PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33826085-9	2021	CONCLUSION: Following repeat AF ablation, ER is strongly associated with LR, cardioversion post BP, and repeat ablation.	Lawrencium	73-75	epiregulin	Homo sapiens	42-44
8079372-1	1994	Microcystin-LR (MCYST-LR) was found to be a very potent protein-phosphatase 2A (PP2A) inhibitor at an ID50 as low as 0.1 nM.	Lawrencium	11-14	protein phosphatase 2 phosphatase activator	Homo sapiens	56-78
8079372-1	1994	Microcystin-LR (MCYST-LR) was found to be a very potent protein-phosphatase 2A (PP2A) inhibitor at an ID50 as low as 0.1 nM.	Lawrencium	11-14	protein phosphatase 2 phosphatase activator	Homo sapiens	80-84
1724618-3	1990	The cyclic peptide microcystin-LR (MLR) and the depsipeptides, valinomycin (VLM) and enniatin-B (ENB), bind to CaM and inhibit PDE activity.	Lawrencium	30-33	calmodulin 1	Homo sapiens	111-114
33823188-3	2021	LR-3T-5D was more effective for cell viability, viable cell recovery ratio, annexin V-positive ratio, and colony-forming capacity as a vehicle solution for cryopreservation with 10% Me2SO than LR.	Lawrencium	0-2	annexin A5	Homo sapiens	76-85
33823188-7	2021	LR-3T-5D was superior to LR-3T as a replacement solution in terms of viability and annexin V positivity.	Lawrencium	0-2	annexin A5	Homo sapiens	83-92
33798882-12	2021	These results suggest that ROS-mediated GCN2/eIF2alpha activation contributes partially to MC-LR-caused downregulation of steroidogenic proteins and synthases.	Lawrencium	93-96	eukaryotic translation initiation factor 2 alpha kinase 4	Mus musculus	40-44
33798882-12	2021	These results suggest that ROS-mediated GCN2/eIF2alpha activation contributes partially to MC-LR-caused downregulation of steroidogenic proteins and synthases.	Lawrencium	93-96	eukaryotic translation initiation factor 2A	Mus musculus	45-54
34566654-3	2021	Significant reductions in transepithelial electrical resistance, occludin, and zonula occludens-1(ZO-1) levels were detected in the MC-LR-treated TM4 cells, and quercetin attenuated these effects.	Lawrencium	135-137	occludin	Mus musculus	65-73
34841679-8	2021	Among them, miltefosine transcriptionally inhibited checkpoint kinase 1 (CHEK1), indicating that LR integrity is essential for CHEK1 expression regulation.	Lawrencium	97-99	checkpoint kinase 1	Homo sapiens	52-71
34841679-8	2021	Among them, miltefosine transcriptionally inhibited checkpoint kinase 1 (CHEK1), indicating that LR integrity is essential for CHEK1 expression regulation.	Lawrencium	97-99	checkpoint kinase 1	Homo sapiens	73-78
34841679-8	2021	Among them, miltefosine transcriptionally inhibited checkpoint kinase 1 (CHEK1), indicating that LR integrity is essential for CHEK1 expression regulation.	Lawrencium	97-99	checkpoint kinase 1	Homo sapiens	127-132
34841679-11	2021	CONCLUSION: Our findings underscore the therapeutic potential of LR-targeting APLs for CRC treatment that overcomes the therapy-resistant phenotype of CSCs, highlighting the importance of the LR/CHEK1 axis as a novel mechanism of APLs.	Lawrencium	65-67	checkpoint kinase 1	Homo sapiens	195-200
34566654-3	2021	Significant reductions in transepithelial electrical resistance, occludin, and zonula occludens-1(ZO-1) levels were detected in the MC-LR-treated TM4 cells, and quercetin attenuated these effects.	Lawrencium	135-137	tight junction protein 1	Mus musculus	98-102
34590607-12	2021	Positive margins after surgery, extracapsular node invasion, and HER2-enriched/triple-negative tumors were linked with significantly worse LR-free survival.	Lawrencium	139-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
35196614-13	2022	The PPVs for HCCs in reclassified LR-3, LR-4 and LR-5 were 27.3% (95% CI: 9.7-56.6), 41.7% (95% CI: 26.2-69.0) and 94.2% (95% CI: 89.3-97.0), respectively, which decreased the incidences of HCCs in CT/MRI LR-3 and LR-4.	Lawrencium	40-42	holocytochrome c synthase	Homo sapiens	13-17
34405373-7	2021	The fold-regulation values for the following genes for LA-5 and LR-32 were, respectively, IL-12B (431.94 and 33.30), IL-1Beta (76.73 and 17.14), TNF-alpha (94.63 and 2.49), CXCL-8 (89.59 and 4.18), and TLR-2 (49.68 and 3.40).	Lawrencium	64-66	interleukin 1 beta	Homo sapiens	117-125
34242037-1	2021	Experiments were performed at the Lawrence Berkeley National Laboratory 88-Inch Cyclotron facility to investigate the electron-transfer reduction reaction of dipositive Lr (Z = 103) with O2 gas.	Lawrencium	169-171	gastrin	Homo sapiens	190-193
34440171-7	2021	A high expression of NR1D2 appeared as an independent prognostic factor of LR development after disease diagnosis.	Lawrencium	75-77	nuclear receptor subfamily 1 group D member 2	Homo sapiens	21-26
34222402-6	2021	The results at T1 showed that 9% (2/22) of the horses in the control group were sound compared to 59% (25/46) and 84% (21/25) in the LR-PRP and BMAC groups, respectively.	Lawrencium	133-135	prion protein	Equus caballus	136-139
34222402-7	2021	Additionally, ultrasound scores at T1 in the BMAC and LR-PRP groups were improved in comparison with the control group (p = 0.02).	Lawrencium	54-56	prion protein	Equus caballus	57-60
34222402-9	2021	At T3, a significantly higher percentage of horses in the LR-PRP (43%) and BMAC (72%) group were sound when compared to the control (4.6%) group (p = 0.02).	Lawrencium	58-60	prion protein	Equus caballus	61-64
35445513-6	2022	For LR-4 observations, the 1-year, 3-year, and 5-year cumulative incidences of progression to a malignant category were 18.5% (95% confidence interval, 6.6-35.2%), 43.0% (23.1-61.5%), and 52.5% (25.9-73.5%), which were significantly higher than those of LR-2 and LR-3 (P<0.001).	Lawrencium	4-6	LDL receptor related protein 5	Homo sapiens	263-267
35445513-7	2022	For LR-3, the 1-year, 3-year, and 5-year cumulative incidences of progression to LR-4 or higher were 4.1% (1.1-10.4%), 13.9% (6.7-23.6%), and 23.1% (12.7-35.4%), which were significantly higher than that of LR-2 (P=0.009).	Lawrencium	81-83	LDL receptor related protein 5	Homo sapiens	4-8
35445513-7	2022	For LR-3, the 1-year, 3-year, and 5-year cumulative incidences of progression to LR-4 or higher were 4.1% (1.1-10.4%), 13.9% (6.7-23.6%), and 23.1% (12.7-35.4%), which were significantly higher than that of LR-2 (P=0.009).	Lawrencium	207-209	LDL receptor related protein 5	Homo sapiens	4-8
35168133-8	2022	The relative abundance of Sphingomonadaceae possessing the degradation capability for MCs increased in T1, which contributed to the higher MC-LR removal efficiency compared to CK and T2.	Lawrencium	142-144	cytidine/uridine monophosphate kinase 1	Homo sapiens	176-178
35196614-13	2022	The PPVs for HCCs in reclassified LR-3, LR-4 and LR-5 were 27.3% (95% CI: 9.7-56.6), 41.7% (95% CI: 26.2-69.0) and 94.2% (95% CI: 89.3-97.0), respectively, which decreased the incidences of HCCs in CT/MRI LR-3 and LR-4.	Lawrencium	49-51	holocytochrome c synthase	Homo sapiens	13-17
35196614-13	2022	The PPVs for HCCs in reclassified LR-3, LR-4 and LR-5 were 27.3% (95% CI: 9.7-56.6), 41.7% (95% CI: 26.2-69.0) and 94.2% (95% CI: 89.3-97.0), respectively, which decreased the incidences of HCCs in CT/MRI LR-3 and LR-4.	Lawrencium	205-207	holocytochrome c synthase	Homo sapiens	13-17
35196614-13	2022	The PPVs for HCCs in reclassified LR-3, LR-4 and LR-5 were 27.3% (95% CI: 9.7-56.6), 41.7% (95% CI: 26.2-69.0) and 94.2% (95% CI: 89.3-97.0), respectively, which decreased the incidences of HCCs in CT/MRI LR-3 and LR-4.	Lawrencium	214-216	holocytochrome c synthase	Homo sapiens	13-17
35571669-7	2022	Women are more susceptible to LR, and R1/R2 resection margin is significantly correlated with a high rate of LR.	Lawrencium	109-111	CD1b molecule	Homo sapiens	38-43
34643108-10	2022	For LR-3 observations, progression to LR-4 was 22.2% (95% CI 9.6%-43.8%) and LR-5 was 11.1% (95% CI 3.0%-28.4%) for both readers.	Lawrencium	38-40	LDL receptor related protein 5	Homo sapiens	4-8
35257633-11	2022	Enzyme-linked immunoassay results showed that the concentrations of IL-1beta and TNF-alpha in the LR-PRP group were significantly higher than those in the other groups at 4 and 8 weeks, while the concentrations of IL-1beta and TNF-alpha in the LP-PRP group were significantly lower than those in the control group.	Lawrencium	98-100	interleukin 1 alpha	Mus musculus	68-76
35257633-11	2022	Enzyme-linked immunoassay results showed that the concentrations of IL-1beta and TNF-alpha in the LR-PRP group were significantly higher than those in the other groups at 4 and 8 weeks, while the concentrations of IL-1beta and TNF-alpha in the LP-PRP group were significantly lower than those in the control group.	Lawrencium	98-100	tumor necrosis factor	Mus musculus	81-90
35257633-11	2022	Enzyme-linked immunoassay results showed that the concentrations of IL-1beta and TNF-alpha in the LR-PRP group were significantly higher than those in the other groups at 4 and 8 weeks, while the concentrations of IL-1beta and TNF-alpha in the LP-PRP group were significantly lower than those in the control group.	Lawrencium	98-100	interleukin 1 alpha	Mus musculus	214-222
35257633-11	2022	Enzyme-linked immunoassay results showed that the concentrations of IL-1beta and TNF-alpha in the LR-PRP group were significantly higher than those in the other groups at 4 and 8 weeks, while the concentrations of IL-1beta and TNF-alpha in the LP-PRP group were significantly lower than those in the control group.	Lawrencium	98-100	tumor necrosis factor	Mus musculus	227-236
35103547-11	2022	No severe adverse events were described in either group, although 15 mild adverse events (knee pain or swelling) were reported: 12.2% for LR-PRP and 4.7% for LP-PRP (P = .101).	Lawrencium	138-140	complement component 4 binding protein alpha	Homo sapiens	141-144
33644963-2	2021	Current research suggests both percutaneous needle tenotomy (PNT) and leukocyte-rich platelet-rich plasma (LR-PRP) may be effective treatments for chronic tendinosis, but no studies have assessed the effectiveness of PNT alone vs. PNT with intratendinous LR-PRP for multiple tendon types in a single study.	Lawrencium	107-109	prion protein	Homo sapiens	110-113
3342718-8	1988	The GER incidence for single maneuvers was: AC, 0%; LR, 0%; RS, 19%; and BD, 24%.	Lawrencium	52-54	GER	Homo sapiens	4-7
33917959-3	2021	The chromatin remodeling protein PICKLE (PKL) negatively regulates auxin-mediated LR formation through a mechanism that is not yet known.	Lawrencium	82-84	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	33-39
33917959-3	2021	The chromatin remodeling protein PICKLE (PKL) negatively regulates auxin-mediated LR formation through a mechanism that is not yet known.	Lawrencium	82-84	chromatin remodeling factor CHD3 (PICKLE)	Arabidopsis thaliana	41-44
33869175-6	2021	We conclude that Pkd2 reduction leads to LR defects that cannot be assigned exclusively to its putative role in mediating mechanosensation because indirectly, by modifying cell shape or decreasing cilia length, Pkd2 deficit affects LR flow dynamics.	Lawrencium	41-43	polycystin 2, transient receptor potential cation channel	Homo sapiens	17-21
33869175-6	2021	We conclude that Pkd2 reduction leads to LR defects that cannot be assigned exclusively to its putative role in mediating mechanosensation because indirectly, by modifying cell shape or decreasing cilia length, Pkd2 deficit affects LR flow dynamics.	Lawrencium	232-234	polycystin 2, transient receptor potential cation channel	Homo sapiens	17-21
33869175-6	2021	We conclude that Pkd2 reduction leads to LR defects that cannot be assigned exclusively to its putative role in mediating mechanosensation because indirectly, by modifying cell shape or decreasing cilia length, Pkd2 deficit affects LR flow dynamics.	Lawrencium	232-234	polycystin 2, transient receptor potential cation channel	Homo sapiens	211-215
6109537-2	1980	A dose-dependent inhibition of conditioned avoidance response (CAR) was documented in trained rats after acute treatment with several neuroleptics: haloperidol, chlorpromazine (CPZ), fluanisone and 4-p-fluorophenyl-5-N(N"-o-methoxyphenyl)piperazinoethyl-4-oxazolin-2-one (zoloperone, LR 511).	Lawrencium	284-286	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	63-66
6109537-4	1980	Daily treatment with LR 511 or haloperidol for 7-16 days did not cause the appearance of tolerance in young and adult rats, on the contrary, made in evidence a stronger effect on CAR and on UER.	Lawrencium	21-23	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	179-182
34005835-7	2021	Moreover, LR increased the abundance of the genus Bifidobacterium, which generated bile salt hydrolase, and thus presumably enhanced bile acid (BA) deconjugation and increased fecal BA excretion.	Lawrencium	10-12	glucosidase beta 2	Mus musculus	133-142
33410399-5	2021	Here we report that RGS14 encoding LR or RQ profoundly impacts protein functions in hippocampal neurons.	Lawrencium	35-37	regulator of G protein signaling 14	Homo sapiens	20-25
33258804-4	2021	Trem1 gene deletion (Apoe-/-Trem1-/-), as well as TREM-1 pharmacological blockade with LR-12 peptide limited both AAA development and severity.	Lawrencium	87-89	triggering receptor expressed on myeloid cells 1	Mus musculus	50-56
33154617-10	2020	The model equation for LR insertion: LR (mm) = 5.72 + 0.048 (AXL in mm) with an R = 0.438, R2= 0.192, F=12.116, P<0.001.	Lawrencium	23-25	AXL receptor tyrosine kinase	Homo sapiens	61-64
33154617-10	2020	The model equation for LR insertion: LR (mm) = 5.72 + 0.048 (AXL in mm) with an R = 0.438, R2= 0.192, F=12.116, P<0.001.	Lawrencium	37-39	AXL receptor tyrosine kinase	Homo sapiens	61-64
32478427-10	2020	CONCLUSION: The combined results indicate that Lr-0601 modulated the balance of Th1/Th2 and Treg/Th17 in OVA-sensitized mice, which was associated with the regulation of immune-related transcription factors and gut microbiota.	Lawrencium	47-49	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	105-108
32656780-6	2020	On the contrary, constitutive overexpression of XTH19 or XTH23 caused increased LR densities.	Lawrencium	80-82	xyloglucan endotransglucosylase/hydrolase 19	Arabidopsis thaliana	48-53
32656780-6	2020	On the contrary, constitutive overexpression of XTH19 or XTH23 caused increased LR densities.	Lawrencium	80-82	xyloglucan endotransglycosylase 6	Arabidopsis thaliana	57-62
32311947-10	2020	Comprehensive comparison of 2 circulating biomarkers using back-calculated likelihood ratio (LR) demonstrated that serum KL-6 corresponded to a higher LR+ and a lower LR- in comparison to serum SP-D, as well as in SSc-ILD.	Lawrencium	93-95	mucin 1, cell surface associated	Homo sapiens	121-125
32666684-11	2020	The results showed that the elderly recipients had much higher levels of TNF-alpha, IL-6, IL-1beta, and IL-18 post-transplantation, indicating increased NLRP3 activation in lR-stressed livers of elderly recipients.	Lawrencium	173-175	interleukin 1 alpha	Mus musculus	90-98
32666684-11	2020	The results showed that the elderly recipients had much higher levels of TNF-alpha, IL-6, IL-1beta, and IL-18 post-transplantation, indicating increased NLRP3 activation in lR-stressed livers of elderly recipients.	Lawrencium	173-175	interleukin 18	Mus musculus	104-109
32666684-11	2020	The results showed that the elderly recipients had much higher levels of TNF-alpha, IL-6, IL-1beta, and IL-18 post-transplantation, indicating increased NLRP3 activation in lR-stressed livers of elderly recipients.	Lawrencium	173-175	NLR family, pyrin domain containing 3	Mus musculus	153-158
32519886-12	2020	Structural changes in the synovial tissue were significantly inhibited in the pure-PRP group compared with the control group after both 5 and 14 days (P < .001 and P = .025, respectively), whereas no significant difference was found between the control, LP-PRP, and LR-PRP groups.	Lawrencium	266-268	proline rich protein 2-like 1	Rattus norvegicus	83-86
32134682-8	2020	RESULTS: The Lr-PRP group had a lower T2 signal intensity (P = .0377) and smaller diameter (P = .0193) and cross-sectional area (P = .0194) than the Lp-PRP group on MRI.	Lawrencium	13-15	complement component 4 binding protein alpha	Homo sapiens	16-19
32134682-11	2020	Considering TEM and biomechanical testing, the Lr-PRP group demonstrated more mature collagen fibers (P < .0001), a larger fiber diameter (P = .0005), a higher failure load (P = .00417), and higher tensile stress (P < .0001) than the Lp-PRP group.	Lawrencium	47-49	complement component 4 binding protein alpha	Homo sapiens	50-53
32683095-6	2020	Among LT patients with pre-transplant imaging at our institution (n = 42/72), 69% of the NOD1 were LR-5, 21% LR-4 and 10% LR-3.	Lawrencium	99-101	nucleotide binding oligomerization domain containing 1	Homo sapiens	89-93
31840415-2	2020	The influence of different stages of tendinopathy on effects of leukocyte-rich platelet-rich plasma (Lr-PRP) has not been elucidated.	Lawrencium	101-103	major prion protein	Oryctolagus cuniculus	104-107
31840415-3	2020	The aim of this study is to investigate the optimal time point for delivery of Lr-PRP on tendinopathy.	Lawrencium	79-81	major prion protein	Oryctolagus cuniculus	82-85
31840415-5	2020	Then after collagenase induction, following treatments were applied randomly on the lesion: (1) 200 mul of Lr-PRP at one week (PRP-1 group), (2) 200 mul of saline at one week (Saline-1 group), (3) 200 mul of Lr-PRP at four week (PRP-2 group), (4) 200 mul of saline at four week (Saline-2 group).	Lawrencium	107-109	major prion protein	Oryctolagus cuniculus	110-113
31840415-13	2020	In conclusion, intra-tendon delivery of Lr-PRP at early stage showed beneficial effect for repair of tendinopathy, but not at late stage.	Lawrencium	40-42	major prion protein	Oryctolagus cuniculus	43-46
31403703-3	2020	Here, we report that SHI-RELATED SEQUENCE5 (SRS5) is an intrinsic negative regulator of LR formation and that auxin signalling abolishes this inhibitory effect of SRS5.	Lawrencium	88-90	SHI-related sequence 5	Arabidopsis thaliana	44-48
31403703-3	2020	Here, we report that SHI-RELATED SEQUENCE5 (SRS5) is an intrinsic negative regulator of LR formation and that auxin signalling abolishes this inhibitory effect of SRS5.	Lawrencium	88-90	SHI-related sequence 5	Arabidopsis thaliana	163-167
31403703-5	2020	SRS5 inhibited LR formation by directly downregulating the expression of LATERAL ORGAN BOUNDARIES-DOMAIN 16 (LBD16) and LBD29.	Lawrencium	15-17	SHI-related sequence 5	Arabidopsis thaliana	0-4
31403703-3	2020	Here, we report that SHI-RELATED SEQUENCE5 (SRS5) is an intrinsic negative regulator of LR formation and that auxin signalling abolishes this inhibitory effect of SRS5.	Lawrencium	88-90	SHI-related sequence 5	Arabidopsis thaliana	21-42
31403703-5	2020	SRS5 inhibited LR formation by directly downregulating the expression of LATERAL ORGAN BOUNDARIES-DOMAIN 16 (LBD16) and LBD29.	Lawrencium	15-17	lateral organ boundaries-domain 16	Arabidopsis thaliana	73-107
31403703-5	2020	SRS5 inhibited LR formation by directly downregulating the expression of LATERAL ORGAN BOUNDARIES-DOMAIN 16 (LBD16) and LBD29.	Lawrencium	15-17	lateral organ boundaries-domain 16	Arabidopsis thaliana	109-114
31403703-8	2020	Taken together, our data reveal that SRS5 negatively regulates LR formation by repressing the expression of LBD16 and LBD29 and that auxin releases this inhibitory effect through ARF7 and ARF19.	Lawrencium	63-65	SHI-related sequence 5	Arabidopsis thaliana	37-41
31403703-8	2020	Taken together, our data reveal that SRS5 negatively regulates LR formation by repressing the expression of LBD16 and LBD29 and that auxin releases this inhibitory effect through ARF7 and ARF19.	Lawrencium	63-65	lateral organ boundaries-domain 16	Arabidopsis thaliana	108-113
31403703-8	2020	Taken together, our data reveal that SRS5 negatively regulates LR formation by repressing the expression of LBD16 and LBD29 and that auxin releases this inhibitory effect through ARF7 and ARF19.	Lawrencium	63-65	lateral organ boundaries-domain 29	Arabidopsis thaliana	118-123
30708114-16	2019	Consistent with physicians" expectations, 7 of 13 physical examination items strongly favored hip OA over LSS: limited weight-bearing on painful leg when standing (+LR=10); observed limp (+LR=9); and painful and restricted range-of-motion with any of five hip maneuvers (+LR range 21-99).	Lawrencium	165-167	hedgehog interacting protein	Homo sapiens	94-97
30125143-6	2018	The RNAi-induced downregulation and overexpression of LBD14 indicated that LBD14 promotes LR formation.	Lawrencium	90-92	LOB domain-containing protein 14	Arabidopsis thaliana	54-59
30025486-7	2018	Similarly, PEI (OR 4.29, CrI 1.18, 18.35, p &lt; 0.01) yielded more LR than SR.	Lawrencium	68-70	EP300 interacting inhibitor of differentiation 1	Homo sapiens	25-30
31036560-4	2019	We show that psychosine, the GSL that accumulates in Krabbe disease, leads to a dose-dependent LR-mediated inhibition of this pathway by uncoupling IGF-1 receptor phosphorylation from downstream Akt activation.	Lawrencium	95-97	AKT serine/threonine kinase 1	Homo sapiens	195-198
30430930-10	2018	In summary, data indicate that the MC-LR-induced alterations in lncRNA may be associated with hepatotoxicity and that upregulation of LINC00847, MIR22HG and LNC_00027 may play important roles in the observed MC-mediated liver damage.	Lawrencium	38-40	long intergenic non-protein coding RNA 847	Homo sapiens	134-143
30430930-10	2018	In summary, data indicate that the MC-LR-induced alterations in lncRNA may be associated with hepatotoxicity and that upregulation of LINC00847, MIR22HG and LNC_00027 may play important roles in the observed MC-mediated liver damage.	Lawrencium	38-40	MIR22 host gene	Homo sapiens	145-152
30125143-6	2018	The RNAi-induced downregulation and overexpression of LBD14 indicated that LBD14 promotes LR formation.	Lawrencium	90-92	LOB domain-containing protein 14	Arabidopsis thaliana	75-80
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	146-151
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	153-158
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	160-165
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	167-172
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	NRAS proto-oncogene, GTPase	Homo sapiens	178-183
28062358-3	2017	The results of qPCR and Western blotting showed that MC-LR-exposure at non- or sub-cytotoxic concentrations promoted the expressions of oncogenes c-fos, c-jun, c-myc, c-met, and N-ras while suppressed tumor-suppressor gene PTEN in HepG2 cells at both transcription and protein levels.	Lawrencium	56-58	phosphatase and tensin homolog	Homo sapiens	223-227
27608041-0	2016	miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice.	Lawrencium	35-37	microRNA 541	Mus musculus	0-7
27525707-13	2016	CONCLUSIONS: The majority of patients with NF2 implanted with an ABI find the device a useful aid to communication in conjunction with LR and in recognizing common environmental sounds.	Lawrencium	135-137	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	43-46
27608041-0	2016	miR-541 Contributes to Microcystin-LR-Induced Reproductive Toxicity through Regulating the Expression of p15 in Mice.	Lawrencium	35-37	cyclin dependent kinase inhibitor 2B	Mus musculus	105-108
22386762-5	2012	The embryo-transfer cancellation per patient was significantly lower in the LR-Accu-Vit group (9.1%) than the LR-fresh group (34.0%).	Lawrencium	76-78	vitrin	Homo sapiens	84-87
26493400-3	2015	We recently identified a mutation affecting NEK2, a member of the NIMA-like serine-threonine kinase family, in a patient with congenital heart disease associated with abnormal LR development.	Lawrencium	176-178	NIMA related kinase 2	Homo sapiens	44-48
26395499-0	2015	Intracellular Calcium Plays a Critical Role in the Microcystin-LR-Elicited Neurotoxicity Through PLC/IP3 Pathway.	Lawrencium	62-65	heparan sulfate proteoglycan 2	Homo sapiens	97-100
25855457-7	2015	Here we report that the experimentally obtained IP1 of the heaviest actinide, lawrencium (Lr, atomic number 103), is 4.96(+0.08)(-0.07) electronvolts.	Lawrencium	78-88	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	48-51
25855457-7	2015	Here we report that the experimentally obtained IP1 of the heaviest actinide, lawrencium (Lr, atomic number 103), is 4.96(+0.08)(-0.07) electronvolts.	Lawrencium	90-92	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	48-51
23929704-1	2015	Previously, we have reported alterations to HSP27 during Microcystin-LR (MC-LR)-induced cytoskeletal reorganization in the human liver cell line HL7702.	Lawrencium	68-71	heat shock protein family B (small) member 1	Homo sapiens	44-49
24689655-8	2014	These results indicate that NPC5 mediates LR development in response to salt stress and suggest that DAG functions as a lipid mediator in the stress signalling.	Lawrencium	42-44	non-specific phospholipase C5	Arabidopsis thaliana	28-32
24366686-7	2014	H2O2-induced LR formation was inhibited by an HO-1 inhibitor zinc protoporphyrin IX (Znpp) in wild-type and severely impaired in HY1 mutant hy1-100.	Lawrencium	13-15	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	129-132
24366686-7	2014	H2O2-induced LR formation was inhibited by an HO-1 inhibitor zinc protoporphyrin IX (Znpp) in wild-type and severely impaired in HY1 mutant hy1-100.	Lawrencium	13-15	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	140-143
22386762-6	2012	Live-birth rate (LBR)/patient was higher in the LR-Accu-Vit group (30.2%) than the LR-fresh group (22.4%).	Lawrencium	48-50	vitrin	Homo sapiens	56-59
22386762-7	2012	Cumulative LBR/patient was statistically higher in the LR-Accu-Vit group (36.4%) than the LR-fresh group (23.7%) and a similar outcome was observed among patients aged &gt;=40years (LR-Accu-Vit 15.8% versus LR-fresh 7.1%).	Lawrencium	55-57	vitrin	Homo sapiens	63-66
22386762-7	2012	Cumulative LBR/patient was statistically higher in the LR-Accu-Vit group (36.4%) than the LR-fresh group (23.7%) and a similar outcome was observed among patients aged &gt;=40years (LR-Accu-Vit 15.8% versus LR-fresh 7.1%).	Lawrencium	55-57	vitrin	Homo sapiens	190-193
22386762-8	2012	The LR-Accu-Vit group had more cycles with embryo cryopreservation (LR-Accu-Vit 28.9% versus LR-fresh 8.7%).	Lawrencium	4-6	vitrin	Homo sapiens	12-15
22386762-8	2012	The LR-Accu-Vit group had more cycles with embryo cryopreservation (LR-Accu-Vit 28.9% versus LR-fresh 8.7%).	Lawrencium	4-6	vitrin	Homo sapiens	76-79
21698763-9	2011	The IC50 of PP1Y306A for the inhibitor microcystin-LR was threefold higher than that of PP1wt, whereas those of PP1Y306E for tautomycin and norcantharidin were 15-fold and 10-fold higher, respectively.	Lawrencium	50-53	neuropeptide Y receptor Y4	Homo sapiens	12-15
21504230-12	2011	The enzymes mainly expressed in the liver and gastrointestinal tract, GSTA1-1, T1-1, and M1-1, seemed to be mainly involved in the MC-LR detoxification after oral exposure, whereas P1-1 kinetics and location in the skin suggest a role related to dermal exposure.	Lawrencium	134-136	glutathione S-transferase alpha 1	Homo sapiens	70-77
21504230-12	2011	The enzymes mainly expressed in the liver and gastrointestinal tract, GSTA1-1, T1-1, and M1-1, seemed to be mainly involved in the MC-LR detoxification after oral exposure, whereas P1-1 kinetics and location in the skin suggest a role related to dermal exposure.	Lawrencium	134-136	CD2 molecule	Homo sapiens	79-83
21504230-12	2011	The enzymes mainly expressed in the liver and gastrointestinal tract, GSTA1-1, T1-1, and M1-1, seemed to be mainly involved in the MC-LR detoxification after oral exposure, whereas P1-1 kinetics and location in the skin suggest a role related to dermal exposure.	Lawrencium	134-136	exosome component 6	Homo sapiens	181-185
19914217-9	2010	Similarly, a GHR that lacks the ECD, except for the membrane-proximal ECD stem region, was only minimally LR-concentrated.	Lawrencium	106-108	growth hormone receptor	Homo sapiens	13-16
20421190-9	2010	Although Akt signaling was activated, the accumulation of p53 led cells to apoptosis after treatment with 50 nM microcystin-LR for 24 hr.	Lawrencium	124-126	AKT serine/threonine kinase 1	Homo sapiens	9-12
20421190-9	2010	Although Akt signaling was activated, the accumulation of p53 led cells to apoptosis after treatment with 50 nM microcystin-LR for 24 hr.	Lawrencium	124-126	tumor protein p53	Homo sapiens	58-61
20141116-7	2010	Only CD24, among the two smaller size LR-CDs, displays resemblance during short simulation intervals to one of the conformations of CD26.	Lawrencium	38-40	CD24 molecule	Homo sapiens	5-9
20141116-7	2010	Only CD24, among the two smaller size LR-CDs, displays resemblance during short simulation intervals to one of the conformations of CD26.	Lawrencium	38-40	dipeptidyl peptidase 4	Homo sapiens	132-136
21069807-9	2011	Hence, we propose that downregulation in the expression of the PCFT and the RFC in colon results in reduced levels of these transporters in colon apical membrane LR as a mechanism of folate malabsorption during chronic alcoholism.	Lawrencium	162-164	solute carrier family 46 member 1	Rattus norvegicus	63-67
20634435-4	2010	We examined the association of DRA with LR using the nonionic detergent Triton X-100.	Lawrencium	40-42	solute carrier family 26 member 3	Homo sapiens	31-34
20630458-12	2010	CONCLUSIONS: In patients undergoing PCI, LR to clopidogrel assessed by VASP-FCT is an independent predictor of cardiovascular death at the PRI cutoff value of &gt; or =61%.	Lawrencium	41-43	vasodilator stimulated phosphoprotein	Homo sapiens	71-75
24678079-13	2005	The mean percentage reduction in DBP was also significantly greater in the T + R group compared with that in the L + R group (17.3% vs 12.5%; P &lt; 0.05).	Lawrencium	113-118	D-box binding PAR bZIP transcription factor	Homo sapiens	33-36
19531490-5	2009	Phospho-GST-MYPT1 fragments docked directly at the active site of MLCP, and this was blocked by a PP1/PP2A inhibitor microcystin (MC)-LR or by mutation of the active sites in PP1.	Lawrencium	132-136	glutathione S-transferase kappa 1	Homo sapiens	8-11
19435934-4	2009	We demonstrate that, whereas exogenous jasmonate promotes LR formation in wild-type plants, it represses LR formation in jdl1/asa1-1.	Lawrencium	105-107	anthranilate synthase alpha subunit 1	Arabidopsis thaliana	121-125
18579701-9	2008	In parallel, increased colocalization of NKCC2 with the LR ganglioside GM1 and their polar translocation were assessed by confocal analysis.	Lawrencium	56-58	solute carrier family 12 member 1	Rattus norvegicus	41-46
19531490-5	2009	Phospho-GST-MYPT1 fragments docked directly at the active site of MLCP, and this was blocked by a PP1/PP2A inhibitor microcystin (MC)-LR or by mutation of the active sites in PP1.	Lawrencium	132-136	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	12-17
19531490-5	2009	Phospho-GST-MYPT1 fragments docked directly at the active site of MLCP, and this was blocked by a PP1/PP2A inhibitor microcystin (MC)-LR or by mutation of the active sites in PP1.	Lawrencium	132-136	neuropeptide Y receptor Y4	Homo sapiens	98-101
19531490-5	2009	Phospho-GST-MYPT1 fragments docked directly at the active site of MLCP, and this was blocked by a PP1/PP2A inhibitor microcystin (MC)-LR or by mutation of the active sites in PP1.	Lawrencium	132-136	protein phosphatase 2 phosphatase activator	Homo sapiens	102-106
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD28 molecule	Homo sapiens	21-25
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	interleukin 2 receptor subunit alpha	Homo sapiens	170-174
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD28 molecule	Homo sapiens	176-180
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	integrin subunit beta 1	Homo sapiens	182-186
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	interleukin 2 receptor subunit alpha	Homo sapiens	213-217
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	dipeptidyl peptidase 4	Homo sapiens	229-233
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD27 molecule	Homo sapiens	235-239
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD24 molecule	Homo sapiens	288-292
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD24 molecule	Homo sapiens	304-308
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	interleukin 2 receptor subunit alpha	Homo sapiens	213-217
17226747-7	2007	An elongated cavity (CD28) or a double parallel strand in different specific representations are the dominating motifs in the LR-CDs studied: with loops at the two ends (CD25, CD28, CD29), with a loop at one end (CD25), twisted (CD26, CD27) or twisted with an open portion in the middle (CD24), helical (CD24, CD25), or linking two loops from one of their sides (CD27).	Lawrencium	126-128	CD27 molecule	Homo sapiens	363-367
14699494-8	2004	In Caco-2 cells, while EGF stimulated BB NHE3, Akt2 was active in both LR and DS pools.	Lawrencium	71-73	AKT serine/threonine kinase 2	Homo sapiens	47-51