PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 24906456-10 2014 O2-induced phosphorylation of EGFR occurred within 5 min of increasing pO2 and was inhibited by mitochondrial-targeted overexpression of catalase. PO-2 71-74 epidermal growth factor receptor Homo sapiens 30-34 24607773-11 2014 Dual ETA/ETB blockade did not significantly increase microvascular flow but improved transcutaneous pO2. PO-2 100-103 endothelin receptor type A Homo sapiens 5-8 24607773-11 2014 Dual ETA/ETB blockade did not significantly increase microvascular flow but improved transcutaneous pO2. PO-2 100-103 endothelin receptor type B Homo sapiens 9-12 25324517-9 2014 The metabolically relevant dependence on pO2 is obtained by correcting for the increase in fred, in which case the P50 is 12 torr. PO-2 41-44 nuclear factor kappa B subunit 1 Homo sapiens 115-118 25209412-6 2014 At each depth below the cortical surface, tissue PO2 in LPK rats was approximately half that in Lewis rats. PO-2 49-52 pyruvate kinase L/R Rattus norvegicus 56-59 25209412-8 2014 Renal venous PO2 was 38% less in LPK than Lewis rats. PO-2 13-16 pyruvate kinase L/R Rattus norvegicus 33-36 25062272-8 2014 This allows Nox4 to generate H2O2 as a function of oxygen concentration throughout a physiological range of pO2 values and to respond rapidly to changes in pO2. PO-2 108-111 NADPH oxidase 4 Homo sapiens 12-16 25166211-4 2014 As expected, hypoxia (1% pO2) further induced HIF-1alpha protein levels along with its target genes VEGF and LOX. PO-2 25-28 hypoxia inducible factor 1 subunit alpha Homo sapiens 46-56 25166211-4 2014 As expected, hypoxia (1% pO2) further induced HIF-1alpha protein levels along with its target genes VEGF and LOX. PO-2 25-28 vascular endothelial growth factor A Homo sapiens 100-104 25166211-4 2014 As expected, hypoxia (1% pO2) further induced HIF-1alpha protein levels along with its target genes VEGF and LOX. PO-2 25-28 lysyl oxidase Homo sapiens 109-112 25062272-8 2014 This allows Nox4 to generate H2O2 as a function of oxygen concentration throughout a physiological range of pO2 values and to respond rapidly to changes in pO2. PO-2 156-159 NADPH oxidase 4 Homo sapiens 12-16 23934707-5 2013 Switching to HS (4% NaCl) diet for 3 days to reduce plasma renin activity (PRA) eliminated vasodilation to ACh and reduced PO2 in sham-operated controls, with no effect on vasodilation in 2K1C rats. PO-2 123-126 renin Rattus norvegicus 59-64 24205977-9 2014 For the GDH system, the mean relative differences were -0.3% and -0.2% at pO2 values <=45 mm Hg and >=150 mm Hg, respectively. PO-2 74-77 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 8-11 24729219-4 2014 Using electron paramagnetic resonance (EPR) to assess in vivo oxygen concentration in tumors repeatedly and non-invasively, we found that mNPH increased tumor pO2 from 3.5 to 68.8 mmHg on average for up to 10 days. PO-2 159-162 tensin 2 Mus musculus 138-142 24729223-6 2014 Preliminary studies for the BNIP3 knock out animals show extremely low pO2. PO-2 71-74 BCL2/adenovirus E1B interacting protein 3 Mus musculus 28-33 24462831-4 2014 Initial ELISA analysis of circulating BDNF in 30 healthy human volunteers showed that 72 h exposure to high altitude (~11,000 ft, alveolar PO2 = 100 mmHg) results in higher BDNF compared to samples taken at sea level. PO-2 139-142 brain derived neurotrophic factor Homo sapiens 173-177 23847732-2 2013 We demonstrate a combined optical system using two-photon phosphorescence lifetime and fluorescence microscopy (2PLM) to characterize the partial pressure of oxygen (pO2) in single descending cortical arterioles in the mouse brain before and after generating a targeted photothrombotic occlusion. PO-2 166-169 FXYD domain-containing ion transport regulator 1 Mus musculus 113-116 24351177-1 2013 BACKGROUND: Partial pressure of oxygen (pO2) in blood samples can affect blood glucose (BG) measurements, particularly in systems that employ the glucose oxidase (GOx) enzyme reaction on test strips. PO-2 40-43 hydroxyacid oxidase 1 Homo sapiens 146-161 24351177-1 2013 BACKGROUND: Partial pressure of oxygen (pO2) in blood samples can affect blood glucose (BG) measurements, particularly in systems that employ the glucose oxidase (GOx) enzyme reaction on test strips. PO-2 40-43 hydroxyacid oxidase 1 Homo sapiens 163-166 24351177-2 2013 In this study, we assessed the impact of different pO2 values on the performance of five GOx systems and one glucose dehydrogenase (GDH) system. PO-2 51-54 hydroxyacid oxidase 1 Homo sapiens 89-92 24351177-8 2013 For both pO2 levels, relative differences of all tested GOx systems were significant (p < .0001). PO-2 9-12 hydroxyacid oxidase 1 Homo sapiens 56-59 24351177-10 2013 CONCLUSIONS: These data suggest that capillary blood pO2 variations lead to clinically relevant BG measurement deviations in GOx systems, even in GOx systems that are not labeled as being oxygen sensitive. PO-2 53-56 hydroxyacid oxidase 1 Homo sapiens 125-128 24351177-10 2013 CONCLUSIONS: These data suggest that capillary blood pO2 variations lead to clinically relevant BG measurement deviations in GOx systems, even in GOx systems that are not labeled as being oxygen sensitive. PO-2 53-56 hydroxyacid oxidase 1 Homo sapiens 146-149 23798702-2 2013 S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4. PO-2 57-60 ryanodine receptor 1 Homo sapiens 15-19 23798702-2 2013 S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4. PO-2 57-60 NADPH oxidase 4 Homo sapiens 130-145 23798702-3 2013 In isolated SR (SR vesicles), an average of six to eight Cys thiols/RyR1 monomer are reversibly oxidized at high (21% O2) versus low pO2 (1% O2), but their identity among the 100 Cys residues/RyR1 monomer is unknown. PO-2 133-136 ryanodine receptor 1 Homo sapiens 68-72 23798702-4 2013 Here we use isotope-coded affinity tag labeling and mass spectrometry (yielding 93% coverage of RyR1 Cys residues) to identify 13 Cys residues subject to pO2-coupled S-oxidation in SR vesicles. PO-2 154-157 ryanodine receptor 1 Homo sapiens 96-100 23798702-5 2013 Eight additional Cys residues are oxidized at high versus low pO2 only when NADPH levels are supplemented to enhance NADPH oxidase 4 activity. PO-2 62-65 NADPH oxidase 4 Homo sapiens 117-132 23989819-8 2013 RESULTS: A significant negative correlation was found indicating higher S100beta release at lower Ht levels and at lower PO2 levels in all study groups. PO-2 121-124 S100 calcium binding protein B Homo sapiens 72-80 23762985-2 2013 Simvastatin at a concentration of 100 ng/ml increases p50 (the blood pO2 corresponding to its 50% oxygen saturation) at real values of pH and pCO2 from 39.53 + 2.41 (p <0.05) to 36.60 (36, 40, 37, 60) (p <0.05) mm Hg. PO-2 69-72 nuclear factor kappa B subunit 1 Homo sapiens 54-57 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 23-26 mechanistic target of rapamycin kinase Homo sapiens 66-95 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 23-26 mechanistic target of rapamycin kinase Homo sapiens 97-101 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 23-26 CREB regulated transcription coactivator 1 Mus musculus 114-120 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 23-26 mechanistic target of rapamycin kinase Homo sapiens 114-118 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 66-95 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 97-101 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 CREB regulated transcription coactivator 1 Mus musculus 114-120 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 114-118 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 66-95 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 97-101 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 CREB regulated transcription coactivator 1 Mus musculus 114-120 23530221-5 2013 We find that near 1.5% pO2, the signaling network associated with mammalian target of rapamycin (mTOR) complex 1 (mTORC1)--a critical component of hypoxic signaling and a compelling cancer drug target--is deregulated in a manner such that it will be unresponsive to mTOR kinase inhibitors near 1.5% pO2, but will respond at higher or lower pO2 values. PO-2 299-302 mechanistic target of rapamycin kinase Homo sapiens 114-118 23334390-1 2013 pO2 in the kidney is maintained at relatively stable levels by a unique and complex functional interplay between renal blood flow, GFR, O2 consumption, and arteriovenous O2 shunting. PO-2 0-3 Rap guanine nucleotide exchange factor 5 Homo sapiens 131-134 23287475-8 2013 Eventually this tumor contained 100% CD133(+) elements and pO(2)-dependent percentages of the three embryonic transcription factors Nanog, Klf4 and c-Myc. PO-2 59-64 Nanog homeobox Homo sapiens 132-137 23287475-8 2013 Eventually this tumor contained 100% CD133(+) elements and pO(2)-dependent percentages of the three embryonic transcription factors Nanog, Klf4 and c-Myc. PO-2 59-64 Kruppel like factor 4 Homo sapiens 139-143 23287475-8 2013 Eventually this tumor contained 100% CD133(+) elements and pO(2)-dependent percentages of the three embryonic transcription factors Nanog, Klf4 and c-Myc. PO-2 59-64 MYC proto-oncogene, bHLH transcription factor Homo sapiens 148-153 23158604-5 2013 RESULTS: Saturation of hemoglobin oxygen, HCO(3), pH, Pco(2), Po(2), and BE exhibited significant statistical correlation between ABG and CBG (P = .001). PO-2 62-67 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 138-141 23037900-1 2012 PURPOSE OF REVIEW: The present review aims to address the role of adipose tissue oxygen partial pressure (PO2) in the metabolic and endocrine derangements in conditions characterized by insulin resistance. PO-2 106-109 WD and tetratricopeptide repeats 1 Mus musculus 66-73 24089653-13 2013 Compared to PC1, PC2 exhibited lower pH, pO2, and Na(+) levels, a higher PLT count, and increased pCO2, K(+), Lac, and CD62P expression levels. PO-2 41-44 polycystin 2, transient receptor potential cation channel Homo sapiens 17-20 23037900-2 2012 RECENT FINDINGS: The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose tissue PO2. PO-2 123-126 WD and tetratricopeptide repeats 1 Mus musculus 37-44 23037900-2 2012 RECENT FINDINGS: The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose tissue PO2. PO-2 123-126 WD and tetratricopeptide repeats 1 Mus musculus 108-115 23037900-4 2012 However, conflicting data have been reported in humans, showing both increased and decreased adipose tissue PO2 in obese compared with lean individuals. PO-2 108-111 WD and tetratricopeptide repeats 1 Mus musculus 93-100 23037900-5 2012 Both low and high adipose tissue PO2 may induce a proinflammatory phenotype in (pre)adipocytes, but most studies have been performed under rather extreme PO2 levels, not reflecting human adipose tissue physiology. PO-2 33-36 WD and tetratricopeptide repeats 1 Mus musculus 18-25 23037900-6 2012 Furthermore, adipose tissue PO2 may affect glucose and lipid metabolism as well as adipogenic differentiation, but many issues still need to be addressed. PO-2 28-31 WD and tetratricopeptide repeats 1 Mus musculus 13-20 23037900-8 2012 Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype. PO-2 24-27 WD and tetratricopeptide repeats 1 Mus musculus 9-16 23037900-8 2012 Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype. PO-2 24-27 WD and tetratricopeptide repeats 1 Mus musculus 98-105 23037900-8 2012 Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype. PO-2 24-27 WD and tetratricopeptide repeats 1 Mus musculus 98-105 23037900-8 2012 Although adipose tissue PO2 seems to be involved in metabolic and endocrine derangements in human adipose tissue, future studies should investigate how low and high adipose tissue PO2 within the human physiological range (3-11% O2) relates to adipose tissue blood flow and oxygen consumption, cellular metabolic responses, and the inflammatory phenotype. PO-2 24-27 WD and tetratricopeptide repeats 1 Mus musculus 98-105 22747465-10 2012 The unusual kinetic pK(a) further suggested that PHD2 might function physiologically to sense both intracellular pO(2) as well as pH, which could provide for feedback between anaerobic metabolism and hypoxia sensing. PO-2 113-118 egl-9 family hypoxia inducible factor 1 Homo sapiens 49-53 22134773-4 2012 Using treatments with CoCl2 and HIF-1alpha shRNA knockdowns on non-sorted human primary glioblastoma cells cultured at low (3%) versus high (21%) oxygen tension, we established a responsibility for low pO2 in the maintenance of high levels of AC133 expression, with a major but non-exclusive role for HIF-1alpha. PO-2 238-241 hypoxia inducible factor 1 subunit alpha Homo sapiens 44-54 22275240-7 2012 Notch-1 intracellular domain (NICD) expression was significantly higher in synovial tissue from patients with tissue PO2 of <20 mm Hg (<3% O2) than in those with tissue PO2 of >20 mm Hg (>3% O2). PO-2 117-120 notch receptor 1 Homo sapiens 0-7 22275240-7 2012 Notch-1 intracellular domain (NICD) expression was significantly higher in synovial tissue from patients with tissue PO2 of <20 mm Hg (<3% O2) than in those with tissue PO2 of >20 mm Hg (>3% O2). PO-2 175-178 notch receptor 1 Homo sapiens 0-7 22134773-2 2012 Recently, it was demonstrated that increasing oxygen tension (pO2) down-regulated AC133 expression in glioblastoma cells in vitro. PO-2 74-77 prominin 1 Homo sapiens 94-99 22134773-4 2012 Using treatments with CoCl2 and HIF-1alpha shRNA knockdowns on non-sorted human primary glioblastoma cells cultured at low (3%) versus high (21%) oxygen tension, we established a responsibility for low pO2 in the maintenance of high levels of AC133 expression, with a major but non-exclusive role for HIF-1alpha. PO-2 238-241 prominin 1 Homo sapiens 279-284 22134773-4 2012 Using treatments with CoCl2 and HIF-1alpha shRNA knockdowns on non-sorted human primary glioblastoma cells cultured at low (3%) versus high (21%) oxygen tension, we established a responsibility for low pO2 in the maintenance of high levels of AC133 expression, with a major but non-exclusive role for HIF-1alpha. PO-2 238-241 hypoxia inducible factor 1 subunit alpha Homo sapiens 349-359 23097963-6 2012 Beta2-adrenergcic stimulator-Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p < 0.05) following the bronchoconstriction being provoked by Propranolol. PO-2 107-110 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 0-5 21642977-2 2011 Using two-photon phosphorescence lifetime microscopy (2PLM) and the oxygen probe PtP-C343, we show that PO(2) can be accurately measured in the brain at depths up to 300 mum with micron-scale resolution. PO-2 104-109 protein tyrosine phosphatase, non-receptor type 13 Rattus norvegicus 81-84 22768306-3 2012 Using in vivo and in vitro models, we evaluated the effect of reducing the partial pressure of oxygen (PO(2)) on NFAT5 activity. PO-2 103-109 nuclear factor of activated T-cells 5 Rattus norvegicus 113-118 21562317-1 2011 Alveolar edema and decreased inspired Po(2) decrease the oxygen supply to alveolar epithelia, impairing beta(2)-adrenergic receptor (beta2AR) signaling and alveolar reabsorption. PO-2 38-43 adrenoceptor beta 2 Rattus norvegicus 104-131 21562317-1 2011 Alveolar edema and decreased inspired Po(2) decrease the oxygen supply to alveolar epithelia, impairing beta(2)-adrenergic receptor (beta2AR) signaling and alveolar reabsorption. PO-2 38-43 adrenoceptor beta 2 Rattus norvegicus 133-140 21896730-3 2011 Reactive oxygen species are generated in proportion to pO(2) by NADPH oxidase 4 (Nox4) in the sarcoplasmic reticulum, and the consequent oxidation of a small set of RyR1 cysteine thiols results in increased RyR1 activity and Ca(2+) release in isolated sarcoplasmic reticulum and in cultured myofibers and enhanced contractility of intact muscle. PO-2 55-60 NADPH oxidase 4 Homo sapiens 64-79 21896730-3 2011 Reactive oxygen species are generated in proportion to pO(2) by NADPH oxidase 4 (Nox4) in the sarcoplasmic reticulum, and the consequent oxidation of a small set of RyR1 cysteine thiols results in increased RyR1 activity and Ca(2+) release in isolated sarcoplasmic reticulum and in cultured myofibers and enhanced contractility of intact muscle. PO-2 55-60 NADPH oxidase 4 Homo sapiens 81-85 19883227-7 2009 Untreated RIF-1 tumors were hypoxic with a tissue pO2 of 5-7 mmHg. PO-2 50-53 replication timing regulatory factor 1 Homo sapiens 10-15 21507469-5 2011 RESULTS: Renal PO(2) was inversely related to the IAP (P < .001). PO-2 15-20 Cd47 molecule Rattus norvegicus 50-53 20658111-8 2010 Moreover, the blood PO2 / FiO2 ratio was negatively correlated with the BNP (r is -0.79), NT-proBNP (r is -0.85) and ALI scores (r is -0.85). PO-2 20-23 natriuretic peptide B Rattus norvegicus 72-75 21445801-2 2011 In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo. PO-2 85-88 hypoxia inducible factor 1 subunit alpha Homo sapiens 116-121 21445801-2 2011 In vivo, capillary pO(2) and extracellular- and intracellular- O(2) gradients define pO2 at the O(2) labile subunit HIF-1alpha.With a novel technique for subcellular imaging of O(2) heterogeneity using GFP, the present study was undertaken to examine the possibility that changes in mitochondrial respiration significantly affect intracellular O(2) gradients and thus, HIF-1 expression.We failed to demonstrate consistent changes in intracellular O(2) distributions in cultured cells with different metabolic and morphological properties (COS-7, Hep G2, and Hep3B cells) while mitochondrial O(2) consumption was widely changed at 1%O(2).Thus,we conclude that conductance for intracellular diffusion of O(2) is high in these cells and intracellular O(2) gradients might not be involved in the regulation of HIF-1 expression in vivo. PO-2 85-88 hypoxia inducible factor 1 subunit alpha Homo sapiens 369-374 19822207-3 2010 Conflicting data exist regarding the effect of pO(2) on NADPH production via the oxidative pentose phosphate cycle (OPPC). PO-2 47-52 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 56-61 19641936-3 2009 However, it is not clear how the expression of MSR1 in macrophages is regulated by low pO2. PO-2 87-90 macrophage scavenger receptor 1 Mus musculus 47-51 19722378-9 2009 mPAP/CI abnormal location were associated with hypoxemia/decreased mixed venous-PO2 and lung mechanics abnormalities for both cohorts. PO-2 80-83 phospholipid phosphatase 1 Mus musculus 0-4 19555296-1 2009 Hypoxia-induced hyperventilation is critical to improve blood oxygenation, particularly when the arterial Po2 lies in the steep region of the O2 dissociation curve of the hemoglobin (ODC). PO-2 106-109 ornithine decarboxylase 1 Homo sapiens 183-186 19412833-8 2009 CONCLUSIONS: These studies demonstrate that insulin inhibits ATP release from erythrocytes in response to reduced pO(2) and impairs their ability to stimulate dilation of skeletal muscle arterioles. PO-2 114-119 insulin Homo sapiens 44-51 19091790-7 2009 Ad CuZnSOD decreased the baseline discharge (7.6 +/- 1.3 vs. 12.6 +/- 1.7 imp/s at approximately 100 mmHg PO2) and the response to hypoxia (22.4 +/- 1.6 vs. 32.3 +/- 1.2 imp/s at approximately 40 mmHg PO2, P < 0.05) in CHF rabbits. PO-2 106-109 superoxide dismutase [Cu-Zn] Oryctolagus cuniculus 3-10 19091790-7 2009 Ad CuZnSOD decreased the baseline discharge (7.6 +/- 1.3 vs. 12.6 +/- 1.7 imp/s at approximately 100 mmHg PO2) and the response to hypoxia (22.4 +/- 1.6 vs. 32.3 +/- 1.2 imp/s at approximately 40 mmHg PO2, P < 0.05) in CHF rabbits. PO-2 201-204 superoxide dismutase [Cu-Zn] Oryctolagus cuniculus 3-10 17449336-3 2007 The distribution of O(2) between dissolved (PO2) and hemoglobin-bound (saturation) is the familiar oxygen equilibrium curve, whose position is noted as P50. PO-2 44-47 nuclear factor kappa B subunit 1 Homo sapiens 152-155 19074987-9 2009 Of clinical importance, AT pO2 negatively correlated with CD68 mRNA and macrophage inflammatory protein 1alpha secretion (R = -0.58, R = -0.79, P < 0.05), suggesting that lower AT pO2 could drive AT inflammation in obesity. PO-2 27-30 CD68 molecule Homo sapiens 58-62 19074987-9 2009 Of clinical importance, AT pO2 negatively correlated with CD68 mRNA and macrophage inflammatory protein 1alpha secretion (R = -0.58, R = -0.79, P < 0.05), suggesting that lower AT pO2 could drive AT inflammation in obesity. PO-2 27-30 C-C motif chemokine receptor 1 Homo sapiens 72-110 18957686-7 2009 Instead, increased pO(2) led to alteration of lipid rafts by cholesterol depletion and structural changes and was associated with increased shedding of CXCR4-positive microparticles, suggesting a novel mechanism of CXCR4 regulation. PO-2 19-24 C-X-C motif chemokine receptor 4 Homo sapiens 152-157 18957686-7 2009 Instead, increased pO(2) led to alteration of lipid rafts by cholesterol depletion and structural changes and was associated with increased shedding of CXCR4-positive microparticles, suggesting a novel mechanism of CXCR4 regulation. PO-2 19-24 C-X-C motif chemokine receptor 4 Homo sapiens 215-220 18234893-6 2008 We conclude that the threshold of interstitial pO2 for robust CA3 network activities and required mitochondrial function is clearly above the "critical" value, which causes spreading depression as a result of generalized energy failure. PO-2 47-50 carbonic anhydrase 3 Homo sapiens 62-65 19053230-6 2008 Our results indicate that both RyR1 and RyR2 are pO(2)-responsive yet point to different mechanisms by which NO and S-nitrosoglutathione influence cardiac and skeletal muscle sarcoplasmic reticulum Ca(2+) release. PO-2 49-54 ryanodine receptor 1 Homo sapiens 31-35 19053230-6 2008 Our results indicate that both RyR1 and RyR2 are pO(2)-responsive yet point to different mechanisms by which NO and S-nitrosoglutathione influence cardiac and skeletal muscle sarcoplasmic reticulum Ca(2+) release. PO-2 49-54 ryanodine receptor 2 Homo sapiens 40-44 18805587-2 2008 These cellular responses to pO2 are largely controlled by enzymes that belong to the Fe(II) alpha-ketoglutarate (alphaKG) dependent dioxygenase superfamily, including the human enzyme called the factor inhibiting HIF (FIH-1), which couples O2-activation to the hydroxylation of the hypoxia inducible factor alpha (HIFalpha). PO-2 28-31 hypoxia inducible factor 1 subunit alpha inhibitor Homo sapiens 218-223 17406888-10 2007 End-tidal PO(2) was higher at PFCC compared to F18 h (10.4 +/- 1.2 vs. 9.5 +/- 1.2 kPa at PBP, P < 0.05). PO-2 10-15 dedicator of cytokinesis 3 Homo sapiens 90-93 17391951-9 2007 In addition, the IFN-gamma-1b group showed stability in arterial PO2 while the colchicine group significantly deteriorated (p=0.02). PO-2 65-68 interferon gamma Homo sapiens 17-26 17452336-0 2007 PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway. PO-2 0-5 ATP binding cassette subfamily B member 1 Homo sapiens 43-65 17876730-0 2007 Flap monitoring by transcutaneous PO2 and PCO2: importance of transcutaneous PCO2 in determining follow-up treatment for compromised free flaps. PO-2 34-37 arachidonate 5-lipoxygenase activating protein Homo sapiens 0-4 17452336-0 2007 PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway. PO-2 0-5 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 89-94 17353442-9 2007 In term DA, an increase in PO2 activates Rho-kinase and thereby increases RhoB and ROCK-1 expression. PO-2 27-30 rho-related GTP-binding protein RhoB Oryctolagus cuniculus 74-78 17353442-9 2007 In term DA, an increase in PO2 activates Rho-kinase and thereby increases RhoB and ROCK-1 expression. PO-2 27-30 rho-associated protein kinase 1 Oryctolagus cuniculus 83-89 17394854-6 2007 sTNFRI, IL-1Ra and ICAM-1 early showed significantly higher levels in relation with serum creatinine, and these and also IL-6 in those with PO2 below 60 mmHg. PO-2 140-143 interleukin 6 Homo sapiens 121-125 17218454-4 2007 Based on the DMb, the equipoise diffusion PO2, the PO2 in which Mb-facilitated and free O2 diffusion contribute equally to the O2 flux, varies from 2.72 to 0.15 in myocardium and from 7.27 to 4.24 mmHg in skeletal muscle. PO-2 42-45 RT1 class II, locus DMb Rattus norvegicus 13-16 17218454-4 2007 Based on the DMb, the equipoise diffusion PO2, the PO2 in which Mb-facilitated and free O2 diffusion contribute equally to the O2 flux, varies from 2.72 to 0.15 in myocardium and from 7.27 to 4.24 mmHg in skeletal muscle. PO-2 42-45 myoglobin Rattus norvegicus 14-16 17218454-6 2007 In skeletal muscle, Mb-facilitated diffusion begins to contribute significantly only when the PO2 approaches the P50. PO-2 94-97 myoglobin Rattus norvegicus 20-22 16616713-5 2006 In cells grown under osteoblastic differentiation conditions, the expression of the osteoblastic markers osteocalcin, bone sialoprotein, osterix, and Runx2 and alkaline phosphatase activity was upregulated when incubated in air; however, it was blocked at low (3%) pO2. PO-2 265-268 RUNX family transcription factor 2 Homo sapiens 150-155 17402592-2 2007 Nebivolol increased the values of p50 (pO2 at 50% hemoglobin saturation with oxygen) under real pH and pCO2 (by 4.3 +/- 0.8 mm Hg at the lowest concentration (p < 0.01). PO-2 39-42 nuclear factor kappa B subunit 1 Homo sapiens 34-37 16877017-1 2007 The present article was aimed at determining the alveolar-capillary PO2 difference (deltaP(AcO2)) during exercise. PO-2 68-71 aconitase 2 Homo sapiens 91-95 17049073-10 2006 Finally, our hypothesis that variations of pO2 could exist between adipose tissue from anatomical origins was supported by staining of the hypoxic-induced angiopoietin ANGPTL4 depended on the location of fat. PO-2 43-46 angiopoietin like 4 Homo sapiens 168-175 16821883-9 2006 Interaction with cortisol or the cortisol-ApoA-I complex leads to the formation of a hydrogen bond with the NH group of cytosine; in addition, THC and cortisol form hydrogen bonds with the PO2 group of the duplex and with the OH group of the monosaccharide. PO-2 189-192 apolipoprotein A1 Homo sapiens 42-48 16330260-7 2006 The difference was mainly due to a higher tidal volume that could explain a higher arterial PO2 in Epo-TAg(h) mice. PO-2 92-95 erythropoietin Mus musculus 99-102 16421206-1 2006 Myoglobin (Mb) has a purported role in facilitating O2 diffusion in tissue, especially as cellular PO2 drops or the respiration demand increases. PO-2 99-102 myoglobin Homo sapiens 0-9 16421206-1 2006 Myoglobin (Mb) has a purported role in facilitating O2 diffusion in tissue, especially as cellular PO2 drops or the respiration demand increases. PO-2 99-102 myoglobin Homo sapiens 11-13 16533775-10 2006 T/L pO2 correlated significantly with plasma osteopontin levels (r = 0.53, P = 0.02) and CA IX expression (P = 0.006). PO-2 4-7 secreted phosphoprotein 1 Homo sapiens 45-56 16533775-10 2006 T/L pO2 correlated significantly with plasma osteopontin levels (r = 0.53, P = 0.02) and CA IX expression (P = 0.006). PO-2 4-7 carbonic anhydrase 9 Homo sapiens 89-94 16784545-2 2006 This study, performed in a normotensive rat model of endotoxemia, tests the hypotheses that endotoxemia impairs renal microvascular PO2 (microPO2) and oxygen consumption (VO2,ren), that endotoxemia is associated with a diminished kidney function, that fluid resuscitation can restore microPO2, VO2,ren and kidney function, and that colloids are more effective than crystalloids. PO-2 132-135 renin Rattus norvegicus 112-115 16099502-4 2005 A role for O2 was based on the observation that RyR1 can be activated by submicromolar NO at physiological ( approximately 10 mmHg) but not ambient (approximately 150 mmHg) pO2. PO-2 173-176 ryanodine receptor 1 Homo sapiens 48-52 16099502-5 2005 At ambient pO2, these critical thiols were oxidized but incubation at low pO2 reset the redox state of these thiols, closed RyR1 channels and made these thiols available for nitrosation by low NO concentrations. PO-2 74-77 ryanodine receptor 1 Homo sapiens 124-128 15890701-10 2005 Among them, a group of ion channels show specific regulation in CB: the potassium channels Kir6.1 and Kcnn4 are up-regulated, while the modulatory subunit Kcnab1 is down-regulated by low PO2 levels. PO-2 187-190 potassium voltage-gated channel, shaker-related subfamily, beta member 1 Mus musculus 155-161 16003537-9 2005 It appears that the change in PO(2), rather than the sustained exposure to a hyperoxic environment, induces the changes in the EPO concentrations and erythropoietic activity. PO-2 30-35 erythropoietin Homo sapiens 127-130 15967517-9 2005 Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2. PO-2 115-118 hypoxia inducible factor 1 subunit alpha Homo sapiens 30-39 15967517-9 2005 Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2. PO-2 115-118 heat shock protein 90 alpha family class A member 1 Homo sapiens 65-70 15967517-9 2005 Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2. PO-2 131-134 hypoxia inducible factor 1 subunit alpha Homo sapiens 30-39 15967517-9 2005 Immunoprecipitation with anti-HIF1alpha antibody co-precipitates HSP90 in an oxygen-dependent manner, more at high pO2 than at low pO2. PO-2 131-134 heat shock protein 90 alpha family class A member 1 Homo sapiens 65-70 16148069-6 2005 ENO2 lowered pulmonary artery pressure and raised the Po2 in arterial blood but did not alter systemic vascular resistance or methemoglobin levels. PO-2 54-57 enolase 2 Homo sapiens 0-4 15901597-4 2005 Similarly, cytosolic and compartmented DAF-FM fluorescence increased in intact cells during a transition between ambient Po2 and 23 mmHg and was abolished by transfection with iNOS antisense oligonucleotides (AS-ODN). PO-2 121-124 nitric oxide synthase 2 Homo sapiens 176-180 15901597-8 2005 The controlled dissipation of deltapsi(m), absence of an overt glycolytic activation, and conservation of viability suggest that A549 cells enter a state of metabolic suppression in hypoxia, which inherently depends on the activation of iNOS as Po2 falls. PO-2 245-248 nitric oxide synthase 2 Homo sapiens 237-241 15710779-5 2005 A continuous intravenous infusion of a subpressor dose (3 ng/kg per minute) of Ang II for 3 days restored vasodilator responses to ACh and reduced PO2 in SS.13BN rats on HS diet and in SS rats on LS diet. PO-2 147-150 angiotensinogen Rattus norvegicus 79-85 15879309-6 2005 Raising the pO2 (100% O2) slowed the release of NO bioactivity from SNO-Hb (ie, prolonged the plasma half-life of the SNO in Hb), preserved tumor perfusion, and raised the blood pressure. PO-2 12-15 strawberry notch homolog 2 Homo sapiens 68-71 15879309-6 2005 Raising the pO2 (100% O2) slowed the release of NO bioactivity from SNO-Hb (ie, prolonged the plasma half-life of the SNO in Hb), preserved tumor perfusion, and raised the blood pressure. PO-2 12-15 strawberry notch homolog 2 Homo sapiens 118-121 15653764-6 2005 In conscious chronically instrumented dogs, AT1 receptor blockade with telmisartan improved the balance between coronary blood flow and myocardial oxygen consumption in the high-fat-fed dogs but not in normal control dogs, i.e., the relationship between coronary venous Po2 and myocardial oxygen consumption was shifted upward, toward normal control values. PO-2 270-273 angiotensin II receptor type 1 Canis lupus familiaris 44-47 15458948-6 2005 In normal swine, blockade of ETA (by EMD-122946) or ETA-ETB (by tezosentan) receptors resulted in an increase in coronary venous PO2, i.e., coronary vasodilation at rest, which decreased during exercise. PO-2 129-132 endothelin receptor type A Sus scrofa 29-32 15458948-6 2005 In normal swine, blockade of ETA (by EMD-122946) or ETA-ETB (by tezosentan) receptors resulted in an increase in coronary venous PO2, i.e., coronary vasodilation at rest, which decreased during exercise. PO-2 129-132 endothelin receptor type A Sus scrofa 52-55 21166153-1 2005 AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte. PO-2 127-130 protein tyrosine phosphatase, non-receptor type 13 Rattus norvegicus 38-66 21166153-1 2005 AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte. PO-2 127-130 protein tyrosine phosphatase, non-receptor type 13 Rattus norvegicus 68-71 21166153-1 2005 AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte. PO-2 127-130 protein tyrosine phosphatase, non-receptor type 6 Rattus norvegicus 73-78 21166153-1 2005 AIM: To explore the function state of protein tyrosine phosphatase (PTP) SHP-1 and CD45 under high partial pressure of oxygen (Po2) in lymphocyte. PO-2 127-130 protein tyrosine phosphatase, receptor type, C Rattus norvegicus 83-87 21166153-4 2005 RESULTS: The activity of SHP-1 was decreased after high Po2 treatment no matter what pressure-duration was, while the activity of CD45 was decreased only after high PoF that led to inhibition of lymphocyte function. PO-2 56-59 protein tyrosine phosphatase, non-receptor type 6 Rattus norvegicus 25-30 21166153-6 2005 CONCLUSION: The decrease of PTP catalytic activities might be caused by their structures modification by high Po2 induced reactive oxygen species. PO-2 110-113 protein tyrosine phosphatase, non-receptor type 13 Rattus norvegicus 28-31 21166153-7 2005 SHP-1 and CD45 might be one of the key points of action through which high PO2 exerts its effects on lymphocytes. PO-2 75-78 protein tyrosine phosphatase, non-receptor type 6 Rattus norvegicus 0-5 21166153-7 2005 SHP-1 and CD45 might be one of the key points of action through which high PO2 exerts its effects on lymphocytes. PO-2 75-78 protein tyrosine phosphatase, receptor type, C Rattus norvegicus 10-14 16594160-4 2005 The rate of decline in PO2 following occlusion yielded a calculated initial flux of oxygen out of the vessel lumen of 8.0 x 10(-7) ml O2 cm(-2) sec(-1). PO-2 23-26 secretory blood group 1 Rattus norvegicus 144-150 15134337-4 2004 In primary rat hepatocytes we could show that venous pO2 enhanced HIF-1alpha and USF-2a levels, both of which activated GK expression. PO-2 53-56 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 66-76 15707856-4 2005 This study employed an oleic acid model of acute lung injury to determine if TSC could increase arterial PO2 in that model. PO-2 105-108 solute carrier family 12 member 3 Rattus norvegicus 77-80 15623619-3 2004 RESULTS: High HIF-1alpha expression showed a weak correlation with low pO2 (r = -0.26; P = 0.030; n = 72). PO-2 71-74 hypoxia inducible factor 1 subunit alpha Homo sapiens 14-24 15726834-7 2004 CONCLUSIONS: These data suggest that transfer of the chromosomal region containing the renin gene is crucial in the recovery of ACh-induced dilation of arterioles in RGRR rats vs. SS rats, and that factors in the SS genetic background contribute to an enhanced sensitivity to elevated PO2, independent of genes on chromosome 13. PO-2 285-288 renin Rattus norvegicus 87-92 15134337-4 2004 In primary rat hepatocytes we could show that venous pO2 enhanced HIF-1alpha and USF-2a levels, both of which activated GK expression. PO-2 53-56 glucokinase Rattus norvegicus 120-122 14736638-9 2004 In hypotension, correlation in PO2 between VBG and CBG was similar but disappeared in ABG-VBG and ABG-CBG. PO-2 31-34 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 51-54 14522822-1 2004 Expression of the human tandem P domain K+ channel, hTREK1, is limited almost exclusively to the central nervous system, where ambient Po2 can be as low as 20 Torr. PO-2 135-138 potassium two pore domain channel subfamily K member 2 Homo sapiens 52-58 14736638-9 2004 In hypotension, correlation in PO2 between VBG and CBG was similar but disappeared in ABG-VBG and ABG-CBG. PO-2 31-34 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 102-105 14718755-5 2004 A negative correlation existed between cord serum CRP and umbilical artery pH and pO2. PO-2 82-85 C-reactive protein Homo sapiens 50-53 14616239-10 2003 It is concluded that HIF-1-mediated molecular adaptation to low PO2 is of importance in the regulation of renal medullary function and that ROS may target this HIF-1-mediated medullary adaptation to damage renal function. PO-2 64-67 hypoxia inducible factor 1 subunit alpha Homo sapiens 21-26 14645704-4 2003 Here, we demonstrate a significant enhancement of these measures of muscle performance at low physiological pO2 and an inhibitory influence at higher physiological pO2, which depend on endogenous nNOS. PO-2 164-167 nitric oxide synthase 1, neuronal Mus musculus 196-200 14645704-6 2003 In addition, responsivity to pO2 is altered significantly in nNOS mutant muscle. PO-2 29-32 nitric oxide synthase 1, neuronal Mus musculus 61-65 14643931-2 2003 Decrease of pO2 to 15-30 mm Hg induced a potentiation of HVA Ca2+ currents by 94%. PO-2 12-15 carbonic anhydrase 2 Rattus norvegicus 61-64 14554247-6 2003 Furthermore, we provide evidence of the overexpression of both CSF-1 receptor protein and mRNA by mouse monocyte-derived macrophages generated from bone marrow under low PO2. PO-2 170-173 colony stimulating factor 1 (macrophage) Mus musculus 63-68 14617292-3 2003 Significant advances in the understanding of cutaneous wound healing progressed with advances in the measurement of tissue PO2, which has advanced over the past several decades from implantable probes to now include molecular tools such as the transcription factor hypoxia inducible factor-1 (HIF-1). PO-2 123-126 hypoxia inducible factor 1 subunit alpha Homo sapiens 265-291 14617292-3 2003 Significant advances in the understanding of cutaneous wound healing progressed with advances in the measurement of tissue PO2, which has advanced over the past several decades from implantable probes to now include molecular tools such as the transcription factor hypoxia inducible factor-1 (HIF-1). PO-2 123-126 hypoxia inducible factor 1 subunit alpha Homo sapiens 293-298 12773982-14 2003 CONCLUSION: Our data suggest synergy between increased pO(2) and lipopolysaccharide for macrophage TNF and interleukin-6 production. PO-2 55-60 tumor necrosis factor Mus musculus 99-102 12925481-5 2003 The PT7+ contains three optical sensors to measure PO(2), PCO(2) and pH, as well as a thermocouple to measure temperature. PO-2 51-56 zinc finger protein 79 Homo sapiens 4-7 12682080-8 2003 These data suggest that (1) restitution of normal renin control mechanisms by chromosomal transfer contributes to the recovery of dilator responses in SS.BN13 rats versus Dahl S rats but does not affect constrictor responses to oxygen, and (2) factors in the Dahl S genetic background contribute to an enhanced sensitivity of arterioles to elevated PO2 independent of elevated blood pressure. PO-2 349-352 renin Rattus norvegicus 50-55 12773982-14 2003 CONCLUSION: Our data suggest synergy between increased pO(2) and lipopolysaccharide for macrophage TNF and interleukin-6 production. PO-2 55-60 interleukin 6 Mus musculus 107-120 12472784-12 2003 CONCLUSIONS: The reduced pO2 in outer and inner cortex, and inefficient utilization of O2 for Na+ transport in the SHR kidney can be ascribed to the effects of AT1-R, largely independent of blood pressure. PO-2 25-28 angiotensin II receptor, type 1a Rattus norvegicus 160-165 14713116-2 2003 Increased erythropoietin plasma levels and the consequent augmented production of red blood cells is the best known systemic adaptation to reduced oxygen partial pressure (pO2). PO-2 172-175 erythropoietin Homo sapiens 10-24 12509428-10 2003 Our results suggest that the effect of pO(2) on RyR1 S-nitrosylation is exerted through an allosteric mechanism. PO-2 39-44 ryanodine receptor 1 Homo sapiens 48-52 12631011-10 2003 CONCLUSION: In the normal rat, activation of ET-A receptors is partly involved in the depression of outer medullary pO2 caused by injection of iopromide. PO-2 116-119 endothelin receptor type A Rattus norvegicus 45-49 12631011-12 2003 The beneficial effects of the ET-A receptor antagonist on CM-induced changes in outer medullary pO2 seem therefore not primarily mediated on the hemodynamic level but may rather involve tubular transport mechanisms. PO-2 96-99 endothelin receptor type A Rattus norvegicus 30-34 12845221-14 2003 CONCLUSIONS: These studies indicate that blockade of AII raises pO(2 )in the interstitial microvascular compartment of the normal rat kidney. PO-2 64-70 angiotensinogen Rattus norvegicus 53-56 12537312-1 2002 A study was conducted during the first week of life to determine the changes in P50 (PO2 required to achieve a saturation of 50% at pH 7.4 and 37 degrees C) and the proportions of fetal hemoglobin (HbF) and adult hemoglobin (HbA) prior to and after transfusion in very early preterm infants. PO-2 85-88 nuclear factor kappa B subunit 1 Homo sapiens 80-83 12508771-11 2002 CONCLUSION: These data demonstrate that decreases in intra-articular pO2 occur in established arthritic conditions and may be the stimulus for local VEGF production. PO-2 69-72 vascular endothelial growth factor A Mus musculus 149-153 12456489-3 2002 Cerebral blood flow responses in these genetically altered mice to changes in PO2 demonstrate that SOD3 regulates equilibrium between superoxide (*O2-) and NO*, thereby controlling vascular tone and reactivity in the brain. PO-2 78-81 superoxide dismutase 3, extracellular Mus musculus 99-103 11706056-6 2001 FAK and paxillin expression dramatically decreased after 10 to 12 weeks of gestation coincident with increasing pO(2) levels. PO-2 112-117 protein tyrosine kinase 2 Homo sapiens 0-3 12213585-5 2002 In primary rat hepatocyte cultures, the expression of the glucagon receptor and the L-PK mRNA was maximally induced by glucose under arterial pO2 whereas the insulin receptor was maximally induced under perivenous pO2. PO-2 142-145 glucagon receptor Rattus norvegicus 58-75 12213585-5 2002 In primary rat hepatocyte cultures, the expression of the glucagon receptor and the L-PK mRNA was maximally induced by glucose under arterial pO2 whereas the insulin receptor was maximally induced under perivenous pO2. PO-2 142-145 pyruvate kinase L/R Rattus norvegicus 84-88 12213585-5 2002 In primary rat hepatocyte cultures, the expression of the glucagon receptor and the L-PK mRNA was maximally induced by glucose under arterial pO2 whereas the insulin receptor was maximally induced under perivenous pO2. PO-2 214-217 glucagon receptor Rattus norvegicus 58-75 12213585-5 2002 In primary rat hepatocyte cultures, the expression of the glucagon receptor and the L-PK mRNA was maximally induced by glucose under arterial pO2 whereas the insulin receptor was maximally induced under perivenous pO2. PO-2 214-217 pyruvate kinase L/R Rattus norvegicus 84-88 12213585-5 2002 In primary rat hepatocyte cultures, the expression of the glucagon receptor and the L-PK mRNA was maximally induced by glucose under arterial pO2 whereas the insulin receptor was maximally induced under perivenous pO2. PO-2 214-217 insulin receptor Rattus norvegicus 158-174 12213585-7 2002 The reduction of the glucose-dependent induction of the L-PK gene expression under venous pO2 appeared to be mediated via an interference between hypoxia-inducible factor 1 (HIF-1) and the glucose-responsive transcription factors at the Glc(PK)RE. PO-2 90-93 pyruvate kinase L/R Rattus norvegicus 56-60 11950391-3 2002 Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. PO-2 7-10 hepatocyte nuclear factor 4, alpha Rattus norvegicus 20-25 11950391-3 2002 Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. PO-2 7-10 hepatocyte nuclear factor 4, alpha Rattus norvegicus 37-42 11950391-3 2002 Venous pO2 enhanced HNF-4 levels and HNF-4 binding to the GK-HNF-4 element. PO-2 7-10 hepatocyte nuclear factor 4, alpha Rattus norvegicus 37-42 12003789-5 2002 In cardiomyocytes, phosphorylation of p38 was observed in a PO(2)-dependent manner during hypoxia. PO-2 60-65 mitogen-activated protein kinase 14 Homo sapiens 38-41 11731002-8 2001 CA-4 reduced the pO(2) from 36.1 to 17.6 mmHg (P=0.01) in the tumor base, and tumor hypoxia increased slightly in the tumor center (pimonidazole staining). PO-2 17-22 carbonic anhydrase 4 Rattus norvegicus 0-4 11592948-2 2001 By Northern blot analysis, HO-1 mRNA expression was found to significantly increase in response to reduction of PO(2) in culture medium. PO-2 112-117 heme oxygenase 1 Homo sapiens 27-31 11678630-1 2001 This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. PO-2 214-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-57 11678630-1 2001 This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. PO-2 214-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 59-64 12162728-10 2002 Thus the ratio of mRNAs encoding these antagonistic factors changes (in favour of Ang-2), in the placenta in response to a reduction in PO2. PO-2 136-139 angiopoietin 2 Homo sapiens 82-87 12022758-9 2002 In contrast to the macrohemodynamic, the decrease in tissue surface PO2 in response to ET-1 infusion was potentiated by LPS treatment (increased from baseline levels 33.8+/-9 to 46.8+/-8.3 in sham; 42.3+/-9.1 to 69+/-6.5 gray scale units in LPS; P < 0.01, sham vs. LPS) at end of infusion of ET-1 for 10 min. PO-2 68-71 endothelin 1 Rattus norvegicus 87-91 12022758-9 2002 In contrast to the macrohemodynamic, the decrease in tissue surface PO2 in response to ET-1 infusion was potentiated by LPS treatment (increased from baseline levels 33.8+/-9 to 46.8+/-8.3 in sham; 42.3+/-9.1 to 69+/-6.5 gray scale units in LPS; P < 0.01, sham vs. LPS) at end of infusion of ET-1 for 10 min. PO-2 68-71 endothelin 1 Rattus norvegicus 295-299 11884929-13 2002 After instillation of SP-A-enriched surfactant, PO2 values were reached that approximated sham control PO2 values, whereas after SP-A-deficient surfactant treatment, the PO2 values did not improve. PO-2 48-51 surfactant protein A1 Rattus norvegicus 22-26 11884929-13 2002 After instillation of SP-A-enriched surfactant, PO2 values were reached that approximated sham control PO2 values, whereas after SP-A-deficient surfactant treatment, the PO2 values did not improve. PO-2 103-106 surfactant protein A1 Rattus norvegicus 22-26 11884929-13 2002 After instillation of SP-A-enriched surfactant, PO2 values were reached that approximated sham control PO2 values, whereas after SP-A-deficient surfactant treatment, the PO2 values did not improve. PO-2 103-106 surfactant protein A1 Rattus norvegicus 22-26 11706056-6 2001 FAK and paxillin expression dramatically decreased after 10 to 12 weeks of gestation coincident with increasing pO(2) levels. PO-2 112-117 paxillin Homo sapiens 8-16 11396794-2 2001 Mediated by the hypoxia-inducible transcription factor HIF-1alpha/beta, a reduction in O2 tension (pO2) leads to increased VEGF gene expression in nonmalignant tissues. PO-2 99-102 hypoxia inducible factor 1 subunit alpha Homo sapiens 55-65 11606368-8 2001 Spatial distribution analysis of EF5 and HIF-1alpha is consistent with different pO2 value "thresholds" for EF5 binding and HIF-1alpha expression. PO-2 81-84 angiogenin, ribonuclease A family, member 3 Mus musculus 33-36 11606368-8 2001 Spatial distribution analysis of EF5 and HIF-1alpha is consistent with different pO2 value "thresholds" for EF5 binding and HIF-1alpha expression. PO-2 81-84 hypoxia inducible factor 1, alpha subunit Mus musculus 41-51 11606368-8 2001 Spatial distribution analysis of EF5 and HIF-1alpha is consistent with different pO2 value "thresholds" for EF5 binding and HIF-1alpha expression. PO-2 81-84 angiogenin, ribonuclease A family, member 3 Mus musculus 108-111 11524238-9 2001 In addition, IGFBP-1 levels were inversely correlated with PO(2) values (r=-0.39 in UA and r=-0.34 in UV; P<0.001); quartiles of UA and UV PO2 showed a gradual increase in IGFBP-1 concentrations with lower PO2 values. PO-2 142-145 insulin like growth factor binding protein 1 Homo sapiens 13-20 11524238-9 2001 In addition, IGFBP-1 levels were inversely correlated with PO(2) values (r=-0.39 in UA and r=-0.34 in UV; P<0.001); quartiles of UA and UV PO2 showed a gradual increase in IGFBP-1 concentrations with lower PO2 values. PO-2 209-212 insulin like growth factor binding protein 1 Homo sapiens 13-20 11524238-12 2001 The data of this study indicate that serum IGFBP-1 levels in term fetuses are determined by both insulin and PO2 levels, and suggest that acute hypoxemia stimulates IGFBP-1 secretion in the fetus. PO-2 109-112 insulin like growth factor binding protein 1 Homo sapiens 43-50 11719175-6 2001 RESULTS: In adult PMN, L-selectin downregulation was greatly accelerated by hypoxia (PO2=27.2+/-3.4 mmHg) compared with both normoxia (PO2=71.0+/-11.0 mmHg) or hyperoxia (PO2=653.2+/-9.4) (P<0.05). PO-2 85-88 selectin L Homo sapiens 23-33 11719175-6 2001 RESULTS: In adult PMN, L-selectin downregulation was greatly accelerated by hypoxia (PO2=27.2+/-3.4 mmHg) compared with both normoxia (PO2=71.0+/-11.0 mmHg) or hyperoxia (PO2=653.2+/-9.4) (P<0.05). PO-2 135-138 selectin L Homo sapiens 23-33 11299203-2 2001 Under basal normoxic conditions, the cellular PO2 is sufficient to saturate myoglobin (Mb). PO-2 46-49 myoglobin Rattus norvegicus 76-85 11396794-2 2001 Mediated by the hypoxia-inducible transcription factor HIF-1alpha/beta, a reduction in O2 tension (pO2) leads to increased VEGF gene expression in nonmalignant tissues. PO-2 99-102 vascular endothelial growth factor A Homo sapiens 123-127 11309343-10 2001 By using a low-tech scoring system, pO(2) was found to correlate weakly with Glut-1 score (r = 0.28; P = 0.04). PO-2 36-41 solute carrier family 2 member 1 Homo sapiens 77-83 11518466-7 2001 Using EF5, a fluorinated 2-nitroimidazole which localizes to hypoxic cells, MCF-7-5C tumors grown in nude mice were found to contain lower pO2 levels and more hypoxic regions than similarly grown MCF-7 tumors. PO-2 139-142 angiogenin, ribonuclease A family, member 3 Mus musculus 6-9 11330538-10 2001 During this period there was an increasing negative correlation between peak-CRP and tissue pO2 which was highly significant at 60 min after reperfusion (r=-0.70, P<0.002). PO-2 92-95 C-reactive protein Homo sapiens 77-80 11950148-1 2001 The purpose of this article is to set out the hypothesis that arterial PO2 may play a significant role in the regulation of breathing at sea level. PO-2 71-74 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 137-140 11950137-2 2001 EPO has been the fountainhead in research on pO2-dependent synthesis of proteins. PO-2 45-48 erythropoietin Homo sapiens 0-3 11950148-3 2001 2) Although the ventilatory response to an acute variation in alveolar PO2 around sea-level values is feeble, studies at altitude have shown that over longer-time periods alveolar PO2 is a more powerful regulator of ventilation. PO-2 71-74 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 82-85 11950148-4 2001 3) Recent evidence suggests that mechanisms associated with ventilatory acclimatization to hypoxia are active at sea-level values for PO2, and indeed affect the acute ventilatory response to hypoxia. PO-2 134-137 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 113-116 11123247-14 2001 Reductions of HEP and PO(2) were also highly correlated (although nonlinearly); with the assumption that myoglobin was 90% saturated with O(2) during basal conditions and 5% saturated during total coronary occlusion, the intracellular PO(2) values for 20% reductions of PCr and ATP were approximately 4. PO-2 22-27 myoglobin Canis lupus familiaris 105-114 11123247-14 2001 Reductions of HEP and PO(2) were also highly correlated (although nonlinearly); with the assumption that myoglobin was 90% saturated with O(2) during basal conditions and 5% saturated during total coronary occlusion, the intracellular PO(2) values for 20% reductions of PCr and ATP were approximately 4. PO-2 235-240 myoglobin Canis lupus familiaris 105-114 11071299-9 2000 Cytochrome P450 4A blockers also attenuate the vasoconstrictor response to elevations in tissue PO2, suggesting that this system may serve as a vascular oxygen sensor. PO-2 96-99 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 11509826-1 2001 In excitatory cells specific responses upon changes in PO(2) are mediated by changes in intracellular Ca (Ca(i)). PO-2 55-60 carbonic anhydrase 1 Rattus norvegicus 106-111 11122151-8 2000 Similar results were observed in cultures initiated with CD41(+) Mks, indicating that pO(2) directly affects Mks. PO-2 86-91 integrin subunit alpha 2b Homo sapiens 57-61 11115069-8 2000 Transient transfections identified a hypoxia response element (HRE) in the TIMP-1 promoter and demonstrated HIF-1-dependent promoter activation by decreased ambient pO2. PO-2 165-168 hypoxia inducible factor 1 subunit alpha Homo sapiens 108-113 10966111-3 2000 Here we report that PO2 dynamically controls the redox state of 6-8 out of 50 thiols in each RyR1 subunit and thereby tunes the response to NO. PO-2 20-23 ryanodine receptor 1 Homo sapiens 93-97 11001829-12 2000 Although HIF-1 and NFkappaB respond to changes in pO(2), the precise nature of the oxygen sensing and transduction pathways is unclear in both cases. PO-2 50-55 hypoxia inducible factor 1 subunit alpha Homo sapiens 9-14 11001829-12 2000 Although HIF-1 and NFkappaB respond to changes in pO(2), the precise nature of the oxygen sensing and transduction pathways is unclear in both cases. PO-2 50-55 nuclear factor kappa B subunit 1 Homo sapiens 19-27 10969807-4 2000 Here we report on the dynamics of pO2 and oxygen consumption in a hormone-dependent tumor following hormone ablation and during treatment with an anti-VEGFR-2 monoclonal antibody (mAb) or a combination of doxorubicin and cyclophosphamide; the latter combination is not known to cause vessel regression at doses used clinically. PO-2 34-37 kinase insert domain protein receptor Mus musculus 151-158 10947166-10 2000 The IL-1beta group also showed greater PO2 and plasma lactate levels in the portal vein than did the control group. PO-2 39-42 interleukin-1 beta Oryctolagus cuniculus 4-12 10662897-9 2000 There was, however, a positive correlation between arterial PO2 and renal renin mRNA (r2 = 0.77, P < 0.01). PO-2 60-63 renin Ovis aries 74-79 10746842-4 2000 RESULTS: A novel finding was that ET-1 correlated to PO2 in amniotic fluid. PO-2 53-56 endothelin 1 Homo sapiens 34-38 10746842-9 2000 High EPO values, similarly to ET-1, correlated to low pO2 values. PO-2 54-57 erythropoietin Homo sapiens 5-8 10746842-9 2000 High EPO values, similarly to ET-1, correlated to low pO2 values. PO-2 54-57 endothelin 1 Homo sapiens 30-34 10746842-11 2000 CONCLUSIONS: The results indicate that ET-1 levels may be a marker for short-term hypoxia, but not for fetal growth, since ET-1 in amniotic fluid was correlated to PO2 at the time of cordocentesis, but not to birth weight. PO-2 164-167 endothelin 1 Homo sapiens 39-43 10793443-10 2000 Ascent to 4,000 m above sea level induced a significant decrease in arterial pO2 (10.7 +/- 1.1 vs 5.5 +/- 0.3 kPa), pCO2 (5.3 +/- 0.3 vs 4.7 +/- 0.4 kPa), oxygen saturation measured by arterial blood gas analysis (95.5% +/- 1.2% vs 79.1% +/- 2.5%), and increase in pH (7.39 +/- 0.02 vs 7.45 +/- 0.04) (P < 0.0001). PO-2 77-80 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 24-27 10766932-4 2000 Higher PO2 was associated with increased short circuit current (ISC) and increased abundance of the Na+ channel protein alpha-ENaC. PO-2 7-10 sodium channel epithelial 1 subunit alpha Rattus norvegicus 120-130 10763960-10 2000 In patients with positive KDR in the tumor, the arterial levels of PO2 and O2 saturation were significantly lower than those in patients without its expression. PO-2 67-70 kinase insert domain receptor Homo sapiens 26-29 10765515-13 2000 This increase of the AADC activity is associated with reduced brain tissue pO2. PO-2 75-78 dopa decarboxylase Homo sapiens 21-25 10401602-3 1999 The degree to which the decrease in pH and the freeing of copper ions, as well as the variations in pO2 associated with ischemia and reperfusion increase the rates of such myoglobin reactions has been investigated. PO-2 100-103 myoglobin Homo sapiens 172-181 10626068-12 1999 In ET-1+/- mice, PCO2 tended to be higher and PO2 was significantly lower than corresponding values in ET-1+/+ mice. PO-2 46-49 endothelin 1 Mus musculus 3-7 10385683-6 1999 Within 3 days, phenobarbital induced CYP2B1 mRNA to maximal levels under arterial pO2 and to about 40% of maximal levels under venous pO2. PO-2 82-85 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 37-43 10385683-6 1999 Within 3 days, phenobarbital induced CYP2B1 mRNA to maximal levels under arterial pO2 and to about 40% of maximal levels under venous pO2. PO-2 134-137 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 37-43 10494674-5 1999 CCB+TRH reduced the concentrations of serum urea and creatinine, the degree of pancreatic damage, and increased PO2 and serum calcium concentration. PO-2 112-115 thyrotropin releasing hormone Rattus norvegicus 4-7 9761743-1 1998 H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene. PO-2 39-42 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 111-144 10352037-6 1999 Upon association with Kvbeta1.2, Kv4.2 can be modified by DTT (1,4 dithiothreitol) and DTDP (2,2"-dithiodipyridine), which also modulate the low pO2 response of the Kv4.2+beta channels. PO-2 145-148 potassium voltage-gated channel subfamily D member 2 Homo sapiens 33-38 10329878-8 1999 RESULTS: Baseline PO2 before hypoxemia was significantly lower and oxygen content was significantly higher in fetuses in the long-term oxytocin group than in control fetuses. PO-2 18-21 oxytocin/neurophysin I prepropeptide Homo sapiens 135-143 10030263-15 1999 In a multivariate analysis, both the effect of radiation dose (pretreatment versus 19.8 Gy) and the type of treatment (XRT alone versus XRT plus cRA/IFN) had significant impact on the pO2 (P = 0.003 and p = 0.04). PO-2 184-187 interferon alpha 1 Homo sapiens 149-152 9761743-1 1998 H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene. PO-2 39-42 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 146-149 9761743-1 1998 H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene. PO-2 39-42 glucokinase Rattus norvegicus 200-211 9761743-1 1998 H2O2 mimicked the action of periportal pO2 in the modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase (PCK) gene and the insulin-dependent activation of the glucokinase (GK) gene. PO-2 39-42 glucokinase Rattus norvegicus 213-215 9761743-6 1998 PCK mRNA was induced by glucagon maximally under conditions of periportal pO2 and half-maximally under venous pO2. PO-2 74-77 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 0-3 9761743-6 1998 PCK mRNA was induced by glucagon maximally under conditions of periportal pO2 and half-maximally under venous pO2. PO-2 110-113 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 0-3 9688918-5 1998 From the measured SMb, we assessed the profile of radial changes in intracellular PO2 at the mean SMb comparable to that in vivo ( approximately 0.5). PO-2 82-85 small nuclear ribonucleoprotein polypeptides B and B1 Rattus norvegicus 98-101 9742944-2 1998 In the normoxic resting state, the blood and tissue pO2 is sufficient to saturate both Mb and Hb. PO-2 52-55 myoglobin Rattus norvegicus 87-89 9603116-7 1998 Further, the activity of COX was inversely related to arterial PO2 value (Rho -0.59, p < 0.01). PO-2 63-66 coproporphyrinogen oxidase Homo sapiens 25-28 9554954-7 1998 Hypoxia (PO2 = 5 mm Hg) caused three to five times greater increases in [Ca2+]i in PND 18-22 slices than in PND 3-7 slices (p < 0.001). PO-2 9-12 carbonic anhydrase 2 Rattus norvegicus 73-76 9575899-10 1998 Hb-P11 may also have shunted O2 from the outer cortex to the outer medulla and facilitated O2 diffusion where PO2 was low. PO-2 110-113 S100 calcium binding protein A10 Rattus norvegicus 3-6 9496893-3 1998 The median pO2 in control SCK tumors was 4.4 +/- 0.2 mm Hg, and it increased to a maximum of 12.6 +/- 1.2 mm Hg when the tumors were heated at 41.5 degrees C for 1 h. Carbogen breathing increased the median pO2 of SCK tumors to 17.1 +/- 1.4 mm Hg, but after heating at 41.5 degrees C, it elevated the pO2 in SCK tumors markedly to 31.3 +/- 4.2 mm Hg. PO-2 11-14 SHC (Src homology 2 domain containing) transforming protein 2 Mus musculus 26-29 9453490-7 1998 All 21 patients with positive MAA scans had PO2 values of <60 mm Hg. PO-2 44-47 MAA Homo sapiens 30-33 9635158-5 1998 Bradykinin (0.1-100 nM) dose dependently (from 1-3 nM upwards) relaxed endothelium-denuded arteries that had been precontracted with a thromboxane (TX) A2 analog (ONO-11113, 0.1 microM) or excess potassium (5 mM Ca2+ in K(+)-Krebs) at a neonatal Po2. PO-2 246-249 kininogen 1 Homo sapiens 0-10 9595536-1 1998 Endothelin-1 (ET-1) is produced by some tumor cells, but the dependence of this production on pO2 and pCO2, conditions relevant within the tumor microenvironment, has not been described. PO-2 94-97 endothelin 1 Homo sapiens 0-12 9453315-4 1998 Intravenous infusion of Ang II at the same dose in the presence of L-NAME decreased MBF by 23% and medullary PO2 by 28%, but it had no effect on cortical blood flow or arterial blood pressure. PO-2 109-112 angiotensinogen Rattus norvegicus 24-30 9769930-1 1998 We have shown that administration of inorganic potassium phosphates (Pi) to patients with severe diabetic ketoacidosis was able to increase the P50 (the PO2 necessary to achieve a hemoglobin saturation of 50%) by a non diphosphoglycerate (DPG) mediated effect. PO-2 153-156 nuclear factor kappa B subunit 1 Homo sapiens 144-147 9232684-5 1997 The mean peripheral-chemoreflex sensitivity of 11.5 (5.2) L min-1 mmHg-1 at an iso-oxic PO2 of 40 was significantly greater than 3.0 (1.3), 2.7 (1.2) and 2.4 (1.2) at 60, 80 and 100, respectively. PO-2 88-91 CD59 molecule (CD59 blood group) Homo sapiens 60-65 9092616-1 1997 In contrast to shorter homologs which only form a single-stranded nucleic acid alpha-helix in acid solution at [Na+]</=0.02 M Na+, d(A-G)20,30 form in addition a parallel-stranded duplex with (A+.A+) and (G.G) base pairs and interstrand dA+...PO2-ionic and dA+NH2... O=P H-bonds. PO-2 246-249 dystroglycan 1 Homo sapiens 134-139 9027711-10 1997 This demonstrates that oxygen shunt diffusion in the kidney cortex and medulla is a prerequisite for both the function of a sensor to measure pO2 and oxygen capacity to regulate erythropoietin secretion and to enable an effective adjustment of blood flow to the metabolic and functional demands of the kidney. PO-2 142-145 erythropoietin Rattus norvegicus 178-192 9108184-6 1997 Further, a negative correlation between interleukin-8 release of alveolar macrophages and the arterial pO2 at the time of BALF could be demonstrated (r = -0.47, p < 0.05). PO-2 103-106 C-X-C motif chemokine ligand 8 Homo sapiens 40-53 9003396-2 1997 GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. PO-2 75-78 glucokinase Rattus norvegicus 0-2 9269425-14 1997 We conclude that: 1) The application of EPR oximetry with LiPc provides dynamic evaluation of local myocardial pO2 in the contracting heart. PO-2 111-114 lipase C, hepatic type Rattus norvegicus 58-62 9027735-0 1997 Diminution of the O2 responsiveness of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocytes by long-term culture at venous PO2. PO-2 169-172 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 80-113 9003396-2 1997 GK mRNA was induced by insulin maximally under venous O2 partial pressure (pO2) and only half-maximally under arterial pO2. PO-2 119-122 glucokinase Rattus norvegicus 0-2 9003396-3 1997 CoCl2 and desferrioxamine mimicked venous pO2 and enhanced the insulin-dependent induction of GK mRNA under arterial pO2. PO-2 117-120 glucokinase Rattus norvegicus 94-96 9003396-4 1997 H2O2 mimicked arterial pO2 and reduced insulin-induced GK mRNA under venous pO2 to the lower arterial levels. PO-2 76-79 glucokinase Rattus norvegicus 55-57 9029202-6 1997 The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)]. PO-2 4-7 myoglobin Equus caballus 17-26 9029202-6 1997 The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)]. PO-2 4-7 myoglobin Equus caballus 122-131 9029202-6 1997 The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)]. PO-2 199-202 myoglobin Equus caballus 17-26 9029202-6 1997 The PO2 at which myoglobin is half-saturated with O2 (P50) was determined to be 2.39 Torr at pH 7.0 and 37 degrees C. The myoglobin dissociation curve was well fit by the Hill equation [saturation = PO2/(PO2 + P50)]. PO-2 199-202 myoglobin Equus caballus 122-131 8763588-3 1996 In COLD patients HbCO induces a left shift of the ODC according to the following equation: P50 (Torr) = 27.6-0.4 (HbCO-1) where P50 is the PO2 necessary to saturate hemoglobin at 50%. PO-2 139-142 nuclear factor kappa B subunit 1 Homo sapiens 91-94 8997205-6 1996 The presence of myoglobin maintains the PO2 in the fiber core above anoxic levels for the majority of muscles. PO-2 40-43 myoglobin Equus caballus 16-25 8997205-7 1996 Thus myoglobin is critical to O2 supply at fluxes near the maximum and prevents anoxia by maintaining PO2 above levels needed to support mitochondrial function. PO-2 102-105 myoglobin Equus caballus 5-14 8878445-7 1996 We have found that exposure of cultured human aortic smooth muscle cells and mononuclear phagocytes (MPs) to hypoxia (pO2 approximately 12-14 torr) induces ORP150 transcripts and production of the antigen, whereas incubation with either hydrogen peroxide, sodium arsenite, heat shock, or 2-deoxyglucose was without effect. PO-2 118-121 hypoxia up-regulated 1 Homo sapiens 156-162 9080248-6 1996 Supernatant gamma-IFN, IL-2, and IL-4 concentrations were elevated 50-65% when PBMC were stimulated with Con A for 24 h under low pO2; however, lipopolysaccharide (LPS)-stimulated IL-1 beta production was reduced by over 75%. PO-2 130-133 interleukin 4 Homo sapiens 33-37 9080248-8 1996 Immunophenotyping analyses did not reveal any significant alterations in cell subset or marker distribution at the time points examined; however, an interesting trend of increased CD69 expression was observed for Con A-stimulated PBMC incubated under low pO2. PO-2 255-258 CD69 molecule Homo sapiens 180-184 8829123-3 1996 Myoglobin infusion (3.3 mg/min) reduced outer medullary blood flow and Po2, whereas renal blood flow and cortical Po2 were unaffected. PO-2 71-74 myoglobin Rattus norvegicus 0-9 8724724-3 1996 Significant inverse correlations were found between Ua EPO levels and pO2 (r = -0.44, p < 0.002), pH (r = -0.68, p < 0.0001), as well as base deficit (r = -0.56, p < 0.0001). PO-2 70-73 erythropoietin Homo sapiens 55-58 8619027-0 1996 Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry. PO-2 30-33 RIKEN cDNA 4932438A13 gene Mus musculus 77-80 8619027-1 1996 We have used very low-frequency electron paramagnetic resonance (EPR) oximetry to measure the change in oxygen concentration (delta pO2) due to change in breathing atmosphere in FSa and NFSa fibrosarcomas implanted in the legs of C3H mice infused with perfluoro-octylbromine (PFOB). PO-2 132-135 RIKEN cDNA 4932438A13 gene Mus musculus 178-181 8842392-5 1996 The hypoxic insult (cortical pO2 = 3-10 mmHg) induced expression of hsp72 mRNA in regions of both white and gray matter, with strong expression occurring in the cerebral cortex of individual animals. PO-2 29-32 heat shock protein family A (Hsp70) member 1A Homo sapiens 68-73 8655601-3 1996 Endothelial cells sense pO2 levels in the range of 70-20 torr and respond to this hypoxia by inducing transcription of genes which encode the vasoactive proteins PDGF-B and endothelin-1. PO-2 24-27 platelet derived growth factor subunit B Homo sapiens 162-168 8655601-3 1996 Endothelial cells sense pO2 levels in the range of 70-20 torr and respond to this hypoxia by inducing transcription of genes which encode the vasoactive proteins PDGF-B and endothelin-1. PO-2 24-27 endothelin 1 Homo sapiens 173-185 8606506-1 1996 The purpose of these studies was to examine the sensitivity of the PIP 2-PLC-transducing pathway (GPLC) and its relationship to the respiratory burst in human polymorphonuclear leukocytes (PMN) stimulated by IL-8, TNF-alpha, or IL-1 beta during sequential changes in buffer oxygen tension from normoxia (pO2 = 180-200 mm Hg), to hypoxia (pO2 < 30 mm Hg) and then reoxygenation (pO2 > 140 mm Hg). PO-2 304-307 prolactin induced protein Homo sapiens 67-70 8606506-1 1996 The purpose of these studies was to examine the sensitivity of the PIP 2-PLC-transducing pathway (GPLC) and its relationship to the respiratory burst in human polymorphonuclear leukocytes (PMN) stimulated by IL-8, TNF-alpha, or IL-1 beta during sequential changes in buffer oxygen tension from normoxia (pO2 = 180-200 mm Hg), to hypoxia (pO2 < 30 mm Hg) and then reoxygenation (pO2 > 140 mm Hg). PO-2 338-341 prolactin induced protein Homo sapiens 67-70 8606506-1 1996 The purpose of these studies was to examine the sensitivity of the PIP 2-PLC-transducing pathway (GPLC) and its relationship to the respiratory burst in human polymorphonuclear leukocytes (PMN) stimulated by IL-8, TNF-alpha, or IL-1 beta during sequential changes in buffer oxygen tension from normoxia (pO2 = 180-200 mm Hg), to hypoxia (pO2 < 30 mm Hg) and then reoxygenation (pO2 > 140 mm Hg). PO-2 338-341 prolactin induced protein Homo sapiens 67-70 8763588-3 1996 In COLD patients HbCO induces a left shift of the ODC according to the following equation: P50 (Torr) = 27.6-0.4 (HbCO-1) where P50 is the PO2 necessary to saturate hemoglobin at 50%. PO-2 139-142 nuclear factor kappa B subunit 1 Homo sapiens 128-131 8929607-6 1996 The contribution of Hb, P50, and PO2 changes to the increments of a-vCO2 difference during exercise was 21, 17, and 63%, respectively; the only interclass difference observed was for P50, which plays a greater role in a-vCO2 difference in class A. Hb changes act mainly at the arterial site, whereas P50 and PO2 act at the venous site. PO-2 33-36 nuclear factor kappa B subunit 1 Homo sapiens 183-186 8929607-6 1996 The contribution of Hb, P50, and PO2 changes to the increments of a-vCO2 difference during exercise was 21, 17, and 63%, respectively; the only interclass difference observed was for P50, which plays a greater role in a-vCO2 difference in class A. Hb changes act mainly at the arterial site, whereas P50 and PO2 act at the venous site. PO-2 33-36 nuclear factor kappa B subunit 1 Homo sapiens 183-186 8524017-0 1995 The apparent diffusion constant measured by MRI correlates with pO2 in a RIF-1 tumor. PO-2 64-67 replication timing regulatory factor 1 Mus musculus 73-78 8537049-2 1995 By using deoxified saline and measuring PO2 as well as PCO2 this study aimed to follow changes in mucosal PO2 and relate them to changes in pHi in peritonitis versus haemorrhage. PO-2 106-109 PCO2 Sus scrofa 55-59 8537049-5 1995 The drop in pHi correlated well with decreasing intraluminal PO2 (r = 0.63 (0.13)) in haemorrhage. PO-2 61-64 vasoactive intestinal peptide Sus scrofa 12-15 8825876-12 1995 We conclude that the application of EPR oximetry with LiPc to the isolated heart provides accurate and dynamic evaluation of local myocardial PO2 in the contracting heart. PO-2 142-145 lipase C, hepatic type Rattus norvegicus 54-58 8593588-6 1995 Significant induction of c-fos mRNA was seen with hypoxic exposure as short as 15 min and the effects persisted at 10 h of low pO2 exposure. PO-2 127-130 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 25-30 8547550-11 1995 Venous ET-1 levels were significantly correlated with venous oxygen content, pH, PO2, oxygen saturation, base excess, blood sodium concentration, and potassium concentration. PO-2 81-84 endothelin 1 Homo sapiens 7-11 7649925-6 1995 For a decrease of PO2 from 132 Torr to 14 Torr, the change in pHi values, on average, for cat and rat glomus cells was 0.034 lower, and with PO2 decrease to 1-2 Torr for the cat glomus cells, the change in pHi values was 0.051 lower. PO-2 18-21 glucose-6-phosphate isomerase Rattus norvegicus 62-65 7626597-0 1995 Gating of thrombin in platelet aggregates by pO2-linked lowering of extracellular Ca2+ concentration. PO-2 45-48 coagulation factor II, thrombin Homo sapiens 10-18 7556471-6 1995 From fitting PO2 profiles measured in the dark-adapted retina to a three-layer diffusion model, O2 consumption was found to be 1.0 +/- 0.4 and 0.4 +/- 0.3 ml O2 (100 g min)-1 in the outer and inner halves of the retina, respectively. PO-2 13-16 immunoglobulin kappa variable 1D-39 Homo sapiens 158-174 7757972-3 1995 Initial values of pO2 in RIF-1 (8.7 +/- 1.1 mm Hg; n = 14) were higher than that of pO2 in MTG-B (3.3 +/- 0.5 mm Hg; n = 19). PO-2 18-21 replication timing regulatory factor 1 Mus musculus 25-30 7757972-6 1995 After a 20-Gy radiation dose, the pO2 was 2.2 +/- 0.5 mm Hg at 6 h [significantly lower (P < 0.0001) than in control] and 3.2 +/- 0.5 mm Hg at 48 h [significantly higher (P < 0.02) than in control] in MTG-B, and 5.4 +/- 1.2 mm Hg at 24 h and 8.2 +/- 1.0 mm Hg at 72 h in RIF-1. PO-2 34-37 replication timing regulatory factor 1 Mus musculus 277-282 8534326-4 1995 Hypoxia (pO2 = 7.8%) was shown to alter studied parameters (AChE, AC, Na+, K(+)-ATPase activity, and PL content) mainly in the right hemisphere. PO-2 9-12 acetylcholinesterase Rattus norvegicus 60-64 7649925-6 1995 For a decrease of PO2 from 132 Torr to 14 Torr, the change in pHi values, on average, for cat and rat glomus cells was 0.034 lower, and with PO2 decrease to 1-2 Torr for the cat glomus cells, the change in pHi values was 0.051 lower. PO-2 18-21 glucose-6-phosphate isomerase Rattus norvegicus 206-209 7649925-8 1995 Thus glomus cell pHi change due to low PO2 exposure was not significant and was not commensurate with the large increases in the chemosensory activity. PO-2 39-42 glucose-6-phosphate isomerase Rattus norvegicus 17-20 7805238-8 1995 Plasma endothelin-1 was increased twofold at high altitude (5.9 +/- 2.2 pg/mL compared with 2.9 +/- 1.1 pg/mL, P < .05), was inversely related to arterial PO2 (r = -.46, P < .001), and correlated with pulmonary artery pressure (r = .52, P < .002). PO-2 158-161 endothelin 1 Homo sapiens 7-19 7752579-9 1995 At the end of the experiment, elevated plasma renin activity and pCO2, significantly decreased creatinine clearance, blood pH, pO2, base excess, HCO3-, oxygen saturation (P < 0.01), a distinct glomerular proteinuria, and a final anuria were observated. PO-2 127-130 PCO2 Sus scrofa 65-69 7864128-1 1995 We tested the hypothesis that reducing the hepatic O2 supply by 30 min of constant-flow hypoxia (PO2, approximately 45 Torr) following gram-negative bacteremia downregulates tumor necrosis factor-alpha (TNF-alpha) in buffer-perfused rat lives (total n = 44). PO-2 97-100 tumor necrosis factor Rattus norvegicus 174-201 7864128-1 1995 We tested the hypothesis that reducing the hepatic O2 supply by 30 min of constant-flow hypoxia (PO2, approximately 45 Torr) following gram-negative bacteremia downregulates tumor necrosis factor-alpha (TNF-alpha) in buffer-perfused rat lives (total n = 44). PO-2 97-100 tumor necrosis factor Rattus norvegicus 203-212 7882182-3 1994 (i) 5-Hydroxytryptamine (5-HT) and endothelin-1 (ET-1) contracted the HUA at either low or high PO2. PO-2 96-99 endothelin 1 Homo sapiens 35-47 8552862-5 1995 Serum CEA values significantly correlated to serum lactate dehydrogenase activity and alveolar-arterial PO2 difference values in patients with PAP. PO-2 104-107 CEA cell adhesion molecule 3 Homo sapiens 6-9 7526714-5 1994 Exposing human endothelial cells to low PO2 results in 40-60% reduction in the steady-state mRNA levels of endothelial constitutive NO synthase (eNOS), the major enzyme responsible for NO production in these cells. PO-2 40-43 nitric oxide synthase 3 Homo sapiens 107-143 7526714-5 1994 Exposing human endothelial cells to low PO2 results in 40-60% reduction in the steady-state mRNA levels of endothelial constitutive NO synthase (eNOS), the major enzyme responsible for NO production in these cells. PO-2 40-43 nitric oxide synthase 3 Homo sapiens 145-149 7974500-2 1994 Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating factor (GM-CSF)-induced colony formation were additive. PO-2 74-77 colony stimulating factor 2 Homo sapiens 88-136 7974500-2 1994 Initial experiments indicated that the inhibitory effects of near-ambient pO2 and HQ on granulocyte/macrophage colony-stimulating factor (GM-CSF)-induced colony formation were additive. PO-2 74-77 colony stimulating factor 2 Homo sapiens 138-144 8067420-9 1994 From this fraction, the average PO2 in the environment of myoglobin was estimated under several perfusion conditions. PO-2 32-35 myoglobin Rattus norvegicus 58-67 7838685-10 1994 These results suggest that reduced PO2 increases the activity of a high-conductance, Ca(2+)-sensitive K+ channel in cat cerebral arterial muscle cells, and that these effects are mediated by cytosolic events independent of changes in [Ca2+]i and pHi. PO-2 35-38 glucose-6-phosphate isomerase Homo sapiens 246-249 7923755-9 1994 Similarly the changes in pO2 alone did not cause the release of cathepsin D, but there were marked increases in the release of cathepsin D at each pO2 in the presence of OFRs. PO-2 147-150 cathepsin D Canis lupus familiaris 127-138 8067466-9 1994 The results show that differences in egg size affect the timing of CAII and 2,3-DPG synthesis, indicating that PO2-dependent regulation of red cell function allows adjustment to the properties of the individual egg. PO-2 111-114 carbonic anhydrase 2 Gallus gallus 67-77 8013080-10 1994 Immunoblot analyses revealed that there was a 2.6-fold greater abundance of cyclooxygenase-1 protein at PO2 of 40 versus 680 mm Hg, and the increase at lower oxygen tension was inhibited by cycloheximide. PO-2 104-107 prostaglandin G/H synthase 1 Ovis aries 76-92 8163658-2 1994 Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8. PO-2 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 119-123 8163658-2 1994 Incubation of human endothelial cells (ECs) in hypoxia, PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs, blocked by antibody to IL-8. PO-2 56-59 C-X-C motif chemokine ligand 8 Homo sapiens 249-253 8163658-7 1994 In mice exposed to hypoxia (PO2 approximately 30-40 Torr), there was increased pulmonary leukostasis, as evidenced by increased myeloperoxidase activity in tissue homogenates. PO-2 28-31 myeloperoxidase Mus musculus 128-143 7872091-0 1994 Low PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body. PO-2 4-7 acetylcholinesterase Rattus norvegicus 48-68 7735958-0 1994 Changes in skeletal muscle pO2 after administration of anti-TNF alpha-antibody in patients with severe sepsis: comparison to interleukin-6 serum levels, APACHE II, and Elebute scores. PO-2 27-30 tumor necrosis factor Homo sapiens 60-69 7735958-6 1994 These data suggest that a decrease of skeletal muscle pO2 might be an early indicator of improvement of sepsis after administration of anti-TNF alpha-antibodies. PO-2 54-57 tumor necrosis factor Homo sapiens 140-149 7597990-0 1994 Computerized histographic characterization of changes in tissue pO2 induced by erythropoietin. PO-2 64-67 erythropoietin Mus musculus 79-93 8153448-5 1994 It is hypothesised that hydrogen peroxide (H2O2) produced by this cytochrome b in direct correlation with cellular PO2, serves as a second messenger to regulate potassium channels or gene expression. PO-2 115-118 mitochondrially encoded cytochrome b Homo sapiens 66-78 7597990-10 1994 These data lend support to the value of EPO in reversing the anemia associated with malignancy and suggest a role of pO2 histography in monitoring the beneficial effects of EPO therapy. PO-2 117-120 erythropoietin Mus musculus 173-176 8173014-12 1994 The mechanism of high Epo level in SGA fetuses may involve low pO2 and hemoconcentration. PO-2 63-66 erythropoietin Homo sapiens 22-25 8012902-2 1994 Bradykinin relaxed the indomethacin-contracted ductus dose dependently from a threshold of about 10(-10) M, and peak relaxation was greater at high (176-210 mmHg; 1 mmHg = 133.3 Pa) than low (15-25 mmHg) PO2. PO-2 204-207 kininogen 1 Homo sapiens 0-10 8138752-6 1994 Plasma IGF-I was positively associated with fetal weight and fetal liver weight, and with blood pO2 and glucose at both ages. PO-2 96-99 insulin-like growth factor I Ovis aries 7-12 8264050-8 1993 Messenger RNA for tPA was unchanged but PAI-1 mRNA increased significantly for HSVEC and HUVEC after 24 hours of Po2 of 40 mm Hg, returning to baseline within 24 hours of Po2 to 150 mm Hg restoration. PO-2 113-116 serpin family E member 1 Homo sapiens 40-45 8326022-5 1993 Whereas low oxygen tension (PO2 = 20-30 Torr) increases ET-1 expression four- to eightfold above that seen at normal oxygen tension (PO2 = 150 Torr), sodium nitroprusside, which releases NO, suppresses this effect. PO-2 28-31 endothelin 1 Homo sapiens 56-60 8238479-0 1993 Microelectrode measurements of pericellular PO2 in erythropoietin-producing human hepatoma cell cultures. PO-2 44-47 erythropoietin Homo sapiens 51-65 8318163-5 1993 At (r) 1/40 and 1/20, metal ion binding to the PO2- and the guanine N-7 site (chelation) predominates with minor perturbations of the A-T base pairs. PO-2 47-50 angiotensin II receptor type 1 Bos taurus 0-20 8392358-8 1993 We suggest that PO2 changes can alter myofilament responsiveness to Ca2+ and this effect may be related to cyclic AMP-dependent phosphorylation of myosin light chain kinase, its inactivation and subsequent uncoupling between Ca2+ and contractile machinery in smooth muscle. PO-2 16-19 myosin light chain kinase Rattus norvegicus 147-172 8384444-5 1993 This cyanide- and antimycin-insensitive but hypoxia-sensitive cytochrome b would be an attractive candidate for controlled Epo production in response to pO2. PO-2 153-156 mitochondrially encoded cytochrome b Homo sapiens 62-74 8392648-6 1993 Decreasing buffer pO2 led to corresponding decreases in CD16 and CD32w expression. PO-2 18-21 Fc gamma receptor IIIa Homo sapiens 56-60 8384444-5 1993 This cyanide- and antimycin-insensitive but hypoxia-sensitive cytochrome b would be an attractive candidate for controlled Epo production in response to pO2. PO-2 153-156 erythropoietin Homo sapiens 123-126 1491115-5 1992 A hypothetical signal chain is described which suggests the involvement of cytochrome b as an O2 sensor in PO2 chemoreception of the carotid body and the degradation of H2O2 by glutathione to control the K(+)-conductivity of carotid body cells. PO-2 107-110 cytochrome b, mitochondrial Rattus norvegicus 75-87 8194801-9 1993 There are phase fluctuations of the ctO2/pO2 dissociation curve in the reference interval, expressed in the "lowering" of P50 and p90 in mild hypoxia and the "centering" or "raising" of their values in severe hypoxia. PO-2 41-44 activating signal cointegrator 1 complex subunit 1 Homo sapiens 122-125 8194801-9 1993 There are phase fluctuations of the ctO2/pO2 dissociation curve in the reference interval, expressed in the "lowering" of P50 and p90 in mild hypoxia and the "centering" or "raising" of their values in severe hypoxia. PO-2 41-44 cellular inhibitor of PP2A Homo sapiens 130-133 1334969-4 1992 PGI2 synthesis maximally stimulated by bradykinin, A23187, and arachidonic acid were also attenuated at low PO2, by 35%, 33%, and 35%, respectively. PO-2 108-111 kininogen 1 Homo sapiens 39-49 1281830-3 1992 Human endothelial cells (ECs) subjected to hypoxia (PO2 approximately 12-14 Torr) elaborated IL-1 activity into conditioned media in a time-dependent manner; this activity was completely neutralized by an antibody to IL-1 alpha. PO-2 52-55 interleukin 1 alpha Homo sapiens 217-227 1325990-2 1992 Exposure of cells to hypoxia (pO2 approximately 14 torr) followed by reoxygenation led to significant release of IL-1 only from the mononuclear phagocytes. PO-2 30-33 interleukin 1 alpha Homo sapiens 113-117 1445378-5 1992 These results indicate that during the contraction of smooth muscle preparations the levels of ET-1 in the tissue bath are steadily decreasing due to exposure to high pO2 levels. PO-2 167-170 endothelin 1 Homo sapiens 95-99 1305089-1 1992 The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr. PO-2 132-135 ceruloplasmin Mus musculus 90-103 1305089-1 1992 The polarographic method using platinum electrode has been applied to study the effect of ceruloplasmin (CP) on the oxygen tension (pO2), oxygen saturation rate and rate of oxygen utilization in the muscular tissue of high-leukemic AKR mice, C57BL/6 mice with transplanted Lewis lung carcinoma (3LL) and rats after gamma-irradiation in a dose of 7 Gr. PO-2 132-135 ceruloplasmin Mus musculus 105-107 1325990-3 1992 Elaboration of IL-1 was dependent on the oxygen tension and duration of hypoxia (optimal at lower pO2s, approximately 14-20 torr, and after 9 h), as well as the time in reoxygenation (maximal IL-1 release at 6-9 h). PO-2 98-102 interleukin 1 alpha Homo sapiens 15-19 1323727-3 1992 Using a quantitative RNase protection assay, we have demonstrated oxygen-dependent EPO mRNA production in isolated perfused rat kidneys, with EPO mRNA levels increasing 30-fold when perfusate pO2 was reduced from 474 to 25 mm Hg. PO-2 192-195 erythropoietin Rattus norvegicus 83-86 1567422-5 1992 The IP"s of six of the highest occupied orbitals of the phosphate group in 4 and in the model anion 3, predicted from 4-31G SCF calculations, have been corrected by comparing 4-31G SCF results for PO2- to theoretical IP"s obtained from second-order Moller-Plesset perturbation calculations on PO2-. PO-2 197-200 KIT ligand Homo sapiens 181-184 1547365-6 1992 It is found that the tissue PO2 at the lethal corner decreases with the decrease in blood velocity, arterial PO2, hemoglobin concentration, P50, and increase in COHb concentration or metabolic rate, while the difference between end-capillary PO2 and venous PO2 increases, which reflects the effect of nonequilibrium kinetics on the delivery of O2 to tissue. PO-2 28-31 nuclear factor kappa B subunit 1 Homo sapiens 140-143 1342232-5 1992 For both purified Hb and whole blood samples, incubation with papaverine, dipyridamole and nifedipine modified P50 (PO2 for half saturation of the Hb/oxygen sites) at pH 7.4: 30.9 mmHg for 0.72 mM papaverine vs 23.9 mmHg for control; 23.9 mmHg for 1.43 mM dipyridamole vs 20.8 mmHg for control; 1.09 mmHg for 2.73 mM nifedipine vs 1.14 mmHg for control stripped Hb. PO-2 116-119 nuclear factor kappa B subunit 1 Homo sapiens 111-114 1456503-0 1992 [Pertinence of simultaneous measurements of pO2 and sO2 on ABL 510]. PO-2 44-47 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 59-62 1456503-2 1992 ABL instruments by Radiometer were tested by two types of tonometry (film and bubble tonometry) and the validity of the algorithm for pO2 correction was analysed with these results. PO-2 134-137 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 0-3 1943737-5 1991 The plasma ir-endothelin-1 concentration was inversely correlated with arterial blood PO2 in the three study groups (normoxic, mildly hypoxic, and severely hypoxic rats) after 1 hour (n = 18, r = -.74, P less than .01), and after 2 hours (n = 18, r = .71, P less than .01). PO-2 86-89 endothelin 1 Rattus norvegicus 14-26 1562381-9 1992 The P300 latency was well correlated with the PCO2, PO2, pH. PO-2 52-55 E1A binding protein p300 Homo sapiens 4-8 1750523-5 1991 However, in kidneys perfused at low PO2 with a high concentration of each inhibitor, EPO mRNA levels were increased, demonstrating that the ability to respond to hypoxia was retained. PO-2 36-39 erythropoietin Rattus norvegicus 85-88 1812405-3 1991 bolus injection of protirelin tartrate (TRH-T, 4 mg/kg), which produces a prompt and sustained reversal of the shock condition, caused a rapid increase in venous pO2, pCO2 and SO2; on the other hand, arterial and venous pH, bicarbonate and BE continued to decrease--and venous lactate to increase during the first few minutes after treatment. PO-2 162-165 thyrotropin releasing hormone Rattus norvegicus 40-43 1761500-5 1991 Animals given TNF had early (0-4 h) decreases (P less than 0.05) in arterial PO2, increases (P less than 0.05) in physiological shunt fraction and alveolar-to-arterial PO2 gradient, and a high mortality rate (50%). PO-2 77-80 tumor necrosis factor Homo sapiens 14-17 1761500-5 1991 Animals given TNF had early (0-4 h) decreases (P less than 0.05) in arterial PO2, increases (P less than 0.05) in physiological shunt fraction and alveolar-to-arterial PO2 gradient, and a high mortality rate (50%). PO-2 168-171 tumor necrosis factor Homo sapiens 14-17 1761500-8 1991 Animals challenged with TNF and not IL-1 had reversible depression of LVEF similar in time course to abnormalities in arterial PO2. PO-2 127-130 tumor necrosis factor Homo sapiens 24-27 2019268-7 1991 When the arterial pO2 was lowered to 35 or 20 mm Hg, Epo production increased to 0.4 and 0.9 U/g kidney, respectively. PO-2 18-21 erythropoietin Rattus norvegicus 53-56 1910074-6 1991 CCa2+ showed a significant positive correlation with oxygen tension (PO2) (r = 0.71, P less than 0.002). PO-2 69-72 crystallin beta B2 Homo sapiens 0-4 1904467-7 1991 Tyrosinase activity (assayed by the method of Pomerantz) was 300 microU/mg protein at PO2 7-34 mm Hg. PO-2 86-89 tyrosinase Homo sapiens 0-10 2019268-9 1991 These results indicate that the production of Epo in the isolated perfused kidney depends on the availability of O2 and can be modulated by changes in the arterial pO2. PO-2 164-167 erythropoietin Rattus norvegicus 46-49 1649989-3 1991 The erythropoietin production rate was inversely related to the oxygen pressure in the perfusate and increased from 0.17 to 1.85 U erythropoietin h-1 g kidney-1 when arterial PO2 was lowered from 500 mmHg to 30 mmHg. PO-2 175-178 erythropoietin Rattus norvegicus 4-18 2117400-2 1990 Reduction of PO2 from approximately 135 Torr to less than 40 Torr slowly increased SPA and LPA resting tension but did not affect SMA tension. PO-2 13-16 surfactant protein A1 Rattus norvegicus 83-86 1995228-13 1991 Vasodilators such as calcium channel blockers and ACE-inhibitors may improve pulmonary hemodynamics acutely, but may lower arterial PO2 by worsening ventilation-perfusion matching or blunt the improvement in pulmonary hemodynamics seen with supplemental oxygen. PO-2 132-135 angiotensin I converting enzyme Homo sapiens 50-53 1704113-2 1990 Hypoxia (pO2 25 torr) reversibly suppressed K+ currents in a voltage-dependent manner: maximal effects were seen at low, positive test potentials, where the Ca2(+)-activated component of K+ currents was greatest. PO-2 9-12 carbonic anhydrase 2 Homo sapiens 157-160 2129243-1 1990 This study examines the hypotheses that (i) erythropoietin (the hormone responsible for red blood cell production) is higher in the fetus (at low PO2) than in the neonate (at high PO2); and (ii) that the level of erythropoietin in the neonate is influenced by the presence of high oxygen affinity haemoglobin. PO-2 146-149 erythropoietin Ovis aries 44-58 2129243-1 1990 This study examines the hypotheses that (i) erythropoietin (the hormone responsible for red blood cell production) is higher in the fetus (at low PO2) than in the neonate (at high PO2); and (ii) that the level of erythropoietin in the neonate is influenced by the presence of high oxygen affinity haemoglobin. PO-2 180-183 erythropoietin Ovis aries 44-58 2386516-6 1990 These results indicate that Epo production in the IPRK is mainly under the control of the arterial pO2. PO-2 99-102 erythropoietin Rattus norvegicus 28-31 2353306-9 1990 After rIL-2, cardiac output, heart rate, core temperature, and mean pulmonary artery pressure increased (p less than 0.05), whereas systemic vascular resistance and arterial PO2 decreased (p less than 0.05). PO-2 174-177 interleukin 2 Rattus norvegicus 6-11 1965756-3 1990 Exposure to 6% chylomicra, slowly produced a decrease in the pO2 of human blood (37 degrees C, at in vivo pH) amounting to a 6.0 mm Hg leftward shift in the P-50. PO-2 61-64 nuclear factor kappa B subunit 1 Homo sapiens 157-161 2381426-7 1990 The presence of oxygen free radicals at each pH or pO2 resulted in about a 3-fold increase in the release of beta-glucuronidase. PO-2 51-54 glucuronidase, beta Rattus norvegicus 109-127 2381426-8 1990 A combination of very low pO2 and pH (pO2 (mm Hg)/pH; 34/5.5, 34/6.5) resulted in an increased release of beta-glucuronidase from lysosomes. PO-2 26-29 glucuronidase, beta Rattus norvegicus 106-124 2381426-8 1990 A combination of very low pO2 and pH (pO2 (mm Hg)/pH; 34/5.5, 34/6.5) resulted in an increased release of beta-glucuronidase from lysosomes. PO-2 38-41 glucuronidase, beta Rattus norvegicus 106-124 2381426-9 1990 Oxygen free radicals in the presence of both low pO2 and pH resulted in a further increase in the release of beta-glucuronidase. PO-2 49-52 glucuronidase, beta Rattus norvegicus 109-127 34571399-16 2021 Mean pO2 was negatively correlated with local motility (p < 0.01) and positively correlated with DCL, DAP, and VCL (p < 0.05). PO-2 5-8 death associated protein Bos taurus 102-105 2128766-4 1990 The present in vitro studies show that IL-1 and TNF-alpha, but not IFN-gamma significantly lower the pO2-dependent formation of EPO in HepG2 cultures. PO-2 101-104 interleukin 1 alpha Homo sapiens 39-43 2128766-4 1990 The present in vitro studies show that IL-1 and TNF-alpha, but not IFN-gamma significantly lower the pO2-dependent formation of EPO in HepG2 cultures. PO-2 101-104 tumor necrosis factor Homo sapiens 48-57 2128766-4 1990 The present in vitro studies show that IL-1 and TNF-alpha, but not IFN-gamma significantly lower the pO2-dependent formation of EPO in HepG2 cultures. PO-2 101-104 erythropoietin Homo sapiens 128-131 34911756-2 2021 Recently, the mass-independent fractionation of oxygen isotopes (O-MIF) has been used as a tool for estimating pO2 and productivity during the Proterozoic. PO-2 111-114 macrophage migration inhibitory factor Homo sapiens 67-70 34911756-8 2021 Indeed, pO2 levels below 0.8% PAL are possible only if atmospheric methane was more abundant than today (so that pCO2 could have been lower) or if the Sibley O-MIF data were diluted by reprocessing before the sulfates were deposited. PO-2 8-11 macrophage migration inhibitory factor Homo sapiens 160-163 34425506-4 2021 Intracerebroventricular (ICV) administration of nesfatin-1 revealed a hyperventilation response with an increase in TV, RR, RMV, and pO2 and a decrease in pCO2 in saturated Sprague Dawley rats. PO-2 133-136 nucleobindin 2 Rattus norvegicus 48-58 34425506-5 2021 ICV pretreatment with the muscarinic receptor antagonist atropine partially blocked the RR, RMV, pO2, and pCO2 responses produced by nesfatin-1 while completely blocking the TV response. PO-2 97-100 nucleobindin 2 Rattus norvegicus 133-143 34425506-7 2021 The study"s conclusion demonstrated that nesfatin-1 had active hyperventilation effects resulting in an increase in pO2 and a decrease in pCO2. PO-2 116-119 nucleobindin 2 Rattus norvegicus 41-51 2089607-1 1990 The influences of analytical variation of sO2 and pO2 measurements on the oxygen parameters p50, pO2uv-, DavO2c, CQ are examined by simulation. PO-2 50-53 nuclear factor kappa B subunit 1 Homo sapiens 92-95 34571399-16 2021 Mean pO2 was negatively correlated with local motility (p < 0.01) and positively correlated with DCL, DAP, and VCL (p < 0.05). PO-2 5-8 vinculin Bos taurus 111-114 34917631-9 2021 A weak negative correlation (p < 0.05) between pO2 and serum IL-1beta, IL-12, and IL-33 and between SaO2 and serum IL-33 was noted. PO-2 47-50 interleukin 1 alpha Homo sapiens 61-69 34917631-9 2021 A weak negative correlation (p < 0.05) between pO2 and serum IL-1beta, IL-12, and IL-33 and between SaO2 and serum IL-33 was noted. PO-2 47-50 interleukin 33 Homo sapiens 82-87 34824166-8 2022 CONCLUSION: Wearing face masks during exercise showed no effect on LT, limited maximum performance, and induced discrete changes in capillary pCO2 and pO2 within the physiologic range while increasing RPE at LT. PO-2 151-154 FA complementation group E Homo sapiens 20-24 34855654-10 2022 Concurrently, BNP at discharge was correlated with age, central DBP (cDBP), urea, creatinine, LVEDD, partial oxygen pressure (pO2), and oxygen saturation (SO2). PO-2 126-129 natriuretic peptide B Homo sapiens 14-17 34855654-11 2022 Delta BNP was correlated with cSBP, peripheral SBP, urea, creatinine, pO2, and SO2. PO-2 70-73 natriuretic peptide B Homo sapiens 6-9 35468342-1 2022 PURPOSE: The pO2 threshold of an ideal PET hypoxia tracer for radiotherapy planning in cancer would match those observed in clinically and biologically relevant processes such as radioresistance and HIF1alpha expression. PO-2 13-16 hypoxia inducible factor 1 subunit alpha Homo sapiens 199-208 34425031-6 2021 Moreover, treatment of HepG2 cells with hypoxia (1% pO2 ) (n = 3) induced REDD-1, inhibited mTOR complex-1 (mTORC1) activity and increased IGFBP-1 secretion/phosphorylation (Ser101/Ser119/Ser169). PO-2 52-55 DNA damage inducible transcript 4 Homo sapiens 74-80 34425031-6 2021 Moreover, treatment of HepG2 cells with hypoxia (1% pO2 ) (n = 3) induced REDD-1, inhibited mTOR complex-1 (mTORC1) activity and increased IGFBP-1 secretion/phosphorylation (Ser101/Ser119/Ser169). PO-2 52-55 CREB regulated transcription coactivator 1 Mus musculus 108-114 34425031-6 2021 Moreover, treatment of HepG2 cells with hypoxia (1% pO2 ) (n = 3) induced REDD-1, inhibited mTOR complex-1 (mTORC1) activity and increased IGFBP-1 secretion/phosphorylation (Ser101/Ser119/Ser169). PO-2 52-55 insulin like growth factor binding protein 1 Homo sapiens 139-146 34210319-6 2021 FAM13A expression negatively correlated with FEV1% and PO2 in COPD patients. PO-2 55-58 family with sequence similarity 13 member A Homo sapiens 0-6 35523073-8 2022 In mice that overexpressed HAS3, EPR imaging showed an increase in local pO2 that could be linked to increases in perfusion/permeability and local blood volume immediately after PEGPH20 treatment. PO-2 73-76 hyaluronan synthase 3 Mus musculus 27-31 35523073-8 2022 In mice that overexpressed HAS3, EPR imaging showed an increase in local pO2 that could be linked to increases in perfusion/permeability and local blood volume immediately after PEGPH20 treatment. PO-2 73-76 sperm adhesion molecule 1 Mus musculus 178-185 35468342-8 2022 RESULTS: Radioresistance, pimonidazole binding and HIF1alpha expression increased gradually as pO2 decreased between 25 mmHg and 0 mmHg. PO-2 95-98 hypoxia inducible factor 1 subunit alpha Homo sapiens 51-60 2506335-6 1989 The cytochrome P-450 inhibitor SKF-525A (500 microM) nonselectively depressed venular contractions induced by decreased PO2 and pharmacological agents. PO-2 120-123 cytochrome P450 3A14 Cavia porcellus 4-20 35266717-4 2022 Our findings show that AFM-IR spectra of insulin oligomers have strong signals of C-H and PO2- vibrations, which points on the presence of lipids in the oligomer structure. PO-2 90-93 insulin Homo sapiens 41-48 35212063-8 2022 During hospitalization, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 (P/F ratio) <26.6 kPa. PO-2 154-157 lipopolysaccharide binding protein Homo sapiens 51-85 35212063-8 2022 During hospitalization, increased plasma levels of lipopolysaccharide-binding protein (LBP) were strongly associated with respiratory failure, defined as pO2 /fiO2 (P/F ratio) <26.6 kPa. PO-2 154-157 lipopolysaccharide binding protein Homo sapiens 87-90 2806154-6 1989 Increased amniotic fluid AVP levels were found in conditions indicative of fetal stress (viz., lower pH, higher PCO2) without any correlation to fetal growth parameters, while increased amniotic OXT levels were correlated with higher PO2. PO-2 234-237 oxytocin/neurophysin I prepropeptide Homo sapiens 195-198 2489083-5 1989 The elevation in P50 (representing PO2 at which Hb is half saturated) at these doses is mainly due to the new acidic groups which, by unfolding of this globular protein, become exposed in its surface. PO-2 35-38 nuclear factor kappa B subunit 1 Homo sapiens 17-20 2609348-7 1989 These results suggest that the reductive activation to free radicals, catalyzed by cytochrome P-450, and thus the induction of lipid peroxidation at low but physiological PO2 are characteristic not only of CCl4 but also of other polyhalogenated methanes, especially CBrCl3, CBr4, CHI3, CHBr3, and CHBr2Cl. PO-2 171-174 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 83-99 2609348-7 1989 These results suggest that the reductive activation to free radicals, catalyzed by cytochrome P-450, and thus the induction of lipid peroxidation at low but physiological PO2 are characteristic not only of CCl4 but also of other polyhalogenated methanes, especially CBrCl3, CBr4, CHI3, CHBr3, and CHBr2Cl. PO-2 171-174 C-C motif chemokine ligand 4 Rattus norvegicus 206-210 2497503-3 1989 Administration of the cyclooxygenase inhibitor indomethacin blocked the synthesis of prostanoids, so that 6kPGF1 alpha and TXB2 levels decreased to values below the detection level (10 pg.ml-1) both during normoxia or hypoxia, but did not affect pulmonary vascular resistance or the alveolar-arterial PO2 difference (PAi-Pa)O2. PO-2 301-304 prostaglandin-endoperoxide synthase 1 Canis lupus familiaris 22-36 2494273-5 1989 However, in four animals the PA2 activity was elevated and in all cases this was accompanied by a low arterial pO2. PO-2 111-114 phospholipase A2 group IB Rattus norvegicus 29-32 2783928-3 1989 Moderate systemic hypotension, mild pulmonary hypertension, and an increase in alveolar-arterial PO2 gradient was present on day 3 of rIL-2 infusion. PO-2 97-100 interleukin 2 Rattus norvegicus 134-139 16666136-3 1988 When equilibrated at an external pO(2) of 20 kilopascals, leghemoglobin was 36.6 +/- 5.4% oxygenated, a value estimated to represent an infected cell O(2) concentration of 21.5 nanomolar. PO-2 33-38 leghemoglobin A Glycine max 58-71 2973236-6 1988 Plasma atrial natriuretic factor concentration rose concurrently with the fall in PO2 such that atrial natriuretic factor increased to 565 +/- 196 pg/ml from a basal level of 127 +/- 13 pg/ml (p less than 0.001). PO-2 82-85 natriuretic peptides A Ovis aries 96-121 2970232-2 1988 Base-line plasma ANF (range from 29.8 to 219 pg/ml; mean +/- SE = 87.0 +/- 14.1 pg/ml; n = 16 rabbits) was negatively correlated with base-line arterial PO2 (r = -0.759; P less than 0.01) but not with PCO2, pH, mean arterial blood pressure, central venous pressure (CVP), minute ventilation, heart rate, or type of anesthetics used. PO-2 153-156 natriuretic peptides A Oryctolagus cuniculus 17-20 3215851-1 1988 The aim of this paper was to measure the binding of CO to myoglobin and hemoglobin at various PO2 values. PO-2 94-97 myoglobin Homo sapiens 58-67 3215851-3 1988 The results indicate that a significant proportion of CO is released by hemoglobin and binds myoglobin at low PO2 values (approximately 2-3 Torr), in qualitative agreement with the predictions of a previous computer simulation of the "in vivo" system. PO-2 110-113 myoglobin Homo sapiens 93-102 2850391-0 1988 [A study of level of serum angiotensin I converting enzyme in patients with old and inactive pulmonary tuberculosis--in relation to pulmonary function (PO2,%VC,FEV1.0,%FEV1.0)]. PO-2 152-155 angiotensin I converting enzyme Homo sapiens 27-58 3056631-4 1988 The typical increases in lung lymph flow microvascular permeability to protein, transvascular protein flow and transvascular protein clearance, and decrease in systemic arterial PO2 were prevented or significantly attenuated during 5 hours of endotoxemia by the AT-III/alpha 1-PI combination pretreatment. PO-2 178-181 antithrombin-III Ovis aries 262-268 3401014-9 1988 These results provide further evidence for the decisive role of lipid peroxidation, preferentially induced at low PO2, in CCl4 liver injury. PO-2 114-117 C-C motif chemokine ligand 4 Rattus norvegicus 122-126 3195138-2 1988 OHb exhibited high affinity to oxygen (P50 = 17 torr) as well as a decreased rate of the subunits cooperative interaction (n = 1.5-1.6); OHb-PLP possessed P50 = 27 torr, n = 2.2 (for pO2 greater than P50), Bore effect -0.4. PO-2 183-186 proteolipid protein 1 Homo sapiens 141-144 16666136-4 1988 Increasing the external pO(2) from 20 to 25 kilopascals caused a rapid increase in leghemoglobin oxygenation, followed by a recovery to the initial level, all within 7.5 minutes. PO-2 24-29 leghemoglobin A Glycine max 83-96 3148460-3 1988 Compared to a control group, secretin caused a significant increase in pO2 and in O2 saturation (p less than 0.05). PO-2 71-74 secretin Homo sapiens 29-37 3358265-6 1988 A model in which X1 accumulated in proportion to the PO2 and disappeared by first-order decay during periods of low O2 exposure was modified to include an effective rate constant for changes in X1: dX1/dt = a.PO2 + K1. PO-2 53-56 x1 Drosophila melanogaster 17-19 3259225-4 1988 During the rIL-2 infusion there was a dose-dependent significant decrease in systemic blood pressure and arterial Po2 and an increase in core temperature. PO-2 114-117 interleukin 2 Rattus norvegicus 11-16 3327053-2 1987 Capillary blood obtained from puncture of a warmed heel was tested for PO2 monitoring in management of 31 infants (1215-3920 g) with perinatal asphyxia and/or RDS. PO-2 71-74 peripherin 2 Homo sapiens 159-162 3662082-5 1987 Saturation ScO2, computed on-line from mass spectrometer end-tidal PO2 and PCO2, was used to manually adjust FIO2 breath by breath to obtain a rapid fall to a hypoxic plateau lasting 30-45s, followed by rapid resaturation. PO-2 67-70 synthesis of cytochrome C oxidase 2 Homo sapiens 11-15 3327053-5 1987 We confirm the reliability of capillary microsampling collected blood for PO2 monitoring in RDS management too. PO-2 74-77 peripherin 2 Homo sapiens 92-95 3032886-7 1987 The hemodynamic consequences of changing Po2 (i.e., hypoxic vasoconstriction) may alter whole-organ ACE activity in the sense of changing the perfused surface area (i.e., the amount of ACE in contact with flowing perfusate). PO-2 41-44 angiotensin-converting enzyme Oryctolagus cuniculus 100-103 3565558-6 1987 An increase in CAT and GPx activity per cell resulted on exposing fibroblasts to Dex in the presence of low PO2. PO-2 108-111 catalase Rattus norvegicus 15-18 3032886-7 1987 The hemodynamic consequences of changing Po2 (i.e., hypoxic vasoconstriction) may alter whole-organ ACE activity in the sense of changing the perfused surface area (i.e., the amount of ACE in contact with flowing perfusate). PO-2 41-44 angiotensin-converting enzyme Oryctolagus cuniculus 185-188 3802439-5 1987 P50, 2,3-DPG, hemoglobin concentrations, and O2 saturation varied widely and inconsistently with Po2 and arterial and venous O2 content, but resulted in clustering of the arterial oxygen content near 165 +/- 23 (SD) ml/liter over a wide range of Po2 and hemoglobin concentrations. PO-2 97-100 nuclear factor kappa B subunit 1 Homo sapiens 0-3 3802439-5 1987 P50, 2,3-DPG, hemoglobin concentrations, and O2 saturation varied widely and inconsistently with Po2 and arterial and venous O2 content, but resulted in clustering of the arterial oxygen content near 165 +/- 23 (SD) ml/liter over a wide range of Po2 and hemoglobin concentrations. PO-2 246-249 nuclear factor kappa B subunit 1 Homo sapiens 0-3 3453066-10 1987 They rather indicate that excitation of these pO2-sensors in normoxic humans suppresses plasma AVP by mechanisms so far unknown. PO-2 46-49 arginine vasopressin Homo sapiens 95-98 6477950-3 1984 Under these conditions, at the hypoxic end of the physiological PO2 in liver, CCl4 caused a 5-fold increase in the oxygen uptake rate and a 20-fold increase in the malondialdehyde formation rate while, at 80 mmHg (10.7 kPa) the haloalkane caused only an increase of 2- and 4-fold, respectively; in comparison, there was only a slight increase in NADPH-induced lipid peroxidation with increasing PO2. PO-2 64-67 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 3508440-3 1987 Monitoring of hepatocellular oxygen uptake, malondialdehyde-formation and low-level chemiluminescence during incubations of CCl4-supplemented hepatocytes indicated a drastic stimulation of lipid peroxidation at pO2-levels between 1 and 10 mmHg. PO-2 211-214 C-C motif chemokine ligand 4 Rattus norvegicus 124-128 3508440-5 1987 The evaluation of cellular damages by determining trypan blue exclusion and lactate dehydrogenase leakage revealed that in the presence of CCl4 hepatocellular injury was significantly increased at those pO2-levels which were optimal for CCl4-mediated lipid peroxidation. PO-2 203-206 C-C motif chemokine ligand 4 Rattus norvegicus 139-143 3508440-5 1987 The evaluation of cellular damages by determining trypan blue exclusion and lactate dehydrogenase leakage revealed that in the presence of CCl4 hepatocellular injury was significantly increased at those pO2-levels which were optimal for CCl4-mediated lipid peroxidation. PO-2 203-206 C-C motif chemokine ligand 4 Rattus norvegicus 237-241 3508440-6 1987 The present results demonstrate that CCl4 is a potent inducer of lipid peroxidation also in the intact hepatocyte, provided that the pO2 is maintained at distinct low levels. PO-2 133-136 C-C motif chemokine ligand 4 Rattus norvegicus 37-41 3711943-2 1986 With decreasing temperature, P50 (the oxygen tension [PO2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension (PvO2) and thus low tissue PO2 values. PO-2 54-57 nuclear factor kappa B subunit 1 Homo sapiens 29-32 3711943-2 1986 With decreasing temperature, P50 (the oxygen tension [PO2] at 50% hemoglobin saturation with oxygen) decreases, thereby leading to low mixed venous oxygen tension (PvO2) and thus low tissue PO2 values. PO-2 190-193 nuclear factor kappa B subunit 1 Homo sapiens 29-32 3711943-9 1986 Sensitivity analysis predicts that during hypothermia PvO2 (and thus tissue PO2) is very dependent on P50, hemoglobin concentration, and QT, and less dependent on oxygen solubility and arterial PO2. PO-2 76-79 nuclear factor kappa B subunit 1 Homo sapiens 102-105 4046869-9 1985 It was demonstrated that, within the hematocrit range of 20 to 45%, the elevation of P50 from 27 to 38 mm Hg in sickle cell blood is adequate to compensate for the diminished O2 content, despite an elevated blood viscosity, and maintain near normal tissue pO2. PO-2 256-259 nuclear factor kappa B subunit 1 Homo sapiens 85-88 3933197-3 1985 With a secretin infusion alone (0 to 60 mins) there was a transient, significant rise in PO2 (p less than 0.01) and oxygen saturation (p less than 0.05), which was no longer detectable after 60 minutes (p greater than 0.05). PO-2 89-92 secretin Homo sapiens 7-15 3933197-8 1985 The isolated increase in PO2 and O2 saturation may be attributed to vasodilation induced by secretin. PO-2 25-28 secretin Homo sapiens 92-100 6442560-11 1984 The rates of glucose uptake and lactate production increased while the rates of 14CO2 production from C-1- and C-6-labelled glucose decreased as the PO2 decreased. PO-2 149-152 complement component C6 Ovis aries 102-114 3953817-7 1986 This difference in PO2 response to the two compounds is interpreted in light of the fact that CCK-OP primarily stimulates acinar cell function, while secretin preferentially activates secretory epithelium. PO-2 19-22 secretin Rattus norvegicus 150-158 6477950-3 1984 Under these conditions, at the hypoxic end of the physiological PO2 in liver, CCl4 caused a 5-fold increase in the oxygen uptake rate and a 20-fold increase in the malondialdehyde formation rate while, at 80 mmHg (10.7 kPa) the haloalkane caused only an increase of 2- and 4-fold, respectively; in comparison, there was only a slight increase in NADPH-induced lipid peroxidation with increasing PO2. PO-2 395-398 C-C motif chemokine ligand 4 Rattus norvegicus 78-82 6477950-4 1984 These data clearly demonstrate the critical role of low steady-state PO2 in CCl4-induced lipid peroxidation and support lipid peroxidation as a key factor in CCl4 hepatotoxicity. PO-2 69-72 C-C motif chemokine ligand 4 Rattus norvegicus 76-80 6475110-8 1984 Numerous determinations of the arterial and venous pO2 resting levels have shown that the values of eta can almost be doubled easily by the procedures of the Oxygen Multistep Therapy, whereby--as a rule--the age-dependent decrease of the cardiac output is overcompensated. PO-2 51-54 endothelin receptor type A Homo sapiens 100-103 7356899-1 1980 1 The definition of PO2 and its relationship to the oxygen saturation (SO2) by the oxygen dissociation curve (ODC) is described with details of the ligands of the ODC and the effects of haemoglobinopathies on P50 (the position of the ODC) and the slope of the ODC (Hill"s "n"). PO-2 20-23 nuclear factor kappa B subunit 1 Homo sapiens 209-212 6346323-3 1983 The production of erythropoietin by these cells was significantly enhanced by either lowering the PO2 in the incubation atmosphere or by adding cobalt chloride to the culture medium. PO-2 98-101 erythropoietin Rattus norvegicus 18-32 6602085-5 1983 However, vasopressin treatment lowered the pO2 in the liver significantly. PO-2 43-46 arginine vasopressin Homo sapiens 9-20 7085405-1 1982 A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption. PO-2 149-152 nuclear factor kappa B subunit 1 Homo sapiens 106-109 7085405-1 1982 A simple expression is derived to describe the partial pressure at 50% hemoglobin saturation with oxygen (P50) that maximizes venous oxygen tension (PO2) for a given arterial PO2 and oxygen consumption. PO-2 175-178 nuclear factor kappa B subunit 1 Homo sapiens 106-109 7319893-6 1981 These findings suggest that cytochrome P-450 could act as a carrier for O2 and CO in tissue with low PO2"s. PO-2 101-104 cytochrome P-450 Oryctolagus cuniculus 28-44 6794946-2 1981 Equilibrated blood is analyzed for oxygen saturation, pH, and organic phosphate concentration with standard techniques, and its p50 (the pO2 at which hemoglobin is half-saturated with oxygen) is determined with full control of all the variables known to affect it. PO-2 137-140 nuclear factor kappa B subunit 1 Homo sapiens 128-131 6257420-5 1981 Using BK as substrate, we found that placental and fetal ACE activities were reflected by 45% (SD = 10) and 24% (SD = 7) clearances, respectively, at a perfusate PO2 of 29 mm Hg. PO-2 162-165 LOW QUALITY PROTEIN: angiotensin-converting enzyme Cavia porcellus 57-60 6442511-0 1984 Tissue pO2 and pCO2 in the gastrointestinal tract and liver during intravenous vasopressin infusion. PO-2 7-10 vasopressin Sus scrofa 79-90 6442511-7 1984 Vasopressin infusion caused significant fall in the tissue pO2 and increase in the pCO2 throughout the gastrointestinal tract. PO-2 59-62 vasopressin Sus scrofa 0-11 6534112-2 1984 The P50 at which beta reaches its maximum is high at normoxia and decreases with lowering the ambient PO2. PO-2 102-105 nuclear factor kappa B subunit 1 Homo sapiens 4-7 6534126-0 1984 The effect of myoglobin concentration on muscle cell PO2 gradients. PO-2 53-56 myoglobin Homo sapiens 14-23 6436930-1 1984 Vasopressin has been found to significantly decrease tissue pO2 in the gastrointestinal tract and the liver. PO-2 60-63 arginine vasopressin Homo sapiens 0-11 7091207-5 1982 P50 (oxygen affinity, i.e., Po2 at 50% oxygen saturation) at actual pH correlated inversely with Hb Alc of the diabetic women (r = -0.45, p less than 0.05). PO-2 28-31 nuclear factor kappa B subunit 1 Homo sapiens 0-3 7172996-1 1982 Miniature PO2 and pH sensors can be used in combination with enzymatic catalysts such as glucose oxidase and glucose dehydrogenase as the basis for the development of a small glucose sensor. PO-2 10-13 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase Homo sapiens 109-130 6301325-11 1982 Preliminary data indicate that the potency of these peptides in causing prostanoid release is, as might be expected, closely correlated to ACE activity, which itself is a function of ambient PO2. PO-2 191-194 angiotensin-converting enzyme Ovis aries 139-142 6127643-3 1982 When the tissue PO2 was elevated to a level high enough to saturate hemoglobin, the ODR reflected the oxygen consumption rate which was calculated to range from 1.6-7.4 cc O2/100 cc tissue-min. PO-2 16-19 immunoglobulin kappa variable 1D-39 Homo sapiens 172-178 391160-4 1979 Discontinuation of CPAP at 6 cmH2O resulted in a mean change in PO2 from 66 to 64 mmHg (8.8 to 8.5 kPa) and a mean change in PCO2 from 41 to 40 mmHg (5.4 to 5.3 kPa). PO-2 64-67 centromere protein J Homo sapiens 19-23 228731-2 1979 When no special efforts were made to maintain a high pO2 in these reaction mixtures catalase protected the xanthine oxidase, but superoxide dismutase did not. PO-2 53-56 catalase Homo sapiens 84-92 41846-0 1979 Plasma beta-endorphin and beta-lipotropin in the human fetus at delivery: correlation with arterial pH and pO2. PO-2 107-110 proopiomelanocortin Homo sapiens 7-21 41344-6 1979 After the inhibition of DBH, the degree of the increase in cerebrocortical PO2 during 5% CO2 inhalation was enhanced while the degree of the decrease in cerebrocortical PO2 during hyperventilation did not show any significant change. PO-2 75-78 dopamine beta-hydroxylase Homo sapiens 24-27 468992-0 1979 Relationship between alveolar PO2 and the rate of p-nitroanisole O-demethylation by the cytochrome P-450 pathway in isolated rabbit lungs. PO-2 30-33 cytochrome P-450 Oryctolagus cuniculus 88-104 41344-6 1979 After the inhibition of DBH, the degree of the increase in cerebrocortical PO2 during 5% CO2 inhalation was enhanced while the degree of the decrease in cerebrocortical PO2 during hyperventilation did not show any significant change. PO-2 169-172 dopamine beta-hydroxylase Homo sapiens 24-27 34418-4 1979 The effect of 2,3-DPG on the position of the OEC (p50, the pO2 at one-half maximal O2 saturation) is via its allosteric effect on haemoglobin at 2,3-DPG/haemoglobin less than 1. PO-2 59-62 nuclear factor kappa B subunit 1 Homo sapiens 50-53 678250-3 1978 The SDH activity was significantly reduced during a 3-h exposure to a PO2 of 3796 mm Hg. PO-2 70-73 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 4-7 689201-3 1978 An obvious reverse interrelationship existed between plasma erythropoietin activity and value of pO2 and blood supply of the cortex. PO-2 97-100 erythropoietin Rattus norvegicus 60-74 19152-1 1977 The ability of several beta-adrenoceptor antagonists with partial agonist activity (dl-oxprenolol, dl-acebutolol and dl-practolol) to attenuate the release of CPK that occurs during hypoxia (pO2 less than 0.8 kPa [6 MMHg]) has been studied and compared with the protection provided by dl-propranolol. PO-2 191-194 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha Homo sapiens 159-162 20293-4 1977 The qualitative difference in response to CO exposure in the two groups of animals may be due to differences in the sensitivity of cytochrome P-450 and cytochrome P-448 with respect to complexing with CO or to lowered intracellular PO2; or to differences in the dependency on blood flow of the rate of in vivo metabolism of zoxazolamine. PO-2 232-235 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 131-147 20293-4 1977 The qualitative difference in response to CO exposure in the two groups of animals may be due to differences in the sensitivity of cytochrome P-450 and cytochrome P-448 with respect to complexing with CO or to lowered intracellular PO2; or to differences in the dependency on blood flow of the rate of in vivo metabolism of zoxazolamine. PO-2 232-235 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 152-168 853452-16 1977 The concentration of Erythropoietin in the serum of hypoxic rats was progressively elevated as the arterial PO2 of the animals was reduced. PO-2 108-111 erythropoietin Rattus norvegicus 21-35 899912-4 1977 Work with different species suggests that as PO2 rises at birth the relaxant effect of PGEs on the ductal muscle decreases. PO-2 45-48 prostaglandin E synthase Homo sapiens 87-91 951157-0 1976 Letter: Reliability of transcutaneous PO2 with Roche Oxygen Monitor 5300 at 44 C in newborn infants with RDS. PO-2 38-41 peripherin 2 Homo sapiens 105-108 835887-0 1977 Crossover PO2, a measure of the variable effect of increased P50 on mixed venous PO2. PO-2 10-13 nuclear factor kappa B subunit 1 Homo sapiens 61-64 835887-4 1977 I demonstrate that in hypoxemic patients, especially if anemia and shock are present, the arterial Po2 may be less than the crossover Po2; thus, an increased blood P50, the Po2 at oxygen saturation of 50 per cent (pH 7.40, temperature 37 degrees C), cannot increase the mixed venous Po2. PO-2 99-102 nuclear factor kappa B subunit 1 Homo sapiens 164-167 835887-4 1977 I demonstrate that in hypoxemic patients, especially if anemia and shock are present, the arterial Po2 may be less than the crossover Po2; thus, an increased blood P50, the Po2 at oxygen saturation of 50 per cent (pH 7.40, temperature 37 degrees C), cannot increase the mixed venous Po2. PO-2 134-137 nuclear factor kappa B subunit 1 Homo sapiens 164-167 835887-4 1977 I demonstrate that in hypoxemic patients, especially if anemia and shock are present, the arterial Po2 may be less than the crossover Po2; thus, an increased blood P50, the Po2 at oxygen saturation of 50 per cent (pH 7.40, temperature 37 degrees C), cannot increase the mixed venous Po2. PO-2 134-137 nuclear factor kappa B subunit 1 Homo sapiens 164-167 835887-4 1977 I demonstrate that in hypoxemic patients, especially if anemia and shock are present, the arterial Po2 may be less than the crossover Po2; thus, an increased blood P50, the Po2 at oxygen saturation of 50 per cent (pH 7.40, temperature 37 degrees C), cannot increase the mixed venous Po2. PO-2 134-137 nuclear factor kappa B subunit 1 Homo sapiens 164-167 867248-0 1977 [Effect of insulin, cocarboxylase and angiotrophine on pO2 of the tissue in patients with diabetes mellitus]. PO-2 55-58 insulin Homo sapiens 11-18 966176-5 1976 The relationship of the reciprocal of r to the ratio PO2/PCO is non-linear, and a different curve is obtained at each carbon monoxide concentration. PO-2 53-56 PCOS1 Homo sapiens 57-60 981807-5 1976 Prophylactic injection of increasing doses (1, 2, 4, 8, 16 U/kg secretin maintained microcirculation at pO2-levels subnormal for unstressed animals (Vmax 15.53 mm Hg; Km. PO-2 104-107 secretin Rattus norvegicus 64-72 981807-8 1976 Secretin therapy (4, 8 U/kg) markedly improves both mucosal pO2 and ulcer index. PO-2 60-63 secretin Rattus norvegicus 0-8 1200486-3 1975 The arterial-alveolar PN2 difference was nearly one half of the PO2 difference, both early in the disease and at a more advanced stage. PO-2 64-67 amyloid beta precursor protein Homo sapiens 22-25 1273510-3 1976 The direct effects of changes in pO2, pCO2, pH and various cell nutrients on cells producing erythropoietin is now possible. PO-2 33-36 erythropoietin Ovis aries 93-107 943670-0 1976 [Transcutaneous measurements of pO2 in newborns with RDS (author"s transl)]. PO-2 32-35 peripherin 2 Homo sapiens 53-56 33497181-11 2021 Following the direct injection of CAT-SiNPs in the left kidney, partial pressure of oxygen (pO2) increased by more than 30 mmHg compared to the contralateral control kidney during the systemic infusion of safe levels of H2O2. PO-2 92-95 catalase Rattus norvegicus 34-37 4950-2 1975 The different values of PCO2, PO2, pH and alcaline reserve measured on samples of CSF in comatose patients prove the central acidosis related to metabolic and vascular disorders in the damaged areas. PO-2 30-33 colony stimulating factor 2 Homo sapiens 82-85 1105228-19 1975 The changes of artero-mixed venous oxygen saturation difference which were calculated at 100 mmHg of PaO2 and 40mmHg of mixed venous PO2 were in a linear fashion with those of P50. PO-2 133-136 activating signal cointegrator 1 complex subunit 1 Homo sapiens 176-179 5980541-0 1966 Influence of pH, pCO2 and pO2 on erythrocytic adsorption of fibrinogen. PO-2 26-29 fibrinogen beta chain Homo sapiens 60-70 234122-0 1975 Blood P50 calculated from a single measurement of pH, PO2, and SO2. PO-2 54-57 nuclear factor kappa B subunit 1 Homo sapiens 6-9 234122-1 1975 P50 was calculated from a single measurement of pH, Po2, and So2 at a known temperature in 135 blood samples from 21 normal nonsmokers and eight patients. PO-2 52-55 nuclear factor kappa B subunit 1 Homo sapiens 0-3 5727770-0 1968 Uncovered platinum electrodes for the measurement of delta PO2 as an aid in diagnostic cardiac catheterization. PO-2 59-62 activation induced cytidine deaminase Homo sapiens 69-72 4388131-0 1968 [The redox condition of NAD (P) and of cytochrome b and c2 in relation to the pO2 in various Athiorodaceae]. PO-2 78-81 mitochondrially encoded cytochrome b Homo sapiens 39-51 34002323-0 2021 Modulation of lung cytoskeletal remodeling, RXR based metabolic cascades and inflammation to achieve redox homeostasis during extended exposures to lowered pO2. PO-2 156-159 retinoid X receptor alpha Homo sapiens 44-47 33736588-10 2021 PO2 and Pco2 were not correlated with liver function, although PO2 was correlated with albumin. PO-2 63-66 albumin Homo sapiens 87-94 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 hypoxia inducible factor 1 subunit alpha Homo sapiens 144-154 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 BCL2 interacting protein 3 Homo sapiens 207-212 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 pyruvate dehydrogenase kinase 1 Homo sapiens 214-218 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 vascular endothelial growth factor A Homo sapiens 220-224 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 pyruvate kinase M1/2 Homo sapiens 226-230 33920906-4 2021 Specifically, exposing NK cells to 7-9 days of normoxic culture followed by a pO2 of 1.5% hypoxia led to a highly potent effector phenotype via HIF-1alpha stabilization and upregulation of its target genes, BNIP3, PDK1, VEGF, PKM2, and LDHA. PO-2 78-81 lactate dehydrogenase A Homo sapiens 236-240 33483548-3 2021 The goal of this exploratory study was to establish a technique to noninvasively characterize placental partial pressure of oxygen (PO2) in vivo in the Lgals1 (lectin, galactoside-binding, soluble, 1) deficient mouse model of preeclampsia using fluorine magnetic resonance imaging. PO-2 132-135 lectin, galactose binding, soluble 1 Mus musculus 152-158 33483548-13 2021 PO2 in Lgals1 knockout animals was decreased but this effect was only present at 30% oxygen in breathing air, not at 60% and 100%. PO-2 0-3 lectin, galactose binding, soluble 1 Mus musculus 7-13 32926931-11 2020 BNP level showed positive correlation with HbA1c (r = 0.49, p = 0.04) and negative correlation with delta pO2 (r = -0.52, p = 0.04) can predict reduced microvascular compliance due to endothelial dysfunction contributing to hypoxia susceptibility in healthy individuals. PO-2 106-109 natriuretic peptide B Homo sapiens 0-3 33575659-1 2021 Purpose: To assess the cell-specific, intracellular partial pressure of oxygen (Po2) dynamics of both tumor and chimeric antigen receptor (CAR) T cells in a murine immunotherapy model. PO-2 80-83 nuclear receptor subfamily 1, group I, member 3 Mus musculus 112-137 33575659-1 2021 Purpose: To assess the cell-specific, intracellular partial pressure of oxygen (Po2) dynamics of both tumor and chimeric antigen receptor (CAR) T cells in a murine immunotherapy model. PO-2 80-83 nuclear receptor subfamily 1, group I, member 3 Mus musculus 139-142 33575659-6 2021 Results: The intracellular tumor cell Po2 temporal dynamics exhibited delayed, transient hyperoxia at 3 days after infusion of CAR T cells, commensurate with significant tumor cell killing and CAR T-cell infiltration, as observed by bioluminescence imaging and histologic findings. PO-2 38-41 nuclear receptor subfamily 1, group I, member 3 Mus musculus 127-130 33575659-6 2021 Results: The intracellular tumor cell Po2 temporal dynamics exhibited delayed, transient hyperoxia at 3 days after infusion of CAR T cells, commensurate with significant tumor cell killing and CAR T-cell infiltration, as observed by bioluminescence imaging and histologic findings. PO-2 38-41 nuclear receptor subfamily 1, group I, member 3 Mus musculus 193-196 33450375-2 2021 Specialized tissues utilize a conserved mitochondrial sensor, often involving NDUFS2 in complex I of the mitochondrial electron transport chain, as a site of pO2-responsive production of reactive oxygen species (ROS). PO-2 158-161 NADH:ubiquinone oxidoreductase core subunit S2 Homo sapiens 78-84 33403775-9 2021 In parallel with CRP, PO2/FiO2 ratio increased progressively during the three steps from 183+-95 to 361+-144 mmHg (p < 0.001). PO-2 22-25 C-reactive protein Homo sapiens 17-20 33037242-1 2020 Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and critically determines cellular oxygen availability. PO-2 62-65 nuclear factor kappa B subunit 1 Homo sapiens 51-54 33143240-3 2020 The expression of EPO is strictly regulated by local changes in oxygen partial pressure (pO2) as under-deprived oxygen (hypoxia); the transcription factor hypoxia-inducible factor-2 induces EPO. PO-2 89-92 erythropoietin Homo sapiens 18-21 32921997-9 2020 In addition, level of serum HIF-1alpha concentration was significantly correlated with PCO2 (r = 0.283, P<0.001), but negatively and significantly correlated with PO2 (r = -0.490, P=0.005) or FEV1%(r = -0.420, P=0.018). PO-2 163-166 hypoxia inducible factor 1 subunit alpha Homo sapiens 28-38 32208891-2 2020 BL6 mice with global deletion of Olfr78 manifested an impaired hypoxic ventilatory response (HVR), a hallmark of the CB chemo sensory reflex, CB sensory nerve activity, and reduced [Ca2+]i response of glomus cells to hypoxia (pO2 ~40 mmHg). PO-2 226-229 olfactory receptor family 51 subfamily E member 2 Mus musculus 33-39 32208891-3 2020 In contrast, severe hypoxia (pO2 ~10 mmHg) which depressed breathing and produced a very weak CB sensory nerve excitation but robust elevation of [Ca2+]i in Olfr78 null glomus cells. PO-2 29-32 olfactory receptor family 51 subfamily E member 2 Mus musculus 157-163 31550123-4 2019 Specifically, Co5(PO4)2(OH)4 deposited on glassy carbon electrode (loading amount 0.553 mg cm-2) can exhibit an unprecedented overpotential of 254 mV to drive a current density of 10 mA cm-2 with a small Tafel slope of 57 mV dec-1 in alkaline electrolytes, which outperforms the ones of CO3(PO4)2 (370 mV) and Co(OH)2 (360 mV) as well as other advanced catalysts. PO-2 14-28 deleted in esophageal cancer 1 Homo sapiens 226-231 31777937-3 2020 Mouse DXO catalyzes the elimination of incomplete 5"-end caps (including pyrophosphate) and the non-canonical NAD+ cap on mRNAs, and possesses distributive 5"-3" exoribonuclease activity toward 5"-monophosphate (5"-PO4) RNA. PO-2 212-218 decapping exoribonuclease Mus musculus 6-9 31890820-6 2020 The modification of Ag3PO4 by defect and platinum complexes dopant had changed the curve profile of Ag4d, P2p and O1s. PO-2 20-26 pyrimidinergic receptor P2Y4 Homo sapiens 106-109 30841739-2 2019 For some BGMS using glucose oxidase (GOx)-based test strips, one of these factors is the oxygen partial pressure (pO2) of the applied blood sample. PO-2 114-117 hydroxyacid oxidase 1 Homo sapiens 20-35 30841739-2 2019 For some BGMS using glucose oxidase (GOx)-based test strips, one of these factors is the oxygen partial pressure (pO2) of the applied blood sample. PO-2 114-117 hydroxyacid oxidase 1 Homo sapiens 37-40 30841739-4 2019 METHOD: Influence of pO2 was investigated for two GOx-based BGMS (BGMS A and B). PO-2 21-24 hydroxyacid oxidase 1 Homo sapiens 50-53 30841739-9 2019 CONCLUSIONS: This proof of concept study showed that with the procedures used, a potentially clinically relevant influence of pO2 in capillary blood samples on GOx-based BGMS could be detected. PO-2 126-129 hydroxyacid oxidase 1 Homo sapiens 160-163 31502323-6 2019 After childbirth, RD2 group had significantly higher PO2 result than other three groups (P < 0.05). PO-2 53-56 peripherin 2 Homo sapiens 18-21 31722405-1 2019 Fungal tRNA ligase (Trl1) rectifies RNA breaks with 2",3"-cyclic-PO4 and 5"-OH termini. PO-2 52-68 tRNA-Leu (anticodon AAG) 2-3 Homo sapiens 20-24 31638368-3 2019 Here, a "self-sacrifice" interface established by a flexible Li1.5Al0.5Ge1.5(PO4)3 (LAGP)/30% poly(propylene carbonate) (PPC) solid composite electrolyte causes a performance enhancement of the LiFePO4/Li battery with a discharge specific capacity of 151 mA h g-1 at 0.05 C and a retention of 92.3% for 100 cycles at 55 C without any liquid electrolyte, where the PPC-derived layer swells the Li metal and infiltrates to develop the amorphous state to reduce both interfacial and bulk resistance; while the LAGP with good mechanical strength and the LiF layer provides stability and resists the growth of Li dendrites, which guaranteed the long cycle life and security of batteries. PO-2 75-82 LIF interleukin 6 family cytokine Homo sapiens 194-197 31560533-4 2019 In the present study we employed a diphosphonate containing a protonated amine, 1-ammoniummethylenediphosphonate [NH3CH(PO3)23-; (Hamdp)], as the ligand to construct paddlewheel Ru2(Hamdp)2 building block. PO-2 114-126 doublecortin domain containing 2 Homo sapiens 178-181 31499004-2 2019 Factor-inhibiting HIF-1 (FIH) is a nonheme Fe(II) alpha-ketoglutarate-dependent oxygenase that is a key hypoxia (low pO2) sensor in humans. PO-2 117-120 hypoxia inducible factor 1 subunit alpha inhibitor Homo sapiens 0-23 31560362-3 2019 Rb3SbF3(NO3)3 is a potential UV nonlinear optical material due to its large phase-matchable second harmonic generation (SHG) response of approximately 2.2 times that of KH2PO4 (KDP) and a wide band gap of 3.75 eV. PO-2 169-175 NBL1, DAN family BMP antagonist Homo sapiens 8-11 31499004-2 2019 Factor-inhibiting HIF-1 (FIH) is a nonheme Fe(II) alpha-ketoglutarate-dependent oxygenase that is a key hypoxia (low pO2) sensor in humans. PO-2 117-120 hypoxia inducible factor 1 subunit alpha inhibitor Homo sapiens 25-28 29862863-3 2019 In KIR6.1 deficient mice resting cerebral blood flow and brain parenchymal partial pressure of oxygen (PO2) were found to be markedly lower compared to that in their wildtype littermates. PO-2 103-106 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 3-9 29862863-5 2019 These data suggest that KATP channels containing KIR6.1 subunit are critically important for the maintenance of normal cerebral perfusion and parenchymal PO2 but play no significant role in the mechanisms underlying functional changes in brain blood flow. PO-2 154-157 potassium inwardly-rectifying channel, subfamily J, member 8 Mus musculus 49-55 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 glutamate-ammonia ligase Homo sapiens 19-39 31673566-4 2019 Data from two-photon phosphorescence lifetime microscopy indicate that old ATX mice had lower and more heterogeneous partial pressure of oxygen ( PO 2 ) in cortical tissue than young ATX mice. PO-2 147-151 ectonucleotide pyrophosphatase/phosphodiesterase 2 Mus musculus 75-78 31537830-11 2019 On the contrary, carbamoyl-phosphate synthetase 1 (CPS1), ALB, the proliferative marker ki67 (MKI67) and cyclin A (CCNA) resulted to be significantly higher expressed in cells cultured in high pO2 compared to those cultured in low pO2. PO-2 231-234 carbamoyl-phosphate synthase 1 Homo sapiens 17-49 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 glutamate-ammonia ligase Homo sapiens 41-45 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 catenin beta 1 Homo sapiens 48-60 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 catenin beta 1 Homo sapiens 62-67 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 cyclin D1 Homo sapiens 91-100 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 174-177 cyclin D1 Homo sapiens 102-107 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 glutamate-ammonia ligase Homo sapiens 19-39 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 glutamate-ammonia ligase Homo sapiens 41-45 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 catenin beta 1 Homo sapiens 48-60 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 catenin beta 1 Homo sapiens 62-67 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 cyclin D1 Homo sapiens 91-100 31537830-10 2019 The mRNA levels of glutamine synthetase (GLUL), beta-catenin (CTNNB) and its direct target cyclin D1 (CCND1) showed significantly higher expression in the cells grown in low pO2 compared to those grown in high pO2. PO-2 210-213 cyclin D1 Homo sapiens 102-107 31537830-11 2019 On the contrary, carbamoyl-phosphate synthetase 1 (CPS1), ALB, the proliferative marker ki67 (MKI67) and cyclin A (CCNA) resulted to be significantly higher expressed in cells cultured in high pO2 compared to those cultured in low pO2. PO-2 193-196 carbamoyl-phosphate synthase 1 Homo sapiens 17-49 30964701-9 2019 Increased fetal norepinephrine and cortisol concentrations and hepatic G6PC and PCK1 expression were inversely related to fetal arterial Po2. PO-2 137-140 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 71-75 31250556-6 2019 In this study, we demonstrated that CSA is a potent chondrogenic inducer, specifically in combination with acidic medium and low pO2 . PO-2 129-132 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 36-39 30964701-9 2019 Increased fetal norepinephrine and cortisol concentrations and hepatic G6PC and PCK1 expression were inversely related to fetal arterial Po2. PO-2 137-140 phosphoenolpyruvate carboxykinase 1 Homo sapiens 80-84 31346362-5 2019 Such an alteration increases the distance between cells and vessels with a drop in pO2 that, in turn, causes both necrotic cell death and activation of the hypoxia transcription factor HIF-1alpha. PO-2 83-86 hypoxia inducible factor 1 subunit alpha Homo sapiens 185-195 30738311-8 2019 In contrast, trophoblasts submitted to low/high pO2 changes, exhibited oxidative stress and a (DTT reversible) S-glutathionylation of eNOS, associated with reduced NO production and migration. PO-2 48-51 nitric oxide synthase 3 Homo sapiens 134-138 30959909-7 2019 We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1). PO-2 19-22 aggrecan Homo sapiens 96-100 30959909-7 2019 We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1). PO-2 19-22 collagen type II alpha 1 chain Homo sapiens 102-108 30959909-7 2019 We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1). PO-2 19-22 collagen type I alpha 1 chain Homo sapiens 157-163 30959909-7 2019 We identified 2.5% pO2 as an oxygen tension optimally improving chondrocytic marker expression (ACAN, COL2A1), while suppressing de-differentiation markers (COL1A1, COL3A1). PO-2 19-22 collagen type III alpha 1 chain Homo sapiens 165-171 30959909-8 2019 Expression of TGF-beta isoform 2 (TGFB2) was, relatively, most responsive to 2.5% pO2, while all three isoforms were induced by physoxia. PO-2 82-85 transforming growth factor beta 2 Homo sapiens 14-32 30959909-8 2019 Expression of TGF-beta isoform 2 (TGFB2) was, relatively, most responsive to 2.5% pO2, while all three isoforms were induced by physoxia. PO-2 82-85 transforming growth factor beta 2 Homo sapiens 34-39 30738311-9 2019 The autonomous production of NO seemed necessary for the migratory potential of HTR8, as suggested by the inhibitory effect of eNOS silencing by small interfering RNAs, and the eNOS inhibitor L-NAME, in low pO2 conditions. PO-2 207-210 nitric oxide synthase 3 Homo sapiens 127-131 30917851-11 2019 Likewise, a higher expression of TNF-alpha (P = 0.0127), IL-1beta (P = 0.0013), IL-6 (P = 0.0007), and iNOS (P = 0.0013) in lung tissue was determined after exposure to PO2 oscillations. PO-2 169-172 tumor necrosis factor Homo sapiens 33-42 30917851-13 2019 Results of the microarray analysis suggest that inflammatory (IL-6) and oxidative stress (NO/ROS) signaling pathways are involved in the pathology linked to PO2 oscillations. PO-2 157-160 interleukin 6 Homo sapiens 62-66 30656440-7 2019 A higher umbilical artery pO2 in the DCC group [21 (9) vs. 19 (10) mmHg, p < 0.05] was the only statistically significant difference found out of all the blood gas parameters analyzed. PO-2 26-29 DCC netrin 1 receptor Homo sapiens 37-40 30525843-4 2018 Despite its usefulness, there is limited literature on PO2 analysis in patients with obesity and insulin resistance. PO-2 55-58 insulin Homo sapiens 97-104 30525843-14 2018 Our results suggest that PO2 could be a protective factor against insulin resistance. PO-2 25-28 insulin Homo sapiens 66-73 30409512-5 2018 From ATR FTIR, the significant spectral shift is observed only for the PO2- stretching band, which correlates strongly with the polyol chain-length. PO-2 71-74 ATR serine/threonine kinase Homo sapiens 5-8 30183322-6 2018 Only cells grown in wells exposed to Po2 <=37 mmHg express the endogenous hypoxia markers hypoxia-inducible factor-1alpha and carbonic anhydrase IX. PO-2 37-40 hypoxia inducible factor 1 subunit alpha Homo sapiens 93-124 30183322-6 2018 Only cells grown in wells exposed to Po2 <=37 mmHg express the endogenous hypoxia markers hypoxia-inducible factor-1alpha and carbonic anhydrase IX. PO-2 37-40 carbonic anhydrase 9 Homo sapiens 129-150 29078168-0 2018 STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient. PO-2 85-88 signal transducer and activator of transcription 3 Homo sapiens 0-5 29600897-2 2018 We hypothesized that the coronary vascular response to Po2 and Pco2 would be attenuated in healthy men when [Formula: see text] was attenuated with beta1-adrenergic receptor blockade. PO-2 55-58 adrenoceptor beta 1 Homo sapiens 148-173 28915219-11 2018 In the control receiving intratracheal oxygen pO2 decreased from 324 to 88 mmHg after 16 minu of CPR. PO-2 46-49 cytochrome p450 oxidoreductase Sus scrofa 97-100 29078168-0 2018 STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient. PO-2 85-88 retinoid X receptor alpha Homo sapiens 6-9 29078168-0 2018 STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient. PO-2 85-88 NFE2 like bZIP transcription factor 2 Homo sapiens 10-14 30178358-9 2018 pO2 was higher in PAH (PAH 83.18 +- 1.77 vs PPH 62.75 +- 3.23 mmHg, p = 0.003; vs HPH 65.83 +- 6.94 mmHg, p = 0.036). PO-2 0-3 enolase 1 Homo sapiens 44-47 29304240-14 2018 ASC-loaded implants displayed a tendency towards increased pO2 levels from Days 7 to 14, not observed in EF implants. PO-2 59-62 PYD and CARD domain containing Homo sapiens 0-3 29304240-16 2018 Total CD34-positive endothelial area was correlated to pO2 values obtained by EPR oximetry (r = 0.6506, P = 0.0019). PO-2 55-58 CD34 molecule Homo sapiens 6-10 29138637-10 2017 PI3K/AKT was required for osteogenic differentiation, while MEK/ERK was required to repress an RUNX2 and OPN increase in low PO2. PO-2 125-128 osteopontin Ovis aries 105-108 29071321-3 2017 Using measurements under appropriately controlled gas conditions, the total rate constant is found to follow the correlation kChem/cm s-1 = 10-(1.35+-0.07) x (pO2/atm)0.72+-0.02 + 10-(3.85+-0.03) x (pH2O/atm)0.36+-0.03 where the pO2 and pH2O values of relevance are explicitly those of the final gas condition. PO-2 159-162 ATM serine/threonine kinase Homo sapiens 163-166 29071321-3 2017 Using measurements under appropriately controlled gas conditions, the total rate constant is found to follow the correlation kChem/cm s-1 = 10-(1.35+-0.07) x (pO2/atm)0.72+-0.02 + 10-(3.85+-0.03) x (pH2O/atm)0.36+-0.03 where the pO2 and pH2O values of relevance are explicitly those of the final gas condition. PO-2 159-162 ATM serine/threonine kinase Homo sapiens 204-207 29071321-3 2017 Using measurements under appropriately controlled gas conditions, the total rate constant is found to follow the correlation kChem/cm s-1 = 10-(1.35+-0.07) x (pO2/atm)0.72+-0.02 + 10-(3.85+-0.03) x (pH2O/atm)0.36+-0.03 where the pO2 and pH2O values of relevance are explicitly those of the final gas condition. PO-2 229-232 ATM serine/threonine kinase Homo sapiens 163-166 29071321-3 2017 Using measurements under appropriately controlled gas conditions, the total rate constant is found to follow the correlation kChem/cm s-1 = 10-(1.35+-0.07) x (pO2/atm)0.72+-0.02 + 10-(3.85+-0.03) x (pH2O/atm)0.36+-0.03 where the pO2 and pH2O values of relevance are explicitly those of the final gas condition. PO-2 229-232 ATM serine/threonine kinase Homo sapiens 204-207 28987998-5 2017 These goals have been successfully met, where an antibody that blocks both murine and human VEGF-A (B20.4.1.1) was found by MS 19F-MRI to produce a strong anti-vascular response and reduce viable tumor pO2 in an HM-7 xenograft model. PO-2 202-205 vascular endothelial growth factor A Homo sapiens 92-98 29082091-5 2017 Both the initial rate of pO2 change and the change in bandage pO2 at equilibration (CBP20) were found to be directly related to the metabolic oxygen consumption rate of the tissue in contact. PO-2 62-65 nuclear cap binding protein subunit 2 Homo sapiens 84-89 28214706-7 2017 Moreover, the lower pO2 was associated with lower glutathione content, the induction of p66 Shc and Mn-SOD proteins, and increased SOD activity only in HepG2. PO-2 20-23 DNA polymerase delta 3, accessory subunit Homo sapiens 88-91 28214706-7 2017 Moreover, the lower pO2 was associated with lower glutathione content, the induction of p66 Shc and Mn-SOD proteins, and increased SOD activity only in HepG2. PO-2 20-23 superoxide dismutase 2 Homo sapiens 100-106 28214706-7 2017 Moreover, the lower pO2 was associated with lower glutathione content, the induction of p66 Shc and Mn-SOD proteins, and increased SOD activity only in HepG2. PO-2 20-23 superoxide dismutase 2 Homo sapiens 103-106 28214706-10 2017 Results suggest that the long-term culturing of human hepatoma cells at a low, more physiological pO2 induces antioxidant adaptations that could be mediated by p53, and may alter the cellular response to a subsequent oxidant challenge. PO-2 98-101 tumor protein p53 Homo sapiens 160-163 28774345-7 2017 When injected into the partially hepatectomized mice, the 1% pO2 secretome most significantly increased the number of Ki67-positive cells, reduced serum levels of proinflammatory mediators (IL-6 and TNF-alpha), and reduced serum levels of liver transaminases. PO-2 61-64 interleukin 6 Mus musculus 190-194 28774345-7 2017 When injected into the partially hepatectomized mice, the 1% pO2 secretome most significantly increased the number of Ki67-positive cells, reduced serum levels of proinflammatory mediators (IL-6 and TNF-alpha), and reduced serum levels of liver transaminases. PO-2 61-64 tumor necrosis factor Mus musculus 199-208 28774345-8 2017 In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration. PO-2 82-85 thymoma viral proto-oncogene 1 Mus musculus 163-166 28774345-8 2017 In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration. PO-2 82-85 interleukin 6 Mus musculus 171-175 28774345-8 2017 In addition, analysis of the liver specimens indicated that injection with the 1% pO2 secretome maximized the expression of the intermediate molecules of the PIP3/Akt and IL-6/STAT3 signaling pathways, all of which are known to promote liver regeneration. PO-2 82-85 signal transducer and activator of transcription 3 Mus musculus 176-181 28247506-12 2017 CONCLUSIONS: Hypoxia (2%-5% oxygen or pO2 : 15.2-38.0 mm Hg) affects the viability, metabolic activity, and insulin secretion of both free and encapsulated APIs over a six-day culture period. PO-2 38-41 insulin Homo sapiens 108-115 27406649-7 2016 dose of recombinant human erythropoietin (50 IU kg-1 ) on the isocapnic HVR and HPV in seven male and seven female subjects by exposing them to hypoxia for 20 min (end-tidal PO2 ~50 mmHg) while measuring their ventilation and estimating pulmonary arterial pressure from the maximal velocity of the regurgitant jet over the tricuspid valve during systole (DeltaPmax ) with echocardiography. PO-2 174-177 erythropoietin Homo sapiens 26-40 27867481-5 2016 RIF-1 tumors were hypoxic with a baseline tissue pO2 of 6.2-8.3 mmHg in mice breathing 30% O2. PO-2 49-52 replication timing regulatory factor 1 Mus musculus 0-5 27671638-5 2016 Our calculations demonstrate that anaerobic oxidation of CH4 coupled to SO42- reduction is a highly effective obstacle to CH4 accumulation in the atmosphere, possibly limiting atmospheric pCH4 to less than 10 ppm by volume for the second half of Earth history regardless of atmospheric pO2 If recent pO2 constraints from Cr isotopes are correct, we predict that reduced UV shielding by O3 should further limit pCH4 to very low levels similar to those seen today. PO-2 300-303 tRNA splicing endonuclease subunit 54 Homo sapiens 188-192 27245780-7 2016 In Mycobacterium tuberculosis (M.tb)-infected human macrophages, hypoxia (1% pO2) upregulated MMP-1 gene expression 170-fold, driving secretion and caseinolytic activity. PO-2 77-80 matrix metallopeptidase 1 Homo sapiens 94-99 27426098-4 2016 Exogenous angiotensin-II reduced renal cortical tissue PO2 more than equi-pressor doses of phenylephrine, probably because it reduced renal oxygen delivery more than did phenylephrine. PO-2 55-58 angiotensinogen Rattus norvegicus 10-24 27426098-7 2016 ABSTRACT: We hypothesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the progression of chronic kidney disease. PO-2 129-132 angiotensinogen Rattus norvegicus 61-75 27426098-7 2016 ABSTRACT: We hypothesised that both exogenous and endogenous angiotensin-II (AngII) can decrease the partial pressure of oxygen (PO2) in the renal cortex of unrestrained rats, which might in turn contribute to the progression of chronic kidney disease. PO-2 129-132 angiotensinogen Rattus norvegicus 77-82 27426098-10 2016 In conscious rats, renal cortical PO2 was dose-dependently reduced by intravenous AngII. PO-2 34-37 angiotensinogen Rattus norvegicus 82-87 27118044-7 2016 Although there is no evidence that AML pathophysiology is related to hypoxia, leukemic blasts still show several distinct biological features when exposed to reduced pO2: they down- or upregulate membrane receptors such as CXCR4 or FLT3, activate or inhibit intracellular signaling pathways such as PI3K, and specifically secrete cytokines (IL-8). PO-2 166-169 C-X-C motif chemokine receptor 4 Homo sapiens 223-228 27118044-7 2016 Although there is no evidence that AML pathophysiology is related to hypoxia, leukemic blasts still show several distinct biological features when exposed to reduced pO2: they down- or upregulate membrane receptors such as CXCR4 or FLT3, activate or inhibit intracellular signaling pathways such as PI3K, and specifically secrete cytokines (IL-8). PO-2 166-169 fms related receptor tyrosine kinase 3 Homo sapiens 232-236 27118044-7 2016 Although there is no evidence that AML pathophysiology is related to hypoxia, leukemic blasts still show several distinct biological features when exposed to reduced pO2: they down- or upregulate membrane receptors such as CXCR4 or FLT3, activate or inhibit intracellular signaling pathways such as PI3K, and specifically secrete cytokines (IL-8). PO-2 166-169 C-X-C motif chemokine ligand 8 Homo sapiens 341-345 26927670-2 2016 Decreases of renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) induction of EPO in peritubular interstitial fibroblast-like cells, which serve as the cellular site of EPO synthesis in the kidney. PO-2 19-22 erythropoietin Mus musculus 97-100 26927670-2 2016 Decreases of renal pO2 promote hypoxia-inducible factor 2-mediated (HIF-2-mediated) induction of EPO in peritubular interstitial fibroblast-like cells, which serve as the cellular site of EPO synthesis in the kidney. PO-2 19-22 erythropoietin Mus musculus 188-191 26927670-6 2016 Moreover, suppression of renal EPO production was associated with increased glucose uptake, enhanced glycolysis, reduced mitochondrial mass, diminished O2 consumption, and elevated renal tissue pO2. PO-2 194-197 erythropoietin Mus musculus 31-34 26863525-2 2016 Syncytiotrophoblast hCG secretion is modulated by the partial pressure of oxygen (pO2), reactive oxygen species (ROS) and potassium (K+) channels. PO-2 82-85 chorionic gonadotropin subunit beta 5 Homo sapiens 20-23 26863525-9 2016 4-AP/TEA inhibited hCG secretion to a greater extent at 21% than 6% and 1% pO2, and reduced 86Rb efflux at 21% but not 6% pO2. PO-2 75-78 chorionic gonadotropin subunit beta 5 Homo sapiens 19-22 26863525-3 2016 Here we test the hypothesis that K+ channels mediate the effects of pO2 and ROS on hCG secretion. PO-2 68-71 chorionic gonadotropin subunit beta 5 Homo sapiens 83-86 26863525-10 2016 LDH release and tissue LDH/hCG were similar in 6%, 21% and 1% pO2 and unaffected by 4-AP/TEA. PO-2 62-65 chorionic gonadotropin subunit beta 5 Homo sapiens 27-30 26863525-8 2016 hCG secretion and 86Rb efflux were significantly greater in explants maintained in 21% pO2 than normoxia. PO-2 87-90 chorionic gonadotropin subunit beta 5 Homo sapiens 0-3 26863525-13 2016 ROS effects on both hCG secretion and 86Rb efflux are pO2-dependent but causal links between the two remain to be established. PO-2 54-57 chorionic gonadotropin subunit beta 5 Homo sapiens 20-23 26529660-9 2016 Our data demonstrate that selective temporal blockade of Ang-2 function following hemorrhagic shock priming significantly improved PO2/FIO2, decreased lung protein leak and indices of inflammation, and improved 10-day survival in our murine model for the development iARDS. PO-2 131-134 angiogenin, ribonuclease A family, member 2 Mus musculus 57-62 25765253-7 2016 RESULTS: Administration of CA4 induced a significant decrease in lipids R1 (P = 0.0273) on pooled tumor models and a reduction in tumor pO2 measured by EPR oximetry. PO-2 136-139 carbonic anhydrase 4 Mus musculus 27-30 26695452-0 2016 Profound Understanding of Effect of Transition Metal Dopant, Sintering Temperature, and pO2 on the Electrical and Optical Properties of Proton Conducting BaCe0.9Sm0.1O3-delta. PO-2 88-91 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Homo sapiens 154-174 26423578-0 2015 Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels. PO-2 0-3 thymoma viral proto-oncogene 1 Mus musculus 70-73 26744210-5 2016 RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +- 1.2 (0 L min(-1)); 18.5 +- 1.5 (5 L min(-1)); 21.7 +- 1.7 (10 L min(-1)); 24.0 +- 2.3 (15 L min(-1)). PO-2 18-21 CD59 molecule (CD59 blood group) Homo sapiens 101-107 26744210-5 2016 RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +- 1.2 (0 L min(-1)); 18.5 +- 1.5 (5 L min(-1)); 21.7 +- 1.7 (10 L min(-1)); 24.0 +- 2.3 (15 L min(-1)). PO-2 18-21 CD59 molecule (CD59 blood group) Homo sapiens 128-134 26744210-5 2016 RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +- 1.2 (0 L min(-1)); 18.5 +- 1.5 (5 L min(-1)); 21.7 +- 1.7 (10 L min(-1)); 24.0 +- 2.3 (15 L min(-1)). PO-2 18-21 CD59 molecule (CD59 blood group) Homo sapiens 128-134 26744210-5 2016 RESULTS: Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 +- 1.2 (0 L min(-1)); 18.5 +- 1.5 (5 L min(-1)); 21.7 +- 1.7 (10 L min(-1)); 24.0 +- 2.3 (15 L min(-1)). PO-2 18-21 CD59 molecule (CD59 blood group) Homo sapiens 128-134 27882073-12 2016 PO2 was significantly increased after ALP-CPR (45.15 to 60.68, P < 0.001), but it was not changed after STD-CPR. PO-2 0-3 cytochrome p450 oxidoreductase Homo sapiens 42-45 27882073-13 2016 PO2 after CPR was significantly higher in the ALP-CPR group (60.68 versus 44.47, P < 0.001). PO-2 0-3 cytochrome p450 oxidoreductase Homo sapiens 10-13 27882073-13 2016 PO2 after CPR was significantly higher in the ALP-CPR group (60.68 versus 44.47, P < 0.001). PO-2 0-3 cytochrome p450 oxidoreductase Homo sapiens 50-53 27974949-11 2016 The levels of pO2 were positively related with the gray values of Ki67 and negatively related with the values of HIF-1 alpha and CK20 (P < 0.05). PO-2 14-17 hypoxia inducible factor 1 subunit alpha Homo sapiens 113-124 27974949-11 2016 The levels of pO2 were positively related with the gray values of Ki67 and negatively related with the values of HIF-1 alpha and CK20 (P < 0.05). PO-2 14-17 keratin 20 Homo sapiens 129-133 26423578-0 2015 Po2 cycling protects diaphragm function during reoxygenation via ROS, Akt, ERK, and mitochondrial channels. PO-2 0-3 mitogen-activated protein kinase 1 Mus musculus 75-78 26423578-4 2015 We hypothesize that Po2 cycling effectively increases muscle fatigue resistance through reactive oxygen species (ROS), protein kinase B (Akt), extracellular signal-regulated kinase (ERK), and certain mitochondrial channels during reoxygenation. PO-2 20-23 thymoma viral proto-oncogene 1 Mus musculus 137-140 26423578-4 2015 We hypothesize that Po2 cycling effectively increases muscle fatigue resistance through reactive oxygen species (ROS), protein kinase B (Akt), extracellular signal-regulated kinase (ERK), and certain mitochondrial channels during reoxygenation. PO-2 20-23 mitogen-activated protein kinase 1 Mus musculus 143-180 26423578-4 2015 We hypothesize that Po2 cycling effectively increases muscle fatigue resistance through reactive oxygen species (ROS), protein kinase B (Akt), extracellular signal-regulated kinase (ERK), and certain mitochondrial channels during reoxygenation. PO-2 20-23 mitogen-activated protein kinase 1 Mus musculus 182-185 26423578-10 2015 Thus we have identified a unique signaling pathway that may involve ROS, Akt, ERK, and mitochondrial channels responsible for Po2 cycling protection during reoxygenation conditions in the diaphragm. PO-2 126-129 thymoma viral proto-oncogene 1 Mus musculus 73-76 26423578-10 2015 Thus we have identified a unique signaling pathway that may involve ROS, Akt, ERK, and mitochondrial channels responsible for Po2 cycling protection during reoxygenation conditions in the diaphragm. PO-2 126-129 mitogen-activated protein kinase 1 Mus musculus 78-81 25422368-4 2015 The underlying mechanism is suppression of hepatic erythropoietin expression associated with the downregulation of tissue hypoxia markers, suggesting increased pO2. PO-2 160-163 erythropoietin Rattus norvegicus 51-65 26742253-2 2015 Expression of GAP-43 in the CB of rats under different atmospheric pressures and oxygen partial pressure (PO2) conditions was investigated. PO-2 106-109 growth associated protein 43 Rattus norvegicus 14-20 26164068-10 2015 CONCLUSIONS: This study suggests that the bias of cultured blood CD34+ cells toward megakaryocyte and erythrocyte progenitor cells can be reduced by use of 8% pO2. PO-2 159-162 CD34 molecule Homo sapiens 65-69 25542981-11 2015 Infusion of ET-1 or ET-1+ETB receptor antagonist reduced rCBF to ~25% and pO2 to ~10% for about 1.5h, whereas selective ETB agonist, ET-1+ETA antagonist and the PBS vehicle had only negligible effect on the rCBF and pO2 levels. PO-2 74-77 endothelin 1 Rattus norvegicus 12-37 25666432-6 2015 The ability of the PSs to initiate Type I photoreactions was tested by exposing PS-treated U87 cells to light under hypoxic conditions (pO2 < 0.5%), which resulted in a complete loss of the PDT effect. PO-2 136-139 small nucleolar RNA, C/D box 87 Mus musculus 91-94 26030353-11 2015 However, decreasing citrate synthase may be essential to preserve local PO2, minimising regions of hypoxia and hence maximising the area of myocardium able to preserve cardiac output following maternal hypoxia. PO-2 72-75 citrate synthase Rattus norvegicus 20-36 25804925-3 2015 This study investigates whether increasing cerebral tissue PO2 through normobaric hyperoxia (NBO) treatment will slow the progression of BBB damage and, thus, improve the outcome of delayed tPA treatment after cerebral ischemia. PO-2 59-62 plasminogen activator, tissue type Rattus norvegicus 190-193 25657207-6 2015 In response to sea level PO2 and hypoxia, mice and rats had similar changes of ventilation, but metabolic rate decreased much more in hypoxia in mice, while pO2 ,sat remained higher in mice. PO-2 25-28 sepia Mus musculus 15-18 25657207-6 2015 In response to sea level PO2 and hypoxia, mice and rats had similar changes of ventilation, but metabolic rate decreased much more in hypoxia in mice, while pO2 ,sat remained higher in mice. PO-2 157-160 sepia Mus musculus 15-18