PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26044359-2	2015	Abt-348, Birb-796, Motesanib and Sorafenib are DFG-out multi-kinase inhibitors that have been reported to inhibit RET activity with good IC50 values.	birb	9-13	ret proto-oncogene	Homo sapiens	114-117
33132165-7	2020	Real-time monitoring of binding to p38alpha MAPK using fluoroprobe SKF-86002 showed quite rapid binding of PNU-120596 compared to BIRB-796 which is known as a slow binder.	birb	130-134	mitogen-activated protein kinase 14	Homo sapiens	35-43
33145838-4	2021	We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination.	birb	158-162	interleukin 6	Homo sapiens	26-30
33145838-4	2021	We observed inhibition of IL-6 and CXCL8 secretion from both lung fibroblast models by dexamethasone (maximal inhibition 40 - 90%) and the p38 MAPK inhibitor BIRB (maximal inhibition 30 - 60%), used alone and evidence of increased anti-inflammatory effects when used in combination.	birb	158-162	C-X-C motif chemokine ligand 8	Homo sapiens	35-40
28222148-9	2017	c-Myc, p-STAT1, p-STAT3, p-MAPK were all negatively regulated by miR-200a (P < 0.01 or P < 0.001); more important, the increase of c-Myc induced by miR-200a silencing was abolished by Nifuroxazide or BIRB 796 (P < 0.01 or P < 0.001).	birb	206-210	microRNA 200a	Homo sapiens	65-73
28222148-9	2017	c-Myc, p-STAT1, p-STAT3, p-MAPK were all negatively regulated by miR-200a (P < 0.01 or P < 0.001); more important, the increase of c-Myc induced by miR-200a silencing was abolished by Nifuroxazide or BIRB 796 (P < 0.01 or P < 0.001).	birb	206-210	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	137-142
27136566-6	2016	Our findings confirmed the involvement of p38 in accelerated cell senescence and identified p38 inhibitors suitable for in vivo use in WS, with BIRB 796 the most effective.	birb	144-148	mitogen-activated protein kinase 14	Homo sapiens	92-95
26400758-5	2016	In this study, we extend these observations using two next-generation p38 inhibitors (UR-13756 and BIRB 796) that have markedly improved selectivity and specificity compared to SB203580, to strengthen the evidence that the SASP is p38-dependent in human fibroblasts.	birb	99-103	mitogen-activated protein kinase 14	Homo sapiens	70-73
22464096-7	2012	BIRB 796 enhanced LPS-induced expression of IRF1 in J774 macrophages and in PMs from wild-type mice, and IRF1 expression was reduced in PMs from MKP-1 deficient mice.	birb	0-4	interferon regulatory factor 1	Mus musculus	44-48
24385947-6	2013	BIRB 796 reduced LPS-mediated IL-8 production in THP-1 cells but not in Raw 264.7 cells.	birb	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
22727776-7	2013	RESULTS: In vitro, BIRB 796 reduced LPS induced p38 MAPK phosphorylation in alveolar macrophage and respiratory epithelial cell lines and diminished cytokine/chemokine release.	birb	19-23	mitogen-activated protein kinase 14	Mus musculus	48-56
22727776-8	2013	In vivo, BIRB 796 circumvented p38 MAPK phosphorylation in both LPS and LTA induced inflammation.	birb	9-13	mitogen-activated protein kinase 14	Mus musculus	31-39
22464096-7	2012	BIRB 796 enhanced LPS-induced expression of IRF1 in J774 macrophages and in PMs from wild-type mice, and IRF1 expression was reduced in PMs from MKP-1 deficient mice.	birb	0-4	dual specificity phosphatase 1	Mus musculus	145-150
14561087-0	2003	Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).	birb	167-171	mitogen-activated protein kinase 14	Homo sapiens	40-48
22234699-4	2012	Of the 75 small molecules screened, the p38 MAPK inhibitor BIRB 796 and dasatinib potently suppressed TLR8-dependent expression of the reporter gene.	birb	59-63	mitogen-activated protein kinase 14	Mus musculus	40-48
22234699-4	2012	Of the 75 small molecules screened, the p38 MAPK inhibitor BIRB 796 and dasatinib potently suppressed TLR8-dependent expression of the reporter gene.	birb	59-63	toll-like receptor 8	Mus musculus	102-106
20621496-3	2010	Here, we present a structural comparison of the important and similar interactions necessary for Gleevec(R), Nexavar, and BIRB-796 to bind to their respective DFG-out allosteric binding pockets and the selectivity of each with respect to c-Abl, B-Raf, and p38alpha.	birb	122-126	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	238-243
20621496-3	2010	Here, we present a structural comparison of the important and similar interactions necessary for Gleevec(R), Nexavar, and BIRB-796 to bind to their respective DFG-out allosteric binding pockets and the selectivity of each with respect to c-Abl, B-Raf, and p38alpha.	birb	122-126	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	245-250
20621496-3	2010	Here, we present a structural comparison of the important and similar interactions necessary for Gleevec(R), Nexavar, and BIRB-796 to bind to their respective DFG-out allosteric binding pockets and the selectivity of each with respect to c-Abl, B-Raf, and p38alpha.	birb	122-126	mitogen-activated protein kinase 14	Homo sapiens	256-264
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	birb	126-130	interleukin 1 beta	Homo sapiens	23-40
20590617-4	2010	EXPERIMENTAL APPROACH: Interleukin-1beta (IL-1beta)-stimulated human OA chondrocytes were treated with the p38MAPK inhibitors Birb 796, pamapimod, SB203580 and the new substance CBS-3868.	birb	126-130	interleukin 1 beta	Homo sapiens	42-50
20590617-10	2010	Birb 796 and CBS-3868 showed a higher efficacy than SB203580 and pamapimod at inhibiting the expression of COX-2 and MMP13 genes, as well as PGE(2) release.	birb	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	107-112
20590617-10	2010	Birb 796 and CBS-3868 showed a higher efficacy than SB203580 and pamapimod at inhibiting the expression of COX-2 and MMP13 genes, as well as PGE(2) release.	birb	0-4	matrix metallopeptidase 13	Homo sapiens	117-122
16527696-7	2006	A significant, dose-dependent decrease of C-reactive protein level was observed transiently after BIRB 796 after 1 week with a return to baseline level over time.	birb	98-102	C-reactive protein	Homo sapiens	42-60
21547253-2	2011	iNOS expression was induced by a cytokine mixture (TNF, IFNgamma and IL-1beta) in A549 cells and by LPS in J774 cells, and it was inhibited by p38 MAPK inhibitors SB202190 and BIRB 796.	birb	176-180	nitric oxide synthase 2, inducible	Mus musculus	0-4
21547253-2	2011	iNOS expression was induced by a cytokine mixture (TNF, IFNgamma and IL-1beta) in A549 cells and by LPS in J774 cells, and it was inhibited by p38 MAPK inhibitors SB202190 and BIRB 796.	birb	176-180	mitogen-activated protein kinase 14	Mus musculus	143-146
20619343-11	2010	MMP-1 and MMP-10 expression were inhibited by BIRB-0796 but not SB203580, suggesting roles for p38-gamma/delta.	birb	46-50	matrix metallopeptidase 1	Homo sapiens	0-5
20619343-11	2010	MMP-1 and MMP-10 expression were inhibited by BIRB-0796 but not SB203580, suggesting roles for p38-gamma/delta.	birb	46-50	matrix metallopeptidase 10	Homo sapiens	10-16
20619343-11	2010	MMP-1 and MMP-10 expression were inhibited by BIRB-0796 but not SB203580, suggesting roles for p38-gamma/delta.	birb	46-50	mitogen-activated protein kinase 12	Homo sapiens	95-110
17173546-3	2007	BIRB 796 blocked baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation, thereby enhancing cytotoxicity and caspase activation.	birb	0-4	heat shock protein family B (small) member 1	Homo sapiens	80-85
17173546-5	2007	Importantly, BIRB 796 inhibited Hsp27 phosphorylation induced by 17-AAG plus bortezomib, thereby enhancing cytotoxicity.	birb	13-17	heat shock protein family B (small) member 1	Homo sapiens	32-37
17173546-5	2007	Importantly, BIRB 796 inhibited Hsp27 phosphorylation induced by 17-AAG plus bortezomib, thereby enhancing cytotoxicity.	birb	13-17	N-methylpurine DNA glycosylase	Homo sapiens	68-71
11937566-6	2002	Both doses of BIRB 796 BS significantly inhibited LPS-induced p38 MAPK activation in the leukocyte fraction of the volunteers.	birb	14-18	mitogen-activated protein kinase 14	Homo sapiens	62-65
12576315-4	2003	BIRB 796 BS also dose dependently attenuated the activation and subsequent inhibition of the fibrinolytic system (plasma tissue-type plasminogen activator, plasmin-alpha2-antiplasmin complexes, and plasminogen activator inhibitor type 1) and endothelial cell activation (plasma soluble E-selectin and von Willebrand factor).	birb	0-4	plasminogen activator, tissue type	Homo sapiens	121-154