PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26887390-3	2016	Four enzymes can catalyze the crucial starting point of the pathway, conversion of fructose-6-phosphate (Fru6P) to glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2).	fructose-6-phosphate	83-103	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	199-210
26887390-3	2016	Four enzymes can catalyze the crucial starting point of the pathway, conversion of fructose-6-phosphate (Fru6P) to glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2).	fructose-6-phosphate	83-103	glucosamine-6-phosphate deaminase 1	Homo sapiens	252-264
26887390-3	2016	Four enzymes can catalyze the crucial starting point of the pathway, conversion of fructose-6-phosphate (Fru6P) to glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2).	fructose-6-phosphate	105-110	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	199-210
26887390-3	2016	Four enzymes can catalyze the crucial starting point of the pathway, conversion of fructose-6-phosphate (Fru6P) to glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2).	fructose-6-phosphate	105-110	glucosamine-6-phosphate deaminase 1	Homo sapiens	252-264
25985179-1	2015	Phosphofructokinase-1 (PFK1), the "gatekeeper" of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate.	fructose-6-phosphate	131-151	phosphofructokinase, muscle	Homo sapiens	0-21
27174229-4	2016	Fructose 6-phosphate, a known enhancer of GKRP action, promotes formation of the initial encounter complex via a 2.6-fold increase in kon and stabilizes the complex through a 60-fold decrease in koff.	fructose-6-phosphate	0-20	glucokinase regulator	Homo sapiens	42-46
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	fructose-6-phosphate	100-120	Phosphofructokinase	Drosophila melanogaster	9-28
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	fructose-6-phosphate	100-120	Phosphofructokinase	Drosophila melanogaster	30-33
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	fructose-6-phosphate	122-125	Phosphofructokinase	Drosophila melanogaster	9-28
26911930-5	2016	METHODS: Phosphofructokinase (PFK) activity was measured in the presence of both of its substrates, fructose-6-phosphate (F6P) and ATP, as well as some allosteric effectors: Fructose- 2,6 - bisphosphate (F2, 6BP), citrate and AMP.	fructose-6-phosphate	122-125	Phosphofructokinase	Drosophila melanogaster	30-33
26629747-3	2016	Moreover, the inhibitory intensity of GKRP-GK is suppressed by fructose 1-phosphate (F1P), and reinforced by fructose 6-phosphate (F6P).	fructose-6-phosphate	109-129	glucokinase regulator	Homo sapiens	38-42
26629747-3	2016	Moreover, the inhibitory intensity of GKRP-GK is suppressed by fructose 1-phosphate (F1P), and reinforced by fructose 6-phosphate (F6P).	fructose-6-phosphate	131-134	glucokinase regulator	Homo sapiens	38-42
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	fructose-6-phosphate	195-215	glucose-6-phosphate isomerase	Homo sapiens	0-29
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	fructose-6-phosphate	195-215	glucose-6-phosphate isomerase	Homo sapiens	31-34
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	fructose-6-phosphate	195-215	glucose-6-phosphate isomerase	Homo sapiens	51-75
26171785-0	2015	Characterization of a Mannose-6-Phosphate Isomerase from Bacillus amyloliquefaciens and Its Application in Fructose-6-Phosphate Production.	fructose-6-phosphate	107-127	mannose-6-phosphate isomerase, class I	Bacillus amyloliquefaciens DSM 7 = ATCC 23350	22-51
25985179-1	2015	Phosphofructokinase-1 (PFK1), the "gatekeeper" of glycolysis, catalyses the committed step of the glycolytic pathway by converting fructose-6-phosphate to fructose-1,6-bisphosphate.	fructose-6-phosphate	131-151	phosphofructokinase, muscle	Homo sapiens	23-27
29124141-1	2015	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate and fructose 6-phosphate in the glycolysis pathway.	fructose-6-phosphate	93-113	glucose-6-phosphate isomerase	Homo sapiens	0-24
29124141-1	2015	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate and fructose 6-phosphate in the glycolysis pathway.	fructose-6-phosphate	93-113	glucose-6-phosphate isomerase	Homo sapiens	26-29
25811607-1	2015	Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	97-117	phosphoglucose isomerase 1	Arabidopsis thaliana	0-24
25811607-1	2015	Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	97-117	phosphoglucose isomerase 1	Arabidopsis thaliana	26-29
24984289-1	2014	This paper describes an innovative amperometric biosensor for the in vitro determination of activity of transketolase from Escherichia coli (TKec) using commercially available TK substrates, namely d-fructose-6-phosphate a physiological donor and glycolaldehyde the best non-phosphorylated acceptor.	fructose-6-phosphate	198-220	transketolase	Homo sapiens	104-117
25104722-2	2014	Thus, the hexose phosphate pools of the cytosol and the chloroplast represent important metabolic resources that are maintained through action of phosphoglucose isomerase (PGI) and phosphoglucose mutase interconverting glucose 6-phosphate, fructose 6-phosphate, and glucose 1-phosphate.	fructose-6-phosphate	240-260	phosphoglucose isomerase 1	Arabidopsis thaliana	172-175
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	fructose-6-phosphate	212-232	ECB2	Homo sapiens	55-58
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	fructose-6-phosphate	212-232	transaldolase 1	Homo sapiens	87-100
25267444-2	2014	Prominent examples are the Schiff-base forming class I FBP and F6P aldolase as well as transaldolase, which all exploit an active center lysine to reversibly cleave the C3-C4 bond of fructose-1,6-bisphosphate or fructose-6-phosphate to give two 3-carbon products (aldolase), or to shuttle 3-carbon units between various phosphosugars (transaldolase).	fructose-6-phosphate	212-232	transaldolase 1	Homo sapiens	335-348
24840038-2	2014	Phosphofructokinase, muscle type (PFKM), is a key regulatory enzyme used to catalyze the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate in glycolysis.	fructose-6-phosphate	116-136	phosphofructokinase, muscle	Sus scrofa	0-39
23957911-4	2013	Formation of the mammalian GCK-GKRP complex is stimulated by fructose 6-phosphate and antagonized by fructose 1-phosphate.	fructose-6-phosphate	61-81	glucokinase	Homo sapiens	27-30
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	88-108	purple acid phosphatase 10	Arabidopsis thaliana	130-137
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	88-108	purple acid phosphatase 12	Arabidopsis thaliana	182-189
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	88-108	purple acid phosphatase 26	Arabidopsis thaliana	233-240
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	110-117	purple acid phosphatase 10	Arabidopsis thaliana	130-137
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	110-117	purple acid phosphatase 12	Arabidopsis thaliana	182-189
24528675-5	2014	On Pi-deficient (P-) medium or P- medium supplemented with the organophosphates ADP and fructose-6-phosphate (Fru-6-P), growth of atpap10 was significantly reduced whereas growth of atpap12 was only moderately reduced, and growth of atpap26 was nearly equal to that of the wild type (WT).	fructose-6-phosphate	110-117	purple acid phosphatase 26	Arabidopsis thaliana	233-240
24528675-6	2014	Overexpression of the AtPAP12 or AtPAP26 gene, however, caused plants to grow better on P- or P- medium supplemented with ADP or Fru-6-P.	fructose-6-phosphate	129-136	purple acid phosphatase 12	Arabidopsis thaliana	22-29
24528675-6	2014	Overexpression of the AtPAP12 or AtPAP26 gene, however, caused plants to grow better on P- or P- medium supplemented with ADP or Fru-6-P.	fructose-6-phosphate	129-136	purple acid phosphatase 26	Arabidopsis thaliana	33-40
25041126-8	2014	Nrf1 repressed insulin-regulated glycolysis-related gene expression and gave rise to loss of glucose-6-phosphate and fructose-6-phosphate contents in liver.	fructose-6-phosphate	117-137	nuclear factor, erythroid derived 2,-like 1	Mus musculus	0-4
24075873-1	2014	The enzyme glucosamine-6P Synthase (Gfat, L-glutamine:D-fructose-6P amidotransferase) is involved in the hexosamine biosynthetic pathway and catalyzes the formation of glucosamine-6P from the substrates d-fructose-6-phosphate and l-glutamine.	fructose-6-phosphate	203-225	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	36-40
24063558-2	2013	Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), the enzyme that catalyses the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate in glucose metabolism, in gastric cancer (GC) development.	fructose-6-phosphate	155-175	fructose-bisphosphatase 2	Homo sapiens	44-73
24063558-2	2013	Here, we investigated the potential role of fructose-1,6-bisphosphatase-2 (FBP2), the enzyme that catalyses the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate in glucose metabolism, in gastric cancer (GC) development.	fructose-6-phosphate	155-175	fructose-bisphosphatase 2	Homo sapiens	75-79
23957911-4	2013	Formation of the mammalian GCK-GKRP complex is stimulated by fructose 6-phosphate and antagonized by fructose 1-phosphate.	fructose-6-phosphate	61-81	glucokinase regulator	Homo sapiens	31-35
23957911-5	2013	Here we report the crystal structure of the mammalian GCK-GKRP complex in the presence of fructose 6-phosphate at a resolution of 3.50 A.	fructose-6-phosphate	90-110	glucokinase	Homo sapiens	54-57
23957911-5	2013	Here we report the crystal structure of the mammalian GCK-GKRP complex in the presence of fructose 6-phosphate at a resolution of 3.50 A.	fructose-6-phosphate	90-110	glucokinase regulator	Homo sapiens	58-62
23825378-1	2013	Glucose phosphate isomerase (GPI) involves in the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate in glucose pathways.	fructose-6-phosphate	101-121	glucose-6-phosphate isomerase	Gallus gallus	0-27
23825378-1	2013	Glucose phosphate isomerase (GPI) involves in the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate in glucose pathways.	fructose-6-phosphate	101-121	glucose-6-phosphate isomerase	Gallus gallus	29-32
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	189-209	phosphomannomutase 2	Homo sapiens	98-122
23389994-5	2013	TARDBP regulates expression of the platelet isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.	fructose-6-phosphate	168-188	TAR DNA binding protein	Homo sapiens	0-6
23389994-5	2013	TARDBP regulates expression of the platelet isoform of phosphofructokinase (PFKP), the rate-limiting enzyme of glycolysis that catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.	fructose-6-phosphate	168-188	phosphofructokinase, platelet	Homo sapiens	76-80
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase regulator	Homo sapiens	0-30
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase regulator	Homo sapiens	32-36
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase	Homo sapiens	53-64
23307301-1	2013	Glucokinase regulatory protein (GCKR) which binds to glucokinase (GCK) in the nucleus and inhibits its activity in the presence of fructose-6-phosphate is critical for glucose metabolism.	fructose-6-phosphate	131-151	glucokinase	Homo sapiens	32-35
23621087-3	2013	GKRP in turn is activated by fructose 6-phosphate (F6P) and inactivated by fructose 1-phosphate (F1P).	fructose-6-phosphate	29-49	glucokinase regulator	Homo sapiens	0-4
23621087-3	2013	GKRP in turn is activated by fructose 6-phosphate (F6P) and inactivated by fructose 1-phosphate (F1P).	fructose-6-phosphate	51-54	glucokinase regulator	Homo sapiens	0-4
22899857-3	2013	Synthesis of the lipid-linked oligosaccharide (LLO), which serves as the sugar donor for the N-glycosylation of secretory proteins, requires conversion of fructose-6-phosphate to mannose-6-phosphate via the phosphomannose isomerase (MPI) enzyme.	fructose-6-phosphate	155-175	mannose phosphate isomerase	Homo sapiens	233-236
22699485-3	2012	Glucose phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	100-120	glucose-6-phosphate isomerase	Gallus gallus	0-27
22699485-3	2012	Glucose phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	100-120	glucose-6-phosphate isomerase	Gallus gallus	29-32
22846316-4	2012	Mannose-6 phosphate is a natural inhibitor of TGF-ss and can also is converted to fructose 6 phosphate which we have shown is capable of reducing HIF-1 a.	fructose-6-phosphate	82-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-153
21683706-1	2011	Phosphomannose isomerase (PMI) catalyzes the reversible interconversion of fructose 6-phosphate (Fru-6-P) and mannose 6-phosphate (Man-6-P), providing a link between glycolysis and the mannose metabolic pathway.	fructose-6-phosphate	75-95	mannose phosphate isomerase	Homo sapiens	0-24
21683706-1	2011	Phosphomannose isomerase (PMI) catalyzes the reversible interconversion of fructose 6-phosphate (Fru-6-P) and mannose 6-phosphate (Man-6-P), providing a link between glycolysis and the mannose metabolic pathway.	fructose-6-phosphate	75-95	mannose phosphate isomerase	Homo sapiens	26-29
21683706-1	2011	Phosphomannose isomerase (PMI) catalyzes the reversible interconversion of fructose 6-phosphate (Fru-6-P) and mannose 6-phosphate (Man-6-P), providing a link between glycolysis and the mannose metabolic pathway.	fructose-6-phosphate	97-104	mannose phosphate isomerase	Homo sapiens	0-24
21683706-1	2011	Phosphomannose isomerase (PMI) catalyzes the reversible interconversion of fructose 6-phosphate (Fru-6-P) and mannose 6-phosphate (Man-6-P), providing a link between glycolysis and the mannose metabolic pathway.	fructose-6-phosphate	97-104	mannose phosphate isomerase	Homo sapiens	26-29
23733961-4	2013	We determined the crystal structure of Xenopus GK and GKRP complex in the presence of fructose-6-phosphate at 2.9 A.	fructose-6-phosphate	86-106	glucokinase regulator L homeolog	Xenopus laevis	54-58
22213537-1	2012	Kinetic analysis of PFK-1 from rodent AS-30D, and human HeLa and MCF-7 carcinomas revealed sigmoidal [fructose 6-phosphate, Fru6P]-rate curves with different V(m) values when varying the allosteric activator fructose 2,6 bisphosphate (Fru2,6BP), AMP, Pi, NH(4)(+), or K(+).	fructose-6-phosphate	102-122	phosphofructokinase, muscle	Homo sapiens	20-25
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	211-218	phosphomannomutase 2	Homo sapiens	98-122
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	211-218	phosphomannomutase 2	Homo sapiens	124-127
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	189-209	phosphomannomutase 2	Homo sapiens	124-127
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	189-209	phosphomannomutase 2	Homo sapiens	257-277
21539312-1	2011	We report the discovery and validation of a series of benzoisothiazolones as potent inhibitors of phosphomannose isomerase (PMI), an enzyme that converts mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) and, more importantly, competes with phosphomannomutase 2 (PMM2) for Man-6-P, diverting this substrate from critical protein glycosylation events.	fructose-6-phosphate	189-209	phosphomannomutase 2	Homo sapiens	279-283
20208175-1	2010	Phosphoglucose isomerase (PGI) is a key enzyme in glycolysis and glycogenesis that catalyses the interconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	146-166	glucose-6-phosphate isomerase	Homo sapiens	26-29
21241708-1	2011	Phosphofructokinase 1 (PFK) is a multisubunit allosteric enzyme that catalyzes the principal regulatory step in glycolysis-the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate by ATP.	fructose-6-phosphate	146-166	ATP-dependent 6-phosphofructokinase, platelet type	Oryctolagus cuniculus	0-21
21241708-1	2011	Phosphofructokinase 1 (PFK) is a multisubunit allosteric enzyme that catalyzes the principal regulatory step in glycolysis-the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate by ATP.	fructose-6-phosphate	146-166	ATP-dependent 6-phosphofructokinase, platelet type	Oryctolagus cuniculus	23-26
22039417-1	2011	FBP1, fructose-1,6-bisphosphatase-1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.	fructose-6-phosphate	131-151	fructose-bisphosphatase 1	Homo sapiens	0-4
22039417-1	2011	FBP1, fructose-1,6-bisphosphatase-1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.	fructose-6-phosphate	131-151	fructose-bisphosphatase 1	Homo sapiens	6-35
20826560-4	2010	Here, we show that fructose-6-phosphate (F6P) can substitute for G6P and is sufficient to maintain reductase activity of 11beta-HSD1 in isolated microsomes.	fructose-6-phosphate	19-39	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	121-132
20826560-4	2010	Here, we show that fructose-6-phosphate (F6P) can substitute for G6P and is sufficient to maintain reductase activity of 11beta-HSD1 in isolated microsomes.	fructose-6-phosphate	41-44	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	121-132
20208175-1	2010	Phosphoglucose isomerase (PGI) is a key enzyme in glycolysis and glycogenesis that catalyses the interconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	168-171	glucose-6-phosphate isomerase	Homo sapiens	26-29
20103683-8	2010	Overexpression of TKTL1 increased the production of fructose-6-phosphate and glyceraldehyde-3-phosphate, in turn elevating the production of pyruvate and lactate, resulting in the normoxic stabilization of the malignancy-promoting transcription factor HIF1alpha and the upregulation of downstream glycolytic enzymes.	fructose-6-phosphate	52-72	transketolase like 1	Homo sapiens	18-23
19247671-2	2009	In mammals, GCK is regulated in vivo by a regulatory protein (GCKR) through a nucleus-to-cytoplasm translocation enhanced by fructose 1-phosphate and counteracted by fructose 6-phosphate.	fructose-6-phosphate	166-186	glucokinase	Rattus norvegicus	12-15
19780152-4	2009	These differences reflect the exchange of the carbon 4, 5, and 6 moiety of fructose-6-phosphate and glyceraldehyde-3-phosphate catalyzed by transaldolase.	fructose-6-phosphate	75-95	transaldolase 1	Homo sapiens	140-153
19671048-1	2009	Mammalian GKRP [GK (glucokinase) regulatory protein], a fructose 6-phosphate and fructose 1-phosphate sensitive inhibitor of GK, appears to have resulted from the duplication of a gene similar to bacterial N-acetylmuramate 6-phosphate etherase MurQ.	fructose-6-phosphate	56-76	glucokinase regulator L homeolog	Xenopus laevis	10-14
19671048-5	2009	The etherase activity of rat GKRP was inhibited by ligands (fructose 6-phosphate, fructose 1-phosphate and sorbitol 6-phosphate) known to regulate its interaction with GK and by mutations affecting the binding of these phosphate esters.	fructose-6-phosphate	60-80	glucokinase regulator L homeolog	Xenopus laevis	29-33
19574302-1	2009	Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P).	fructose-6-phosphate	112-132	mannose phosphate isomerase	Homo sapiens	0-24
19574302-1	2009	Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P).	fructose-6-phosphate	112-132	mannose phosphate isomerase	Homo sapiens	26-29
19574302-1	2009	Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P).	fructose-6-phosphate	134-141	mannose phosphate isomerase	Homo sapiens	0-24
19574302-1	2009	Phosphomannose isomerase (PMI) is an enzyme catalysing the interconversion of mannose 6-phosphate (Man-6-P) and fructose 6-phosphate (Fru-6-P).	fructose-6-phosphate	134-141	mannose phosphate isomerase	Homo sapiens	26-29
19574302-4	2009	Characterization of A. fumigatus Pmi1 expressed in Escherichia coli revealed that this PMI mainly catalysed the conversion of Fru-6-P to Man-6-P and that its binding affinity for Man-6-P was similar to that of yeast PMIs, but different to those of PMIs from bacteria or animals.	fructose-6-phosphate	126-133	mannose phosphate isomerase	Homo sapiens	33-37
19574302-4	2009	Characterization of A. fumigatus Pmi1 expressed in Escherichia coli revealed that this PMI mainly catalysed the conversion of Fru-6-P to Man-6-P and that its binding affinity for Man-6-P was similar to that of yeast PMIs, but different to those of PMIs from bacteria or animals.	fructose-6-phosphate	126-133	mannose phosphate isomerase	Homo sapiens	87-90
19473963-3	2009	The concentration of Fru-2,6-BP in mammalian cells is set by four 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4), which interconvert fructose 6-phosphate and Fru-2,6-BP.	fructose-6-phosphate	151-171	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Homo sapiens	121-129
19401148-2	2009	The nearly ubiquitous enzyme transaldolase is a part of the pentose phosphate pathway and transfers a dihydroxyacetone group from donor compounds (fructose 6-phosphate or sedoheptulose 7-phosphate) to aldehyde acceptor compounds.	fructose-6-phosphate	147-167	transaldolase 1	Homo sapiens	29-42
19889875-8	2010	By contrast, the binding of two other maize AGPase allosteric activators (fructose-6-phosphate and glucose-6-phosphate) did not always mimic the changes observed for 3-PGA.	fructose-6-phosphate	74-94	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	44-50
19807849-6	2009	Furthermore, coprecipitation of GK and GKRP in the presence of fructose 6-phosphate suggests interactions between both proteins.	fructose-6-phosphate	63-83	glucokinase	Rattus norvegicus	32-34
19807849-6	2009	Furthermore, coprecipitation of GK and GKRP in the presence of fructose 6-phosphate suggests interactions between both proteins.	fructose-6-phosphate	63-83	glucokinase regulator	Rattus norvegicus	39-43
19247671-2	2009	In mammals, GCK is regulated in vivo by a regulatory protein (GCKR) through a nucleus-to-cytoplasm translocation enhanced by fructose 1-phosphate and counteracted by fructose 6-phosphate.	fructose-6-phosphate	166-186	glucokinase regulator	Rattus norvegicus	62-66
18809676-4	2008	In the presence of fructose-6-phosphate, GK-GKRP complex formation displayed a strong entropic driving force opposed by a large positive enthalpy; a negative change in heat capacity was observed (Kd = 45 nm, DeltaH = 15.6 kcal/mol, TDeltaS = 25.7 kcal/mol, DeltaCp = -354 cal mol(-1) K(-1)).	fructose-6-phosphate	19-39	glucokinase regulator	Homo sapiens	44-48
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase b	Danio rerio	0-29
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase b	Danio rerio	31-34
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase a	Danio rerio	57-81
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase a	Danio rerio	83-86
19064002-1	2009	Glucose-6-phosphate isomerase (GPI), a homodimeric enzyme, catalyzes the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	121-141	glucose-6-phosphate isomerase	Homo sapiens	0-29
19064002-1	2009	Glucose-6-phosphate isomerase (GPI), a homodimeric enzyme, catalyzes the interconversion between glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	121-141	glucose-6-phosphate isomerase	Homo sapiens	31-34
19014931-7	2008	Consistent with the inhibition of FBPase, glucose-lowering was associated with an accumulation of hepatic d-fructose 1,6-bisphosphate and a reduction in hepatic d-fructose 6-phosphate.	fructose-6-phosphate	161-183	fructose-bisphosphatase 2	Rattus norvegicus	34-40
18687684-1	2008	Based on a structure-assisted sequence alignment we designed 11 focused libraries at residues in the active site of transaldolase B from Escherichia coli and screened them for their ability to synthesize fructose 6-phosphate from dihydroxyacetone and glyceraldehyde 3-phosphate using a newly developed color assay.	fructose-6-phosphate	204-224	transaldolase 1	Homo sapiens	116-129
18581039-4	2008	In particular, TK is able to shift excess fructose-6-phosphate and glycerhaldeyde-3-phosphate from glycolysis into the pentose-phosphate shunt, thus eliminating these potentially damaging metabolites from the cytosol.	fructose-6-phosphate	42-62	transketolase	Homo sapiens	15-17
18755683-1	2008	We studied molecular and functional properties of Arabidopsis phosphomannose isomerase isoenzymes (PMI1 and PMI2) that catalyze reversible isomerization between D-fructose 6-phosphate and D-mannose 6-phosphate (Man-6P).	fructose-6-phosphate	161-183	plastid movement impaired1	Arabidopsis thaliana	99-103
18755683-1	2008	We studied molecular and functional properties of Arabidopsis phosphomannose isomerase isoenzymes (PMI1 and PMI2) that catalyze reversible isomerization between D-fructose 6-phosphate and D-mannose 6-phosphate (Man-6P).	fructose-6-phosphate	161-183	PLASTID MOVEMENT IMPAIRED protein (DUF827)	Arabidopsis thaliana	108-112
18928705-4	2008	PMI catalyzes the interconversion of fructose-6-P and mannose-6-P.	fructose-6-phosphate	37-49	mannose phosphate isomerase	Homo sapiens	0-3
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase	Homo sapiens	32-35
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase regulator	Homo sapiens	188-218
18556336-1	2008	OBJECTIVE: Hepatic glucokinase (GCK) is a key regulator of glucose storage and disposal in the liver, where its activity is competitively modulated, with respect to glucose, by binding to glucokinase regulatory protein (GCKR) in the presence of fructose 6-phosphate.	fructose-6-phosphate	245-265	glucokinase regulator	Homo sapiens	220-224
17643314-1	2007	Phosphofructokinase (Pfk1; EC 2.7.1.11) is the third enzyme of the glycolytic pathway catalyzing the formation of fructose-1,6-bisphosphate from fructose-6-phosphate (F6P) and ATP.	fructose-6-phosphate	145-165	phosphofructokinase, muscle	Homo sapiens	21-25
18053578-3	2008	In this article we describe the coupling of a transketolase reaction (using Leishmania mexicana transketolase) that converts D-fructose 6-phosphate to D-erythrose 4-phosphate.	fructose-6-phosphate	125-147	transketolase	Homo sapiens	46-59
18053578-3	2008	In this article we describe the coupling of a transketolase reaction (using Leishmania mexicana transketolase) that converts D-fructose 6-phosphate to D-erythrose 4-phosphate.	fructose-6-phosphate	125-147	transketolase	Homo sapiens	96-109
18215164-3	2008	Imported or salvaged mannose is directly phosphorylated by hexokinase, whereas fructose 6-phosphate from glucose is converted to mannose 6-phosphate by phosphomannose isomerase (PMI).	fructose-6-phosphate	79-99	mannose phosphate isomerase	Mus musculus	152-176
18215164-3	2008	Imported or salvaged mannose is directly phosphorylated by hexokinase, whereas fructose 6-phosphate from glucose is converted to mannose 6-phosphate by phosphomannose isomerase (PMI).	fructose-6-phosphate	79-99	mannose phosphate isomerase	Mus musculus	178-181
17914867-0	2007	Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.	fructose-6-phosphate	188-208	transketolase	Homo sapiens	110-123
18550363-5	2008	Fructose-6-phosphate increased the activity of 11beta-HSD1 reductase in isolated rat and porcine liver microsomes but not porcine fat microsomes.	fructose-6-phosphate	0-20	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	47-58
18424616-1	2008	Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6"-phosphate (S6P).	fructose-6-phosphate	179-201	decaprenyl diphosphate synthase subunit 1	Homo sapiens	0-26
18424616-1	2008	Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6"-phosphate (S6P).	fructose-6-phosphate	179-201	decaprenyl diphosphate synthase subunit 1	Homo sapiens	28-31
18424616-1	2008	Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6"-phosphate (S6P).	fructose-6-phosphate	203-206	decaprenyl diphosphate synthase subunit 1	Homo sapiens	0-26
18424616-1	2008	Sucrose phosphate synthase (SPS) catalyzes the transfer of a glycosyl group from an activated donor sugar, such as uridine diphosphate glucose (UDP-Glc), to a saccharide acceptor D-fructose 6-phosphate (F6P), resulting in the formation of UDP and D-sucrose-6"-phosphate (S6P).	fructose-6-phosphate	203-206	decaprenyl diphosphate synthase subunit 1	Homo sapiens	28-31
17914867-2	2007	The X-ray structures of transketolase from E. coli in a covalent complex with donor ketoses d-xylulose 5-phosphate (X5P) and d-fructose 6-phosphate (F6P) at 1.47 A and 1.65 A resolution reveal significant strain in the tetrahedral cofactor-sugar adducts with a 25-30 degrees out-of-plane distortion of the C2-Calpha bond connecting the substrates" carbonyl with the C2 of the cofactor"s thiazolium part.	fructose-6-phosphate	125-147	transketolase	Homo sapiens	24-37
17914867-2	2007	The X-ray structures of transketolase from E. coli in a covalent complex with donor ketoses d-xylulose 5-phosphate (X5P) and d-fructose 6-phosphate (F6P) at 1.47 A and 1.65 A resolution reveal significant strain in the tetrahedral cofactor-sugar adducts with a 25-30 degrees out-of-plane distortion of the C2-Calpha bond connecting the substrates" carbonyl with the C2 of the cofactor"s thiazolium part.	fructose-6-phosphate	149-152	transketolase	Homo sapiens	24-37
17643314-1	2007	Phosphofructokinase (Pfk1; EC 2.7.1.11) is the third enzyme of the glycolytic pathway catalyzing the formation of fructose-1,6-bisphosphate from fructose-6-phosphate (F6P) and ATP.	fructose-6-phosphate	167-170	phosphofructokinase, muscle	Homo sapiens	21-25
17229526-3	2007	At physiological pH, S. aurata PFKM exhibited sigmoidal kinetics for the substrates, fructose-6-phosphate (fru-6-P) and ATP.	fructose-6-phosphate	85-105	phosphofructokinase, muscle	Homo sapiens	31-35
17640273-4	2007	Specifically, mutations and conditions resulting in fructose-6-phosphate (F-6-P) accumulation elicit superinduction of uspA upon carbon starvation, whereas genetic manipulations reducing the pool size of F-6-P have the opposite effect.	fructose-6-phosphate	52-72	putative universal stress protein UspA	Escherichia coli	119-123
17640273-4	2007	Specifically, mutations and conditions resulting in fructose-6-phosphate (F-6-P) accumulation elicit superinduction of uspA upon carbon starvation, whereas genetic manipulations reducing the pool size of F-6-P have the opposite effect.	fructose-6-phosphate	74-79	putative universal stress protein UspA	Escherichia coli	119-123
17493831-4	2007	Saccharomyces cerevisiae Pfk1 is an 835 kDa hetero-octamer which shows cooperative binding for fructose-6-phosphate (F6P) and non-cooperative binding for ATP.	fructose-6-phosphate	95-115	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	25-29
17493831-4	2007	Saccharomyces cerevisiae Pfk1 is an 835 kDa hetero-octamer which shows cooperative binding for fructose-6-phosphate (F6P) and non-cooperative binding for ATP.	fructose-6-phosphate	117-120	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	25-29
17661163-4	2007	A key step in controlling glycolytic rate is the conversion of fructose-6-P to fructose-1,6-P(2) by 6-phosphofructo-1-kinase (PFK-1).	fructose-6-phosphate	63-75	phosphofructokinase, muscle	Homo sapiens	126-131
17229526-3	2007	At physiological pH, S. aurata PFKM exhibited sigmoidal kinetics for the substrates, fructose-6-phosphate (fru-6-P) and ATP.	fructose-6-phosphate	107-114	phosphofructokinase, muscle	Homo sapiens	31-35
17229526-4	2007	Fructose-2,6-bisphosphate (fru-2,6-P(2)) converted the saturation curves for fru-6-P to hyperbolic, activated PFKM synergistically with other positive effectors of the enzyme such as AMP and ADP, and counteracted ATP and citrate inhibition.	fructose-6-phosphate	77-84	phosphofructokinase, muscle	Homo sapiens	110-114
16860376-2	2006	A truly bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PFK2/FBP2), with two active sites synthesizes F26P2 from fructose-6-phosphate (F6P) and ATP or degrades F26P2 to F6P and Pi.	fructose-6-phosphate	141-161	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	29-81
17126561-1	2007	Phosphoglucose isomerase (PGI) EC 5.3.1.9, is a housekeeping enzyme that catalyzes the reversible isomerization of d-glucopyranose-6-phosphate and d-fructofuranose-6-phosphate.	fructose-6-phosphate	147-175	glucose-6-phosphate isomerase	Mycobacterium tuberculosis H37Rv	0-24
17126561-1	2007	Phosphoglucose isomerase (PGI) EC 5.3.1.9, is a housekeeping enzyme that catalyzes the reversible isomerization of d-glucopyranose-6-phosphate and d-fructofuranose-6-phosphate.	fructose-6-phosphate	147-175	glucose-6-phosphate isomerase	Mycobacterium tuberculosis H37Rv	26-29
16565859-1	2006	The selectable marker system, which utilizes the pmi gene encoding for phosphomannose-isomerase that converts mannose-6-phosphate to fructose-6-phosphate, was adapted for Agrobacterium-mediated transformation of cucumber (Cucumis sativus L.).	fructose-6-phosphate	133-153	mannose-6-phosphate isomerase 1	Cucumis sativus	71-95
17178593-2	2006	We have previously demonstrated that some of the effects of high glucose on mesangial extracellular matrix (ECM) protein expression are mediated by the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosamine-6-phosphate by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).	fructose-6-phosphate	199-219	glutamine fructose-6-phosphate transaminase 1	Mus musculus	288-335
17178593-2	2006	We have previously demonstrated that some of the effects of high glucose on mesangial extracellular matrix (ECM) protein expression are mediated by the hexosamine biosynthesis pathway (HBP) in which fructose-6-phosphate is converted to glucosamine-6-phosphate by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).	fructose-6-phosphate	199-219	glutamine fructose-6-phosphate transaminase 1	Mus musculus	337-341
16339137-1	2006	MPI encodes phosphomannose isomerase, which interconverts fructose 6-phosphate and mannose 6-phosphate (Man-6-P), used for glycoconjugate biosynthesis.	fructose-6-phosphate	58-78	mannose phosphate isomerase	Mus musculus	12-36
16475835-1	2006	Phosphofructokinase (PFK) catalyzes the phosphorylation of fructose 6-phosphate (F6P) to give fructose 1,6-bisphosphate (FBP) using MgATP as the phosphoryl donor.	fructose-6-phosphate	59-79	fructose-bisphosphatase 1	Homo sapiens	121-124
16860376-2	2006	A truly bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (6PFK2/FBP2), with two active sites synthesizes F26P2 from fructose-6-phosphate (F6P) and ATP or degrades F26P2 to F6P and Pi.	fructose-6-phosphate	141-161	fructose-bisphosphatase 2	Homo sapiens	89-93
16339923-2	2006	Fructose 6-phosphate is converted to glucosamine 6-phosphate, catalyzed by the first and rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).	fructose-6-phosphate	0-20	glutamine fructose-6-phosphate transaminase 1	Mus musculus	110-157
16339923-2	2006	Fructose 6-phosphate is converted to glucosamine 6-phosphate, catalyzed by the first and rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).	fructose-6-phosphate	0-20	glutamine fructose-6-phosphate transaminase 1	Mus musculus	159-163
16212940-10	2005	The K(m) of rPGI was determined to be 0.318 mM for fructose-6-phosphate and the K(i) was 0.8 mM for 6-phosphogluconate.	fructose-6-phosphate	51-71	glucose-6-phosphate isomerase	Rattus norvegicus	12-16
16277773-5	2005	Also, at this same point, liver xylulose-5-phosphate, a key stimulator of glycolysis, the ratio of fructose-1,6-bisphosphate to fructose-6-phosphate in skeletal muscle, which reflects phosphofructokinase-1 activity, and liver malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl-transferase, were significantly lower in the acetic acid group than in the control group (P<0.05).	fructose-6-phosphate	128-148	phosphofructokinase, liver type	Rattus norvegicus	184-205
16269670-7	2005	This conclusion was supported by measurements of sugar phosphates, which showed that there were increased concentrations of glucose-6-phosphate, galactose-6-phosphate, and fructose-6-phosphate in the strain construct overexpressing PGM2.	fructose-6-phosphate	172-192	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	232-236
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	fructose-6-phosphate	94-116	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
16131071-1	2005	Electrospray ionization Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry was used to study the noncovalent complexation of a metalloenzyme, phosphomannose isomerase (PMI), which catalyzes the interconversion of mannose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	258-278	mannose phosphate isomerase	Homo sapiens	163-187
16131071-1	2005	Electrospray ionization Fourier transform ion cyclotron resonance (ESI-FTICR) mass spectrometry was used to study the noncovalent complexation of a metalloenzyme, phosphomannose isomerase (PMI), which catalyzes the interconversion of mannose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	258-278	mannose phosphate isomerase	Homo sapiens	189-192
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	fructose-6-phosphate	94-116	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
15689508-2	2005	Analysis of previously reported X-ray crystal structures of PGI without ligand, with the cyclic form of F6P, or with inhibitors that mimic the cis-enediol intermediate led to proposed mechanisms for the ring opening and isomerization steps in the multistep catalytic mechanism.	fructose-6-phosphate	104-107	glucose-6-phosphate isomerase	Oryctolagus cuniculus	60-63
15689508-5	2005	As was seen in the PGI/F6P structure, a helix containing amino acid residues 512-520 is found in the "out" position, which provides sufficient space in the active site for a substrate in its cyclic form and which is probably the location of that helix just after ring opening (or just before ring closure).	fructose-6-phosphate	23-26	glucose-6-phosphate isomerase	Oryctolagus cuniculus	19-22
15646042-5	2004	Analysis of the kinetic parameters revealed that the regulation of 6-phosphofructo 1-kinase is altered in infected cells, presenting an increase in Vmax along with a decrease in Km for fructose-6-phosphate.	fructose-6-phosphate	185-205	phosphofructokinase, muscle	Homo sapiens	67-91
15520001-1	2004	Phosphomannose isomerase (PMI40) catalyzes the conversion between fructose 6-phosphate and mannose 6-phosphate and thus connects glycolysis, i.e. energy production and GDP-mannose biosynthesis or cell wall synthesis in Saccharomyces cerevisiae.	fructose-6-phosphate	66-86	mannose-6-phosphate isomerase PMI40	Saccharomyces cerevisiae S288C	26-31
15133036-4	2004	The Km values for the two substrates of reaction, fructose 6-phosphate and glutamine, were determined to be 0.8 mm for fructose 6-phosphate and 1.2 mm for glutamine, which are within the ranges determined for GFAT1.	fructose-6-phosphate	50-70	glutamine fructose-6-phosphate transaminase 1	Mus musculus	209-214
15342241-1	2004	Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine.	fructose-6-phosphate	107-127	glucose-6-phosphate isomerase 1	Mus musculus	0-24
15342241-1	2004	Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine.	fructose-6-phosphate	107-127	glucose-6-phosphate isomerase 1	Mus musculus	26-29
15342241-8	2004	To isomerize M6P to F6P requires a rotation of its C2-C3 bond but in PGI this is sterically blocked by Gln511.	fructose-6-phosphate	20-23	glucose-6-phosphate isomerase 1	Mus musculus	69-72
15133036-4	2004	The Km values for the two substrates of reaction, fructose 6-phosphate and glutamine, were determined to be 0.8 mm for fructose 6-phosphate and 1.2 mm for glutamine, which are within the ranges determined for GFAT1.	fructose-6-phosphate	119-139	glutamine fructose-6-phosphate transaminase 1	Mus musculus	209-214
15150374-8	2004	This cluster of gluconeogenic enzymes and their common metabolic intermediate fructose-6-phosphate may regulate fructose metabolism and GLUT5 expression in the small intestine.	fructose-6-phosphate	78-98	solute carrier family 2 member 5	Rattus norvegicus	136-141
14627435-3	2004	Human GKRP is a more potent inhibitor of glucokinase than rat GKRP in the absence of fructose 6-phosphate or sorbitol 6-phosphate, and has a higher affinity for these ligands.	fructose-6-phosphate	85-105	glucokinase regulator	Homo sapiens	6-10
15165751-5	2004	The suitable concentrations of the reactants fructose-6-phosphate (F-6-P), glutamine, acetylpyridine adenine dinucleotide (APAD) and glutamate dehydrogenase (GDH) were 0.8, 6 and 0.3 mM and 6 U, respectively.	fructose-6-phosphate	45-65	glutamate dehydrogenase 1	Homo sapiens	158-161
15103138-1	2004	Glucose-6-phosphate isomerase (PGI; EC 5.3.1.9; also often called by its old nomenclature phosphoglucose isomerase) is an intracellular enzyme that catalyses the reversible conversion of D-glucose 6-phosphate (G6P) to D-fructose 6-phosphate (F6P).	fructose-6-phosphate	218-240	glucose-6-phosphate isomerase	Homo sapiens	31-34
15103138-1	2004	Glucose-6-phosphate isomerase (PGI; EC 5.3.1.9; also often called by its old nomenclature phosphoglucose isomerase) is an intracellular enzyme that catalyses the reversible conversion of D-glucose 6-phosphate (G6P) to D-fructose 6-phosphate (F6P).	fructose-6-phosphate	242-245	glucose-6-phosphate isomerase	Homo sapiens	31-34
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	fructose-6-phosphate	121-141	glucose-6-phosphate isomerase	Homo sapiens	0-24
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	fructose-6-phosphate	121-141	glucose-6-phosphate isomerase	Homo sapiens	25-50
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	fructose-6-phosphate	121-141	glucose-6-phosphate isomerase	Homo sapiens	52-55
14997475-4	2004	Unproblematic detectability of hexokinase and phosphofructokinase demonstrates that the selectivity of synthetic multifunctional pore (SMPs) sensors suffices to sense ATP in mixed analytes containing ADP, whereas detection of the isomerization of glucose 6-phosphate into fructose 6-phosphate by phosphoglucose isomerase is not possible with confidence.	fructose-6-phosphate	272-292	hexokinase 1	Homo sapiens	31-41
12580319-3	2003	This pathway converts fructose-6-phosphate to glucosamine (GlcN)-6-phosphate by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	22-42	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	105-152
14586688-1	2003	A simultaneous quantification system of ionic dissociative metabolites was developed using a Fourier transform mid-infrared spectroscopic method by focusing our attention on the enzyme reaction from glucose 6-phosphate to fructose 6-phosphate with phosphoglucose isomerase (PGI).	fructose-6-phosphate	222-242	glucose-6-phosphate isomerase	Homo sapiens	248-272
14586688-1	2003	A simultaneous quantification system of ionic dissociative metabolites was developed using a Fourier transform mid-infrared spectroscopic method by focusing our attention on the enzyme reaction from glucose 6-phosphate to fructose 6-phosphate with phosphoglucose isomerase (PGI).	fructose-6-phosphate	222-242	glucose-6-phosphate isomerase	Homo sapiens	274-277
12777791-1	2003	Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	123-143	glucose-6-phosphate isomerase	Homo sapiens	0-24
12777791-1	2003	Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	123-143	glucose-6-phosphate isomerase	Homo sapiens	26-29
12616532-1	2003	The enzyme, glucosamine-6-phosphate isomerase (GNPI) or deaminase (GNPDA) (EC 5.3.1.10), catalyzes the conversion of GNP to fructose-6-phosphate and ammonia, with an aldo/keto isomerization and an amination/deamination.	fructose-6-phosphate	124-144	glucosamine-6-phosphate deaminase 1	Homo sapiens	12-45
12616532-1	2003	The enzyme, glucosamine-6-phosphate isomerase (GNPI) or deaminase (GNPDA) (EC 5.3.1.10), catalyzes the conversion of GNP to fructose-6-phosphate and ammonia, with an aldo/keto isomerization and an amination/deamination.	fructose-6-phosphate	124-144	glucosamine-6-phosphate deaminase 1	Homo sapiens	47-51
12616532-1	2003	The enzyme, glucosamine-6-phosphate isomerase (GNPI) or deaminase (GNPDA) (EC 5.3.1.10), catalyzes the conversion of GNP to fructose-6-phosphate and ammonia, with an aldo/keto isomerization and an amination/deamination.	fructose-6-phosphate	124-144	glucosamine-6-phosphate deaminase 1	Homo sapiens	67-72
12616532-10	2003	Like GNPI, the recombinant GNPI2 has been proved to have the enzymatic activity to catalyze the conversion of GNP to fructose-6-phosphate.	fructose-6-phosphate	117-137	glucosamine-6-phosphate deaminase 1	Homo sapiens	5-9
12739015-9	2003	Mutation Arg518Gln, replacing a conserved residue, led to a marked decrease in the affinity of GKRP for both fructose 6-phosphate and fructose 1-phosphate and to a destabilization of GKRP.	fructose-6-phosphate	109-129	glucokinase regulator	Homo sapiens	95-99
12595702-1	2003	Phosphoglucose isomerase (PGI) is a housekeeping enzyme of metabolism that catalyses the interconversion of glucose 6-phosphate and fructose 6-phosphate, with roles in the glycolytic and gluconeogenic pathways.	fructose-6-phosphate	132-152	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12595702-1	2003	Phosphoglucose isomerase (PGI) is a housekeeping enzyme of metabolism that catalyses the interconversion of glucose 6-phosphate and fructose 6-phosphate, with roles in the glycolytic and gluconeogenic pathways.	fructose-6-phosphate	132-152	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
12595702-4	2003	Comparison with published structures of rabbit PGI in complex with three inhibitors and with the substrate fructose 6-phosphate reveals a number of conformational changes that may be associated with catalytic function.	fructose-6-phosphate	107-127	glucose-6-phosphate isomerase	Oryctolagus cuniculus	47-50
12580319-3	2003	This pathway converts fructose-6-phosphate to glucosamine (GlcN)-6-phosphate by the rate-limiting enzyme glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	22-42	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	154-157
12368100-1	2002	Phosphoglucose isomerase (PGI; EC 5.3.1.9) is the second enzyme in glycolysis, where it catalyzes the isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate.	fructose-6-phosphate	144-166	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12368100-1	2002	Phosphoglucose isomerase (PGI; EC 5.3.1.9) is the second enzyme in glycolysis, where it catalyzes the isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate.	fructose-6-phosphate	144-166	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
12122025-1	2002	Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation.	fructose-6-phosphate	45-57	mannose phosphate isomerase	Homo sapiens	0-24
12122025-1	2002	Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation.	fructose-6-phosphate	45-57	mannose phosphate isomerase	Homo sapiens	26-29
12122025-1	2002	Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation.	fructose-6-phosphate	59-66	mannose phosphate isomerase	Homo sapiens	0-24
11983887-1	2002	Phosphoglucose isomerase (EC ) catalyzes the second step in glycolysis, the reversible isomerization of D-glucose 6-phosphate to D-fructose 6-phosphate.	fructose-6-phosphate	129-151	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12122025-1	2002	Phosphomannose isomerase (PMI) interconverts fructose-6-P (Fru-6-P) and mannose-6-P (Man-6-P), linking energy metabolism to protein glycosylation.	fructose-6-phosphate	59-66	mannose phosphate isomerase	Homo sapiens	26-29
12023200-1	2002	Phosphomannose isomerase (PMI), an enzyme not present in many plants, catalyzes the reversible interconversion of mannose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	138-158	mannose phosphate isomerase	Homo sapiens	0-24
12023200-1	2002	Phosphomannose isomerase (PMI), an enzyme not present in many plants, catalyzes the reversible interconversion of mannose 6-phosphate and fructose 6-phosphate.	fructose-6-phosphate	138-158	mannose phosphate isomerase	Homo sapiens	26-29
12018941-1	2002	Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the first step in the biosynthesis of amino sugars by transferring the amino group from l-glutamine to the acceptor substrate, fructose 6-phosphate, generating the products glucosamine 6-phosphate and glutamic acid.	fructose-6-phosphate	192-212	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	0-47
12018941-1	2002	Glutamine:fructose-6-phosphate amidotransferase (GFAT) catalyzes the first step in the biosynthesis of amino sugars by transferring the amino group from l-glutamine to the acceptor substrate, fructose 6-phosphate, generating the products glucosamine 6-phosphate and glutamic acid.	fructose-6-phosphate	192-212	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	49-53
32689502-5	2002	Glucose-6-phosphate (G6P) was found to be an activator of apple SPS, and the activation was dependent upon the F6P concentration.	fructose-6-phosphate	111-114	probable sucrose-phosphate synthase 1	Malus domestica	64-67
11842094-5	2002	In a second assay method that measures the stimulation of glutaminase activity, a K(d) of 2 microm was measured for Fru-6-P binding to hGFAT1.	fructose-6-phosphate	116-123	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	135-141
11842094-11	2002	These data suggest that hGFAT1 is fully active at physiological levels of Fru-6-P and may be regulated by its product GlcN-6-P in addition to the pathway end product, UDP-GlcNAc.	fructose-6-phosphate	74-81	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	24-30
11895440-7	2002	Finally, the stimulation of chitin production was also accompanied by an increase in pools of fructose 6-Phosphate, a substrate of Gfa1p.	fructose-6-phosphate	94-114	glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1	Saccharomyces cerevisiae S288C	131-136
11842094-2	2002	A member of the N-terminal nucleophile class of amidotransferases, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate.	fructose-6-phosphate	128-150	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	67-71
11842094-3	2002	The kinetic constants reported previously for mammalian GFAT implicate a relatively low affinity for the acceptor substrate, fructose 6-phosphate (Fru-6-P, K(m) 0.2-1 mm).	fructose-6-phosphate	125-145	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	56-60
11842094-3	2002	The kinetic constants reported previously for mammalian GFAT implicate a relatively low affinity for the acceptor substrate, fructose 6-phosphate (Fru-6-P, K(m) 0.2-1 mm).	fructose-6-phosphate	147-154	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	56-60
11756407-0	2002	Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase.	fructose-6-phosphate	18-38	glucokinase	Rattus norvegicus	111-122
11756407-1	2002	Glucokinase is inhibited in the liver by a regulatory protein (GKRP) whose effects are increased by Fru-6-P and suppressed by Fru-1-P.	fructose-6-phosphate	100-107	glucokinase	Rattus norvegicus	0-11
11756407-1	2002	Glucokinase is inhibited in the liver by a regulatory protein (GKRP) whose effects are increased by Fru-6-P and suppressed by Fru-1-P.	fructose-6-phosphate	100-107	glucokinase regulator L homeolog	Xenopus laevis	63-67
11756407-3	2002	Mutations of three residues predicted to bind to Fru-6-P resulted in proteins that were approximately 5-fold (S110A) and 50-fold (S179A and K514A) less potent as inhibitors of glucokinase and had an at least 100-fold reduced affinity for the effectors.	fructose-6-phosphate	49-56	glucokinase	Rattus norvegicus	176-187
11756407-5	2002	The replacement of Gly(107), a residue close to the binding site, by cysteine (as in GlmS and Xenopus GKRP) resulted in a protein that had 20 times more affinity for Fru-6-P and 30 times less affinity for Fru-1-P.	fructose-6-phosphate	166-173	glucokinase regulator L homeolog	Xenopus laevis	102-106
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	fructose-6-phosphate	108-130	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
11796742-6	2002	Glutathione S-transferase protein fused either to rat liver or human pancreatic islet glucokinase were able to precipitate glucokinase regulatory protein from liver or hypothalamic extracts in the presence of fructose-6-phosphate, the amount of protein co-precipitated being decreased with fructose-1-phosphate.	fructose-6-phosphate	209-229	glucokinase regulator	Rattus norvegicus	123-153
11679416-11	2001	The apparent K(m) of GFAT1Alt for fructose-6-phosphate was approximately twofold higher than that of GFAT1, whereas K(i) for UDP-N-acetylglucosamine was approximately fivefold lower.	fructose-6-phosphate	34-54	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	21-26
11574420-1	2001	Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which fructose-6-phosphate is converted to glucosamine 6-phosphate by the rate-liming enzyme glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	170-190	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	257-304
11574420-1	2001	Recent studies have demonstrated that some of the effects of high glucose (HG) on cellular metabolism are mediated by the hexosamine biosynthesis pathway (HBP), in which fructose-6-phosphate is converted to glucosamine 6-phosphate by the rate-liming enzyme glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	170-190	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	306-309
11425306-0	2001	Crystal structure of rabbit phosphoglucose isomerase complexed with its substrate D-fructose 6-phosphate.	fructose-6-phosphate	82-104	glucose-6-phosphate isomerase	Oryctolagus cuniculus	28-52
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	fructose-6-phosphate	108-130	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	fructose-6-phosphate	132-135	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	fructose-6-phosphate	132-135	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
11425306-8	2001	In this paper, we report the X-ray crystal structure of rabbit PGI complexed with the cyclic form of its substrate, D-fructose 6-phosphate, at 2.1 A resolution.	fructose-6-phosphate	116-138	glucose-6-phosphate isomerase	Oryctolagus cuniculus	63-66
11023824-1	2000	Fructose-1,6-bisphosphatase (FBPase; EC 3.1.3.11), an important gluconeogenic enzyme, catalyses the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and P(i).	fructose-6-phosphate	144-164	fructose-bisphosphatase 2	Rattus norvegicus	29-35
11084042-1	2001	Phosphomannose isomerase (PMI) catalyzes the reversible interconversion of fructose 6-phosphate and mannose 6-phosphate, which is the first step in the biosynthesis of activated mannose donors required for the biosynthesis of various glycoconjugates.	fructose-6-phosphate	75-95	mannose phosphate isomerase	Mus musculus	26-29
11274905-3	2001	Glutamine: fructose-6-phosphate amidotransferase (GFA), the first and rate-limiting enzyme in this pathway, catalyzes the transfer of an amino group from glutamine to fructose-6-phosphate to form glucosamine-6-phosphate.	fructose-6-phosphate	11-31	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	50-53
11076949-1	2001	Using overexpressed Escherichia coli sorbitol-6-phosphate dehydrogenase to monitor fructose 6-phosphate formation, we found that the stimulation of fructose phosphorylation by glucose was reduced in two human beta-cell glucokinase mutants with a low Hill coefficient or when the activity of wild type glucokinase was decreased by replacing ATP with poorer nucleotide substrates.	fructose-6-phosphate	83-103	glucokinase	Homo sapiens	219-230
11085976-1	2001	A glucokinase regulatory protein has been reported to exist in the liver, which suppresses enzyme activity in a complex with fructose 6-phosphate, whereas no corresponding protein has been found in pancreatic beta cells.	fructose-6-phosphate	125-145	glucokinase	Rattus norvegicus	2-13
10898949-1	2000	The enzyme glutamine:fructose 6-phosphate amidotransferase (L-glutamine:D-fructose-6-phosphate amidotransferase; EC 2.6.1.16, GFAT) catalyzes the formation of glucosamine 6-phosphate from fructose 6-phosphate and glutamine.	fructose-6-phosphate	21-41	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	126-130
10770936-1	2000	Phosphoglucose isomerase catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate.	fructose-6-phosphate	90-110	glucose-6-phosphate isomerase 1	Mus musculus	0-24
10997914-2	2000	The HBP converts fructose-6-phosphate to glucosamine-6-phosphate via the rate-limiting enzyme, glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	17-37	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	95-142
10997914-2	2000	The HBP converts fructose-6-phosphate to glucosamine-6-phosphate via the rate-limiting enzyme, glutamine:fructose-6-phosphate amidotransferase (GFA).	fructose-6-phosphate	17-37	glutamine fructose-6-phosphate transaminase 1	Rattus norvegicus	144-147
11545174-3	2000	In the present study, by comparing the metabolism of glucose and fructose by both whole boar sperm and hypotonically treated cells, it is confirmed that fructose is phosphorylated by hexokinase to produce fructose 6-phosphate.	fructose-6-phosphate	205-225	hexokinase 1	Homo sapiens	183-193
10727432-5	2000	WISK phosphorylated recombinant heart PFK-2 in a time-dependent manner to the extent of 0.4 mol of phosphate incorporated/mol of enzyme subunit, and increased the V(max) of PFK-2 twofold, without affecting the K(m) for fructose 6-phosphate.	fructose-6-phosphate	219-239	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	38-43
10762070-1	2000	6-Phosphofructo-1-kinase and fructose-1,6-bisphosphatase are rate-limiting enzymes for glycolysis and gluconeogenesis respectively, in the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in the liver.	fructose-6-phosphate	139-159	phosphofructokinase, muscle	Homo sapiens	0-24
10762070-3	2000	Ribose 1,5-bisphosphate synergistically relieved the ATP inhibition and increased the affinity of liver 6-phosphofructo-1-kinase for fructose 6-phosphate in the presence of AMP.	fructose-6-phosphate	133-153	phosphofructokinase, muscle	Homo sapiens	104-128
10762070-5	2000	The activating effect on 6-phosphofructo-1-kinase and the inhibitory effect on fructose-1,6-bisphosphatase suggest ribose 1,5-bisphosphate is a potent regulator of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in the liver.	fructose-6-phosphate	168-188	phosphofructokinase, muscle	Homo sapiens	25-49
10916680-4	2000	GPI is a dimeric enzyme that catalyses the reversible interconversion of fructose-6-phosphate and glucose-6-phosphate.	fructose-6-phosphate	73-93	glucose-6-phosphate isomerase	Homo sapiens	0-3
10620331-5	2000	In the presence of 0.2 mM d-fructose 6-phosphate, the glucokinase regulatory protein caused a concentration-related inhibition of d-glucose phosphorylation, such an effect fading out at high concentrations of either d-glucose or glucokinase relative to that of its regulatory protein.	fructose-6-phosphate	26-48	glucokinase	Homo sapiens	54-65
10620331-5	2000	In the presence of 0.2 mM d-fructose 6-phosphate, the glucokinase regulatory protein caused a concentration-related inhibition of d-glucose phosphorylation, such an effect fading out at high concentrations of either d-glucose or glucokinase relative to that of its regulatory protein.	fructose-6-phosphate	26-48	glucokinase	Homo sapiens	229-240
10620331-6	2000	The phosphorylation of alpha-d-glucose by liver glucokinase appeared more resistant than that of beta-d-glucose to the inhibitory action of d-fructose 6-phosphate, as mediated by the glucokinase regulatory protein.	fructose-6-phosphate	140-162	glucokinase	Homo sapiens	48-59
10620331-6	2000	The phosphorylation of alpha-d-glucose by liver glucokinase appeared more resistant than that of beta-d-glucose to the inhibitory action of d-fructose 6-phosphate, as mediated by the glucokinase regulatory protein.	fructose-6-phosphate	140-162	glucokinase	Homo sapiens	183-194
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucokinase	Homo sapiens	15-26
10481068-5	1999	GFA1 was reported to encode L-glutamine:D-fructose-6-phosphate amidotransferase (GFAT) which catalyzes the synthesis of glucosamine-6-phosphate from glutamine and fructose-6-phosphate.	fructose-6-phosphate	42-62	glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1	Saccharomyces cerevisiae S288C	0-4
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucokinase	Homo sapiens	28-30
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	36-57
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	fructose-6-phosphate	124-144	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	59-69
9688258-0	1998	Mutagenesis of the fructose-6-phosphate-binding site in the 2-kinase domain of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.	fructose-6-phosphate	19-39	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	79-131
10206659-7	1999	Injection of buffer (0/6 oocytes) or fructose-6-phosphate, a product of GPI enzymatic reaction (0/5 oocytes), also failed to initiate Ca2+ responses.	fructose-6-phosphate	37-57	glucose-6-phosphate isomerase	Homo sapiens	72-75
9890979-2	1999	A bifunctional enzyme, fructose-6-phosphate,2-kinase/fructose 2, 6-bisphosphatase (Fru-6-P,2-kinase/Fru-2,6-Pase), catalyzes synthesis and degradation of fructose 2,6-bisphosphate (Fru-2,6-P2).	fructose-6-phosphate	83-90	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	23-81
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	fructose-6-phosphate	116-119	glutathione S-transferase kappa 1	Homo sapiens	4-7
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	fructose-6-phosphate	116-119	glucose-6-phosphate isomerase	Homo sapiens	8-11
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	fructose-6-phosphate	94-114	glutathione S-transferase kappa 1	Homo sapiens	4-7
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	fructose-6-phosphate	94-114	glucose-6-phosphate isomerase	Homo sapiens	8-11
9438414-1	1998	Glucosamine-6-phosphate deaminase (GNPDA) catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate.	fructose-6-phosphate	97-117	glucosamine-6-phosphate deaminase 1	Homo sapiens	0-33
9438414-1	1998	Glucosamine-6-phosphate deaminase (GNPDA) catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate.	fructose-6-phosphate	97-117	glucosamine-6-phosphate deaminase 1	Homo sapiens	35-40
9438414-1	1998	Glucosamine-6-phosphate deaminase (GNPDA) catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate.	fructose-6-phosphate	195-215	glucosamine-6-phosphate deaminase 1	Homo sapiens	0-33
9438414-1	1998	Glucosamine-6-phosphate deaminase (GNPDA) catalyzes the conversion of glucosamine-6-phosphate to fructose-6-phosphate, a reaction that under physiological conditions proceeds to the formation of fructose-6-phosphate.	fructose-6-phosphate	195-215	glucosamine-6-phosphate deaminase 1	Homo sapiens	35-40
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	170-190	glucokinase regulator	Homo sapiens	0-30
9540854-8	1997	Rapid inactivation occurred when GAP-DH was incubated with fructose 6-phosphate or prednisolone-21-hemisuccinate.	fructose-6-phosphate	59-79	LOC786101	Bos taurus	33-39
21528315-6	1997	PFK-1 cannot function in the absence of F-2,6-P-2 when only a suboptimal concentration of one of its substrates, fructose-6-phosphate (F-6-P), is present.	fructose-6-phosphate	113-133	phosphofructokinase, liver, B-type	Mus musculus	0-5
21528315-6	1997	PFK-1 cannot function in the absence of F-2,6-P-2 when only a suboptimal concentration of one of its substrates, fructose-6-phosphate (F-6-P), is present.	fructose-6-phosphate	135-140	phosphofructokinase, liver, B-type	Mus musculus	0-5
21528315-7	1997	When assayed under limiting F-6-P concentrations, it was found that following DMSO- or HMBA-induced differentiation, PFK-1 activity was decreased 7-20-fold.	fructose-6-phosphate	28-33	phosphofructokinase, liver, B-type	Mus musculus	117-122
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	192-195	glucokinase regulator	Homo sapiens	0-30
9230355-4	1997	Glucokinase regulatory protein gelled F-actin, and gelation was specifically inhibited by glucokinase and the regulatory protein effectors fructose-1-phosphate (F1P) and fructose-6-phosphate (F6P).	fructose-6-phosphate	192-195	glucokinase	Homo sapiens	90-101
8674049-4	1996	PHI catalyzes isomerization of glucose 6-phosphate to fructose 6-phosphate and is specific for both sugars.	fructose-6-phosphate	54-74	glucose-6-phosphate isomerase 1	Mus musculus	0-3
8922350-5	1996	In the presence of fructose-6-phosphate, the protein inhibits glucokinase in an allosteric competitive manner, while fructose-1-phosphate reverses this inhibition.	fructose-6-phosphate	19-39	glucokinase	Rattus norvegicus	62-73
7589825-8	1995	Kinetic studies of PFK activity in INS-1 cell extracts showed strong activation by micromolar concentrations of F16BP at near-physiological concentrations of ATP (several millimolar) and AMP and fructose 6-phosphate (micromolar), indicative of the M-type isoform.	fructose-6-phosphate	195-215	insulin 1	Rattus norvegicus	35-40
8639816-4	1996	Neuroleukin mediates differentiation of neurons and is homologous to PGI, which catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	137-157	glucose-6-phosphate isomerase	Homo sapiens	0-11
8639816-4	1996	Neuroleukin mediates differentiation of neurons and is homologous to PGI, which catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	137-157	glucose-6-phosphate isomerase	Homo sapiens	69-72
8763353-9	1996	We include one of these, the feedback inhibition of hexokinase by fructose-6-phosphate, in a first refinement of the model because there is experimental support for it in the literature.	fructose-6-phosphate	66-86	hexokinase 1	Homo sapiens	52-62
7755569-10	1995	This is in agreement with the known effect of fructose 6-phosphate to potentiate the inhibition of glucokinase by its regulatory protein.	fructose-6-phosphate	46-66	glucokinase	Rattus norvegicus	99-110
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	98-118	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	25-30
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	98-118	fructose-bisphosphatase 2	Rattus norvegicus	31-39
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	98-118	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	88-93
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	98-118	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	88-93
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	120-127	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	25-30
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	120-127	fructose-bisphosphatase 2	Rattus norvegicus	31-39
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	120-127	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	88-93
7619077-2	1995	In recombinant rat liver PFK-2/FBPase-2, mutation of Arg-225 to Ser increased the Km of PFK-2 for fructose-6-phosphate (Fru-6-P) 7-fold at pH 6 and decreased PFK-2 activity at suboptimal substrate concentrations between pH 6 and 9.5.	fructose-6-phosphate	120-127	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	88-93
7619077-9	1995	In recombinant rat muscle PFK-2/FBPase-2, mutation of Arg-104 to Ser increased the Km for Fru-6-P 60-fold, increased the IC50 of citrate, increased the Vmax.	fructose-6-phosphate	90-97	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	26-31
7619077-9	1995	In recombinant rat muscle PFK-2/FBPase-2, mutation of Arg-104 to Ser increased the Km for Fru-6-P 60-fold, increased the IC50 of citrate, increased the Vmax.	fructose-6-phosphate	90-97	fructose-bisphosphatase 2	Rattus norvegicus	32-40
7619077-13	1995	of FBPase-2 3-fold, increased the Km for Fru-2,6-P2 70-fold and increased the IC50 of Fru-6-P at least 300-fold.	fructose-6-phosphate	86-93	fructose-bisphosphatase 2	Rattus norvegicus	3-11
7619077-15	1995	The findings indicate that Arg-104 is involved in Fru-6-P binding in the PFK-2 domain and that it might also bind citrate.	fructose-6-phosphate	50-57	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Rattus norvegicus	73-78
7733279-6	1995	The hypothesis that fructose 6-phosphate and a protein regulator modulate glucokinase activity was evaluated by simulation analysis, as was the possibility that glucose-6-phosphatase, working in concert with phosphofructokinase, can modulate the glucose-sensing system.	fructose-6-phosphate	20-40	glucokinase	Homo sapiens	74-85
7733279-6	1995	The hypothesis that fructose 6-phosphate and a protein regulator modulate glucokinase activity was evaluated by simulation analysis, as was the possibility that glucose-6-phosphatase, working in concert with phosphofructokinase, can modulate the glucose-sensing system.	fructose-6-phosphate	20-40	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	161-182
7957955-3	1994	Like the latter, it inhibited rat liver glucokinase competitively with respect to glucose and its effect was sensitive to fructose 6-phosphate and fructose 1-phosphate.	fructose-6-phosphate	122-142	glucokinase	Rattus norvegicus	40-51
1322131-6	1992	Moreover, the thermostability of PFK-2 and the affinity of this enzyme for its substrate fructose 6-phosphate were increased upon transformation by Rous sarcoma virus.	fructose-6-phosphate	89-109	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	33-38
7804158-8	1994	It appears that the sensor triggering the ATPase-activating pathway is a complex responding both to a glucose-type sugar (Glc, Man, Fru) and possibly identical with one of the glucose carriers, and to one of its metabolites, most probably fructose-6-phosphate.	fructose-6-phosphate	239-259	zinc finger and BTB domain containing 22	Homo sapiens	132-135
8280078-16	1993	Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase.	fructose-6-phosphate	65-85	glucokinase	Homo sapiens	122-133
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase	Homo sapiens	14-38
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	234-254	glucose-6-phosphate isomerase	Homo sapiens	40-43
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	256-259	glucose-6-phosphate isomerase	Homo sapiens	14-38
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	fructose-6-phosphate	256-259	glucose-6-phosphate isomerase	Homo sapiens	40-43
8106374-10	1994	Fructose 2,6-bisphosphate, a potent activator of PFK, decreased the Km of PFK-C for fructose 6-phosphate from 200 to 60 microM while decreasing that of PFK-L from 300 to 55 microM.	fructose-6-phosphate	84-104	phosphofructokinase, platelet	Rattus norvegicus	74-79
8139758-8	1994	Mannose-6-phosphate was converted to fructose-6-phosphate by mannose-6-phosphate isomerase.	fructose-6-phosphate	37-57	mannose phosphate isomerase	Rattus norvegicus	61-90
8357848-6	1993	Our evidence from experiments with [1-13C]-, [2-13C]-, and [3-13C]D-glucoses indicates that there is an observable reverse flux of fructose 6-phosphate through the reactions catalyzed by transketolase and transaldolase, even in the presence of a net flux through the pentose phosphate pathway.	fructose-6-phosphate	131-151	transketolase	Homo sapiens	187-200
8357848-6	1993	Our evidence from experiments with [1-13C]-, [2-13C]-, and [3-13C]D-glucoses indicates that there is an observable reverse flux of fructose 6-phosphate through the reactions catalyzed by transketolase and transaldolase, even in the presence of a net flux through the pentose phosphate pathway.	fructose-6-phosphate	131-151	transaldolase 1	Homo sapiens	205-218
8142598-6	1993	This led to the identification of a futile substrate cycle between fructose 6-phosphate and fructose 1,6-bisphosphate as a novel energy sink that is activated by cachectin/TNF.	fructose-6-phosphate	67-87	tumor necrosis factor	Homo sapiens	162-171
8142598-6	1993	This led to the identification of a futile substrate cycle between fructose 6-phosphate and fructose 1,6-bisphosphate as a novel energy sink that is activated by cachectin/TNF.	fructose-6-phosphate	67-87	tumor necrosis factor	Homo sapiens	172-175
8394741-4	1993	Freezing also stimulated changes in the properties of liver PFK-2 including a decrease in maximal velocity, a basic shift in pH optimum, a 10-fold increase in Km for fructose-6-phosphate, and increased I50 values for enzyme inhibitors.	fructose-6-phosphate	166-186	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	60-65
1311308-2	1992	To identify those residues involved in fructose 6-phosphate binding to the kinase domain of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase site-directed mutations were engineered at Lys194, Arg195, Arg230, and Arg238.	fructose-6-phosphate	39-59	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	102-154
1599419-2	1992	In human erythrocytes, the first step in the metabolism of fructose is generally thought to be phosphorylation to fructose 6-phosphate catalysed by hexokinase.	fructose-6-phosphate	114-134	hexokinase 1	Homo sapiens	148-158
1535194-1	1992	Phosphofructokinases from granulocytes isolated from insulin-resistant patients, mainly those from type II diabetics where the degree of insulin resistance was more pronounced, exhibit some changes in their kinetic behavior when assayed under allosteric conditions, characterized by an increased affinity for fructose-6-phosphate, being more resistant to ATP inhibition while it became more sensitive to citrate inhibitory effect.	fructose-6-phosphate	309-329	insulin	Homo sapiens	53-60
1535194-1	1992	Phosphofructokinases from granulocytes isolated from insulin-resistant patients, mainly those from type II diabetics where the degree of insulin resistance was more pronounced, exhibit some changes in their kinetic behavior when assayed under allosteric conditions, characterized by an increased affinity for fructose-6-phosphate, being more resistant to ATP inhibition while it became more sensitive to citrate inhibitory effect.	fructose-6-phosphate	309-329	insulin	Homo sapiens	137-144
1496915-3	1992	In the presence of fructose 6-phosphate, the regulatory protein binds to, and inhibits, liver glucokinase.	fructose-6-phosphate	19-39	glucokinase	Rattus norvegicus	94-105
2002019-13	1991	Overall, these studies indicate that a unique metabolic pathway exists in adipocytes that mediates desensitization of the insulin-responsive GTS, and reveal that an early step in this pathway involves the conversion of fructose 6-phosphate to glucosamine 6-phosphate by the first and rate-limiting enzyme of the hexosamine pathway, glutamine:fructose-6-phosphate amidotransferase.	fructose-6-phosphate	219-239	insulin	Homo sapiens	122-129
1833982-8	1991	It is suggested that the high basal levels of F-2,6-P2 are, at least partly, a consequence of the high levels of fructose 6-phosphate, which will stimulate flux through PFK-2 and inhibit fructose-2,6-bisphosphatase.	fructose-6-phosphate	113-133	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	169-174
1889418-1	1991	In the absence of fructose 6-phosphate, the regulatory protein of rat liver glucokinase (hexokinase IV or D) inhibited this enzyme, though with a much (15-fold) lower potency than in the presence of a saturating concentration of fructose 6-phosphate.	fructose-6-phosphate	229-249	glucokinase	Rattus norvegicus	76-87
1889418-1	1991	In the absence of fructose 6-phosphate, the regulatory protein of rat liver glucokinase (hexokinase IV or D) inhibited this enzyme, though with a much (15-fold) lower potency than in the presence of a saturating concentration of fructose 6-phosphate.	fructose-6-phosphate	229-249	glucokinase	Rattus norvegicus	89-107
1889418-3	1991	In the presence of regulatory protein, sorbitol 6-phosphate, a potent analog of fructose 6-phosphate, exerted a hyperbolic, partial inhibition on glucokinase, the degree of which increased with the concentration of regulatory protein.	fructose-6-phosphate	80-100	glucokinase	Rattus norvegicus	146-157
1889418-9	1991	Sorbitol 6-phosphate, 2-deoxysorbitol 6-phosphate and mannitol 1-phosphate, all analogs of the open-chain configuration of fructose 6-phosphate, inhibited glucokinase in the presence of regulatory protein at lower concentrations than fructose 6-phosphate, whereas fixed analogs of the furanose form of fructose 6-phosphate were inactive or behaved as activators.	fructose-6-phosphate	123-143	glucokinase	Rattus norvegicus	155-166
1889418-9	1991	Sorbitol 6-phosphate, 2-deoxysorbitol 6-phosphate and mannitol 1-phosphate, all analogs of the open-chain configuration of fructose 6-phosphate, inhibited glucokinase in the presence of regulatory protein at lower concentrations than fructose 6-phosphate, whereas fixed analogs of the furanose form of fructose 6-phosphate were inactive or behaved as activators.	fructose-6-phosphate	234-254	glucokinase	Rattus norvegicus	155-166
1889418-9	1991	Sorbitol 6-phosphate, 2-deoxysorbitol 6-phosphate and mannitol 1-phosphate, all analogs of the open-chain configuration of fructose 6-phosphate, inhibited glucokinase in the presence of regulatory protein at lower concentrations than fructose 6-phosphate, whereas fixed analogs of the furanose form of fructose 6-phosphate were inactive or behaved as activators.	fructose-6-phosphate	234-254	glucokinase	Rattus norvegicus	155-166
2002019-13	1991	Overall, these studies indicate that a unique metabolic pathway exists in adipocytes that mediates desensitization of the insulin-responsive GTS, and reveal that an early step in this pathway involves the conversion of fructose 6-phosphate to glucosamine 6-phosphate by the first and rate-limiting enzyme of the hexosamine pathway, glutamine:fructose-6-phosphate amidotransferase.	fructose-6-phosphate	219-239	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	332-379
1900669-9	1991	E also appears to inhibit insulin-mediated glucose utilization, at least partly, because of an increase in G-6-phosphate (which inhibits hexokinase) and enhances glycolysis by G-1,6-P2-, fructose 6-phosphate-, and F-1,6-P2-mediated activation of PFK.	fructose-6-phosphate	187-207	insulin	Homo sapiens	26-33
2143630-8	1990	Glucose uptake by the islets, their insulin content, and both the Vmax and the apparent Km for fructose 6-phosphate of phosphofructokinase 1 (EC 2.7.1.11) in PTH-treated rats were not different from normal.	fructose-6-phosphate	95-115	phosphofructokinase, liver type	Rattus norvegicus	119-140
16667849-8	1990	Glucose-6-phosphate, fructose-6-phosphate, glucose-1-phosphate, and dihydroxyacetone phosphate activated PEPC at pH 7 in the absence of glycerol, but had no effect under the other assay conditions.	fructose-6-phosphate	21-41	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	105-109
1837585-3	1991	Phosphofructokinase-1 (PFK-1) is the enzyme that facilitates the conversion of fructose-6-phosphate to fructose-1,2-bisphosphate, a step in the glycolytic pathway that precedes the production of triose phosphates.	fructose-6-phosphate	79-99	phosphofructokinase, liver type	Rattus norvegicus	0-21
1837585-3	1991	Phosphofructokinase-1 (PFK-1) is the enzyme that facilitates the conversion of fructose-6-phosphate to fructose-1,2-bisphosphate, a step in the glycolytic pathway that precedes the production of triose phosphates.	fructose-6-phosphate	79-99	phosphofructokinase, liver type	Rattus norvegicus	23-28
1837585-5	1991	We studied the Vmax and Km of PFK-1 for fructose-6-phosphate in islets obtained from PD rats and pair-weighed (PW) animals fed the PD and normal diets, respectively, for 6 weeks.	fructose-6-phosphate	40-60	phosphofructokinase, liver type	Rattus norvegicus	30-35
1837585-7	1991	The data demonstrate that in PD (a) the affinity of PFK-1 for its substrate fructose-6-phosphate is reduced; (b) the combination of normal Vmax and high Km points toward the presence of a negative allosteric effector, and (c) the change in the activity of PFK-1 contributes to the defect in glucose metabolism by the pancreatic islets.	fructose-6-phosphate	76-96	phosphofructokinase, liver type	Rattus norvegicus	52-57
2280254-11	1990	We postulated that low pHi slows glycolysis with its associated ATP formation by reducing glycogenolysis and particularly by reducing conversion of fructose-6-phosphate to fructose-1,6-diphosphate through inhibition of phosphofructokinase (PFK), an enzyme which is known to be highly pH sensitive.	fructose-6-phosphate	148-168	glucose-6-phosphate isomerase	Homo sapiens	23-26
2173563-3	1990	Unfractionated extracts of each tissue readily converted fructose 1,6-bisphosphate to fructose 6-phosphate in assays for both plastidic and cytosolic FBPase.	fructose-6-phosphate	86-106	fructose-1,6-bisphosphatase	Zea mays	150-156
2152004-1	1990	Phosphofructokinase (ATP: D-fructose 6-phosphate 1-transferase) catalyzes the phosphorylation of fructose 6-phosphate (Fru-6-P) by ATP to from fructose 1,-bisphosphate, and is considered to be the key enzyme in glycolytic pathway in liver and other tissues.	fructose-6-phosphate	28-48	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	0-19
2384095-11	1990	The apparent mass of glucokinase, as determined by centrifugation in isokinetic sucrose gradient, was 55 kDa, and this value was unaffected by the separate presence of fructose 6-phosphate or of the regulatory protein.	fructose-6-phosphate	168-188	glucokinase	Rattus norvegicus	21-32
2384095-13	1990	Conversely, the presence of glucokinase increased the apparent molecular mass of the regulator in the presence of fructose 6-phosphate.	fructose-6-phosphate	114-134	glucokinase	Rattus norvegicus	28-39
2384095-14	1990	From these results, it is concluded that the regulatory protein inhibits glucokinase by forming a complex with this enzyme in the presence of fructose 6-phosphate, and that fructose 1-phosphate antagonises this inhibition by preventing the formation of the complex.	fructose-6-phosphate	142-162	glucokinase	Rattus norvegicus	73-84
2197090-1	1990	In the post-microsomal supernatant of pancreatic islets, prepared from fasted or fed rats, D-fructose 1-phosphate increased the activity of glucokinase by 20-30% as measured in the presence of D-glucose 6-phosphate and D-fructose 6-phosphate.	fructose-6-phosphate	219-241	glucokinase	Rattus norvegicus	140-151
2197090-6	1990	These findings suggest that the activity of glucokinase in islet cells may be regulated by a protein mediating the antagonistic effects of D-fructose 6-phosphate and D-fructose 1-phosphate in a manner qualitatively similar to that operating in hepatocytes, but with lower efficiency.	fructose-6-phosphate	139-161	glucokinase	Rattus norvegicus	44-55
2140983-5	1990	This derivative has almost the same specific activity and affinities for the two substrates (fructose-6-phosphate and ATP) as intact phosphofructokinase; the saturation by fructose 6-phosphate is also very cooperative.	fructose-6-phosphate	172-192	ATPase	Escherichia coli	93-121
2152004-1	1990	Phosphofructokinase (ATP: D-fructose 6-phosphate 1-transferase) catalyzes the phosphorylation of fructose 6-phosphate (Fru-6-P) by ATP to from fructose 1,-bisphosphate, and is considered to be the key enzyme in glycolytic pathway in liver and other tissues.	fructose-6-phosphate	119-126	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	0-19
2152004-13	1990	For the recovery of PFK activity from ATP-dependent inhibition, not only Fru-6-P but also AMP and fructose 2,6-bisphosphate (Fru-2,6-P2) were necessary.	fructose-6-phosphate	73-80	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	20-23
2152004-15	1990	In rabbit dental pulp, PFK was regulated synergistically by Fru-6-P, ATP, AMP and Fru-2,6-P2, and the range of the actual PFK activity seemed to be 30 to 80% of the maximum activity.	fructose-6-phosphate	60-67	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	23-26
34976860-3	2021	Phosphoglucose isomerase (PGI) catalyzes the reversible conversion between glucose-6-phosphate and fructose-6-phosphate, thus acting as a key node for glycolysis, pentose phosphate pathway, and cell wall biosynthesis in fungi.	fructose-6-phosphate	99-119	glucose-6-phosphate isomerase	Homo sapiens	26-29
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	fructose-6-phosphate	99-119	phosphoglucose isomerase 1	Arabidopsis thaliana	0-24
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	fructose-6-phosphate	99-119	phosphoglucose isomerase 1	Arabidopsis thaliana	26-29
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	fructose-6-phosphate	121-124	phosphoglucose isomerase 1	Arabidopsis thaliana	0-24
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	fructose-6-phosphate	121-124	phosphoglucose isomerase 1	Arabidopsis thaliana	26-29
2122108-9	1990	The control of glycolysis and of gluconeogenesis occurs mostly at the level of the interconversion of fructose 6-phosphate and fructose 1,6-bisphosphate under the action of phosphofructokinase 1 and fructose 1,6-bisphosphatase.	fructose-6-phosphate	102-122	phosphofructokinase, muscle	Homo sapiens	173-226
15334252-5	2004	The presence of F-actin increases the affinity of phosphofructokinase for fructose 6-phosphate nevertheless, with no changes in maximum velocity (Vmax).	fructose-6-phosphate	74-94	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	50-69
35450439-7	2022	Metabolomics analysis indicated an increased generation of fructose 1,6-bisphosphate, an intermediate in the glycolytic pathway converted by PFK1 (phosphofructokinase 1) from fructose-6-phosphate, in cells exposed to 15% stretch.	fructose-6-phosphate	175-195	phosphofructokinase, liver, B-type	Mus musculus	141-145
35358527-7	2022	The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression.	fructose-6-phosphate	53-73	phosphoglucomutase 1	Homo sapiens	144-148
35358527-7	2022	The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression.	fructose-6-phosphate	53-73	phosphoglucomutase 2	Homo sapiens	149-153
35358527-7	2022	The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression.	fructose-6-phosphate	53-73	glucose-6-phosphate isomerase	Homo sapiens	158-161
35358527-7	2022	The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression.	fructose-6-phosphate	53-73	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	210-215
35358527-7	2022	The evident increases in the glucose 1-phosphate and fructose 6-phosphate levels in HepG2 cells were proposed to be induced by the promotion of PGM1/PGM2 and GPI gene expression and the suppression of UPG2 and GFPT1/GFPT2 gene expression.	fructose-6-phosphate	53-73	glutamine-fructose-6-phosphate transaminase 2	Homo sapiens	216-221
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	fructose-6-phosphate	122-142	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	fructose-6-phosphate	122-142	2,4-dienoyl-CoA reductase 1	Homo sapiens	281-286
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	fructose-6-phosphate	144-147	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	fructose-6-phosphate	144-147	2,4-dienoyl-CoA reductase 1	Homo sapiens	281-286
35450439-7	2022	Metabolomics analysis indicated an increased generation of fructose 1,6-bisphosphate, an intermediate in the glycolytic pathway converted by PFK1 (phosphofructokinase 1) from fructose-6-phosphate, in cells exposed to 15% stretch.	fructose-6-phosphate	175-195	phosphofructokinase, liver, B-type	Mus musculus	147-168
35057031-7	2022	On the other hand, 2DG lacks the ability to convert into fructose-6-phosphate, resulting in a hampering of the activity of both glucose-6-phosphate isomerase and hexokinase, and finally causing cell death.	fructose-6-phosphate	57-77	glucose-6-phosphate isomerase	Homo sapiens	128-157
35179010-2	2022	It is encoded by FBP1, and the enzyme catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose 6-phosphate.	fructose-6-phosphate	95-115	fructose-bisphosphatase 1	Homo sapiens	17-21
35419769-4	2022	A critical step in glycolysis is controlled by the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which converts fructose 6-phosphate (F6P) to fructose 2,6-bisphosphate (F2,6BP).	fructose-6-phosphate	137-157	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	58-111
35419769-4	2022	A critical step in glycolysis is controlled by the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which converts fructose 6-phosphate (F6P) to fructose 2,6-bisphosphate (F2,6BP).	fructose-6-phosphate	137-157	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	113-119
35419769-4	2022	A critical step in glycolysis is controlled by the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which converts fructose 6-phosphate (F6P) to fructose 2,6-bisphosphate (F2,6BP).	fructose-6-phosphate	159-162	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	58-111
35419769-4	2022	A critical step in glycolysis is controlled by the enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), which converts fructose 6-phosphate (F6P) to fructose 2,6-bisphosphate (F2,6BP).	fructose-6-phosphate	159-162	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	113-119
35057031-7	2022	On the other hand, 2DG lacks the ability to convert into fructose-6-phosphate, resulting in a hampering of the activity of both glucose-6-phosphate isomerase and hexokinase, and finally causing cell death.	fructose-6-phosphate	57-77	hexokinase 1	Homo sapiens	162-172
2826925-0	1987	The appearance of a critical input concentration of fructose 6-phosphate in the 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase cycle.	fructose-6-phosphate	52-72	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	80-132
2521786-3	1989	The binding of PFK to actin is inhibited by ATP and ADP but not by fructose 6-phosphate or fructose 2,6-bisphosphate.	fructose-6-phosphate	67-87	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	15-18
2521786-3	1989	The binding of PFK to actin is inhibited by ATP and ADP but not by fructose 6-phosphate or fructose 2,6-bisphosphate.	fructose-6-phosphate	67-87	actin	Oryctolagus cuniculus	22-27
2902845-4	1988	The increase in phosphofructokinase-1 activity could be linked to the 2-fold increase in fructose 2,6-bisphosphate concentration, since no change in maximal activity and in sensitivity of the enzyme toward fructose 6-phosphate was detected in vitro.	fructose-6-phosphate	206-226	phosphofructokinase, liver type	Rattus norvegicus	16-37
2725285-3	1989	The activation of glycogen phosphorylase caused the mobilization of glycogen and increased the cellular concentration of hexose 6-phosphates (glucose 6-phosphate plus fructose 6-phosphate) and that of fructose 2,6-bisphosphate.	fructose-6-phosphate	167-187	glycogen phosphorylase L	Rattus norvegicus	18-40
2917560-0	1989	A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate.	fructose-6-phosphate	100-120	glucokinase	Rattus norvegicus	36-47
2917560-2	1989	Anion-exchange chromatography of liver extracts separated glucokinase from a fructose-6-phosphate-sensitive and fructose-1-phosphate-sensitive inhibitor of that enzyme.	fructose-6-phosphate	77-97	glucokinase	Rattus norvegicus	58-69
2917560-5	1989	It inhibited glucokinase competitively with respect to glucose and its inhibitory effect was greatly reinforced by fructose 6-phosphate although not by glucose 6-phosphate.	fructose-6-phosphate	115-135	glucokinase	Rattus norvegicus	13-24
2529854-6	1989	Finally, PFK-2 was rechromatographed at CM-Sephadex and specifically eluted with fructose 6-phosphate.	fructose-6-phosphate	81-101	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	9-14
3352744-6	1988	We have cloned the gene for pig muscle phosphohexose isomerase (PHI) (EC 5.3.1.9) which catalyses the conversion of glucose-6-phosphate to fructose-6-phosphate, an obligatory step in glycolysis, and determined its amino-acid sequence.	fructose-6-phosphate	139-159	glucose-6-phosphate isomerase	Homo sapiens	39-62
3352744-6	1988	We have cloned the gene for pig muscle phosphohexose isomerase (PHI) (EC 5.3.1.9) which catalyses the conversion of glucose-6-phosphate to fructose-6-phosphate, an obligatory step in glycolysis, and determined its amino-acid sequence.	fructose-6-phosphate	139-159	glucose-6-phosphate isomerase	Sus scrofa	64-67
3440115-1	1987	Using ion-exchange chromatography of sucrose phosphates on Dowex-1, it was demonstrated that the highly purified rat liver transketolase (specific activity 1.7 mumol/min.mg protein) is capable of catalyzing the synthesis of erythrose-4-phosphate, a metabolite of the pentose phosphate pathway non-oxidizing step, from the initial participants of glycolysis, i. e., glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	389-409	transketolase	Rattus norvegicus	123-136
3440115-6	1987	The transketolase reaction provides for the relationship between glycolysis and the anaerobic step of the pentose phosphate pathway which share common metabolites, i. e. glucose-6-phosphate and fructose-6-phosphate.	fructose-6-phosphate	194-214	transketolase	Rattus norvegicus	4-17
4055792-14	1985	The Km for Fru-6-P was temperature dependent for the GPI-B2 isozyme, but relatively temperature independent for GPI-A2 between 10 and 35 degrees C. The Ki for 6-P-gluconate was temperature dependent for both isozymes.	fructose-6-phosphate	11-18	glucose-6-phosphate isomerase b	Fundulus heteroclitus	53-56
3034335-3	1987	The model takes into account inhibitory effect of F2, 6P2 and fructose-6-phosphate (F6P) on protein kinase, which phosphorylates the bifunctional enzyme fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase.	fructose-6-phosphate	62-82	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Homo sapiens	153-210
3034335-3	1987	The model takes into account inhibitory effect of F2, 6P2 and fructose-6-phosphate (F6P) on protein kinase, which phosphorylates the bifunctional enzyme fructose-6-phosphate-2-kinase/fructose-2,6-bisphosphatase.	fructose-6-phosphate	84-87	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Homo sapiens	153-210
3719111-8	1986	Only GPI Homburg showed an altered electrophoretic mobility and an increased affinity for fructose-6-phosphate.	fructose-6-phosphate	90-110	glucose-6-phosphate isomerase	Homo sapiens	5-8
2942107-3	1986	For both PFK homologs, carbethoxylation reduces the sensitivity to ATP and citrate inhibition, the cooperativity as a function of fructose 6-phosphate concentration and the degree of activation in the presence ADP, AMP, and fructose 2,6-bisphosphate.	fructose-6-phosphate	130-150	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	9-12
4031071-6	1985	The difference between the Ra determined by 3-D1-glucose (Ra3) and the Ra determined by 6,6-D2-glucose (Ra6) represents the SCR between fructose-6-phosphate and fructose-1,6-diphosphate.	fructose-6-phosphate	136-156	RA3	Homo sapiens	58-61
4031071-6	1985	The difference between the Ra determined by 3-D1-glucose (Ra3) and the Ra determined by 6,6-D2-glucose (Ra6) represents the SCR between fructose-6-phosphate and fructose-1,6-diphosphate.	fructose-6-phosphate	136-156	RA6	Homo sapiens	104-107
6325420-4	1984	Rat liver phosphofructokinase-1 phosphorylates 2,5-anhydromannitol-1-P; the rate is less than that for fructose-6-P but is stimulated by fructose-2,6-P2.	fructose-6-phosphate	103-115	phosphofructokinase, liver type	Rattus norvegicus	10-31
6240227-11	1984	However, factor A was a K-type activator with respect to fructose-6-P, increasing both the Km and Ki for ATP, and slightly increasing the Vm.	fructose-6-phosphate	57-69	glycogen synthase kinase 3 alpha	Rattus norvegicus	9-17
6091640-1	1984	The Fru-6-P/Fru-2,6-P2 exchange reaction of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase was almost entirely dependent on the presence of Pi.	fructose-6-phosphate	4-11	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	54-106
3160350-3	1985	Incubation of phosphofructokinase in the presence of protein kinase C, phospholipids, Ca2+, and ATP appears to affect the allosteric properties of phosphofructokinase by shifting the fructose 6-phosphate saturation curve to lower substrate concentrations in a time-dependent manner and decreasing cooperativity of the enzyme.	fructose-6-phosphate	183-203	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	14-33
3160350-3	1985	Incubation of phosphofructokinase in the presence of protein kinase C, phospholipids, Ca2+, and ATP appears to affect the allosteric properties of phosphofructokinase by shifting the fructose 6-phosphate saturation curve to lower substrate concentrations in a time-dependent manner and decreasing cooperativity of the enzyme.	fructose-6-phosphate	183-203	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	147-166
2999581-8	1985	Adsorption of human NKCF to U937 cells is inhibited by mannose-6-phosphate and adsorption of rodent NKCF to YAC-1 cells is inhibited by alpha-methyl-D-mannoside and fructose-6-phosphate.	fructose-6-phosphate	165-185	ADP-ribosyltransferase 1	Mus musculus	108-113
6092363-1	1984	Rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase catalyzes exchange reactions between ADP and ATP and between fructose-6-P and fructose-2,6-P2 at histidyl residues.	fructose-6-phosphate	124-136	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	10-62
6236976-14	1984	To a minor degree calmodulin also counteracts the stabilization of the tetrameric form caused by fructose 6-phosphate and hexose bisphosphate, now however antagonistically to AMP and ADP.	fructose-6-phosphate	97-117	calmodulin 1	Homo sapiens	18-28
6713626-2	1984	Heating the hemolysate (55 degrees C, 5 min) inactivates transaldolase (EC 2.2.1.2), the enzyme that catalyzes the formation of fructose 6-phosphate and erythrose 4-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate.	fructose-6-phosphate	128-148	transaldolase 1	Homo sapiens	57-70
6325420-5	1984	At 1 mM fructose-6-P, bisphosphate compounds activate rat liver phosphofructokinase-1 in the following order of effectiveness: fructose-2,6-P2 much greater than 2,5-anhydromannitol-1,6-P2 greater than fructose-1,6-P2 greater than 2,5-anhydroglucitol-1,6-P2.	fructose-6-phosphate	8-20	phosphofructokinase, liver type	Rattus norvegicus	64-85
6098271-0	1984	Inhibition of fructose-1,6-bisphosphatase from pig liver by fructose-6-phosphate.	fructose-6-phosphate	60-80	fructose-bisphosphatase 1	Sus scrofa	14-41
16663429-9	1984	The affinity of PFP for this activator was reduced by decreasing the concentration of fructose 6-phosphate or increasing that of phosphate.	fructose-6-phosphate	86-106	pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha	Ricinus communis	16-19
16663429-10	1984	Phosphate inhibited PFP when the reaction was measured in the reverse direction, i.e. fructose 6-phosphate production.	fructose-6-phosphate	86-106	pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha	Ricinus communis	20-23
16663429-12	1984	The possible roles of fructose 2,6-bisphosphate, fructose 6-phosphate, and phosphate in the control of PFP are discussed.	fructose-6-phosphate	49-69	pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha	Ricinus communis	103-106
6098271-1	1984	The inhibition of the neutral form of fructose-1,6-bisphosphatase from pig liver by fructose-6-phosphate was investigated in the substrate concentration range of 0.05-500 microM by determination of the rate of formation of labelled inorganic phosphate from [1-32P]fructose-1,6-bisphosphate.	fructose-6-phosphate	84-104	fructose-bisphosphatase 1	Sus scrofa	38-65
6870826-4	1983	The validity and accuracy of this method of progress-curve analysis was established by comparing the Km value of glucose 6-phosphate dehydrogenase for glucose 6-phosphate generated in situ by the action of glucose phosphate isomerase on fructose 6-phosphate with that determined from initial-rate measurements.	fructose-6-phosphate	237-257	glucose-6-phosphate dehydrogenase	Homo sapiens	113-146
6228252-3	1983	In the presence of saturating amounts of fructose 6-phosphate and the nonhydrolyzable ATP analogue 5"-adenylyl imidodiphosphate, the inactivated PFK sediments as a 13.5S component.	fructose-6-phosphate	41-61	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	145-148
6304027-1	1983	Rat liver 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase was phosphorylated by [gamma-32P]ATP plus fructose-6-P or [2-32P]fructose-2,6-P2.	fructose-6-phosphate	105-117	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	10-62
6288113-1	1982	Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase and sorbitol dehydrogenase by the reduction of glucose 6-phosphate and fructose 6-phosphate, respectively, has been demonstrated.	fructose-6-phosphate	147-167	aldo-keto reductase family 1 member B	Homo sapiens	59-75
6132318-6	1983	The availability of glutamine, and the activity of glutamine synthetase may control fructose-6-phosphate metabolism, and the increased ratio of fructose-1,6-diphosphatase to glutamine synthetase in Huntington"s disease may explain the accumulation of glycogen, and the reduction in ganglioside levels reported in this state.	fructose-6-phosphate	84-104	glutamate-ammonia ligase	Homo sapiens	51-71
6862092-11	1983	The coupled transketolase-transaldolase reactions, 2 fructose 6-phosphate in equilibrium altro-heptulose 7-phosphate + xylulose 5-phosphate and 2 altro-heptulose 7-phosphate in equilibrium fructose 6-phosphate + D-glycero D-altro octulose 8-phosphate were demonstrated with purified enzymes, but are concluded to play a minor role in the non-oxidative synthesis of pentose 5-phosphate and octulose phosphate by (RLEP).	fructose-6-phosphate	53-73	transketolase	Rattus norvegicus	12-25
6862092-11	1983	The coupled transketolase-transaldolase reactions, 2 fructose 6-phosphate in equilibrium altro-heptulose 7-phosphate + xylulose 5-phosphate and 2 altro-heptulose 7-phosphate in equilibrium fructose 6-phosphate + D-glycero D-altro octulose 8-phosphate were demonstrated with purified enzymes, but are concluded to play a minor role in the non-oxidative synthesis of pentose 5-phosphate and octulose phosphate by (RLEP).	fructose-6-phosphate	189-209	transketolase	Rattus norvegicus	12-25
6218165-13	1983	The properties of pfk1 mutants suggest that yeast has an alternative mechanism for the aerobic metabolism of fructose-6-P, presumably through the recently reported particulate P-fructokinase (Lobo, Z., and Maitra, P. K. (1982) FEBS Lett.	fructose-6-phosphate	109-121	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	18-22
6100582-5	1983	Synthesis of the compound is catalyzed by a unique enzyme which transfers the gamma-phosphate of ATP to the C2 position of fructose 6-phosphate (ATP:D fructose 6-phosphate 2-phosphotransferase) while degradation is catalyzed by a phosphohydrolase activity which is specific for the C-2 position of fructose 2,6-bisphosphate (D-fructose 2,6-bisphosphate 2-phosphohydrolase).	fructose-6-phosphate	123-143	complement C2	Rattus norvegicus	282-285
6100582-11	1983	However, in the presence of fructose 6-phosphate the enzyme did not transfer phosphate to water but rather to the C-2 position of the phosphorylated sugar.	fructose-6-phosphate	28-48	complement C2	Rattus norvegicus	114-117
6288113-1	1982	Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase and sorbitol dehydrogenase by the reduction of glucose 6-phosphate and fructose 6-phosphate, respectively, has been demonstrated.	fructose-6-phosphate	147-167	sorbitol dehydrogenase	Homo sapiens	80-102
6448081-1	1980	The uncontrollable substrate recirculation in the central futile cycle (FC) in the carbohydrate energy metabolism fructose-6-P (F6P) in equilibrium or formed from fructose-1,6-P2 (FBP), makes it impossible to maintain a stable level of ATP because of its wasteful expenditure in the cycle reactions which are equivalent to the ATPase reaction and also because of the diversion of FBP from glycolytic phosphorylation of ADP.	fructose-6-phosphate	114-126	ECB2	Homo sapiens	180-183
6272698-2	1980	The method proposed by Rognstad & Katz [(1976) Arch, Biochem, Biophys, 177, 337-345] for the determination of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle by the randomization of carbon between C-1 and C-6 of glucose glucose formed from [1-14C] galactose was applied to anaesthetized rats and conscious mice.	fructose-6-phosphate	118-138	complement C6	Rattus norvegicus	210-221
6272698-4	1980	It was checked that the hydrolysis of fructose 6-phosphate by glucose 6-phosphatase is too weak to invalidate the method.	fructose-6-phosphate	38-58	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	62-83
6954519-4	1982	The inability of glucosamine and mannose to promote a transport curb in the PGI strain must be ascribed to the fact that the 6-esters of these aldohexoses are converted by their own specific deaminase and isomerase to fructose 6-phosphate, which initiates the pyruvate-tricarboxylate energy-yielding pathway but cannot be converted to glucose 6-phosphate in the mutant.	fructose-6-phosphate	218-238	glucose-6-phosphate isomerase	Cricetulus griseus	76-79
6115414-1	1981	Glucose-6-phosphate isomerase (EC 5.3.1.9) is a dimeric enzyme of molecular mass 132000 which catalyses the interconversion of D-glucose-6-phosphate and D-fructose-6-phosphate.	fructose-6-phosphate	153-175	glucose-6-phosphate isomerase	Sus scrofa	0-29
6448081-1	1980	The uncontrollable substrate recirculation in the central futile cycle (FC) in the carbohydrate energy metabolism fructose-6-P (F6P) in equilibrium or formed from fructose-1,6-P2 (FBP), makes it impossible to maintain a stable level of ATP because of its wasteful expenditure in the cycle reactions which are equivalent to the ATPase reaction and also because of the diversion of FBP from glycolytic phosphorylation of ADP.	fructose-6-phosphate	114-126	ECB2	Homo sapiens	380-383
6243953-8	1980	Initial rate kinetics were used to study the reverse reaction of FBPase; AMP was a slope-parabolic, intercept-parabolic noncompetitive inhibitor with respect to both fructose 6-phosphate and inorganic phosphate.	fructose-6-phosphate	166-186	fructose-bisphosphatase 1	Bos taurus	65-71
6446931-2	1980	The addition of F-actin to solutions of phosphofructokinase at low ionic strength (10 mM KCl and 5 mM MgCl2) partially reverses the inhibition of the enzyme seen at high ATP concentrations and increases the apparent affinity of the enzyme for fructose 6-phosphate with slight effect on Vmax.	fructose-6-phosphate	243-263	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	40-59
6995116-1	1980	In the presence of hexacyanoferrate(III), or other suitable oxidants, transketolase catalyzes the oxidative cleavage of its donor substrates xylulose 5-phosphate or fructose 6-phosphate into glycolate and glyceraldehyde 3-phosphate or erythrose 4-phosphate, respectively.	fructose-6-phosphate	165-185	transketolase	Homo sapiens	70-83
6155905-2	1980	Both PGI variants were shown to be dimers of the same molecular weight, sedimentation coefficient, and Km for fructose-6-phosphate.	fructose-6-phosphate	110-130	glucose-6-phosphate isomerase 1	Mus musculus	5-8
631848-4	1978	GPI "Paris" was characterized by a slow electrophoretic migration and, above all, a drastically altered affinity for the substrates glucose-6-phosphate (decreased) and fructose-6-phosphate (increased).	fructose-6-phosphate	168-188	glucose-6-phosphate isomerase	Homo sapiens	0-3
41878-2	1979	The recycling of fructose-6-phosphate is mediated by two membrane-bound enzymes: phosphofructokinase (PFK) and fructose-1,6-diphosphatase (FDPase).	fructose-6-phosphate	17-37	ATP-dependent 6-phosphofructokinase	Apis mellifera	102-105
631848-5	1978	GPI "Enfants malades" exhibited a slightly reduced electrophoretic mobility, an abnormal curve of the activity in function of pH, and an abnormal ratio of maximal velocity in the backward direction (fructose-6-phosphate leads to glucose-6-phosphate) to that in the forward direction (glucose-6-phosphate leads to fructose-6-phosphate).	fructose-6-phosphate	199-219	glucose-6-phosphate isomerase	Homo sapiens	0-3
631848-5	1978	GPI "Enfants malades" exhibited a slightly reduced electrophoretic mobility, an abnormal curve of the activity in function of pH, and an abnormal ratio of maximal velocity in the backward direction (fructose-6-phosphate leads to glucose-6-phosphate) to that in the forward direction (glucose-6-phosphate leads to fructose-6-phosphate).	fructose-6-phosphate	313-333	glucose-6-phosphate isomerase	Homo sapiens	0-3
139173-2	1976	Citrate and fructose-6-phosphate elute PFK at concentrations of 1.0 and 2.5 mM respectively, i.e. without increasing the ionic strength of the starting buffer (similar to 0.12).	fructose-6-phosphate	12-32	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	39-42
911866-2	1977	Human erythrocyte hexokinase (ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1) was inhibited competitively with respect to MgATP2- by glucose-6-P (Ki - 10.8 muM) and fructose-6-P (Ki = 160 muM).	fructose-6-phosphate	165-177	hexokinase 1	Homo sapiens	18-28
911866-2	1977	Human erythrocyte hexokinase (ATP: D-hexose 6-phosphotransferase, EC 2.7.1.1) was inhibited competitively with respect to MgATP2- by glucose-6-P (Ki - 10.8 muM) and fructose-6-P (Ki = 160 muM).	fructose-6-phosphate	165-177	hexokinase 3	Homo sapiens	30-64
1259946-6	1976	Furthermore, milimolar levels of fructose 1,6-bisphosphate eluted the enzyme from ghosts, while fructose 6-phosphate and NADH (a metabolite which elutes human erythrocyte glyceraldehyde-3-phosphate dehydrogenase (G3PD) from its binding site) were ineffectuve.	fructose-6-phosphate	96-116	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	171-211
1259946-6	1976	Furthermore, milimolar levels of fructose 1,6-bisphosphate eluted the enzyme from ghosts, while fructose 6-phosphate and NADH (a metabolite which elutes human erythrocyte glyceraldehyde-3-phosphate dehydrogenase (G3PD) from its binding site) were ineffectuve.	fructose-6-phosphate	96-116	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	213-217
144126-5	1977	Unlike free phosphofructokinase, the membrane-bound phosphofructokinase is not inhibited by ATP or 2,3-diphosphoglycerate, and its fructose-6-P saturation curve is nonsigmoidal.	fructose-6-phosphate	131-143	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	52-71
10080-5	1976	For transaldolase, apparent Km values of 0.13 mM (normal liver) and 0.17 mM (hepatoma) were observed for erythrose 4-phosphate and of 0.30 to 0.35 mM for fructose 6-phosphate.	fructose-6-phosphate	154-174	transaldolase 1	Rattus norvegicus	4-17
776982-1	1976	The transaldolase-dihydroxyacetone carbanion intermediate formed in the reaction of transaldolase with its donor substrates fructose-6-P or sedoheptulose-7-P is susceptible to oxidation by hexacyanoferrate(III).	fructose-6-phosphate	124-136	transaldolase 1	Homo sapiens	4-17
776982-1	1976	The transaldolase-dihydroxyacetone carbanion intermediate formed in the reaction of transaldolase with its donor substrates fructose-6-P or sedoheptulose-7-P is susceptible to oxidation by hexacyanoferrate(III).	fructose-6-phosphate	124-136	transaldolase 1	Homo sapiens	84-97
776982-4	1976	In the presence of hexacyanoferrate(III) transaldolase thus functions as an efficient catalyst of the oxidative cleavage of its donor substrates fructose-6-P or sedoheptulose-7-P into hydroxypyruvaldehyde and glyceraldehyde-3-P or erythrose-4-P, respectively.	fructose-6-phosphate	145-157	transaldolase 1	Homo sapiens	41-54
171891-0	1975	On the influence of fructose-6-phosphate, ammonium, ATP and AMP on the conformation of the phosphofructokinase from rabbit muscle.	fructose-6-phosphate	20-40	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	91-110
123467-0	1975	An equilibrium binding study of the interaction of fructose 6-phosphate and fructose 1,6-bisphosphate with rabbit muscle phosphofructokinase.	fructose-6-phosphate	51-71	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	121-140
123467-1	1975	Equilibrium binding studies of the interaction of rabbit muscle phosphofructokinase with fructose 6-phosphate and fructose 1,6-bisphosphate have been carried out at 5 degrees in the presence of 1-10 mM potassium phosphate (pH 7.0 and 8.0), 5 mM citrate (pH 7.0), or 0.22 mm adenylyl imidodiphosphate (pH 7.0 and 8.0).	fructose-6-phosphate	89-109	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	64-83
123467-9	1975	The characteristic sigmoidal initial velocity-fructose 6-phosphate isotherms for phosphofructokinase at pH 7.0, therefore, are due to an heterotropic interaction between ATP and fructose 6-phosphate binding sites which alters the homotropic interactions between fructose 6-phosphate binding sites.	fructose-6-phosphate	46-66	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	81-100
123467-9	1975	The characteristic sigmoidal initial velocity-fructose 6-phosphate isotherms for phosphofructokinase at pH 7.0, therefore, are due to an heterotropic interaction between ATP and fructose 6-phosphate binding sites which alters the homotropic interactions between fructose 6-phosphate binding sites.	fructose-6-phosphate	178-198	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	81-100
123467-9	1975	The characteristic sigmoidal initial velocity-fructose 6-phosphate isotherms for phosphofructokinase at pH 7.0, therefore, are due to an heterotropic interaction between ATP and fructose 6-phosphate binding sites which alters the homotropic interactions between fructose 6-phosphate binding sites.	fructose-6-phosphate	178-198	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	81-100
16742603-5	1968	Transaldolase was measured with fructose 6-phosphate and erythrose 4-phosphate as substrates, and again glyceraldehyde 3-phosphate was measured by using the same coupled system.	fructose-6-phosphate	32-52	transaldolase 1	Homo sapiens	0-13
4634433-0	1972	A regulatory mechanism for CO 2  assimilation in plant photosynthesis: activation of ribulose-1,5-diphosphate carboxylase by fructose 6-phosphate and deactivation by fructose 1,6-diphosphate.	fructose-6-phosphate	125-145	complement C2	Homo sapiens	27-31
24499978-7	1970	On the other hand, the glycolytic pathway via fructose-6-phosphate becomes more effective in suberizing tissue, as is indicated by enhanced activity of phosphoglucoisomerase and accumulation of F-6-P.Little or no difference can be found with regard to hexokinase, triosephosphateisomerase, aldolase and pyruvate-kinase; on the other hand suberin formation strongly stimulates phosphoglyceromutase.	fructose-6-phosphate	46-66	hexokinase-1	Solanum tuberosum	252-262
24499978-7	1970	On the other hand, the glycolytic pathway via fructose-6-phosphate becomes more effective in suberizing tissue, as is indicated by enhanced activity of phosphoglucoisomerase and accumulation of F-6-P.Little or no difference can be found with regard to hexokinase, triosephosphateisomerase, aldolase and pyruvate-kinase; on the other hand suberin formation strongly stimulates phosphoglyceromutase.	fructose-6-phosphate	46-66	pyruvate kinase, cytosolic isozyme	Solanum tuberosum	303-318
32959326-3	2021	Transcriptional analysis revealed the increase of PGM2 transcription level leading to enhance glucose-6-phosphate and fructose-6-phosphate and plays a key role in ensuring a higher glycolytic flux in the PGM2 strain.	fructose-6-phosphate	118-138	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	50-54
13762870-0	1961	Formation of unequally labeled fructose 6-phosphate by an exchange reaction catalyzed by transaldolase.	fructose-6-phosphate	31-51	transaldolase 1	Homo sapiens	89-102
13125597-0	1954	Transketolase-catalyzed utilization of fructose 6-phosphate and its significance in a glucose 6-phosphate oxidation cycle.	fructose-6-phosphate	39-59	transketolase	Homo sapiens	0-13
32937226-5	2021	GFAT catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine.	fructose-6-phosphate	61-81	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	0-4
32915402-3	2020	One of the critical determinants of glycolytic flux is the enzyme, phosphofructokinase (PFK) which converts fructose-6-phosphate into fructose 1,6, bisphosphate.	fructose-6-phosphate	108-128	phosphofructokinase, platelet	Homo sapiens	88-91
33141153-4	2020	Under the conditions tested PFK-M has the highest affinities for F6P and ATP (K0.5ATP 152muM; K0.5F6P 147muM), PFK-P the lowest affinities (K0.5ATP 276muM; K0.5F6P 1333muM), and PFK-L demonstrates a high ATP affinity and low F6P affinity (K0.5ATP 160muM; K0.5F6P 1360muM).	fructose-6-phosphate	65-68	phosphofructokinase, muscle	Homo sapiens	28-33
33141153-4	2020	Under the conditions tested PFK-M has the highest affinities for F6P and ATP (K0.5ATP 152muM; K0.5F6P 147muM), PFK-P the lowest affinities (K0.5ATP 276muM; K0.5F6P 1333muM), and PFK-L demonstrates a high ATP affinity and low F6P affinity (K0.5ATP 160muM; K0.5F6P 1360muM).	fructose-6-phosphate	98-101	phosphofructokinase, muscle	Homo sapiens	28-33
33303629-6	2021	In addition, hGFAT2 is able to isomerize fructose-6-phosphate into glucose-6-phosphate even in the presence of equimolar amounts of glutamine, which results in unproductive glutamine hydrolysis.	fructose-6-phosphate	41-61	glutamine-fructose-6-phosphate transaminase 2	Homo sapiens	13-19
33278716-5	2020	GFAT catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine.	fructose-6-phosphate	61-81	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	0-4
32682158-1	2020	Phosphoglucose isomerase (PGI) is a cytosolic enzyme that catalyzes the reversible interconversion of d-glucose 6-phosphate and d-fructose 6-phosphate in glycolysis.	fructose-6-phosphate	128-150	glucose-6-phosphate isomerase	Homo sapiens	0-24
32682158-1	2020	Phosphoglucose isomerase (PGI) is a cytosolic enzyme that catalyzes the reversible interconversion of d-glucose 6-phosphate and d-fructose 6-phosphate in glycolysis.	fructose-6-phosphate	128-150	glucose-6-phosphate isomerase	Homo sapiens	26-29
31613799-5	2020	The rate-limiting enzyme of the pathway, glutamine-fructose amidotransferase (GFAT1), uses glutamine and fructose 6-phosphate to eventually synthesize UDP-GlcNAc.	fructose-6-phosphate	105-125	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	78-83
32019926-1	2020	Glutamine fructose-6-phosphate amidotransferase (GFAT) is the key enzyme in the hexosamine pathway (HP) that produces uridine 5"-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), linking energy metabolism with posttranslational protein glycosylation.	fructose-6-phosphate	0-30	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	49-53
32891058-4	2020	Insulin stimulated glycolysis by promoting Glut4 activity by enhancing phosphorylation of AS160 at S595, stimulated fatty acid synthesis by promoting Acly activity through allosteric activation by glucose 6-phosphate or fructose 6-phosphate, and stimulated glutamate synthesis by alleviating allosteric inhibition of Gls by glutamate.	fructose-6-phosphate	220-240	insulin	Homo sapiens	0-7
32891058-4	2020	Insulin stimulated glycolysis by promoting Glut4 activity by enhancing phosphorylation of AS160 at S595, stimulated fatty acid synthesis by promoting Acly activity through allosteric activation by glucose 6-phosphate or fructose 6-phosphate, and stimulated glutamate synthesis by alleviating allosteric inhibition of Gls by glutamate.	fructose-6-phosphate	220-240	TBC1 domain family member 4	Homo sapiens	90-95
32891058-4	2020	Insulin stimulated glycolysis by promoting Glut4 activity by enhancing phosphorylation of AS160 at S595, stimulated fatty acid synthesis by promoting Acly activity through allosteric activation by glucose 6-phosphate or fructose 6-phosphate, and stimulated glutamate synthesis by alleviating allosteric inhibition of Gls by glutamate.	fructose-6-phosphate	220-240	ATP citrate lyase	Homo sapiens	150-154
32487995-4	2020	We report a dramatic reduction in serum amyloid A1 protein in ICM hearts, perturbed thyroid hormone signalling pathways and significant reductions in oxidoreductase co-factor riboflavin-5-monophosphate and glycolytic intermediate fructose-6-phosphate in both; unveil gender-specific changes in HF, including nitric oxide-related arginine metabolism, mitochondrial substrates, and X chromosome-linked protein and metabolite changes; and provide an interactive online application as a publicly-available resource.	fructose-6-phosphate	230-250	serum amyloid A1	Homo sapiens	34-50
31874685-4	2020	In this study, a scaffoldin-mediated two-enzyme complex containing triosephosphate isomerase (TIM) and fructose-1,6-bisphosphate aldolase/phosphatase (FBPA) was constructed, and the initial production rate of fructose 6-phosphate (F6P) was determined with different types of fine-tuning linkers.	fructose-6-phosphate	209-229	triosephosphate isomerase 1	Homo sapiens	67-92
31874685-4	2020	In this study, a scaffoldin-mediated two-enzyme complex containing triosephosphate isomerase (TIM) and fructose-1,6-bisphosphate aldolase/phosphatase (FBPA) was constructed, and the initial production rate of fructose 6-phosphate (F6P) was determined with different types of fine-tuning linkers.	fructose-6-phosphate	209-229	triosephosphate isomerase 1	Homo sapiens	94-97
31874685-4	2020	In this study, a scaffoldin-mediated two-enzyme complex containing triosephosphate isomerase (TIM) and fructose-1,6-bisphosphate aldolase/phosphatase (FBPA) was constructed, and the initial production rate of fructose 6-phosphate (F6P) was determined with different types of fine-tuning linkers.	fructose-6-phosphate	231-234	triosephosphate isomerase 1	Homo sapiens	67-92
31874685-4	2020	In this study, a scaffoldin-mediated two-enzyme complex containing triosephosphate isomerase (TIM) and fructose-1,6-bisphosphate aldolase/phosphatase (FBPA) was constructed, and the initial production rate of fructose 6-phosphate (F6P) was determined with different types of fine-tuning linkers.	fructose-6-phosphate	231-234	triosephosphate isomerase 1	Homo sapiens	94-97
31874685-8	2020	The synthetic enzyme complex with the semirigid linker FRRRF in scaffoldin showed the highest initial F6P production rate of 10.16 muM/min, which indicates that the linker"s amino acid composition in scaffoldin may lead to significant changes in the spatial architecture of the TIM-FBPA complex and consequently affect the initial reaction rate.	fructose-6-phosphate	102-105	latexin	Homo sapiens	131-134
31874685-8	2020	The synthetic enzyme complex with the semirigid linker FRRRF in scaffoldin showed the highest initial F6P production rate of 10.16 muM/min, which indicates that the linker"s amino acid composition in scaffoldin may lead to significant changes in the spatial architecture of the TIM-FBPA complex and consequently affect the initial reaction rate.	fructose-6-phosphate	102-105	triosephosphate isomerase 1	Homo sapiens	278-281
32615907-1	2020	Glutamine: fructose-6-phosphate amidotransferase (GFAT) enzymes catalyse the first committed step of the hexosamine biosynthesis pathway (HBP) using glutamine and fructose-6-phosphate to form glucosamine-6-phosphate (GlcN6P).	fructose-6-phosphate	11-31	Glutamine:fructose-6-phosphate aminotransferase 1	Drosophila melanogaster	50-54
31133865-2	2019	Glucose-6-phosphate isomerase (GPI, EC 5.3.1.9) is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second reaction step of glycolysis.	fructose-6-phosphate	138-158	glucose-6-phosphate isomerase	Homo sapiens	0-29
31394311-6	2019	Glucose-6-phosphate isomerase (GPI), a rate-limiting enzyme converting glucose-6-phosphate to fructose-6-phosphate, was found to be significantly decreased in asthenozoospermia by Western blotting and ELISA on an extended sample size.	fructose-6-phosphate	94-114	glucose-6-phosphate isomerase	Homo sapiens	0-29
31394311-6	2019	Glucose-6-phosphate isomerase (GPI), a rate-limiting enzyme converting glucose-6-phosphate to fructose-6-phosphate, was found to be significantly decreased in asthenozoospermia by Western blotting and ELISA on an extended sample size.	fructose-6-phosphate	94-114	glucose-6-phosphate isomerase	Homo sapiens	31-34
31394311-11	2019	The supplement of the product of GPI, fructose-6-phosphate, could significantly improve sperm motility.	fructose-6-phosphate	38-58	glucose-6-phosphate isomerase	Homo sapiens	33-36
30918224-1	2019	Phosphofructokinase-1 (EC:2.7.1.11, PFK-1) catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using adenosine triphosphate and is a key regulatory enzyme of glycolysis.	fructose-6-phosphate	76-96	phosphofructokinase, muscle	Canis lupus familiaris	0-21
30918224-1	2019	Phosphofructokinase-1 (EC:2.7.1.11, PFK-1) catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using adenosine triphosphate and is a key regulatory enzyme of glycolysis.	fructose-6-phosphate	76-96	phosphofructokinase, muscle	Homo sapiens	36-41
32259054-10	2019	Other sugar phosphates, including glucose-1-phosphate, glucose-6-phosphate, fructose-6-phosphate, and fructose-1,6-bisphosphate, also potentiated PTH-induced adenylyl cyclase activation.	fructose-6-phosphate	76-96	parathyroid hormone	Rattus norvegicus	146-149
31474665-5	2019	In order to compare gluconeogenesis in canine liver and kidney, the activity and expression of the rate limiting enzymes that catalyze the fructose-6-phosphate and fructose 1,6-bisphosphate steps, namely, phosphofructokinase-1 (PFK-1) (glycolysis) and fructose bisphosphatase-1 (FBP-1) (gluconeogenesis), were examined.	fructose-6-phosphate	139-159	phosphofructokinase, muscle	Canis lupus familiaris	205-226
31133865-2	2019	Glucose-6-phosphate isomerase (GPI, EC 5.3.1.9) is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second reaction step of glycolysis.	fructose-6-phosphate	138-158	glucose-6-phosphate isomerase	Homo sapiens	31-34
30771196-2	2019	Glycolysis and glutaminolysis can be linked by glutamine: fructose-6-phosphate aminotransferase (GFAT, composed of GFAT1 and GFAT2) that catalyzes the synthesis of glucosamine-6-phosphate and glutamate by using fructose-6-phosphate and glutamine as substrates.	fructose-6-phosphate	58-78	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	97-101
31063150-2	2019	PMI is a zinc-dependent enzyme that catalyses the reversible isomerization between mannose 6-phosphate (M6P) and fructose 6-phosphate (F6P), presumably via the formation of a cis-enediol intermediate.	fructose-6-phosphate	113-133	mannose phosphate isomerase	Homo sapiens	0-3
31063150-2	2019	PMI is a zinc-dependent enzyme that catalyses the reversible isomerization between mannose 6-phosphate (M6P) and fructose 6-phosphate (F6P), presumably via the formation of a cis-enediol intermediate.	fructose-6-phosphate	135-138	mannose phosphate isomerase	Homo sapiens	0-3
30462889-5	2019	RESULTS: CaMK4 inhibition significantly decreased the levels of glycolytic intermediates such as glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, pyruvate, and lactate (P < 0.05), whereas it did not affect the levels of the pentose phosphate pathway intermediates such as 6-phospho-d-gluconate, ribulose-5-phosphate, ribose-5-phosphate, and phosphoribosyl pyrophosphate.	fructose-6-phosphate	118-138	calcium/calmodulin dependent protein kinase IV	Homo sapiens	9-14
30771196-2	2019	Glycolysis and glutaminolysis can be linked by glutamine: fructose-6-phosphate aminotransferase (GFAT, composed of GFAT1 and GFAT2) that catalyzes the synthesis of glucosamine-6-phosphate and glutamate by using fructose-6-phosphate and glutamine as substrates.	fructose-6-phosphate	58-78	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	115-120
30771196-2	2019	Glycolysis and glutaminolysis can be linked by glutamine: fructose-6-phosphate aminotransferase (GFAT, composed of GFAT1 and GFAT2) that catalyzes the synthesis of glucosamine-6-phosphate and glutamate by using fructose-6-phosphate and glutamine as substrates.	fructose-6-phosphate	58-78	glutamine-fructose-6-phosphate transaminase 2	Homo sapiens	125-130
30234009-8	2018	The fructose-6-phosphate/fructose-1,6-bisphosphate cycle, catalyzed by 6-phosphofructo-1-kinase/fructose 1,6-bisphosphatase (PFK1/FBPase1) isoenzymes, plays a key role in controlling glycolytic rates.	fructose-6-phosphate	4-24	phosphofructokinase, muscle	Homo sapiens	125-129
30246938-6	2018	Fusing Mdh with Hps or Hps-Phi increased the Vmax of methanol oxidation up to 5.8-fold, and enhanced methanol conversion to fructose-6-phosphate up to 1.3-fold.	fructose-6-phosphate	124-144	malate dehydrogenase 2	Homo sapiens	7-10
30464597-1	2018	Background: Glucose-6-phosphate isomerase (GPI) is a glycolytic-related enzyme that inter-converts glucose-6-phosphate and fructose-6-phosphate in the cytoplasm.	fructose-6-phosphate	123-143	glucose-6-phosphate isomerase	Homo sapiens	12-41
30464597-1	2018	Background: Glucose-6-phosphate isomerase (GPI) is a glycolytic-related enzyme that inter-converts glucose-6-phosphate and fructose-6-phosphate in the cytoplasm.	fructose-6-phosphate	123-143	glucose-6-phosphate isomerase	Homo sapiens	43-46
30234009-8	2018	The fructose-6-phosphate/fructose-1,6-bisphosphate cycle, catalyzed by 6-phosphofructo-1-kinase/fructose 1,6-bisphosphatase (PFK1/FBPase1) isoenzymes, plays a key role in controlling glycolytic rates.	fructose-6-phosphate	4-24	fructose-bisphosphatase 1	Homo sapiens	130-137
29870677-6	2018	In addition, the observation of significant levels of fructose-6-phosphate in skeletal muscle tissue of Khk KO, but not WT, mice suggests a potential mechanism, whereby fructose is metabolized via muscle hexokinase in the absence of KHK.	fructose-6-phosphate	54-74	ketohexokinase	Mus musculus	104-107
28834297-3	2017	PFKFB3 is a homodymeric bifunctional enzyme, belonging to the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases, that controls the conversion of fructose-6-phosphate (Fru-6-P) to fructose-2,6-bisphosphate (Fru-2,6-P2 ).	fructose-6-phosphate	159-179	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	0-6
29016355-2	2017	FBPase is encoded by FBP1 gene and catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate in the last step of gluconeogenesis.	fructose-6-phosphate	92-112	fructose-bisphosphatase 1	Homo sapiens	21-25
29507044-2	2018	Gluconeogenesis requires FBP2, a muscle-specific form of fructose bisphosphatase that converts fructose-1,6-bisphosphate (F-1,6-bisP) to fructose-6-phosphate (F-6-P) opposing the activity of the ATP-consuming enzyme phosphofructokinase (PFK).	fructose-6-phosphate	137-157	fructose-bisphosphatase 2	Rattus norvegicus	25-29
29507044-2	2018	Gluconeogenesis requires FBP2, a muscle-specific form of fructose bisphosphatase that converts fructose-1,6-bisphosphate (F-1,6-bisP) to fructose-6-phosphate (F-6-P) opposing the activity of the ATP-consuming enzyme phosphofructokinase (PFK).	fructose-6-phosphate	159-164	fructose-bisphosphatase 2	Rattus norvegicus	25-29
29507044-4	2018	In an attempt to increase substrate cycling between F-6-P and F-1,6-bisP and alter glucose metabolism, we overexpressed FBP2 using a muscle-specific adeno-associated virus (AAV-tMCK-FBP2).	fructose-6-phosphate	52-57	fructose-bisphosphatase 2	Rattus norvegicus	120-124
28834297-3	2017	PFKFB3 is a homodymeric bifunctional enzyme, belonging to the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases, that controls the conversion of fructose-6-phosphate (Fru-6-P) to fructose-2,6-bisphosphate (Fru-2,6-P2 ).	fructose-6-phosphate	159-179	zinc finger and BTB domain containing 22	Homo sapiens	181-184
28834297-3	2017	PFKFB3 is a homodymeric bifunctional enzyme, belonging to the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases, that controls the conversion of fructose-6-phosphate (Fru-6-P) to fructose-2,6-bisphosphate (Fru-2,6-P2 ).	fructose-6-phosphate	159-179	zinc finger and BTB domain containing 22	Homo sapiens	220-223
28644127-5	2017	These phenotypes are caused by induction of p53 and accumulation of the glycolytic intermediate fructose 6-phosphate, leading to engagement of the hexosamine biosynthetic pathway (HBP), increased O-GlcNAcylation, and p53 stabilization.	fructose-6-phosphate	96-116	tumor protein p53	Homo sapiens	217-220
28545955-2	2017	The phosphofructokinase1 (PFK1), which converts fructose-6-phosphate to fructose-1, 6-bisphosphate, is the major regulatory enzyme of the glycolytic pathway.	fructose-6-phosphate	48-68	phosphofructokinase, muscle	Homo sapiens	4-24
28545955-2	2017	The phosphofructokinase1 (PFK1), which converts fructose-6-phosphate to fructose-1, 6-bisphosphate, is the major regulatory enzyme of the glycolytic pathway.	fructose-6-phosphate	48-68	phosphofructokinase, muscle	Homo sapiens	26-30
28516783-2	2017	Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex.	fructose-6-phosphate	20-40	glucokinase	Homo sapiens	90-93
28516783-2	2017	Metabolites such as fructose 6-phosphate and sorbitol 6-phosphate promote assembly of the GCK-GKRP complex, whereas fructose 1-phosphate and functionalized piperazines with potent in vivo antidiabetic activity disrupt the complex.	fructose-6-phosphate	20-40	glucokinase regulator	Homo sapiens	94-98
27802586-3	2017	Citrate, a TCA cycle intermediate and well-known inhibitor of PFKFB2, co-crystallized in the 2-kinase domains of both orthologues, occupying the fructose-6-phosphate binding-site and extending into the gamma-phosphate binding pocket of ATP.	fructose-6-phosphate	145-165	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	Homo sapiens	62-68