PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34960104-0 2021 Tetrahydrocurcumin Upregulates the Adiponectin-AdipoR Pathway and Improves Insulin Signaling and Pancreatic beta-Cell Function in High-Fat Diet/Streptozotocin-Induced Diabetic Obese Mice. tetrahydrocurcumin 0-18 adiponectin, C1Q and collagen domain containing Mus musculus 35-46 34960104-5 2021 THC upregulated UCP-1 in adipose tissue and elevated adiponectin levels in the circulation. tetrahydrocurcumin 0-3 uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus 16-21 34960104-5 2021 THC upregulated UCP-1 in adipose tissue and elevated adiponectin levels in the circulation. tetrahydrocurcumin 0-3 adiponectin, C1Q and collagen domain containing Mus musculus 53-64 34960104-6 2021 THC upregulated the AdipoR1/R2-APPL1-mediated pathway in the liver and skeletal muscle, which contributes to improved insulin signaling, glucose utilization, and lipid metabolism. tetrahydrocurcumin 0-3 adiponectin receptor 1 Mus musculus 20-27 34960104-6 2021 THC upregulated the AdipoR1/R2-APPL1-mediated pathway in the liver and skeletal muscle, which contributes to improved insulin signaling, glucose utilization, and lipid metabolism. tetrahydrocurcumin 0-3 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Mus musculus 31-36 34960104-7 2021 Furthermore, THC treatment significantly (p < 0.05) preserved islet mass, reduced apoptosis, and restored defective insulin expression in the pancreatic beta-cells of diabetic obese mice, which was accompanied by an elevation of AdipoR1 and APPL1. tetrahydrocurcumin 13-16 adiponectin receptor 1 Mus musculus 229-236 34960104-7 2021 Furthermore, THC treatment significantly (p < 0.05) preserved islet mass, reduced apoptosis, and restored defective insulin expression in the pancreatic beta-cells of diabetic obese mice, which was accompanied by an elevation of AdipoR1 and APPL1. tetrahydrocurcumin 13-16 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 Mus musculus 241-246 34960104-8 2021 These results demonstrated a potential mechanism underlying the beneficial effects of THC against hyperglycemia via the adiponectin-AdipoR pathway, and thus, may lead to a novel therapeutic use for type 2 diabetes. tetrahydrocurcumin 86-89 adiponectin, C1Q and collagen domain containing Mus musculus 120-131 34555398-0 2021 Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways. tetrahydrocurcumin 28-46 AKT serine/threonine kinase 1 Rattus norvegicus 164-167 34187277-0 2021 Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway. tetrahydrocurcumin 0-18 sirtuin 1 Mus musculus 79-84 34187277-11 2021 Mechanistically, THC remarkably increased the expression of SIRT1, accompanied by decreased expressions of downstream molecules Ac-p65 and Ac-foxo1. tetrahydrocurcumin 17-20 sirtuin 1 Mus musculus 60-65 34187277-12 2021 Meanwhile, the beneficial effects of THC were clearly abolished by the SIRT1-specific inhibitor EX527. tetrahydrocurcumin 37-40 sirtuin 1 Mus musculus 71-76 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 sirtuin 1 Mus musculus 133-138 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 forkhead box O1 Mus musculus 209-224 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 catalase Mus musculus 278-281 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 peroxiredoxin 6 pseudogene 2 Mus musculus 315-318 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 interleukin 1 alpha Mus musculus 370-378 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 interleukin 1 beta Mus musculus 380-398 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 interleukin 6 Mus musculus 400-404 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 interleukin 6 Mus musculus 406-419 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 hepatitis A virus cellular receptor 1 Mus musculus 421-426 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 hepatitis A virus cellular receptor 1 Mus musculus 428-452 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 scruffy Mus musculus 476-479 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 sirtuin 1 Mus musculus 499-504 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 tumor necrosis factor Mus musculus 590-599 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 tumor necrosis factor Mus musculus 601-628 34187277-13 2021 These results delineate that THC prevents sepsis-induced AKI by suppressing inflammation and oxidative stress through activating the SIRT1 signaling.Abbreviation: Ac-p65: acetylated p65; Ac-foxo 1: acetylated forkhead box O1; AKI: acute kidney injury; BUN: blood urea nitrogen; CAT: catalase; DHE: dihydroethidium; GPx: glutathione peroxidase; GSH: reduced glutathione; IL-1beta: Interleukin-1 beta; IL-6: Interleukin-6; KIM-1: kidney injury molecule 1; MDA: malondialdehyde; SCr: serum creatinine; SIRT1: silent information regulator 1; SOD: superoxide dismutase; THC: tetrahydrocurcumin; TNF-alpha: tumor necrosis factor-alpha; TUNEL: TdT-mediated dUTP Nick-End Labeling; UAlb/Cr: urine micro albumin/creatinine. tetrahydrocurcumin 29-32 deoxynucleotidyltransferase, terminal Mus musculus 637-640 34555398-0 2021 Cardio-protective effect of tetrahydrocurcumin, the primary hydrogenated metabolite of curcumin in vivo and in vitro: Induction of apoptosis and autophagy via PI3K/AKT/mTOR pathways. tetrahydrocurcumin 28-46 mechanistic target of rapamycin kinase Rattus norvegicus 168-172 34555398-9 2021 THC effectively improved antioxidant activity by increasing SOD and CAT activities and decreasing MDA level. tetrahydrocurcumin 0-3 catalase Rattus norvegicus 68-71 34555398-10 2021 THC also enhanced mitochondrial membrane potential, inhibited apoptotic cell death, diminished the Bax/Bcl-2 ratio and cleaved caspase-3 level relative to the H/R model. tetrahydrocurcumin 0-3 BCL2 associated X, apoptosis regulator Rattus norvegicus 99-102 34555398-10 2021 THC also enhanced mitochondrial membrane potential, inhibited apoptotic cell death, diminished the Bax/Bcl-2 ratio and cleaved caspase-3 level relative to the H/R model. tetrahydrocurcumin 0-3 BCL2, apoptosis regulator Rattus norvegicus 103-108 34555398-10 2021 THC also enhanced mitochondrial membrane potential, inhibited apoptotic cell death, diminished the Bax/Bcl-2 ratio and cleaved caspase-3 level relative to the H/R model. tetrahydrocurcumin 0-3 caspase 3 Rattus norvegicus 127-136 34555398-11 2021 In addition, THC effectively decreased Beclin1 expression and LC3 II/LC3 I ratio, but increased p62 expression, compared with the H/R model group, and decreased the formation of H/R-induced autophagosomes and autolysosomes. tetrahydrocurcumin 13-16 beclin 1 Rattus norvegicus 39-46 34555398-11 2021 In addition, THC effectively decreased Beclin1 expression and LC3 II/LC3 I ratio, but increased p62 expression, compared with the H/R model group, and decreased the formation of H/R-induced autophagosomes and autolysosomes. tetrahydrocurcumin 13-16 microtubule-associated protein 1 light chain 3 alpha Rattus norvegicus 62-74 34555398-11 2021 In addition, THC effectively decreased Beclin1 expression and LC3 II/LC3 I ratio, but increased p62 expression, compared with the H/R model group, and decreased the formation of H/R-induced autophagosomes and autolysosomes. tetrahydrocurcumin 13-16 KH RNA binding domain containing, signal transduction associated 1 Rattus norvegicus 96-99 34555398-12 2021 Furthermore, THC promoted the phosphorylation of PI3K/AKT/mTOR and induced the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) after H/R. tetrahydrocurcumin 13-16 AKT serine/threonine kinase 1 Rattus norvegicus 54-57 34555398-12 2021 Furthermore, THC promoted the phosphorylation of PI3K/AKT/mTOR and induced the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) after H/R. tetrahydrocurcumin 13-16 mechanistic target of rapamycin kinase Rattus norvegicus 58-62 34555398-12 2021 Furthermore, THC promoted the phosphorylation of PI3K/AKT/mTOR and induced the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) after H/R. tetrahydrocurcumin 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 93-124 34555398-12 2021 Furthermore, THC promoted the phosphorylation of PI3K/AKT/mTOR and induced the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) after H/R. tetrahydrocurcumin 13-16 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 126-136 34555398-14 2021 In conclusion, THC effectively inhibited H/R-induced autophagy and apoptosis via, at least partially, activating the PI3K/AKT/mTOR pathways. tetrahydrocurcumin 15-18 AKT serine/threonine kinase 1 Rattus norvegicus 122-125 34555398-14 2021 In conclusion, THC effectively inhibited H/R-induced autophagy and apoptosis via, at least partially, activating the PI3K/AKT/mTOR pathways. tetrahydrocurcumin 15-18 mechanistic target of rapamycin kinase Rattus norvegicus 126-130 34428833-0 2021 Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth. tetrahydrocurcumin 0-18 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 39-44 34679727-8 2021 We observed that THC had similar binding capability and Abeta aggregation inhibition such as keto/enol Cur and it was greater than BDMC and DMC. tetrahydrocurcumin 17-20 amyloid beta (A4) precursor protein Mus musculus 56-61 34428833-4 2021 We found that THC significantly attenuated agonist-induced granule secretion in human gel-filtered platelets in vitro, including CD62P and CD63 expression and platelet factor 4, CCL5, and adenosine triphosphate release. tetrahydrocurcumin 14-17 selectin P Homo sapiens 129-134 34428833-4 2021 We found that THC significantly attenuated agonist-induced granule secretion in human gel-filtered platelets in vitro, including CD62P and CD63 expression and platelet factor 4, CCL5, and adenosine triphosphate release. tetrahydrocurcumin 14-17 CD63 molecule Homo sapiens 139-143 34428833-4 2021 We found that THC significantly attenuated agonist-induced granule secretion in human gel-filtered platelets in vitro, including CD62P and CD63 expression and platelet factor 4, CCL5, and adenosine triphosphate release. tetrahydrocurcumin 14-17 C-C motif chemokine ligand 5 Homo sapiens 178-182 34428833-5 2021 These inhibitory effects of THC were partially mediated by the attenuation of cytosolic phospholipase A2 (cPLA2) phosphorylation, leading to a decrease in thromboxane A2 (TxA2) generation. tetrahydrocurcumin 28-31 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 78-104 34428833-5 2021 These inhibitory effects of THC were partially mediated by the attenuation of cytosolic phospholipase A2 (cPLA2) phosphorylation, leading to a decrease in thromboxane A2 (TxA2) generation. tetrahydrocurcumin 28-31 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 106-111 34428833-6 2021 Moreover, the MAPK (Erk1/2, JNK1/2, and p38 MAPK) signaling pathways were downregulated by THC treatment, resulting in reduced cPLA2 activation, TxA2 generation, and granule secretion. tetrahydrocurcumin 91-94 mitogen-activated protein kinase 3 Mus musculus 20-26 34428833-6 2021 Moreover, the MAPK (Erk1/2, JNK1/2, and p38 MAPK) signaling pathways were downregulated by THC treatment, resulting in reduced cPLA2 activation, TxA2 generation, and granule secretion. tetrahydrocurcumin 91-94 mitogen-activated protein kinase 8 Mus musculus 28-34 34428833-6 2021 Moreover, the MAPK (Erk1/2, JNK1/2, and p38 MAPK) signaling pathways were downregulated by THC treatment, resulting in reduced cPLA2 activation, TxA2 generation, and granule secretion. tetrahydrocurcumin 91-94 mitogen-activated protein kinase 14 Mus musculus 40-48 34428833-6 2021 Moreover, the MAPK (Erk1/2, JNK1/2, and p38 MAPK) signaling pathways were downregulated by THC treatment, resulting in reduced cPLA2 activation, TxA2 generation, and granule secretion. tetrahydrocurcumin 91-94 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 127-132 34428833-10 2021 Thus, through inhibiting MAPKs/cPLA2 signaling, and attenuating platelet TxA2 generation, granule secretion, and thrombus formation, THC may be a potent cardioprotective agent. tetrahydrocurcumin 133-136 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 31-36 34243602-0 2021 Tetrahydrocurcumin ameliorates Alzheimer"s pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling. tetrahydrocurcumin 0-18 mitogen-activated protein kinase 1 Mus musculus 135-138 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 dopachrome tautomerase Mus musculus 306-334 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 tRNA proline 2 Mus musculus 336-341 34116562-7 2021 Both Cur and THC treatment could alter the compositions of the gut microbiota in asthmatic mice, characterized by a significant decrease in the ratio of Firmicutes to Bacteroidetes; Cur or THC supplementation also reduced the relative abundances of pro-inflammatory bacteria, e.g., Proteobacteria, Intestinimonas, Unidentified-Ruminococcaceae, and Lachnospiraceae, in OVA-induced mice. tetrahydrocurcumin 13-16 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 368-371 34116562-7 2021 Both Cur and THC treatment could alter the compositions of the gut microbiota in asthmatic mice, characterized by a significant decrease in the ratio of Firmicutes to Bacteroidetes; Cur or THC supplementation also reduced the relative abundances of pro-inflammatory bacteria, e.g., Proteobacteria, Intestinimonas, Unidentified-Ruminococcaceae, and Lachnospiraceae, in OVA-induced mice. tetrahydrocurcumin 189-192 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 368-371 34474516-10 2021 CONCLUSION: THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the intrarenal RAS/nicotinamide adenine dinucleotide phosphate oxidase IV (NOX4)/monocyte chemoattractant protein 1 (MCP-1) axis and by lowering the high SBP. tetrahydrocurcumin 12-15 NADPH oxidase 4 Mus musculus 197-201 34474516-10 2021 CONCLUSION: THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the intrarenal RAS/nicotinamide adenine dinucleotide phosphate oxidase IV (NOX4)/monocyte chemoattractant protein 1 (MCP-1) axis and by lowering the high SBP. tetrahydrocurcumin 12-15 chemokine (C-C motif) ligand 2 Mus musculus 203-237 34474516-10 2021 CONCLUSION: THU alleviated kidney injury in mice with HFD-induced type 2 diabetes, possibly by blunting the activation of the intrarenal RAS/nicotinamide adenine dinucleotide phosphate oxidase IV (NOX4)/monocyte chemoattractant protein 1 (MCP-1) axis and by lowering the high SBP. tetrahydrocurcumin 12-15 chemokine (C-C motif) ligand 2 Mus musculus 239-244 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 STAM binding protein Mus musculus 59-68 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 tyrosinase Mus musculus 246-256 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 tyrosinase Mus musculus 258-261 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 tyrosinase-related protein 1 Mus musculus 264-292 34452146-4 2021 It was demonstrated that THC could effectively inhibit the alpha-MSH (melanocyte-stimulating hormone) induced melanin production in B16F10 melanoma cells and the expressions of three key enzymes involved with the biosynthetic process of melanin, tyrosinase (TYR), tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2), were all significantly reduced. tetrahydrocurcumin 25-28 tyrosinase-related protein 1 Mus musculus 294-299 33425220-0 2020 Novel PGC-1alpha/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy. tetrahydrocurcumin 88-106 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 6-16 35214966-8 2022 The in vivo pharmacodynamics of THC-SLNs gel in 2,4-dinitrochlorobenzene (DNCB)-induced AD mice showed enhanced bioactivity; reduced levels of TNF-alpha and IL-6; and complete healing, as evident from histopathological studies. tetrahydrocurcumin 32-35 tumor necrosis factor Mus musculus 143-152 35214966-8 2022 The in vivo pharmacodynamics of THC-SLNs gel in 2,4-dinitrochlorobenzene (DNCB)-induced AD mice showed enhanced bioactivity; reduced levels of TNF-alpha and IL-6; and complete healing, as evident from histopathological studies. tetrahydrocurcumin 32-35 interleukin 6 Mus musculus 157-161 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 tumor necrosis factor Mus musculus 29-38 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 cytochrome b-245, beta polypeptide Mus musculus 40-44 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 NADPH oxidase 4 Mus musculus 46-50 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 71-74 34222477-8 2021 THC administration decreased TNF-alpha, Nox2, Nox4, and phosphorylated p65 levels and activated the Nrf2 pathway. tetrahydrocurcumin 0-3 nuclear factor, erythroid derived 2, like 2 Mus musculus 100-104 34222477-9 2021 Interestingly, THC administration suppressed the expression of the autophagy markers LC3, Atg5, and Beclin 1. tetrahydrocurcumin 15-18 microtubule-associated protein 1 light chain 3 alpha Mus musculus 85-88 34222477-9 2021 Interestingly, THC administration suppressed the expression of the autophagy markers LC3, Atg5, and Beclin 1. tetrahydrocurcumin 15-18 autophagy related 5 Mus musculus 90-94 34222477-9 2021 Interestingly, THC administration suppressed the expression of the autophagy markers LC3, Atg5, and Beclin 1. tetrahydrocurcumin 15-18 beclin 1, autophagy related Mus musculus 100-108 33425220-0 2020 Novel PGC-1alpha/ATF5 Axis Partly Activates UPRmt and Mediates Cardioprotective Role of Tetrahydrocurcumin in Pathological Cardiac Hypertrophy. tetrahydrocurcumin 88-106 activating transcription factor 5 Mus musculus 17-21 33425220-9 2020 Furthermore, PGC-1alpha knockdown blunted the UPRmt activation and the cardioprotective role of THC. tetrahydrocurcumin 96-99 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 13-23 33425220-13 2020 The PGC-1alpha/ATF5 axis mediated the UPRmt activation and stress-resistance role of THC in vitro. tetrahydrocurcumin 85-88 PPARG coactivator 1 alpha Rattus norvegicus 4-14 33425220-13 2020 The PGC-1alpha/ATF5 axis mediated the UPRmt activation and stress-resistance role of THC in vitro. tetrahydrocurcumin 85-88 activating transcription factor 5 Rattus norvegicus 15-19 33425220-14 2020 Collectively, the present study provides the first evidence that PGC-1 and ATF5 can form a signaling axis to partly activate UPRmt that mediates the cardioprotective role of THC in pathological cardiac hypertrophy. tetrahydrocurcumin 174-177 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 65-70 33425220-14 2020 Collectively, the present study provides the first evidence that PGC-1 and ATF5 can form a signaling axis to partly activate UPRmt that mediates the cardioprotective role of THC in pathological cardiac hypertrophy. tetrahydrocurcumin 174-177 activating transcription factor 5 Rattus norvegicus 75-79 33424997-5 2020 The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS. tetrahydrocurcumin 31-34 mast cell protease 1 Mus musculus 96-101 33424997-5 2020 The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS. tetrahydrocurcumin 31-34 mast cell protease 1 Mus musculus 136-141 33424997-5 2020 The results revealed that CUR, THC, and OHC dose-dependently inhibited the generation of NO and MCP-1 as well as the gene expression of MCP-1 and iNOS. tetrahydrocurcumin 31-34 nitric oxide synthase 2, inducible Mus musculus 146-150 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 56-65 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 glutamate-cysteine ligase, catalytic subunit Mus musculus 192-196 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 glutamate-cysteine ligase, modifier subunit Mus musculus 202-206 33424997-8 2020 These results demonstrated that CUR, THC, and OHC exerted beneficial effect on LPS-stimulated inflammatory and oxidative responses, at least partially, through inhibiting the NF-kappaB and MAPKs pathways and activating Nrf2-regulated antioxidant gene expression. tetrahydrocurcumin 37-40 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 175-184 33424997-8 2020 These results demonstrated that CUR, THC, and OHC exerted beneficial effect on LPS-stimulated inflammatory and oxidative responses, at least partially, through inhibiting the NF-kappaB and MAPKs pathways and activating Nrf2-regulated antioxidant gene expression. tetrahydrocurcumin 37-40 nuclear factor, erythroid derived 2, like 2 Mus musculus 219-223 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 mitogen-activated protein kinase 14 Mus musculus 81-88 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 mitogen-activated protein kinase 1 Mus musculus 93-96 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 nuclear factor, erythroid derived 2, like 2 Mus musculus 150-154 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 heme oxygenase 1 Mus musculus 179-183 33424997-6 2020 Additionally, CUR, THC, and OHC significantly inhibited NF-kappaB activation and p38MAPK and ERK phosphorylation, while substantially upregulated the Nrf2 target gene expression (HO-1, NQO-1, GCLC, and GCLM). tetrahydrocurcumin 19-22 NAD(P)H dehydrogenase, quinone 1 Mus musculus 185-190 32767918-0 2021 Comparative Inhibitory Efficacy on the iNOS/NO System of Curcumin- and Tetrahydrocurcumin-Self-Microemulsifying Liquid Formulation in Chronic Gastric Ulcer Model. tetrahydrocurcumin 71-89 nitric oxide synthase 2 Rattus norvegicus 39-43 32573860-0 2020 Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-kappaB/VEGF/MMP-9 pathway. tetrahydrocurcumin 0-18 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 106-115 32573860-0 2020 Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-kappaB/VEGF/MMP-9 pathway. tetrahydrocurcumin 0-18 vascular endothelial growth factor A Mus musculus 116-120 32573860-0 2020 Tetrahydrocurcumin mitigates acute hypobaric hypoxia-induced cerebral oedema and inflammation through the NF-kappaB/VEGF/MMP-9 pathway. tetrahydrocurcumin 0-18 matrix metallopeptidase 9 Mus musculus 121-126 32573860-3 2020 Our results revealed that prophylactic administration of THC (40 mg/kg) for 3 days significantly alleviated the increase in brain water content (BWC), interleukin-1beta (IL-1beta) and TNF-alpha levels caused by acute hypobaric hypoxia (AHH). tetrahydrocurcumin 57-60 interleukin 1 beta Mus musculus 151-168 32573860-3 2020 Our results revealed that prophylactic administration of THC (40 mg/kg) for 3 days significantly alleviated the increase in brain water content (BWC), interleukin-1beta (IL-1beta) and TNF-alpha levels caused by acute hypobaric hypoxia (AHH). tetrahydrocurcumin 57-60 interleukin 1 alpha Mus musculus 170-178 32573860-3 2020 Our results revealed that prophylactic administration of THC (40 mg/kg) for 3 days significantly alleviated the increase in brain water content (BWC), interleukin-1beta (IL-1beta) and TNF-alpha levels caused by acute hypobaric hypoxia (AHH). tetrahydrocurcumin 57-60 tumor necrosis factor Mus musculus 184-193 32573860-7 2020 Furthermore, THC administration remarkably downregulated VEGF, matrix metallopeptidase-9 (MMP-9), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) expression, both in vivo and in vitro. tetrahydrocurcumin 13-16 vascular endothelial growth factor A Mus musculus 57-61 32573860-7 2020 Furthermore, THC administration remarkably downregulated VEGF, matrix metallopeptidase-9 (MMP-9), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) expression, both in vivo and in vitro. tetrahydrocurcumin 13-16 matrix metallopeptidase 9 Mus musculus 63-88 32573860-7 2020 Furthermore, THC administration remarkably downregulated VEGF, matrix metallopeptidase-9 (MMP-9), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) expression, both in vivo and in vitro. tetrahydrocurcumin 13-16 matrix metallopeptidase 9 Mus musculus 90-95 32573860-7 2020 Furthermore, THC administration remarkably downregulated VEGF, matrix metallopeptidase-9 (MMP-9), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) expression, both in vivo and in vitro. tetrahydrocurcumin 13-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 166-175 32573860-8 2020 Our data highlight the potential prophylactic activity of THC in HACE, it effectively mitigates AHH-induced cerebral oedema and inflammation is associated with the inhibition of the NF-kappaB/ VEGF/MMP-9 pathways. tetrahydrocurcumin 58-61 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 182-191 32573860-8 2020 Our data highlight the potential prophylactic activity of THC in HACE, it effectively mitigates AHH-induced cerebral oedema and inflammation is associated with the inhibition of the NF-kappaB/ VEGF/MMP-9 pathways. tetrahydrocurcumin 58-61 vascular endothelial growth factor A Mus musculus 193-197 32573860-8 2020 Our data highlight the potential prophylactic activity of THC in HACE, it effectively mitigates AHH-induced cerebral oedema and inflammation is associated with the inhibition of the NF-kappaB/ VEGF/MMP-9 pathways. tetrahydrocurcumin 58-61 matrix metallopeptidase 9 Mus musculus 198-203 32531320-0 2020 Tetrahydrocurcumin ameliorates diabetes profiles of db/db mice by altering the composition of gut microbiota and up-regulating the expression of GLP-1 in the pancreas. tetrahydrocurcumin 0-18 glucagon Mus musculus 145-150 32531320-4 2020 In the research, we investigated whether THC could improve diabetes by regulating the gut microbiota and the expression of pancreatic glucagon-like peptide-1 (GLP-1) in the db/db mice. tetrahydrocurcumin 41-44 glucagon Mus musculus 134-157 32531320-4 2020 In the research, we investigated whether THC could improve diabetes by regulating the gut microbiota and the expression of pancreatic glucagon-like peptide-1 (GLP-1) in the db/db mice. tetrahydrocurcumin 41-44 glucagon Mus musculus 159-164 32531320-7 2020 Compared to the diabetic group, THC treatment decreased significantly blood glucose, increased the secretion of insulin and the expression of GLP-1 in the pancreas. tetrahydrocurcumin 32-35 glucagon Mus musculus 142-147 32531320-11 2020 Altogether, these results demonstrated that THC might have a direct regulatory effect on gut microflora, which indirectly decrease the FBG levels by modulating GLP-1 expression in the pancreas. tetrahydrocurcumin 44-47 glucagon Mus musculus 160-165 32767918-5 2021 OBJECTIVE: This study aimed to evaluate and compare antiulcer efficacy of curcumin- and THC-SMEDDS through inhibition of the iNOS/NO system in rat model. tetrahydrocurcumin 88-91 nitric oxide synthase 2 Rattus norvegicus 125-129 32767918-8 2021 SMEDDS used in the study significantly increased the inhibitory efficacy of THC on iNOS/NO production and iNOS mRNA expression into a comparable inhibitory potency to that of curcumin. tetrahydrocurcumin 76-79 nitric oxide synthase 2 Rattus norvegicus 83-87 32923007-0 2020 Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities. tetrahydrocurcumin 43-61 desmocollin 3 Homo sapiens 81-84 32923007-0 2020 Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities. tetrahydrocurcumin 43-61 T-box transcription factor 1 Homo sapiens 86-89 32923007-7 2020 THC was thermally stable up to 335.55 C. THC exhibited more suppression of cytokines (TNF-alpha, IL-1beta, and MIP-1alpha) than CUR in a concentration-dependent manner in mouse splenocytes, while NK-cell and phagocytosis activity was increased in macrophages. tetrahydrocurcumin 0-3 tumor necrosis factor Mus musculus 87-96 32923007-7 2020 THC was thermally stable up to 335.55 C. THC exhibited more suppression of cytokines (TNF-alpha, IL-1beta, and MIP-1alpha) than CUR in a concentration-dependent manner in mouse splenocytes, while NK-cell and phagocytosis activity was increased in macrophages. tetrahydrocurcumin 0-3 chemokine (C-C motif) ligand 3 Mus musculus 112-122 32923007-7 2020 THC was thermally stable up to 335.55 C. THC exhibited more suppression of cytokines (TNF-alpha, IL-1beta, and MIP-1alpha) than CUR in a concentration-dependent manner in mouse splenocytes, while NK-cell and phagocytosis activity was increased in macrophages. tetrahydrocurcumin 42-45 tumor necrosis factor Mus musculus 87-96 32923007-7 2020 THC was thermally stable up to 335.55 C. THC exhibited more suppression of cytokines (TNF-alpha, IL-1beta, and MIP-1alpha) than CUR in a concentration-dependent manner in mouse splenocytes, while NK-cell and phagocytosis activity was increased in macrophages. tetrahydrocurcumin 42-45 interleukin 1 alpha Mus musculus 98-106 32923007-7 2020 THC was thermally stable up to 335.55 C. THC exhibited more suppression of cytokines (TNF-alpha, IL-1beta, and MIP-1alpha) than CUR in a concentration-dependent manner in mouse splenocytes, while NK-cell and phagocytosis activity was increased in macrophages. tetrahydrocurcumin 42-45 chemokine (C-C motif) ligand 3 Mus musculus 112-122 32923007-8 2020 THC showed a significant reduction of free radicals (LPO) along with improved antioxidant enzymes (SOD and catalase) and increased free radical scavenging activity against ABTS+ radicals in HepG2 cells. tetrahydrocurcumin 0-3 superoxide dismutase 1 Homo sapiens 99-115 30900133-6 2019 It was found that THC exhibited equivalent gp120-CD4 binding inhibitory activity as compared with curcumin due to its stable hydrophobic interactions with residues Asp368 and Trp427 deeper in the Phe43 cavity of CD4 receptor. tetrahydrocurcumin 18-21 CD4 molecule Homo sapiens 49-52 31905820-9 2019 Western blot analysis indicated that the phosphorylation of mitogen-activated protein kinases including c-Jun N-terminal kinase, extracellular signal-related kinases 1/2, and p38 by glutamate was significantly diminished by treatment with THC. tetrahydrocurcumin 239-242 mitogen-activated protein kinase 14 Mus musculus 175-178 32784298-9 2020 Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). tetrahydrocurcumin 86-89 interleukin 4 Mus musculus 257-261 32784298-9 2020 Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). tetrahydrocurcumin 86-89 interleukin 5 Mus musculus 263-267 32784298-9 2020 Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). tetrahydrocurcumin 86-89 interleukin 17A Mus musculus 273-279 31602247-0 2019 Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. tetrahydrocurcumin 0-18 forkhead box O4 Rattus norvegicus 112-117 31602247-4 2019 Furthermore, oxidative stress and apoptosis (caspase-3 activity and B-cell lymphoma 2-associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. tetrahydrocurcumin 161-179 caspase 3 Rattus norvegicus 45-54 31602247-5 2019 Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. tetrahydrocurcumin 0-18 matrix metallopeptidase 3 Rattus norvegicus 64-98 31602247-5 2019 Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase-3 and -13, as well as cyclooxygenase-2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. tetrahydrocurcumin 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 161-164 31602247-6 2019 The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats. tetrahydrocurcumin 34-52 forkhead box O4 Rattus norvegicus 135-140 31030375-10 2019 Curcumin or THC complexes in HP-CDs with improved bioavailability also induced anti-oxidant activity (SOD1, CAT1, and HMOX1) in higher levels in the ocular epithelial cells and showed oxidative protection effects in rabbit cornea tissues that will boost up their application in ocular medicine. tetrahydrocurcumin 12-15 superoxide dismutase [Cu-Zn] Oryctolagus cuniculus 102-106 31030375-10 2019 Curcumin or THC complexes in HP-CDs with improved bioavailability also induced anti-oxidant activity (SOD1, CAT1, and HMOX1) in higher levels in the ocular epithelial cells and showed oxidative protection effects in rabbit cornea tissues that will boost up their application in ocular medicine. tetrahydrocurcumin 12-15 heme oxygenase 1 Oryctolagus cuniculus 118-123 30900133-5 2019 To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding. tetrahydrocurcumin 23-41 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 198-203 30900133-5 2019 To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding. tetrahydrocurcumin 23-41 CD4 molecule Homo sapiens 204-207 30900133-5 2019 To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding. tetrahydrocurcumin 43-46 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 198-203 30900133-5 2019 To address this issue, tetrahydrocurcumin (THC), a colorless derivative of curcumin, was subjected to in silico screening (molecular docking and dynamics simulation studies) using homology model of gp120-CD4 binding. tetrahydrocurcumin 43-46 CD4 molecule Homo sapiens 204-207 30900133-6 2019 It was found that THC exhibited equivalent gp120-CD4 binding inhibitory activity as compared with curcumin due to its stable hydrophobic interactions with residues Asp368 and Trp427 deeper in the Phe43 cavity of CD4 receptor. tetrahydrocurcumin 18-21 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 43-48 30900133-6 2019 It was found that THC exhibited equivalent gp120-CD4 binding inhibitory activity as compared with curcumin due to its stable hydrophobic interactions with residues Asp368 and Trp427 deeper in the Phe43 cavity of CD4 receptor. tetrahydrocurcumin 18-21 CD4 molecule Homo sapiens 212-224 30423402-0 2019 Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway. tetrahydrocurcumin 0-18 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 197-203 31210844-0 2019 Tetrahydrocurcumin Ameliorates Diabetic Cardiomyopathy by Attenuating High Glucose-Induced Oxidative Stress and Fibrosis via Activating the SIRT1 Pathway. tetrahydrocurcumin 0-18 sirtuin 1 Mus musculus 140-145 31210844-5 2019 Mechanically, THC administration remarkably increased the expression of the SIRT1 signaling pathway both in vitro and in vivo, further evidenced by decreased downstream molecule Ac-SOD2 and enhanced deacetylated production SOD2, which finally strengthened antioxidative stress capacity proven by repaired activities of SOD and GSH-Px and reduced MDA production. tetrahydrocurcumin 14-17 sirtuin 1 Mus musculus 76-81 31210844-5 2019 Mechanically, THC administration remarkably increased the expression of the SIRT1 signaling pathway both in vitro and in vivo, further evidenced by decreased downstream molecule Ac-SOD2 and enhanced deacetylated production SOD2, which finally strengthened antioxidative stress capacity proven by repaired activities of SOD and GSH-Px and reduced MDA production. tetrahydrocurcumin 14-17 superoxide dismutase 2, mitochondrial Mus musculus 181-185 31210844-5 2019 Mechanically, THC administration remarkably increased the expression of the SIRT1 signaling pathway both in vitro and in vivo, further evidenced by decreased downstream molecule Ac-SOD2 and enhanced deacetylated production SOD2, which finally strengthened antioxidative stress capacity proven by repaired activities of SOD and GSH-Px and reduced MDA production. tetrahydrocurcumin 14-17 superoxide dismutase 2, mitochondrial Mus musculus 223-227 31210844-6 2019 Additionally, THC treatment accomplished its antifibrotic effect by depressing the ROS-induced TGFbeta1/Smad3 signaling pathway followed by reduced expression of cardiac fibrotic markers alpha-SMA, collagen I, and collagen III. tetrahydrocurcumin 14-17 transforming growth factor, beta 1 Mus musculus 95-103 31210844-6 2019 Additionally, THC treatment accomplished its antifibrotic effect by depressing the ROS-induced TGFbeta1/Smad3 signaling pathway followed by reduced expression of cardiac fibrotic markers alpha-SMA, collagen I, and collagen III. tetrahydrocurcumin 14-17 SMAD family member 3 Mus musculus 104-109 31210844-6 2019 Additionally, THC treatment accomplished its antifibrotic effect by depressing the ROS-induced TGFbeta1/Smad3 signaling pathway followed by reduced expression of cardiac fibrotic markers alpha-SMA, collagen I, and collagen III. tetrahydrocurcumin 14-17 actin alpha 2, smooth muscle, aorta Mus musculus 187-196 31210844-7 2019 Collectively, these finds demonstrated the therapeutic potential of THC treatment to alleviate DCM mainly by attenuating hyperglycemia-induced oxidative stress and fibrosis via activating the SIRT1 pathway. tetrahydrocurcumin 68-71 sirtuin 1 Mus musculus 192-197 30816509-5 2019 Curcumin sulfate was transported by all three OATPs, although to a much lesser extent, while uptake of tetrahydrocurcumin was the highest but only via OATP1B1 and OATP1B3. tetrahydrocurcumin 103-121 solute carrier organic anion transporter family member 1B3 Homo sapiens 163-170 30816509-7 2019 The increased mRNA levels of OATP1B1 in wild-type human breast cancer ZR-75-1 cells compared with OATP1B1 knockdown cells was associated with a higher initial uptake of curcumin and tetrahydrocurcumin leading to decreased IC50 values. tetrahydrocurcumin 182-200 solute carrier organic anion transporter family member 1B1 Homo sapiens 29-36 30816509-7 2019 The increased mRNA levels of OATP1B1 in wild-type human breast cancer ZR-75-1 cells compared with OATP1B1 knockdown cells was associated with a higher initial uptake of curcumin and tetrahydrocurcumin leading to decreased IC50 values. tetrahydrocurcumin 182-200 solute carrier organic anion transporter family member 1B1 Homo sapiens 98-105 30423402-0 2019 Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway. tetrahydrocurcumin 0-18 kelch like ECH associated protein 1 Homo sapiens 208-213 30423402-0 2019 Tetrahydrocurcumin and octahydrocurcumin, the primary and final hydrogenated metabolites of curcumin, possess superior hepatic-protective effect against acetaminophen-induced liver injury: Role of CYP2E1 and Keap1-Nrf2 pathway. tetrahydrocurcumin 0-18 NFE2 like bZIP transcription factor 2 Homo sapiens 214-218 30423402-4 2019 Our results showed that OHC and THC dose-dependently enhanced liver function (ALT and AST levels) and alleviated histopathological deterioration. tetrahydrocurcumin 32-35 solute carrier family 17 member 5 Homo sapiens 86-89 30423402-6 2019 In addition, OHC and THC markedly suppressed the activity and expressions of CYP2E1, and bound to the active sites of CYP2E1. tetrahydrocurcumin 21-24 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 77-83 30423402-6 2019 In addition, OHC and THC markedly suppressed the activity and expressions of CYP2E1, and bound to the active sites of CYP2E1. tetrahydrocurcumin 21-24 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 118-124 30423402-9 2019 In conclusion, OHC and THC possess favorable hepato-protective effect through restoring antioxidant status, inhibiting CYP2E1 and activating Keap1-Nrf2 pathway, which might represent promising antioxidants for the treatment of APAP-induced hepatotoxicity. tetrahydrocurcumin 23-26 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 119-125 30423402-9 2019 In conclusion, OHC and THC possess favorable hepato-protective effect through restoring antioxidant status, inhibiting CYP2E1 and activating Keap1-Nrf2 pathway, which might represent promising antioxidants for the treatment of APAP-induced hepatotoxicity. tetrahydrocurcumin 23-26 kelch like ECH associated protein 1 Homo sapiens 141-146 30423402-9 2019 In conclusion, OHC and THC possess favorable hepato-protective effect through restoring antioxidant status, inhibiting CYP2E1 and activating Keap1-Nrf2 pathway, which might represent promising antioxidants for the treatment of APAP-induced hepatotoxicity. tetrahydrocurcumin 23-26 NFE2 like bZIP transcription factor 2 Homo sapiens 147-151 29492979-10 2018 CONCLUSIONS: Tetrahydrocurcumin can synergistically enhance the radiosensitivity of glioma cells by inhibiting the expressions of cyclin D1 and PCNA. tetrahydrocurcumin 13-31 cyclin D1 Mus musculus 130-139 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 heart and neural crest derivatives expressed 2 Mus musculus 108-111 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 interleukin 4 receptor, alpha Mus musculus 141-151 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 Janus kinase 1 Mus musculus 152-156 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 signal transducer and activator of transcription 6 Mus musculus 157-162 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 jagged 1 Mus musculus 167-174 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 jagged 2 Mus musculus 175-182 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 notch 1 Mus musculus 184-190 30137697-0 2018 Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice. tetrahydrocurcumin 0-18 notch 2 Mus musculus 191-197 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 heart and neural crest derivatives expressed 2 Mus musculus 265-268 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 interleukin 4 receptor, alpha Mus musculus 289-299 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 Janus kinase 1 Mus musculus 300-304 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 signal transducer and activator of transcription 6 Mus musculus 305-310 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 jagged 1 Mus musculus 315-322 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 jagged 2 Mus musculus 323-330 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 notch 1 Mus musculus 331-337 30137697-8 2018 RESULTS: Both THC and Cur had beneficial effects on asthmatic mice with regard to nasal symptoms, pathological changes (eosinophils and mucus hyper-production), oxidative stress (malondialdehyde), cytokine production (IL-13), Th17 and cytotoxic T cell subsets, and Th2 signalling pathway (IL-4Ralpha-Jak1-STAT6 and Jagged1/Jagged2-Notch1/Notch2 axis) activity. tetrahydrocurcumin 14-17 notch 2 Mus musculus 338-344 30137697-9 2018 THC was more effective than Cur in suppressing tissue eosinophilia, mucus production, and IL-4Ralpha/Jak1/STAT6 pathway activity. tetrahydrocurcumin 0-3 interleukin 4 receptor, alpha Mus musculus 90-100 30137697-9 2018 THC was more effective than Cur in suppressing tissue eosinophilia, mucus production, and IL-4Ralpha/Jak1/STAT6 pathway activity. tetrahydrocurcumin 0-3 Janus kinase 1 Mus musculus 101-105 30137697-9 2018 THC was more effective than Cur in suppressing tissue eosinophilia, mucus production, and IL-4Ralpha/Jak1/STAT6 pathway activity. tetrahydrocurcumin 0-3 signal transducer and activator of transcription 6 Mus musculus 106-111 30137697-10 2018 Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL-4 and IL-5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione). tetrahydrocurcumin 18-21 heart and neural crest derivatives expressed 2 Mus musculus 62-65 30137697-10 2018 Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL-4 and IL-5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione). tetrahydrocurcumin 18-21 interleukin 4 Mus musculus 77-81 30137697-10 2018 Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL-4 and IL-5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione). tetrahydrocurcumin 18-21 interleukin 5 Mus musculus 86-90 30137697-10 2018 Furthermore, only THC inhibited peripheral eosinophil levels, Th2 cytokines (IL-4 and IL-5), and Th2 cell subsets and enhanced an antioxidant enzyme (glutathione). tetrahydrocurcumin 18-21 heart and neural crest derivatives expressed 2 Mus musculus 97-100 30137697-11 2018 CONCLUSION AND CLINICAL RELEVANCE: The above results demonstrated for the first time that THC was superior to Cur in modulating allergic asthmatic phenotypes, especially attenuating the Th2 response. tetrahydrocurcumin 90-93 heart and neural crest derivatives expressed 2 Mus musculus 186-189 30401410-13 2018 The streptozocin-treated INS-1 cell produced significantly higher levels of and B-cell lymphoma-2-associated X protein, caspase-3, and caspase-9 than INS-1 treated with THC. tetrahydrocurcumin 169-172 insulin 1 Rattus norvegicus 25-30 30401411-9 2018 The effect of apoptosis by THC in LLC-PK1 cells was determined by measuring the caspase-9, caspase-3, B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X protein levels using Western blotting analyses. tetrahydrocurcumin 27-30 caspase 9 Sus scrofa 80-89 30401411-9 2018 The effect of apoptosis by THC in LLC-PK1 cells was determined by measuring the caspase-9, caspase-3, B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X protein levels using Western blotting analyses. tetrahydrocurcumin 27-30 caspase 3 Sus scrofa 91-119 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 prostaglandin-endoperoxide synthase 2 Mus musculus 106-122 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 prostaglandin-endoperoxide synthase 2 Mus musculus 124-129 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 147-168 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 170-179 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 mitogen-activated protein kinase kinase kinase 7 Mus musculus 194-244 30386242-5 2018 Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-kappaB (NF-kappaB) pathways via transforming growth factor beta activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model. tetrahydrocurcumin 10-13 mitogen-activated protein kinase kinase kinase 7 Mus musculus 246-250 30401411-9 2018 The effect of apoptosis by THC in LLC-PK1 cells was determined by measuring the caspase-9, caspase-3, B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X protein levels using Western blotting analyses. tetrahydrocurcumin 27-30 apoptosis regulator Bcl-2 Sus scrofa 133-138 30401411-13 2018 Apoptosis was significantly decreased, and Bcl-2 was elevated in the THC-treated group. tetrahydrocurcumin 69-72 apoptosis regulator Bcl-2 Sus scrofa 43-48 30401411-14 2018 Bcl-2-associated X protein, caspase-3, and caspase-9 were decreased in the THC-treated group. tetrahydrocurcumin 75-78 apoptosis regulator Bcl-2 Sus scrofa 0-5 30401411-14 2018 Bcl-2-associated X protein, caspase-3, and caspase-9 were decreased in the THC-treated group. tetrahydrocurcumin 75-78 caspase 3 Sus scrofa 28-37 30401411-14 2018 Bcl-2-associated X protein, caspase-3, and caspase-9 were decreased in the THC-treated group. tetrahydrocurcumin 75-78 caspase 9 Sus scrofa 43-52 29976400-0 2018 Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells. tetrahydrocurcumin 0-18 insulin Homo sapiens 86-93 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 sterol regulatory element binding transcription factor 1 Homo sapiens 174-217 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 sterol regulatory element binding transcription factor 1 Homo sapiens 219-227 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 peroxisome proliferator activated receptor gamma Homo sapiens 230-278 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 peroxisome proliferator activated receptor gamma Homo sapiens 280-289 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 fatty acid synthase Homo sapiens 292-311 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 fatty acid synthase Homo sapiens 313-316 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 fatty acid binding protein 4 Homo sapiens 323-351 29976400-4 2018 The results showed that THC treatment significantly decreased lipid accumulation in OA-treated HepG2 cells, possibly, by inhibiting the expression of the lipogenic proteins, sterol regulatory element-binding protein 1 (SREBP-1c), peroxisome proliferator-activated receptor gamma (PPARgamma), fatty acid synthase (FAS), and fatty acid-binding protein 4 (FABP4). tetrahydrocurcumin 24-27 fatty acid binding protein 4 Homo sapiens 353-358 29976400-5 2018 Moreover, THC attenuated OA-induced hepatic lipogenesis in an adenosine monophosphate-activated protein kinase (AMPK)-dependent manner, which was reversed by pretreatment with an AMPK inhibitor. tetrahydrocurcumin 10-13 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 62-110 29976400-5 2018 Moreover, THC attenuated OA-induced hepatic lipogenesis in an adenosine monophosphate-activated protein kinase (AMPK)-dependent manner, which was reversed by pretreatment with an AMPK inhibitor. tetrahydrocurcumin 10-13 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 112-116 29976400-5 2018 Moreover, THC attenuated OA-induced hepatic lipogenesis in an adenosine monophosphate-activated protein kinase (AMPK)-dependent manner, which was reversed by pretreatment with an AMPK inhibitor. tetrahydrocurcumin 10-13 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 179-183 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 insulin receptor substrate 1 Homo sapiens 142-170 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 insulin receptor substrate 1 Homo sapiens 172-177 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 AKT serine/threonine kinase 1 Homo sapiens 212-215 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 forkhead box O1 Homo sapiens 251-274 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 forkhead box O1 Homo sapiens 276-281 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 glycogen synthase kinase 3 beta Homo sapiens 287-318 29976400-7 2018 Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively. tetrahydrocurcumin 94-97 glycogen synthase kinase 3 beta Homo sapiens 320-328 29492979-10 2018 CONCLUSIONS: Tetrahydrocurcumin can synergistically enhance the radiosensitivity of glioma cells by inhibiting the expressions of cyclin D1 and PCNA. tetrahydrocurcumin 13-31 proliferating cell nuclear antigen Mus musculus 144-148 29719770-9 2018 From our study, novel LMTK3 inhibitors tetrahydrocurcumin, curcumin 4,4"-diacetate, and demethoxycurcumin have been proposed with inhibition mechanism. tetrahydrocurcumin 39-57 lemur tyrosine kinase 3 Homo sapiens 22-27 29468071-10 2018 THC therapy restored levels of CuZn SOD and glutathione peroxidase. tetrahydrocurcumin 0-3 superoxide dismutase 1 Rattus norvegicus 31-39 28833102-5 2018 We hypothesized that THC may ameliorates Hcy-induced mitochondria remodeling in mouse brain endothelial cells (bEnd3) cells. tetrahydrocurcumin 21-24 BEN domain containing 3 Mus musculus 111-116 28833102-6 2018 bEnd3 cells were exposed to Hcy treatment in the presence or absence of THC. tetrahydrocurcumin 72-75 BEN domain containing 3 Mus musculus 0-5 28833102-15 2018 Pretreatment of bEnd3 with THC (15 muM) ameliorated Hcy-induced oxidative damage, mitochondrial fission/fusion, and mitophagy. tetrahydrocurcumin 27-30 BEN domain containing 3 Mus musculus 16-21 29436654-0 2018 Tetrahydrocurcumin-induced autophagy via suppression of PI3K/Akt/mTOR in non-small cell lung carcinoma cells. tetrahydrocurcumin 0-18 AKT serine/threonine kinase 1 Homo sapiens 61-64 29436654-0 2018 Tetrahydrocurcumin-induced autophagy via suppression of PI3K/Akt/mTOR in non-small cell lung carcinoma cells. tetrahydrocurcumin 0-18 mechanistic target of rapamycin kinase Homo sapiens 65-69 29436654-7 2018 The RT-qPCR analysis revealed that THC treatment increased Beclin-1 expression level and compared with the control group (P<0.05). tetrahydrocurcumin 35-38 beclin 1 Homo sapiens 59-67 29436654-8 2018 The light chain 3 (LC3)-II/LC3-I ratio was reduced in THC-treated cells when compared with the control group (P<0.05). tetrahydrocurcumin 54-57 microtubule associated protein 1 light chain 3 alpha Homo sapiens 19-22 29436654-8 2018 The light chain 3 (LC3)-II/LC3-I ratio was reduced in THC-treated cells when compared with the control group (P<0.05). tetrahydrocurcumin 54-57 microtubule associated protein 1 light chain 3 alpha Homo sapiens 27-30 29436654-11 2018 A promising method of enhancing the therapeutic efficacy of THC against NSCLC cells may include inducing autophagy via inhibition of the PI3K/Akt/mTOR signaling pathway. tetrahydrocurcumin 60-63 AKT serine/threonine kinase 1 Homo sapiens 142-145 29436654-11 2018 A promising method of enhancing the therapeutic efficacy of THC against NSCLC cells may include inducing autophagy via inhibition of the PI3K/Akt/mTOR signaling pathway. tetrahydrocurcumin 60-63 mechanistic target of rapamycin kinase Homo sapiens 146-150 29023392-0 2017 Disposition, Metabolism and Histone Deacetylase and Acetyltransferase Inhibition Activity of Tetrahydrocurcumin and Other Curcuminoids. tetrahydrocurcumin 93-111 histone deacetylase 9 Homo sapiens 28-47 28766664-7 2017 THC induced the apoptosis of H22 cells obviously by increasing the level of p53 and decreasing the level of murine double minute 2. tetrahydrocurcumin 0-3 transformation related protein 53, pseudogene Mus musculus 76-79 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 0-3 B cell leukemia/lymphoma 2 Mus musculus 37-42 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 0-3 B cell leukemia/lymphoma 2 Mus musculus 89-93 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 0-3 caspase 3 Mus musculus 202-211 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 0-3 caspase 9 Mus musculus 216-225 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 150-153 B cell leukemia/lymphoma 2 Mus musculus 37-42 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 150-153 B cell leukemia/lymphoma 2 Mus musculus 89-93 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 150-153 caspase 3 Mus musculus 202-211 28766664-8 2017 THC also decreased the expression of Bcl-2 significantly and increased the expression of Bcl2-associated X, resulting in the release of cytochrome C. THC significantly activated and induced cleavage of caspase-3 and caspase-9 to induce the apoptosis of H22 cells. tetrahydrocurcumin 150-153 caspase 9 Mus musculus 216-225 29207631-0 2017 Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1alpha and autophagy in human osteosarcoma. tetrahydrocurcumin 0-18 hypoxia inducible factor 1 subunit alpha Homo sapiens 102-112 29207631-8 2017 Mechanistically, our study showed that HIF-1alpha had a pivotal role in the anti-metastatic effect of THC. tetrahydrocurcumin 102-105 hypoxia inducible factor 1 subunit alpha Homo sapiens 39-49 29207631-9 2017 Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways. tetrahydrocurcumin 56-59 hypoxia inducible factor 1 subunit alpha Homo sapiens 13-23 29207631-9 2017 Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways. tetrahydrocurcumin 56-59 AKT serine/threonine kinase 1 Homo sapiens 74-77 29207631-9 2017 Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways. tetrahydrocurcumin 56-59 mechanistic target of rapamycin kinase Homo sapiens 78-82 29207631-9 2017 Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways. tetrahydrocurcumin 56-59 mitogen-activated protein kinase 14 Homo sapiens 87-90 29207631-10 2017 Moreover, THC exhibited a remarkable inhibitory effect on HIF-1alpha expression and angiogenesis under hypoxic conditions. tetrahydrocurcumin 10-13 hypoxia inducible factor 1 subunit alpha Homo sapiens 58-68 29207631-11 2017 Furthermore, THC activated autophagy and induced MET and suppressed angiogenesis in a HIF-1alpha-related manner. tetrahydrocurcumin 13-16 hypoxia inducible factor 1 subunit alpha Homo sapiens 86-96 29207631-12 2017 Taken together, our findings suggest that THC suppresses metastasis and invasion and this may be associated with HIF-1alpha and autophagy, which would potentially provide therapeutic strategies for human osteosarcoma. tetrahydrocurcumin 42-45 hypoxia inducible factor 1 subunit alpha Homo sapiens 113-123 27916377-0 2016 Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism. tetrahydrocurcumin 0-18 AKT serine/threonine kinase 1 Rattus norvegicus 105-108 29669346-10 2017 These results suggest that THC improves neurological outcome after TBI, possibly by activating the Nrf2 signaling pathway. tetrahydrocurcumin 27-30 NFE2 like bZIP transcription factor 2 Rattus norvegicus 99-103 28386319-9 2017 We demonstrated that treatment with THC increased expression of autophagy-associated proteins LC3-II and Beclin-1 at 24 h post-TBI. tetrahydrocurcumin 36-39 beclin 1 Rattus norvegicus 105-113 28386319-12 2017 Treatment with 3-methyladenine (3-MA) mitigated autophagy activation and reversed the inhibitory effect of THC on the translocation of Bax to the mitochondrial membrane. tetrahydrocurcumin 107-110 BCL2 associated X, apoptosis regulator Rattus norvegicus 135-138 27713040-8 2016 An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment. tetrahydrocurcumin 145-148 nitric oxide synthase 3, endothelial cell Mus musculus 21-54 27713040-8 2016 An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment. tetrahydrocurcumin 145-148 nitric oxide synthase 2, inducible Mus musculus 66-79 27713040-8 2016 An imbalance between endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) expression in response to iron overload was normalized by THU, L1 or the combination treatment. tetrahydrocurcumin 145-148 nitric oxide synthase 2, inducible Mus musculus 81-85 27916377-8 2016 RESULTS: Our data indicated that administration of tetrahydrocurcumin alleviated brain edema, attenuated TBI-induced neuron cell death, decreased the degree of apoptosis and improved neurobehavioral function, which were accompanied by enhanced autophagy and phospho-AKT after TBI. tetrahydrocurcumin 51-69 AKT serine/threonine kinase 1 Rattus norvegicus 266-269 27916377-10 2016 CONCLUSIONS: This study indicates that tetrahydrocurcumin protects neurons from TBI-induced apoptotic neuronal death, which may be through modulation autophagy and PI3K/AKT pathways. tetrahydrocurcumin 39-57 AKT serine/threonine kinase 1 Rattus norvegicus 169-172 26881213-9 2016 The CaSki + vehicle group also showed significantly increased COX-2, EGFR, p-ERK1&2, and p-AKT; however they were attenuated by all treatments with THC. tetrahydrocurcumin 152-155 epidermal growth factor receptor Mus musculus 69-73 27748926-0 2016 Suppression of GRASP65 phosphorylation by tetrahydrocurcumin protects against cerebral ischemia/reperfusion injury via ERK signaling. tetrahydrocurcumin 42-60 golgi reassembly stacking protein 1 Mus musculus 15-22 27748926-0 2016 Suppression of GRASP65 phosphorylation by tetrahydrocurcumin protects against cerebral ischemia/reperfusion injury via ERK signaling. tetrahydrocurcumin 42-60 mitogen-activated protein kinase 1 Mus musculus 119-122 29916670-12 2016 VEGF, COX-2, and EGFR were up-regulated in CaSki + vehicle group; however, they were attenuated by THC, celecoxib, and the combination treatments. tetrahydrocurcumin 99-102 vascular endothelial growth factor A Mus musculus 0-4 29916670-13 2016 Conclusion: The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumorangiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. tetrahydrocurcumin 50-53 vascular endothelial growth factor A Mus musculus 148-152 29916670-13 2016 Conclusion: The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumorangiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. tetrahydrocurcumin 50-53 prostaglandin-endoperoxide synthase 2 Mus musculus 154-159 29916670-13 2016 Conclusion: The combinational treatment effect of THC and celecoxib causing inhibition of tumor growth and tumorangiogenesis via down-regulation of VEGF, COX-2 and EGFR expression. tetrahydrocurcumin 50-53 epidermal growth factor receptor Mus musculus 164-168 27748926-7 2016 THC induced a dose-dependent decrease in the phosphorylation of ERK and GRASP65. tetrahydrocurcumin 0-3 mitogen-activated protein kinase 1 Mus musculus 64-67 27748926-7 2016 THC induced a dose-dependent decrease in the phosphorylation of ERK and GRASP65. tetrahydrocurcumin 0-3 golgi reassembly stacking protein 1 Mus musculus 72-79 27748926-8 2016 Thus, THC attenuated I/R injury-induced activation of the ERK signaling pathway and reduced the phosphorylation of GRASP65. tetrahydrocurcumin 6-9 mitogen-activated protein kinase 1 Mus musculus 58-61 27748926-8 2016 Thus, THC attenuated I/R injury-induced activation of the ERK signaling pathway and reduced the phosphorylation of GRASP65. tetrahydrocurcumin 6-9 golgi reassembly stacking protein 1 Mus musculus 115-122 27748926-9 2016 THC exhibited a dose-dependent protective effect against cerebral I/R injury, mediated by suppression of the ERK signaling pathway and a subsequent reduction in GRASP65 phosphorylation. tetrahydrocurcumin 0-3 mitogen-activated protein kinase 1 Mus musculus 109-112 27748926-9 2016 THC exhibited a dose-dependent protective effect against cerebral I/R injury, mediated by suppression of the ERK signaling pathway and a subsequent reduction in GRASP65 phosphorylation. tetrahydrocurcumin 0-3 golgi reassembly stacking protein 1 Mus musculus 161-168 26899573-5 2016 Meanwhile, cytochrome C was released to cytosol and the loss of mitochondria membrane potential (Deltapsim) was observed after THC treatment. tetrahydrocurcumin 127-130 cytochrome c, somatic Homo sapiens 11-23 26881213-9 2016 The CaSki + vehicle group also showed significantly increased COX-2, EGFR, p-ERK1&2, and p-AKT; however they were attenuated by all treatments with THC. tetrahydrocurcumin 152-155 mitogen-activated protein kinase 3 Mus musculus 77-81 25719941-8 2015 Moreover, tetrahydrocurcumin exhibited protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation. tetrahydrocurcumin 10-28 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 129-145 26102010-11 2015 However, drug interactions due to the use of THC as an alternative supplement are of concern, particularly in the combinations that include a drug that is a substrate of Cyp1a1, Cyp2b9, and Cyp3a11. tetrahydrocurcumin 45-48 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 170-176 26102010-11 2015 However, drug interactions due to the use of THC as an alternative supplement are of concern, particularly in the combinations that include a drug that is a substrate of Cyp1a1, Cyp2b9, and Cyp3a11. tetrahydrocurcumin 45-48 cytochrome P450, family 2, subfamily b, polypeptide 9 Mus musculus 178-184 26102010-11 2015 However, drug interactions due to the use of THC as an alternative supplement are of concern, particularly in the combinations that include a drug that is a substrate of Cyp1a1, Cyp2b9, and Cyp3a11. tetrahydrocurcumin 45-48 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 190-197 25502175-3 2015 In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release. tetrahydrocurcumin 26-44 tumor necrosis factor Mus musculus 115-142 25502175-3 2015 In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release. tetrahydrocurcumin 26-44 tumor necrosis factor Mus musculus 144-153 25502175-3 2015 In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release. tetrahydrocurcumin 26-44 interleukin 6 Mus musculus 159-172 25502175-3 2015 In addition, curcumin and tetrahydrocurcumin significantly inhibited the release of prominent cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6); however, hexahydrocurcumin and octahydrocurcumin did not significantly alter cytokine release. tetrahydrocurcumin 26-44 interleukin 6 Mus musculus 174-178 25719941-8 2015 Moreover, tetrahydrocurcumin exhibited protective effects against cisplatin-induced oxidative renal damage in rats by inhibiting cyclooxygenase-2 and caspase-3 activation. tetrahydrocurcumin 10-28 caspase 3 Rattus norvegicus 150-159 25502771-7 2014 Supplementation with THU significantly decreased blood pressure, improved vascular responsiveness, and reversed the structural and mechanical alterations of the aortas, including collagen and elastin deposition. tetrahydrocurcumin 21-24 elastin Mus musculus 192-199 25789317-9 2015 The CaSki + vehicle group also showed significantly increased VEGF, VEGFR-2, and HIF-1alpha expressions, but they were downregulated when mice were treated with THC at all doses. tetrahydrocurcumin 161-164 kinase insert domain protein receptor Mus musculus 68-75 25789317-9 2015 The CaSki + vehicle group also showed significantly increased VEGF, VEGFR-2, and HIF-1alpha expressions, but they were downregulated when mice were treated with THC at all doses. tetrahydrocurcumin 161-164 hypoxia inducible factor 1, alpha subunit Mus musculus 81-91 25547723-6 2014 Other studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. tetrahydrocurcumin 37-40 glutathione S-transferase kappa 1 Homo sapiens 98-123 25547723-6 2014 Other studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. tetrahydrocurcumin 37-40 crystallin zeta Homo sapiens 125-149 24725345-2 2014 In the present study, we hypothesised that the different cellular uptake and/or metabolism of CUR and THC might be a possible explanation for the previously observed differences in their effects on lipid accumulation in THP-1 monocytes/macrophages. tetrahydrocurcumin 102-105 GLI family zinc finger 2 Homo sapiens 220-225 24725345-6 2014 From these results, it is possible to deduce that CUR and THC are taken up and metabolised differently in THP-1 cells, which determine their biological activity. tetrahydrocurcumin 58-61 GLI family zinc finger 2 Homo sapiens 106-111 23325575-8 2013 In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2. tetrahydrocurcumin 13-16 forkhead box, sub-group O Drosophila melanogaster 107-111 24593988-0 2014 Tetrahydrocurcumin induces G2/M cell cycle arrest and apoptosis involving p38 MAPK activation in human breast cancer cells. tetrahydrocurcumin 0-18 mitogen-activated protein kinase 14 Homo sapiens 74-77 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 43-46 BCL2 associated X, apoptosis regulator Homo sapiens 192-195 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 43-46 BCL2 apoptosis regulator Homo sapiens 211-216 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 43-46 caspase 3 Homo sapiens 234-243 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 43-46 H3 histone pseudogene 16 Homo sapiens 266-269 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 43-46 mitogen-activated protein kinase 14 Homo sapiens 296-299 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 mitogen-activated protein kinase 14 Homo sapiens 51-54 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 BCL2 associated X, apoptosis regulator Homo sapiens 192-195 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 BCL2 apoptosis regulator Homo sapiens 211-216 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 caspase 3 Homo sapiens 234-243 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 H3 histone pseudogene 16 Homo sapiens 266-269 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 mitogen-activated protein kinase 14 Homo sapiens 296-299 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 mitogen-activated protein kinase 14 Homo sapiens 51-54 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 BCL2 associated X, apoptosis regulator Homo sapiens 192-195 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 BCL2 apoptosis regulator Homo sapiens 211-216 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 caspase 3 Homo sapiens 234-243 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 H3 histone pseudogene 16 Homo sapiens 266-269 24593988-8 2014 Moreover, co-treatment of MCF-7 cells with THC and p38 MAPK inhibitor, SB203580, effectively reversed the dissipation in mitochondrial membrane potential (Deltapsim), and blocked THC-mediated Bax up-regulation, Bcl-2 down-regulation, caspase-3 activation as well as p21 up-regulation, suggesting p38 MAPK might mediate THC-induced apoptosis and G2/M arrest. tetrahydrocurcumin 179-182 mitogen-activated protein kinase 14 Homo sapiens 296-299 23325575-8 2013 In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2. tetrahydrocurcumin 13-16 Sirtuin 1 Drosophila melanogaster 116-120 22212488-17 2012 THC also decreased oxidative damage and ameliorated the homocysteinylation of cyto-c in-part by MMP-9 activation which leads to autophagy in I/R groups as compared to sham-operated groups. tetrahydrocurcumin 0-3 matrix metallopeptidase 9 Mus musculus 96-101 23058916-7 2012 Tetrahydrocurcumin, a curcumin metabolite, showed a less potent inhibitory effect on I(CRAC), and this effect was abolished in C195S Orai1. tetrahydrocurcumin 0-18 ORAI calcium release-activated calcium modulator 1 Homo sapiens 133-138 21928294-0 2011 Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. tetrahydrocurcumin 0-18 AKT serine/threonine kinase 1 Homo sapiens 122-125 21887819-5 2011 At the molecular level, results from Western blot analysis and immunohistochemistry staining showed that dietary CUR and THC exhibited anti-inflammatory activity by decreasing the levels of inducible NOS and COX-2 through downregulation of ERK1/2 activation. tetrahydrocurcumin 121-124 cytochrome c oxidase II, mitochondrial Mus musculus 208-213 21887819-5 2011 At the molecular level, results from Western blot analysis and immunohistochemistry staining showed that dietary CUR and THC exhibited anti-inflammatory activity by decreasing the levels of inducible NOS and COX-2 through downregulation of ERK1/2 activation. tetrahydrocurcumin 121-124 mitogen-activated protein kinase 3 Mus musculus 240-246 21887819-6 2011 In addition, both dietary CUR and THC significantly decreased AOM-induced Wnt-1 and beta-catenin protein expression, as well as the phosphorylation of GSK-3beta in colonic tissue. tetrahydrocurcumin 34-37 wingless-type MMTV integration site family, member 1 Mus musculus 74-79 21887819-6 2011 In addition, both dietary CUR and THC significantly decreased AOM-induced Wnt-1 and beta-catenin protein expression, as well as the phosphorylation of GSK-3beta in colonic tissue. tetrahydrocurcumin 34-37 catenin (cadherin associated protein), beta 1 Mus musculus 84-96 21887819-6 2011 In addition, both dietary CUR and THC significantly decreased AOM-induced Wnt-1 and beta-catenin protein expression, as well as the phosphorylation of GSK-3beta in colonic tissue. tetrahydrocurcumin 34-37 glycogen synthase kinase 3 beta Mus musculus 151-160 21887819-7 2011 Moreover, dietary feeding with CUR and THC markedly reduced the protein level of connexin-43, an important molecule of gap junctions, indicating that both CUR and THC might interfer with the intercellular communication of crypt cells. tetrahydrocurcumin 39-42 gap junction protein, alpha 1 Mus musculus 81-92 21887819-7 2011 Moreover, dietary feeding with CUR and THC markedly reduced the protein level of connexin-43, an important molecule of gap junctions, indicating that both CUR and THC might interfer with the intercellular communication of crypt cells. tetrahydrocurcumin 163-166 gap junction protein, alpha 1 Mus musculus 81-92 22156377-0 2011 Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. tetrahydrocurcumin 0-18 forkhead box, sub-group O Drosophila melanogaster 98-102 22156377-4 2011 Here, we show that tetrahydrocurcumin (THC), a curcumin metabolite, regulates the oxidative stress response and aging via FOXO. tetrahydrocurcumin 19-37 forkhead box, sub-group O Drosophila melanogaster 122-126 22156377-4 2011 Here, we show that tetrahydrocurcumin (THC), a curcumin metabolite, regulates the oxidative stress response and aging via FOXO. tetrahydrocurcumin 39-42 forkhead box, sub-group O Drosophila melanogaster 122-126 22156377-5 2011 In NIH3T3 cells, THC induced nuclear accumulation of FOXO4, a member of the FOXO family of transcription factors, by inhibiting phosphorylation of protein kinase B (PKB)/Akt. tetrahydrocurcumin 17-20 forkhead box O4 Mus musculus 53-58 22156377-5 2011 In NIH3T3 cells, THC induced nuclear accumulation of FOXO4, a member of the FOXO family of transcription factors, by inhibiting phosphorylation of protein kinase B (PKB)/Akt. tetrahydrocurcumin 17-20 forkhead box, sub-group O Drosophila melanogaster 53-57 22156377-5 2011 In NIH3T3 cells, THC induced nuclear accumulation of FOXO4, a member of the FOXO family of transcription factors, by inhibiting phosphorylation of protein kinase B (PKB)/Akt. tetrahydrocurcumin 17-20 thymoma viral proto-oncogene 1 Mus musculus 165-168 22156377-5 2011 In NIH3T3 cells, THC induced nuclear accumulation of FOXO4, a member of the FOXO family of transcription factors, by inhibiting phosphorylation of protein kinase B (PKB)/Akt. tetrahydrocurcumin 17-20 thymoma viral proto-oncogene 1 Mus musculus 170-173 22156377-6 2011 In Drosophila melanogaster, THC attenuated the oxidative stress response, an effect that was blocked in a foxo mutant background. tetrahydrocurcumin 28-31 forkhead box, sub-group O Drosophila melanogaster 106-110 22156377-8 2011 Based on these results, THC may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2. tetrahydrocurcumin 24-27 forkhead box, sub-group O Drosophila melanogaster 128-132 22156377-8 2011 Based on these results, THC may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2. tetrahydrocurcumin 24-27 Sirtuin 1 Drosophila melanogaster 137-141 21928294-6 2011 At the molecular levels, the results from Western blot analysis showed that THC significantly down-regulated phosphatidylinositol 3-kinase/protein kinase B and mitogen-activated protein kinase signalings including decreasing the phosphorylation of mammalian target of rapamycin, glycogen synthase kinase 3beta and p70 ribosomal protein S6 kinase. tetrahydrocurcumin 76-79 protein tyrosine kinase 2 beta Homo sapiens 139-155 21928294-6 2011 At the molecular levels, the results from Western blot analysis showed that THC significantly down-regulated phosphatidylinositol 3-kinase/protein kinase B and mitogen-activated protein kinase signalings including decreasing the phosphorylation of mammalian target of rapamycin, glycogen synthase kinase 3beta and p70 ribosomal protein S6 kinase. tetrahydrocurcumin 76-79 mechanistic target of rapamycin kinase Homo sapiens 248-277 21928294-6 2011 At the molecular levels, the results from Western blot analysis showed that THC significantly down-regulated phosphatidylinositol 3-kinase/protein kinase B and mitogen-activated protein kinase signalings including decreasing the phosphorylation of mammalian target of rapamycin, glycogen synthase kinase 3beta and p70 ribosomal protein S6 kinase. tetrahydrocurcumin 76-79 glycogen synthase kinase 3 beta Homo sapiens 279-309 21928294-0 2011 Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells. tetrahydrocurcumin 0-18 mechanistic target of rapamycin kinase Homo sapiens 126-130 20456495-5 2010 Primary human keratinocytes treated with curcumin or THC demonstrated decreased activation of p44/42 MAP kinases but increased levels of activated p38 MAP kinases. tetrahydrocurcumin 53-56 interferon induced protein 44 Homo sapiens 94-97 20934924-1 2010 Curcumin and tetrahydrocurcumin (THC) have been found as potent DNMT1 inhibitors, but they suffer from low oral bioavailability and rapid metabolism in vivo. tetrahydrocurcumin 13-31 DNA methyltransferase (cytosine-5) 1 Mus musculus 64-69 20934924-1 2010 Curcumin and tetrahydrocurcumin (THC) have been found as potent DNMT1 inhibitors, but they suffer from low oral bioavailability and rapid metabolism in vivo. tetrahydrocurcumin 33-36 DNA methyltransferase (cytosine-5) 1 Mus musculus 64-69 20456495-5 2010 Primary human keratinocytes treated with curcumin or THC demonstrated decreased activation of p44/42 MAP kinases but increased levels of activated p38 MAP kinases. tetrahydrocurcumin 53-56 mitogen-activated protein kinase 14 Homo sapiens 147-150 20456495-9 2010 Both curcuminoids induced G2/M block and inhibited keratinocyte growth, and THC increased cellular levels of p21, a known p53 transcriptional target. tetrahydrocurcumin 76-79 H3 histone pseudogene 16 Homo sapiens 109-112 20456495-9 2010 Both curcuminoids induced G2/M block and inhibited keratinocyte growth, and THC increased cellular levels of p21, a known p53 transcriptional target. tetrahydrocurcumin 76-79 tumor protein p53 Homo sapiens 122-125 16960658-4 2007 In this study, the effect of tetrahydrocurcumin (THC) on three ABC drug transporter proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) is able to modulate MDR in cancer cells. tetrahydrocurcumin 49-52 ATP binding cassette subfamily B member 1 Homo sapiens 94-108 18565284-7 2008 Zymography assay was used to analyze the effect of THC on matrix metalloproteinase (MMP)-2, MMP-9, and urokinase plasminogen activator (uPA) secretion from HT1080 cells. tetrahydrocurcumin 51-54 matrix metallopeptidase 2 Homo sapiens 58-90 18565284-11 2008 Analysis by zymography demonstrated that treatment with THC reduced the levels of MMP-2, MMP-9, and uPA. tetrahydrocurcumin 56-59 matrix metallopeptidase 2 Homo sapiens 82-87 18565284-11 2008 Analysis by zymography demonstrated that treatment with THC reduced the levels of MMP-2, MMP-9, and uPA. tetrahydrocurcumin 56-59 matrix metallopeptidase 9 Homo sapiens 89-94 18565284-11 2008 Analysis by zymography demonstrated that treatment with THC reduced the levels of MMP-2, MMP-9, and uPA. tetrahydrocurcumin 56-59 plasminogen activator, urokinase Homo sapiens 100-103 18565284-12 2008 THC also inhibited the levels of MT1-MMP and TIMP-2 proteins detected by Western blot analysis. tetrahydrocurcumin 0-3 matrix metallopeptidase 14 Homo sapiens 33-40 18565284-12 2008 THC also inhibited the levels of MT1-MMP and TIMP-2 proteins detected by Western blot analysis. tetrahydrocurcumin 0-3 TIMP metallopeptidase inhibitor 2 Homo sapiens 45-51 18408903-0 2008 Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson"s disease induced by MPTP neurodegeneration in mice. tetrahydrocurcumin 92-110 monoamine oxidase B Mus musculus 14-33 18408903-6 2008 The results showed that curcumin and tetrahydrocurcumin reversed the MPTP induced depletion of DA and DOPAC which may in part be due to inhibition of MAO-B activity. tetrahydrocurcumin 37-55 monoamine oxidase B Mus musculus 150-155 17651069-4 2007 In addition, THC caused significant increases in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and reduced glutathione in the brains of diabetic rats with significant decrease in the lipid peroxidative markers thiobarbituric acid-reactive substances and hydroperoxides in brain, suggesting efficacy for protection against lipid peroxidation-induced membrane damage. tetrahydrocurcumin 13-16 catalase Rattus norvegicus 89-97 17651069-4 2007 In addition, THC caused significant increases in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, and reduced glutathione in the brains of diabetic rats with significant decrease in the lipid peroxidative markers thiobarbituric acid-reactive substances and hydroperoxides in brain, suggesting efficacy for protection against lipid peroxidation-induced membrane damage. tetrahydrocurcumin 13-16 hematopoietic prostaglandin D synthase Rattus norvegicus 123-148 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. tetrahydrocurcumin 165-183 ATP binding cassette subfamily B member 1 Homo sapiens 55-69 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. tetrahydrocurcumin 165-183 ATP binding cassette subfamily B member 1 Homo sapiens 71-76 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. tetrahydrocurcumin 165-183 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 112-117 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. tetrahydrocurcumin 165-183 ATP binding cassette subfamily B member 1 Homo sapiens 123-153 16960658-0 2007 Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. tetrahydrocurcumin 165-183 ATP binding cassette subfamily C member 1 Homo sapiens 155-160 18565284-0 2008 Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA. tetrahydrocurcumin 0-18 matrix metallopeptidase 2 Homo sapiens 85-89 18565284-0 2008 Tetrahydrocurcumin inhibits HT1080 cell migration and invasion via downregulation of MMPs and uPA. tetrahydrocurcumin 0-18 plasminogen activator, urokinase Homo sapiens 94-97 18417733-4 2008 In both the acute (LPS) and chronic inflammation (Tg2576), TC and curcumin similarly reduced interleukin-1beta. tetrahydrocurcumin 59-61 interleukin 1 beta Mus musculus 93-110 18417733-6 2008 TC had no impact on plaques or insoluble Abeta, but both reduced Tris-buffered saline-soluble Abeta and phospho-c-Jun NH(2)-terminal kinase (JNK). tetrahydrocurcumin 0-2 amyloid beta (A4) precursor protein Mus musculus 94-99 18417733-6 2008 TC had no impact on plaques or insoluble Abeta, but both reduced Tris-buffered saline-soluble Abeta and phospho-c-Jun NH(2)-terminal kinase (JNK). tetrahydrocurcumin 0-2 mitogen-activated protein kinase 8 Mus musculus 104-139 18417733-6 2008 TC had no impact on plaques or insoluble Abeta, but both reduced Tris-buffered saline-soluble Abeta and phospho-c-Jun NH(2)-terminal kinase (JNK). tetrahydrocurcumin 0-2 mitogen-activated protein kinase 8 Mus musculus 141-144 18417733-10 2008 Nevertheless, TC did reduce neuroinflammation and soluble Abeta, effects that may be attributable to limiting JNK-mediated transcription. tetrahydrocurcumin 14-16 amyloid beta (A4) precursor protein Mus musculus 58-63 18417733-10 2008 Nevertheless, TC did reduce neuroinflammation and soluble Abeta, effects that may be attributable to limiting JNK-mediated transcription. tetrahydrocurcumin 14-16 mitogen-activated protein kinase 8 Mus musculus 110-113 18376071-0 2008 Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. tetrahydrocurcumin 10-28 insulin receptor Rattus norvegicus 32-48 17603281-2 2007 In the present study, we investigated whether the phytochemical curcumin and its metabolite tetrahydrocurcumin could induce HO-1 expression and growth inhibition in rat VSMCs and, if so, whether their antiproliferative effect could be mediated via HO-1 expression. tetrahydrocurcumin 92-110 heme oxygenase 1 Rattus norvegicus 124-128 16960658-15 2007 Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells. tetrahydrocurcumin 99-102 ATP binding cassette subfamily C member 1 Homo sapiens 156-160 16960658-16 2007 The MDR reversing properties of THC on P-gp, MRP1, and MXR were determined by MTT assay. tetrahydrocurcumin 32-35 phosphoglycolate phosphatase Homo sapiens 39-43 16960658-16 2007 The MDR reversing properties of THC on P-gp, MRP1, and MXR were determined by MTT assay. tetrahydrocurcumin 32-35 ATP binding cassette subfamily C member 1 Homo sapiens 45-49 16960658-16 2007 The MDR reversing properties of THC on P-gp, MRP1, and MXR were determined by MTT assay. tetrahydrocurcumin 32-35 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 55-58 16960658-17 2007 THC significantly increased the sensitivity of vinblastine, mitoxantrone and etoposide in drug resistance KB-V-1, MCF7AdrVp3000 and MRP1-HEK 293 cells, respectively. tetrahydrocurcumin 0-3 ATP binding cassette subfamily C member 1 Homo sapiens 132-136 16960658-19 2007 Taken together, this study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo. tetrahydrocurcumin 47-50 phosphoglycolate phosphatase Homo sapiens 83-87 16960658-19 2007 Taken together, this study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo. tetrahydrocurcumin 47-50 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 89-92 16960658-19 2007 Taken together, this study clearly showed that THC inhibits the efflux function of P-gp, MXR and MRP1 and it is able to extend the MDR reversing activity of curcuminoids in vivo. tetrahydrocurcumin 47-50 ATP binding cassette subfamily C member 1 Homo sapiens 97-101 16960658-4 2007 In this study, the effect of tetrahydrocurcumin (THC) on three ABC drug transporter proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) is able to modulate MDR in cancer cells. tetrahydrocurcumin 29-47 ATP binding cassette subfamily B member 1 Homo sapiens 94-108 16960658-6 2007 We report here for the first time that THC is able to inhibit the function of P-gp, MXR and MRP1. tetrahydrocurcumin 39-42 phosphoglycolate phosphatase Homo sapiens 78-82 16960658-6 2007 We report here for the first time that THC is able to inhibit the function of P-gp, MXR and MRP1. tetrahydrocurcumin 39-42 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 84-87 16960658-6 2007 We report here for the first time that THC is able to inhibit the function of P-gp, MXR and MRP1. tetrahydrocurcumin 39-42 ATP binding cassette subfamily C member 1 Homo sapiens 92-96 16960658-7 2007 The results of flow cytometry assay indicated that THC is able to inhibit the function of P-gp and thereby significantly increase the accumulation of rhodamine and calcein AM in KB-V-1 cells. tetrahydrocurcumin 51-54 phosphoglycolate phosphatase Homo sapiens 90-94 16960658-11 2007 The interaction of THC with the P-gp molecule was clearly indicated by ATPase assay and photoaffinity labeling of P-gp with transport substrate. tetrahydrocurcumin 19-22 phosphoglycolate phosphatase Homo sapiens 32-36 16960658-11 2007 The interaction of THC with the P-gp molecule was clearly indicated by ATPase assay and photoaffinity labeling of P-gp with transport substrate. tetrahydrocurcumin 19-22 dynein axonemal heavy chain 8 Homo sapiens 71-77 16960658-11 2007 The interaction of THC with the P-gp molecule was clearly indicated by ATPase assay and photoaffinity labeling of P-gp with transport substrate. tetrahydrocurcumin 19-22 phosphoglycolate phosphatase Homo sapiens 114-118 16960658-12 2007 THC stimulated P-gp ATPase activity and inhibited the incorporation of [(125)I]-iodoarylazidoprazosin (IAAP) into P-gp in a concentration-dependent manner. tetrahydrocurcumin 0-3 phosphoglycolate phosphatase Homo sapiens 15-19 16960658-12 2007 THC stimulated P-gp ATPase activity and inhibited the incorporation of [(125)I]-iodoarylazidoprazosin (IAAP) into P-gp in a concentration-dependent manner. tetrahydrocurcumin 0-3 dynein axonemal heavy chain 8 Homo sapiens 20-26 16960658-12 2007 THC stimulated P-gp ATPase activity and inhibited the incorporation of [(125)I]-iodoarylazidoprazosin (IAAP) into P-gp in a concentration-dependent manner. tetrahydrocurcumin 0-3 phosphoglycolate phosphatase Homo sapiens 114-118 16960658-13 2007 The binding of [(125)I]-IAAP to MXR was also inhibited by THC suggesting that THC interacted with drug binding site of the transporter. tetrahydrocurcumin 58-61 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 32-35 16960658-13 2007 The binding of [(125)I]-IAAP to MXR was also inhibited by THC suggesting that THC interacted with drug binding site of the transporter. tetrahydrocurcumin 78-81 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 32-35 16960658-14 2007 THC dose dependently inhibited the efflux of mitoxantrone and pheophorbide A from MXR expressing cells (MCF7AdrVp3000 and MCF7FL1000). tetrahydrocurcumin 0-3 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 82-85 16960658-15 2007 Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells. tetrahydrocurcumin 99-102 ATP binding cassette subfamily C member 1 Homo sapiens 15-19 15073046-10 2004 Curcumin and THC potently inhibited the activity of human recombinant 5-LOX, showing estimated IC(50) values of 0.7 and 3 micro M, respectively. tetrahydrocurcumin 13-16 arachidonate 5-lipoxygenase Homo sapiens 70-75 16806281-4 2006 In addition, THC caused significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in liver and kidney of diabetic rats with significant decrease in thiobarbituric acid reactive substances (TBARS) and hydroperoxides formation in liver and kidney, suggesting its role in protection against lipid peroxidation induced membrane damage. tetrahydrocurcumin 13-16 catalase Rattus norvegicus 88-96 16806281-4 2006 In addition, THC caused significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in liver and kidney of diabetic rats with significant decrease in thiobarbituric acid reactive substances (TBARS) and hydroperoxides formation in liver and kidney, suggesting its role in protection against lipid peroxidation induced membrane damage. tetrahydrocurcumin 13-16 hematopoietic prostaglandin D synthase Rattus norvegicus 122-147 11077049-2 2000 In this study, we investigated the inhibitory effects of curcumin and its metabolites, tetrahydrocurcumin, hexahydrocurcumin, and octahydrocurcumin, on the induction of NO synthase (NOS) in RAW 264.7 cells activated with lipopolysaccharide (LPS). tetrahydrocurcumin 87-105 nitric oxide synthase 1, neuronal Mus musculus 169-180 14511674-6 2003 Co-treatment with isoflavones, curcumin and tetrahydrocurcumin, increased [3H]EGCG accumulation significantly in MDCKII/MRP1 and HT-29 cells. tetrahydrocurcumin 44-62 ATP binding cassette subfamily C member 1 Canis lupus familiaris 120-124 10101144-7 1999 Treatment of the plasma with beta-glucuronidase resulted in a decrease in the concentrations of these two putative conjugates and the concomitant appearance of tetrahydrocurcumin (THC) and curcumin, respectively. tetrahydrocurcumin 160-178 glucuronidase, beta Mus musculus 29-47 10101144-7 1999 Treatment of the plasma with beta-glucuronidase resulted in a decrease in the concentrations of these two putative conjugates and the concomitant appearance of tetrahydrocurcumin (THC) and curcumin, respectively. tetrahydrocurcumin 180-183 glucuronidase, beta Mus musculus 29-47