibody reversed the steroid-induced enhancement of suppression in mixed cultures. Steroids 180-187 interleukin 10 Homo sapiens 152-157 15243798-1 2004 3Beta-hydroxysteroid-dehydrogenase (3beta-HSD) is an isoenzyme that catalyses an essential step in the synthesis of all classes of active steroid hormones. Steroids 138-154 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 36-45 35578937-13 2022 Steroids can be used for the treatment of G-CSF-induced aortitis. Steroids 0-8 colony stimulating factor 3 Homo sapiens 42-47 15284501-4 2004 As rim enhancement consists of a macrophage infiltrate, periradicular steroid could theoretically interfere with the resorption process. Steroids 70-77 regulating synaptic membrane exocytosis 1 Homo sapiens 3-6 15288770-8 2004 We found that 1,25D3-promoted ion channel responses are coupled to secretion in calvarial osteoblasts, and develop only in the presence of a functional nuclear steroid VDR. Steroids 160-167 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 168-171 15242697-3 2004 Steroids modulate some plasma cytokines (decreasing TNFalpha, IL-8, IL-6 and increasing IL-10), whereas ability to reduce plasma and urinary TNFsr-2 and IL-1ra and peri-operative renal injury is unknown. Steroids 0-8 interleukin 10 Homo sapiens 88-93 19015234-1 2009 Steroidogenic factor 1 (SF-1) is an orphan nuclear receptor selectively expressed in the adrenal cortex and gonads, where it mediates the hormonal stimulation of multiple genes involved in steroid hormone biosynthesis. Steroids 189-204 splicing factor 1 Homo sapiens 0-28 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 51-58 interleukin 17A Homo sapiens 10-16 18226957-3 2009 We report the case of a patient with a serum anti-AQP4 antibody who presented with recurrent hypersomnia, symmetrical hypothalamic lesions with long spinal cord lesions on MRI, and a reduced CSF orexin (hypocretin) level, all of which were improved simultaneously by steroid therapy. Steroids 267-274 aquaporin 4 Homo sapiens 50-54 19063914-1 2009 DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear. Steroids 19-27 sulfotransferase family 2A member 1 Homo sapiens 9-14 18923000-2 2009 These steroid hormones mediate their actions by binding to the androgen receptor (AR). Steroids 6-22 androgen receptor Mus musculus 82-84 18936985-0 2009 Receptor independent and receptor dependent CoMSA modeling with IVE-PLS: application to CBG benchmark steroids and reductase activators. Steroids 102-110 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 88-91 18936985-1 2009 Comparative molecular surface analysis (CoMSA) with robust IVE-PLS variable elimination if tested for the benchmark CBG steroid series provides highly predictive RI 3D QSAR models, but failed however to model the activity of sulforaphane (SP) activators of quinone reductase. Steroids 120-127 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 116-119 19147544-2 2009 Like other KLKs, such as KLK3/PSA and KLK2, KLK4 gene expression is also regulated by steroid hormones in hormone-dependent cancers, although the transcriptional mechanisms are ill defined. Steroids 86-102 kallikrein related peptidase 4 Homo sapiens 44-48 19401759-9 2009 In contrast, clinically steroid unresponsive patients demonstrated high basal levels of mIL1R2 in their PBMC and only minimally augmented expression in response to dexamethasone. Steroids 24-31 interleukin 1 receptor, type II Mus musculus 88-94 19536350-2 2009 This implies modulation of female sex steroid hormones by PPARgamma. Steroids 38-45 peroxisome proliferator-activated receptor gamma Rattus norvegicus 58-67 19536350-4 2009 Because PPARgamma activation by thiazolidinedione increased insulin sensitivity in type 2 diabetes, understanding the long term impact of PPARgamma activation on steroid sex hormones in males is critical. Steroids 162-169 peroxisome proliferator-activated receptor gamma Rattus norvegicus 138-147 18832183-7 2009 Next, we examined the effects of several pesticides, plasticizers, steroids, and bile acids on CAR activation. Steroids 67-75 nuclear receptor subfamily 1 group I member 3 Homo sapiens 95-98 20058813-1 2009 Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and cell proliferation. Steroids 113-120 translocator protein Homo sapiens 0-34 20058813-1 2009 Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and cell proliferation. Steroids 113-120 translocator protein Homo sapiens 36-39 20058813-1 2009 Peripheral benzodiazepine receptor (PBR, TsPO) is an outer mitochondrial membrane protein which is implicated in steroid biosynthesis regulation, apoptosis and cell proliferation. Steroids 113-120 translocator protein Homo sapiens 41-45 18617612-8 2008 Comparison of OVX and OVX+E ewes in the breeding and nonbreeding season revealed a greater effect of steroid replacement on inhibition of kisspeptin protein and Kiss1 mRNA expression during the nonbreeding season. Steroids 101-108 metastasis-suppressor KiSS-1 Ovis aries 138-148 18617612-8 2008 Comparison of OVX and OVX+E ewes in the breeding and nonbreeding season revealed a greater effect of steroid replacement on inhibition of kisspeptin protein and Kiss1 mRNA expression during the nonbreeding season. Steroids 101-108 metastasis-suppressor KiSS-1 Ovis aries 161-166 18799130-6 2008 These results indicate that coordinated de novo transcription of genes encoding StAR as well as 3beta-HSD, P450c17 and 11beta-HSD might be required for sex steroids production during the initiation of spermatogenesis in salmon. Steroids 156-164 steroidogenic acute regulatory protein, mitochondrial Salmo salar 80-84 18765637-1 2008 Overexpression and activation of the steroid receptor coactivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been shown to have a critical role in oncogenesis and are required for both steroid and growth factor signaling in epithelial tumors. Steroids 37-44 nuclear receptor coactivator 3 Mus musculus 96-100 18765637-1 2008 Overexpression and activation of the steroid receptor coactivator amplified in breast cancer 1 (AIB1)/steroid receptor coactivator-3 (SRC-3) have been shown to have a critical role in oncogenesis and are required for both steroid and growth factor signaling in epithelial tumors. Steroids 37-44 nuclear receptor coactivator 3 Mus musculus 134-139 18852653-0 2008 ABO incompatible living renal transplantation with a steroid sparing protocol. Steroids 53-60 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 0-3 18596217-11 2008 Taken together, the data from our comparative study provide evidence that PRLR can be regulated by an interplay of two different mechanisms, PRL or ovarian steroid hormones independently or in combination in a tissue-specific manner. Steroids 156-172 prolactin Mus musculus 74-77 18463322-9 2008 When IgAN patients had >32.6 FSP1(+) cells/HPF at diagnosis, they were the more likely to show steroid resistance. Steroids 98-105 S100 calcium binding protein A4 Homo sapiens 32-36 19337163-9 2008 Sex steroids probably act by increasing the expression of RANKL by osteoblastic cells, and alterations in the RANK/RANKL/OPG system in favour of osteoclasts are characteristic in TM, where the ratio of sRANKL/OPG is increased. Steroids 4-12 TNF superfamily member 11 Homo sapiens 58-63 18495669-0 2008 Steroid treatment causes deterioration of myocardial function in the {delta}-sarcoglycan-deficient mouse model for dilated cardiomyopathy. Steroids 0-7 sarcoglycan, delta (dystrophin-associated glycoprotein) Mus musculus 70-88 18837747-0 2008 Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) with negative thyroperoxidase antibodies. Steroids 0-7 thyroid peroxidase Homo sapiens 95-110 18562571-3 2008 In this study, a lifetime Markov model was created to compare the cost-effectiveness of a sirolimus-based CNI withdrawal regimen (sirolimus plus steroids) with other common CNI-containing regimens in adult de novo renal transplantation patients. Steroids 145-153 calcineurin binding protein 1 Homo sapiens 106-109 18472120-4 2008 For this purpose, we determined the relative binding affinity (RBA) of steroids 9a-9d to androgen receptor (AR) obtained from rat prostate cytosol, using labeled mibolerone (MIB) as ligand. Steroids 71-79 androgen receptor Rattus norvegicus 89-106 18472120-4 2008 For this purpose, we determined the relative binding affinity (RBA) of steroids 9a-9d to androgen receptor (AR) obtained from rat prostate cytosol, using labeled mibolerone (MIB) as ligand. Steroids 71-79 androgen receptor Rattus norvegicus 108-110 18625290-2 2008 Using an experimental protocol, in which crush injury was applied 1 cm above the bifurcation of the rat sciatic nerve for 20 s, we here demonstrate that the levels of neuroactive steroids, such as pregnenolone and progesterone (P) metabolites (i.e. dihydroprogesterone, DHP, and tetrahydroprogesterone, THP) present in injured sciatic nerve were significantly decreased. Steroids 179-187 dihydropyrimidinase Rattus norvegicus 270-273 18625290-6 2008 Altogether, these observations suggest that DHP and P (i.e. two neuroactive steroids interacting with progesterone receptor) may be considered protective agents in case of nerve crush injury. Steroids 76-84 dihydropyrimidinase Rattus norvegicus 44-47 18656987-5 2008 The biological activities of all 16 steroids were tested using the cAMP assay on GPR12-CHO and WT-CHO cells. Steroids 36-44 G-protein coupled receptor 12 Cricetulus griseus 81-86 18603420-6 2008 We observed statistically significant correlations between the concentrations of RANTES in EBC and F(ENO) in the three studied groups of asthmatics; notably, the correlation between the parameters described above was strong positive in the group of unstable and steroid-naive stable asthmatics. Steroids 262-269 C-C motif chemokine ligand 5 Homo sapiens 81-87 18603420-7 2008 We also discovered a significantly positive correlation between RANTES in EBC and the serum ECP or blood eosinophil count in the groups of asthmatics with severe, unstable asthma and between RANTES and serum ECP in the group of steroid-naive stable asthmatics. Steroids 228-235 C-C motif chemokine ligand 5 Homo sapiens 64-70 18603420-7 2008 We also discovered a significantly positive correlation between RANTES in EBC and the serum ECP or blood eosinophil count in the groups of asthmatics with severe, unstable asthma and between RANTES and serum ECP in the group of steroid-naive stable asthmatics. Steroids 228-235 C-C motif chemokine ligand 5 Homo sapiens 191-197 18603420-7 2008 We also discovered a significantly positive correlation between RANTES in EBC and the serum ECP or blood eosinophil count in the groups of asthmatics with severe, unstable asthma and between RANTES and serum ECP in the group of steroid-naive stable asthmatics. Steroids 228-235 ribonuclease A family member 3 Homo sapiens 208-211 18497332-0 2008 Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Steroids 58-65 solute carrier family 51, alpha subunit Mus musculus 0-8 18560271-2 2008 Recent studies on the role of Fkh in autophagic cell death during Drosophila metamorphosis identified Fkh as a competence factor for steroid-induced cell death. Steroids 133-140 fork head Drosophila melanogaster 30-33 18560271-2 2008 Recent studies on the role of Fkh in autophagic cell death during Drosophila metamorphosis identified Fkh as a competence factor for steroid-induced cell death. Steroids 133-140 fork head Drosophila melanogaster 102-105 18403176-3 2008 Consequently, increased IGF-I expression may play a role in anabolic-steroid-enhanced muscle growth. Steroids 69-76 IGFI Bos taurus 24-29 18624678-5 2008 By using the PXR knockout and humanized mouse models, PXR was found to influence drug-drug interactions, hepatic steatosis, and the homeostasis of vitamin D, bile acids, and steroid hormones. Steroids 174-190 nuclear receptor subfamily 1, group I, member 2 Mus musculus 54-57 18797057-0 2008 An open labeled, comparative clinical study on efficacy and tolerability of oral minipulse of steroid (OMP) alone, OMP with PUVA and broad / narrow band UVB phototherapy in progressive vitiligo. Steroids 94-101 olfactory marker protein Homo sapiens 103-106 18797057-11 2008 CONCLUSIONS: Our study compared four treatment modalities in vitiligo patients, out of which oral minipulse of steroids (OMP) only had an adjunct value and was not very effective by itself. Steroids 111-119 olfactory marker protein Homo sapiens 121-124 18417530-8 2008 Incubation of Y1-BS1 cells with either MnTMPyP or NAC also upregulated Bt(2)cAMP and Bt(2)cAMP+hHDL(3)-stimulated steroid synthesis, indicating that endogenously produced ROS can inhibit steroidogenesis. Steroids 114-121 NLR family, pyrin domain containing 1A Mus musculus 50-53 18552607-1 2008 PURPOSE: To find out the relationship between steroid-induced intraocular pressure (IOP) rise and the plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-2 (TIMP-2) in diabetic patients who underwent intravitreal triamcinolone acetonide (IVTA) injection for the treatment of diabetic macular edema. Steroids 46-53 matrix metallopeptidase 9 Homo sapiens 119-145 18552607-1 2008 PURPOSE: To find out the relationship between steroid-induced intraocular pressure (IOP) rise and the plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-2 (TIMP-2) in diabetic patients who underwent intravitreal triamcinolone acetonide (IVTA) injection for the treatment of diabetic macular edema. Steroids 46-53 matrix metallopeptidase 9 Homo sapiens 147-152 18552607-1 2008 PURPOSE: To find out the relationship between steroid-induced intraocular pressure (IOP) rise and the plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-2 (TIMP-2) in diabetic patients who underwent intravitreal triamcinolone acetonide (IVTA) injection for the treatment of diabetic macular edema. Steroids 46-53 TIMP metallopeptidase inhibitor 2 Homo sapiens 158-183 18552607-1 2008 PURPOSE: To find out the relationship between steroid-induced intraocular pressure (IOP) rise and the plasma levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of MMP-2 (TIMP-2) in diabetic patients who underwent intravitreal triamcinolone acetonide (IVTA) injection for the treatment of diabetic macular edema. Steroids 46-53 TIMP metallopeptidase inhibitor 2 Homo sapiens 185-191 18391015-6 2008 Interestingly, we found that both thyroid and steroid hormones stimulate MED1 phosphorylation in vivo and that MED1 phosphorylation is required for its nuclear hormone receptor coactivator activity. Steroids 46-53 mediator complex subunit 1 Homo sapiens 73-77 18215136-1 2008 Steroid 5alpha-reductase 1 (5alpha-R1), a key enzyme in the conversion of steroids into their respective 5alpha-reduced derivatives, plays a key role in some hormone-dependent tumours and is abundant in the liver, although it is also widely distributed throughout the body. Steroids 74-82 steroid 5 alpha-reductase 1 Homo sapiens 0-26 18174359-1 2008 Steroids are synthesized mainly from the adrenal glands catalyzed by steroidogenic enzymes; the expression of these enzymes is controlled by transcription factor steroidogenic factor-1 (SF-1; NR5A1). Steroids 0-8 nuclear receptor subfamily 5, group A, member 1 Mus musculus 192-197 18367609-8 2008 Our results indicate that the decay kinetics of GABA(A) receptor-mediated mIPSCs in the DH of the spinal cord are primarily controlled by 3alpha5alpha-reduced steroids, which can be produced from circulating steroid precursors and/or in a spatially restricted manner by the modulation of the activity of TSPO. Steroids 159-166 translocator protein Rattus norvegicus 304-308 18180294-1 2008 The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin. Steroids 191-199 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 56-60 17509691-0 2008 Kisspeptin signalling in the brain: steroid regulation in the rodent and ewe. Steroids 36-43 metastasis-suppressor KiSS-1 Ovis aries 0-10 17509691-6 2008 Thus, sex steroids are able to directly regulate the expression of Kiss1 mRNA, implicating kisspeptins as the "missing link" between sex steroid feedback and GnRH secretion. Steroids 10-18 metastasis-suppressor KiSS-1 Ovis aries 67-72 17509691-6 2008 Thus, sex steroids are able to directly regulate the expression of Kiss1 mRNA, implicating kisspeptins as the "missing link" between sex steroid feedback and GnRH secretion. Steroids 10-17 metastasis-suppressor KiSS-1 Ovis aries 67-72 17509691-8 2008 In the arcuate nucleus (ARC) of the rodent and the ewe, sex steroids inhibit the expression of Kiss1 mRNA, suggesting that the kisspeptin secreting neurons here are the conduit for the negative feedback regulation of GnRH secretion. Steroids 60-68 metastasis-suppressor KiSS-1 Ovis aries 95-100 17509691-8 2008 In the arcuate nucleus (ARC) of the rodent and the ewe, sex steroids inhibit the expression of Kiss1 mRNA, suggesting that the kisspeptin secreting neurons here are the conduit for the negative feedback regulation of GnRH secretion. Steroids 60-68 metastasis-suppressor KiSS-1 Ovis aries 127-137 17509691-9 2008 However, in the rodent anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of Kiss1, implying that these kisspeptin neurons play a role in the positive feedback regulation of GnRH secretion. Steroids 73-81 metastasis-suppressor KiSS-1 Ovis aries 107-112 17509691-9 2008 However, in the rodent anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of Kiss1, implying that these kisspeptin neurons play a role in the positive feedback regulation of GnRH secretion. Steroids 73-81 metastasis-suppressor KiSS-1 Ovis aries 134-144 17509691-11 2008 Thus, kisspeptin neurons in the ARC of the ewe appear well placed to play a role in the negative and positive feedback regulation of GnRH exerted by sex steroids. Steroids 153-161 metastasis-suppressor KiSS-1 Ovis aries 6-16 18270434-9 2008 This study demonstrated that the expression of periostin/OSF-2 is regulated by ovarian steroid hormones in rat uterus and human endometrium. Steroids 87-103 periostin Rattus norvegicus 47-56 18240998-5 2008 Of indisputable significance are the data demonstrating that knocking down of the BRCA1 gene is accompanied by aromatase overexpression and the abolishment of IGF-1 receptor expression suppression, thus increasing both steroid and insulin signaling. Steroids 219-226 BRCA1 DNA repair associated Homo sapiens 82-87 17905618-1 2008 Extending a previous investigation, the ability of binding to the model calycin beta-lactoglobulin (BLG) was evaluated both in silico and in vitro for several fluorine-containing (semi-)synthetic molecules of pharmacological and pharmaceutical interest (antibiotics, vastatins, steroid drugs). Steroids 278-285 beta-lactoglobulin Bos taurus 80-98 17905618-1 2008 Extending a previous investigation, the ability of binding to the model calycin beta-lactoglobulin (BLG) was evaluated both in silico and in vitro for several fluorine-containing (semi-)synthetic molecules of pharmacological and pharmaceutical interest (antibiotics, vastatins, steroid drugs). Steroids 278-285 beta-lactoglobulin Bos taurus 100-103 18024509-1 2008 Type I human hepatic 3alpha-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism. Steroids 118-133 aldo-keto reductase family 1 member C4 Homo sapiens 58-64 18155828-7 2008 In the context of the ovary, FOXL2 has been suggested to be involved in the regulation of cholesterol and steroid metabolism, apoptosis, reactive oxygen species detoxification and inflammation processes. Steroids 106-113 forkhead box L2 Homo sapiens 29-34 18226251-0 2008 Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Steroids 50-58 surfactant protein D Homo sapiens 65-85 18226251-0 2008 Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Steroids 50-58 surfactant protein D Homo sapiens 87-91 18226251-15 2008 Further, we speculate that inhaled steroids may induce SP-D expression and that this mechanism may contribute to their beneficial effects in COPD. Steroids 35-43 surfactant protein D Homo sapiens 55-59 18027383-9 2008 The steroid group had increased interleukin 10 levels (P = 0.005 compared to controls). Steroids 4-11 interleukin 10 Homo sapiens 32-46 18193176-6 2008 Expression of Kiss1 in these neurons is differentially regulated by sex steroids providing a mechanism by which testosterone or estrogen can regulate GnRH release. Steroids 72-80 KiSS-1 metastasis suppressor Homo sapiens 14-19 17764761-2 2007 We have identified the progranulin (PGRN) gene as one of the sex steroid-inducible genes that may be involved in masculinization of the rat brain. Steroids 65-72 granulin precursor Rattus norvegicus 23-34 17764761-2 2007 We have identified the progranulin (PGRN) gene as one of the sex steroid-inducible genes that may be involved in masculinization of the rat brain. Steroids 65-72 granulin precursor Rattus norvegicus 36-40 17916741-0 2007 Uteroglobin: a steroid-inducible immunomodulatory protein that founded the Secretoglobin superfamily. Steroids 15-22 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 0-11 17916741-1 2007 Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. Steroids 37-44 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 0-11 17916741-1 2007 Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. Steroids 37-44 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 15-26 17711855-4 2007 Using crystal structures of the hARLBD, we first found that H12 could be directly reached from the ligand-binding pocket (LBP) by a chain positioned on the C18 atom of an androgen steroid nucleus. Steroids 180-187 lipopolysaccharide binding protein Homo sapiens 99-120 17711855-4 2007 Using crystal structures of the hARLBD, we first found that H12 could be directly reached from the ligand-binding pocket (LBP) by a chain positioned on the C18 atom of an androgen steroid nucleus. Steroids 180-187 lipopolysaccharide binding protein Homo sapiens 122-125 17870058-11 2007 We conclude that icv administration of PYY(3-36) has a strong anorexic effect in female cynomolgus monkeys and that sensitivity to PYY(3-36) may be influenced by the ovarian steroid milieu. Steroids 174-181 peptide YY Macaca fascicularis 39-42 17870058-11 2007 We conclude that icv administration of PYY(3-36) has a strong anorexic effect in female cynomolgus monkeys and that sensitivity to PYY(3-36) may be influenced by the ovarian steroid milieu. Steroids 174-181 peptide YY Macaca fascicularis 131-134 17624763-1 2007 The human type 1 (placenta, breast tumors) and type 2 (gonads, adrenals) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) are key enzymes in steroidogenic pathways leading to the production of all active steroid hormones. Steroids 224-240 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 85-129 17624763-1 2007 The human type 1 (placenta, breast tumors) and type 2 (gonads, adrenals) isoforms of 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) are key enzymes in steroidogenic pathways leading to the production of all active steroid hormones. Steroids 224-240 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 131-140 17683928-2 2007 EG-VEGF (the gene product of PROK-1) appears to be expressed exclusively in steroid-producing organs such as the ovary, testis, adrenals and placenta. Steroids 76-83 prokineticin 1 Homo sapiens 0-7 17683928-2 2007 EG-VEGF (the gene product of PROK-1) appears to be expressed exclusively in steroid-producing organs such as the ovary, testis, adrenals and placenta. Steroids 76-83 prokineticin 1 Homo sapiens 29-35 17689071-1 2007 The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase isoenzymes 1 and 2 (HSD3B1 and HSD3B2) are membrane-bound enzymes that play essential roles in the biosynthesis of steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 87-93 17689071-2 2007 Therefore, variation in the HSD3B1 and HSD3B2 genes might play a role in the pathophysiology of steroid hormone-related disease. Steroids 96-103 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 28-34 17595317-8 2007 Furthermore, the steroid-induced tight junction sealing is attenuated in cells expressing dominant-negative forms of either Sgk or Akt, although the effect of blunting Sgk signaling was significantly greater. Steroids 17-24 serum/glucocorticoid regulated kinase 1 Homo sapiens 168-171 17709382-3 2007 Here we show that HDAC inhibitors suppressed the expression of steroidogenic gene CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes. Steroids 63-70 histone deacetylase 9 Homo sapiens 18-22 17709382-3 2007 Here we show that HDAC inhibitors suppressed the expression of steroidogenic gene CYP11A1 and decreased steroid secretion by increasing the ubiquitination and degradation of SF-1, a factor important for the transcription of all steroidogenic genes. Steroids 63-70 splicing factor 1 Homo sapiens 174-178 17579197-10 2007 CONCLUSIONS: The UGT2B7 H(268)Y polymorphism is independently associated with cortical bone size and serum sex steroid levels in young adult men. Steroids 111-118 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 17-23 17618155-0 2007 HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids. Steroids 97-105 hydroxysteroid 17-beta dehydrogenase 10 Homo sapiens 0-8 17679695-4 2007 In Drosophila, the salivary gland is sculpted by caspase-mediated programmed cell death initiated by the steroid hormone 20-hydroxyecdysone (ecdysone). Steroids 105-120 Death caspase-1 Drosophila melanogaster 49-56 17635122-4 2007 A synergistic interaction between interferon gamma and monocyte-derived mediators drives high-level astrocyte MMP-9 secretion; this and other networking effects are inhibited by steroids. Steroids 178-186 matrix metallopeptidase 9 Homo sapiens 110-115 17226781-11 2007 It is concluded that catalase has a central role in mediating rapid responses to steroid hormones. Steroids 81-97 catalase Gallus gallus 21-29 17567599-6 2007 Ablation of pituitary LH secretion and luteal steroid synthesis significantly reduced (P<0.05) EPHX2 mRNA levels in the mid-late CL, with progestin replacement being insufficient to restore its level of expression to control values. Steroids 46-53 epoxide hydrolase 2 Macaca mulatta 98-103 17631921-1 2007 One of the main functions of the translocator protein (18 kDa) or TSPO, previously known as peripheral-type benzodiazepine receptor, is the regulation of cholesterol import into mitochondria for steroid biosynthesis. Steroids 195-202 translocator protein Homo sapiens 33-53 17631921-1 2007 One of the main functions of the translocator protein (18 kDa) or TSPO, previously known as peripheral-type benzodiazepine receptor, is the regulation of cholesterol import into mitochondria for steroid biosynthesis. Steroids 195-202 translocator protein Homo sapiens 66-70 17631921-1 2007 One of the main functions of the translocator protein (18 kDa) or TSPO, previously known as peripheral-type benzodiazepine receptor, is the regulation of cholesterol import into mitochondria for steroid biosynthesis. Steroids 195-202 translocator protein Homo sapiens 92-131 17631921-9 2007 All these effects and the parallel immunocytochemical detection of TSPO in potentially steroidogenic cells (astrocytes) and non-steroidogenic cells (fibroblasts) suggest that TSPO is involved in the regulation and trafficking of intracellular cholesterol by means of mechanisms not necessarily related to steroid biosynthesis. Steroids 87-94 translocator protein Homo sapiens 67-71 17631921-9 2007 All these effects and the parallel immunocytochemical detection of TSPO in potentially steroidogenic cells (astrocytes) and non-steroidogenic cells (fibroblasts) suggest that TSPO is involved in the regulation and trafficking of intracellular cholesterol by means of mechanisms not necessarily related to steroid biosynthesis. Steroids 87-94 translocator protein Homo sapiens 175-179 17521384-3 2007 ABO-In received quadruple immunosuppression with antibody-depleting induction agents (except two), calcineurin inhibitors, antimetabolites and steroids. Steroids 143-151 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 0-3 17616271-4 2007 The approval of the new immunosuppressive agents: rabbit antithymocyte globulin, basiliximab, daclizumab, tacrolimus, mycophenolate, and sirolimus, also has facilitated the development of steroid- and calcineurin inhibitor-sparing regimens in kidney transplantation. Steroids 188-195 calcineurin binding protein 1 Homo sapiens 201-222 17897547-18 2007 In group steroid treatment, the changes of the cytokines were mainly the increase of IL-10 and IL-4, the concentration of IFN and TNF was decreased. Steroids 9-16 interleukin 4 Sus scrofa 95-99 17346682-4 2007 These results provide further evidence that circulating steroid hormones in the female rat can influence expression of a brain peptide, in this case CCK, and primarily in the limbic system, which is interesting in the context that CCK has been associated with anxiety and depression in both animals and humans. Steroids 56-63 cholecystokinin Rattus norvegicus 149-152 17346682-4 2007 These results provide further evidence that circulating steroid hormones in the female rat can influence expression of a brain peptide, in this case CCK, and primarily in the limbic system, which is interesting in the context that CCK has been associated with anxiety and depression in both animals and humans. Steroids 56-63 cholecystokinin Rattus norvegicus 231-234 17234744-8 2007 Our study suggests a different ability of IL-15-cultured NK cells to survive to steroid treatment, thus offering interesting clues for a correct NK-cell cytokine conditioning in adoptive immunotherapy. Steroids 80-87 interleukin 15 Mus musculus 42-47 17549597-2 2007 The development of new steroid intermediates and specialized library synthesis methods were required to enable the efficient preparation of structurally complex C-11 modified mifepristone analogs. Steroids 23-30 RNA polymerase III subunit K Homo sapiens 161-165 17237153-0 2007 Inhibitory effects of neurotransmitters and steroids on human CYP2A6. Steroids 44-52 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 62-68 17237153-2 2007 CYP2A6 is highly expressed in liver and, also, in brain and steroid-related tissues. Steroids 60-67 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 0-6 17237153-3 2007 In this study, we investigated the inhibitory effects of neurotransmitters and steroid hormones on CYP2A6 activity. Steroids 79-95 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 99-105 17400813-6 2007 Finally, using RT-PCR, we detected expression of genes encoding four key enzymes participating in steroids synthesis (CYP11A1, CYP11B1, CYP17 and CYP21A2) and showed transformation of progesterone into cortisol-immunoreactivity in cultured ARPE-19 cells. Steroids 98-106 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 127-134 17339378-4 2007 Loss of fkh itself is a steroid-controlled event that is mediated by the 20E-induced BR-C gene, and that renders the key death regulators hid and reaper hormone responsive. Steroids 24-31 fork head Drosophila melanogaster 8-11 17339378-5 2007 These results implicate the D. melanogaster FOXA orthologue Fkh with a novel function as a competence factor for steroid-controlled cell death. Steroids 113-120 fork head Drosophila melanogaster 60-63 17258455-0 2007 Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist. Steroids 41-49 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 63-86 17334880-1 2007 The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). Steroids 35-51 sulfotransferase family 2A member 1 Homo sapiens 95-100 17185374-0 2007 KiSS-1 messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season. Steroids 96-104 KiSS-1 metastasis suppressor Homo sapiens 0-6 17185374-8 2007 Finally, we tested the hypothesis that KiSS-1 mRNA is lower during anestrus, due to a non-steroid-dependent seasonal effect. Steroids 90-97 KiSS-1 metastasis suppressor Homo sapiens 39-45 17185374-10 2007 We conclude that KiSS-1 expression in the ARC of the ewe brain is negatively regulated by chronic levels of E and P, suggesting that both steroids may exert negative feedback control on GnRH secretion through altered kisspeptin signaling. Steroids 138-146 KiSS-1 metastasis suppressor Homo sapiens 17-23 17263731-2 2007 The human UDP-glucuronosyltransferase (UGT) isoforms UGT2B4 and UGT2B7 play a major role in the detoxification of bile acids, steroids and phenols. Steroids 126-134 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 64-70 17334929-4 2007 Expression of KiSS-1 has been localised to specific regions of the hypothalamus in many species and is regulated by gonadal steroids and across the estrous cycle. Steroids 124-132 KiSS-1 metastasis suppressor Homo sapiens 14-20 15240630-1 2004 Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS), the representative sex steroid precursors, are postulated to have antiinflammatory effects, although the molecular background remains unknown. Steroids 79-86 sulfotransferase family 2A member 1 Homo sapiens 48-53 15039143-3 2004 Aldosterone increased active K-RasA levels in A6 cells resulting in activation of downstream effectors in both the MAPK1/2 and PI3-K cascades with K-RasA directly interacting with the catalytic p110 subunit of PI3-K in a steroid-dependent manner. Steroids 221-228 mitogen-activated protein kinase 12 Cricetulus griseus 115-122 15148266-2 2004 The aim of the present study was to investigate the effect of different circulating levels of the adrenal steroid corticosterone (CORT) on locomotor hyperactivity and prepulse inhibition of acoustic startle, two behavioural animal models of aspects of schizophrenia. Steroids 106-113 cortistatin Mus musculus 130-134 15196284-8 2004 CONCLUSIONS: Our finding suggests a potential role for topical steroids in allergic rhinitis in suppressing inflammatory reactions in the nasal mucosa by regulating ICAM-1 expression on nasal epithelium. Steroids 63-71 intercellular adhesion molecule 1 Homo sapiens 165-171 15153534-5 2004 However, pure B cells incubated with IL-15 responded normally with nuclear translocation of GCR in response to steroids, but failed to translocate GCR when they were grown in the presence of CD19(-) cells. Steroids 111-119 interleukin 15 Homo sapiens 37-42 15153534-10 2004 This study demonstrates that B cells develop steroid resistance in the presence of CD56(+) cells after IL-15 stimulation. Steroids 45-52 interleukin 15 Homo sapiens 103-108 15153534-11 2004 Furthermore, IL-15 and IL-4 have the capacity to induce B cell insensitivity to steroids. Steroids 80-88 interleukin 15 Homo sapiens 13-18 15150412-4 2004 We identify a steroid modulatory domain, SMD1, on the NMDA receptor NR2B subunit that is critical for both PS enhancement and proton sensitivity. Steroids 14-21 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 41-45 15004017-1 2004 The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Steroids 51-58 ATP binding cassette subfamily C member 4 Homo sapiens 21-25 15004017-1 2004 The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Steroids 51-58 ATP binding cassette subfamily C member 4 Homo sapiens 105-109 14726441-3 2004 Using immunohistochemistry and RT-PCR, we localized the GABA-synthesizing enzyme glutamate decarboxylase 67 and the vesicular GABA transporter in steroid-producing cells of the human and rat adrenal cortex. Steroids 146-153 glutamate-ammonia ligase Rattus norvegicus 81-104 15225788-6 2004 In muscle cells, anti-VDR antisense inhibited steroid-induced Ca(2+) and Mn(2+) influx and co-immunoprecipitation of TRPC3 and VDR was observed, suggesting an association between both proteins and a functional role of the receptor in 1alpha,25(OH)(2)D(3) activation of CCE. Steroids 46-53 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 22-25 15134825-2 2004 Two key players in adrenal steroid hormone biosynthesis are the human mitochondrial cytochrome P450 enzymes CYP11B1 and CYP11B2 that catalyze the final steps in the biosynthesis of cortisol and aldosterone, respectively. Steroids 27-42 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 108-115 14701853-0 2004 Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. Steroids 60-67 klotho Homo sapiens 0-6 14701853-11 2004 Collectively, these data suggest that Klotho functions as a novel beta-glucuronidase and that steroid beta-glucuronides are potential candidates for the natural substrate(s) of Klotho. Steroids 94-101 klotho Homo sapiens 177-183 15094794-2 2004 In mature females the influence of OT on the HPA axis appeared to be dependent on ovarian steroid milieu and stress. Steroids 90-97 oxytocin/neurophysin I prepropeptide Sus scrofa 35-37 15062543-7 2004 In conclusion, we demonstrated that the CaBP-9k is distinctly regulated in the mouse placenta and extra-embryonic membrane, probably via sex steroid hormones (E2 and P4) and their receptors through a complex pathway. Steroids 141-157 prostaglandin E receptor 4 (subtype EP4) Mus musculus 159-168 14658025-4 2004 The retinol-binding protein (RBP) seems to be a useful molecular biomarker for assessing all modes of action of EDC, because it is regulated by sex steroid hormones. Steroids 148-164 SURP and G-patch domain containing 1 L homeolog Xenopus laevis 4-27 14658025-4 2004 The retinol-binding protein (RBP) seems to be a useful molecular biomarker for assessing all modes of action of EDC, because it is regulated by sex steroid hormones. Steroids 148-164 SURP and G-patch domain containing 1 L homeolog Xenopus laevis 29-32 14967219-7 2004 These results suggest that ovarian steroid hormones and IL-1beta regulate IL-15 mRNA expression and protein production in long-term culture, and that IL-1beta plays a role as a negative regulator of IL-15 production during decidualization in human endometrium. Steroids 35-42 interleukin 15 Homo sapiens 74-79 14668412-7 2004 Mutations in the steroid-regulated genes beta FTZ-F1, E93, BR-C and E74A that prevent salivary gland cell death possess altered levels and localization of filamentous Actin, alpha-Tubulin, alpha-Spectrin, nuclear Lamins and active Caspase 3. Steroids 17-24 alpha Spectrin Drosophila melanogaster 189-203 14668412-7 2004 Mutations in the steroid-regulated genes beta FTZ-F1, E93, BR-C and E74A that prevent salivary gland cell death possess altered levels and localization of filamentous Actin, alpha-Tubulin, alpha-Spectrin, nuclear Lamins and active Caspase 3. Steroids 17-24 Death executioner caspase related to Apopain/Yama Drosophila melanogaster 231-240 14695685-0 2004 Effect of gonadal steroids on progesterone receptor, estrogen receptor, and vitellogenin expression in male turtles (Chrysemys picta). Steroids 18-26 vitellogenin-2 Chrysemys picta 76-88 14694502-1 2004 A double-blinded placebo-controlled trial was performed to evaluate the use of steroid injections beneath the transverse carpal ligament in the treatment of carpal tunnel syndrome (CTS) refractory to nonsurgical therapy. Steroids 79-86 transthyretin Homo sapiens 181-184 14694502-8 2004 We conclude that although steroid injections are safe and effective for temporary relief of CTS, most patients will eventually require surgery for long-term control of their symptoms. Steroids 26-33 transthyretin Homo sapiens 92-95 15561410-9 2004 There is evidence from studies on peripheral tissues that steroid hormones regulate the expression of AQP1, AQP4 and AQP9. Steroids 58-74 aquaporin 4 Homo sapiens 108-112 14643170-2 2004 This study was performed to investigate the effectiveness of the commonly used steroids beclomethasone, budesonide and fluticasone in downregulating HASMC production of RANTES and IL-8. Steroids 79-87 C-C motif chemokine ligand 5 Homo sapiens 169-175 14993044-9 2003 Using a formulation of E2 that rapidly delivers the steroid, a necessary condition for acute therapy of an ongoing stroke, we demonstrated that 100 mg E2/kg could protect brain tissue for up to 3 h after the onset of the stroke. Steroids 52-59 cystatin 12, pseudogene Homo sapiens 151-156 12960012-15 2003 Stromal cell transit through G1 required nongenomic steroid-dependent action on signal transduction pathways that control the nuclear localization and cell type-specific expression of the D-type cyclin proteins. Steroids 52-59 proliferating cell nuclear antigen Rattus norvegicus 195-201 14636175-6 2003 The CRH-stimulated release of ACTH from AtT20 cells cultured alone was unaffected by preincubation with dexamethasone (Dex, 100 nm); by contrast, in co-cultures of AtT20 and TtT/GF cells, the steroid readily inhibited the secretory response to CRH. Steroids 192-199 corticotropin releasing hormone Mus musculus 4-7 14668092-1 2003 AIMS: Annexin 1 (ANXA1), a member of the annexin family of calcium-binding and phospholipid-binding proteins, is a key mediator of the anti-inflammatory actions of steroid hormones. Steroids 164-180 annexin A1 Homo sapiens 6-15 14668092-1 2003 AIMS: Annexin 1 (ANXA1), a member of the annexin family of calcium-binding and phospholipid-binding proteins, is a key mediator of the anti-inflammatory actions of steroid hormones. Steroids 164-180 annexin A1 Homo sapiens 17-22 14557238-2 2003 It is also not known if overload and/or anabolic steroid differentially regulate AR expression. Steroids 49-56 androgen receptor Rattus norvegicus 81-83 14622134-5 2003 Depletion of endogenous sex steroid hormones via gonadectomy (GDX) resulted in increased brain levels of Abeta in comparison to gonadally intact male rats. Steroids 28-44 amyloid beta precursor protein Rattus norvegicus 105-110 14672737-15 2003 In this regard, we found that interleukin-4 (IL-4) induced the expression of 3beta-HSD in HaCaT cells, thus allowing the cells to produce a different set of sex steroids from adrenal C19 precursors. Steroids 161-169 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 77-86 14573755-1 2003 The nuclear constitutive active receptor (CAR) is a key transcription factor regulating phenobarbital (PB)-inducible transcription of various hepatic genes that encode xenobiotic/steroid-metabolizing enzymes. Steroids 179-186 nuclear receptor subfamily 1 group I member 3 Homo sapiens 42-45 14619976-2 2003 The existence of the nuclear vitamin D receptor (VDR) has been found in numerous tissues in different organs, which are the so-called "non-classical" targets of this seco-steroid hormone. Steroids 171-186 vitamin D receptor Homo sapiens 29-47 14619976-2 2003 The existence of the nuclear vitamin D receptor (VDR) has been found in numerous tissues in different organs, which are the so-called "non-classical" targets of this seco-steroid hormone. Steroids 171-186 vitamin D receptor Homo sapiens 49-52 12843000-4 2003 High-dose steroids, bone marrow as a source of stem cells, and CD8+ count less than 50 x 10(9)/L were associated with impaired CD8+ function in the multivariable analysis. Steroids 10-18 CD8a molecule Homo sapiens 127-130 12843000-5 2003 Steroids were found to impair both CD4+ and CD8+ function in a dose-dependent manner. Steroids 0-8 CD8a molecule Homo sapiens 44-47 12969239-12 2003 The total amount of ANXA1 exported from the cells in response to the steroid was unaffected by tyrosine kinase blockade. Steroids 69-76 annexin A1 Homo sapiens 20-25 12969239-14 2003 These results suggest that (i) the ANXA1-dependent inhibitory actions of dexamethasone on the release of TSH and LH require PKC and sequences in the N-terminal domain of ANXA1, but are independent of tyrosine kinase, and (ii) while dexamethasone induces the cellular exportation of a tyrosine-phosphorylated species of ANXA1, tyrosine phosphorylation per se is not critical to the steroid-induced passage of ANXA1 across the membrane. Steroids 381-388 annexin A1 Homo sapiens 35-40 12960354-5 2003 The chemistry facilitating the increase in steroid binding capacity observed with NCX-1015 is specific, because changing the position of the NO-donating group or ubiquitous nitration by addition of an NO donor was unable to mimic this event. Steroids 43-50 T cell leukemia homeobox 2 Homo sapiens 82-85 12966351-2 2003 The Melan-A/MART-1 antigen is also expressed in Leydig cells, adrenal tissue, and steroid-secreting tumors. Steroids 82-89 melan-A Homo sapiens 4-11 12966351-2 2003 The Melan-A/MART-1 antigen is also expressed in Leydig cells, adrenal tissue, and steroid-secreting tumors. Steroids 82-89 melan-A Homo sapiens 12-18 14502490-3 2003 The evaluated SULT1A3 substrate data set consisted of 95 different substituted phenols, catechols, catecholamines, steroids, and related structures for which the K(m) values were available. Steroids 115-123 sulfotransferase family 1A member 3 Homo sapiens 14-21 14756307-6 2003 In transgenic plants transformed with CRK5 under control of the steroid-inducible promoter, expression of the transgene was induced at relatively high levels after the steroid application and this induced expression of CRK5 triggered hypersensitive response-like cell death. Steroids 64-71 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 38-42 14756307-6 2003 In transgenic plants transformed with CRK5 under control of the steroid-inducible promoter, expression of the transgene was induced at relatively high levels after the steroid application and this induced expression of CRK5 triggered hypersensitive response-like cell death. Steroids 64-71 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 219-223 14756307-6 2003 In transgenic plants transformed with CRK5 under control of the steroid-inducible promoter, expression of the transgene was induced at relatively high levels after the steroid application and this induced expression of CRK5 triggered hypersensitive response-like cell death. Steroids 168-175 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 38-42 14756307-6 2003 In transgenic plants transformed with CRK5 under control of the steroid-inducible promoter, expression of the transgene was induced at relatively high levels after the steroid application and this induced expression of CRK5 triggered hypersensitive response-like cell death. Steroids 168-175 cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Arabidopsis thaliana 219-223 12865812-3 2003 METHODS: We evaluated plasma levels and intrahepatic expression of IL-15 in 35 patients after liver transplantation, and then analyzed in vitro the influence of anticalcineurin drugs or steroids on IL-15 production and secretion. Steroids 186-194 interleukin 15 Homo sapiens 198-203 12865812-5 2003 RESULTS: Plasma levels and in situ expression of IL-15 were enhanced during liver allograft rejection, particularly during steroid-resistant acute rejection and during chronic rejection. Steroids 123-130 interleukin 15 Homo sapiens 49-54 12842524-4 2003 This study examined the association of increased release of IL-10, stimulated by steroid pretreatment, with reduced myocardial and lung injury after CPB. Steroids 81-88 interleukin 10 Homo sapiens 60-65 12842524-15 2003 Our findings demonstrate a greater release of IL-10 induced by steroid pretreatment, and better heart and lung protection after CPB. Steroids 63-70 interleukin 10 Homo sapiens 46-51 12890212-7 2003 In addition, serum levels of interferon-gamma, interleukin (IL)-6, IL-5 and eosinophil cationic protein, which were increased on admission, decreased dramatically after steroid therapy. Steroids 169-176 ribonuclease A family member 3 Homo sapiens 76-103 12767051-11 2003 In consideration of RA-differentiation therapy, it may be of pathophysiological relevance that the antineoplastic agents potentiate RA-induced, steroid-sensitive, induction of LTC(4) S in RBL-1 cells. Steroids 144-151 leukotriene C4 synthase Rattus norvegicus 176-184 12967785-0 2003 Generation of antigen-specific, interleukin-10-producing T-cells using dendritic cell stimulation and steroid hormone conditioning. Steroids 102-117 interleukin 10 Homo sapiens 32-46 12967785-6 2003 When a co-stimulation-deficient population of DCs was employed for the in vitro, steroid hormone-conditioned stimulations, two additional effects were observed: (a) a further skewing towards antigen-specific IL-10 production and (b) enhanced activation-induced up-regulation of the inhibitory receptor CTLA-4 (CD152). Steroids 81-96 interleukin 10 Homo sapiens 208-213 12799447-1 2003 The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Steroids 91-98 nuclear receptor subfamily 1 group I member 3 Homo sapiens 21-24 12799447-1 2003 The nuclear receptor CAR (NR1I3) regulates transcription of genes encoding xenobiotic- and steroid-metabolizing enzymes. Steroids 91-98 nuclear receptor subfamily 1 group I member 3 Homo sapiens 26-31 12899789-11 2003 And large dosage of steroid may inhibit the level of CD(4)(+) and CD8 (P < 0.05). Steroids 20-27 CD8a molecule Homo sapiens 66-69 12790800-13 2003 Increasing the CYP17 to HSD3B2 ratio is likely to promote the use of steroid precursors for the production of DHEA(S) and not for cortisol. Steroids 69-76 sulfotransferase family 2A member 1 Homo sapiens 110-117 12943710-6 2003 The X-ray crystal structures of AKR1C9 and AKR1C2 (human type 3 3alpha-HSD, bile acid binding protein and peripheral 3alpha-HSD) reveal that the AKR1C2 structure can bind steroids backwards (D-ring in the A-ring position) and upside down (beta-face inverted) relative to the position of a 3-ketosteroid in AKR1C9 and this may account for its functional plasticity. Steroids 171-179 aldo-keto reductase family 1, member C14 Rattus norvegicus 32-38 12943710-6 2003 The X-ray crystal structures of AKR1C9 and AKR1C2 (human type 3 3alpha-HSD, bile acid binding protein and peripheral 3alpha-HSD) reveal that the AKR1C2 structure can bind steroids backwards (D-ring in the A-ring position) and upside down (beta-face inverted) relative to the position of a 3-ketosteroid in AKR1C9 and this may account for its functional plasticity. Steroids 171-179 aldo-keto reductase family 1 member C4 Homo sapiens 64-74 12943710-6 2003 The X-ray crystal structures of AKR1C9 and AKR1C2 (human type 3 3alpha-HSD, bile acid binding protein and peripheral 3alpha-HSD) reveal that the AKR1C2 structure can bind steroids backwards (D-ring in the A-ring position) and upside down (beta-face inverted) relative to the position of a 3-ketosteroid in AKR1C9 and this may account for its functional plasticity. Steroids 171-179 aldo-keto reductase family 1 member C4 Homo sapiens 117-127 12943710-6 2003 The X-ray crystal structures of AKR1C9 and AKR1C2 (human type 3 3alpha-HSD, bile acid binding protein and peripheral 3alpha-HSD) reveal that the AKR1C2 structure can bind steroids backwards (D-ring in the A-ring position) and upside down (beta-face inverted) relative to the position of a 3-ketosteroid in AKR1C9 and this may account for its functional plasticity. Steroids 171-179 aldo-keto reductase family 1, member C14 Rattus norvegicus 306-312 12767484-1 2003 Focusing on the hippocampal CA1 region, effects of peripheral gonadal and adrenal steroids on the glucocorticoid receptor (GR) were immunohistochemically evaluated in male and female adult rat brains after adrenalectomy (ADX), gonadectomy (GDX), and administration of estradiol (E2) and/or corticosterone (CS). Steroids 82-90 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 98-121 12767484-1 2003 Focusing on the hippocampal CA1 region, effects of peripheral gonadal and adrenal steroids on the glucocorticoid receptor (GR) were immunohistochemically evaluated in male and female adult rat brains after adrenalectomy (ADX), gonadectomy (GDX), and administration of estradiol (E2) and/or corticosterone (CS). Steroids 82-90 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 123-125 12756265-1 2003 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Steroids 90-105 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 4-38 12756265-1 2003 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Steroids 90-105 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 40-49 12756265-2 2003 Vaccinia virus (VV) also synthesizes steroid hormones with a 3beta-HSD enzyme (v3beta-HSD) encoded by gene A44L. Steroids 37-53 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 61-70 12756265-2 2003 Vaccinia virus (VV) also synthesizes steroid hormones with a 3beta-HSD enzyme (v3beta-HSD) encoded by gene A44L. Steroids 37-53 hydroxysteroid dehydrogenase Vaccinia virus 107-111 12723952-2 2003 We have previously shown with 16alpha-substituted analogues of estradiol that carboxylates proximal to the steroid ring neither bind to the estrogen receptor nor activate estrogen-responsive genes. Steroids 107-114 ATPase H+ transporting accessory protein 1 Homo sapiens 30-37 12672016-0 2003 Effects of neonatal gonadal steroids on adult CA3 pyramidal neuron dendritic morphology and spatial memory in rats. Steroids 28-36 carbonic anhydrase 3 Rattus norvegicus 46-49 12798356-1 2003 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) is a crucial steroidogenic enzyme which catalyzes an essential step in the biosynthesis of all classes of steroid hormones. Steroids 181-197 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 64-73 12770750-10 2003 CONCLUSIONS: It is suggested from the present study that LDLR may play an essential role in uptake of exogenous LDL into blastocyst stage and cholesterol derived from LDL may be the source of steroid hormone synthesis. Steroids 192-207 low density lipoprotein receptor Mus musculus 57-61 12523936-0 2003 Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Steroids 0-7 ATP binding cassette subfamily C member 4 Homo sapiens 57-93 12523936-3 2003 Since MRP4, like MRP1-3, also mediates transport of a model steroid conjugate substrate, oestradiol 17-beta-D-glucuronide (E(2)17betaG), we tested whether MRP4 may be involved in the transport of steroid and bile acid conjugates. Steroids 60-67 ATP binding cassette subfamily C member 4 Homo sapiens 6-10 12560326-10 2003 These data suggest that neuroactive steroid effects on the GABA(A) receptor may be mediated by binding to an accessory protein, VDAC-1. Steroids 36-43 voltage-dependent anion channel 1 Rattus norvegicus 128-134 12639897-3 2003 Exposure of PDFS cells to dexamethasone caused time-dependent increases in the expression of ANXA1 mRNA and protein, which were first detected within 2 h of steroid contact. Steroids 157-164 annexin A1 Homo sapiens 93-98 12639897-7 2003 In addition, blockade of phosphatidylinositiol 3-kinase (wortmannin) or MAPK pathways with PD 98059 or UO 126 (selective for MAPK kinse 1 and 2) prevented the steroid-induced translocation of Ser-P-ANXA1 to the cell surface. Steroids 159-166 annexin A1 Homo sapiens 192-203 12642469-5 2003 On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 221-227 12677569-8 2003 CONCLUSIONS: c-jun, ODC, and proglucagon may be involved in the adaptive response that occurs with steroids and variations in dietary lipids after intestinal resection. Steroids 99-107 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 12644700-0 2003 Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor. Steroids 11-18 nuclear receptor subfamily 1 group I member 3 Homo sapiens 87-119 12644700-1 2003 Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. Steroids 237-245 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 59-89 12644700-1 2003 Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products function as the principal means to eliminate a vast array of steroids, heme metabolites, environmental toxins, and drugs. Steroids 237-245 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 91-95 12787894-9 2003 Met-639 participates in hydrophobic interactions mainly with GC side chains, while Asn-564 forms a hydrogen bond to the C11-OH group of the steroid. Steroids 140-147 RNA polymerase III subunit K Homo sapiens 120-123 12646371-1 2003 Adrenodoxin reductase (AR) and adrenodoxin (Adx) are components of the mammalian mitochondrial steroid-hydroxylating system. Steroids 95-102 ferredoxin 1 Homo sapiens 44-47 14586159-3 2003 Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S) are neuroactive steroids with effects on several neurophysiological and behavioral processes. Steroids 77-85 sulfotransferase family 2A member 1 Homo sapiens 53-59 12763073-0 2003 The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Steroids 24-31 5-hydroxytryptamine receptor 1B Rattus norvegicus 94-99 12921694-0 2003 Effect of ovarian steroids on basal and oxytocin-induced prostaglandin F2alpha secretion from pig endometrial cells. Steroids 18-26 oxytocin/neurophysin I prepropeptide Sus scrofa 40-48 12433804-3 2002 Etonitazenyl, a mu opioid receptor antagonist, was found to inhibit competitively opioid, steroid, and other substrate glucuronidation reactions catalyzed by UGT2B7. Steroids 90-97 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 158-164 12617804-1 2002 Cyp11a1 (P450scc, cholesterol side-chain cleavage enzyme) is the first enzyme for the synthesis of all steroid hormones. Steroids 103-119 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 0-7 12617804-1 2002 Cyp11a1 (P450scc, cholesterol side-chain cleavage enzyme) is the first enzyme for the synthesis of all steroid hormones. Steroids 103-119 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 9-16 12807155-11 2002 This suggests that one of the reasons for the poor prognosis of bcr-abl positive ALL could be a lower steroid sensitivity. Steroids 102-109 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 64-71 12454095-6 2002 The RGD-CAP mRNA level decreased in cultured PDL cells exposed to 10(-8) M dexamethasone or 10(-8) M 1alpha,25-dihydroxyvitamin D(3) when these steroids increased alkaline phosphatase (ALP) activity. Steroids 144-152 transforming growth factor beta induced Homo sapiens 4-11 12516962-6 2002 A class of steroids related to the cardiac glycosides was identified that potently inhibited the plasma membrane Na(+)K(+)-ATPase resulting in the inhibition of four of the prostate target genes including transcription factors Hoxb-13, hPSE/PDEF, hepatocyte nuclear factor-3alpha, and the inhibitor of apoptosis, survivin. Steroids 11-19 homeobox B13 Homo sapiens 227-234 12516962-6 2002 A class of steroids related to the cardiac glycosides was identified that potently inhibited the plasma membrane Na(+)K(+)-ATPase resulting in the inhibition of four of the prostate target genes including transcription factors Hoxb-13, hPSE/PDEF, hepatocyte nuclear factor-3alpha, and the inhibitor of apoptosis, survivin. Steroids 11-19 SAM pointed domain containing ETS transcription factor Homo sapiens 241-245 12472684-0 2002 Mutation in domain II of IAA1 confers diverse auxin-related phenotypes and represses auxin-activated expression of Aux/IAA genes in steroid regulator-inducible system. Steroids 132-139 indole-3-acetic acid inducible Arabidopsis thaliana 25-29 12472684-5 2002 We used a steroid hormone-inducible system to reveal putative roles and downstream signaling of IAA1 in auxin response. Steroids 10-25 indole-3-acetic acid inducible Arabidopsis thaliana 96-100 12416991-7 2002 Two-substrate kinetic analysis and dead-end inhibition studies for 5alpha-DHP reduction and allopregnanolone oxidation indicated that 3alpha-HSD type III utilized a ternary complex (sequential) kinetic mechanism, with nicotinamide adenine dinucleotide cofactor binding before steroid substrate and leaving after steroid product. Steroids 276-283 aldo-keto reductase family 1 member C4 Homo sapiens 134-144 12416991-7 2002 Two-substrate kinetic analysis and dead-end inhibition studies for 5alpha-DHP reduction and allopregnanolone oxidation indicated that 3alpha-HSD type III utilized a ternary complex (sequential) kinetic mechanism, with nicotinamide adenine dinucleotide cofactor binding before steroid substrate and leaving after steroid product. Steroids 312-319 aldo-keto reductase family 1 member C4 Homo sapiens 134-144 12530651-7 2002 Thus, H156 in WT 1 vs. Y156 in WT 2 accounts for the substantially higher affinity of WT 1 3beta-HSD activity for these substrate and inhibitor steroids relative to the WT 2 enzyme. Steroids 144-152 multiple tumor-associated chromosome region 1 Homo sapiens 31-35 12530651-7 2002 Thus, H156 in WT 1 vs. Y156 in WT 2 accounts for the substantially higher affinity of WT 1 3beta-HSD activity for these substrate and inhibitor steroids relative to the WT 2 enzyme. Steroids 144-152 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 91-100 12530651-7 2002 Thus, H156 in WT 1 vs. Y156 in WT 2 accounts for the substantially higher affinity of WT 1 3beta-HSD activity for these substrate and inhibitor steroids relative to the WT 2 enzyme. Steroids 144-152 multiple tumor-associated chromosome region 1 Homo sapiens 169-173 12469945-9 2002 Since only the steroid preparation was shown to down-regulate the intracellular release of IL-12, it is tempting to assume that steroid addition in immunosuppressive schemes is beneficial for the suppression of Th1-inducing cytokine production, as well as for the compensation of possible up-regulation induced by other immunosuppressive agents administered concurrently. Steroids 15-22 negative elongation factor complex member C/D Homo sapiens 211-214 12469945-9 2002 Since only the steroid preparation was shown to down-regulate the intracellular release of IL-12, it is tempting to assume that steroid addition in immunosuppressive schemes is beneficial for the suppression of Th1-inducing cytokine production, as well as for the compensation of possible up-regulation induced by other immunosuppressive agents administered concurrently. Steroids 128-135 negative elongation factor complex member C/D Homo sapiens 211-214 12388644-0 2002 Identification of a peptide antagonist to the peripheral-type benzodiazepine receptor that inhibits hormone-stimulated leydig cell steroid formation. Steroids 131-138 translocator protein Homo sapiens 46-85 12388644-1 2002 Peripheral-type benzodiazepine receptor (PBR) is an 18-kDa high-affinity cholesterol and drug ligand-binding protein involved in various cell functions, including cholesterol transport and steroid biosynthesis. Steroids 189-196 translocator protein Homo sapiens 0-39 12388644-1 2002 Peripheral-type benzodiazepine receptor (PBR) is an 18-kDa high-affinity cholesterol and drug ligand-binding protein involved in various cell functions, including cholesterol transport and steroid biosynthesis. Steroids 189-196 translocator protein Homo sapiens 41-44 12589934-12 2002 Thus, this paper provides insight into the mechanisms of glucocorticoid transport in cells and demonstrates a diversity of two independent mechanisms of transport of glucocorticoids by Abcb1a/Abcb1b and Abcc1a with individual patterns of steroid specificity. Steroids 238-245 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 203-209 12410800-1 2002 Regulation of acute-phase serum amyloid A (A-SAA) synthesis by proinflammatory cytokines and steroid hormones in human aortic smooth muscle cells (HASMCs) is distinct from that in HepG2 cells. Steroids 93-109 serum amyloid A1 cluster Homo sapiens 45-48 12093364-0 2002 Ance, a Drosophila angiotensin-converting enzyme homologue, is expressed in imaginal cells during metamorphosis and is regulated by the steroid, 20-hydroxyecdysone. Steroids 136-143 Angiotensin converting enzyme Drosophila melanogaster 0-4 12093808-1 2002 A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 183-190 heat shock protein family A (Hsp70) member 4 Homo sapiens 51-56 12093808-1 2002 A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 218-225 heat shock protein family A (Hsp70) member 4 Homo sapiens 51-56 12193384-3 2002 We have recently demonstrated potent inhibition by IGFBP-4 of both theca and granulosa cell steroid production. Steroids 92-99 insulin like growth factor binding protein 4 Homo sapiens 51-58 12429139-4 2002 One potential target of glucocorticoid action in the adrenal is an enzyme critical for adrenocortical steroid production: 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD). Steroids 102-109 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 163-180 12429139-4 2002 One potential target of glucocorticoid action in the adrenal is an enzyme critical for adrenocortical steroid production: 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD). Steroids 102-109 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 182-191 12425955-9 2002 The present study showed an inverse correlation of lymphocyte changes with the plasma levels of steroids, especially DHEA and its metabolite, DHEAS. Steroids 96-104 sulfotransferase family 2A member 1 Homo sapiens 142-147 12130580-1 2002 Estrogen sulfotransferase (EST) catalyzes the sulfoconjugation and inactivation of the steroid hormone estrogen. Steroids 87-102 sulfotransferase family 1E, member 1 Mus musculus 0-25 12130580-1 2002 Estrogen sulfotransferase (EST) catalyzes the sulfoconjugation and inactivation of the steroid hormone estrogen. Steroids 87-102 sulfotransferase family 1E, member 1 Mus musculus 27-30 12100060-0 2002 Accuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthma. Steroids 67-74 ribonuclease A family member 3 Homo sapiens 28-55 12113888-1 2002 Cyclosporine A and steroids are effective against rheumatoid arthritis and also known as substrates of P-glycoprotein (P-gp). Steroids 19-27 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 103-117 12113888-1 2002 Cyclosporine A and steroids are effective against rheumatoid arthritis and also known as substrates of P-glycoprotein (P-gp). Steroids 19-27 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 119-123 12023539-1 2002 In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand, 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575), in models of central and peripheral neurodegeneration in vivo and its effect on steroid concentrations in plasma and nervous tissue. Steroids 329-336 translocator protein Rattus norvegicus 132-135 12067750-7 2002 The results indicate that nNOS mRNA expression in the rPOA is sexually dimorphic and regulated by ovarian steroids in a sex specific manner. Steroids 106-114 nitric oxide synthase 1 Rattus norvegicus 26-30 12168835-2 2002 Here we present the first report on the modulational effects of the steroids 17beta-estradiol (E2) and 17alpha-ethinylestradiol (EE2) on oncogene MDM2 in human hepatocytes. Steroids 68-76 MDM2 proto-oncogene Homo sapiens 146-150 12168835-4 2002 RESULTS: The hepatocytes responded to stimulation with steroid E2/EE2 concentrations from 1-100 nmol/l with the overexpression of MDM2 protein while non-stimulated cells were negative. Steroids 55-62 MDM2 proto-oncogene Homo sapiens 130-134 12168835-8 2002 CONCLUSION: The data show that steroid hormones are involved in the induction of MDM2 alterations in benign human hepatocytes. Steroids 31-47 MDM2 proto-oncogene Homo sapiens 81-85 11997213-0 2002 Regulation of androgen receptor mRNA expression in primary culture of Harderian gland cells: cross-talk between steroid hormones. Steroids 112-119 androgen receptor Mesocricetus auratus 14-31 11997213-6 2002 Since these steroids differently modulate AR expression, our results must be considered in the context of multi-hormonal control of gene expression that could act through cross-talk between members of the steroid-thyroid hormones. Steroids 12-20 androgen receptor Mesocricetus auratus 42-44 11997213-6 2002 Since these steroids differently modulate AR expression, our results must be considered in the context of multi-hormonal control of gene expression that could act through cross-talk between members of the steroid-thyroid hormones. Steroids 12-19 androgen receptor Mesocricetus auratus 42-44 12000543-10 2002 This is the first report to link mechanisms of steroid negative feedback with tenia tecta GnRH neurones, providing a new focus for investigating brain region-specific steroidal regulation of GnRH synthesis. Steroids 47-54 progonadoliberin-1 Mesocricetus auratus 90-94 12015155-2 2002 Like steroid hormones, 1,25(OH)2D3 is efficacious at very low concentrations and serves as a ligand for vitamin D receptors (VDR), associating with VDR very high affinity. Steroids 5-21 vitamin D receptor Homo sapiens 104-123 12015155-2 2002 Like steroid hormones, 1,25(OH)2D3 is efficacious at very low concentrations and serves as a ligand for vitamin D receptors (VDR), associating with VDR very high affinity. Steroids 5-21 vitamin D receptor Homo sapiens 125-128 11960621-1 2002 The steroid hormone 1 alpha,25(OH)(2)-vitamin D(3) [1 alpha,25(OH)(2)D(3)] mediates through its widely distributed nuclear receptor (VDR(nuc)) regulation of gene transcription (genomic responses) and through a putative membrane receptor (VDR(mem)) a variety of rapid responses. Steroids 4-19 vitamin D receptor Homo sapiens 133-136 11960621-1 2002 The steroid hormone 1 alpha,25(OH)(2)-vitamin D(3) [1 alpha,25(OH)(2)D(3)] mediates through its widely distributed nuclear receptor (VDR(nuc)) regulation of gene transcription (genomic responses) and through a putative membrane receptor (VDR(mem)) a variety of rapid responses. Steroids 4-19 vitamin D receptor Homo sapiens 238-241 11935401-0 2002 Steroid effects on secretion from subsets of lactotrophs: role of folliculo-stellate cells and annexin 1. Steroids 0-7 annexin A1 Homo sapiens 95-104 11983494-1 2002 The C21 steroids, progesterone and 20 alpha-hydroxy-4-pregnen-3-one (20 alpha-DHP) play pivotal roles in the initiation, timing and maintenance of ovulatory function and pregnancy in female mammals. Steroids 8-16 dihydropyrimidinase Rattus norvegicus 78-81 11869873-1 2002 The formation of steroids in the H295R human adrenocortical carcinoma cell line was analysed by HPLC or RIA, and based on these data the apparent catalytic activities of CYP11A, CYP17, CYP21 and CYP11B1 in this cell line were calculated. Steroids 17-25 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 195-202 12068200-8 2002 However, according to the relationship between the platelet activating factor acetylhydrolase gene mutation and clinical characteristics of ulcerative colitis patients, the operative ratio cause of unresponsiveness to steroid therapy was significantly higher in patients with the GT genotype than in those with the GG genotype (66.7 vs. 27.6 percent, P = 0.019). Steroids 218-225 phospholipase A2 group VII Homo sapiens 51-93 12068200-9 2002 CONCLUSION: We conclude that steroid-nonresponsive ulcerative colitis patients have a high frequency of the platelet activating factor acetylhydrolase gene mutation. Steroids 29-36 phospholipase A2 group VII Homo sapiens 108-150 11811958-3 2002 Earlier studies from our laboratory (1) linked TSC2 with steroid/nuclear receptor signaling. Steroids 57-64 TSC complex subunit 2 Homo sapiens 47-51 11811958-9 2002 Deletion mutagenesis studies further suggested that this CaM binding domain is required for tuberin modulation of steroid receptor function and that mutations in this region may be involved in the pathology of TSC and LAM. Steroids 114-121 TSC complex subunit 2 Homo sapiens 92-99 11876781-10 2002 The increased Fos expression in these limbic brain regions is of particular interest in relation to the behavioural changes reported in humans who abuse anabolic androgenic steroids and the abuse potential of these drugs. Steroids 173-181 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 14-17 11795941-0 2002 Transforming growth factor-alpha abrogates the glucocorticoid stimulation of tight junction formation and reverses the steroid-induced down-regulation of fascin in rat mammary epithelial tumor cells by a Ras-dependent pathway. Steroids 119-126 transforming growth factor alpha Rattus norvegicus 0-32 11796656-2 2002 We tested the overall hypothesis that circulating gonadal steroids determine the gender differences in morphine- and MK-801-induced behavior and c-Fos expression. Steroids 58-66 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 145-150 11739103-1 2002 Glutamine synthetase, a key enzyme in the production of glutamine, is known to be induced by glucocorticoids and preserved in skeletal muscle during aging, but the effect of other steroids, such as sex steroids (progesterone, estradiol), is unknown in vivo. Steroids 180-188 glutamate-ammonia ligase Rattus norvegicus 0-20 12593785-0 2002 Steroid and antihistamines modulate RANTES release in cultured peripheral blood mononuclear cells of atopic patients. Steroids 0-7 C-C motif chemokine ligand 5 Homo sapiens 36-42 12593785-9 2002 RANTES release significantly decreased in supernatants of all cell cultures from steroid (p&#x003C;0.01) and antihistamine (p=0.03 and 0.04) groups after treatments, compared to the basal values; whereas it increased slightly in controls. Steroids 81-88 C-C motif chemokine ligand 5 Homo sapiens 0-6 12593785-10 2002 Co-variance analysis on RANTES levels, adjusting for pre-treatment values, showed a significant reduction of RANTES release by PHA-stimulated PBMCs from steroid (p=0.003) and anti-histamine (p=0.03) groups, with respect to the placebo group. Steroids 153-160 C-C motif chemokine ligand 5 Homo sapiens 24-30 12593785-10 2002 Co-variance analysis on RANTES levels, adjusting for pre-treatment values, showed a significant reduction of RANTES release by PHA-stimulated PBMCs from steroid (p=0.003) and anti-histamine (p=0.03) groups, with respect to the placebo group. Steroids 153-160 C-C motif chemokine ligand 5 Homo sapiens 109-115 12593785-11 2002 The same statistical tool applied between the steroid and the antihistamine groups showed, after therapy, the lowest levels of RANTES to be associated with steroid treatment (p=0.005). Steroids 46-53 C-C motif chemokine ligand 5 Homo sapiens 127-133 12593785-11 2002 The same statistical tool applied between the steroid and the antihistamine groups showed, after therapy, the lowest levels of RANTES to be associated with steroid treatment (p=0.005). Steroids 156-163 C-C motif chemokine ligand 5 Homo sapiens 127-133 12593785-12 2002 The study shows that the steroid is the most effective drug in modulating RANTES release from PBMCs. Steroids 25-32 C-C motif chemokine ligand 5 Homo sapiens 74-80 11773026-11 2002 The interactions with the Hep II domain of fibronectin could alter cell-matrix interactions in the TM and provides an interesting lead to explore the role(s) of TIGR/MYOC in both steroid-induced and primary open angle glaucoma. Steroids 179-186 DNL-type zinc finger Homo sapiens 26-29 11825061-0 2002 Granulin precursor gene: a sex steroid-inducible gene involved in sexual differentiation of the rat brain. Steroids 31-38 granulin precursor Rattus norvegicus 0-8 11825061-13 2002 The present results suggest that the grn gene, the expression of which is induced by sex steroids in the neonatal hypothalamus, plays a crucial role in the functional masculinization of the rat brain. Steroids 89-97 granulin precursor Rattus norvegicus 37-40 12436949-2 2002 The release of oxytocin and vasopressin to plasma is under influence of ovarian steroids. Steroids 80-88 oxytocin/neurophysin I prepropeptide Homo sapiens 15-23 11718752-5 2001 Steroid pulse therapy and immunoadsorption therapy alleviated the clinical symptoms and decreased the anti-GAD antibody titer. Steroids 0-7 glutamate decarboxylase 1 Homo sapiens 107-110 11747826-0 2001 Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Steroids 84-91 coactivator associated arginine methyltransferase 1 Homo sapiens 19-24 11733402-0 2001 Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor. Steroids 4-12 coagulation factor II (thrombin) receptor Rattus norvegicus 92-109 11733402-0 2001 Sex steroids used in hormonal treatment increase vascular procoagulant activity by inducing thrombin receptor (PAR-1) expression: role of the glucocorticoid receptor. Steroids 4-12 coagulation factor II (thrombin) receptor Rattus norvegicus 111-116 11720902-0 2001 Expression of BRCA1 gene in ewe mammary epithelial cells during pregnancy: regulation by growth hormone and steroid hormones. Steroids 108-124 BRCA1 DNA repair associated Homo sapiens 14-19 11720902-7 2001 CONCLUSIONS: These results suggest that BRCA1 is a potential regulator of the effects of steroid hormones and growth hormone in the induction of mammary epithelial cell proliferation. Steroids 89-105 BRCA1 DNA repair associated Homo sapiens 40-45 11726286-0 2001 Gonadotropin-dependent expression of sterol 14-demethylase P450 (CYP51) in rat ovaries and its contribution to the production of a meiosis-activating steroid. Steroids 150-157 cytochrome P450, family 51 Rattus norvegicus 65-70 11726286-6 2001 Sterol analysis indicated that the product of the CYP51-mediated lanosterol 14-demethylation, 4,4-dimethylcholesta-8,14,24-trienol, which has been identified as a meiosis-activating steroid (MAS) in mammals [Byskov et al. Steroids 182-189 cytochrome P450, family 51 Rattus norvegicus 50-55 11689696-1 2001 We have previously demonstrated that overexpression of Cdc25B in transgenic mice resulted in mammary gland hyperplasia and increased steroid hormone responsiveness. Steroids 133-148 cell division cycle 25B Mus musculus 55-61 12055703-6 2001 CONCLUSIONS: The results suggest that the plasma levels of DHEA-S and ASD (adrenal C19 steroid hormones) correlate with the plasma lipid profiles of healthy men. Steroids 87-103 sulfotransferase family 2A member 1 Homo sapiens 59-65 17131419-1 2007 Neurotrophic factors and steroid hormones have been shown to have neuroprotective/neurotherapeutic effects, and it has been shown previously that brain-derived neurotrophic factor (BDNF) and testosterone have a combinatorial effect in the maintenance of motoneurons. Steroids 25-32 brain derived neurotrophic factor Homo sapiens 181-185 17208360-4 2007 Marked defects in steroid production are observed in adrenal cells from HSL knockout mice, due to an inability to process and utilize cholesteryl esters selectively derived from lipoproteins. Steroids 18-25 lipase, hormone sensitive Mus musculus 72-75 17914260-2 2007 Vitamin D is a fat-soluble steroid hormone that interacts with its nuclear receptor (VDR) to regulate a variety of biological processes, such as bone metabolism, immune response modulation and transcription of several genes involved in CKD and PD disease mechanisms. Steroids 27-42 vitamin D receptor Homo sapiens 85-88 17211152-9 2007 The results demonstrate that NPHS1 and NPHS2 mutations are also present in Chinese sporadic NS patients, suggesting that genetic changes of nephrin and podocin may play pathogenetic roles in some patients with sporadic steroid resistant NS. Steroids 219-226 NPHS1 adhesion molecule, nephrin Homo sapiens 29-34 17211152-9 2007 The results demonstrate that NPHS1 and NPHS2 mutations are also present in Chinese sporadic NS patients, suggesting that genetic changes of nephrin and podocin may play pathogenetic roles in some patients with sporadic steroid resistant NS. Steroids 219-226 NPHS1 adhesion molecule, nephrin Homo sapiens 140-147 17211154-6 2007 The clinical study showed that renal beta2-AR expression gradually increased with age and was up-regulated by steroid therapy. Steroids 110-117 adrenoceptor beta 2 Homo sapiens 37-45 17211154-8 2007 This may have important implications for the use of beta2-AR agonists in the treatment of sick children with, for example, steroid therapy or endotoxemia. Steroids 123-130 adrenoceptor beta 2 Homo sapiens 52-60 17161352-11 2006 The success rate of steroid withdrawal 12 months after transplantation in recipients of ABO-compatible grafts was significantly higher than that in recipients of ABO-incompatible grafts (66% vs. 44%). Steroids 20-27 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 88-91 11860455-7 2001 Changes in B-50 and GFAP staining were observed in the steroid-treated and depressed patients in areas CA1 and CA2 only. Steroids 55-62 glial fibrillary acidic protein Homo sapiens 20-24 11860455-7 2001 Changes in B-50 and GFAP staining were observed in the steroid-treated and depressed patients in areas CA1 and CA2 only. Steroids 55-62 carbonic anhydrase 1 Homo sapiens 103-106 11860455-7 2001 Changes in B-50 and GFAP staining were observed in the steroid-treated and depressed patients in areas CA1 and CA2 only. Steroids 55-62 carbonic anhydrase 2 Homo sapiens 111-114 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 217-224 interleukin 17A Homo sapiens 10-16 35346673-13 2022 Moreover, IL-17A-induced pyroptosis contributes to steroid resistance by affecting glucocorticoid receptor (GR)alpha and GRbeta expression, and the inhibition of pyroptotic proteins partially abolished IL-17A-induced steroid resistance in hNECs. Steroids 217-224 interleukin 17A Homo sapiens 202-208 11701720-2 2001 Because the pituitary hormone ACTH, via activation of the cAMP pathway, regulates both cell proliferation/differentiation and steroid synthesis in the adrenal cortex, in this study we focused on the cAMP-dependent transcription factors cAMP responsive element modulator (CREM) and cAMP responsive element binding protein (CREB). Steroids 126-133 cAMP responsive element modulator Homo sapiens 236-269 35085884-9 2022 For steroidogenesis, alpha/beta-TBCO, PBEB, and EHTBB all upregulated genes encoding for steroid synthesis enzymes, including 17betaHSD, CYP11B1 and CYP17. Steroids 89-96 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 137-144 11691658-16 2001 These results indicate that in different endocrine steroid-secreting cells P450(scc), 3 beta-HSD and P450(c17) have the same association with cytoplasmic organelles (with the exception of 3 beta-HSD in Leydig cells), suggesting similar intracellular pathways for biosynthesis of steroid hormones. Steroids 51-58 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 80-83 11691658-16 2001 These results indicate that in different endocrine steroid-secreting cells P450(scc), 3 beta-HSD and P450(c17) have the same association with cytoplasmic organelles (with the exception of 3 beta-HSD in Leydig cells), suggesting similar intracellular pathways for biosynthesis of steroid hormones. Steroids 279-286 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 80-83 17056005-1 2006 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Steroids 90-105 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 4-38 17056005-1 2006 The 3beta-hydroxysteroid dehydrogenase (3beta-HSD) isoenzymes play a key role in cellular steroid hormone synthesis. Steroids 90-105 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 40-49 11711910-4 2001 The authors recently demonstrated up-regulation of the mitochondrial cytochrome b gene in hemangioma associated with steroid-induced regression. Steroids 117-124 mitochondrially encoded cytochrome b Homo sapiens 69-81 35293350-7 2022 Patients carrying AG genotype (rs2275913, IL-17A) had a significantly higher risk of steroid-dependent response (69.1% of SD VS 46.4% of SS; OR=2.58, p=0.014). Steroids 85-92 interleukin 17A Homo sapiens 42-48 11711910-11 2001 The authors concluded that mitochondrial cytochrome b is associated with both the spontaneous and the steroid-induced regression of hemangioma, probably by regulating apoptosis. Steroids 102-109 mitochondrially encoded cytochrome b Homo sapiens 41-53 17192583-5 2006 Evidence is presented that ANXA1 plays a critical role in effecting the negative feedback effects of GCs on the release of corticotrophin (ACTH) and its hypothalamic-releasing hormones and that it is particularly pertinent to the early-onset actions of the steroids that are mediated via a nongenomic mechanism. Steroids 257-265 annexin A1 Homo sapiens 27-32 16887917-1 2006 Steroidogenic factor (SF1, Ad4BP, NR5A1) is a nuclear receptor that is essential for steroid hormone biosynthesis and endocrine development. Steroids 85-100 splicing factor 1 Homo sapiens 22-25 11673207-10 2001 CD4/CD8 values correlated positively with lymphocyte counts but negatively with time elapsed between last MTX administration and BAL and with steroid cumulative dose received by the patients. Steroids 142-149 CD8a molecule Homo sapiens 4-7 35293350-8 2022 Similarly, patients carrying A allele of IL-10-rs1800872 (39.0% of SD VS 26.7% of SS; OR=1.76, p=0.018) and C allele of IL-10-rs1800896 (12.3% of SD VS 3.9% of SS; OR=3.44, p=0.004) had a higher risk of steroid-dependent response. Steroids 203-210 interleukin 10 Homo sapiens 120-125 11673207-12 2001 The between-patient variation in CD4/CD8 T-cell ratios may reflect the large range of time intervals between last MTX administration and BAL evaluation and the use of adjunctive steroid therapy. Steroids 178-185 CD8a molecule Homo sapiens 37-40 35280986-8 2022 Within these pathways, signal-transducer-and-activator-of-transcription-1 (STAT1) protein was identified as the most significantly changed protein contributing to the pathogenesis of exacerbation and the underlying steroid resistance based on the label-free quantification; and this was further confirmed by both Parallel Reaction Monitoring (PRM) proteomics assay and western blots. Steroids 215-222 signal transducer and activator of transcription 1 Mus musculus 23-73 11584395-10 2001 ANP or drugs such as steroids, which raise endogenous ANP levels, may have a therapeutic application in CDH complicated by PPH. Steroids 21-29 natriuretic peptide A Rattus norvegicus 0-3 11584395-10 2001 ANP or drugs such as steroids, which raise endogenous ANP levels, may have a therapeutic application in CDH complicated by PPH. Steroids 21-29 natriuretic peptide A Rattus norvegicus 54-57 16837735-4 2006 Our present studies were carried out to examine the regulation of Cres mRNA and protein expression by GnRH and steroid hormones, thus providing clues regarding its role in gonadotropes. Steroids 111-127 cystatin 8 (cystatin-related epididymal spermatogenic) Mus musculus 66-70 16837735-8 2006 Mouse pituitaries cultured in the absence of GnRH or steroids showed high Cres mRNA levels, while DHT or E(2) resulted in decreases of 25% and 68%, respectively. Steroids 53-61 cystatin 8 (cystatin-related epididymal spermatogenic) Mus musculus 74-78 35280986-8 2022 Within these pathways, signal-transducer-and-activator-of-transcription-1 (STAT1) protein was identified as the most significantly changed protein contributing to the pathogenesis of exacerbation and the underlying steroid resistance based on the label-free quantification; and this was further confirmed by both Parallel Reaction Monitoring (PRM) proteomics assay and western blots. Steroids 215-222 signal transducer and activator of transcription 1 Mus musculus 75-80 11550211-6 2001 Positive immunolabeling of matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) was detected in the fibromuscular layer surrounding the adenoma and adenocarcinoma induced in LP and VP after treatments with steroids for over 9-12 months. Steroids 203-211 matrix metallopeptidase 9 Rattus norvegicus 70-75 35109967-4 2022 AREG promoted cell viability, proliferation and steroid hormone output, and inhibited apoptosis. Steroids 48-55 amphiregulin Homo sapiens 0-4 35022006-0 2022 Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes. Steroids 49-56 phosphoglycolate phosphatase Mus musculus 35-39 12102262-3 2001 To obviate these problems, we studied outcome of a protocol of rapid discontinuation of prednisone (RDS) (steroids stopped on POD6). Steroids 106-114 peripherin 2 Homo sapiens 100-103 16939683-8 2006 These results suggest that, under physiological conditions, the oral bioavailability of cyclosporin A is mainly controlled by CYP3A in the upper intestine, rather than liver, but when P-gp is induced by steroid, the intestinal absorption of cyclosporin A may be inhibited. Steroids 203-210 phosphoglycolate phosphatase Mus musculus 184-188 16780839-3 2006 Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis, is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. Steroids 57-64 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 20-27 16780839-4 2006 More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. Steroids 143-150 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 46-53 11489541-5 2001 These results suggest that the gap junction with connexin-36 in the SCN is specifically regulated by ovarian steroid hormones of female rats. Steroids 109-125 gap junction protein, delta 2 Rattus norvegicus 49-60 35022006-1 2022 BACKGROUND: P-glycoprotein (P-gp)-mediated steroid resistance (SR) has been suggested to play a significant role in lupus nephritis (LN) treatment failure. Steroids 43-50 phosphoglycolate phosphatase Mus musculus 28-32 17065400-12 2006 Our results point to a complex interplay between the sex steroids and angiotensin-II in regulating adrenomedullin production by human endothelial cells, which may contribute to gender-related differences in vascular disease in humans. Steroids 57-65 adrenomedullin Homo sapiens 99-113 35069543-8 2021 The combined treatment with anti-IL-17A antibody and dexamethasone reduces steroid insensitivity in Has2 +/--OVA mice. Steroids 75-82 interleukin 17A Mus musculus 33-39 16951680-3 2006 Indian hedgehog (encoded by Ihh) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone. Steroids 115-130 Indian hedgehog Mus musculus 28-31 11508436-7 2001 All patients were treated with steroids and exhibited a good response, without relapse of angioedema and with normalization of plasma levels of C1-INH. Steroids 31-39 serpin family G member 1 Homo sapiens 144-150 11509812-4 2001 The purpose of this study was to evaluate the downregulation of these proinflammatory cytokines by dexamethasone, budesonide and recombinant IL-10 (rIL-10) in order to elucidate the mechanism of the clinical benefit of steroids in babies. Steroids 219-227 interleukin 10 Homo sapiens 141-146 2689442-5 1989 Standard hormone binding assays indicated that these receptors produced in yeast cells exhibited steroid binding affinity and specificity characteristic of the authentic chicken progesterone receptor. Steroids 97-104 progesterone receptor Gallus gallus 178-199 11509123-9 2001 Blasts from two patients with ALL during the first week of monotherapy with steroids revealed combined induction of the MDR1, multidrug resistance-associated protein 1 (MRP1), lung cancer resistance-related protein (LRP) and most PKC isozymes, predominantly PKCzeta. Steroids 76-84 protein kinase C zeta Homo sapiens 230-233 11509123-9 2001 Blasts from two patients with ALL during the first week of monotherapy with steroids revealed combined induction of the MDR1, multidrug resistance-associated protein 1 (MRP1), lung cancer resistance-related protein (LRP) and most PKC isozymes, predominantly PKCzeta. Steroids 76-84 protein kinase C zeta Homo sapiens 258-265 16842763-7 2006 These findings suggest that astrocytic GFAP in the MeA subnuclei can be affected either by physiological levels or by hormonal manipulation of the ovarian steroids, which may contribute to the plasticity of local and integrated functional activities of these brain areas in female rats. Steroids 155-163 glial fibrillary acidic protein Rattus norvegicus 39-43 16731583-7 2006 In addition, the hypothalamic KiSS-1/GPR54 system has been proven as an essential gatekeeper of GnRH neurons, involved in their activation at puberty and their regulation by gonadal steroids and (probably) metabolic factors. Steroids 182-190 KiSS-1 metastasis suppressor Homo sapiens 30-36 2532023-0 1989 Erythrocyte membrane Ca2+ ATPase: reactivities of human A, AS, and S erythrocytes with steroid hormones. Steroids 87-103 carbonic anhydrase 2 Homo sapiens 21-32 16960027-1 2006 BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects. Steroids 83-90 sulfotransferase family 2A member 1 Homo sapiens 44-49 11368871-2 2001 These steroids are potent uncompetitive inhibitors of mammalian glucose-6-phosphate dehydrogenase, the first enzyme in the pentose phosphate pathway. Steroids 6-14 glucose-6-phosphate dehydrogenase Homo sapiens 64-97 2532023-3 1989 A consistent universal stimulation of Ca2+ ATPase activity in sickle cell membranes by the different classes of steroid hormones does not appear to correlate with any major structural differences of the hormones or the presence of reactive functional groups. Steroids 112-119 carbonic anhydrase 2 Homo sapiens 38-49 2591722-5 1989 Calbindin concentration remained unchanged during the different stages of egg formation but was much higher in laying hens than in pullets treated with sex steroids. Steroids 156-164 calbindin 1 Gallus gallus 0-9 11465355-1 2001 Two experiments were conducted to evaluate the effects of the immunization of gilts against ovarian steroids on ovulation rate and litter size. Steroids 100-108 Ovulation rate Sus scrofa 112-126 16485108-0 2006 Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. Steroids 145-152 cartilage oligomeric matrix protein Homo sapiens 16-51 16485108-0 2006 Serum levels of cartilage oligomeric matrix protein (COMP): a rapid decrease in patients with active rheumatoid arthritis undergoing intravenous steroid treatment. Steroids 145-152 cartilage oligomeric matrix protein Homo sapiens 53-57 16485108-1 2006 To examine the influence of intravenous steroid-treatment (IST) on serum levels of Cartilage oligomeric matrix protein (COMP) in patients with active rheumatoid arthritis (RA). Steroids 40-47 cartilage oligomeric matrix protein Homo sapiens 83-118 11563936-6 2001 Immunocytochemical analysis revealed that during follicular growth and differentiation (48 h after PMSG) ANF was present in all steroid producing cells - interstitial, thecal and granulosa cells. Steroids 128-135 natriuretic peptide A Rattus norvegicus 105-108 2674051-11 1989 The elastin results suggest a possible mechanism contributing to obstruction of outflow in steroid glaucoma if increased amounts of elastin are also produced in vivo. Steroids 91-98 elastin Homo sapiens 4-11 11384157-3 2001 If cataract results from the direct effect of steroids on lens function, a glucocorticoid receptor is required. Steroids 46-54 nuclear receptor subfamily 3 group C member 1 Bos taurus 75-98 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). Steroids 28-36 negative elongation factor complex member C/D Homo sapiens 155-158 16485108-1 2006 To examine the influence of intravenous steroid-treatment (IST) on serum levels of Cartilage oligomeric matrix protein (COMP) in patients with active rheumatoid arthritis (RA). Steroids 40-47 cartilage oligomeric matrix protein Homo sapiens 120-124 2674051-11 1989 The elastin results suggest a possible mechanism contributing to obstruction of outflow in steroid glaucoma if increased amounts of elastin are also produced in vivo. Steroids 91-98 elastin Homo sapiens 132-139 16485108-8 2006 In contrast to the ReA group, serum-COMP levels of RA+ patients (P<0.004) and the VAS (P<0.0001) decreased significantly within 2-10 days after the first treatment with steroids. Steroids 175-183 cartilage oligomeric matrix protein Homo sapiens 36-40 11369912-8 2001 CONCLUSION: This preliminary study demonstrates that tacrolimus 0.075% ointment may be effective for patients with steroid-induced rosacea, when combined with avoidance of topical steroid use, as well as avoidance of other agents known to aggravate rosacea (caffeine, spicy foods, alcohol, hot fluids, and fluoride). Steroids 115-122 alcohol dehydrogenase iron containing 1 Homo sapiens 290-293 2759339-8 1989 Albumin fractions obtained from rat, bovine and human sera were also effective in stimulation of steroid production in the presence of LH, in contrast to chicken serum albumin which gave no stimulation. Steroids 97-104 albumin Rattus norvegicus 0-7 11375114-1 2001 More than a decade ago our view of gene regulation by glucocorticoids (GC) and other steroid hormones underwent a dramatic change with the discovery of negative crosstalk (transcriptional interference) between the GC receptor (GCR) and transcription factor AP-1 (Jun:Fos). Steroids 85-92 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 257-261 16937007-3 2006 Here we discuss two distinct classes of endogenous peptides: the steroid inducible annexin 1 and the melanocortin peptides. Steroids 65-72 annexin A1 Homo sapiens 83-92 2759339-10 1989 Our results indicate that Leydig cells are more active in steroid production when surrounded by high but physiological concentrations of albumin. Steroids 58-65 albumin Rattus norvegicus 137-144 11375114-1 2001 More than a decade ago our view of gene regulation by glucocorticoids (GC) and other steroid hormones underwent a dramatic change with the discovery of negative crosstalk (transcriptional interference) between the GC receptor (GCR) and transcription factor AP-1 (Jun:Fos). Steroids 85-92 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 267-270 2523303-9 1989 The finding that testosterone replacement for either 2 or 4 weeks to castrated rats significantly reduced POMC mRNA levels suggests that sex steroids have an inhibitory effect on the biosynthesis of POMC in the MBH. Steroids 141-149 proopiomelanocortin Rattus norvegicus 106-110 16836614-0 2006 Downregulation of human endometrial IL-18 by exogenous ovarian steroids. Steroids 63-71 interleukin 18 Homo sapiens 36-41 16836614-1 2006 PROBLEM: To evaluate the influence of ovarian steroids on IL-18, IL-15 and angiopoietin-2 mRNA expression in the endometrium in the mid luteal phase. Steroids 46-54 interleukin 18 Homo sapiens 58-63 11357060-9 2001 The present results suggested that IGFBP-4, as well as GH, IGF-I, estradiol, LH and oxytocin, is a potent regulator of porcine ovarian steroid (progesterone), nonapeptide hormone (oxytocin), growth factor (IGF-I) and growth factor-binding protein (IGFBP-3) release. Steroids 135-142 oxytocin/neurophysin I prepropeptide Homo sapiens 84-92 2523303-9 1989 The finding that testosterone replacement for either 2 or 4 weeks to castrated rats significantly reduced POMC mRNA levels suggests that sex steroids have an inhibitory effect on the biosynthesis of POMC in the MBH. Steroids 141-149 proopiomelanocortin Rattus norvegicus 199-203 2751830-1 1989 The effect of castration and gonadal steroid replacement on the concentrations of LH-beta and alpha subunit and prolactin mRNA was examined in mice. Steroids 37-44 prolactin Mus musculus 112-121 11457660-8 2001 We thus provided evidence that androstenol, the ligand for CAR and PXR, is produced by the biosynthetic pathway of sex steroids. Steroids 119-127 nuclear receptor subfamily 1 group I member 3 Homo sapiens 59-62 16463180-6 2006 Functional assays performed with a mouse tumor Leydig cell line revealed that NGF exposure increases cellular steroid production, indicating a role in differentiation processes. Steroids 110-117 nerve growth factor Mus musculus 78-81 2542952-6 1989 Our results indicate that the metabolism of parvalbumin in the caudate putamen can be influenced by variations of the blood level of this steroid hormone. Steroids 138-153 parvalbumin Rattus norvegicus 44-55 16885711-0 2006 EEG changes in a patient with steroid-responsive encephalopathy associated with antibodies to thyroperoxidase (SREAT, Hashimoto"s encephalopathy). Steroids 30-37 thyroid peroxidase Homo sapiens 94-109 11407661-5 2001 In conclusion, GFC underestimates T4 binding to VLDL and LDL, which, indeed, is of the same magnitude as binding of some steroid hormones to CBG and SHBG. Steroids 121-137 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 141-144 11306716-5 2001 The docking of synthetic compounds bearing C-11beta hydrophobic substituents within the ligand binding pocket of hAR demonstrated that precise positions of the steroid, such as C-11 and C-17, are in close contact with some residues on the receptor, C-11 with Gly 708 and C-17 with Asn705 and Thr877. Steroids 160-167 endogenous retrovirus group K member 20 Homo sapiens 43-51 2930536-1 1989 The untransformed rat glucocorticoid receptor is assumed to be a hetero-oligomeric complex, containing a non-steroid binding component, the 90K heat-shock protein (HSP 90). Steroids 109-116 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 22-45 11322787-9 2001 The results from this study demonstrate that specific, functional binding sites for the VDR can be successfully isolated from genomic DNA and should aid in the discovery of genes regulated by the steroid hormone. Steroids 196-211 vitamin D receptor Homo sapiens 88-91 16899559-2 2006 In this study, the mPRalpha and mPRbeta isoforms from zebrafish were shown to be rapidly and specifically activated by the maturation-inducing steroid (MIS) of this species, 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Steroids 143-150 progesterone receptor Mus musculus 32-39 16762492-4 2006 Kisspeptin-expressing neurons are direct targets for the negative and positive feedback actions of sex steroids, which differentially regulate the expression of KiSS-1 mRNA in various regions of the forebrain. Steroids 103-111 KiSS-1 metastasis suppressor Homo sapiens 161-167 11257226-2 2001 We demonstrate herein a novel paradigm of sex steroid action on osteoblasts, osteocytes, embryonic fibroblasts, and HeLa cells involving activation of a Src/Shc/ERK signaling pathway and attenuating apoptosis. Steroids 46-53 SHC adaptor protein 1 Homo sapiens 157-160 2909517-6 1989 We have now determined the effect of interaction with the receptor and of activation on the phosphate content of the approximately 90-kDa heat shock protein (Hsp 90), which is thought to be a non-steroid-binding subunit of nonactivated glucocorticoid receptors that dissociates on activation. Steroids 196-203 heat shock protein, 2 Mus musculus 158-164 11259506-1 2001 Steroidogenic factor-1 (SF-1), an orphan nuclear receptor, was studied with respect to the expression of steroidogenic enzymes in the hippocampus of rat and marmoset, since SF-1 is a regulator of steroid biosynthesis in the gonads. Steroids 105-112 splicing factor 1 Callithrix jacchus 24-28 2909517-10 1989 The three forms of the Hsp 90 had the same phosphate contents, as did the approximately 100-kDa steroid-binding protein before and after activation. Steroids 96-103 heat shock protein, 2 Mus musculus 23-29 11209925-4 2001 The presence of a polar group at C11 contributed to the inhibitory potency of the steroid. Steroids 82-89 RNA polymerase III subunit K Homo sapiens 33-36 16886669-2 2006 Enhancement of the synthesizing hydroxylase CYP27B1 and reduction of the catabolic CYP24 could support local accumulation of the antimitotic steroid, thus preventing formation of tumors of e.g., colon and breast. Steroids 141-148 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 83-88 2473460-8 1989 This study has led to the development of a model of steroid-induced BPH that will facilitate the evaluation of competitive androgen-receptor antagonists in the dog. Steroids 52-59 androgen receptor Canis lupus familiaris 123-140 16543268-0 2006 Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors. Steroids 34-41 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 93-98 11361002-5 2001 The presence of glucocorticoid receptor in brain mitochondria supports the concept of a direct action of glucocorticoids on mitochondrial gene transcription, parallel to the established primary actions of the hormones on nuclear gene transcription, as a mechanism of coordinate regulation of respiratory enzyme biosynthesis by steroid hormones. Steroids 327-343 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 16-39 3219167-0 1988 AAP condemns use of steroids. Steroids 20-28 serpin family F member 2 Homo sapiens 0-3 11159837-12 2001 Nurr1 induction represents a potential cross-talk mechanism between PTH and steroid hormone signaling at the transcription factor level. Steroids 76-91 nuclear receptor subfamily 4, group A, member 2 Mus musculus 0-5 11174850-3 2001 We have thus investigated the subcellular localization of two enzymes involved in the production of sex steroids, namely 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Steroids 104-112 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 121-155 16760654-6 2006 Here we will discuss data supporting the view that steroids bring about meiotic maturation through functionally redundant pathways involving synthesis of Mos or of cyclin proteins, reinforcing the robustness of the system. Steroids 51-59 MOS proto-oncogene, serine/threonine kinase Homo sapiens 154-157 2475128-0 1988 Effects of sex steroids on regulation of the levels of C1 peptide of rat prostatic steroid-binding protein mRNA evaluated by in-situ hybridization. Steroids 15-23 phosphatidylethanolamine binding protein 1 Rattus norvegicus 73-106 16684132-13 2006 Taken together, these results suggest that pituitary CART expression is dependent of the sex steroid environment and may be physiologically involved in LH secretion. Steroids 93-100 CART prepropeptide Rattus norvegicus 53-57 11174850-3 2001 We have thus investigated the subcellular localization of two enzymes involved in the production of sex steroids, namely 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD). Steroids 104-112 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 157-166 11230564-1 2001 Brassinosteroids (BRs) are plant steroids essential for normal growth and development and can be defined as steroids that carry an oxygen moiety at C-3 and additional ones at one or more of the C-2, C-6, C-22 and C-23 carbon atoms. Steroids 8-16 complement C3 Homo sapiens 148-151 11170435-1 2001 hsp90 and hsp70 are essential components of a five-protein system, including also the nonessential cochaperones Hop, hsp40, and p23, that assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding pocket to access by steroid. Steroids 242-249 heat shock protein family A (Hsp70) member 4 Homo sapiens 10-15 16720711-3 2006 The discovery that differentiating endometrium highly expresses the tumour suppressor p53, the forkhead transcription factor FOXO1, and promyelocytic leukaemia zinc finger protein (PLZF) has provided new insights into the molecular basis of life and death decisions in response to sex steroid hormones. Steroids 285-301 zinc finger and BTB domain containing 16 Homo sapiens 136-179 3183876-5 1988 We conclude that antenatal steroids increase the umbilical cord serum concentrations of retinol-binding protein, transthyretin, transferrin, retinol, and vitamin E. Steroids 27-35 transthyretin Homo sapiens 113-126 16720711-3 2006 The discovery that differentiating endometrium highly expresses the tumour suppressor p53, the forkhead transcription factor FOXO1, and promyelocytic leukaemia zinc finger protein (PLZF) has provided new insights into the molecular basis of life and death decisions in response to sex steroid hormones. Steroids 285-301 zinc finger and BTB domain containing 16 Homo sapiens 181-185 16621523-2 2006 17beta-HSD type 12, the most recently cloned member of this gene family, was classified into the 17beta-HSD family based on sequence homology, rather than steroid catalyzing activity. Steroids 155-162 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 0-18 16621523-7 2006 17beta-HSD type 12 is also detected in endocrine-related organs such as pancreas, pituitary gland, adrenal gland, testis and placenta, and in the gastrointestinal tract, which point to the possible involvement of 17beta-HSD type 12 in the regulation of lipid biosynthesis and steroid metabolism. Steroids 276-283 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 0-18 11170435-1 2001 hsp90 and hsp70 are essential components of a five-protein system, including also the nonessential cochaperones Hop, hsp40, and p23, that assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding pocket to access by steroid. Steroids 278-285 heat shock protein family A (Hsp70) member 4 Homo sapiens 10-15 11170435-10 2001 This suggests that GR-bound hsp70 is also converted from the ATP-dependent to the ADP-dependent conformation while it cooperates with hsp90 to activate steroid binding activity. Steroids 152-159 heat shock protein family A (Hsp70) member 4 Homo sapiens 28-33 11170435-11 2001 Because the priming step requires both sustained high levels of ATP and YDJ-1 for optimal activity and because both steps require potassium, we predict that receptor-bound hsp70 undergoes iterative ratcheting between its ATP- and ADP-dependent conformations in opening the hydrophobic steroid binding pocket. Steroids 285-292 heat shock protein family A (Hsp70) member 4 Homo sapiens 172-177 11053423-0 2001 Adrenodoxin reductase-adrenodoxin complex structure suggests electron transfer path in steroid biosynthesis. Steroids 87-94 ferredoxin 1 Homo sapiens 22-33 11165019-8 2001 Pan1b may be an important modulator of the endocrine, or intracrine activity of this steroid. Steroids 85-92 hydroxysteroid 17-beta dehydrogenase 11 Homo sapiens 0-5 16621523-8 2006 These results support previous reports and solidify the possibility that 17beta-HSD type 12 may play critical roles in the physiological processes, such as fatty acid synthesis, in addition to the steroid metabolism. Steroids 197-204 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 73-91 2974815-5 1988 Further evidence for an action of the adrenal steroids through the androgen receptor is indicated by competition of [3H]testosterone uptake in the tumor cells at the following IC50 values: 0.21 nM, 0.63 nM, 50 nM, 75 nM and 680 nM for DHT, testosterone, delta 4-dione, delta 5-diol and DHEA, respectively. Steroids 46-54 androgen receptor Mus musculus 67-84 11321667-1 2001 Cortisol and dehydroepiandrosterone (DHEA) and its sulphate (DHEAS) are the major steroid hormones produced by the human adrenal cortex. Steroids 82-98 sulfotransferase family 2A member 1 Homo sapiens 61-66 3133379-0 1988 Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes. Steroids 78-85 NRAS proto-oncogene, GTPase Homo sapiens 96-101 11326419-0 2001 A transgenic mouse model for investigating the response of the upstream region of whey acidic protein (WAP) gene to various steroid hormones. Steroids 124-140 whey acidic protein Mus musculus 103-106 16481018-0 2006 Efficient synthesis of C-11 functionalized steroids. Steroids 43-51 RNA polymerase III subunit K Homo sapiens 23-27 16481018-1 2006 An efficient synthesis from readily available materials of numerous steroids functionalized at C-11 position, interesting from a biological point of view, is described using our general approach. Steroids 68-76 RNA polymerase III subunit K Homo sapiens 95-99 3374131-3 1988 hEBP in cytosol binds unconjugated steroid estrogens with a medium affinity (Kd = 10(-7) M) but does not bind conjugated estrogens or unconjugated androgens, gestagens, glucocorticoids or cholesterol. Steroids 35-42 EBP cholestenol delta-isomerase Homo sapiens 0-4 16641675-1 2006 Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Steroids 15-30 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 104-122 11326419-2 2001 We studied the response of the upstream region (2.6 kb) of WAP to various steroid hormones using gonadectomized mWAP/hGH transgenic mice. Steroids 74-90 whey acidic protein Mus musculus 59-62 3372720-11 1988 These findings imply that the steroid regulation of CCK is sexually differentiated. Steroids 30-37 cholecystokinin Rattus norvegicus 52-55 11599298-1 2001 The peripheral-type benzodiazepine receptor (PBR) has been demonstrated to be critical for steroidogenesis in all steroid-producing tissues. Steroids 91-98 translocator protein Homo sapiens 4-43 11599298-1 2001 The peripheral-type benzodiazepine receptor (PBR) has been demonstrated to be critical for steroidogenesis in all steroid-producing tissues. Steroids 91-98 translocator protein Homo sapiens 45-48 16581042-4 2006 Further studies showed that the elevation of GFAP mRNA levels induced by isoproterenol and serotonin as well as progesterone was abolished by pretreatment of the glioma cells with finasteride, an inhibitor of 5alpha-reduced steroid production. Steroids 224-231 glial fibrillary acidic protein Rattus norvegicus 45-49 3372720-12 1988 The sexually dimorphic distribution of CCK-I cells in areas that are targets of steroid hormones and regulate reproductive processes is consistent with the possibility that CCK participates in central integration of sensory and steroidal input that modulates reproductive behavior. Steroids 80-96 cholecystokinin Rattus norvegicus 39-42 16581042-6 2006 These findings suggest that both adrenergic and serotonergic stimulation may indirectly activate GFAP gene expression probably through the production of 5alpha-reduced steroid metabolites in rat C6 glioma cells, proposing the possibility that 5alpha-reduced neurosteroids may play a potential role in the neuronal regulation of glial cell differentiation. Steroids 168-175 glial fibrillary acidic protein Rattus norvegicus 97-101 11599298-2 2001 Here, we review the identification and characterization of the PBR, the evidence pointing to its function as a cholesterol pore involved in transporting cholesterol from the cytoplasm of steroid-producing cells into the inner mitochondrial membrane where it is metabolized, and the known mechanisms regulating its function. Steroids 187-194 translocator protein Homo sapiens 63-66 11384880-1 2001 The 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD) isoenzymes catalyze an essential step in the formation of all classes of active steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 45-62 3372720-12 1988 The sexually dimorphic distribution of CCK-I cells in areas that are targets of steroid hormones and regulate reproductive processes is consistent with the possibility that CCK participates in central integration of sensory and steroidal input that modulates reproductive behavior. Steroids 80-96 cholecystokinin Rattus norvegicus 173-176 11384880-1 2001 The 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (3beta-HSD) isoenzymes catalyze an essential step in the formation of all classes of active steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 64-73 3343247-8 1988 The persistent estrogen induction of RBP mRNA provides the first demonstration of long-term activation of the transcription of a hormone-responsive gene in response to a transient dose of a steroid hormone. Steroids 190-205 SURP and G-patch domain containing 1 L homeolog Xenopus laevis 37-40 11785909-5 2001 The ability of PACAP to stimulate cyclic AMP formation in the hypothalamus and cerebral cortex was similar in vehicle-treated (control) and dexamethasone-treated animals, with the exception of the nucleotide response to 100 nM of the peptide in both brain regions, which was significantly larger in the group of chicks killed 48 h after the administration of the single steroid dose. Steroids 370-377 adenylate cyclase activating polypeptide 1 Gallus gallus 15-20 16537972-4 2006 Therefore, we examined the possible role of sex steroids and growth hormone in the regulation of Mrp2. Steroids 48-56 ATP binding cassette subfamily C member 2 Rattus norvegicus 97-101 16357042-6 2006 NADPH depletion by glucose deprivation minimally altered the equilibrium steroid distribution for wild-type AKR1C9 but further reduced the reductive preference of mutations R276M and R276G. Steroids 73-80 aldo-keto reductase family 1, member C14 Rattus norvegicus 108-114 11149387-7 2000 In most of these cases, prolactin was found to act synergistically or antagonistically with sex steroids. Steroids 96-104 prolactin Gallus gallus 24-33 3343254-7 1988 The purified modulator inhibits heat activation of the rat liver glucocorticoid-receptor complex and stabilizes the steroid binding ability of the unoccupied rat liver glucocorticoid receptor in a dose-dependent manner. Steroids 116-123 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 168-191 11134140-4 2000 In this study we investigated whether the female sex steroids progesterone (P) and estradiol (E(2)) regulate IL-15 messenger RNA (mRNA) and the secretion in human endometrial stromal cells (ESC) in vitro. Steroids 53-61 interleukin 15 Homo sapiens 109-114 16352595-1 2006 Although protein phosphatase magnesium-dependent 1 delta (PPM1D) was initially characterized as a p53-regulated phosphatase responsible for inactivation of p38 MAPK and consequent inactivation of p53, its overexpression and amplification in human breast cancers led us to assess its role in steroid hormone action. Steroids 291-306 protein phosphatase, Mg2+/Mn2+ dependent 1D Homo sapiens 58-63 3342067-0 1988 RU 486 stabilizes a high molecular weight form of the glucocorticoid receptor containing the 90K non-steroid binding protein in intact thymus cells. Steroids 101-108 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 54-77 2965660-3 1988 Since there is evidence that 5-androstene-3 beta, 17 beta-diol (delta 5-diol), a metabolite of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) can induce typical oestrogenic responses in target tissues, we have investigated the effect of C19 adrenal steroids and compared them to that of 17 beta-oestradiol (E2) on the above-indicated parameters. Steroids 258-266 sulfotransferase family 2A member 1 Homo sapiens 143-149 11108734-2 2000 The high expression in liver and steroidogenic tissues is compatible with a role of SR-BI in reverse cholesterol transport and steroid hormone synthesis. Steroids 127-142 scavenger receptor class B member 1 Homo sapiens 84-89 11113513-7 2000 Pharmacological properties of GABA(A) receptor at ED12 showed that positive allosteric modulation effects of the steroid 3alpha-hydroxy-5alpha-pregnan-20-one and the barbiturate pentobarbital sodium were enhanced by the treatment. Steroids 113-120 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 30-46 3334876-3 1988 In a reconstituted system, consisting of cytochrome P-450, NADPH-cytochrome-P-450 reductase and dilauroylphosphatidylcholine, cytochrome P-45017 alpha,lyase catalyzed, in addition to steroid hydroxylation, benzo[a]pyrene hydroxylation, but cytochrome P-450C21 did not hydroxylate benzo[a]pyrene. Steroids 183-190 NADPH--cytochrome P450 reductase Cavia porcellus 59-91 16457807-5 2006 Long-acting beta2-adrenoceptor agonists, on the other hand, may amplify the anti-inflammatory effects of corticosteroids by accelerating nuclear translocation of the glucocorticoid receptor complex, and enhancing transcription and expression of steroid-inducible genes in pro-inflammatory cells. Steroids 112-119 adrenoceptor beta 2 Homo sapiens 12-30 16827268-0 2006 [Immune sexual dimorphism: can sex steroids affect the Th1/Th2 cytokine profile?]. Steroids 35-43 negative elongation factor complex member C/D Homo sapiens 55-58 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Steroids 0-16 vitamin D receptor Homo sapiens 116-134 2468270-1 1988 Steroid receptors, such as the androgen receptor from the rat ventral prostate, are involved in a recycling process as part of the mechanism by which steroids affect target tissues. Steroids 150-158 androgen receptor Rattus norvegicus 31-48 11050002-3 2000 Steroid hormones exert their effect through their cognate nuclear receptors, which for vitamin D metabolites is the vitamin D receptor (VDR). Steroids 0-16 vitamin D receptor Homo sapiens 136-139 11032981-1 2000 BACKGROUND: Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEAS are neuroactive steroids. Steroids 91-99 sulfotransferase family 2A member 1 Homo sapiens 69-74 16827268-5 2006 This review focuses on the regulation of the Th1/Th2 cytokine secretion pattern of immune cells by sexual steroids. Steroids 106-114 negative elongation factor complex member C/D Homo sapiens 45-48 16480714-8 2006 This suggests that alterations of the cardiac action potentials by steroids may be mediated by interaction with the KCNQ1/KCNE1 ion channel. Steroids 67-75 potassium voltage-gated channel subfamily E regulatory subunit 1 Homo sapiens 122-127 3346653-1 1988 It is becoming increasingly clear that the neuropeptide cholecystokinin (CCK), widely distributed in the rat hypothalamus and limbic system, is subject to both organizational and activational influences of steroid hormones. Steroids 206-222 cholecystokinin Rattus norvegicus 73-76 16451215-0 2006 Expression of AMPA receptor subunits (GluR1-GluR4) in gonadotrophin-releasing hormone neurones of young and middle-aged persistently oestrous rats during the steroid-induced luteinising hormone surge. Steroids 158-165 glutamate ionotropic receptor AMPA type subunit 4 Rattus norvegicus 44-49 16310315-3 2006 These brain steroids are synthesized by cytochrome P450s (P450scc, P45017alpha and P450arom), hydroxysteroid dehydrogenases and reductases from endogenous cholesterol. Steroids 12-20 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 58-65 17374968-7 2006 Interestingly, both proapoptotic (p53 and Bax) and antiapoptotic (Bcl-2 and MDM2)genes were downregulated in osteocytes treated with high-dose steroid hormones in the hypoxic environment. Steroids 143-159 BCL2-associated X protein Mus musculus 42-45 10999937-2 2000 Nevertheless, steroids with bulky C11-substituents bind to hGR, unlike hMR. Steroids 14-22 aldo-keto reductase family 1 member C4 Homo sapiens 34-37 10999937-3 2000 In this report, a mutant hMR, in which the residue Ala-773 facing the C11 steroid position was replaced by a glycine (A773G), was assayed for its capacity to bind steroids, to interact with receptor coactivators, and to stimulate transcription. Steroids 74-81 aldo-keto reductase family 1 member C4 Homo sapiens 70-73 3346653-3 1988 Steroid activation of CCK has been indicated by findings that hypothalamic CCK levels and binding capacity vary over the estrous cycle. Steroids 0-7 cholecystokinin Rattus norvegicus 22-25 10998235-1 2000 Adrenodoxin reductase is a flavoenzyme that shuffles electrons for the biosynthesis of steroids. Steroids 87-95 ferredoxin reductase Bos taurus 0-21 3346653-3 1988 Steroid activation of CCK has been indicated by findings that hypothalamic CCK levels and binding capacity vary over the estrous cycle. Steroids 0-7 cholecystokinin Rattus norvegicus 75-78 3347046-3 1988 Ligand-free GR interacted with both resins and was eluted without loss of its steroid binding ability. Steroids 78-85 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 12-14 10967299-0 2000 Expression of estrogen receptor-alpha and c-Fos in adrenergic neurons of the female rat during the steroid-induced LH surge. Steroids 99-106 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-47 10994747-4 2000 Familial hyperaldosteronism type I(FH-I) In FH-I, inheritance of a "hybrid" 11beta-hydroxylase/aldosterone synthase gene causes adrenocorticotrophic hormone (ACTH)-regulated aldosterone and "hybrid steroid" (18hydroxy-cortisol and 18-oxo-cortisol) overproduction. Steroids 198-205 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 35-39 10994747-4 2000 Familial hyperaldosteronism type I(FH-I) In FH-I, inheritance of a "hybrid" 11beta-hydroxylase/aldosterone synthase gene causes adrenocorticotrophic hormone (ACTH)-regulated aldosterone and "hybrid steroid" (18hydroxy-cortisol and 18-oxo-cortisol) overproduction. Steroids 198-205 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 44-48 16105656-3 2005 Since these CYP11B1s are present in the zonae fasciculata and reticularis as well as in the zona glomerulosa, the zonal differentiation of steroid production may occur by the action of still-unidentified factor(s) on the enzyme-catalyzed successive oxygenations at C11- and C18-positions of steroid. Steroids 139-146 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 12-19 16105656-3 2005 Since these CYP11B1s are present in the zonae fasciculata and reticularis as well as in the zona glomerulosa, the zonal differentiation of steroid production may occur by the action of still-unidentified factor(s) on the enzyme-catalyzed successive oxygenations at C11- and C18-positions of steroid. Steroids 291-298 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 12-19 16137649-1 2005 Adrenodoxin (Adx) is a [2Fe-2S] ferredoxin involved in electron transfer reactions in the steroid hormone biosynthesis of mammals. Steroids 90-105 ferredoxin 1 Homo sapiens 13-16 16317684-7 2005 In conclusion, the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption, the substrate selectivity of the transporter, and the facilitated diffusion transport mode collectively indicate that OSTalpha-OSTbeta is a key basolateral transporter for the reabsorption of these important steroid-derived molecules. Steroids 380-387 solute carrier family 51 subunit alpha Homo sapiens 45-53 15917347-5 2005 The use of HRH1 and HRH2 selective agonists and antagonists led us to suggest that HRH2 activation would be largely responsible for stimulation of steroidogenesis, while HRH1 activation is required for inhibition of steroid synthesis. Steroids 147-154 histamine receptor H2 Mus musculus 83-87 16271526-0 2005 Flies on steroids: the interplay between ecdysone and insulin signaling. Steroids 9-17 Insulin-like receptor Drosophila melanogaster 54-61 16264191-6 2005 The conservation of NURF in mammals has broad implications for steroid signaling. Steroids 63-70 Enhancer of bithorax Drosophila melanogaster 20-24 16249504-7 2005 RESULTS: Significant associations were found between the IL-10 -1082 SNP and disease recurrence from previously stable disease and the level of steroids required for maintenance therapy. Steroids 144-152 interleukin 10 Homo sapiens 57-62 16230625-1 2005 A number of insect effector genes activated by the steroid hormone 20-hydroxyecdysone (20E) are dually controlled by the ecdysteroid receptor (EcR/USP) and products of ecdysteroid early responsive genes (E74, E75, and Broad). Steroids 51-66 ecdysone-inducible protein E75 Aedes aegypti 209-212 16046583-3 2005 OBJECTIVE AND DESIGN: To clarify the role of ovarian steroids in the differential regulation of MMP-1, MMP-3, MMP-7, MMP-8, MMP-10, TIMP-1, TIMP-2, and TIMP-3 mRNAs, we compared their variations in the cycling endometrium in vivo with their response to hormone addition or withdrawal in corresponding explants. Steroids 53-61 matrix metallopeptidase 10 Homo sapiens 124-130 16046583-7 2005 Remarkably, ovarian steroids repressed MMPs and TIMP-1 and TIMP-2 but, in secretory explants, increased TIMP-3 mRNA. Steroids 20-28 TIMP metallopeptidase inhibitor 2 Homo sapiens 59-65 16046583-7 2005 Remarkably, ovarian steroids repressed MMPs and TIMP-1 and TIMP-2 but, in secretory explants, increased TIMP-3 mRNA. Steroids 20-28 TIMP metallopeptidase inhibitor 3 Homo sapiens 104-110 16254005-0 2005 Differential regulation of interleukins IL-13 and IL-15 by ovarian steroids, TNF-alpha and TGF-beta in human endometrial epithelial and stromal cells. Steroids 67-75 interleukin 15 Homo sapiens 50-55 16254005-1 2005 Based on the endometrial spatial and temporal expression of interleukins (ILs) IL-13 and IL-15 during the normal menstrual cycle, we hypothesized that ovarian steroids and non-steroidal factors regulate their expression in a cell-specific manner. Steroids 159-167 interleukin 15 Homo sapiens 89-94 16140223-10 2005 Inhaled steroids resulted in reduced levels of IL-1 beta, IL-6, IL-8, IL-10, and IL-12 (all: P<0.01) in stable COPD (all: ex-smokers) with dose dependency for IL-8, IL-1 beta and IL-12. Steroids 8-16 interleukin 10 Homo sapiens 70-75 16172191-5 2005 The ability of BRCA1 to regulate steroid hormone action is consistent with clinical-epidemiological research suggesting that: (i) hormonal factors contribute to breast cancer risk in BRCA1 mutation carriers; and (ii) the spectrum of risk-modifying effects of hormonal factors in BRCA1 carriers is not identical to that observed in the general population. Steroids 33-48 BRCA1 DNA repair associated Homo sapiens 15-20 16172191-5 2005 The ability of BRCA1 to regulate steroid hormone action is consistent with clinical-epidemiological research suggesting that: (i) hormonal factors contribute to breast cancer risk in BRCA1 mutation carriers; and (ii) the spectrum of risk-modifying effects of hormonal factors in BRCA1 carriers is not identical to that observed in the general population. Steroids 33-48 BRCA1 DNA repair associated Homo sapiens 183-188 16172191-5 2005 The ability of BRCA1 to regulate steroid hormone action is consistent with clinical-epidemiological research suggesting that: (i) hormonal factors contribute to breast cancer risk in BRCA1 mutation carriers; and (ii) the spectrum of risk-modifying effects of hormonal factors in BRCA1 carriers is not identical to that observed in the general population. Steroids 33-48 BRCA1 DNA repair associated Homo sapiens 183-188 16240648-1 2005 The key enzymes involved in modification of the steroid nucleus of sterol-transforming mycobacteria--3beta-hydroxysteroid oxidase (3-OH-SO, EC 1.13.1.2) and 17beta-hydroxysteroid dehydrogenase (17-OH-SDH, EC 1.1.1)--were isolated and characterized. Steroids 48-55 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 200-203 15860558-3 2005 Because endothelin (ET)-1 also regulates epididymal motility, we tested its sex steroid dependence in a rabbit model. Steroids 80-87 endothelin-1 Oryctolagus cuniculus 8-25 16191269-0 2005 [Regulatory effects of inhaled steroids on expression of matrix metalloproteinase-9 and its inhibitor in asthmatic rats]. Steroids 31-39 matrix metallopeptidase 9 Rattus norvegicus 57-83 16191269-16 2005 Down-regulation of the expression of MMP-9 and TIMP-1 by steroids may be one of the mechanisms by which airway inflammation and remodeling are inhibited in asthma. Steroids 57-65 matrix metallopeptidase 9 Rattus norvegicus 37-42 16191269-16 2005 Down-regulation of the expression of MMP-9 and TIMP-1 by steroids may be one of the mechanisms by which airway inflammation and remodeling are inhibited in asthma. Steroids 57-65 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 47-53 15832374-1 2005 Cytochrome P450scc, mitochondrial adrenodoxin (Adx), and adrenodoxin reductase (AdR) are an essential components in a steroid hydroxylation system. Steroids 118-125 ferredoxin reductase Bos taurus 57-78 15832374-1 2005 Cytochrome P450scc, mitochondrial adrenodoxin (Adx), and adrenodoxin reductase (AdR) are an essential components in a steroid hydroxylation system. Steroids 118-125 ferredoxin reductase Bos taurus 80-83 15632317-1 2005 The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) isoenzymes are responsible for the oxidation and isomerization of Delta(5)-3beta-hydroxysteroid precursors into Delta(4)-ketosteroids, thus catalyzing an essential step in the formation of all classes of active steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 68-77 15632317-4 2005 Therefore, to a large extent, the 3beta-HSD gene family should have evolved to facilitate differential patterns of tissue- and cell-specific expression and regulation involving multiple signal transduction pathways, which are activated by several growth factors, steroids, and cytokines. Steroids 263-271 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 34-43 15929998-7 2005 We also found that the replacement of residues Arg(301) and Arg(304), localized near the steroid-binding cavity, significantly affects the 3alpha-HSD activity of this enzyme toward 5alpha-DHT and completely abolishes its 17beta-HSD activity on 4-dione. Steroids 89-96 aldo-keto reductase family 1 member C4 Homo sapiens 139-149 15900045-1 2005 BACKGROUND: Contrasting etiologic hypotheses about the role of endogenous sex steroids in breast cancer development among premenopausal women implicate ovarian androgen excess and progesterone deficiency, estrogen excess, estrogen and progesterone excess, and both an excess or lack of adrenal androgens (dehydroepiandrosterone [DHEA] or its sulfate [DHEAS]) as risk factors. Steroids 78-86 sulfotransferase family 2A member 1 Homo sapiens 351-356 15716590-0 2005 Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. Steroids 38-45 lysophosphatidic acid receptor 2 Mus musculus 87-91 15716590-4 2005 The LPA-induced attenuation of steroid production occurs only in the mid-cycle corpus luteum and is associated with a transient endogenous expression of mRNA for the lysophosphatidic acid A2 (LPA2) receptor (with no concomitant changes in the expression of LPA1 receptor). Steroids 31-38 lysophosphatidic acid receptor 2 Mus musculus 192-196 15759036-0 2005 Regulation of glucocorticoid receptor steroid binding and trafficking by the hsp90/hsp70-based chaperone machinery: implications for clinical intervention. Steroids 38-45 heat shock protein family A (Hsp70) member 4 Homo sapiens 83-88 15857682-0 2005 A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques. Steroids 77-85 tryptophan hydroxylase 2 Homo sapiens 41-46 15857682-8 2005 In conclusion, ovarian steroids stimulate TPH-2 mRNA expression, which could in turn cause an increase in serotonin synthesis. Steroids 23-31 tryptophan hydroxylase 2 Homo sapiens 42-47 15671029-10 2005 These findings suggest that nongenotropic modulation of kinase activity is also a general property of the VDR and that ligands that activate nongenotropic signals, but lack transcriptional activity, display different biological profiles from the steroid hormone 1alpha,25(OH)2D3. Steroids 246-261 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 106-109 15780077-2 2005 Mutations of NPHS1 and NPHS2, which encode the slit diaphragm components nephrin and podocin, cause CNS and autosomal-recessive familial steroid-resistant nephrotic syndrome, respectively. Steroids 137-144 NPHS1 adhesion molecule, nephrin Homo sapiens 13-18 15780077-2 2005 Mutations of NPHS1 and NPHS2, which encode the slit diaphragm components nephrin and podocin, cause CNS and autosomal-recessive familial steroid-resistant nephrotic syndrome, respectively. Steroids 137-144 NPHS1 adhesion molecule, nephrin Homo sapiens 73-80 15694402-4 2005 Studies in mice with knock out of the estrogen receptor, aromatase, or androgen receptor have provided important insights into the in vivo mechanisms of sex steroid action on bone. Steroids 157-164 androgen receptor Mus musculus 38-88 15795474-4 2005 The aim of our study was to investigate, if the one of neuroactive steroid--17beta-estradiol--could modulate the phosphorylation of synapsins by PKA, CaM-PK and PKC in rat brain and what type of mechanism of their action is possible. Steroids 67-74 protein kinase C, gamma Rattus norvegicus 150-164 15713538-1 2005 Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; DHEA-ST; SULT2A1) in HCC. Steroids 194-201 sulfotransferase family 2A member 1 Homo sapiens 254-261 15713538-1 2005 Differential display (DD) PCR cloning of differentially expressed genes in hepatocellular carcinoma (HCC) and adjacent unaffected tissue demonstrated preferential down-regulation of a vital sex steroid precursor (dehydroepiandrosterone sulfotransferase; DHEA-ST; SULT2A1) in HCC. Steroids 194-201 sulfotransferase family 2A member 1 Homo sapiens 263-270 15713538-4 2005 The lowered expression in tumor cells of SULT2A1 in HCC tissues involved in metabolism and/or inactivation of sex steroids is consistent with a regulatory role of the SULT2A1 gene product in the development and/or tumor cell differentiation and progression of human HCC. Steroids 114-122 sulfotransferase family 2A member 1 Homo sapiens 41-48 15576372-5 2005 This occurs in part by regulation of SGK transcription; a variety of signals including steroid hormones (aldosterone and glucocorticoids) increase SGK levels by inducing transcription of SGK. Steroids 87-103 serum/glucocorticoid regulated kinase 1 Homo sapiens 147-150 15576372-5 2005 This occurs in part by regulation of SGK transcription; a variety of signals including steroid hormones (aldosterone and glucocorticoids) increase SGK levels by inducing transcription of SGK. Steroids 87-103 serum/glucocorticoid regulated kinase 1 Homo sapiens 147-150 15647604-12 2005 Trials with the anti-ICAM-1 antisense oligonucleotide ISIS-2302 in steroid refractory Crohn"s disease have provided conflicting efficacy data. Steroids 67-74 intercellular adhesion molecule 1 Homo sapiens 21-27 15692981-2 2005 This study compared the effects of local steroid injection versus surgical decompression in new-onset CTS of at least 3 months" duration. Steroids 41-48 transthyretin Homo sapiens 102-105 15686455-8 2005 A nested mixed model regression analysis demonstrated that platelet level was the only independent variable associated with RANTES concentration (P < 0.001) among steroids, haematopoietic-colony-stimulating-factor, recombinant-human-interleukin-11, sepsis status, and neutropenia. Steroids 166-174 C-C motif chemokine ligand 5 Homo sapiens 124-130 15561099-8 2005 Both CAPON and utrophin protein levels increased in dystrophic quadriceps muscle after treatment with the steroid deflazacort plus L-arginine, known to reduce the dystrophic phenotype. Steroids 106-113 utrophin Homo sapiens 15-23 15678276-16 2005 Further increases were detected in two parameters after 1 week of therapy with steroids (tPA levels were 6.85+/-2.96 ng/mL and PAI-1 levels were 83.5+/-29.6 ng/mL). Steroids 79-87 chromosome 20 open reading frame 181 Homo sapiens 89-92 15678276-19 2005 Increases of plasma levels of PAI-1 and tPA after steroid therapy need further investigation because elevated PAI-1 levels enhance airway remodeling. Steroids 50-57 chromosome 20 open reading frame 181 Homo sapiens 40-43 15747503-6 2005 MRP4 also seems to be able to mediate the transport of conjugated steroids, prostaglandins, and glutathione. Steroids 66-74 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 16353668-7 2005 We conclude that in Y-1 cells TGF-beta inhibits the expression of SF-1 gene at a transcriptional level, and we postulate that the inhibitory effect of TGF-beta on steroid hormone synthesis in the adrenal cortex could be due to an attenuated transcription of Sf-1. Steroids 163-178 splicing factor 1 Homo sapiens 66-70 15569628-7 2005 FSH induced PCNA expression in a time dependent manner, with a maximum stimulation at 2 h. Similarly, StAR and steroid levels increased as FSH treatment time extended, with a maximum progesterone and StAR production at 48 h. ERK1/2 inactivation by UO126 inhibited the stimulatory effects of FSH on both PCNA and StAR expression and steroid synthesis in the GCs (p less than 0.01). Steroids 332-339 proliferating cell nuclear antigen Rattus norvegicus 12-16 16042365-1 2005 DHEA and its sulfate prohormone DHEAS are the most abundant circulating adrenal steroid hormones in humans. Steroids 80-96 sulfotransferase family 2A member 1 Homo sapiens 32-37 15579774-0 2004 A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women. Steroids 54-61 PR/SET domain 2 Homo sapiens 31-34 15666810-1 2004 Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown. Steroids 45-52 sulfotransferase family 2A member 1 Homo sapiens 33-38 15666810-4 2004 It was found that DHEAS at physiological concentrations (10 microM) caused inhibition of cellular growth, which was reversible following removal of the steroid. Steroids 152-159 sulfotransferase family 2A member 1 Homo sapiens 18-23 15511221-1 2004 G protein-coupled receptor 30 (GPR30) has previously been described to be important in steroid-mediated growth and to inhibit cell proliferation. Steroids 87-94 G protein-coupled estrogen receptor 1 Homo sapiens 0-29 15511221-1 2004 G protein-coupled receptor 30 (GPR30) has previously been described to be important in steroid-mediated growth and to inhibit cell proliferation. Steroids 87-94 G protein-coupled estrogen receptor 1 Homo sapiens 31-36 10880761-0 2000 Location-dependent role of the human glioma cell peripheral-type benzodiazepine receptor in proliferation and steroid biosynthesis. Steroids 110-117 translocator protein Homo sapiens 49-88 10880761-3 2000 In MGM-3 cells, PBR is located in mitochondria and the cells synthesize steroids, but do not proliferate in response to PBR ligands. Steroids 72-80 translocator protein Homo sapiens 16-19 10857570-7 2000 Linear relationships were found between the steroids: IS peak area ratios and plasma concentrations in the range of 0.1-4 mircog ml-1 for MP and MPS and 0.1-1.0 microg ml-1 for MPN and CST. Steroids 44-52 serine protease 27 Rattus norvegicus 177-180 10915175-1 2000 Liver allograft survival rates of 50% to 60% are reported in blood group A, group B, group O (ABO)-incompatible mismatched grafts even when aggressive immunosuppressive protocols, including plasmapheresis, OKT(3), cyclophosphamide, cyclosporine, prostaglandin E(1), and steroids, are used. Steroids 270-278 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 94-97 10898110-1 2000 Human prostatic steroid 5alpha-reductase, encoded by the SRD5A2 gene on chromosome band 2p23, catalyses the irreversible conversion of testosterone to dihydrotestosterone (DHT), the most active androgen in the prostate, with NADPH as its cofactor. Steroids 16-23 2,4-dienoyl-CoA reductase 1 Homo sapiens 225-230 10833461-3 2000 Among the UGT2B subfamily, UGT2B7, a UGT enzyme present in the liver and several steroid target tissues, is an important member since it conjugates a large variety of compounds including estrogens, androgens, morphine, AZT, and retinoic acid. Steroids 81-88 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 27-33 10802281-9 2000 This arrangement was also preserved in the copper(II) complex 11 with 16alpha,17beta-trans configuration of the bidentate steroid ligand and a ratio of 2:1 for ligand: copper in contrast with dimeric copper(II) complexes with a tridentate steroid ligand of 16beta, 17beta-cis configuration (ratio of 1:1 for ligand:copper). Steroids 122-129 ATPase H+ transporting accessory protein 1 Homo sapiens 70-77 10748001-0 2000 Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. Steroids 103-110 nuclear receptor subfamily 1 group I member 3 Homo sapiens 25-57 10748001-2 2000 In this report, we have systematically compared a series of xenobiotics and natural steroids for their effects on mouse and human CAR and PXR. Steroids 84-92 nuclear receptor subfamily 1 group I member 3 Homo sapiens 130-133 10748001-8 2000 Using radioligand binding and fluorescence resonance energy transfer assays, we demonstrate that several of the compounds that regulate mouse and human CAR, including natural steroids, bind directly to the receptors. Steroids 175-183 nuclear receptor subfamily 1 group I member 3 Homo sapiens 152-155 10843161-1 2000 Dehydroepiandrosterone sulfate (DHEAS) is the major secretory steroid of the human adrenal glands. Steroids 62-69 sulfotransferase family 2A member 1 Homo sapiens 32-37 10742293-20 2000 These results demonstrate the existence of a novel 17beta-oestradiol-specific PKA and Ca(2+) signalling pathway, which is both sex steroid- and gender-specific, in rat distal colonic epithelium. Steroids 131-138 KIT proto-oncogene receptor tyrosine kinase Rattus norvegicus 78-81 10760805-0 2000 Steroid- and retinoid-mediated growth arrest and apoptosis in WEHI-231 cells: role of NF-kappaB, c-Myc and CKI p27(Kip1). Steroids 0-7 cyclin-dependent kinase inhibitor 1B Mus musculus 111-114 10760805-0 2000 Steroid- and retinoid-mediated growth arrest and apoptosis in WEHI-231 cells: role of NF-kappaB, c-Myc and CKI p27(Kip1). Steroids 0-7 cyclin-dependent kinase inhibitor 1B Mus musculus 115-119 10760805-5 2000 Our results show that steroids and retinoids induce NF-kappaB inactivation, c-Myc down-regulation, p27(Kip1) up-regulation, G1 arrest, and apoptosis. Steroids 22-30 cyclin-dependent kinase inhibitor 1B Mus musculus 99-102 10760805-5 2000 Our results show that steroids and retinoids induce NF-kappaB inactivation, c-Myc down-regulation, p27(Kip1) up-regulation, G1 arrest, and apoptosis. Steroids 22-30 cyclin-dependent kinase inhibitor 1B Mus musculus 103-107 10782906-11 2000 During steroid therapy, plasma levels of the pro-inflammatory cytokine IL-8 fell as early as day 14, while levels of the anti-inflammatory cytokine IL-10 increased on day 21. Steroids 7-14 interleukin 10 Homo sapiens 148-153 10870222-4 2000 The role of the CP H in the effects of the sex steroids on the function of peptidergic systems is discussed. Steroids 47-55 carboxypeptidase E Mus musculus 16-20 10679127-9 2000 Thus, our results suggest for the first time that IL-15 may represent a physiological trigger that via cyclosporin A and steroid sensitive pathways leads to the overproduction of IL-17 in the joints of rheumatoid arthritis patients. Steroids 121-128 interleukin 15 Homo sapiens 50-55 10679127-9 2000 Thus, our results suggest for the first time that IL-15 may represent a physiological trigger that via cyclosporin A and steroid sensitive pathways leads to the overproduction of IL-17 in the joints of rheumatoid arthritis patients. Steroids 121-128 interleukin 17A Homo sapiens 179-184 10707954-6 2000 The overexpression and disrupted cellular distribution of PR in C/EBPbeta-/- mice were coincident with a striking 10-fold decrease in cell proliferation after acute steroid hormone treatment, assayed by incorporation of bromodeoxyuridine. Steroids 165-180 progesterone receptor Mus musculus 58-60 10764901-2 2000 Our previous research identified the granulin (grn) precursor gene as a sex steroid-inducible gene, which was shown to be expressed more abundantly in male than female neonates at the mediobasal hypothalamic area. Steroids 76-83 granulin precursor Rattus norvegicus 37-45 10764901-2 2000 Our previous research identified the granulin (grn) precursor gene as a sex steroid-inducible gene, which was shown to be expressed more abundantly in male than female neonates at the mediobasal hypothalamic area. Steroids 76-83 granulin precursor Rattus norvegicus 47-50 10675891-5 2000 Many of the newly identified kallikrein-like genes are regulated by steroid hormones, and a few kallikreins (NES1, protease M, PSA) are known to be downregulated in breast and possibly other cancers. Steroids 68-84 kallikrein related peptidase 4 Homo sapiens 29-39 10648663-16 2000 The clinical consequences of this possible pro-inflammatory effect of MPA on RANTES release may be abolished by a concomitant treatment with steroids. Steroids 141-149 C-C motif chemokine ligand 5 Homo sapiens 77-83 10674396-1 2000 The 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3beta-HSD) isoenzymes catalyze an essential step in the formation of all classes of active steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 64-73 11193759-1 2000 To determine the physiological function(s) of uteroglobin (UG), a steroid-inducible, homodimeric, secreted protein, we have generated transgenic mice that either are completely UG-deficient due to UG gene-knockout (UG-KO) or are partially UG-deficient due to the expression of UG antisense RNA (UG-AS). Steroids 66-73 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 46-57 10646889-10 2000 hK2 expression may therefore be a marker of steroid hormone action in breast tissue. Steroids 44-59 RBPJ pseudogene 3 Homo sapiens 0-3 10637371-1 2000 Synthetic retinoids, ligands for the RAR and RXR members of the steroid/thyroid superfamily of nuclear hormone receptors, are used for the treatment of psoriasis, acne, photoaging and cancer. Steroids 64-71 retinoid X receptor alpha Homo sapiens 45-48 10614640-5 2000 Incubation of adrenal cells with cholera toxin abolished the stimulatory effect of TTN on steroid secretion. Steroids 90-97 TTN Canis lupus familiaris 83-86 10659700-8 1999 Reversely, the lack of stable binding of pregnenolone and dehydroepiandrosterone by the mouse EST is paralleled by a lack of sulfotransferase activity of this enzyme toward these two steroids. Steroids 183-191 sulfotransferase family 1E, member 1 Mus musculus 94-97 10588816-5 1999 Using Northern analysis we investigated the uterine expression of 11betaHSD1, 11betaHSD2 and GR mRNA in relation to serum levels of sex steroid hormones and uterine progesterone receptor mRNA expression in an animal model. Steroids 136-152 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 93-95 10707545-3 1999 Sho-saiko-to-induced pneumonitis was diagnosed and steroid therapy started. Steroids 51-58 shadow of prion protein Homo sapiens 0-3 10519401-2 1999 The production of recombinant MTP in Saccharomyces cerevisiae alters sensitivity of yeast cells to a heterogeneous group of compounds (e.g., antimetabolites, antibiotics, anthracyclines, ionophores, and steroid hormones) by changing the subcellular compartmentalization of these drugs, suggesting that MTP functions similarly in higher organisms. Steroids 203-219 lysosomal-associated protein transmembrane 4A Mus musculus 30-33 10498693-3 1999 In mammals, AR plays a key role in the synthesis of all steroid hormones. Steroids 56-72 defective in the avoidance of repellents Drosophila melanogaster 12-14 10735120-10 1999 Thus, ET-1 may act as a local amplifier for oviductal PG production stimulated by LH and ovarian steroids. Steroids 97-105 endothelin 1 Bos taurus 6-10 10453058-9 1999 Steroids regulate the interactions between glia and neurons and glial gene expression, including GFAP and TGF-beta1. Steroids 0-8 glial fibrillary acidic protein Homo sapiens 97-101 10453058-12 1999 Recent data indicate that steroid treatment can decrease the expression of GFAP in the aged brain, yet GFAP is resistant to down-regulation by endogenous glucocorticoids. Steroids 26-33 glial fibrillary acidic protein Homo sapiens 75-79 10438953-11 1999 Interestingly, cytokine-mediated expression of cyclooxygenase-2 was completely abrogated by dexamethasone at 6 h. Together, these data demonstrate that cytokine-mediated NF-kappa B activation and ICAM-1 expression involve activation of a steroid-insensitive pathway. Steroids 238-245 intercellular adhesion molecule 1 Homo sapiens 196-202 10532357-1 1999 We have suggested in a previous study using 2-nm colloidal gold labeled-testosterone-bovine serum albumin (testosterone-BSA-gold) that 2-nm gold labeled-steroid hormone-BSA conjugates would be a useful tool for analyzing the mechanism of steroid hormone action (39). Steroids 153-168 albumin Rattus norvegicus 92-105 10532357-1 1999 We have suggested in a previous study using 2-nm colloidal gold labeled-testosterone-bovine serum albumin (testosterone-BSA-gold) that 2-nm gold labeled-steroid hormone-BSA conjugates would be a useful tool for analyzing the mechanism of steroid hormone action (39). Steroids 238-253 albumin Rattus norvegicus 92-105 10404824-1 1999 Lecithin:cholesterol acyltransferase (LCAT), the enzyme that esterifies cholesterol in blood, also esterifies other steroids at the 3beta-hydroxyl. Steroids 116-124 lecithin-cholesterol acyltransferase Homo sapiens 0-36 10404824-1 1999 Lecithin:cholesterol acyltransferase (LCAT), the enzyme that esterifies cholesterol in blood, also esterifies other steroids at the 3beta-hydroxyl. Steroids 116-124 lecithin-cholesterol acyltransferase Homo sapiens 38-42 10404824-5 1999 We investigated the substrate specificity of LCAT, comparing the esterification of four different steroids (estradiol, estriol, testosterone, and 5-androstene-3beta, 17beta-diol) by human LCAT in blood and by acyl-coenzyme A:acyltransferase in tissue (placenta and fat). Steroids 98-106 lecithin-cholesterol acyltransferase Homo sapiens 45-49 10404824-5 1999 We investigated the substrate specificity of LCAT, comparing the esterification of four different steroids (estradiol, estriol, testosterone, and 5-androstene-3beta, 17beta-diol) by human LCAT in blood and by acyl-coenzyme A:acyltransferase in tissue (placenta and fat). Steroids 98-106 lecithin-cholesterol acyltransferase Homo sapiens 188-192 10226060-0 1999 Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment. Steroids 118-125 matrix metallopeptidase 9 Homo sapiens 27-57 10198348-5 1999 The results establish the polyspecific nature of Oatp1 in a mammalian expression system and definitely identify conjugated dihydroxy bile salts and steroid conjugates as high-affinity endogenous substrates of Oatp1. Steroids 148-155 ornithine aminotransferase pseudogene 1 Homo sapiens 209-214 10101033-8 1999 Several organic anions, bile acids, cardiac glycosides, and steroids had potent inhibitory effects on the OAT-K2-mediated taurocholate transport in the transfectant. Steroids 60-68 solute carrier organic anion transporter family member 1A3 Rattus norvegicus 106-112 10399884-6 1999 These results indicated that the region containing the C-6 position of the parent seco-steroid [1,25(OH)2D3] may be an important recognition marker towards vitamin D receptor binding. Steroids 87-94 vitamin D receptor Homo sapiens 156-174 10210767-3 1999 Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn"s disease refractory to steroids. Steroids 226-234 interleukin 10 Homo sapiens 144-149 12160215-7 1999 Expression of tenascin, showing changes depending on the menstrual phase, appears to be influenced by ovarian steroid hormones, and it might play a role in regulating human endometrial development by interaction with mitotic cells. Steroids 110-126 tenascin C Homo sapiens 14-22 10416831-2 1999 We also examined the effect of steroid hormones on expression of the genes encoding the steroidogenic enzymes, cytochrome P450-cholesterol side chain cleavage (P450scc) and 3beta-hydroxy-5-ene steroid dehydrogenase (3beta-HSD). Steroids 31-38 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 173-214 10464876-3 1999 The aim of the study was to assess the number of eosinophils and the levels of eosinophil cationic protein (ECP) in sputum of 17 corticosteroid-dependent asthmatics by comparison with nine mild untreated asthmatics, 10 moderate asthmatics receiving inhaled steroids (ICS) and 11 healthy subjects. Steroids 257-265 ribonuclease A family member 3 Homo sapiens 108-111 10076896-5 1999 Furthermore, our results demonstrate that melatonin and 5alpha-pregnan-3alpha-ol-20-one (a positive steroid modulator of the GABA(A) receptor) act through different sites. Steroids 100-107 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 125-141 15519892-3 2004 Mice lacking GPR54 fail to undergo puberty and have immature reproductive organs and low levels of sex steroids and gonadotrophic hormones, but have normal levels of gonadotrophin-releasing hormone in the hypothalamus. Steroids 103-111 KISS1 receptor Mus musculus 13-18 15485793-0 2004 [Brain-derived neurotrophin factor inhibits steroid biosynthesis by human granulosa-lutein cells]. Steroids 44-51 brain derived neurotrophic factor Homo sapiens 1-34 15525575-3 2004 To address the potential regulation of H19 gene expression by an androgen steroid hormone (DHT: dihydrotestosterone) or by a peptidic hormone (PRL: prolactin), we performed experiments in rats systemically treated with chemical mediators. Steroids 74-89 H19, imprinted maternally expressed transcript (non-protein coding) Rattus norvegicus 39-42 3386251-0 1988 Relationship between glucocorticoid receptor steroid-binding capacity and association of the Mr 90,000 heat shock protein with the unliganded receptor. Steroids 45-52 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 21-44 9927378-0 1999 Serum matrix metalloproteinase-9:Tissue inhibitor of metalloproteinase-1 ratio correlates with steroid responsiveness in moderate to severe asthma. Steroids 95-102 matrix metallopeptidase 9 Homo sapiens 6-72 3386251-1 1988 Treatment of rat liver cytosol with hydrogen peroxide (H2O2) or sodium molybdate (MoO4(2-)) inhibits thermal inactivation of glucocorticoid receptor steroid-binding capacity at 25 degrees C. Dithiothreitol (DTT) prevents the stabilization of receptors by H2O2. Steroids 149-156 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 125-148 15465758-5 2004 Withdrawal of gonadal steroids by ovariectomy resulted in an increase in the activity state of BCKDC and a decrease in the activity of the branched-chain alpha-keto acid dehydrogenase kinase (BDK). Steroids 22-30 branched chain ketoacid dehydrogenase kinase Rattus norvegicus 139-190 3386251-2 1988 Heating (25 degrees C) of immune pellets formed by immunoadsorption of L-cell murine glucocorticoid receptor complexes to protein-A-Sepharose with an anti-receptor monoclonal antibody (BuGR2) results in dissociation of the M 90,000 heat shock protein (hsp90) from the steroid binding protein. Steroids 268-275 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 85-108 3386251-5 1988 These data suggest a role for hsp90 in maintaining an active steroid-binding conformation of the glucocorticoid receptor. Steroids 61-68 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 97-120 15518791-0 2004 Excellent outcome of ABO-incompatible living kidney transplantation under pretransplantation immunosuppression with tacrolimus, mycophenolate mofetil, and steroid. Steroids 155-162 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 21-24 10073574-10 1999 These results demonstrate that the Ov NRE contains not only sites responsible for the repression of the gene but also a positive element that is required for responsiveness to steroid hormones. Steroids 176-192 ovalbumin (SERPINB14) Gallus gallus 35-37 3386275-4 1988 Thus PR expression can be used as a marker for action and sensitivity of cells to these sex steroids. Steroids 92-100 progesterone receptor Gallus gallus 5-7 2447485-2 1988 The steroid and peptide hormones stimulate expression of the AGP gene synergistically as well as independently. Steroids 4-11 orosomucoid 1 Rattus norvegicus 61-64 10442572-4 1999 It has also been reported that sex steroids influence not only GH secretion but also the local synthesis of IGF-I in target tissues and the expression of the GH receptor in various other tissues. Steroids 35-43 growth hormone receptor Homo sapiens 158-169 15163435-1 2004 Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-S are neurosteroids, produced in the brain, and neuroactive steroids, produced in the adrenals and affecting the brain. Steroids 73-81 sulfotransferase family 2A member 1 Homo sapiens 57-63 15131259-1 2004 The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3betaHSD) is required for the biosynthesis of all active steroid hormones. Steroids 114-130 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-55 3074339-8 1988 Similarly, although oxytocin"s function in steroid-producing tissues is not fully established, recent in vitro data has shown that oxytocin can inhibit androgen and estrogen production, and thus may act in a local regulatory fashion. Steroids 43-50 oxytocin/neurophysin I prepropeptide Homo sapiens 20-28 15131259-1 2004 The enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3betaHSD) is required for the biosynthesis of all active steroid hormones. Steroids 114-130 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 57-65 15199138-0 2004 Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Steroids 19-34 RAD54 like 2 Homo sapiens 93-98 9892013-11 1999 Such an induction of the 3beta-HSD activity may modulate androgenic and estrogenic biological responses as demonstrated using ZR-75-1 cells transfected with androgen- or estrogen-sensitive reporter constructs and treated with the adrenal steroid 5-androstene-3beta,17beta-diol. Steroids 238-245 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 25-34 9892013-16 1999 Our data demonstrate for the first time that IL-4 and IL-13 induce 3beta-HSD type 1 gene expression, thus suggesting their involvement in the fine control of sex steroid biosynthesis from adrenal steroid precursors in normal and tumoral human mammary cells. Steroids 162-169 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-76 9892013-16 1999 Our data demonstrate for the first time that IL-4 and IL-13 induce 3beta-HSD type 1 gene expression, thus suggesting their involvement in the fine control of sex steroid biosynthesis from adrenal steroid precursors in normal and tumoral human mammary cells. Steroids 196-203 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-76 3319051-10 1987 The steroid-induced changes in cell nuclear immunoreactive GR staining intensity suggest possible cytoplasmic-cell nuclear translocation of GR and/or exposure of immunogenic GR domains. Steroids 4-11 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 59-61 9856533-1 1998 Blastokinin or uteroglobin (UG) is an evolutionarilly conserved, steroid-inducible, homodimeric, multifunctional, secreted protein with potent Immunomodulatory/antiinflammatory properties. Steroids 65-72 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 0-11 15082231-2 2004 The percentage increases in the brain and plasma concentrations of these neuroactive steroids apparent 30 min after intraperitoneal injection of the peripheral benzodiazepine receptor (PBR) ligand CB 34 (25 mg/kg) have now been shown to be markedly greater in isolated rats than in group-housed controls. Steroids 85-93 translocator protein Rattus norvegicus 149-183 15082231-2 2004 The percentage increases in the brain and plasma concentrations of these neuroactive steroids apparent 30 min after intraperitoneal injection of the peripheral benzodiazepine receptor (PBR) ligand CB 34 (25 mg/kg) have now been shown to be markedly greater in isolated rats than in group-housed controls. Steroids 85-93 translocator protein Rattus norvegicus 185-188 15004017-4 2004 We determined that the nuclear receptor CAR is required to coordinately up-regulate hepatic expression of Mrp4 and an enzyme known to sulfate hydroxy-bile acids and steroids, Sult2a1. Steroids 165-173 ATP binding cassette subfamily C member 4 Homo sapiens 106-110 9856533-1 1998 Blastokinin or uteroglobin (UG) is an evolutionarilly conserved, steroid-inducible, homodimeric, multifunctional, secreted protein with potent Immunomodulatory/antiinflammatory properties. Steroids 65-72 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 15-26 9856533-1 1998 Blastokinin or uteroglobin (UG) is an evolutionarilly conserved, steroid-inducible, homodimeric, multifunctional, secreted protein with potent Immunomodulatory/antiinflammatory properties. Steroids 65-72 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 28-30 15004017-4 2004 We determined that the nuclear receptor CAR is required to coordinately up-regulate hepatic expression of Mrp4 and an enzyme known to sulfate hydroxy-bile acids and steroids, Sult2a1. Steroids 165-173 sulfotransferase family 2A member 1 Homo sapiens 175-182 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-109 ATP binding cassette subfamily C member 4 Homo sapiens 63-67 3319051-10 1987 The steroid-induced changes in cell nuclear immunoreactive GR staining intensity suggest possible cytoplasmic-cell nuclear translocation of GR and/or exposure of immunogenic GR domains. Steroids 4-11 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 140-142 2820972-4 1987 Detailed study of the adrenocortical steroid biosynthetic pathway by high performance liquid chromatography analysis and supply of representative steroid substrates revealed a drastic loss (average 50%) of the steroid 17 alpha-hydroxylase activity following TGF treatment. Steroids 37-44 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 210-238 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-109 ATP binding cassette subfamily C member 4 Homo sapiens 137-141 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-109 sulfotransferase family 2A member 1 Homo sapiens 146-153 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-108 ATP binding cassette subfamily C member 4 Homo sapiens 63-67 9881654-2 1998 This enzyme is distinct from 3alpha/beta,20beta-hydroxysteroid dehydrogenase or its homologue, carbonyl reductase, as judged by its immunological and molecular properties and its much narrower specificity for steroids. Steroids 209-217 carbonyl reductase [NADPH] 1 Sus scrofa 29-76 9832435-3 1998 The ovalbumin gene contains one such unit, known as the steroid-dependent regulatory element. Steroids 56-63 ovalbumin (SERPINB14) Gallus gallus 4-13 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-108 ATP binding cassette subfamily C member 4 Homo sapiens 137-141 2959818-5 1987 From incubations of testes homogenates with various labelled steroid precursors it could be inferred that the activity of the 17 alpha-hydroxylase, the 3 beta-hydroxysteroid dehydrogenase-isomerase and the 17 beta-hydroxysteroid dehydrogenase, expressed per unit of incubated protein, was significantly increased in the testes of the androgenized rats. Steroids 61-68 aldo-keto reductase family 1, member C12 Rattus norvegicus 206-242 15004017-7 2004 Based on the hydrophilic nature of sulfated bile acids and the Mrp4 capability to transport sulfated steroids, our findings suggest that Mrp4 and Sult2a1 participate in an integrated pathway mediating elimination of sulfated steroid and bile acid metabolites from the liver. Steroids 101-108 sulfotransferase family 2A member 1 Homo sapiens 146-153 15128937-7 2004 Using a steroid-inducible activation of RGA, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA activity in young flowers whereas the expression of LEAFY (LFY) and APETALA1 (AP1) is not substantially affected. Steroids 8-15 GRAS family transcription factor family protein Arabidopsis thaliana 40-43 15128937-7 2004 Using a steroid-inducible activation of RGA, we further demonstrated that these floral homeotic genes are transcriptionally repressed by RGA activity in young flowers whereas the expression of LEAFY (LFY) and APETALA1 (AP1) is not substantially affected. Steroids 8-15 GRAS family transcription factor family protein Arabidopsis thaliana 137-140 9832454-1 1998 Specific zonal localization and developmental regulation of CYP21A2 (P450c21) and CYP11B1/CYP11B2 (P450c11/aldosterone synthase) lead to integrated concept of zonal and temporal steroid biosynthesis. Steroids 178-185 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 82-89 9832454-1 1998 Specific zonal localization and developmental regulation of CYP21A2 (P450c21) and CYP11B1/CYP11B2 (P450c11/aldosterone synthase) lead to integrated concept of zonal and temporal steroid biosynthesis. Steroids 178-185 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 99-106 3607744-10 1987 Physiologically, the enhanced intratumoral availability of beta-glucuronidase and other lysosomal enzymes might facilitate the hydrolysis of conjugates of a variety of xenobiotics and, possibly, also of steroid hormones. Steroids 203-219 glucuronidase, beta Rattus norvegicus 59-77 9864282-0 1998 The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel. Steroids 69-76 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 12-17 14761937-2 2004 However, it is unclear if this is a result of release of affected bone marrow neutrophils or if the steroid has direct effects on L-selectin expression in existing blood neutrophils. Steroids 100-107 L-selectin Bos taurus 130-140 14761937-3 2004 We recently demonstrated that circulating neutrophils from cattle with high blood concentrations of endogenous glucocorticoid had reduced L-selectin mRNA, suggesting that the steroid interrupted L-selectin gene expression. Steroids 175-182 L-selectin Bos taurus 138-148 3665877-0 1987 The chicken ovalbumin promoter is under negative control which is relieved by steroid hormones. Steroids 78-94 ovalbumin (SERPINB14) Gallus gallus 12-21 14761937-3 2004 We recently demonstrated that circulating neutrophils from cattle with high blood concentrations of endogenous glucocorticoid had reduced L-selectin mRNA, suggesting that the steroid interrupted L-selectin gene expression. Steroids 175-182 L-selectin Bos taurus 195-205 15225803-8 2004 Only the combined treatment with 1alpha,25-(OH)(2)-vitamin D(3) and 17beta-estradiol resulted in a significant reduction of glial heat shock protein-32 immunoreactivity within the lesion-remote cortical areas supplied by the affected middle cerebral artery (MCA), indicating that both steroids act synergistically in a protective manner. Steroids 285-293 heme oxygenase 1 Rattus norvegicus 130-151 9872360-2 1998 Interactions between steroid receptors and transcription proteins, e.g. c-JUN/AP-1, can modulate steroid action at the transcriptional level. Steroids 21-28 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 72-77 9872360-2 1998 Interactions between steroid receptors and transcription proteins, e.g. c-JUN/AP-1, can modulate steroid action at the transcriptional level. Steroids 21-28 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 78-82 15135080-8 2004 The induction of the steroid biotransformation enzymes is partly mediated through the activation of a group of nuclear receptors including the glucocorticoid receptor, the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and the peroxisome proliferator activated receptors (PPAR). Steroids 21-28 nuclear receptor subfamily 1 group I member 3 Homo sapiens 172-204 15135080-8 2004 The induction of the steroid biotransformation enzymes is partly mediated through the activation of a group of nuclear receptors including the glucocorticoid receptor, the constitutive androstane receptor (CAR), the pregnane X receptor (PXR), and the peroxisome proliferator activated receptors (PPAR). Steroids 21-28 nuclear receptor subfamily 1 group I member 3 Homo sapiens 206-209 3665877-1 1987 Steroid hormone regulation of activity of the chicken ovalbumin promoter was studied by microinjection of chimeric genes into the nuclei of primary cultured oviduct tubular gland cells. Steroids 0-15 ovalbumin (SERPINB14) Gallus gallus 54-63 3665877-4 1987 The activity of the ovalbumin promoter is cell-specifically repressed in these oviduct cells and the repression is relieved upon addition of steroid hormones. Steroids 141-157 ovalbumin (SERPINB14) Gallus gallus 20-29 9883011-8 1998 Although the precise mechanism of action is not completely understood, it appears that a single infusion of this monoclonal antibody (cA2) can induce remission in a high percentage of steroid dependent, chronic active patients with Crohn"s disease. Steroids 184-191 carbonic anhydrase 2 Homo sapiens 134-137 3665877-5 1987 The -132 to -425 region of the ovalbumin promoter which is responsible for this negative regulation behaves as an independent functional unit containing the regulatory elements necessary for both repression (in the presence of steroid hormone antagonists) and induced derepression (in the presence of steroid hormones) of linked heterologous promoters. Steroids 227-242 ovalbumin (SERPINB14) Gallus gallus 31-40 3665877-5 1987 The -132 to -425 region of the ovalbumin promoter which is responsible for this negative regulation behaves as an independent functional unit containing the regulatory elements necessary for both repression (in the presence of steroid hormone antagonists) and induced derepression (in the presence of steroid hormones) of linked heterologous promoters. Steroids 301-317 ovalbumin (SERPINB14) Gallus gallus 31-40 3110162-11 1987 These data show that at least two forms of UDP-glucuronosyltransferase found predominantly in the liver have evolved to glucuronidate the same endogenous steroid substrates and that the phenobarbital-inducible form also has some activity towards foreign compounds. Steroids 154-161 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 43-70 9849842-1 1998 BACKGROUND: Circulating vasopressin and oxytocin are influenced by ovarian steroid blood levels, but the effect of estrogen and progestogen treatment on induced release of the posterior pituitary hormones is not clear. Steroids 75-82 oxytocin/neurophysin I prepropeptide Homo sapiens 40-48 15177053-4 2004 Both in vitro and in vivo experimental studies strongly indicate that DHEA and related steroids inhibit inflammation and associated epithelial hyperplasia, carcinogenesis, and atherosclerosis, at least in part, through the inhibition of G6PDH and oxygen-free radical formation. Steroids 87-95 glucose-6-phosphate dehydrogenase Homo sapiens 237-242 3609019-1 1987 The molybdate-stabilized rat liver glucocorticoid receptor complex was purified 9000-fold with a 46% yield by steroid-affinity chromatography and DEAE-Sephacel ion-exchange chromatography. Steroids 110-117 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 35-58 2954550-0 1987 Effects of steroid and thyroid hormones on synthesis of atrial natriuretic peptide by cultured atrial myocytes of rat. Steroids 11-18 natriuretic peptide A Rattus norvegicus 56-82 15028527-12 2004 The change in the PRB:PRA ratio after hormonal treatment confirms that progesterone and estrogen exposure will be a determinant in the regulation of vitellogenesis, and, in turn, that the regulation of vitellogenesis will be determined by the ratio of PR isoforms and the physiological levels of steroid hormones. Steroids 296-312 progesterone receptor Chrysemys picta 18-20 14672942-0 2004 Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action. Steroids 174-189 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 112-146 9951626-3 1998 It has also been found that the gene expression of Po and MBP is dramatically decreased in the myelin of the sciatic nerve of aged male rats and that the aged-linked decrease of the gene expression of Po is partially reversible with steroid treatment. Steroids 233-240 myelin basic protein Rattus norvegicus 58-61 9951633-7 1998 Thus, DHEA-S may serve as a physiological modulator of liver fatty acid metabolism and peroxisomal enzyme expression, and thereby may contribute to the anticarcinogenic and chemoprotective properties of this intriguing class of endogenous steroids. Steroids 239-247 sulfotransferase family 2A member 1 Homo sapiens 6-12 9951633-10 1998 The cortisol/DHEA-S ratio during the life span follows a U-shape curve, which may be telling us to explore these two critical adrenal steroids in tandem. Steroids 134-142 sulfotransferase family 2A member 1 Homo sapiens 13-19 3586778-0 1987 [Similar mechanisms of action of steroid hormones, vitamin D, thyroid hormone and an oncogen, v-erbA]. Steroids 33-49 thyroid hormone receptor alpha Homo sapiens 96-100 9778236-0 1998 Role of sex steroids in the Th1/Th2 cytokine balance: comment on the article by Miossec and van den Berg. Steroids 12-20 negative elongation factor complex member C/D Homo sapiens 28-31 14967152-1 2004 Dehydroepiandrosterone sulfate (DHEAS) is a 19-carbon steroid, situated along the steroid metabolic pathway. Steroids 54-61 sulfotransferase family 2A member 1 Homo sapiens 32-37 2954320-1 1987 Energetically favourable conformations for simultaneous intramolecular rotations of both the 17 alpha ethyl side chain and the 17 beta hydroxyl group of a model steroid are calculated by MM2 molecular mechanics. Steroids 161-168 PNMA family member 2 Homo sapiens 187-190 15026188-1 2004 CYP11B1 and the closely related CYP11B2 are involved in the production of adrenal steroid hormones. Steroids 82-98 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 9799628-0 1998 Prenatal gonadal steroids affect adult spatial behavior, CA1 and CA3 pyramidal cell morphology in rats. Steroids 17-25 carbonic anhydrase 3 Rattus norvegicus 65-68 9768686-3 1998 In the present study, we examined the hypothesis that alterations in intra-adrenal expression of 3beta-hydroxysteroid dehydrogenase (3betaHSD) or 21-hydroxylase (CYP21) within the inner reticularis zone leads to the increased production of 19-carbon (C19) steroids. Steroids 256-264 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 97-131 3812760-4 1987 The activity of 3-hydroxy-3-methylglutaryl-CoA reductase, the rate-limiting enzyme of steroid biosynthesis, was 80% lower (P less than 0.01). Steroids 86-93 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 16-56 9768686-3 1998 In the present study, we examined the hypothesis that alterations in intra-adrenal expression of 3beta-hydroxysteroid dehydrogenase (3betaHSD) or 21-hydroxylase (CYP21) within the inner reticularis zone leads to the increased production of 19-carbon (C19) steroids. Steroids 256-264 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 133-141 9768686-5 1998 The enzyme 3betaHSD competes for substrate with CYP17 and effectively removes steroid precursor from the pathway leading to DHEA. Steroids 78-85 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-19 9922986-0 1998 Expression of CD44 variant isoforms in leukocytes of the joint fluid of rheumatoid arthritis patients and the effect of steroids. Steroids 120-128 CD44 molecule (Indian blood group) Homo sapiens 14-18 9922986-3 1998 We also examined the effects of steroids (prednisolone and/or dexamethasone palmitate) and some disease-modifying antirheumatic drugs (DMARDs) on the expressions of CD44 variants. Steroids 32-40 CD44 molecule (Indian blood group) Homo sapiens 165-169 14975704-3 2004 We here examined the pharmacological efficacy of igmesine and (+)-SKF-10,047 and the sigma(1) receptor-related neuroactive steroid dehydroepiandrosterone sulfate, in rats infused intracerebroventricularly during 14 days with the beta-amyloid-(1-40) protein and then submitted to the conditioned fear stress test. Steroids 123-130 sigma non-opioid intracellular receptor 1 Rattus norvegicus 85-102 14755437-2 2004 The polypeptide binds to the peripheral, or mitochondrial, benzodiazepine receptor and facilitates transport of cholesterol to the inner membrane to stimulate steroid synthesis. Steroids 159-166 translocator protein Homo sapiens 44-82 14977918-1 2004 Perception of the plant steroid hormone brassinolide (BL) by the membrane-associated receptor kinase BRI1 triggers the dephosphorylation and accumulation in the nucleus of the transcriptional modulators BES1 and BZR1. Steroids 24-39 Brassinosteroid signaling positive regulator (BZR1) family protein Arabidopsis thaliana 212-216 9824214-1 1998 Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are endogenous steroids that have recently been widely publicized as potential treatments for many disorders. Steroids 88-96 sulfotransferase family 2A member 1 Homo sapiens 66-71 3034566-2 1987 Antiinflammatory steroids and estradiols were highly inhibitory to 3 alpha-hydroxysteroid dehydrogenase and one isozyme of testosterone 17 beta-dehydrogenase, respectively, but nonsteroidal antiinflammatory agents and nonsteroidal estrogens such as hexestrol, dienstrol, diethylstilbestrol and zearalenone showed potent inhibitions on all the enzymes. Steroids 17-25 aldo-keto reductase family 1, member C14 Rattus norvegicus 67-103 9729461-1 1998 Pig 3alpha/beta,20beta-hydroxysteroid dehydrogenase is an NADPH-dependent enzyme that catalyses the reduction of ketones on steroids and aldehydes and ketones on various xenobiotics, like its homologue carbonyl reductase. Steroids 124-132 carbonyl reductase [NADPH] 1 Sus scrofa 4-51 3778686-2 1986 Compared with controls (12.5 +/- 3.0 mg/dl), HRG levels were significantly decreased in patients with AIDS (5.7 +/- 1.8 mg/dl, P less than 0.005): in patients with ESRD after renal transplantation with steroid therapy (4.4 +/- 1.1 mg/dl, P less than 0.005); and in asthmatic and COPD patients receiving steroids in acute (7.6 +/- 2.9 mg/dl, P less than 0.005) or chronic (7.4 +/- 3.0 mg/dl, P less than 0.025) high-dose regimens. Steroids 303-311 histidine rich glycoprotein Homo sapiens 45-48 9744489-8 1998 These data describing a parallel change in the number of oestrogen receptors and LHbeta containing cells in the pituitary gland throughout gestation suggest that the development of pituitary sex-steroid feedback is not solely dependent on changes in the numbers of oestrogen receptor containing cells alone. Steroids 195-202 luteinizing hormone subunit beta Homo sapiens 81-87 3778686-4 1986 These results show that serum HRG levels are selectively decreased in AIDS and in patients treated with immunosuppressive steroids. Steroids 122-130 histidine rich glycoprotein Homo sapiens 30-33 9786151-4 1998 Staging of CTS was done on the basis of clinical and electrophysiological testing, including evaluation of the number of previous steroid infiltrations in conservative treatment. Steroids 130-137 transthyretin Homo sapiens 11-14 3023052-1 1986 A plasmid has been constructed which contains the normal human N-ras proto-oncogene under the transcriptional control of the steroid-sensitive promoter of the mouse mammary tumor virus long terminal repeat. Steroids 125-132 NRAS proto-oncogene, GTPase Homo sapiens 63-68 9685410-4 1998 Data presented here demonstrates that TSC2 protein can bind and selectively modulate transcription mediated by members of the steroid receptor superfamily of genes. Steroids 126-133 TSC complex subunit 2 Homo sapiens 38-42 9771468-1 1998 The 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) family of proteins regulates the levels of the active 17 beta-hydroxy forms of sex steroids. Steroids 138-146 aldo-keto reductase family 1, member C12 Rattus norvegicus 4-40 14563706-2 2004 In the present study, we showed, by using various recombinant cytochrome P450 (CYP)2D enzymes and anti-CYP2D4- or P450c21-specific antibodies, that rat brain microsomal steroid 21-hydroxylation is catalyzed not by P450c21, but by CYP2D isoforms. Steroids 169-176 cytochrome P450, family 2, subfamily d, polypeptide 4 Rattus norvegicus 103-109 15004431-2 2004 We previously found that NT immunoreactivity is present in the secretory granules of gonadotropes and thyrotropes in both male and female rats, where its levels of expression are under the control of sex steroids. Steroids 204-212 neurotensin Rattus norvegicus 25-27 15004431-9 2004 These findings indicate that NT expression in the rat anterior pituitary is cell specific, and develops from birth to adulthood under the control of sex steroid hormones. Steroids 153-169 neurotensin Rattus norvegicus 29-31 9771468-8 1998 Our results demonstrate that 17 beta-HSD IV is induced by PPC through a PPAR alpha-dependent mechanism and support the hypothesis that exposure to PPC leads to alterations in sex steroid metabolism. Steroids 179-186 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 29-40 3758383-9 1986 The steroid-impregnated polysiloxane vaginal ring and cylinder system provided continuous and sustained hormone release, morphologically and endocrinologically normal endometrium, serum levels of E2 and P within the normal range for the entire menstrual cycle, and a convenient and physiologic therapeutic alternative to oral, vaginal, or intramuscular steroid replacement. Steroids 4-11 cystatin 12, pseudogene Homo sapiens 196-204 9657682-1 1998 Delta 4-3-Ketosteroid-5 beta-reductase (5 beta-reductase) precedes 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) in steroid hormone metabolism. Steroids 121-136 aldo-keto reductase family 1, member D1 Rattus norvegicus 0-38 9657682-1 1998 Delta 4-3-Ketosteroid-5 beta-reductase (5 beta-reductase) precedes 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) in steroid hormone metabolism. Steroids 121-136 aldo-keto reductase family 1, member C14 Rattus norvegicus 67-103 9657682-1 1998 Delta 4-3-Ketosteroid-5 beta-reductase (5 beta-reductase) precedes 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) in steroid hormone metabolism. Steroids 121-136 aldo-keto reductase family 1, member C14 Rattus norvegicus 105-116 15550762-0 2004 Steroid therapy altered serum levels of CCL2 and CCL5 chemokines in multiple sclerosis patients during relapse. Steroids 0-7 C-C motif chemokine ligand 5 Homo sapiens 49-53 15550762-2 2004 The aim of this study was to determine the impact of steroid therapy on the levels of CCL2 and CCL5 chemokines. Steroids 53-60 C-C motif chemokine ligand 5 Homo sapiens 95-99 3808848-2 1986 Eight children with steroid-response nephrotic syndrome were investigated to study the relation-ship between steroid responsive syndrome, allergy and HLA-antigens. Steroids 20-27 inositol polyphosphate-5-phosphatase D Homo sapiens 96-100 19058560-2 2004 Therefore, the aim of the present study was to determine whether in the domestic hen prolactin influences in vitro steroid secretion by white and yellow chicken ovarian follicles. Steroids 115-122 prolactin Gallus gallus 85-94 19058560-6 2004 It was found that prolactin affects steroid secretion by chicken ovarian follicles. Steroids 36-43 prolactin Gallus gallus 18-27 19058560-7 2004 In white follicles prolactin inhibits estradiol secretion, whereas in yellow preovulatory follicles it stimulates or inhibits steroid secretion and its activity depends on: (1) the dose ofprolactin, (2) the type of the follicular layer secreting steroids, (3) the position of the follicle in the hierarchy and (4) the stage of the ovulatory cycle. Steroids 126-133 prolactin Gallus gallus 19-28 9645683-4 1998 We have examined adrenal steroid regulation of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and basic fibroblast growth factor, as well as the growth associated protein GAP-43, through activation of GR or mineralocorticoid receptor with selective agonists. Steroids 25-32 brain-derived neurotrophic factor Rattus norvegicus 65-98 9645683-4 1998 We have examined adrenal steroid regulation of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and basic fibroblast growth factor, as well as the growth associated protein GAP-43, through activation of GR or mineralocorticoid receptor with selective agonists. Steroids 25-32 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 223-225 9797757-7 1998 In contrast, c-fos-irm was present in all steroid naive subjects but in only two of the eight subjects treated with BDP (p = 0.007, two-tailed Fisher"s exact test). Steroids 42-49 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 3808848-2 1986 Eight children with steroid-response nephrotic syndrome were investigated to study the relation-ship between steroid responsive syndrome, allergy and HLA-antigens. Steroids 109-116 inositol polyphosphate-5-phosphatase D Homo sapiens 96-100 3758192-4 1986 Our present and previous data suggest that N exemplifies one class of anabolic steroids that become less androgenic due to 5 alpha-reduction, it shows high myotropic activity, M-A dissociation (= 7-30) and affinity to the androgen receptor. Steroids 79-87 androgen receptor Rattus norvegicus 222-239 3758193-0 1986 Assignment of anabolic-androgenic and antiandrogenic properties to some chlorine-substituted steroids on the basis of their binding characteristics to the androgen receptor of the rat seminal vesicle. Steroids 93-101 androgen receptor Rattus norvegicus 155-172 3463301-3 1986 Administration of this steroid to male rats in vivo results in the formation of three more-polar green pigments (GP2, 3 and 4). Steroids 23-30 glycoprotein 2 Rattus norvegicus 113-125 14652007-4 2003 We hypothesize that the GGC and CAG repeats in AR gene correspond to lower incidence of steroid-related cancers in the Japanese population. Steroids 88-95 gamma-glutamylcyclotransferase Homo sapiens 24-27 14560037-0 2003 Inhibition of adrenal cortical steroid formation by procaine is mediated by reduction of the cAMP-induced 3-hydroxy-3-methylglutaryl-coenzyme A reductase messenger ribonucleic acid levels. Steroids 31-38 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Mus musculus 106-153 3010286-5 1986 The density of specific binding sites in membranes obtained from several organs from the rhesus monkey is consistent with the hypothesis that corticosteroid-binding globulin is involved in the transport of steroid hormones into target tissues. Steroids 206-222 serpin family A member 6 Macaca mulatta 142-173 14714827-1 2003 PURPOSE: The sex steroid control of the endometrial cycle is mediated by transcription factors, four of which are the estrogen and progesterone receptors, c-jun and c-fos, all expressed by the endometrium. Steroids 17-24 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 155-160 14714827-1 2003 PURPOSE: The sex steroid control of the endometrial cycle is mediated by transcription factors, four of which are the estrogen and progesterone receptors, c-jun and c-fos, all expressed by the endometrium. Steroids 17-24 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 165-170 2939310-1 1986 Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Steroids 42-49 glucose-6-phosphate dehydrogenase Homo sapiens 118-151 2939310-1 1986 Dehydroepiandrosterone (DHEA), an adrenal steroid of no known biological function, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Steroids 42-49 glucose-6-phosphate dehydrogenase Homo sapiens 153-158 3948788-0 1986 Steroids and triiodothyronine reduce nerve growth factor concentrations in medium conditioned by L-929 fibroblasts. Steroids 0-8 nerve growth factor Mus musculus 37-56 3948788-2 1986 In this study we tested the effects of thyroid hormone and steroids on NGF levels in medium conditioned by L-929 fibroblasts (L-cells), a mouse cell line that secretes NGF in culture. Steroids 59-67 nerve growth factor Mus musculus 71-74 14632460-4 2003 The steroids binding to CBG were used as a benchmark series where biological activity is limited by shape factors. Steroids 4-12 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 24-27 3455692-6 1986 Each steroid tested, including delta 5-3 beta-hydroxysteroids, estrogens, and several delta 4-3-ketosteroids, with the exception of cortisol, caused significant inhibition of 3 beta-HSD activity, and in each case the steroid appeared to behave as a competitive inhibitor. Steroids 53-60 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 175-185 12960018-3 2003 In some neurons, steroid metabolites known as neurosteroids modulate the function of the GABAA receptor. Steroids 17-24 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 89-94 3455692-7 1986 In most cases the Ki value was approximately 10(-7) M. At micromolar concentrations several steroids, notably estrone and estradiol, caused almost total inhibition of adrenal 3 beta-HSD activity. Steroids 92-100 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 175-185 3455692-8 1986 Comparison of the calculated Ki values with available data concerning changes in intra-adrenal steroid concentrations during childhood suggests that these changes would be sufficient to cause a relative decline in 3 beta-HSD activity during adrenarche. Steroids 95-102 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 214-224 3455692-9 1986 Although postnatal circulating steroid concentrations would appear to be insufficient to influence adrenal steroidogenesis, the high serum levels of placental steroids during fetal life would be expected to cause marked 3 beta-HSD inhibition. Steroids 159-167 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 220-230 3485169-3 1986 The exchange of the bound steroids occurred by 24-48 h at 0 degree C, suggesting that most of the nuclear androgen receptor was occupied. Steroids 26-34 androgen receptor Mus musculus 106-123 3486322-9 1986 These indices might be of predictive value to determine whether these steroids exert their anabolic action in muscle through the glucocorticoid receptor or through the androgen receptor. Steroids 70-78 androgen receptor Rattus norvegicus 168-185 12960058-1 2003 Experimental evidence suggested that secretion of steroid hormones from adrenocortical cells involves carrier-mediated transport: Cortisol release from, and uptake of p-[3H]aminohippurate into, bovine adrenocortical cells showed properties of the renal p-[3H]aminohippurate/anion exchanger OAT1. Steroids 50-57 solute carrier family 22 member 6 Rattus norvegicus 290-294 3770534-10 1986 This finding indicates that the mechanism of action of these inhibitory steroids is likely through an effect on 3 beta-HSD activity and not due to a change in the rate of enzyme synthesis. Steroids 72-80 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 112-122 14614213-5 2003 From these findings, we hypothesized that the substance had the structure of a C-19 steroid with two hydroxyl groups at positions C-3 and C-11, one keto-group at C-17 and a double bond between C-4 and C-5 of the A ring. Steroids 84-91 complement C3 Homo sapiens 130-133 14614213-5 2003 From these findings, we hypothesized that the substance had the structure of a C-19 steroid with two hydroxyl groups at positions C-3 and C-11, one keto-group at C-17 and a double bond between C-4 and C-5 of the A ring. Steroids 84-91 aldo-keto reductase family 1 member C4 Homo sapiens 138-142 4084295-1 1985 The kinetics of steroid binding to rat liver glucocorticoid receptor (GR) and receptor denaturation were dependent upon the nature of the molecule occupying GR. Steroids 16-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 45-68 14756022-6 2003 The 50 pregnant women with GER symptoms heartburn, acid regurgitations had increased levels of steroid hormones. Steroids 95-102 GER Homo sapiens 27-30 4084295-1 1985 The kinetics of steroid binding to rat liver glucocorticoid receptor (GR) and receptor denaturation were dependent upon the nature of the molecule occupying GR. Steroids 16-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 70-72 4084295-1 1985 The kinetics of steroid binding to rat liver glucocorticoid receptor (GR) and receptor denaturation were dependent upon the nature of the molecule occupying GR. Steroids 16-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 157-159 4063391-3 1985 The new glucocorticoid-binding protein, Peak C, was characterized by Scatchard analysis and competition with other steroids as a glucocorticoid receptor. Steroids 115-123 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 129-152 12775713-7 2003 The binding of DHEA to MAP2C involved specific hydrogen bonds that orient the steroid into the pocket. Steroids 78-85 microtubule associated protein 2 Homo sapiens 23-28 3937588-7 1985 Thus, increased CKBB activity can serve as an additional characteristic marker for the action of steroid and polypeptide hormones and for prostaglandins. Steroids 97-104 creatine kinase B Rattus norvegicus 16-20 12899845-1 2003 The estrogenic steroid hormones, acting primarily through the nuclear estrogen receptors ERalpha and ERbeta, regulate sexual differentiation in a wide variety of vertebrates. Steroids 15-22 estrogen receptor 1 L homeolog Xenopus laevis 89-96 12899845-1 2003 The estrogenic steroid hormones, acting primarily through the nuclear estrogen receptors ERalpha and ERbeta, regulate sexual differentiation in a wide variety of vertebrates. Steroids 15-22 estrogen receptor 1 L homeolog Xenopus laevis 101-107 3876336-2 1985 Following steroid deprivation, androgens specifically increase the concentration of their receptors in these cells by approximately 2-fold within 6 h and 3-4-fold in 24 h. In the presence of potent glucocorticoids, androgen receptor augmentation is reduced by 40-50% in the first 6 h and completely inhibited during the subsequent 24 h. This event, which is specific for glucocorticoids, appears to be due to an inhibition of androgen receptor synthesis. Steroids 10-17 androgen receptor Rattus norvegicus 215-232 12834435-3 2003 The aim of the present study was to analyse NKB mRNA expression at a crucial time when the steroid has stimulated the pathways leading to the induction of these two events. Steroids 91-98 tachykinin-3 Ovis aries 44-47 12764078-10 2003 The steroid hormone antagonist RU486 blocked the effect of dexamethasone on mUcn II mRNA expression and promoter activation, suggesting a direct glucocorticoid receptor-mediated effect of dexamethasone on mUcn II mRNA expression. Steroids 4-19 urocortin 2 Mus musculus 76-83 4068702-4 1985 Steroid specificity, sedimentation analysis and equilibrium association constants indicated that this exchange assay labels the androgen receptor without interference from other prostatic steroid binding proteins. Steroids 0-7 androgen receptor Rattus norvegicus 128-145 12764078-10 2003 The steroid hormone antagonist RU486 blocked the effect of dexamethasone on mUcn II mRNA expression and promoter activation, suggesting a direct glucocorticoid receptor-mediated effect of dexamethasone on mUcn II mRNA expression. Steroids 4-19 urocortin 2 Mus musculus 205-212 4068702-4 1985 Steroid specificity, sedimentation analysis and equilibrium association constants indicated that this exchange assay labels the androgen receptor without interference from other prostatic steroid binding proteins. Steroids 188-195 androgen receptor Rattus norvegicus 128-145 4043925-4 1985 Structural modifications at C-17 of a steroid molecule involving esterification, epimerization or reduction of the 17 beta-hydroxyl group, or introduction of a bulky 17 alpha group have the effect of decreasing the SHBG binding affinity of the steroid molecule. Steroids 244-251 sex hormone binding globulin Bos taurus 215-219 12939667-2 2003 OBJECTIVE: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) are the most abundant steroids in human plasma. Steroids 89-97 sulfotransferase family 2A member 1 Homo sapiens 59-65 3891759-6 1985 The low molecular weight pupal cuticle proteins accumulate in response to a pulse of the insect steroid hormone 20-hydroxyecdysone and begin to appear 6 h after the withdrawal of the hormone from the culture medium. Steroids 96-111 Partner of Bursicon Drosophila melanogaster 25-30 14979123-2 2003 Specific immuno-therapy (SIT) and steroid treated patients showed significantly lower ECP levels and higher methacholine PD20 FEV1 than untreated patients, during all years of the study. Steroids 34-41 ribonuclease A family member 3 Homo sapiens 86-89 14979123-3 2003 During the first two years, spring ECP increase was higher in SIT treated patients than in steroid ones, however no significant differences were found during the following years. Steroids 91-98 ribonuclease A family member 3 Homo sapiens 35-38 2983900-1 1985 Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. Steroids 53-60 glucose-6-phosphate dehydrogenase Homo sapiens 126-159 12858014-1 2003 The enzyme complex 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4-isomerase (3beta-HSD) is involved in the biosynthesis of all classes of active steroids. Steroids 147-155 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 79-88 2983900-1 1985 Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. Steroids 53-60 glucose-6-phosphate dehydrogenase Homo sapiens 161-166 12621105-12 2003 Interestingly, when a complete course of antenatal steroids was given, BDNF and NT3 cord blood levels were higher than when no steroid was given. Steroids 51-59 brain derived neurotrophic factor Homo sapiens 71-75 3977896-1 1985 The genes for seminal vesicle secretory protein IV and prostate steroid binding protein component 3 of the rat share upstream homologies of which the most striking is a 30 nucleotide sequence located between position -190 and -330 relative to the major transcriptional initiation sites. Steroids 64-71 seminal vesicle secretory protein 4 Rattus norvegicus 14-50 12621105-12 2003 Interestingly, when a complete course of antenatal steroids was given, BDNF and NT3 cord blood levels were higher than when no steroid was given. Steroids 51-59 neurotrophin 3 Homo sapiens 80-83 12621105-12 2003 Interestingly, when a complete course of antenatal steroids was given, BDNF and NT3 cord blood levels were higher than when no steroid was given. Steroids 51-58 brain derived neurotrophic factor Homo sapiens 71-75 12621105-12 2003 Interestingly, when a complete course of antenatal steroids was given, BDNF and NT3 cord blood levels were higher than when no steroid was given. Steroids 51-58 neurotrophin 3 Homo sapiens 80-83 3965467-5 1985 In this paper we show that NADPH-dependent conversion of the rat liver glucocorticoid receptor from a nonbinding to a steroid-binding form is blocked in an immune-specific manner by antisera raised against purified rat liver thioredoxin reductase or thioredoxin. Steroids 118-125 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 71-94 3015752-0 1985 Histochemical reactions of arylosulphatases and beta-glucuronidase in the intestinal epithelium in rats under conditions of changed ACTH and steroid hormones level. Steroids 141-157 glucuronidase, beta Rattus norvegicus 48-66 12665606-2 2003 In skeletal muscle of pregnant animals, nNOS mRNA is upregulated, suggesting that muscle nNOS expression is modulated by the steroid hormone oestrogen. Steroids 125-140 nitric oxide synthase 1 Rattus norvegicus 40-44 12665606-2 2003 In skeletal muscle of pregnant animals, nNOS mRNA is upregulated, suggesting that muscle nNOS expression is modulated by the steroid hormone oestrogen. Steroids 125-140 nitric oxide synthase 1 Rattus norvegicus 89-93 6433897-0 1984 Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats. Steroids 11-27 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 75-102 12713999-2 2003 In this study we have analyzed the effects of the female sex steroids estrogen and progesterone on matrix metalloproteinases (MMP-9 and -2) production in primary EC cells and EC cell lines. Steroids 61-69 matrix metallopeptidase 9 Homo sapiens 126-138 14610315-7 2003 The factor responsible for the upregulation of epiglycanin is heat stable and can be removed from ascites fluids by activated charcoal, suggesting that it is a steroid. Steroids 160-167 mucin 21 Mus musculus 47-58 6433897-6 1984 In contrast, 4-nitrophenol UDP-glucuronosyltransferase activity was not affected by steroid hormones, but was highly induced by 3-methylcholanthrene. Steroids 84-100 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 27-54 6547722-10 1984 However, the steroid did result in an enrichment of the proportion of calmodulin and its two binding proteins associated with the nuclear matrix within 4 h after injection. Steroids 13-20 calmodulin 2 Gallus gallus 70-80 12667619-3 2003 The actions of adrenomedullin and PAMP on adrenal steroid secretion were determined by measuring the aldosterone, cortisol and dehydroepiandrosterone (DHEA) content of cell culture medium after exposure of the human adrenal H295R cells to either PAMP or adrenomedullin. Steroids 50-57 adrenomedullin Homo sapiens 15-29 12667619-5 2003 These data suggest that both adrenomedullin and PAMP may be autocrine regulators of adrenal steroid secretion. Steroids 92-99 adrenomedullin Homo sapiens 29-43 6547722-12 1984 Taken together, these data are compatible with a role for calmodulin and myosin light chain kinase in the response of chicken liver cells to steroid hormones. Steroids 141-157 calmodulin 2 Gallus gallus 58-68 6466649-6 1984 The results support the hypothesis that the 8S steroid receptor is a complex of the activated 4.5S androgen receptor with a non-steroid binding protein that renders the receptor incapable of binding in nuclei. Steroids 47-54 androgen receptor Rattus norvegicus 99-116 12654006-7 2003 Interestingly, Tgl1p, a potential ester hydrolase, was found to enhance steroid productivity, probably through both the availability and/or the trafficking of the CYP11A1 substrate. Steroids 72-79 sterol esterase Saccharomyces cerevisiae S288C 15-20 6744734-4 1984 This suggests that calmodulin mediates steroid effects on the collagen matrix as well as on calcium homeostasis. Steroids 39-46 calmodulin Oryctolagus cuniculus 19-29 12525486-0 2003 Glucocorticoid down-regulation of RhoA is required for the steroid-induced organization of the junctional complex and tight junction formation in rat mammary epithelial tumor cells. Steroids 59-66 ras homolog family member A Rattus norvegicus 34-38 12732287-1 2003 In human prostate cancer cells, the availability of the steroid hormone 1,25-dihydroxyvitamin D(3) for antimitotic action is determined through the activity of the two enzymes CYP24 and CYP27B1, viz. Steroids 56-71 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 176-181 6744734-5 1984 Diminished calmodulin levels in weight-bearing cartilage of steroid-treated animals has as yet unresolved significance. Steroids 60-67 calmodulin Oryctolagus cuniculus 11-21 6540703-0 1984 Effect of some selected anti-inflammatory steroids on elastin content in liver of rats treated with carbon tetrachloride. Steroids 42-50 elastin Rattus norvegicus 54-61 12740512-7 2003 We also found increased concentrations of vitronectin in patients with clinical deterioration compared to those remaining stable and in ex-smokers compared to non-smokers and, increased vitronectin and ET-1 in patients treated with steroids compared to untreated patients. Steroids 232-240 vitronectin Homo sapiens 186-197 6540703-2 1984 The influence of anti-inflammatory steroids (hydrocortisone, prednisone, dexamathasone) upon elastin content in liver was investigated in healthy and CCl4 intoxicated rats. Steroids 35-43 elastin Rattus norvegicus 93-100 6540703-4 1984 A decrease of elastin content after steroid treatment was also found in rats with injured liver, as compared to animals receiving CCl4 only. Steroids 36-43 elastin Rattus norvegicus 14-21 6366788-7 1984 After a single dose of testosterone, renal OrnDCase mRNA concentration increased as soon as 6 hr and peaked 24 hr after steroid injection, as measured by RNA blot hybridization. Steroids 120-127 ornithine decarboxylase, structural 1 Mus musculus 43-51 6236762-6 1984 During the post CSF diet period all the steroids showed a tendency toward the control values. Steroids 40-48 colony stimulating factor 2 Rattus norvegicus 16-19 12586500-1 2003 A new agglomerated KSR-592 (steroid) beta-form needle-like crystals with lactose system for dry powder inhalation (DPI) was developed to improve inhalation performance with Jethaler. Steroids 28-35 kinase suppressor of ras 1 Rattus norvegicus 19-22 12604225-8 2003 This difference in steroid binding provides a structural basis for the broad positional specificity of AKR1C2 and the exquisite stereospecificity of AKR1C9. Steroids 19-26 aldo-keto reductase family 1, member C14 Rattus norvegicus 149-155 12604226-0 2003 Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9). Steroids 0-7 aldo-keto reductase family 1, member C14 Rattus norvegicus 75-110 12604226-0 2003 Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9). Steroids 0-7 aldo-keto reductase family 1, member C14 Rattus norvegicus 112-122 9678543-6 1998 Serum DHEAS concentrations were 10-fold higher in the rats given the steroid by gavage or in the diet compared with levels in control rats. Steroids 69-76 sulfotransferase family 2A member 1 Homo sapiens 6-11 9614204-1 1998 The rat UDP glucuronosyltransferase, UGT2B1, is expressed in the liver where it glucuronidates steroids, environmental toxins, and carcinogens. Steroids 95-103 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 8-35 12604226-0 2003 Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9). Steroids 0-7 aldo-keto reductase family 1, member C14 Rattus norvegicus 126-132 12604226-1 2003 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, plays a pivotal role in the inactivation of circulating steroid hormones. Steroids 181-197 aldo-keto reductase family 1, member C14 Rattus norvegicus 10-45 12604226-1 2003 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, plays a pivotal role in the inactivation of circulating steroid hormones. Steroids 181-197 aldo-keto reductase family 1, member C14 Rattus norvegicus 47-57 9593106-7 1998 At 10 microM, (+)-DHP and (+)-ACN depressed excitatory responses in a bicuculline-sensitive fashion, suggesting that direct chloride channel gating by the steroids contributed to the depression. Steroids 155-163 dihydropyrimidinase Rattus norvegicus 18-21 6356183-6 1983 Although alpha-MSH may stimulate the secretion of an adrenal steroid that blocks the facilitatory action of progesterone on female sexual behaviour the present results suggest that this inhibitory effect could be mediated by a catecholamine. Steroids 61-68 proopiomelanocortin Rattus norvegicus 9-18 9593740-1 1998 The glucocorticoid receptor (GR) HBD must be bound to the protein chaperone hsp90 in order to acquire the high affinity steroid binding conformation. Steroids 120-127 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 4-27 9593740-1 1998 The glucocorticoid receptor (GR) HBD must be bound to the protein chaperone hsp90 in order to acquire the high affinity steroid binding conformation. Steroids 120-127 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 29-31 12604226-1 2003 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, plays a pivotal role in the inactivation of circulating steroid hormones. Steroids 181-197 aldo-keto reductase family 1, member C14 Rattus norvegicus 61-67 6883207-5 1983 Coproporphyrin was the major porphyrin to accumulate in response to allylisopropylacetamide, aromatic amides, and steroids, a result suggesting inhibition of coproporphyrinogen oxidase. Steroids 114-122 coproporphyrinogen oxidase Gallus gallus 158-184 12563018-8 2003 Stepwise assembly experiments have shown that hsp70 and hsp40 first interact with the receptor in an ATP-dependent reaction to produce a receptor*hsp70*hsp40 complex that is "primed" to be activated to the steroid-binding state in a second ATP-dependent step with hsp90, Hop, and p23. Steroids 206-213 heat shock protein family A (Hsp70) member 4 Homo sapiens 46-51 12563018-8 2003 Stepwise assembly experiments have shown that hsp70 and hsp40 first interact with the receptor in an ATP-dependent reaction to produce a receptor*hsp70*hsp40 complex that is "primed" to be activated to the steroid-binding state in a second ATP-dependent step with hsp90, Hop, and p23. Steroids 206-213 heat shock protein family A (Hsp70) member 4 Homo sapiens 146-151 9593740-10 1998 Thus, a region of GR that has not been thought to be relevant for hsp90 binding is now seen to be of critical importance, and these data argue strongly against the commonly accepted model of receptor-hsp90 heterocomplex assembly in which the chaperone initially interacts nonspecifically with hydrophobic regions of the partially denatured HBD and subsequently assists its folding to the steroid binding confirmation. Steroids 388-395 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 18-20 9564837-0 1998 Regulation of cyclooxygenase-2 and prostaglandin F synthase gene expression by steroid hormones and interferon-tau in bovine endometrial cells. Steroids 79-95 prostaglandin-endoperoxide synthase 2 Bos taurus 14-30 6601026-5 1983 The steroid also suppressed CSF-independent [3H]thymidine uptake, but the time course of suppression obviously differed from that of CSF-dependent uptake. Steroids 4-11 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 28-31 11326954-0 1998 [Study on HSP70, 90 mRNA gene expression in peripheral blood mononuclear cells with steroid-resistant asthmatics]. Steroids 84-91 heat shock protein family A (Hsp70) member 4 Homo sapiens 10-15 11326954-1 1998 OBJECTIVE: To investigate the role of heat shock protein(HSP) 70, 90 alpha, 90 beta mRNA on the pathogenesis of steroid-resistant(SR) asthma. Steroids 112-119 heat shock protein family A (Hsp70) member 4 Homo sapiens 38-83 11326954-3 1998 With reverse transcription-polymerase chain reaction(RT-PCR), the expression of hsp70, 90 alpha, 90 beta mRNA were detected in peripheral blood mononuclear cell(PMBC) from normal volunteers and SR. steroid-sensitive(SS) asthmatics. Steroids 198-205 heat shock protein family A (Hsp70) member 4 Homo sapiens 80-104 12509270-5 2003 This adrenal expression pattern is consistent with a requirement for polkappa for the replicative bypass of DNA base damage generated during steroid biosynthesis. Steroids 141-148 DNA polymerase lambda Homo sapiens 69-77 12589253-1 2003 In vitro studies using biochemical, pharmacological and molecular approaches demonstrated that the peripheral-type benzodiazepine receptor (PBR) is a mitochondrial protein, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 306-313 translocator protein Homo sapiens 99-138 12589253-1 2003 In vitro studies using biochemical, pharmacological and molecular approaches demonstrated that the peripheral-type benzodiazepine receptor (PBR) is a mitochondrial protein, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 306-313 translocator protein Homo sapiens 140-143 12589253-3 2003 Targeted disruption of the PBR gene in Leydig cells resulted in the arrest of cholesterol transport into mitochondria and steroid formation. Steroids 122-129 translocator protein Homo sapiens 27-30 6822514-8 1983 These results are interpreted to indicate that "backwards binding" is an important feature of the binding of steroids to delta 5-3-ketosteroid isomerase. Steroids 109-117 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 121-152 12424224-1 2003 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 1, nephrin Mus musculus 13-18 12424224-1 2003 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 2, podocin Mus musculus 22-27 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 87-95 sulfotransferase family 2A member 1 Homo sapiens 58-63 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 175-183 sulfotransferase family 2A member 1 Homo sapiens 58-63 9539798-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate derivative (DHEAS) are the most abundant steroids produced by the human adrenal, but no receptors have been identified for these steroids, and no function for them has been established, other than as precursors for sex steroid synthesis. Steroids 87-94 sulfotransferase family 2A member 1 Homo sapiens 58-63 9539798-9 1998 These studies provide evidence of mechanisms by which DHEA and DHEAS exert biological actions, show that they have specific functions other than as sex steroid precursors, mediate their effects via non-classic steroid hormone receptors, and suggest that their developmentally regulated synthesis in vivo may play crucial and different roles in organizing the neocortex. Steroids 152-159 sulfotransferase family 2A member 1 Homo sapiens 63-68 9628300-6 1998 ANP concentrations were higher in the meconium than in the control group throughout the study and further increased after steroid treatment with a good correlation to ET-1 (r = 0.86). Steroids 122-129 endothelin-1 Sus scrofa 167-171 12424224-1 2003 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 1, nephrin Mus musculus 85-92 12424224-1 2003 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 2, podocin Mus musculus 97-104 6552849-0 1983 Sodium-retaining steroids increase parotid salivary kallikrein. Steroids 17-25 kallikrein related peptidase 4 Homo sapiens 52-62 9631691-4 1998 More studies in this field are needed to evaluate the effect of specific immunotherapy and/or prolonged topical steroid therapy on the kinetics of ECP liberation after allergen challenge. Steroids 112-119 ribonuclease A family member 3 Homo sapiens 147-150 9795757-0 1998 Effect of pregnancy and steroid hormones on plasma adrenomedullin levels in the rat. Steroids 24-40 adrenomedullin Rattus norvegicus 51-65 6822414-3 1983 In addition, altered steroid induction of hepatic PEPCK was examined in adrenalectomized mice given dexamethasone at intervals before and after a median lethal dose of endotoxin. Steroids 21-28 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 50-55 9543154-6 1998 Unlike purified IDBP, hsc-70 and hsp-70 were also competent binders of the gonadal steroid 17beta-estradiol (mean Kd for 25OHD3, 2.5 and 6.6 nmol/L by hsc-70 and hsp-70, respectively), but not of two other gonadal hormones, progesterone and testosterone. Steroids 83-90 heat shock protein family A (Hsp70) member 4 Homo sapiens 33-39 12223450-6 2002 In steroid-sensitive patients, activation of NF-kappaB, AP-1, p38, and JNK was mainly found in lamina propria macrophages. Steroids 3-10 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 56-60 9540976-0 1998 Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones. Steroids 146-162 tyrosinase Homo sapiens 18-28 6621360-1 1983 Steroids that inhibit glucose-6-phosphate dehydrogenase (G6PD) were used to examine the correlation between the loss of GSSG-reducing activity and G6PD deficiency in the lens. Steroids 0-8 glucose-6-phosphate dehydrogenase Homo sapiens 22-55 12454632-4 2002 Antenatal administration of repeated courses compared with single course of steroids improves fetal lung function with a decrease of RDS notably if the children is born before 28 weeks of gestation (NP 2) but numerous animal studies reported adverse effects of repeated courses. Steroids 76-84 peripherin 2 Homo sapiens 133-136 12454632-4 2002 Antenatal administration of repeated courses compared with single course of steroids improves fetal lung function with a decrease of RDS notably if the children is born before 28 weeks of gestation (NP 2) but numerous animal studies reported adverse effects of repeated courses. Steroids 76-84 neuropilin 2 Homo sapiens 199-203 12454632-5 2002 Several studies in women having received of repeated courses steroids report a decrease in birth weight and head circumference at birth but with a 3 years follow up similar to that of children exposed to a single course (NP 3). Steroids 61-69 leukemia NUP98 fusion partner 1 Homo sapiens 221-225 9635292-11 1998 GHR gene expression is also regulated by factors such as nutritional intake, GH, steroid hormones, and diabetes mellitus. Steroids 81-97 growth hormone receptor Homo sapiens 0-3 6621360-1 1983 Steroids that inhibit glucose-6-phosphate dehydrogenase (G6PD) were used to examine the correlation between the loss of GSSG-reducing activity and G6PD deficiency in the lens. Steroids 0-8 glucose-6-phosphate dehydrogenase Homo sapiens 57-61 6891012-6 1982 On the other hand, the relative myotropic activity in vivo of these steroids is apparently determined by the ratio of their affinities (N/T approximately 3 at 37 degrees C) to the androgen receptor. Steroids 68-76 androgen receptor Rattus norvegicus 180-197 9560101-10 1998 In subjects with allergic chronic sinusitis treated with topical corticosteroids, the expression of interleukin-4 receptor and interleukin-5 receptor messenger RNA levels was significantly lower than levels in patients with allergic chronic sinusitis who were not taking topical steroids (p < 0.001, p < 0.001). Steroids 72-80 interleukin 4 receptor Homo sapiens 100-122 12359070-1 2002 The essential gene product Prp45 (379 aa) of Saccharomyces cerevisiae is a highly conserved, but N-terminally abridged, ortholog of the human transcriptional coactivator SKIP, which is involved in TGFbeta, Notch, and steroid hormone signaling. Steroids 217-232 mRNA splicing protein PRP45 Saccharomyces cerevisiae S288C 27-32 7130193-1 1982 We have examined the effects of steroid hormones in the chromatin sensitivity of the ovalbumin gene to micrococcal nuclease and have attempted to define the importance of the nucleosome core, higher order chromatin folding, and transcription in the maintenance of the nuclease-sensitive conformation of the ovalbumin chromatin. Steroids 32-39 ovalbumin (SERPINB14) Gallus gallus 85-94 12213069-0 2002 Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR). Steroids 55-62 translocator protein Rattus norvegicus 156-159 9630045-0 1998 HLA-DQB1 and DRB1 alleles in Egyptian children with steroid-sensitive nephrotic syndrome. Steroids 52-59 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 0-8 7166157-0 1982 Steroid-binding properties of the androgen receptor of rat seminal vesicle. Steroids 0-7 androgen receptor Rattus norvegicus 34-51 9539145-1 1998 Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man. Steroids 64-71 sulfotransferase family 2A member 1 Homo sapiens 32-37 12213069-1 2002 In the present study, we have synthesized and tested novel pyridopyrrolo- and pyrrolobenzoxazepine derivatives, as novel and selective peripheral type benzodiazepine receptor (PBR) ligands, and their ability to modulate steroid biosynthesis has been investigated. Steroids 220-227 translocator protein Rattus norvegicus 135-174 12213069-1 2002 In the present study, we have synthesized and tested novel pyridopyrrolo- and pyrrolobenzoxazepine derivatives, as novel and selective peripheral type benzodiazepine receptor (PBR) ligands, and their ability to modulate steroid biosynthesis has been investigated. Steroids 220-227 translocator protein Rattus norvegicus 176-179 7166157-1 1982 The binding of 19 steroids to the vesicular androgen receptor has been studied under cell-free conditions. Steroids 18-26 androgen receptor Rattus norvegicus 44-61 12183045-6 2002 Therefore, while acute MC treatment stimulated the activity of pre-existing enzyme, chronic steroid treatment recruited additional neurons showing nNOS immunoreactivity/NADPH-d activity. Steroids 92-99 nitric oxide synthase 1 Rattus norvegicus 147-151 9545554-1 1998 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroids in humans, and their serum concentrations progressively decrease with age. Steroids 77-85 sulfotransferase family 2A member 1 Homo sapiens 47-53 6181503-0 1982 Immunochemical analysis of the glucocorticoid receptor: identification of a third domain separate from the steroid-binding and DNA-binding domains. Steroids 107-114 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 31-54 9473310-1 1998 The intracellular concentration of many steroids and xenobiotics is influenced by the membrane protein P-glycoprotein (Pgp). Steroids 40-48 phosphoglycolate phosphatase Mus musculus 103-117 9473310-1 1998 The intracellular concentration of many steroids and xenobiotics is influenced by the membrane protein P-glycoprotein (Pgp). Steroids 40-48 phosphoglycolate phosphatase Mus musculus 119-122 12196470-4 2002 We determined whether steroid hormones would modulate the expression of GAD in pancreatic beta-cells. Steroids 22-38 glutamate decarboxylase 1 Homo sapiens 72-75 12208668-0 2002 Influence of steroids and GnRH on biosynthesis and secretion of secretogranin II and chromogranin A in relation to LH release in LbetaT2 gonadotroph cells. Steroids 13-21 secretogranin II Mus musculus 64-80 6181503-9 1982 The immunoactive domain could be separated from the half of the glucocorticoid receptor containing the steroid-binding and the DNA-binding domains (Stokes radius, 3.3 nm), by limited proteolysis of the receptor by alpha-chymotrypsin followed by gel filtration or chromatography on DNA-cellulose. Steroids 103-110 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 64-87 9533818-3 1998 In all instances, the steroid-induced exportation of LC1 was unaffected by brefeldin A (1.4 microM), monensin (10 microM) and nocodazole (3.3 microM); however, these drugs readily blocked the release of corticotrophin from pituitary tissue. Steroids 22-29 annexin A1 Homo sapiens 53-56 6277533-2 1982 Antiserum was elicited in the rabbit by immunization with antigen in which the sulfated steroid hapten is linked to a carrier protein through the C-6 position. Steroids 88-95 LOW QUALITY PROTEIN: complement component C6 Oryctolagus cuniculus 146-149 9489701-3 1998 PXR exists as two isoforms, PXR.1 and PXR.2, that are differentially activated by steroids. Steroids 82-90 peroxisomal biogenesis factor 5 like Homo sapiens 38-43 9445307-7 1998 The ability of steroids to inhibit pro-inflammatory cytokines but to enhance the anti-inflammatory cytokine such as IL-10 may contribute to their beneficial actions in asthma. Steroids 15-23 interleukin 10 Homo sapiens 116-121 12208668-0 2002 Influence of steroids and GnRH on biosynthesis and secretion of secretogranin II and chromogranin A in relation to LH release in LbetaT2 gonadotroph cells. Steroids 13-21 chromogranin A Mus musculus 85-99 6174971-3 1981 Glucocorticoids including dexamethasone, betamethasone, and cortisone, all of which are inhibitors of phospholipase A2, blocked induction of the dioxygenase by interferon in the nanomolar range, whereas other steroid hormones, such as aldosterone, testosterone, and 17 beta-estradiol, were all but ineffective. Steroids 209-216 phospholipase A2, group IB, pancreas Mus musculus 102-118 12153977-6 2002 In contrast, subjects with asthma treated with inhaled steroids were found to have greater HDAC activity than untreated subjects with asthma, although still lower than control subjects. Steroids 55-63 histone deacetylase 9 Homo sapiens 91-95 12153977-9 2002 The increase in HAT activity and reduced HDAC activity in asthma may underlie the increased expression of multiple inflammatory genes, and this is reversed, at least in part, by treatment with inhaled steroids. Steroids 201-209 histone deacetylase 9 Homo sapiens 41-45 9444968-8 1998 In conclusion, this study shows that the effects of DHEA/DHEA-S on osteoblastic cell growth and differentiation are likely to be mediated via an effect on 1,25(OH)2D3-induced changes in bone cells, suggesting a distinctive role for these steroids in the regulation of bone metabolism. Steroids 238-246 sulfotransferase family 2A member 1 Homo sapiens 52-63 6976242-2 1981 We purified C1INH from the plasmas of one such patient before and during treatment with the anabolic steroid stanozolol. Steroids 101-108 serpin family G member 1 Homo sapiens 12-17 9405411-1 1997 To evaluate the role of the mitochondrial peripheral-type benzodiazepine receptor (PBR) in steroidogenesis, we developed a molecular approach based on the disruption of the PBR gene, by homologous recombination, in the constitutive steroid producing R2C rat Leydig tumor cell line. Steroids 91-98 translocator protein Rattus norvegicus 83-86 9405411-4 1997 Although mitochondria from the PBR-negative cells contained high levels of the constitutively expressed 30-kDa steroidogenic activity regulator protein, these cells produced minimal amounts of steroids compared with normal cells (5%). Steroids 193-201 translocator protein Rattus norvegicus 31-34 12189366-2 2002 The exogenous female sex steroid hormones used in oral contraceptives are believed to significantly inhibit CYP2C19 activity. Steroids 25-32 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 108-115 6270154-1 1981 TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells. Steroids 87-94 calmodulin 2 Mus musculus 179-189 12130567-8 2002 These results indicate that CBP expression in developing rat brain is sexually dimorphic and an important modulator for steroid hormone action. Steroids 120-135 CREB binding protein Rattus norvegicus 28-31 12071853-8 2002 The relative activity of UGT2B30 in comparison with other simian UGT2B isoforms, as well as its large variety of substrates, strongly suggest that this enzyme is essential to inactivation of several steroids. Steroids 199-207 uDP-glucuronosyltransferase 2B30 Macaca fascicularis 25-32 9405411-6 1997 Addition of the hydrosoluble cholesterol derivative, 22R-hydroxycholesterol, increased steroid production by the PBR-negative R2C cells, indicating that the cholesterol transport mechanism was impaired. Steroids 87-94 translocator protein Rattus norvegicus 113-116 9403223-6 1997 Steroid administration affects PBR density, whereas depletion of hormones by hypophysectomy in female rats, or castration (surgical or chemical) in male rats, decreases PBR density in endocrine organs, which can be elevated to normal values after administration of the appropriate hormone. Steroids 0-7 translocator protein Rattus norvegicus 31-34 6270154-1 1981 TWO APPROACHES WERE USED TO STUDY THE POSSIBLE ROLE OF CALMODULIN IN THE REGULATION OF STEROID SYNTHESIS BY MOUSE ADRENAL TUMOR CELLS: trifluoperazine was used as an inhibitor of calmodulin and liposomes were used to deliver calmodulin into the cells. Steroids 87-94 calmodulin 2 Mus musculus 225-235 6270154-3 1981 When calmodulin is introduced into the cells via liposomes, steroid synthesis is slightly stimulated. Steroids 60-67 calmodulin 2 Mus musculus 5-15 12142225-6 2002 The reasons for these abnormal steroid feedback mechanisms may reside in sexually dimorphic inputs to the GnRH neurone, including those from oestrogen-receptive neurones in the arcuate nucleus that synthetize the neuropeptide, neurokinin B (NKB). Steroids 31-38 tachykinin-3 Ovis aries 227-239 6270154-6 1981 However, when both calmodulin and Ca(2+) are introduced via liposomes (either in separate liposomes or in the same liposomes), steroid synthesis is stimulated. Steroids 127-134 calmodulin 2 Mus musculus 19-29 12142225-6 2002 The reasons for these abnormal steroid feedback mechanisms may reside in sexually dimorphic inputs to the GnRH neurone, including those from oestrogen-receptive neurones in the arcuate nucleus that synthetize the neuropeptide, neurokinin B (NKB). Steroids 31-38 tachykinin-3 Ovis aries 241-244 9453377-6 1997 CONCLUSION: This study confirms the role of prematurity, low birth weight and RDS in the pathogenesis of ROP, and emphasises the importance of prenatal steroid prophylaxis of RDS in very preterm infants. Steroids 152-159 peripherin 2 Homo sapiens 175-178 6270154-9 1981 These observations suggest that calmodulin may be involved in regulating the transport of cholesterol to mitochondria, a process which is stimulated by ACTH and dibutyryl cyclic AMP and which may account, at least in part, for the increase in steroid synthesis produced by these agents. Steroids 243-250 calmodulin 2 Mus musculus 32-42 9298179-3 1997 We have previously demonstrated that deflazacort (a systemic steroid) reduces the expression of ICAM-1 on conjunctival epithelial cells. Steroids 61-68 intercellular adhesion molecule 1 Homo sapiens 96-102 7291040-0 1981 alpha-MSH at physiological concentrations stimulates "late pathway" steroid products in adrenal zona glomerulosa cells from sodium restricted rats. Steroids 68-75 proopiomelanocortin Rattus norvegicus 0-9 9261129-7 1997 We have shown that hsp90, p60, and hsp70 are sufficient for carrying out the folding change that converts the glucocorticoid receptor (GR) hormone binding domain (HBD) from a non-steroid binding to a steroid binding conformation, but to form stable GR.hsp90 heterocomplexes, p23 must also be present in the incubation mix (Dittmar, K. D., and Pratt, W. B. Steroids 200-207 heat shock protein family A (Hsp70) member 4 Homo sapiens 35-40 7291040-1 1981 alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. Steroids 21-28 proopiomelanocortin Rattus norvegicus 0-9 9247454-0 1997 Multiple doses of intravenous interleukin 10 in steroid-refractory Crohn"s disease. Steroids 48-55 interleukin 10 Homo sapiens 30-44 12153551-5 2002 In addition, CYP3A and UDPGT are catalysts of many reactions with endobiotics such as steroid hormones. Steroids 86-102 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 23-28 6974862-4 1981 Almost all the steroids inhibiting 3H-uridine incorporation into RNA, competed actively with triamcinolone acetonide, concerning thymocyte cytosol binding with glucocorticoid receptor. Steroids 15-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 160-183 12095499-1 2002 OBJECTIVE: To study the gonadal steroid responses to FSH and hCG in individuals with the inherited Finnish-type inactivating Ala189Val mutation of the FSH receptor gene. Steroids 32-39 follicle stimulating hormone receptor Homo sapiens 151-163 9532255-7 1997 Following treatment with a topical steroid (budesonide) there was a statistically significant increase of the levels of soluble IL-4 receptor. Steroids 35-42 interleukin 4 receptor Homo sapiens 128-141 9532255-9 1997 Topical steroids may possibly decrease inflammation by increasing the formation of soluble IL-4 receptor. Steroids 8-16 interleukin 4 receptor Homo sapiens 91-104 7245288-3 1981 The former in low concentration dissociates the steroid from the glucocorticoid receptor complex in relatively short time. Steroids 48-55 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 65-88 9274931-7 1997 Finally, the effect of the steroid on cytokine-induced ICAM-1 up-regulation was functionally related to its ability to suppress in vitro neutrophil trans-endothelial passage. Steroids 27-34 intercellular adhesion molecule 1 Homo sapiens 55-61 9265994-4 1997 After 4 days of steroid treatment, clinical improvement was associated with a decrease of sIL-2R (P < 0.003), ICAM-1 (P < 0.004), and ECP serum levels (P < 0.003), but ELAM-1 levels remained unchanged. Steroids 16-23 intercellular adhesion molecule 1 Homo sapiens 113-119 12077088-0 2002 Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn"s disease. Steroids 176-183 intercellular adhesion molecule 1 Homo sapiens 102-108 9265994-4 1997 After 4 days of steroid treatment, clinical improvement was associated with a decrease of sIL-2R (P < 0.003), ICAM-1 (P < 0.004), and ECP serum levels (P < 0.003), but ELAM-1 levels remained unchanged. Steroids 16-23 ribonuclease A family member 3 Homo sapiens 140-143 7214491-6 1981 Immunocytochemical staining with antibodies to rat PRL, human TSH beta and ovine LH beta revealed a population of steroid-concentrating cells that contained TSH and a second group that contained LH. Steroids 114-121 luteinizing hormone subunit beta Homo sapiens 81-88 9265994-5 1997 Both serum ECP and sIL-2R levels were significantly correlated with disease severity before as well as after steroid treatment. Steroids 109-116 ribonuclease A family member 3 Homo sapiens 11-14 9202234-11 1997 The pattern of steroid responses was retained in the presence of the c-Jun activator phorbol 12-myristate 13-acetate. Steroids 15-22 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 69-74 9202234-15 1997 These data indicate that opposing steroid influences can be mediated at the level of transcription through the AP-1 site and suggest that the integration of hormone action at this response element may underlie some of the opposing actions of estrogens and glucocorticoids or progestins on physiological responses. Steroids 34-41 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 111-115 12131614-9 2002 Trials with the anti-ICAM-1 antisense oligonucleotide, ISIS-2302, in steroid-refractory CD have provided conflicting efficacy data. Steroids 69-76 intercellular adhesion molecule 1 Homo sapiens 21-27 12044613-0 2002 Influence of gonadotropins on insulin- and insulin-like growth factor-I (IGF-I)-induced steroid production by bovine granulosa cells. Steroids 88-95 IGFI Bos taurus 73-78 6109446-0 1980 Role of somatostatin in the modulation of hypophysial growth hormone production by gonadal steroids. Steroids 91-99 somatostatin Homo sapiens 8-20 12070682-12 2002 Serum IL-10 levels in all patients correlated significantly inversely with hemoglobin levels (r=-0.50, P<0.05), total leukocytic count (TLC) (r=-0.58, P<0.01), and intra-articular steroid injection (r=+0.56, P<0.01). Steroids 186-193 interleukin 10 Homo sapiens 6-11 9215277-1 1997 The adrenal steroids, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), have attracted attention for their possible antiaging effects. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 69-74 7460859-0 1980 Changes in the cytoplasmic androgen receptor of rat ventral prostate after administration of androgens, antiandrogens and anabolic steroids. Steroids 131-139 androgen receptor Rattus norvegicus 27-44 9185158-2 1997 Acute swim stress (3 min swim at 32 degrees C) in gonadectomised female mice resulted in a significant increase in GABAA receptor binding in forebrain membranes at GABA concentrations of 400-1000 nM and in the plasma levels of corticosterone, whereas this stress produced no significant change in such binding or steroid levels in gonadectomised male mice. Steroids 313-320 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 115-120 9185158-5 1997 The injection of a combination of oestrogen (1 microgram) and progesterone (0.1 mg) produced a greater reduction in GABAA receptor binding than the injection of either steroid hormone alone. Steroids 168-183 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 116-121 11988089-1 2002 Dehydroepiandrosterone sulphotransferase (DHEA-ST) is an enzyme that converts dehydroepiandrosterone (DHEA), and some other steroids, into their sulphonated forms. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 0-40 11988089-1 2002 Dehydroepiandrosterone sulphotransferase (DHEA-ST) is an enzyme that converts dehydroepiandrosterone (DHEA), and some other steroids, into their sulphonated forms. Steroids 124-132 sulfotransferase family 2A member 1 Homo sapiens 42-49 9166694-12 1997 Staining intensities of P450arom, P450c17, and 3betaHSD were correlated with each other and with follicular fluid concentrations of the steroids estradiol, androstenedione, and progesterone, whose production they catalyzed. Steroids 136-144 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 34-41 9166694-12 1997 Staining intensities of P450arom, P450c17, and 3betaHSD were correlated with each other and with follicular fluid concentrations of the steroids estradiol, androstenedione, and progesterone, whose production they catalyzed. Steroids 136-144 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 47-55 11986781-3 2002 Many kallikrein genes were found to be differentially expressed in various malignancies, and their regulation is controlled by steroid hormones in prostate and breast cancer cell lines. Steroids 127-143 kallikrein related peptidase 4 Homo sapiens 5-15 7418002-1 1980 The X, Y and ovalbumin genes, which are found within a 40 kb region of the chicken genome, are all expressed in oviduct under steroid hormone control, and share some sequence homologies. Steroids 126-141 ovalbumin (SERPINB14) Gallus gallus 13-22 9186292-6 1997 The effects of the steroid on lipolysis disappeared when adenosine was hydrolyzed by adenosine deaminase (ADA). Steroids 19-26 adenosine deaminase Rattus norvegicus 85-104 7387999-0 1980 Ovalbumin messenger ribonucleic acid accumulation in the chick oviduct during secondary stimulation: influence of combinations of steroid hormones and circannual rhythms. Steroids 130-146 ovalbumin (SERPINB14) Gallus gallus 0-9 9211418-4 1997 The actions of oxytocin in the brain are regulated by gonadal steroid hormones, particularly estrogen. Steroids 62-78 oxytocin/neurophysin I prepropeptide Homo sapiens 15-23 9153665-0 1997 Anabolic-androgenic steroid induced alterations in choline acetyltransferase messenger RNA levels of spinal cord motoneurons in the male rat. Steroids 20-27 choline O-acetyltransferase Rattus norvegicus 51-76 9148915-14 1997 Our data suggest that hsp90, hsp70, and p60 work together as a chaperone complex that possesses all of the folding/unfolding activity necessary to generate the high affinity steroid binding conformation of the receptor. Steroids 174-181 heat shock protein family A (Hsp70) member 4 Homo sapiens 29-34 11950789-10 2002 Maximal induction of a PXR-responsive reporter gene of approximately 3-fold was observed at concentrations of 50 to 100 microM, indicating that these steroids are relatively weak activators of PXR. Steroids 150-158 nuclear receptor subfamily 1, group I, member 2 Mus musculus 23-26 11950789-10 2002 Maximal induction of a PXR-responsive reporter gene of approximately 3-fold was observed at concentrations of 50 to 100 microM, indicating that these steroids are relatively weak activators of PXR. Steroids 150-158 nuclear receptor subfamily 1, group I, member 2 Mus musculus 193-196 6988134-6 1980 The recently stated opinion of Taeusch et al seems appropriate: "We conclude that steroids are effective in reducing risk of RDS, but safer and more efficacious approaches for the prevention of RDS should be sought" (91). Steroids 82-90 peripherin 2 Homo sapiens 125-128 11897698-8 2002 These data suggest a role for CSF-1 and its target cells, microglia, in establishing the feedback sensitivity to circulating steroid hormones in the hypothalamus of mice. Steroids 125-141 colony stimulating factor 1 (macrophage) Mus musculus 30-35 10225763-3 1997 Somatostatin belongs to a group of regulatory peptides that antagonize the action of endogenous steroid hormones, and decreasing their bioavailability decreases the rate of synthesis of delta-aminolevulinate synthase, alpha-aminolevunilic acid (ALA), and polypeptides. Steroids 96-112 somatostatin Homo sapiens 0-12 6894051-0 1980 [Effects of intrapartum steroid prophylaxis on complement C3 and total complement activities (author"s transl)]. Steroids 24-31 complement C3 Homo sapiens 47-60 11907515-2 2002 Recently, we elucidated the underlying gene defect by demonstrating point mutations in NSDHL (NAD[P]H steroid dehydrogenase-like protein) at Xq28 in 6 patients with classic CHILD syndrome. Steroids 102-109 NAD(P) dependent steroid dehydrogenase-like Homo sapiens 87-92 479179-0 1979 Transcriptional regulation of the ovalbumin and conalbumin genes by steroid hormones in chick oviduct. Steroids 68-84 ovalbumin (SERPINB14) Gallus gallus 34-43 11972301-2 2002 The authors analysed the predictive role of the vitamin D receptor (VDR) gene for circulating sex steroids and their precursors in postmenopausal women. Steroids 98-106 vitamin D receptor Homo sapiens 48-66 11972301-2 2002 The authors analysed the predictive role of the vitamin D receptor (VDR) gene for circulating sex steroids and their precursors in postmenopausal women. Steroids 98-106 vitamin D receptor Homo sapiens 68-71 9139840-2 1997 At the N-terminal, MLN64 exhibits a potential trans-membrane region, while at the C-terminal, it shares homology with the F26F4.4 protein of Coenorhabditis elegans and the steroidogenic acute regulatory (StAR) protein, a mitochondrial protein which is involved in steroid-hormone synthesis. Steroids 172-179 StAR related lipid transfer domain containing 3 Homo sapiens 19-24 9145499-2 1997 Nitrated gitoxins (4) and bufotoxin homologues with various lengths of alkyl chain at C-3 of the steroid nucleus (10) were prepared from gitoxin (1). Steroids 97-104 complement C3 Rattus norvegicus 86-89 11972301-7 2002 The study shows that the VDR gene predicts synthesis and/or metabolism of sexual steroid preursor DHEA in parallel with bone mineral density (BMD). Steroids 81-88 vitamin D receptor Homo sapiens 25-28 553583-4 1979 A 50 sec exposure to DCC was sufficient to separate bound from free labelled steroid. Steroids 77-84 DCC netrin 1 receptor Homo sapiens 21-24 12025522-0 2002 Effect of steroids on lipopolysaccharide/interleukin 2-induced interleukin 18 production in peripheral blood mononuclear cells. Steroids 10-18 interleukin 18 Homo sapiens 63-77 11889496-5 2002 OBJECTIVES: We questioned the effect of ovarian steroid hormones on MAO-A and MAO-B mRNA expression in the dorsal raphe nucleus and hypothalamus using in situ hybridization in non-human primates. Steroids 48-55 monoamine oxidase B Homo sapiens 78-83 11795941-4 2002 The response to TGF-alpha was polarized in that basolateral, but not apical, exposure to this growth factor coordinately reversed the steroid control of fascin production and tight junction formation. Steroids 134-141 transforming growth factor alpha Rattus norvegicus 16-25 9149392-1 1997 The role of estrogen receptor on ovalbumin mRNA induction by steroid hormones was investigated in primary cultures of oviduct cells from estrogen-stimulated immature chicks of genetically selected high- and low-albumen egg laying lines (H- and L-lines). Steroids 61-77 ovalbumin (SERPINB14) Gallus gallus 33-42 474286-5 1979 In the present study, the smallest fragment of the glucocorticoid receptor containing the steroid-binding site, the mero-receptor, was characterized with respect to the Stokes radius (RS = 23 +/- 3 A) and the isoelectric point (pI = 5.9 at 4 degrees). Steroids 90-97 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 51-74 9237261-0 1997 The progressive rise in the expression of alpha crystallin B chain in human endometrium is initiated during the implantation window: modulation of gene expression by steroid hormones. Steroids 166-182 crystallin alpha B Homo sapiens 42-66 9079669-14 1997 In summary, these results suggest a novel action for the hsp-70 family of proteins as intracellular vitamin D- and gonadal steroid hormone-binding molecules. Steroids 123-138 heat shock protein family A (Hsp70) member 4 Homo sapiens 57-63 11687590-4 2002 Here, we report the generation of transgenic Arabidopsis plants that express the active mutants of AtMEK4 and AtMEK5, two closely related MAPK kinases under the control of a steroid-inducible promoter. Steroids 174-181 MAP kinase kinase 5 Arabidopsis thaliana 110-116 11739103-1 2002 Glutamine synthetase, a key enzyme in the production of glutamine, is known to be induced by glucocorticoids and preserved in skeletal muscle during aging, but the effect of other steroids, such as sex steroids (progesterone, estradiol), is unknown in vivo. Steroids 202-210 glutamate-ammonia ligase Rattus norvegicus 0-20 36690-5 1979 The activity of 3 beta-HSD was inhibited by various steroids. Steroids 52-60 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 16-26 12052919-6 2002 The signaling events underlying the developmental activities of sex steroids involve interactions between nuclear hormone receptors and other transcriptional regulators, as well as interactions at multiple levels with neurotrophin and neurotransmitter signal transduction pathways. Steroids 68-76 brain derived neurotrophic factor Homo sapiens 218-230 9131995-0 1997 NMR studies of the secondary structure in solution and the steroid binding site of delta5-3-ketosteroid isomerase in complexes with diamagnetic and paramagnetic steroids. Steroids 59-66 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 83-113 9131995-0 1997 NMR studies of the secondary structure in solution and the steroid binding site of delta5-3-ketosteroid isomerase in complexes with diamagnetic and paramagnetic steroids. Steroids 161-169 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 83-113 9131995-1 1997 Backbone and side chain resonances of steroid-bound delta5-3-ketosteroid isomerase (EC 5.3.3.1), a homodimeric enzyme with 125 residues per monomer, have been assigned by heteronuclear NMR methods with the 15N- and 13C-labeled enzyme. Steroids 38-45 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 52-82 9067276-8 1997 In support of the involvement of the androgen receptor, steroid specificity of regulation of FAS activity is in agreement with the aberrant ligand specificity of the mutated androgen receptor in LNCaP cells. Steroids 56-63 fatty acid synthase Homo sapiens 93-96 734691-6 1978 The average concentration of steroid in these animals due solely to treatment, calculated from the specific activity of the [14C] progesterone administered, was 3.4 and 18.1 ng/g in muscle and subcutaneous fat, respectively. Steroids 29-36 FAT atypical cadherin 1 Bos taurus 206-209 9056252-2 1997 Progesterone is rapidly hydroxylated by transformed E. coli cells at rates as rapid as 50 nmol of steroid hydroxylated/min/nmol of P450 at 37 degrees C. This rate measured in vivo equals or exceeds the best rates we have measured when reconstituting progesterone hydroxylase activity in vitro using purified recombinant bovine P450c17 and purified recombinant rat NADPH-P450 reductase. Steroids 98-105 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 327-334 12119537-10 2002 The mRNA expressions of VEGF and ICAM-1 detected by a semi-quantitative reverse transcriptase polymerase chain reaction were also induced in response to U. urealyticum and inhibited by the steroids (p < 0.05). Steroids 189-197 intercellular adhesion molecule 1 Homo sapiens 33-39 11879577-8 2002 The increased steroid hormone production in mutant K-ras-transfected cells was reversed by lovastatin, a pharmacologic inhibitor of p21ras function. Steroids 14-29 KRAS proto-oncogene, GTPase Homo sapiens 51-56 685565-3 1978 Occurrence of RDS was significantly lower in cases, where delivery took place more than 48 hours after the steroid treatment. Steroids 107-114 peripherin 2 Homo sapiens 14-17 11891851-2 2002 CAR and PXR have a rather broad, overlapping set of ligands that range from natural steroids to xenobiotics and also recognize similar DNA binding sites, referred to as response elements (REs), primarily in promoter regions of cytochrome P450 (CYP) genes. Steroids 84-92 nuclear receptor subfamily 1 group I member 3 Homo sapiens 0-3 11891851-8 2002 Since an iNOS-induced production of NO is known to influence inflammation and apoptosis, a CAR- and PXR-regulated iNOS activity may explain a modulatory effect of steroids and xenobiotics on these cellular processes. Steroids 163-171 nuclear receptor subfamily 1 group I member 3 Homo sapiens 91-94 9134220-12 1997 In contrast, the steroid was no longer active in reducing cell accumulation in mice which had been passively immunized against full length human recombinant lipocortin 1 (serum LCS3), or against lipocortin 1 N-terminus peptide. Steroids 17-24 annexin A1 Homo sapiens 157-169 841621-3 1977 Both steroids, as well as testosterone, appear to be bound to an 8 - 8.5 S androgen receptor on sucrose density gradient. Steroids 5-13 androgen receptor Rattus norvegicus 75-92 9116135-12 1997 Similar expression patterns of EP3 and EP4 in the Day 4 pseudopregnant mouse uterus or in the ovariectomized uterus under combined treatment with estrogen and progesterone suggest that these genes are regulated by ovarian steroids rather than by the embryo during the preimplantation period (Days 1-4). Steroids 222-230 prostaglandin E receptor 4 (subtype EP4) Mus musculus 39-42 11773614-6 2002 Absorption of NaCl is a rather steady process that is controlled by steroid hormones regulating the expression of epithelial Na(+) channels (ENaC), the Na(+)-K(+)-ATPase, and additional modulating factors such as the serum- and glucocorticoid-regulated kinase SGK. Steroids 68-84 serum/glucocorticoid regulated kinase 1 Homo sapiens 260-263 902880-0 1977 Alcohol dehydrogenase: structural studies, functional aspects and evolutionary conclusions in relation to steroid binding. Steroids 106-113 aldo-keto reductase family 1 member A1 Homo sapiens 0-21 11742225-0 2001 Are POMC neurons targets for sex steroids in the arcuate nucleus of the rat? Steroids 33-41 proopiomelanocortin Rattus norvegicus 4-8 11742225-6 2001 These results suggest that sex steroids have an indirect effect on most POMC neurons. Steroids 31-39 proopiomelanocortin Rattus norvegicus 72-76 11747826-5 2001 In the current study, CARM1 cooperated with GRIP1 to enhance steroid hormone-dependent activation of stably integrated mouse mammary tumor virus (MMTV) promoters, and this coactivator function required the methyltransferase activity of CARM1. Steroids 61-76 coactivator associated arginine methyltransferase 1 Homo sapiens 22-27 11747826-5 2001 In the current study, CARM1 cooperated with GRIP1 to enhance steroid hormone-dependent activation of stably integrated mouse mammary tumor virus (MMTV) promoters, and this coactivator function required the methyltransferase activity of CARM1. Steroids 61-76 coactivator associated arginine methyltransferase 1 Homo sapiens 236-241 11771788-12 2001 The suppression of GHR and IGF-I immunoreactivity in steroid-treated animals infers the mechanism whereby bone resorption and deposition, necessary for orthodontic tooth movement, may be inhibited by prednisolone. Steroids 53-60 growth hormone receptor Rattus norvegicus 19-22 9112288-3 1997 The purpose of the present study was to explore the role of progesterone (P4) as an "anti-inflammatory" steroid for the regulation of PGS-2 and the synthesis of prostaglandins in the PO follicle. Steroids 104-111 decorin Rattus norvegicus 134-139 8990171-1 1997 The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. Steroids 31-38 TATA-box binding protein Homo sapiens 205-225 9059669-0 1997 Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid. Steroids 176-183 fatty acid binding protein 5 Homo sapiens 45-81 9059669-0 1997 Skin-derived antileukoproteinase (SKALP) and epidermal fatty acid-binding protein (E-FABP): two novel markers of the psoriatic phenotype that respond differentially to topical steroid. Steroids 176-183 fatty acid binding protein 5 Homo sapiens 83-89 9059669-3 1997 We used treatment of lesional psoriatic skin with topical steroid as a model to correlate the expression pattern of SKALP and E-FABP with known cell biological events during regression of the psoriatic lesion. Steroids 58-65 fatty acid binding protein 5 Homo sapiens 126-132 9370215-5 1997 Specifically, the mRNA coding for the rate-limiting enzyme in GABA synthesis, glutamic acid decarboxylase (GAD), is up to twice as high in some steroid-concentrating regions of the neonatal male brain compared to females, including the arcuate nucleus, dorsomedial nucleus, and the CA1 region of hippocampus. Steroids 144-151 glutamate decarboxylase 1 Homo sapiens 78-105 9370215-5 1997 Specifically, the mRNA coding for the rate-limiting enzyme in GABA synthesis, glutamic acid decarboxylase (GAD), is up to twice as high in some steroid-concentrating regions of the neonatal male brain compared to females, including the arcuate nucleus, dorsomedial nucleus, and the CA1 region of hippocampus. Steroids 144-151 glutamate decarboxylase 1 Homo sapiens 107-110 63929-2 1977 Depressed PILT responses were observed in oral contraceptive users as compared with age-matched controls, and the magnitude of depression correlated with the duration of oral contraception and was inversely related to the clinical progestagenic potency of the component steroids. Steroids 270-278 tight junction associated protein 1 Homo sapiens 10-14 11717447-0 2001 Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3). Steroids 54-69 cubilin Homo sapiens 0-7 610235-4 1977 In the group where steroid prophylaxis was applied, decrease of RDS morbidity and mortality was observed. Steroids 19-26 peripherin 2 Homo sapiens 64-67 11717447-5 2001 Here, we report that cubilin, a membrane-associated protein colocalizing with megalin, facilitates the endocytic process by sequestering steroid-carrier complexes on the cellular surface before megalin-mediated internalization of the cubilin-bound ligand. Steroids 137-144 cubilin Homo sapiens 21-28 11691951-3 2001 We used a steroid-inducible system to show that the transcription factor-type response regulator ARR1 directs transcriptional activation of the ARR6 gene, which responds to cytokinins without de novo protein synthesis. Steroids 10-17 response regulator 1 Arabidopsis thaliana 97-101 9308233-8 1997 Since dexamethasone causes a loss of myc and synergizes with the anti-IgM signal, we suggest that accelerated cell death with this steroid in the presence of anti-IgM is due to a more rapid degradation of this oncogene product. Steroids 131-138 immunoglobulin heavy constant mu Mus musculus 70-73 9308233-8 1997 Since dexamethasone causes a loss of myc and synergizes with the anti-IgM signal, we suggest that accelerated cell death with this steroid in the presence of anti-IgM is due to a more rapid degradation of this oncogene product. Steroids 131-138 immunoglobulin heavy constant mu Mus musculus 163-166 899345-4 1977 Steroid prophylaxis was applied prenatally with 69 pregnant women at term who were predisposed to give birth to infants developing RDS (retardation, diabetes mellitus, elective section caesareas, etc.). Steroids 0-7 peripherin 2 Homo sapiens 131-134 9094207-3 1997 In cultured imaginal discs, IMP-L3 transcript levels and LDH enzyme activity increase in response to the steroid hormone, 20-hydroxyecdysone. Steroids 105-120 Lactate dehydrogenase Drosophila melanogaster 28-34 9094207-3 1997 In cultured imaginal discs, IMP-L3 transcript levels and LDH enzyme activity increase in response to the steroid hormone, 20-hydroxyecdysone. Steroids 105-120 Lactate dehydrogenase Drosophila melanogaster 57-60 11562357-1 2001 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 1, nephrin Mus musculus 13-18 11562357-1 2001 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 2, podocin Mus musculus 22-27 11562357-1 2001 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 1, nephrin Mus musculus 85-92 8969928-11 1996 These studies suggest that altered MR- and GR-mediated mechanisms may contribute to the resistance of the W/Fu rat strain to steroid-induced hypertension. Steroids 125-132 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 43-45 899345-11 1977 On the basis of their observations the authors consider that steroid therapy applied during labour is efficient in preventing neonatal RDS. Steroids 61-68 peripherin 2 Homo sapiens 135-138 11562357-1 2001 Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. Steroids 112-119 nephrosis 2, podocin Mus musculus 97-104 942255-4 1976 Hydrocortisone and hydrocortisone acetate exerted a significant inhibitory action only in the case of G-6-PDH-activity.--On pure G-6-PDH from yeast, the inhibition exerted by hydrocortisone butyrate was significantly stronger than the inhibition exerted by the two other steroids. Steroids 271-279 glucose-6-phosphate dehydrogenase Homo sapiens 129-136 11744081-4 2001 An additional unexpected mechanism of steroid action is reported here: pregnenolone binds to neural microtubule-associated protein of type 2 (MAP2) and increases both the rate and extent of tubulin polymerization, forming microtubules of normal electron microscopic appearance. Steroids 38-45 microtubule associated protein 2 Homo sapiens 142-146 11578779-5 2001 To determine whether the steroid alterations of A beta uptake in vitro had relevance in vivo, we examined the effects of these steroids on A beta accumulation and mu glial responses to A beta infused into rat brain. Steroids 25-32 amyloid beta precursor protein Rattus norvegicus 48-54 8913873-2 1996 We have previously reported that transcriptional activation of this gene is accompanied by the presence of two DNase I hypersensitive sites, both located in the promoter region spanning key basal (proximal site, -170 to -70) and steroid-dependent enhancer (distal site, -600 to -400) elements. Steroids 229-236 deoxyribonuclease 1 Rattus norvegicus 111-118 9112701-0 1996 Inhibition of prolidase activity by non-steroid antiinflammatory drugs in cultured human skin fibroblasts. Steroids 40-47 peptidase D Homo sapiens 14-23 11578779-16 2001 Our data are also consistent with the hypothesis that although E2 is less potent than Gc in impeding A beta degradation, long term exposure to both steroids could reduce A beta clearance and clinical utility. Steroids 148-156 amyloid beta precursor protein Rattus norvegicus 170-176 9112701-4 1996 Prolidase activity was measured in cultured human skin fibroblasts, treated with some non-steroid antiinflammatory drugs (acetyl-salicylic acid, sodium salicylate, phenylbutazone, indometacin). Steroids 90-97 peptidase D Homo sapiens 0-9 170996-0 1975 The involvement of receptro sulphydryl groups in the binding of steroids to the cytoplasmic glucocorticoid receptor from rat thymus. Steroids 64-72 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 92-115 9112701-7 1996 These observations suggest that non-steroid antiinflammatory drugs affect the metabolism of collagen through inhibition of prolidase activity in the collagen synthesizing cells. Steroids 36-43 peptidase D Homo sapiens 123-132 8890749-1 1996 Adrenodoxin oxidoreductase (ADR) and adrenodoxin (ADX) are the two proteins involved in electron transport to mammalian mitochondrial P-450s capable of steroid modifications. Steroids 152-159 ferredoxin 1 Homo sapiens 50-53 11578779-18 2001 The failure of both steroids to accelerate A beta degradation may explain their lack of efficacy for treatment of AD. Steroids 20-28 amyloid beta precursor protein Rattus norvegicus 43-49 11605071-9 2001 Our results indicate that distinct steroid hormones can specifically influence concentrations of soluble CD44. Steroids 35-42 CD44 molecule (Indian blood group) Homo sapiens 105-109 170996-1 1975 The glucocorticoid receptor protein present in the high-speed supernant fraction of rat thymus tissue is extremely unstable, having a half-life of about 2 h at 4 degrees C. It was found that the decline in steroid-binding capacity could be slowed, though not arrested completely, by the addition of sulphydryl-protecting agents such as 2-mercaptoethanol or dithiothreitol, and by EDTA. Steroids 206-213 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 4-27 173192-0 1975 Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol. Steroids 24-32 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 38-61 1156598-1 1975 The effects of amino acids and adrenocortical steroids on albumin synthesis after partial hepatectomy. Steroids 46-54 albumin Rattus norvegicus 58-65 11754979-1 2001 The actions of calcitonin gene-related peptide (CGRP) and adrenomedullin on steroid hormone secretion from the rat zona glomerulosa are controversial, with reports in the literature of both stimulatory and inhibitory effects. Steroids 76-91 adrenomedullin Rattus norvegicus 58-72 11694291-0 2001 Purification of cytochromes P-450(scc) and P-450(17 alpha) by steroid-binding affinity column chromatography. Steroids 62-69 SCC Bos taurus 28-38 11683717-1 2001 The 3 beta-hydroxysteroid dehydrogenase/Delta 5-Delta 4-isomerase (3 beta-HSD) enzymes are essential for the biosynthesis of steroid hormones. Steroids 125-141 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-77 11853283-1 2001 The most abundant human steroid, dehydroepiandrosterone sulfate (DHEAS), may have a multitude of beneficial effects, but declines with age. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 65-70 11732862-4 2001 IL-12 and IL-15 levels were significantly higher in patients" serum, independently of disease activity, even in patients on steroid therapy, i.e., the present therapies cannot eradicate their origin. Steroids 124-131 interleukin 15 Homo sapiens 10-15 11544284-1 2001 Clara cell secretory protein (CC10) is a steroid-inducible protein, and its in vivo function is currently unclear. Steroids 41-48 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 0-28 11544284-1 2001 Clara cell secretory protein (CC10) is a steroid-inducible protein, and its in vivo function is currently unclear. Steroids 41-48 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 30-34 11591195-8 2001 IL-15 was localized specifically to macrophages and the proportion of these cells expressing IL-15 correlated with sputum fluid IL-15 and IL-15 levels in cell culture supernatants, and all were higher in the steroid-treated asthmatics. Steroids 208-215 interleukin 15 Homo sapiens 0-5 11591195-8 2001 IL-15 was localized specifically to macrophages and the proportion of these cells expressing IL-15 correlated with sputum fluid IL-15 and IL-15 levels in cell culture supernatants, and all were higher in the steroid-treated asthmatics. Steroids 208-215 interleukin 15 Homo sapiens 93-98 11591195-8 2001 IL-15 was localized specifically to macrophages and the proportion of these cells expressing IL-15 correlated with sputum fluid IL-15 and IL-15 levels in cell culture supernatants, and all were higher in the steroid-treated asthmatics. Steroids 208-215 interleukin 15 Homo sapiens 93-98 11591195-8 2001 IL-15 was localized specifically to macrophages and the proportion of these cells expressing IL-15 correlated with sputum fluid IL-15 and IL-15 levels in cell culture supernatants, and all were higher in the steroid-treated asthmatics. Steroids 208-215 interleukin 15 Homo sapiens 93-98 11591195-9 2001 CONCLUSION: IL-15 and IL-13 production appears to be reciprocally regulated by steroid therapy in asthma patients. Steroids 79-86 interleukin 15 Homo sapiens 12-17 11591195-10 2001 The steroid-associated increase in IL-15 may regulate a fundamental shift away from an inflammatory Th2-type environment in asthma and may be an essential component of the cytokine modulation underlying the therapeutic benefit of corticosteroids in this condition. Steroids 4-11 interleukin 15 Homo sapiens 35-40 11589343-3 2001 The expression of GATA-3, 4 and -6 was investigated in peripheral blood T-lymphocytes and monocytes and bronchial biopsies from 11 normal subjects and 10 steroid-naive asthmatic patients. Steroids 154-161 GATA binding protein 3 Homo sapiens 18-34 11520138-9 2001 In contrast, expression of stromal MMP-9 was suppressed in the presence of ovarian steroids. Steroids 83-91 matrix metallopeptidase 9 Homo sapiens 35-40 11459771-4 2001 The steroidogenic acute regulatory protein regulates cholesterol delivery to the P450(scc) enzyme, a process that is rate limiting in steroid hormone biosynthesis. Steroids 134-149 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 86-89 11476767-9 2001 RESULT(S): The levels of all of the steroids that derived from DHEA metabolism (E1, E2, A, T, DHEAS) and osteocalcin were increased in plasma under DHEA supplementation. Steroids 36-44 sulfotransferase family 2A member 1 Homo sapiens 94-99 11505280-8 2001 The results indicate that nNOS mRNA expression in the rPOA is regulated by ovarian steroids in a site-specific manner. Steroids 83-91 nitric oxide synthase 1 Rattus norvegicus 26-30 11470861-8 2001 These results suggest that the production of GROalpha by ESC is regulated by ovarian steroid hormones as well as by inflammatory mediators. Steroids 85-101 C-X-C motif chemokine ligand 1 Homo sapiens 45-53 14715464-11 2001 The presence of CYP3A predominantly in neurons but also in cells contributing to the blood-brain and blood-liquor barrier suggests important roles of this subfamily in mediation of steroid hormone action in mouse brain as well as in preventing the brain from potentially cytotoxic compounds. Steroids 181-196 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 16-21 11403976-0 2001 Effects of gonadal steroids on peripheral benzodiazepine receptor density in women with PMS and controls. Steroids 19-27 translocator protein Homo sapiens 31-65 11403976-2 2001 The peripheral benzodiazepine receptor (PBR) both regulates the formation of neurosteroids and is, in animals, regulated by ovarian steroids. Steroids 82-90 translocator protein Homo sapiens 4-38 11403976-2 2001 The peripheral benzodiazepine receptor (PBR) both regulates the formation of neurosteroids and is, in animals, regulated by ovarian steroids. Steroids 82-90 translocator protein Homo sapiens 40-43 11403976-4 2001 METHODS: We examined the effects of gonadal steroids on lymphocytic PBR density in nine women with prospectively confirmed PMS and nine controls. Steroids 44-52 translocator protein Homo sapiens 68-71 11478605-0 2001 Immunoreactivity of A103, an antibody to Melan A, in canine steroid-producing tissues and their tumors. Steroids 60-67 melan-A Canis lupus familiaris 41-48 11478605-1 2001 The monoclonal antibody A103 to the melanocytic differentiation antigen Melan A stains human steroid-producing cells and their tumors. Steroids 93-100 melan-A Homo sapiens 72-79 11478605-7 2001 As in human tumors, immunohistochemistry for Melan A stains many canine steroid-producing tumors and can be used to distinguish these tumors from those of nonstereidogenic cells. Steroids 72-79 melan-A Homo sapiens 45-52 11381125-8 2001 GR-LACS may contribute to the provision of energy requirements and to the biosynthesis of steroid precursors and could participate through acyl-CoA"s multiple functions in the regulation of the male gonad. Steroids 90-97 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 0-7 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). Steroids 136-144 negative elongation factor complex member C/D Homo sapiens 155-158 11407316-6 2001 In a comparative study with steroids (alclometasone dipropionate and betamethason valerate) in anti-CD3/CD2 system, tacrolimus and both steroids inhibited Th1 cytokines (IL-2, IFN-gamma), Th2 cytokines (IL-4, IL-5) and IL-3, GM-CSF (produced by both Th1 and Th2). Steroids 136-144 negative elongation factor complex member C/D Homo sapiens 250-253 11294780-11 2001 We also used RT-PCR to determine whether there was an increase in nNOS mRNA after treatment with sex steroids. Steroids 101-109 nitric oxide synthase 1 Rattus norvegicus 66-70 11334911-13 2001 HGF and SCF modulate the interplay between theca and granulosa cells by promoting cell proliferation and steroid hormone production. Steroids 105-120 KIT ligand Homo sapiens 8-11 11290410-4 2001 In this study, we examined whether IGF-1 affected steroid-induced enhancement of GS activity in L6 rat skeletal muscle cells. Steroids 50-57 glutamate-ammonia ligase Rattus norvegicus 81-83 11290410-8 2001 These results suggest that a decrease in GS activity may be involved in the preventive effect of IGF-1 on steroid myopathy. Steroids 106-113 glutamate-ammonia ligase Rattus norvegicus 41-43 11309290-6 2001 In ABCA2-transfected cells, the transporter also colocalized with a fluorescently labeled steroid analogue, estramustine. Steroids 90-97 ATP binding cassette subfamily A member 2 Homo sapiens 3-8 11309290-7 2001 The sequestration of the steroid into the lysosomal/endosomal compartment indicates a potential substrate specificity for ABCA2. Steroids 25-32 ATP binding cassette subfamily A member 2 Homo sapiens 122-127 11309290-8 2001 Furthermore, the presence of a lipocalin signature motif in the ABCA2 sequence suggests a possible broad role for this protein in the transport of steroids, lipids, and related molecules. Steroids 147-155 ATP binding cassette subfamily A member 2 Homo sapiens 64-69 11259452-8 2001 These data, taken together, indicate that the expression of BRE is apparently associated with steroids and/or TNF production and the regulation of endocrine functions. Steroids 94-102 BRISC and BRCA1 A complex member 2 Homo sapiens 60-63 11345690-4 2001 The inhibitory activity of Rb1 and Rb2 was significantly increased by pharmacological agents against protein kinase C, protein tyrosine kinase, and protein kinase A, and anti-rheumatoid arthritis drugs, such as chloroquine and steroid drugs. Steroids 227-234 RB transcriptional corepressor like 2 Homo sapiens 35-38 11231856-7 2001 Furthermore, serum and peritoneal IL-10 levels were significantly higher in the steroid group. Steroids 80-87 interleukin 10 Homo sapiens 34-39 11231856-11 2001 CONCLUSIONS: Preoperative steroid administration significantly elevated anti-inflammatory cytokine IL-10 levels, suppressed the levels of inflammatory cytokines IL-6 and C-reactive protein, and prevented postoperative elevation of total bilirubin values. Steroids 26-33 interleukin 10 Homo sapiens 99-104 11266076-7 2001 The highest expression level of CYP3A43 mRNA is observed in the prostate, an organ with extensive steroid metabolism. Steroids 98-105 cytochrome P450 family 3 subfamily A member 43 Homo sapiens 32-39 11181814-10 2001 In contrast, both steroids induced significant decreases of GAD(65) and GAD(67) mRNA levels in male hypothalamus, but had no effect on GAD mRNA expression in male telencephalon. Steroids 18-26 glutamate decarboxylase 1 Homo sapiens 72-79 11154266-4 2001 In this report, we describe the steroid-induced homomeric interaction of the rat glucocorticoid receptor (GR) in solution in vivo. Steroids 32-39 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 81-104 11154266-4 2001 In this report, we describe the steroid-induced homomeric interaction of the rat glucocorticoid receptor (GR) in solution in vivo. Steroids 32-39 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 106-108 11306084-2 2001 To elucidate the molecular determinants of steroid hormone recognition we used rat liver 3alpha-HSD (AKR1C9) as a starting structure to engineer either 5beta-reductase or 20alpha-HSD activity. Steroids 43-58 aldo-keto reductase family 1, member C14 Rattus norvegicus 89-99 11306084-2 2001 To elucidate the molecular determinants of steroid hormone recognition we used rat liver 3alpha-HSD (AKR1C9) as a starting structure to engineer either 5beta-reductase or 20alpha-HSD activity. Steroids 43-58 aldo-keto reductase family 1, member C14 Rattus norvegicus 101-107 11306084-7 2001 Since 5beta-reductase precedes 3alpha-HSD in steroid hormone metabolism it is likely that this metabolic pathway arose by gene duplication and point mutation. Steroids 45-60 aldo-keto reductase family 1 member C4 Homo sapiens 31-41 11149946-2 2001 The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that bind certain steroids, neuroleptics, and psychotropic drugs, form a trimeric complex with ankyrin B and IP(3)R type 3 (IP(3)R-3) in NG-108 cells. Steroids 113-121 sigma non-opioid intracellular receptor 1 Homo sapiens 29-46 11149946-2 2001 The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that bind certain steroids, neuroleptics, and psychotropic drugs, form a trimeric complex with ankyrin B and IP(3)R type 3 (IP(3)R-3) in NG-108 cells. Steroids 113-121 sigma non-opioid intracellular receptor 1 Homo sapiens 48-54 11024013-2 2001 In this study, we demonstrated the regulated expression of syndecan-3 in the rat uterus by the steroid hormone 17 beta-estradiol. Steroids 95-110 syndecan 3 Rattus norvegicus 59-69 11133691-5 2001 We hypothesized that the female sex steroid hormones upregulate NGF receptors, trkA and p75(NTR), in DRG. Steroids 36-52 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 79-83 11589621-5 2001 Our data suggest that phenol red and steroid hormones present in culture medium and FBS supplement, respectively, may somehow upregulate CFTR expression in vitro. Steroids 37-44 cystic fibrosis transmembrane conductance regulator Mus musculus 137-141 11182568-2 2001 The nonradioactive steroid binds with high affinity and specificity to the androgen receptor and binds poorly, if at all, to other steroid receptors and plasma sex hormone binding globulin. Steroids 19-26 androgen receptor Rattus norvegicus 75-92 11134123-1 2000 Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids. Steroids 81-88 sulfotransferase family 2A member 1 Homo sapiens 48-53 11115773-5 2000 Conversion of DHEAS to DHEA was assessed in luteinized granulosa cells by tritiated steroid assay following incubation with or without LH or insulin and steroid accumulation in the medium measured by RIA. Steroids 84-91 sulfotransferase family 2A member 1 Homo sapiens 14-19 11115773-5 2000 Conversion of DHEAS to DHEA was assessed in luteinized granulosa cells by tritiated steroid assay following incubation with or without LH or insulin and steroid accumulation in the medium measured by RIA. Steroids 153-160 sulfotransferase family 2A member 1 Homo sapiens 14-19 11080236-0 2000 Steroid responsive polyneuropathy in a family with a novel myelin protein zero mutation. Steroids 0-7 myelin protein zero Homo sapiens 59-78 11080236-1 2000 OBJECTIVE: To report a novel hereditary motor and sensory neuropathy (HMSN) phenotype, with partial steroid responsiveness, caused by a novel dominant mutation in the myelin protein zero (MPZ) gene. Steroids 100-107 myelin protein zero Homo sapiens 167-186 11080236-1 2000 OBJECTIVE: To report a novel hereditary motor and sensory neuropathy (HMSN) phenotype, with partial steroid responsiveness, caused by a novel dominant mutation in the myelin protein zero (MPZ) gene. Steroids 100-107 myelin protein zero Homo sapiens 188-191 10973946-2 2000 The most important reaction for this class of steroids is the reversible C11 keto/beta-hydroxyl conversion between receptor-binding 11beta-OH steroids and the nonbinding 11-oxo compounds, carried out by 11beta-hydroxysteroid dehydrogenases (11beta-HSDs). Steroids 46-54 aldo-keto reductase family 1 member C4 Homo sapiens 73-76 11069441-11 2000 DD4 also has hydroxysteroid dehydrogenase activity which could account for the potent inhibition by the steroid hormones testosterone and dihydrotestosterone. Steroids 104-120 aldo-keto reductase family 1 member C4 Homo sapiens 0-3 11056051-8 2000 Our preliminary results indicate that the expression of KLK12 is down-regulated at the mRNA level in breast cancer tissues and is up-regulated by steroid hormones in breast and prostate cancer cell lines. Steroids 146-162 kallikrein related peptidase 12 Homo sapiens 56-61 10996858-1 2000 We have previously shown that the steroid hormone 1, 25-dihydroxy-vitamin D(3) [1,25(OH)(2)D(3)] stimulates total cell protein kinase C (PKC) activity in rat duodenum, an effect that is severely impaired in old animals. Steroids 34-41 protein kinase C, alpha Rattus norvegicus 137-140 10942888-0 2000 Effects of gonadal steroids during pubertal development on androgen and estrogen receptor-alpha immunoreactivity in the hypothalamus and amygdala. Steroids 19-27 estrogen receptor Mesocricetus auratus 72-95 10996431-4 2000 The sgk mRNA levels were significantly elevated by both steroids by 30 min in the distal colon, reaching a peak at 2 h. A more modest increase in sgk mRNA levels was also seen in the kidney in response to both steroids. Steroids 56-64 serum/glucocorticoid regulated kinase 1 Homo sapiens 4-7 10996431-4 2000 The sgk mRNA levels were significantly elevated by both steroids by 30 min in the distal colon, reaching a peak at 2 h. A more modest increase in sgk mRNA levels was also seen in the kidney in response to both steroids. Steroids 210-218 serum/glucocorticoid regulated kinase 1 Homo sapiens 4-7 10996431-4 2000 The sgk mRNA levels were significantly elevated by both steroids by 30 min in the distal colon, reaching a peak at 2 h. A more modest increase in sgk mRNA levels was also seen in the kidney in response to both steroids. Steroids 210-218 serum/glucocorticoid regulated kinase 1 Homo sapiens 146-149 10932075-0 2000 Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-gamma, IL-1beta, TNF-alpha, or neutrophils. Steroids 8-15 ribonuclease A family member 3 Homo sapiens 97-124 8897914-3 1996 However, the ability of CCSP to bind small lipophilic molecules, such as steroid hormones and certain pollutants, has led to speculation that this protein may mediate the biological accumulation of potentially harmful polychlorinated biphenyl (PCB) metabolites within the lung. Steroids 73-80 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 24-28 8984917-0 1996 Effects of inhaled steroid treatment on serum eosinophilic cationic protein (ECP) and low affinity receptor for IgE (Fc epsilon RII/sCD23) in childhood bronchial asthma. Steroids 19-26 ribonuclease A family member 3 Homo sapiens 46-75 8984917-0 1996 Effects of inhaled steroid treatment on serum eosinophilic cationic protein (ECP) and low affinity receptor for IgE (Fc epsilon RII/sCD23) in childhood bronchial asthma. Steroids 19-26 ribonuclease A family member 3 Homo sapiens 77-80 8947831-5 1996 These results suggested that the prolongation of the half-life of OVA mRNA by steroid hormones is constant irrespective of differential transcription rates of the OVA gene. Steroids 78-94 ovalbumin (SERPINB14) Gallus gallus 66-69 8953906-11 1996 The concentration of eosinophil cationic protein in serum and the results of the methacholine inhalation test reflected the degree of chronic eosinophilic pneumonia, and the production of eosinophils in bone marrow was suppressed by steroid medication. Steroids 233-240 ribonuclease A family member 3 Homo sapiens 21-48 8890156-2 1996 Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone. Steroids 158-173 fork head Drosophila melanogaster 11-20 8890156-2 1996 Two of the Fork head/SEBP2 binding sites are located within an ecdysone response unit which controls the tissue- and stage-specific responses of Sgs-4 to the steroid hormone 20-hydroxyecdysone. Steroids 158-173 fork head Drosophila melanogaster 21-26 8882158-1 1996 Exogenous sex steroids have altered growth hormone secretion in some domestic species. Steroids 14-22 somatotropin Ovis aries 36-50 8943800-2 1996 A signalling pathway, have yielded inconsistent findings on the expression of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD and 17 alpha-hydroxylase cytochrome P450 (P450c17) as well as the corresponding responses on steroid secretory products in human adrenocortical cells. Steroids 92-99 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 115-125 8883217-6 1996 Using the three-dimensional structure of rat liver 3 alpha-HSD as a template for site-directed mutagenesis, details regarding structure function relationships, including catalysis and cofactor and steroid hormone recognition have been elucidated. Steroids 197-212 aldo-keto reductase family 1, member C14 Rattus norvegicus 51-62 8768691-8 1996 Steroids such as dexamethasone, corticosterone, hydrocortisone and, to a lesser extent, dehydroepiandosterone inhibited the stimulated release of CRF-BP from astrocytes. Steroids 0-8 corticotropin releasing hormone binding protein Rattus norvegicus 146-152 8843413-7 1996 To investigate this further, we examined the steroid-regulated expression of an endogenous thymocyte-specific gene called GIG18. Steroids 45-52 glucocorticoid induced transcript 1 Mus musculus 122-127 8843413-8 1996 We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells. Steroids 247-254 glucocorticoid induced transcript 1 Mus musculus 14-19 8843413-8 1996 We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells. Steroids 247-254 androgen receptor Mus musculus 99-101 8843413-8 1996 We found that GIG18 was rapidly induced to comparable levels by both AR and GR, demonstrating that AR can indeed function as a transcriptional activator in S49 cells and, moreover, that GIG18 induction may be a marker of early apoptotic events in steroid-treated cells. Steroids 247-254 glucocorticoid induced transcript 1 Mus musculus 186-191 8675566-2 1996 To evaluate the potential for modulation of IGF action in the primate myometrium by locally produced IGF binding proteins (IGFBPs), we examined the cellular localization and sex steroid regulation of IGFBPs 1-5 in the nonhuman primate uterus. Steroids 178-185 insulin like growth factor binding protein 1 Macaca mulatta 200-206 8675566-5 1996 IGFBP-2, -3, -4, and -5 mRNAs were all expressed by myometrial smooth muscle cells but each displayed distinctive patterns of regulation by sex steroids. Steroids 144-152 insulin like growth factor binding protein 2 Macaca mulatta 0-23 8675566-11 1996 In summary, this study has shown that four of the six known IGFBPs are highly expressed in the primate myometrium, and that their expression is differentially regulated by sex steroids. Steroids 176-184 insulin like growth factor binding protein 1 Macaca mulatta 60-66 8675566-12 1996 The cellular and sex steroid-regulated pattern of IGFBP-2 gene expression is very similar to that of IGF-I, as previously determined in these same myometrial samples. Steroids 21-28 insulin like growth factor binding protein 2 Macaca mulatta 50-57 9139449-4 1996 The latter are translocated into cell nucleus activate the function of genetic apparatus, change biosynthesis of specific enzymes realizing intracellular glucocorticoid effect Receptor mechanism of antiglucocorticoid effect is realized via competition of steroid and non-steroid drugs with glucocorticoids for binding sites on GR or pharmacological stabilization of GR-HSP complex, decreasing 4SGR release, 4S GR-G forming, and 4SGR-G translocation into cell nucleus. Steroids 255-262 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 369-372 9139449-4 1996 The latter are translocated into cell nucleus activate the function of genetic apparatus, change biosynthesis of specific enzymes realizing intracellular glucocorticoid effect Receptor mechanism of antiglucocorticoid effect is realized via competition of steroid and non-steroid drugs with glucocorticoids for binding sites on GR or pharmacological stabilization of GR-HSP complex, decreasing 4SGR release, 4S GR-G forming, and 4SGR-G translocation into cell nucleus. Steroids 271-278 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 369-372 8818409-2 1996 We report there the effects of two steroids (alfaxalone and pregnenolone sulfate) on the inhibition induced by two GABAA agonists, 3-amino propane sulphonic acid (3-APS) and muscimol, on the extracellular evoked potentials obtained in CA1 of mice hippocampi. Steroids 35-43 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 115-120 8818409-5 1996 Our results confirm the possibility that there might be differences in the interaction between GABAA agonists and modulatory steroids. Steroids 125-133 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 95-100 8782080-0 1996 The ARP-1 orphan receptor represses steroid-mediated stimulation of human placental lactogen gene expression. Steroids 36-43 actin related protein 1A Homo sapiens 4-9 8782080-4 1996 Mobility shift assays demonstrated that ARP-1 binds specifically to a composite steroid response element on the hPL promoter that confers retinoic acid and T3 responsiveness. Steroids 80-87 actin related protein 1A Homo sapiens 40-45 8662785-3 1996 Using both direct assay of heterocomplex assembly by Western blotting and indirect assay of assembly by steroid binding, it has previously been determined that the assembly system is both ATP/Mg2+-dependent and K+-dependent and that hsp70 and an acidic 23-kDa protein (p23) are required to form a functional GR.hsp90 complex. Steroids 104-111 heat shock protein family A (Hsp70) member 4 Homo sapiens 233-238 8699423-2 1996 The binding of alpha 1-acid glycoprotein glycoforms to their receptors is inhibited by steroids. Steroids 87-95 orosomucoid 1 Rattus norvegicus 15-40 8699423-8 1996 The interaction between alpha 1-acid glycoprotein glycoforms and their receptors may modulate the actions of testosterone and other steroids in the testis. Steroids 132-140 orosomucoid 1 Rattus norvegicus 24-49 8628267-1 1996 Because induction of the chicken ovalbumin (Ov) gene by steroid hormones requires concomitant protein synthesis, efforts have focused on defining the binding site in the Ov gene for a labile transcription factor. Steroids 56-72 ovalbumin (SERPINB14) Gallus gallus 33-42 8628267-1 1996 Because induction of the chicken ovalbumin (Ov) gene by steroid hormones requires concomitant protein synthesis, efforts have focused on defining the binding site in the Ov gene for a labile transcription factor. Steroids 56-72 ovalbumin (SERPINB14) Gallus gallus 44-46 8628267-11 1996 These data support the contention that the ovalbumin gene is regulated by a steroid hormone-induced transcriptional cascade that culminates in the binding of chicken ovalbumin induced regulatory protein or protein complex (Chirp-I) to a DNA element from -891 to -878 in the SDRE. Steroids 76-91 ovalbumin (SERPINB14) Gallus gallus 43-52 8628267-11 1996 These data support the contention that the ovalbumin gene is regulated by a steroid hormone-induced transcriptional cascade that culminates in the binding of chicken ovalbumin induced regulatory protein or protein complex (Chirp-I) to a DNA element from -891 to -878 in the SDRE. Steroids 76-91 ovalbumin (SERPINB14) Gallus gallus 166-175 8626619-5 1996 Transient transfection of different cell lines with a steroid-responsive reporter plasmid and receptor expression plasmids revealed that transcriptional activity mediated by GR in response to agonists was strongly suppressed by coexpression of ERR2. Steroids 54-61 estrogen related receptor beta Homo sapiens 244-248 8733012-6 1996 The congenital deficiency is associated with mutations in the gene encoding the kidney isoform of 11 beta-HSD2; the acquired form results from inhibition of the enzyme by licorice, carbenoxolone, ACTH-dependent steroids in the ectopic ACTH syndrome, and possibly circulating inhibitors of the enzyme. Steroids 211-219 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 98-110 8572786-13 1996 CONCLUSIONS: Earlier steroid administration in the immunosuppressive protocol for HTx or HLTx may be preferable to reduce the inflammatory response to cardiopulmonary bypass, as reflected by a lower production of tumor necrosis factor alpha and IL-8, and a greater release of IL-10. Steroids 21-28 interleukin 10 Homo sapiens 276-281 8593831-2 1996 We hypothesized that an intracellular vitamin D binding protein (IDBP), present in both nuclear and cytoplasmic fractions of NWP cells, or another protein(s) may cause or contribute to the steroid hormone-resistant state in NWP by disruption of the receptor dimerization process and/or by interference of receptor complex binding to the consensus response elements present in the enhancer regions of steroid-responsive genes. Steroids 189-204 GC vitamin D binding protein Homo sapiens 38-63 8593831-2 1996 We hypothesized that an intracellular vitamin D binding protein (IDBP), present in both nuclear and cytoplasmic fractions of NWP cells, or another protein(s) may cause or contribute to the steroid hormone-resistant state in NWP by disruption of the receptor dimerization process and/or by interference of receptor complex binding to the consensus response elements present in the enhancer regions of steroid-responsive genes. Steroids 189-196 GC vitamin D binding protein Homo sapiens 38-63 8833380-4 1996 The results suggest that the cytosolic progesterone receptor binding in the hen uterus may be modulated by the sex steroid hormones. Steroids 115-131 progesterone receptor Gallus gallus 39-60 8750437-2 1996 Steroids hydroxylated at C-15 have long provided useful information about the well-being of the fetus and feto-placental unit in human pregnancy. Steroids 0-8 placenta associated 8 Homo sapiens 25-29 8975639-1 1996 The effects of cadmium (Cd) administration to intact rats on hepatic glucocorticoid receptor (GR) steroid binding capacity and DNA-binding ability were examined and correlated with the influence of the metal on rat liver tyrosine aminotransferase (TAT) activity and its induction by dexamethasone. Steroids 98-105 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 94-96 8975639-3 1996 administration of Cd doses ranging from 0.5 to 4 mg/kg, the GR steroid- and DNA-binding activities were significantly reduced in a dose-dependent manner. Steroids 63-70 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 60-62 8840085-6 1996 Steroid/neurotrophin interactions may stimulate the synthesis of proteins required for neuronal differentiation, survival and maintenance of function. Steroids 0-7 brain derived neurotrophic factor Homo sapiens 8-20 11211233-3 2000 In fact, at short times of exposure (2 h) a slight decrease in FGF-1 mRNA levels is induced by deoxycorticosterone, a steroid able to interact with the type I receptors; a similar effect is observed at 6 h following exposure to corticosterone or its 5alpha-reduced metabolite, dihydrocorticosterone. Steroids 118-125 fibroblast growth factor 1 Rattus norvegicus 63-68 10955927-9 2000 We conclude that prior to treatment the distribution of lymphocyte subpopulations in peripheral blood together with Th1 and Th2 cell activity provides a useful tool for evaluating the likelihood of steroid sensitivity in patients with primary NS. Steroids 198-205 negative elongation factor complex member C/D Homo sapiens 116-119 8964579-16 1996 GH, insulin and sex steroids also influence plasma GHBP levels. Steroids 20-28 growth hormone receptor Homo sapiens 51-55 170765-1 1975 Alcohol dehydrogenase from horse (isoenzyme SS and ES, but not EE), rat and human liver were found to catalyze the NAD-dependent oxidation of 3beta-hydroxy groups in 5alpha- and 5beta-steroids of the C19, C21, and C24 series. Steroids 184-192 aldo-keto reductase family 1 member A1 Homo sapiens 0-21 8530364-5 1995 Sequence analysis of rat and mouse hct-1 cDNAs revealed extensive homologies with cytochrome P450s (CYPs), a diverse family of heme-binding monooxygenases that metabolize a range of substrates including steroids, fatty acids, and xenobiotics. Steroids 203-211 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 35-40 4248056-1 1970 V. The in vitro biosynthesis of steroids by the male-phase ovotestis of the slug (Ariolimax californicus). Steroids 32-40 snail family transcriptional repressor 2 Homo sapiens 76-80 8530364-6 1995 Among the CYPs, hct-1 is most similar (39% at the amino acid sequence) to cholesterol 7 alpha-hydroxylase (CYP7) and contains a postulated steroidogenic domain present in other steroid-metabolizing CYPs but clearly represents a type of CYP not previously reported. Steroids 139-146 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 16-21 8530364-9 1995 Similarity to CYP7 and other steroid-metabolizing CYPs may argue that hct-1 (CYP7B) plays a role in steroid metabolism in brain, notable because of the documented ability of brain-derived steroids (neurosteroids) to modulate cognitive function in vivo. Steroids 29-36 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 70-75 8530364-9 1995 Similarity to CYP7 and other steroid-metabolizing CYPs may argue that hct-1 (CYP7B) plays a role in steroid metabolism in brain, notable because of the documented ability of brain-derived steroids (neurosteroids) to modulate cognitive function in vivo. Steroids 100-107 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 70-75 8530364-9 1995 Similarity to CYP7 and other steroid-metabolizing CYPs may argue that hct-1 (CYP7B) plays a role in steroid metabolism in brain, notable because of the documented ability of brain-derived steroids (neurosteroids) to modulate cognitive function in vivo. Steroids 188-196 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 70-75 10923206-3 2000 An additional unforeseen mechanism of steroid action is reported here: PREG binds to neural microtubule-associated protein MAP2 and increases both the rate and extent of tubulin polymerization studied in vitro with purified tubulin and MAP2, forming microtubules of normal electron microscopic appearance. Steroids 38-45 microtubule associated protein 2 Homo sapiens 123-127 10923206-3 2000 An additional unforeseen mechanism of steroid action is reported here: PREG binds to neural microtubule-associated protein MAP2 and increases both the rate and extent of tubulin polymerization studied in vitro with purified tubulin and MAP2, forming microtubules of normal electron microscopic appearance. Steroids 38-45 microtubule associated protein 2 Homo sapiens 236-240 4393184-0 1970 On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase. Steroids 22-29 glucose-6-phosphate dehydrogenase Homo sapiens 55-88 10865086-2 2000 Both IL-4 and IL-10 expression vary significantly with relapse/remission in MS and IL-9 is postulated to inhibit steroid-induced apoptosis. Steroids 113-120 interleukin 10 Homo sapiens 14-19 10832999-7 2000 While there were no significant differences in the magnitude of tooth movement between the 2 groups, steroid-treated rats displayed significantly less root resorption on the compression side and fewer TRAP-positive cells within the PDL space on the same side. Steroids 101-108 acid phosphatase 5, tartrate resistant Rattus norvegicus 201-205 7492328-10 1995 These results suggest that binding of acyl-CoA and acylation of UDPGT isoforms regulate the enzyme activities, implying a possible novel function for fatty acyl-CoA in glucuronidation, which is involved in the metabolism of drugs, steroids and bilirubin. Steroids 231-239 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 64-69 8525490-12 1995 The negative effect of lead on testosterone and progesterone production was correlated with the lower expression of the enzymes cytochromes P450scc (CYP11A1) and P450c17 (CYP17) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) involved in steroid hormone biosynthesis, as shown by immunohistochemistry. Steroids 243-258 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 140-147 8525490-12 1995 The negative effect of lead on testosterone and progesterone production was correlated with the lower expression of the enzymes cytochromes P450scc (CYP11A1) and P450c17 (CYP17) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) involved in steroid hormone biosynthesis, as shown by immunohistochemistry. Steroids 243-258 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 149-156 5783476-4 1969 A mechanism for the removal of the 14alpha-methyl group in steroid biosynthesis that involves the labilization of a C-15 hydrogen atom is outlined. Steroids 59-66 placenta associated 8 Homo sapiens 116-120 8554357-6 1995 In a longitudinal trial, antiasthmatic treatment modalities (that is steroids) reduced serum ECP within four weeks (42.2 micrograms/l v 19.0 micrograms/l). Steroids 69-77 ribonuclease A family member 3 Homo sapiens 93-96 10809383-6 2000 Although this protein expresses numerous calcium binding sites on its external domain, its main function may be calcium sensitive binding and uptake of steroid hormones, such as 25-OH-vitamin D3 (bound to vitamin D binding protein) and retinol. Steroids 152-168 GC vitamin D binding protein Homo sapiens 205-230 10750024-5 2000 These results suggest that inhibition of PP1 and PP2A inhibits steroid production by preventing the expression of the StAR protein, implicating PP1/2A dephosphorylation reactions as important regulators of stimulus-dependent StAR protein expression, and thus of steroidogenesis. Steroids 63-70 protein phosphatase 2, regulatory subunit A, alpha Mus musculus 49-53 5950601-8 1966 Steroids may act in part by preventing interaction between the activated kallikrein and its substrate. Steroids 0-8 kallikrein related peptidase 4 Homo sapiens 73-83 10702249-2 2000 Hop binds independently to Hsp90 and to Hsp70 to form a Hsp90.Hop.Hsp70.Hsp40 complex that is sufficient to convert the GR to its steroid binding form, and this four-protein complex will form stable GR.Hsp90 heterocomplexes if p23 is added to the system (Dittmar, K. D., Banach, M., Galigniana, M. D., and Pratt, W. B. Steroids 130-137 heat shock protein family A (Hsp70) member 4 Homo sapiens 40-45 10702249-2 2000 Hop binds independently to Hsp90 and to Hsp70 to form a Hsp90.Hop.Hsp70.Hsp40 complex that is sufficient to convert the GR to its steroid binding form, and this four-protein complex will form stable GR.Hsp90 heterocomplexes if p23 is added to the system (Dittmar, K. D., Banach, M., Galigniana, M. D., and Pratt, W. B. Steroids 130-137 heat shock protein family A (Hsp70) member 4 Homo sapiens 66-71 10702249-10 2000 By carrying out assembly in the presence of radiolabeled steroid to bind to the GR as soon as it is converted to the steroid binding state, we show that the folding change is brought about by only two essential components, Hsp90 and Hsp70, and that Hop, Hsp40, and p23 act as nonessential co-chaperones. Steroids 57-64 heat shock protein family A (Hsp70) member 4 Homo sapiens 233-238 10702249-10 2000 By carrying out assembly in the presence of radiolabeled steroid to bind to the GR as soon as it is converted to the steroid binding state, we show that the folding change is brought about by only two essential components, Hsp90 and Hsp70, and that Hop, Hsp40, and p23 act as nonessential co-chaperones. Steroids 117-124 heat shock protein family A (Hsp70) member 4 Homo sapiens 233-238 8580275-3 1995 Corticosteroids mediate some of their actions through lipocortin-1, and the induction of autoantibodies to lipocortin has been proposed as a possible mechanism by which steroid efficacy is suboptimal in vivo. Steroids 7-14 annexin A1 Homo sapiens 54-66 8541027-8 1995 There may be an abnormal activation of AP-1 in steroid-resistant asthma, and high concentrations of beta 2-agonists may induce a secondary resistance by an interaction between the transcription factor CREB and the glucocorticoid receptor. Steroids 47-54 cAMP responsive element binding protein 1 Homo sapiens 201-205 13904613-0 1962 The uptake and subcellular distribution of C-14-labeled steroid in rat ventral prostate following in vivo administration of testosterone-4-C-14. Steroids 56-63 anti-Mullerian hormone receptor type 2 Rattus norvegicus 43-47 7575668-2 1995 Separate cell protein fractions were prepared to study the influence of the glucocorticoid steroid, dexamethasone, on LC-1 localisation. Steroids 91-98 annexin A1 Homo sapiens 118-122 7578686-3 1995 CRH had a stimulatory effect on steroid production in both isolated preparations of mouse Leydig cells (80-90% Leydig cells) and MA-10 cells (a mouse Leydig tumor cell line). Steroids 32-39 corticotropin releasing hormone Mus musculus 0-3 7578686-5 1995 When a submaximal dosage of CRH was given together with a maximal dosage of hCG, steroid production was stimulated even more highly in MA-10 cells. Steroids 81-88 corticotropin releasing hormone Mus musculus 28-31 10750673-2 2000 UGT2Bs are expressed in numerous human tissues, such as skin, breast, prostate, adipose, and intestine and are hypothesized to modulate steroid metabolism and excretion. Steroids 136-143 UDP-glucose glycoprotein glucosyltransferase 2 Homo sapiens 0-4 13904613-0 1962 The uptake and subcellular distribution of C-14-labeled steroid in rat ventral prostate following in vivo administration of testosterone-4-C-14. Steroids 56-63 anti-Mullerian hormone receptor type 2 Rattus norvegicus 139-143 10774266-1 2000 BACKGROUND: DHEAS, the most abundant steroid secreted by the adrenal cortex, is suggested to have an important role in the development of immune reaction by activating T cell function and increasing antibody response, and has been tried as a vaccine adjuvant in elderly people. Steroids 37-44 sulfotransferase family 2A member 1 Homo sapiens 12-17 7578686-10 1995 These results indicate that mouse Leydig cells respond to CRH through specific receptors with increased production of cAMP and steroids. Steroids 127-135 corticotropin releasing hormone Mus musculus 58-61 14497070-0 1961 [Influence of some pituitary hormones (ACTH, TSH, LTH, STH) and pituitary-like hormones (serum and chorionic gonadotropins) on the so-called urinary reducing-steroid quotient of normal individuals]. Steroids 158-165 saitohin Homo sapiens 55-58 7477946-15 1995 Moreover, the adrenal steroids have opposite effects on activity-dependent changes in brain-derived neurotrophic factor and nerve growth factor messenger RNA levels but are not required for the basic pattern of changes in neurotrophin messenger RNA expression elicited by recurrent seizures. Steroids 22-30 brain-derived neurotrophic factor Rattus norvegicus 86-119 10736099-5 2000 In two patients with active lupus, the percentage of CD59dim CD8+ T cells was significantly decreased after steroid therapy. Steroids 108-115 CD8a molecule Homo sapiens 61-64 13044786-0 1953 The enzymatic C-11 beta-hydroxylation of steroids. Steroids 41-49 endogenous retrovirus group K member 20 Homo sapiens 14-23 10666107-0 2000 Effect of steroid on hyperoxia-induced ICAM-1 expression in pulmonary endothelial cells. Steroids 10-17 intercellular adhesion molecule 1 Homo sapiens 39-45 10666107-2 2000 We studied the effect of steroid on hyperoxia-induced ICAM-1 expression using cultured endothelial cells in vitro. Steroids 25-32 intercellular adhesion molecule 1 Homo sapiens 54-60 7589785-5 1995 This recombinant cell line allowed determination of the substrate specificity and kinetic properties of this enzyme towards various steroid hormones, and by comparison of these activities with human liver cytosol we have shown that HST is the major sulphotransferase responsible for the sulphation of DHEA, androsterone and pregnenolone in man and that, functionally, the hepatic and adrenal enzymes are very similar. Steroids 132-148 sulfotransferase family 2A member 1 Homo sapiens 232-235 10650960-5 2000 The results show that the KA2-containing GnRH neurons also contain GluR5 receptor subunit mRNA and protein, and that these GnRH neurons are c-Fos positive during the steroid-induced LH surge. Steroids 166-173 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 140-145 34027892-8 2021 Mechanistically, suppressed synthetic phenotype and reduced proliferation were associated with decreased focal adhesion kinase/steroid receptor coactivator signaling and downstream targets, including phosphorylated ERK, p38 MAPK, glycogen synthase kinase 3beta, and nuclear beta-catenin, with reduced transcriptional activation of beta-catenin target genes. Steroids 127-134 catenin (cadherin associated protein), beta 1 Mus musculus 274-286 10627313-0 2000 Androgenic-anabolic steroids blunt morphine-induced c-fos expression in the rat striatum: possible role of beta-endorphin. Steroids 20-28 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 52-57 7542903-5 1995 The major role of PBR is in the regulation of steroid biosynthesis. Steroids 46-53 translocator protein Homo sapiens 18-21 7542903-6 1995 Various PBR ligands stimulate the conversion of cholesterol into pregnenolone and the production of steroid hormones. Steroids 100-116 translocator protein Homo sapiens 8-11 7626465-0 1995 Steroid regulation of parathyroid hormone-related protein expression and action in the rat uterus. Steroids 0-7 parathyroid hormone-like hormone Rattus norvegicus 22-57 7626465-1 1995 The gene encoding parathyroid hormone-related protein (PTHrP), an autocrine/paracrine inhibitor of vascular and nonvascular smooth muscle contractility, is regulated by hormonal steroids including estrogens (E2), 1,25-dihydroxy vitamin D (Vit D3) and glucocorticoids. Steroids 178-186 parathyroid hormone-like hormone Rattus norvegicus 18-53 7626465-1 1995 The gene encoding parathyroid hormone-related protein (PTHrP), an autocrine/paracrine inhibitor of vascular and nonvascular smooth muscle contractility, is regulated by hormonal steroids including estrogens (E2), 1,25-dihydroxy vitamin D (Vit D3) and glucocorticoids. Steroids 178-186 parathyroid hormone-like hormone Rattus norvegicus 55-60 34027892-8 2021 Mechanistically, suppressed synthetic phenotype and reduced proliferation were associated with decreased focal adhesion kinase/steroid receptor coactivator signaling and downstream targets, including phosphorylated ERK, p38 MAPK, glycogen synthase kinase 3beta, and nuclear beta-catenin, with reduced transcriptional activation of beta-catenin target genes. Steroids 127-134 catenin (cadherin associated protein), beta 1 Mus musculus 331-343 7626465-6 1995 Uterine horns were used to measure the effect of the steroids on the ability of PTHrP(1-34) to inhibit spontaneous myometrial contraction. Steroids 53-61 parathyroid hormone-like hormone Rattus norvegicus 80-85 10630920-9 2000 CONCLUSIONS: Changes in the concentrations of MDA, G6PD, and vitamin E are consistent with increased amounts of oxidation in steroid responsive nephrotic syndrome. Steroids 125-132 glucose-6-phosphate dehydrogenase Homo sapiens 51-55 34021411-4 2021 AQP4-Ab-positive optic neuritis responds poorly to steroid therapy and has a poor prognosis in terms of visual acuity. Steroids 51-58 aquaporin 4 Homo sapiens 0-4 7738515-1 1995 Cytochrome P450c17 is a key steroidogenic enzyme for the production of sex steroids in gonadal tissue and for cortisol production in adrenal tissue. Steroids 75-83 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 11-18 34016144-13 2021 The results of qRT-PCR demonstrated that CXCR1, FPR1, and TYROBP were upregulated while MAPK1 was downregulated in peripheral blood of steroid-induced ONFH patients. Steroids 135-142 C-X-C motif chemokine receptor 1 Homo sapiens 41-46 7583019-5 1995 Since individual subunits of AP-1 exhibit small differences in sequence specificity, specific subsets of AP-1-dependent genes may be regulated by steroid hormones in different directions. Steroids 146-162 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 29-33 34016144-16 2021 CXCR1, FPR1, TYROBP, and MAPK1 may be used as potential drug targets and biomarkers for the diagnosis and prognosis of steroid-induced ONFH. Steroids 119-126 C-X-C motif chemokine receptor 1 Homo sapiens 0-5 7583019-5 1995 Since individual subunits of AP-1 exhibit small differences in sequence specificity, specific subsets of AP-1-dependent genes may be regulated by steroid hormones in different directions. Steroids 146-162 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 105-109 33987731-6 2021 She was also on steroid inhalers. Steroids 16-23 Src homology 2 domain containing E Homo sapiens 0-3 7796156-1 1995 Gonadal steroid hormones are known to alter the expression of proopiomelanocortin (POMC) mRNA in neurons of the arcuate nucleus (ARC). Steroids 8-24 proopiomelanocortin Rattus norvegicus 62-81 7796156-1 1995 Gonadal steroid hormones are known to alter the expression of proopiomelanocortin (POMC) mRNA in neurons of the arcuate nucleus (ARC). Steroids 8-24 proopiomelanocortin Rattus norvegicus 83-87 10941806-2 2000 An increase was observed in the CD4/CD8 ratio as well as a decrease in the expression of HLA-DR on T cells with the improvement of clinical manifestations on treatment with steroids or cyclosporine (CSA). Steroids 173-181 CD8a molecule Homo sapiens 36-39 11187083-8 2000 Interestingly, we also found that steroids and retinoids can mimic anti-mu-mediated signaling and lead to a loss of c-Myc, an increase in p27Kip1, G1 arrest, and apoptosis. Steroids 34-42 cyclin-dependent kinase inhibitor 1B Mus musculus 138-145 33866437-8 2022 Changes in CXCL10 serum levels in patients treated with psoralen plus UVA (PUVA) phototherapy, narrowband UVB (NB-UVB) phototherapy, and systemic steroids (SS) correlated with changes in the intralesional CXCL10 levels in repigmented skin. Steroids 146-154 C-X-C motif chemokine ligand 10 Homo sapiens 11-17 10896204-3 2000 It deals with the pharmacological, structural and molecular characterization of the PBR, the proteins associated with the receptor (VDAC, ANC, PRAX-1) and their roles in cell growth and differentiation, cancer, steroid biosynthesis, and other physiological roles. Steroids 211-218 translocator protein Homo sapiens 84-87 7776978-9 1995 These findings indicate that the mouse calbindin-D28k promoter is capable of conferring estrogen responsiveness, which may be mediated by several imperfect half-palindromic estrogen-responsive elements, and suggest, in light of previous studies concerning 1,25-dihydroxyvitamin D regulation, multiple steroid regulation of the calbindin-D28k gene. Steroids 301-308 calbindin 1 Mus musculus 39-53 33866437-8 2022 Changes in CXCL10 serum levels in patients treated with psoralen plus UVA (PUVA) phototherapy, narrowband UVB (NB-UVB) phototherapy, and systemic steroids (SS) correlated with changes in the intralesional CXCL10 levels in repigmented skin. Steroids 146-154 C-X-C motif chemokine ligand 10 Homo sapiens 205-211 33935718-10 2021 GO and KEGG analysis showed that the dysregulated genes were mainly involved in biological processes and pathways, including "response to stimulus", "cellular response to organic substance", "regulation of signal transduction", "AGE-RAGE signaling pathway in diabetic complications", and "steroid hormone biosynthesis". Steroids 289-296 advanced glycosylation end-product specific receptor Homo sapiens 233-237 7726748-9 1995 These results suggest that the inhibition of ICAM-1 expression could be related to the pharmacological action of steroid drugs. Steroids 113-120 intercellular adhesion molecule 1 Homo sapiens 45-51 7588420-1 1995 The enzyme, 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase (3 beta-HSD) is an essential element in the biosynthetic pathway for potent adrenal steroid hormones that appear to regulate maturation of many tissues in utero and are critical for homeostasis after birth. Steroids 26-33 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 69-79 11455959-0 2000 Effects of steroid hormones on age-related expression and modulation of the lysozyme gene of the oviduct of Japanese quail. Steroids 11-27 lysozyme C Coturnix japonica 76-84 21312122-9 2000 Suppression of proinflammatory cytokine release, such as GM-CSF, IL-4, IL-5, and regulated upon activation, normal T-cell expressed and secreted (RANTES), from many inflammatory and resident airway cells, is a likely mechanism of steroid action (10-12). Steroids 230-237 C-C motif chemokine ligand 5 Homo sapiens 81-144 21312122-9 2000 Suppression of proinflammatory cytokine release, such as GM-CSF, IL-4, IL-5, and regulated upon activation, normal T-cell expressed and secreted (RANTES), from many inflammatory and resident airway cells, is a likely mechanism of steroid action (10-12). Steroids 230-237 C-C motif chemokine ligand 5 Homo sapiens 146-152 33857803-2 2021 Our previous studies have demonstrated that steroid receptor coactivator 3 (SRC-3) plays a critical protective role in host defense against extracellular bacterial pathogens such as Escherichia coli and Citrobacter rodentium. Steroids 44-51 nuclear receptor coactivator 3 Mus musculus 76-81 10611255-6 2000 P450 side-chain cleavage (P450scc) mRNA decreased in a time-dependent fashion up to 24 h, whereas 3beta-HSD mRNA increased within 12 h of HCG administration (P < 0.05) in a steroid-independent manner. Steroids 176-183 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 98-107 7835299-10 1995 We examined the ability of IGF-1, insulin, dexamethasone, sex steroids, and T4 to influence GHBP release. Steroids 62-70 growth hormone receptor Homo sapiens 92-96 8713981-7 1995 Substitution of membrane cholesterol with other steroids showed a strong dependence of the oxytocin receptor function on the structure of the cholesterol molecule. Steroids 48-56 oxytocin receptor Cavia porcellus 91-108 8713992-14 1995 These findings support the existence of a paracrine system within human decidua that involves sex steroids regulating synthesis of OT and that undergoes significant changes around the time of parturition. Steroids 98-106 oxytocin/neurophysin I prepropeptide Homo sapiens 131-133 7735299-2 1995 Intracerebroventricular (icv) administration or direct infusion of NPY into the median eminence (ime) suppresses GnRH release in ovariectomized (OVX) animals, but stimulates GnRH release in intact or OVX animals treated with ovarian steroids. Steroids 233-241 neuropeptide Y Macaca mulatta 67-70 7735299-8 1995 Without exception, ime infusion of NPY increased GnRH concentrations in push-pull perfusates regardless of the steroid status of the animals. Steroids 111-118 neuropeptide Y Macaca mulatta 35-38 10724337-0 2000 Synthesis and phosphorylation of androgen receptor of the mouse brain cortex and their regulation by sex steroids during aging. Steroids 105-113 androgen receptor Mus musculus 33-50 33539964-5 2021 Over the last decade, these C11-oxy C19 steroids have once again come to the fore with the rising number of studies contradicting the generally accepted notion that testosterone and it"s 5alpha-reduced product, dihydrotestosterone, are the principal potent androgens in humans. Steroids 40-48 aldo-keto reductase family 1 member C4 Homo sapiens 28-31 10724337-1 2000 To examine the synthesis and phosphorylation of androgen receptor (AR) and their regulation by sex steroids, adult (24 weeks) and old (65 weeks) male and female mice were gonadectomized and administered with testosterone and estradiol. Steroids 99-107 androgen receptor Mus musculus 67-69 7740159-1 1995 During the development of preovulatory follicles, tonic levels of FSH (and steroid) induce expression of aromatase, the LH receptor, and RII beta in a coordinate manner. Steroids 75-82 protein kinase cAMP-dependent type II regulatory subunit beta Homo sapiens 137-145 7802648-0 1994 Steroid hormone modulation of vitamin D receptor levels in human MG-63 osteosarcoma cells. Steroids 0-15 vitamin D receptor Homo sapiens 30-48 7888504-0 1994 A reduced proportion of luteinizing hormone (LH)-releasing hormone neurons express Fos protein during the preovulatory or steroid-induced LH surge in middle-aged rats. Steroids 122-129 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-86 7888504-4 1994 The mean proportion of LHRH neurons containing immunoreactive Fos was higher in the brains of young compared to middle-aged females in association with both the preovulatory (p < 0.01) and the steroid-induced LH surge (p < 0.001). Steroids 196-203 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 62-65 33539964-7 2021 In this review, we will highlight these overlooked C11-oxy C19 steroids as well as the C11-oxy C21 steroids and their contribution to congenital adrenal hyperplasia, polycystic ovarian syndrome and prostate cancer. Steroids 63-71 aldo-keto reductase family 1 member C4 Homo sapiens 51-54 11155790-13 2000 Since DHEAS is the pool for peripheral sex steroids, such as testosterone and 17 beta-estradiol, lack of this hormone leads to a significant sex hormone deficiency in the periphery. Steroids 43-51 sulfotransferase family 2A member 1 Homo sapiens 6-11 33539964-7 2021 In this review, we will highlight these overlooked C11-oxy C19 steroids as well as the C11-oxy C21 steroids and their contribution to congenital adrenal hyperplasia, polycystic ovarian syndrome and prostate cancer. Steroids 99-107 aldo-keto reductase family 1 member C4 Homo sapiens 87-90 7714141-5 1994 GH receptor immunoreactivity was observed in luteinized granulosa cells in corpora lutea in the luteal phase, which are considered to be active in steroid production. Steroids 147-154 growth hormone receptor Homo sapiens 0-11 33981943-11 2021 Metabolite profile differences for MFGM+LF versus control included lower fecal medium-chain fatty acids, deoxycarnitine, and glycochenodeoxycholate, and some higher fecal carbohydrates and steroids (P < 0.05). Steroids 189-197 milk fat globule EGF and factor V/VIII domain containing Bos taurus 35-39 7729809-2 1994 Further studies suggest that NPY neurons may mediate the action of steroid hormones. Steroids 67-83 neuropeptide Y Macaca mulatta 29-32 7729809-9 1994 These results suggest that in vivo LHRH release is modulated by NPY, NE, and GABA neuronal inputs which mediate the action of steroid hormones. Steroids 126-142 neuropeptide Y Macaca mulatta 64-67 7865477-2 1994 Autoantibodies against annexin-1 have been reported in association with autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis and their presence has been hypothesized as the reason for the steroid resistance phenomenon. Steroids 217-224 annexin A1 Homo sapiens 23-32 10610719-9 1999 Zyme is regulated by steroid hormones in the breast carcinoma cell line BT-474. Steroids 21-28 kallikrein related peptidase 6 Homo sapiens 0-4 10651224-0 1999 The changes of serum soluble intercellular adhesion molecule-1 after systemic steroid treatment in vitiligo. Steroids 78-85 intercellular adhesion molecule 1 Homo sapiens 29-62 10638200-5 1999 These data suggest that SR-B1 plays important roles in steroid hormone production. Steroids 55-70 scavenger receptor class B member 1 Homo sapiens 24-29 33784266-11 2021 However, further research is required to clarify how KISS1 regulates proliferation and steroid production in luteal cells. Steroids 87-94 metastasis-suppressor KiSS-1 Capra hircus 53-58 10517906-2 1999 AIMS: To identify whether the adhesion molecule, intercellular adhesion molecule 1 (ICAM-1), or the chemokine KC could be targeted by the steroid to mediate its antiadhesive effect. Steroids 138-145 intercellular adhesion molecule 1 Rattus norvegicus 49-82 10517906-2 1999 AIMS: To identify whether the adhesion molecule, intercellular adhesion molecule 1 (ICAM-1), or the chemokine KC could be targeted by the steroid to mediate its antiadhesive effect. Steroids 138-145 intercellular adhesion molecule 1 Rattus norvegicus 84-90 7828346-14 1994 Both these residues are conserved in the steroid/thyroid hormone receptor superfamily and stereochemical analysis has been used to deduce the importance of these amino acids and the deleterious effect of these and other mutations in the DNA-binding domain of the VDR. Steroids 41-48 vitamin D receptor Homo sapiens 263-266 33781417-3 2021 Certain steroid hormones (progestogens, estrogens) and fetal proteins (alpha-fetoprotein; AFP) might improve the diagnostics for abnormal pregnancy, but the utility of these markers in the field is unknown. Steroids 8-15 alpha fetoprotein Equus caballus 71-88 7840424-7 1994 Autoradiographic localization of PBR obtained by incubating ovary sections with [3H] PK11195, a ligand selective for PBR, revealed the presence of specific labelling in all the steroid-secreting cells. Steroids 177-184 translocator protein Rattus norvegicus 33-36 7840424-8 1994 These results, which demonstrate for the first time that the ovarian steroid-secreting cells contain both PBR and its endogenous ligand, suggest that the BZD receptor might be involved in the regulation of ovarian function. Steroids 69-76 translocator protein Rattus norvegicus 106-109 10508124-5 1999 Recently, it has been demonstrated that hK2 is expressed in the breast cancer cell line T-47D after stimulation by steroid hormones, and we reported that hK2 can be detected in a subset of breast tumor extracts. Steroids 115-131 RBPJ pseudogene 3 Homo sapiens 40-43 10499513-1 1999 The 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) isoenzymes catalyze an essential step in the formation of all classes of active steroid hormones. Steroids 141-157 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 4-48 10499513-1 1999 The 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) isoenzymes catalyze an essential step in the formation of all classes of active steroid hormones. Steroids 141-157 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 50-59 10499513-4 1999 The present study was designed to investigate whether such a cytokine-induced 3beta-HSD type 1 expression would also be observed in cell types derived from other peripheral sex steroid target tissues. Steroids 177-184 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 78-87 10520127-0 1999 Immunoreactive neurotensin in gonadotrophs and thyrotrophs is regulated by sex steroid hormones in the female rat. Steroids 79-95 neurotensin Rattus norvegicus 15-26 33076783-2 2021 Liganded TR recruit coactivator complexes that include steroid receptor coactivators (SRC1, SRC2 or SRC3), which are histone acetyltransferases, to T3 responsive promoters. Steroids 55-62 nuclear receptor coactivator 2 Xenopus tropicalis 92-96 33076783-2 2021 Liganded TR recruit coactivator complexes that include steroid receptor coactivators (SRC1, SRC2 or SRC3), which are histone acetyltransferases, to T3 responsive promoters. Steroids 55-62 nuclear receptor coactivator 3 Xenopus tropicalis 100-104 33279474-4 2021 The demonstration that the vitamin D receptor (VDR) is ubiquitously, expressed combined with increasing observational data supporting a relationship between the level of 25-hydroxy-vitamin D in the serum and chronic metabolic disorders, cardiovascular disease and neoplasms, have led to its redefinition as a steroid hormone and the proposal of its use in preventing and/or treating those diseases. Steroids 309-316 vitamin D receptor Homo sapiens 27-45 10530702-0 1999 Angiostatic activity of steroids in the chick embryo CAM and rabbit cornea models of neovascularization. Steroids 24-32 calmodulin 2 Gallus gallus 53-56 10530702-5 1999 There was a good correlation between the angiostatic efficacies of 15 diverse steroids tested in the chick CAM and in the rabbit LPS-induced corneal pocket models of neovascularization (r=0.76, p=0.01). Steroids 78-86 calmodulin 2 Gallus gallus 107-110 10580842-0 1999 Steroid-induced conformational changes of rat glucocorticoid receptor cause altered trypsin cleavage of the putative helix 6 in the ligand binding domain. Steroids 0-7 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 46-69 10580842-7 1999 This was supported by the observation that trypsin digestion of the steroid-free R651A mutant GR gave rise to the 30-kDa meroreceptor (amino acids 518-795), which displayed wild type affinity. Steroids 68-75 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 94-96 33279474-4 2021 The demonstration that the vitamin D receptor (VDR) is ubiquitously, expressed combined with increasing observational data supporting a relationship between the level of 25-hydroxy-vitamin D in the serum and chronic metabolic disorders, cardiovascular disease and neoplasms, have led to its redefinition as a steroid hormone and the proposal of its use in preventing and/or treating those diseases. Steroids 309-316 vitamin D receptor Homo sapiens 47-50 10580842-8 1999 This 30-kDa species is thus the smallest non-associated fragment of GR possessing wild type steroid binding affinity. Steroids 92-99 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 68-70 10580842-11 1999 However, unlike the estrogen receptor or the more closely related progesterone receptor, the precise proteolytic cleavage points of both the steroid-free and -bound GR fall within regions that are predicted, on the basis of X-ray crystal structures of related receptors, to be alpha-helical and resistant to proteolysis. Steroids 141-148 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 165-167 33561833-9 2021 Following her treatment with oral steroids, her symptoms and CK level improved. Steroids 34-42 cytidine/uridine monophosphate kinase 1 Homo sapiens 61-63 10645254-5 1999 Experiment 2 was conducted to determine the effects of exogenous steroids on endometrial ER alpha and PR mRNAs. Steroids 65-73 estrogen receptor 1 Equus caballus 89-97 10645254-7 1999 The steroid treatment affected the abundance of ER alpha mRNA (P = 0.0420), which was higher (P < 0.05) in the oestradiol group than in the group treated with oestradiol followed by long duration progesterone. Steroids 4-11 estrogen receptor 1 Equus caballus 48-56 10645254-9 1999 These results demonstrate that the amount of steroid receptor mRNA changes with the fluctuating steroid environment in the uterine endometrium of cyclic and early pregnant mares, and that the duration of progesterone dominance may affect ER alpha gene expression. Steroids 45-52 estrogen receptor 1 Equus caballus 238-246 32388823-10 2021 Furthermore, the GO and KEGG analysis indicated that GX II acted on CHD by regulating the reactive oxygen species metabolism, steroid metabolism, lipid metabolism, inflammatory response, proliferation, differentiation and apoptosis. Steroids 126-133 phospholipase A2 group XIIA Homo sapiens 53-58 10415106-1 1999 An orphan nuclear receptor, termed the pregnane X receptor (PXR), has recently been cloned from mouse and human and defines a novel steroid signaling pathway (Cell 92, 73-82, 1998; Proc. Steroids 132-139 nuclear receptor subfamily 1, group I, member 2 Mus musculus 39-58 10415106-1 1999 An orphan nuclear receptor, termed the pregnane X receptor (PXR), has recently been cloned from mouse and human and defines a novel steroid signaling pathway (Cell 92, 73-82, 1998; Proc. Steroids 132-139 nuclear receptor subfamily 1, group I, member 2 Mus musculus 60-63 33140199-0 2021 Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial. Steroids 19-26 adrenomedullin Homo sapiens 0-14 10668635-1 1999 Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, are the most abundant steroids in the human circulation, although their exact biological significance is not completely understood. Steroids 82-90 sulfotransferase family 2A member 1 Homo sapiens 53-58 32870362-12 2021 Upregulation of stabilin-1 in CD163+ M2 MPhi was confirmed in biopsies from S group. Steroids 76-77 stabilin 1 Homo sapiens 16-26 10411704-7 1999 RESULTS: The recipient TNF-alpha high producer genotype and IL-10 high producer genotype were significantly associated with multiple REs (>/=2) in human leukocyte antigen (HLA)-DR mismatched transplants (P = 0.0047 and P = 0.045, respectively), whereas only the TNF-alpha high producer genotype was associated with steroid-resistant REs (P = 0.025). Steroids 318-325 interleukin 10 Homo sapiens 60-65 32870362-12 2021 Upregulation of stabilin-1 in CD163+ M2 MPhi was confirmed in biopsies from S group. Steroids 76-77 CD163 molecule Homo sapiens 30-35 33510532-6 2021 The high adenosine deaminase level in pericardial fluid analysis was suggestive of tuberculosis for which she was treated with antitubercular therapy and steroid. Steroids 154-161 adenosine deaminase Homo sapiens 9-28 10387026-1 1999 Fluorescence stopped-flow studies were conducted with recombinant rat liver 3 alpha-HSD, an aldo-keto reductase (AKR) that plays critical roles in steroid hormone inactivation, to characterize the binding of nicotinamide cofactor, the first step in the kinetic mechanism. Steroids 147-162 aldo-keto reductase family 1, member C14 Rattus norvegicus 76-87 33454992-7 2021 The results of our study suggest that Res prevents steroid-induced osteonecrosis by upregulating miR-146a, and thereby stabilizes osteogenesis/osteoclastogenesis homeostasis via Wnt/FOXO and Sirt1/NF-kappaB pathways. Steroids 51-58 sirtuin 1 Homo sapiens 191-196 10401698-0 1999 Effect of ovarian steroids and oxytocin on the production of prostaglandin E2, prostaglandin F2alpha and endothelin-1 from cow oviductal epithelial cell monolayers in vitro. Steroids 18-26 endothelin 1 Bos taurus 105-117 33007359-2 2020 The MR is a steroid receptor in the same family as the glucocorticoid receptor, with which it shares the ligand corticosterone in addition to the MR selective ligand aldosterone. Steroids 12-19 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 55-78 10218971-11 1999 We postulate that ovarian steroid regulation of CRH synthesis and release may in part explain the central nervous system mechanisms by which ovarian steroids affect the HPA and HPO axes during basal and stress conditions. Steroids 26-33 corticotropin releasing hormone Macaca mulatta 48-51 10218971-11 1999 We postulate that ovarian steroid regulation of CRH synthesis and release may in part explain the central nervous system mechanisms by which ovarian steroids affect the HPA and HPO axes during basal and stress conditions. Steroids 149-157 corticotropin releasing hormone Macaca mulatta 48-51 10320829-0 1999 Differential involvement of adrenal and gonadal steroids in anterior and intermediate pituitary pro-opiomelanocortin mRNA expression induced by the endogenous benzodiazepine, octadecaneuropeptide, in adult male rats. Steroids 48-56 proopiomelanocortin Rattus norvegicus 96-116 10320829-9 1999 These studies indicate that, in vivo, the decrease in POMC mRNA expression in the anterior and intermediate pituitary induced by an endogenous benzodiazepine is differently modulated by adrenal and gonadal steroids, with a predominant influence of adrenal steroids at the anterior pituitary level and gonadal steroids at the intermediate pituitary level. Steroids 206-214 proopiomelanocortin Rattus norvegicus 54-58 10320829-9 1999 These studies indicate that, in vivo, the decrease in POMC mRNA expression in the anterior and intermediate pituitary induced by an endogenous benzodiazepine is differently modulated by adrenal and gonadal steroids, with a predominant influence of adrenal steroids at the anterior pituitary level and gonadal steroids at the intermediate pituitary level. Steroids 256-264 proopiomelanocortin Rattus norvegicus 54-58 33318259-4 2020 Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. Steroids 204-212 leucine rich glioma inactivated 1 Homo sapiens 109-142 10320829-9 1999 These studies indicate that, in vivo, the decrease in POMC mRNA expression in the anterior and intermediate pituitary induced by an endogenous benzodiazepine is differently modulated by adrenal and gonadal steroids, with a predominant influence of adrenal steroids at the anterior pituitary level and gonadal steroids at the intermediate pituitary level. Steroids 256-264 proopiomelanocortin Rattus norvegicus 54-58 33287384-4 2020 Since RACK1 is a relevant EDCs target that responds to steroid-active compounds, it could be considered a molecular bridge between the endocrine-regulated tumour microenvironment and the innate immune system. Steroids 55-62 receptor for activated C kinase 1 Homo sapiens 6-11 10228007-2 1999 Transfer of thymocyte suspensions depleted of CD25+4+8- thymocytes, which constitute approximately 5% of steroid-resistant mature CD4+8- thymocytes in normal naive mice, produces various autoimmune diseases in syngeneic athymic nude mice. Steroids 105-112 interleukin 2 receptor, alpha chain Mus musculus 46-50 33158965-2 2020 GH-releasing hormone (GHRH) neurons express estrogen receptor alpha (ERalpha) and androgen receptor (AR), suggesting changing levels of gonadal steroids during puberty directly modulate the somatotropic axis. Steroids 144-152 androgen receptor Mus musculus 82-99 10200428-15 1999 The present study shows that (i) Rnd1 inhibits agonist- and GTPgammaS-induced Ca2+ sensitization of smooth muscle by specifically interfering with a RhoA-dependent mechanism and (ii) an increase in Rnd1 expression may account, at least in part, for the steroid-induced decrease in agonist-induced Ca2+ sensitization. Steroids 253-260 Rho family GTPase 1 Rattus norvegicus 33-37 33158965-8 2020 Our findings demonstrate that direct actions of gonadal steroids in GHRH neurons modulate growth and puberty and indicate that GHRH/Kiss1 dual phenotype neurons play a sex-specific role in the crosstalk between the somatotropic and gonadotropic axes during pubertal transition.Significance Statement:Late maturing adolescents usually show delayed growth and bone age. Steroids 56-64 KiSS-1 metastasis-suppressor Mus musculus 132-137 10200428-15 1999 The present study shows that (i) Rnd1 inhibits agonist- and GTPgammaS-induced Ca2+ sensitization of smooth muscle by specifically interfering with a RhoA-dependent mechanism and (ii) an increase in Rnd1 expression may account, at least in part, for the steroid-induced decrease in agonist-induced Ca2+ sensitization. Steroids 253-260 ras homolog family member A Rattus norvegicus 149-153 10200428-15 1999 The present study shows that (i) Rnd1 inhibits agonist- and GTPgammaS-induced Ca2+ sensitization of smooth muscle by specifically interfering with a RhoA-dependent mechanism and (ii) an increase in Rnd1 expression may account, at least in part, for the steroid-induced decrease in agonist-induced Ca2+ sensitization. Steroids 253-260 Rho family GTPase 1 Rattus norvegicus 198-202 33290750-6 2020 Moreover, the expression of steroid metabolism-related genes (3betaHSD, Cyp11a1, StAR and Cyp19a1) in these two groups was down-regulated, with lower levels of estradiol (E2) and progesterone (P). Steroids 28-35 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 62-70 10212276-3 1999 Surprisingly, the expression of MTP in membranes of an intracellular compartment resulted in a cellular resistance or hypersensitivity to a range of drugs that included nucleoside and nucleobase analogs, antibiotics, anthracyclines, ionophores, and steroid hormones. Steroids 249-265 microsomal triglyceride transfer protein Homo sapiens 32-35 10212276-4 1999 The intracellular bioavailability of steroid hormones was altered by MTP, as determined using an in vivo glucocorticoid receptor-driven reporter assay in yeast, suggesting that the MTP-regulated drug sensitivity arose due to a change in the subcellular compartmentalization of steroid hormones and other drugs. Steroids 37-53 microsomal triglyceride transfer protein Homo sapiens 69-72 33205494-2 2021 Although it is thought that TSPO plays key roles in a multitude of host cell functions, including steroid biosynthesis, apoptosis, generation of reactive oxygen species, and proliferation, some of these functions have recently been questioned. Steroids 98-105 translocator protein Homo sapiens 28-32 10212276-4 1999 The intracellular bioavailability of steroid hormones was altered by MTP, as determined using an in vivo glucocorticoid receptor-driven reporter assay in yeast, suggesting that the MTP-regulated drug sensitivity arose due to a change in the subcellular compartmentalization of steroid hormones and other drugs. Steroids 37-53 microsomal triglyceride transfer protein Homo sapiens 181-184 10212276-4 1999 The intracellular bioavailability of steroid hormones was altered by MTP, as determined using an in vivo glucocorticoid receptor-driven reporter assay in yeast, suggesting that the MTP-regulated drug sensitivity arose due to a change in the subcellular compartmentalization of steroid hormones and other drugs. Steroids 277-293 microsomal triglyceride transfer protein Homo sapiens 69-72 10212276-4 1999 The intracellular bioavailability of steroid hormones was altered by MTP, as determined using an in vivo glucocorticoid receptor-driven reporter assay in yeast, suggesting that the MTP-regulated drug sensitivity arose due to a change in the subcellular compartmentalization of steroid hormones and other drugs. Steroids 277-293 microsomal triglyceride transfer protein Homo sapiens 181-184 10213192-13 1999 The area-specific coexpression of AR, ER, and ARO suggests various possibilities for the steroid-dependent regulation of ARO and for the role of ARO in controlling AR- and ER-dependent mechanisms. Steroids 89-96 estrogen receptor Taeniopygia guttata 38-40 32980349-1 2020 Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport chain that includes NADPH, NADPH-adrenodoxin reductase (AdR), and adrenodoxin (Adx) instead of the diflavin NADPH-P450 reductase (POR) used by the other P450s in the endoplasmic reticulum. Steroids 110-118 2,4-dienoyl-CoA reductase 1 Homo sapiens 209-214 10216261-1 1999 Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental area (VTA). Steroids 95-102 nuclear receptor subfamily 4 group A member 2 Homo sapiens 34-39 32980349-1 2020 Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport chain that includes NADPH, NADPH-adrenodoxin reductase (AdR), and adrenodoxin (Adx) instead of the diflavin NADPH-P450 reductase (POR) used by the other P450s in the endoplasmic reticulum. Steroids 110-118 ferredoxin 1 Homo sapiens 222-233 32980349-1 2020 Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport chain that includes NADPH, NADPH-adrenodoxin reductase (AdR), and adrenodoxin (Adx) instead of the diflavin NADPH-P450 reductase (POR) used by the other P450s in the endoplasmic reticulum. Steroids 110-118 ferredoxin 1 Homo sapiens 268-271 32554042-0 2020 Common risk variants in NPHS1 and TNFSF15 are associated with childhood steroid-sensitive nephrotic syndrome. Steroids 72-79 NPHS1 adhesion molecule, nephrin Homo sapiens 24-29 10216261-1 1999 Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental area (VTA). Steroids 95-102 nuclear receptor subfamily 4 group A member 2 Homo sapiens 59-64 10216261-1 1999 Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental area (VTA). Steroids 95-102 mitochondrially encoded 12S RNA Homo sapiens 65-70 10216261-1 1999 Recent reports have revealed that Nurr1 (also known as NOT/TINUR/RNR-1/HZF-3), a member of the steroid/thyroid hormone nuclear receptor superfamily, is predominantly expressed in the midbrain; substantia nigra (SN) and ventral tegmental area (VTA). Steroids 95-102 nuclear receptor subfamily 4 group A member 2 Homo sapiens 71-76 33305262-8 2020 We found that the cytochrome P450 46A1-dependent efavirenz effects included changes in the levels of brain sterols, steroid hormones, and such proteins as glial fibrillary acidic protein, Iba1, Munc13-1, post-synaptic density-95, gephyrin, synaptophysin and synapsin-1. Steroids 116-123 cytochrome P450, family 46, subfamily a, polypeptide 1 Mus musculus 18-38 10233845-0 1999 Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. Steroids 144-151 MpV17 mitochondrial inner membrane protein Mus musculus 48-53 10233845-6 1999 These results indicate that the glomerular disease in Mpv17-/- mice qualifies as a model of steroid-resistant focal segmental glomerulosclerosis and that experimental therapies with scavengers of oxygen radicals and lipid peroxidation efficiently ameliorate glomerular damage. Steroids 92-99 MpV17 mitochondrial inner membrane protein Mus musculus 54-59 33305262-11 2020 In contrast, altered transcription of genes from cholinergic, monoaminergic, and peptidergic neurotransmission, steroid sulfation and production as well as vitamin D3 activation was the main CYP46A1-independent efavirenz effect. Steroids 112-119 cytochrome P450, family 46, subfamily a, polypeptide 1 Mus musculus 191-198 33305262-12 2020 Collectively, the data obtained reveal that CYP46A1 controls cholesterol availability for the production of steroid hormones in the brain and the levels of biologically active neurosteroids. Steroids 108-115 cytochrome P450, family 46, subfamily a, polypeptide 1 Mus musculus 44-51 10353094-12 1999 Asthmatics on low doses of inhaled steroids had increased ECP levels in sputum and serum, indicating persistent eosinophilic inflammation of the airways. Steroids 35-43 ribonuclease A family member 3 Homo sapiens 58-61 33305125-6 2020 Steroid treatment was associated with a significant improvement in eGFR versus no steroids in C3G (mean +43.0 (range 12.9-73.0) vs. -3.0 (range -23.1 to 17.2) ml/min per 1.73 m2, P = 0.02) but not in IC-MPGN. Steroids 0-7 Rap guanine nucleotide exchange factor 1 Homo sapiens 94-97 9988410-10 1999 CONCLUSION(S): Human endometrium expresses mRNA for several integrins and fibronectin, with up-regulation of alpha4, alpha v, beta1, and beta3 during the secretory phase of the menstrual cycle, suggesting that their differential expression may be regulated in part by ovarian steroids. Steroids 276-284 immunoglobulin binding protein 1 Homo sapiens 109-142 32868907-2 2020 LSD1 (KDM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K4me1/2)5,6, but also acts as a steroid hormone receptor coactivator through mechanisms that are unclear. Steroids 139-146 lysine demethylase 1A Homo sapiens 0-4 10202863-1 1999 The effects of ovarian steroids on the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in rat uterus were examined. Steroids 23-31 colony stimulating factor 2 Rattus norvegicus 53-101 32868907-2 2020 LSD1 (KDM1A) acts as a transcriptional repressor by demethylating mono/dimethylated histone H3 lysine 4 (H3K4me1/2)5,6, but also acts as a steroid hormone receptor coactivator through mechanisms that are unclear. Steroids 139-146 lysine demethylase 1A Homo sapiens 6-11 10202863-1 1999 The effects of ovarian steroids on the expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) in rat uterus were examined. Steroids 23-31 colony stimulating factor 2 Rattus norvegicus 103-109 10202863-6 1999 These data suggest that the expression of GM-CSF in uterine stromal cells is partially regulated by ovarian steroids. Steroids 108-116 colony stimulating factor 2 Rattus norvegicus 42-48 32710236-3 2020 Collectins- surfactant protein A (SP-A), surfactant protein D (SP-D), and mannose-binding lectin (MBL) are a group of innate immune molecules regulated by the steroid hormones. Steroids 159-166 surfactant protein D Homo sapiens 63-67 10079704-1 1999 Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription. Steroids 53-68 vitamin D receptor Homo sapiens 174-192 10079704-1 1999 Calcitriol, the active metabolite of vitamin D, is a steroid hormone that regulates calcium metabolism and cell differentiation by interacting with its nuclear receptor--the vitamin D receptor (VDR)--and by stimulating gene transcription. Steroids 53-68 vitamin D receptor Homo sapiens 194-197 32994923-6 2020 Chronic steroid use not only predisposes to the development of NF but also may mask early features delaying presentation and diagnosis. Steroids 8-15 neurofascin Homo sapiens 63-65 10403489-1 1999 Dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) are the most abundant steroidal products and major circulating steroids in humans. Steroids 118-126 sulfotransferase family 2A member 1 Homo sapiens 47-53 10625069-16 1999 Dehydroepiandrosterone implants had no clear-cut effects on any immunostaining following acute stress, though there was a trend towards lessened adaptation of the Fos response in the septum after steroid treatment. Steroids 196-203 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 163-166 9928172-5 1998 Galanin-expressing perikarya in the medial preoptic area (MPOA) have a similar function, although GAL here operates in association with the female steroids estrogen and progesterone. Steroids 147-155 galanin and GMAP prepropeptide Homo sapiens 98-101 9830022-7 1998 OCT3 is inhibited by several steroids, and beta-estradiol is the most potent inhibitor (Ki approximately 1 microM). Steroids 29-37 solute carrier family 22 member 3 Homo sapiens 0-4 9830022-8 1998 The pattern of steroid sensitivity of OCT3 is different from that of OCT1 and OCT2 but correlates significantly with that of the extraneuronal monoamine transporter (uptake2). Steroids 15-22 solute carrier family 22 member 3 Homo sapiens 38-42 9830022-9 1998 The transport characteristics and steroid sensitivity provide strong evidence for the molecular identity of OCT3 as uptake2. Steroids 34-41 solute carrier family 22 member 3 Homo sapiens 108-112 9832418-1 1998 Steroidogenic acute regulatory (StAR) protein is synthesized in response to tropic hormones to facilitate cholesterol transport to the inner mitochondrial membrane-bound P450 side-chain cleavage enzyme (P450scc), the first enzymatic step in the steroid hormone biosynthetic pathway. Steroids 245-260 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 170-201 9832418-1 1998 Steroidogenic acute regulatory (StAR) protein is synthesized in response to tropic hormones to facilitate cholesterol transport to the inner mitochondrial membrane-bound P450 side-chain cleavage enzyme (P450scc), the first enzymatic step in the steroid hormone biosynthetic pathway. Steroids 245-260 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 203-210 10070321-3 1998 The stimulatory effect of EGF on cell division was effectively counteracted by 1,25(OH)2D3: the presence of the steroid hormone prevents the negative effect of EGF on vitamin D receptor abundance and concurrently minimises ligand-occupied EGF receptor numbers on both sides of Caco-2 cell monolayers. Steroids 112-127 vitamin D receptor Homo sapiens 167-185 9881968-5 1998 Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages. Steroids 96-103 CD4 antigen Mus musculus 159-162 9847438-14 1998 The effect of dexamethasone on the IL-4Ralpha was steroid specific because it was totally reversed by the glucocorticoid receptor antagonist RU486. Steroids 50-57 interleukin 4 receptor Homo sapiens 35-45 9834464-4 1998 The objectives of this study were to determine whether a gonadal steroid implant (20 mg estrogen and 200 mg progesterone) given to endotoxemic steers would: (1) reduce hyperglycemia, reduce hypoglycemia, reduce insulin resistance, (2) reduce changes in concentrations of GH and IGF-I, (3) reduce inappetence and reduce concentrations of blood urea nitrogen (BUN) and non-esterified fatty acids (NEFA), and (4) reduce fever and concentrations of TNFalpha and cortisol. Steroids 65-72 IGFI Bos taurus 278-283 9834464-10 1998 05) at 6 and 24 h. Concentrations of IGF-I were restored earlier in steroid-treated steers than in controls. Steroids 68-75 IGFI Bos taurus 37-42 9834464-16 1998 Furthermore, concentrations of IGF-I are restored earlier in steroid-treated than in non-steroid-treated steers injected with LPS. Steroids 61-68 IGFI Bos taurus 31-36 9834464-16 1998 Furthermore, concentrations of IGF-I are restored earlier in steroid-treated than in non-steroid-treated steers injected with LPS. Steroids 89-96 IGFI Bos taurus 31-36 9849867-0 1998 Albumin"s role in steroid hormone action and the origins of vertebrates: is albumin an essential protein? Steroids 18-33 albumin Rattus norvegicus 0-7 9849867-1 1998 Albumin, the major serum protein, binds a wide variety of lipophilic compounds including steroids, other lipophilic hormones and phytochemicals that bind to hormone receptors. Steroids 89-97 albumin Rattus norvegicus 0-7 9849867-3 1998 However, due to albumin"s high concentration in serum, albumin is a major carrier of steroids and lipophilic hormones and regulator of their access to their receptors. Steroids 85-93 albumin Rattus norvegicus 16-23 9849867-3 1998 However, due to albumin"s high concentration in serum, albumin is a major carrier of steroids and lipophilic hormones and regulator of their access to their receptors. Steroids 85-93 albumin Rattus norvegicus 55-62 9784494-6 1998 SXR forms a heterodimer with RXR that can bind to and induce transcription from response elements present in steroid-inducible cytochrome P-450 genes and is expressed in tissues in which these catabolic enzymes are expressed. Steroids 109-116 retinoid X receptor alpha Homo sapiens 29-32 9792328-0 1998 Role of endogenous opiates in glucoprivic inhibition of the luteinizing hormone surge and fos expression by preoptic gonadotropin-releasing hormone neurones in ovariectomized steroid-primed female rats. Steroids 175-182 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 90-93 9761794-0 1998 The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. Steroids 67-74 cell elongation protein / DWARF1 / DIMINUTO (DIM) Arabidopsis thaliana 25-31 9729352-7 1998 This suggests that the NR2A subunit controls the efficacy of neurosteroid enhancement, but not inhibition, which is consistent with our previous finding that potentiating and inhibitory steroids act at distinct sites on the NMDA receptor. Steroids 186-194 glutamate receptor ionotropic, NMDA 2A-like Xenopus laevis 23-27 9888542-0 1998 Leptin down-regulates the steroid producing system in the adrenal. Steroids 26-33 leptin Bos taurus 0-6 9888542-6 1998 We therefore suggest that leptin reduces cortisol synthesis in the adrenal by down-regulating the steroid producing enzyme cascade in the cortical cell. Steroids 98-105 leptin Bos taurus 26-32 9893760-2 1998 By contrast, in patients with steroid-resistant asthma (SRA), this proliferative response is only partially attenuated by steroids, which suggests that the T lymphocyte may harbour a key molecular defect in these patients. Steroids 122-130 steroid receptor RNA activator 1 Homo sapiens 56-59 9645683-2 1998 Adrenal steroids act through two receptor subtypes, the glucocorticoid receptor (GR) and the mineralocorticoid receptor, and activation of each receptor subtype has distinct biochemical and physiological consequences. Steroids 8-16 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 56-79 9645683-2 1998 Adrenal steroids act through two receptor subtypes, the glucocorticoid receptor (GR) and the mineralocorticoid receptor, and activation of each receptor subtype has distinct biochemical and physiological consequences. Steroids 8-16 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 81-83 9719418-5 1998 In experiment one, steroid-treated (estradiol, progesterone, or estradiol + progesterone) polarized UE cells were treated with interferon tau (IFNtau) and/or oxytocin (OT). Steroids 19-26 oxytocin/neurophysin I prepropeptide Homo sapiens 158-166 9623608-7 1998 Such molecules, together with CSF-1, may play a role in modulating the complexities of uterine macrophage dynamics in response to sex steroid hormones and mating. Steroids 134-150 colony stimulating factor 1 (macrophage) Mus musculus 30-35 9630494-3 1998 In the present study, we evaluated the effect of chronic treatment with ovarian steroids on the expression of rat brain vesicular monoamine transporter (VMAT2). Steroids 80-88 solute carrier family 18 member A2 Rattus norvegicus 153-158 9630494-9 1998 It appears that ovarian steroids may play a crucial role in the regulation of VMAT2 gene expression in the dopamine and serotonin systems. Steroids 24-32 solute carrier family 18 member A2 Rattus norvegicus 78-83 9632923-6 1998 Influence of cytokine production may open new therapeutic approach, e.g. IL-10 enema proved to be effective in the treatment of some cases of steroid-resistant ulcerative colitis, while intravenous administration was useful in Crohn"s disease. Steroids 142-149 interleukin 10 Homo sapiens 73-78 9630160-6 1998 Our results show that 7 out of the 9 patients studied displayed increased IL-10 mRNA expression as well as higher serum IL-10 concentration following steroid treatment. Steroids 150-157 interleukin 10 Homo sapiens 120-125 9630160-9 1998 Peak responses of secreted IL-10 by PBMC cultured cells treated with MP were obtained at 48 h. The effect was steroid-specific as IL-10 expression reversed to baseline levels in the presence of the glucocorticoid receptor antagonist RU486. Steroids 110-117 interleukin 10 Homo sapiens 27-32 9630160-9 1998 Peak responses of secreted IL-10 by PBMC cultured cells treated with MP were obtained at 48 h. The effect was steroid-specific as IL-10 expression reversed to baseline levels in the presence of the glucocorticoid receptor antagonist RU486. Steroids 110-117 interleukin 10 Homo sapiens 130-135 9619632-0 1998 Modulation of ICAM-1, VCAM-1 and HLA-DR by cytokines and steroids on HUVECs and human brain endothelial cells. Steroids 57-65 intercellular adhesion molecule 1 Homo sapiens 14-20 9564825-5 1998 StAR facilitates the efficient production of steroid hormone by regulating the translocation of cholesterol from the outer to the inner mitochondrial membrane, the site of the cytochrome P450 side-chain cleavage (P450scc) enzyme system that converts cholesterol to pregnenolone. Steroids 45-60 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 213-220 9528966-2 1998 In the rat hippocampus, the actions of adrenal steroids are mediated by two receptor types, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Steroids 47-55 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 96-119 9528966-2 1998 In the rat hippocampus, the actions of adrenal steroids are mediated by two receptor types, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Steroids 47-55 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 121-123 9543154-7 1998 These data suggest that IDBP is relatively specific for 25OHD3 and that additional hsp-70-like binding proteins are present in unpurified New World primate cell extracts that are specific for 1-hydroxylated vitamin D metabolites as well as other gonadal steroid hormones. Steroids 254-270 heat shock protein family A (Hsp70) member 4 Homo sapiens 83-89 9645963-1 1998 Activity-induced brain-derived neurotrophic factor (BDNF) expression is negatively modulated by circulating adrenal steroids. Steroids 116-124 brain-derived neurotrophic factor Rattus norvegicus 17-50 9645963-1 1998 Activity-induced brain-derived neurotrophic factor (BDNF) expression is negatively modulated by circulating adrenal steroids. Steroids 116-124 brain-derived neurotrophic factor Rattus norvegicus 52-56 9501181-4 1998 Adding FeSO4 to C6 cells increased the synthesis of both P and D. Even in the presence of aminoglutethimide, an inhibitor of P450scc, FeSO4 increased the synthesis of both steroids, indicating that the Fe2+-sensitive process does not involve P450scc. Steroids 172-180 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 125-132 9501181-4 1998 Adding FeSO4 to C6 cells increased the synthesis of both P and D. Even in the presence of aminoglutethimide, an inhibitor of P450scc, FeSO4 increased the synthesis of both steroids, indicating that the Fe2+-sensitive process does not involve P450scc. Steroids 172-180 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 242-249 9497372-4 1998 Indeed, supplying cells with steroid precursors revealed that TGF-beta1 inhibited two steps in the steroid synthesis pathway, one prior to pregnenolone production and another corresponding to P450c17. Steroids 29-36 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 192-199 9497372-4 1998 Indeed, supplying cells with steroid precursors revealed that TGF-beta1 inhibited two steps in the steroid synthesis pathway, one prior to pregnenolone production and another corresponding to P450c17. Steroids 99-106 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 192-199 9521675-2 1998 1.1.1.213, AKR1C9) is a member of the aldo-keto reductase (AKR) superfamily which inactivates circulating steroid hormones. Steroids 106-122 aldo-keto reductase family 1, member C14 Rattus norvegicus 11-17 9495812-1 1998 Rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating steroid hormones and may contribute to the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiols to reactive o-quinones with the concomitant generation of reactive oxygen species. Steroids 148-164 aldo-keto reductase family 1, member C14 Rattus norvegicus 59-69 9465106-1 1998 DHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Steroids 48-55 sulfotransferase family 2A member 1 Homo sapiens 20-25 7819459-6 1994 A simple method for extracting fecal steroid metabolites optimized extraction efficiencies of the E2 and P4 excretion products (90.1 +/- 0.8% and 87.2 +/- 1.4%, respectively). Steroids 37-44 prostaglandin E2 receptor EP4 subtype Felis catus 98-107 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Steroids 45-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 189-207 7947199-2 1994 It has been shown previously that the potent steroid hormone 1,25-dihydroxyvitamin D3 (1,25-D3) modulates growth and differentiation of keratinocytes via binding to a high-affinity nuclear vitamin D receptor (VDR). Steroids 45-60 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 209-212 7958897-1 1994 Steroidogenic factor 1 (SF-1), an orphan nuclear receptor, regulates the enzymes that produce sex steroids, and disruption of the Ftz-F1 gene encoding SF-1 precludes adrenal and gonadal development. Steroids 98-106 nuclear receptor subfamily 5, group A, member 1 Mus musculus 130-136 7934979-0 1994 Impact of suprapharmacological androgenic steroid administration on basal and insulin-stimulated glucose and amino acid metabolism. Steroids 42-49 insulin Canis lupus familiaris 78-85 7934979-10 1994 Glucose infusion rates were lower in the steroid group with 15 mU/kg.min immunoreactive insulin at 32 days (15.0 +/- 1.1 v 21.2 +/- 1.4 mU/kg.min). Steroids 41-48 insulin Canis lupus familiaris 88-95 7934979-11 1994 Immunoreactive insulin-independent glucose utilization (Rd) was unaffected at 18 days of steroid treatment, but was increased by almost fourfold at 32 days. Steroids 89-96 insulin Canis lupus familiaris 15-22 7982333-2 1994 These studies demonstrated that prenatal steroid treatment reduces RDS among premature newborns at 26 to 33 weeks gestation. Steroids 41-48 peripherin 2 Homo sapiens 67-70 7982333-5 1994 With PROM, mothers may have an increased risk of endometritis without a clear increase in overall frequency of infection, at the same time steroids significantly decrease the frequency of RDS in the newborns. Steroids 139-147 peripherin 2 Homo sapiens 188-191 7982333-6 1994 During these 22 years of evaluation and application of prenatal steroid treatment to reduce RDS, the survival of the very low birth weight (< 1501 g) newborn has increased dramatically. Steroids 64-71 peripherin 2 Homo sapiens 92-95 8046245-6 1994 This pattern of XDH/XO regulation by cytokines and steroids is analogous to the profile of response seen by acute phase reactants. Steroids 51-59 xanthine dehydrogenase Bos taurus 16-19 8039711-8 1994 To assess what impact these substitutions might have on the steroid-binding activity of RIIIS/J CBG, these mutations were introduced separately or together into a BALB/c mouse Cbg cDNA. Steroids 60-67 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 96-99 8039711-9 1994 Expression of these mutants in the MDCK cell line indicated that the Lys201-->Glu substitution accounts for the abnormal steroid-binding affinity of CBG in RIIIS/J mice. Steroids 124-131 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 152-155 7912043-6 1994 Since interleukin-1, tumor necrosis factor, and endotoxin are known to upregulate neutrophil CD11b surface expression and are released during CPB in humans, while steroids are known to suppress the release of these cytokines, the authors conclude that the blunting effect by steroids on CD11b surface expression upregulation during and after CPB in humans is attributed to suppressed cytokine release. Steroids 163-171 integrin subunit alpha M Homo sapiens 93-98 7912043-6 1994 Since interleukin-1, tumor necrosis factor, and endotoxin are known to upregulate neutrophil CD11b surface expression and are released during CPB in humans, while steroids are known to suppress the release of these cytokines, the authors conclude that the blunting effect by steroids on CD11b surface expression upregulation during and after CPB in humans is attributed to suppressed cytokine release. Steroids 163-171 integrin subunit alpha M Homo sapiens 287-292 7912043-6 1994 Since interleukin-1, tumor necrosis factor, and endotoxin are known to upregulate neutrophil CD11b surface expression and are released during CPB in humans, while steroids are known to suppress the release of these cytokines, the authors conclude that the blunting effect by steroids on CD11b surface expression upregulation during and after CPB in humans is attributed to suppressed cytokine release. Steroids 275-283 integrin subunit alpha M Homo sapiens 93-98 8195238-1 1994 A novel stereoselective hydroxysteroid sulfotransferase (HST) that acts on neutral steroids having the 3-hydroxyl group in the alpha orientation but not on steroids where the 3-hydroxyl group is oriented in the beta position has been cloned and expressed. Steroids 83-91 sulfotransferase family 2A member 1 Homo sapiens 57-60 8195238-1 1994 A novel stereoselective hydroxysteroid sulfotransferase (HST) that acts on neutral steroids having the 3-hydroxyl group in the alpha orientation but not on steroids where the 3-hydroxyl group is oriented in the beta position has been cloned and expressed. Steroids 156-164 sulfotransferase family 2A member 1 Homo sapiens 57-60 8195238-5 1994 The guinea pig HST cDNA transiently transfected into Chinese hamster ovary K1 cells expressed a protein identical in size to that of purified guinea pig HST specific for 3 alpha-hydroxylated neutral steroids that was recently reported (Driscoll, W. J., Martin, B. M., Chen, H.-C., and Strott, C. A. Steroids 199-207 sulfotransferase family 2A member 1 Homo sapiens 15-18 8195238-5 1994 The guinea pig HST cDNA transiently transfected into Chinese hamster ovary K1 cells expressed a protein identical in size to that of purified guinea pig HST specific for 3 alpha-hydroxylated neutral steroids that was recently reported (Driscoll, W. J., Martin, B. M., Chen, H.-C., and Strott, C. A. Steroids 199-207 sulfotransferase family 2A member 1 Homo sapiens 153-156 8195238-9 1994 The expressed HST likewise exhibited sulfotransferase activity that was directed specifically toward steroid substrates containing a 3-hydroxyl group in the alpha orientation; on the other hand, steroids with a 3 beta-hydroxyl group were not sulfonated by the expressed HST. Steroids 101-108 sulfotransferase family 2A member 1 Homo sapiens 14-17 8195238-9 1994 The expressed HST likewise exhibited sulfotransferase activity that was directed specifically toward steroid substrates containing a 3-hydroxyl group in the alpha orientation; on the other hand, steroids with a 3 beta-hydroxyl group were not sulfonated by the expressed HST. Steroids 195-203 sulfotransferase family 2A member 1 Homo sapiens 14-17 8195238-10 1994 Thus, the cloned HST cDNA clearly coded for a steroid sulfotransferase with chiral specificity for 3 alpha-hydroxylated neutral steroids and was, therefore, given the designation of guinea pig 3 alpha-hydroxysteroid sulfotransferase (gp3 alpha-HST). Steroids 128-136 sulfotransferase family 2A member 1 Homo sapiens 17-20 7917778-5 1994 The aim of the present study was to determine whether cyclical alterations in beta 2-adrenoceptor expression, occurring under the influence of ovarian sex-steroid hormones, may offer an explanation for these findings. Steroids 155-162 adrenoceptor beta 2 Homo sapiens 78-97 7917778-10 1994 In females during the luteal phase, the increase in sex-steroid hormones was mirrored by an increase in lymphocyte beta 2-adrenoceptor density (Bmax) and in maximal cyclic AMP response to isoprenaline (Emax), which were significantly higher than in male subjects. Steroids 56-63 adrenoceptor beta 2 Homo sapiens 115-134 8046298-9 1994 Reduction (50-75%) of cholesterol side-chain cleavage enzyme (P450scc) mRNA expression was also noted with H-7 in ACTH-treated cultures after 6 and 24 h. In contrast, TPA doubled the corticosterone secretion induced by 8-Br cAMP, but did not further increase the ACTH-induced secretion after 24 h. TPA alone, however, was not able to induce steroid secretion or P450scc mRNA expression. Steroids 341-348 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 62-69 8158251-1 1994 The inhibition of Ca2+ channel currents by endogenous brain steroids was examined in freshly dissociated pyramidal neurons from the adult guinea pig hippocampal CA1 region. Steroids 60-68 LOW QUALITY PROTEIN: carbonic anhydrase 2 Cavia porcellus 18-21 8180104-2 1994 We previously reported that activated glucocorticoid receptor-steroid complexes from rat HTC cell cytosol exist as at least two sub-populations, one of which requires a low molecular weight (700-3000 Da) factor(s) for binding to DNA. Steroids 62-69 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 38-61 8126139-13 1994 In children with CPP, the withdrawal of gonadal steroids may inhibit the child"s ability to secrete the GH appropriate for his/her GH/GHBP milieu. Steroids 48-56 growth hormone receptor Homo sapiens 134-138 8142314-1 1994 The human cytosolic sulfotransferases (STs), dehydroepiandrosterone sulfotransferase (DHEA-ST) and the phenol-sulfating form of phenol sulfotransferase, (P-PST), have been expressed in bacteria and used to investigate the ability of the cloned enzymes to conjugate steroids and related compounds. Steroids 265-273 sulfotransferase family 2A member 1 Homo sapiens 45-84 8049525-8 1994 Together, these results implicate an androgen-regulated autocrine loop composed of amphiregulin and its receptor in prostate cancer cell growth and suggest that the mechanism of steroid hormone regulation of amphiregulin synthesis may occur through androgen upregulation of the EGF-R and subsequent receptor-dependent pathways. Steroids 178-193 amphiregulin Homo sapiens 83-95 8049525-8 1994 Together, these results implicate an androgen-regulated autocrine loop composed of amphiregulin and its receptor in prostate cancer cell growth and suggest that the mechanism of steroid hormone regulation of amphiregulin synthesis may occur through androgen upregulation of the EGF-R and subsequent receptor-dependent pathways. Steroids 178-193 amphiregulin Homo sapiens 208-220 8061932-5 1994 We found that CRABP II protein and mRNA were strongly increased upon retinoic acid application: this induction was significantly inhibited by concomitant application of triamcinolone acetonide; a more potent steroid, difluocortolone valerate, was also found to diminish normal endogenous expression of CRABP II. Steroids 208-215 cellular retinoic acid binding protein 2 Homo sapiens 14-22 7510997-4 1994 Immunopurification from cytosol of [3H]steroid-labeled tungstate-stabilized PR with anti-PR immunoadsorbent yielded "9S"-PR species in which hsp90, hsp70 and p59/HBI were present. Steroids 39-46 heat shock protein family A (Hsp70) member 4 Homo sapiens 148-153 7510997-4 1994 Immunopurification from cytosol of [3H]steroid-labeled tungstate-stabilized PR with anti-PR immunoadsorbent yielded "9S"-PR species in which hsp90, hsp70 and p59/HBI were present. Steroids 39-46 HLA complex P5B Homo sapiens 158-161 8109444-8 1994 The alterations in the proteins/glycoproteins and elastin produced by DEX observed in organ-cultured HTM may play a role in the reduction in aqueous outflow facility observed clinically in steroid glaucoma. Steroids 189-196 elastin Homo sapiens 50-57 8140596-6 1994 Cross-reactivity data from related steroids suggested only a small contribution to the DHEAS titer by other steroids. Steroids 35-43 sulfotransferase family 2A member 1 Homo sapiens 87-92 8140596-6 1994 Cross-reactivity data from related steroids suggested only a small contribution to the DHEAS titer by other steroids. Steroids 108-116 sulfotransferase family 2A member 1 Homo sapiens 87-92 19912962-3 1993 Previous studies have indicated that in the hippocampus adrenal steroids negatively regulate the expression of the mRNAs encoding the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), and the growth-associated protein GAP-43, while the preproenkephalin (ppENK) mRNA is positively regulated by glucocorticoids. Steroids 64-72 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 134-157 19912962-3 1993 Previous studies have indicated that in the hippocampus adrenal steroids negatively regulate the expression of the mRNAs encoding the glucocorticoid receptor (GR), the mineralocorticoid receptor (MR), and the growth-associated protein GAP-43, while the preproenkephalin (ppENK) mRNA is positively regulated by glucocorticoids. Steroids 64-72 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 159-161 8115018-0 1993 Dopamine and sex steroid regulation of POMC gene expression in the hypothalamus. Steroids 17-24 proopiomelanocortin Rattus norvegicus 39-43 8115018-1 1993 Previous studies have shown that POMC mRNA and peptide levels are increased in the medial basal hypothalamus (MBH) of the chronically castrated rat and are suppressed with sex steroid replacement. Steroids 176-183 proopiomelanocortin Rattus norvegicus 33-37 8306635-8 1993 Higher levels of GnRH receptor mRNA were found in the pituitaries of steers than in cohort bulls, suggesting regulation of GnRH receptor gene expression by testicular steroids. Steroids 167-175 gonadotropin releasing hormone receptor Bos taurus 17-30 8306635-8 1993 Higher levels of GnRH receptor mRNA were found in the pituitaries of steers than in cohort bulls, suggesting regulation of GnRH receptor gene expression by testicular steroids. Steroids 167-175 gonadotropin releasing hormone receptor Bos taurus 123-136 8396146-6 1993 Further analyses using synthetic oligonucleotides revealed that vitamin D receptor DNA binding domain could discriminate the spacing number between the consensus steroid-responsible element motif and had different affinities to direct repeats that consisted of various related sequences. Steroids 162-169 vitamin D receptor Homo sapiens 64-82 8399852-1 1993 The synthetic steroid 7 alpha-methyl-19-nortestosterone (MENT) binds with high affinity to the androgen receptor and exerts biological effects at some peripheral target tissues with a potency greater than that of naturally occurring androgens. Steroids 14-21 androgen receptor Rattus norvegicus 95-112 8255389-2 1993 Presently, we found that bromocriptine (BROM) treatment increased the levels of GCR in DES-T, demonstrated by steroid binding assays and immunocytochemistry using a monoclonal antibody against the type II GCR. Steroids 110-117 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 80-83 8255389-8 1993 In this respect, inefficient steroid negative feedback on PRL synthesis due to down-regulation of GCR may contribute to hyperprolactinemia. Steroids 29-36 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 98-101 8348267-6 1993 Our study confirms that there was significant increase in the absolute number of CD8+ T cells during steroid treatment in the PMR/GCA patients, but indicates the persistence of an immunological alteration despite the control of disease manifestations. Steroids 101-108 CD8a molecule Homo sapiens 81-84 8352545-2 1993 In particular, we discuss the antitumor activity of the esters of homo-aza steroids in which the p-N,N-bis(2-chloroethyl)aminophenoxyacetic acid is linked to the C-3 or C-17 position, while the lactam nucleus is linked to the D or A ring of the modified steroid respectively. Steroids 75-82 complement C3 Homo sapiens 162-165 8514758-0 1993 A complex array of double-stranded and single-stranded DNA-binding proteins mediates induction of the ovalbumin gene by steroid hormones. Steroids 120-136 ovalbumin (SERPINB14) Gallus gallus 102-111 8514758-1 1993 The transcriptional induction of the chicken ovalbumin gene by steroid hormones is abolished by inhibitors of protein synthesis such as cycloheximide, suggesting that a labile protein mediates this process. Steroids 63-79 ovalbumin (SERPINB14) Gallus gallus 45-54 8477648-1 1993 The enzyme 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-Isomerase (3 beta HSD) catalyzes the conversion of delta 5-3 beta-hydroxysteroids to delta 4-3-ketosteroids, an essential step in the biosynthesis of all biologically active steroid hormones. Steroids 237-253 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 74-84 8473901-0 1993 Complex interactions among second messenger pathways, steroid hormones, and protooncogenes of the Fos and Jun families converge in the regulation of the nerve growth factor gene. Steroids 54-61 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 98-101 9468515-1 1998 Regulation of the human CYP11A gene encoding cytochrome P450scc, which catalyzes the first step of steroid synthesis, is regulated by many trans-acting transcription factors including steroidogenic factor 1 (SF-1). Steroids 99-106 splicing factor 1 Homo sapiens 184-212 9473366-0 1998 Effects of gonadectomy and steroids on plasma and pituitary levels of somatolactin in Atlantic salmon, Salmo salar. Steroids 27-35 somatolactin Salmo salar 70-82 9442036-0 1998 Glucocorticoids stimulate p21 gene expression by targeting multiple transcriptional elements within a steroid responsive region of the p21waf1/cip1 promoter in rat hepatoma cells. Steroids 102-109 KRAS proto-oncogene, GTPase Rattus norvegicus 26-29 9442037-9 1998 Our results have established a functional link between the glucocorticoid receptor signaling pathway that mediates a G1 cell cycle arrest of rat hepatoma cells and the transcriptional control of p21 by a cascade that requires the steroid induction of C/EBP alpha gene expression. Steroids 230-237 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 59-82 33071817-9 2020 These are the first in vivo data showing that our novel lipid raft disruptor carboxamido-steroid compound exerts antinociceptive and antihyperalgesic effects by inhibiting TRPV1 and TRPA1 ion channel activation similarly to MCD, but in 150-fold lower concentrations. Steroids 89-96 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 182-187 9442037-9 1998 Our results have established a functional link between the glucocorticoid receptor signaling pathway that mediates a G1 cell cycle arrest of rat hepatoma cells and the transcriptional control of p21 by a cascade that requires the steroid induction of C/EBP alpha gene expression. Steroids 230-237 KRAS proto-oncogene, GTPase Rattus norvegicus 195-198 9704146-6 1998 The clinical effectiveness of anti-TNF-alpha antibodies and of IL-10 has been demonstrated in steroid-refractory Crohn"s disease patients. Steroids 94-101 interleukin 10 Homo sapiens 63-68 8486361-1 1993 The biosynthesis of steroid hormones in the gonads and adrenal glands requires the activities of the enzyme 3 beta-hydroxysteroid dehydrogenase/isomerase (3 beta HSD) which catalyzes the NAD(+)-dependent dehydrogenation and subsequent delta 5-->delta 4 isomerization of delta 5-3 beta-hydroxysteroids to delta 4-3-ketosteroids. Steroids 20-27 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 155-165 19912921-14 1993 These results indicate that GR and MR mRNAs exhibit hippocampus-specific diurnal rhythms in expression which are controlled to a greater (MR) or lesser (GR) extent by circulating steroids. Steroids 179-187 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 28-30 19912921-14 1993 These results indicate that GR and MR mRNAs exhibit hippocampus-specific diurnal rhythms in expression which are controlled to a greater (MR) or lesser (GR) extent by circulating steroids. Steroids 179-187 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 153-155 32520725-9 2020 One patient harbouring a CCDC141 RSV showed a reversal of CHH after sex steroid replacement. Steroids 72-79 coiled-coil domain containing 141 Homo sapiens 25-32 8484674-2 1993 Compared with 518 postmenopausal control women (aged 45-65 years), DHEAS levels were below normal in the 120 patients with RA who had never taken corticosteroids and levels were further depressed in 39 patients currently using steroids. Steroids 153-161 sulfotransferase family 2A member 1 Homo sapiens 67-72 8484674-3 1993 Twenty six patients who had completed steroid treatment also had lower DHEAS levels, suggesting a delayed recovery of adrenal androgen secretion. Steroids 38-45 sulfotransferase family 2A member 1 Homo sapiens 71-76 8461255-7 1993 These data strongly suggest that compounds bearing bulky substituents on the steroid A and/or C rings, like deacylcortivazol and RU486, are positioned differently from canonical glucocorticoids in the steroid binding groove of the GR. Steroids 77-84 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 231-233 8461255-7 1993 These data strongly suggest that compounds bearing bulky substituents on the steroid A and/or C rings, like deacylcortivazol and RU486, are positioned differently from canonical glucocorticoids in the steroid binding groove of the GR. Steroids 201-208 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 231-233 9580500-8 1998 CONCLUSION: Cord 17 alpha-OHP concentrations were very high as previously described, probably owing to steroid production by fetal adrenal glands. Steroids 103-110 Cone-rod dystrophy 17 Homo sapiens 12-19 32832524-3 2020 Objectives: To determine whether steroid-naive children are at higher risk of PICU admission among those hospitalised for SAA. Steroids 33-40 serum amyloid A1 cluster Homo sapiens 122-125 9501292-6 1998 Steroidogenic factor-1 is highly expressed in steroid-producing tissues and in gonadotrophs and plays a pivotal role in regulating the expression of enzymes and hormones essential for steroid biosynthesis pathways. Steroids 46-53 nuclear receptor subfamily 5, group A, member 1 Mus musculus 0-22 9501292-6 1998 Steroidogenic factor-1 is highly expressed in steroid-producing tissues and in gonadotrophs and plays a pivotal role in regulating the expression of enzymes and hormones essential for steroid biosynthesis pathways. Steroids 184-191 nuclear receptor subfamily 5, group A, member 1 Mus musculus 0-22 9428795-2 1997 This effect is mediated by the so-called Steroid Responsive Unit (SRU) of the AGP promoter that contains several binding sites for C/EBP transcription factors, some of which overlap with the Glucocorticoid Responsive Element (GRE). Steroids 41-48 orosomucoid 1 Rattus norvegicus 78-81 8387158-13 1993 These data provide strong evidence for the regulation of the 3 beta HSD-I and 17 beta HSD-II genes by cAMP and PKC and, thus, indicate an important endocrine and/or paracrine regulation of steroid hormone production in human placenta. Steroids 189-204 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 61-73 8381969-8 1993 Mutational analysis of the steroid hormone binding domain and the overlapping AP-1 site at the VDRE supports mutually exclusive occupancy by Fos-Jun heterodimers and vitamin D receptor. Steroids 27-42 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 141-144 7678259-5 1993 To test if the steroid modulates the osteoclast integrin alpha v beta 3 (the vitronectin receptor), we examined the effects of 1,25-(OH)2D3 on transcription of the alpha v gene as well as surface expression and function of alpha v beta 3, in chicken osteoclast precursors. Steroids 15-22 vitronectin Gallus gallus 77-88 9328296-3 1997 These steroid chemicals also inhibited CYP2C9-dependent S-warfarin 7-hydroxylation activities though lesser extents seen with those in CYP2C19 enzyme. Steroids 6-13 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 135-142 32556218-0 2020 Steroids Regulate SLC2A1 and SLC2A3 to Deliver Glucose Into Trophectoderm for Metabolism via Glycolysis. Steroids 0-8 solute carrier family 2, facilitated glucose transporter member 3 Sus scrofa 29-35 7678732-1 1993 Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3"-phosphoadenosine 5"-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. Steroids 146-154 sulfotransferase family 2A member 1 Homo sapiens 0-40 7678732-1 1993 Dehydroepiandrosterone sulphotransferase (DHEA-ST) catalyses the 3"-phosphoadenosine 5"-phosphosulphate-dependent sulphation of a wide variety of steroids in human liver and adrenal tissue and is responsible for most, if not all, of the sulphation of bile acids in human liver. Steroids 146-154 sulfotransferase family 2A member 1 Homo sapiens 42-49 9301744-9 1997 Steroid-responsive tremor syndrome had developed in 22 of 24 dogs, half of which had abnormal results of CSF analyses. Steroids 0-7 colony stimulating factor 2 Canis lupus familiaris 105-108 32180118-0 2020 Ruxolitinib treatment of a patient with steroid-dependent severe autoimmunity due to STAT1 gain-of-function mutation. Steroids 40-47 signal transducer and activator of transcription 1 Homo sapiens 85-90 9275211-1 1997 Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). Steroids 21-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 107-125 8406338-5 1993 Our data agree with the hypothesis that the pubertal spurt is mediated by a sex-steroid-induced rise in GH concentration, and they suggest that the levels of GHBP may be related to the GH secretion and its variation with treatment. Steroids 80-87 growth hormone receptor Homo sapiens 158-162 9275211-1 1997 Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts its actions through the vitamin D receptor (VDR). Steroids 21-36 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 127-130 32422398-12 2020 Third, Kiss1 neurons of the arcuate nucleus are responsive to both TH and E2, which places them at the crossroads of photoperiodic transduction pathway and sex steroid feedback. Steroids 160-167 metastasis-suppressor KiSS-1 Ovis aries 7-12 9349751-5 1997 mCCCP severely inhibited CRH-stimulated steroid production in both cell types, indicating that an electrochemical gradient across the inner mitochondrial membrane is required for CRH-stimulated steroidogenesis. Steroids 40-47 corticotropin releasing hormone Mus musculus 25-28 8009069-4 1993 CD8 cells monitoring may be useful in order to decide withdrawing steroids. Steroids 66-74 CD8a molecule Homo sapiens 0-3 32247663-1 2020 Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells. Steroids 122-129 solute carrier family 51 subunit alpha Homo sapiens 0-37 1438252-1 1992 Embryonic nuclear proteins from the sea urchin Strongylocentrotus purpuratus bind in vitro to a cis-acting element that lies upstream of the actin gene CyIIIb and consists of two direct repeats homologous to steroid hormone response elements. Steroids 208-223 actin-15B Strongylocentrotus purpuratus 100-105 1425409-2 1992 In female rats, a steroid-induced LH surge is accompanied by an increase in FOS-positive GnRH neurons, especially in the region of the organum vasculosum of the lamina terminalis. Steroids 18-25 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 76-79 32247663-1 2020 Organic solute transporter alpha/beta (OSTalpha/beta) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells. Steroids 122-129 solute carrier family 51 subunit alpha Homo sapiens 39-52 9307068-4 1997 Furthermore, the steroid inhibited leukocyte emigration, but not adhesion, caused by superfusion of the mesenteric vascular bed with PAF. Steroids 17-24 PCNA clamp associated factor Rattus norvegicus 133-136 32328699-1 2020 We previously demonstrated the existence of a balance among steroid hormones, i.e. glucocorticoids and androgens, in RACK1 (receptor for activated C kinase 1) expression and innate immunity activation, which may offer the opportunity to use RACK1 expression as marker to evaluate immunotoxicity of hormone-active substances. Steroids 60-67 receptor for activated C kinase 1 Homo sapiens 117-122 9261164-8 1997 In addition, we found that the steroid analog ZK98299 known to induce GR transrepression of AP-1 had no inhibitory effect on RelA activity. Steroids 31-38 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 70-72 9237999-2 1997 The C terminus of MLN64 shares significant homology with the steroidogenic acute regulatory protein (StAR), which plays a key role in steroid hormone biosynthesis by enhancing the intramitochondrial translocation of cholesterol to the cholesterol side-chain cleavage enzyme. Steroids 134-149 StAR related lipid transfer domain containing 3 Homo sapiens 18-23 1385468-9 1992 These data show that IGFBP-3, IGFBP-2, IGFBP-1, and presumably IGFBP-4 and its glycosylated form are differentially regulated by peptide and steroid hormones in endometrial stromal cells and that their regulation is a function of stromal differentiation. Steroids 141-148 insulin like growth factor binding protein 4 Homo sapiens 63-70 1424568-0 1992 Comparison of sex steroid hormone-dependent induction of chick oviduct delta-aminolaevulinic acid dehydratase during primary and secondary stimulation. Steroids 18-33 aminolevulinate dehydratase Gallus gallus 71-109 9237999-7 1997 MLN64 mRNA was found in many human tissues, including the placenta and brain, which synthesize steroid hormones but do not express StAR. Steroids 95-111 StAR related lipid transfer domain containing 3 Homo sapiens 0-5 32328699-1 2020 We previously demonstrated the existence of a balance among steroid hormones, i.e. glucocorticoids and androgens, in RACK1 (receptor for activated C kinase 1) expression and innate immunity activation, which may offer the opportunity to use RACK1 expression as marker to evaluate immunotoxicity of hormone-active substances. Steroids 60-67 receptor for activated C kinase 1 Homo sapiens 124-157 1283354-8 1992 The suppression of hmg1 and the enhancement of hmg2 and hmg3 transcript levels following elicitor treatment or inoculation with the incompatible race parallel the suppression in steroid and stimulation of sesquiterpenoid accumulations observed in earlier investigations. Steroids 178-185 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 Solanum tuberosum 47-51 32328699-1 2020 We previously demonstrated the existence of a balance among steroid hormones, i.e. glucocorticoids and androgens, in RACK1 (receptor for activated C kinase 1) expression and innate immunity activation, which may offer the opportunity to use RACK1 expression as marker to evaluate immunotoxicity of hormone-active substances. Steroids 60-67 receptor for activated C kinase 1 Homo sapiens 241-246 32328699-6 2020 Altogether, our data suggest that RACK1 may represent an interesting target of steroid-active compounds, and its evaluation may offer the opportunity to screen the immunotoxic potential of hormone-active substances. Steroids 79-86 receptor for activated C kinase 1 Homo sapiens 34-39 9230722-8 1997 Lymphocyte beta 2-AR density (log Bmax; fmol/10(6) cells) showed significant upregulation 3 h after steroid (FM+5 versus FM): 0.34 versus 0.24 (95% CI: 0.02 to 0.18; p = 0.01). Steroids 100-107 adrenoceptor beta 2 Homo sapiens 11-20 32455880-1 2020 The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. Steroids 145-152 ubiquitin protein ligase E3A Mus musculus 4-9 9183230-8 1997 By stepwise multiple regression, higher bronchodilator-inhaled steroid prescription ratios and lower inhaled steroid prescription rates were each significantly associated with ZIP codes in which greater proportions of residents lacked a high school diploma (P < .001); associations that approached statistical significance were found for higher bronchodilator-inhaled steroid ratios and fewer asthma care providers (P = .05) and for lower inhaled steroid prescription rates and lower proportions of asthma specialists (P = .04). Steroids 63-70 death associated protein kinase 3 Homo sapiens 176-179 9183230-8 1997 By stepwise multiple regression, higher bronchodilator-inhaled steroid prescription ratios and lower inhaled steroid prescription rates were each significantly associated with ZIP codes in which greater proportions of residents lacked a high school diploma (P < .001); associations that approached statistical significance were found for higher bronchodilator-inhaled steroid ratios and fewer asthma care providers (P = .05) and for lower inhaled steroid prescription rates and lower proportions of asthma specialists (P = .04). Steroids 109-116 death associated protein kinase 3 Homo sapiens 176-179 9183230-8 1997 By stepwise multiple regression, higher bronchodilator-inhaled steroid prescription ratios and lower inhaled steroid prescription rates were each significantly associated with ZIP codes in which greater proportions of residents lacked a high school diploma (P < .001); associations that approached statistical significance were found for higher bronchodilator-inhaled steroid ratios and fewer asthma care providers (P = .05) and for lower inhaled steroid prescription rates and lower proportions of asthma specialists (P = .04). Steroids 109-116 death associated protein kinase 3 Homo sapiens 176-179 9183230-8 1997 By stepwise multiple regression, higher bronchodilator-inhaled steroid prescription ratios and lower inhaled steroid prescription rates were each significantly associated with ZIP codes in which greater proportions of residents lacked a high school diploma (P < .001); associations that approached statistical significance were found for higher bronchodilator-inhaled steroid ratios and fewer asthma care providers (P = .05) and for lower inhaled steroid prescription rates and lower proportions of asthma specialists (P = .04). Steroids 109-116 death associated protein kinase 3 Homo sapiens 176-179 1331668-2 1992 Since we had already shown that sex steroids could induce a decrease in POMC mRNA levels in the arcuate nucleus of castrated rats, the involvement of the dopaminergic system in the inhibitory effect of estradiol (E2) was also investigated. Steroids 36-44 proopiomelanocortin Rattus norvegicus 72-76 1381375-2 1992 3 beta-Hydroxy-5-ene-steroid dehydrogenase/delta 5----delta 4-isomerase (3 beta HSD) catalyzes an obligatory step in the biosynthesis of steroid hormones. Steroids 137-153 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 73-83 9160706-8 1997 These results demonstrate that the Hoxa-11 gene is required for normal uterine stromal cell and glandular differentiation during pregnancy, as is the presence of the steroid-induced glandular LIF burst initiating embryo implantation. Steroids 166-173 homeobox A11 Mus musculus 35-42 32171179-15 2020 Apparently, sex steroid hormones display a significant gender- and species-specific role in the regulation of CYP2D. Steroids 16-23 cytochrome P450, 2d region Mus musculus 110-115 1381375-9 1992 These observations demonstrate that the localization of 3 beta HSD immunoreactivity and, therefore, the presumed sites of delta 5- to delta 4-steroid interconversion throughout gestation are principally the syncytiotrophoblast and intermediate trophoblast cells in placenta and the trophoblast cells in chorion and decidua in fetal membranes. Steroids 142-149 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 56-66 31049814-1 2020 BACKGROUND: Tacrolimus, a calcineurin inhibitor, is recommended by the recent guidelines from the Kidney Disease Improving Global Outcomes Group as the first-line treatment for steroid-resistant nephrotic syndrome (SRNS), but its clinical application in China is still limited. Steroids 177-184 calcineurin binding protein 1 Homo sapiens 26-47 1525044-4 1992 The role of different steroids in the regulation of P450 cholesterol side-chain cleavage enzyme (P450scc) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) was evaluated by measuring the conversion of P4 derived from unlabelled 25-hydroxycholesterol and from labelled pregnenolone, respectively. Steroids 22-30 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 147-157 9179426-0 1997 The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma. Steroids 72-79 ribonuclease A family member 3 Homo sapiens 17-44 9179426-0 1997 The use of serum eosinophil cationic protein (ECP) in the management of steroid therapy in chronic asthma. Steroids 72-79 ribonuclease A family member 3 Homo sapiens 46-49 32051346-1 2020 IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is a hallmark of severe asthma and chronic obstructive pulmonary disease (COPD). Steroids 52-59 interleukin 17A Homo sapiens 0-6 9179426-5 1997 OBJECTIVE: To investigate the feasibility to guide steroid therapy on the basis of the level of serum ECP in patients with chronic asthma. Steroids 51-58 ribonuclease A family member 3 Homo sapiens 102-105 9179426-16 1997 CONCLUSION: From this observational study it is concluded that adjusting steroid therapy guided by serum ECP-level may be helpful in tailoring asthma treatment. Steroids 73-80 ribonuclease A family member 3 Homo sapiens 105-108 9141521-5 1997 This indicates that the regulatory mechanism of HSP70 expression during the menstrual cycle differs between the endometrial glandular cells and myometrial smooth muscle cells and may be correlated with the period of sex steroid-related functions of the respective cells. Steroids 220-227 heat shock protein family A (Hsp70) member 4 Homo sapiens 48-53 1511346-0 1992 c-fos expression in noradrenergic A2 neurons of the rat during the estrous cycle and after steroid hormone treatments. Steroids 91-106 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 32054098-5 2020 Our most important findings are the following: In the case of C. pneumoniae seropositive patients we detected pronounced spontaneous interleukin (IL)-10 secretion and, in the case of steroid-resistant patients, IL-10 secretion was at a significantly higher level as compared with in-sensitive patients (p < 0.01). Steroids 183-190 interleukin 10 Homo sapiens 211-216 1597467-1 1992 The involvement of a vicinally spaced dithiol group in steroid binding to the glucocorticoid receptor has been deduced from experiments with the thiol-specific reagent methyl methanethiolsulfonate and the vicinal dithiol-specific reagent sodium arsenite. Steroids 55-62 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 78-101 1376410-9 1992 A binding motif is present in the PSA and hGK-1 promoters, closely resembling the consensus sequence for steroid-responsive elements. Steroids 105-112 kallikrein related peptidase 2 Homo sapiens 42-47 9106558-4 1997 In this study, we were interested to see how exogenous female sex-steroid hormones altered beta2-AR regulation in female asthmatics during the follicular phase, when endogenous hormone levels are normally low. Steroids 66-73 adrenoceptor beta 2 Homo sapiens 91-99 32054098-6 2020 Furthermore, steroid-resistant seropositive patients produced a significantly higher level of IL-10 spontaneously and under antigen stimulation as compared with steroid-resistant seronegative individuals (p < 0.05). Steroids 13-20 interleukin 10 Homo sapiens 94-99 9106445-11 1997 Finally, we show that glucocorticoids, stress-sensitive steroid hormones which are known to exacerbate the toxicity in kainic acid in CA3 neurons, exacerbate the metabolic effects of this excitotoxin as well; in this case, the steroid manipulation was carried out in rats prior to killing. Steroids 56-72 carbonic anhydrase 3 Rattus norvegicus 134-137 9106445-11 1997 Finally, we show that glucocorticoids, stress-sensitive steroid hormones which are known to exacerbate the toxicity in kainic acid in CA3 neurons, exacerbate the metabolic effects of this excitotoxin as well; in this case, the steroid manipulation was carried out in rats prior to killing. Steroids 56-63 carbonic anhydrase 3 Rattus norvegicus 134-137 1310618-1 1992 Modulators are proposed to be novel ether aminophosphoglycerides that stabilize unoccupied and occupied glucocorticoid receptor steroid binding and inhibit glucocorticoid receptor complex activation. Steroids 128-135 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 104-127 32054098-8 2020 In the steroid-resistant patients" sera, a remarkably high MMP-9 concentration was associated with C. pneumoniae seronegativity. Steroids 7-14 matrix metallopeptidase 9 Homo sapiens 59-64 1310618-1 1992 Modulators are proposed to be novel ether aminophosphoglycerides that stabilize unoccupied and occupied glucocorticoid receptor steroid binding and inhibit glucocorticoid receptor complex activation. Steroids 128-135 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 156-179 31686530-2 2020 In breast cancer cells, we recently identified the monomeric heme-globin neuroglobin (NGB) as part of a new mechanism induced by the steroid hormone 17beta-estradiol (E2) against oxidative stress. Steroids 133-140 neuroglobin Homo sapiens 73-84 9013574-1 1997 An important focus of structure-function studies of synthetic ligands for the vitamin D receptor (VDR) concerns the chiral center at carbon 20 of the steroid side chain; 20-epi analogues are 100-10, 000 times more potent transcriptionally than the natural hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3). Steroids 150-157 vitamin D receptor Homo sapiens 78-96 9013574-1 1997 An important focus of structure-function studies of synthetic ligands for the vitamin D receptor (VDR) concerns the chiral center at carbon 20 of the steroid side chain; 20-epi analogues are 100-10, 000 times more potent transcriptionally than the natural hormone 1alpha,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3). Steroids 150-157 vitamin D receptor Homo sapiens 98-101 1573678-1 1992 The potential effect of different classes of steroids on the expression of acetylcholine receptors (AChR) was studied in different primary cultures of newborn-rat skeletal muscle cells. Steroids 45-53 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 75-98 1573678-1 1992 The potential effect of different classes of steroids on the expression of acetylcholine receptors (AChR) was studied in different primary cultures of newborn-rat skeletal muscle cells. Steroids 45-53 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 100-104 31686530-2 2020 In breast cancer cells, we recently identified the monomeric heme-globin neuroglobin (NGB) as part of a new mechanism induced by the steroid hormone 17beta-estradiol (E2) against oxidative stress. Steroids 133-140 neuroglobin Homo sapiens 86-89 31693487-1 2020 The cytochrome P450 side-chain cleavage enzyme, encoded by the CYP11A1 gene, catalyzes the first and rate-limiting step of steroid hormone biosynthesis. Steroids 123-130 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 63-70 19912844-9 1992 The relatively high percentage of pyknotic cells that were GR-immunoreactive suggests that adrenal steroids influence cell survival directly through GRs. Steroids 99-107 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 59-61 31626910-3 2020 However, the adrenal C11-oxy C19 steroid, 11beta-hydroxyandrostenedione (11OHA4), also contributes to the active androgen pool in the prostate microenvironment, and while it has been shown to impact castration resistant prostate cancer, the C11-oxy C19 steroids together with the C11-oxy C21 steroids have not been studied in BPH. Steroids 33-40 aldo-keto reductase family 1 member C4 Homo sapiens 21-24 9070250-6 1997 Dietary and hormonal studies were carried out to investigate the role of the retinoid X receptor in the regulation of SCD1 by type II steroid hormones. Steroids 134-150 stearoyl-Coenzyme A desaturase 1 Mus musculus 118-122 1532354-10 1992 Low blood and SF levels of sulpho-conjugated steroids, particularly DHEAS, are a permanent disorder in patients with RA and positive RF reactivity. Steroids 45-53 sulfotransferase family 2A member 1 Homo sapiens 68-73 31626910-3 2020 However, the adrenal C11-oxy C19 steroid, 11beta-hydroxyandrostenedione (11OHA4), also contributes to the active androgen pool in the prostate microenvironment, and while it has been shown to impact castration resistant prostate cancer, the C11-oxy C19 steroids together with the C11-oxy C21 steroids have not been studied in BPH. Steroids 33-40 aldo-keto reductase family 1 member C4 Homo sapiens 241-244 9124340-7 1997 These results suggest that the specific unidirectional brain-to-blood transport system for CRH is dependent on energy and calcium channels, involves microtubules, is independent of the P-glycoprotein transporter, and is acutely modulated by adrenal steroids, cytokines, and endogenous opiates. Steroids 249-257 corticotropin releasing hormone Mus musculus 91-94 31626910-3 2020 However, the adrenal C11-oxy C19 steroid, 11beta-hydroxyandrostenedione (11OHA4), also contributes to the active androgen pool in the prostate microenvironment, and while it has been shown to impact castration resistant prostate cancer, the C11-oxy C19 steroids together with the C11-oxy C21 steroids have not been studied in BPH. Steroids 33-40 aldo-keto reductase family 1 member C4 Homo sapiens 241-244 31626910-3 2020 However, the adrenal C11-oxy C19 steroid, 11beta-hydroxyandrostenedione (11OHA4), also contributes to the active androgen pool in the prostate microenvironment, and while it has been shown to impact castration resistant prostate cancer, the C11-oxy C19 steroids together with the C11-oxy C21 steroids have not been studied in BPH. Steroids 253-261 aldo-keto reductase family 1 member C4 Homo sapiens 21-24 31902928-5 2020 Regarding neutrophilic airway inflammation in steroid-resistant asthma, IL-17 derived from Th17 cells and IL-8 and tumor necrosis factor-alpha derived mainly from macrophages were reported to be involved in the pathogenesis. Steroids 46-53 interleukin 17A Homo sapiens 72-77 9024954-1 1997 Dehydroepiandrosterone (DHEA) and its sulfate, DHEA-S, are plentiful adrenal steroid hormones that decrease with aging and may have significant neuropsychiatric effects. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 47-53 1309345-11 1992 We conclude that in the frog adrenal gland, the stimulatory effect of AVT on steroid secretion is mediated through activation of receptors related to the mammalian V2 and/or OXT receptors, which are positively coupled to phosphoinositide-specific phospholipase C. Steroids 77-84 oxytocin/neurophysin I prepropeptide Homo sapiens 174-177 31885322-7 2020 This review focuses on these aspects of cyclin D1 pathophysiology, which may be crucial for targeted therapy.Abbreviations: aa, amino acid; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin D-binding myb-like protein; DSB, double-strand DNA break; DNA-PK, DNA-dependent protein kinase; ER, estrogen receptor; FASN, fatty acid synthase; GSK3beta, glycogen synthase-3beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; HK2, hexokinase 2; HNF4alpha, and hepatocyte nuclear factor 4alpha; HR, homologous recombination; IR, ionizing radiation; KIP, kinase inhibitory protein; MCL, mantle cell lymphoma; NHEJ, non-homologous end-joining; PCAF, p300/CREB binding-associated protein; PGC1alpha, PPARgamma co-activator 1alpha; PEST, proline-glutamic acid-serine-threonine, PK, pyruvate kinase; PPAR, peroxisome proliferator-activated receptor; RB1, retinoblastoma protein; ROS, reactive oxygen species; SRC, steroid receptor coactivator; STAT, signal transducer and activator of transcription; TGFbeta, transforming growth factor beta; UPS, ubiquitin-proteasome system; USP22, ubiquitin-specific peptidase 22; XPO1 (or CRM1) exportin 1. Steroids 1151-1158 cyclin D1 Mus musculus 40-49 1379363-6 1992 In comparison with wild-type rat androgen receptor in prostate, the receptor in LNCaP cells has altered affinity for a number of steroids or analogs such as progesterone (R5020), antiprogesterone (RU486), two antiandrogens (cyperoterone acetate and hydroxyflutamide), and an androgen metabolite (epitestosterone). Steroids 129-137 androgen receptor Rattus norvegicus 33-50 9187539-5 1997 In the present experiment, we determined if this steroid exposure alters peripheral OT secretion during a provocative stimulus to OT release, such as cholecystokinin (CCK). Steroids 49-56 cholecystokinin Rattus norvegicus 167-170 31704607-0 2020 C-12 vs C-3 substituted bile salts: An example of the effects of substituent position and orientation on the self-assembly of steroid surfactant isomers. Steroids 126-133 complement C3 Homo sapiens 8-11 21533369-8 1997 Our results demonstrate for the first time that BRCA1 is specifically up-regulated by a progestin, a steroid known to induce the differentiation of epithelial mammary cells. Steroids 101-108 BRCA1 DNA repair associated Homo sapiens 48-53 1461994-2 1992 GM-CSF synthesis is regulated primarily by the ovarian steroid hormone oestrogen, but is also subject to modulation by factors including a seminal component of seminal vesicle origin which stimulates a 20-fold increase in luminal fluid content at mating, and bacterial lipopolysaccharide (LPS) and the T-lymphocyte and natural killer (NK) cell product interferon-gamma (IFN gamma). Steroids 55-70 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-6 31536721-2 2020 Our previous research into single knockout of Pgrmc1 or Pgrmc2 suggests that Pgrmc1 and Pgrmc2 regulate membrane progestin receptor or steroid synthesis and therefore female fertility in zebrafish. Steroids 135-142 progesterone receptor membrane component 2 Danio rerio 56-62 1910217-0 1991 Soluble CD8, IL-2 receptor, and tumor necrosis factor-alpha levels in steroid-resistant acute graft-versus-host disease. Steroids 70-77 CD8a molecule Homo sapiens 8-11 8977383-3 1997 We recently demonstrated that steroids, in particular estradiol, are potent regulators of testicular N-cad messenger RNA (mRNA) levels in vivo. Steroids 30-38 cadherin 2 Mus musculus 101-106 9011578-3 1997 To explore the biological significance of this observation, we placed a cDNA encoding Gs alpha in an expression vector under the control of a steroid-inducible promoter and isolated colonies of stably transfected C2C12 myoblasts. Steroids 142-149 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 86-94 1714456-2 1991 3-alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an important multifunctional oxidoreductase capable of metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins. Steroids 136-152 aldo-keto reductase family 1, member C14 Rattus norvegicus 0-36 31536721-2 2020 Our previous research into single knockout of Pgrmc1 or Pgrmc2 suggests that Pgrmc1 and Pgrmc2 regulate membrane progestin receptor or steroid synthesis and therefore female fertility in zebrafish. Steroids 135-142 progesterone receptor membrane component 2 Danio rerio 88-94 1714456-2 1991 3-alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an important multifunctional oxidoreductase capable of metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins. Steroids 136-152 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-49 33601398-1 2020 OBJECTIVE: Vitamin D (Vit D), a steroid hormone, has been linked to cognitive impairment and dementia, such as Alz-heimer"s disease (AD). Steroids 32-39 vitrin Mus musculus 11-14 8981364-3 1997 A role for CSF-1 in reproduction was originally suggested by the sex steroid hormone-regulated uterine epithelial synthesis of CSF-1 and the expression of its receptor in trophoblast and decidual cells. Steroids 69-84 colony stimulating factor 1 (macrophage) Mus musculus 11-16 8981364-3 1997 A role for CSF-1 in reproduction was originally suggested by the sex steroid hormone-regulated uterine epithelial synthesis of CSF-1 and the expression of its receptor in trophoblast and decidual cells. Steroids 69-84 colony stimulating factor 1 (macrophage) Mus musculus 127-132 31865316-7 2020 Taxifolin competitively inhibited rat AKR1C9 against steroid dihydrotestosterone (DHT), and docking analysis revealed that taxifolin bound to the steroid binding site of rat AKR1C9 with similar free energy with the substrate DHT. Steroids 53-60 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-44 9029732-9 1997 The complexity of 3 beta-HSD expression through multiple signaling pathways acting on a multigene family of enzymes may contribute importantly to the diverse patterns and locations of steroid hormone biosynthesis. Steroids 184-199 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 18-28 32270742-12 2020 CONCLUSIONS: Steroid resistance in pro-inflammatory CD28nullCD8+ T and NKT-like cells is associated with decreased SIRT1 expression. Steroids 13-20 sirtuin 1 Homo sapiens 115-120 8971138-3 1996 Both EST and DHEA ST can catalyze the sulfonation of steroid compounds, including exogenously administered steroids such as ethinyl estradiol. Steroids 53-60 sulfotransferase family 2A member 1 Homo sapiens 13-20 1831194-1 1991 The membrane-bound enzyme 3 beta-hydroxysteroid dehydrogenase/delta 5 -delta 4 isomerase (3 beta-HSD) catalyzes the conversion of delta 5 -3 beta-hydroxysteroid precursors into delta 4-ketosteroids, thus representing an essential step in the biosynthesis of all classes of hormonal steroids. Steroids 189-197 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 90-100 8971138-3 1996 Both EST and DHEA ST can catalyze the sulfonation of steroid compounds, including exogenously administered steroids such as ethinyl estradiol. Steroids 107-115 sulfotransferase family 2A member 1 Homo sapiens 13-20 32444132-0 2020 Early Steroid Withdrawal Protocol With Basiliximab and Rituximab in ABO-Incompatible Kidney Transplant Recipients. Steroids 6-13 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 68-71 8954056-9 1996 3 beta HSD is the first steroid cell autoantigen defined at the molecular level to be associated with idiopathic POF occurring in the absence of other polyglandular diseases. Steroids 24-31 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 0-10 8961266-2 1996 DAX-1 has been proposed to play a role in steroidogenesis because it is highly expressed in adrenocortical and testicular Leydig cells and because loss-of-function mutations lead to low serum levels of steroid hormones. Steroids 202-218 nuclear receptor subfamily 0, group B, member 1 Rattus norvegicus 0-5 8961266-10 1996 Taken together, these data indicate that DAX-1 expression in Sertoli cells may influence the development of spermatogenic cells in response to steroid and pituitary hormones. Steroids 143-150 nuclear receptor subfamily 0, group B, member 1 Rattus norvegicus 41-46 1920455-1 1991 Drosophila melanogaster alcohol dehydrogenase is an example of convergent evolution: it is not related to the ADHs of other organisms, but to short-chain dehydrogenases, which until now have been found only in bacteria and in mammalian steroid hormone metabolism. Steroids 236-251 aldo-keto reductase family 1 member A1 Homo sapiens 24-45 31888628-0 2019 Effect of ovarian steroids on vascular endothelial growth factor a expression in bovine uterine endothelial cells during adenomyosis. Steroids 18-26 vascular endothelial growth factor A Bos taurus 30-66 2069958-6 1991 The murine progesterone receptor had complete identity for the DNA binding domain of human and rabbit progesterone receptors and 99% homology with the chicken progesterone receptor; for the steroid binding domain, it had 96% homology with human and rabbit progesterone receptors and 86% homology with chicken progesterone receptors. Steroids 190-197 progesterone receptor Mus musculus 11-32 8990078-6 1996 In contrast, central administration of the 400-ng dose of e-NOS AS and the 800-ng dose of b-NOS AS significantly attenuated the steroid-induced LH surge. Steroids 128-135 nitric oxide synthase 3 Rattus norvegicus 58-63 31861570-0 2019 Neonatal Exposure to Agonists and Antagonists of Sex Steroid Receptors Affects AMH and FSH Plasma Level and Their Receptors Expression in the Adult Pig Ovary. Steroids 53-60 muellerian-inhibiting factor Sus scrofa 79-82 8958270-9 1996 Soluble TNF-RII, sIL-2R-, and IL-10 levels were significantly elevated 3 days prior to or at the onset of acute steroid-resistant rejection (P < or = 0.01 versus steroid-sensitive rejection and on uneventful postoperative course). Steroids 112-119 interleukin 10 Homo sapiens 30-35 8939970-2 1996 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), a member of the aldoketoreductase superfamily, inactivates circulating steroid hormones using NAD(P)H as cofactor. Steroids 131-147 aldo-keto reductase family 1, member C14 Rattus norvegicus 10-45 8939970-2 1996 Rat liver 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), a member of the aldoketoreductase superfamily, inactivates circulating steroid hormones using NAD(P)H as cofactor. Steroids 131-147 aldo-keto reductase family 1, member C14 Rattus norvegicus 47-57 2059213-3 1991 In addition to dexamethasone, other anti-inflammatory steroids also increased 15-PGDH activity in the order of their glucocorticoid activity. Steroids 54-62 carbonyl reductase 1 Homo sapiens 78-85 31871676-0 2020 Leukemic phase of ALK-negative anaplastic large cell lymphoma in a patient who is on androgenic steroids: A case report. Steroids 96-104 ALK receptor tyrosine kinase Homo sapiens 18-21 1917679-1 1991 The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is involved in the biosynthesis of all classes of active steroids, including androgens. Steroids 158-166 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 89-99 8917605-1 1996 In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward approximately 20-10% of its value in young adults during the 8th and 9th decades. Steroids 123-130 sulfotransferase family 2A member 1 Homo sapiens 63-68 8917605-2 1996 The mechanism of action of DHEA and DHEAS is poorly known and may include partial transformation into sex steroids, increase of bioavailable insulin-like growth factor 1, and effects on neurotransmitter receptors. Steroids 106-114 sulfotransferase family 2A member 1 Homo sapiens 36-41 31731733-5 2019 All three steroid receptors analyzed by immunohistochemistry, namely, the estrogen receptor (ER), the progesterone receptor (PR), and the vitamin D receptor (VDR), showed a significantly positive influence on the course of the disease, but only for the unifocal breast tumor patients. Steroids 10-17 vitamin D receptor Homo sapiens 138-156 2039753-0 1991 The effects of various serine protease inhibitors on estrogen receptor steroid binding. Steroids 71-78 cell division cycle 34, ubiqiutin conjugating enzyme Rattus norvegicus 23-38 31731733-5 2019 All three steroid receptors analyzed by immunohistochemistry, namely, the estrogen receptor (ER), the progesterone receptor (PR), and the vitamin D receptor (VDR), showed a significantly positive influence on the course of the disease, but only for the unifocal breast tumor patients. Steroids 10-17 vitamin D receptor Homo sapiens 158-161 31729433-14 2019 Therefore, steroid therapy may be considered especially in anti-TPO positive SAT patients and patients with high-level acute phase reactants. Steroids 11-18 thyroid peroxidase Homo sapiens 64-67 2016304-2 1991 Expression of the mouse whey acidic protein (WAP) gene is specific to the mammary gland, is induced several thousand-fold during pregnancy, and is under the control of steroid and peptide hormones. Steroids 168-175 whey acidic protein Mus musculus 24-43 2016304-2 1991 Expression of the mouse whey acidic protein (WAP) gene is specific to the mammary gland, is induced several thousand-fold during pregnancy, and is under the control of steroid and peptide hormones. Steroids 168-175 whey acidic protein Mus musculus 45-48 8911698-5 1996 RESULTS: Oral steroid treatment (2 mg/kg/day), given at the onset of the asthma attack, resulted in significant reduction in the ECP and EPX levels in all the children. Steroids 14-21 ribonuclease A family member 3 Homo sapiens 129-132 8911698-10 1996 Serial monitoring of ECP and EPX levels was found to be of some use in predicting clinical outcome in certain steroid-dependent asthmatics (group C) but of no value in the mild asthmatics (group A). Steroids 110-117 ribonuclease A family member 3 Homo sapiens 21-24 1706350-9 1991 In the presence of E2 and progesterone, there was an enhancement in the amount of IGFBP-3 and a marked enhancement of IGFBP-2 in the conditioned media, suggesting sex steroid-dependence of IGFBP-2 and, to a lesser extent, IGFBP-3 protein synthesis. Steroids 167-174 cystatin 12, pseudogene Homo sapiens 19-38 31576875-8 2019 In addition, transcriptome analysis revealed that crocin-I was effective in mediating the amelioration of lipid metabolism, mainly in fatty acid metabolism and steroid biosynthesis in CORT-treated mice. Steroids 160-167 cortistatin Mus musculus 184-188 8828500-0 1996 Androgen receptor gene expression in rat granulosa cells: the role of follicle-stimulating hormone and steroid hormones. Steroids 103-119 androgen receptor Rattus norvegicus 0-17 31352176-2 2019 Cytochrome P450 lanosterol 14alpha-demethylase (CYP51) is a key enzyme in sterols and steroids biosynthesis that involved in folliculogenesis and oocyte maturation, which is regulated by follicle stimulating hormone (FSH). Steroids 86-94 cytochrome P450, family 51 Rattus norvegicus 0-46 8903507-3 1996 The focus of work in our laboratory has been on the effects of steroid hormones, especially glucocorticoids, on expression of genes regulated by the Ah receptor. Steroids 63-79 aryl hydrocarbon receptor Rattus norvegicus 149-160 8883941-1 1996 Nurr1 and NGFI-B are closely related orphan members of the steroid-thyroid hormone receptor family involved in immediate early responses to stimuli such as growth factors. Steroids 59-66 nuclear receptor subfamily 4 group A member 2 Homo sapiens 0-5 2025255-4 1991 Accumulation of sulfated glycoprotein-2 (SGP-2) mRNA, whose rate of expression has been associated to the processes of programmed cell death, preceded the appearance of DNA degradation, starting to increase as early as 30 min after steroid injection, and maintained higher than controls until 8 hrs; a different time course was shown by changes in the levels of beta-actin mRNA. Steroids 232-239 clusterin Rattus norvegicus 16-39 2025255-4 1991 Accumulation of sulfated glycoprotein-2 (SGP-2) mRNA, whose rate of expression has been associated to the processes of programmed cell death, preceded the appearance of DNA degradation, starting to increase as early as 30 min after steroid injection, and maintained higher than controls until 8 hrs; a different time course was shown by changes in the levels of beta-actin mRNA. Steroids 232-239 clusterin Rattus norvegicus 41-46 8938989-2 1996 In glucocorticoid-deprived animals, stress-induced decrease in the cytoplasmic steroid binding was followed by parallel increases in its nuclear binding and TAT activity, suggesting a stimulation of TAT gene transcription by the GR in the absence of the ligand. Steroids 79-86 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 229-231 31352176-2 2019 Cytochrome P450 lanosterol 14alpha-demethylase (CYP51) is a key enzyme in sterols and steroids biosynthesis that involved in folliculogenesis and oocyte maturation, which is regulated by follicle stimulating hormone (FSH). Steroids 86-94 cytochrome P450, family 51 Rattus norvegicus 48-53 31414163-7 2019 Finally, through codon optimization, knockout of genes for the side reactions related enzymes GCY1 and YPR1, and increasing copies of the P-450lun and CPRlun, we developed a recombinant S. cerevisiae biocatalyst based on the C. lunatus steroid 14alpha-hydroxylation system to produce 14alpha-hydroxysteroids. Steroids 236-243 trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 Saccharomyces cerevisiae S288C 103-107 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 128-135 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-5 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 128-135 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 7-11 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 128-135 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 17-22 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 205-213 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-5 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 205-213 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 7-11 8663352-3 1996 Pdr5p (Lem1/Sts1/Ydr1p), a yeast ATP-binding cassette transporter, selectively decreases the intracellular levels of particular steroid hormones, indicating that active processes can affect the passage of steroids across biological membranes. Steroids 205-213 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 17-22 8882298-7 1996 IGF-II receptor concentrations, after the different steroid treatments, were consistent with the steroid effect on milk synthesis. Steroids 52-59 insulin-like growth factor 2 Rattus norvegicus 0-6 8882298-7 1996 IGF-II receptor concentrations, after the different steroid treatments, were consistent with the steroid effect on milk synthesis. Steroids 97-104 insulin-like growth factor 2 Rattus norvegicus 0-6 1847589-2 1991 The staining was dramatically affected by subacute treatment with ovarian steroids: epithelial cells were predominantly positive in immature rabbits, whereas, in sex steroid-primed rabbits, ET-1 was mainly localized in the stromal compartment. Steroids 74-82 endothelin-1 Oryctolagus cuniculus 190-194 1717247-4 1991 Although the roles of expressions of SGP-2 and pSvr-1 genes in steroid hormone-dependent tissues remain unclear, their presence might become useful molecular markers of tissue involution not only in androgen-dependent rat tissues but also in glucocorticoid-dependent ones, and also provide excellent model systems for the study of negative regulation mechanism of gene expression by steroid hormones. Steroids 63-78 clusterin Rattus norvegicus 37-42 1717247-4 1991 Although the roles of expressions of SGP-2 and pSvr-1 genes in steroid hormone-dependent tissues remain unclear, their presence might become useful molecular markers of tissue involution not only in androgen-dependent rat tissues but also in glucocorticoid-dependent ones, and also provide excellent model systems for the study of negative regulation mechanism of gene expression by steroid hormones. Steroids 383-399 clusterin Rattus norvegicus 37-42 31574937-1 2019 The transcription factor NURR1 is a constitutively active orphan receptor belonging to the steroid hormone receptor class NR4A. Steroids 91-98 nuclear receptor subfamily 4 group A member 2 Homo sapiens 25-30 1704133-9 1991 The results support a role of the c-jun protooncogene as a regulatory gene in the cascade model for steroid action whereby steroids rapidly regulate the regulatory genes, which in turn regulate many other structural genes. Steroids 100-107 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 34-39 1704133-9 1991 The results support a role of the c-jun protooncogene as a regulatory gene in the cascade model for steroid action whereby steroids rapidly regulate the regulatory genes, which in turn regulate many other structural genes. Steroids 123-131 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 34-39 8793116-11 1996 The glucocorticoid effects on V1aR mRNA and binding, and the presence of putative active GREs in the promoter of the V1aR gene strongly implicate a role for adrenal steroids in the regulation of V1a receptor gene expression in glucocorticoid receptor and/or mineralocorticoid receptor expressing tissues. Steroids 165-173 arginine vasopressin receptor 1A Rattus norvegicus 117-121 31511552-9 2019 The colonic transcriptional profile in steroid treated mice showed significant upregulation of a small subset of T cell associated genes, in particular C/EBPbeta, CD4, IL7R and STAT5a. Steroids 39-46 CD4 antigen Mus musculus 163-166 8771476-1 1996 We studied the medium- to long-term results of steroid injection into the carpal tunnel of women with the carpal tunnel syndrome (CTS). Steroids 47-54 transthyretin Homo sapiens 130-133 1846564-2 1991 We were interested in determining whether human 1,25-dihydroxyvitamin D-3 receptor (hVDR) and glucocorticoid receptor (GR), members of the steroid/thyroid hormone receptor family, are heterologously regulated by other steroids and related hormones. Steroids 218-226 vitamin D receptor Homo sapiens 48-82 31175921-6 2019 Using the steroid substrates, 22R-hydroxycholesterol (for cytochrome P450 cholesterol side chain cleavage), pregnenolone (for 3beta-hydroxysteroid dehydrogenase 1), progesterone (for cytochrome P450 17alpha-hydroxylase/C17,C20-lyase), androstenedione (for 17beta-hydroxysteroid dehydrogenase 3), testosterone (for steroid 5alpha-reductase 1), and dihydrotestosterone (for 3alpha-hydroxysteroid dehydrogenase), it was demonstrated that DEX inhibited 22R-hydroxycholesterol, pregnenolone, progesterone, and testosterone-mediated 5alpha-androstanediol formation at 1.5 muM. Steroids 10-17 aldo-keto reductase family 1, member C14 Rattus norvegicus 372-407 1724125-5 1991 We have found that steroids, such as glucocorticoids, stimulate the translation of MBP and PLP mRNAs in cell-free systems and inhibit the translation of CNP mRNA. Steroids 19-27 proteolipid protein 1 Homo sapiens 91-94 1822400-8 1991 Separately initiated polypeptides containing the DNA-binding and the steroid-binding domains of the androgen receptor are produced in vitro by using strong internal translation initiation sites. Steroids 69-76 androgen receptor Mus musculus 100-117 8664346-7 1996 Steroid inhibitors of 3 alpha-HSD sensitized HL60 cells to inducers of differentiation in a manner similar to indomethacin. Steroids 0-7 aldo-keto reductase family 1 member C4 Homo sapiens 22-33 31164437-7 2019 Systemic corticosteroids, but not maintenance inhaled steroids resulted in improved symptom control and exacerbations concomitant with a reduction in functional ILC2s despite persistently elevated IL-17+ lymphoid cells. Steroids 16-24 interleukin 17A Homo sapiens 197-202 8998961-1 1996 Cytochrome P450c17 is a key steroidogenic enzyme for the production of sex steroids in gonadal tissue and for cortisol production in adrenal tissue. Steroids 75-83 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 11-18 8724298-5 1996 After adjustment for multiple comparisons, there was significant negative correlation between steroid dose and DHEAS (RRank = -0.426, p = 0.005), but with none of the soluble immune mediators. Steroids 94-101 sulfotransferase family 2A member 1 Homo sapiens 111-116 8600944-12 1996 The differential effects of DEX on the proliferation of high and low IL-2 producers in vitro may implicate a selective outgrowth of Th1-like T cells in vivo in patients treated with steroids. Steroids 182-190 negative elongation factor complex member C/D Homo sapiens 132-135 1900844-0 1991 Phenotype suppression: a postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP-1 sites in steroid responsive promoter elements of tissue-specific genes. Steroids 165-172 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 127-130 1653354-6 1991 Analysis of the DNA and/or mRNA from these cells has identified missense mutations in the DNA binding (zinc finger) domain and a nonsense mutation in the steroid binding domain of VDR. Steroids 154-161 vitamin D receptor Homo sapiens 180-183 31620295-1 2019 Background: Dehydroepiandrosterone sulfate (DHEAS) is an endogenous steroid hormone produced by the adrenal gland. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 44-49 1958544-1 1991 Steroid 17 alpha-hydroxylase has emerged as a key enzyme in steroidogenic cells: (i) it represents the branch point between the 17-deoxy (mineralo) and the 17-hydroxy (gluco) corticosteroid pathways in the adrenal cortex; (ii) the corresponding specific cytochrome (P-450(17 alpha] is highly dependent upon hormonal regulation; and (iii) the enzyme also catalyzes the steroid 17-20 lyase reaction, leading to the major androgens in the testis. Steroids 60-67 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 0-28 1924915-5 1991 It is concluded that OKT-3 and plasmapheresis combination therapy is very effective in reversing steroid-resistant rejections in high-risk patients such as ABO-incompatible cases. Steroids 97-104 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 156-159 2147411-3 1990 This drug causes involution of the thymic gland and at day 4 after steroid exposure a striking increase (up to 30 fold) in mRNA coding for ANP was observed. Steroids 67-74 natriuretic peptide A Rattus norvegicus 139-142 2147411-6 1990 The strong stimulation of the thymus ANP system subsequent to the glucocorticoid may suggest a critical function of this peptide in mechanisms leading to cellular depletion or during the regeneration of the gland after exposure to the steroid. Steroids 235-242 natriuretic peptide A Rattus norvegicus 37-40 8738480-10 1996 Glucuronidation of steroids, bile acids, fatty acids and drugs was effective in KYN-2 and Mz-Hep-1 cells. Steroids 19-27 DNL-type zinc finger Homo sapiens 93-98 8737385-11 1996 The weak expressions of c-fos and c-jun in the myometrium and in leiomyomata suggest that signalling pathways mediating steroid hormone action in endometrium and myometrium are different. Steroids 120-135 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 24-29 8737385-11 1996 The weak expressions of c-fos and c-jun in the myometrium and in leiomyomata suggest that signalling pathways mediating steroid hormone action in endometrium and myometrium are different. Steroids 120-135 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 34-39 31383257-5 2019 Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Steroids 239-246 neuropeptide B Oryzias latipes 82-85 8967783-9 1996 The observation that PLA2 induction could be completely inhibited by preincubation with dexamethasone allows new insights into the mechanism of steroid effects on epidermal inflammation and renders PLA2 regulation an interesting therapeutic target. Steroids 144-151 phospholipase A2, group IB, pancreas Mus musculus 21-25 19912775-7 1990 Since many studies have shown that neuronal development within sexually dimorphic areas of the hypothalamus and spinal cord is influenced by gonadal steroids around the time of birth, we hypothesized that Fos expression within such areas might differ between males and females at birth. Steroids 149-157 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 205-208 1979170-1 1990 Transcriptional activation by steroid hormones is often associated with the appearance of a DNase I hypersensitive site resulting from a local alteration of the nucleoprotein structure of the promoter. Steroids 30-46 deoxyribonuclease 1 Rattus norvegicus 92-99 31084464-7 2019 This autophagy-dependent steroid hormone regulation (ASHR) process is regulated by the wts-yki/Warts-Yorkie tumor-suppressor pathway downstream of nutrition, coupling nutrient intake with steroid-dependent developmental growth. Steroids 25-40 yorkie Drosophila melanogaster 91-94 2172247-8 1990 Thyroxine also stimulated expression of another female-predominant hepatic mRNA, encoding the steroid 16 alpha-hydroxylase cytochrome P-450f (IIC7), in a manner that was independent of the stimulatory effect of growth hormone on this transcript. Steroids 94-101 cytochrome P450, family 2, subfamily c, polypeptide 7 Rattus norvegicus 134-140 8772596-10 1996 Our data suggest that DHEAS levels may influence and/or be influenced by several endocrine and metabolic features of oldest-old people, depending on the sexual steroid milieu. Steroids 160-167 sulfotransferase family 2A member 1 Homo sapiens 22-27 31084464-7 2019 This autophagy-dependent steroid hormone regulation (ASHR) process is regulated by the wts-yki/Warts-Yorkie tumor-suppressor pathway downstream of nutrition, coupling nutrient intake with steroid-dependent developmental growth. Steroids 25-32 yorkie Drosophila melanogaster 91-94 8699412-10 1996 Thus, multiple cell types in cyclic mouse uteri express the gene encoding TNF-RI, and expression in specific cells is controlled by female steroid hormones. Steroids 139-155 tumor necrosis factor receptor superfamily, member 1a Mus musculus 74-80 2226332-0 1990 Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor. Steroids 49-56 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 76-99 29097006-1 2019 The KISS1 gene product, kisspeptin, stimulates gonadotrophic steroid hormone (GNRH) neuronal signaling through the G-protein coupled receptor, kiss1r. Steroids 61-68 metastasis-suppressor KiSS-1 Ovis aries 4-9 2172162-7 1990 Other steroids having glucocorticoid action mimicked this suppression of the ANF-mediated response. Steroids 6-14 natriuretic peptide A Rattus norvegicus 77-80 8833659-7 1996 To test the hypothesis that cJun plays an important role in steroid-evoked apoptosis, stable transfectants expressing Dex-regulable antisense c-jun RNA were established. Steroids 60-67 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 28-32 29097006-1 2019 The KISS1 gene product, kisspeptin, stimulates gonadotrophic steroid hormone (GNRH) neuronal signaling through the G-protein coupled receptor, kiss1r. Steroids 61-68 metastasis-suppressor KiSS-1 Ovis aries 24-34 2170421-4 1990 The induction of progesterone secretion is observed only after approximately 24 h and closely follows the delayed but quantitatively dramatic induction of the mitochondrial cytochrome P450scc which catalyzes the first step in steroid hormone biosynthesis. Steroids 226-241 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 173-191 8597585-2 1996 Because plasma has the ability to form PREG-FA and DHEA-FA in vitro from their unconjugated steroid counterparts, we postulated that the LCAT enzyme might be responsible for their formation. Steroids 92-99 lecithin-cholesterol acyltransferase Homo sapiens 137-141 31295971-2 2019 Measurement of testosterone is recommended in all of the current clinical guidelines but other steroids, such as androstenedione and dehydroepiandrosterone sulfate (DHEAS), have also been shown to be useful in diagnosing PCOS and may give additional information on metabolic risk. Steroids 95-103 sulfotransferase family 2A member 1 Homo sapiens 165-170 8867996-2 1996 The biologic activity of androgens is mediated through the formation of a non-covalent androgen receptor (AR)-steroid complex. Steroids 110-117 androgen receptor Rattus norvegicus 87-104 8867996-2 1996 The biologic activity of androgens is mediated through the formation of a non-covalent androgen receptor (AR)-steroid complex. Steroids 110-117 androgen receptor Rattus norvegicus 106-108 2387249-10 1990 These results show that glucocorticoid hormone interacts with the nuclear envelope via binding to the transformed glucocorticoid receptor, lending support to the two-step model of steroid hormone action. Steroids 180-195 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 114-137 8717430-7 1996 On withdrawal of the steroid, the activities of beta-glucuronidase, beta-N-acetyl glucosaminidase, beta-galactosidase are found to be increased in heart and kidney, whereas, the activity of alpha-mannosidase remains within normal values. Steroids 21-28 glucuronidase, beta Rattus norvegicus 48-66 31113804-2 2019 Shortly after receiving B-cell maturation antigen (BCMA)-targeted CAR T-cell therapy, the patient required urgent high-dose steroids and XRT for spinal cord compression. Steroids 124-132 TNF receptor superfamily member 17 Homo sapiens 51-55 8603033-2 1996 The steroid hormone 1 alpha,25(OH)2D3 is delivered to the various target organs of the VDE via a specific plasma transport protein, the vitamin D binding protein (DBP). Steroids 4-19 GC vitamin D binding protein Homo sapiens 136-161 2214775-9 1990 The sex-steroid action on the mCBG levels was discussed and compared with the mSBP levels. Steroids 8-15 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 30-34 2164924-8 1990 Competition binding analyses of various steroids for MR and GR revealed markedly different patterns of steroid binding specificity for these receptors. Steroids 40-47 nuclear receptor subfamily 3 group C member 1 Canis lupus familiaris 60-62 31113804-2 2019 Shortly after receiving B-cell maturation antigen (BCMA)-targeted CAR T-cell therapy, the patient required urgent high-dose steroids and XRT for spinal cord compression. Steroids 124-132 nuclear receptor subfamily 1 group I member 3 Homo sapiens 66-69 31354894-10 2019 Children having relapsing INS treated with steroids have higher levels of Scl and FGF-23 that can indicate the bone metabolism disorders. Steroids 43-51 fibroblast growth factor 23 Homo sapiens 82-88 2146099-6 1990 The demonstration of a clear-cut circadian oscillation in serum DHEA-S prompts studies on possible chrono-abnormalities of the steroid production in women with hyperandrogenic diseases. Steroids 127-134 sulfotransferase family 2A member 1 Homo sapiens 64-70 31039398-3 2019 11betaOHP4 is metabolised by 11betaHSD2 yielding 11-ketoprogesterone with 11betaHSD1 catalysing the reverse reaction, similar to the reduction of the other C11-oxy steroids. Steroids 164-172 aldo-keto reductase family 1 member C4 Homo sapiens 156-159 32138438-6 1990 Immunolocalization of 3beta-HSD can yield important information toward an understanding of adrenal steroid metabolism in both physiological and pathological processes. Steroids 99-106 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 22-31 2332444-0 1990 The steroid-dependent regulatory element in the ovalbumin gene does not function as a typical steroid response element. Steroids 4-11 ovalbumin (SERPINB14) Gallus gallus 48-57 8844777-0 1996 Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ: comparison with calcitonin gene-related peptide effects. Steroids 26-33 adrenomedullin Rattus norvegicus 0-14 30143819-6 2019 The CA-125 levels corresponded to clinical disease activity and improved with steroid therapy and rituximab. Steroids 78-85 mucin 16, cell surface associated Homo sapiens 4-10 8875796-0 1996 Successful management of hemolysis in ABO-nonidentical orthotopic liver transplantation by steroid therapy: a case report. Steroids 91-98 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 38-41 7588319-2 1995 Previously, we showed that the steroid"s effect on early macrophage precursors may be mediated through M-CSF, as the steroid enhances cytokine receptor expression. Steroids 31-38 colony stimulating factor 1 (macrophage) Mus musculus 103-108 7588319-6 1995 Steroid-induced M-CSF receptor enhancement reflects acceleration of protein appearance rather than overexpression, as treated and untreated cells ultimately exhibit equivalent binding. Steroids 0-7 colony stimulating factor 1 (macrophage) Mus musculus 16-21 2232362-2 1990 The changes found were: 1) After Tx and steroid therapy, in patients with MG who showed clinical improvement, the CD4/CD8 ratio and B lymphocyte subpopulations were markedly decreased. Steroids 40-47 CD8a molecule Homo sapiens 118-121 2232362-3 1990 2) Linear correlations between two T-cell subsets were evident in CD3 against CD4 and CD4/CD8 against CD4 after both Tx and steroid therapy. Steroids 124-131 CD8a molecule Homo sapiens 90-93 31410334-4 2019 The patient was found to have anti-GAD ab (+) CA and SPS and experienced significant symptomatic improvements after treatment with intravenous (IV) steroids followed by intravenous immunoglobulin (IVIG). Steroids 148-156 glutamate decarboxylase 1 Homo sapiens 35-38 2139185-1 1990 The present experiments were designed to assess the effects of central administration of atrial natriuretic peptide (ANP), alone or in conjunction with angiotensin II (AII), on luteinizing hormone (LH) and prolactin release in ovarian steroid-primed female rats. Steroids 235-242 natriuretic peptide A Rattus norvegicus 89-115 8571852-7 1995 When TM tissues respond to steroid hormone, the tissues synthesize and secret microfibrils and elastin, components of the elastic fibers. Steroids 27-42 elastin Homo sapiens 95-102 2404576-9 1990 Steroid autoradiography revealed a similar cellular distribution of AR. Steroids 0-7 androgen receptor Rattus norvegicus 68-70 31410334-7 2019 As there are only a few cases in the literature similar to this one, highlighting the successful treatment of anti-GAD ab cerebellar ataxia and SPS with dual therapy (steroids followed by IVIG) is important. Steroids 167-175 glutamate decarboxylase 1 Homo sapiens 115-118 31078066-6 2019 It has been revealed that pro-inflammatory cytokines such as IFN-gamma, TNF-alpha, TGF-beta, IL-17A, IL-27, IL-33 and thymic stromal lymphopoietin (TSLP) may contribute to steroid resistance in severe asthma and COPD. Steroids 172-179 interleukin 17A Homo sapiens 93-99 7591291-0 1995 Regulation of EGF-induced tenascin-C by steroids in tenascin-C-non-producing human carcinoma cells. Steroids 40-48 tenascin C Homo sapiens 26-36 2299346-1 1990 Radioiodinated bovine serum albumin conjugated to progesterone was used as a probe to examine binding parameters of steroids to membrane preparations from rat brain tissue. Steroids 116-124 albumin Rattus norvegicus 22-35 30984926-9 2019 Our data demonstrate that omega-3 potentiates the cellular development and steroid biosynthesis via CYP51 up-regulation in PCOS, which are mediated through the activation of the PI3K/Akt pathway. Steroids 75-82 cytochrome P450, family 51 Rattus norvegicus 100-105 2299346-2 1990 The binding of 11 alpha-hydroxyprogesterone-11-hemisuccinate-125I-bovine serum albumin conjugate reached saturation after 30 min of incubation at 5 degrees C. Several bovine serum albumin-conjugated steroids were then tested for competition displacement studies. Steroids 199-207 albumin Rattus norvegicus 73-86 2299346-2 1990 The binding of 11 alpha-hydroxyprogesterone-11-hemisuccinate-125I-bovine serum albumin conjugate reached saturation after 30 min of incubation at 5 degrees C. Several bovine serum albumin-conjugated steroids were then tested for competition displacement studies. Steroids 199-207 albumin Rattus norvegicus 174-187 2299346-3 1990 Among these steroid conjugates, the bovine serum albumin conjugate at position 3 of progesterone had the highest affinity, with an estimated inhibition constant of 28.5 +/- 2.1 nM (n = 3), whereas bovine serum albumin itself and the 17 beta-estradiol 6-(O-carboxy-methyl)oxime-bovine serum albumin conjugate showed no specific displacement. Steroids 12-19 albumin Rattus norvegicus 43-56 2299346-3 1990 Among these steroid conjugates, the bovine serum albumin conjugate at position 3 of progesterone had the highest affinity, with an estimated inhibition constant of 28.5 +/- 2.1 nM (n = 3), whereas bovine serum albumin itself and the 17 beta-estradiol 6-(O-carboxy-methyl)oxime-bovine serum albumin conjugate showed no specific displacement. Steroids 12-19 albumin Rattus norvegicus 204-217 2299346-3 1990 Among these steroid conjugates, the bovine serum albumin conjugate at position 3 of progesterone had the highest affinity, with an estimated inhibition constant of 28.5 +/- 2.1 nM (n = 3), whereas bovine serum albumin itself and the 17 beta-estradiol 6-(O-carboxy-methyl)oxime-bovine serum albumin conjugate showed no specific displacement. Steroids 12-19 albumin Rattus norvegicus 204-217 8563892-4 1995 Patients with non-refractory active UC receiving steroids showed levels of IL-1 beta and TNF-beta production similar to those in controls. Steroids 49-57 lymphotoxin alpha Homo sapiens 89-97 7584852-1 1995 The present study was conducted to investigate the effects of aging and medium supplements on steroid-induced ovalbumin mRNA in primary cultures of tubular gland cells from the chicken oviduct. Steroids 94-101 ovalbumin (SERPINB14) Gallus gallus 110-119 7584852-5 1995 The results indicated that the oviduct cells from immature chicks had clearer induction of ovalbumin mRNA by the steroid treatment than did those from laying hens. Steroids 113-120 ovalbumin (SERPINB14) Gallus gallus 91-100 1700972-1 1990 3 beta-Hydroxysteroid dehydrogenase (3 beta-HSD), which converts pregnenolone to progesterone, was localized immunohistochemically in 18 thecomas, 23 fibromas, 5 granulosa-cell tumors, 5 sclerosing stromal tumors, and 2 steroid-cell tumors. Steroids 14-21 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 37-47 31309031-4 2019 The mainstay of treatment for anti-LGI1 LE generally focuses on steroids, intravenous immunoglobulin (IVIG), plasmapheresis, and/or rituximab. Steroids 64-72 leucine rich glioma inactivated 1 Homo sapiens 35-39 1700972-7 1990 Immunoreactivity of 3 beta-HSD was present in cells in steroid-cell tumors and polygonal tumor cells with prominent cytoplasmic vacuoles in two cases of sclerosing stromal tumor. Steroids 55-62 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 20-30 2313638-0 1990 Expression of cellCAM-105 in the apical surface of rat uterine epithelium is controlled by ovarian steroid hormones. Steroids 99-115 CEA cell adhesion molecule 1 Rattus norvegicus 14-25 7584852-7 1995 The drastic induction of ovalbumin mRNA by ascorbic acid supplementation was exerted only when the steroid hormones were present in the medium, implying that the effect of ascorbic acid may be auxiliary in steroid-induced transcription of the ovalbumin gene. Steroids 99-106 ovalbumin (SERPINB14) Gallus gallus 25-34 7584852-7 1995 The drastic induction of ovalbumin mRNA by ascorbic acid supplementation was exerted only when the steroid hormones were present in the medium, implying that the effect of ascorbic acid may be auxiliary in steroid-induced transcription of the ovalbumin gene. Steroids 206-213 ovalbumin (SERPINB14) Gallus gallus 25-34 7584852-7 1995 The drastic induction of ovalbumin mRNA by ascorbic acid supplementation was exerted only when the steroid hormones were present in the medium, implying that the effect of ascorbic acid may be auxiliary in steroid-induced transcription of the ovalbumin gene. Steroids 206-213 ovalbumin (SERPINB14) Gallus gallus 243-252 31309031-5 2019 All the aforementioned modalities can be used in the treatment of anti-LGI1 LE and since this condition is highly responsive to treatment with steroids, prompt diagnosis can help stall the progression of this disease. Steroids 143-151 leucine rich glioma inactivated 1 Homo sapiens 71-75 2164232-4 1990 That testosterone altered the ability of flurazepam to protect mice from seizures is consistent with previous reports suggesting a complex interaction between steroids and the BDZ/GABAA system. Steroids 159-167 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 180-185 31026287-9 2019 However, a majority of the top upstream regulators of Pgrmc1 target genes were related to synthesis or activity of steroids, including P4, that exert neuroprotective effects. Steroids 115-123 progesterone receptor membrane component 1 Mus musculus 54-60 8577677-0 1995 Androgen receptor in the rat pancreas: genetic expression and steroid regulation. Steroids 62-69 androgen receptor Rattus norvegicus 0-17 33032228-8 2021 Expression of Calb2 and Gsta2 was altered by flusilazole but not triticonazole and may pinpoint novel pathways of disrupted testicular steroid synthesis. Steroids 135-142 calbindin 2 Rattus norvegicus 14-19 30655284-6 2019 Recombinant IL-17A and IL-17F showed opposite effects to the monoclonal antibodies.IL-17A and IL-17F exert distinct biological effects during airway inflammation of a TDI-induced asthma model, which is unresponsive to both inhaled and systemic steroids. Steroids 244-252 interleukin 17A Mus musculus 12-18 33032228-8 2021 Expression of Calb2 and Gsta2 was altered by flusilazole but not triticonazole and may pinpoint novel pathways of disrupted testicular steroid synthesis. Steroids 135-142 glutathione S-transferase alpha 2 Rattus norvegicus 24-29 8866837-0 1995 In vitro binding of 16-methylated C18 and C19 steroid derivatives to the androgen receptor. Steroids 46-53 androgen receptor Rattus norvegicus 73-90 30655284-6 2019 Recombinant IL-17A and IL-17F showed opposite effects to the monoclonal antibodies.IL-17A and IL-17F exert distinct biological effects during airway inflammation of a TDI-induced asthma model, which is unresponsive to both inhaled and systemic steroids. Steroids 244-252 interleukin 17A Mus musculus 83-89 7649107-3 1995 In the current report we established the mechanisms of the PKC-activating phorbol ester tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA) and the steroid hormone E2 on the induction of AR expression in human breast carcinoma cell lines. Steroids 155-162 amphiregulin Homo sapiens 194-196 25112708-11 2014 Patients with steroid-responsive EoE also showed a significant decrease in eotaxin-3/IL-5 expression at both oesophageal sites. Steroids 14-21 C-C motif chemokine ligand 26 Homo sapiens 75-84 30120913-11 2019 Four patients had muscle weakness, but three of them had normal serum CK levels that responded well to systemic steroids. Steroids 112-120 cytidine/uridine monophosphate kinase 1 Homo sapiens 70-72 30794798-7 2019 As compared to the thermodynamic parameters of 3alpha-HSD/CR acting on cyclohexanol, the hydrophobic interaction of the B-ring of steroids with the active site of 3alpha-HSD/CR contributes to catalysis by increasing exclusively the entropy of activation (DeltaTDeltaS = 1.8 kcal/mol), while the BCD-ring of androsterone significantly lowers DeltaDeltaH by 10.4 kcal/mol with a slight entropic penalty of -1.9 kcal/mol. Steroids 130-138 aldo-keto reductase family 1 member C4 Homo sapiens 47-57 18333700-1 2008 OBJECTIVE: The aim was to study the effect of climatotherapy and spa treatment on selected neuro- and immunomodulatory steroids known to affect well-being, and homocysteine, in a homogenous group of thyroidectomized women under standard substitution regime. Steroids 119-127 surfactant protein A2 Homo sapiens 65-68 34838827-2 2022 BACKGROUND: DHEA-S is among the main endogenous steroid hormones. Steroids 48-55 sulfotransferase family 2A member 1 Homo sapiens 12-18 8538866-0 1995 Gonadal steroid hormone regulation of proopiomelanocortin gene expression in arcuate neurons that innervate the medial preoptic area of the rat. Steroids 8-23 proopiomelanocortin Rattus norvegicus 38-57 8538866-3 1995 POMC mRNA level varies across the estrous cycle in the ARC and its expression is differentially altered by gonadal steroid hormones. Steroids 115-131 proopiomelanocortin Rattus norvegicus 0-4 8538866-4 1995 However, it is unclear how gonadal steroids regulate POMC gene expression in ARC neurons that innervate the MPOA. Steroids 35-43 proopiomelanocortin Rattus norvegicus 53-57 8538866-5 1995 Therefore, combined fluorogold (FG) retrograde neuronal labeling and in situ hybridization histochemistry were used to investigate the effects of gonadal steroid hormone treatment on POMC gene expression in ARC neurons supplying the MPOA of ovariectomized (OVX) female rats. Steroids 154-169 proopiomelanocortin Rattus norvegicus 183-187 8538866-13 1995 Gonadal steroid hormone treatment apparently affects POMC mRNA expression uniformly in neurons of the same ARC subdivision without regard to their efferent targets. Steroids 8-23 proopiomelanocortin Rattus norvegicus 53-57 7777858-6 1995 Thus, a TIMP-1-procathepsin L complex is a potent activator of steroidogenesis and may regulate steroid concentrations and, thus, germ cell development in both males and females. Steroids 63-70 TIMP metallopeptidase inhibitor 1 Rattus norvegicus 8-14 34480763-0 2022 Association between steroid use and nephropathy in patients who were administered a proton pump inhibitor: Analysis of the Japanese Adverse Event Report database. Steroids 20-27 ATPase H+/K+ transporting subunit alpha Homo sapiens 84-95 30794798-7 2019 As compared to the thermodynamic parameters of 3alpha-HSD/CR acting on cyclohexanol, the hydrophobic interaction of the B-ring of steroids with the active site of 3alpha-HSD/CR contributes to catalysis by increasing exclusively the entropy of activation (DeltaTDeltaS = 1.8 kcal/mol), while the BCD-ring of androsterone significantly lowers DeltaDeltaH by 10.4 kcal/mol with a slight entropic penalty of -1.9 kcal/mol. Steroids 130-138 aldo-keto reductase family 1 member C4 Homo sapiens 163-173 31061727-8 2019 The ratio of this steroid-dependent condition is higher in MOG-ON patients than the AQP4-ON group (p < 0.001). Steroids 18-25 aquaporin 4 Homo sapiens 84-88 34864062-9 2022 Moreover, it has been demonstrated that altered gene expression of VDR and 1,25D3-membrane-associated rapid response steroid-binding (1,25D3-MARRS) receptor influences the role of vitamin D within neurons and allows them to be more prone to degeneration. Steroids 117-124 vitamin D receptor Homo sapiens 67-81 30557606-5 2019 Here, we draw attention to the possible modulating influence of DHEA/DHEAS in early brain development from fetal life to the remarkable increase of these steroids in early childhood - the adrenarche. Steroids 154-162 sulfotransferase family 2A member 1 Homo sapiens 69-74 34851736-0 2022 Short Palate, Lung, and Nasal Epithelial Clone1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging. Steroids 75-82 BPI fold containing family A, member 1 Mus musculus 49-56 34851736-7 2022 RNAseq experiments of the aged lung revealed SPLUNC1 (Short Palate, Lung, and Nasal Epithelial Clone 1) as one of the steroid-responsive genes, which progressively declined with age and further by HDM-induced inflammation. Steroids 118-125 BPI fold containing family A, member 1 Mus musculus 45-52 34851736-10 2022 An age-dependent decline in the SPLUNC1 level may be involved in developing steroid-resistant airway inflammation and asthma heterogeneity. Steroids 76-83 BPI fold containing family A, member 1 Mus musculus 32-39 34921098-6 2021 Three members in this family were deorphaned in very recently: SLC22A14, SLC22A15 and SLC22A24, and found to transport specific compounds such as riboflavin (SLC22A14), anti-oxidant zwitterions (SLC22A15) and steroid conjugates (SLC22A24). Steroids 209-216 solute carrier family 22 member 14 Homo sapiens 63-71 8948449-1 1995 Using NADPH-cytochrome P-450 reductase as electron donor the homogeneous pig 17 alpha-hydroxylase-17,20-lyase (CYP17) was shown to catalyse the conversion of delta 5, as well as delta 4, steroids (pregnenolone and progesterone respectively) predominantly into the corresponding 17 alpha-hydroxylated products. Steroids 187-195 cytochrome P450 family 17 subfamily A member 1 Sus scrofa 111-116 7783195-1 1995 Within the 2.2 kb region between hsp23 and gene 1 of the small heat shock gene locus 67B1 of Drosophila melanogaster, an approximately 1 kb perturbation of the chromatin architecture has previously been observed to occur in response to the steroid hormone ecdysone. Steroids 240-255 Heat shock protein 23 Drosophila melanogaster 33-38 30884816-8 2019 Functional analysis of the relationship between DE-genes indicated that adiponectin interacts with genes that are involved in the processes of cell proliferation, programmed cell death, steroid and prostaglandin synthesis/metabolism, cytokine production, and cell adhesion that are critical for reproductive success. Steroids 186-193 adiponectin, C1Q and collagen domain containing Sus scrofa 72-83 7626503-4 1995 Glycosylation at the only phylogenetically conserved consensus site, Asn238-Gly239-Thr240, is essential for the biosynthesis of CBG with steroid-binding activity. Steroids 137-144 corticosteroid-binding globulin Cricetulus griseus 128-131 7626503-5 1995 Evidence has been obtained to support the hypothesis that transient carbohydrate-polypeptide interactions between Trp266 and the maturing carbohydrate chain at Asn238 occur during early stages of the CBG biosynthesis which affect protein folding and formation of the steroid-binding site. Steroids 267-274 corticosteroid-binding globulin Cricetulus griseus 200-203 7626503-6 1995 Another tryptophan residue, Trp371, has been found to be critical for CBG-steroid interactions and is likely located in the steroid-binding site. Steroids 74-81 corticosteroid-binding globulin Cricetulus griseus 70-73 7626503-6 1995 Another tryptophan residue, Trp371, has been found to be critical for CBG-steroid interactions and is likely located in the steroid-binding site. Steroids 124-131 corticosteroid-binding globulin Cricetulus griseus 70-73 34890298-0 2022 Upregulation of microRNA-576-5p protects from steroid-induced avascular necrosis of the femoral head by suppressing ANXA2. Steroids 46-53 annexin A2 Oryctolagus cuniculus 116-121 30605780-11 2019 Gossypol acetate weakly inhibited retinol dehydrogenase 2 with IC50 value over 1 x 10-4 M. Molecular docking analysis showed that gossypol partially bound to the steroid-binding site of the crystal structure of rat 3alpha-hydroxysteroid dehydrogenase. Steroids 162-169 aldo-keto reductase family 1, member C14 Rattus norvegicus 215-250 34228315-9 2021 Taken together, these results reveal previously unknown functions of SRC3 in the hippocampus and thus may provide insight into how steroid hormones regulate brain function. Steroids 131-138 nuclear receptor coactivator 3 Mus musculus 69-73 7651620-0 1995 Acute injection of adrenal steroids reduces cornea-evoked expression of c-fos within the spinal trigeminal nucleus of adrenalectomized rats. Steroids 27-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 72-77 7651620-1 1995 The influence of transient increases in adrenal steroid hormones on the number of Fos-positive neurons after nociceptor activation was assessed in adrenalectomized rats. Steroids 48-55 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 82-85 7651620-8 1995 Acute administration of adrenal steroids to adrenalectomized rats greatly attenuated the number of Fos-positive neurons seen after corneal stimulation within select portions of trigeminal subnucleus caudalis. Steroids 32-40 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 99-102 30664681-5 2019 In this Review, we focus on evolving concepts regarding the roles of fibroblast growth factor 23 (FGF23), inflammation and systemic oxidant stress and their interactions with more established mechanisms such as pressure and volume overload resulting from hypertension and anaemia, respectively, activation of the renin-angiotensin and sympathetic nervous systems, activation of the transforming growth factor-beta (TGFbeta) pathway, abnormal mineral metabolism and increased levels of endogenous cardiotonic steroids. Steroids 508-516 fibroblast growth factor 23 Homo sapiens 69-96 7651620-10 1995 These results are consistent with the hypothesis that transient increases in adrenal steroids, such as occur after injury, are sufficient to modify the production of Fos protein in central neurons that process nociceptive information. Steroids 85-93 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 166-169 34827948-0 2021 Steroid Receptor Coregulators Can Modulate the Action of Progesterone Receptor during the Estrous Cycle in Cow Endometrium. Steroids 0-7 progesterone receptor Bos taurus 57-78 34561233-1 2021 Sex steroid hormones act on hypothalamic kisspeptin neurons to regulate reproductive neural circuits in the brain. Steroids 4-11 KiSS-1 metastasis-suppressor Mus musculus 41-51 34561233-2 2021 Kisspeptin neurons start to express estrogen receptors (ERs) in utero, suggesting steroid hormone action on these cells early during development. Steroids 82-89 KiSS-1 metastasis-suppressor Mus musculus 0-10 7753868-0 1995 LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. Steroids 91-107 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-4 30530158-4 2019 Then Inhibition of NO production significantly inhibited the expression of CYP19A1, a key gene that is involved in sex steroid hormones synthesis and is responsible for the decrease of E2. Steroids 119-135 cytochrome P450 family 19 subfamily A member 1 Capra hircus 75-82 7753868-5 1995 LEM1 appears to affect certain steroids and not others. Steroids 31-39 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-4 34561233-9 2021 Embryonic kisspeptin neurons in the hypothalamus express steroid hormone receptors, suggesting hormone action on these cells in utero. Steroids 57-64 KiSS-1 metastasis-suppressor Mus musculus 10-20 34581822-7 2021 In ESCs, HAND2 expression significantly increased throughout the 12 days treatment with steroid hormones, whereas FOXO1 expression significantly increased on day 1, reached a plateau, and significantly increased again after 6 days of treatment. Steroids 88-95 heart and neural crest derivatives expressed 2 Homo sapiens 9-14 7753868-6 1995 We propose that transporters like LEM1 can selectively modulate the intracellular levels of steroid hormones. Steroids 92-108 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 34-38 30595381-8 2019 The validity of StAR protein acetylation and its correlation to HDAC inhibition mediated steroid synthesis was demonstrated in adrenocortical tumor H295R cells. Steroids 89-96 histone deacetylase 9 Homo sapiens 64-68 34463738-10 2021 Furthermore, the hormones regulating OCT4 and ERbeta expressions were regulated by cytochrome P450 lanosterol 14a-demethylase (CYP51), a key enzyme in sterol and steroid biosynthesis. Steroids 162-169 POU domain, class 5, transcription factor 1 Mus musculus 37-41 7628802-7 1995 Since CYP2C is the same most abundant enzyme as 3A subfamily P450 in human liver and plays a major role for metabolism of many drugs used clinically, and may also play an important role for metabolism of some steroid hormones, we further studied the inhibition of CYP2C-catalyzed steroid metabolism by typical PCB congeners. Steroids 209-216 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 6-11 31172974-1 2019 Within the mammalian reproductive system sirtuin 1 and 6 (SIRT1, SIRT6) are considered to contribute to steroid hormone signaling and control of reproductive physiology. Steroids 104-119 sirtuin 1 Homo sapiens 41-56 7628802-7 1995 Since CYP2C is the same most abundant enzyme as 3A subfamily P450 in human liver and plays a major role for metabolism of many drugs used clinically, and may also play an important role for metabolism of some steroid hormones, we further studied the inhibition of CYP2C-catalyzed steroid metabolism by typical PCB congeners. Steroids 280-287 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 6-11 31172974-1 2019 Within the mammalian reproductive system sirtuin 1 and 6 (SIRT1, SIRT6) are considered to contribute to steroid hormone signaling and control of reproductive physiology. Steroids 104-119 sirtuin 1 Homo sapiens 58-63 7710689-1 1995 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of DHEA and other steroids. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 0-39 7710689-1 1995 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of DHEA and other steroids. Steroids 102-110 sulfotransferase family 2A member 1 Homo sapiens 41-48 34692525-5 2021 VDR is a nuclear steroid hormone receptor activated by 1,25 dihydroxy-vitamin D3 (calcitriol, 1,25(OH)2D3). Steroids 17-24 vitamin D receptor Homo sapiens 0-3 30287909-8 2019 These data together with those reporting that the CYP3A4 and ESR2 SNPs correlate with the expression of TRIM4 and ESR2 mRNAs in PBMCs (ranging from P = 1.98 x 10-6 to P = 2.0 x 10-35), and that the CYP2C9rs1799853 SNP modulates the efficiency of multiple drugs, suggest that steroid hormone-related genes may have a role in determining the response to anti-TNF drugs.KEY POINTS Polymorphisms within the CYP3A4 and CYP2C9 loci correlate with changes in DAS28 after treatment with anti-TNF drugs. Steroids 275-290 tripartite motif containing 4 Homo sapiens 104-109 34686542-14 2021 All PET-positive patients were previously treated with a high dose of steroids and intravenous immunoglobulin prior to PET/CT had elevated serum cTnI except for one patient for whom PET/CT was delayed several days. Steroids 70-78 troponin I3, cardiac type Homo sapiens 145-149 7790446-0 1995 Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia. Steroids 68-75 cathepsin G Rattus norvegicus 53-64 30676120-12 2019 In a logistic regression analysis, age (adjusted OR: 1.051; CI: 1.032-1.071), and the use of proton pump inhibitors (adjusted OR: 3.843; CI: 2.338-6.316), non-steroid anti-inflammatory drugs (adjusted OR: 2.411; CI: 1.162-5.002) and acetylsalicylic acid (adjusted OR: 2.934; CI: 1.085-3.448) were significantly associated with an elevated FC (>50 microg/g). Steroids 159-166 ATPase H+/K+ transporting subunit alpha Homo sapiens 93-104 7784451-6 1995 Among these, the levels of Gi alpha 1 and 2 appears to be regulated by steroid hormones. Steroids 71-87 guanine nucleotide binding protein (G protein), alpha inhibiting 1 Mus musculus 27-43 7574443-9 1995 In the rat, GH-BP and GH-R are regulated by nutritional and endocrine factors, among those are GH, insulin and gonadal steroids. Steroids 119-127 growth hormone receptor Homo sapiens 12-17 34588570-5 2021 The findings presented herein indicate that DEX or TGFbeta2 resulted in mild and severe down-sized and stiff 3D HTM spheroids, respectively, thus making them viable in vitro HTM models for steroid-induced and primary open angle glaucoma. Steroids 189-196 transforming growth factor beta 2 Homo sapiens 51-59 7574443-9 1995 In the rat, GH-BP and GH-R are regulated by nutritional and endocrine factors, among those are GH, insulin and gonadal steroids. Steroids 119-127 growth hormone receptor Rattus norvegicus 22-26 30616547-2 2019 A subset of asthma patients also exhibits elevated IL-17, which is associated with greater disease severity, neutrophilic inflammation, and steroid resistance. Steroids 140-147 interleukin 17A Homo sapiens 51-56 7749143-2 1995 In humans, very high levels of DHEA and/or dehydroepiandrosterone sulfate (DHEAS) have been found in breast tissues and secretions, and epidemiological studies suggest a role of these steroids in the modulation of breast cancer growth. Steroids 184-192 sulfotransferase family 2A member 1 Homo sapiens 75-80 34175410-4 2021 We also outline the consequences of specific defects in steroid biosynthesis, as revealed by evidence from genetically engineered zebrafish models, including cyp11a2, cyp21a2, hsd3b1, cyp11c1 and fdx1b deficiency. Steroids 56-63 cytochrome P450, family 21, subfamily A, polypeptide 2 Danio rerio 167-174 34175410-4 2021 We also outline the consequences of specific defects in steroid biosynthesis, as revealed by evidence from genetically engineered zebrafish models, including cyp11a2, cyp21a2, hsd3b1, cyp11c1 and fdx1b deficiency. Steroids 56-63 cytochrome P450, family 11, subfamily C, polypeptide 1 Danio rerio 184-191 34271496-3 2021 Progesterone receptor expression is regulated by gonadal steroid hormones and therefore may change throughout the oestrous cycle. Steroids 57-64 progesterone receptor Felis catus 0-21 34595348-0 2021 lncRNA NEAT1 regulates CYP1A2 and influences steroid-induced necrosis. Steroids 45-52 nuclear paraspeckle assembly transcript 1 Homo sapiens 7-12 7553703-3 1995 Moreover, common factors unique to women including pregnancy, oophorectomy, menopause, and use of steroid hormones, appear to have an impact on CHD risk that is often poorly understood. Steroids 98-114 choline dehydrogenase Homo sapiens 144-147 7835088-1 1995 The enzyme 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) catalyses an essential step in the biosynthesis of all steroid hormones. Steroids 141-157 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 74-84 30383540-0 2019 An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup. Steroids 60-67 interleukin 17A Homo sapiens 21-27 7828529-0 1995 A comparison of the esterification of steroids by rat lecithin:cholesterol acyltransferase and acyl coenzyme A:cholesterol acyltransferase. Steroids 38-46 lecithin cholesterol acyltransferase Rattus norvegicus 54-90 7828529-15 1995 These results show that all of the steroids tested are esterified by LCAT, and consequently that blood LCAT is the probable source of the circulating steroidal esters. Steroids 35-43 lecithin cholesterol acyltransferase Rattus norvegicus 69-73 34497262-3 2021 CYP2C19, which is expressed in the human fetal brain during neurodevelopment, shows affinity for endogenous compounds including monoaminergic neurotransmitters, steroid hormones, and endocannabinoids. Steroids 161-168 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 0-7 34446511-6 2021 She was treated with steroids which resulted in immediate cognitive and motor improvements as well as resolution of her urinary incontinence. Steroids 21-29 Src homology 2 domain containing E Homo sapiens 0-3 34485929-1 2021 Human cytochromes P45011beta (CYP11B1) and P450aldo (CYP11B2) are monooxygenases that synthesize cortisol through steroid 11beta-hydroxylation and aldosterone through a three-step process comprising 11beta-hydroxylation and two 18-hydroxylations, respectively. Steroids 114-121 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 30-37 7828533-0 1995 Steroid regulation of growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids in the rat. Steroids 0-7 growth hormone receptor Rattus norvegicus 22-50 30551361-0 2019 MiR-217 promotes cell proliferation and osteogenic differentiation of BMSCs by targeting DKK1 in steroid-associated osteonecrosis. Steroids 97-104 microRNA 217 Homo sapiens 0-7 7707287-3 1995 The inhibitory effect of tamoxifen on oxytocin-induced phospholipase C activation occurred in both steroid-free and complete culture medium; it was time- and concentration-dependent and was only partly reversed by oestradiol. Steroids 99-106 oxytocin/neurophysin I prepropeptide Homo sapiens 38-46 34436366-9 2021 CD45+, CD3+CD4+ (Th cell), CD3+CD8+, CD4+/CD8+, the NK cell subpopulation, neutrophils, monocytes, and basophils were significantly reduced by Steroids + Tocilizumab without an effect modification by VV-ECMO support. Steroids 143-151 CD8a molecule Homo sapiens 31-34 34436366-9 2021 CD45+, CD3+CD4+ (Th cell), CD3+CD8+, CD4+/CD8+, the NK cell subpopulation, neutrophils, monocytes, and basophils were significantly reduced by Steroids + Tocilizumab without an effect modification by VV-ECMO support. Steroids 143-151 CD8a molecule Homo sapiens 42-45 30551361-2 2019 This study aims to explore the expression profile and biological function of miR-217, which is known to be related to tumor cell proliferation and migration, to the proliferation and osteogenic differentiation of MSCs from the patients with steroid-associated osteonecrosis (ONFH). Steroids 241-248 microRNA 217 Homo sapiens 77-84 7617114-0 1995 Association of DQB1*0302 alloantigens in Japanese pediatric patients with steroid-sensitive nephrotic syndrome. Steroids 74-81 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 15-19 30551361-9 2019 These findings suggest that miR-217 promotes cell proliferation and osteogenic differentiation by inhibiting DKK1 during the development of steroid-associated osteonecrosis. Steroids 140-147 microRNA 217 Homo sapiens 28-35 34288113-2 2021 Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Steroids 125-132 nuclear receptor subfamily 5, group A, member 1 Mus musculus 0-22 31028003-8 2019 These observations confirm the involvement of CREB-1 in the control of ovarian cell proliferation, apoptosis, and steroid hormone release. Steroids 114-129 cAMP responsive element binding protein 1 Homo sapiens 46-52 34288113-2 2021 Steroidogenic factor-1 (NR5A1) plays a central role in the development of steroidogenic tissues and their ability to produce steroid hormones. Steroids 125-132 nuclear receptor subfamily 5, group A, member 1 Mus musculus 24-29 34395283-4 2021 TCF3-ZNF384 fusion is related to a poor steroid response and a high frequency of relapse. Steroids 40-47 zinc finger protein 384 Homo sapiens 5-11 7713192-2 1994 An important site of steroid action may be on the control of the activator protein-1 (AP-1) binding to deoxyribonucleic acid (DNA). Steroids 21-28 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 65-84 7713192-2 1994 An important site of steroid action may be on the control of the activator protein-1 (AP-1) binding to deoxyribonucleic acid (DNA). Steroids 21-28 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 86-90 30414016-5 2019 In this chapter, we will briefly tap into the complex network of steroid hormone modulation of neurogenesis in the hippocampus with specific emphasis on stress, testosterone, and estrogen. Steroids 65-80 nuclear RNA export factor 1 Homo sapiens 33-36 7825911-0 1994 The role of lipocortin 1 (LC1) in the steroid feedback control of hypothalamo-pituitary-adrenocortical function. Steroids 38-45 annexin A1 Homo sapiens 12-24 7825911-0 1994 The role of lipocortin 1 (LC1) in the steroid feedback control of hypothalamo-pituitary-adrenocortical function. Steroids 38-45 annexin A1 Homo sapiens 26-29 7955120-4 1994 Interestingly, significant inhibition was observed at concentrations of DHEAS which are comparable to peak serum levels of this steroid occurring in the second decade of life. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 72-77 34381494-0 2021 ARG2, MAP4K5 and TSTA3 as Diagnostic Markers of Steroid-Induced Osteonecrosis of the Femoral Head and Their Correlation With Immune Infiltration. Steroids 48-55 arginase 2 Homo sapiens 0-4 34381494-0 2021 ARG2, MAP4K5 and TSTA3 as Diagnostic Markers of Steroid-Induced Osteonecrosis of the Femoral Head and Their Correlation With Immune Infiltration. Steroids 48-55 GDP-L-fucose synthase Homo sapiens 17-22 30278258-0 2019 MiR-31 and miR-143 affect steroid hormone synthesis and inhibit cell apoptosis in bovine granulosa cells through FSHR. Steroids 26-41 microRNA 143 Bos taurus 11-18 34089930-0 2021 Adiponectin modulates steroid hormone secretion, granulosa cell proliferation and apoptosis via binding its receptors during hens" high laying period. Steroids 22-29 adiponectin, C1Q and collagen domain containing Gallus gallus 0-11 34089930-6 2021 Taken together, the study highlighted the role of adiponectin and its receptors in the regulation of steroid synthesis and secretion in ovarian granulosa cells in laying hens. Steroids 101-108 adiponectin, C1Q and collagen domain containing Gallus gallus 50-61 7523375-5 1994 Steroid treatment (dexamethasone, 1 microM) specifically induced c-Ha-ras(Asn-17) protein and mRNA and blocked IL-3-induced accumulation of p21ras-GTP in 32Dcl3/p21rasN17 cell lines, but not in control cells. Steroids 0-7 Harvey rat sarcoma virus oncogene Mus musculus 67-73 7523375-5 1994 Steroid treatment (dexamethasone, 1 microM) specifically induced c-Ha-ras(Asn-17) protein and mRNA and blocked IL-3-induced accumulation of p21ras-GTP in 32Dcl3/p21rasN17 cell lines, but not in control cells. Steroids 0-7 Harvey rat sarcoma virus oncogene Mus musculus 140-146 7854057-4 1994 In this study we have used in situ hybridization to investigate the adrenal steroid regulation of the mRNAs encoding the neurotrophic factors BDNF, NT-3, and bFGF, their respective receptors, and the growth-associated protein GAP-43. Steroids 76-83 brain-derived neurotrophic factor Rattus norvegicus 142-146 34187427-0 2021 DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head. Steroids 65-72 basic transcription factor 3 pseudogene 11 Homo sapiens 23-26 30278258-10 2019 Taken together, our results indicate that miR-31 and miR-143 decrease steroid hormone synthesis and inhibit bovine GC apoptosis by targeting FSHR. Steroids 70-85 microRNA 143 Bos taurus 53-60 34187427-0 2021 DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head. Steroids 65-72 TNF superfamily member 11 Homo sapiens 32-37 34187427-1 2021 BACKGROUND: Dysregulation of the OPG/RANK/RANKL signalling pathway is a key step in the occurrence of steroid-induced osteonecrosis of the femoral head (ONFH). Steroids 102-109 basic transcription factor 3 pseudogene 11 Homo sapiens 33-36 31384438-3 2019 We report the clinical outcome of 17 Indian C3G patients treated with MMF with or without steroids. Steroids 90-98 Rap guanine nucleotide exchange factor 1 Homo sapiens 44-47 34187427-1 2021 BACKGROUND: Dysregulation of the OPG/RANK/RANKL signalling pathway is a key step in the occurrence of steroid-induced osteonecrosis of the femoral head (ONFH). Steroids 102-109 TNF superfamily member 11 Homo sapiens 42-47 34187427-2 2021 This study aims to understand the degree of methylation of the OPG, RANK, and RANKL genes in steroid-related ONFH. Steroids 93-100 basic transcription factor 3 pseudogene 11 Homo sapiens 63-66 34187427-2 2021 This study aims to understand the degree of methylation of the OPG, RANK, and RANKL genes in steroid-related ONFH. Steroids 93-100 TNF superfamily member 11 Homo sapiens 78-83 34187427-7 2021 RESULTS: In the CpG islands of the OPG, RANK, and RANKL genes in patients with steroid-related ONFH, several CpG sites with high methylation rates and high methylation levels were found. Steroids 79-86 basic transcription factor 3 pseudogene 11 Homo sapiens 35-38 34187427-7 2021 RESULTS: In the CpG islands of the OPG, RANK, and RANKL genes in patients with steroid-related ONFH, several CpG sites with high methylation rates and high methylation levels were found. Steroids 79-86 TNF superfamily member 11 Homo sapiens 50-55 7925132-11 1994 In summary, 1) an episode of increased LHRH release occurs before and during the progesterone-induced LH surge; 2) acceleration of LHRH pulse frequency and the increase in LHRH pulse amplitude after progesterone are accompanied by acceleration of NPY pulse frequency; and 3) ovarian steroids do not affect the temporal correlation between NPY and LHRH pulses. Steroids 283-291 neuropeptide Y Macaca mulatta 247-250 34187427-10 2021 CONCLUSION: Methylation of certain sites in the OPG/RANK/RANKL signalling pathway increases the risk of steroid-related ONFH. Steroids 104-111 basic transcription factor 3 pseudogene 11 Homo sapiens 48-51 30558534-9 2018 In Holstein cows, the salmon module with module trait relationship (MTR) = 0.7 and the top upstream regulators ATP7B were involved in cholesterol biosynthesis, steroid biosynthesis, lipid biosynthesis and fatty acid metabolism. Steroids 160-167 ATPase copper transporting beta Bos taurus 111-116 34187427-10 2021 CONCLUSION: Methylation of certain sites in the OPG/RANK/RANKL signalling pathway increases the risk of steroid-related ONFH. Steroids 104-111 TNF superfamily member 11 Homo sapiens 57-62 7837152-13 1994 The therapeutic effect of steroid in PMR may be partially mediated by its effect on CD8 activated cells. Steroids 26-33 CD8a molecule Homo sapiens 84-87 7854350-8 1994 These results indicate that at least part of glucocorticoid regulation of WAP gene expression is mediated through the direct interaction of GR with glucocorticoid response elements in the distal promoter region resulting in steroid hormone-dependent alterations in chromatin structure. Steroids 224-239 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 140-142 34130686-10 2021 CONCLUSIONS: FDX1 was related with steroid metabolism and mitochondrial and may participate in the development of PCOS. Steroids 35-42 ferredoxin 1 Homo sapiens 13-17 30568655-14 2018 Most GFAP astrocytopathy patients respond well to steroid therapy although some patients are prone to relapse or even die. Steroids 50-57 glial fibrillary acidic protein Homo sapiens 5-9 34122327-8 2021 These sex steroid effects affected both CD4+ and CD8+ cells and yet interference with the testosterone surge only significantly de-masculinized the splenic content of CD4+ cells. Steroids 10-17 CD4 antigen Mus musculus 40-43 7521210-1 1994 The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Steroids 19-26 heat shock protein family A (Hsp70) member 4 Homo sapiens 98-103 7521210-1 1994 The nontransformed steroid receptors contain several non-steroid binding proteins, such as hsp90, hsp70, and p59. Steroids 19-26 HLA complex P5B Homo sapiens 109-112 34122327-8 2021 These sex steroid effects affected both CD4+ and CD8+ cells and yet interference with the testosterone surge only significantly de-masculinized the splenic content of CD4+ cells. Steroids 10-17 CD4 antigen Mus musculus 167-170 30273606-6 2018 These data indicate that in contrast to the current view, and similar to humans, mouse adrenals synthesize significant amounts of steroids that contribute to the androgen receptor-dependent growth of CRPC. Steroids 130-138 androgen receptor Mus musculus 162-179 34194927-0 2021 Steroids Enable Mesenchymal Stromal Cells to Promote CD8+ T Cell Proliferation Via VEGF-C. Steroids 0-8 CD8a molecule Homo sapiens 53-56 7660717-2 1994 Placental microsomes are involved in the metabolism of steroid hormones via NADPH cytochrome P450 reductase; this last enzyme is involved in the generation of O2 and H2O2. Steroids 55-71 cytochrome p450 oxidoreductase Rattus norvegicus 76-107 8071335-10 1994 Moreover, DBI and a PBR synthetic ligand were able to increase steroid production in isolated R2C cell mitochondria which express the 5 nM affinity receptor. Steroids 63-70 translocator protein Rattus norvegicus 20-23 7964290-2 1994 Since, in previous studies in the rabbit, sex steroids greatly affected uterine endothelin-1 (ET-1) immunolocalization and binding, we sought to compare results obtained in a relatively steroid-deprived uterus (postmenopausal women) with those obtained in late pregnancy. Steroids 46-54 endothelin-1 Oryctolagus cuniculus 80-92 30221552-4 2018 Steroids displaying pendants and functional groups of the carboxylate, phenolic or sulfonate types appended at the tetracyclic ring were shown to inhibit the cytosolic CA II and the tumor-associated, transmembrane CA IX in a medium micromolar range (38.9-89.9 microM). Steroids 0-8 carbonic anhydrase 2 Homo sapiens 168-173 7964290-2 1994 Since, in previous studies in the rabbit, sex steroids greatly affected uterine endothelin-1 (ET-1) immunolocalization and binding, we sought to compare results obtained in a relatively steroid-deprived uterus (postmenopausal women) with those obtained in late pregnancy. Steroids 46-54 endothelin-1 Oryctolagus cuniculus 94-98 7964290-2 1994 Since, in previous studies in the rabbit, sex steroids greatly affected uterine endothelin-1 (ET-1) immunolocalization and binding, we sought to compare results obtained in a relatively steroid-deprived uterus (postmenopausal women) with those obtained in late pregnancy. Steroids 46-53 endothelin-1 Oryctolagus cuniculus 94-98 8051160-7 1994 The interactions of AR and GR with IDE may have important implications for both insulin- and steroid-mediated signaling. Steroids 93-100 insulin degrading enzyme Homo sapiens 35-38 35616132-0 2022 MicroRNA-141 inhibits the differentiation of bone marrow-derived mesenchymal stem cells in steroid-induced osteonecrosis via E2F3. Steroids 91-98 E2F transcription factor 3 Rattus norvegicus 125-129 30557999-5 2018 Among these cytokines and soluble adhesion molecules, soluble intercellular adhesion molecule-1 (sICAM-1) and interferon-gamma-inducible protein 10 (IP-10) were most downregulated by steroid therapy in AIH patients. Steroids 183-190 C-X-C motif chemokine ligand 10 Homo sapiens 110-147 35150312-1 2022 BACKGROUND: Prophylaxis against infusion-related reactions (IRR) from paclitaxel with steroids and antihistamines is a standard of care due to high rates of IRR. Steroids 86-94 insulin receptor related receptor Homo sapiens 60-63 35150312-1 2022 BACKGROUND: Prophylaxis against infusion-related reactions (IRR) from paclitaxel with steroids and antihistamines is a standard of care due to high rates of IRR. Steroids 86-94 insulin receptor related receptor Homo sapiens 157-160 7976510-1 1994 The profile of structural preference for the ligand binding domain of the human vitamin D binding protein (DBP) was determined by steroid competition assay of 71 analogs of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3]. Steroids 130-137 GC vitamin D binding protein Homo sapiens 80-105 30557999-5 2018 Among these cytokines and soluble adhesion molecules, soluble intercellular adhesion molecule-1 (sICAM-1) and interferon-gamma-inducible protein 10 (IP-10) were most downregulated by steroid therapy in AIH patients. Steroids 183-190 C-X-C motif chemokine ligand 10 Homo sapiens 149-154 30557999-10 2018 Circulating M2BPGi levels were significantly reduced by steroid treatment in AIH patients.sICAM-1 and IP-10 are useful markers to assess immune-mediated hepatitis activity in AIH and they correlate with circulating M2BPGi. Steroids 56-63 C-X-C motif chemokine ligand 10 Homo sapiens 102-107 7952267-3 1994 Modulators of GFAP expression include steroids, cytokines, and growth factors. Steroids 38-46 glial fibrillary acidic protein Homo sapiens 14-18 30524245-1 2018 Low back pain, a leading cause of disability, is commonly treated by epidural steroid injections that target the anti-inflammatory glucocorticoid receptor (GR). Steroids 78-85 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 131-154 7952267-4 1994 GFAP expression also shows brain region-specific responses to sex steroids and of astrocyte-neuronal interactions. Steroids 66-74 glial fibrillary acidic protein Homo sapiens 0-4 7950980-2 1994 Despite this mutation, a smaller sized protein corresponding to the DNA- and steroid-binding domain of the AR can be synthesized from the cloned Tfm AR cDNA by in vitro translation. Steroids 77-84 androgen receptor Mus musculus 107-109 35459945-3 2022 WHAT IS KNOWN ALREADY: AMPK is expressed in the ovarian follicle, and its activation by pharmacological medications, such as metformin, inhibits the production of steroids. Steroids 163-171 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 23-27 35459945-21 2022 WIDER IMPLICATIONS OF THE FINDINGS: Our results reveal that AMPK is directly involved in steroid production in human GCs. Steroids 89-96 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 60-64 30524245-1 2018 Low back pain, a leading cause of disability, is commonly treated by epidural steroid injections that target the anti-inflammatory glucocorticoid receptor (GR). Steroids 78-85 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 156-158 7950980-6 1994 These data suggest that although the Tfm AR mRNA fails to produce a full-length AR because of the frame-shift mutation, a smaller protein capable of binding both steroid and DNA can be produced by translation from an internal initiation codon. Steroids 162-169 androgen receptor Mus musculus 41-43 30524245-12 2018 The results suggest that EPL may enhance the effectiveness of clinically used epidural steroid injections, in part by enhancing the availability of the GR. Steroids 87-94 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 152-154 35099763-0 2022 A novel NPHS2 mutation (c.865A > G) identified in a Chinese family with steroid-resistant nephrotic syndrome alters subcellular localization of nephrin. Steroids 72-79 NPHS1 adhesion molecule, nephrin Homo sapiens 144-151 30524245-13 2018 Thus, the glucocorticoid-mineralocorticoid interactions may limit the effectiveness of epidural steroids through the regulation of the GR in the DRG. Steroids 96-104 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 135-137 8075850-5 1994 Dexamethasone caused a time-dependent biphasic translocation of lipocortin 1 from the intracellular compartment to the cell membrane with maximal membrane expression at 4 and 24 h. In differentiated U-937 cells the steroid-induced membrane accumulation of lipocortin 1 was significantly higher than that of undifferentiated cells. Steroids 215-222 annexin A1 Homo sapiens 64-76 30110567-2 2018 Recently, mutations in scaffold protein membrane-associated guanylate kinase inverted 2 (MAGI-2) encoding gene were identified among the etiology of steroid-resistant nephrotic syndrome. Steroids 149-156 membrane associated guanylate kinase, WW and PDZ domain containing 2 Homo sapiens 89-95 8075850-5 1994 Dexamethasone caused a time-dependent biphasic translocation of lipocortin 1 from the intracellular compartment to the cell membrane with maximal membrane expression at 4 and 24 h. In differentiated U-937 cells the steroid-induced membrane accumulation of lipocortin 1 was significantly higher than that of undifferentiated cells. Steroids 215-222 annexin A1 Homo sapiens 256-268 8040619-9 1994 When PAF was administered to female adult rats pretreated with sex steroid hormones, the mortality of the rats with low plasma PAF-AH activity caused by estrogen was increased, but decreased in the animals with high enzyme activity caused by progestin. Steroids 67-83 PCNA clamp associated factor Rattus norvegicus 5-8 8040619-9 1994 When PAF was administered to female adult rats pretreated with sex steroid hormones, the mortality of the rats with low plasma PAF-AH activity caused by estrogen was increased, but decreased in the animals with high enzyme activity caused by progestin. Steroids 67-83 PCNA clamp associated factor Rattus norvegicus 127-130 35529881-4 2022 The BAL lymphocytosis consisted of T cells, while the mean CD4/CD8 ratio was 1.80 in non-steroid- treated patients and 1.14 in steroid-treated patients. Steroids 89-96 CD8a molecule Homo sapiens 63-66 35529881-4 2022 The BAL lymphocytosis consisted of T cells, while the mean CD4/CD8 ratio was 1.80 in non-steroid- treated patients and 1.14 in steroid-treated patients. Steroids 127-134 CD8a molecule Homo sapiens 63-66 30169894-9 2018 In conclusion, we demonstrate that FKBP51 has the potential to control inflammation in steroid insensitive patients in a steroid-dependent and independent manner and thus may be worthy of further study as a drug target. Steroids 87-94 FK506 binding protein 5 Mus musculus 35-41 35245460-4 2022 We show here that the dietary lipid cholesterol, which is required as a component of cell membranes and as a substrate for steroid biosynthesis, also governs body growth and maturation in Drosophila via promoting the expression and release of insulin-like peptides. Steroids 123-130 Insulin-like receptor Drosophila melanogaster 243-250 8174720-1 1994 OBJECTIVE: To determine CA-125 levels in cervical mucus (CM) during the menstrual cycle and their relationship to gonadal steroids and ovulation. Steroids 122-130 mucin 16, cell surface associated Homo sapiens 24-30 7949628-4 1994 Moreover, other observations seem to support the possibilities that 1) administration of steroids lowers the number of invading CD8-positive cells, 2) induction of MHC-class-I antigens in muscle fibers precedes the inflammatory cell infiltration and that 3) remaining MHC-class-I antigens in muscle fibers may explain the recurrence of myositis often observed in the follow up period. Steroids 89-97 CD8a molecule Homo sapiens 128-131 8038703-4 1994 The antiinflammatory steroids will reduce inflammation-induced prostaglandin synthesis by inhibiting the expression of these two key enzymes, PLA2 and COX-2. Steroids 21-29 phospholipase A2 group IIA Homo sapiens 142-146 7512261-8 1994 Chicken ovalbumin upstream promoter transcription factor (COUP-TF), an orphan member of the steroid/thyroid hormone superfamily, also demonstrated specific binding activity to AFP-RXRE in vitro. Steroids 92-99 alpha fetoprotein Gallus gallus 176-179 8187298-2 1994 The direct role of sex steroids in pubertal bone growth may be an increased GH receptor-coupled GH action. Steroids 23-31 growth hormone receptor Homo sapiens 76-87 8187298-3 1994 We examine the GH-binding protein (GHBP) activity before and after the suppression of female sex steroids and the relation of GHBP to pubertal growth. Steroids 97-105 growth hormone receptor Homo sapiens 35-39 8187298-10 1994 CONCLUSIONS: The high-affinity GHBP is increased by the withdrawal of female sex steroid. Steroids 81-88 growth hormone receptor Homo sapiens 31-35 8184489-3 1994 The role of lipocortin-1 in mediating glucocorticoid-induced effects in these systems has been demonstrated using immunoneutralization strategies and by mimicking steroid actions with highly purified or recombinant lipocortin-1 or its biologically active peptide fragments. Steroids 163-170 annexin A1 Homo sapiens 12-24 8191883-4 1994 Steroid treatment induced a significant increase in HLA-DR and CD19 expression, a significant reduction in CD16+, CD57+, and CD8+ CD57+ cells, and a slight, non-significant, decrease in IL-2 and sIL-2R levels and CD25 expression on CD4+ T lymphocytes. Steroids 0-7 Fc gamma receptor IIIa Homo sapiens 107-111 8191883-4 1994 Steroid treatment induced a significant increase in HLA-DR and CD19 expression, a significant reduction in CD16+, CD57+, and CD8+ CD57+ cells, and a slight, non-significant, decrease in IL-2 and sIL-2R levels and CD25 expression on CD4+ T lymphocytes. Steroids 0-7 CD8a molecule Homo sapiens 125-128 7515872-1 1994 3 alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) [EC 1.1.1.213]2 plays important multifunctional roles in metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins and also in transforming the steroid nucleus for the biosynthesis of bile acids from cholesterol in liver. Steroids 121-137 aldo-keto reductase family 1, member C14 Rattus norvegicus 0-36 7515872-1 1994 3 alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) [EC 1.1.1.213]2 plays important multifunctional roles in metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins and also in transforming the steroid nucleus for the biosynthesis of bile acids from cholesterol in liver. Steroids 121-137 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-49 7515872-1 1994 3 alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) [EC 1.1.1.213]2 plays important multifunctional roles in metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins and also in transforming the steroid nucleus for the biosynthesis of bile acids from cholesterol in liver. Steroids 15-22 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-49 7515872-3 1994 Transfection of the 3 alpha-HSD cDNA in Simian COS7 cells resulted in the expression of an immunoreactive protein to the antibodies against the purified enzyme, and the transfected cells exhibited activities for not only 7 alpha-hydroxy-5 beta-cholestan-3-one, the intermediate of bile acid biosynthesis, but also steroid hormones and 9,10-phenanthrenequinone. Steroids 314-330 aldo-keto reductase family 1, member C14 Rattus norvegicus 20-31 7511155-7 1994 These results suggest that, while substance P, neuropeptide Y, neurotensin and Leu-enkephalin all have the capacity to cause modest increases in the rate of steroid secretion by the zona glomerulosa, these neuropeptides probably do not have a major role in the acute regulation of aldosterone secretion, at least under basal conditions. Steroids 157-164 neurotensin Rattus norvegicus 63-74 8307574-1 1993 The mitochondrial benzodiazepine receptor (mBzR) appears to be a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Steroids 149-164 translocator protein Homo sapiens 4-41 8268313-2 1993 It was found that adrenodoxin reductase stimulates both the 21- and 17 alpha-steroid hydroxylation activities in microsomes of the adrenal cortex with the same efficiency as does NADPH-dependent cytochrome P-450 reductase. Steroids 77-84 ferredoxin reductase Bos taurus 18-39 8262004-4 1993 The current understanding is shaped by the thesis that the concerted central actions of E2 and P are mediated by a host of regulatory peptides produced locally in the hypothalamus, and steroids, in general, augment the production and release of both inhibitory and excitatory peptides in a timely fashion to facilitate the preovulatory LHRH discharge. Steroids 185-193 cystatin 12, pseudogene Homo sapiens 88-96 8242360-0 1993 Up-regulation of androgen receptor immunoreactivity in the rat brain by androgenic-anabolic steroids. Steroids 92-100 androgen receptor Rattus norvegicus 17-34 8242360-5 1993 The simultaneous androgen receptor up-regulation in these regions by AAS may account for the complex anabolic steroid abuse syndrome. Steroids 110-117 androgen receptor Rattus norvegicus 17-34 8360152-2 1993 The substrate steroid substantially protects 3 beta-HSD activity from inactivation by 2 alpha-BAP. Steroids 14-21 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 45-55 30169894-9 2018 In conclusion, we demonstrate that FKBP51 has the potential to control inflammation in steroid insensitive patients in a steroid-dependent and independent manner and thus may be worthy of further study as a drug target. Steroids 121-128 FK506 binding protein 5 Mus musculus 35-41 30291224-2 2018 IL-17A regulates airway inflammation, oxidative stress, and reduction of steroid sensitivity in chronic obstructive pulmonary disease (COPD). Steroids 73-80 interleukin 17A Homo sapiens 0-6 8346925-3 1993 Furthermore, it has been shown that the plasma isozyme of PAF-AH is regulated by various steroid hormone. Steroids 89-104 PCNA clamp associated factor Rattus norvegicus 58-61 29990494-5 2018 Sex-steroid-related transcription (i.e., steroid 5alpha-reductase type 2 (srd5alpha2) and eralpha) and production (i.e., 5alpha-DHT) were also differentially regulated by THs. Steroids 4-11 steroid 5 alpha-reductase 2 Xenopus tropicalis 41-72 8257089-1 1993 The retinoid X receptor alpha is one of a number of retinoic acid receptors which are members of the steroid/thyroid hormone superfamily. Steroids 101-108 retinoid X receptor alpha Homo sapiens 4-29 29990494-5 2018 Sex-steroid-related transcription (i.e., steroid 5alpha-reductase type 2 (srd5alpha2) and eralpha) and production (i.e., 5alpha-DHT) were also differentially regulated by THs. Steroids 4-11 steroid 5 alpha-reductase 2 Xenopus tropicalis 74-84 8325932-4 1993 Analysis of coding sequences of the androgen receptor gene revealed a single nucleotide substitution in exon E, resulting in an amino acid change from glycine (GGG) to valine (GTG) at amino acid 743 within the steroid binding domain of AR. Steroids 210-217 gamma-glutamyltransferase 1 Homo sapiens 176-179 8228970-1 1993 The effect of castration and steroid replacement on the intracellular partitioning of the androgen receptor in the brain of the male Syrian hamster was determined using immunocytochemistry. Steroids 29-36 androgen receptor Mesocricetus auratus 90-107 30298667-5 2018 Calcineurin inhibitor and cyclophosphamide are recommended in steroid-dependent/steroid-resistant patients. Steroids 62-69 calcineurin binding protein 1 Homo sapiens 0-21 30298667-5 2018 Calcineurin inhibitor and cyclophosphamide are recommended in steroid-dependent/steroid-resistant patients. Steroids 80-87 calcineurin binding protein 1 Homo sapiens 0-21 29852923-3 2018 Thus, we examined the molecular mechanisms of DAF expression regulation by ovarian steroid hormones in the mouse uterus. Steroids 83-99 CD55 molecule, decay accelerating factor for complement Mus musculus 46-49 8325594-8 1993 Steroid treatment may suppress fecal ECP excretion. Steroids 0-7 ribonuclease A family member 3 Homo sapiens 37-40 8510182-5 1993 Samples taken 20-40 min after the steroid treatment demonstrated pyramidal cells expressing GR IR in both the cytoplasmic and nuclear pools. Steroids 34-41 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 92-94 29853649-12 2018 As IL-33 is implicated in steroid-refractory severe asthma, our findings on the effects of IDR-1002 may contribute to the development of novel therapies for steroid-refractory severe asthma. Steroids 26-33 interleukin 33 Mus musculus 3-8 8455948-1 1993 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes that encode nuclear receptors for various hydrophobic ligands such as steroids, retinoic acid and thyroid hormones. Steroids 158-166 thyroid hormone receptor alpha Homo sapiens 4-34 29944893-0 2018 Methamphetamine alters DNMT and HDAC activity in the posterior dorsal medial amygdala in an ovarian steroid-dependent manner. Steroids 100-107 DNA methyltransferase 1 Homo sapiens 23-27 8455948-1 1993 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes that encode nuclear receptors for various hydrophobic ligands such as steroids, retinoic acid and thyroid hormones. Steroids 158-166 thyroid hormone receptor alpha Homo sapiens 36-40 8460940-17 1993 The stimulation of PAF-AH secretion during differentiation of HL-60 cells and its modulation by LPS and steroid hormones may provide a useful model system for studying PAF metabolism during the inflammatory response and pregnancy. Steroids 104-120 phospholipase A2 group VII Homo sapiens 19-25 29944893-0 2018 Methamphetamine alters DNMT and HDAC activity in the posterior dorsal medial amygdala in an ovarian steroid-dependent manner. Steroids 100-107 histone deacetylase 9 Homo sapiens 32-36 8498893-0 1993 Clinical effects of complex spa therapy on patients with steroid-dependent intractable asthma (SDIA). Steroids 57-64 surfactant protein A2 Homo sapiens 28-31 29944893-8 2018 Our results show that methamphetamine alters DNMT and HDAC activity in the MePD in an ovarian steroid-dependent fashion. Steroids 94-101 DNA methyltransferase 1 Homo sapiens 45-49 29944893-8 2018 Our results show that methamphetamine alters DNMT and HDAC activity in the MePD in an ovarian steroid-dependent fashion. Steroids 94-101 histone deacetylase 9 Homo sapiens 54-58 29684479-1 2018 Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 41-46 8440186-8 1993 The compartmentalization of two strictly correlated enzymes (5 alpha-reductase and 3 alpha-hydroxysteroid dehydrogenase) in separate central nervous system cell populations suggests the simultaneous participation of neurons and glial cells in the 5 alpha-reductive metabolism of testosterone and possibly other hormonal steroids (e.g. progesterone, corticoids, etc. Steroids 320-328 aldo-keto reductase family 1, member C14 Rattus norvegicus 83-119 8444412-9 1993 The mitochondrial fraction also catalyzed the oxidation of the 27-hydroxy group and contained a 3 beta-hydroxy-delta 5-steroid dehydrogenase active on 7 alpha-hydroxylated C27-steroids. Steroids 176-184 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 96-140 29684479-5 2018 Exposure of these cells for 24 h to 1 muM DHEAS also leads to a significant reduction of claudin-1 expression that cannot be prevented by high concentrations of the steroid sulfatase inhibitor STX64, indicating that desulfation and further conversion of DHEAS to some other steroid hormone is not required for this action. Steroids 274-289 sulfotransferase family 2A member 1 Homo sapiens 42-47 30086355-3 2018 Docking analysis of 1 revealed that it might bind to the ligand binding domain (LBD) of PPARgamma in a manner similar to that of the synthetic steroid mifepristone (7), which is used clinically to treat hypercortisolism and was recently reported to be a PPARgamma agonist. Steroids 143-150 peroxisome proliferator-activated receptor gamma Rattus norvegicus 88-97 8482012-0 1993 Regulation of two different hsp70 transcript populations in steroid hormone-induced fungal development. Steroids 60-75 heat shock protein family A (Hsp70) member 4 Homo sapiens 28-33 29501539-8 2018 In SLE patients, both hyperhomocysteinemia and MTHFR 677TT genotype were identified as independent contributors for plaque formation, following adjustment for traditional cardiovascular risk factors and disease related features, including age, sex, BMI, cholesterol and triglyceride levels, presence of arterial hypertension, smoking (pack/years), disease duration and total steroid dose [OR 95% (CI): 5.8 (1.0-35.8) and 5.2 (1.1-24.0), respectively]. Steroids 375-382 methylenetetrahydrofolate reductase Homo sapiens 47-52 8482993-1 1993 A clinical and electrophysiological study evaluated the usefulness of local steroid therapy for carpal tunnel syndrome (CTS). Steroids 76-83 transthyretin Homo sapiens 120-123 8482993-7 1993 In order to appraise the long-term effect of local steroid treatment on CTS, 53 patients (91 nerves) were studied and followed up by means of clinical and electrophysiological examinations performed every 2 months for 2 years. Steroids 51-58 transthyretin Homo sapiens 72-75 8446105-2 1993 The DNA- and steroid-binding domains of the rat androgen receptor [glutathione-S-transferase (GST)-AR1] and the DNA-binding domain and hinge region alone (GST-AR2) were expressed in Escherichia coli as isopropyl-B-D-thioglactopyranoside-induced fusion proteins with GST and purified using glutathione affinity chromatography. Steroids 13-20 androgen receptor Rattus norvegicus 48-65 29964007-7 2018 In this review, we describe several notable characteristics of GPER1 such as the ability of several endogenous steroids as well as artificially synthesized molecules to bind the GPER1. Steroids 111-119 G protein-coupled estrogen receptor 1 Homo sapiens 63-68 1336364-3 1992 Treatment of AtT20 D16:16 cells with the synthetic glucocorticoid dexamethasone markedly (up to 10-fold) increased the level of a single (approximately 1.6kb) calmodulin mRNA 90 min after the application of steroid. Steroids 207-214 calmodulin 2 Mus musculus 159-169 1336364-6 1992 Corticotropin releasing factor, added for 30 min at the start of steroid treatment, prevented the increase of calmodulin mRNA, as well as the suppression of corticotropin releasing factor-evoked ACTH release caused by dexamethasone. Steroids 65-72 corticotropin releasing hormone Mus musculus 0-30 1336364-6 1992 Corticotropin releasing factor, added for 30 min at the start of steroid treatment, prevented the increase of calmodulin mRNA, as well as the suppression of corticotropin releasing factor-evoked ACTH release caused by dexamethasone. Steroids 65-72 calmodulin 2 Mus musculus 110-120 22217854-8 1992 These results indicate that key steroid-biosynthetic enzymes, such as 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase, 17beta- and 20alpha-hydroxysteroid dehydrogenases and steroid 17alpha-monooxygenase/17,20-lyase are also expressed extraglandularly in the rat. Steroids 32-39 aldo-keto reductase family 1, member C12 Rattus norvegicus 130-179 29964007-7 2018 In this review, we describe several notable characteristics of GPER1 such as the ability of several endogenous steroids as well as artificially synthesized molecules to bind the GPER1. Steroids 111-119 G protein-coupled estrogen receptor 1 Homo sapiens 178-183 29956754-7 2018 Furthermore, patients with steroid-resistant AR exhibited significantly increased urinary CXCL13/Cr levels than patients with reversible AR (P=0.001). Steroids 27-34 C-X-C motif chemokine ligand 13 Homo sapiens 90-96 1281559-10 1992 The appearance of a high preponderance of CD8CD57 cells in the renal allograft at the time of a rejection crisis may constitute a particularly severe prognostic sign regarding the reversibility of the response after treatment with steroids and/or monoclonal antibodies. Steroids 231-239 CD8a molecule Homo sapiens 42-45 29956754-10 2018 In addition, high urinary CXCL13/Cr levels predicted a poor response to steroid treatment and compromised graft function. Steroids 72-79 C-X-C motif chemokine ligand 13 Homo sapiens 26-32 29796946-7 2018 GA3 enhanced production of sesquiterpenoids, polyterpenoids, steroids and monoterpenoids compared to MS0 and BA, and also seemed to positively influence the MEP/DOXP and MVA pathways. Steroids 61-69 succinyl-CoA:glutarate-CoA transferase Homo sapiens 0-3 1425418-14 1992 This occurs as a direct result of the enhanced expression of SCP2, P450scc, adrenodoxin and adrenodoxin reductase, proteins specifically required to transport and process cholesterol for steroid production in the large luteal cell. Steroids 187-194 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 67-74 29986752-4 2018 We report a case of adult onset Still"s disease in an older patient successfully treated with steroids in which interleukin-18 was a useful marker of disease activity. Steroids 94-102 interleukin 18 Homo sapiens 112-126 1430084-12 1992 These data provide good indirect evidence for coregulation of the GH-BP with both sex steroids and gonadotropins. Steroids 86-94 growth hormone receptor Homo sapiens 66-71 29788357-5 2018 Dhh/Ihh DKO female mice were infertile because of a lack of theca cells and their steroid product androgen. Steroids 82-89 Indian hedgehog Mus musculus 4-7 1401999-1 1992 Three beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) catalyses an obligatory step in the biosynthesis of all classes of hormonal steroids, namely, the oxidation/isomerization of 3 beta-hydroxy-5-ene steroids into the corresponding 3-keto-4-ene steroids in gonadal as well as in peripheral tissues. Steroids 155-163 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-77 1390295-3 1992 Knowing the crucial role of 3 beta-HSD and 17 beta-HSD in sex steroid biosynthesis both in classical as well as in peripheral steroidogenic tissues, we have concentrated our efforts on the elucidation of the molecular structure of these enzyme families. Steroids 62-69 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 28-38 29219195-3 2018 We recently demonstrated that, NGB functions as a compensatory protein of the steroid hormone 17beta-estradiol (E2) protecting cancer cells against the apoptotic death induced by oxidative stress. Steroids 78-93 neuroglobin Homo sapiens 31-34 1279864-5 1992 In rats, brain SGP-2 is regulated by gonadal and adrenal steroids. Steroids 57-65 clusterin Rattus norvegicus 15-20 29545329-5 2018 A previously validated algorithm of 2 MAGIC biomarkers (ST2 and REG3alpha) consistently separated steroid-resistant patients into 2 groups with dramatically different NRM and OS (P < .001 for all 3 cohorts). Steroids 98-105 ST2 Homo sapiens 56-59 1527603-5 1992 Removal of circulating adrenal steroids resulted in a greater density of both GFAP-immunoreactive and vimentin-immunoreactive cells compared to sham-operated animals; CORT replacement prevented increases in both of these cell types. Steroids 31-39 glial fibrillary acidic protein Rattus norvegicus 78-82 29721586-0 2018 Corticosteroid-binding globulin, induced in testicular Leydig cells by perfluorooctanoic acid, promotes steroid hormone synthesis. Steroids 104-119 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 0-31 1511313-0 1992 Regulation of glucocorticoid receptor immunoreactivity in the rat hippocampus by androgenic-anabolic steroids. Steroids 101-109 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 14-37 1572282-0 1992 Steroid regulation of the synthesis and secretion of retinol-binding protein by the uterus of the pig. Steroids 0-7 retinol binding protein 4 Sus scrofa 53-76 29721586-3 2018 Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Steroids 114-122 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 0-31 29721586-3 2018 Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Steroids 114-122 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 33-36 1582424-2 1992 Here we show that SalF7L encodes an active 3 beta-HSD, by the conversion of pregnenolone to the steroid hormone progesterone. Steroids 96-111 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 43-53 29721586-8 2018 Thus, the influence of PFOA on blood CBG may change free steroid hormone concentrations, thereby serving as an endocrine disruptor. Steroids 57-72 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 37-40 29401623-7 2018 We also showed that the Sertoli cell-expressed HSD17B1 participates in testicular steroid synthesis, evidenced by a compensatory up-regulation of HSD17B3 in Leydig cells. Steroids 82-89 hydroxysteroid (17-beta) dehydrogenase 1 Mus musculus 47-54 1356900-10 1992 Whether NG-TRA and/or other MDR-related transporters are involved in the transport of steroids, peptide hormones or growth factors remains to be established. Steroids 86-94 T cell receptor alpha locus Homo sapiens 11-14 1409837-0 1992 Modulation of adenosine deaminase activity of endothelial cells by steroids. Steroids 67-75 adenosine deaminase Homo sapiens 14-33 29771985-8 2018 In docking, Fel d 1-ABP dimers exhibit the maximum surface binding ability of AG compared with that of AB dimers and the several polar interactions between ABP dimers with steroids. Steroids 172-180 secretoglobin, family 1B, member 27 Mus musculus 20-23 1312440-2 1992 This study was designed to determine whether BK acts on adrenocortical cells to stimulate steroid secretion. Steroids 90-97 kininogen 1 Bos taurus 45-47 29771985-8 2018 In docking, Fel d 1-ABP dimers exhibit the maximum surface binding ability of AG compared with that of AB dimers and the several polar interactions between ABP dimers with steroids. Steroids 172-180 secretoglobin, family 1B, member 27 Mus musculus 156-159 29771985-10 2018 These findings suggest that the biological and molecular function of Fel d 1 is similar to that of ABP in chemical communication, possibly via pheromone and/or steroid binding. Steroids 160-167 secretoglobin, family 1B, member 27 Mus musculus 99-102 1569919-2 1992 DHEA-ST has a subunit molecular mass of 35 kDa and is responsible for the majority of the sulfation of steroids and bile acids in the liver. Steroids 103-111 sulfotransferase family 2A member 1 Homo sapiens 0-7 1569919-11 1992 Adrenal DHEA-ST demonstrated the same pattern of reactivity towards different steroid substrates as did human liver DHEA-ST, and neither form of DHEA-ST was found to sulfate cortisol. Steroids 78-85 sulfotransferase family 2A member 1 Homo sapiens 8-15 1569919-12 1992 The results of this study suggest that DHEA-ST is the major steroid ST present in human liver and adrenal tissue and that the physical, biochemical, and kinetic properties of adrenal DHEA-ST are similar if not identical to those of the liver form of the enzyme. Steroids 60-67 sulfotransferase family 2A member 1 Homo sapiens 39-46 28743544-1 2018 The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. Steroids 145-153 solute carrier family 10 member 6 Homo sapiens 4-46 28743544-1 2018 The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. Steroids 145-153 solute carrier family 10 member 6 Homo sapiens 47-51 28743544-1 2018 The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. Steroids 145-153 solute carrier family 10 member 6 Homo sapiens 63-70 1373297-0 1992 Steroids inversely affect the biosynthesis and secretion of human prostatic acid phosphatase and prostate-specific antigen in the LNCaP cell line. Steroids 0-8 acid phosphatase 3 Homo sapiens 66-92 28743544-1 2018 The sodium-dependent organic anion transporter SOAT (gene name SLC10A6 in man and Slc10a6 in mice) is a plasma membrane transporter for sulfated steroids, which is highly expressed in germ cells of the testis. Steroids 145-153 solute carrier family 10 member 6 Homo sapiens 82-89 1373297-1 1992 In order to elucidate the mechanism of androgen-regulation of genes expressed only in the prostate gland, the effects of steroid hormones on the biosynthesis and secretion of human prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) were studied in the human prostatic carcinoma cell line, LNCaP. Steroids 121-128 acid phosphatase 3 Homo sapiens 181-207 1373297-1 1992 In order to elucidate the mechanism of androgen-regulation of genes expressed only in the prostate gland, the effects of steroid hormones on the biosynthesis and secretion of human prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) were studied in the human prostatic carcinoma cell line, LNCaP. Steroids 121-128 acid phosphatase 3 Homo sapiens 209-212 1373297-9 1992 Other steroids could elicit effects on PAP and PSA biosynthesis similar to those induced by R1881, and the combined effects of effective concentrations of these steroids were undistinguishable from those caused by each one of them separately, suggesting that all these compounds compete for binding to the same modified androgen receptors of the LNCaP cells. Steroids 6-14 acid phosphatase 3 Homo sapiens 39-42 29755357-1 2018 Lipocalin 2 (LCN2) is a highly conserved secreted adipokine acting as a serum transport protein for small hydrophobic molecules such as fatty acids and steroids. Steroids 152-160 lipocalin 2 Homo sapiens 0-11 1373297-11 1992 The fact that the changes observed at the protein level were accompanied by increased levels of PSA mRNAs and by decreased levels of PAP mRNA in steroid-treated cells, suggests that one of the targets of androgen and steroid action in the regulation of these genes is at the mRNA level. Steroids 145-152 acid phosphatase 3 Homo sapiens 133-136 1373297-11 1992 The fact that the changes observed at the protein level were accompanied by increased levels of PSA mRNAs and by decreased levels of PAP mRNA in steroid-treated cells, suggests that one of the targets of androgen and steroid action in the regulation of these genes is at the mRNA level. Steroids 217-224 acid phosphatase 3 Homo sapiens 133-136 1562516-1 1992 The enzyme 3 beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase (3 beta-HSD) catalyzes the oxidation and isomerization of 5-ene-3 beta-hydroxypregnene and 5-ene-hydroxyandrostene steroid precursors into the corresponding 4-ene-ketosteroids necessary for the formation of all classes of steroid hormones. Steroids 291-307 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 70-80 1510825-8 1992 The changes in c-fos and (or) c-myc gene expression in the uterus and nonreproductive organs could be due to sexual steroids and (or) systemic factors from uterine cells or blastocysts. Steroids 116-124 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 15-20 1510828-2 1992 Since C19 steroids with an oxygen function at C11 have not been recorded as products of steroid biosynthesis in normal mammalian testes, we have examined their possible production in purified preparations of porcine Leydig cells. Steroids 10-18 RNA polymerase III subunit K Homo sapiens 46-49 1510828-2 1992 Since C19 steroids with an oxygen function at C11 have not been recorded as products of steroid biosynthesis in normal mammalian testes, we have examined their possible production in purified preparations of porcine Leydig cells. Steroids 10-17 RNA polymerase III subunit K Homo sapiens 46-49 29755357-1 2018 Lipocalin 2 (LCN2) is a highly conserved secreted adipokine acting as a serum transport protein for small hydrophobic molecules such as fatty acids and steroids. Steroids 152-160 lipocalin 2 Homo sapiens 13-17 29740398-4 2018 From the data of the hippocampus of adult male rats, hippocampal principal neurons [pyramidal cells in CA1-CA3 and granule cells in dentate gyrus (DG)] have a complete system for biosynthesis of sex steroids. Steroids 199-207 carbonic anhydrase 3 Rattus norvegicus 107-110 1620284-1 1992 Previous studies have shown that the hypothalamic concentrations of beta-endorphin (beta-EP) and other proopiomelanocortin (POMC)-derived peptides change in the female rat following castration and gonadal steroid replacement. Steroids 205-212 proopiomelanocortin Rattus norvegicus 103-122 1620284-1 1992 Previous studies have shown that the hypothalamic concentrations of beta-endorphin (beta-EP) and other proopiomelanocortin (POMC)-derived peptides change in the female rat following castration and gonadal steroid replacement. Steroids 205-212 proopiomelanocortin Rattus norvegicus 124-128 30701852-8 2018 The highest content of the Il-17 was registered at patients with bronchial asthma and obesity as in comparison with indicators of patients with normal BMI, and with almost healthy that, perhaps, is the reason of low effect of steroid therapy at these patients. Steroids 226-233 interleukin 17A Homo sapiens 27-32 1576689-0 1992 Use of the thermostable glucose-6-phosphate dehydrogenase as a label enzyme in steroid enzyme immunoassays. Steroids 79-86 glucose-6-phosphate dehydrogenase Homo sapiens 24-57 1548863-7 1992 CSFP did not change significantly from its baseline value while the aorta was cross-clamped in gp 1; CSFP was significantly reduced to 6.2 mm Hg in gp 2, steroid-treated animals (P less than 0.05 vs gp 1); a further significant reduction in CSFP was noted in gp 3 and 4 undergoing CSFD (0.07 and 0.67 mm Hg, respectively, P less than 0.05 vs gp 1 and 2). Steroids 154-161 glycoprotein 2 Canis lupus familiaris 342-352 30045005-9 2018 Results indicate that: a) the primary mechanism triggering steroid atrophy is an early transient activation of Murf-1; b) uAG inhibits Murf-1 induction counteracting steroid atrophy. Steroids 59-66 tripartite motif-containing 63 Mus musculus 111-117 1660470-10 1991 These studies suggest that high affinity association of the VDR with DNA requires both the DNA-binding domain as well as an additional independent structure located within the steroid-binding region. Steroids 176-183 vitamin D receptor Homo sapiens 60-63 1954914-2 1991 Steroid hormones and paracrine acting factors such as oxytocin (OXT) and angiotensin II (AII) diffuse from ovarian tissue into the fluid, which is pumped through the MDS and collected in fractions. Steroids 0-16 oxytocin/neurophysin I prepropeptide Homo sapiens 54-62 1954914-2 1991 Steroid hormones and paracrine acting factors such as oxytocin (OXT) and angiotensin II (AII) diffuse from ovarian tissue into the fluid, which is pumped through the MDS and collected in fractions. Steroids 0-16 oxytocin/neurophysin I prepropeptide Homo sapiens 64-67 30045005-9 2018 Results indicate that: a) the primary mechanism triggering steroid atrophy is an early transient activation of Murf-1; b) uAG inhibits Murf-1 induction counteracting steroid atrophy. Steroids 166-173 tripartite motif-containing 63 Mus musculus 135-141 29409762-9 2018 This indicated that the decrease in steroids downstream from 3beta-HSD following PMZ and CT exposure induced a compensatory autocrine response in 3beta-HSD gene expression. Steroids 36-44 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 61-70 29409762-9 2018 This indicated that the decrease in steroids downstream from 3beta-HSD following PMZ and CT exposure induced a compensatory autocrine response in 3beta-HSD gene expression. Steroids 36-44 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 146-155 29511094-4 2018 The involvement of TSPO in the steroid biosynthesis has been suggested by 30 years of researches, using biochemical, pharmacological and genetic experimental approaches. Steroids 31-38 translocator protein Homo sapiens 19-23 1666369-3 1991 We show here that the steroids (0.1-100 microM) allotetrahydrocorticosterone (THCC), dehydroepiandrosterone sulfate (DHEAS) and pregnanolone can rapidly and reversibly depress voltage-gated calcium currents in freshly isolated adult hippocampal CA1 pyramidal neurons. Steroids 22-30 carbonic anhydrase 1 Homo sapiens 245-248 29511094-6 2018 Using in vivo genetic manipulations aimed at deleting TSPO, some researchers have excluded its role in steroid production. Steroids 103-110 translocator protein Homo sapiens 54-58 1790169-1 1991 The conjugates of glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase with progesterone and cortisol, containing 1-40 steroid molecules per enzyme molecule, were obtained by the reactions of N-succinimide esters of the 3-[O-(carboxymethyl)oximes)] of cortisol and progesterone with a protein in a water-DMFA (10%) medium. Steroids 149-156 glucose-6-phosphate dehydrogenase Homo sapiens 18-51 1790169-1 1991 The conjugates of glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and malate dehydrogenase with progesterone and cortisol, containing 1-40 steroid molecules per enzyme molecule, were obtained by the reactions of N-succinimide esters of the 3-[O-(carboxymethyl)oximes)] of cortisol and progesterone with a protein in a water-DMFA (10%) medium. Steroids 149-156 malic enzyme 1 Homo sapiens 80-100 29511094-10 2018 about "TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis" are part of this debate and provide further and more accurate information supporting the importance of TSPO as a steroidogenesis regulator. Steroids 74-81 translocator protein Homo sapiens 196-200 29402637-2 2018 Clearance of steroids occurs primarily in hepatic tissues, however, it was discovered that there is an abundant activity of the phase II steroid metabolizing enzyme UDP-glucuronosyltransferase (UGT) in uterine biopsies. Steroids 13-21 solute carrier family 35 member A2 Bos taurus 165-192 1909872-1 1991 The UDP glucuronosyltransferase gene UGT2B2 is constitutively expressed in rat liver, and the enzyme has been shown to conjugate glucuronic acid with various endogenous steroids, especially etiocholanolone and androsterone. Steroids 169-177 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 4-31 1909872-1 1991 The UDP glucuronosyltransferase gene UGT2B2 is constitutively expressed in rat liver, and the enzyme has been shown to conjugate glucuronic acid with various endogenous steroids, especially etiocholanolone and androsterone. Steroids 169-177 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 37-43 29402637-2 2018 Clearance of steroids occurs primarily in hepatic tissues, however, it was discovered that there is an abundant activity of the phase II steroid metabolizing enzyme UDP-glucuronosyltransferase (UGT) in uterine biopsies. Steroids 13-21 solute carrier family 35 member A2 Bos taurus 194-197 29402637-2 2018 Clearance of steroids occurs primarily in hepatic tissues, however, it was discovered that there is an abundant activity of the phase II steroid metabolizing enzyme UDP-glucuronosyltransferase (UGT) in uterine biopsies. Steroids 13-20 solute carrier family 35 member A2 Bos taurus 165-192 29402637-2 2018 Clearance of steroids occurs primarily in hepatic tissues, however, it was discovered that there is an abundant activity of the phase II steroid metabolizing enzyme UDP-glucuronosyltransferase (UGT) in uterine biopsies. Steroids 13-20 solute carrier family 35 member A2 Bos taurus 194-197 1677678-4 1991 The effects of long-term CORT and ADX on GFAP in hippocampus and cortex were also seen in striatum, midbrain, and cerebellum, findings suggestive of brain-wide adrenal steroid regulation of this astrocyte protein. Steroids 168-175 glial fibrillary acidic protein Rattus norvegicus 41-45 1677678-5 1991 The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. Steroids 164-172 glial fibrillary acidic protein Rattus norvegicus 15-19 29361571-0 2018 Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling. Steroids 129-136 mir-125 stem loop Drosophila melanogaster 85-92 1677678-5 1991 The changes in GFAP amount due to CORT and ADX were paralleled by changes in GFAP mRNA, indicating a possible transcriptional or at least genomic effect of adrenal steroids. Steroids 164-172 glial fibrillary acidic protein Rattus norvegicus 77-81 1677678-7 1991 The negative regulation of GFAP and GFAP mRNA by adrenal steroids suggested that increases in GFAP that result from brain injury may be attenuated by glucocorticoids. Steroids 57-65 glial fibrillary acidic protein Rattus norvegicus 27-31 1677678-7 1991 The negative regulation of GFAP and GFAP mRNA by adrenal steroids suggested that increases in GFAP that result from brain injury may be attenuated by glucocorticoids. Steroids 57-65 glial fibrillary acidic protein Rattus norvegicus 36-40 1677678-7 1991 The negative regulation of GFAP and GFAP mRNA by adrenal steroids suggested that increases in GFAP that result from brain injury may be attenuated by glucocorticoids. Steroids 57-65 glial fibrillary acidic protein Rattus norvegicus 36-40 29361571-3 2018 This is controlled via steroid-induced miR-125, which targets a negative regulator of Notch signaling, Tom. Steroids 23-30 mir-125 stem loop Drosophila melanogaster 39-46 29361571-4 2018 Thus, miR-125 acts as a spatiotemporal coordinator between paracrine Notch and endocrine steroid signaling. Steroids 89-96 mir-125 stem loop Drosophila melanogaster 6-13 1652443-5 1991 This down-regulation was not affected by aminoglutethimide, an inhibitor of the cholesterol-side-chain-cleavage enzyme (cytochrome P-450scc) which is the rate-limiting step in the biosynthesis of steroids. Steroids 196-204 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 120-139 29368155-6 2018 SMILE (steroid, methotrexate, ifosfamide, L-asparaginase, and etoposide) or other L-asparaginase-containing therapy is promising for advanced-stage ENKL, followed by either autologous or allogeneic hematopoietic stem cell transplantation. Steroids 7-14 transmembrane O-mannosyltransferase targeting cadherins 3 Homo sapiens 0-5 1922009-11 1991 Results of our study demonstrate that calf uterine PR is represented by a major steroid binding protein of 114 kDa that exists in association with hsp-90. Steroids 80-87 progesterone receptor Bos taurus 51-53 2059213-4 1991 Among sex steroids only progesterone increased significantly 15-PGDH activity. Steroids 10-18 carbonyl reductase 1 Homo sapiens 61-68 29607238-3 2018 We report a case of secondary PAP in a 47-year-old man, whose risk factors include occupational exposure to inhaled toxins, especially aluminum dust, the use of anabolic steroids, and alcohol abuse, which in mice leads to alveolar macrophage dysfunction through a zinc-dependent mechanism that inhibits granulocyte macrophage-colony stimulating factor (GM-CSF) receptor signalling. Steroids 170-178 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 303-351 29351807-0 2018 Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids. Steroids 109-117 vitamin D receptor Homo sapiens 0-18 29101097-1 2018 The constitutive androstane receptor (CAR) is a nuclear receptor that acts as a transcription factor for a variety of genes, including genes encoding xenobiotic, steroid, and drug-metabolizing enzymes and transporters. Steroids 162-169 nuclear receptor subfamily 1 group I member 3 Homo sapiens 4-36 2039516-1 1991 We have recently described a 16 kDa steroid binding core (Thr537-Arg673) of the rat glucocorticoid receptor [Simons et al. Steroids 36-43 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 84-107 1719019-4 1991 In the presence of E2 and P, a 10- to 15-fold increase in IGFBP-2 was detected in the conditioned medium beginning after about 7 days in culture, when cells decidualized and steroid-mediated prolactin secretion began. Steroids 174-181 cystatin 12, pseudogene Homo sapiens 19-27 29101097-1 2018 The constitutive androstane receptor (CAR) is a nuclear receptor that acts as a transcription factor for a variety of genes, including genes encoding xenobiotic, steroid, and drug-metabolizing enzymes and transporters. Steroids 162-169 nuclear receptor subfamily 1 group I member 3 Homo sapiens 38-41 29333723-3 2018 Nandrolone, an anabolic steroid, upregulates both MyoD and Numb expression in myogenic cells. Steroids 24-31 NUMB endocytic adaptor protein Homo sapiens 59-63 2018483-1 1991 The nucleic acid sequence of the androgen receptor (AR) gene predicts that the protein structure possesses DNA- and steroid-binding domains that show high degrees of sequence similarity with those of other steroid receptors. Steroids 116-123 androgen receptor Canis lupus familiaris 33-50 2018483-1 1991 The nucleic acid sequence of the androgen receptor (AR) gene predicts that the protein structure possesses DNA- and steroid-binding domains that show high degrees of sequence similarity with those of other steroid receptors. Steroids 116-123 androgen receptor Canis lupus familiaris 52-54 2018483-2 1991 Since the steroid-binding domain of the AR corresponds to a 30 kDa portion of the protein, and the AR structure may be monomeric or hetero-oligomeric depending on its transformation state, we have herein determined the AR radiation-inactivation size (RIS) in relation to the molecular structure whose binding activity toward methyltrienolone (R1881) is abolished by a radiation "hit". Steroids 10-17 androgen receptor Canis lupus familiaris 40-42 28707553-6 2018 Ziram competitively inhibited SRD5A1 and non-competitively inhibited AKR1C14 when steroid substrates were used. Steroids 82-89 aldo-keto reductase family 1, member C14 Rattus norvegicus 69-76 30056903-4 2018 MATERIALS AND METHODS: The level of serum endocan among 63 kidney transplant recipients on three immunosuppressives (calcineurin inhibitors, mycophenolate mofetil, steroids) in correlation with other markers of endothelial damage was estimated. Steroids 164-172 endothelial cell specific molecule 1 Homo sapiens 42-49 2031863-11 1991 In the presence of NADPH, after 5 h incubation only 30.5 +/- 14.6% (mean +/- SD) of steroid present was norgestimate. Steroids 84-91 2,4-dienoyl-CoA reductase 1 Homo sapiens 19-24 1847589-2 1991 The staining was dramatically affected by subacute treatment with ovarian steroids: epithelial cells were predominantly positive in immature rabbits, whereas, in sex steroid-primed rabbits, ET-1 was mainly localized in the stromal compartment. Steroids 74-81 endothelin-1 Oryctolagus cuniculus 190-194 29552620-0 2018 Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn"s Disease. Steroids 37-45 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 28-33 1829436-3 1991 Patients receiving steroids had low frequencies of CD29+CD4+ cells. Steroids 19-27 integrin subunit beta 1 Homo sapiens 51-55 1987520-6 1991 The role of zidovudine and of steroids in the management of LIP remains to be determined. Steroids 30-38 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 60-63 29552620-10 2018 Steroids and pirfenidone induced Ca2+ influx in InMyoFibs, which was antagonized by the selective TRPA1 channel blocker HC-030031. Steroids 0-8 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 98-103 28938470-11 2017 Furthermore, Cyp21a2-deficient larvae had a typical steroid profile, with reduced concentrations of cortisol and increased concentrations of 17-hydroxyprogesterone and 21-deoxycortisol. Steroids 52-59 cytochrome P450, family 21, subfamily A, polypeptide 2 Danio rerio 13-20 1679008-2 1991 Transfectants expressed beta 2-ARs that were able to stimulate adenylyl cyclase activity and steroid biosynthesis. Steroids 93-100 hemoglobin, beta adult minor chain Mus musculus 24-30 29078090-0 2017 Swertiamarin, a natural steroid, prevent bone erosion by modulating RANKL/RANK/OPG signaling. Steroids 24-31 TNF superfamily member 11 Homo sapiens 68-73 1846095-12 1991 However, because the different stabilities of 3 beta HSD and hydroxylase proteins and/or mRNAs may play a critical role in determining the zone-specific steroids secreted from the adrenal cortex, other cAMP-dependent or independent regulatory mechanisms may also be important in regulating the expression of adrenal 3 beta HSD. Steroids 153-161 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 46-56 1668831-5 1991 Levels of steroid binding varied between 38 and 890 fmol/mg protein for progesterone receptor, and between 22 and 94 fmol/mg protein for estrogen receptor. Steroids 10-17 progesterone receptor Bos taurus 72-93 28990653-3 2017 Our objective was to evaluate the in-vitro metabolic interaction between paritaprevir and the oral contraceptive steroid ethinyl estradiol (EE), a UGT 1A1 substrate. Steroids 113-120 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 147-154 2285587-10 1990 Steroid-deprived T-47-D cells acquire sensitivity to stimulation by TGF beta and have raised TGF beta 1 and TGF beta 2 mRNA levels. Steroids 0-7 transforming growth factor beta 2 Homo sapiens 108-118 29074640-0 2017 TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Steroids 67-74 translocator protein Rattus norvegicus 0-4 2174914-4 1990 We have previously shown that cells from three affected children in this group contain an "ochre" nonsense mutation coding for a premature stop codon in exon 7 within the steroid-binding domain of the VDR gene. Steroids 171-178 vitamin D receptor Homo sapiens 201-204 29074640-1 2017 The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and apoptosis. Steroids 162-177 translocator protein Rattus norvegicus 33-37 2174914-12 1990 In summary, our data show that the genetic abnormality is a point mutation within the steroid-binding domain of the VDR in all seven related families with HVDRR. Steroids 86-93 vitamin D receptor Homo sapiens 116-119 29074640-2 2017 TSPO binds with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into mitochondria, which is the rate-limiting step in steroid formation. Steroids 100-107 translocator protein Rattus norvegicus 0-4 29074640-2 2017 TSPO binds with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into mitochondria, which is the rate-limiting step in steroid formation. Steroids 216-223 translocator protein Rattus norvegicus 0-4 29074640-7 2017 These results also support a role for TSPO ligands in diseases with steroid-dependent stress and anxiety elements. Steroids 68-75 translocator protein Rattus norvegicus 38-42 28432813-0 2017 Targeting on poly(ADP-ribose) polymerase activity with DNA-damaging hybrid lactam-steroid alkylators in wild-type and BRCA1-mutated ovarian cancer cells. Steroids 82-89 BRCA1 DNA repair associated Homo sapiens 118-123 2177625-5 1990 These data suggest that as well as AD, 5-ADIOL-S and DHEA-S may act as pro-hormones for more potent steroids (T and 5 alpha-dihydrotestosterone) in peripheral tissues, while 3 alpha-DIOL-S and 3 alpha-DIOL-G may both reflect peripheral androgen metabolism in patients with LOCAH. Steroids 100-108 sulfotransferase family 2A member 1 Homo sapiens 53-59 2243100-1 1990 Three beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta-HSD) catalyze the oxidative conversion of delta 5-3 beta-hydroxysteroids to the delta 4-3-keto configuration and is therefore essential for the biosynthesis of all classes of hormonal steroids, namely progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. Steroids 138-146 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-77 28043194-4 2017 Here, we sought to determine whether Fxr and Pxr signaling pathways are disrupted in response to high-circulating concentrations of steroid hormones late in pregnancy leading to altered transporter expression. Steroids 132-148 nuclear receptor subfamily 1, group I, member 2 Mus musculus 45-48 28938398-0 2017 Long-Term Recordings of Arcuate Nucleus Kisspeptin Neurons Reveal Patterned Activity That Is Modulated by Gonadal Steroids in Male Mice. Steroids 114-122 KiSS-1 metastasis-suppressor Mus musculus 40-50 2121466-6 1990 This response in the avian oviduct is unique since 1) it is the first demonstration of a steroid effect on c-jun expression in any animal system, 2) the changes in c-jun mRNA occur much more rapidly than most steroid responsive genes, and 3) it is the rare demonstration of an estrogen inhibition of the expression of a gene. Steroids 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 107-112 2121466-6 1990 This response in the avian oviduct is unique since 1) it is the first demonstration of a steroid effect on c-jun expression in any animal system, 2) the changes in c-jun mRNA occur much more rapidly than most steroid responsive genes, and 3) it is the rare demonstration of an estrogen inhibition of the expression of a gene. Steroids 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 164-169 2121466-7 1990 A role for the c-jun proto-oncogene as an early regulatory gene in the cascade model for steroid action is proposed. Steroids 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 15-20 28975994-0 2017 MiR-145 silencing promotes steroid-induced avascular necrosis of the femoral head repair via upregulating VEGF. Steroids 27-34 vascular endothelial growth factor A Oryctolagus cuniculus 106-110 2288648-2 1990 E2 and P at physiologic concentrations enhanced IL-1 beta and TNF production by monocytes from donors with lower control levels (without steroids added) of IL-1 beta and TNF. Steroids 137-145 cystatin 12, pseudogene Homo sapiens 0-8 2393857-8 1990 Progression to steroid autonomy in T-47-D cells was accompanied by an upregulation of transforming growth factor (TGF) alpha, TGF beta 1, and TGF beta 2 mRNA. Steroids 15-22 transforming growth factor beta 2 Homo sapiens 142-152 2164924-8 1990 Competition binding analyses of various steroids for MR and GR revealed markedly different patterns of steroid binding specificity for these receptors. Steroids 40-48 nuclear receptor subfamily 3 group C member 1 Canis lupus familiaris 60-62 19912752-1 1990 Effects of gonadal steroids on fos expression in the adult rat ventromedial hypothalamus (VMH) and uterus were examined using molecular hybridization and immunocytochemical techniques. Steroids 19-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-34 28823883-5 2017 Resveratrol competitively inhibited rat AKR1C9 and RDH2 against steroid substrates. Steroids 64-71 aldo-keto reductase family 1, member C14 Rattus norvegicus 40-46 2197880-0 1990 Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. Steroids 78-86 complement factor D Rattus norvegicus 8-15 28823883-6 2017 Docking showed that resveratrol bound to the steroid binding pocket of AKR1C9. Steroids 45-52 aldo-keto reductase family 1, member C14 Rattus norvegicus 71-77 2197880-0 1990 Reduced adipsin mRNA and circulating adipsin protein are modulated by adrenal steroids in obese Zucker rats. Steroids 78-86 complement factor D Rattus norvegicus 37-44 28270022-5 2017 Treatment was associated with reduction of serum CD44, a transmembrane glycoprotein associated with steroid and immunomodulatory drug resistance in MM. Steroids 100-107 CD44 molecule (Indian blood group) Homo sapiens 49-53 2197880-7 1990 The data thus suggest that adrenal steroids are involved in modulating adipsin expression in obese Zucker rats and that insulin may be an intermediary factor in such modulation. Steroids 35-43 complement factor D Rattus norvegicus 71-78 2133086-1 1990 A series of 17 alpha-acetylenic steroids was examined with regard to ability to inactivate human liver microsomal cytochrome P-450 (P-450) IIA4, an enzyme involved in the oxidation of a number of drugs, carcinogens, and steroids, including estrogens and progestogens. Steroids 32-40 cytochrome P450 family 2 subfamily A member 7 Homo sapiens 132-143 28926640-6 2017 In addition, we found extensive loss of MIST1+ secretory acinar cells in the Aire -/- lacrimal gland suggesting that acinar cells are a primary target of the disease, Finally, topical application of ophthalmic steroid effectively restored corneal innervation in Aire -/- mice thereby functionally linking nerve loss with local inflammation in the aqueous-deficient dry eye. Steroids 210-217 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Mus musculus 77-81 2341724-1 1990 alpha-1-Acid glycoprotein (AGP), which is produced in the mammalian liver and secreted into the blood-stream, is regulated by steroid hormones and by mediators of the acute phase response. Steroids 126-142 orosomucoid 1 Rattus norvegicus 0-25 2341724-1 1990 alpha-1-Acid glycoprotein (AGP), which is produced in the mammalian liver and secreted into the blood-stream, is regulated by steroid hormones and by mediators of the acute phase response. Steroids 126-142 orosomucoid 1 Rattus norvegicus 27-30 28926640-6 2017 In addition, we found extensive loss of MIST1+ secretory acinar cells in the Aire -/- lacrimal gland suggesting that acinar cells are a primary target of the disease, Finally, topical application of ophthalmic steroid effectively restored corneal innervation in Aire -/- mice thereby functionally linking nerve loss with local inflammation in the aqueous-deficient dry eye. Steroids 210-217 autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Mus musculus 262-266 1974319-4 1990 Glucocorticoid-mediated induction of glutamine synthetase was blocked by androgenic/anabolic steroids at high doses, suggesting that anabolic steroids might have an anticatabolic mode of action in enhancing skeletal muscle mass in athletes. Steroids 93-101 glutamate-ammonia ligase Rattus norvegicus 37-57 1974319-4 1990 Glucocorticoid-mediated induction of glutamine synthetase was blocked by androgenic/anabolic steroids at high doses, suggesting that anabolic steroids might have an anticatabolic mode of action in enhancing skeletal muscle mass in athletes. Steroids 142-150 glutamate-ammonia ligase Rattus norvegicus 37-57 28382513-2 2017 The androgen receptor (abbreviated AR) transcription factor is a major driver of prostate cancer pathology and activated by androgen steroid hormones. Steroids 133-149 androgen receptor Mus musculus 4-21 28593446-13 2017 CONCLUSIONS: To summarize, C3G with a severe crescentic phenotype is rare, affects children and young adults, and has a variable response to steroid and immunosuppressive treatment. Steroids 141-148 Rap guanine nucleotide exchange factor 1 Homo sapiens 27-30 2109683-11 1990 These data demonstrate that 1) c-fos and c-myc are expressed in ovarian granulosa cells; 2) the expression of the genes encoding c-fos, c-myc, and beta-actin is rapidly increased by gonadotropin; and 3) the increase in the corresponding products of the c-fos and the c-myc genes precedes an increase in DNA synthesis and steroid production. Steroids 321-328 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 2109683-11 1990 These data demonstrate that 1) c-fos and c-myc are expressed in ovarian granulosa cells; 2) the expression of the genes encoding c-fos, c-myc, and beta-actin is rapidly increased by gonadotropin; and 3) the increase in the corresponding products of the c-fos and the c-myc genes precedes an increase in DNA synthesis and steroid production. Steroids 321-328 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 129-134 2109683-11 1990 These data demonstrate that 1) c-fos and c-myc are expressed in ovarian granulosa cells; 2) the expression of the genes encoding c-fos, c-myc, and beta-actin is rapidly increased by gonadotropin; and 3) the increase in the corresponding products of the c-fos and the c-myc genes precedes an increase in DNA synthesis and steroid production. Steroids 321-328 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 129-134 28811502-8 2017 Treatment with estrogen and androgen receptor antagonists had opposite effects on Lep transcript abundance to steroid treatments, indicating that these transcriptional effects are mediated through the canonical steroid hormone signaling pathways. Steroids 110-117 androgen receptor Mus musculus 28-45 2193121-5 1990 We have also seen, however, that steroid medications used by patients to control their cerebral edema may depress the anti-tumor activity of rIL-2 by depressing the capacity of lymphocytes to develop normal LAK activity. Steroids 33-40 alpha kinase 1 Homo sapiens 207-210 28811502-8 2017 Treatment with estrogen and androgen receptor antagonists had opposite effects on Lep transcript abundance to steroid treatments, indicating that these transcriptional effects are mediated through the canonical steroid hormone signaling pathways. Steroids 211-226 androgen receptor Mus musculus 28-45 28479355-2 2017 UDP-glucuronosyltransferase (UGT) is an important class of phase II metabolizing enzymes, playing a pivotal role in detoxifying steroid hormone. Steroids 128-143 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 0-27 2318256-4 1990 Such a change in the levels of c-fos mRNA was not observed after administration of alpha-estradiol or other steroid hormones. Steroids 108-124 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 31-36 2106434-0 1990 Luteinizing hormone-releasing hormone neurons express c-fos antigen after steroid activation. Steroids 74-81 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 54-59 28479355-2 2017 UDP-glucuronosyltransferase (UGT) is an important class of phase II metabolizing enzymes, playing a pivotal role in detoxifying steroid hormone. Steroids 128-143 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 29-32 2106434-6 1990 These data demonstrate that gonadal steroids, administered in a paradigm that predictably produces timed stimulation of LH release, induce c-fos in LHRH neurons. Steroids 36-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-144 28624767-3 2017 Results showed that knockdown of NRF1 expression significantly inhibited the expression of STAR and CYP19A1, which are involved in sex steroid hormones synthesis, and led to lower estrogen levels. Steroids 135-151 steroidogenic acute regulatory protein, mitochondrial Capra hircus 91-95 28624767-3 2017 Results showed that knockdown of NRF1 expression significantly inhibited the expression of STAR and CYP19A1, which are involved in sex steroid hormones synthesis, and led to lower estrogen levels. Steroids 135-151 cytochrome P450 family 19 subfamily A member 1 Capra hircus 100-107 27862686-7 2017 The results confirm the role of IGF-I as a key anabolic hormone in male beef cattle and thus it may reflect growth differences due to altered sex steroids production. Steroids 146-154 IGFI Bos taurus 32-37 2160252-0 1990 Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture. Steroids 11-19 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 41-46 2160252-7 1990 The main action of the steroid on the GABAA receptor appears to be similar to that found for barbiturates, in that they prolonged GABA-activated bursts of channel openings. Steroids 23-30 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 38-43 2225773-0 1990 Comparison of delta-aminolaevulinic acid dehydratase activity in chick liver during sex steroid hormone dependent primary and secondary stimulation. Steroids 88-103 aminolevulinate dehydratase Gallus gallus 14-52 28412309-1 2017 We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may also be targeted by endocrine disrupting chemicals (EDCs). Steroids 77-93 receptor for activated C kinase 1 Homo sapiens 112-117 2144640-0 1990 Studies on the structural properties of lipocortin-1 and the regulation of its synthesis by steroids. Steroids 92-100 annexin A1 Homo sapiens 40-52 2144640-1 1990 Lipocortin-1 protein synthesis in resting monocytes is under the control of glucocorticoid steroids. Steroids 91-99 annexin A1 Homo sapiens 0-12 2144640-4 1990 In addition to the induction of intracellular lipocortin-1, steroids cause the appearance of labelled lipocortin-1 on the outer surface of the cells. Steroids 60-68 annexin A1 Homo sapiens 102-114 28412309-1 2017 We recently demonstrated the existence of a complex hormonal balance between steroid hormones in the control of RACK1 (Receptor for Activated C Kinase 1) expression and immune activation, suggesting that this scaffold protein may also be targeted by endocrine disrupting chemicals (EDCs). Steroids 77-93 receptor for activated C kinase 1 Homo sapiens 119-152 28575017-12 2017 In addition, we found that FOXC1 regulation of RAB3GAP1, RAB3GAP2 and SNAP25 affects secretion of Myocilin (MYOC), a protein associated with juvenile onset glaucoma and steroid-induced glaucoma. Steroids 169-176 RAB3 GTPase activating protein catalytic subunit 1 Homo sapiens 47-55 33971206-1 2021 Two pregnane-type of steroid derivatives characterized as 5alpha-pregna-3beta-methyl pent-3-enoate-12beta, 16beta diol-20-one (clathroid A) and 12beta,15beta- dihydroxypregna-4,6-diene-3,20-dione (clathroid B) were purified from the crude extract of the marine sponge, Clathria (Thalysias) vulpina (family Microcionidae) by extensive chromatographic fractionation. Steroids 21-28 ATPase H+ transporting accessory protein 1 Homo sapiens 107-113 28342744-3 2017 Hexacyclic steroids bearing a benzyl group at C-22, derived from 16-dehydropregnenolone and 16-dehydroprogesterone, show considerable cytotoxicity against EL4 (murine T-lymphoma) in contrast with the corresponding C-22-unsubstituted derivatives showing low cytotoxicity. Steroids 11-19 Sp7 transcription factor 7 Mus musculus 46-50 28342744-3 2017 Hexacyclic steroids bearing a benzyl group at C-22, derived from 16-dehydropregnenolone and 16-dehydroprogesterone, show considerable cytotoxicity against EL4 (murine T-lymphoma) in contrast with the corresponding C-22-unsubstituted derivatives showing low cytotoxicity. Steroids 11-19 epilepsy 4 Mus musculus 155-158 28399855-13 2017 CONCLUSION: Together we can conclude that this model does feature steroid sensitive, CD4+ T cell dependent, allergen induced LAR. Steroids 66-73 CD4 antigen Mus musculus 85-88 32795812-7 2020 More importantly, NET exposure induced the expressions of the genes (esr1, vtg1, hsd17b3, hsd11b2, ar) that are closely related to the steroid hormone pathways in the embryos/larvae stages, implying a precocious effects of NET in zebrafish. Steroids 135-142 hydroxysteroid (17-beta) dehydrogenase 3 Danio rerio 81-88 27554815-0 2017 Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways. Steroids 15-22 wingless-type MMTV integration site family, member 5A Mus musculus 44-49 27554815-12 2017 CONCLUSION: Our findings reveal age differences in LT and Wnt pathways during airway inflammation and identify a steroid-resistant cascade of Wnt5a, Tgm2, and LTs, which might represent a therapeutic target for airway inflammation and remodeling. Steroids 113-120 wingless-type MMTV integration site family, member 5A Mus musculus 142-147 33031748-8 2020 rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A in several tissues. Steroids 74-81 solute carrier family 51 subunit alpha Homo sapiens 23-29 28082305-5 2017 The steroid influences the spatial organization of GPCRs within the membrane bilayer, and consequently can tune chemokine receptor signaling. Steroids 4-11 C-X-C motif chemokine receptor 4 Homo sapiens 112-130 33031748-8 2020 rs5855544, upstream of SLC51A, was associated with higher levels of three steroid sulfates and co-localized with expression levels of SLC51A in several tissues. Steroids 74-81 solute carrier family 51 subunit alpha Homo sapiens 134-140 28840844-7 2017 The IL-17A levels were significantly correlated with those of IL-4, IL-25, IL-10, and IFN-gamma in patients with uncontrolled asthma, and the patients with the highest levels of all the above cytokines were refractory to high-dose of inhaled corticosteroid therapy and have a history of acute exacerbation within 1 year, requiring systemic steroid therapy. Steroids 249-256 interleukin 17A Homo sapiens 4-10 27749616-9 2017 CONCLUSIONS: Both US-guided and LM-guided steroid injections were effective in reducing the symptoms, improving the function and electrodiagnostic findings of CTS. Steroids 42-49 transthyretin Homo sapiens 159-162 26485545-2 2015 In the present study, effects of typical antipsychotic drug and AAPDs as well as treatment outcome of steroid antagonist mifepristone (MIF) on the PGRMC1/INSIG/SCAP/SREBP pathway were investigated in rat liver using real-time quantitative polymerase chain reaction (qPCR) and western blot analysis. Steroids 102-109 progesterone receptor membrane component 1 Rattus norvegicus 147-153 26485545-8 2015 Such metabolic defects can be modified by an add-on treatment of steroid antagonist MIF enhancing the PGRMC1 pathway. Steroids 65-72 progesterone receptor membrane component 1 Rattus norvegicus 102-108 34959084-1 2022 Porcine 17-hydroxysteroid dehydrogenase type 14 (HSD17B14) and FSH reporter (FSHR) genes play important roles in the metabolism of steroid hormones and the apoptosis of ovarian granulosa cells (GCs). Steroids 131-138 follicle stimulating hormone receptor Homo sapiens 77-81 34688215-7 2022 The transcript levels of steroid hormone receptors (ESR1, ESR2, PGR) and growth factors (IGF1, IGF2, VEGFA) were investigated and their expression localized by immunohistochemical staining. Steroids 25-32 estrogen receptor Ovis aries 52-56 34619591-0 2022 Ecological and human health risks of manure-borne steroid estrogens: A 20-year global synthesis study. Steroids 50-57 immunoglobulin kappa variable 1-27 Homo sapiens 69-73 34910686-0 2021 METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6. Steroids 61-68 methyltransferase 14, N6-adenosine-methyltransferase subunit Homo sapiens 0-7 34910686-0 2021 METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6. Steroids 61-68 glycoprotein M6A Homo sapiens 132-135 34910686-0 2021 METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6. Steroids 61-68 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 145-150 34852451-11 2021 In several pathway analyses, the Wnt signaling pathway was downregulated and the steroid biosynthesis pathway was upregulated in PRKACA mutants. Steroids 81-88 protein kinase cAMP-activated catalytic subunit alpha Homo sapiens 129-135 34852451-12 2021 Protein-protein interaction analysis also showed that PRKACA downregulates Wnt signaling and upregulates steroid biosynthesis. Steroids 105-112 protein kinase cAMP-activated catalytic subunit alpha Homo sapiens 54-60 34546486-8 2021 Apart from structure similarities, our data revealed the strongest interaction of zebrafish Oatp2b1 with bile acids, steroid sulfates, thyroid hormones, and bilirubin, as well as xenobiotics bromosulfophthalein and sulfasalazine, which indicates its functional orthology with human OATP2B1. Steroids 117-124 solute carrier organic anion transporter family, member 2B1 Danio rerio 92-99 34581457-10 2021 In addition, MSI2 overexpression was associated with characteristics of unfavorable prognosis, such as cortisol excess (p = .002), recurrence (p =.003), and death (p =.015); positively correlated with genes related to steroid biosynthesis (p < .05); and negatively correlated with immune-related pathways (p < .05). Steroids 218-225 musashi RNA binding protein 2 Homo sapiens 13-17 34762910-0 2021 An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function. Steroids 78-85 SRY (sex determining region Y)-box 2 Mus musculus 65-69 34762910-0 2021 An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function. Steroids 78-85 SRY (sex determining region Y)-box 2 Mus musculus 120-124 34762910-3 2021 Here we used an in vitro protein-protein interaction assay to discover transcriptional regulators for embryonic stem cell core transcription factors (Oct4, Sox2, Klf4 and c-Myc) and identified members of the steroid receptor coactivators (SRCs) as Sox2-specific interacting proteins. Steroids 208-215 SRY (sex determining region Y)-box 2 Mus musculus 248-252 34881290-12 2021 Remarkably, the fruit fly Drosophila melanogaster, expresses a GSTE14 with notable steroid isomerase activity, even though Ser14 has evolved as the active-site residue corresponding to Tyr9 in the mammalian alpha class. Steroids 83-90 Glutathione S transferase E14 Drosophila melanogaster 63-69 34781165-0 2021 The sex steroid precursor dehydroepiandrosterone prevents nonalcoholic steatohepatitis by activating the AMPK pathway mediated by GPR30. Steroids 8-15 G protein-coupled estrogen receptor 1 Homo sapiens 130-135 34170319-2 2021 Recently, biallelic variants in the nuclear pore complex (NPC) component nucleoporin 85 gene (NUP85) were reported to cause steroid-resistant nephrotic syndrome (SRNS). Steroids 124-131 nucleoporin 85 Homo sapiens 73-87 34170319-2 2021 Recently, biallelic variants in the nuclear pore complex (NPC) component nucleoporin 85 gene (NUP85) were reported to cause steroid-resistant nephrotic syndrome (SRNS). Steroids 124-131 nucleoporin 85 Homo sapiens 94-99 34157324-3 2021 PURPOSE: The study was designed to explore the effect of suPAR and uPAR in SRNS patients and evaluate the potential effect of SAA in improving podocyte steroid resistance and explore its mechanism. Steroids 152-159 serum amyloid A1 cluster Homo sapiens 126-129 34631494-0 2021 COVID-19, Diabetes and Steroids: The Demonic Trident for Mucormycosis. Steroids 23-31 forkhead box M1 Homo sapiens 45-52 34339750-1 2021 BACKGROUND: Many neuroactive steroids induce sedation/hypnosis by potentiating gamma-aminobutyric acid (GABAA) currents. Steroids 29-37 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 104-109 34402503-3 2021 The lncRNA, SRA, known as Steroid receptor activator, acts as an important modulator of gynecological cancer, and its expression may affect biological functions including proliferation, apoptosis, steroid formation and muscle developments. Steroids 26-33 steroid receptor RNA activator 1 Homo sapiens 12-15 34402503-3 2021 The lncRNA, SRA, known as Steroid receptor activator, acts as an important modulator of gynecological cancer, and its expression may affect biological functions including proliferation, apoptosis, steroid formation and muscle developments. Steroids 197-204 steroid receptor RNA activator 1 Homo sapiens 12-15 34521750-5 2021 Here, we show that in AD, IL-4 and IL-13 stimulate the expression of 3beta-hydroxysteroid dehydrogenase 1 (HSD3B1), a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin. Steroids 150-157 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 69-105 34521750-5 2021 Here, we show that in AD, IL-4 and IL-13 stimulate the expression of 3beta-hydroxysteroid dehydrogenase 1 (HSD3B1), a key rate-limiting enzyme in sex steroid hormone synthesis, predominantly expressed by sebaceous glands in human skin. Steroids 150-157 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 107-113 34502490-7 2021 We conclude that Th17/Th1 cells are generated locally, are resistant to the immunosuppressive effects of steroids, and contribute to early development of EAU. Steroids 105-113 negative elongation factor complex member C/D Homo sapiens 22-25 34391879-0 2022 Human HAND1 Inhibits the Conversion of Cholesterol to Steroids in Trophoblasts. Steroids 54-62 heart and neural crest derivatives expressed 1 Homo sapiens 6-11 34281980-3 2021 Two different populations of Kiss1 neurons, one in the arcuate nucleus (Kiss1ARH) and another in the anteroventral periventricular and periventricular nucleus (Kiss1AVPV/PeN) of the hypothalamus are differentially regulated by ovarian steroids, and are believed to form direct contacts with GnRH neurons as well as other neurons. Steroids 235-243 KiSS-1 metastasis-suppressor Mus musculus 29-34 34281980-3 2021 Two different populations of Kiss1 neurons, one in the arcuate nucleus (Kiss1ARH) and another in the anteroventral periventricular and periventricular nucleus (Kiss1AVPV/PeN) of the hypothalamus are differentially regulated by ovarian steroids, and are believed to form direct contacts with GnRH neurons as well as other neurons. Steroids 235-243 KiSS-1 metastasis-suppressor Mus musculus 72-80 34281980-3 2021 Two different populations of Kiss1 neurons, one in the arcuate nucleus (Kiss1ARH) and another in the anteroventral periventricular and periventricular nucleus (Kiss1AVPV/PeN) of the hypothalamus are differentially regulated by ovarian steroids, and are believed to form direct contacts with GnRH neurons as well as other neurons. Steroids 235-243 KiSS-1 metastasis-suppressor Mus musculus 160-169 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 17-24 KiSS-1 metastasis-suppressor Mus musculus 35-40 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 17-24 KiSS-1 metastasis-suppressor Mus musculus 206-216 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 17-24 KiSS-1 metastasis-suppressor Mus musculus 218-223 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 17-24 KiSS-1 metastasis-suppressor Mus musculus 329-339 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 254-261 KiSS-1 metastasis-suppressor Mus musculus 35-40 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 254-261 KiSS-1 metastasis-suppressor Mus musculus 206-216 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 254-261 KiSS-1 metastasis-suppressor Mus musculus 218-223 34281980-10 2021 Therefore, these steroid-sensitive Kiss1 neuronal groups can differentially control the excitability of target neurons to coordinate autonomic functions with reproduction.Significance StatementHypothalamic kisspeptin (Kiss1) neurons are the most gonadal steroid-sensitive neurons in the brain, and its principle neurotransmitter kisspeptin is essential for sexual development and reproduction through direct excitation of GnRH neurons. Steroids 254-261 KiSS-1 metastasis-suppressor Mus musculus 329-339 34296353-7 2022 Serum FGF-23 level gradually decreased as urinary protein levels decreased after treatment with steroids; however, there was no change in the high-intensity area on MRI. Steroids 96-104 fibroblast growth factor 23 Homo sapiens 6-12 34254805-2 2021 In these areas, binding sites for TSPO ligands were recognized in steroid-producing tissues. Steroids 66-73 translocator protein Homo sapiens 34-38 34306216-7 2021 We identified four novel DEGs (MROH5, LOC113840576, SDR42E1, and LOC113841457) with key roles in the regulation of steroid hormone biosynthesis. Steroids 115-122 short-chain dehydrogenase/reductase family 42E member 1 Anas platyrhynchos 52-59 34299256-8 2021 IVIg/steroid treatment significantly decreased IFN-gamma and IL-10 expression. Steroids 5-12 interleukin 10 Homo sapiens 61-66 34298978-4 2021 Let-7d expression is regulated by cytokines and steroids, involving transcriptional regulation by OCT4, MYC and p53, as well as posttranscriptional regulation via LIN28 and ADAR. Steroids 48-56 POU domain, class 5, transcription factor 1 Mus musculus 98-102 34160439-1 2021 INTRODUCTION: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an increasingly recognized type of steroid-responsive autoimmune disease of the nervous system. Steroids 117-124 glial fibrillary acidic protein Homo sapiens 25-56 34160439-1 2021 INTRODUCTION: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an increasingly recognized type of steroid-responsive autoimmune disease of the nervous system. Steroids 117-124 glial fibrillary acidic protein Homo sapiens 58-62 34206570-0 2021 RP-18 TLC Chromatographic and Computational Study of Skin Permeability of Steroids. Steroids 74-82 pre-mRNA processing factor 3 Homo sapiens 0-5 34090475-0 2021 Serum tenascin-C predicts resistance to steroid combination therapy in high-risk Kawasaki disease: a multicenter prospective cohort study. Steroids 40-47 tenascin C Homo sapiens 6-16 34090475-10 2021 CONCLUSIONS: Serum tenascin-C could be a biomarker for predicting the risk of high-risk patients being non-responsive to steroid combination therapy. Steroids 121-128 tenascin C Homo sapiens 19-29 28135243-4 2017 Here we identify a steroid-responsive subset of neurotensin (Nts)-expressing mPOA neurons that interface with the ventral tegmental area (VTA) to form a socially engaged reward circuit. Steroids 19-26 neurotensin Mus musculus 48-59 28135243-4 2017 Here we identify a steroid-responsive subset of neurotensin (Nts)-expressing mPOA neurons that interface with the ventral tegmental area (VTA) to form a socially engaged reward circuit. Steroids 19-26 neurotensin Mus musculus 61-64 28384968-7 2017 We hereby, report a rare case of a 65-year-old female with intractable fasting hypoglycaemia due to overproduction of "big" insulin-like growth factor II diagnosed to have pelvic GIST and managed by Steroids and Imatinib. Steroids 199-207 insulin Canis lupus familiaris 124-131 34079822-4 2021 In addition, sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones, but not bile acids. Steroids 94-101 solute carrier family 10 member 6 Homo sapiens 13-55 34079822-4 2021 In addition, sodium-dependent organic anion transporter SOAT specifically transports sulfated steroid hormones, but not bile acids. Steroids 94-101 solute carrier family 10 member 6 Homo sapiens 56-60 34194927-5 2021 Molecular analysis reveals that vascular endothelial growth factor C (VEGF-C) is highly induced in MSCs by steroids and TNFalpha and VEGF-C in turn promotes CD8+ T cell response. Steroids 107-115 CD8a molecule Homo sapiens 157-160 34194927-9 2021 Thus, the data demonstrate that steroids can reverse the immunosuppressive effect of MSCs via promoting VEGF-C-augmented CD8+ T cell response and provide novel information for designing efficacious MSC-based therapies. Steroids 32-40 CD8a molecule Homo sapiens 121-124 27837331-8 2017 CONCLUSIONS: These sex differences, while unexpected, may be due to interactions with gonadal steroids and may be relevant to sexually dimorphic disorders of social cognition, such as male-biased autism spectrum disorder, for which oxytocin has been proposed as a potential treatment. Steroids 94-102 oxytocin/neurophysin I prepropeptide Homo sapiens 232-240 35475923-2 2022 IL-17 is considered to induce neutrophilic inflammation in the lung, which is often observed in severe, steroid-resistant asthma-phenotypes. Steroids 104-111 interleukin 17A Homo sapiens 0-5 35398259-10 2022 These results suggest that AKR1C1 and AKR1C4 function as 3alpha/3beta/17beta/20alpha-HSD and 3alpha-HSD, respectively, in metabolism of steroid hormones and a sex pheromone androstenone, both of which also play roles in metabolism of nonsteroidal carbonyl compounds. Steroids 136-143 aldo-keto reductase family 1 member C4 Homo sapiens 38-44 28066427-0 2016 Steroid Resistant CD8+CD28null NKT-Like Pro-inflammatory Cytotoxic Cells in Chronic Obstructive Pulmonary Disease. Steroids 0-7 CD8a molecule Homo sapiens 18-21 35508278-4 2022 In the present study, we provide evidence for the insulin-sensitizing role of smoothelin-like protein 1 (SMTNL1) that is a ligand-dependent co-regulator of steroid receptors, predominantly the progesterone receptor. Steroids 156-163 progesterone receptor Mus musculus 193-214 28066427-9 2016 This mini review will focus on cytotoxic pro-inflammatory CD8+CD28null NKT-like cells involved in COPD and novel approaches to reverse steroid resistance in these cells. Steroids 135-142 CD8a molecule Homo sapiens 58-61 27623070-8 2016 RESULTS: Of the Delta5-steroid sulfates quantified, DHEA-S was most abundant. Steroids 23-30 sulfotransferase family 2A member 1 Homo sapiens 52-58 35609516-10 2022 RESULTS: Plasma SIRT-1 increased significantly during steroid administration. Steroids 54-61 sirtuin 1 Homo sapiens 16-22 35609516-13 2022 In a multiple regression model changes of plasma sclerostin induced by steroid therapy explained the largest part of variance of respective changes of plasma SIRT-1. Steroids 71-78 sirtuin 1 Homo sapiens 158-164 35609516-14 2022 CONCLUSIONS: Plasma SIRT-1 increase during high-dose corticosteroid therapy is negatively related to the change of plasma sclerostin that may suggest a protective role of SIRT-1 against the negative effects of steroid therapy on bone. Steroids 210-217 sirtuin 1 Homo sapiens 20-26 27623070-10 2016 Steroid ratios (17OHPreg-S/DHEA-S) suggested increases in 17,20-lyase activity during childhood. Steroids 0-7 sulfotransferase family 2A member 1 Homo sapiens 27-33 27888992-3 2016 IL-17 is associated with neutrophilic inflammation, steroid resistance and severe asthma, but its importance in the association between asthma and obesity is unknown. Steroids 52-59 interleukin 17A Homo sapiens 0-5 35553329-2 2022 The present study was aimed to evaluate the expression status of selected miRNAs (miR-1, miR-215-5p, miR-335-5p and let-7a-5p) in urine samples from children with NS (steroid sensitive (SSNS)) and (steroid resistant (SRNS)) along with healthy control group. Steroids 167-174 microRNA 215 Homo sapiens 89-96 27452639-8 2016 GM analysis revealed that n-3 PUFA supplementation increased renal steroid hormone and proteolytic metabolite levels in PMW. Steroids 67-82 pumilio RNA binding family member 3 Homo sapiens 30-34 35553638-1 2022 We previously showed increased steroid-resistant CD28null CD8+ senescent lymphocyte subsets in the peripheral blood from patients with chronic obstructive pulmonary disease (COPD). Steroids 31-38 CD8a molecule Homo sapiens 58-61 35574290-2 2022 Mutations in the protein coding paired box gene 2 (PAX2) and in the non-muscle class I myosin, myosin 1E, (MYO1E) have been implicated in the development of steroid-resistant nephrotic syndrome. Steroids 157-164 paired box 2 Homo sapiens 32-49 35574290-2 2022 Mutations in the protein coding paired box gene 2 (PAX2) and in the non-muscle class I myosin, myosin 1E, (MYO1E) have been implicated in the development of steroid-resistant nephrotic syndrome. Steroids 157-164 paired box 2 Homo sapiens 51-55 27396977-0 2016 P-glycoprotein overexpression in bone marrow-derived multipotent stromal cells decreases the risk of steroid-induced osteonecrosis in the femoral head. Steroids 101-108 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-14 27396977-1 2016 P-glycoprotein (P-gp) plays a role in steroid-induced osteonecrosis of the femoral head (ONFH), but the underlying mechanism remains unknown. Steroids 38-45 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-14 27396977-1 2016 P-glycoprotein (P-gp) plays a role in steroid-induced osteonecrosis of the femoral head (ONFH), but the underlying mechanism remains unknown. Steroids 38-45 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 16-20 27396977-12 2016 Overexpression of P-gp inhibited BMSC adipogenesis and promoted osteogenesis, which reduced the incidence of steroid-induced ONFH. Steroids 109-116 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 18-22 35614914-10 2022 High-dose steroid therapy treatment was administered based on positive anti-TPO findings, which failed to elicit any improvement and the patient continued to decline. Steroids 10-17 thyroid peroxidase Homo sapiens 76-79 27378744-0 2016 Differential expression of miR-672-5p and miR-146a-5p in osteoblasts in rats after steroid intervention. Steroids 83-90 microRNA 672 Rattus norvegicus 27-34 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. Steroids 35-42 interleukin 10 Homo sapiens 75-80 27378744-12 2016 RT-PCR results showed that the 2(- ) CT value of miR-672-5p in the steroid group was 3.743-fold of that in the control group, and the 2(- ) CT value of miR-146a-5p in the steroid group was 0.322-fold of that in the control group. Steroids 68-75 microRNA 672 Rattus norvegicus 50-57 27378744-12 2016 RT-PCR results showed that the 2(- ) CT value of miR-672-5p in the steroid group was 3.743-fold of that in the control group, and the 2(- ) CT value of miR-146a-5p in the steroid group was 0.322-fold of that in the control group. Steroids 173-180 microRNA 672 Rattus norvegicus 50-57 27378744-14 2016 CONCLUSION: Expression profiles of miR-672-5p and miR-146a-5p had the most significant changes in the osteoblasts of rats with steroid intervention, which may provide a new viewpoint to pathogenesis of osteonecrosis of the femoral head. Steroids 127-134 microRNA 672 Rattus norvegicus 35-42 35131439-8 2022 Factors associated with both MDC1 and MDC2, respectively, were medium dose steroid use (adjusted odds ratio (aOR) 2.11, 2.01), high dose steroid use (aOR 4.70, 2.50), intermediate medical care service (aOR 1.65, 1.55), infection (aOR 1.21, 1.34) and hepatic disease (aOR 1.93, 1.92). Steroids 75-82 mediator of DNA damage checkpoint 1 Homo sapiens 29-33 27529315-1 2016 BACKGROUND: The neuroactive steroid allopregnanolone (ALLO) is an endogenous allosteric modulator of gamma-aminobutyric acid type A (GABAA) receptors. Steroids 28-35 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 133-138 35131439-8 2022 Factors associated with both MDC1 and MDC2, respectively, were medium dose steroid use (adjusted odds ratio (aOR) 2.11, 2.01), high dose steroid use (aOR 4.70, 2.50), intermediate medical care service (aOR 1.65, 1.55), infection (aOR 1.21, 1.34) and hepatic disease (aOR 1.93, 1.92). Steroids 137-144 mediator of DNA damage checkpoint 1 Homo sapiens 29-33 35139664-8 2022 Familial hyperaldosteronism, typically with early onset, is caused by germline mutations in steroid 11-beta hydroxylase/aldosterone synthase (CYP11B1/2), CLCN2, KCNJ5, CACNA1H, and CACNA1D. Steroids 92-99 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 142-151 35417913-0 2022 Associations of the Methylation Levels of NFAT5, PVT1, RPS6KA1, and MIB1 with Steroid-Resistant Asthma. Steroids 78-85 MIB E3 ubiquitin protein ligase 1 Homo sapiens 68-72 35417913-1 2022 BACKGROUND: This study detected the methylation levels of nuclear factor-5 (NFAT5), PVT1, ribosomal protein S6 kinase A-1 (RPS6KA1), and MIB1 in patients with steroid-resistant asthma (SRA) and explored their associations with SRA. Steroids 159-166 MIB E3 ubiquitin protein ligase 1 Homo sapiens 137-141 35417913-1 2022 BACKGROUND: This study detected the methylation levels of nuclear factor-5 (NFAT5), PVT1, ribosomal protein S6 kinase A-1 (RPS6KA1), and MIB1 in patients with steroid-resistant asthma (SRA) and explored their associations with SRA. Steroids 159-166 steroid receptor RNA activator 1 Homo sapiens 185-188 27411106-0 2016 Antenatal steroid exposure in the late preterm period is associated with reduced cord blood neurotrophin-3. Steroids 10-17 neurotrophin 3 Homo sapiens 92-106 35417913-1 2022 BACKGROUND: This study detected the methylation levels of nuclear factor-5 (NFAT5), PVT1, ribosomal protein S6 kinase A-1 (RPS6KA1), and MIB1 in patients with steroid-resistant asthma (SRA) and explored their associations with SRA. Steroids 159-166 steroid receptor RNA activator 1 Homo sapiens 227-230 35405676-8 2022 CONCLUSIONS: Our study found that ITP patients with anti-GP IIb/IIIa may have a higher response to steroids treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroids treatment. Steroids 99-107 integrin subunit alpha 2b Homo sapiens 57-63 27411106-3 2016 Antenatal steroid exposure can alter neurotrophin concentrations, yet studies to date have not examined whether this occurs in the late preterm infant (33-36weeks gestation), despite increasing recognition of subtle neurodevelopmental deficits in this population. Steroids 10-17 brain derived neurotrophic factor Homo sapiens 37-49 27411106-9 2016 In the late preterm period, cord blood NT-3 was reduced when antenatal steroids were administered >24h prior to delivery (p<0.01). Steroids 71-79 neurotrophin 3 Homo sapiens 39-43 27411106-10 2016 CONCLUSION: This study identified an association between reduced cord blood NT-3 and antenatal steroid exposure in the late preterm period. Steroids 95-102 neurotrophin 3 Homo sapiens 76-80 27411106-11 2016 The reduced NT-3 may be a consequence of steroids inducing neuronal apoptosis, thereby reducing endogenous neuronal NT3 production, or be an action of steroids on other maternal or fetal NT-3 producing cells, which may then affect neuronal growth, differentiation and survival. Steroids 41-49 neurotrophin 3 Homo sapiens 12-16 27411106-11 2016 The reduced NT-3 may be a consequence of steroids inducing neuronal apoptosis, thereby reducing endogenous neuronal NT3 production, or be an action of steroids on other maternal or fetal NT-3 producing cells, which may then affect neuronal growth, differentiation and survival. Steroids 151-159 neurotrophin 3 Homo sapiens 187-191 27540309-2 2016 The aim of this study was to determine the frequency and the association of VDR gene polymorphisms with idiopathic nephrotic syndrome (INS) and steroid responsiveness in Kuwaiti children. Steroids 144-151 vitamin D receptor Homo sapiens 76-79 27459539-0 2016 MicroRNA-145 Mediates Steroid-Induced Necrosis of the Femoral Head by Targeting the OPG/RANK/RANKL Signaling Pathway. Steroids 22-29 basic transcription factor 3 pseudogene 11 Homo sapiens 84-87 27459539-0 2016 MicroRNA-145 Mediates Steroid-Induced Necrosis of the Femoral Head by Targeting the OPG/RANK/RANKL Signaling Pathway. Steroids 22-29 TNF superfamily member 11 Homo sapiens 93-98 27757302-9 2016 The analysis of repeat samples revealed that resolution of the colitis was associated with a decrease in CD8+ and FoxP3+ cells both in patients treated with steroids and infliximab. Steroids 157-165 CD8a molecule Homo sapiens 105-108 27139182-2 2016 Human 3beta-hydroxysteroid dehydrogenase type 1 (3beta-HSD type 1) is a critical enzyme in the formation of all classes of active steroid hormones, and is also involved in the inactivation of potent androgen dihydrotestosterone (DHT). Steroids 130-146 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 6-47 26566264-5 2016 In this study, we assessed the effect of sex steroids on BDNF expression and secretion in human airway smooth muscle (ASM). Steroids 45-53 brain derived neurotrophic factor Homo sapiens 57-61 26566264-12 2016 The relevance of sex steroid-BDNF interactions may lie in their overall contribution to airway diseases such as asthma. Steroids 21-28 brain derived neurotrophic factor Homo sapiens 29-33 27462133-2 2016 The present study was attempted to localize EFA6 type D (EFA6D) in mouse adrenocortical cells in situ whose steroid hormone secretion is generally considered not to depend on the vesicle-involved regulatory mechanism. Steroids 108-123 pleckstrin and Sec7 domain containing 3 Mus musculus 44-55 27335359-1 2016 CD8+ encephalitis (CD8+E) is an emerging and incompletely understood HIV-associated neurological syndrome, typically presenting as a steroid-responsive subacute encephalopathy with prominent white matter changes in patients with apparently well-controlled HIV infection. Steroids 133-140 CD8a molecule Homo sapiens 0-3 27335359-1 2016 CD8+ encephalitis (CD8+E) is an emerging and incompletely understood HIV-associated neurological syndrome, typically presenting as a steroid-responsive subacute encephalopathy with prominent white matter changes in patients with apparently well-controlled HIV infection. Steroids 133-140 CD8a molecule Homo sapiens 19-22 27335359-3 2016 We report a case of CD8+E where the initial positive response to steroid treatment was followed by several relapses on withdrawal. Steroids 65-72 CD8a molecule Homo sapiens 20-23 27149376-8 2016 Real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a significant increase in mRNA levels for placental steroid metabolism enzymes, including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 (SULT1E1), steroid 5alpha-reductase 1 (SRD5A1) and steroid 5alpha-reductase 2 (SRD5A2). Steroids 152-159 steroid 5 alpha-reductase 2 Rattus norvegicus 313-339 27149376-8 2016 Real-time quantitative reverse transcriptase-polymerase chain reaction (Q-RT-PCR) analysis revealed a significant increase in mRNA levels for placental steroid metabolism enzymes, including UDP-glucuronosyltransferase 1A1 (UGT1A1), estrogen sulfotransferase 1E1 (SULT1E1), steroid 5alpha-reductase 1 (SRD5A1) and steroid 5alpha-reductase 2 (SRD5A2). Steroids 152-159 steroid 5 alpha-reductase 2 Rattus norvegicus 341-347 26781490-8 2016 RT-qPCR was performed to determine the regulatory mechanism of Herp knockdown in the cell cycle, and in steroid synthesis, RT-qPCR analysis revealed that Herp knockdown upregulated the mRNA expression of steroidogenic enzymes (Cyp19a1) and downregulated metabolic enzymes (Cyp1b1) and cell cycle factors (cyclin A1, cyclin B1 and cyclin D2). Steroids 104-111 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 Mus musculus 154-158 26657237-2 2016 In this study, the authors aimed at comparing the clinical and electrophysiologic recovery of CTS after local steroid injection and operation. Steroids 110-117 transthyretin Homo sapiens 94-97 26657237-12 2016 And surgery is more effective technique than steroid injection for the treatment of the moderate CTS in the long term. Steroids 45-52 transthyretin Homo sapiens 97-100 26781511-8 2016 Clustering of the concentration-dependent chemical-mediated steroid hormone effects grouped chemical samples into 5 distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition. Steroids 60-75 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 210-215 26405064-0 2016 Effects of Fluticasone Furoate on Clinical and Immunological Outcomes (IL-17) for Patients With Nasal Polyposis Naive to Steroid Treatment. Steroids 121-128 interleukin 17A Homo sapiens 71-76 26405064-8 2016 The IL-17A/F expression was higher in nonallergics with high neutrophil counts and was inclined by steroids. Steroids 99-107 interleukin 17A Homo sapiens 4-10 26562263-2 2016 Arcuate kisspeptin (kisspeptin, neurokinin B, and dynorphin [KNDy]) neurons may convey steroid feedback to GnRH neurons. Steroids 87-94 KiSS-1 metastasis-suppressor Mus musculus 8-18 26562263-2 2016 Arcuate kisspeptin (kisspeptin, neurokinin B, and dynorphin [KNDy]) neurons may convey steroid feedback to GnRH neurons. Steroids 87-94 KiSS-1 metastasis-suppressor Mus musculus 20-30 26562263-6 2016 We hypothesized the same gonadal steroids affecting GnRH firing pattern would regulate KNDy neuron response to NK3R and KOR agonists. Steroids 33-41 opioid receptor, kappa 1 Mus musculus 120-123 26562263-11 2016 These observations suggest the steroid modulation of responses to activation of NK3R and KOR as mechanisms for negative feedback in KNDy neurons and support the contribution of these neurons to steroid-sensitive elements of a GnRH pulse generator. Steroids 31-38 opioid receptor, kappa 1 Mus musculus 89-92 26528893-3 2016 Neurons expressing the inhibitory and stimulatory neuropeptides, RFamide-related peptide (RFRP) and kisspeptin, respectively, project to neural loci regulating aggression in addition to neuroendocrine cells controlling sex steroid production. Steroids 223-230 KiSS-1 metastasis-suppressor Mus musculus 100-110 26581634-8 2016 These results strongly suggested that MBP raised steroid hormone synthesis via upregulated vimentin by miRNA-200c. Steroids 49-64 vimentin Mus musculus 91-99 26792978-0 2016 Urinary Vitamin D-Binding Protein as a Biomarker of Steroid-Resistant Nephrotic Syndrome. Steroids 52-59 GC vitamin D binding protein Homo sapiens 8-33 26472732-8 2016 Moreover, synthetic steroids (methyltestosterone and nandrolone) used as anabolics as well as all-trans-retinol were for the first time identified as substrates of DHRS8. Steroids 20-28 hydroxysteroid 17-beta dehydrogenase 11 Homo sapiens 164-169 26138474-2 2016 The aim of the present study was to determine contributions of genetic factors and gonadal steroid hormones to the sexual differentiation of kisspeptin-immunoreactive (kisspeptin-ir) cell populations in the AVPV and Arc during postnatal development using agonadal steroidogenic factor 1 (SF-1) knockout (KO) mice. Steroids 91-107 KiSS-1 metastasis-suppressor Mus musculus 168-178 26646518-4 2016 After subchronic treatment (i.e., for 20 days) the following effects were detected: (i) depending on the compartment considered, alteration in the levels of neuroactive steroids, not only in 5alpha-reduced metabolites but also in its precursors and in neuroactive steroids from other steroidogenic pathways and (ii) an upregulation of the androgen receptor in the cerebral cortex and beta3 subunit of the GABA-A receptor in the cerebellum. Steroids 169-177 androgen receptor Rattus norvegicus 339-356 26666359-1 2016 Dehydroepiandrosterone sulfate (DHEAS) and estrone sulfate (E1S) are two of the most abundant steroids in the human circulation. Steroids 94-102 sulfotransferase family 2A member 1 Homo sapiens 32-37 26915843-9 2016 Recipients of steroid-free ISx were less commonly treated for post-transplantation diabetes. Steroids 14-21 intestine specific homeobox Homo sapiens 27-30 26362599-8 2015 This suggests that C/EBPalpha might be involved in the regulation of LIPE expression and thus cholesterol supply for steroid hormone synthesis. Steroids 117-132 lipase E, hormone sensitive type Homo sapiens 69-73 26303523-12 2015 The decrease in miR-195 led to an increase in Smad7 expression and corresponding up-regulation of p65 and the AP-1 (activator protein 1) pathway, which might explain the mechanism of steroid resistance in UC patients. Steroids 183-190 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 110-135 26348127-9 2015 It also suggests that the abundance, distribution and activity of TRPC6 can be regulated by cardiotonic steroids like ouabain and the naturally occurring peptide Abeta(1-40) which underlines the pathophysiological significance of these processes. Steroids 104-112 transient receptor potential cation channel, subfamily C, member 6 Mus musculus 66-71 26316550-3 2015 Here we prove with evidence that steroid hormones estradiol (E), progesterone (P), and human chorionic gonadotropin (hCG), as well as decidual stromal cells (DSCs) could regulate the expression of CCL24 and CCR3 of trophoblasts. Steroids 33-49 C-C motif chemokine receptor 3 Homo sapiens 207-211 26513582-10 2015 We observed trends towards a protective effect of the dominant G allele at SPP1 rs28357094 and recessive T allele at LTBP4 rs10880, which was statistically significant in steroid-treated patients for LTBP4 rs10880 (< 50% T/T patients developing DCM during follow-up [n = 13]; median DCM onset 17.6 years for C/C-C/T, log-rank p = 0.027). Steroids 171-178 latent transforming growth factor beta binding protein 4 Homo sapiens 117-122 26513582-10 2015 We observed trends towards a protective effect of the dominant G allele at SPP1 rs28357094 and recessive T allele at LTBP4 rs10880, which was statistically significant in steroid-treated patients for LTBP4 rs10880 (< 50% T/T patients developing DCM during follow-up [n = 13]; median DCM onset 17.6 years for C/C-C/T, log-rank p = 0.027). Steroids 171-178 latent transforming growth factor beta binding protein 4 Homo sapiens 200-205 26303142-5 2015 Whereas transient expression of RARalpha and RXRalpha enhanced 9-cis RA induced StAR gene transcription, silencing of RXRalpha with siRNA, decreased StAR and steroid levels. Steroids 158-165 retinoid X receptor alpha Homo sapiens 118-126 26465008-7 2015 In summary, these novel findings indicate that estrogens differentially regulate PR-A and PR-B expression in the female hypothalamus, and provide a mechanism by which steroid action in brain can selectively modulate behavior and physiology. Steroids 167-174 progesterone receptor Mus musculus 90-94 26258540-8 2015 Specifically, miR-28, miR-26, and let-7b previously shown to inhibit sex steroid production in human granulosa cells, were up-regulated. Steroids 73-80 microRNA let-7b Homo sapiens 34-40 25981801-6 2015 With a low expression of DLD, heavy metals dramatically reduced the levels of steroid hormone by inhibiting the activation of cAMP/PKA, PKC signaling pathway and the steroidogenic enzymes StAR, CYP11A1 and 3beta-HSD. Steroids 78-93 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 194-215 26551690-1 2015 The translocator protein (18 kDa) (TSPO) resides on the outer mitochondrial membrane where it is believed to participate in cholesterol transport and steroid hormone synthesis. Steroids 150-165 translocator protein Homo sapiens 4-33 26551690-1 2015 The translocator protein (18 kDa) (TSPO) resides on the outer mitochondrial membrane where it is believed to participate in cholesterol transport and steroid hormone synthesis. Steroids 150-165 translocator protein Homo sapiens 35-39 26236183-5 2015 We find that V1rj2 and V1rj3 are sensitive to two sulfated estrogens (SEs) and can be activated by a broad variety of sulfated and glucuronidated steroids at high concentrations. Steroids 146-154 vomeronasal 1 receptor 85 Mus musculus 23-28 25976424-1 2015 Kisspeptin neurones located in the arcuate nucleus (ARC) and preoptic area (POA) are critical mediators of gonadal steroid feedback onto gonadotrophin-releasing hormone (GnRH) neurones. Steroids 115-122 KiSS-1 metastasis-suppressor Mus musculus 0-10 25904015-2 2015 Steroid hormone-responsive tissues express multiple KLFs that are linked to progesterone receptor (PGR) and estrogen receptor (ESR) actions either as integrators or as coregulators. Steroids 0-15 progesterone receptor Mus musculus 76-97 25904015-2 2015 Steroid hormone-responsive tissues express multiple KLFs that are linked to progesterone receptor (PGR) and estrogen receptor (ESR) actions either as integrators or as coregulators. Steroids 0-15 progesterone receptor Mus musculus 99-102 25349066-7 2015 In multivariate logistic regression including age, ethnicity, HCV, tacrolimus level and pulsed steroids, only DCD was independently associated with NODAT at day 15 post-transplant (OR 6.5, 95% CI 2.3-18.4, P < 0.001), whereas age and pulsed steroids were significant factors between 30-90 days. Steroids 244-252 dermcidin Homo sapiens 110-113 26008782-1 2015 BACKGROUND: Hepatic 3beta-hydroxysteroid dehydrogenase (3beta-HSD) plays an important role in steroid inactivation and catabolism. Steroids 33-40 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 56-65 25503463-6 2015 With this report, we emphasize that high blood levels of adrenal steroid precursors may cross-react with aldosterone and lead to confusing laboratory results that prevent making the accurate differential diagnosis between CAH and PHA1. Steroids 65-72 sodium channel epithelial 1 subunit gamma Homo sapiens 230-234 25291985-9 2015 Steroid treatment reduced inflammation and MCp influx but had no effect on established MMCs. Steroids 0-7 CD46 antigen, complement regulatory protein Mus musculus 43-46 25947291-7 2015 The conversion of LBHB to an ordinary hydrogen bond in the mutant KSI reduced the binding affinity for the steroid inhibitors by a factor of 8.1-11. Steroids 107-114 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 66-69 25847799-0 2015 Two Case Reports of Successful Treatment of Cholestasis With Steroids in Patients With PFIC-2. Steroids 61-69 ATP binding cassette subfamily B member 11 Homo sapiens 87-93 25847799-3 2015 We report on a young woman and a boy who clinically presented with PFIC-2 phenotypes and dramatically improved with steroid treatment. Steroids 116-123 ATP binding cassette subfamily B member 11 Homo sapiens 67-73 25847799-14 2015 In conclusion, the clinical courses suggest that patients with BSEP deficiency and residual BSEP activity may benefit from steroid-based therapy, which represents a new treatment option. Steroids 123-130 ATP binding cassette subfamily B member 11 Homo sapiens 63-67 25576487-1 2015 The steroid pregnenolone sulfate activates the transcription factor activator protein-1 (AP-1) via stimulation of transient receptor potential melastatin-3 (TRPM3) channels. Steroids 4-11 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 68-87 25576487-1 2015 The steroid pregnenolone sulfate activates the transcription factor activator protein-1 (AP-1) via stimulation of transient receptor potential melastatin-3 (TRPM3) channels. Steroids 4-11 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 89-93 25721668-1 2015 The constitutive androstane receptor (CAR) plays a key role in the expression of xenobiotic/steroid and drug metabolizing enzymes and their transporters. Steroids 92-99 nuclear receptor subfamily 1 group I member 3 Homo sapiens 38-41 26045751-0 2015 Co-expression of CXCR4 and CXCR7 in human endometrial stromal cells is modulated by steroid hormones. Steroids 84-100 C-X-C motif chemokine receptor 4 Homo sapiens 17-22 26045751-0 2015 Co-expression of CXCR4 and CXCR7 in human endometrial stromal cells is modulated by steroid hormones. Steroids 84-100 atypical chemokine receptor 3 Homo sapiens 27-32 26045751-6 2015 Thus, ESCs spatiotemporally co-express CXCR4 and CXCR7 rather than CXCL12, and E and P are able to regulate the expression of CXCR4 and CXCR7 in ESCs, suggesting the modulation of steroid hormones on chemokine receptor expression in ESCs. Steroids 180-196 C-X-C motif chemokine receptor 4 Homo sapiens 126-131 26045751-6 2015 Thus, ESCs spatiotemporally co-express CXCR4 and CXCR7 rather than CXCL12, and E and P are able to regulate the expression of CXCR4 and CXCR7 in ESCs, suggesting the modulation of steroid hormones on chemokine receptor expression in ESCs. Steroids 180-196 atypical chemokine receptor 3 Homo sapiens 136-141 25392269-6 2015 Steroids modulated multifunctional genes, up-regulating genes important in repair and aging [angiopoietin-like 4 (ANGPTL4), chemokine (C-X-C motif) ligand 1 (CXCL1), lamin B1 (LMNB1), and thioredoxin interacting protein (TXNIP)]. Steroids 0-8 C-X-C motif chemokine ligand 1 Homo sapiens 158-163 25765798-3 2015 Treatment of ITP has been changed dramatically by the application of thrombopoietin receptor agonists, TPO-RAs, in patients unresponsive to traditional steroids and splenectomy. Steroids 152-160 thyroid peroxidase Homo sapiens 103-106 25767807-5 2015 In this work, we used the mouse mammary gland cell line EpH4, in which we controlled AQP5 expression via the steroid hormone dexamethasone (Dex) to further investigate mechanisms regulating AQP5 expression. Steroids 109-124 aquaporin 5 Mus musculus 85-89 25546479-8 2015 Mean VEGF levels were 794.46 pg/mL, 777.91 pg/mL and 872 pg/mL for IVB, steroid and control groups, respectively (p = 0.002, p = 0.019 and p = 0.014). Steroids 72-79 vascular endothelial growth factor A Oryctolagus cuniculus 5-9 25132599-0 2015 Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. Steroids 77-84 tryptophan 2,3-dioxygenase Homo sapiens 15-18 25132599-10 2015 In summary, we identify a novel steroid-responsive FKBP52-dependent pathway suppressing the expression and activity of TDO, a central and rate-limiting enzyme in tryptophan metabolism, in human gliomas. Steroids 32-39 tryptophan 2,3-dioxygenase Homo sapiens 119-122 25437815-7 2015 Patients with high expression of HSPA4 or Bmi1 showed significantly lower response rates upon subsequent steroid therapy as compared with patients with low expression of each gene. Steroids 105-112 heat shock protein family A (Hsp70) member 4 Homo sapiens 33-38 26064112-10 2015 These results suggest that C/EBPbeta isoforms expression changes in a tissue-specific manner in the rat brain due to the changes in sex steroid hormone levels presented during the estrous cycle. Steroids 136-151 CCAAT/enhancer binding protein beta Rattus norvegicus 27-36 25091424-3 2015 Mutations in eight of them (PDSS1, PDSS2, COQ2, COQ4, COQ6, ADCK3, ADCK4, and COQ9) cause primary CoQ(10) deficiency, a heterogeneous group of disorders with variable age of onset (from birth to the seventh decade) and associated clinical phenotypes, ranging from a fatal multisystem disease to isolated steroid resistant nephrotic syndrome (SRNS) or isolated central nervous system disease. Steroids 304-311 coenzyme Q4 Homo sapiens 48-52 25263657-6 2015 In the current study we examined effects of estrogens on steroid metabolism catalyzed by CYP7B1 and other enzymes in primary cultures of rat astrocytes. Steroids 57-64 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 89-95 25263657-9 2015 In addition, our present experiments on catalytic steroid conversions revealed that estrogens significantly suppress the CYP7B1-catalyzed metabolism of not only DHEA but also of pregnenolone and 27-hydroxycholesterol in rat astrocytes. Steroids 50-57 cytochrome P450 family 7 subfamily B member 1 Rattus norvegicus 121-127 25612870-3 2015 The gonadal steroid 17beta-estradiol (E2) upregulates not only kisspeptin (Kiss1) mRNA but also increases the excitability of the rostral forebrain Kiss1 neurons. Steroids 12-19 KiSS-1 metastasis suppressor Homo sapiens 75-80 25612870-3 2015 The gonadal steroid 17beta-estradiol (E2) upregulates not only kisspeptin (Kiss1) mRNA but also increases the excitability of the rostral forebrain Kiss1 neurons. Steroids 12-19 KiSS-1 metastasis suppressor Homo sapiens 148-153 26689006-0 2015 [Hormone-sensitive lipase/cholesteryl esterase from the adrenal cortex - structure, regulation and role in steroid hormone synthesis]. Steroids 107-122 lipase E, hormone sensitive type Homo sapiens 1-25 25511299-7 2014 We find that E75 protects rhythms under stressful conditions, suggesting a function for steroid signalling in the maintenance of circadian rhythms in Drosophila. Steroids 88-95 Ecdysone-induced protein 75B Drosophila melanogaster 13-16 25460299-4 2014 In addition to this primary genetic form, there are other forms of TMAU that support the hypothesis that FMO3 activity may be modulated by steroid hormones. Steroids 139-155 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 105-109 25460299-5 2014 To understand the molecular mechanism involved in the regulation of Fmo3 gene expression by steroid hormones, we performed this study in an in vitro cellular system, mouse liver cells, and on the human FMO3 gene. Steroids 92-108 flavin containing dimethylaniline monoxygenase 3 Homo sapiens 202-206 25179180-2 2014 In the present study, we examined androgen receptor (AR)-mediated actions of testicular steroids in the regulation of adrenocortical function in the sand rat. Steroids 88-96 androgen receptor Rattus norvegicus 34-51 25179180-2 2014 In the present study, we examined androgen receptor (AR)-mediated actions of testicular steroids in the regulation of adrenocortical function in the sand rat. Steroids 88-96 androgen receptor Rattus norvegicus 53-55 25157097-3 2014 Also, hSULT2A1 functions in the metabolism of steroid hormones such as dehydroepiandrosterone (DHEA) and pregnenolone (PREG). Steroids 46-62 sulfotransferase family 2A member 1 Homo sapiens 6-14 25157097-4 2014 These roles of hSULT2A1 in steroid hormone metabolism and in generating a reactive metabolite of tamoxifen led us to examine its interactions with tamoxifen and several of its major metabolites. Steroids 27-42 sulfotransferase family 2A member 1 Homo sapiens 15-23 25145395-3 2014 We generated a steroid-inducible ARF5/MONOPTEROS (MP) transgenic background to survey the involvement of this factor in the transcriptional regulation of the entire Aux/IAA family in Arabidopsis thaliana. Steroids 15-22 Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein Arabidopsis thaliana 33-37 25309465-3 2014 Interestingly, alterations in levels of estrogen, another steroid hormone, may play a role in depressive-like behavior in postpartum females with fluctuations of BDNF-related molecules in the brain. Steroids 58-73 brain derived neurotrophic factor Homo sapiens 162-166 25209682-3 2014 Here we show that expression of the cytochrome P450 DAF-9/CYP450 and production of the steroid hormone Delta(7)-dafachronic acid (DA) are increased in C. elegans subjected to DR. DA signalling through the non-canonical nuclear hormone receptor NHR-8/NHR and the nutrient-responsive kinase let-363/mTOR is essential for DR-mediated longevity. Steroids 87-102 Target of rapamycin homolog Caenorhabditis elegans 289-296 25209682-5 2014 These data demonstrate that steroid signalling links germline physiology to lifespan when nutrients are limited, and establish a central role for let-363/mTOR in integrating signals derived from nutrients and steroid hormones. Steroids 209-225 Target of rapamycin homolog Caenorhabditis elegans 146-153 24800894-11 2014 CONCLUSIONS: We conclude that the inhibition of peripheral CaV3.2 T-channels contributes to the potent analgesic effect of the endogenous steroid epipregnanolone. Steroids 138-145 calcium channel, voltage-dependent, T type, alpha 1H subunit Mus musculus 59-65 25001952-2 2014 Substantial research has demonstrated that anxiety is associated with sympathetic activation, while sex steroid hormones have been shown to exert differential actions in regulating BDNF expression. Steroids 104-120 brain derived neurotrophic factor Homo sapiens 181-185 24728488-10 2014 In particular, UGT5A5, UGT5B2, and UGT5E1 glucuronidate phenols and steroids with high specificity toward steroid hormones of estradiol and testosterone and estrogenic alkylphenols 4-tert-octylphenol. Steroids 68-76 UDP glucuronosyltransferase 5 family, polypeptide B2 Danio rerio 23-29 24728488-10 2014 In particular, UGT5A5, UGT5B2, and UGT5E1 glucuronidate phenols and steroids with high specificity toward steroid hormones of estradiol and testosterone and estrogenic alkylphenols 4-tert-octylphenol. Steroids 106-122 UDP glucuronosyltransferase 5 family, polypeptide B2 Danio rerio 23-29 24709674-12 2014 Thus, nicotine-mediated reduction of SF-1 expression resulted in an inhibitory effect on the expression of its target genes and steroid production via histone deacetylation. Steroids 128-135 splicing factor 1 Homo sapiens 37-41 24982636-2 2014 In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR) interacts with its ligand 1alpha,25(OH)2D3 to modulate the normal mammary epithelial cell genome and subsequent phenotype. Steroids 37-44 vitamin D receptor Homo sapiens 101-119 24982636-2 2014 In addition to receptors for classic steroid hormones such as estrogen and progesterone, the nuclear vitamin D receptor (VDR) interacts with its ligand 1alpha,25(OH)2D3 to modulate the normal mammary epithelial cell genome and subsequent phenotype. Steroids 37-44 vitamin D receptor Homo sapiens 121-124 24631866-8 2014 5TG modified patterns of steroid feedback-associated Fos staining of A2, but not other medullary catecholamine cell groups. Steroids 25-32 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 53-56 24650456-3 2014 In addition, steroid hormones have been shown to affect Th1/Th2 balance, particularly in autoimmune diseases. Steroids 13-29 negative elongation factor complex member C/D Homo sapiens 56-59 24992763-0 2014 Huogu I formula prevents steroid-induced osteonecrosis in rats by down-regulating PPARgamma expression and activating wnt/LRP5/ beta-catenin signaling. Steroids 25-32 peroxisome proliferator-activated receptor gamma Rattus norvegicus 82-91 24586073-3 2014 Using in vitro human ESCs model, we previously showed that activation of a cAMP mediator, exchange protein directly activated by cAMP (EPAC), promotes ovarian steroid- or cAMP analog-induced decidualization. Steroids 159-166 Rap guanine nucleotide exchange factor 3 Homo sapiens 135-139 24347461-11 2014 Conversely, steroids enhanced IL-17A levels, and therefore any steroid-sparing properties of vitamin D may have additional benefit in STRA. Steroids 12-20 interleukin 17A Homo sapiens 30-36 24347461-11 2014 Conversely, steroids enhanced IL-17A levels, and therefore any steroid-sparing properties of vitamin D may have additional benefit in STRA. Steroids 12-19 interleukin 17A Homo sapiens 30-36 24885856-1 2014 BACKGROUND: We have shown that chronic obstructive pulmonary disease (COPD) is associated with increased production of pro-inflammatory cytokines and the cytotoxic mediator, granzyme B by peripheral blood steroid resistant CD28nullCD137 + CD8+ T cells and granzyme B by NKT-like and NK cells. Steroids 205-212 CD8a molecule Homo sapiens 239-242 24856380-0 2014 Retrospective mutational analysis of NPHS1, NPHS2, WT1 and LAMB2 in children with steroid-resistant focal segmental glomerulosclerosis - a single-centre experience. Steroids 82-89 NPHS1 adhesion molecule, nephrin Homo sapiens 37-42 24760864-10 2014 These animals also exhibited a compromised positive feedback response to sex steroids, as shown by significantly lower Kiss1 mRNA levels in the AVPV, compared with Lepr(lox/lox) mice. Steroids 77-85 KiSS-1 metastasis-suppressor Mus musculus 119-124 24369117-0 2014 Silencing diacylglycerol kinase-theta expression reduces steroid hormone biosynthesis and cholesterol metabolism in human adrenocortical cells. Steroids 57-72 diacylglycerol kinase theta Homo sapiens 10-37 24767350-12 2014 Patients with higher bile CXCL10 levels suffered from severe acute cellular rejection that was refractory to steroid pulse. Steroids 109-116 C-X-C motif chemokine ligand 10 Homo sapiens 26-32 24361722-5 2014 We hypothesized that the beneficial effect of steroids on eosinophilic meningitis is partially mediated by the down-regulation of 14-3-3beta protein expression in the cerebrospinal fluid (CSF). Steroids 46-54 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide Mus musculus 130-140 24428972-0 2014 Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics. Steroids 79-86 leukotriene B4 receptor Homo sapiens 0-25 23807211-10 2014 Ten genes have been successfully validated involved in: (1) steroid hormone secretion (HSD3B1, HSD3B2), (2) retinoic acid signaling (ABCA1, ABCG1, HMGCR), (3) cell-cycle damage (GADD45A, CCNE2, UHRF1), and the (4) immune response (MAP2K6, IL1R2). Steroids 60-75 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 87-93 23807211-10 2014 Ten genes have been successfully validated involved in: (1) steroid hormone secretion (HSD3B1, HSD3B2), (2) retinoic acid signaling (ABCA1, ABCG1, HMGCR), (3) cell-cycle damage (GADD45A, CCNE2, UHRF1), and the (4) immune response (MAP2K6, IL1R2). Steroids 60-75 ATP binding cassette subfamily A member 1 Homo sapiens 133-138 23807211-10 2014 Ten genes have been successfully validated involved in: (1) steroid hormone secretion (HSD3B1, HSD3B2), (2) retinoic acid signaling (ABCA1, ABCG1, HMGCR), (3) cell-cycle damage (GADD45A, CCNE2, UHRF1), and the (4) immune response (MAP2K6, IL1R2). Steroids 60-75 ubiquitin like with PHD and ring finger domains 1 Homo sapiens 194-199 23920215-2 2014 Aerosolized medications such as inhaled steroids and beta agonists are commonly administered in-line through nasal CPAP, especially to infants with bronchopulmonary dysplasia. Steroids 40-48 centromere protein J Homo sapiens 115-119 24489989-5 2014 Moreover, analysis of the uterine phenotypes of ERalpha/ERbeta and PRA/PRB knockout mice indicates that different ER subtypes and PR isoforms mediate distinct responses to steroid hormones and play different roles in uterine function. Steroids 172-188 progesterone receptor Mus musculus 71-74 24328079-2 2014 Structure-activity studies of ent-steroid potentiators of gamma-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Steroids 34-41 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 58-88 24328079-7 2014 The results indicate that ent-steroids have considerable potential to be developed as anesthetic agents and as drugs to treat brain disorders that are ameliorated by positive allosteric modulators of GABAA receptor function. Steroids 30-38 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 200-205 24400704-3 2014 In this research, we investigate the experience of NSP workers who come into contact with people who use steroids and other performance- and image-enhancing drugs (PIED). Steroids 105-113 sperm antigen with calponin homology and coiled-coil domains 1 Homo sapiens 51-54 23912843-0 2014 Neonatal steroids induce a down-regulation of tenascin-C and elastin and cause a deceleration of the first phase and an acceleration of the second phase of lung alveolarization. Steroids 9-17 tenascin C Homo sapiens 46-56 23912843-0 2014 Neonatal steroids induce a down-regulation of tenascin-C and elastin and cause a deceleration of the first phase and an acceleration of the second phase of lung alveolarization. Steroids 9-17 elastin Homo sapiens 61-68 23912843-9 2014 A short course of neonatal steroids impairs the first phase of alveolarization, most likely by altering the TNC and elastin expression. Steroids 27-35 tenascin C Homo sapiens 108-111 23912843-9 2014 A short course of neonatal steroids impairs the first phase of alveolarization, most likely by altering the TNC and elastin expression. Steroids 27-35 elastin Homo sapiens 116-123 24862278-4 2014 Steroid hormones play an essential role in the growth of a variety of cancers and have been shown to increase the expression and activity of several lipogenic factors, including fatty acid synthase and sterol regulatory element-binding proteins. Steroids 0-16 fatty acid synthase Homo sapiens 178-197 24821192-1 2014 BACKGROUND: Ovarian steroids regulate sexual receptivity in the female rat by acting on neurons that converge on proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). Steroids 20-28 proopiomelanocortin Rattus norvegicus 113-132 24821192-1 2014 BACKGROUND: Ovarian steroids regulate sexual receptivity in the female rat by acting on neurons that converge on proopiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). Steroids 20-28 proopiomelanocortin Rattus norvegicus 134-138 24211850-3 2014 The most likely cause of these changes is provided by the stress initiated release of steroids, which readily enter neurons and alter gene expression, for example that of BDNF. Steroids 86-94 brain derived neurotrophic factor Homo sapiens 171-175 24211850-6 2014 Although present evidence points to changes in BDNF transcription being the major causal agent for the changes in spine density in different parts of the brain following stress, steroids have significant effects on downstream pathways from the TrkB receptor once it is acted upon by BDNF, including those that modulate the density of dendritic spines. Steroids 178-186 brain derived neurotrophic factor Homo sapiens 283-287 23988737-1 2013 Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads. Steroids 56-63 sulfotransferase family 2A member 1 Homo sapiens 32-37 23988737-5 2013 The fact, however, that steroid sulfatase mRNA was not detected in the GC-2 cells and the clear demonstration of DHEAS-induced activation of Erk1/2, ATF-1 and CREB after silencing the androgen receptor by small interfering RNA (siRNA) clearly contradict this assumption and make it appear unlikely that DHEAS has to be converted in the cytosol into a different steroid in order to activate the kinases and transcription factors mentioned. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 113-118 23988737-6 2013 Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 31-36 23988737-6 2013 Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 269-274 23988737-6 2013 Instead, it is likely that the DHEAS-induced signaling is mediated through the interaction of the steroid with a membrane-bound G-protein-coupled receptor, since silencing of Guanine nucleotide-binding protein subunit alpha-11 (Gnalpha11) leads to the abolition of the DHEAS-induced stimulation of Erk1/2, ATF-1, and CREB. Steroids 98-105 cAMP responsive element binding protein 1 Homo sapiens 317-321 24021943-2 2013 We hypothesized that we could target these steroid-resistant lymphocytes by inhibiting costimulation through CD137. Steroids 43-50 TNF receptor superfamily member 9 Homo sapiens 109-114 23942012-1 2013 TSPO mediated transport of cholesterol into the mitochondrion is a necessary step in steroid synthesis. Steroids 85-92 translocator protein Homo sapiens 0-4 24355240-4 2013 After analyzing a series of cases and the recent literature suggesting that glucocorticoids may down-regulate the elastin gene expression and elastin mRNA, in cultured human skin fibroblasts, we think that high dose and prolonged steroid therapy may contribute to the appearance of PXE-PDE lesions. Steroids 230-237 elastin Homo sapiens 114-121 24355240-4 2013 After analyzing a series of cases and the recent literature suggesting that glucocorticoids may down-regulate the elastin gene expression and elastin mRNA, in cultured human skin fibroblasts, we think that high dose and prolonged steroid therapy may contribute to the appearance of PXE-PDE lesions. Steroids 230-237 elastin Homo sapiens 142-149 23907384-1 2013 Steroidogenic Factor-1 (SF-1) is a nuclear receptor that has a pivotal role in the development of adrenal glands and gonads and in the control of steroid hormone production, being also implicated in the pathogenesis of adrenocortical tumors. Steroids 146-161 splicing factor 1 Homo sapiens 0-28 23904514-8 2013 Under ovarian steroid stimulation, IL-15 was detectable on the surface, but not in the supernatant, of cultured HUtMVECs. Steroids 14-21 interleukin 15 Homo sapiens 35-40 23904514-9 2013 Ovarian steroid-induced IL-15 expression on HUtMVECs was not attenuated by chondroitinase ABC (which degrades chondroitin sulfate-A and -C and dermatan sulfate) or sodium acetate buffer (which dissociates cytokines from their cognate receptors). Steroids 8-15 interleukin 15 Homo sapiens 24-29 23904514-11 2013 Instead, HUtMVECs bear a membrane-bound form IL-15 under the influence of ovarian steroids, which may be favorable for preventing downregulation of CD62L on PB CD16(-) NK cells and facilitating their initial contact with HUtMVECs. Steroids 82-90 ATP binding cassette subfamily A member 1 Homo sapiens 25-39 23904514-11 2013 Instead, HUtMVECs bear a membrane-bound form IL-15 under the influence of ovarian steroids, which may be favorable for preventing downregulation of CD62L on PB CD16(-) NK cells and facilitating their initial contact with HUtMVECs. Steroids 82-90 interleukin 15 Homo sapiens 45-50 23904514-11 2013 Instead, HUtMVECs bear a membrane-bound form IL-15 under the influence of ovarian steroids, which may be favorable for preventing downregulation of CD62L on PB CD16(-) NK cells and facilitating their initial contact with HUtMVECs. Steroids 82-90 Fc gamma receptor IIIa Homo sapiens 160-164 24058506-6 2013 In addition, we identified significant associations between three CpG sites (~1%) and sex, including DNA methylation in CASP6, a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone. Steroids 212-227 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 182-190 23731524-3 2013 Calcineurin-inhibitor based steroid-containing regimens have been the mainstay of maintenance immunosuppression over the last two decades. Steroids 28-35 calcineurin binding protein 1 Homo sapiens 0-21 23744642-2 2013 Arcuate neurons coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons) are steroid-sensitive and have been postulated to both generate GnRH pulses and mediate steroid feedback on pulse frequency. Steroids 94-101 KiSS-1 metastasis-suppressor Mus musculus 29-39 23744642-2 2013 Arcuate neurons coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons) are steroid-sensitive and have been postulated to both generate GnRH pulses and mediate steroid feedback on pulse frequency. Steroids 178-185 KiSS-1 metastasis-suppressor Mus musculus 29-39 23683514-2 2013 We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10. Steroids 27-34 interleukin 10 Homo sapiens 190-195 23683514-2 2013 We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10. Steroids 132-140 interleukin 10 Homo sapiens 190-195 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 206-214 interleukin 17A Homo sapiens 84-90 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 206-214 interleukin 22 Homo sapiens 95-100 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 272-280 interleukin 17A Homo sapiens 84-90 23683514-3 2013 OBJECTIVE: We sought to investigate the production of the TH17-associated cytokines IL-17A and IL-22 in culture in patients with moderate-to-severe asthma defined on the basis of their clinical response to steroids and the susceptibility of this response to inhibition by steroids and the active form of vitamin D, 1alpha,25-dihydroxyvitamin D3 (1,25[OH]2D3). Steroids 272-280 interleukin 22 Homo sapiens 95-100 22522787-1 2013 The multidrug resistance-associated protein1 (MRP1/ABCC1) is a member of the ABCC transporter subfamily that mediates the efflux of pharmaceuticals, xenobiotics and steroid hormones, typically as glutathione, glucuronide or sulfate conjugates. Steroids 165-181 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 4-44 22522787-1 2013 The multidrug resistance-associated protein1 (MRP1/ABCC1) is a member of the ABCC transporter subfamily that mediates the efflux of pharmaceuticals, xenobiotics and steroid hormones, typically as glutathione, glucuronide or sulfate conjugates. Steroids 165-181 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 46-50 22522787-1 2013 The multidrug resistance-associated protein1 (MRP1/ABCC1) is a member of the ABCC transporter subfamily that mediates the efflux of pharmaceuticals, xenobiotics and steroid hormones, typically as glutathione, glucuronide or sulfate conjugates. Steroids 165-181 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 51-56 22522787-6 2013 In the small intestine, there were interactions between steroid hormone levels and genotype, as the expression differences were only found in mice lacking Mrp1, and were changed between intact and castrated animals. Steroids 56-71 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 155-159 23689136-3 2013 To determine the molecular pathways that mediate the distinct effects of T and DHT, we studied the expression of the liver receptor homolog 1 (LRH-1) gene, which is differentially regulated by these steroids. Steroids 199-207 nuclear receptor subfamily 5, group A, member 2 Rattus norvegicus 117-141 23689136-3 2013 To determine the molecular pathways that mediate the distinct effects of T and DHT, we studied the expression of the liver receptor homolog 1 (LRH-1) gene, which is differentially regulated by these steroids. Steroids 199-207 nuclear receptor subfamily 5, group A, member 2 Rattus norvegicus 143-148 23239819-3 2013 It has been demonstrated that adiponectin may reduce gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus as well as modulate gonadal steroid hormone production. Steroids 151-166 adiponectin, C1Q and collagen domain containing Rattus norvegicus 30-41 23768053-9 2013 Numerous genes were up- or down-regulated by more than twofold by steroid treatment, including proinflammatory interleukins (IL-16) and anti-inflammatory cytokines. Steroids 66-73 interleukin 16 Mus musculus 125-130 23467054-8 2013 The odds of the development of PWMI significantly increased with increasing levels of GFAP from day 1-4 of life when adjustment was made for preeclampsia, antenatal steroid administration, and neonatal chronic lung disease. Steroids 165-172 glial fibrillary acidic protein Homo sapiens 86-90 23809625-5 2013 In addition, Kiss1 neurons in the brain are targets and transmitters of the regulatory actions of sex steroids and metabolic cues on the reproductive axis during early organizing periods and adulthood. Steroids 102-110 KiSS-1 metastasis suppressor Homo sapiens 13-18 23636810-10 2013 These findings suggest that switching of the expression of FSHR to LHR controls the effects of FSH and/or LH on vitellogenesis and final oocyte maturation via steroid production in granulosa and thecal cells. Steroids 159-166 follicle stimulating hormone receptor Homo sapiens 59-63 23308012-0 2013 Modulation of the expression of the transcription factors T-bet and GATA-3 in immortalized human endometrial stromal cells (HESCs) by sex steroid hormones and cAMP. Steroids 138-154 GATA binding protein 3 Homo sapiens 68-74 23308012-4 2013 The objective of this study was to examine the modulation of the gene expression of T-bet and GATA-3, and of the cytokines interferon gamma (IFN-gamma) and interleukin 4 (IL-4), by female steroid hormones, in human endometrial stromal cells (HESC) in long-term cultures (30 days) mimicking the normal menstrual cycle. Steroids 188-204 GATA binding protein 3 Homo sapiens 94-100 23417422-9 2013 The percentage of estrogen receptor neurons containing Fos was significantly influenced in a brain region-, developmental stage-, and steroid-specific fashion by testosterone and E2 treatments. Steroids 134-141 protein c-Fos Ovis aries 55-58 23362264-9 2013 Cells overexpressing HSL increased the efficacy of liver X receptor (LXR) ligands on StAR expression and steroid synthesis, suggesting HSL-mediated steroidogenesis entails enhanced oxysterol production. Steroids 105-112 lipase, hormone sensitive Mus musculus 21-24 23548522-12 2013 CONCLUSION: VEGF blockage may provide adjunctive therapeutic options as steroid-sparing agents for more effective treatment of remodeling in asthma. Steroids 72-79 vascular endothelial growth factor A Mus musculus 12-16 23768637-9 2013 l-asparaginase-containing regimens such as SMILE (steroid, methotrexate, ifosfamide, l-asparaginase, and etoposide) are effective for ENKL. Steroids 50-57 transmembrane O-mannosyltransferase targeting cadherins 3 Homo sapiens 43-48 23386646-9 2013 RESULTS: AV levels of DHEA-S were the highest among the steroids measured. Steroids 56-64 sulfotransferase family 2A member 1 Homo sapiens 22-28 23320515-6 2013 The analysis of the metabolic pathway and the metabolic ratio of steroids enabled the estimation of the induction of CYP1A/3A/7B/11B/2C and the inhibition of CYP17A/19A in response to PXR activation. Steroids 65-73 SLAM family member 7 Homo sapiens 165-168 23429294-1 2013 The sex steroid hormone 17beta-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Steroids 8-23 neuroglobin Homo sapiens 72-83 23429294-1 2013 The sex steroid hormone 17beta-estradiol (E2) upregulates the levels of neuroglobin (NGB), a new neuroprotectant globin, to elicit its neuroprotective effect against H(2)O(2)-induced apoptosis. Steroids 8-23 neuroglobin Homo sapiens 85-88 23379382-0 2013 Interleukin-6, vascular endothelial growth factor and transforming growth factor beta 1 in canine steroid responsive meningitis-arteritis. Steroids 98-105 interleukin 6 Canis lupus familiaris 0-13 23550014-6 2013 Thus, kisspeptin neurons are capable of burst firing, and their activity is modulated by sex steroids and other regulatory factors. Steroids 93-101 KiSS-1 metastasis-suppressor Mus musculus 6-16 23509787-0 2013 Differential expression of Na+/H+-exchanger (NHE-1, 2, and 4) proteins and mRNA in rodent"s uterus under sex steroid effect and at different phases of the oestrous cycle. Steroids 109-116 solute carrier family 9 member A1 Rattus norvegicus 45-60 22728025-5 2013 In addition, sex steroids can also impart activational (temporary) effects on kisspeptin neurons and Kiss1 gene expression at various times during neonatal and peripubertal development, as they do in adulthood. Steroids 17-25 KiSS-1 metastasis suppressor Homo sapiens 101-106 23095516-2 2013 We hypothesized that the uterus in pigs possesses active 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. Steroids 206-214 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 57-119 23095516-2 2013 We hypothesized that the uterus in pigs possesses active 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. Steroids 206-214 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 121-130 23095516-2 2013 We hypothesized that the uterus in pigs possesses active 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. Steroids 70-77 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 121-130 23095516-2 2013 We hypothesized that the uterus in pigs possesses active 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. Steroids 314-322 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 57-119 23095516-2 2013 We hypothesized that the uterus in pigs possesses active 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase (3beta-HSD) responsible for progesterone and androstenedione production, that uterine steroids may supplement the amount of steroid hormones produced by embryos and corpus luteum and that these steroids are necessary for maintenance of pregnancy. Steroids 314-322 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Sus scrofa 121-130 23000191-4 2013 In this study, we determined the effects of transactivation of three nuclear receptors, the constitutive androstane receptor (CAR), pregnane X receptor (PXR), and farnesoid X receptor (FXR), on gene expression and steroid hormone metabolism in primary porcine Leydig cells. Steroids 214-229 nuclear receptor subfamily 1 group I member 3 Sus scrofa 92-124 23555666-8 2013 In pchMR transfected HCT116, aldosterone or natural serum steroids largely inhibited mRNA expression levels of both VEGFA and its receptor 2/KDR. Steroids 58-66 kinase insert domain receptor Homo sapiens 141-144 23080515-1 2012 The 18 kDa translocator protein (TSPO) is a primarily mitochondrial protein that participates in steroid biosynthesis, cell proliferation, differentiation, apoptosis, and the regulation of mitochondrial function in general. Steroids 97-104 translocator protein Homo sapiens 11-31 23080515-1 2012 The 18 kDa translocator protein (TSPO) is a primarily mitochondrial protein that participates in steroid biosynthesis, cell proliferation, differentiation, apoptosis, and the regulation of mitochondrial function in general. Steroids 97-104 translocator protein Homo sapiens 33-37 22845879-2 2012 Sex steroid hormones are also involved in the regulation of brain-derived neurotrophic factor expression. Steroids 4-20 brain derived neurotrophic factor Homo sapiens 60-93 22845879-3 2012 A review of the literature is provided on the relationship between brain-derived neurotrophic factor and sex steroid hormones, as well as the mechanisms behind this interaction, in the context of how this relationship may be involved in the development of neurodevelopmental psychiatric illnesses, such as schizophrenia and depression. Steroids 109-116 brain derived neurotrophic factor Homo sapiens 67-100 22921020-2 2012 This steroid response appears to be heritable and alleles in the SFRS3 and FKBP4 genes have recently been suggested to play a role. Steroids 5-12 serine and arginine rich splicing factor 3 Homo sapiens 65-70 22921020-3 2012 The purpose of the present study was to perform an independent replication study to determine whether single nucleotide polymorphisms (SNPs) in SFRS3 and FKBP4 are involved in the steroid response. Steroids 180-187 serine and arginine rich splicing factor 3 Homo sapiens 144-149 22982504-1 2012 Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. Steroids 16-23 sulfotransferase family 2A member 1 Homo sapiens 171-176 22982504-1 2012 Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis. Steroids 16-31 sulfotransferase family 2A member 1 Homo sapiens 171-176 22874434-3 2012 In contrast to AKR1B10 and AKR1B2, AKR1B19 efficiently reduced 3-keto-5alpha/beta-dihydro-C19/C21/C24-steroids into the corresponding 3beta-hydroxysteroids, showing K(m) of 1.3-9.1 muM and k(cat) of 1.1-7.6 min(-1). Steroids 102-110 aldo-keto reductase family 1 member B10 Oryctolagus cuniculus 15-22 22962256-2 2012 The ovarian sex steroid hormones 17beta-estradiol (E(2)) and progesterone (P(4)) have been shown to regulate Abeta accumulation, although the underlying mechanism(s) remain to be fully elucidated. Steroids 16-23 amyloid beta precursor protein Rattus norvegicus 109-114 22639106-8 2012 Recent studies, however, have identified that L-asparaginase-containing regimens, such as SMILE (steroid, methotrexate, ifosfamide, L-asparaginase and etoposide), are effective for ENKL. Steroids 97-104 transmembrane O-mannosyltransferase targeting cadherins 3 Homo sapiens 90-95 22884782-7 2012 In CTCL, the numbers of CD163(+) or CD68(+) cells increased as more tumor cells infiltrated and they decreased after treatment with topical steroid and ultraviolet light. Steroids 140-147 CD163 molecule Homo sapiens 24-29 22798350-9 2012 Thus, GC FGF9 gene expression is hormonally regulated, and FGF9 may act as an autocrine regulator of ovarian function by slowing follicular differentiation via inhibiting IGF-I action, gonadotropin receptors, the cAMP signaling cascade, and steroid synthesis while stimulating GC proliferation in cattle. Steroids 241-248 fibroblast growth factor 9 Bos taurus 59-63 21975377-9 2012 CONCLUSIONS: The ApaI SNP of the VDR gene was associated with PP in the studied population and may modulate ovarian steroid secretion in these girls. Steroids 116-123 vitamin D receptor Homo sapiens 33-36 28726217-9 2012 CONCLUSIONS: The ApaI SNP of the VDR gene was associated with PP in the studied population and may modulate ovarian steroid secretion in these girls. Steroids 116-123 vitamin D receptor Homo sapiens 33-36 22645323-7 2012 CONCLUSIONS: A regimen of early intensified EC-MPS dosing with calcineurin inhibitor and IL-2RA induction permits oral steroid avoidance in adult kidney transplant patients at low-immunological risk without compromising efficacy at 6 months" follow-up. Steroids 119-126 calcineurin binding protein 1 Homo sapiens 63-84 22564661-1 2012 We set out to describe an efficient and versatile method for preparing pentacyclic steroids diversely substituted at C-11 from cholic acid, via a stereoselective epoxidation and the epoxide opening as the key steps. Steroids 83-91 RNA polymerase III subunit K Homo sapiens 117-121 22371261-2 2012 Steroid induction of the UGT1A1 gene indicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), may underlie the induction process. Steroids 0-7 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 25-31 22371261-2 2012 Steroid induction of the UGT1A1 gene indicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), may underlie the induction process. Steroids 0-7 nuclear receptor subfamily 1, group I, member 2 Mus musculus 84-103 22371261-2 2012 Steroid induction of the UGT1A1 gene indicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), may underlie the induction process. Steroids 0-7 nuclear receptor subfamily 1, group I, member 2 Mus musculus 105-108 22715193-1 2012 Adrenarche is an endocrine developmental process whereby humans and select nonhuman primates increase adrenal output of a series of steroids, especially DHEA and DHEAS. Steroids 132-140 sulfotransferase family 2A member 1 Homo sapiens 162-167 22703301-4 2012 Raloxifene, a synthetic steroid used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid precusor, are reported to be sulfated efficiently by SULT2A1 in vitro, yet unlike DHEA, raloxifene is not sulfated in vivo. Steroids 24-31 sulfotransferase family 2A member 1 Homo sapiens 181-188 22703301-4 2012 Raloxifene, a synthetic steroid used in the prevention of osteoporosis, and dehydroepiandrosterone (DHEA), a ubiquitous steroid precusor, are reported to be sulfated efficiently by SULT2A1 in vitro, yet unlike DHEA, raloxifene is not sulfated in vivo. Steroids 120-127 sulfotransferase family 2A member 1 Homo sapiens 181-188 22565185-1 2012 BACKGROUND: Mutations in the NPHS1 and NPHS2 genes are among the main causes of early-onset and familial steroid resistant nephrotic syndrome respectively. Steroids 105-112 NPHS1 adhesion molecule, nephrin Homo sapiens 29-34 21763750-6 2012 In the ovary, FOXL2 is involved in the regulation of cholesterol and steroid metabolism, apoptosis, reactive oxygen species detoxification and cell proliferation. Steroids 69-76 forkhead box L2 Homo sapiens 14-19 22340076-0 2012 Gonadal steroid induction of kisspeptin peptide expression in the rostral periventricular area of the third ventricle during postnatal development in the male mouse. Steroids 8-15 KiSS-1 metastasis-suppressor Mus musculus 29-39 22340076-4 2012 The present experiments investigated the potential role of gonadal steroids in the induction of kisspeptin expression in the RP3V during pubertal development in the male mouse. Steroids 67-75 KiSS-1 metastasis-suppressor Mus musculus 96-106 22340076-9 2012 These results indicate that, as in females, gonadal steroids are essential for the increase in kisspeptin immunoreactive cell number that occurs in the RP3V during pubertal development in the male mouse. Steroids 52-60 KiSS-1 metastasis-suppressor Mus musculus 95-105 22340198-1 2012 The KISS1/Kiss1/kiss1 gene product kisspeptin is suggested to be involved in the steroid feedback system in vertebrates. Steroids 81-88 KiSS-1 metastasis suppressor Homo sapiens 4-9 22340198-1 2012 The KISS1/Kiss1/kiss1 gene product kisspeptin is suggested to be involved in the steroid feedback system in vertebrates. Steroids 81-88 KiSS-1 metastasis suppressor Homo sapiens 10-15 22340198-1 2012 The KISS1/Kiss1/kiss1 gene product kisspeptin is suggested to be involved in the steroid feedback system in vertebrates. Steroids 81-88 KiSS-1 metastasis suppressor Homo sapiens 16-21 22340198-8 2012 Given that amphibians express kiss2 in POA and mammalian anteroventral periventricular nucleus/POA Kiss1 neurones show similar expression dynamics as goldfish POA Kiss2 neurones, we hypothesise that kiss1 and kiss2 share the same evolutionary origin; and, after the loss of kiss2, kiss1 became active for steroid feedback in mammals. Steroids 305-312 KiSS-1 metastasis suppressor Homo sapiens 199-204 22415563-1 2012 OBJECTIVE: The perimenopausal increase in circulating dehydroepiandrosterone sulfate (DHEAS) levels during the menopausal transition (MT) is accompanied by other adrenal steroids that have the potential to alter estrogen/androgen balance and explain the wide interwoman range of estrogen-related symptoms experienced during the MT. Steroids 170-178 sulfotransferase family 2A member 1 Homo sapiens 86-91 22415570-4 2012 This study was designed to test the hypothesis that the menopausal stage-specific change in circulating DHEAS is associated with concomitant changes in the circulating pattern of adrenal steroids and that some of these adrenal androgens could influence the circulating estrogen/androgen balance. Steroids 187-195 sulfotransferase family 2A member 1 Homo sapiens 104-109 22376279-4 2012 The KiSS-1/GPR54 system stimulates the gonadotrophin releasing hormone (GnRH) neurons and is involved in the feedback regulation of the HPG axis by gonadal steroids. Steroids 156-164 KiSS-1 metastasis suppressor Homo sapiens 4-10 22506561-0 2012 Novel steroid inhibitors of glucose 6-phosphate dehydrogenase. Steroids 6-13 glucose-6-phosphate dehydrogenase Homo sapiens 28-61 22506561-1 2012 Novel derivatives of the steroid DHEA 1, a known uncompetitive inhibitor of G6PD, were designed, synthesized, and tested for their ability to inhibit this dehydrogenase enzyme. Steroids 25-32 glucose-6-phosphate dehydrogenase Homo sapiens 76-80 22506561-3 2012 The SAR for steroid inhibition of G6PD has been substantially developed; the 3beta-alcohol can be replaced with 3beta-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate. Steroids 12-19 sarcosine dehydrogenase Homo sapiens 4-7 22506561-3 2012 The SAR for steroid inhibition of G6PD has been substantially developed; the 3beta-alcohol can be replaced with 3beta-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate. Steroids 12-19 glucose-6-phosphate dehydrogenase Homo sapiens 34-38 22298120-0 2012 Corticotropin-releasing factor modulation of forebrain GABAergic transmission has a pivotal role in the expression of anabolic steroid-induced anxiety in the female mouse. Steroids 127-134 corticotropin releasing hormone Mus musculus 0-30 22465009-9 2012 Thus, although steroids that bind GR with high affinity can induce GR and p300 occupancy of target promoters, they may not induce a conformation of GR capable of activating transcription. Steroids 15-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 34-36 22465009-9 2012 Thus, although steroids that bind GR with high affinity can induce GR and p300 occupancy of target promoters, they may not induce a conformation of GR capable of activating transcription. Steroids 15-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 67-69 22465009-9 2012 Thus, although steroids that bind GR with high affinity can induce GR and p300 occupancy of target promoters, they may not induce a conformation of GR capable of activating transcription. Steroids 15-23 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 67-69 22342158-1 2012 The nuclear receptor coactivator amplified in breast cancer 1 (AIB1/SRC-3) has a well-defined role in steroid and growth factor signaling in cancer and normal epithelial cells. Steroids 102-109 nuclear receptor coactivator 3 Mus musculus 68-73 22260839-9 2012 Potentiation occurs at nanomolar steroid levels and depends on GPR30 and EGFR transactivation. Steroids 33-40 G protein-coupled estrogen receptor 1 Homo sapiens 63-68 21962473-12 2012 CONCLUSION: Patients with an electrodiagnostically mild CTS (i.e., abnormal comparative tests or prolonged median DSL>3.5 ms but normal median DML) are good candidates for a local steroid injection with 50% having a good long term effect for more than 15 months. Steroids 183-190 transthyretin Homo sapiens 56-59 21962473-13 2012 SIGNIFICANCE: This study shows that the EMG severity of CTS is an important prognostic factor for the long term effect of a local steroid injection. Steroids 130-137 transthyretin Homo sapiens 56-59 22337907-9 2012 When expressed in Chinese hamster ovary cells, CBG A51V bound steroid normally, but its production/secretion was severely impaired; CBG E102G was produced normally, but its cortisol-binding capacity was abnormally low, whereas CBG R64Q and R64W were produced and bound cortisol normally. Steroids 62-69 corticosteroid-binding globulin Cricetulus griseus 47-50 22236481-9 2012 In conclusion, our studies show that adrenal-derived steroids protect against the development of initial atherosclerotic lesions in LDL receptor knockout mice. Steroids 53-61 low density lipoprotein receptor Mus musculus 132-144 21948316-0 2012 Sex steroid hormones regulate the expression of growth-associated protein 43, microtubule-associated protein 2, synapsin 1 and actin in the ventromedial nucleus of the hypothalamus. Steroids 4-20 synapsin I Rattus norvegicus 112-122 22410070-5 2012 We have herein described four successful cases of steroid withdrawal among adult patients who underwent living donor OLT from ABO-incompatible donors. Steroids 50-57 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 126-129 22101253-4 2012 More recently, the roles of these two human ferredoxins in iron-sulfur cluster assembly were assessed, and it was concluded that FDX1 was important solely for its interaction with p450 enzymes to synthesize mitochondrial steroid precursors, whereas FDX2 was used for synthesis of iron-sulfur clusters, but not steroidogenesis. Steroids 221-228 ferredoxin 1 Homo sapiens 129-133 22202164-1 2012 Kisspeptin, encoded by the Kiss1 gene, stimulates GnRH secretion and is therefore critical for sex steroid secretion at puberty and in adulthood. Steroids 99-106 KiSS-1 metastasis-suppressor Mus musculus 0-10 22202164-1 2012 Kisspeptin, encoded by the Kiss1 gene, stimulates GnRH secretion and is therefore critical for sex steroid secretion at puberty and in adulthood. Steroids 99-106 KiSS-1 metastasis-suppressor Mus musculus 27-32 22202164-2 2012 However, kisspeptin"s role in regulating sex steroid secretion earlier in development is unexplored. Steroids 45-52 KiSS-1 metastasis-suppressor Mus musculus 9-19 22182832-1 2012 Dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, are the most abundant steroids circulating in human blood. Steroids 83-91 sulfotransferase family 2A member 1 Homo sapiens 53-59 22201945-5 2012 During early pregnancy, temporally and spatially regulated patterns of AIF expression were found in the mouse uterus; AIF expression in the luminal epithelium and glandular epithelium is regulated by steroid hormones; AIF mRNA expression in the stroma is influenced by the active blastocyst; and AIF protein was found to be located in the cytoplasm rather than the nucleus through confocal microscope. Steroids 200-216 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 118-121 22201945-5 2012 During early pregnancy, temporally and spatially regulated patterns of AIF expression were found in the mouse uterus; AIF expression in the luminal epithelium and glandular epithelium is regulated by steroid hormones; AIF mRNA expression in the stroma is influenced by the active blastocyst; and AIF protein was found to be located in the cytoplasm rather than the nucleus through confocal microscope. Steroids 200-216 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 118-121 22201945-5 2012 During early pregnancy, temporally and spatially regulated patterns of AIF expression were found in the mouse uterus; AIF expression in the luminal epithelium and glandular epithelium is regulated by steroid hormones; AIF mRNA expression in the stroma is influenced by the active blastocyst; and AIF protein was found to be located in the cytoplasm rather than the nucleus through confocal microscope. Steroids 200-216 apoptosis-inducing factor, mitochondrion-associated 1 Mus musculus 118-121 21374593-2 2012 Recent in vitro studies have shown that dihydrotestosterone and anabolic steroids have functions in promoting the proliferation and differentiation of the mouse skeletal muscle myoblast C2C12 cell line through the classical androgen receptor (AR) signaling pathway. Steroids 73-81 androgen receptor Mus musculus 224-241 21374593-2 2012 Recent in vitro studies have shown that dihydrotestosterone and anabolic steroids have functions in promoting the proliferation and differentiation of the mouse skeletal muscle myoblast C2C12 cell line through the classical androgen receptor (AR) signaling pathway. Steroids 73-81 androgen receptor Mus musculus 243-245 21592236-6 2012 Neurones producing kisspeptin, the protein product of the Kiss1 gene, and RFRP-3 have been shown to provide excitatory and inhibitory input to GnRH neurones, respectively, and are also influenced by sex steroid and circadian signals. Steroids 203-210 KiSS-1 metastasis suppressor Homo sapiens 58-63 21951109-5 2012 The mechanisms of action of TSPO ligands involve the regulation of mitochondrial activity and the stimulation of steroid biosynthesis. Steroids 113-120 translocator protein Rattus norvegicus 28-32 22074953-5 2012 This role is fulfilled in Xenopus by CAR, which exhibits low basal activity and pronounced responsiveness to activators such as drugs and steroids, altogether resembling mammalian PXR. Steroids 138-146 nuclear receptor subfamily 1 group I member 3 Homo sapiens 37-40 22701646-0 2012 Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. Steroids 104-111 dicer 1, ribonuclease type III Mus musculus 0-6 22701646-8 2012 The dedifferentiated epithelium also showed an increase in estrogen receptor 1 expression while the expression of androgen receptor and its target genes; glutathione peroxidase 5, lipocalin 5 and cysteine-rich secretory protein 1 was downregulated, indicating imbalanced sex steroid signaling. Steroids 275-282 androgen receptor Mus musculus 114-131 21962440-9 2011 Finally, PDE mutations may lead to several human diseases characterized by abnormal steroid levels. Steroids 84-91 aldehyde dehydrogenase 7 family member A1 Homo sapiens 9-12 22014147-7 2011 17beta-Oestradiol, either alone or in combination with other steroids, up-regulated the PR gene and protein expression, even in the absence of detectable histological changes in the accessory sex glands, confirming the high sensitivity of PR gene expression as an indirect diagnostic screening tool to detect illicit oestrogen treatment in sexually mature male bovine. Steroids 61-69 progesterone receptor Bos taurus 88-90 21887718-9 2011 Moreover, steroid replacements, in vitro protease assays, and cell lysate fractionation showed that eIF4E cleavage and 4E-BP1 decay both depended on the ovarian steroid hormones estradiol and progestrone, but these effects are the result of different proteolytic activities. Steroids 10-17 eukaryotic translation initiation factor 4E Sus scrofa 100-105 21887718-9 2011 Moreover, steroid replacements, in vitro protease assays, and cell lysate fractionation showed that eIF4E cleavage and 4E-BP1 decay both depended on the ovarian steroid hormones estradiol and progestrone, but these effects are the result of different proteolytic activities. Steroids 161-177 eukaryotic translation initiation factor 4E Sus scrofa 100-105 21251916-0 2011 Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. Steroids 50-57 sigma non-opioid intracellular receptor 1 Rattus norvegicus 103-119 22014308-1 2011 BACKGROUND: The aldo-keto reductase family 1 member C1 (AKR1C1) belongs to a superfamily of NADPH-dependent reductases that convert a wide range of substrates, including carbohydrates, steroid hormones, and endogenous prostaglandins. Steroids 185-201 aldo-keto reductase family 1 member C1 Sus scrofa 16-54 22014308-1 2011 BACKGROUND: The aldo-keto reductase family 1 member C1 (AKR1C1) belongs to a superfamily of NADPH-dependent reductases that convert a wide range of substrates, including carbohydrates, steroid hormones, and endogenous prostaglandins. Steroids 185-201 aldo-keto reductase family 1 member C1 Sus scrofa 56-62 21949360-3 2011 Photoexcitation of a fluorescent analog (coumarin 183) of the reaction intermediate mimics the change in charge distribution that occurs between the reactant and intermediate state in the steroid substrate of KSI. Steroids 188-195 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 209-212 21701417-13 2011 Characterization of the novel hyperactive hGR NS-1 provides insight into a possible mechanism underlying the unpredictable response to steroid treatment. Steroids 135-142 influenza virus NS1A binding protein Homo sapiens 46-50 22018177-4 2011 Structurally the presence or lack of oxygenation at C11 on the steroid skeleton was critical. Steroids 63-70 RNA polymerase III subunit K Homo sapiens 52-55 21420458-11 2011 Hence, the properties acquired by hGDH2 during its evolution have made the enzyme a selective target for neuroactive steroids and drugs, providing new means for therapeutic interventions in disorders linked to deregulation of this enzyme. Steroids 117-125 glutamate dehydrogenase 2 Homo sapiens 34-39 21216259-4 2011 Kisspeptin and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion, the former being a major conduit for transmission of sex steroid feedback. Steroids 153-160 pro-FMRFamide-related neuropeptide VF Ovis aries 15-46 21216259-4 2011 Kisspeptin and gonadotropin inhibitory hormone (GnIH) neurons are regulators of GnRH secretion, the former being a major conduit for transmission of sex steroid feedback. Steroids 153-160 pro-FMRFamide-related neuropeptide VF Ovis aries 48-52 21421891-1 2011 OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a ubiquitous lipocalin that serves as a critical component of innate immunity and a transport shuttle for numerous substances (retinoids, arachidonic acid, prostaglandins, fatty acids, steroids, iron, and MMPs). Steroids 249-257 lipocalin 2 Homo sapiens 11-53 21421891-1 2011 OBJECTIVE: Neutrophil gelatinase-associated lipocalin (NGAL) is a ubiquitous lipocalin that serves as a critical component of innate immunity and a transport shuttle for numerous substances (retinoids, arachidonic acid, prostaglandins, fatty acids, steroids, iron, and MMPs). Steroids 249-257 lipocalin 2 Homo sapiens 55-59 21680247-0 2011 Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells. Steroids 66-73 follicle stimulating hormone receptor Homo sapiens 15-27 21674705-8 2011 Interleukin (IL)-10 was markedly increased at baseline in steroid-responsive patients compared to the nonresponders (P = 0.006; sensitivity: 88.8%; specificity: 66.6% to predict steroid response). Steroids 58-65 interleukin 10 Homo sapiens 0-19 21674705-8 2011 Interleukin (IL)-10 was markedly increased at baseline in steroid-responsive patients compared to the nonresponders (P = 0.006; sensitivity: 88.8%; specificity: 66.6% to predict steroid response). Steroids 178-185 interleukin 10 Homo sapiens 0-19 21674705-10 2011 In contrast, increased expression of IL-10 at an early stage of active steroid-sensitive CD patients supports its usefulness at predicting a good steroid response. Steroids 71-78 interleukin 10 Homo sapiens 37-42 21674705-10 2011 In contrast, increased expression of IL-10 at an early stage of active steroid-sensitive CD patients supports its usefulness at predicting a good steroid response. Steroids 146-153 interleukin 10 Homo sapiens 37-42 21674517-2 2011 The purpose of this study was to use neuromuscular ultrasound to assess the changes that occur in the median nerve after steroid injection for carpal tunnel syndrome (CTS). Steroids 121-128 transthyretin Homo sapiens 167-170 21645256-9 2011 The use of steroids and monoclonal antibodies reduced IL-17 expression, JAK2 phosphorylation and C4d deposition in acute ABMR patients. Steroids 11-19 interleukin 17A Homo sapiens 54-59 22506149-1 2011 OBJECTIVE: To verify the feasibility of initial parameters of ultrasonography or electromyography for the prediction of effect after steroid injection therapy in a carpal tunnel syndrome (CTS) patient. Steroids 133-140 transthyretin Homo sapiens 188-191 21363930-10 2011 Thus, in rodents, Kiss1 is expressed and regulated by sex steroids in the MeA of both sexes and may play a role in modulating reproduction or brain functions that extend beyond reproduction. Steroids 58-66 KiSS-1 metastasis-suppressor Rattus norvegicus 18-23 21167252-6 2011 This effect could be partially explained by reduced expression of enzymes involved in the synthesis of latter steroids--CYP11B1 and CYP11B2. Steroids 110-118 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 120-127 21185333-0 2011 Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids. Steroids 85-93 glucose-6-phosphate dehydrogenase Homo sapiens 0-33 21185333-1 2011 Steroids such as dehydroepiandrosterone (DHEA) and epiandrosterone (EA) exert multiple effects in mammals including the inhibition of glucose-6-phosphate dehydrogenase (G6PDH). Steroids 0-8 glucose-6-phosphate dehydrogenase Homo sapiens 134-167 21185333-1 2011 Steroids such as dehydroepiandrosterone (DHEA) and epiandrosterone (EA) exert multiple effects in mammals including the inhibition of glucose-6-phosphate dehydrogenase (G6PDH). Steroids 0-8 glucose-6-phosphate dehydrogenase Homo sapiens 169-174 21483824-1 2011 BACKGROUND: The 1alpha,25-dihydroxy-3-epi-vitamin-D3 (1alpha,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription regulator. Steroids 113-120 vitamin D receptor Homo sapiens 195-221 21483824-1 2011 BACKGROUND: The 1alpha,25-dihydroxy-3-epi-vitamin-D3 (1alpha,25(OH)2-3-epi-D3), a natural metabolite of the seco-steroid vitamin D3, exerts its biological activity through binding to its cognate vitamin D nuclear receptor (VDR), a ligand dependent transcription regulator. Steroids 113-120 vitamin D receptor Homo sapiens 223-226 21172301-8 2011 The catalytic activity in steroid isomerization reactions was at least 10-fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene was approximately 8-fold higher. Steroids 26-33 glutathione S-transferase alpha 2 Homo sapiens 127-135 21215267-6 2011 Interestingly, we found that ecdysone, the steroid hormone responsible for the larval lethal phenotype in npc1 mutants, is not required for individualization. Steroids 43-58 Niemann-Pick type C-1a Drosophila melanogaster 106-110 21088224-3 2011 The UGT1 and UGT2 family members primarily use UDP glucuronic acid to glucuronidate numerous compounds, such as steroids, bile acids, and therapeutic drugs. Steroids 112-120 UDP-glucose glycoprotein glucosyltransferase 2 Homo sapiens 13-17 21337702-4 2011 Using narrow range 2-DE gels and MALDI-TOF-MS analysis, we identified three sex steroid-regulated proteins: the galectin-related-inter-fiber (GRIFIN) which is a galectin family member protein of unknown function, the fatty acid-binding protein epidermal-5 (FABP5) protein responsible for the fatty acid uptake and transport and the small heat shock alphaA-crystallin (CRYAA) protein involved in preventing aggregation of denatured or unfolded proteins. Steroids 80-87 galectin-related inter-fiber protein Rattus norvegicus 142-148 21047519-7 2011 SIGNIFICANCE: DPP4 is crucial for regulating the expression of factors related to steroid metabolism such as Cyp51, Sc4mol, and Hsd17b2, and DPP4 deficiency or inhibition may cause dyslipidemia. Steroids 82-89 cytochrome P450, family 51 Rattus norvegicus 109-114 20348971-0 2011 Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective. Steroids 11-18 CD52 molecule Homo sapiens 46-50 21394787-3 2011 RESULTS: While we found plasma cortisol concentrations to be unchanged, a decline in plasma DHEA-S concentrations indicated effective steroid-synthesis inhibition. Steroids 134-141 sulfotransferase family 2A member 1 Homo sapiens 92-98 22205965-4 2011 TSPO is a drug- and cholesterol-binding protein involved in mitochondrial respiration, steroid formation, and cell proliferation. Steroids 87-94 translocator protein Homo sapiens 0-4 20851775-0 2010 The neuro-steroid, 5-androstene 3beta,17alpha diol; induces endoplasmic reticulum stress and autophagy through PERK/eIF2alpha signaling in malignant glioma cells and transformed fibroblasts. Steroids 10-17 eukaryotic translation initiation factor 2A Homo sapiens 116-125 20851775-6 2010 Neuro-steroid treatment caused the activation of the eIF2alpha kinase, protein kinase-like ER kinase (PERK) but not other eIF2alpha kinases in glioma cells. Steroids 6-13 eukaryotic translation initiation factor 2A Homo sapiens 53-62 20851775-6 2010 Neuro-steroid treatment caused the activation of the eIF2alpha kinase, protein kinase-like ER kinase (PERK) but not other eIF2alpha kinases in glioma cells. Steroids 6-13 eukaryotic translation initiation factor 2A Homo sapiens 122-131 20851775-8 2010 T98G cells transfected with a dominant-negative PERK construct exhibited an attenuated response to neuro-steroid treatment in terms of decreases in: eIF2alpha activation; CHOP expression; the incidence of autophagy; and cytotoxicity. Steroids 105-112 eukaryotic translation initiation factor 2A Homo sapiens 149-158 20739385-1 2010 CONTEXT: Dehydroepiandrosterone sulfate (DHEA-S), a major circulating sex steroid prohormone, declines with age. Steroids 74-81 sulfotransferase family 2A member 1 Homo sapiens 41-47 20675569-8 2010 A significant suppression of CYP2C19 transcription by female sex steroids was confirmed by reverse transcription polymerase chain reaction after hormonal treatment of human hepatocytes. Steroids 65-73 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 29-36 20943927-1 2010 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) regenerates active glucocorticoids (GCs) from intrinsically inert 11-keto substrates inside cells, including neurons, thus amplifying steroid action. Steroids 14-21 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 44-55 20600583-2 2010 Although TSPO is found in many tissue types, it is expressed at the highest levels under normal conditions in tissues that synthesize steroids. Steroids 134-142 translocator protein Homo sapiens 9-13 21036711-1 2010 BACKGROUND: Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic molecule restricted to endocrine glands and, particularly, to steroid-secreting cells. Steroids 160-167 prokineticin 1 Homo sapiens 12-70 21036711-1 2010 BACKGROUND: Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is an angiogenic molecule restricted to endocrine glands and, particularly, to steroid-secreting cells. Steroids 160-167 prokineticin 1 Homo sapiens 72-79 20637751-18 2010 All of the above results suggested that the GR-mediated reduction of Na(+), K(+)-ATPase may contribute to the formation of steroid-induced cataract. Steroids 123-130 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 44-46 20817868-0 2010 IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Steroids 39-46 interleukin 27 Mus musculus 0-5 20817868-0 2010 IL-27/IFN-gamma induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages. Steroids 39-46 myeloid differentiation primary response gene 88 Mus musculus 23-28 20508064-11 2010 The cyclic variations of GPER mRNA obviously relate to strong epithelial expression in the proliferative phase, and the expression pattern suggests regulation by ovarian steroids. Steroids 170-178 G protein-coupled estrogen receptor 1 Homo sapiens 25-29 20833730-3 2010 IFNgamma and TNFalpha synergistically induce CXCL10 release from human ASM cells in a steroid-insensitive manner, via an as yet undefined mechanism. Steroids 86-93 C-X-C motif chemokine ligand 10 Homo sapiens 45-51 20621066-5 2010 Beyond its expression in steroid-producing tissues, heart, liver and kidney, the PBR is also known to be highly expressed in blood cells. Steroids 25-32 translocator protein Homo sapiens 81-84 20103546-3 2010 The kallikrein locus is also notable because it is extraordinarily responsive to steroids and other hormones. Steroids 81-89 kallikrein related peptidase 4 Homo sapiens 4-14 20430028-8 2010 AR blockade, however, seemed to induce a preference for male odors rather than reduce the existing preference for estrous odors, suggesting a complicated regulation of sexual odor preference by sex steroids. Steroids 198-206 androgen receptor Rattus norvegicus 0-2 20059722-4 2010 RESULTS: Urinary NGAL level was significantly increased compared with the control in all of these disease groups except in patients with a remission stage of steroid-sensitive nephrotic syndrome, although a significant increase in serum NGAL level was observed in the renal dysfunction group only. Steroids 158-165 lipocalin 2 Homo sapiens 17-21 20395535-1 2010 Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. Steroids 160-168 ATP binding cassette subfamily C member 4 Homo sapiens 0-30 20395535-1 2010 Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. Steroids 160-168 ATP binding cassette subfamily C member 4 Homo sapiens 32-36 20395535-1 2010 Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. Steroids 160-168 ATP binding cassette subfamily C member 4 Homo sapiens 38-43 20659406-7 2010 A significant decrease was evident in the number of CCR3 expressing Monocytes among RA patients treated with steroids and anti TNF-a medications as compared with RA patients not receiving such treatment. Steroids 109-117 C-C motif chemokine receptor 3 Homo sapiens 52-56 20338923-3 2010 In this study, we examine a distinct mechanism by which cyclin D1 regulates sex steroid signaling, via altered metabolism of these hormones at the tissue and cellular level. Steroids 80-87 cyclin D1 Mus musculus 56-65 20338923-4 2010 In male mouse liver, ectopic expression of cyclin D1 regulated genes involved in the synthesis and degradation of sex steroid hormones in a pattern that would predict increased estrogen and decreased androgen levels. Steroids 118-134 cyclin D1 Mus musculus 43-52 20420909-2 2010 The goals of this project are to determine if Arg195 in 3beta-HSD1 vs. Pro195 in 3beta-HSD2 in the substrate/inhibitor binding site is a critical structural difference responsible for the higher affinity of 3beta-HSD1 for inhibitor and substrate steroids compared to 3beta-HSD2 and whether Asp61, Glu192 and Thr8 are fingerprint residues for cofactor and substrate binding using site-directed mutagenesis. Steroids 246-254 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 56-66 20420909-2 2010 The goals of this project are to determine if Arg195 in 3beta-HSD1 vs. Pro195 in 3beta-HSD2 in the substrate/inhibitor binding site is a critical structural difference responsible for the higher affinity of 3beta-HSD1 for inhibitor and substrate steroids compared to 3beta-HSD2 and whether Asp61, Glu192 and Thr8 are fingerprint residues for cofactor and substrate binding using site-directed mutagenesis. Steroids 246-254 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 207-217 21540998-0 2010 Functional interactions between steroid hormones and neurotrophin BDNF. Steroids 32-48 brain derived neurotrophic factor Homo sapiens 66-70 21540998-8 2010 Here, we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones (glucocorticoids and estrogen). Steroids 123-139 brain derived neurotrophic factor Homo sapiens 94-98 20463213-0 2010 Altered GABAA receptor-mediated synaptic transmission disrupts the firing of gonadotropin-releasing hormone neurons in male mice under conditions that mimic steroid abuse. Steroids 157-164 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 8-13 20463213-8 2010 Our results indicate that AAS act predominantly on steroid-sensitive presynaptic neurons within the mPOA to impart significant increases in GABAA receptor-mediated inhibitory tone onto downstream GnRH neurons, resulting in diminished activity of these pivotal mediators of reproductive function. Steroids 51-58 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 140-145 20459697-3 2010 Based on animal in vivo observations we hypothesised that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 (RANTES), a CC-chemokine regulating eosinophil and lymphocyte traffic, and elimination of eosinophils without evident occurrence of apoptotic eosinophils in the diseased tissue. Steroids 58-65 C-C motif chemokine ligand 5 Homo sapiens 150-154 20459697-3 2010 Based on animal in vivo observations we hypothesised that steroid-induced resolution of human airway eosinophilic inflammation involves inhibition of CCL5 (RANTES), a CC-chemokine regulating eosinophil and lymphocyte traffic, and elimination of eosinophils without evident occurrence of apoptotic eosinophils in the diseased tissue. Steroids 58-65 C-C motif chemokine ligand 5 Homo sapiens 156-162 20459697-10 2010 Steroid treatment also attenuated tissue expression of CCL5, but CCL11 was not reduced. Steroids 0-7 C-C motif chemokine ligand 5 Homo sapiens 55-59 20459697-13 2010 CONCLUSIONS: Inhibition of CCL5-dependent recruitment of cells to diseased airway tissue, and reduced cell proliferation, reduced general cell apoptosis, but not increased eosinophil apoptosis, are involved in early phase steroid-induced resolution of human allergic rhinitis. Steroids 222-229 C-C motif chemokine ligand 5 Homo sapiens 27-31 20819443-0 2010 Changes in femoral head blood supply and vascular endothelial growth factor in rabbits with steroid-induced osteonecrosis. Steroids 92-99 vascular endothelial growth factor A Oryctolagus cuniculus 41-75 20819443-2 2010 The aim of this study was to investigate changes in the femoral head blood supply and vascular endothelial growth factor (VEGF) protein levels following steroid-induced ON of rabbit femoral heads in the early stage of the disease, and to investigate a possible mechanism for ON. Steroids 153-160 vascular endothelial growth factor A Oryctolagus cuniculus 86-120 20819443-2 2010 The aim of this study was to investigate changes in the femoral head blood supply and vascular endothelial growth factor (VEGF) protein levels following steroid-induced ON of rabbit femoral heads in the early stage of the disease, and to investigate a possible mechanism for ON. Steroids 153-160 vascular endothelial growth factor A Oryctolagus cuniculus 122-126 20072790-1 2010 The aim of work was to investigate whether serum and urinary neutrophil gelatinase-associated lipocalin(sNGAL and uNGAL, respectively) are potential biomarkers of early cyclosporine A (CsA) nephrotoxicity in steroid-dependent nephrotic children (SDNS). Steroids 208-215 lipocalin 2 Homo sapiens 61-103 20348459-4 2010 Because both the duration of the nocturnal peak of melatonin and circulating sex steroid levels vary with photoperiod, the aim of this study was to determine whether melatonin and sex steroids differentially regulate Kiss1 expression in the ARC and the AVPV. Steroids 184-192 metastasis-suppressor KiSS-1 Mesocricetus auratus 217-222 20010328-0 2010 Late steroid withdrawal after ABO blood group-incompatible living donor kidney transplantation: high rate of mild cellular rejection. Steroids 5-12 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 30-33 20010328-1 2010 BACKGROUND: Little is known about the safety of steroid withdrawal after ABO blood group-incompatible living donor kidney transplantation. Steroids 48-55 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 73-76 20010328-7 2010 CONCLUSIONS: With this elevated risk of at least subclinical acute rejection after late steroid withdrawal, we propose that steroid withdrawal in ABO blood group-incompatible kidney graft recipients should only be performed after a protocol biopsy showing normal tissue and together with a thorough clinical and in doubtful cases also histologic follow-up. Steroids 124-131 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 146-149 20025869-5 2010 In addition, we demonstrate that scratch-induced upregulation of rip2 expression is completely blocked by the steroid dexamethasone. Steroids 110-117 receptor interacting serine/threonine kinase 2 Homo sapiens 65-69 20036234-0 2010 Involvement of 1,25D3-MARRS (membrane associated, rapid response steroid-binding), a novel vitamin D receptor, in growth inhibition of breast cancer cells. Steroids 65-72 vitamin D receptor Homo sapiens 91-109 20036234-2 2010 Although cellular effects of 1,25(OH)2D3 traditionally have been attributed to activation of a nuclear vitamin D receptor (VDR), a novel receptor for 1,25(OH)2D3 called 1,25D3-MARRS (membrane-associated, rapid response steroid-binding) protein was identified recently. Steroids 219-226 vitamin D receptor Homo sapiens 103-121 20036234-2 2010 Although cellular effects of 1,25(OH)2D3 traditionally have been attributed to activation of a nuclear vitamin D receptor (VDR), a novel receptor for 1,25(OH)2D3 called 1,25D3-MARRS (membrane-associated, rapid response steroid-binding) protein was identified recently. Steroids 219-226 vitamin D receptor Homo sapiens 123-126 19922790-1 2010 The molecular mechanisms that underlie non-genomic induction of the 25-hydroxyvitamin D3 24-hydroxylase (CYP24) gene promoter by the steroid hormone, 1,25-Dihydroxyvitamin D3 (1,25D), are poorly understood. Steroids 133-148 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 105-110 20085912-4 2010 METHODS: The gene expression of BMP7 in endometrial tissues collected from women with regular menstrual cycles was determined and the effect of ovarian steroid hormones on BMP7 gene expression was investigated in cultured ESC. Steroids 152-168 bone morphogenetic protein 7 Homo sapiens 172-176 20124949-0 2010 Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response. Steroids 98-105 arginase 2 Homo sapiens 15-25 20386663-10 2010 Steroid hormones, progesterone stimulated miR-320 expression. Steroids 0-16 microRNA 320a Rattus norvegicus 42-49 19804449-9 2010 RESULTS: Inhaled steroid medication increased BAL levels of MMP-9 and MMP-9/TIMP-1 and decreased MMP-7 and MMP-7/TIMP-1. Steroids 17-24 matrix metallopeptidase 9 Homo sapiens 60-65 19804449-9 2010 RESULTS: Inhaled steroid medication increased BAL levels of MMP-9 and MMP-9/TIMP-1 and decreased MMP-7 and MMP-7/TIMP-1. Steroids 17-24 matrix metallopeptidase 9 Homo sapiens 70-75 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 X-ray repair cross complementing 1 Homo sapiens 30-35 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 X-ray repair cross complementing 3 Homo sapiens 44-49 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 ANIB1 Homo sapiens 126-130 19360465-3 2010 Of the analyzed genes, ERCC2, XRCC1, XRCC2, XRCC3 and Lig4 participate in DNA repair, TP53 in cell cycle check point control, AIB1, AR, COMT, CYP11A1, CYP17A1, CYP19A1, HSD17 and PGR in steroid hormone biosynthesis/metabolism/signaling, TYMS in folate metabolism and HER2, IL6, LRP1, TGFB and TGFBR1 affect cell growth. Steroids 186-201 hydroxysteroid 17-beta dehydrogenase 1 pseudogene 1 Homo sapiens 169-174 21299064-8 2010 In females, levels of endogenous GAL also fluctuate across the reproductive cycle, driven by a rise in the ovarian steroids, estrogen, and progesterone. Steroids 115-123 galanin and GMAP prepropeptide Homo sapiens 33-36 20389082-3 2010 In addition, the KISS1 gene is a target for regulation by gonadal steroids in both sexes. Steroids 66-74 KiSS-1 metastasis suppressor Homo sapiens 17-22 19912479-1 2010 Recent evidence has implicated neurokinin B (NKB) in the complex neuronal network mediating the effects of gonadal steroids on the regulation of gonadotrophin-releasing hormone (GnRH) secretion. Steroids 115-123 tachykinin-3 Ovis aries 31-43 19912479-1 2010 Recent evidence has implicated neurokinin B (NKB) in the complex neuronal network mediating the effects of gonadal steroids on the regulation of gonadotrophin-releasing hormone (GnRH) secretion. Steroids 115-123 tachykinin-3 Ovis aries 45-48 19942152-3 2009 Gonadal steroids exert their influence on thyroid function primarily by altering the clearance of thyroxine-binding globulin (TBG). Steroids 8-16 serpin family A member 7 Homo sapiens 98-124 19942152-3 2009 Gonadal steroids exert their influence on thyroid function primarily by altering the clearance of thyroxine-binding globulin (TBG). Steroids 8-16 serpin family A member 7 Homo sapiens 126-129 19942152-5 2009 These effects of gonadal steroids on TBG clearance and concentration are modulated by the chemical structure of the steroid being used, its dose and the route of administration. Steroids 25-33 serpin family A member 7 Homo sapiens 37-40 19942152-5 2009 These effects of gonadal steroids on TBG clearance and concentration are modulated by the chemical structure of the steroid being used, its dose and the route of administration. Steroids 25-32 serpin family A member 7 Homo sapiens 37-40 19942152-6 2009 Despite the gonadal steroids-induced changes in serum TBG concentrations, subjects with normal thyroid glands maintain clinical and biochemical euthyroidism without changes in their serum free thyroxine (T4) or thyroid-stimulating hormone (TSH) levels. Steroids 20-28 serpin family A member 7 Homo sapiens 54-57 19854864-1 2009 We identified a novel synthetic steroid, S42, as a promising candidate of selective androgen receptor (AR) modulator. Steroids 32-39 androgen receptor Rattus norvegicus 84-101 19854864-1 2009 We identified a novel synthetic steroid, S42, as a promising candidate of selective androgen receptor (AR) modulator. Steroids 32-39 androgen receptor Rattus norvegicus 103-105 19922474-3 2009 Our studies have demonstrated that HOXC13 is transcriptionally activated by the steroid hormone estrogen (17beta-estradiol; E2). Steroids 80-95 homeobox C13 Homo sapiens 35-41 19763626-9 2009 Steroid-induced alterations of dental pain and inflammation coincide with altered exocytic capability in dental nerve fibers as shown by synaptophysin-IR and with altered pulp cell Na(v)1.6-IR and osteoclast number, but not with any changes in Na(v)1.6-IR for nodes of Ranvier in myelinated dental axons. Steroids 0-7 synaptophysin Rattus norvegicus 137-150 19625307-8 2009 These genes are involved principally in steroid metabolism and in the ovulation process and include TNFAIP6, a gene expressed during CC-oocyte complex (COC) expansion. Steroids 40-47 TNF alpha induced protein 6 Homo sapiens 100-107 19389484-9 2009 Collectively, our results demonstrate that basal and cAMP-induced Rbp4 transcription is regulated by a multiprotein complex that is similar to ones that modulate expression of genes of steroid hormone biosynthesis. Steroids 185-200 retinol binding protein 4, plasma Mus musculus 66-70 19826053-7 2009 Focusing on cholesterol ester as a source of de novo steroid synthesis, we show that ELOVL7 affected de novo androgen synthesis in prostate cancer cells. Steroids 53-60 ELOVL fatty acid elongase 7 Homo sapiens 85-91 19789311-2 2009 TSPO gene expression is high in tissues involved in steroid biosynthesis, neurodegenerative disease, and in cancer, and overexpression has been shown to contribute to pathologic conditions including cancer progression in several different models. Steroids 52-59 translocator protein Homo sapiens 0-4 19713307-1 2009 Podocin is a critical component of the glomerular slit diaphragm, and genetic mutations lead to both familial and sporadic forms of steroid-resistant nephrotic syndrome. Steroids 132-139 nephrosis 2, podocin Mus musculus 0-7 19297020-0 2009 Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia. Steroids 0-7 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 19-25 19297020-0 2009 Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia. Steroids 0-7 spleen associated tyrosine kinase Homo sapiens 30-33 19297020-8 2009 Therefore, the downregulation of ZAP-70 and P-SYK per se during treatment with GCs is not sufficient to induce apoptosis, and different mechanisms must therefore be responsible for the increased steroid sensitivity of ZAP-70+ CLL. Steroids 195-202 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 218-224 19595767-8 2009 These effects may represent a novel model of how reelin deficiency interacts with variable perinatal levels of neuroactive steroids, leading to gender-dependent differences in genetic vulnerability. Steroids 123-131 reelin Mus musculus 49-55 19419512-3 2009 METHODS: Comparison was done of the mRNA level of POH1 on real-time quantitative polymerase chain reaction in peripheral blood mononuclear cells among children with multidrug-resistant INS, children with steroid-sensitive INS and healthy controls. Steroids 204-211 proteasome 26S subunit, non-ATPase 14 Homo sapiens 50-54 19409385-7 2009 TSPO drug ligands have been shown to participate in the control of mitochondrial respiration and function, mitochondrial steroid and neurosteroid formation, as well as apoptosis. Steroids 121-128 translocator protein Homo sapiens 0-4 19662162-6 2009 UBP1 plays a role in cholesterol and steroid metabolism via the transcriptional activation of CYP11A, the rate-limiting enzyme in pregnenolone and aldosterone biosynthesis. Steroids 37-44 upstream binding protein 1 Homo sapiens 0-4 19392661-1 2009 BACKGROUND INFORMATION: The TSPO (18 kDa translocator protein) is a mitochondrial transmembrane protein involved in cholesterol transport in organs that synthesize steroids and bile salts. Steroids 164-172 translocator protein Rattus norvegicus 28-32 19286473-7 2009 The TSPO-dependent import of StAR into mitochondria, and the association of TSPO with the outer/inner mitochondrial membrane contact sites, drives the intramitochondrial cholesterol transfer and subsequent steroid formation. Steroids 206-213 translocator protein Homo sapiens 4-8 19286473-7 2009 The TSPO-dependent import of StAR into mitochondria, and the association of TSPO with the outer/inner mitochondrial membrane contact sites, drives the intramitochondrial cholesterol transfer and subsequent steroid formation. Steroids 206-213 translocator protein Homo sapiens 76-80 19702536-5 2009 Several drug-activated nuclear receptors including CAR, PXR, VDR, and GR recognize drug responsive elements within the 5" flanking promoter region of CYP2C genes to mediate the transcriptional upregulation of these genes in response to xenobiotics and steroids. Steroids 252-260 vitamin D receptor Homo sapiens 61-64 19702536-5 2009 Several drug-activated nuclear receptors including CAR, PXR, VDR, and GR recognize drug responsive elements within the 5" flanking promoter region of CYP2C genes to mediate the transcriptional upregulation of these genes in response to xenobiotics and steroids. Steroids 252-260 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 150-155 19490994-2 2009 Several recent studies suggest that 11 beta-HSD2 expression is subjected to regulation by antenatal steroid therapy. Steroids 100-107 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 36-48 19490994-3 2009 In our study we investigated the effect of two commonly used synthetic steroids, dexamethasone (DXM) and betamethasone (BTM), on the expression and function of 11 beta-HSD2 in the rat placenta. Steroids 71-79 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 160-172 19598235-8 2009 In the sex steroid group, this included ESR2 and CYP11B1. Steroids 11-18 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 49-56 20871735-1 2009 The constitutive androstane receptor (CAR) and the pregnane x receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupational chemicals. Steroids 149-165 nuclear receptor subfamily 1 group I member 3 Homo sapiens 4-36 20871735-1 2009 The constitutive androstane receptor (CAR) and the pregnane x receptor (PXR) are activated by a variety of endogenous and exogenous ligands, such as steroid hormones, bile acids, pharmaceuticals, and environmental, dietary, and occupational chemicals. Steroids 149-165 nuclear receptor subfamily 1 group I member 3 Homo sapiens 38-41 19158123-12 2009 CONCLUSIONS: Oral steroids promote epithelial repair in NP via upregulation of the AP-1 (especially c-Jun) network and its related genes. Steroids 18-26 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 100-105 19321788-7 2009 This analog also inhibited the kisspeptin-induced release of luteinizing hormone (LH) in rats and mice and blocked the postcastration rise in LH in sheep, rats, and mice, suggesting that kisspeptin neurons mediate the negative feedback effect of sex steroids on gonadotropin secretion in mammals. Steroids 250-258 KiSS-1 metastasis-suppressor Mus musculus 187-197 18983989-3 2009 By performing spectrophotometric analyses, we indicated that the enzymes CHCR1, CHCR2, and CHCR3 had similar specificities toward steroids; only CHCR3 did not show any reactivity with prostaglandins (PGs). Steroids 130-138 carbonyl reductase [NADPH] 3 Cricetulus griseus 91-96 19088159-0 2009 Aromatase and 5alpha-reductase inhibition during an exogenous testosterone clamp unveils selective sex steroid modulation of somatostatin and growth hormone secretagogue actions in healthy older men. Steroids 103-110 somatostatin Homo sapiens 125-137 19073137-2 2009 MRP4 also mediates the efflux of certain cyclic nucleotides, eicosanoids, conjugated steroids, and uric acid. Steroids 85-93 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 19063890-5 2009 Acting in a similar manner, gonadal steroids (estradiol and testosterone) stimulated both fshb and lhb, but had no effect on gh. Steroids 36-44 follicle stimulating hormone subunit beta Danio rerio 90-94 19818218-4 2009 VDR is a member of the steroid, estrogen and retinoid receptor gene family of proteins that mediate transcriptional activities of the respective ligands. Steroids 23-30 vitamin D receptor Homo sapiens 0-3 18923000-2 2009 These steroid hormones mediate their actions by binding to the androgen receptor (AR). Steroids 6-22 androgen receptor Mus musculus 63-80 20720595-4 2009 They help in follicular maturation, steroid secretion and ovulation in the ovary, by inducing the FSH receptor (FSHR). Steroids 36-43 follicle stimulating hormone receptor Homo sapiens 98-110 20720595-4 2009 They help in follicular maturation, steroid secretion and ovulation in the ovary, by inducing the FSH receptor (FSHR). Steroids 36-43 follicle stimulating hormone receptor Homo sapiens 112-116 19521113-2 2009 The successful adaptation to stress involves negative feedback at the level of the hypothalamic-pituitary-adrenal (HPA) axis provided by the glucocorticoid receptor (GR), which is a steroid-dependent transcription factor found in a heterocomplex with heat shock proteins Hsp90 and Hsp70. Steroids 182-189 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 141-164 19521113-2 2009 The successful adaptation to stress involves negative feedback at the level of the hypothalamic-pituitary-adrenal (HPA) axis provided by the glucocorticoid receptor (GR), which is a steroid-dependent transcription factor found in a heterocomplex with heat shock proteins Hsp90 and Hsp70. Steroids 182-189 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 166-168 18789989-3 2009 Kisspeptin producing cells in the hypothalamus are poised to become the "missing link" in the sex steroid feedback control of GnRH secretion. Steroids 98-105 metastasis-suppressor KiSS-1 Ovis aries 0-10 18789989-5 2009 Sex steroids regulate Kiss1 mRNA, and kisspeptin expression in the hypothalamus, in a manner consistent with both negative and positive feedback control of GnRH. Steroids 4-12 metastasis-suppressor KiSS-1 Ovis aries 22-27 18789989-6 2009 The precise nature of sex steroid effects, in particular those of estrogen, on Kiss1 expression have been extensively studied in the female rodent and ewe. Steroids 26-33 metastasis-suppressor KiSS-1 Ovis aries 79-84 18817822-6 2009 As in mammals, the fish KiSS1/GPR54 system appears to be partially regulated by gonadal steroids. Steroids 88-96 KiSS-1 metastasis suppressor Homo sapiens 24-29 19063989-14 2009 For example, clinically, the evidence that about 40% of NA-AION eyes experience spontaneous improvement in visual acuity and that systemic steroid therapy during early stages in both NA-AION and NA-PION has a significant beneficial effect for visual outcome are encouraging developments. Steroids 139-146 gamma-secretase activating protein Homo sapiens 198-202 18975922-1 2008 Translocator protein (TSPO) is an 18-kDa cholesterol-binding protein that is expressed at high levels in steroid synthesizing and several cancer cells where it is involved in steroidogenesis and cell proliferation, respectively. Steroids 105-112 transcription elongation factor B (SIII), polypeptide 2 (elongin B),-like Mus musculus 34-40 19189646-4 2008 This steroid has been shown to bind to the farnesoid X receptor and modulate expression of proteins with antiapoptotic (IAP1, XIAP, Bfl-1/A1, Bcl-2, cFLIP, survivin), cell survival, cell proliferation (cyclin D1, c-Myc), angiogenic, and metastatic (MMP-9, COX-2, VEGF) activities in tumor cells. Steroids 5-12 vascular endothelial growth factor A Bos taurus 263-267 18395250-3 2008 The role of steroid hormone 17beta-estradiol (E(2)), in [Ca(2+)](i) regulation involving TRPV6 has been only limited at the protein expression levels in over-expressing heterologous systems. Steroids 12-27 transient receptor potential cation channel subfamily V member 6 Homo sapiens 89-94 19210880-4 2008 After steroid therapy, both anti-hHSP60 and -C. pneumoniae antibodies decreased significantly in both groups of patients. Steroids 6-13 heat shock protein family D (Hsp60) member 1 Homo sapiens 33-39 18819819-0 2008 IL-18 is correlated with type-2 immune response in children with steroid sensitive nephrotic syndrome. Steroids 65-72 interleukin 18 Homo sapiens 0-5 18414429-3 2008 We have previously demonstrated that T-bet, a key transcription factor directing T helper type 1 inflammatory responses, is regulated by female steroid hormones in human mucosal epithelial cells via Stat1 and 5 pathways. Steroids 144-160 signal transducer and activator of transcription 1 Homo sapiens 199-210 18727654-2 2008 In this study, we examined the association between levels of the stress-related steroid hormones cortisol and dehydroepiandrosterone-sulphate (DHEAS) and periodontitis in elderly subjects. Steroids 80-96 sulfotransferase family 2A member 1 Homo sapiens 143-148 18642328-5 2008 PAK6 expression in LNCaP PCa cells was not directly androgen regulated, but was markedly increased when the cells were cultured for 6-8 weeks in steroid hormone depleted medium. Steroids 145-160 p21 (RAC1) activated kinase 6 Homo sapiens 0-4 18601981-2 2008 In the rat, these effects may be mediated through nongenomic steroid signaling such as estradiol activation of the Akt and LIM kinase (LIMK) pathways, in addition to genomic signaling involving estradiol upregulation of brain-derived neurotrophic factor expression (BDNF). Steroids 61-68 LIM-domain containing, protein kinase Mus musculus 123-133 18601981-2 2008 In the rat, these effects may be mediated through nongenomic steroid signaling such as estradiol activation of the Akt and LIM kinase (LIMK) pathways, in addition to genomic signaling involving estradiol upregulation of brain-derived neurotrophic factor expression (BDNF). Steroids 61-68 LIM-domain containing, protein kinase Mus musculus 135-139 18844613-0 2008 Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Steroids 23-31 C-C motif chemokine ligand 26 Homo sapiens 73-82 18844613-0 2008 Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Steroids 23-31 C-C motif chemokine ligand 26 Homo sapiens 83-88 18844613-1 2008 OBJECTIVES: Our aim was to evaluate the changes induced by topical steroid treatment to the esophageal epithelial inflammatory eosinophilic and T-cell infiltrate and to IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 esophageal gene expression levels in patients with eosinophilic esophagitis (EE). Steroids 67-74 C-C motif chemokine ligand 26 Homo sapiens 196-205 18844613-1 2008 OBJECTIVES: Our aim was to evaluate the changes induced by topical steroid treatment to the esophageal epithelial inflammatory eosinophilic and T-cell infiltrate and to IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 esophageal gene expression levels in patients with eosinophilic esophagitis (EE). Steroids 67-74 C-C motif chemokine ligand 26 Homo sapiens 206-211 18844613-6 2008 RESULTS: A significant decrease in the eosinophil infiltrate and in CD8(+) T-cell density was observed in the esophageal epithelium from the patients upon steroid treatment. Steroids 155-162 CD8a molecule Homo sapiens 68-71 18677278-11 2008 Dividing up the patients into those suffering from a steroid-responsive anosmia (SRA) and those without benefit from initial systemic steroids (non-SRA), the topical treatment led to a significant difference between the two groups with benefit toward the non-SRA group (P < .001). Steroids 53-60 steroid receptor RNA activator 1 Homo sapiens 81-84 18677278-13 2008 Furthermore, in non-SRA patients we found even better results with steroids in combination with neomycin as a topical therapy. Steroids 67-75 steroid receptor RNA activator 1 Homo sapiens 20-23 18426392-2 2008 This chemical transformation is an obligatory reaction in the biosynthesis of steroid hormones and follows the oxidation of 3beta-hydroxysteroids catalysed by 3beta-HSD (3beta-hydroxysteroid dehydrogenase). Steroids 78-94 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 159-168 18426392-2 2008 This chemical transformation is an obligatory reaction in the biosynthesis of steroid hormones and follows the oxidation of 3beta-hydroxysteroids catalysed by 3beta-HSD (3beta-hydroxysteroid dehydrogenase). Steroids 78-94 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 170-204 18426392-10 2008 The results indicate that the lower isomerase activity of 3beta-HSD is insufficient for maximal rate of cellular sex hormone production and identify hGSTA3-3 as a possible target for pharmaceutical intervention in steroid hormone-dependent diseases. Steroids 214-229 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 58-67 18401014-0 2008 Coexpression of adrenomedullin and its receptors in the reproductive system of the rat: effects on steroid secretion in rat ovary. Steroids 99-106 adrenomedullin Rattus norvegicus 16-30 18691071-9 2008 However, both steroid therapy and allergen specific immunotherapy are known to elevate endogenous IL-10 levels, which may account for their efficacy, suggesting that further study of IL-10 as a target for treatment of airway inflammatory diseases such as asthma and COPD is warranted. Steroids 14-21 interleukin 10 Homo sapiens 98-103 18691071-9 2008 However, both steroid therapy and allergen specific immunotherapy are known to elevate endogenous IL-10 levels, which may account for their efficacy, suggesting that further study of IL-10 as a target for treatment of airway inflammatory diseases such as asthma and COPD is warranted. Steroids 14-21 interleukin 10 Homo sapiens 183-188 18385421-1 2008 Mutations in the NPHS2 gene, which encodes podocin, are responsible for some cases of sporadic and familial autosomal recessive steroid-resistant nephrotic syndrome. Steroids 128-135 nephrosis 2, podocin Mus musculus 17-22 18385421-1 2008 Mutations in the NPHS2 gene, which encodes podocin, are responsible for some cases of sporadic and familial autosomal recessive steroid-resistant nephrotic syndrome. Steroids 128-135 nephrosis 2, podocin Mus musculus 43-50 18524870-2 2008 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mediates intracellular steroid exposure to mouse liver GR by prereceptor reactivation of GCs and is crucially dependent on hexose-6-phosphate dehydrogenase (H6PDH)-generating NADPH system. Steroids 14-21 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 44-55 18483855-9 2008 As to more generalized influences, the effect of gonadal steroids on the GFAP-reaction interpeduncular nucleus, an area not involved in hormonal regulatory mechanisms was studied. Steroids 57-65 glial fibrillary acidic protein Homo sapiens 73-77 18665078-1 2008 OBJECTIVES: The aim of this study was to investigate the expression of the 4 gene transcripts, steroidogenic factors 1 (SF-1) and 2 (SF-2), steroidogenic acute regulatory (StAR), and cytochrome P450 11A1, involved in the synthesis of steroid hormones in normal human pancreas. Steroids 234-250 splicing factor 1 Homo sapiens 75-131 18497332-8 2008 Overall, these findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver. Steroids 152-160 solute carrier family 51, alpha subunit Mus musculus 71-79 18269350-2 2008 High-affinity TSPO ligands are best known for their ability to stimulate cholesterol transport in organs synthesizing steroids and bile salts, although they modulate other physiological functions, including cell proliferation, apoptosis and calcium-dependent transepithelial ion secretion. Steroids 118-126 translocator protein Rattus norvegicus 14-18 18539027-5 2008 The unnatural 7-oxa-steroids were orally active in a rat complement C3 assay and showed comparable pharmacokinetic and metabolic profiles to those of the natural steroid, mifepristone. Steroids 20-27 complement C3 Rattus norvegicus 57-70 18403486-10 2008 These results demonstrate the stimulatory role played by glucocorticoids in alphaGSU gene expression in the pituitary gonadotrope, in contrast to repression in placental cells, and highlight the tissue-specific nature of steroid hormone action. Steroids 221-236 glycoprotein hormones, alpha subunit Mus musculus 76-84 18454446-5 2008 RESULTS: Here, we show that beta(2)-AR was transiently down-regulated both at mRNA- and protein levels when hormone-sensitive prostate cancer cells, LNCaP, were cultured in steroid stripped medium (charcoal-stripped fetal calf serum) or when the cells were treated with the anti-androgen, bicalutamide (Casodex). Steroids 173-180 adrenoceptor beta 2 Homo sapiens 28-38 18274826-0 2008 Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan. Steroids 44-51 solute carrier family 22 member 4 Homo sapiens 15-22 18274826-1 2008 PURPOSE: We investigated the association between steroid responsiveness and single nucleotide polymorphisms of SLC22A4/A5 located within inflammatory bowel disease 5 locus. Steroids 49-56 solute carrier family 22 member 4 Homo sapiens 111-118 18202129-7 2008 The fact that there were clear differences in the number of NVT KiSS-1 neurons between the fish under the breeding and nonbreeding conditions strongly suggests that the steroid-sensitive changes in the KiSS-1 mRNA expression in the NVT occur physiologically, according to the changes in the reproductive state. Steroids 169-176 metastasis-suppressor KiSS-1 Oryzias latipes 64-70 18202129-7 2008 The fact that there were clear differences in the number of NVT KiSS-1 neurons between the fish under the breeding and nonbreeding conditions strongly suggests that the steroid-sensitive changes in the KiSS-1 mRNA expression in the NVT occur physiologically, according to the changes in the reproductive state. Steroids 169-176 metastasis-suppressor KiSS-1 Oryzias latipes 202-208 18202134-5 2008 Therefore, we first determined whether Afp(-/-) females are capable of showing a steroid-induced preovulatory LH surge by FOS/GnRH1 immunohistochemistry and RIA of plasma LH levels. Steroids 81-88 alpha fetoprotein Mus musculus 39-42 18258681-12 2008 Our findings demonstrate that 1) blockade of preoptic/hypothalamic K(ATP) channels produces an acceleration of the GnRH pulse generator in a steroid-dependent manner and 2) E(2)+P stimulate Kir6.2 gene expression in the POA. Steroids 141-148 potassium inwardly-rectifying channel, subfamily J, member 11 Rattus norvegicus 190-196 18288100-1 2008 Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome. Steroids 118-125 nephrosis 2, podocin Mus musculus 17-22 18288100-1 2008 Mutations in the NPHS2 gene, encoding podocin, are responsible for familial autosomal recessive and sporadic cases of steroid-resistant nephrotic syndrome. Steroids 118-125 nephrosis 2, podocin Mus musculus 38-45 18555874-0 2008 [Steroid treatment in four cases of anti-GAD cerebellar ataxia]. Steroids 1-8 glutamate decarboxylase 1 Homo sapiens 41-44 18353099-8 2008 Eip63F-1 is one of many genes controlled by the steroid hormone 20-hydroxyecdysone that appear to be co-regulated by Fkh. Steroids 48-63 fork head Drosophila melanogaster 117-120 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 progesterone receptor Mus musculus 184-205 18280760-3 2008 These events in early pregnancy are tightly regulated by the steroid hormones, estrogen (E2) and progesterone (P4), through their cognate receptors, the estrogen receptor (ER) and the progesterone receptor (PR), respectively. Steroids 61-68 progesterone receptor Mus musculus 207-209 18367987-1 2008 Digoxin-like immunoreactive factor (DLIF) and ouabain-like factor (OLF) are the mammalian counterparts to the plant-derived cardiotonic steroids digoxin and ouabain. Steroids 136-144 transmembrane O-mannosyltransferase targeting cadherins 1 Homo sapiens 67-70 18208554-5 2008 Using the real-time reverse transcription-polymerase chain reaction (RT-PCR), we found that the expression of KiSS-1 and GPR54 is differentially regulated by steroids. Steroids 158-166 KiSS-1 metastasis-suppressor Rattus norvegicus 110-116 18626730-9 2008 CONCLUSIONS: Downregulation of CRYAA, SOD1, and TPI1, observed here after a short period of DEX-induced ocular hypertension, may be involved in the onset of neural damage in steroid-induced glaucoma. Steroids 174-181 triosephosphate isomerase 1 Rattus norvegicus 48-52 18069123-4 2008 FAT KiSS-1 expression was sensitive to sex steroids and to nutritional status. Steroids 43-51 KiSS-1 metastasis-suppressor Rattus norvegicus 4-10 18197253-6 2008 By means of ex vivo experiments, we showed that mitochondrial maximal steroidogenesis occurred as a result of the mutual action of steroidogenic acute regulatory (StAR) protein -a key regulatory component in steroid biosynthesis-, active ERK1/2 and PKA. Steroids 70-77 mitogen-activated protein kinase kinase kinase 14 Mus musculus 249-252 17592733-7 2008 Furthermore, IGF-I levels accurately reflected growth rate prior to elevations in sex steroids, suggesting that IGF-I may provide an endocrine signal between the somatotropic and reproductive axes that growth rate and/or size is sufficient to initiate gonad development. Steroids 86-94 insulin-like growth factor I Oncorhynchus mykiss 112-117 18441515-2 2008 When expressed in Xenopus oocytes, UST1r mediated uptake of ochratoxin A (OTA; K(m) = 1.0 microM) and sulfate conjugates of steroids, such as estrone-3-sulfate (ES; K(m) = 3.1 microM) and dehydroepiandrosterone sulfate (DHEAS; K(m) = 2.1 microM) in a sodium-independent manner. Steroids 124-132 solute carrier family 22, member 25 Rattus norvegicus 35-40 19003600-1 2008 The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin. Steroids 187-203 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 32-62 19003600-1 2008 The substrate spectrum of human UDP-glucuronosyltransferase 1A (UGT1A) proteins includes the glucuronidation of non-steroidal anti-inflammatory drugs, anticonvulsants, chemotherapeutics, steroid hormones, bile acids, and bilirubin. Steroids 187-203 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 64-69 17434649-7 2008 Furthermore, the C-17 spiro-epoxide analogues (ent-5 and ent-6) of ent-3 and ent-4, respectively, have activities comparable to those of steroids 1 and 2. Steroids 137-145 solute carrier family 29 member 3 Homo sapiens 67-72 17561380-2 2008 The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been demonstrated to be involved in the process of steroid biosynthesis, in peripheral steroidogenic tissues as well as in glia cells in the brain. Steroids 158-165 translocator protein Rattus norvegicus 11-31 17561380-2 2008 The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been demonstrated to be involved in the process of steroid biosynthesis, in peripheral steroidogenic tissues as well as in glia cells in the brain. Steroids 158-165 translocator protein Rattus norvegicus 33-37 17561380-2 2008 The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been demonstrated to be involved in the process of steroid biosynthesis, in peripheral steroidogenic tissues as well as in glia cells in the brain. Steroids 158-165 translocator protein Rattus norvegicus 62-101 18296905-9 2008 Data from this study show that PPARgamma and VEGFR-2 represent additional targets by which sex steroid estrogen and plant-derived phytoestrogens may, at certain doses, differentially regulate endometrial functions. Steroids 95-102 peroxisome proliferator-activated receptor gamma Rattus norvegicus 31-40 17901197-7 2008 Consistent with the clinical situation, the addition of a beta(2)-adrenoceptor agonist to a glucocorticoid is steroid-sparing in that maximal GRE-dependent responses, evoked by glucocorticoid, are achieved at approximately 10-fold lower concentrations in the presence of beta(2)-adrenoceptor agonist. Steroids 110-117 adrenoceptor beta 2 Homo sapiens 58-78 18193544-3 2008 Steroids bind to nuclear receptor in the nucleus for genomic actions, and also membrane-associated receptors which include nuclear receptor itself or GPCR(G protein-coupled receptor) followed by the activation of second messengers. Steroids 0-8 vomeronasal 1 receptor 17 pseudogene Homo sapiens 150-154 18269111-12 2008 The patient with mild symptoms of CTS can be managed with conservative treatment, particularly local injection of steroids. Steroids 114-122 transthyretin Homo sapiens 34-37 17916741-1 2007 Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, secreted protein that has been extensively studied from the standpoint of its structure and molecular biology. Steroids 37-44 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 28-30 17916741-7 2007 The tissue-specific expression of the UG gene is regulated by several steroid hormones, although a nonsteroid hormone, prolactin, further augments its expression in the uterus. Steroids 70-86 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 38-40 17990087-4 2007 While ABCG1, ABCG4 and ABCG5/8 are involved in the ATP-dependent translocation of steroids and, possibly, other lipids, ABCG2 (also termed the breast cancer resistance protein) has been identified as a multidrug transporter that confers resistance on tumor cells. Steroids 82-90 ATP binding cassette subfamily G member 4 Homo sapiens 13-18 17996055-1 2007 BACKGROUND: The initial steps of stem Leydig cell differentiation into steroid producing progenitor cells are thought to take place independent of luteinizing hormone (LH), under the influence of locally produced factors such as leukaemia inhibitory factor (LIF), platelet derived growth factor A and stem cell factor. Steroids 71-78 LIF, interleukin 6 family cytokine Rattus norvegicus 229-256 17996055-1 2007 BACKGROUND: The initial steps of stem Leydig cell differentiation into steroid producing progenitor cells are thought to take place independent of luteinizing hormone (LH), under the influence of locally produced factors such as leukaemia inhibitory factor (LIF), platelet derived growth factor A and stem cell factor. Steroids 71-78 LIF, interleukin 6 family cytokine Rattus norvegicus 258-261 17686889-10 2007 In contrast, the expression of hepatic SULT2B1, which catalyzes the second stage of steroid catabolism, was decreased in high-androstenone Duroc animals (P < 0.05), but not in high-androstenone N. Landrace animals. Steroids 84-91 sulfotransferase family 2B member 1 Sus scrofa 39-46 17975261-5 2007 In this study, we examined whether SF-1 could transform human BMCs into steroidogenic cells and compared the steroid profile of these cells with that of mouse steroidogenic BMCs. Steroids 72-79 splicing factor 1 Homo sapiens 35-39 17975261-7 2007 Such a mixed character of adrenal and gonadal steroid production in human BMCs was supported by the expressions of P450scc, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), P450c21, P450c11, P450c17, 17beta-HSD, and P450arom mRNAs. Steroids 46-53 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 124-158 17975261-7 2007 Such a mixed character of adrenal and gonadal steroid production in human BMCs was supported by the expressions of P450scc, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), P450c21, P450c11, P450c17, 17beta-HSD, and P450arom mRNAs. Steroids 46-53 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 181-188 17715402-9 2007 Considering that first, the D ring contains the only structural difference between PS and DHEAS, and second, the strongest chemical and steric effects of a mutation are likely to be felt in the local environment of the altered residues, this result implies that the steroid D ring may contact M1 near the mutated residues. Steroids 266-273 sulfotransferase family 2A member 1 Homo sapiens 90-95 17595226-3 2007 Recently, the hypothalamic KiSS-1/GPR54 system has emerged as a fundamental regulator of the gonadotropic axis, which conveys the modulatory actions of sex steroids to GnRH neurons. Steroids 156-164 KiSS-1 metastasis-suppressor Mus musculus 27-33 17595226-3 2007 Recently, the hypothalamic KiSS-1/GPR54 system has emerged as a fundamental regulator of the gonadotropic axis, which conveys the modulatory actions of sex steroids to GnRH neurons. Steroids 156-164 KISS1 receptor Mus musculus 34-39 17890294-3 2007 Differences in steroid secretion are largely due to the expression of 21-hydroxylase (CYP21A1) and 11beta-hydroxylase (CYP11B1) activity in the adrenal. Steroids 15-22 cytochrome P450, family 11, subfamily b, polypeptide 1 Mus musculus 119-126 17761811-0 2007 microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Steroids 76-91 mir-14 stem loop Drosophila melanogaster 9-15 17692313-7 2007 We therefore propose that the signal-dependent co-localization of Sgk and Erk/MAPK mediated by importin-alpha represents a new pathway of signal integration between steroid and serum/growth factor-regulated pathways. Steroids 165-172 serum/glucocorticoid regulated kinase 1 Homo sapiens 66-69 17525285-1 2007 Chronic inflammatory diseases often have residual CD8(+) T-cell infiltration despite treatment with systemic corticosteroids, which suggests divergent steroid responses between CD4(+) and CD8(+) cells. Steroids 116-123 CD8a molecule Homo sapiens 188-191 17525285-4 2007 DEX responses were functionally impaired in CD8(+) compared with CD4(+) cells when using mitogen-activated protein kinase phosphatase (1 hour; P = .02) and interleukin 10 mRNA (24 hours; P = .004) induction as a readout of steroid-induced transactivation. Steroids 223-230 CD8a molecule Homo sapiens 44-47 17525285-9 2007 The data indicate refractory steroid-induced transactivation but similar steroid-induced transrepression of CD8(+) cells compared with CD4(+) cells caused by decreased levels of the histone acetyltransferase ATF2. Steroids 73-80 CD8a molecule Homo sapiens 108-111 17845639-3 2007 We describe four successful cases of steroid withdrawal in adult patients who had living-donor liver transplantation from ABO-incompatible donors. Steroids 37-44 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 122-125 17763384-0 2007 Initial steroid bolus injection promotes vigorous CD8+ alloreactive responses toward early graft acceptance immediately after liver transplantation in humans. Steroids 8-15 CD8a molecule Homo sapiens 50-53 17763384-2 2007 This study aims to clarify how initial steroid bolus (ISB) injection at reperfusion influences the kinetics of CD8(+) alloreactive immune responses immediately after living donor liver transplantation (LDLT). Steroids 39-46 CD8a molecule Homo sapiens 111-114 17595319-2 2007 Steroid- and bile acid-sulfotransferase (SULT2A1) promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutic drugs. Steroids 144-152 sulfotransferase family 2A member 1 Homo sapiens 41-48 17928160-0 2007 Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats. Steroids 12-20 brain-derived neurotrophic factor Rattus norvegicus 61-94 17928160-0 2007 Neuroactive steroids modulate HPA axis activity and cerebral brain-derived neurotrophic factor (BDNF) protein levels in adult male rats. Steroids 12-20 brain-derived neurotrophic factor Rattus norvegicus 96-100 17928160-4 2007 In this systematic in vivo study, we showed that the principal neuroactive steroids, namely dehydroepiandrosterone (DHEA), pregnenolone (PREG) and their sulfate esters (DHEA-S and PREG-S), along with allopregnanolone (ALLO), stimulated HPA axis activity, while also modulating central BDNF contents. Steroids 75-83 brain-derived neurotrophic factor Rattus norvegicus 285-289 17928160-10 2007 In conclusion, these results highly suggest that part of the HPA axis and antidepressant effects of neuroactive steroids could be mediated by BDNF, particularly at the amygdala level. Steroids 112-120 brain-derived neurotrophic factor Rattus norvegicus 142-146 17324425-6 2007 On the latter, the KiSS-1 neuron has been proposed as key intermediary element for the negative and positive feedback effects of sex steroids on gonadotropin secretion. Steroids 133-141 KiSS-1 metastasis suppressor Homo sapiens 19-25 17591924-1 2007 A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death. Steroids 15-30 reaper Drosophila melanogaster 183-186 17492653-0 2007 The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. Steroids 91-99 oxytocin/neurophysin I prepropeptide Homo sapiens 14-22 17490617-1 2007 This study examined the relationship between steroid treatment and CD163-mediated downstream pathways linked to inflammatory resolution. Steroids 45-52 CD163 molecule Homo sapiens 67-72 17490617-8 2007 Our results demonstrated up-regulation of CD163 expression on the monocyte surface by steroid treatment. Steroids 86-93 CD163 molecule Homo sapiens 42-47 17490617-9 2007 Steroid treatment was suggested to facilitate CD163-mediated endocytosis of hemoglobin to monocytes/macrophages and thereby induce acceleration of HO-1 synthesis. Steroids 0-7 CD163 molecule Homo sapiens 46-51 17434470-7 2007 Thus, in the absence of disease-specific markers, the anti-HSP70 IgG WB assay could be of use to detect patients with idiopathic SNHL who might benefit from steroid treatment. Steroids 157-164 heat shock protein family A (Hsp70) member 4 Homo sapiens 59-64 17533573-3 2007 Immunohistochemistry of human testes and ovaries showed an expression of hYjeF_N3-19p13.11 only in Leydig cells and theca cells, respectively, indicating a role in steroid hormone metabolism. Steroids 164-179 YjeF N-terminal domain containing 3 Homo sapiens 73-81 17482806-1 2007 Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR). Steroids 20-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 101-119 17482806-1 2007 Vitamin D is a seco-steroid hormone with multiple actions in the brain, mediated through the nuclear vitamin D receptor (VDR). Steroids 20-27 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 121-124 17218406-4 2007 In these studies, we used three inhibitors of enzymes involved in steroid production: aminoglutethimide and ketoconazole, acting on cytochrome P450 side-chain cleavage (P450scc) located at the mitochondria, and epostane, acting on 3beta-hydroxysteroid dehydrogenase located at the endoplasmic reticulum. Steroids 66-73 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 169-176 17446966-7 2007 The EC and serum ECP levels declined soon after oral steroid treatment, rebounding to initial levels during inhalation treatment. Steroids 53-60 ribonuclease A family member 3 Homo sapiens 17-20 17446966-8 2007 The decrease in ECP level was positively correlated with the decrease in ECs with oral steroid treatment (r(2) = 0.28, p=0.016). Steroids 87-94 ribonuclease A family member 3 Homo sapiens 16-19 17470679-3 2007 STS hydrolyzes steroid sulfates, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS), to estrone and DHEA, which can be converted to steroids with potent estrogenic properties, that is, estradiol and androstenediol, respectively. Steroids 148-156 sulfotransferase family 2A member 1 Homo sapiens 93-98 17470679-8 2007 Unexpectedly, serum androstenedione concentrations also decreased by up to 86%, showing that this steroid, which is the main substrate for the aromatase in postmenopausal women, is derived mainly from the peripheral conversion of DHEAS. Steroids 98-105 sulfotransferase family 2A member 1 Homo sapiens 230-235 17151352-0 2007 Steroid control of gonadotropin-releasing hormone secretion: associated changes in pro-opiomelanocortin and preproenkephalin messenger RNA expression in the ovine hypothalamus. Steroids 0-7 pro-opiomelanocortin Ovis aries 83-103 17151352-2 2007 We used in situ hybridization histochemistry to determine whether steroid-induced changes in GnRH/LH release in the female sheep are associated with changes in the cellular mRNA content of the precursors for beta-endorphin (pro-opiomelanocortin; POMC) and met-enkephalin (pre-proenkephalin; PENK). Steroids 66-73 pro-opiomelanocortin Ovis aries 224-244 17151352-2 2007 We used in situ hybridization histochemistry to determine whether steroid-induced changes in GnRH/LH release in the female sheep are associated with changes in the cellular mRNA content of the precursors for beta-endorphin (pro-opiomelanocortin; POMC) and met-enkephalin (pre-proenkephalin; PENK). Steroids 66-73 pro-opiomelanocortin Ovis aries 246-250 17151352-7 2007 Further, the increase in POMC was restricted to regions of the arcuate nucleus that contain steroid sensitive beta-endorphin neurons. Steroids 92-99 pro-opiomelanocortin Ovis aries 25-29 17126340-12 2007 CONCLUSION(S): The results of the current investigation showed that CD9 was differentially expressed in the uterus depending on the stage of implantation and was upregulated in ovarian steroid hormone-dependent manner, implicating multiple roles of CD9 in the regulation of embryo implantation during the peri-implantation period. Steroids 185-200 CD9 antigen Mus musculus 68-71 17126340-12 2007 CONCLUSION(S): The results of the current investigation showed that CD9 was differentially expressed in the uterus depending on the stage of implantation and was upregulated in ovarian steroid hormone-dependent manner, implicating multiple roles of CD9 in the regulation of embryo implantation during the peri-implantation period. Steroids 185-200 CD9 antigen Mus musculus 249-252 17182978-4 2007 Because 24-hydroxylation by CYP24 would rapidly degrade the steroid hormone in the course of therapy, the enzyme activity in tumor cells should be inhibited. Steroids 60-75 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 28-33 17033905-7 2007 RESULTS: AIS-6 scores were significantly related to female sex, educational level, income, smoking, body mass index (BMI), COPD, steroid use, and hospitalization history in bivariate analyses. Steroids 129-136 sialic acid acetylesterase Homo sapiens 9-14 17203231-11 2007 Our results suggest that the expression of ERalpha, ERbeta and GPR30 are influenced by sex steroids and might play a role in the response of cells to 17beta-estradiol and antiestrogens but are not the only factors involved in this process. Steroids 91-99 G protein-coupled estrogen receptor 1 Homo sapiens 63-68 17043388-2 2007 This study was conducted to evaluate the effects of exogenous sex steroids on the blood leptin concentrations in ewes in the non-breeding season. Steroids 66-74 leptin Bos taurus 88-94 17196738-1 2007 Steroidogenic factor (SF1, NR5A1, Ad4BP) is an orphan nuclear receptor that is essential for steroid hormone-biosynthesis and endocrine development. Steroids 93-108 splicing factor 1 Homo sapiens 22-25 17255289-2 2007 We evaluated the efficacy, safety, and tolerability of hormonal chemoprevention with a gonadotropin-releasing hormone agonist (GnRHA) with low-dose add-back steroids in BRCA1(mut) carriers. Steroids 157-165 BRCA1 DNA repair associated Homo sapiens 169-174 17786633-4 2007 Furthermore, cotransfections with 3 beta HSD revealed that one CYP17 isoform strongly favours the Delta(5) steroid pathway. Steroids 107-114 cytochrome P450 family 17 subfamily A member 1A Capra hircus 63-68 18543432-5 2007 The ovarian steroid progesterone, acting via the secreted factor Wnt4, is known to be essential for side branching of the mammary gland. Steroids 12-19 Wnt family member 4 Homo sapiens 65-69 17018696-6 2007 We conclude that anti-Ma2 encephalitis may present with mostly isolated EDS and that it may respond to steroids despite old age and the presence of an untreated lung cancer. Steroids 103-111 PNMA family member 2 Homo sapiens 22-25 18154121-0 2007 [Effect of apolipoprotein A-1 containing steroid hormones on DNA and protein biosynthesis in cells of ascitic hepatoma HA-1]. Steroids 41-57 apolipoprotein A-I Mus musculus 11-29 18154121-3 2007 Apolipoprotein A-1 complexes serve as a vehicle for steroids penetration into cells to influence protein biosynthesis. Steroids 52-60 apolipoprotein A-I Mus musculus 0-18 17055487-4 2006 Our results provide a new aspect of biochemical and functional characterization of the ABCG5/ABCG8 proteins and their possible involvement in steroid hormone transport or regulation. Steroids 142-157 ATP binding cassette subfamily G member 8 Homo sapiens 93-98 16844298-8 2006 These results suggested that K is involved in steroid production in the testis through the regulation of Cyp11a. Steroids 46-53 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 105-111 16980658-5 2006 The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Steroids 117-124 CD8a molecule Homo sapiens 54-57 16980658-5 2006 The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Steroids 117-124 CD8a molecule Homo sapiens 65-68 16980658-5 2006 The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Steroids 156-163 CD8a molecule Homo sapiens 54-57 16980658-5 2006 The ratio of cells double positive for granulysin and CD8 to all CD8 cells at endomysial sites was notably higher in steroid-resistant polymyositis than in steroid-responsive polymyositis and IBM. Steroids 156-163 CD8a molecule Homo sapiens 65-68 16980658-6 2006 CONCLUSION: Granulysin expression in CD8 cells seems to be correlated with steroid resistance in polymyositis. Steroids 75-82 CD8a molecule Homo sapiens 37-40 16889589-1 2006 OBJECTIVE: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) have been demonstrated in post-traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects. Steroids 213-221 sulfotransferase family 2A member 1 Homo sapiens 94-99 16949386-0 2006 Characterizing variation in sex steroid hormone pathway genes in women of 4 races/ethnicities: the Study of Women"s Health Across the Nation (SWAN). Steroids 32-47 RNA binding motif protein 12 Homo sapiens 142-146 16815029-3 2006 IGF-IR levels are tightly regulated by the concerted action of secreted (e.g. peptide and steroid hormones, growth factors and cytokines) and cellular (e.g. transcription factors, oncogenes and tumor suppressors) factors. Steroids 90-106 insulin like growth factor 1 receptor Homo sapiens 0-6 16822554-3 2006 Many functions are associated directly or indirectly with the PBR, including the regulation of cholesterol transport and the synthesis of steroid hormones, porphyrin transport and heme synthesis, apoptosis, cell proliferation, anion transport, regulation of mitochondrial functions and immunomodulation. Steroids 138-154 translocator protein Homo sapiens 62-65 16763204-8 2006 Given that the nvd family is evolutionally conserved, these results suggest that Nvd is an essential regulator of cholesterol metabolism or trafficking in steroid synthesis across animal phyla. Steroids 155-162 neverland Drosophila melanogaster 15-18 16763204-8 2006 Given that the nvd family is evolutionally conserved, these results suggest that Nvd is an essential regulator of cholesterol metabolism or trafficking in steroid synthesis across animal phyla. Steroids 155-162 neverland Drosophila melanogaster 81-84 16774502-9 2006 Taken together with previous findings, these data suggest that a subpopulation of arcuate nucleus neurones coexpressing DYN and NKB mediate the negative feedback influence of progesterone on pulsatile GnRH secretion in the ewe and may also be involved in other feedback actions of gonadal steroids. Steroids 289-297 tachykinin-3 Ovis aries 128-131 16132061-8 2006 Among neuroactive steroids, pregnanolone and allopregnanolone, positive modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor, produced StD. Steroids 18-26 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 122-129 16573780-1 2006 Association of -1082 AA low producer IL-10 genotype with steroid dependency. Steroids 57-64 interleukin 10 Homo sapiens 37-42 16573780-8 2006 In a stratified analysis, a highly significant association between the -1082 AA IL-10 genotype and the steroid dependency was observed in IBD (p < 0.0001), contributing both UC (p = 0.004) and CD (p = 0.003) to this association. Steroids 103-110 interleukin 10 Homo sapiens 80-85 16573780-11 2006 The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). Steroids 4-11 interleukin 10 Homo sapiens 119-124 16573780-11 2006 The steroid-dependent phenotype correlated in UC with extensive disease (p = 0.010) and with the low producer -1082 AA IL-10 genotype (p = 0.002) and in CD with penetrating disease (p = 0.010), arthritis (p = 0.011), and the -1082 AA IL-10 genotype (p = 0.006). Steroids 4-11 interleukin 10 Homo sapiens 234-239 16573780-12 2006 CONCLUSIONS: The main conclusion is that carriage of the -1082 AA IL-10 genotype (low producer) is a relevant risk factor for developing steroid-dependent IBD. Steroids 137-144 interleukin 10 Homo sapiens 66-71 16685466-3 2006 In this study, Hep27 was expressed as a His(6) fusion protein, and subjected to a substrate screen, using a compound library of SDR substrates, comprising steroids, retinoids, sugars and carbonyl compounds. Steroids 155-163 dehydrogenase/reductase 2 Homo sapiens 15-20 16554373-3 2006 Here we identify an influence on the circadian oscillation of the clock protein PER2, endogenous changes in ovarian steroids, within two nuclei of the limbic forebrain: the oval nucleus of the bed nucleus of the stria terminalis and central nucleus of the amygdala. Steroids 116-124 period circadian regulator 2 Homo sapiens 80-84 16371448-2 2006 Our previous report described the temporal steroid patterns during pharmacokinetic (PK) studies with dexamethasone (DEX) where doses of six 1 micromol/kg injections were given during gestational ages 18 to 20 days in rats. Steroids 43-50 SIX homeobox 1 Rattus norvegicus 136-141 16356628-7 2006 Zebrafish with a block in cyp11a1 gene function has an earlier defect, presumably because it lacks adequate maternal steroid supply. Steroids 117-124 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 26-33 16529801-6 2006 Together, these results define the first steroid hormones in nematodes as ligands for an invertebrate orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to molecular mechanism, is conserved from worms to humans. Steroids 41-48 estrogen related receptor beta Homo sapiens 102-125 16244359-9 2006 Since AIB1 appears to modulate the effect of endogenous hormones via the estrogen receptor, and smoking affects circulating hormone levels, these results support evidence that steroid hormones play an important role in breast carcinogenesis in BRCA1 mutation carriers, and suggest mechanisms for developing novel cancer prevention strategies for BRCA1 mutation carriers. Steroids 176-192 BRCA1 DNA repair associated Homo sapiens 244-249 16508124-1 2006 Dehydroepiandrosterone-sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone, is the most abundant steroids in human, although its biological activities are seemingly weak. Steroids 107-115 sulfotransferase family 2A member 1 Homo sapiens 32-38 16533772-1 2006 Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone-regulated secreted serine protease differentially expressed in ovarian carcinoma. Steroids 64-79 kallikrein related peptidase 8 Homo sapiens 6-18 16533772-1 2006 Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone-regulated secreted serine protease differentially expressed in ovarian carcinoma. Steroids 64-79 keratin 8 Homo sapiens 20-23 16533772-1 2006 Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone-regulated secreted serine protease differentially expressed in ovarian carcinoma. Steroids 64-79 opsin 5 Homo sapiens 24-33 16533772-1 2006 Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone-regulated secreted serine protease differentially expressed in ovarian carcinoma. Steroids 64-79 kallikrein related peptidase 8 Homo sapiens 34-40 16533772-1 2006 Human kallikrein 8 (hK8/neuropsin/ovasin; encoded by KLK8) is a steroid hormone-regulated secreted serine protease differentially expressed in ovarian carcinoma. Steroids 64-79 kallikrein related peptidase 8 Homo sapiens 53-57 16443195-1 2006 This study describes the localization and pattern of expression of estradiol and progesterone receptors as well as key enzymes for steroid synthesis (i.e. P450 side-chain-cleavage--P450scc, and P450 aromatase--P450Aro) in the carotid body (CB) and superior cervical ganglion (SCG) of adult, newborn and late fetal male rats, using immunohistochemistry, Western blot and real-time RT-PCR. Steroids 131-138 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 181-188 16293942-1 2006 We examined the relations between plasma insulin-like growth factor (IGF) -I concentrations during treatment with CIDR-based or Ovsynch protocol for timed AI and conception and plasma steroid concentrations in early postpartum Japanese Black beef cows. Steroids 184-191 IGFI Bos taurus 41-76 16261611-2 2006 This study was to examine snail expression in mouse uterus during early pregnancy and its regulation under pseudopregnancy, delayed implantation, steroid hormone treatment, and artificial decidualization by in situ hybridization and immunohistochemistry. Steroids 146-161 snail family zinc finger 1 Mus musculus 26-31 16291758-10 2006 With the characterization of HIC-5 as a binding partner of the alternatively spliced exon in LEF/TCF transcription factors, we identified a novel molecular mechanism in the dialog of steroid and canonical Wnt signaling that is LEF/TCF subtype-dependent. Steroids 183-190 transforming growth factor beta 1 induced transcript 1 S homeolog Xenopus laevis 29-34 16009527-1 2006 The enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) is essential in the synthesis of all steroids by cleaving dehydroepiandrosterone to androstenedione. Steroids 95-103 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 11-45 16009527-1 2006 The enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) is essential in the synthesis of all steroids by cleaving dehydroepiandrosterone to androstenedione. Steroids 95-103 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 47-56 16009527-7 2006 The presence of 3beta-HSD immunoreactivity indicates that steroids are locally synthesized in the ram prostate. Steroids 58-66 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 16-25 16210373-0 2006 Female sex steroids increase adrenomedullin-induced vasodilation by increasing the expression of adrenomedullin2 receptor components in rat mesenteric artery. Steroids 11-19 adrenomedullin Rattus norvegicus 29-43 16210375-5 2006 In in vitro endometrial cell culture, EG-VEGF mRNA was detected in endometrial cells only in the presence of steroids, suggesting that EG-VEGF expression is highly dependent on the steroid hormones. Steroids 109-117 prokineticin 1 Homo sapiens 38-45 16210375-5 2006 In in vitro endometrial cell culture, EG-VEGF mRNA was detected in endometrial cells only in the presence of steroids, suggesting that EG-VEGF expression is highly dependent on the steroid hormones. Steroids 109-116 prokineticin 1 Homo sapiens 38-45 17525483-12 2006 An immunohistochemical evaluation of adrenal 4 binding protein (Ad4BP) or SF-1, a transcription factor of all steroidogenesis, can aid in this differential diagnosis because nuclear immunoreactivity for this transcription factor is relatively specific to steroid producing cells. Steroids 110-117 splicing factor 1 Homo sapiens 74-78 16079224-7 2006 The recessive lethal phenotype of NPC1a mutants can be partially rescued on a diet of high cholesterol or one that includes the insect steroid hormone 20-hydroxyecdysone. Steroids 135-150 Niemann-Pick type C-1a Drosophila melanogaster 34-39 15991246-8 2006 Our data might also be important for Kv4 channels in the brain and the cardiovascular system where rapid steroid effects are discussed in the context of prevention of cell death. Steroids 105-112 potassium voltage-gated channel subfamily C member 1 Homo sapiens 37-40 16622721-1 2006 To assess adrenal function with respect to the presence or absence of steroid therapy, we investigated differences in the blood levels of adrenocorticotropic hormone (ACTH) and dehydroepiandrosterone sulfate (DHEAS) in relation to steroid (prednisolone) administration in 123 patients with rheumatoid arthritis (RA). Steroids 231-238 sulfotransferase family 2A member 1 Homo sapiens 209-214 16622721-2 2006 Levels of ACTH and DHEAS were significantly lower in the steroid-treated group than in the non-treated group (ACTH: 11.79 pg/ml vs 27.92 pg/ml) (DHEAS: 418.12 ng/ml vs 883.91 ng/ml) (P<0.0001). Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 19-24 16622721-2 2006 Levels of ACTH and DHEAS were significantly lower in the steroid-treated group than in the non-treated group (ACTH: 11.79 pg/ml vs 27.92 pg/ml) (DHEAS: 418.12 ng/ml vs 883.91 ng/ml) (P<0.0001). Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 145-150 16741564-3 2006 In addition, unfolding evidence suggests that BRCA1 functions as a co-regulator for steroid hormone receptors and modulates steroid hormone action. Steroids 84-99 BRCA1 DNA repair associated Homo sapiens 46-51 16752799-5 2006 In cases of mutation in NPHS1 gene, causing congenital nephrotic syndrome of the Finnish type (CNF), resistance to steroid therapy occurs regularly and recurrence of proteinuria after renal transplantation is about 20-25%. Steroids 115-122 NPHS1 adhesion molecule, nephrin Homo sapiens 24-29 16752799-5 2006 In cases of mutation in NPHS1 gene, causing congenital nephrotic syndrome of the Finnish type (CNF), resistance to steroid therapy occurs regularly and recurrence of proteinuria after renal transplantation is about 20-25%. Steroids 115-122 NPHS1 adhesion molecule, nephrin Homo sapiens 95-98 15996825-0 2006 Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions. Steroids 16-24 brain-derived neurotrophic factor Rattus norvegicus 34-67 15996825-0 2006 Sex and ovarian steroids modulate brain-derived neurotrophic factor (BDNF) protein levels in rat hippocampus under stressful and non-stressful conditions. Steroids 16-24 brain-derived neurotrophic factor Rattus norvegicus 69-73 16166216-9 2005 In conclusion, we have demonstrated that the SK11 Sc cell line contains functional AR and ERbeta and that treatment of the cells with their respective steroids results in an increase in the amount of their mRNAs. Steroids 151-159 androgen receptor Mus musculus 83-85 16359393-5 2005 A steroid-inducible version of PKL [a fusion of PKL to the glucocorticoid receptor (PKL:GR)] was used to examine when PKL acts to repress expression of embryonic traits. Steroids 2-9 chromatin remodeling factor CHD3 (PICKLE) Arabidopsis thaliana 31-34 16359393-5 2005 A steroid-inducible version of PKL [a fusion of PKL to the glucocorticoid receptor (PKL:GR)] was used to examine when PKL acts to repress expression of embryonic traits. Steroids 2-9 chromatin remodeling factor CHD3 (PICKLE) Arabidopsis thaliana 48-51 16359393-5 2005 A steroid-inducible version of PKL [a fusion of PKL to the glucocorticoid receptor (PKL:GR)] was used to examine when PKL acts to repress expression of embryonic traits. Steroids 2-9 chromatin remodeling factor CHD3 (PICKLE) Arabidopsis thaliana 48-51 16359393-5 2005 A steroid-inducible version of PKL [a fusion of PKL to the glucocorticoid receptor (PKL:GR)] was used to examine when PKL acts to repress expression of embryonic traits. Steroids 2-9 chromatin remodeling factor CHD3 (PICKLE) Arabidopsis thaliana 48-51 16170380-3 2005 We previously showed that p66(Shc) protein level is upregulated by steroid hormones in human carcinoma cells and is higher in prostate cancer (PCa) specimens than adjacent noncancerous cells. Steroids 67-83 SHC adaptor protein 1 Homo sapiens 30-33 16259799-1 2005 BACKGROUND: Dehydroepiandrosterone sulphate (DHEAS) is a steroid that is increasingly being recognized as a potential drug of abuse in many countries. Steroids 57-64 sulfotransferase family 2A member 1 Homo sapiens 45-50 16230520-9 2005 Female sex steroids increased elastin deposition compared with control (control, 100%; 17beta-estradiol, 540+/-60%; progesterone, 290+/-40%; 17beta-estradiol plus progesterone, 400+/-80%, all P<0.01). Steroids 11-19 elastin Homo sapiens 30-37 16293774-7 2005 It is hypothesised that cytochrome b(5) promotes the cleavage by aligning the iron-oxygen complex attack onto the C(20) rather than the C(17) atom of the steroid substrate molecule. Steroids 154-161 mitochondrially encoded cytochrome b Homo sapiens 24-36 16139796-3 2005 The presence of binding sites for progesterone receptors in GnRH1, estrogen receptors in GnRH1 and GnRH2, and thyroid hormone receptors in GnRH1 and GnRH3 suggests direct action of steroid hormones on GnRH types. Steroids 181-197 progonadoliberin-2 Oreochromis niloticus 99-104 16139796-3 2005 The presence of binding sites for progesterone receptors in GnRH1, estrogen receptors in GnRH1 and GnRH2, and thyroid hormone receptors in GnRH1 and GnRH3 suggests direct action of steroid hormones on GnRH types. Steroids 181-197 gonadotropin-releasing hormone 3 Oreochromis niloticus 149-154 15976054-0 2005 Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats. Steroids 38-45 androgen receptor Mus musculus 62-79 15976054-11 2005 We conclude that THG is an anabolic steroid that binds to AR, activates AR-mediated signaling, promotes myogenesis in mesenchymal multipotent cells, and has anabolic and androgenic activity in vivo. Steroids 36-43 androgen receptor Rattus norvegicus 58-60 16105657-3 2005 Here, we report that cyclin D3 is a new interacting partner of vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and the fat-soluble vitamins A and D. The interaction was confirmed with methods of yeast two-hybrid system, in vitro binding analysis and in vivo co-immunoprecipitation. Steroids 142-158 vitamin D receptor Homo sapiens 63-81 16105657-3 2005 Here, we report that cyclin D3 is a new interacting partner of vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and the fat-soluble vitamins A and D. The interaction was confirmed with methods of yeast two-hybrid system, in vitro binding analysis and in vivo co-immunoprecipitation. Steroids 142-158 vitamin D receptor Homo sapiens 83-86 15998777-12 2005 TSH receptor antibody titers decreased during iv steroid administration (P < 0.001), and smoking had a strong impact on the therapy response (P < 0.001). Steroids 49-56 thyroid stimulating hormone receptor Homo sapiens 0-12 16126771-5 2005 Furthermore, the results of zymography revealed that steroid hormones regulated the activity of decidual-secreted matrix metalloproteinases (MMP)-2 and -9, in which E2 treatment up-regulated the MMP-9 activity. Steroids 53-69 matrix metallopeptidase 9 Homo sapiens 195-200 16054614-5 2005 PXR and CAR received their names because of steroid ligands that activate and inhibit their transcriptional activity, respectively. Steroids 44-51 nuclear receptor subfamily 1 group I member 3 Homo sapiens 8-11 16054614-8 2005 Because PXR and CAR are activated by numerous steroids and endocrine disrupters, it appears that these receptors protect the integrity of the endocrine system. Steroids 46-54 nuclear receptor subfamily 1 group I member 3 Homo sapiens 16-19 16054614-10 2005 Furthermore, PXR and CAR induce enzymes, such as the CYP2B and CYP3A family members, responsible for the metabolism of steroid and thyroid hormones and this may alter their normal physiological function. Steroids 119-126 nuclear receptor subfamily 1 group I member 3 Homo sapiens 21-24 16116793-0 2005 Comparison of the responsiveness of the pGL3 and pGL4 luciferase reporter vectors to steroid hormones. Steroids 85-101 succinate dehydrogenase complex subunit C Homo sapiens 40-44 16116793-0 2005 Comparison of the responsiveness of the pGL3 and pGL4 luciferase reporter vectors to steroid hormones. Steroids 85-101 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 49-53 16103446-1 2005 Carbonyl reductase (CBR) is a cytosolic NADPH-dependent oxidoreductase metabolizing prostaglandins, steroids, quinines, and anthracycline antibiotics. Steroids 100-108 carbonyl reductase 1 Homo sapiens 0-18 16103446-1 2005 Carbonyl reductase (CBR) is a cytosolic NADPH-dependent oxidoreductase metabolizing prostaglandins, steroids, quinines, and anthracycline antibiotics. Steroids 100-108 carbonyl reductase 1 Homo sapiens 20-23 16011488-6 2005 Hypothalamic KiSS-1 expression is regulated by circulating sex steroids. Steroids 63-71 KiSS-1 metastasis suppressor Homo sapiens 13-19 15967013-5 2005 Treatment with steroids induced complete resolution of the lip liner-associated dermatitis. Steroids 15-23 SMG1 nonsense mediated mRNA decay associated PI3K related kinase Homo sapiens 59-62 15987944-4 2005 This is the first report of an identified insect GPCR interacting with steroids. Steroids 71-79 Octopamine receptor in mushroom bodies Drosophila melanogaster 49-53 15885501-9 2005 The targets of Rsl regulation also vary between species, occurring in gene families with functions in steroid and xenobiotic metabolism (Cyp2d), reproduction (MUPs), and immunity (Slp). Steroids 102-109 cytochrome P450, 2d region Mus musculus 137-142 15870863-1 2005 Overexpression of the lipogenic enzyme fatty acid synthase (FAS) is a common molecular feature in subsets of sex-steroid-related tumors including breast carcinomas that is associated with poor prognosis. Steroids 113-120 fatty acid synthase Homo sapiens 39-58 15870863-1 2005 Overexpression of the lipogenic enzyme fatty acid synthase (FAS) is a common molecular feature in subsets of sex-steroid-related tumors including breast carcinomas that is associated with poor prognosis. Steroids 113-120 fatty acid synthase Homo sapiens 60-63 15876398-9 2005 For instance sex steroids, parathyroid hormone and some interleukins are known to exert their positive or negative effects on osteoclast differentiation via the RANK/RANKL/osteoprotegrin pathway. Steroids 17-25 TNF superfamily member 11 Homo sapiens 166-171 15870285-11 2005 In conclusion, dexamethasone antagonizes C/EBPbeta- and Nrf2-mediated GSTA2 gene induction via ligand-GR binding to the GRE, and steroid-mediated GSTA2 repression involves inactivation of C/EBPbeta and Nrf2 by SMRT recruited to steroid-GR complex. Steroids 129-136 glutathione S-transferase alpha 2 Rattus norvegicus 146-151 15870285-11 2005 In conclusion, dexamethasone antagonizes C/EBPbeta- and Nrf2-mediated GSTA2 gene induction via ligand-GR binding to the GRE, and steroid-mediated GSTA2 repression involves inactivation of C/EBPbeta and Nrf2 by SMRT recruited to steroid-GR complex. Steroids 228-235 CCAAT/enhancer binding protein beta Rattus norvegicus 41-50 15824177-1 2005 Vitamin D receptor (VDR), a member of the steroid/thyroid hormone nuclear receptor family, is bound by the steroid hormone 1,25-dihydroxyvitamin D3, which is thought to play a role in the etiology and progression of prostate cancer. Steroids 107-122 vitamin D receptor Homo sapiens 0-18 15824177-1 2005 Vitamin D receptor (VDR), a member of the steroid/thyroid hormone nuclear receptor family, is bound by the steroid hormone 1,25-dihydroxyvitamin D3, which is thought to play a role in the etiology and progression of prostate cancer. Steroids 107-122 vitamin D receptor Homo sapiens 20-23 15816945-10 2005 CONCLUSIONS: Women with more frequent seizures had alterations of their adrenal steroids characterized by an increase of cortisol and a decrease of DHEAS levels. Steroids 80-88 sulfotransferase family 2A member 1 Homo sapiens 148-153 15689952-8 2005 Loss of PARP-1 resulted in reversal of the neuroprotective activity by the female sex steroid, 17beta estradiol. Steroids 86-93 poly (ADP-ribose) polymerase family, member 1 Mus musculus 8-14 15876413-0 2005 Anabolic-androgenic steroid interaction with rat androgen receptor in vivo and in vitro: a comparative study. Steroids 20-27 androgen receptor Rattus norvegicus 49-66 15876413-2 2005 There are disagreements in the literature in regards to the interaction of anabolic steroids with the androgen receptor (AR) as revealed by competitive ligand binding assays in vitro using cytosolic preparations from prostate and skeletal muscle. Steroids 84-92 androgen receptor Rattus norvegicus 102-119 15876413-2 2005 There are disagreements in the literature in regards to the interaction of anabolic steroids with the androgen receptor (AR) as revealed by competitive ligand binding assays in vitro using cytosolic preparations from prostate and skeletal muscle. Steroids 84-92 androgen receptor Rattus norvegicus 121-123 15876413-3 2005 By use of tissue extracts, it has been shown that some anabolic steroids have binding affinities for the AR that are higher than that of the natural androgen testosterone, while others such as stanozolol and methanedienone have significantly lower affinities as compared with testosterone. Steroids 64-72 androgen receptor Rattus norvegicus 105-107 15876413-6 2005 Based on these results, we conclude that anabolic steroids with low affinity to AR in vitro, can in fact in vivo act on the AR to cause biological responses. Steroids 50-58 androgen receptor Rattus norvegicus 80-82 15876413-6 2005 Based on these results, we conclude that anabolic steroids with low affinity to AR in vitro, can in fact in vivo act on the AR to cause biological responses. Steroids 50-58 androgen receptor Rattus norvegicus 124-126 15690192-2 2005 Urine steroid profiling substantiated the diagnosis and DNA analysis of the epithelial sodium channel (ENaC) revealed a novel heterozygous beta ENaC mutation in the patient and in her hypertensive father. Steroids 6-13 sodium channel epithelial 1 subunit beta Homo sapiens 139-148 15751958-1 2005 Adrenodoxin (Adx), a [2Fe-2S] vertebrate-type ferredoxin, transfers electrons from the NADPH-dependent flavoprotein Adx reductase (AdR) to mitochondrial cytochrome P450 enzymes of the CYP11A and CYP11B families, which catalyze key reactions in steroid hormone biosynthesis. Steroids 244-259 ferredoxin reductase Bos taurus 116-129 15751958-1 2005 Adrenodoxin (Adx), a [2Fe-2S] vertebrate-type ferredoxin, transfers electrons from the NADPH-dependent flavoprotein Adx reductase (AdR) to mitochondrial cytochrome P450 enzymes of the CYP11A and CYP11B families, which catalyze key reactions in steroid hormone biosynthesis. Steroids 244-259 ferredoxin reductase Bos taurus 131-134 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 3 Homo sapiens 63-95 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 3 Homo sapiens 97-100 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 retinoid X receptor alpha Homo sapiens 162-181 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 retinoid X receptor alpha Homo sapiens 183-186 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Steroids 15-22 nuclear receptor subfamily 1 group I member 3 Homo sapiens 331-334 15750272-6 2005 After steroid therapy was restarted, there were improvements in her audibility, radial arterial pulsation, and levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and gamma-globulin), fibrinogen, interleukin-6, and RANTES (regulated on activation, normal T cell expressed and secreted). Steroids 6-13 C-C motif chemokine ligand 5 Homo sapiens 247-253 15536155-0 2005 Regulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium. Steroids 91-99 matrix metallopeptidase 9 Homo sapiens 14-40 15536155-8 2005 In proliferative explants, ovarian steroids slightly decreased MMP-9 mRNA. Steroids 35-43 matrix metallopeptidase 9 Homo sapiens 63-68 15536155-11 2005 We propose that endometrial MMP-9 activity is overall controlled by the ovarian steroids and locally adjusted through a network of modulators, including LEFTY-A. Steroids 80-88 matrix metallopeptidase 9 Homo sapiens 28-33 15498831-8 2005 Reincorporation of in vitro transcribed/translated PBR, but not PBR missing the cholesterol-binding domain, into MA-10 mitochondria rescued the ability of the mitochondria to form steroids and the ability of the mitochondria to respond to StAR and Tom/StAR proteins. Steroids 180-188 translocator protein Homo sapiens 51-54 15695463-2 2005 Regulation of seed storage protein genes At2S3 and CRC by ABI3 and FUS3 was investigated using transgenic plants in which ABI3 and FUS3 could be ectopically induced by steroid hormones. Steroids 168-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 67-71 15695463-2 2005 Regulation of seed storage protein genes At2S3 and CRC by ABI3 and FUS3 was investigated using transgenic plants in which ABI3 and FUS3 could be ectopically induced by steroid hormones. Steroids 168-184 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 131-135 15964615-2 2005 The present study aimed to investigate distribution patterns, staining intensity and sex steroid-mediated regulation of integrin alpha5 (CD49e), integrin beta4 (CD49f) expression and their ligands fibronectin and laminin during decidualization. Steroids 89-96 integrin subunit alpha 6 Homo sapiens 161-166 15610450-2 2005 In the present study, we evaluated the usefulness of stool DAF as a marker for monitoring disease activity in patients with steroid-resistant active UC being treated with leukocyte apheresis performed with a centrifugal cell separator. Steroids 124-131 CD55 molecule (Cromer blood group) Homo sapiens 59-62 15664414-1 2005 This study was to investigate the expression of Cdk inhibitors p27kip1 and p57kip2 during the development of mouse placenta and during the steroid-treated culture of human choriocarcinoma JEG-3 cells. Steroids 139-146 cyclin-dependent kinase inhibitor 1B Mus musculus 63-70 15598270-4 2005 METHODS: Life-supporting hDAF-transgenic kidney transplantation was performed in cynomolgus monkeys, using cyclophosphamide induction, and maintenance immunosuppression with cyclosporin A, mycophenolate sodium, and tapering steroids. Steroids 224-232 CD55 molecule (Cromer blood group) Homo sapiens 25-29 15650246-2 2004 In the present work, we report studies on sex steroid regulation of GJIC and proliferative activity in both nontumoral (Chang liver, CL) and malignant (HepG2, Huh7) human liver cells. Steroids 46-53 MIR7-3 host gene Homo sapiens 159-163 15677432-6 2004 Neuroactive steroids, such as DHEAS, and other sex hormones, including their synthetic derivatives, may have an adjunctive role in reversing or slowing the progression of negative symptoms. Steroids 12-20 sulfotransferase family 2A member 1 Homo sapiens 30-35 15838100-3 2004 The key discovery that set the scientific tone for the lab over the ensuing few decades began with the discovery that steroid hormones induced the nuclear production of specific mRNAs for ovalbumin and avidin in the chick oviduct. Steroids 118-134 ovalbumin (SERPINB14) Gallus gallus 188-197 15569155-3 2004 In the present study, we revealed that the adenovirus-mediated forced expression of SF-1 can transform cultured primary long-term cultured bone marrow cells into steroidogenic cells, showing the de novo synthesis of multiple steroid hormones in response to adrenocorticotropic hormone (ACTH). Steroids 225-241 splicing factor 1 Homo sapiens 84-88 15579739-1 2004 Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. Steroids 183-191 splicing factor 1 Homo sapiens 0-28 15458792-0 2004 Impact of androgenic/antiandrogenic compounds (AAC) on human sex steroid metabolizing key enzymes. Steroids 65-72 glycine-N-acyltransferase Homo sapiens 10-51 15458797-5 2004 Organic chemicals with a certain structural relationship to steroid hormones often induce a tissue- or cell-specific variety of responses distinct from estrogenic responses and this may involve ERR1 and AhR. Steroids 60-76 aryl hydrocarbon receptor Rattus norvegicus 203-206 15717807-1 2004 UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive. Steroids 109-124 sulfotransferase family 2A member 1 Homo sapiens 158-163 15530646-0 2004 Sex steroids reduce DNaseI accessibility of androgen receptor promoter in adult male mice brain. Steroids 4-12 deoxyribonuclease I Mus musculus 20-26 15530646-0 2004 Sex steroids reduce DNaseI accessibility of androgen receptor promoter in adult male mice brain. Steroids 4-12 androgen receptor Mus musculus 44-61 15530646-1 2004 We have previously reported that androgen receptor (AR) expression is inversely correlated to its promoter methylation and is regulated by sex steroids. Steroids 143-151 androgen receptor Mus musculus 33-50 15530646-1 2004 We have previously reported that androgen receptor (AR) expression is inversely correlated to its promoter methylation and is regulated by sex steroids. Steroids 143-151 androgen receptor Mus musculus 52-54 15530646-2 2004 As chromatin structure plays an important role in transcriptional regulation, the effect of sex steroids on DNaseI accessibility of chromatin of AR promoter was examined in the brain cortex of adult and old mice of both sexes. Steroids 96-104 deoxyribonuclease I Mus musculus 108-114 15530646-2 2004 As chromatin structure plays an important role in transcriptional regulation, the effect of sex steroids on DNaseI accessibility of chromatin of AR promoter was examined in the brain cortex of adult and old mice of both sexes. Steroids 96-104 androgen receptor Mus musculus 145-147 15591664-4 2004 In summary, this involves antenatal use of steroids if CDH antenatally diagnosed, sedation and muscle relaxation following tracheal intubation, administration of surfactant, gentle ventilation with permissive hypercapnia, trial of nitric oxide, preoperative ECMO for those infants failing therapy and delayed repair of the CDH. Steroids 43-51 choline dehydrogenase Homo sapiens 55-58 15334653-13 2004 In summary, treatment of BSC cultures with either E(2) or trenbolone increased IGF-I mRNA level and proliferation rate, thus, establishing that these steroids have direct anabolic effects on cells present in the BSC culture. Steroids 150-158 IGFI Bos taurus 79-84 15528992-8 2004 These results suggest that C. intestinalis 17beta-HSD is equivalent to the enzyme of vertebrate Leydig cells and that 17beta-HSD could be a phylogenetic marker for organisms producing steroids. Steroids 184-192 very-long-chain 3-oxoacyl-CoA reductase Ciona intestinalis 118-128 15352999-15 2004 CONCLUSIONS: Results suggest that despite an acute suppression of circulating NEFA concentrations during pregnancy, the associated steroids and hormones of pregnancy and possibly NEFA metabolism, may act to maintain a reduced insulin output, thereby sparing glucose for non-insulin dependent placental uptake and ultimately, fetal requirements. Steroids 131-139 LOC105613195 Ovis aries 226-233 15627884-9 2004 The steroid hormone receptor-positive breast cancer cell line BT-474 was used to examine the effect of different steroids on the expression levels of KLK5-SV2. Steroids 113-121 synaptic vesicle glycoprotein 2A Homo sapiens 155-158 15333129-1 2004 BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. Steroids 145-152 nuclear receptor subfamily 1 group I member 3 Homo sapiens 16-48 15333129-1 2004 BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. Steroids 145-152 nuclear receptor subfamily 1 group I member 3 Homo sapiens 50-53 15333129-1 2004 BACKGROUND: The constitutive androstane receptor (CAR, NR1I3) plays a key role in the transcriptional activation of genes that encode xenobiotic/steroid and drug metabolizing enzymes. Steroids 145-152 nuclear receptor subfamily 1 group I member 3 Homo sapiens 55-60 15294880-4 2004 In males and females, the transcriptional tone of the genes encoding alphaGSU and LHbeta reflects dynamic integration of a positive signal provided by GnRH from hypothalamic neurons and negative signals emanating from gonadal steroids. Steroids 226-234 luteinizing hormone subunit beta Homo sapiens 82-88 15291757-1 2004 Human 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is a key steroidogenic enzyme that catalyzes the first step in the conversion of circulating dehydroepiandrosterone (DHEA), pregnenolone or 17alpha-hydroxypregenolone to produce the appropriate, active steroid hormone(s): estradiol, testosterone, progesterone, aldosterone or cortisol respectively. Steroids 265-280 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 6-50 15291757-1 2004 Human 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD) is a key steroidogenic enzyme that catalyzes the first step in the conversion of circulating dehydroepiandrosterone (DHEA), pregnenolone or 17alpha-hydroxypregenolone to produce the appropriate, active steroid hormone(s): estradiol, testosterone, progesterone, aldosterone or cortisol respectively. Steroids 265-280 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 52-61 15291757-3 2004 Our three-dimensional homology model of 3beta-HSD shows that Tyr154 and Lys158 are oriented near the 3beta-hydroxyl group of the bound substrate steroid, and predicts that Ser123 or Ser124 completes a Tyr-Lys-Ser catalytic triad that operates in many other dehydrogenases. Steroids 145-152 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 40-49 15291757-12 2004 A role for Ser124 in the binding of the isomerase substrate, which is the 3beta-HSD product-steroid of the bifunctional enzyme protein, is also suggested. Steroids 92-99 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 74-83 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 progesterone receptor Mus musculus 51-53 15329476-12 2004 E2 stimulated the expression levels of ERalpha and PR mRNAs and P4 inhibited the expression of these transcripts at an early time point (12 h) and increased them at 24 and 48 h, while co-treatments with both steroids increased transcripts of ERalpha and PR at 24 h. In conclusion, P4 and PR may be dominant factors in the regulation of CaBP-9k. Steroids 208-216 progesterone receptor Mus musculus 254-256 15178021-1 2004 Constitutive androstane receptor (CAR) plays a key role in the transcriptional regulation of CYP2B, 2C and 3A genes in response to phenobarbital, ortho-chlorine substituted polychlorinated biphenyls (PCBs) and sex steroids in rodents and human. Steroids 214-222 nuclear receptor subfamily 1 group I member 3 Homo sapiens 0-32 15178021-1 2004 Constitutive androstane receptor (CAR) plays a key role in the transcriptional regulation of CYP2B, 2C and 3A genes in response to phenobarbital, ortho-chlorine substituted polychlorinated biphenyls (PCBs) and sex steroids in rodents and human. Steroids 214-222 nuclear receptor subfamily 1 group I member 3 Homo sapiens 34-37 15212846-1 2004 Androgen receptor (AR) is expressed in different tissues including the brain and is under regulation by sex steroid hormones. Steroids 108-115 androgen receptor Mus musculus 0-17 15212846-1 2004 Androgen receptor (AR) is expressed in different tissues including the brain and is under regulation by sex steroid hormones. Steroids 108-115 androgen receptor Mus musculus 19-21 15288775-5 2004 PKC activation initiates a signaling cascade that results in activation of the ERK1/2 family of mitogen activated protein kinases (MAPK), providing an alternate method for the steroids to modulate gene expression other than by traditional steroid hormone receptor-mediated pathways. Steroids 176-184 protein kinase C, alpha Rattus norvegicus 0-3 15241363-0 2004 Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. Steroids 85-93 negative elongation factor complex member C/D Homo sapiens 24-27 15241363-12 2004 CONCLUSION: These data suggest that beta2-agonists in combination with low doses of steroids can suppress T-cell proliferation and TH1 cytokine production from healthy individuals, but suppression of T cells with a combination of FP and salmeterol in asthmatic patients requires inhibition of phosphodiesterases. Steroids 84-92 negative elongation factor complex member C/D Homo sapiens 131-134 15272850-4 2004 The method provides very predictive models for the CBG activity of the benchmark steroid series, tinctorial properties of the heterocyclic azo dyes and anti-HIV activity of the HEPT series. Steroids 81-88 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 51-54 15615187-9 2004 On the other hand, SAA rejection in operation, acute allograft rejection and infection is present in spite of cyclosporine A and steroids therapy. Steroids 129-137 serum amyloid A1 cluster Homo sapiens 19-22 15094777-1 2004 Overexpression of the lipogenic enzyme fatty acid synthase (FAS) is a common molecular feature in subsets of sex-steroid-related tumors including endometrium and breast carcinomas that are associated with poor prognosis. Steroids 113-120 fatty acid synthase Homo sapiens 39-58 15094777-1 2004 Overexpression of the lipogenic enzyme fatty acid synthase (FAS) is a common molecular feature in subsets of sex-steroid-related tumors including endometrium and breast carcinomas that are associated with poor prognosis. Steroids 113-120 fatty acid synthase Homo sapiens 60-63 15153534-0 2004 CD56+ cells induce steroid resistance in B cells exposed to IL-15. Steroids 19-26 interleukin 15 Homo sapiens 60-65 15215507-1 2004 A key element in the regulation of mammalian steroid biosynthesis is the 18 kDa peripheral-type benzodiazepine receptor (PBR), which mediates mitochondrial cholesterol import. Steroids 45-52 translocator protein Homo sapiens 80-119 15215507-1 2004 A key element in the regulation of mammalian steroid biosynthesis is the 18 kDa peripheral-type benzodiazepine receptor (PBR), which mediates mitochondrial cholesterol import. Steroids 45-52 translocator protein Homo sapiens 121-124 15215507-8 2004 These results suggest that the PBR like protein is involved in steroid import and is directing protoporphyrinogen IX to the mitochondrial site of protoheme formation. Steroids 63-70 translocator protein Homo sapiens 31-34 15150408-0 2004 A balance between the diap1 death inhibitor and reaper and hid death inducers controls steroid-triggered cell death in Drosophila. Steroids 87-94 Death-associated inhibitor of apoptosis 1 Drosophila melanogaster 22-27 15150408-5 2004 This study reveals functional interactions between rpr and hid in Drosophila cell death responses and provides evidence that the precise timing of larval tissue cell death during metamorphosis is achieved through a steroid-triggered shift in the balance between the Drosophila inhibitor of apoptosis 1 and the rpr and hid death activators. Steroids 215-222 Death-associated inhibitor of apoptosis 1 Drosophila melanogaster 266-301 15123423-1 2004 The aldo-keto reductase rabbit 20alpha-hydroxysteroid dehydrogenase (rb20alpha-HSD; AKR1C5) is less selective than other HSDs, since it exerts its activity both on androgens (C19 steroids) and progestins (C21 steroids). Steroids 179-187 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 31-67 15123423-1 2004 The aldo-keto reductase rabbit 20alpha-hydroxysteroid dehydrogenase (rb20alpha-HSD; AKR1C5) is less selective than other HSDs, since it exerts its activity both on androgens (C19 steroids) and progestins (C21 steroids). Steroids 179-187 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 84-90 15123423-1 2004 The aldo-keto reductase rabbit 20alpha-hydroxysteroid dehydrogenase (rb20alpha-HSD; AKR1C5) is less selective than other HSDs, since it exerts its activity both on androgens (C19 steroids) and progestins (C21 steroids). Steroids 209-217 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 31-67 15123423-1 2004 The aldo-keto reductase rabbit 20alpha-hydroxysteroid dehydrogenase (rb20alpha-HSD; AKR1C5) is less selective than other HSDs, since it exerts its activity both on androgens (C19 steroids) and progestins (C21 steroids). Steroids 209-217 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 84-90 15126568-2 2004 Sex steroids regulate endometrial HOXA10 expression, which in turn negatively regulates EMX2. Steroids 4-12 empty spiracles homeobox 2 Homo sapiens 88-92 15225770-1 2004 The role in skeletal metabolism of the steroid hormone Vitamin D and its nuclear receptor (VDR) is well known. Steroids 39-46 vitamin D receptor Homo sapiens 55-89 15225770-1 2004 The role in skeletal metabolism of the steroid hormone Vitamin D and its nuclear receptor (VDR) is well known. Steroids 39-46 vitamin D receptor Homo sapiens 91-94 14990987-3 2004 In this communication, we identify p52(Shc) as the mediator between tyrosine phosphorylation signaling and steroid signaling in steroid-responsive cell proliferation. Steroids 107-114 SHC adaptor protein 1 Homo sapiens 39-42 14990987-3 2004 In this communication, we identify p52(Shc) as the mediator between tyrosine phosphorylation signaling and steroid signaling in steroid-responsive cell proliferation. Steroids 128-135 SHC adaptor protein 1 Homo sapiens 39-42 15016791-1 2004 Functional overload and anabolic steroid administration induce signaling pathways that regulate skeletal muscle RhoA expression. Steroids 33-40 ras homolog family member A Rattus norvegicus 112-116 15072559-2 2004 It is now well documented that the expression of many genes required for steroid biosynthesis is dependent on the coordinated expression of the nuclear receptor steroidogenic factor-1 (SF-1). Steroids 73-80 splicing factor 1 Homo sapiens 144-189 15005734-2 2004 Increased plasma levels of IL-10 have been detected in patients under glucocorticoid (GC) therapy, indicating that steroids may exert their suppressive effect, in part, by increasing IL-10 production. Steroids 115-123 interleukin 10 Homo sapiens 27-32 15005734-2 2004 Increased plasma levels of IL-10 have been detected in patients under glucocorticoid (GC) therapy, indicating that steroids may exert their suppressive effect, in part, by increasing IL-10 production. Steroids 115-123 interleukin 10 Homo sapiens 183-188 15005734-3 2004 OBJECTIVES: The aim was to define possible mechanisms by which steroids up-regulate IL-10 production. Steroids 63-71 interleukin 10 Homo sapiens 84-89 15005734-12 2004 CONCLUSION: Our results support the fact that steroids up-regulate constitutive IL-10 production by selectively triggering activation signals on monocytes. Steroids 46-54 interleukin 10 Homo sapiens 80-85 15120419-1 2004 BACKGROUND: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) are the major steroid hormones secreted by the adrenal gland. Steroids 81-97 sulfotransferase family 2A member 1 Homo sapiens 60-65 14696093-3 2004 We describe the effect of steroid hormones on the protein level of p66(Shc) and growth stimulation in hormone-sensitive human prostate, testicular and breast cancer cells. Steroids 26-33 SHC adaptor protein 1 Homo sapiens 71-74 14696093-9 2004 The data collectively indicate that p66(Shc) protein levels correlate with steroid hormone-stimulated cell growth and prostate carcinogenesis. Steroids 75-90 SHC adaptor protein 1 Homo sapiens 40-43 15062545-9 2004 Furthermore, the pubertal increase in GnRH mRNA appears to occur via steroid feedback-independent mechanisms in the male Syrian hamster. Steroids 69-76 progonadoliberin-1 Mesocricetus auratus 38-42 15007912-4 2004 PEF exhibited significant improvements at 6 months and 1 year in patients treated with or without inhalational steroids, while serum ECP was improved significantly only in the patients on inhalational steroids. Steroids 201-209 ribonuclease A family member 3 Homo sapiens 133-136 14573603-0 2004 Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 64-103 14573603-0 2004 Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. Steroids 128-135 sulfotransferase family 2A member 1 Homo sapiens 105-112 14573603-1 2004 In steroid biosynthesis, human dehydroepiandrosterone sulfotransferase (DHEA-ST) in the adrenals has been reported to catalyze the transfer of the sulfonate group from 3"-phosphoadenosine-5"-phosphosulfate to dehydroepiandrosterone (DHEA). Steroids 3-10 sulfotransferase family 2A member 1 Homo sapiens 31-70 14573603-1 2004 In steroid biosynthesis, human dehydroepiandrosterone sulfotransferase (DHEA-ST) in the adrenals has been reported to catalyze the transfer of the sulfonate group from 3"-phosphoadenosine-5"-phosphosulfate to dehydroepiandrosterone (DHEA). Steroids 3-10 sulfotransferase family 2A member 1 Homo sapiens 72-79 14712052-4 2004 The steroid nucleus has a small twist, as shown by the C19-C10...C13-C18 (steroid numbering) torsion angle of -6.9 (3) degrees. Steroids 4-11 homeobox C13 Homo sapiens 65-68 14712052-4 2004 The steroid nucleus has a small twist, as shown by the C19-C10...C13-C18 (steroid numbering) torsion angle of -6.9 (3) degrees. Steroids 74-81 homeobox C13 Homo sapiens 65-68 15212190-4 2004 PEF exhibited significant improvements after 6 months and 1 year in patients treated with or without inhalational steroids, while serum ECP was improved significantly only in the patients on inhalational steroids. Steroids 204-212 ribonuclease A family member 3 Homo sapiens 136-139 15242338-3 2004 The hsp90-/hsp70-based chaperone machinery interacts with the unliganded glucocorticoid receptor to open the steroid-binding cleft to access by a steroid, and the machinery interacts in very dynamic fashion with the liganded, transformed receptor to facilitate its translocation along microtubular highways to the nucleus. Steroids 109-116 heat shock protein family A (Hsp70) member 4 Homo sapiens 11-16 15242338-3 2004 The hsp90-/hsp70-based chaperone machinery interacts with the unliganded glucocorticoid receptor to open the steroid-binding cleft to access by a steroid, and the machinery interacts in very dynamic fashion with the liganded, transformed receptor to facilitate its translocation along microtubular highways to the nucleus. Steroids 146-153 heat shock protein family A (Hsp70) member 4 Homo sapiens 11-16 15314251-3 2004 Pregnenolone, the main steroid synthesized from cholesterol in the nervous system (therefore, a neurosteroid), binds specifically with high affinity (> or = 40 nM) to microtubule-associated protein 2 (MAP2), a protein family involved in the assembly and stabilization of microtubules made from tubulin alpha and beta polymers, and in the bundling of several microtubules by MAP2 projection arms. Steroids 23-30 microtubule associated protein 2 Homo sapiens 167-199 15314251-3 2004 Pregnenolone, the main steroid synthesized from cholesterol in the nervous system (therefore, a neurosteroid), binds specifically with high affinity (> or = 40 nM) to microtubule-associated protein 2 (MAP2), a protein family involved in the assembly and stabilization of microtubules made from tubulin alpha and beta polymers, and in the bundling of several microtubules by MAP2 projection arms. Steroids 23-30 microtubule associated protein 2 Homo sapiens 201-205 15314251-4 2004 Pregnenolone binding increases MAP2-induced microtubule polymerization, when purified tubulin and MAP2 are coincubated in GTP containing buffer at 37 degrees C. Therefore, MAP2 can be considered as a receptor for a novel mechanism of steroid action. Steroids 234-241 microtubule associated protein 2 Homo sapiens 31-35 15314251-4 2004 Pregnenolone binding increases MAP2-induced microtubule polymerization, when purified tubulin and MAP2 are coincubated in GTP containing buffer at 37 degrees C. Therefore, MAP2 can be considered as a receptor for a novel mechanism of steroid action. Steroids 234-241 microtubule associated protein 2 Homo sapiens 98-102 15314251-4 2004 Pregnenolone binding increases MAP2-induced microtubule polymerization, when purified tubulin and MAP2 are coincubated in GTP containing buffer at 37 degrees C. Therefore, MAP2 can be considered as a receptor for a novel mechanism of steroid action. Steroids 234-241 microtubule associated protein 2 Homo sapiens 98-102 14643170-8 2004 The results suggest that the topical steroids fluticasone, budesonide and to a lesser extent beclomethasone may have beneficial effects on airway inflammation in asthma by reducing RANTES and IL-8-induced leukocyte infiltration into the airway wall. Steroids 37-45 C-C motif chemokine ligand 5 Homo sapiens 181-187 14715372-1 2004 22R-Hydroxycholesterol is an intermediate in the steroid biosynthesis pathway shown to exhibit a neuroprotective property against beta-amyloid (1-42) (Abeta) toxicity in rat PCl2 and human NT2N neuronal cells by binding and inactivating Abeta. Steroids 49-56 amyloid beta precursor protein Rattus norvegicus 151-156 14665668-4 2003 We demonstrate that a key enzyme for steroid hormone biosynthesis, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), is a target of p45 NF-E2, and rescues PPF of p45 NF-E2-deficient megakaryocytes. Steroids 37-52 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-101 14665668-4 2003 We demonstrate that a key enzyme for steroid hormone biosynthesis, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), is a target of p45 NF-E2, and rescues PPF of p45 NF-E2-deficient megakaryocytes. Steroids 37-52 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 103-112 14676970-6 2003 Steroid signaling in plants comprises the plasma membrane receptor kinases BRI1 and BAK1 and intracellular protein phosphorylations. Steroids 0-7 BCL2 antagonist/killer 1 Homo sapiens 84-88 14556075-2 2003 This study"s purpose was to determine if RhoA expression and activity in rat plantaris muscle was induced by functional overload with or without anabolic steroid administration. Steroids 154-161 ras homolog family member A Rattus norvegicus 41-45 14556075-11 2003 In conclusion, RhoA is an integrator of both mechanical and growth factor signaling whose expression and activity are increased by the combination of anabolic steroid and functional overload treatments in rat plantaris muscle. Steroids 159-166 ras homolog family member A Rattus norvegicus 15-19 14644820-28 2003 The major steroid produced by the fetal adrenal zone is sulfoconjugated dehydroepiandrosterone (DHEAS). Steroids 10-17 sulfotransferase family 2A member 1 Homo sapiens 96-101 14602803-1 2003 Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. Steroids 40-47 fibroblast growth factor 9 Homo sapiens 0-26 14602803-1 2003 Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. Steroids 40-47 fibroblast growth factor 9 Homo sapiens 28-33 12975815-2 2003 The neuropeptides galanin (GAL), cholecystokinin (CCK), and substance P (SP) are highly expressed in BSTp neurons and are differentially regulated by sex steroids. Steroids 154-162 cholecystokinin Rattus norvegicus 33-48 12975815-2 2003 The neuropeptides galanin (GAL), cholecystokinin (CCK), and substance P (SP) are highly expressed in BSTp neurons and are differentially regulated by sex steroids. Steroids 154-162 cholecystokinin Rattus norvegicus 50-53 14529265-9 2003 Our findings indicate that cooperativity in bile salt-I-BABP recognition is governed by the pattern of steroid B- and C-ring hydroxylation and not the presence or type of side-chain conjugation. Steroids 103-110 fatty acid binding protein 6 Homo sapiens 54-60 12890680-1 2003 Steroids regulate alternative splicing of rabbit RUSH/SMARCA3, an SWI/SNF-related transcription factor. Steroids 0-8 helicase-like transcription factor Oryctolagus cuniculus 49-53 12890680-1 2003 Steroids regulate alternative splicing of rabbit RUSH/SMARCA3, an SWI/SNF-related transcription factor. Steroids 0-8 helicase-like transcription factor Oryctolagus cuniculus 54-61 14517287-9 2003 This work indicates that although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis. Steroids 50-57 steroid receptor RNA activator 1 Homo sapiens 85-88 12807878-0 2003 Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft. Steroids 144-151 heat shock protein family A (Hsp70) member 4 Homo sapiens 69-74 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 174-181 heat shock protein family A (Hsp70) member 4 Homo sapiens 42-47 12807878-1 2003 A minimal system of five proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. Steroids 209-216 heat shock protein family A (Hsp70) member 4 Homo sapiens 42-47 12920167-10 2003 Furthermore, the high activity of UGT1A8 and 1A10 toward some of the substrates indicates that extrahepatic enzymes might play a role in the metabolism of anabolic androgenic steroids. Steroids 175-183 UDP glucuronosyltransferase family 1 member A8 Homo sapiens 34-40 12957662-0 2003 Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 100-107 translocator protein Homo sapiens 0-39 12957662-3 2003 PBR gene disruption in Leydig cells completely blocked cholesterol transport into mitochondria and steroid formation, while PBR expression in bacteria, devoid of endogenous PBR and cholesterol, induced cholesterol uptake and transport. Steroids 99-106 translocator protein Homo sapiens 0-3 12957662-8 2003 This suggests that the various polymeric states of PBR might be part of a cycle mediating cholesterol uptake and release into the mitochondria, with PBR functioning as a cholesterol exchanger against steroid product(s) arising from cytochrome P450 action. Steroids 200-207 translocator protein Homo sapiens 51-54 12957662-8 2003 This suggests that the various polymeric states of PBR might be part of a cycle mediating cholesterol uptake and release into the mitochondria, with PBR functioning as a cholesterol exchanger against steroid product(s) arising from cytochrome P450 action. Steroids 200-207 translocator protein Homo sapiens 149-152 12637261-10 2003 These data suggest a novel metabolic role for sPLA2: modification of HDL during the APR to promote increased adrenal uptake of HDL cholesteryl ester to serve as source for steroid hormone synthesis. Steroids 172-187 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 46-51 12882748-7 2003 He tested positive for anti-GAD antibodies and received treatment with immunoglobulins and steroids. Steroids 91-99 glutamate decarboxylase 1 Homo sapiens 28-31 12835383-7 2003 We show that WNT4 represses mesonephric endothelial and steroidogenic cell migration in the XX gonad, preventing the formation of a male-specific coelomic blood vessel and the production of steroids. Steroids 190-198 Wnt family member 4 Homo sapiens 13-17 12736396-9 2003 In conclusion, add-on treatment with montelukast can suppress sputum ECP in children with steroid-dependent asthma, while at the same time an improvement in quality of life items occurs. Steroids 90-97 ribonuclease A family member 3 Homo sapiens 69-72 12795679-0 2003 Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts. Steroids 82-90 CD55 molecule (Cromer blood group) Homo sapiens 142-146 12768545-1 2003 Steroid hormone biosynthesis in the adrenal cortex and gonads involves the coordinated transcription of the genes encoding the steroid hydroxylases, 3beta-hydroxysteroid dehydrogenase (3betaHSD), the steroidogenic acute regulatory protein (StAR), and adrenodoxin (Adx). Steroids 0-15 ferredoxin 1 Homo sapiens 251-262 12768545-1 2003 Steroid hormone biosynthesis in the adrenal cortex and gonads involves the coordinated transcription of the genes encoding the steroid hydroxylases, 3beta-hydroxysteroid dehydrogenase (3betaHSD), the steroidogenic acute regulatory protein (StAR), and adrenodoxin (Adx). Steroids 0-15 ferredoxin 1 Homo sapiens 264-267 12774311-3 2003 To confirm the notion that sex steroids and dexamethasone influence brain edema through AQP4 regulation, we investigated the effects of 17beta-estradiol, testosterone, and dexamethasone on the expression of AQP4 in cultured astrocytes. Steroids 31-39 aquaporin 4 Homo sapiens 88-92 12774311-3 2003 To confirm the notion that sex steroids and dexamethasone influence brain edema through AQP4 regulation, we investigated the effects of 17beta-estradiol, testosterone, and dexamethasone on the expression of AQP4 in cultured astrocytes. Steroids 31-39 aquaporin 4 Homo sapiens 207-211 12756159-8 2003 Patients who received combined steroids had lower serum IL-6 and increased IL-10 at end-bypass (P<0.05), although differences were negligible by 24 hours. Steroids 31-39 interleukin 10 Homo sapiens 75-80 12773127-0 2003 Distribution and changes in amounts of the androgen receptor in the pig uterus during the estrous cycle, early pregnancy and after treatment with sex steroids. Steroids 150-158 androgen receptor Sus scrofa 43-60 12697717-19 2003 17 beta HSDXI could act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Steroids 65-72 hydroxysteroid 17-beta dehydrogenase 11 Homo sapiens 0-13 12523936-3 2003 Since MRP4, like MRP1-3, also mediates transport of a model steroid conjugate substrate, oestradiol 17-beta-D-glucuronide (E(2)17betaG), we tested whether MRP4 may be involved in the transport of steroid and bile acid conjugates. Steroids 196-203 ATP binding cassette subfamily C member 4 Homo sapiens 6-10 12523936-6 2003 Furthermore, we found that MRP4 transports dehydroepiandrosterone 3-sulphate (DHEAS), the most abundant circulating steroid in humans, which is made in the adrenal gland. Steroids 116-123 ATP binding cassette subfamily C member 4 Homo sapiens 27-31 12523936-6 2003 Furthermore, we found that MRP4 transports dehydroepiandrosterone 3-sulphate (DHEAS), the most abundant circulating steroid in humans, which is made in the adrenal gland. Steroids 116-123 sulfotransferase family 2A member 1 Homo sapiens 78-83 12523936-11 2003 Our findings suggest a physiological role for MRP1 and MRP4 in DHEAS transport and an involvement of MRP4 in transport of conjugated steroids and bile acids. Steroids 133-141 ATP binding cassette subfamily C member 4 Homo sapiens 101-105 12642469-5 2003 On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction. Steroids 289-297 sulfotransferase family 2A member 1 Homo sapiens 221-227 12749421-11 2003 CONCLUSION(S): Endogenous and exogenous sex-steroid hormones, in the form of a combined oral contraceptive or levonorgestrel intrauterine system, influence gene transcription of secretory leukocyte protease inhibitor, beta-defensin 1, beta-defensin 2, and granulysin in the endometrium. Steroids 44-51 defensin beta 4B Homo sapiens 235-250 12732855-5 2003 RESULTS: Delivery room intubations, days on mechanical ventilation and use of postnatal steroids decreased (p<0.001) in period 2, while mean days on CPAP, number of babies on CPAP at 24 hours (p<0.001) and mean weight at 36 weeks corrected gestation also increased (p<0.05) after introduction of early bubble CPAP. Steroids 88-96 period circadian regulator 2 Homo sapiens 123-131 12559723-0 2003 Relationship between intrafollicular concentrations of parathyroid hormone-related peptide (PTHrP) and steroid hormones in oestrogenic and non-oestrogenic ovarian follicles in the mare. Steroids 103-119 parathyroid hormone like hormone Equus caballus 55-90 12559723-0 2003 Relationship between intrafollicular concentrations of parathyroid hormone-related peptide (PTHrP) and steroid hormones in oestrogenic and non-oestrogenic ovarian follicles in the mare. Steroids 103-119 parathyroid hormone like hormone Equus caballus 92-97 12620484-0 2003 Effect of female sex steroids on human endometrial CD16neg CD56bright natural killer cells. Steroids 21-29 Fc gamma receptor IIIa Homo sapiens 51-55 12620484-1 2003 OBJECTIVE: To clarify whether female sex steroids directly affect the bioactivity of the human endometrial CD16neg CD56bright natural killer (NK) cells. Steroids 41-49 Fc gamma receptor IIIa Homo sapiens 107-111 12611597-1 2003 It has been suggested that endometrial angiogenesis in response to the sex steroids oestrogen and progesterone is mediated at a local level via compounds such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), acting through their respective tyrosine kinase receptors. Steroids 75-83 vascular endothelial growth factor A Mus musculus 162-196 12697154-4 2003 After 4 weeks of prednisolone treatment, patients with steroid-resistant NS (SRNS) presented a higher serum TNF-beta level than that before treatment (p=0.008). Steroids 55-62 lymphotoxin alpha Homo sapiens 108-116 12552091-13 2003 This paper provides evidence for regulatory interaction between a sex steroid and the GHJAKSTAT pathway, in which SOCS-2 plays a central mechanistic role. Steroids 70-77 suppressor of cytokine signaling 2 Homo sapiens 114-120 12538622-8 2003 The action of the steroid on the fetal brain was also demonstrated as dose-related increases in the abundance of Fos in fetal cerebellum. Steroids 18-25 protein c-Fos Ovis aries 113-116 12532375-7 2003 The ring design, with respect to the position of the steroid layer(s), affected the release of P and E2 from the vaginal rings. Steroids 53-60 cystatin 12, pseudogene Homo sapiens 95-103 12711014-11 2003 Evidence is provided for a varying expression of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo, respectively under steroid supplementation in vitro. Steroids 145-152 estrogen receptor 2 Bos taurus 58-64 12711014-11 2003 Evidence is provided for a varying expression of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo, respectively under steroid supplementation in vitro. Steroids 145-152 progesterone receptor Bos taurus 69-71 12735108-9 2003 A potential decrease in bile acid and steroid biosynthesis was indicated by the decreased expression of Cyp7b1 and Hsd3b4, respectively. Steroids 38-45 cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus 104-110 12544632-8 2003 A significantly higher number of c-fos expressing neurons were observed in the periventricular region of the steroid-2 than the control and vehicle groups, indicating enhanced neuronal activity after nandrolone decanoate treatment. Steroids 109-116 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 33-38 12890523-1 2003 The enzyme 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) is involved in the generation of neuroactive steroids through ring-A-reduction of hormonal precursors. Steroids 107-115 aldo-keto reductase family 1, member C14 Rattus norvegicus 11-47 12890523-1 2003 The enzyme 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) is involved in the generation of neuroactive steroids through ring-A-reduction of hormonal precursors. Steroids 107-115 aldo-keto reductase family 1, member C14 Rattus norvegicus 49-60 12890523-5 2003 Adrenalectomy and gonadectomy, and supplementation with individual steroid hormones influenced 3 alpha-HSD expression in a gender-specific mode. Steroids 67-83 aldo-keto reductase family 1, member C14 Rattus norvegicus 95-106 12890523-9 2003 These data suggest that (i) transient increase of neurosteroid biosynthesis may contribute to stress hyporesponsiveness during early infancy; (ii) gonadal steroids regulate 3 alpha-HSD expression in the hippocampus in a sex-specific mode; (iii) physiological sex steroid secretions in females may mask behavioral consequences of adverse early life events, and (iv) concomitant treatment with the neurosteroid THP counteracts behavioral and endocrine dysregulation induced by neonatal stress in both genders. Steroids 155-163 aldo-keto reductase family 1, member C14 Rattus norvegicus 173-184 12890523-9 2003 These data suggest that (i) transient increase of neurosteroid biosynthesis may contribute to stress hyporesponsiveness during early infancy; (ii) gonadal steroids regulate 3 alpha-HSD expression in the hippocampus in a sex-specific mode; (iii) physiological sex steroid secretions in females may mask behavioral consequences of adverse early life events, and (iv) concomitant treatment with the neurosteroid THP counteracts behavioral and endocrine dysregulation induced by neonatal stress in both genders. Steroids 55-62 aldo-keto reductase family 1, member C14 Rattus norvegicus 173-184 12650704-6 2002 In human breast cancer cells, we have identified a variety of agents, including steroid hormones, phytoestrogens and growth factors, that up-regulate VDR expression and enhance sensitivity to 1,25(OH)(2)D(3)-mediated growth inhibition. Steroids 80-96 vitamin D receptor Homo sapiens 150-153 12441185-10 2002 Replacement of sex steroids to GDX rats restored the normal level of sex steroids, AR and ER. Steroids 19-27 androgen receptor Rattus norvegicus 83-85 12239109-3 2002 The aims of the present study were to determine whether the NE and epinephrine neurons continue to express estrogen receptor (ER)-alpha in middle-aged rats; temporal expression of ER-alpha and cFos changes with age during the steroid-induced surge; and tyrosine hydroxylase (TH), dopamine-beta-hydroxylase (DBH), and phenylethanol-N-methyltransferase mRNA content in catecholaminergic neurons of the brain stem changes during the surge with age. Steroids 226-233 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 193-197 12368374-10 2002 CONCLUSION: 99mTc-annexin V can detect collagen-induced immune arthritis and its response to steroid therapy before joint destruction. Steroids 93-100 annexin A5 Mus musculus 18-27 12411099-7 2002 It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD68, MCP-1, and MIP-1alpha, but had no effect on MIP-1beta in glomeruli with cellular crescents of patients with LN-CGN. Steroids 18-25 CD68 molecule Homo sapiens 99-103 12171960-10 2002 In vitro studies indicated a direct effect of steroid treatment on STAT1 activation. Steroids 46-53 signal transducer and activator of transcription 1 Homo sapiens 67-72 12202413-2 2002 Cell adhesion molecules (CAMs) involved in leukocyte-endothelial interactions, e.g. intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, are regulated by sex steroids when expressed by cultured endothelium, while uterine and ovarian CAM expression appears to be cyclically or gonadotrophin-regulated. Steroids 208-216 intercellular adhesion molecule 1 Homo sapiens 84-117 12202413-2 2002 Cell adhesion molecules (CAMs) involved in leukocyte-endothelial interactions, e.g. intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, are regulated by sex steroids when expressed by cultured endothelium, while uterine and ovarian CAM expression appears to be cyclically or gonadotrophin-regulated. Steroids 208-216 intercellular adhesion molecule 1 Homo sapiens 119-125 12226529-2 2002 Arabidopsis CYP90B1/DWF4 and CYP90A1/CPD are responsible for respective C-22 and C-23 hydroxylation of the steroid side chain and CYP85A1 catalyzes C-6 oxidation of 6-deoxo intermediates, whereas the functions of CYP90C1/ROT3, CYP90D1, and CYP85A2 are still unknown. Steroids 107-114 Cytochrome P450 superfamily protein Arabidopsis thaliana 12-19 12226529-2 2002 Arabidopsis CYP90B1/DWF4 and CYP90A1/CPD are responsible for respective C-22 and C-23 hydroxylation of the steroid side chain and CYP85A1 catalyzes C-6 oxidation of 6-deoxo intermediates, whereas the functions of CYP90C1/ROT3, CYP90D1, and CYP85A2 are still unknown. Steroids 107-114 Cytochrome P450 superfamily protein Arabidopsis thaliana 20-24 12226529-2 2002 Arabidopsis CYP90B1/DWF4 and CYP90A1/CPD are responsible for respective C-22 and C-23 hydroxylation of the steroid side chain and CYP85A1 catalyzes C-6 oxidation of 6-deoxo intermediates, whereas the functions of CYP90C1/ROT3, CYP90D1, and CYP85A2 are still unknown. Steroids 107-114 cytochrome P450, family 90, subfamily D, polypeptide 1 Arabidopsis thaliana 227-234 12124798-2 2002 We examined previously the steroid hormone regulation of 2 known androgen-regulated kallikreins, KLK3 (encoding PSA) and KLK2 (encoding human kallikrein 2 or hK2) in BT-474, T-47D, ZR75-1, MCF-7, MFM-223 and BT-20 human breast cancer cells and found that they were differentially regulated, with the cells showing variable responses to androgen. Steroids 27-42 kallikrein related peptidase 2 Homo sapiens 121-125 12153748-2 2002 DESIGN: Auxological studies in a 20-year-old Japanese female with 45,X[28]/46,X,psu idic(X)(q28)[72], gonadal estrogen deficiency, and SHOX duplication on the idic(X) chromosome, who received sex steroid replacement therapy from 16 years 8 months of age. Steroids 196-203 short stature homeobox Homo sapiens 135-139 12428206-1 2002 The 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)isomerase (3beta-HSD) isoenzymes are responsible for the oxidation and isomerization of Delta(5)-3beta-hydroxysteroid precursors into Delta(4)-ketosteroids, thus catalyzing an essential step in the formation of all classes of active steroid hormones. Steroids 17-24 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-76 12428206-2 2002 The 3beta-HSD gene family should have evolved to facilitate differential patterns of tissue- and cell-specific expression and regulation involving multiple signal transduction pathways, which are activated by several growth factors, steroids, and cytokines. Steroids 233-241 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 4-13 12188026-1 2002 The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid. Steroids 192-208 vitamin D receptor Homo sapiens 113-131 12188026-1 2002 The active form of vitamin D, 1,25-Dihydroxyvitamin D3 [l,25(OH)2D3], is a secosteroid hormone that binds to the vitamin D receptor (VDR), a member of the superfamily of nuclear receptors for steroid hormones, thyroid hormone, and retinoic acid. Steroids 192-208 vitamin D receptor Homo sapiens 133-136 11985524-4 2002 Median IL-10 levels increased throughout the steroid treatment period and were associated strongly with TNF-alpha levels. Steroids 45-52 interleukin 10 Homo sapiens 7-12 12127038-4 2002 Given the important role that steroid hormones play in bone cell development and in the maintenance of normal bone architecture, polymorphisms at receptor of the steroid/thyroid hormone receptor superfamily, such as estrogen receptor alpha (ERalpha) and Vitamin D receptor (VDR) have been thoroughly investigated in the last years and appeared to represent important candidate genes. Steroids 30-46 vitamin D receptor Homo sapiens 254-272 11850104-4 2002 The PBR is widely expressed throughout the body, with high densities found in steroid-producing tissues. Steroids 78-85 translocator protein Homo sapiens 4-7 12034893-3 2002 We used a transgenic Arabidopsis line carrying the bacterial avirulence gene avrRpm1 under the control of a steroid-inducible promoter to select for mutations in genes required for RPM1-mediated recognition and signal transduction. Steroids 108-115 NB-ARC domain-containing disease resistance protein Arabidopsis thaliana 181-185 11948967-5 2002 Like KLK2 and KLK3, the KLK5 gene is regulated by steroid hormones in the BT-474 breast cancer cell line. Steroids 50-66 kallikrein related peptidase 2 Homo sapiens 5-9 12108525-3 2002 We investigated the effects of ovarian steroids on the expression of p21, DNA synthesis, and mitosis in the uterus. Steroids 39-47 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 69-72 11963828-0 2002 Regulation of glutamic acid decarboxylase 65 and 67 gene expression by ovarian steroids: identification of two functionally distinct populations of GABA neurones in the preoptic area. Steroids 79-87 glutamate decarboxylase 2 Rattus norvegicus 14-44 11832334-0 2002 sgk: an essential convergence point for peptide and steroid hormone regulation of ENaC-mediated Na+ transport. Steroids 52-59 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-3 11832334-4 2002 The D222A sgk mutant, which lacks kinase activity, functions as a dominant-negative mutant inhibiting basal as well as peptide- and steroid hormone-stimulated Na+ transport. Steroids 132-147 serum/glucocorticoid regulated kinase 1 Homo sapiens 10-13 12025522-6 2002 Steroids suppressed the production of IL-18 and other secondary cytokines in LPS/IL-2-stimulated PBMCs, in a concentration- and time-dependent manner, although inhibition was incomplete even at high concentrations. Steroids 0-8 interleukin 18 Homo sapiens 38-43 12025522-7 2002 Effects of steroid treatment on expression of membrane-bound LPS receptor antigen (mCD14) and intercellular adhesion molecule-1 (ICAM-1) in PBMCs were studied by flow cytometric analysis. Steroids 11-18 intercellular adhesion molecule 1 Homo sapiens 94-127 12025522-7 2002 Effects of steroid treatment on expression of membrane-bound LPS receptor antigen (mCD14) and intercellular adhesion molecule-1 (ICAM-1) in PBMCs were studied by flow cytometric analysis. Steroids 11-18 intercellular adhesion molecule 1 Homo sapiens 129-135 11882014-2 2002 In this study, the effect of diets designed to increase circulating insulin and insulin-like growth factor I (IGF-I) concentrations on steroid production by granulosa cells in vitro was examined to analyse the mechanisms through which these changes occur. Steroids 135-142 IGFI Bos taurus 110-115 11969366-5 2002 Human EG-VEGF is expressed by steroid producing cells in the adrenal gland, placenta, testis and ovary, and is a mitogen for endothelial cells derived from these microvascular beds. Steroids 30-37 prokineticin 1 Homo sapiens 6-13 11850122-0 2002 Steroid hormonal regulation of proliferative, p53 tumor suppressor, and apoptotic responses of sheep ovarian surface epithelial cells. Steroids 0-7 cellular tumor antigen p53 Ovis aries 46-49 11835121-2 2002 A considerable structural similarity exists between AR and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) (both belonging to aldo-keto reductase superfamily); 3alpha-HSD forms 5alpha-reduced-3alpha-hydroxylated steroids, possibly possessing neurotrophic functions. Steroids 213-221 aldo-keto reductase family 1, member C14 Rattus norvegicus 52-94 11835121-2 2002 A considerable structural similarity exists between AR and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) (both belonging to aldo-keto reductase superfamily); 3alpha-HSD forms 5alpha-reduced-3alpha-hydroxylated steroids, possibly possessing neurotrophic functions. Steroids 213-221 aldo-keto reductase family 1, member C14 Rattus norvegicus 96-106 11835121-2 2002 A considerable structural similarity exists between AR and 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) (both belonging to aldo-keto reductase superfamily); 3alpha-HSD forms 5alpha-reduced-3alpha-hydroxylated steroids, possibly possessing neurotrophic functions. Steroids 213-221 aldo-keto reductase family 1, member C14 Rattus norvegicus 161-171 11835121-3 2002 Aim of these experiments was to test "in vitro" in rat sciatic nerves, whether glucose concentrations in the diabetic range might affect the capacity of 3alpha-HSD to transform dihydroprogesterone (DHP) into tetrahydroprogesterone (THP), a steroid proved to possess neurotrophic effects. Steroids 240-247 aldo-keto reductase family 1, member C14 Rattus norvegicus 153-163 12815801-11 2002 CONCLUSIONS: Oral antihistamine in combination with topical steroids leads to several significant changes in the immune parameters (IgE levels, CD4:CD8 and proliferation indexes) which may explain its high effectiveness in majority of patients with AD. Steroids 60-68 CD8a molecule Homo sapiens 148-151 11752199-5 2002 Including CYP2B10, CYP3A11, and NADPH-CYP reductase, CAR regulated a group of the PB-induced drug/steroid-metabolizing enzymes. Steroids 98-105 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 19-26 12119317-4 2002 After 1 month of steroid therapy, there was a significant improvement in the WCST, digit span backward and alphabet span tests, whereas PCL remained severely impaired. Steroids 17-24 PHD finger protein 1 Homo sapiens 136-139 11990382-1 2002 SULT2A1 catalyzes the sulfate conjugation of dehydroepiandrosterone (DHEA) as well as other steroids. Steroids 92-100 sulfotransferase family 2A member 1 Homo sapiens 0-7 11739460-1 2001 The steroid cell enzyme 3 beta hydroxysteroid dehydrogenase (3 beta HSD) has been identified as a target of steroid cell autoantibodies, and autoantibodies to this enzyme are present in patients with premature ovarian failure and patients with autoimmune polyendocrine syndrome 1. Steroids 4-11 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 61-71 11597463-4 2001 In the second type, both pharmacophore groups were connected to C-3 of the steroid through an alkenyl chain containing an amide moiety. Steroids 75-82 complement C3 Homo sapiens 64-67 11744100-2 2001 Utilizing different in vivo (aged and adult male rats) and in vitro (Schwann cell cultures) experimental models, we have observed that neuroactive steroids are able to stimulate the mRNA levels of Po and PMP22. Steroids 147-155 peripheral myelin protein 22 Rattus norvegicus 204-209 11744100-3 2001 The effects of these neuroactive steroids, which are able to interact with classical (progesterone receptor, PR, and androgen receptor, AR) and non-classical (GABA(A) receptor) steroid receptors is further supported by our demonstration in sciatic nerve and/or Schwann cells of the presence of these receptors. Steroids 33-41 androgen receptor Rattus norvegicus 86-134 11606451-13 2001 These data suggest that PPAR gamma is involved in follicular development, has a negative influence on the luteinization of granulosa cells, and/or regulates the periovulatory shift in steroid production. Steroids 184-191 peroxisome proliferator-activated receptor gamma Rattus norvegicus 24-34 11690703-0 2001 Rapid changes in alcoholic hepatitis histology under steroids: correlation with soluble intercellular adhesion molecule-1 in hepatic venous blood. Steroids 53-61 intercellular adhesion molecule 1 Homo sapiens 88-121 11690703-12 2001 CONCLUSIONS: In severe AH under steroids, the short term histological improvement was associated with a decrease in circulating TNFalpha, a decrease in ICAM-1 expression, and correlated to hepatic vein sICAM-1 changes. Steroids 32-40 intercellular adhesion molecule 1 Homo sapiens 152-158 11457860-6 2001 Blockade of the IGFIR with the alphaIR3 anti-IGFR antibody could partially inhibit the growth of the estrogen-deprived cells, suggesting that up-regulation of IGFR in these cells may contribute to the mechanism of adaptation to growth in steroid-deprived conditions which results in progression to estrogen independence of cell growth. Steroids 238-245 insulin like growth factor 1 receptor Homo sapiens 16-21 11457860-6 2001 Blockade of the IGFIR with the alphaIR3 anti-IGFR antibody could partially inhibit the growth of the estrogen-deprived cells, suggesting that up-regulation of IGFR in these cells may contribute to the mechanism of adaptation to growth in steroid-deprived conditions which results in progression to estrogen independence of cell growth. Steroids 238-245 insulin like growth factor 1 receptor Homo sapiens 45-49 11457860-6 2001 Blockade of the IGFIR with the alphaIR3 anti-IGFR antibody could partially inhibit the growth of the estrogen-deprived cells, suggesting that up-regulation of IGFR in these cells may contribute to the mechanism of adaptation to growth in steroid-deprived conditions which results in progression to estrogen independence of cell growth. Steroids 238-245 insulin like growth factor 1 receptor Homo sapiens 159-163 11694456-4 2001 We therefore studied expression of the steroid-sensitive extraneuronal monoamine transporter (EMT) and steroid sensitivity of NE uptake in human bronchial artery and rabbit aorta (as a substitute for the limited supply of human bronchial artery). Steroids 39-46 solute carrier family 22 member 3 Homo sapiens 57-92 11694456-4 2001 We therefore studied expression of the steroid-sensitive extraneuronal monoamine transporter (EMT) and steroid sensitivity of NE uptake in human bronchial artery and rabbit aorta (as a substitute for the limited supply of human bronchial artery). Steroids 39-46 solute carrier family 22 member 3 Homo sapiens 94-97 11694456-8 2001 These data show that NE uptake into bronchial arterial and rabbit aortic SMCs is sensitive to steroids, possibly mediated by EMT, and suggest a mechanism for GS-induced bronchial vasoconstriction. Steroids 94-102 solute carrier family 22 member 3 Homo sapiens 125-128 11591195-3 2001 OBJECTIVE: The aims were to identify and quantify the T cell regulatory cytokine IL-15 in induced sputum samples from asthmatic patients, in comparison with IL-13, and to relate the levels of these cytokines to treatment with inhaled steroids. Steroids 234-242 interleukin 15 Homo sapiens 81-86 11591195-7 2001 RESULTS: IL-15 levels were increased and IL-13 levels were decreased in sputum fluid from steroid-treated compared with non-steroid-treated asthmatics. Steroids 90-97 interleukin 15 Homo sapiens 9-14 11502894-7 2001 Other steroids of the pregnane class induced GSTA2 expression as expected for a PXR-dependent process. Steroids 6-14 glutathione S-transferase alpha 2 Rattus norvegicus 45-50 11528220-0 2001 Role of gonadal steroids in the corticotropin-releasing hormone and proopiomelanocortin gene expression response to Delta(9)-tetrahydrocannabinol in the hypothalamus of the rat. Steroids 16-24 proopiomelanocortin Rattus norvegicus 68-87 11528220-14 2001 These data show that gonadal steroids differentially regulate the effects of Delta(9)-THC on both CRH and POMC gene expression in the hypothalamus of male and female rats, suggesting gender differences in the reaction to cannabinoids. Steroids 29-37 proopiomelanocortin Rattus norvegicus 106-110 11357060-9 2001 The present results suggested that IGFBP-4, as well as GH, IGF-I, estradiol, LH and oxytocin, is a potent regulator of porcine ovarian steroid (progesterone), nonapeptide hormone (oxytocin), growth factor (IGF-I) and growth factor-binding protein (IGFBP-3) release. Steroids 135-142 insulin like growth factor binding protein 4 Homo sapiens 35-42 11278753-8 2001 Inhibition of movement by the FKBP52 PPIase domain is abrogated in cells treated with colcemid to eliminate microtubules prior to steroid addition. Steroids 130-137 peptidylprolyl isomerase (cyclophilin)-like 6 Mus musculus 37-43 11446734-0 2001 Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review. Steroids 125-133 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 28-31 11446734-4 2001 We concluded that an adequate dose of steroids can be the first line of therapy for PRCA after ABO-mismatched allogeneic stem cell transplantation. Steroids 38-46 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 95-98 11313303-1 2001 BACKGROUND & AIMS: ISIS-2302, an antisense oligonucleotide directed against intercellular adhesion molecule 1, was effective in steroid refractory Crohn"s disease in a pilot trial. Steroids 132-139 intercellular adhesion molecule 1 Homo sapiens 80-113 11306716-5 2001 The docking of synthetic compounds bearing C-11beta hydrophobic substituents within the ligand binding pocket of hAR demonstrated that precise positions of the steroid, such as C-11 and C-17, are in close contact with some residues on the receptor, C-11 with Gly 708 and C-17 with Asn705 and Thr877. Steroids 160-167 aldo-keto reductase family 1 member C4 Homo sapiens 43-47 11306716-5 2001 The docking of synthetic compounds bearing C-11beta hydrophobic substituents within the ligand binding pocket of hAR demonstrated that precise positions of the steroid, such as C-11 and C-17, are in close contact with some residues on the receptor, C-11 with Gly 708 and C-17 with Asn705 and Thr877. Steroids 160-167 aldo-keto reductase family 1 member C4 Homo sapiens 177-181 11331666-2 2001 In this study, we focused on retinoic acid receptors (RAR and RXR) which are ligand-dependent transcription factors belonging to the large family of steroid hormones and are expected to affect to cell growth and differentiation in the endometrium. Steroids 149-165 retinoid X receptor alpha Homo sapiens 62-65 11331668-6 2001 In addition, to evaluate the involvement of inflammatory mediators and ovarian steroid hormones in the production of ENA-78 by ESC was evaluated by in-vitro studies. Steroids 79-95 C-X-C motif chemokine ligand 5 Homo sapiens 117-123 11259263-1 2001 A hallmark of reproductive aging in rats is a delay in the initiation and peak, and a decrease in the amplitude, of both proestrous and steroid-induced surges of LH and a decrease in the number of GnRH neurons that express Fos during the surge. Steroids 136-143 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 223-226 11259269-1 2001 Granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion from epithelial cells lining the female reproductive tract is induced during early pregnancy by ovarian steroid hormones and constituents of seminal plasma. Steroids 172-188 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 0-48 11259269-1 2001 Granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion from epithelial cells lining the female reproductive tract is induced during early pregnancy by ovarian steroid hormones and constituents of seminal plasma. Steroids 172-188 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 50-56 11304832-1 2001 The benzodiazepine receptor (peripheral) (BZRP) plays an important role in the steroid syntheses of the adrenal glands and brain, which is possibly involved in the pathophysiology of mood disorders. Steroids 79-86 translocator protein Homo sapiens 42-46 11344940-4 2001 In hyperandrogenic children and women, the pathogenic mechanism of a subtle abnormality in adrenal 3 beta-HSD activity, determined by modestly elevated ACTH stimulated delta-5 steroid levels, which led to the diagnosis of mild nonclassic 3 beta-HSD deficiency in the past, is outside of the type II 3 beta-HSD gene which encodes adrenals and gonads in humans and remains to be further explored. Steroids 176-183 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 99-109 11255274-1 2001 BACKGROUND AND OBJECTIVES: Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. Steroids 129-136 interleukin 10 Homo sapiens 27-41 11255274-1 2001 BACKGROUND AND OBJECTIVES: Interleukin-10 (IL-10) is a pleiotropic cytokine which increases bcl-2 levels and protects cells from steroid or doxorubicin-induced apoptosis. Steroids 129-136 interleukin 10 Homo sapiens 43-48 11179736-1 2001 Human colorectal cancer cells not only express the nuclear vitamin D receptor (VDR) but are also endowed with 25-hydroxy-vitamin D(3)-1alpha-hydroxylase activity and therefore are able to produce the specific ligand for the VDR, the hormonally active steroid 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)). Steroids 251-258 vitamin D receptor Homo sapiens 224-227 11179736-3 2001 This indicates that, through up-regulation of this intrinsic 1alpha,25(OH)(2)D(3)/VDR system which mediates the anti-mitotic effects of the steroid hormone, colorectal cancer cells are apparently able to increase their potential for an autocrine counter-regulatory response to neoplastic cell growth, particularly in the early stages of malignancy. Steroids 140-155 vitamin D receptor Homo sapiens 82-85 11165039-1 2001 Recently, pregnane X receptor (PXR) has been described to mediate the genomic effects of several steroid hormones, such as progesterone (P), glucocorticoid (Dex), pregnenolone (Preg), and xenobiotics through the cytochrome P-450 3A gene family (CYP3A), which are monooxygenases, responsible for the oxidative metabolism of some endogenous substrates and xenobiotics. Steroids 97-113 nuclear receptor subfamily 1, group I, member 2 Mus musculus 10-29 11165039-1 2001 Recently, pregnane X receptor (PXR) has been described to mediate the genomic effects of several steroid hormones, such as progesterone (P), glucocorticoid (Dex), pregnenolone (Preg), and xenobiotics through the cytochrome P-450 3A gene family (CYP3A), which are monooxygenases, responsible for the oxidative metabolism of some endogenous substrates and xenobiotics. Steroids 97-113 nuclear receptor subfamily 1, group I, member 2 Mus musculus 31-34 11165039-9 2001 These data suggest that PXR may play certain roles in perinatal period, possibly in the protection of the feto-maternal system from the toxic effect of endogenous steroids and foreign substrates. Steroids 163-171 nuclear receptor subfamily 1, group I, member 2 Mus musculus 24-27 11053423-1 2001 The steroid hydroxylating system of adrenal cortex mitochondria consists of the membrane-attached NADPH-dependent adrenodoxin reductase (AR), the soluble one-electron transport protein adrenodoxin (Adx), and a membrane-integrated cytochrome P450 of the CYP11 family. Steroids 4-11 ferredoxin 1 Homo sapiens 114-125 11053423-1 2001 The steroid hydroxylating system of adrenal cortex mitochondria consists of the membrane-attached NADPH-dependent adrenodoxin reductase (AR), the soluble one-electron transport protein adrenodoxin (Adx), and a membrane-integrated cytochrome P450 of the CYP11 family. Steroids 4-11 ferredoxin 1 Homo sapiens 198-201 11247320-9 2001 In 5 out of 11 patients of childbearing age taking steroids for their SSc (< 10 mg/daily) DHEAS levels were significantly lower than in patients not taking steroids (p = 0.01). Steroids 51-59 sulfotransferase family 2A member 1 Homo sapiens 93-98 11247320-10 2001 On the contrary, 16 out of 29 postmenopausal women using steroids had lower DHEAS concentrations than in patients not taking steroids, although the difference was not statistically significant. Steroids 57-65 sulfotransferase family 2A member 1 Homo sapiens 76-81 11255259-0 2001 Expression of RFG/ELE1alpha/ARA70 in normal and malignant prostatic epithelial cell cultures and lines: regulation by methylation and sex steroids. Steroids 138-146 nuclear receptor coactivator 4 Homo sapiens 14-17 11244496-4 2001 Employing rat hypothalamic neuron cultures, we report here that another important ovarian steroid, progesterone, also augments dopamine D5 receptor expression in hypothalamic atrial natriuretic factor (ANP) neurons. Steroids 90-97 natriuretic peptide A Rattus norvegicus 175-200 11282290-1 2000 In the present work, the activity of mouse renal ornithine decarboxylase (ODC) from CBA female mice was used as a biological marker to detect (anti)androgenic activity of different groups of endocrine disruptors and steroids. Steroids 216-224 ornithine decarboxylase, structural 1 Mus musculus 49-72 11282290-1 2000 In the present work, the activity of mouse renal ornithine decarboxylase (ODC) from CBA female mice was used as a biological marker to detect (anti)androgenic activity of different groups of endocrine disruptors and steroids. Steroids 216-224 ornithine decarboxylase, structural 1 Mus musculus 74-77 11090106-6 2000 NCX-1015 dose-dependently induced the steroid sensitive cell surface marker CD163 in human peripheral blood mononuclear cells (PBMCs). Steroids 38-45 T cell leukemia homeobox 2 Homo sapiens 0-3 11090106-6 2000 NCX-1015 dose-dependently induced the steroid sensitive cell surface marker CD163 in human peripheral blood mononuclear cells (PBMCs). Steroids 38-45 CD163 molecule Homo sapiens 76-81 11090106-17 2000 In conclusion we show that NCX-1015 is more potent than prednisolone in controlling several, though not all, parameters of acute and chronic inflammation, and propose that this effect may be due to a co-operation between the steroid moiety and nitric oxide or related species released in biological fluids. Steroids 225-232 T cell leukemia homeobox 2 Homo sapiens 27-30 11155097-10 2000 The increased level of P450c17, DHEA-ST, P450 oxidoreductase, and cytochrome b5, and the decreased level of 3betaHSD in the reticularis is likely to contribute to increased C19 steroid production during adrenarche. Steroids 177-184 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 108-116 11087380-9 2000 In the five-protein system, Hip prevents inhibition of assembly by the hsp70 co-chaperone BAG-1, and cotransfection of Hip with BAG-1 opposes BAG-1 reduction of steroid binding activity in COS cells. Steroids 161-168 heat shock protein family A (Hsp70) member 4 Homo sapiens 71-76 11075820-2 2000 Here various steroids were screened for potential endogenous chemicals that may activate CAR, using the NR1 enhancer and Cyp2b10 induction in transfected HepG2 cell and/or in mouse primary hepatocytes as the experimental criteria. Steroids 13-21 nuclear receptor subfamily 1 group I member 3 Homo sapiens 89-92 11005250-2 2000 In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, specially in the rat, monkey and human. Steroids 51-59 androgen receptor Rattus norvegicus 143-160 11005250-2 2000 In order to determine the sites of action of these steroids, studies have been performed to identify at the cellular level the localization of androgen receptor (AR) and the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, specially in the rat, monkey and human. Steroids 51-59 androgen receptor Rattus norvegicus 162-164 11059615-6 2000 Before steroid therapy, the levels of IL-10 in the CS group showed a significantly positive correlation with levels of ACE (r=0.868, p<0.05) and lysozyme (r=0.890, p<0.05). Steroids 7-14 interleukin 10 Homo sapiens 38-43 11059615-7 2000 In 5 patients who were analyzed before and after steroid therapy, the levels of IL-10 tended to correlate with a decrease of an abnormal accumulation in gallium-67 citrate. Steroids 49-56 interleukin 10 Homo sapiens 80-85 10999937-6 2000 In contrast, C11-substituted steroids with a 17gamma-lactonic ring displayed antagonist properties with hMR and acted as potent agonists with A773G. Steroids 29-37 aldo-keto reductase family 1 member C4 Homo sapiens 13-16 10906322-2 2000 Glucocorticoid action within individual cells is potently modulated by 11beta-hydroxysteroid dehydrogenase (11beta-HSD), which, by interconverting active and inert glucocorticoids, determines steroid access to receptors. Steroids 85-92 hydroxysteroid 11-beta dehydrogenase 1 Mus musculus 108-118 11465080-8 2000 The UGT2 subfamily consists of numerous enzymes which catalyze the glucuronidation of a diverse chemical base including steroids, bile acids, and opioids. Steroids 120-128 UDP-glucose glycoprotein glucosyltransferase 2 Homo sapiens 4-8 11009092-0 2000 Sex steroids induce apoptosis of CD8+CD4+ double-positive thymocytes via TNF-alpha. Steroids 4-12 CD8a molecule Homo sapiens 33-36 11009092-3 2000 Here we show that a typical sex steroid, testosterone, specifically targets CD8+CD4+ double-positive (DP) thymocytes for apoptosis via TNF-alpha. Steroids 32-39 CD8a molecule Homo sapiens 76-79 10934396-0 2000 Selective Hydroxylation of a Steroid at C-9 by an Artificial Cytochrome P-450 We thank the National Institutes of Health, the National Science Foundation, and the Environmental Protection Agency for financial support of this research. Steroids 29-36 complement C9 Homo sapiens 40-43 11082899-8 2000 CONCLUSIONS: DHEAS might play an important role during girls puberty although its exact role is very difficult to establish because this steroid works mainly as a precursor for both estrogen and androgen formation. Steroids 137-144 sulfotransferase family 2A member 1 Homo sapiens 13-18 10987130-3 2000 Recently, GFAP mRNA expression in cultured astrocytes has been shown to be modulated by various steroid hormones, such as progesterone, testosterone, and their 5 alpha-reduced metabolites. Steroids 96-112 glial fibrillary acidic protein Rattus norvegicus 10-14 10987130-4 2000 Therefore, it seems possible that steroid hormones may play a potential role in the enhancement of GFAP expression observed following toluene exposure. Steroids 34-41 glial fibrillary acidic protein Rattus norvegicus 99-103 10890372-4 2000 The series of steroids complexing the corticosteroid (CBG) and testosterone (TBG) globulins, which forms a benchmark measuring the performance of the methods in molecular design, and a series of benzoic acids described by the Hammett sigma constants is used for testing the method. Steroids 14-22 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 54-57 10890372-4 2000 The series of steroids complexing the corticosteroid (CBG) and testosterone (TBG) globulins, which forms a benchmark measuring the performance of the methods in molecular design, and a series of benzoic acids described by the Hammett sigma constants is used for testing the method. Steroids 14-22 serpin family A member 7 Homo sapiens 77-80 11062844-1 2000 The aim of this study was to evaluate the effects of local steroid injection on both the clinical symptoms and motor and sensory conduction of the median nerve in carpal tunnel syndrome (CTS). Steroids 59-66 transthyretin Homo sapiens 187-190 10764743-0 2000 Stepwise assembly of a glucocorticoid receptor.hsp90 heterocomplex resolves two sequential ATP-dependent events involving first hsp70 and then hsp90 in opening of the steroid binding pocket. Steroids 167-174 heat shock protein family A (Hsp70) member 4 Homo sapiens 128-133 10764743-2 2000 Two proteins, hsp90 and hsp70, are required for the activation of steroid binding activity that occurs with heterocomplex assembly, and three proteins, Hop, hsp40, p23, act as co-chaperones that enhance activation and assembly (Morishima, Y., Kanelakis, K. C., Silverstein, A.M., Dittmar, K. D., Estrada, L., and Pratt, W. B. Steroids 66-73 heat shock protein family A (Hsp70) member 4 Homo sapiens 24-29 10764743-7 2000 After elimination of free hsp70, these preformed GR.hsp70 complexes can be activated to the steroid binding state by the hsp70 free assembly system in a second ATP-dependent step. Steroids 92-99 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-57 10764743-7 2000 After elimination of free hsp70, these preformed GR.hsp70 complexes can be activated to the steroid binding state by the hsp70 free assembly system in a second ATP-dependent step. Steroids 92-99 heat shock protein family A (Hsp70) member 4 Homo sapiens 52-57 10917466-1 2000 Many studies have demonstrated that, in asthma, serum levels of eosinophil cationic protein (ECP) are related to the activity and severity of the disease and can be used to evaluate the response to steroid treatment. Steroids 198-205 ribonuclease A family member 3 Homo sapiens 64-91 10917466-1 2000 Many studies have demonstrated that, in asthma, serum levels of eosinophil cationic protein (ECP) are related to the activity and severity of the disease and can be used to evaluate the response to steroid treatment. Steroids 198-205 ribonuclease A family member 3 Homo sapiens 93-96 10913783-1 2000 Androgen-receptor upregulation that occurs with androgenic-anabolic steroid (AAS) administration may be mediated by AAS metabolites, dihydrotestosterone (DHT), and estrogen. Steroids 68-75 androgen receptor Rattus norvegicus 0-17 10775173-15 2000 These findings support the contention that insulin and/or insulin-dependent changes in glucose availability modulate LH(GnRH) pulse frequency, and that such effects are potentiated by, but not dependent upon, gonadal steroids. Steroids 217-225 LOC105613195 Ovis aries 58-65 10853869-5 2000 The IL-17-induced neutrophil recruitment is mediated via induced CXC chemokine release through steroid-sensitive mechanisms and is modulated by release of endogenous tachykinins. Steroids 95-102 interleukin 17A Homo sapiens 4-9 11424949-1 2000 The present paper summarizes recent results we have obtained while studying the effect of sex steroids on the gene expression of two peripheral myelin proteins, the glycoprotein Po (Po) and the peripheral myelin protein 22 (PMP22). Steroids 94-102 peripheral myelin protein 22 Rattus norvegicus 194-222 11424949-1 2000 The present paper summarizes recent results we have obtained while studying the effect of sex steroids on the gene expression of two peripheral myelin proteins, the glycoprotein Po (Po) and the peripheral myelin protein 22 (PMP22). Steroids 94-102 peripheral myelin protein 22 Rattus norvegicus 224-229 11424949-4 2000 Taken together, these observations showing the positive effects of sex steroid hormones on the gene expressions of Po and PMP22, suggest that a treatment with these molecules or their synthetic agonists may be useful in cases in which the rebuilding of myelin is necessary. Steroids 71-87 peripheral myelin protein 22 Rattus norvegicus 122-127 10779377-1 2000 The human UDP glucuronosyltransferase, UGT2B7, is expressed in the liver and gastrointestinal tract, where it catalyzes the glucuronidation of steroids and bile acids. Steroids 143-151 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 39-45 10897620-2 2000 The aim of the study was to determine whether the activity of T-helper-1 (Th1) and T-helper-2 (Th2) cells are predictive for steroid sensitivity in children with primary NS. Steroids 125-132 negative elongation factor complex member C/D Homo sapiens 74-77 10897620-8 2000 We conclude that prior to treatment the Th1 and Th2 cell activity provides a useful tool to evaluate the probability of steroid sensitivity in patients with primary NS. Steroids 120-127 negative elongation factor complex member C/D Homo sapiens 40-43 10757535-0 2000 Down-regulation of delta opioid receptor mRNA by an anabolic steroid in neuronal hybrid cells. Steroids 61-68 opioid receptor, delta 1 Mus musculus 19-40 10681370-2 2000 Although the pregnane X receptor is reported to mediate steroid and drug activation of CYP3A via a conserved cis-element in CYP3A genes, discrepancies exist between the induction of the endogenous CYP3A genes and the activation of the pregnane X receptor. Steroids 56-63 nuclear receptor subfamily 1, group I, member 2 Mus musculus 13-32 10681370-11 2000 Thus, there are distinctly different essential requirements of CYP3A, CYP2B, and P-450 reductase genes for the glucocorticoid receptor in their induction by steroids and drugs. Steroids 157-165 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 63-68 10704864-1 2000 BAG-1 is a family of proteins with diverse activities that range in cultured cells from protection against programmed cell death through to regulation of steroid hormone action. Steroids 154-169 BCL2-associated athanogene 1 Mus musculus 0-5 10832596-0 2000 Differential steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in breast cancer cell lines. Steroids 13-28 RBPJ pseudogene 3 Homo sapiens 71-74 10832596-1 2000 We have investigated the steroid hormone regulation of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) in the breast cancer cell lines BT-474, T-47D, MFM-223, MCF-7, ZR-75-1, MDA-MB-435, and BT-20. Steroids 25-40 RBPJ pseudogene 3 Homo sapiens 83-86 10671943-0 2000 Serum levels of growth hormone binding protein in children with normal and precocious puberty: relation to age, gender, body composition and gonadal steroids. Steroids 149-157 growth hormone receptor Homo sapiens 16-46 10671943-1 2000 AIM: To study the regulation of GHBP serum levels by gonadal steroids in normal and precocious puberty. Steroids 61-69 growth hormone receptor Homo sapiens 32-36 10647874-3 2000 Acute rejection gave a characteristic and marked increase in blood C3a, C4a and gamma-glutamyl transferase (gammaGT) levels, which rapidly resolved after high dose steroid treatment. Steroids 164-171 complement C3 Homo sapiens 67-70 10726960-1 2000 AIMS/BACKGROUND: Dehydroepiandrosterone sulphotransferase (DHEA ST) is the enzyme responsible for sulphation of lithocholic acid and other potentially hepatotoxic steroids. Steroids 163-171 sulfotransferase family 2A member 1 Homo sapiens 17-57 10726960-1 2000 AIMS/BACKGROUND: Dehydroepiandrosterone sulphotransferase (DHEA ST) is the enzyme responsible for sulphation of lithocholic acid and other potentially hepatotoxic steroids. Steroids 163-171 sulfotransferase family 2A member 1 Homo sapiens 59-66 10664831-9 2000 CONCLUSIONS: The anomalous positive correlation between cognitive dysfunction and DHEA-S levels, and the inverse correlation between cortisol levels and depressive symptoms, suggests that the relationships between psychiatric symptomatology and levels of steroids that are part of the hypothalamic-pituitary adrenal axis are different in the frail elderly population from that of younger and heartier populations. Steroids 255-263 sulfotransferase family 2A member 1 Homo sapiens 82-88 10614640-10 2000 The involvement of calcium in steroid secretion induced by TTN has also been investigated. Steroids 30-37 TTN Canis lupus familiaris 59-62 10614640-11 2000 Administration of mibefradil significantly reduced the TTN-evoked stimulation of steroid production, whereas nifedipine was devoid of effect. Steroids 81-88 TTN Canis lupus familiaris 55-58 10611261-0 2000 Tissue differences but limited sex steroid responsiveness of c-fos and c-jun in human fibroids and myometrium. Steroids 35-42 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 61-66 10611261-0 2000 Tissue differences but limited sex steroid responsiveness of c-fos and c-jun in human fibroids and myometrium. Steroids 35-42 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 71-76 10611261-1 2000 Sex steroids influence the growth of mammalian uterine tissues and the proto-oncogenes c-fos and c-jun have been implicated in the cascade of cellular events induced by the cyclic influence of oestrogen and progesterone. Steroids 4-12 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 87-92 10611261-1 2000 Sex steroids influence the growth of mammalian uterine tissues and the proto-oncogenes c-fos and c-jun have been implicated in the cascade of cellular events induced by the cyclic influence of oestrogen and progesterone. Steroids 4-12 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 97-102 10617714-9 2000 Using DD RT-PCR an amplicon that shared 100% sequence homology with the human mitochondrial cytochrome b gene was detected in the hemangioma biopsy after steroid treatment. Steroids 154-161 mitochondrially encoded cytochrome b Homo sapiens 92-104 10617714-10 2000 CONCLUSIONS: The regression of this hemangioma subsequent to steroid therapy was accompanied by a significant increase in mast cell density, reduced transcription of several cytokines, and an enhanced expression of the mitochondrial cytochrome b gene. Steroids 61-68 mitochondrially encoded cytochrome b Homo sapiens 233-245 11072801-0 2000 Effect of steroid hormone deprivation on the expression of ecto-ATPase in distinct brain regions of female rats. Steroids 10-25 CEA cell adhesion molecule 1 Rattus norvegicus 59-70 11072801-3 2000 In the present study we have examined the effect of gonadal (OVX) or adrenal (ADX) steroid hormone deprivation on the activity and expression of synaptic membrane ecto-ATPase in three extrahypothalamic brain areas of female rats, primarily not associated with reproductive function. Steroids 83-98 CEA cell adhesion molecule 1 Rattus norvegicus 163-174 11112053-12 2000 After steroid treatment the intensity of ICAM-1 decreased significantly in sinusoids (1.5 +/- 0.67; P < 0.05) and in perivenular hepatocytes (0.25 +/- 0.86; P < 0.05). Steroids 6-13 intercellular adhesion molecule 1 Homo sapiens 41-47 10630412-1 1999 Trypsin digestion of steroid-free, but not steroid-bound, rat glucocorticoid receptor (GR) has recently been reported to occur at arginine-651 (R651). Steroids 21-28 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 87-89 10630412-3 1999 This hypothesis is supported by the current model of the GR ligand binding domain (LBD), which is based on the X-ray structures of several related receptor LBDs and places R651 in the middle of the putative alpha-helix 6 (649-EQRMS-653 of rat GR), close to the bound steroid. Steroids 267-274 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 57-59 10550133-9 1999 With respect to steroid receptor status, BRCA2-associated tumors were more likely to be steroid receptor-positive, especially regarding progesterone receptor status (100% v 76.7% positive, respectively; P =.06). Steroids 16-23 BRCA2 DNA repair associated Homo sapiens 41-46 10550133-9 1999 With respect to steroid receptor status, BRCA2-associated tumors were more likely to be steroid receptor-positive, especially regarding progesterone receptor status (100% v 76.7% positive, respectively; P =.06). Steroids 88-95 BRCA2 DNA repair associated Homo sapiens 41-46 10562469-11 1999 Furthermore, it appears that lymphocyte HSD17B1 and SRD5A1 are regulated to some extent by specific steroids. Steroids 100-108 steroid 5 alpha-reductase 1 Homo sapiens 52-58 10527129-0 1999 The effects of exogenous growth hormone on follicular steroid secretion and ovulation rate in sheep. Steroids 54-61 somatotropin Ovis aries 25-39 10517672-1 1999 Rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD; AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, inactivates nearly all steroid hormones by converting 5alpha- and 5beta-dihydrosteroids to their respective 3alpha,5alpha- and 3alpha,5beta-tetrahydrosteroids and protects against circulating steroid hormone excess. Steroids 155-171 aldo-keto reductase family 1, member C14 Rattus norvegicus 53-63 10517672-1 1999 Rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD; AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, inactivates nearly all steroid hormones by converting 5alpha- and 5beta-dihydrosteroids to their respective 3alpha,5alpha- and 3alpha,5beta-tetrahydrosteroids and protects against circulating steroid hormone excess. Steroids 155-171 aldo-keto reductase family 1, member C14 Rattus norvegicus 68-74 10517672-1 1999 Rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD; AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, inactivates nearly all steroid hormones by converting 5alpha- and 5beta-dihydrosteroids to their respective 3alpha,5alpha- and 3alpha,5beta-tetrahydrosteroids and protects against circulating steroid hormone excess. Steroids 155-170 aldo-keto reductase family 1, member C14 Rattus norvegicus 53-63 10517672-1 1999 Rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD; AKR1C9), a member of the aldo-keto reductase (AKR) superfamily, inactivates nearly all steroid hormones by converting 5alpha- and 5beta-dihydrosteroids to their respective 3alpha,5alpha- and 3alpha,5beta-tetrahydrosteroids and protects against circulating steroid hormone excess. Steroids 155-170 aldo-keto reductase family 1, member C14 Rattus norvegicus 68-74 10517672-14 1999 These results indicate that members of the NF1 transcription factor family regulate high constitutive expression of the rat 3alpha-HSD/DD gene that is responsible for steroid hormone inactivation. Steroids 167-182 aldo-keto reductase family 1, member C14 Rattus norvegicus 124-134 10500147-5 1999 The crystal structure of 3alpha-HSD indicates that the mature steroid binding pocket consists of 10 residues located on five loops, including loop A and the mobile loops B and C. 3alpha-HSD was converted to 20alpha-HSD by replacing these loops with those found in 20alpha-HSD. Steroids 62-69 aldo-keto reductase family 1 member C4 Homo sapiens 25-35 10500147-5 1999 The crystal structure of 3alpha-HSD indicates that the mature steroid binding pocket consists of 10 residues located on five loops, including loop A and the mobile loops B and C. 3alpha-HSD was converted to 20alpha-HSD by replacing these loops with those found in 20alpha-HSD. Steroids 62-69 aldo-keto reductase family 1 member C4 Homo sapiens 179-189 10413522-1 1999 Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption. Steroids 176-183 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 235-242 10529008-1 1999 In this work, UDP-glucuronosyltransferases (UGTs), UGT1A3, 2B7(H268) and 2B7(Y268), stably expressed in human embryonic kidney cells (HK293) were used to assess glucuronidation activities with a variety of steroid hormone and bile acid substrates. Steroids 206-221 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 51-57 10529008-6 1999 Similarly, androsterone, a 3alpha-hydroxylated androgenic steroid, was glucuronidated at very high rates by expressed UGT2B7. Steroids 58-65 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 118-124 10529008-8 1999 Other structural discrimination was found with UGT2B7 which had activity toward estriol and estradiol exclusively at the 17beta-OH position, yielding the cholestatic steroid D-ring glucuronides. Steroids 166-173 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 47-53 10369776-0 1999 The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. Steroids 92-99 ferredoxin reductase Bos taurus 17-38 10369776-1 1999 Adrenodoxin reductase is a monomeric 51 kDa flavoenzyme that is involved in the biosynthesis of all steroid hormones. Steroids 100-116 ferredoxin reductase Bos taurus 0-21 10336931-5 1999 Steroid treatment returned the total eosinophil count and serum ECP to normal, with satisfactory improvement in clinical features. Steroids 0-7 ribonuclease A family member 3 Homo sapiens 64-67 10350561-3 1999 For a number of neuroactive steroids, sulfation at C-3 reverses the direction of modulation from positive to negative, suggesting that sulfation could be an important control point for the activity of endogenous neurosteroids. Steroids 28-36 complement C3 Rattus norvegicus 51-54 10411324-0 1999 The role of sex steroids in the oxytocin hormone system. Steroids 16-24 oxytocin/neurophysin I prepropeptide Homo sapiens 32-40 10411324-6 1999 The current consensus suggests that the sex steroids are acting indirectly on both the OT and OTR genes, possibly involving intermediate transcription factors or cofactors. Steroids 44-52 oxytocin/neurophysin I prepropeptide Homo sapiens 87-89 10411324-8 1999 Due to the OT system being so ancient and fundamental to all aspects of reproduction, it is likely that the mechanisms by which the sex steroids influence this system are going to be of general importance to many other basic aspects of reproductive control. Steroids 136-144 oxytocin/neurophysin I prepropeptide Homo sapiens 11-13 10340743-3 1999 An effect of this steroid, which is known to interact with the GABA(A) receptor, would not be surprising, since in the present study we show the presence in Schwann cells and in the sciatic nerve of the messengers for several subunits (alpha2, alpha3, beta1, beta2, and beta3) of the GABA(A) receptor. Steroids 18-25 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 236-257 10375178-0 1999 Different absorption behaviors among steroid hormones due to possible interaction with P-glycoprotein in the rat small intestine. Steroids 37-53 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 87-101 10375178-7 1999 It was demonstrated that there was a plural P-gp family, which had different substrate specificities, in the rat intestine and that steroid hormones interacted with them as substrates or inhibitors in a very complex manner. Steroids 132-148 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 44-48 10340591-7 1999 However, levels of total cytochrome b5 immunoreactive protein and levels of the low molecular weight immunoreactive cytochrome b5 were correlated to fat 16-androstene steroid concentrations (r = .59, P < .001; r = .72, P = .0001, respectively). Steroids 167-174 cytochrome b5 type A Sus scrofa 116-129 10208874-0 1999 The melanocortin 4 receptor mediates leptin stimulation of luteinizing hormone and prolactin surges in steroid-primed ovariectomized rats. Steroids 103-110 melanocortin 4 receptor Rattus norvegicus 4-27 10215860-6 1999 Furthermore, SR-BI mRNA was expressed to similar levels in human primary adrenocortical and adrenocortical carcinoma NCI-H295 cells, indicating its presence in the steroid-producing cells. Steroids 164-171 scavenger receptor class B member 1 Homo sapiens 13-18 10418986-1 1999 In vitro studies using isolated cells, mitochondria and submitochondrial fractions demonstrated that in steroid synthesizing cells, the peripheral-type benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein, preferentially located in the outer/inner membrane contact sites, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 104-111 translocator protein Homo sapiens 136-175 10418986-1 1999 In vitro studies using isolated cells, mitochondria and submitochondrial fractions demonstrated that in steroid synthesizing cells, the peripheral-type benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein, preferentially located in the outer/inner membrane contact sites, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 104-111 translocator protein Homo sapiens 177-180 10418986-1 1999 In vitro studies using isolated cells, mitochondria and submitochondrial fractions demonstrated that in steroid synthesizing cells, the peripheral-type benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein, preferentially located in the outer/inner membrane contact sites, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 425-432 translocator protein Homo sapiens 136-175 10418986-1 1999 In vitro studies using isolated cells, mitochondria and submitochondrial fractions demonstrated that in steroid synthesizing cells, the peripheral-type benzodiazepine receptor (PBR) is an outer mitochondrial membrane protein, preferentially located in the outer/inner membrane contact sites, involved in the regulation of cholesterol transport from the outer to the inner mitochondrial membrane, the rate-determining step in steroid biosynthesis. Steroids 425-432 translocator protein Homo sapiens 177-180 10418986-3 1999 Targeted disruption of the PBR gene in Leydig cells in vitro resulted in the arrest of cholesterol transport into mitochondria and steroid formation; transfection of the mutant cells with a PBR cDNA rescued steroidogenesis demonstrating an obligatory role for PBR in cholesterol transport. Steroids 131-138 translocator protein Homo sapiens 27-30 10230405-5 1999 We propose that this single modification of SF-1 and the subsequent recruitment of nuclear receptor cofactors couple extracellular signals to steroid and peptide hormone synthesis, thereby maintaining dynamic homeostatic responses in stress and reproduction. Steroids 142-149 splicing factor 1 Homo sapiens 44-48 10092698-1 1999 BACKGROUND: Steroid resistant asthma (SRA) represents a small subgroup of those patients who have asthma and who are difficult to manage. Steroids 12-19 steroid receptor RNA activator 1 Homo sapiens 38-41 10026121-0 1999 Steroid regulation of retinol-binding protein in the ovine oviduct. Steroids 0-7 retinol binding protein 4 Homo sapiens 22-45 10084681-6 1999 We show that the death of these neurons is dependent upon the fall in the titer of the steroid hormone 20-hydroxyecdysone that occurs at the end of metamorphosis, and demonstrate that the accumulation of both reaper and grim transcripts is inhibited by this steroid hormone. Steroids 258-273 grim Drosophila melanogaster 220-224 10202995-0 1999 Serum eosinophil cationic protein (ECP) as a mediator of inflammation in acute asthma, during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule. Steroids 181-189 ribonuclease A family member 3 Homo sapiens 6-33 10202995-0 1999 Serum eosinophil cationic protein (ECP) as a mediator of inflammation in acute asthma, during resolution and during the monitoring of stable asthmatic patients treated with inhaled steroids according to a dose reduction schedule. Steroids 181-189 ribonuclease A family member 3 Homo sapiens 35-38 10202995-1 1999 OBJECTIVE AND DESIGN: The main objective was to establish the level of serum ECP in a group of adult asthmatic patients with acute exacerbation and the following resolution and in another group of adult, stable asthmatic patients during reduction of inhaled steroids. Steroids 258-266 ribonuclease A family member 3 Homo sapiens 77-80 9925647-5 1999 SR-B1 exhibits broad ligand specificity and, in animal models, appears to be regulated by the action of pituitary hormones that stimulate steroidogenesis, suggesting an important role for steroid hormone production in supplying precursor cholesterol. Steroids 188-203 scavenger receptor class B member 1 Homo sapiens 0-5 10202863-0 1999 The expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and its regulation by ovarian steroids in rat uterine stromal cells. Steroids 106-114 colony stimulating factor 2 Rattus norvegicus 18-66 10202863-0 1999 The expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and its regulation by ovarian steroids in rat uterine stromal cells. Steroids 106-114 colony stimulating factor 2 Rattus norvegicus 68-74 9988273-4 1999 Here we show that young adult female Bax-/- mice possess threefold more primordial follicles in their ovarian reserve than their wild-type sisters, and this surfeit of follicles is maintained in advanced chronological age, such that 20-22-month-old female Bax-/- mice possess hundreds of follicles at all developmental stages and exhibit ovarian steroid-driven uterine hypertrophy. Steroids 346-353 BCL2-associated X protein Mus musculus 37-40 9989598-1 1999 Adrenodoxin reductase is an essential component of the mitochondrial monooxygenase systems that are involved in the synthesis of steroid hormones and related compounds. Steroids 129-145 ferredoxin reductase Bos taurus 0-21 10516402-3 1999 The recent identification of a second type of estrogen receptor called estrogen receptor beta or ERbeta has raised new issues about the action of steroid hormones in the brain. Steroids 146-162 estrogen receptor beta Sturnus vulgaris 97-103 10516402-13 1999 The lack of ERbeta mRNA expression in HVc is consistent with the hypothesis that ERalpha is preferentially involved in reproductive behaviors while ERbeta is involved in the steroid regulation of other neural functions. Steroids 174-181 estrogen receptor beta Sturnus vulgaris 148-154 10100477-0 1999 Evidence for the regulation of prostatic oxytocin by gonadal steroids in the rat. Steroids 61-69 oxytocin/neurophysin I prepropeptide Homo sapiens 41-49 9891625-2 1998 Thirty years of research has documented the beneficial effect of antenatal CS on fetal lung maturation, and antenatal steroid in combination with postnatal surfactant remains the mainstay of prevention and therapy for RDS in preterm infants. Steroids 118-125 peripherin 2 Homo sapiens 218-221 9814482-1 1998 CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. Steroids 147-163 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 0-7 9784427-9 1998 In S115 cells, Fgf8 mRNA expression was induced in parallel to MMTV mRNA by androgen and glucocorticoids which supports the possibility that Fgf8 is controlled by the steroid-regulated MMTV-LTR. Steroids 167-174 fibroblast growth factor 8 Mus musculus 15-19 9784427-9 1998 In S115 cells, Fgf8 mRNA expression was induced in parallel to MMTV mRNA by androgen and glucocorticoids which supports the possibility that Fgf8 is controlled by the steroid-regulated MMTV-LTR. Steroids 167-174 fibroblast growth factor 8 Mus musculus 141-145 9712916-1 1998 Uteroglobin (UG) is a steroid-inducible, multifunctional, secreted protein with antiinflammatory and antichemotactic properties. Steroids 22-29 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 0-11 9712916-1 1998 Uteroglobin (UG) is a steroid-inducible, multifunctional, secreted protein with antiinflammatory and antichemotactic properties. Steroids 22-29 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 13-15 9698548-1 1998 The retinoid X receptor (RXR) is a member of the nuclear hormone receptor superfamily of transcriptional regulators and plays a central role in the retinoid and, through its ability to heterodimerize with other nuclear hormone receptors, non-steroid signaling pathways. Steroids 242-249 retinoid X receptor alpha Homo sapiens 4-23 9698548-1 1998 The retinoid X receptor (RXR) is a member of the nuclear hormone receptor superfamily of transcriptional regulators and plays a central role in the retinoid and, through its ability to heterodimerize with other nuclear hormone receptors, non-steroid signaling pathways. Steroids 242-249 retinoid X receptor alpha Homo sapiens 25-28 9692994-7 1998 kcat versus pH profiles for steroid oxidoreduction catalyzed by wild-type 3alpha-HSD exhibited a single ionizable group with a pK= 7.0-7.5, which has been assigned to Tyr 55. Steroids 28-35 aldo-keto reductase family 1 member C4 Homo sapiens 74-84 9687319-13 1998 These results show that ET-1 is released from the theca layer of mature bovine follicles in vitro and that it affects follicular steroids and PGE2 secretion. Steroids 129-137 endothelin 1 Bos taurus 24-28 9888598-7 1998 The cloning and the characterization of zebrafish P450scc and 3beta-HSD should facilitate study of steroidogenesis and human disease associated with steroid imbalance. Steroids 99-106 cytochrome P450, family 11, subfamily A, polypeptide 1 Danio rerio 50-57 9710008-2 1998 OBJECTIVE: To evaluate the effectiveness of commonly used oral medications such as diuretics, nonsteroid anti-inflammatory drugs (NSAIDs), and steroids in the treatment of CTS. Steroids 143-151 transthyretin Homo sapiens 172-175 9844393-9 1998 These findings suggest that DIP and humoral immune dysfunction were caused by asbestos exposure, and responded well to steroid treatment. Steroids 119-126 DIP Homo sapiens 28-31 9893760-2 1998 By contrast, in patients with steroid-resistant asthma (SRA), this proliferative response is only partially attenuated by steroids, which suggests that the T lymphocyte may harbour a key molecular defect in these patients. Steroids 30-37 steroid receptor RNA activator 1 Homo sapiens 56-59 10079390-3 1998 Recently, another hormone, the adrenal steroid dehydroepiandrosterone-sulfate (DHEAS), has appeared to exert antitumor effects similar to those previously described for MLT. Steroids 39-46 sulfotransferase family 2A member 1 Homo sapiens 79-84 9677630-11 1998 Steroid therapy diminishes the proteins, GM-CSF.RANTES and IL-8 as well as the messengers IL-4, IL-13 and IL-5. Steroids 0-7 C-C motif chemokine ligand 5 Homo sapiens 48-54 9608532-1 1998 To ascertain the function of an orphan nuclear receptor Nurr1, a transcription factor belonging to a large gene family that includes receptors for steroids, retinoids, and thyroid hormone, we generated Nurr1-null mice by homologous recombination. Steroids 147-155 nuclear receptor subfamily 4, group A, member 2 Mus musculus 56-61 9548257-3 1998 Although it is generally held that steroid hormones such as P4 act at a genomic level by binding to nuclear receptors and modulating the expression of specific target genes, we show here that the effect of P4 on uterine sensitivity to oxytocin involves direct, non-genomic action of P4 on the uterine oxytocin receptor (OTR), a member of the G-protein-coupled receptor family. Steroids 35-42 oxytocin/neurophysin I prepropeptide Homo sapiens 235-243 9543154-6 1998 Unlike purified IDBP, hsc-70 and hsp-70 were also competent binders of the gonadal steroid 17beta-estradiol (mean Kd for 25OHD3, 2.5 and 6.6 nmol/L by hsc-70 and hsp-70, respectively), but not of two other gonadal hormones, progesterone and testosterone. Steroids 83-90 heat shock protein family A (Hsp70) member 8 Homo sapiens 22-28 9540976-0 1998 Quantification of tyrosinase, TRP-1, and Trp-2 transcripts in human melanocytes by reverse transcriptase-competitive multiplex PCR--regulation by steroid hormones. Steroids 146-162 dopachrome tautomerase Homo sapiens 41-46 9540976-4 1998 All three steroids lead to an increase of about 1.5-2.5-fold of tyrosinase transcripts. Steroids 10-18 tyrosinase Homo sapiens 64-74 9617077-3 1998 Steroid 3 beta-hydroxysteroid dehydrogenase/delta 5-4-isomerase (3 beta-HSD) and 21-hydroxylase (P450c21) were present in the membrane of smooth endoplasmic reticulum (SER) of all cortical cells. Steroids 0-7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 65-75 9699880-9 1998 Third, steroid effects on the astrocyte marker glial fibrillary acidic protein (GFAP) points to a complex regulatory mechanism. Steroids 7-14 glial fibrillary acidic protein Rattus norvegicus 47-78 9699880-9 1998 Third, steroid effects on the astrocyte marker glial fibrillary acidic protein (GFAP) points to a complex regulatory mechanism. Steroids 7-14 glial fibrillary acidic protein Rattus norvegicus 80-84 9518642-10 1998 These data demonstrate that levels of trkA mRNA in the MS, and BDNF mRNA in the hippocampus, are affected by physiological changes in the levels of circulating gonadal steroids and are elevated in response to acute hormone replacement. Steroids 168-176 brain derived neurotrophic factor Homo sapiens 63-67 9524277-6 1998 Additionally, LEM1, the ABC transporter that selectively modulates the biological potency of steroids in yeast, although operative in YCR1, was not responsible for antiandrogen resistance. Steroids 93-101 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 14-18 9546661-3 1998 Here we provide evidence that in a reciprocal experiment, CYP11B2-specific amino acids at position 320 and 335 endowed CYP11B1 with an 18-oxidase function amounting to 20% of the CYP11B2 wild-type activity, thus changing the specificity of steroid hydroxylation by only one point mutation. Steroids 240-247 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 119-126 9501302-0 1998 Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Steroids 79-86 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 21-44 9475386-3 1998 The purpose of this study was to investigate whether high levels of steroids in the PCO correlate with the expression of multidrug resistance gene product P-glycoprotein (Pgp). Steroids 68-76 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 155-169 9475386-3 1998 The purpose of this study was to investigate whether high levels of steroids in the PCO correlate with the expression of multidrug resistance gene product P-glycoprotein (Pgp). Steroids 68-76 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 171-174 9475386-8 1998 It may be possible that progesterone interacts with the Pgp of these granulosa cells to modulate steroid efflux. Steroids 97-104 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 56-59 9571013-5 1998 We propose that testosterone facilitates odor-induced neuronal Fos expression either via its conversion to estradiol, and the subsequent action of this steroid at estrogen response elements on the c-fos gene, or via some indirect mechanism involving centrifugal control of AOB neurotransmission. Steroids 152-159 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 197-202 9564171-1 1998 The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily. Steroids 165-172 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 89-107 9564171-1 1998 The vitamin D hormone, 1,25-dihydroxyvitamin D3, functions by way of a nuclear receptor (vitamin D receptor [VDR]) in a manner analogous to the other members of the steroid-thyroid hormone superfamily. Steroids 165-172 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 109-112 9452136-2 1998 Using steroidogenic cell submitochondrial fractions, mitochondrial preparations, various cell models, and animal models and with the help of pharmacological, biochemical, morphological, and molecular approaches, we provide evidence that the peripheral-type benzodiazepine receptor mediates the intramitochondrial cholesterol transport and the subsequent adrenal, gonadal, placental, and brain steroid biosynthesis. Steroids 6-13 translocator protein Homo sapiens 241-280 9490746-6 1998 Sequence analysis revealed that DWF4 encodes a cytochrome P450 monooxygenase with 43% identity to the putative Arabidopsis steroid hydroxylating enzyme CONSTITUTIVE PHOTOMORPHOGENESIS AND DWARFISM. Steroids 123-130 Cytochrome P450 superfamily protein Arabidopsis thaliana 32-36 10101046-4 1998 At the cellular level, intense to moderate signals for Hsp25 mRNA were localized in the muscle cells of smooth, heart and skeletal types, in the epithelial cells of stratified squamous and transitional types and of the oviduct, in the steroid endocrine cells of the adrenal cortex and corpus luteum, as well as in the spermatocytes of the testis. Steroids 235-242 heat shock protein 1 Mus musculus 55-60 9452971-5 1998 A requisite for the substrate of intestinal P-glycoprotein seemed to be 6 alpha-methyl group in the steroid structure. Steroids 100-107 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 44-58 9452971-6 1998 Substrate specificity of intestinal P-glycoprotein to steroid hormones was shown to be in part different from those in other tissues such as adrenal gland. Steroids 54-70 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 36-50 9585104-0 1998 Effect of human and murine interferon-alpha on steroid production by rat ovarian cells. Steroids 47-54 interferon alpha Mus musculus 27-43 9585104-6 1998 The IFN-alpha obtained from murine leukocytes, also inhibited the response of ovarian cells to the hCG stimulus.The nature of this effect in the secretion of the steroids is dose and time-dependent. Steroids 162-170 interferon alpha Mus musculus 4-13 9802059-5 1998 The cytotoxic effects of DEX in combination with DOX, CDDP, or VP-16 were antagonistic when the steroid was administered 3 h before or simultaneously with the drugs. Steroids 96-103 host cell factor C1 Homo sapiens 63-68 9435603-2 1997 The present study was designed to determine whether exogenous steroid hormones regulate uterine CNP expression in ovariectomized mice. Steroids 62-78 natriuretic peptide type C Mus musculus 96-99 9375770-5 1997 However, the mean SCF concentration in patients who received prednisolone +/- anabolic steroids at the time of sampling was significantly lower than that in the patients who did not receive both agents. Steroids 87-95 KIT ligand Homo sapiens 18-21 9395312-8 1997 Insulin or glucagon respectively repressed or enhanced the dexamethasone-induced accumulation of ASS mRNA when added simultaneously with the steroid for 24 h. This developmental regulation of the ASS mRNA by glucocorticoids, insulin and glucagon could account for the modulation of the enzyme activity previously observed in vivo and in vitro in the foetal liver. Steroids 141-148 argininosuccinate synthase 1 Rattus norvegicus 196-199 9459194-0 1997 Steroid metabolism in the hormone dependent MCF-7 human breast carcinoma cell line and its two hormone resistant subpopulations MCF-7/LCC1 and MCF-7/LCC2. Steroids 0-7 C-C motif chemokine ligand 16 Homo sapiens 134-138 9362267-1 1997 Experiments were designed to determine whether normal fluctuations in sex steroid hormones alter gene transcription for endothelial nitric oxide synthase (NOS) and preproendothelin-1 (prepro-ET-1). Steroids 74-81 endothelin-1 Sus scrofa 164-182 9483579-3 1997 The GR is associated with heat-shock proteins (HSPs) as a functional complex with a high affinity for steroid binding. Steroids 102-109 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 4-6 9295350-0 1997 Steroid-induced conformational changes at ends of the hormone-binding domain in the rat glucocorticoid receptor are independent of agonist versus antagonist activity. Steroids 0-7 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 88-111 9295350-4 1997 Steroid binding did cause a conformational change in the GR that was detected by partial trypsin digestion, as described previously (Simons, S. S., Jr., Sistare, F. D., and Chakraborti, P. K. (1989) J. Biol. Steroids 0-7 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 57-59 9369315-13 1997 In addition, the wide pattern of immunolabeling for Fos in the systematically treated group may reflect both central and peripheral (indirect) steroid effects. Steroids 143-150 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 52-55 9310019-0 1997 Tenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroid. Steroids 92-99 tenascin C Homo sapiens 0-8 9282989-6 1997 These results indicate that the observed increase in steroid production in response to CRH in MA-10 Leydig tumor cells is similar to that previously seen with trophic hormone stimulation acting through the cAMP second messenger pathway, and that it occurs as a result of an increase in the synthesis of the StAR protein. Steroids 53-60 corticotropin releasing hormone Mus musculus 87-90 9376994-3 1997 %CD8 cells were reduced below the normal range in PMR patients prior to steroid therapy. Steroids 72-79 CD8a molecule Homo sapiens 1-4 9376994-4 1997 In 56% of patients, the %CD8 T lymphocytes failed to return to normal levels when quiescent disease allowed cessation of steroid therapy. Steroids 121-128 CD8a molecule Homo sapiens 25-28 9275063-0 1997 Steroid-involved transcriptional regulation of human genes encoding prostatic acid phosphatase, prostate-specific antigen, and prostate-specific glandular kallikrein. Steroids 0-7 acid phosphatase 3 Homo sapiens 68-94 9275063-1 1997 We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Steroids 21-28 acid phosphatase 3 Homo sapiens 64-90 9275063-1 1997 We have compared the steroid regulation of human genes encoding prostatic acid phosphatase (hPAP), prostate-specific antigen (hPSA), and prostate-specific glandular kallikrein (hK2) at the level of transcription. Steroids 21-28 RBPJ pseudogene 3 Homo sapiens 177-180 9275063-7 1997 On the contrary, glucocorticoid stimulation of the transcriptional activity of the hK2 construct was the weakest among the tested steroids. Steroids 130-138 RBPJ pseudogene 3 Homo sapiens 83-86 9275063-8 1997 The results indicate that the steroid response elements in the proximal promoters of hPSA and hK2 genes are not androgen specific, offering the molecular basis for the expression of these genes outside the prostate in tissues containing steroid receptors. Steroids 30-37 RBPJ pseudogene 3 Homo sapiens 94-97 9275068-0 1997 Role of gonadal steroids in determining sexual differences in expression of Fos-related antigens in tyrosine hydroxylase-immunoreactive neurons in subdivisions of the hypothalamic arcuate nucleus. Steroids 16-24 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 76-79 9275068-1 1997 Dual immunohistochemistry was employed to examine the role of gonadal steroids in determining sexual differences in the expression of Fos and its related antigens (FRA) in tuberoinfundibular dopaminergic (TIDA) neurons located in the dorsomedial (DM-) and ventrolateral (VL-) subdivisions of the arcuate nucleus (ARC). Steroids 70-78 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 134-137 9314353-8 1997 SCF that could be immunostained was significantly diminished overall in Np structural cells in the group given in vivo steroid treatment, with a modest (trend to significant) effect on any given cell type analyzed. Steroids 119-126 KIT ligand Homo sapiens 0-3 9314353-11 1997 Our in vitro studies suggest that intranasal steroids blunt SCF expression in Nps, an effect that may be responsible for a decrease in mast cells and symptoms. Steroids 45-53 KIT ligand Homo sapiens 60-63 9379114-1 1997 We have investigated the expression of cholesterol side-chain cleavage cytochrome P450 (P450scc) and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) type 1 genes during human trophoblast differentiation in culture and the modulation of their steady-state mRNA levels by steroids. Steroids 271-279 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 138-148 9379114-8 1997 These observations of the regulation of 3 beta-HSD type 1 mRNA levels by steroids suggest a complex relationship of the mechanisms regulating transcription/mRNA processing and transduction of the 3 beta-HSD type 1 gene. Steroids 73-81 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 40-50 9379114-8 1997 These observations of the regulation of 3 beta-HSD type 1 mRNA levels by steroids suggest a complex relationship of the mechanisms regulating transcription/mRNA processing and transduction of the 3 beta-HSD type 1 gene. Steroids 73-81 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 196-206 9316857-9 1997 Our result is the first finding that a mouse CYP2D enzyme also metabolizes substrates for the rat CYP2D enzyme, in addition to steroids, but the enzyme had a limited specificity for the substrates of the CYP2D enzymes of the rat and the human. Steroids 127-135 cytochrome P450, 2d region Mus musculus 45-50 9316857-9 1997 Our result is the first finding that a mouse CYP2D enzyme also metabolizes substrates for the rat CYP2D enzyme, in addition to steroids, but the enzyme had a limited specificity for the substrates of the CYP2D enzymes of the rat and the human. Steroids 127-135 cytochrome P450, 2d region Mus musculus 98-103 9316857-9 1997 Our result is the first finding that a mouse CYP2D enzyme also metabolizes substrates for the rat CYP2D enzyme, in addition to steroids, but the enzyme had a limited specificity for the substrates of the CYP2D enzymes of the rat and the human. Steroids 127-135 cytochrome P450, 2d region Mus musculus 98-103 9261129-7 1997 We have shown that hsp90, p60, and hsp70 are sufficient for carrying out the folding change that converts the glucocorticoid receptor (GR) hormone binding domain (HBD) from a non-steroid binding to a steroid binding conformation, but to form stable GR.hsp90 heterocomplexes, p23 must also be present in the incubation mix (Dittmar, K. D., and Pratt, W. B. Steroids 179-186 heat shock protein family A (Hsp70) member 4 Homo sapiens 35-40 9252329-6 1997 These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers. Steroids 125-132 ANIB1 Homo sapiens 28-32 9231785-9 1997 Mitogen-stimulated MAP-kinase kinase and MAP-K activities were significantly inhibited by either E or P. The steroids also inhibited mitogen-stimulated c-fos and c-myc, downstream targets for MAP-K action. Steroids 109-117 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 152-157 9205072-9 1997 Our study demonstrates that hK2, a serine protease thought to be found only in prostate-related tissues and fluids, is also produced in a breast cancer cell line T47-D after steroid stimulation. Steroids 174-181 RBPJ pseudogene 3 Homo sapiens 28-31 9261071-4 1997 The determination of the structure of 3 alpha-HSD in complex with NADP+ and testosterone (a competitive inhibitor) will help to further our understanding of steroid recognition and hormone regulation by mammalian HSDs. Steroids 157-164 aldo-keto reductase family 1 member C4 Homo sapiens 38-49 9162006-1 1997 Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown. Steroids 73-80 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 53-64 9162006-1 1997 Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown. Steroids 73-80 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 66-68 9148915-1 1997 The initial hsp90.p60.hsp70-dependent step is sufficient for creating the steroid binding conformation. Steroids 74-81 heat shock protein family A (Hsp70) member 4 Homo sapiens 22-27 9148915-8 1997 In this work we show that when the GR is incubated with hsp90, hsp70, and p60, steroid binding sites are generated despite the absence of p23. Steroids 79-86 heat shock protein family A (Hsp70) member 4 Homo sapiens 63-68 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 heat shock protein family A (Hsp70) member 4 Homo sapiens 37-42 9148915-11 1997 Mixture of purified rabbit hsp90 and hsp70 with bacterial lysate containing human p60 results in spontaneous formation of an hsp90.p60.hsp70 complex that can be adsorbed with anti-p60 antibody, and the resulting immune complex converts the GR HBD to a steroid binding state in an ATP-dependent and K+-dependent manner. Steroids 252-259 heat shock protein family A (Hsp70) member 4 Homo sapiens 135-140 9169006-2 1997 All mono- and dihydroxylated androgens with a hydroxyl function in the 3 alpha, 6 alpha, and 17 beta positions were glucuronidated by UGT2B7, but highest activity was generally observed for steroids containing a 3 alpha-hydroxy substituent. Steroids 190-198 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 134-140 9237422-8 1997 Thus it seems that by replacing C-2 by an oxygen atom we can reduce the biological damage caused by relatively high concentrations of steroid treatment. Steroids 134-141 complement C2 Bos taurus 32-35 9366502-0 1997 Sex and depot-specific stimulation of creatine kinase B in rat adipose tissues by gonadal steroids. Steroids 90-98 creatine kinase B Rattus norvegicus 38-55 9166360-8 1997 Oxytocin and its receptors are regulated by sex steroids and by oxytocin itself. Steroids 48-56 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 9153642-0 1997 Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat. Steroids 34-41 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 95-99 9100567-2 1997 Because gonadotropins induce the growth, differentiation, and function of the steroid-producing cells of the ovary, we hypothesized that mutations in the FSH receptor (FSH-R) might occur in this group of tumors. Steroids 78-85 follicle stimulating hormone receptor Homo sapiens 154-166 9100567-2 1997 Because gonadotropins induce the growth, differentiation, and function of the steroid-producing cells of the ovary, we hypothesized that mutations in the FSH receptor (FSH-R) might occur in this group of tumors. Steroids 78-85 follicle stimulating hormone receptor Homo sapiens 168-173 9131666-0 1997 Gonadal steroid hormone regulation of proopiomelanocortin gene expression in neurons that innervate the median eminence of the rat. Steroids 8-23 proopiomelanocortin Rattus norvegicus 38-57 9131666-1 1997 The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. Steroids 22-29 proopiomelanocortin Rattus norvegicus 60-79 9131666-1 1997 The effect of gonadal steroid hormones on the expression of proopiomelanocortin (POMC) in neurons that innervate the median eminence (ME) was investigated using combined retrograde neuronal labeling and in situ hybridization histochemistry. Steroids 22-29 proopiomelanocortin Rattus norvegicus 81-85 9060803-0 1997 Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients. Steroids 67-74 interleukin 10 Homo sapiens 19-33 9060803-2 1997 We previously demonstrated that pretreatment with steroids can significantly increase IL-10 production during CPB, but neither the heart nor the lung was found to be its main source. Steroids 50-58 interleukin 10 Homo sapiens 86-91 9361803-8 1997 In the prostate of the rat and the dog oxytocin is linked again to steroid metabolism and may also act as a growth regulator. Steroids 67-74 oxytocin/neurophysin I prepropeptide Homo sapiens 39-47 9056058-13 1997 Coprescription of steroids with beta 2-adrenoceptor agonists appeared excessive in 67% patients receiving a beta 2-adrenoceptor agonist, as only 51% had documented evidence of steroid responsiveness or another indication for steroids. Steroids 18-26 adrenoceptor beta 2 Homo sapiens 32-51 9056058-13 1997 Coprescription of steroids with beta 2-adrenoceptor agonists appeared excessive in 67% patients receiving a beta 2-adrenoceptor agonist, as only 51% had documented evidence of steroid responsiveness or another indication for steroids. Steroids 18-26 adrenoceptor beta 2 Homo sapiens 108-127 9056058-13 1997 Coprescription of steroids with beta 2-adrenoceptor agonists appeared excessive in 67% patients receiving a beta 2-adrenoceptor agonist, as only 51% had documented evidence of steroid responsiveness or another indication for steroids. Steroids 18-25 adrenoceptor beta 2 Homo sapiens 108-127 9757695-1 1997 We have studies influence of steroids applied topically (intranasally) in patients with polyps (both operated on and not operated) on the cytology of nasal mucosa in conjunction with the level of serum ECP. Steroids 29-37 ribonuclease A family member 3 Homo sapiens 202-205 9414463-3 1997 This review describes oxytocin pathways in the brain and examines their regulation by gonadal steroids. Steroids 94-102 oxytocin/neurophysin I prepropeptide Homo sapiens 22-30 8940170-0 1996 Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p. Steroids 43-51 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 101-106 8939864-2 1996 The steroid aporeceptor complex contains the molecular chaperones Hsp90 and Hsp70, p48, the cyclophilin Cyp-40, and the associated proteins p23 and p60. Steroids 4-11 heat shock protein family A (Hsp70) member 4 Homo sapiens 76-81 8969273-6 1996 Dexamethasone treatment during culture increased SP-D mRNA and protein about 2-fold with maximal response after 1 to 3 days" exposure to 100 nM steroid; under the same conditions SP-A mRNA content is inhibited. Steroids 144-151 surfactant protein D Homo sapiens 49-53 9001738-0 1996 Differential induction of Fos in the female rat brain following different amounts of vaginocervical stimulation: modulation by steroid hormones. Steroids 127-143 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 26-29 9001738-8 1996 These data demonstrate that cells within different estrogen-concentrating regions of the female rat brain are differentially sensitive to VCS, and that steroid hormones can either increase or decrease the amount of Fos induced by different amounts of VCS. Steroids 152-168 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 215-218 8914992-2 1996 We found that, in the presence of Ca2+, a 10-min exposure of boar spermatozoa to bicarbonate led to a partial activation of phospholipase A2, primed spermatozoa for a major subsequent activation of this enzyme upon stimulation with progesterone and furthermore rendered spermatozoa capable of undergoing exocytosis in response to this steroid. Steroids 335-342 carbonic anhydrase 2 Homo sapiens 34-37 8956025-1 1996 Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. Steroids 53-60 sulfotransferase family 2A member 1 Homo sapiens 32-37 8824338-0 1996 Ovarian steroid regulation of tryptophan hydroxylase mRNA expression in rhesus macaques. Steroids 8-15 tryptophan hydroxylase 1 Macaca mulatta 30-52 8916173-1 1996 The established role of oxytocin (OT) in facilitation of steroid-modulated reproductive and affiliative behaviors led to the speculation that it may have anxiolytic actions under certain hormonal conditions. Steroids 57-64 oxytocin Mus musculus 24-32 8895509-1 1996 The steady state levels of BRCA1 and BRCA2 mRNAs were shown to be coordinately elevated by the steroid hormone estrogen but not progesterone in the human breast cancer cell lines BT-483 and MCF-7. Steroids 95-110 BRCA1 DNA repair associated Homo sapiens 27-32 8895509-1 1996 The steady state levels of BRCA1 and BRCA2 mRNAs were shown to be coordinately elevated by the steroid hormone estrogen but not progesterone in the human breast cancer cell lines BT-483 and MCF-7. Steroids 95-110 BRCA2 DNA repair associated Homo sapiens 37-42 8810273-0 1996 The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. Steroids 105-113 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 38-42 8810273-0 1996 The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo. Steroids 105-113 ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C 47-51 8810273-12 1996 Our data demonstrate that Pdr5 and Snq2 can transport steroid substrates in vivo and suggest that steroids and/or related membrane lipids could represent physiological substrates for certain yeast ABC transporters, which are otherwise involved in the development of pleiotropic drug resistance. Steroids 54-61 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 26-30 8810273-12 1996 Our data demonstrate that Pdr5 and Snq2 can transport steroid substrates in vivo and suggest that steroids and/or related membrane lipids could represent physiological substrates for certain yeast ABC transporters, which are otherwise involved in the development of pleiotropic drug resistance. Steroids 54-61 ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C 35-39 8810273-12 1996 Our data demonstrate that Pdr5 and Snq2 can transport steroid substrates in vivo and suggest that steroids and/or related membrane lipids could represent physiological substrates for certain yeast ABC transporters, which are otherwise involved in the development of pleiotropic drug resistance. Steroids 98-106 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 26-30 8810273-12 1996 Our data demonstrate that Pdr5 and Snq2 can transport steroid substrates in vivo and suggest that steroids and/or related membrane lipids could represent physiological substrates for certain yeast ABC transporters, which are otherwise involved in the development of pleiotropic drug resistance. Steroids 98-106 ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C 35-39 8910257-2 1996 Pyruvate kinase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity significantly increased after treatment of confluent-phase cells with 10 nM 1,25(OH)2D3 for 24 h. Steroid specificity was established by the failure of 10 nM levels of 25-hydroxyvitamin D3 to affect the enzyme activities, while estradiol-17 beta and progesterone produced a slight increase in glucose-6-phosphate dehydrogenase and lactate dehydrogenase levels, respectively. Steroids 184-191 glucose-6-phosphate dehydrogenase Homo sapiens 43-76 8910257-2 1996 Pyruvate kinase, lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity significantly increased after treatment of confluent-phase cells with 10 nM 1,25(OH)2D3 for 24 h. Steroid specificity was established by the failure of 10 nM levels of 25-hydroxyvitamin D3 to affect the enzyme activities, while estradiol-17 beta and progesterone produced a slight increase in glucose-6-phosphate dehydrogenase and lactate dehydrogenase levels, respectively. Steroids 184-191 glucose-6-phosphate dehydrogenase Homo sapiens 379-412 8947831-0 1996 Steroid hormones differentially induce transcription of the chicken ovalbumin gene, but stabilize the mRNA with the same half-life. Steroids 0-16 ovalbumin (SERPINB14) Gallus gallus 68-77 8947831-1 1996 The stabilization of chicken ovalbumin (OVA) mRNA by different classes of steroid hormones (estrogen, progesterone, glucocorticoid, and androgen) was studied in the oviducts of chicks treated with combinations of four steroids. Steroids 74-90 ovalbumin (SERPINB14) Gallus gallus 40-43 9010336-3 1996 The enzyme was found to catalyse preferentially the reduction of steroid substrates using NADPH as an electron donor. Steroids 65-72 2,4-dienoyl-CoA reductase 1 Homo sapiens 90-95 8912998-3 1996 These studies present a variety of conflicting conclusions; meta-analysis indicates a potential benefit of steroids in the reduction of RDS, intraventricular hemorrhage, and mortality. Steroids 107-115 peripherin 2 Homo sapiens 136-139 8756562-2 1996 Peripheral GHR expression is known to be sensitive to gonadal and adrenal steroids, but little is known about their effects on GHR in the central nervous system. Steroids 74-82 growth hormone receptor Rattus norvegicus 11-14 8756562-11 1996 Our results show that GHR expression in the CNS is sensitive to regulation by peripheral steroids but that CNS and hepatic expression of GHR is differentially regulated by the same treatments. Steroids 89-97 growth hormone receptor Rattus norvegicus 22-25 8702813-7 1996 Based on these findings we propose a model in which there is specific, polarity-defined binding of VDR-RXR and RAR-RXR to three half-sites, which form two overlapping steroid response elements, with the central half-site common to both. Steroids 167-174 vitamin D receptor Homo sapiens 99-102 8702813-7 1996 Based on these findings we propose a model in which there is specific, polarity-defined binding of VDR-RXR and RAR-RXR to three half-sites, which form two overlapping steroid response elements, with the central half-site common to both. Steroids 167-174 retinoid X receptor alpha Homo sapiens 103-106 8702813-7 1996 Based on these findings we propose a model in which there is specific, polarity-defined binding of VDR-RXR and RAR-RXR to three half-sites, which form two overlapping steroid response elements, with the central half-site common to both. Steroids 167-174 retinoid X receptor alpha Homo sapiens 115-118 8866005-1 1996 This study was directed at achieving an understanding of the mechanisms by which steroid hormones control the synthesis of vitellogenin (VTG) protein in the liver of the Japanese quail. Steroids 81-97 vitellogenin-2 Coturnix japonica 123-135 8866005-1 1996 This study was directed at achieving an understanding of the mechanisms by which steroid hormones control the synthesis of vitellogenin (VTG) protein in the liver of the Japanese quail. Steroids 81-97 vitellogenin-2 Coturnix japonica 137-140 8866250-6 1996 Moreover, Fos immunostaining was visible throughout steroid-responsive limbic regions in all three groups of lambs. Steroids 52-59 protein c-Fos Ovis aries 10-13 8918981-0 1996 Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. Steroids 43-51 translocator protein Rattus norvegicus 61-95 8918981-0 1996 Direct interactions of androgenic/anabolic steroids with the peripheral benzodiazepine receptor in rat brain: implications for the psychological and physiological manifestations of androgenic/anabolic steroid abuse. Steroids 43-50 translocator protein Rattus norvegicus 61-95 8918981-1 1996 The peripheral benzodiazepine receptor (PBR) is a mitochondrial protein involved in regulating steroid synthesis and transport. Steroids 95-102 translocator protein Rattus norvegicus 4-38 8918981-1 1996 The peripheral benzodiazepine receptor (PBR) is a mitochondrial protein involved in regulating steroid synthesis and transport. Steroids 95-102 translocator protein Rattus norvegicus 40-43 8918981-2 1996 We report here the effects of androgenic/anabolic steroids (AAS) on the binding of the PBR-specific ligand [3H] PK11195 to male rat brain cortical synaptoneurosomes. Steroids 50-58 translocator protein Rattus norvegicus 87-90 8694565-2 1996 This could be due to the anti-mitogenic effect of the steroid hormone on human colon carcinoma cells which is mediated by a specific nuclear vitamin D receptor (VDR). Steroids 54-69 vitamin D receptor Homo sapiens 141-159 8694565-2 1996 This could be due to the anti-mitogenic effect of the steroid hormone on human colon carcinoma cells which is mediated by a specific nuclear vitamin D receptor (VDR). Steroids 54-69 vitamin D receptor Homo sapiens 161-164 8762079-16 1996 By contrast, relatively high concentrations (3-10 microM) of this steroid had only a modest effect on the Rdl receptor and its splice variant. Steroids 66-73 LEO1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 106-109 21153282-1 1996 Steroidogenic acute regulatory (StAR) protein is thought to mediate the rapid increase in steroid hormone biosynthesis in response to tropic hormones by facilitating cholesterol transport to the inner mitochondrial membrane where the P450 side-chain cleavage enzyme (P450scc) is located. Steroids 90-105 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 234-265 21153282-1 1996 Steroidogenic acute regulatory (StAR) protein is thought to mediate the rapid increase in steroid hormone biosynthesis in response to tropic hormones by facilitating cholesterol transport to the inner mitochondrial membrane where the P450 side-chain cleavage enzyme (P450scc) is located. Steroids 90-105 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 267-274 8752659-7 1996 Vitamin D receptor protein associates with Shc, indicating that this steroid hormone is able to signal through the transcription-independent pathways similar to those used by peptide hormones and cytokines. Steroids 69-84 vitamin D receptor Homo sapiens 0-18 8752659-7 1996 Vitamin D receptor protein associates with Shc, indicating that this steroid hormone is able to signal through the transcription-independent pathways similar to those used by peptide hormones and cytokines. Steroids 69-84 SHC adaptor protein 1 Homo sapiens 43-46 8813574-3 1996 Based on our previous findings that the 3 alpha-hydroxy ring A-reduced pregnane steroids allotetrahydroprogesterone and allotetrahydrodeoxycorticosterone may regulate gene expression via the progesterone receptor after intracellular oxidation, we have characterized the effects of a series of natural and synthetic neuroactive steroids at the genomic level using a cotransfection system with various steroid receptor expression vectors and a reporter gene in a human neuroblastoma cell line. Steroids 80-88 progesterone receptor Gallus gallus 191-212 8621511-0 1996 Modulation of cytosolic protein kinase C and calcium ion activity by steroid hormones in rat distal colon. Steroids 69-85 protein kinase C, gamma Rattus norvegicus 24-40 8638930-1 1996 DLIF (digoxin-like immunoreactive factor) and OLF (ouabain-like factor) are endogenous steroid-like ligands (approximately 781 and 595 Da, respectively) with molecular and structural properties similar to the plant-derived cardiac glycosides, digoxin and ouabain. Steroids 87-94 transmembrane O-mannosyltransferase targeting cadherins 1 Homo sapiens 46-49 8901111-0 1996 Steroid hormone-induced expression of the chicken ovalbumin gene and the levels of nuclear steroid hormone receptors in chick oviduct. Steroids 0-15 ovalbumin (SERPINB14) Gallus gallus 50-59 8901111-1 1996 The induction of the chicken ovalbumin (OVA) gene by different classes of steroid hormones and the mRNA levels of estrogen (ER), progesterone (PR), and glucocorticoid (GR) receptors were studied in chick oviducts. Steroids 74-90 ovalbumin (SERPINB14) Gallus gallus 29-38 8901111-1 1996 The induction of the chicken ovalbumin (OVA) gene by different classes of steroid hormones and the mRNA levels of estrogen (ER), progesterone (PR), and glucocorticoid (GR) receptors were studied in chick oviducts. Steroids 74-90 ovalbumin (SERPINB14) Gallus gallus 40-43 8838016-0 1996 Ovarian steroid hormones regulate granulocyte-macrophage colony-stimulating factor synthesis by uterine epithelial cells in the mouse. Steroids 8-24 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 34-82 8838016-8 1996 Analysis of GM-CSF mRNA expression in uterine epithelial cell cultures and in intact uteri from steroid hormone-treated ovariectomized mice by quantitative reverse transcription-polymerase chain reaction indicated that the effects of estrogen and progesterone on GM-CSF release are mediated at least in part at the transcriptional level. Steroids 96-111 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 12-18 8838016-9 1996 These findings implicate GM-CSF as a local mediator of steroid-driven remodeling events in the cycling and preimplantation endometrium, possibly acting through the recruitment and behavioral regulation of granulocytes and macrophages. Steroids 55-62 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 25-31 8848456-4 1996 Neuroactive steroids (listed from greatest to least efficacious at GABAA receptor complexes) were THP [5 alpha-pregnan-3 alpha-ol-20-one], THDOC [5 alpha-pregnan-3 alpha, 21-diol-20-one], DHP [5 alpha-pregnan-3,20-dione], P [4-pregnen-3,20-dione], and DHEAS [5-androsten-3 beta-ol-17-one sulfate]. Steroids 12-20 dihydropyrimidinase Rattus norvegicus 188-191 8597466-1 1995 The hypothesis has been advanced that the adrenal steroids dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert antiatherogenic and cardioprotective actions. Steroids 50-58 sulfotransferase family 2A member 1 Homo sapiens 107-112 8530400-2 1995 Transcriptional activation of a GAL4 luciferase reporter vector up to 100-fold was greater than Fos/Jun leucine zipper binding, indicating stable AR interaction between AR NH2-terminal residues 1-503 and steroid-binding domain residues 624-919 that was specific for and dependent on androgen binding to the steroid-binding domain and was inhibited by anti-androgen binding. Steroids 204-211 galectin 4 Homo sapiens 32-36 8530400-2 1995 Transcriptional activation of a GAL4 luciferase reporter vector up to 100-fold was greater than Fos/Jun leucine zipper binding, indicating stable AR interaction between AR NH2-terminal residues 1-503 and steroid-binding domain residues 624-919 that was specific for and dependent on androgen binding to the steroid-binding domain and was inhibited by anti-androgen binding. Steroids 307-314 galectin 4 Homo sapiens 32-36 7500041-0 1995 Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid-resistant asthma. Steroids 68-75 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 33-52 7500041-6 1995 To study this reduced DNA binding, we examined the ability of the nuclear translocated transcription factors activator protein 1 (AP-1), nuclear factor kappa B (NF-kappa B) and cyclic AMP response element-binding protein (CREB) to bind to their DNA-binding sites and to interact with GR in PBMC from patients with steroid-sensitive and steroid-resistant asthma. Steroids 314-321 cAMP responsive element binding protein 1 Homo sapiens 222-226 7500041-6 1995 To study this reduced DNA binding, we examined the ability of the nuclear translocated transcription factors activator protein 1 (AP-1), nuclear factor kappa B (NF-kappa B) and cyclic AMP response element-binding protein (CREB) to bind to their DNA-binding sites and to interact with GR in PBMC from patients with steroid-sensitive and steroid-resistant asthma. Steroids 336-343 cAMP responsive element binding protein 1 Homo sapiens 222-226 7500041-7 1995 There was a significant reduction in the interaction between GR and AP-1 in these steroid-resistant patients, although interaction with other transcription factors activated in inflammation (NF-kappa B and CREB) was unaffected. Steroids 82-89 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 68-72 7500041-8 1995 An increase in the basal levels of AP-1 DNA binding was also detected in the nuclei from steroid-resistant asthmatic patients. Steroids 89-96 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 35-39 7500041-10 1995 These results suggest either that the ability of the GR to bind to glucocorticoid response elements and AP-1 is altered in steroid-resistant patients or that increased levels of AP-1 prevent GR DNA binding, and that this may be the molecular basis of resistance to the antiinflammatory effect of steroids in these cells. Steroids 123-130 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 104-108 7500041-10 1995 These results suggest either that the ability of the GR to bind to glucocorticoid response elements and AP-1 is altered in steroid-resistant patients or that increased levels of AP-1 prevent GR DNA binding, and that this may be the molecular basis of resistance to the antiinflammatory effect of steroids in these cells. Steroids 296-304 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 178-182 7591291-0 1995 Regulation of EGF-induced tenascin-C by steroids in tenascin-C-non-producing human carcinoma cells. Steroids 40-48 tenascin C Homo sapiens 52-62 7591291-5 1995 We show that steroid hormones down-regulate EGF-induced tenascin-C glycoprotein and its mRNA in these tenascin-C-non-producing carcinoma cells. Steroids 13-20 tenascin C Homo sapiens 56-66 7591291-5 1995 We show that steroid hormones down-regulate EGF-induced tenascin-C glycoprotein and its mRNA in these tenascin-C-non-producing carcinoma cells. Steroids 13-20 tenascin C Homo sapiens 102-112 7591291-6 1995 Of the steroids examined, hydrocortisone most effectively inhibited the secretion of tenascin-C. Steroids 7-15 tenascin C Homo sapiens 85-95 7591291-8 1995 Our results indicate that the induction of tenascin-C by EGF and its down-regulation by steroids might proceed in these carcinoma cells through separate signal transduction pathways. Steroids 88-96 tenascin C Homo sapiens 43-53 7584154-5 1995 These results suggest that glucocorticoids are necessary for survival and maturation of thymocytes, and are consistent with a role for steroids in both the transition from CD4-CD8- to CD4+CD8+ cells and the survival of CD4+CD8+ cells stimulated via the TCR. Steroids 135-143 CD4 antigen Mus musculus 172-175 7584154-5 1995 These results suggest that glucocorticoids are necessary for survival and maturation of thymocytes, and are consistent with a role for steroids in both the transition from CD4-CD8- to CD4+CD8+ cells and the survival of CD4+CD8+ cells stimulated via the TCR. Steroids 135-143 CD4 antigen Mus musculus 184-187 7584154-5 1995 These results suggest that glucocorticoids are necessary for survival and maturation of thymocytes, and are consistent with a role for steroids in both the transition from CD4-CD8- to CD4+CD8+ cells and the survival of CD4+CD8+ cells stimulated via the TCR. Steroids 135-143 CD4 antigen Mus musculus 184-187 8571606-5 1995 Although anti-platelet antibodies weren"t isolated in the serum, the patient"s response to steroids and its similarity to other cases with evidence of carcinoma-related immune-mediated platelet destruction makes this process most likely in the case presented. Steroids 91-99 derlin 2 Homo sapiens 151-168 7553629-1 1995 BRCA1 mRNA and protein levels are regulated by the steroid hormones estrogen and progesterone in human breast cancer cells. Steroids 51-67 BRCA1 DNA repair associated Homo sapiens 0-5 7553629-4 1995 T47-D cells deprived of steroid hormones and subsequently stimulated with progesterone also showed a delayed increase in BRCA1 mRNA expression. Steroids 24-40 BRCA1 DNA repair associated Homo sapiens 121-126 7553629-6 1995 When considered together, the data suggest that steroid hormones may affect BRCA1 expression indirectly by altering the proliferative status of the cells rather than acting directly on DNA sequences in the BRCA1 gene itself. Steroids 48-64 BRCA1 DNA repair associated Homo sapiens 76-81 7553629-6 1995 When considered together, the data suggest that steroid hormones may affect BRCA1 expression indirectly by altering the proliferative status of the cells rather than acting directly on DNA sequences in the BRCA1 gene itself. Steroids 48-64 BRCA1 DNA repair associated Homo sapiens 206-211 8522067-7 1995 after passaging), KiGLOM cells expressed the steroid-specific cholesterol side chain cleavage cytochrome P-450scc and they produced significant, albeit reduced, amounts of corticosterone in comparison with primary GLOM cultures. Steroids 45-52 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 105-113 7490009-8 1995 In tissues stained rapidly in diaminobenzidine, androgen receptor-containing neurons were visible only in steroid responsive brain regions adjacent to the testosterone implant. Steroids 106-113 androgen receptor Mesocricetus auratus 48-65 8557238-3 1995 We therefore tested the in vivo effect of both steroids on PTHrP secretion and tumor development of the Walker carcinoma (WC). Steroids 47-55 parathyroid hormone-like hormone Rattus norvegicus 59-64 7577705-1 1995 Autoregulation of glucocorticoid receptor (GR) concentration in vivo may be an important determinant of steroid sensitivity. Steroids 104-111 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 18-41 7577705-1 1995 Autoregulation of glucocorticoid receptor (GR) concentration in vivo may be an important determinant of steroid sensitivity. Steroids 104-111 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 43-45 7491104-2 1995 Two major regulatory elements reside in the chicken ovalbumin gene, a steroid-dependent regulatory element (SDRE, -892 to -780) and a negative regulatory element (NRE, -308 to -88). Steroids 70-77 ovalbumin (SERPINB14) Gallus gallus 52-61 7657391-1 1995 The nuclear transcription factor Fos is inducible by both steroid hormones and peptide growth factors. Steroids 58-74 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 33-36 7664341-6 1995 Thus, steroid-induced proliferation of mammary epithelium during pregnancy may be driven through cyclin D1. Steroids 6-13 cyclin D1 Mus musculus 97-106 7492675-14 1995 When PAF was administered to adult female rats pretreated with sex steroid hormones, the mortality of rats with low plasma PAF-AH activity caused by 17 alpha-ethynylestradiol was increased but that of rats with high PAF-AH activity caused by medroxyprogesterone was decreased. Steroids 67-83 PCNA clamp associated factor Rattus norvegicus 5-8 7492675-14 1995 When PAF was administered to adult female rats pretreated with sex steroid hormones, the mortality of rats with low plasma PAF-AH activity caused by 17 alpha-ethynylestradiol was increased but that of rats with high PAF-AH activity caused by medroxyprogesterone was decreased. Steroids 67-83 PCNA clamp associated factor Rattus norvegicus 123-126 7492675-14 1995 When PAF was administered to adult female rats pretreated with sex steroid hormones, the mortality of rats with low plasma PAF-AH activity caused by 17 alpha-ethynylestradiol was increased but that of rats with high PAF-AH activity caused by medroxyprogesterone was decreased. Steroids 67-83 PCNA clamp associated factor Rattus norvegicus 123-126 7492682-2 1995 Expression of mRNA for TIMP-1 and TIMP-2 was examined by Northern analysis of endometrial RNA derived from steroid-treated ovariectomized ewes and from intact ewes during the estrous cycle and early pregnancy. Steroids 107-114 TIMP metallopeptidase inhibitor 2 Homo sapiens 34-40 7561643-1 1995 An experiment was conducted to determine the effects of epidermal growth factor (EGF) and fibroblast growth factor (FGF), infused into the ovarian artery, on the secretion of ovarian steroids during the mid-luteal phase in ewes with an autotransplanted ovary. Steroids 183-191 EGF Ovis aries 56-79 7561643-1 1995 An experiment was conducted to determine the effects of epidermal growth factor (EGF) and fibroblast growth factor (FGF), infused into the ovarian artery, on the secretion of ovarian steroids during the mid-luteal phase in ewes with an autotransplanted ovary. Steroids 183-191 EGF Ovis aries 81-84 7616206-1 1995 In examining steroid synthesis in the CNS, expression of the mRNAs encoding for cytochrome P450 side-chain cleavage enzyme (P450scc) and 3 beta-hydroxy-steroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) has been studied in the rat brain. Steroids 13-20 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 80-122 7662588-2 1995 Regulation of VDR is under the influence of several factors which include the functional ligand for this receptor (1,25(OH)2-vitamin D3) as well as heterologous steroid hormones. Steroids 161-177 vitamin D receptor Homo sapiens 14-17 7476024-5 1995 An increase in neurotrophin expression is therefore not a general response to steroid hormone application, and may be a specific defence against the presence of metabolically endangering glucocorticoids. Steroids 78-93 brain derived neurotrophic factor Homo sapiens 15-27 7580937-0 1995 Synthetic peptides derived from the steroid binding domain block modulator and molybdate action toward the rat glucocorticoid receptor. Steroids 36-43 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 111-134 7794283-0 1995 Adrenocortical steroids, thyroid hormones and retinoic acid augment the production of adrenomedullin in vascular smooth muscle cells. Steroids 15-23 adrenomedullin Rattus norvegicus 86-100 7626445-1 1995 The enzyme 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) catalyses an essential step in the biosynthesis of all classes of steroid hormones. Steroids 126-142 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 48-58 7772604-2 1995 CSAD activity and enzyme protein concentration are both repressed by the action of the steroid family hormones triiodothyronine and estrogen. Steroids 87-94 cysteine sulfinic acid decarboxylase Rattus norvegicus 0-4 7720680-12 1995 Further, at the time point studied, E2 replacement is more effective in maintaining BDNF mRNA in the hippocampus than in the cortex, suggesting a regional difference in the ovarian steroid requirement for expression of BDNF. Steroids 181-188 brain-derived neurotrophic factor Rattus norvegicus 219-223 7726568-0 1995 On the mechanism of interaction of steroids with human glucose 6-phosphate dehydrogenase. Steroids 35-43 glucose-6-phosphate dehydrogenase Homo sapiens 55-88 7726568-3 1995 In order to elucidate the detailed mechanism of this rare type of inhibition, we examined the effects of steroids on human glucose 6-phosphate dehydrogenase catalyzing the reverse reaction, i.e., the reduction of the gluconolactone by NADPH. Steroids 105-113 glucose-6-phosphate dehydrogenase Homo sapiens 123-156 7726568-7 1995 These results demonstrate that steroids inhibit glucose 6-phosphate dehydrogenase by binding to the ternary enzyme-coenzyme-substrate ternary complex(es). Steroids 31-39 glucose-6-phosphate dehydrogenase Homo sapiens 48-81 7663533-8 1995 Interestingly, the nonsteroidogenic lung fibroblast derived V79 Chinese hamster cell line was able to support human CYP11B1 mediated steroid hydroxylation without simultaneous heterologous expression of the human electron transfer system, adrenodoxin, and adrenodoxin reductase. Steroids 22-29 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 116-123 7620833-1 1995 beta-Glucuronidase cleaves beta-glucuronides of drugs, steroids, as well as macromolecular compounds containing glucuronic acid bound with a beta-glycoside bond. Steroids 55-63 glucuronidase, beta Rattus norvegicus 0-18 7893157-0 1995 Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence. Steroids 94-101 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 67-74 7836919-1 1995 Using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) to detect cells undergoing early apoptosis, we have defined the surface markers expressed on CD4+CD8+ thymocytes undergoing spontaneous or steroid-induced apoptosis in tissue culture. Steroids 230-237 CD8a molecule Homo sapiens 188-191 8575269-6 1995 Elastin expression is modulated by peptide growth factors, steroid hormones and phorbol esters, among which transforming growth factor beta (TGF-beta) is an especially potent up-regulator, acting largely through stabilization of mRNA. Steroids 59-75 elastin Homo sapiens 0-7 7758243-4 1995 We have examined the ability of steroids to influence ovarian N-cad mRNA levels in vivo. Steroids 32-40 cadherin 2 Mus musculus 62-67 7758243-7 1995 We speculate that this steroid is a major regulator of N-cad-mediated granulosa cell interactions in vivo. Steroids 23-30 cadherin 2 Mus musculus 55-60 8586300-7 1995 More research is needed to clarify the role of oxytocin in human reproductive behaviors, including its potential "aphrodisiac" or prosexual effect in women in the presence of the sex-steroid hormones. Steroids 183-190 oxytocin/neurophysin I prepropeptide Homo sapiens 47-55 7955120-1 1994 Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Steroids 68-75 sulfotransferase family 2A member 1 Homo sapiens 32-37 7956914-1 1994 Adrenal steroids exert their effects through two distinct adrenal steroid receptor subtypes; the high affinity type I, or mineralocorticoid, receptor and the lower affinity type II, or glucocorticoid, receptor. Steroids 8-16 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 111-209 7894629-4 1994 The symptom-free children with inhaled steroids had similar median ECP and MPO values as the controls, 8.0 and 360 micrograms/l, vs. 9.0 and 310 micrograms/l, while both ECP and MPO were significantly (p < 0.001) increased in the symptom-free children without anti-inflammatory treatment, 32 and 887 micrograms/l and in those with acute asthma, 28 and 860 micrograms/l. Steroids 39-47 ribonuclease A family member 3 Homo sapiens 67-70 7894629-4 1994 The symptom-free children with inhaled steroids had similar median ECP and MPO values as the controls, 8.0 and 360 micrograms/l, vs. 9.0 and 310 micrograms/l, while both ECP and MPO were significantly (p < 0.001) increased in the symptom-free children without anti-inflammatory treatment, 32 and 887 micrograms/l and in those with acute asthma, 28 and 860 micrograms/l. Steroids 39-47 ribonuclease A family member 3 Homo sapiens 170-173 7894629-9 1994 The normal levels of ECP and MPO in the children with asthma using inhaled steroids seem to reflect successful anti-inflammatory treatment. Steroids 75-83 ribonuclease A family member 3 Homo sapiens 21-24 7980630-3 1994 Pre-treatment of rats with the glucocorticoid receptor antagonist RU38486 (20 mg/kg) prevented the steroid induction of extracellular LC1 at both the 3 and 6 hr time-points. Steroids 99-106 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 31-54 7964312-13 1994 We conclude that direct arterial infusion of TGF alpha results in acute inhibition of ovarian steroid and inhibin secretion that is associated with induction of atresia in the population of large follicles. Steroids 94-101 transforming growth factor alpha Rattus norvegicus 45-54 7849266-5 1994 Transcriptional activation of c-fos, c-myc and cyclin D1 by estrogens and progestins in breast cancer cells and inhibition of expression of these genes by antiestrogens provide a paradigm for further understanding cell cycle control by steroids. Steroids 236-244 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 30-35 7918108-0 1994 Dimerization characteristics of the DNA- and steroid-binding domains of the androgen receptor. Steroids 45-52 androgen receptor Rattus norvegicus 76-93 7969784-2 1994 The endogenous steroid hormone CT has tenfold higher affinity for the MR than the GR. Steroids 15-30 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 82-84 8068673-0 1994 Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase. Steroids 85-100 aldo-keto reductase family 1, member C14 Rattus norvegicus 116-152 8060996-1 1994 The rat CYP2C13 gene (2C13) encodes one of the constitutive male forms of cytochrome P-450 that are involved in steroid metabolism. Steroids 112-119 cytochrome P450, family 2, subfamily c, polypeptide 13 Rattus norvegicus 8-15 7978646-10 1994 The association of haptoglobin with hepatic lipidosis can be reasonably explained by the fact that haptoglobin production by the liver is induced by glucocorticoids and estradiol, and these steroid hormones are triggers for development of hepatic lipidosis in cattle. Steroids 190-206 haptoglobin Bos taurus 19-30 7978646-10 1994 The association of haptoglobin with hepatic lipidosis can be reasonably explained by the fact that haptoglobin production by the liver is induced by glucocorticoids and estradiol, and these steroid hormones are triggers for development of hepatic lipidosis in cattle. Steroids 190-206 haptoglobin Bos taurus 99-110 8007953-1 1994 The transcription of the Drosophila melanogaster Fbp1 gene is induced by the steroid hormone 20-hydroxyecdysone and restricted to the late-third-instar fat body tissue. Steroids 77-92 Fat body protein 1 Drosophila melanogaster 49-53 8080909-7 1994 Steroid hormone treatment of ovariectomized female baboons confirmed that both transcription and translation of uterine RBP is under progestational control. Steroids 0-15 retinol binding protein 4 Sus scrofa 120-123 8033249-2 1994 DHEA ST catalyzes the sulfation of DHEA and other steroids. Steroids 50-58 sulfotransferase family 2A member 1 Homo sapiens 0-7 7520304-12 1994 Unpublished studies suggest that the steroids prednisolone and dexamethasone can synergize in vitro with suboptimal concentrations of interferon-gamma (IFN-gamma) to promote the activation of human endothelial cell lines, as manifested by enhanced expression of MHC class II but not ICAM-1. Steroids 37-45 intercellular adhesion molecule 1 Homo sapiens 283-289 8088295-1 1994 In a girl aged 5 years with a virilizing adrenal adenoma the urinary and plasma steroid findings suggested the diagnosis of congenital adrenal hyperplasia due to P450c11 (11 beta-hydroxylase) deficiency. Steroids 80-87 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 162-169 8088295-3 1994 RNA analysis of the tumour tissue revealed low amounts of P450c11 mRNA which indicates that P450c11 deficiency of the adenoma caused the steroid abnormalities in this girl. Steroids 137-144 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 92-99 8175784-4 1994 Cys-170, Cys-242, and Cys-217, implicated by bromoacetoxysteroid affinity-labeling agents as points of contact for the C-3, C-11, and C-17 positions of steroid ligands, were mutated to alanines. Steroids 57-64 complement C3 Rattus norvegicus 119-122 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Steroids 194-210 adrenoceptor beta 2 Homo sapiens 79-88 8049696-4 1994 All these mechanisms are involved in homologous and heterologous regulation of beta 2-AR, which accounts for the modulation of beta 2-AR synthesis and responsiveness mediated by catecholamines, steroid hormones, inflammatory mediators and other agents. Steroids 194-210 adrenoceptor beta 2 Homo sapiens 127-136 8052998-0 1994 Effects of steroids on association of T-2 toxin with mammalian cells. Steroids 11-19 solute carrier family 25 member 5 Homo sapiens 38-41 8052998-1 1994 The effects of steroids on the association of T-2 toxin with cultured cells were evaluated. Steroids 15-23 solute carrier family 25 member 5 Homo sapiens 46-49 8052998-2 1994 Preincubating cells with certain steroids led to a time- and concentration-related increase in total T-2-cell association. Steroids 33-41 solute carrier family 25 member 5 Homo sapiens 101-104 11607466-8 1994 The results also are consistent with placement of the HMGR activities encoded by hmg1 and hmg2 within discrete steroid and sesquiterpenoid biosynthetic channels. Steroids 111-118 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 Solanum tuberosum 90-94 8166236-0 1994 Mineralocorticoid and glucocorticoid receptor steroid binding and localization in colonic cells. Steroids 46-53 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 22-45 8126127-1 1994 Three beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) deficiency is a form of congenital adrenal hyperplasia characterized by severe impairment of steroid biosynthesis in the adrenals and gonads. Steroids 18-25 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-77 8106362-3 1994 Although the total amount of PKC alpha, PKC beta, and PKC zeta are unaffected by 1,25-(OH)2-D3, this steroid hormone induces subcellular redistribution of both PKC alpha and PKC beta. Steroids 101-116 protein kinase C alpha Bos taurus 29-38 8106362-3 1994 Although the total amount of PKC alpha, PKC beta, and PKC zeta are unaffected by 1,25-(OH)2-D3, this steroid hormone induces subcellular redistribution of both PKC alpha and PKC beta. Steroids 101-116 protein kinase C alpha Bos taurus 160-169 8299591-9 1994 In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile acids and cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of a number of biologically active and potentially toxic steroids in the developing human. Steroids 72-80 sulfotransferase family 2A member 1 Homo sapiens 208-215 8299591-9 1994 In light of the broad substrate specificity of this enzyme toward other steroids, in particular bile acids and cholesterol, the information presented forms a strong basis for further studies into the role of DHEA ST in modulating the activity of a number of biologically active and potentially toxic steroids in the developing human. Steroids 300-308 sulfotransferase family 2A member 1 Homo sapiens 208-215 7538605-0 1994 Modulation of ionic currents through GABAA receptor subtypes by endogenous steroids. Steroids 75-83 gamma-aminobutyric acid type A receptor gamma3 subunit Gallus gallus 37-51 8201845-0 1994 Modulation of peripheral benzodiazepine receptors in female rat genital organs by various gonadal steroids. Steroids 98-106 translocator protein Rattus norvegicus 14-49 8201845-9 1994 Taken together, it is suggested that PBR density in the ovary is altered by exogenously administered steroids that usually are biosynthesized in the ovary. Steroids 101-109 translocator protein Rattus norvegicus 37-40 8201845-10 1994 Additionally, the altered PBR density in the oviduct and uterus via the various steroids employed may imply that changes occurring in ovarian steroidogenesis should affect PBR density in these organs. Steroids 80-88 translocator protein Rattus norvegicus 26-29 8201845-10 1994 Additionally, the altered PBR density in the oviduct and uterus via the various steroids employed may imply that changes occurring in ovarian steroidogenesis should affect PBR density in these organs. Steroids 80-88 translocator protein Rattus norvegicus 172-175 7830855-10 1994 In the steroid-resistant patients, the only significant changes observed were decreased fibrinogen and increased protein C. Steroids 7-14 proline rich protein HaeIII subfamily 1 Homo sapiens 113-122 8130767-1 1993 The gene structure of bovine adrenodoxin reductase, a component of the mitochondrial steroid hydroxylating system in the adrenal cortex, was determined. Steroids 85-92 ferredoxin reductase Bos taurus 29-50 8243263-9 1993 Hepatic levels of GHBP-, and GH receptor mRNA transcripts showed the same trends in response to steroid or GH treatment, but the differences were rarely significant, except in Ovx animals which had higher GHBP mRNA transcripts after GH or E2 treatment. Steroids 96-103 growth hormone receptor Homo sapiens 18-22 8243263-9 1993 Hepatic levels of GHBP-, and GH receptor mRNA transcripts showed the same trends in response to steroid or GH treatment, but the differences were rarely significant, except in Ovx animals which had higher GHBP mRNA transcripts after GH or E2 treatment. Steroids 96-103 growth hormone receptor Rattus norvegicus 29-40 8680446-14 1993 This data shows that both POMC and PPE mRNA levels are altered in the sheep brain during pregnancy, parturition and lactation and in response to sex steroids, although the direction of the changes is not always the same and in the case of PPE only the VMN and PVN are affected. Steroids 149-157 pro-opiomelanocortin Ovis aries 26-30 8155577-1 1993 Transcription of the D. melanogaster Fat-body-protein-1 (Fbp1) gene is induced by the steroid hormone 20-hydroxyecdysone and is restricted to the fat body tissue at the end of the third larval instar. Steroids 86-101 Fat body protein 1 Drosophila melanogaster 37-55 8155577-1 1993 Transcription of the D. melanogaster Fat-body-protein-1 (Fbp1) gene is induced by the steroid hormone 20-hydroxyecdysone and is restricted to the fat body tissue at the end of the third larval instar. Steroids 86-101 Fat body protein 1 Drosophila melanogaster 57-61 8222492-1 1993 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfation of steroid hormones such as DHEA, estrone, and estradiol. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 0-39 8222492-1 1993 Dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfation of steroid hormones such as DHEA, estrone, and estradiol. Steroids 77-93 sulfotransferase family 2A member 1 Homo sapiens 41-48 8222492-8 1993 The existence of a subgroup of subjects with a high level of DHEA ST enzymatic activity in liver and a 4.6-fold range in this activity have implications for individual differences in the sulfate conjugation of endogenous and exogenously administered steroid hormones and raise the possibility of pharmacogenetic regulation of this important enzyme in humans. Steroids 250-266 sulfotransferase family 2A member 1 Homo sapiens 61-68 8227185-9 1993 Furthermore, the steroid increased steady-state IL-4R mRNA levels in both a time- and concentration-dependent manner. Steroids 17-24 interleukin 4 receptor, alpha Mus musculus 48-53 7689953-5 1993 In HFCM from cells treated with vehicle, GH, insulin, epidermal growth factor, steroid hormones, or forskolin, IGF-II induced the select loss of detectable IGFBP-4 during the assay. Steroids 79-95 insulin like growth factor binding protein 4 Homo sapiens 156-163 8253061-0 1993 Effect of steroids on the synthesis of complement C3 in a human alveolar epithelial cell line. Steroids 10-18 complement C3 Homo sapiens 39-52 9831476-4 1993 Northern blot analysis of uterine RNA revealed that induction of jun-D was specific for estrogenic steroids, as progesterone and testosterone had no effect on expression of this member of the jun gene family. Steroids 99-107 JunD proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 65-70 8338786-1 1993 20 beta-Hydroxysteroid dehydrogenase from the cytosolic fraction of neonatal pig testis is a NADPH-dependent enzyme that catalyzes the reduction of the C-20 ketone of C21-steroids. Steroids 171-179 carbonyl reductase [NADPH] 1 Sus scrofa 0-36 7686046-3 1993 Dose response and steroid specificity experiments showed that the hKLK2 promoter confers androgen receptor-mediated gene induction in a ligand-specific manner. Steroids 18-25 kallikrein related peptidase 2 Homo sapiens 66-71 8366134-6 1993 This observation, combined with the presence of high-affinity 3H-1,25 (OH)2 D3 receptors (88 sites/cell, K = 0.45 nM) in cytosolic extracts, strongly suggests that the nuclear vitamin D receptor mediates this steroid"s effect on interleukin 1 receptor expression. Steroids 209-216 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 176-194 8518207-1 1993 3 beta-Hydroxysteroid dehydrogenase (3 beta-HSD)/delta 5-->4-isomerase activity in steroidogenic tissues is required for the synthesis of biologically active steroids. Steroids 161-169 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 37-47 7683699-8 1993 Using in situ hybridization, we show that VEGF is expressed in 10 different steroidogenic and/or steroid-responsive cell types (theca, cumulus, granulosa, lutein, oviductal epithelium, endometrial stroma, decidua, giant trophoblast cells, adrenal cortex, and Leydig cells). Steroids 76-83 vascular endothelial growth factor A Mus musculus 42-46 8455948-1 1993 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes that encode nuclear receptors for various hydrophobic ligands such as steroids, retinoic acid and thyroid hormones. Steroids 158-166 thyroid hormone receptor alpha Homo sapiens 44-52 8382211-2 1993 It was found that GST gene expression was induced in steroid-sensitive cells within 4 hr of dexamethasone treatment, required functional glucocorticoid receptor, and was dose-dependent with regard to hormone. Steroids 53-60 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 137-160 8431420-8 1993 Because aldose reductase has been implicated in the etiology of diabetic complications, acceptance of steroid substrates may offer new implications for therapy. Steroids 102-109 aldose reductase Bos taurus 8-24 7916682-10 1993 Therefore, CBG present in the placenta is most likely of maternal origin and may influence the activities of steroid hormones that control placental development and/or function. Steroids 109-125 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 11-14 7916682-12 1993 The results presented here suggest that temporal and spatial changes in the localization of CBG and its mRNA in the fetus may influence the effects of steroid hormones on developing tissues. Steroids 151-167 serine (or cysteine) peptidase inhibitor, clade A, member 6 Mus musculus 92-95 8425475-1 1993 The conversion of cholesterol to pregnenolone, the rate-limiting step in steroid hormone synthesis, occurs on mitochondrial cytochrome P450scc, which catalyzes this reaction by receiving electrons from NADPH via a flavoprotein [adrenodoxin reductase (AdRed)] and an iron sulfur protein [adrenodoxin (Adx)]. Steroids 73-88 ferredoxin 1 Homo sapiens 300-303 8428614-6 1993 These results suggest suppressive effects of ovarian steroids on MnSOD activity in the rat brain. Steroids 53-61 superoxide dismutase 2 Rattus norvegicus 65-70 7992552-3 1993 In the same cell model, lovastatin, an inhibitor of beta hydroxy-beta methyl-glutaryl-CoA-reductase and, hence, of farnesylation of p21ras, partially protects aspartate transport from the inhibition observed upon steroid treatment. Steroids 213-220 Harvey rat sarcoma virus oncogene Mus musculus 132-138 8273582-3 1993 Our work has shown that orally administered 5-lipoxygenase inhibitors, dual inhibitors (CO/LO), and steroids dose-dependently inhibit both edema formation and MPO activity, whereas oral activity is not seen with NSAID"s. Steroids 100-108 myeloperoxidase Mus musculus 159-162 8424672-3 1993 5 alpha-Dihydrotestosterone (DHT, an active form of endogenous androgen) stimulated the secretion of PAcP from cells grown in a steroid-reduced medium and in a defined serum-free medium, respectively. Steroids 128-135 acid phosphatase 3 Homo sapiens 101-105 8424672-6 1993 During a 5-day treatment period, with 10 nM of DHT in the steroid-reduced medium, the secretion of PAcP was stimulated approximately 150% over that from control cells. Steroids 58-65 acid phosphatase 3 Homo sapiens 99-103 8424672-9 1993 The expression and the secretion of PAcP were observed in cells that were grown in a defined serum-free medium and grown in a steroid-reduced medium, in the absence of DHT. Steroids 126-133 acid phosphatase 3 Homo sapiens 36-40 8094093-4 1993 Patients on steroids showed a more pronounced decrease of CD4+CD45RO+ cells suggesting, in addition, a drug-related effect. Steroids 12-20 protein tyrosine phosphatase receptor type C Homo sapiens 62-68 1337827-0 1992 Implication of acid cholesteryl ester hydrolase in the regulation of steroid biosynthesis in rat Leydig cells. Steroids 69-76 epoxide hydrolase 2 Rattus norvegicus 20-47 22217822-0 1992 Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis. Steroids 74-89 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 52-70 22217822-1 1992 Transfer of cholesterol to cytochrome P450scc is generally the rate-limiting step in steroid synthesis. Steroids 85-92 cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus 27-45 1279383-0 1992 Regulation of expression of the chicken ovalbumin gene: interactions between steroid hormones and second messenger systems. Steroids 77-93 ovalbumin (SERPINB14) Gallus gallus 40-49 1279383-8 1992 In contrast, the activators of the PKA system can substitute for insulin and, thereby, increase expression of the ovalbumin gene synergistically with the steroids. Steroids 154-162 ovalbumin (SERPINB14) Gallus gallus 114-123 1279383-10 1992 Thus, in chicken oviduct cell cultures, the PKA and PKC signal transduction pathways act in opposing ways to modulate the steroid-induced expression of the ovalbumin gene. Steroids 122-129 ovalbumin (SERPINB14) Gallus gallus 156-165 1321437-4 1992 Here we report on the use of a steroid-inducible promoter expression system for the production of a permanently transfected clonal cell line expressing the alpha 1 beta 1 gamma 2L GABAA receptor subtype. Steroids 31-38 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 164-170 1502922-0 1992 Spa therapy improves ventilatory function in the small airways of patients with steroid-dependent intractable asthma (SDIA). Steroids 80-87 surfactant protein A2 Homo sapiens 0-3 1502922-1 1992 The improvement of ventilatory function by spa therapy was examined in 37 patients with steroid-dependent intractable asthma (SDIA) in relation to clinical asthma types. Steroids 88-95 surfactant protein A2 Homo sapiens 43-46 1580447-0 1992 Prediction of steroid responsiveness in the idiopathic nephrotic syndrome using urinary retinol-binding protein and beta-2-microglobulin. Steroids 14-21 retinol binding protein 4 Homo sapiens 88-111 1580447-9 1992 Median urinary RBP and B2M, before treatment, were significantly higher in the steroid-unresponsive group than in the responsive group (P less than 0.01). Steroids 79-86 retinol binding protein 4 Homo sapiens 15-18 1580447-10 1992 In the steroid-responsive group, urinary RBP and B2M levels decreased significantly after remission (P less than 0.01). Steroids 7-14 retinol binding protein 4 Homo sapiens 41-44 1580447-11 1992 In the steroid-unresponsive group, the likelihood ratios for urinary RBP greater than 4000 micrograms/g creatinine and for B2M greater than 3000 micrograms/g creatinine were 3.8 and 3.0, respectively. Steroids 7-14 retinol binding protein 4 Homo sapiens 69-72 1580447-12 1992 The probability was 100% that values of RBP of less than 1300 micrograms/g creatinine and B2M of less than 130 micrograms/g creatinine were from steroid-responsive patients. Steroids 145-152 retinol binding protein 4 Homo sapiens 40-43 1580447-13 1992 Multivariate analysis confirmed that higher urinary levels of RBP and B2M were associated with a lower likelihood of steroid responsiveness, independent of age and histologic diagnosis. Steroids 117-124 retinol binding protein 4 Homo sapiens 62-65 1580447-15 1992 Pretreatment urinary RBP and B2M levels may be helpful in identifying nephrotic patients who are more likely to be responsive to steroids. Steroids 129-137 retinol binding protein 4 Homo sapiens 21-24 1572314-1 1992 Monoclonal antibodies directed against four different polypeptide epitopes on the Mr approximately 94,000 steroid-binding subunit of the rat liver cytosolic glucocorticoid receptor (GcR) were used to probe Western blots of epididymal spermatozoa from rats and mice. Steroids 106-113 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 157-180 1572314-1 1992 Monoclonal antibodies directed against four different polypeptide epitopes on the Mr approximately 94,000 steroid-binding subunit of the rat liver cytosolic glucocorticoid receptor (GcR) were used to probe Western blots of epididymal spermatozoa from rats and mice. Steroids 106-113 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 182-185 1569177-1 1992 The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid delta 5----4-ene-isomerase (3 beta HSD) is involved in the biosynthesis of all classes of active steroids, namely glucocorticoids, mineralocorticoids, progesterone, and sex steroids. Steroids 171-179 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 102-112 1569177-1 1992 The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid delta 5----4-ene-isomerase (3 beta HSD) is involved in the biosynthesis of all classes of active steroids, namely glucocorticoids, mineralocorticoids, progesterone, and sex steroids. Steroids 247-255 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 102-112 1537280-3 1992 ODC and AdoMetDC mRNAs were regulated in prostate and seminal vesicles in a coordinate fashion, with the maximal levels reached within 24-48 h of steroid exposure. Steroids 146-153 ornithine decarboxylase, structural 1 Mus musculus 0-3 1537280-3 1992 ODC and AdoMetDC mRNAs were regulated in prostate and seminal vesicles in a coordinate fashion, with the maximal levels reached within 24-48 h of steroid exposure. Steroids 146-153 S-adenosylmethionine decarboxylase 1 Mus musculus 8-16 1727646-9 1992 The results of this study point to similarities and differences between the steroid binding properties of the uterine PR occupied by R5020 and ZK98299: both steroids appear to bind the same 8 S receptor but exhibit differential DNA binding and sensitivity to IA. Steroids 76-83 progesterone receptor Bos taurus 118-120 1727646-9 1992 The results of this study point to similarities and differences between the steroid binding properties of the uterine PR occupied by R5020 and ZK98299: both steroids appear to bind the same 8 S receptor but exhibit differential DNA binding and sensitivity to IA. Steroids 157-165 progesterone receptor Bos taurus 118-120 1330003-8 1992 In isolated adrenal cells from 2-week-old rats, rANF (10 nmol/l) inhibited the secretion of aldosterone induced by ACTH(1-24) (0.1 nmol/l), and by different steroids of the aldosterone synthetic pathway (progesterone, 11-deoxycorticosterone, corticosterone, 1 mumol/l for each steroid). Steroids 157-165 natriuretic peptide A Rattus norvegicus 48-52 1330003-8 1992 In isolated adrenal cells from 2-week-old rats, rANF (10 nmol/l) inhibited the secretion of aldosterone induced by ACTH(1-24) (0.1 nmol/l), and by different steroids of the aldosterone synthetic pathway (progesterone, 11-deoxycorticosterone, corticosterone, 1 mumol/l for each steroid). Steroids 157-164 natriuretic peptide A Rattus norvegicus 48-52 1450986-16 1992 Butyrate inhibits the induction of proteins, including enzymes, by steroid hormones as has been shown for the induction of tyrosine aminotransferase by glucocorticoids, of ovalbumin and transferrin by estradiol in chick oviduct. Steroids 67-83 ovalbumin (SERPINB14) Gallus gallus 172-181 1293271-7 1992 We conclude from the meta-analysis of the literature and from the findings of our study, that accelerated lung maturation follows prenatal steroid treatment with a reduction in RDS-incidence even in very immature fetuses. Steroids 139-146 peripherin 2 Homo sapiens 177-180 1299410-3 1992 Using a structural approach to identify domains of the glucocorticoid receptor responsible for interactions with affiliated transacting factors and DNA, we have identified a putative helix-turn-zipper motif that is conserved in all steroid, thyroid hormone, retinoic acid, and vitamin-D3 receptors. Steroids 232-239 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 55-78 1935773-9 1991 The SgII mRNA decrease was initiated only with a higher concentration of E2 (10 micrograms), as was that of alpha-subunit mRNA; yet, the SgII mRNA level remained significantly higher than in the control pituitary, even with the highest steroid dose (P less than 0.05) at variance with the alpha-mRNA level. Steroids 236-243 secretogranin II Rattus norvegicus 4-8 1892851-11 1991 Hybridization analysis of the DNAf from the enriched NAPf demonstrates sequence homologies with the nuclear matrix DNA as well as with genomic sequences of the rapid steroid responding nuclear protooncogenes c-myc and c-jun. Steroids 166-173 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 218-223 1915088-4 1991 Because the mucous secreting cells are targets for steroid hormones it seemed likely that steroids regulate EGF receptor expression. Steroids 51-67 epidermal growth factor receptor Oryctolagus cuniculus 108-120 1915088-4 1991 Because the mucous secreting cells are targets for steroid hormones it seemed likely that steroids regulate EGF receptor expression. Steroids 90-98 epidermal growth factor receptor Oryctolagus cuniculus 108-120 1836005-8 1991 The effects of ovarian steroids on the secretion of hypothalamic ANF and beta-endorphin were determined by measuring the portal plasma concentration of ANF and beta-endorphin on the morning of presumptive pro-oestrus in rats ovariectomized 24 h previously and injected with either oil or oestradial benzoate (OB). Steroids 23-31 natriuretic peptide A Rattus norvegicus 65-68 1892900-10 1991 The avian progesterone receptor, therefore, has unique steroid binding site(s) that exclude(s) interaction with ZK98299. Steroids 55-62 progesterone receptor Gallus gallus 10-31 1944309-1 1991 The 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta HSD) enzyme catalyzes the oxidation and isomerization of delta 5-3 beta-hydroxysteroid precursors into delta 4-ketosteroids, thus leading to the formation of all classes of steroid hormones. Steroids 247-263 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 67-77 1656298-7 1991 alpha-MSH does not appear to affect this action, although it enhances the effect of steroids on the sexual behaviour, probably at the level of the VMN. Steroids 84-92 proopiomelanocortin Rattus norvegicus 0-9 1778301-3 1991 Conversely, another steroid hormone, 1,25-dihydroxy-vitamin D3 (1,25-(OH)2D3) was recently reported to promote NGF synthesis in mouse L929 cells. Steroids 20-35 nerve growth factor Mus musculus 111-114 1778301-6 1991 Therefore, the expression of the NGF gene can be regulated in a subtle way by the balance between the two steroids. Steroids 106-114 nerve growth factor Mus musculus 33-36 2037595-0 1991 A protein with a binding specificity similar to NF-kappa B binds to a steroid-dependent regulatory element in the ovalbumin gene. Steroids 70-77 ovalbumin (SERPINB14) Gallus gallus 114-123 2037595-1 1991 The chicken ovalbumin gene is regulated at the level of transcription by four classes of steroid hormones. Steroids 89-105 ovalbumin (SERPINB14) Gallus gallus 12-21 2037595-4 1991 Fusion genes containing the mutant ovalbumin 5"-flanking sequences linked to the chloramphenicol acetyltransferase structural gene (CAT) were transfected into steroid-responsive primary oviduct cells. Steroids 159-166 ovalbumin (SERPINB14) Gallus gallus 35-44 2037595-12 1991 These data suggest that a protein binding to sequences in the SDRE that are similar to an NF-kappa B-binding site participates in the steroid-mediated increase in transcription of the chicken ovalbumin gene. Steroids 134-141 ovalbumin (SERPINB14) Gallus gallus 192-201 1717064-8 1991 Cycloheximide added to incubation medium with steroid inhibited the stimulating effect on PAL only. Steroids 46-53 leucine-rich repeat, Ig-like and transmembrane domains 1 Rattus norvegicus 90-93 1679516-5 1991 These results indicate that gonadal steroids and PRL are involved, either directly or indirectly, in regulating the biosynthesis of TH and POMC in the hypothalamus. Steroids 36-44 proopiomelanocortin Rattus norvegicus 139-143 2036965-5 1991 The peak of induction of renal calbindin-D28k mRNA was at 12 h after a single injection of 1,25(OH)2D3 (200 ng/100 g body wt) to vitamin D-deficient mice, and a decrease was observed at 24 h (similar to the time course of response of other steroid-regulated genes). Steroids 240-247 calbindin 1 Mus musculus 31-45 2036965-7 1991 Both genes in mouse kidney did not respond to glucocorticoids, although a dose-dependent decrease (12-86%) of mouse intestinal calbindin-D9k mRNA was observed after dexamethasone treatment, suggesting tissue-specific multiple steroid interactions in the regulation of calbindin gene expression. Steroids 226-233 calbindin 1 Mus musculus 127-136 1936521-1 1991 Expression of the vitamin D induced calbindin-D28K protein is transcriptionally controlled by the steroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in a tissue-specific manner in the intestine and kidney. Steroids 98-113 calbindin 1 Gallus gallus 18-22 1828177-12 1991 The findings of this study serve to demonstrate that: (i) hepatic protein levels are affected by DHEA treatment of mice and rats; (ii) liver CPS-I activity is decreased significantly by DHEA treatment, but serum urea levels remain within the normal range; and (iii) sex steroids and some of their precursors, when administered per os, also alter liver protein levels. Steroids 270-278 carbamoyl-phosphate synthetase 1 Mus musculus 141-146 1926586-2 1991 It is shown that an increase of total activity of acid phosphatase and malate dehydrogenase with administration of a steroid hormone is promoted by growth of activity of certain inducible multiple forms of the studied enzymes. Steroids 117-132 malic enzyme 1 Homo sapiens 71-91 1850510-1 1991 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones. Steroids 159-167 thyroid hormone receptor alpha Homo sapiens 4-34 1850510-1 1991 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones. Steroids 159-167 thyroid hormone receptor alpha Homo sapiens 36-40 1850510-1 1991 The thyroid hormone receptor alpha (THRA or c-erbA-1) gene belongs to a family of genes which encode nuclear receptors for various hydrophobic ligands such as steroids, vitamin D, retinoic acid and thyroid hormones. Steroids 159-167 thyroid hormone receptor alpha Homo sapiens 44-52 1847384-2 1991 The mitochondrial (peripheral-type) benzodiazepine receptor (MBR) is a drug binding site associated with outer mitochondrial membranes which is coupled to intramitochondrial cholesterol transport, the rate-determining step of steroid biosynthesis. Steroids 226-233 translocator protein Homo sapiens 61-64 1847384-8 1991 These observations provide unequivocal evidence that the antagonistic action of flunitrazepam is mediated through its interaction with MBR demonstrating that these drug recognition sites are coupled to steroid biosynthesis activated by tropic hormones. Steroids 202-209 translocator protein Homo sapiens 135-138 1996987-0 1991 Hepatic glucocorticoid receptor behaves differently when its hormone binding site is occupied by agonist (triamcinolone acetonide) or antagonist (RU486) steroid ligands. Steroids 153-160 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 8-31 1996987-7 1991 These results indicate that either a) the interaction of GR with the agonist or antagonist steroid ligands causes differential structural alterations, which are more readily detectable in the presence of SH-modifying agents or b) the agonist and the antagonist interact with distinct steroid binding sites. Steroids 91-98 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 57-59 1996987-7 1991 These results indicate that either a) the interaction of GR with the agonist or antagonist steroid ligands causes differential structural alterations, which are more readily detectable in the presence of SH-modifying agents or b) the agonist and the antagonist interact with distinct steroid binding sites. Steroids 284-291 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 57-59 2050270-1 1991 The conversion of 3 beta-hydroxy-5-ene steroids by the enzyme complex 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) is an obligatory step in the biosynthesis of all classes of hormonal steroids in classical steroidogenic as well as in peripheral tissues. Steroids 39-47 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 133-143 1985950-3 1991 Experimental evidence indicates that the purified nonactivated glucocorticoid receptor contains a single steroid-binding protein and two approximately 90-kDa nonsteroid-binding subunits identified as heat shock protein (hsp) 90. Steroids 105-112 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 63-86 1985950-5 1991 The cell-free synthesized glucocorticoid receptor is able to bind steroid and can be activated further to the DNA-binding form. Steroids 66-73 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 26-49 1985950-6 1991 To test the hypothesis of an active role played by hsp90 in the stabilization of a competent steroid-binding conformation of the glucocorticoid receptor, we have synthesized the receptor in a reticulocyte lysate that has been depleted of hsp90 by immunoadsorption with AC88 anti-hsp90. Steroids 93-100 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 129-152 2016261-0 1991 The Mr 90,000 heat shock protein-free androgen receptor has a high affinity for steroid, in contrast to the glucocorticoid receptor. Steroids 80-87 androgen receptor Rattus norvegicus 38-55 2016261-4 1991 The C-terminal portion of the rat androgen receptor containing the putative steroid-binding domain was expressed as a fusion protein of protein A in Escherichia coli. Steroids 76-83 androgen receptor Rattus norvegicus 34-51 2016261-7 1991 The steroid-free transformed androgen receptor was obtained by exposure of rat submandibular gland cytosol to 0.4 M NaCl in the absence of steroid. Steroids 4-11 androgen receptor Rattus norvegicus 29-46 2016261-7 1991 The steroid-free transformed androgen receptor was obtained by exposure of rat submandibular gland cytosol to 0.4 M NaCl in the absence of steroid. Steroids 139-146 androgen receptor Rattus norvegicus 29-46 2177625-4 1990 These studies show that in LOCAH, in addition to the unconjugated steroids AD and T, the sulphoconjugated steroids DHEA-S, 5-ADIOL-S and 3 alpha-DIOL-S are increased, as is the glucuronide conjugate 3 alpha-DIOL-G and the index of bioavailable testosterone (FAI), and that mean SHBG levels are depressed. Steroids 106-114 sulfotransferase family 2A member 1 Homo sapiens 115-121 2278831-0 1990 The steroid-binding properties of recombinant glucocorticoid receptor: a putative role for heat shock protein hsp90. Steroids 4-11 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 46-69 2278831-2 1990 The recombinant proteins were found to bind steroids with the normal specificity for a glucocorticoid receptor but with reduced affinity (Kd for triamcinolone acetonide approximately 70 nM). Steroids 44-52 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 87-110 2221596-7 1990 Two patients with BAL-documented CD8+ alveolitis tolerated discontinuation of steroids. Steroids 78-86 CD8a molecule Homo sapiens 33-36 2222533-3 1990 This model predicts the suppression of serum BGP with low dosages of steroids and 50% suppression with dosages of 20-25 mg/day. Steroids 69-77 CEA cell adhesion molecule 1 Homo sapiens 45-48 2209604-2 1990 Since the main biosynthetic pathway of PAF involves acetylation of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) generated from 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine by phospholipase A2, we suggest a general physiological role played by steroid-induced anti-(phospholipase A2) proteins in the modulation of PAF synthesis. Steroids 247-254 PCNA clamp associated factor Rattus norvegicus 39-42 2209604-2 1990 Since the main biosynthetic pathway of PAF involves acetylation of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) generated from 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine by phospholipase A2, we suggest a general physiological role played by steroid-induced anti-(phospholipase A2) proteins in the modulation of PAF synthesis. Steroids 247-254 PCNA clamp associated factor Rattus norvegicus 111-114 2209604-2 1990 Since the main biosynthetic pathway of PAF involves acetylation of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) generated from 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine by phospholipase A2, we suggest a general physiological role played by steroid-induced anti-(phospholipase A2) proteins in the modulation of PAF synthesis. Steroids 247-254 PCNA clamp associated factor Rattus norvegicus 111-114 2226278-3 1990 Both the natural and synthetic steroid caused a rapid decrease of receptor binding in the cytosol but the time course of glucocorticoid receptor depletion was different. Steroids 31-38 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 121-144 2351102-1 1990 The enzyme complex 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) is involved in the biosynthesis of all classes of active steroids, namely glucocorticoids, mineralocorticoids, progesterone, and sex hormone steroids. Steroids 158-166 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 89-99 2233745-0 1990 Diurnal pattern of proopiomelanocortin gene expression in the arcuate nucleus of proestrous, ovariectomized, and steroid-treated rats: a possible role in cyclic luteinizing hormone secretion. Steroids 113-120 proopiomelanocortin Rattus norvegicus 19-38 2233745-2 1990 We tested the hypothesis that changes in proopiomelanocortin (POMC) gene expression occur in proestrous (PRO) and ovariectomized (OVX) steroid-treated rats which may explain their unique patterns of LH secretion. Steroids 135-142 proopiomelanocortin Rattus norvegicus 41-60 2233745-2 1990 We tested the hypothesis that changes in proopiomelanocortin (POMC) gene expression occur in proestrous (PRO) and ovariectomized (OVX) steroid-treated rats which may explain their unique patterns of LH secretion. Steroids 135-142 proopiomelanocortin Rattus norvegicus 62-66 2332444-1 1990 Transcription of the chicken ovalbumin gene is induced both in vivo and in vitro by four classes of steroid hormones. Steroids 100-116 ovalbumin (SERPINB14) Gallus gallus 29-38 2332444-4 1990 When the ovalbumin-chloramphenicol acetyltransferase fusion genes were transfected into steroid-responsive primary oviduct cells, mutants lacking sequences between -900 and -732 were no longer responsive to estrogen, corticosterone, progesterone, or dihydrotestosterone. Steroids 88-95 ovalbumin (SERPINB14) Gallus gallus 9-18 2332444-10 1990 These data indicate that induction of the ovalbumin gene by steroid hormones requires complex interactions involving both the SDRE and the negative regulatory element. Steroids 60-76 ovalbumin (SERPINB14) Gallus gallus 42-51 2385358-0 1990 Regulation of proopiomelanocortin messenger ribonucleic acid content by sex steroids in the arcuate nucleus of the female rat brain. Steroids 76-84 proopiomelanocortin Rattus norvegicus 14-33 2385358-1 1990 It has been recently demonstrated that sex steroids can negatively regulate beta-endorphin content as well as proopiomelanocortin (POMC) mRNA levels in the rat basal hypothalamus. Steroids 43-51 proopiomelanocortin Rattus norvegicus 110-129 2385358-1 1990 It has been recently demonstrated that sex steroids can negatively regulate beta-endorphin content as well as proopiomelanocortin (POMC) mRNA levels in the rat basal hypothalamus. Steroids 43-51 proopiomelanocortin Rattus norvegicus 131-135 2385358-5 1990 These results suggest that sex steroids exert their action in subpopulations of POMC neurons. Steroids 31-39 proopiomelanocortin Rattus norvegicus 80-84 2154488-6 1990 264, 20415-20421); and in this report, we present evidence that PBR are functionally linked to Leydig cell steroid biosynthesis. Steroids 107-114 translocator protein Homo sapiens 64-67 2308930-4 1990 This element (CTGGGTGAATGAGGACATTACTGACC), identified at single nucleotide resolution, contains a region of hyphenated dyad symmetry and shares sequence homology with consensus steroid-responsive elements and with the sequence that has been identified as the vitamin D receptor binding site in the human osteocalcin gene. Steroids 177-184 vitamin D receptor Homo sapiens 259-277 2297768-7 1990 When we studied the effect of the steroid on the two utilization pathways of NADPH generated by G6PD activity, we observed that, in the cells treated with estradiol, there is an increase in reducing equivalents generated by G6PD activity which only affects the NADPH2 pathway, and that there is cell growth stimulation. Steroids 34-41 glucose-6-phosphate dehydrogenase Homo sapiens 96-100 2297768-7 1990 When we studied the effect of the steroid on the two utilization pathways of NADPH generated by G6PD activity, we observed that, in the cells treated with estradiol, there is an increase in reducing equivalents generated by G6PD activity which only affects the NADPH2 pathway, and that there is cell growth stimulation. Steroids 34-41 glucose-6-phosphate dehydrogenase Homo sapiens 224-228 2298732-1 1990 Low concentrations of arsenite, but not arsenate, and Cd2+ blocked steroid binding to the glucocorticoid receptors of HTC cells. Steroids 67-74 Cd2 molecule Rattus norvegicus 54-57 2298732-11 1990 In contrast, Cd2+ concentrations similar to those that block steroid binding caused a biphasic loss of unactivated complexes and a marginal loss of activated complexes. Steroids 61-68 Cd2 molecule Rattus norvegicus 13-16 2314540-0 1990 Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment. Steroids 161-168 lecithin-cholesterol acyltransferase Homo sapiens 0-69 29914889-9 2018 Accordingly, steroid efficacy to transactivate MKP-1 and GILZ and to downregulate p-p38, p-GATA-3 as well as proinflammatory cytokine levels was also seen after two but not four provocations. Steroids 13-20 dual specificity phosphatase 1 Mus musculus 47-52 29914889-9 2018 Accordingly, steroid efficacy to transactivate MKP-1 and GILZ and to downregulate p-p38, p-GATA-3 as well as proinflammatory cytokine levels was also seen after two but not four provocations. Steroids 13-20 TSC22 domain family, member 3 Mus musculus 57-61 25763641-9 2015 Gestational T disrupted associations of steroids with metabolites and progesterone with acylcarnitines, which was prevented either by androgen antagonist or insulin sensitizer cotreatment. Steroids 40-48 LOC105613195 Ovis aries 157-164 18333700-7 2008 CONCLUSION: Spa resort treatment of thyroidectomized women substituted with thyroid hormones resulted in significant, mostly beneficial effects on steroid spectrum. Steroids 147-154 surfactant protein A2 Homo sapiens 12-15 34959084-7 2022 Taken together, we found that both porcine miR-20b and miR-31 target HSD17B14 gene, but miR-31 also targets FSHR gene to regulate the metabolism of steroid hormones and the apoptosis of porcine ovarian GCs. Steroids 148-155 follicle stimulating hormone receptor Homo sapiens 108-112 34838638-1 2022 Bone morphogenetic protein-6 (BMP-6) and dihydrotestosterone (DHT) affect steroid synthesis in follicles and regulate cell proliferation in the ovaries of female animals. Steroids 74-81 bone morphogenetic protein 6 Ovis aries 0-28 34838638-1 2022 Bone morphogenetic protein-6 (BMP-6) and dihydrotestosterone (DHT) affect steroid synthesis in follicles and regulate cell proliferation in the ovaries of female animals. Steroids 74-81 bone morphogenetic protein 6 Ovis aries 30-35 34844141-3 2022 More recently, a role for the Vitamin D Receptor in mediating inhibition of Hh-signaling by seco-steroid has been suggested. Steroids 97-104 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 30-48 34948471-10 2021 Samples positive for FSHR-aAb displayed steroid hormones in the typical range of PCOS patients, whereas the two samples positive for LHR-aAb showed relatively elevated free testosterone in relation to total testosterone concentrations with unclear significance. Steroids 40-47 follicle stimulating hormone receptor Homo sapiens 21-25 34272607-3 2021 RESULTS: The patient was found to be de-novo heterozygous for pathogenic KCNJ11 missense variant: c.190G > A, p. (Val64Met), associated with DEND syndrome, responsive to a combination of super high doses of sulfonylurea (SU) and oral high-dose steroids. Steroids 244-252 potassium inwardly rectifying channel subfamily J member 11 Homo sapiens 73-79 34890031-1 2021 Adipocytes express various enzymes, such as aldo-keto reductases (AKR1C), 11beta-hydroxysteroid dehydrogenase (11beta-HSD), aromatase, 5alpha-reductases, 3beta-HSD, and 17beta-HSDs involved in steroid hormone metabolism in adipose tissues. Steroids 193-200 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 154-163 34581457-0 2021 MSI2 expression in adrenocortical carcinoma: Association with unfavorable prognosis and correlation with steroid and immune-related pathways. Steroids 105-112 musashi RNA binding protein 2 Homo sapiens 0-4 34710830-0 2021 Modulation of E-Cadherin and N-Cadherin by ovarian steroids and embryonic stimuli. Steroids 51-59 cadherin 2 Mus musculus 29-39 34870111-4 2021 In this regard, the steroid hormone 20-hydroxyecdysone (20E) represents an intriguing candidate for regulating glycolytic gene expression in embryos - not only does the embryonic 20E pulse immediately precede transcriptional up-regulation of glycolytic metabolism, but 20E is also known to promote Lactate dehydrogenase gene expression. Steroids 20-27 Lactate dehydrogenase Drosophila melanogaster 298-319 34795643-12 2021 Taken together, these results help to affirm the fact that ARC kisspeptin may have a novel amplificatory role in LH surge production, which is dependent on the gonadal steroid milieu. Steroids 168-175 KiSS-1 metastasis-suppressor Mus musculus 63-73 34398459-3 2021 We present a 14-year-old girl of Chinese heritage who was diagnosed with SPTCL in the context of homozygous HAVCR2 status for c.245A>G p. (Tyr82Cys) and achieved complete remission after treatment with cyclosporin and steroids. Steroids 218-226 hepatitis A virus cellular receptor 2 Homo sapiens 108-114 34487832-10 2021 In addition to this, VPA commonly affected many steroid metabolism related genes in follicle cells, such as promoting the expression of vitamin D receptor (VDR). Steroids 48-55 vitamin D receptor Homo sapiens 136-154 34487832-10 2021 In addition to this, VPA commonly affected many steroid metabolism related genes in follicle cells, such as promoting the expression of vitamin D receptor (VDR). Steroids 48-55 vitamin D receptor Homo sapiens 156-159 34547381-2 2021 Previous studies have demonstrated that the expression of Cyclooxygenase-2 (COX-2), an enzyme limiting PGF2alpha rate, is regulated by steroid hormones, and also dihydrotestosterone (DHT) may be involved in regulating COX-2 expression both positively and negatively. Steroids 135-142 prostaglandin-endoperoxide synthase 2 Bos taurus 58-74 34547381-2 2021 Previous studies have demonstrated that the expression of Cyclooxygenase-2 (COX-2), an enzyme limiting PGF2alpha rate, is regulated by steroid hormones, and also dihydrotestosterone (DHT) may be involved in regulating COX-2 expression both positively and negatively. Steroids 135-142 prostaglandin-endoperoxide synthase 2 Bos taurus 76-81 34828897-8 2021 KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis of the results indicated that in the comparison of the GSF group with the SF group, differentially expressed genes (DEGs) such as LIPC, ERFE, FABP3, PLA2R1, LDLR, and SLC10A6, were enriched in the steroid biosynthesis and cholesterol metabolism pathways. Steroids 253-260 hepatic triacylglycerol lipase Ovis aries 186-190 34463264-2 2021 LCN-2 is a circulatory protein responsible for the transportation of small and hydrophobic molecules (steroid, free fatty acids, prostaglandins and hormones) to target organs after binding to megalin/glycoprotein and GP330 SLC22A17 or 24p3R LCN-2 receptors. Steroids 102-109 lipocalin 2 Homo sapiens 0-5 34568711-8 2021 The 50% maximal MR activation for the reporter gene stimulation by corticosterone rose with increasing 11betaHSD2 expression, shifting the steroid dose-response curve for corticosterone-induced MR transactivation to the right. Steroids 139-146 hydroxysteroid 11-beta dehydrogenase 2 Rattus norvegicus 103-113 34171490-1 2021 Research into the biosynthesis of C11-oxy C19 steroids during human fetal development, specifically fetal adrenal development and during the critical period of sex differentiation, is currently lacking. Steroids 46-54 aldo-keto reductase family 1 member C4 Homo sapiens 34-37 34296248-7 2021 Our work demonstrates a novel mode of action for 20E signaling in Drosophila that likely functions beyond DC, and may provide further insights into mammalian steroid hormone receptor interactions with AP-1. Steroids 158-165 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 201-205 34436366-9 2021 CD45+, CD3+CD4+ (Th cell), CD3+CD8+, CD4+/CD8+, the NK cell subpopulation, neutrophils, monocytes, and basophils were significantly reduced by Steroids + Tocilizumab without an effect modification by VV-ECMO support. Steroids 143-151 protein tyrosine phosphatase receptor type C Homo sapiens 0-4 34301840-3 2021 In this study, we used a murine model of steroid-resistant airway inflammation and report that combining systemic dexamethasone and intranasal IL-27 is able to reverse the inflammation. Steroids 41-48 interleukin 27 Mus musculus 143-148 34301840-4 2021 Foxp3+ regulatory T cells (Tregs) were required during dexamethasone/IL-27 treatment of steroid-resistant allergic inflammation, and importantly, direct stimulation of Tregs via glucocorticoid or IL-27 receptors was essential. Steroids 88-95 interleukin 27 Mus musculus 69-74 34301840-4 2021 Foxp3+ regulatory T cells (Tregs) were required during dexamethasone/IL-27 treatment of steroid-resistant allergic inflammation, and importantly, direct stimulation of Tregs via glucocorticoid or IL-27 receptors was essential. Steroids 88-95 interleukin 27 Mus musculus 196-201 34198681-9 2021 The findings presented provide insights into differences between male and female cells in response to female sex steroid hormones and the involvement of the cAMP pathway in elastin synthesis. Steroids 113-120 elastin Homo sapiens 173-180 34099654-0 2021 The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. Steroids 4-11 Insulin-like peptide 8 Drosophila melanogaster 127-132 34099654-0 2021 The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction. Steroids 4-11 Leucine-rich repeat-containing G protein-coupled receptor 3 Drosophila melanogaster 133-137 34099654-4 2021 We find that the steroid-hormone ecdysone triggers parallel pupariation neuromotor and morphogenetic subprograms, which include the induction of the relaxin-peptide hormone, Dilp8, in the epidermis. Steroids 17-24 Insulin-like peptide 8 Drosophila melanogaster 174-179 35398259-3 2022 Previous study suggested that, among the porcine AKR1Cs, AKR1C1 and AKR1C4 play important roles in steroid hormone metabolism in the reproductive tissues; however, their biological functions are still unknown. Steroids 99-106 aldo-keto reductase family 1 member C4 Homo sapiens 68-74 35224759-1 2022 BACKGROUND: Amphiregulin (AREG) is increased in circulation in acute graft-versus-host disease (aGVHD) and is associated with poor steroid response and lower survival. Steroids 131-138 amphiregulin Homo sapiens 12-24 35224759-1 2022 BACKGROUND: Amphiregulin (AREG) is increased in circulation in acute graft-versus-host disease (aGVHD) and is associated with poor steroid response and lower survival. Steroids 131-138 amphiregulin Homo sapiens 26-30 35532160-5 2022 Contributing to this research gap is the lack of information on effect of sex steroid hormones on CFTR expression in cervix epithelial cells across the menstrual cycle. Steroids 78-85 CF transmembrane conductance regulator Macaca mulatta 98-102 35532160-10 2022 Our findings provide the most comprehensive evidence to date that steroid hormones drive changes in CFTR expression. Steroids 66-73 CF transmembrane conductance regulator Macaca mulatta 100-104 35020444-15 2022 CONCLUSIONS: Apalutamide-related dAE are frequent and can be managed with topical +-oral steroids. Steroids 89-97 Anion exchanger 2 Drosophila melanogaster 33-36 35563774-0 2022 Reciprocal Regulation between lncRNA ANRIL and p15 in Steroid-Induced Glaucoma. Steroids 54-61 CDKN2B antisense RNA 1 Homo sapiens 37-42 35563774-15 2022 Molecular therapy targeting the ANRIL/p15 signal exerted a protective effect against steroid treatment and shed new light on glaucoma management. Steroids 85-92 CDKN2B antisense RNA 1 Homo sapiens 32-37 35421859-1 2022 INTRODUCTION: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently described steroid-responsive meningoencephalomyelitis positive for cerebrospinal fluid (CSF) anti-GFAP antibody. Steroids 103-110 glial fibrillary acidic protein Homo sapiens 25-56 35421859-1 2022 INTRODUCTION: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a recently described steroid-responsive meningoencephalomyelitis positive for cerebrospinal fluid (CSF) anti-GFAP antibody. Steroids 103-110 glial fibrillary acidic protein Homo sapiens 58-62 35496916-1 2022 TRPM3 is a calcium-permeable cation channel expressed in a range of sensory neurons that can be activated by heat and the endogenous steroid pregnenolone sulfate (PS). Steroids 133-140 transient receptor potential cation channel, subfamily M, member 3 Mus musculus 0-5 35463412-3 2022 Weak induction of constitutively active MAPKKs driven by steroid-inducible promoter, which activates endogenous MPK3 and MPK6, induces leaf senescence. Steroids 57-64 mitogen-activated protein kinase 3 Arabidopsis thaliana 112-116 35463412-3 2022 Weak induction of constitutively active MAPKKs driven by steroid-inducible promoter, which activates endogenous MPK3 and MPK6, induces leaf senescence. Steroids 57-64 MAP kinase 6 Arabidopsis thaliana 121-125 35395639-10 2022 Patients from lower-SES zip codes were more likely to require postoperative steroid replacement and less likely to achieve gross-total resection. Steroids 76-83 death associated protein kinase 3 Homo sapiens 24-27