PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12207498-3	2002	Remarkable metabolism by the multiple CYP forms was observed toward dibenzo-p-dioxin (DD) and mono-, di-, and trichloroDDs.	dibenzo(1,4)dioxin	68-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-41
22004969-1	2011	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses.	dibenzo(1,4)dioxin	34-51	aryl hydrocarbon receptor	Homo sapiens	103-128
22004969-1	2011	Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) binding with the aryl hydrocarbon receptor (AhR) have been correlated with many toxic responses.	dibenzo(1,4)dioxin	34-51	aryl hydrocarbon receptor	Homo sapiens	130-133
20935161-1	2010	The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system.	dibenzo(1,4)dioxin	95-112	aryl-hydrocarbon receptor	Mus musculus	4-29
20935161-1	2010	The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system.	dibenzo(1,4)dioxin	95-112	aryl-hydrocarbon receptor	Mus musculus	31-34
16231135-1	2005	A radial basis function neural network (RBFN) has been used to correlate Ah receptor-binding affinities of polychlorinated, polybrominated, and polychlorinated-brominated dibenzo-p-dioxins with molecular weight and eight net atomic charge descriptors.	dibenzo(1,4)dioxin	171-188	aryl hydrocarbon receptor	Homo sapiens	73-84
16231135-5	2005	The significance of the RBFN model with net atomic charges as descriptors suggests that electrostatic and dispersion-type interactions play important roles in governing the Ah receptor binding of polychlorinated, polybrominated, and polychlorinated-brominated dibenzo-p-dioxins.	dibenzo(1,4)dioxin	260-277	aryl hydrocarbon receptor	Homo sapiens	173-184
16111922-4	2005	The AHR mRNA expression levels exhibited significant positive correlations with total TEQs and most of individual congener TEQs derived from polychorinated dibenzo-p-dioxins, dibenzofurans and non-ortho coplanar polychorinated biphenyls (PCBs), indicating the transcriptional up-regulation of AHR expression by these congeners.	dibenzo(1,4)dioxin	156-173	aryl hydrocarbon receptor	Homo sapiens	4-7
15870332-2	2005	The biotransformation activity of RW1 phenotypes is determined primarily by the presence and concentration of the dioxin dioxygenase, an enzyme initiating the degradation of both dibenzo-p-dioxin and dibenzofuran (DF).	dibenzo(1,4)dioxin	179-195	transmembrane protein 131	Mus musculus	34-37
25061970-3	2014	Here, we report that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules.	dibenzo(1,4)dioxin	147-164	bone morphogenetic protein 1	Homo sapiens	25-28
21174454-9	2011	In previous studies of the pyrolysis of 2-MCP under identical conditions, 4,6-DCDF and dibenzo-p-dioxin (DD) were observed with maximum yields of ~0.2% and ~0.1%, respectively, along with trace quantities of 1-monochlorodibenzo-p-dioxin (1-MCDD).	dibenzo(1,4)dioxin	87-103	sallimus	Drosophila melanogaster	42-45
21174454-9	2011	In previous studies of the pyrolysis of 2-MCP under identical conditions, 4,6-DCDF and dibenzo-p-dioxin (DD) were observed with maximum yields of ~0.2% and ~0.1%, respectively, along with trace quantities of 1-monochlorodibenzo-p-dioxin (1-MCDD).	dibenzo(1,4)dioxin	105-107	sallimus	Drosophila melanogaster	42-45
19167471-1	2009	This study investigates the dose-dependent expression of CYP1A1 and CYP1B1 in primary cultured bovine hepatocytes exposed to TCDD, several polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) congeners and fish oil used as animal feed ingredients to identify their dioxin-like potentials.	dibenzo(1,4)dioxin	154-171	cytochrome P450 1A1	Bos taurus	57-63
19167471-1	2009	This study investigates the dose-dependent expression of CYP1A1 and CYP1B1 in primary cultured bovine hepatocytes exposed to TCDD, several polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) congeners and fish oil used as animal feed ingredients to identify their dioxin-like potentials.	dibenzo(1,4)dioxin	154-171	cytochrome P450 1B1	Bos taurus	68-74
16834207-2	2005	The pi-pi* and n-pi* valence excited states of dibenzo-p-dioxin (DD) were studied via the complete active space SCF and multiconfigurational second-order perturbation theory employing the cc-pVDZ basis set and the full pi-electron active spaces of 16 electrons in 14 active orbitals.	dibenzo(1,4)dioxin	47-63	KIT ligand	Homo sapiens	112-115
16834207-2	2005	The pi-pi* and n-pi* valence excited states of dibenzo-p-dioxin (DD) were studied via the complete active space SCF and multiconfigurational second-order perturbation theory employing the cc-pVDZ basis set and the full pi-electron active spaces of 16 electrons in 14 active orbitals.	dibenzo(1,4)dioxin	65-67	KIT ligand	Homo sapiens	112-115
12464257-3	2003	Among four CYPs, rat CYP1A1 showed the highest activity toward dibenzo-p-dioxin (DD) and mono-, di-, and trichloroDDs.	dibenzo(1,4)dioxin	63-79	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	21-27
12464257-3	2003	Among four CYPs, rat CYP1A1 showed the highest activity toward dibenzo-p-dioxin (DD) and mono-, di-, and trichloroDDs.	dibenzo(1,4)dioxin	81-83	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	21-27
12207498-3	2002	Remarkable metabolism by the multiple CYP forms was observed toward dibenzo-p-dioxin (DD) and mono-, di-, and trichloroDDs.	dibenzo(1,4)dioxin	86-88	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	38-41
12207498-5	2002	Although major CYPs in human liver such as CYP2C8, CYP2C9, and CYP3A4 showed no significant metabolism toward the PCDDs, CYP1A1 and CYP1A2 showed high catalytic activity toward DD and mono-, di-, and trichloroDDs.	dibenzo(1,4)dioxin	116-118	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	132-138
8039542-1	1994	In an earlier study several hydroxylated polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) competitively displaced [125I]thyroxine (T4) from transthyretin with different potencies.	dibenzo(1,4)dioxin	75-92	transthyretin	Homo sapiens	177-190
12203118-1	2002	The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzofurans.	dibenzo(1,4)dioxin	180-197	aryl hydrocarbon receptor	Homo sapiens	4-28
12203118-1	2002	The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzofurans.	dibenzo(1,4)dioxin	180-197	aryl hydrocarbon receptor	Homo sapiens	30-33
9760282-1	1998	Earlier studies in our laboratory showed that hydroxylated metabolites of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) competitively inhibit thyroxine (T4) binding to transthyretin (TTR) and type I deiodinase (D1) activity.	dibenzo(1,4)dioxin	108-125	transthyretin	Rattus norvegicus	224-227
1510582-0	1992	Decreased hepatic phosphoenolpyruvate carboxykinase gene expression after 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment: implications for the acute toxicity of chlorinated dibenzo-p-dioxins in the rat.	dibenzo(1,4)dioxin	172-189	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	18-51
7907825-0	1994	Reduced activity of tryptophan 2,3-dioxygenase in the liver of rats treated with chlorinated dibenzo-p-dioxins (CDDs): dose-responses and structure-activity relationship.	dibenzo(1,4)dioxin	93-110	tryptophan 2,3-dioxygenase	Rattus norvegicus	20-46
7907825-1	1994	The activity of tryptophan 2,3-dioxygenase (TdO) was measured in the livers of male Sprague-Dawley rats after acutely toxic doses (LD20-LD80) of chlorinated dibenzo-p-dioxins (CDDs) with 4 of the up to 7 chlorine substituents occupying the 2,3,7,8-positions.	dibenzo(1,4)dioxin	157-174	tryptophan 2,3-dioxygenase	Rattus norvegicus	16-42
7907825-1	1994	The activity of tryptophan 2,3-dioxygenase (TdO) was measured in the livers of male Sprague-Dawley rats after acutely toxic doses (LD20-LD80) of chlorinated dibenzo-p-dioxins (CDDs) with 4 of the up to 7 chlorine substituents occupying the 2,3,7,8-positions.	dibenzo(1,4)dioxin	157-174	tryptophan 2,3-dioxygenase	Rattus norvegicus	44-47
2744682-7	1989	It has been reported that the AHH inducibility of Dioxins and Dibenzofurans correlates well with their toxic potency.	dibenzo(1,4)dioxin	50-57	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	30-33
1669971-2	1991	The group concluded that application of the TEF approach to PCBs would be less straightforward than it was in the case of chlorinated dibenzo-p-dioxins and dibenzofurans (CDDs/CDFs).	dibenzo(1,4)dioxin	134-151	TEF transcription factor, PAR bZIP family member	Homo sapiens	44-47
115836-1	1979	Induction of aryl hydrocarbon hydroxylase (AHH) activity in rat hepatoma cell line serves as a simple and rapid method to detect minute (pg) amounts of certain classes of compounds, e.g., dibenzo-p-dioxins, dibenzofurans, and biphenyls.	dibenzo(1,4)dioxin	188-205	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	13-41
19994994-0	1987	Polychlorinated Dibenzofurans and Dibenzo-p -dioxins and other Chlorinated Contaminants in Cow Milk from Various Locations in Switzerland.	dibenzo(1,4)dioxin	34-52	Weaning weight-maternal milk	Bos taurus	95-99
7203309-0	1980	Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin.	dibenzo(1,4)dioxin	88-104	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	25-53
115836-1	1979	Induction of aryl hydrocarbon hydroxylase (AHH) activity in rat hepatoma cell line serves as a simple and rapid method to detect minute (pg) amounts of certain classes of compounds, e.g., dibenzo-p-dioxins, dibenzofurans, and biphenyls.	dibenzo(1,4)dioxin	188-205	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	43-46
28922086-0	2017	Assessment of Ah receptor transcriptional activity mediated by halogenated dibenzo-p-dioxins and dibenzofurans (PXDD/Fs) in human and mouse cell systems.	dibenzo(1,4)dioxin	75-92	aryl hydrocarbon receptor	Homo sapiens	14-25
134910-8	1976	The correlation among the halogenated dibenzo-p-dioxins, between their potency as toxins and their potency as inducers of aryl hydrocarbon hydroxylase, is discussed in relationship to various proposed mechanisms of toxicity.	dibenzo(1,4)dioxin	38-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	122-150
31590087-5	2020	After comparison, the g-C3N4/NiO (4:6) showed optimal dechlorination performance such that 70.4% of 2-CDD was removed within 8 h and 52.3% of 2-CDD was transformed to dibenzo-p-dioxin (DD), about fourfold higher than the pristine g-C3N4.	dibenzo(1,4)dioxin	167-183	natriuretic peptide A	Homo sapiens	144-147
31681203-5	2019	Furthermore, the level of reactive oxygen species (ROS) in fungal protoplast was increased (3.1- to 3.8-fold) in response to TCDD exposure at 10 and 50 ng mL-1, respectively.	dibenzo(1,4)dioxin	125-129	L1 cell adhesion molecule	Mus musculus	155-159