PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27216364-13	2016	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-mu.	2-phenylacetylenesulfonamide	96-108	STE20 like kinase	Homo sapiens	39-42
27216364-13	2016	Conversely, the proapoptotic action of SLK was augmented by HSF1 shRNA, or the Hsp70 inhibitor, pifithrin-mu.	2-phenylacetylenesulfonamide	96-108	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-84
25111896-0	2014	Cell death induced by 2-phenylethynesulfonamide uncovers a pro-survival function of BAX.	2-phenylacetylenesulfonamide	22-47	BCL2-associated X protein	Mus musculus	84-87
25111896-1	2014	PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-micro.	2-phenylacetylenesulfonamide	0-3	transformation related protein 53, pseudogene	Mus musculus	76-79
25111896-1	2014	PES (2-phenylethynesulfonamide) was initially identified as an inhibitor of p53 translocation to mitochondria and named Pifithrin-micro.	2-phenylacetylenesulfonamide	5-30	transformation related protein 53, pseudogene	Mus musculus	76-79
22920900-4	2013	2-Phenylethynesulfonamide (PES) physically interacts with HSP70 and disrupts the association between HSP70 and several of its cofactors and client proteins, leading to cancer cell death that is selectively mediated through caspase-independent mechanisms involving increased protein aggregation, impairment of lysosomal functions, and inhibition of autophagy.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	58-63
25139326-0	2014	2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53.	2-phenylacetylenesulfonamide	0-25	tumor protein p53	Homo sapiens	94-97
25139326-0	2014	2-Phenylethynesulfonamide (PES) uncovers a necrotic process regulated by oxidative stress and p53.	2-phenylacetylenesulfonamide	27-30	tumor protein p53	Homo sapiens	94-97
25139326-7	2014	Genetically modified p53-null or p53 knocked-down cells show resistance to PES-driven necrosis.	2-phenylacetylenesulfonamide	75-78	tumor protein p53	Homo sapiens	21-24
25139326-7	2014	Genetically modified p53-null or p53 knocked-down cells show resistance to PES-driven necrosis.	2-phenylacetylenesulfonamide	75-78	tumor protein p53	Homo sapiens	33-36
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	138-141	tumor protein p53	Homo sapiens	63-66
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	138-141	tumor protein p53	Homo sapiens	111-114
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	138-141	tumor protein p53	Homo sapiens	111-114
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	220-223	tumor protein p53	Homo sapiens	63-66
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	220-223	tumor protein p53	Homo sapiens	111-114
25139326-9	2014	On the other hand, we report an augmented production of ROS in p53-positive cells that, added to the increased p53 content in response to PES-elicited ROS, suggests that p53 and ROS are mutually regulated in response to PES.	2-phenylacetylenesulfonamide	220-223	tumor protein p53	Homo sapiens	111-114
25026551-5	2014	In addition, AS-2 was less effective in preventing p53-mediated transcription-dependent events than pifithrin-mu (PFTmu), an inhibitor of transcription-independent apoptosis by p53.	2-phenylacetylenesulfonamide	114-119	transformation related protein 53, pseudogene	Mus musculus	177-180
23868063-0	2013	HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.	2-phenylacetylenesulfonamide	20-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
23868063-0	2013	HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma.	2-phenylacetylenesulfonamide	20-45	cathepsin D	Homo sapiens	64-75
23805318-0	2013	2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice.	2-phenylacetylenesulfonamide	0-25	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	126-130
23805318-0	2013	2-phenylethynesulfonamide Prevents Induction of Pro-inflammatory Factors and Attenuates LPS-induced Liver Injury by Targeting NHE1-Hsp70 Complex in Mice.	2-phenylacetylenesulfonamide	0-25	heat shock protein 1B	Mus musculus	131-136
23805318-5	2013	In this study, C57/BL6 mice were injected intraperitoneally with LPS and 2-phenylethynesulfonamide (PES), an inhibitor of Hsp70 substrate binding activity.	2-phenylacetylenesulfonamide	73-98	heat shock protein 1B	Mus musculus	122-127
23805318-5	2013	In this study, C57/BL6 mice were injected intraperitoneally with LPS and 2-phenylethynesulfonamide (PES), an inhibitor of Hsp70 substrate binding activity.	2-phenylacetylenesulfonamide	100-103	heat shock protein 1B	Mus musculus	122-127
23805318-7	2013	PES reduced inducible nitric oxide synthase (iNOS) protein expression as well as serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) content in LPS-stimulated mice; iii.	2-phenylacetylenesulfonamide	0-3	nitric oxide synthase 2, inducible	Mus musculus	12-43
23805318-7	2013	PES reduced inducible nitric oxide synthase (iNOS) protein expression as well as serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) content in LPS-stimulated mice; iii.	2-phenylacetylenesulfonamide	0-3	nitric oxide synthase 2, inducible	Mus musculus	45-49
23805318-7	2013	PES reduced inducible nitric oxide synthase (iNOS) protein expression as well as serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) content in LPS-stimulated mice; iii.	2-phenylacetylenesulfonamide	0-3	tumor necrosis factor	Mus musculus	135-144
24270669-0	2014	The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells.	2-phenylacetylenesulfonamide	25-50	cellular tumor antigen p53	Oncorhynchus mykiss	4-7
24270669-0	2014	The p53/HSP70 inhibitor, 2-phenylethynesulfonamide, causes oxidative stress, unfolded protein response and apoptosis in rainbow trout cells.	2-phenylacetylenesulfonamide	25-50	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	8-13
24270669-1	2014	The effect of 2-phenylethynesulfonamide (PES), which is a p53 and HSP70 inhibitor in mammalian cells, was studied on the rainbow trout (Oncorhynchus mykiss) gill epithelial cell line, RTgill-W1, in order to evaluate PES as a tool for understanding the cellular survival pathways operating in fish.	2-phenylacetylenesulfonamide	14-39	tumor protein p53	Homo sapiens	58-61
24270669-1	2014	The effect of 2-phenylethynesulfonamide (PES), which is a p53 and HSP70 inhibitor in mammalian cells, was studied on the rainbow trout (Oncorhynchus mykiss) gill epithelial cell line, RTgill-W1, in order to evaluate PES as a tool for understanding the cellular survival pathways operating in fish.	2-phenylacetylenesulfonamide	14-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	66-71
24270669-1	2014	The effect of 2-phenylethynesulfonamide (PES), which is a p53 and HSP70 inhibitor in mammalian cells, was studied on the rainbow trout (Oncorhynchus mykiss) gill epithelial cell line, RTgill-W1, in order to evaluate PES as a tool for understanding the cellular survival pathways operating in fish.	2-phenylacetylenesulfonamide	41-44	tumor protein p53	Homo sapiens	58-61
24270669-1	2014	The effect of 2-phenylethynesulfonamide (PES), which is a p53 and HSP70 inhibitor in mammalian cells, was studied on the rainbow trout (Oncorhynchus mykiss) gill epithelial cell line, RTgill-W1, in order to evaluate PES as a tool for understanding the cellular survival pathways operating in fish.	2-phenylacetylenesulfonamide	41-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	66-71
24270669-5	2014	HSP70 and BiP levels were higher in cultures treated with PES for 24h, but this was blocked by NAC.	2-phenylacetylenesulfonamide	58-61	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	0-5
24270669-8	2014	PES enhances the generation of ROS, possibly by inhibiting the anti-oxidant actions of p53 and HSP70.	2-phenylacetylenesulfonamide	0-3	cellular tumor antigen p53	Oncorhynchus mykiss	87-90
24270669-8	2014	PES enhances the generation of ROS, possibly by inhibiting the anti-oxidant actions of p53 and HSP70.	2-phenylacetylenesulfonamide	0-3	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	95-100
24270669-9	2014	ER stress arises from the ROS and from PES inhibiting the chaperone activities of HSP70.	2-phenylacetylenesulfonamide	39-42	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	82-87
23805318-7	2013	PES reduced inducible nitric oxide synthase (iNOS) protein expression as well as serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) content in LPS-stimulated mice; iii.	2-phenylacetylenesulfonamide	0-3	interleukin 6	Mus musculus	151-164
23805318-7	2013	PES reduced inducible nitric oxide synthase (iNOS) protein expression as well as serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) content in LPS-stimulated mice; iii.	2-phenylacetylenesulfonamide	0-3	interleukin 6	Mus musculus	166-170
23805318-8	2013	PES reduced the mRNA level of iNOS, TNF-alpha, and IL-6 in LPS-stimulated liver.	2-phenylacetylenesulfonamide	0-3	nitric oxide synthase 2, inducible	Mus musculus	30-34
23805318-8	2013	PES reduced the mRNA level of iNOS, TNF-alpha, and IL-6 in LPS-stimulated liver.	2-phenylacetylenesulfonamide	0-3	tumor necrosis factor	Mus musculus	36-45
23805318-8	2013	PES reduced the mRNA level of iNOS, TNF-alpha, and IL-6 in LPS-stimulated liver.	2-phenylacetylenesulfonamide	0-3	interleukin 6	Mus musculus	51-55
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	55-77
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	79-83
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	heat shock protein 1B	Mus musculus	100-105
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	163-167
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	heat shock protein 1B	Mus musculus	168-173
23805318-13	2013	Furthermore, PES significantly reduced the increase in Na(+)/H(+) exchanger 1 (NHE1) association to Hsp70 in LPS-stimulated macrophages and liver, suggesting that NHE1-Hsp70 interaction is required for the involvement of NHE1 in the inflammation response.	2-phenylacetylenesulfonamide	13-16	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	163-167
23303345-4	2013	Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical "lid" of this protein (amino acids 573-616) to bind.	2-phenylacetylenesulfonamide	41-66	heat shock protein 1B	Mus musculus	25-30
23303345-4	2013	Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical "lid" of this protein (amino acids 573-616) to bind.	2-phenylacetylenesulfonamide	41-66	heat shock protein 1B	Mus musculus	114-119
23303345-4	2013	Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical "lid" of this protein (amino acids 573-616) to bind.	2-phenylacetylenesulfonamide	68-71	heat shock protein 1B	Mus musculus	25-30
23303345-4	2013	Here, we report that the HSP70 inhibitor 2-phenylethynesulfonamide (PES) binds to the substrate-binding domain of HSP70 and requires the C-terminal helical "lid" of this protein (amino acids 573-616) to bind.	2-phenylacetylenesulfonamide	68-71	heat shock protein 1B	Mus musculus	114-119
22920900-4	2013	2-Phenylethynesulfonamide (PES) physically interacts with HSP70 and disrupts the association between HSP70 and several of its cofactors and client proteins, leading to cancer cell death that is selectively mediated through caspase-independent mechanisms involving increased protein aggregation, impairment of lysosomal functions, and inhibition of autophagy.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
22920900-4	2013	2-Phenylethynesulfonamide (PES) physically interacts with HSP70 and disrupts the association between HSP70 and several of its cofactors and client proteins, leading to cancer cell death that is selectively mediated through caspase-independent mechanisms involving increased protein aggregation, impairment of lysosomal functions, and inhibition of autophagy.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	58-63
22920900-4	2013	2-Phenylethynesulfonamide (PES) physically interacts with HSP70 and disrupts the association between HSP70 and several of its cofactors and client proteins, leading to cancer cell death that is selectively mediated through caspase-independent mechanisms involving increased protein aggregation, impairment of lysosomal functions, and inhibition of autophagy.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	101-106
21750704-5	2011	PFTmu, an inhibitor blocking p53 translocation to mitochondria, increased COX biogenesis in older mice, but not in young mice.	2-phenylacetylenesulfonamide	0-5	transformation related protein 53, pseudogene	Mus musculus	29-32
23006892-5	2012	Mechanically, PFTmu inhibited p53 translocation to mitochondria and thus increased its transcriptional activity for expression of synthesis of cytochrome c oxidase 2 (SCO2), an important assembly protein for COX.	2-phenylacetylenesulfonamide	14-19	transformation related protein 53, pseudogene	Mus musculus	30-33
23006892-5	2012	Mechanically, PFTmu inhibited p53 translocation to mitochondria and thus increased its transcriptional activity for expression of synthesis of cytochrome c oxidase 2 (SCO2), an important assembly protein for COX.	2-phenylacetylenesulfonamide	14-19	SCO2 cytochrome c oxidase assembly protein	Mus musculus	167-171
22474329-7	2012	This was confirmed by inhibition studies with PES (phenylethynesulfonamide), which disrupts inducible HSP70 function, and inhibited both inflammasomes and the adjuvant function.	2-phenylacetylenesulfonamide	51-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	102-107
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	26-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-116
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	26-51	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	53-56	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-116
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	53-56	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	175-178	heat shock protein family A (Hsp70) member 4	Homo sapiens	95-116
21738007-4	2011	We recently reported that 2-phenylethynesulfonamide (PES) selectively interacts with cytosolic heat shock protein 70 (HSP70) and inhibits its function; we further showed that PES promotes the death of tumor cells, and that this is associated with an impairment of lysosome function and an inhibition of autophagy.	2-phenylacetylenesulfonamide	175-178	heat shock protein family A (Hsp70) member 4	Homo sapiens	118-123
21738007-7	2011	We show that treatment of cells with PES blocks the trafficking of ARF to mitochondria, indicating that interaction with HSP70 mediates the mitochondrial localization of ARF.	2-phenylacetylenesulfonamide	37-40	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
21636681-0	2011	HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.	2-phenylacetylenesulfonamide	39-64	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
16862141-3	2006	To determine the impact of this p53 activity on normal tissue radiosensitivity, we isolated a small molecule named pifithrin-mu (PFTmu, 1) that inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.	2-phenylacetylenesulfonamide	129-134	transformation related protein 53, pseudogene	Mus musculus	32-35
19818706-3	2009	We have determined that a small molecule called 2-phenylethynesulfonamide (PES) interacts selectively with HSP70 and leads to a disruption of the association between HSP70 and several of its cochaperones and substrate proteins.	2-phenylacetylenesulfonamide	48-73	heat shock protein 1B	Mus musculus	107-112
19818706-3	2009	We have determined that a small molecule called 2-phenylethynesulfonamide (PES) interacts selectively with HSP70 and leads to a disruption of the association between HSP70 and several of its cochaperones and substrate proteins.	2-phenylacetylenesulfonamide	48-73	heat shock protein 1B	Mus musculus	166-171
19818706-3	2009	We have determined that a small molecule called 2-phenylethynesulfonamide (PES) interacts selectively with HSP70 and leads to a disruption of the association between HSP70 and several of its cochaperones and substrate proteins.	2-phenylacetylenesulfonamide	75-78	heat shock protein 1B	Mus musculus	107-112
19818706-3	2009	We have determined that a small molecule called 2-phenylethynesulfonamide (PES) interacts selectively with HSP70 and leads to a disruption of the association between HSP70 and several of its cochaperones and substrate proteins.	2-phenylacetylenesulfonamide	75-78	heat shock protein 1B	Mus musculus	166-171
16862141-3	2006	To determine the impact of this p53 activity on normal tissue radiosensitivity, we isolated a small molecule named pifithrin-mu (PFTmu, 1) that inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.	2-phenylacetylenesulfonamide	129-134	transformation related protein 53, pseudogene	Mus musculus	153-156
33835030-4	2021	PES (2-phenylethynesulfonamide or pifithrin-mu) has been reported to be an inhibitor of Hsp70.	2-phenylacetylenesulfonamide	5-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	88-93
34539881-14	2021	Pifithrin-mu (PFTmu, HSP70 inhibitor) decreased or removed the effects of peptide in increasing the sensitivity of ovarian cancer cells to DDP.	2-phenylacetylenesulfonamide	14-19	translocase of inner mitochondrial membrane 8A	Homo sapiens	139-142
34199046-7	2021	To prove that Hsp70 chaperone should be targeted when inhibiting the EMT pathway, we treated cancer cells with 2-phenylethynesulfonamide (PES) and demonstrated that the compound inhibited substrate-binding capacity of Hsp70.	2-phenylacetylenesulfonamide	111-136	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
34199046-7	2021	To prove that Hsp70 chaperone should be targeted when inhibiting the EMT pathway, we treated cancer cells with 2-phenylethynesulfonamide (PES) and demonstrated that the compound inhibited substrate-binding capacity of Hsp70.	2-phenylacetylenesulfonamide	111-136	heat shock protein family A (Hsp70) member 4	Homo sapiens	218-223
34199046-7	2021	To prove that Hsp70 chaperone should be targeted when inhibiting the EMT pathway, we treated cancer cells with 2-phenylethynesulfonamide (PES) and demonstrated that the compound inhibited substrate-binding capacity of Hsp70.	2-phenylacetylenesulfonamide	138-141	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
34199046-7	2021	To prove that Hsp70 chaperone should be targeted when inhibiting the EMT pathway, we treated cancer cells with 2-phenylethynesulfonamide (PES) and demonstrated that the compound inhibited substrate-binding capacity of Hsp70.	2-phenylacetylenesulfonamide	138-141	heat shock protein family A (Hsp70) member 4	Homo sapiens	218-223
16862141-3	2006	To determine the impact of this p53 activity on normal tissue radiosensitivity, we isolated a small molecule named pifithrin-mu (PFTmu, 1) that inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.	2-phenylacetylenesulfonamide	129-134	BCL2-like 1	Mus musculus	232-238
16862141-3	2006	To determine the impact of this p53 activity on normal tissue radiosensitivity, we isolated a small molecule named pifithrin-mu (PFTmu, 1) that inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.	2-phenylacetylenesulfonamide	129-134	B cell leukemia/lymphoma 2	Mus musculus	243-248
16862141-3	2006	To determine the impact of this p53 activity on normal tissue radiosensitivity, we isolated a small molecule named pifithrin-mu (PFTmu, 1) that inhibits p53 binding to mitochondria by reducing its affinity to antiapoptotic proteins Bcl-xL and Bcl-2 but has no effect on p53-dependent transactivation.	2-phenylacetylenesulfonamide	129-134	transformation related protein 53, pseudogene	Mus musculus	153-156
16862141-4	2006	PFTmu has a high specificity for p53 and does not protect cells from apoptosis induced by overexpression of proapoptotic protein Bax or by treatment with dexamethasone (2).	2-phenylacetylenesulfonamide	0-5	transformation related protein 53, pseudogene	Mus musculus	33-36
16862141-5	2006	PFTmu rescues primary mouse thymocytes from p53-mediated apoptosis caused by radiation and protects mice from doses of radiation that cause lethal hematopoietic syndrome.	2-phenylacetylenesulfonamide	0-5	transformation related protein 53, pseudogene	Mus musculus	44-47
31439619-1	2019	2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.	2-phenylacetylenesulfonamide	0-28	tumor protein p53	Homo sapiens	43-46
33455391-3	2020	Specifically, 2-phenylethynesulfonamide (PES), an inhibitor of heat shock protein 70 (HSP-70), was loaded into the NO nanogenerators to realize effective low-temperature (~45  C) PTT.	2-phenylacetylenesulfonamide	14-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-84
33455391-3	2020	Specifically, 2-phenylethynesulfonamide (PES), an inhibitor of heat shock protein 70 (HSP-70), was loaded into the NO nanogenerators to realize effective low-temperature (~45  C) PTT.	2-phenylacetylenesulfonamide	14-39	heat shock protein family A (Hsp70) member 4	Homo sapiens	86-92
33455391-3	2020	Specifically, 2-phenylethynesulfonamide (PES), an inhibitor of heat shock protein 70 (HSP-70), was loaded into the NO nanogenerators to realize effective low-temperature (~45  C) PTT.	2-phenylacetylenesulfonamide	41-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-84
33455391-3	2020	Specifically, 2-phenylethynesulfonamide (PES), an inhibitor of heat shock protein 70 (HSP-70), was loaded into the NO nanogenerators to realize effective low-temperature (~45  C) PTT.	2-phenylacetylenesulfonamide	41-44	heat shock protein family A (Hsp70) member 4	Homo sapiens	86-92
32110810-0	2020	2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	108-129
32110810-2	2020	2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-78
32110810-2	2020	2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	80-85
32110810-2	2020	2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	57-78
32110810-2	2020	2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	80-85
32110810-10	2020	Additionally, knockdown of Hsp70 enhanced the effects of PES.	2-phenylacetylenesulfonamide	57-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	27-32
32110810-13	2020	In conclusion, the present study demonstrated that PES suppresses the growth of OSCC cells through Hsp70-dependent mechanism.	2-phenylacetylenesulfonamide	51-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
30596969-12	2019	2-Phenylethynesulfonamide (PES), an HSP70 inhibitor, attenuated cardiac hypertrophy induced either by phenylephrine in neonatal ventricular cardiomyocytes or by aortic banding in mice.	2-phenylacetylenesulfonamide	0-25	heat shock protein 1B	Mus musculus	36-41
30596969-12	2019	2-Phenylethynesulfonamide (PES), an HSP70 inhibitor, attenuated cardiac hypertrophy induced either by phenylephrine in neonatal ventricular cardiomyocytes or by aortic banding in mice.	2-phenylacetylenesulfonamide	27-30	heat shock protein 1B	Mus musculus	36-41
30596969-13	2019	PES reduced HDAC2 S394 phosphorylation and its activation by interfering with the binding of HSP70 to HDAC2.	2-phenylacetylenesulfonamide	0-3	histone deacetylase 2	Mus musculus	12-17
30596969-13	2019	PES reduced HDAC2 S394 phosphorylation and its activation by interfering with the binding of HSP70 to HDAC2.	2-phenylacetylenesulfonamide	0-3	heat shock protein 1B	Mus musculus	93-98
30596969-13	2019	PES reduced HDAC2 S394 phosphorylation and its activation by interfering with the binding of HSP70 to HDAC2.	2-phenylacetylenesulfonamide	0-3	histone deacetylase 2	Mus musculus	102-107
31439619-1	2019	2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells.	2-phenylacetylenesulfonamide	30-33	tumor protein p53	Homo sapiens	43-46
27833016-0	2017	The small molecule 2-phenylethynesulfonamide induces covalent modification of p53.	2-phenylacetylenesulfonamide	19-44	tumor protein p53	Homo sapiens	78-81
32255036-3	2018	To overcome this issue, herein, for the first time, we have prepared an HSP70 inhibitor (2-phenylethynesulfonamide (PES))-loaded graphitic carbon nitride nanosheet (GCNS) as a multifunctional nanoplatform (GCNS-PES) for enhanced PDT.	2-phenylacetylenesulfonamide	89-114	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
32255036-3	2018	To overcome this issue, herein, for the first time, we have prepared an HSP70 inhibitor (2-phenylethynesulfonamide (PES))-loaded graphitic carbon nitride nanosheet (GCNS) as a multifunctional nanoplatform (GCNS-PES) for enhanced PDT.	2-phenylacetylenesulfonamide	116-119	heat shock protein family A (Hsp70) member 4	Homo sapiens	72-77
29959331-0	2018	The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70.	2-phenylacetylenesulfonamide	20-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	4-9
29959331-0	2018	The Hsp70 inhibitor 2-phenylethynesulfonamide inhibits replication and carcinogenicity of Epstein-Barr virus by inhibiting the molecular chaperone function of Hsp70.	2-phenylacetylenesulfonamide	20-45	heat shock protein family A (Hsp70) member 4	Homo sapiens	159-164
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	89-94
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	0-25	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	89-94
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
29959331-3	2018	2-phenylethynesulfonamide (PES) is a small molecular inhibitor of Heat shock protein 70 (Hsp70), which can interact with Hsp70 and disrupts its association with co-chaperones and substrate proteins of Hsp70.	2-phenylacetylenesulfonamide	27-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
28832998-9	2017	Pifithrin-mu, a selective inhibitor of p53 mitochondrial translocation, prevented the mitochondrial translocation of the p53 probe in a concentration-dependent manner.	2-phenylacetylenesulfonamide	0-12	tumor protein p53	Homo sapiens	39-42
28832998-9	2017	Pifithrin-mu, a selective inhibitor of p53 mitochondrial translocation, prevented the mitochondrial translocation of the p53 probe in a concentration-dependent manner.	2-phenylacetylenesulfonamide	0-12	tumor protein p53	Homo sapiens	121-124
27833016-2	2017	The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway.	2-phenylacetylenesulfonamide	19-44	tumor protein p53	Homo sapiens	97-100
27833016-2	2017	The small molecule 2-phenylethynesulfonamide (PES) was originally identified as the inhibitor of p53 effects on the mitochondrial death pathway.	2-phenylacetylenesulfonamide	46-49	tumor protein p53	Homo sapiens	97-100
27833016-3	2017	In this report we demonstrate that p53 protein from PES-treated cells was detected in reduced mobility bands between molecular weights 95-220 kDa.	2-phenylacetylenesulfonamide	52-55	tumor protein p53	Homo sapiens	35-38
28004121-2	2017	The small molecule 2-phenylethyenesulfonamide (PES), also referred to as pifithrin-mu, is known as an HSP70 inhibitor, which exhibits antitumor activities in a variety of cancer cell lines.	2-phenylacetylenesulfonamide	73-85	heat shock protein family A (Hsp70) member 4	Homo sapiens	102-107