PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9893658-1	1998	S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1:0.4:1, based on the biochemical modulation of 5-fluorouracil (5-FU).	oxo	102-105	proteasome 26S subunit, non-ATPase 1	Homo sapiens	0-3
15206768-6	2003	A general limitation of dinitrophenylhydrazine method is the interference of hydrazones formed from the coenzyme pyridoxal-5"-phosphate and from the oxo- substrate 2-oxoglutarate, showing the absorption maxima at 492 nm and 388 nm, respectively with the hydrazones formed by the oxo- products (pyruvate and/or oxaloacetate in the case of ALT/AST, the absorption maxima at 443 nm in our measurements).	oxo	149-152	AST	Sus scrofa	342-345
10200174-2	1999	Flash-induced reduction of the peroxy intermediate (P) to the ferryl-oxo state (F) by tris-bipyridyl complex of Ru(II) in liposome-reconstituted COX is coupled to several phases of membrane potential generation that have been time-resolved with the use of an electrometric technique applied earlier in the studies of the ferryl-oxo-to-oxidized (F --> O) transition of the enzyme [Zaslavsky, D., et al.	oxo	69-72	cytochrome c oxidase subunit 7A1	Bos taurus	145-148
12685650-2	2003	For N2-hydroxyisocytosine isolated in an Ar matrix (at 10 K), two imino-oxo isomers, one with the hydroxyimino =N-OH group directed toward the N1-H group (the form called further anti) and the second with the =N-OH group directed toward N3-H (syn), were observed in the ratio 1.4:1.	oxo	72-75	synemin	Homo sapiens	243-246
12899533-6	2003	Ligand-binding assays reveal that both Ro 25-4020 and its 24-oxo metabolite have similar affinity for VDR.	oxo	61-64	vitamin D receptor	Homo sapiens	102-105
10790998-1	2000	S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1:0.4:1, based on the biochemical modulation of 5-fluorouracil (5-FU).	oxo	102-105	eukaryotic translation elongation factor 1 alpha 2	Mus musculus	0-3
9893658-4	1998	S-1 improves the tumour-selective toxicity of 5-FU by the actions of two modulators, CDHP and Oxo.	oxo	94-97	proteasome 26S subunit, non-ATPase 1	Homo sapiens	0-3
9679577-8	1998	Based on these findings, it was concluded that S-1 is a useful anticancer agent with the low grade toxicities for treatment of the patients with advanced head and neck cancer, and the effects of CDHP and Oxo found in preclinical studies might be also reflected in these results.	oxo	204-207	proteasome 26S subunit, non-ATPase 1	Homo sapiens	47-50
28665322-4	2017	In 8-oxo-G:A mispairs generated by the incorporation of A opposite unrepaired 8-oxo-G, A is removed by MutYH (MYH) for post-replicative repair, and other oxidized base lesions must be repaired prior to replication in order to prevent mutation fixation.	oxo	5-8	mutY DNA glycosylase	Homo sapiens	103-108
11669688-0	1997	Density Functional Calculations of Electronic Structure, Charge Distribution, and Spin Coupling in Manganese-Oxo Dimer Complexes.	oxo	109-112	spindlin 1	Homo sapiens	82-86
2709381-3	1989	Use of this methodology furnished a simple and direct route to the beta-D-ribofuranosyl, beta-D-arabinofuranosyl, and 2-deoxy-beta-D-erythro-pentofuranosyl nucleosides of C-4 substituted pyrazolo[3,4-b]pyridines, wherein the C-4 substituent was azido, amino, methoxy, chloro, or oxo.	oxo	279-282	complement C4A (Rodgers blood group)	Homo sapiens	171-174
2709381-3	1989	Use of this methodology furnished a simple and direct route to the beta-D-ribofuranosyl, beta-D-arabinofuranosyl, and 2-deoxy-beta-D-erythro-pentofuranosyl nucleosides of C-4 substituted pyrazolo[3,4-b]pyridines, wherein the C-4 substituent was azido, amino, methoxy, chloro, or oxo.	oxo	279-282	complement C4A (Rodgers blood group)	Homo sapiens	225-228
2908227-5	1988	This reduction in activity is attributed to altered orientation of the dipole due to the presence of the C-6 oxo substituent, and/or to the overall effect of oxo in decreasing lipophilicity.	oxo	109-112	complement component C6	Cavia porcellus	105-108
6896331-6	1982	Based on kinetic studies with chick intestinal homogenates, the proposed C-23 oxidation pathway is: 1,25(OH)2D3 leads to 1,25(OH)2-23-oxo-D3 leads to 1,25,26(OH)3-23-oxo-D3 leads to unknown metabolite with altered side chain.	oxo	134-137	dopamine receptor D3	Gallus gallus	109-111
30350897-1	2018	This work focuses on nucleophilic activation of CO2 at the anionic terminal oxo titanium tris(anilide) complexes [(Solv)n M][OTi(N[t Bu]Ar)3 ]m with M=Li, Na, K, Mg, MgMe, AlCl2 , AlI2 ; Ar=3,5-Me2 C6 H3 ; Solv=Et2 O, THF, 12-crown-4, 2,2,2-cryptand; n, m=1-2.	oxo	76-79	adhesion molecule with Ig like domain 1	Homo sapiens	180-184
28834001-0	2017	Corrigendum: Spectroscopic Capture and Reactivity of a Low-Spin Cobalt(IV)-Oxo Complex Stabilized by Binding Redox-Inactive Metal Ions.	oxo	75-78	spindlin 1	Homo sapiens	59-63
8704640-2	1996	Oxo and tioxo derivatives of OPh with O-methyl and O-ethyl, but not O-propyl and O-butyl radicals at phosphoric atom prevented the lethality of mice poisoned with phosphacolum and preserved brain and blood ChE of inhibition.	oxo	0-3	butyrylcholinesterase	Mus musculus	206-209
28665322-4	2017	In 8-oxo-G:A mispairs generated by the incorporation of A opposite unrepaired 8-oxo-G, A is removed by MutYH (MYH) for post-replicative repair, and other oxidized base lesions must be repaired prior to replication in order to prevent mutation fixation.	oxo	5-8	mutY DNA glycosylase	Homo sapiens	110-113
28125220-0	2017	Chasing the Evasive Fe O Stretch and the Spin State of the Iron(IV)-Oxo Complexes by Photodissociation Spectroscopy.	oxo	68-71	spindlin 1	Homo sapiens	41-45
28257202-2	2017	The rhenium(V) oxo complex oxo(triphenylphosphine) (bis(3,5-di-tert-butyl-2-phenoxo)amido)rhenium(V), (ONOCat)ReO(PPh3), reacts with molecular oxygen to give triphenylphosphine oxide and the dimeric rhenium(VII) complex fac,anti-(ONOCat)Re(O)(mu-O)2Re(O)(ONOCat).	oxo	15-18	caveolin 1	Homo sapiens	114-118
28125220-3	2017	Furthermore, we show the assignment of the spin state of the complexes based on the vibrational modes of a coordinated anion and compare reactivities of various iron(IV)-oxo complexes generated as dications or monocations (bearing an anionic ligand).	oxo	170-173	spindlin 1	Homo sapiens	43-47
26206156-3	2015	The mu-oxo-bridged secondary building unit, {Cd2 (mu-OCO)2 }, guides the parallel alignment of bpNDI (N,N"-di(4-pyridyl)-1,4,5,8-naphthalenediimide) acceptor linkers, which are tethered with bpdc (bpdcH2 =4,4"-biphenyldicarboxylic acid) linkers of another entangled net in the framework, resulting in photochromic behaviour through inter-net electron transfer.	oxo	7-10	CD2 molecule	Homo sapiens	45-48
27348090-1	2016	A 2.4-A-resolution X-ray crystal structure of the carrier-protein-independent halogenase WelO5 in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-oxo-iron(IV) (haloferryl) intermediate.	oxo	261-264	homeobox C13	Homo sapiens	194-197
26816269-7	2016	On the basis of mechanistic studies, we conclude that mononuclear nonheme high-spin iron(III)-acylperoxo complexes are strong oxidants capable of oxygenating hydrocarbons prior to their conversion into iron-oxo species via O-O bond cleavage.	oxo	101-104	spindlin 1	Homo sapiens	79-83
26073059-3	2015	For this iron-oxo core, the magnetic susceptibility analysis proposed a Heisenberg-Dirac-van Vleck (HDvV) mechanism that leads to an intermediate spin ground state of S=7/2 or 9/2.	oxo	14-17	spindlin 1	Homo sapiens	146-150
25601767-0	2015	Spin-glass behavior of a hierarchically-organized, hybrid microporous material, based on an extended framework of octanuclear iron-oxo units.	oxo	131-134	spindlin 1	Homo sapiens	0-4
25400523-2	2014	The conventional mechanism for the dealkylation of N1-methyl adenine (1-meA) catalyzed by AlkB after the formation of FeIV-oxo is comprised by a reorientation of the oxo moiety, hydrogen abstraction, OH rebound from the Fe atom to the methyl adduct, and the dissociation of the resulting methoxide to obtain the repaired adenine base and formaldehyde.	oxo	123-126	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	90-94
24893882-6	2014	CYP24A1 exhibited Km values for the different C24-intermediates ranging from 0.34 to 15 mmol mol phospholipid(-1) , with 24-oxo-1,23,25-trihydroxyvitamin D3 [24-oxo-1,23,25(OH)3 D3] displaying the lowest and 1,24,25-trihydroxyvitamin D3 [1,24,25(OH)3 D3] displaying the highest.	oxo	124-127	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	0-7
24492533-2	2014	In this work, the reactions of C-H bond activation by two series of iron-oxo ( (Fe(IV)), (Fe(V)), (Fe(VI))) and -nitrido model complexes ( (Fe(IV)), (Fe(V)), (Fe(VI))) with a nearly identical coordination geometry but varying iron oxidation states ranging from iv to vi were comprehensively investigated using density functional theory.	oxo	73-76	FEV transcription factor, ETS family member	Homo sapiens	149-155
23400226-4	2013	An oxo-bridged, dimeric nitridorhenium(V) compound of the composition [{ReN(HL1)}2O] (11) is obtained from a reaction of (NBu4)[ReOCl4], H2L1 and sodium azide.	oxo	3-6	renin	Homo sapiens	72-75
23914844-4	2013	OXO inhibited the expression of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner.	oxo	0-3	nitric oxide synthase 2, inducible	Mus musculus	44-48
23914844-4	2013	OXO inhibited the expression of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner.	oxo	0-3	cytochrome c oxidase II, mitochondrial	Mus musculus	53-58
23914844-5	2013	Also, TNF-alpha, IL-6, and PGE2 secretion was decreased by OXO in LPS-stimulated macrophages.	oxo	59-62	tumor necrosis factor	Mus musculus	6-15
23914844-5	2013	Also, TNF-alpha, IL-6, and PGE2 secretion was decreased by OXO in LPS-stimulated macrophages.	oxo	59-62	interleukin 6	Mus musculus	17-21
23914844-7	2013	Moreover, OXO inhibited LPS-induced intracellular reactive oxygen species (ROS) production and co-incubation of OXO and hydrogen peroxide (H2O2) suppressed the phosphorylation of p38 in a concentration-dependent manner.	oxo	10-13	mitogen-activated protein kinase 14	Mus musculus	179-182
23914844-9	2013	Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway.	oxo	36-39	TNF receptor-associated factor 6	Mus musculus	156-161
23914844-9	2013	Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway.	oxo	36-39	mitogen-activated protein kinase kinase kinase 5	Mus musculus	162-166
23914844-9	2013	Therefore, we demonstrate here that OXO can potentially inhibit several biomarkers related to inflammation through inhibition of ROS-mediated activation of TRAF6-ASK1-p38 pathway.	oxo	36-39	mitogen-activated protein kinase 14	Mus musculus	167-170
23634216-5	2013	The reduction of camphor and simultaneous oxidation of water are likely catalyzed by the iron-oxo intermediate of P450(cam) , and we present a plausible mechanism that accounts for the 1:1 borneol:H2O2 stoichiometry we observed.	oxo	94-97	calmodulin 3	Homo sapiens	114-123
22505053-1	2012	Trapped in a noble cube: A novel family of noble metalates has been discovered in which a 3d metal ion M (M = Mn(II), Fe(III), Co(II), Cu(II), Zn(II)) is encapsulated by a 12 palladium-oxo cage {Pd(12)O(32)}, which is capped by eight phosphate groups.	oxo	185-188	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	127-133
21725553-5	2011	Solid-state structures of the molybdenum and tungsten cis-dioxo complexes reveal hexa-coordinate metal centers surrounded by two oxo groups, a chloride ligand and by the tridentate monophenolate ligand which coordinates meridionally through its [ONN] donor set.	oxo	60-63	hexosaminidase subunit alpha	Homo sapiens	81-85
18205303-0	2008	Porous metal-organic framework based on mu4-oxo tetrazinc clusters: sorption and guest-dependent luminescent properties.	oxo	44-47	adaptor related protein complex 4 subunit mu 1	Homo sapiens	40-43
17315920-1	2007	HO-(TPA)FeV=O (TPA = tris(2-pyridylmethyl)amine) has been proposed in the literature as the key high-valent iron-oxo intermediate involved in alkane hydroxylation.	oxo	113-116	plasminogen activator, tissue type	Homo sapiens	4-7
18680118-0	2008	Spin state, structure, and reactivity of terminal oxo and dioxygen complexes of the (PNP)Rh moiety.	oxo	50-53	spindlin 1	Homo sapiens	0-4
17315920-1	2007	HO-(TPA)FeV=O (TPA = tris(2-pyridylmethyl)amine) has been proposed in the literature as the key high-valent iron-oxo intermediate involved in alkane hydroxylation.	oxo	113-116	plasminogen activator, tissue type	Homo sapiens	15-18
16749848-2	2006	Complex 2 upon treatment with 1 equiv of alkali produces the oxo-bridged dimer [{Fe(LH2)(H2O)}2(mu-O)](ClO4)4.2H2O (3).	oxo	61-64	LIM homeobox 2	Homo sapiens	84-87
16714370-2	2006	A number of hypotheses have been advanced which implicate a second oxidant besides the iron-oxo species designated as compound I (Cpd 1).	oxo	92-95	cerebellar ataxia, infantile nonprogressive, autosomal recessive	Homo sapiens	130-135
16278042-15	2006	Therefore, the protective effect of Oxo on 5-FU-induced GI tract toxicity was clarified by measuring plasma DAO activity in rats.	oxo	36-39	amine oxidase, copper containing 1	Rattus norvegicus	108-111
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	oxo	140-143	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	44-47
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	oxo	140-143	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	oxo	140-143	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
16247826-5	2005	Finally, we have shown that the presence of ArI in a reaction solution containing 1 and H(2)18O facilitates the oxygen exchange between the oxo group of 1 and H(2)18O and that the oxygen exchange is markedly influenced by factors such as ArI incubation time, the amounts of ArI and H(2)18O used, and the electronic nature of ArI.	oxo	140-143	ariadne RBR E3 ubiquitin protein ligase 1	Homo sapiens	238-241
15187385-0	2004	Syntheses of 10-oxo, 10 alpha-hydroxy, and 10 beta-hydroxy derivatives of a potent kappa-opioid receptor agonist, TRK-820.	oxo	16-19	neurotrophic receptor tyrosine kinase 1	Homo sapiens	114-117
16323936-4	2005	Upon reaction of LLi2 with [Ti(NMe2)2Cl2] and water, the mu-oxo-bridged dititanium species [L[Ti(NMe2)Cl]2(mu-O)] is obtained in excellent yield (X-ray crystal structure analysis).	oxo	60-63	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	31-35
16323936-4	2005	Upon reaction of LLi2 with [Ti(NMe2)2Cl2] and water, the mu-oxo-bridged dititanium species [L[Ti(NMe2)Cl]2(mu-O)] is obtained in excellent yield (X-ray crystal structure analysis).	oxo	60-63	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	97-101
15824782-10	2005	The reduction of [V(V)(O)2(tpa)]+ in 0.05 M [(n-Bu)4N]PF6 acetonitrile showed a major irreversible reduction wave V(V)/(IV) at -1.48 V. The metal reduction potentials of the oxovanadium(IV) and dioxovanadium(V) species are very close, reinforcing the significant influence of the oxo ligand(s).	oxo	174-177	sperm associated antigen 17	Homo sapiens	54-57
15686361-2	2005	Spectroscopic characterization of the catalytically competent iron-oxo species in iodosobenzene (PhIO)-supported model reactions and parallels between these model reactions and PhIO- and NADPH/O2-supported P450 reactions have been taken as strong evidence for this proposal.	oxo	67-70	2,4-dienoyl-CoA reductase 1	Homo sapiens	187-192