PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1324718-5	1992	The possibility of Ca(2+)-dependent changes in the rigidity or conformation of fibrinogen was excluded by examining the submicrosecond time-resolved fluorescence depolarization of 1-methylpyrene conjugates of the protein in the presence of different calcium concentrations.	1-methylpyrene	180-194	fibrinogen beta chain	Homo sapiens	79-89
33035519-0	2020	1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1.	1-methylpyrene	0-14	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	133-139
33035519-0	2020	1-Methylpyrene induces chromosome loss and mitotic apparatus damage in a Chinese hamster V79-derived cell line expressing both human CYP1A2 and sulfotransferase 1A1.	1-methylpyrene	0-14	sulfotransferase family 1A member 1	Homo sapiens	144-164
27637483-7	2016	1-Hydroxymethylpyrene (activated by SULT1A1) and 1-methylpyrene (activated sequentially by CYP2E1 and SULT1A1) produced the highest response with the 18h/6h treatment regimen.	1-methylpyrene	49-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	91-97
27637483-7	2016	1-Hydroxymethylpyrene (activated by SULT1A1) and 1-methylpyrene (activated sequentially by CYP2E1 and SULT1A1) produced the highest response with the 18h/6h treatment regimen.	1-methylpyrene	49-63	sulfotransferase family 1A member 1	Homo sapiens	102-109
27637483-8	2016	Moreover, mitotic arrest by 1-hydroxymethylpyrene was observed in V79-hCYP2E1-hSULT1A1 cells but not in V79 cells, and 1-methylpyrene arrested mitosis in V79-hCYP2E1-hSULT1A1 more strongly than in V79 cells.	1-methylpyrene	119-133	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	158-165
27637483-8	2016	Moreover, mitotic arrest by 1-hydroxymethylpyrene was observed in V79-hCYP2E1-hSULT1A1 cells but not in V79 cells, and 1-methylpyrene arrested mitosis in V79-hCYP2E1-hSULT1A1 more strongly than in V79 cells.	1-methylpyrene	119-133	sulfotransferase family 1A member 1	Homo sapiens	166-174
20391135-11	2010	Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion.	1-methylpyrene	8-22	interleukin 1 alpha	Homo sapiens	93-102
20391135-11	2010	Indeed, 1-methylpyrene or perylene, individually or when combined, significantly upregulated IL-1alpha and IL-6 secretion.	1-methylpyrene	8-22	interleukin 6	Homo sapiens	107-111
33035519-5	2020	The results indicated that 1-MP induced micronuclei in V79-hCYP1A2-hSULT1A1 cells from 0.125 to 2 muM under a 24 h/0 h (exposure/recovery) regime, while in the parental V79-Mz cells micronuclei were induced by 1-MP only at concentrations >= 8 muM; in both cases, the micronuclei induced by 1-MP were predominantly CENP-B positive.	1-methylpyrene	27-31	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-66
33035519-5	2020	The results indicated that 1-MP induced micronuclei in V79-hCYP1A2-hSULT1A1 cells from 0.125 to 2 muM under a 24 h/0 h (exposure/recovery) regime, while in the parental V79-Mz cells micronuclei were induced by 1-MP only at concentrations >= 8 muM; in both cases, the micronuclei induced by 1-MP were predominantly CENP-B positive.	1-methylpyrene	27-31	sulfotransferase family 1A member 1	Homo sapiens	67-75
33035519-5	2020	The results indicated that 1-MP induced micronuclei in V79-hCYP1A2-hSULT1A1 cells from 0.125 to 2 muM under a 24 h/0 h (exposure/recovery) regime, while in the parental V79-Mz cells micronuclei were induced by 1-MP only at concentrations >= 8 muM; in both cases, the micronuclei induced by 1-MP were predominantly CENP-B positive.	1-methylpyrene	27-31	major centromere autoantigen B	Cricetulus griseus	314-320
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	1-methylpyrene	7-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	120-127
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	1-methylpyrene	7-21	sulfotransferase family 1A member 1	Homo sapiens	128-136
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	1-methylpyrene	7-21	sulfotransferase family 1A member 1	Homo sapiens	142-150
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	1-methylpyrene	7-21	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	156-163
31112310-4	2020	First, 1-methylpyrene, 1-hydroxymethylpyrene, benzo[a]pyrene, and aflatoxin B1 significantly induced micronuclei in V79-hCYP1A2-hSULT1A1, V79-hSULT1A1, V79-hCYP1A1, and V79-hCYP1A2 cells, respectively.	1-methylpyrene	7-21	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	173-180
25243916-0	2015	Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expressing both human CYP2E1 and SULT1A1.	1-methylpyrene	16-30	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	116-122
25243916-0	2015	Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expressing both human CYP2E1 and SULT1A1.	1-methylpyrene	16-30	sulfotransferase family 1A member 1	Homo sapiens	127-134
25243916-9	2015	The effects of 1-HMP in V79-hCYP2E1-hSULT1A1 cells were blocked or reduced by addition of pentachlorophenol (PCP), a SULT1 inhibitor; the genotoxicity of 1-MP was significantly reduced by either 1-aminobenotrazole, a CYP2E1 inhibitor, or PCP.	1-methylpyrene	154-158	inner membrane mitochondrial protein	Homo sapiens	17-20