PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29932882-9	2018	After treatment with Nutlin, increased nuclear localization of p53 (4.05%-80.56%) was observed in pterygium cells along with increasing Nutlin dosages (from 0 to 50 muM, p < 0.001).	nutlin	21-27	tumor protein p53	Homo sapiens	63-66
33216890-2	2020	There is concern, however, that nutlin therapy might stimulate the emergence or expansion of TP53-mutated subclones.	nutlin	32-38	tumor protein p53	Homo sapiens	93-97
31036564-8	2019	Further experiments suggested that MDM2 amplification increases histone methylation in Nutlin-treated cells by causing depletion of the histone demethylase Jumonji domain-containing protein 2B (JMJD2B).	nutlin	87-93	MDM2 proto-oncogene	Homo sapiens	35-39
31036564-8	2019	Further experiments suggested that MDM2 amplification increases histone methylation in Nutlin-treated cells by causing depletion of the histone demethylase Jumonji domain-containing protein 2B (JMJD2B).	nutlin	87-93	lysine demethylase 4B	Homo sapiens	156-192
31036564-8	2019	Further experiments suggested that MDM2 amplification increases histone methylation in Nutlin-treated cells by causing depletion of the histone demethylase Jumonji domain-containing protein 2B (JMJD2B).	nutlin	87-93	lysine demethylase 4B	Homo sapiens	194-200
30832755-0	2019	Nutlin-3-induced Sensitization of Non-Small Cell Lung Cancer Stem Cells to Axitinib-Induced Apoptosis through Repression of Akt1/Wnt Signaling.	nutlin	0-6	AKT serine/threonine kinase 1	Homo sapiens	124-128
31607444-5	2019	In contrast, P53 induction by Nutlin and Hsp90 inhibitor AUY922 enhanced the BBB function.	nutlin	30-36	tumor protein p53	Homo sapiens	13-16
30794402-6	2019	We extracted the binding pocket of Nutlin from the crystal structure of Nutlin bound MDM2.	nutlin	35-41	MDM2 proto-oncogene	Homo sapiens	85-89
29932882-10	2018	The expression of p21 was increased after Nutlin treatments in pterygium cells (2.49 folds in 20 muM Nutlin treated cells compared to control treated cells, p = 0.012).	nutlin	42-48	H3 histone pseudogene 16	Homo sapiens	18-21
26046940-8	2015	By contrast, Nutlin or benzodiazepinedione inhibitors, that bind with similar affinity to full lid and lid-truncated MDM2 constructs, interact additionally through their solubilizing groups with N-terminal lid residues that are more disordered in apo MDM2.	nutlin	13-19	MDM2 proto-oncogene	Homo sapiens	117-121
26959882-6	2016	We compared its effect to MI-219 and Nutlin, which are less potent MDM2 antagonists than SAR405838.	nutlin	37-43	MDM2 proto-oncogene	Homo sapiens	67-71
26883108-7	2016	In addition, combined treatment with GSK2830371 and doxorubicin or nutlin-3 potentiated cell death through a strong induction of p53 pathway and activation of caspase 9.	nutlin	67-73	tumor protein p53	Homo sapiens	129-132
26883108-7	2016	In addition, combined treatment with GSK2830371 and doxorubicin or nutlin-3 potentiated cell death through a strong induction of p53 pathway and activation of caspase 9.	nutlin	67-73	caspase 9	Homo sapiens	159-168
26046940-8	2015	By contrast, Nutlin or benzodiazepinedione inhibitors, that bind with similar affinity to full lid and lid-truncated MDM2 constructs, interact additionally through their solubilizing groups with N-terminal lid residues that are more disordered in apo MDM2.	nutlin	13-19	MDM2 proto-oncogene	Homo sapiens	251-255
24885082-3	2014	In this study we aimed to investigate the functional role of this p53 acetylation in nutlin-sensitivity, and further to explore if nutlin-induced protein acetylation in general could indicate novel targets for the enhancement of nutlin-based therapy.	nutlin	85-91	tumor protein p53	Homo sapiens	66-69
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	nutlin	41-47	mitogen-activated protein kinase 8	Homo sapiens	101-104
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	nutlin	41-47	tumor protein p53	Homo sapiens	144-147
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	nutlin	41-47	mitogen-activated protein kinase 1	Homo sapiens	185-188
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	nutlin	41-47	tumor protein p53	Homo sapiens	362-365
23114582-8	2012	Selective inhibition of these pathways may synergize with nutlin in the induction of p53 transcriptional activity.	nutlin	58-64	transformation related protein 53, pseudogene	Mus musculus	85-88
23856246-5	2013	Furthermore, we identify pharmacogenomic correlations between specific variants in genes such as TP53, BRAF, ERBBs, and ATAD5 and anticancer agents such as nutlin, vemurafenib, erlotinib, and bleomycin showing one of many ways the data could be used to validate and generate novel hypotheses for further investigation.	nutlin	156-162	tumor protein p53	Homo sapiens	97-101
23856246-5	2013	Furthermore, we identify pharmacogenomic correlations between specific variants in genes such as TP53, BRAF, ERBBs, and ATAD5 and anticancer agents such as nutlin, vemurafenib, erlotinib, and bleomycin showing one of many ways the data could be used to validate and generate novel hypotheses for further investigation.	nutlin	156-162	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	103-107
23856246-5	2013	Furthermore, we identify pharmacogenomic correlations between specific variants in genes such as TP53, BRAF, ERBBs, and ATAD5 and anticancer agents such as nutlin, vemurafenib, erlotinib, and bleomycin showing one of many ways the data could be used to validate and generate novel hypotheses for further investigation.	nutlin	156-162	ATPase family AAA domain containing 5	Homo sapiens	120-125
22476102-7	2012	Furthermore, adaptation to RITA was associated with fewer changes at the expression level of antiapoptotic factors than observed with adaptation to nutlin-3.	nutlin	148-154	zinc finger protein 331	Homo sapiens	27-31
22872685-0	2012	Combination treatment in vitro with Nutlin, a small-molecule antagonist of MDM2, and pegylated interferon-alpha 2a specifically targets JAK2V617F-positive polycythemia vera cells.	nutlin	36-42	MDM2 proto-oncogene	Homo sapiens	75-79
22578852-11	2012	From these results, we concluded that nutlin-3 has an antitumor effect on feline lymphoma cell lines harboring the wt-p53 gene through accumulation and activation of P53 leading to cell cycle arrest and apoptosis.	nutlin	38-44	tumor protein p53	Homo sapiens	118-121
22578852-11	2012	From these results, we concluded that nutlin-3 has an antitumor effect on feline lymphoma cell lines harboring the wt-p53 gene through accumulation and activation of P53 leading to cell cycle arrest and apoptosis.	nutlin	38-44	tumor protein p53	Homo sapiens	166-169
20871630-8	2011	p21 was found to mediate nutlin-induced p53-dependent downregulation of another antiapoptotic protein, survivin, without significantly affecting the apoptotic outcome.	nutlin	25-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
20871630-8	2011	p21 was found to mediate nutlin-induced p53-dependent downregulation of another antiapoptotic protein, survivin, without significantly affecting the apoptotic outcome.	nutlin	25-31	tumor protein p53	Homo sapiens	40-43
19737973-7	2009	Retinoblastoma family members (pRb, p107, and p130) previously implicated in gene silencing during fibroblasts senescence were found down-regulated in cells with nutlin-induced senescence-like phenotype, suggesting a mechanism for its reversibility.	nutlin	162-168	RB transcriptional corepressor 1	Homo sapiens	31-34
20424123-10	2010	In contrast, doxorubicin or nutlin-3 treatment-both leading to p53-p21 activation-or CDK2 inhibition had no effect on SKP2 regulation in MYCN-amplified cells.	nutlin	28-34	tumor protein p53	Homo sapiens	63-66
20424123-10	2010	In contrast, doxorubicin or nutlin-3 treatment-both leading to p53-p21 activation-or CDK2 inhibition had no effect on SKP2 regulation in MYCN-amplified cells.	nutlin	28-34	H3 histone pseudogene 16	Homo sapiens	67-70
20371712-3	2010	Previous studies have reported that Nutlin promotes growth arrest and/or apoptosis in cancer cells that express wild-type p53.	nutlin	36-42	tumor protein p53	Homo sapiens	122-125
20371712-9	2010	Taken together, these findings reveal that Nutlin treatment can inhibit the migration and invasion capacity of p53 wild-type cells, adding to the potential therapeutic benefit of Nutlin and other small molecule MDM2 inhibitors.	nutlin	43-49	tumor protein p53	Homo sapiens	111-114
20371712-9	2010	Taken together, these findings reveal that Nutlin treatment can inhibit the migration and invasion capacity of p53 wild-type cells, adding to the potential therapeutic benefit of Nutlin and other small molecule MDM2 inhibitors.	nutlin	43-49	MDM2 proto-oncogene	Homo sapiens	211-215
19903807-0	2009	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.	nutlin	52-58	transformed mouse 3T3 cell double minute 2	Mus musculus	36-40
19903807-0	2009	Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.	nutlin	52-58	transformation related protein 53, pseudogene	Mus musculus	113-116
19723889-7	2009	miR-16 was also shown to augment apoptosis induction by nutlin, a mouse double minute 2 (MDM2) antagonist, and genistein, a tyrosine kinase inhibitor, when added to a B-1 cell line derived from multiple in vivo passages of malignant B-1 cells from New Zealand Black mice with CLL.	nutlin	56-62	microRNA 16-1	Mus musculus	0-6
20850924-1	2010	This study demonstrated a pronounced synergistic growth-inhibitory effect of an MDM2 inhibitor Nutlin-3 and a proteasome inhibitor bortezomib in mantle cell lymphoma (MCL) cells regardless of TP53 mutant status and innate bortezomib sensitivity.	nutlin	95-101	MDM2 proto-oncogene	Homo sapiens	80-84
21062913-0	2010	RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.	nutlin	134-140	zinc finger protein 331	Homo sapiens	0-4
19737973-7	2009	Retinoblastoma family members (pRb, p107, and p130) previously implicated in gene silencing during fibroblasts senescence were found down-regulated in cells with nutlin-induced senescence-like phenotype, suggesting a mechanism for its reversibility.	nutlin	162-168	RB transcriptional corepressor like 1	Homo sapiens	36-40
19723889-7	2009	miR-16 was also shown to augment apoptosis induction by nutlin, a mouse double minute 2 (MDM2) antagonist, and genistein, a tyrosine kinase inhibitor, when added to a B-1 cell line derived from multiple in vivo passages of malignant B-1 cells from New Zealand Black mice with CLL.	nutlin	56-62	transformed mouse 3T3 cell double minute 2	Mus musculus	89-93
19737973-7	2009	Retinoblastoma family members (pRb, p107, and p130) previously implicated in gene silencing during fibroblasts senescence were found down-regulated in cells with nutlin-induced senescence-like phenotype, suggesting a mechanism for its reversibility.	nutlin	162-168	RB transcriptional corepressor like 2	Homo sapiens	46-50
19509161-12	2009	A combination of vincristine or actinomycin D with nutlin-3 enhanced the antitumor activity in RMS cell lines with wild-type p53.	nutlin	51-57	tumor protein p53	Homo sapiens	125-128
19190243-4	2009	Of note, Nutlin-3 up-regulated Notch1 expression also in primary TP53(wild-type) B-chronic lymphocytic leukemia (B-CLL) cells and the combined use of Nutlin-3 plus pharmacological gamma-secretase inhibitors of the Notch signaling showed a synergistic cytotoxicity in both TP53(wild-type) leukemic cell lines and primary B-CLL cells.	nutlin	9-15	notch receptor 1	Homo sapiens	31-37
19190243-4	2009	Of note, Nutlin-3 up-regulated Notch1 expression also in primary TP53(wild-type) B-chronic lymphocytic leukemia (B-CLL) cells and the combined use of Nutlin-3 plus pharmacological gamma-secretase inhibitors of the Notch signaling showed a synergistic cytotoxicity in both TP53(wild-type) leukemic cell lines and primary B-CLL cells.	nutlin	9-15	tumor protein p53	Homo sapiens	65-69
19190243-4	2009	Of note, Nutlin-3 up-regulated Notch1 expression also in primary TP53(wild-type) B-chronic lymphocytic leukemia (B-CLL) cells and the combined use of Nutlin-3 plus pharmacological gamma-secretase inhibitors of the Notch signaling showed a synergistic cytotoxicity in both TP53(wild-type) leukemic cell lines and primary B-CLL cells.	nutlin	9-15	notch receptor 1	Homo sapiens	31-36
19190243-4	2009	Of note, Nutlin-3 up-regulated Notch1 expression also in primary TP53(wild-type) B-chronic lymphocytic leukemia (B-CLL) cells and the combined use of Nutlin-3 plus pharmacological gamma-secretase inhibitors of the Notch signaling showed a synergistic cytotoxicity in both TP53(wild-type) leukemic cell lines and primary B-CLL cells.	nutlin	9-15	tumor protein p53	Homo sapiens	272-276
16505116-12	2006	Our data suggest that nutlin is an effective radiosensitizer of p53 wild-type cells.	nutlin	22-28	transformation related protein 53, pseudogene	Mus musculus	64-67
19411846-10	2009	Surprisingly, blocking the transcriptional arm of p53, either via alpha-Amanitin or the p53-specific transcriptional inhibitor Pifithrin alpha, not only fails to inhibit, but greatly potentiates Nutlin-induced apoptosis.	nutlin	195-201	tumor protein p53	Homo sapiens	50-53
19411846-10	2009	Surprisingly, blocking the transcriptional arm of p53, either via alpha-Amanitin or the p53-specific transcriptional inhibitor Pifithrin alpha, not only fails to inhibit, but greatly potentiates Nutlin-induced apoptosis.	nutlin	195-201	tumor protein p53	Homo sapiens	88-91
16014563-8	2005	Mechanistic studies suggested that Nutlin-induced apoptosis was mediated by both transcriptional activation of proapoptotic Bcl-2 family proteins, and transcription-independent mitochondrial permeabilization resulting from mitochondrial p53 translocation.	nutlin	35-41	transformation related protein 53	Mus musculus	237-240