PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23437193-11 2013 Increased of reactive oxygen species (ROS) production, coupled with downregulation of anti-apoptotic molecules (Bcl-2, Bcl-xL) led to reduction of mitochondrial membrane potential (MMP) and release of cytochrome c in both human breast cancer cells treated with vernodalin. vernodalin 261-271 BCL2 apoptosis regulator Homo sapiens 112-117 32726518-0 2020 Vernodalin induces apoptosis through the activation of ROS/JNK pathway in human colon cancer cells. vernodalin 0-10 mitogen-activated protein kinase 8 Homo sapiens 59-62 32726518-6 2020 Small interfering RNA was used to analyze the cascade activation of mitogen-activated protein kinase (MAPK) pathway, c-Jun N-terminal kinase (JNK) in HT-29, and HCT116 cells against vernodalin treatment. vernodalin 182-192 mitogen-activated protein kinase 8 Homo sapiens 117-140 32726518-6 2020 Small interfering RNA was used to analyze the cascade activation of mitogen-activated protein kinase (MAPK) pathway, c-Jun N-terminal kinase (JNK) in HT-29, and HCT116 cells against vernodalin treatment. vernodalin 182-192 mitogen-activated protein kinase 8 Homo sapiens 142-145 32726518-8 2020 Immunoblot analysis on the JNK, ERK, and p38 MAPK pathways showed increased activation due to vernodalin treatment. vernodalin 94-104 mitogen-activated protein kinase 8 Homo sapiens 27-30 32726518-8 2020 Immunoblot analysis on the JNK, ERK, and p38 MAPK pathways showed increased activation due to vernodalin treatment. vernodalin 94-104 mitogen-activated protein kinase 1 Homo sapiens 32-35 32726518-9 2020 It was proven from the JNK and p38 inhibition test that both pathways are significantly activated by vernodalin to induce apoptosis. vernodalin 101-111 mitogen-activated protein kinase 8 Homo sapiens 23-26 32726518-9 2020 It was proven from the JNK and p38 inhibition test that both pathways are significantly activated by vernodalin to induce apoptosis. vernodalin 101-111 mitogen-activated protein kinase 14 Homo sapiens 31-34 23437193-11 2013 Increased of reactive oxygen species (ROS) production, coupled with downregulation of anti-apoptotic molecules (Bcl-2, Bcl-xL) led to reduction of mitochondrial membrane potential (MMP) and release of cytochrome c in both human breast cancer cells treated with vernodalin. vernodalin 261-271 cytochrome c, somatic Homo sapiens 201-213