PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2413893-0	1985	Aliphatic aldehydes promote myelin basic protein-induced fusion of phospholipid vesicles.	aliphatic aldehydes	0-19	myelin basic protein	Homo sapiens	28-48
2413893-4	1985	The ability of aliphatic aldehydes to promote myelin basic protein-induced membrane fusion may be of relevance to myelin structure and function and, particularly, to the pathology of demyelinating diseases such as multiple sclerosis.	aliphatic aldehydes	15-34	myelin basic protein	Homo sapiens	46-66
7060228-1	1982	The results of this paper demonstrate for the first time that a number of saturated aliphatic aldehydes, e.g. octanal, when incubated with rat liver microsomes and NADPH in vitro cause the time dependent destruction of cytochrome P-450 and the formation of green pigments.	aliphatic aldehydes	84-103	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	219-235
735620-0	1978	[Reaction of aliphatic aldehydes with aldehyde oxidase from swine liver].	aliphatic aldehydes	13-32	aldehyde oxidase 1	Sus scrofa	38-54
5914892-0	1966	Binding of aliphatic aldehydes to collagen and elastin matrices.	aliphatic aldehydes	11-30	elastin	Homo sapiens	47-54
28126723-6	2017	Wild-type Ald6p showed activity only with aliphatic aldehydes.	aliphatic aldehydes	42-61	aldehyde dehydrogenase (NADP(+)) ALD6	Saccharomyces cerevisiae S288C	10-15
31066944-1	2019	A sequence of a Baeyer-Villiger oxidation and a Lewis acid-promoted reduction of the resulting formate with Et3 SiH enabled the metal-free formal decarbonylation of tertiary and secondary aliphatic aldehydes.	aliphatic aldehydes	188-207	endothelin 3	Homo sapiens	108-111
31086867-2	2019	Aliphatic aldehydes were oxidatively decarbonylated into 1 , 2  and 3  alkyl radicals conveniently, allowing for the subsequent cascade construction of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds via radical addition and HAS-type cyclization.	aliphatic aldehydes	0-19	Sp2 transcription factor	Homo sapiens	177-182
29899187-4	2018	In this study, we performed a cell-free in-vitro assay utilising a peptide mimic of the receptor, and demonstrated that SR-B1 could recognise aliphatic aldehydes (e.g., tetradecanal), a distinct class of volatile odorants, as potential ligands.	aliphatic aldehydes	142-161	scavenger receptor class B, member 1	Mus musculus	120-125
28126723-7	2017	Ald4p, on the contrary, showed activity with benzaldehyde along with a limited range of aliphatic aldehydes.	aliphatic aldehydes	88-107	aldehyde dehydrogenase (NADP(+)) ALD4	Saccharomyces cerevisiae S288C	0-5
27442526-3	2016	In situ NMR studies showed a different reaction pathway when compared to aliphatic aldehydes that yield the syn adduct as major isomer.	aliphatic aldehydes	73-92	synemin	Homo sapiens	108-111
23839774-2	2013	By employing Montmorrilonite K10 as the acid catalyst and 3 A molecular sieves as the dehydrating agent, yields that reached 70 % could be achieved with some aliphatic aldehydes.	aliphatic aldehydes	158-177	keratin 10	Homo sapiens	29-32
25787882-2	2015	epsilon-Amido-allylindiums generated in situ from N-Ts-4-vinylazetidin-2-ones in the presence of 2 eq. of InI and catalytic amounts of Pd(PPh3)4 react with a number of aromatic and aliphatic aldehydes with effective remote 1,5-stereocontrol to afford (3Z)-2,6-anti-enediols as major products in good yields and with excellent diastereoselectivity.	aliphatic aldehydes	181-200	PHD finger protein 5A	Homo sapiens	106-109
25787882-2	2015	epsilon-Amido-allylindiums generated in situ from N-Ts-4-vinylazetidin-2-ones in the presence of 2 eq. of InI and catalytic amounts of Pd(PPh3)4 react with a number of aromatic and aliphatic aldehydes with effective remote 1,5-stereocontrol to afford (3Z)-2,6-anti-enediols as major products in good yields and with excellent diastereoselectivity.	aliphatic aldehydes	181-200	protein phosphatase 4 catalytic subunit	Homo sapiens	138-142
25354489-1	2014	The application of 2-arylcyclopropylmethanols as substitutes to homoallyl aryl alcohols and their reactions with aliphatic aldehydes in the presence of SnCl4 in CH2Cl2 leads to an efficient Prins cyclization to generate cis-2,6-disubstituted tetrahydropyrans in high yields.	aliphatic aldehydes	113-132	suppressor of cytokine signaling 2	Homo sapiens	220-225
22849540-5	2012	An adhC mutant was more susceptible than wild-type Haemophilus influenzae Rd KW20 to killing by various short chain aliphatic aldehydes, all of which can be generated endogenously during cell metabolism but are also produced by the host as part of the innate immune response.	aliphatic aldehydes	116-135	S-(hydroxymethyl)glutathione dehydrogenase	Haemophilus influenzae Rd KW20	3-7
19860831-1	2009	Fatty aldehyde dehydrogenase (FALDH; also known as ALDH3A2 or ALDH10) oxidizes medium- or long-chain aliphatic aldehydes.	aliphatic aldehydes	101-120	aldehyde dehydrogenase 3 family member A2	Homo sapiens	0-28
21999103-1	2011	A chemo- and stereoselective asymmetric direct cross-aldol reaction between aliphatic aldehydes and alpha-chloroaldehydes has been developed as a method for the formation of the sole cross-aldol adduct with both enantio- and diastereocontrol, and either anti- or syn-aldol adducts were obtained in good to excellent stereoselectivities by use of proline or a novel axially chiral amino sulfonamide as catalyst.	aliphatic aldehydes	76-95	synemin	Homo sapiens	263-266
21229876-1	2010	The salivary aldehyde dehydrogenase (ALDH3A1) oxidizes mainly aromatic and long chain aliphatic aldehydes.	aliphatic aldehydes	86-105	aldehyde dehydrogenase 3 family member A1	Homo sapiens	37-44
20411365-4	2010	With NADPH as a cofactor, GOX0644 exhibited better activity to aromatic aldehydes, especially o-chlorobenzaldehyde, compared to aliphatic aldehydes.	aliphatic aldehydes	128-147	oxidoreductase	Gluconobacter oxydans 621H	26-33
20616185-9	2010	Human ALDH1B1 had an exclusive preference for NAD(+) as the cofactor and was catalytically active toward short- and medium-chain aliphatic aldehydes, aromatic aldehydes, and the products of lipid peroxidation, 4-hydroxynonenal and malondialdehyde.	aliphatic aldehydes	129-148	aldehyde dehydrogenase 1 family member B1	Homo sapiens	6-13
19860831-1	2009	Fatty aldehyde dehydrogenase (FALDH; also known as ALDH3A2 or ALDH10) oxidizes medium- or long-chain aliphatic aldehydes.	aliphatic aldehydes	101-120	aldehyde dehydrogenase 3 family member A2	Homo sapiens	30-35
19860831-1	2009	Fatty aldehyde dehydrogenase (FALDH; also known as ALDH3A2 or ALDH10) oxidizes medium- or long-chain aliphatic aldehydes.	aliphatic aldehydes	101-120	aldehyde dehydrogenase 3 family member A2	Homo sapiens	51-58
19860831-1	2009	Fatty aldehyde dehydrogenase (FALDH; also known as ALDH3A2 or ALDH10) oxidizes medium- or long-chain aliphatic aldehydes.	aliphatic aldehydes	101-120	aldehyde dehydrogenase 3 family member A2	Homo sapiens	62-68
17655273-10	2007	Aliphatic aldehydes such as glyoxal, acetaldehyde, and propanal are relatively weak inactivators of PTP1B under the conditions employed here.	aliphatic aldehydes	0-19	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	100-105
18498778-5	2008	BADH can utilize a range of aromatic substrates and will also operate efficiently with cyclohexanal as well as medium-chain aliphatic aldehydes.	aliphatic aldehydes	124-143	benzaldehyde dehydrogenase	Pseudomonas putida	0-4
17867698-1	2007	syn-beta-Hydroxyallylsilanes of general structure 11 and 28 are prepared in 50-86% yield and 91-95% ee (for aliphatic aldehydes; 50% ee for benzaldehyde) via the BF(3).Et(2)O-promoted gamma-silylallylboration reactions, using reagents 14 and 15.	aliphatic aldehydes	108-127	synemin	Homo sapiens	0-3
17579868-1	2007	Using an operant conditioning paradigm, we tested the ability of CD-1 mice to discriminate between members of a homologous series of aliphatic aldehydes presented at four different concentrations.	aliphatic aldehydes	133-152	CD1 antigen complex	Mus musculus	65-69
12943535-7	2003	Short-chain aliphatic aldehydes, such as acetaldehyde, propionaldehyde and malondialdehyde, were found to be very poor substrates for human ALDH3A1.	aliphatic aldehydes	12-31	aldehyde dehydrogenase 3 family member A1	Homo sapiens	140-147
17382292-5	2007	Human ALDH3B1 was baculovirus-expressed and found to be catalytically active towards medium- and long-chain aliphatic aldehydes and the aromatic aldehyde benzaldehyde.	aliphatic aldehydes	108-127	aldehyde dehydrogenase 3 family member B1	Homo sapiens	6-13
16897483-9	2006	They both show strong preference for aliphatic aldehydes but Cm-ADH1 is capable of reducing branched aldehydes such as 3-methylbutyraldehyde, whereas Cm-ADH2 cannot.	aliphatic aldehydes	37-56	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	64-68
16897483-9	2006	They both show strong preference for aliphatic aldehydes but Cm-ADH1 is capable of reducing branched aldehydes such as 3-methylbutyraldehyde, whereas Cm-ADH2 cannot.	aliphatic aldehydes	37-56	alcohol dehydrogenase ADH2	Saccharomyces cerevisiae S288C	153-157
16545391-1	2006	A new precise and sensitive method was used for the quantification of aliphatic aldehydes from C5 to C11 in highly ethanolic beverages such as freshly distilled spirits.	aliphatic aldehydes	70-89	RNA polymerase III subunit K	Homo sapiens	101-104
16253352-0	2006	Olfactory sensitivity for aliphatic aldehydes in CD-1 mice.	aliphatic aldehydes	26-45	CD1 antigen complex	Mus musculus	49-53
17203133-2	2006	The homoallylic alcohol derived from 1,3-dimethylallylation of (-)-menthone undergoes an efficient allyl-transfer reaction with a wide range of aliphatic aldehydes in the presence of an acid catalyst to give rise to the corresponding 4-methyl-2(E)-penten-4-yl-5-ol products in good yields with high enantio- and 4,5-syn-selectivities.	aliphatic aldehydes	144-163	synemin	Homo sapiens	316-319
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	158-177	mitochondrial aldehyde dehydrogenase 2	Zea mays	34-38
12895059-1	2003	The reaction of chiral sulfinimines 1c-g derived from aliphatic aldehydes with TMSCN in the presence of CsF gave alpha-amino nitriles in high diastereoselectivity and yield.	aliphatic aldehydes	54-73	colony stimulating factor 2	Homo sapiens	104-107
12926924-2	2003	This practical methodology provides both syn and anti propionate units and other homoallylic alcohols with very high levels of diastereo- and enantioselectivity for several substrates, including functionalized aliphatic aldehydes useful toward the elaboration of complex natural products.	aliphatic aldehydes	210-229	synemin	Homo sapiens	41-44
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	158-177	aldehyde dehydrogenase 2	Zea mays	43-47
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	158-177	mitochondrial aldehyde dehydrogenase 2	Zea mays	103-107
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	158-177	mitochondrial aldehyde dehydrogenase 2	Zea mays	34-37
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	236-255	mitochondrial aldehyde dehydrogenase 2	Zea mays	34-38
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	236-255	aldehyde dehydrogenase 2	Zea mays	43-47
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	236-255	mitochondrial aldehyde dehydrogenase 2	Zea mays	103-107
12481049-6	2002	Kinetic analyses established that RF2A and RF2B have quite different substrate specificities; although RF2A can oxidize a broad range of aldehydes, including aliphatic aldehydes and aromatic aldehydes, RF2B can oxidize only short-chain aliphatic aldehydes.	aliphatic aldehydes	236-255	mitochondrial aldehyde dehydrogenase 2	Zea mays	34-37
11073717-1	2000	Fatty aldehyde dehydrogenase (FALDH) is a microsomal enzyme that catalyzes the oxidation of aliphatic aldehydes to fatty acids.	aliphatic aldehydes	92-111	aldehyde dehydrogenase family 3, subfamily A2	Mus musculus	0-28
12659120-0	2002	Spin-imposed stereoselection in the photocycloaddition of (Z)- and (E)-cyclooctene to aliphatic aldehydes.	aliphatic aldehydes	86-105	spindlin 1	Homo sapiens	0-4
12659120-1	2002	The simple diastereoselectivity of the photocycloaddition of aliphatic aldehydes to (Z)- and (E)-cyclooctene was analyzed as a function of the substrate concentrations and applied to spin mapping.	aliphatic aldehydes	61-80	spindlin 1	Homo sapiens	183-187
11306050-0	2001	Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.	aliphatic aldehydes	101-120	aldehyde dehydrogenase 3 family member A1	Homo sapiens	49-56
11073660-0	2000	Spin-directed stereoselectivity of carbonyl-alkene photocycloadditions The concentration dependence of the Paterno-Buchi photocycloaddition of the two cyclic enolethers 2,3-dihydrofuran and 2,3-dihydropyran, respectively, with aromatic as well as aliphatic aldehydes was studied.	aliphatic aldehydes	247-266	spindlin 1	Homo sapiens	0-4
11073717-1	2000	Fatty aldehyde dehydrogenase (FALDH) is a microsomal enzyme that catalyzes the oxidation of aliphatic aldehydes to fatty acids.	aliphatic aldehydes	92-111	aldehyde dehydrogenase family 3, subfamily A2	Mus musculus	30-35
10199577-2	1999	Intragastric administration of TCE to rats at 0.05 or 0.2 ml/kg for 1 week significantly inhibited ALDH activity for aliphatic aldehydes of short chains in the mitochondrial and cytosolic fractions of rat liver, respectively, but had no effect on the activity for long chain aliphatic aldehydes.	aliphatic aldehydes	117-136	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	99-103
10812837-6	2000	Investigation of such situations has generated data implicating GSTT1, GSTM1, NAT2, and NQO1 polymorphisms in biological monitoring of some chemicals; the ALDH2 polymorphism is the likely link between the genotype and the metabolism of low molecular aliphatic aldehydes.	aliphatic aldehydes	250-269	aldehyde dehydrogenase 2 family member	Homo sapiens	155-160
10510318-7	1999	Many of the compounds which are substrates for AKR1A1 also serve as substrates for AKR1B1, though the latter enzyme was shown to display a specific activity significantly less than that of AKR1A1 for most of the aromatic and aliphatic aldehydes studied.	aliphatic aldehydes	225-244	aldo-keto reductase family 1 member A1	Homo sapiens	47-53
10510318-7	1999	Many of the compounds which are substrates for AKR1A1 also serve as substrates for AKR1B1, though the latter enzyme was shown to display a specific activity significantly less than that of AKR1A1 for most of the aromatic and aliphatic aldehydes studied.	aliphatic aldehydes	225-244	aldo-keto reductase family 1 member B	Homo sapiens	83-89
10510318-7	1999	Many of the compounds which are substrates for AKR1A1 also serve as substrates for AKR1B1, though the latter enzyme was shown to display a specific activity significantly less than that of AKR1A1 for most of the aromatic and aliphatic aldehydes studied.	aliphatic aldehydes	225-244	aldo-keto reductase family 1 member A1	Homo sapiens	189-195
10199577-2	1999	Intragastric administration of TCE to rats at 0.05 or 0.2 ml/kg for 1 week significantly inhibited ALDH activity for aliphatic aldehydes of short chains in the mitochondrial and cytosolic fractions of rat liver, respectively, but had no effect on the activity for long chain aliphatic aldehydes.	aliphatic aldehydes	275-294	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	99-103
2690658-4	1989	The cytoplasmic enzyme, which is the classical glyceraldehyde-3-phosphate dehydrogenase, is inactive with acetaldehyde as substrate; the isozymes that are active with short chain aliphatic aldehydes are localized in the mitochondrial fraction.	aliphatic aldehydes	179-198	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	47-87
8545597-3	1995	Free fatty acids and corresponding aliphatic aldehydes induced an inhibition of membrane-bound AChE, effectively decreased the bulk lipid and protein-bound lipid microviscosity, and quenched the fluorescence of membrane-bound ANS.	aliphatic aldehydes	35-54	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
2690658-5	1989	Properties of glyceraldehyde-3-phosphate dehydrogenase isozymes with respect to short chain aliphatic aldehydes and inhibition by disulfiram are described.	aliphatic aldehydes	92-111	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	14-54
2803227-7	1989	As previously reported in ALDH1 and ALDH2, a higher catalytic efficiency (Vmax/Km) for oxidation of long-chain aliphatic aldehydes was found in ALDH3, suggesting that these enzymes have a hydrophobic barrel-shape substrate binding pocket.	aliphatic aldehydes	111-130	aldehyde dehydrogenase 1 family member A1	Homo sapiens	26-31
2803227-7	1989	As previously reported in ALDH1 and ALDH2, a higher catalytic efficiency (Vmax/Km) for oxidation of long-chain aliphatic aldehydes was found in ALDH3, suggesting that these enzymes have a hydrophobic barrel-shape substrate binding pocket.	aliphatic aldehydes	111-130	aldehyde dehydrogenase 2 family member	Homo sapiens	36-41
2803227-7	1989	As previously reported in ALDH1 and ALDH2, a higher catalytic efficiency (Vmax/Km) for oxidation of long-chain aliphatic aldehydes was found in ALDH3, suggesting that these enzymes have a hydrophobic barrel-shape substrate binding pocket.	aliphatic aldehydes	111-130	aldehyde dehydrogenase 3 family member A1	Homo sapiens	144-149
3423423-4	1987	The accuracy of the ADH-ALDH assay was investigated by comparison of the reaction kinetics determined by this method with those obtained using commercially available aliphatic aldehydes as substrates.	aliphatic aldehydes	166-185	aldo-keto reductase family 1 member A1	Homo sapiens	20-23
2430621-0	1986	Modulation of myelin basic protein-induced aggregation and fusion of liposomes by cholesterol, aliphatic aldehydes and alkanes.	aliphatic aldehydes	95-114	myelin basic protein	Homo sapiens	14-34
2430621-8	1986	In the presence of cholesterol, myelin basic protein-induced fusion of the liposomes becomes much more sensitive to the presence of aliphatic aldehydes or alkanes.	aliphatic aldehydes	132-151	myelin basic protein	Homo sapiens	32-52