PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33259114-0	2021	Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway.	gracillin	0-9	signal transducer and activator of transcription 3	Homo sapiens	81-86
33259114-10	2021	In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3.	gracillin	13-22	interleukin 6	Homo sapiens	32-35
33259114-10	2021	In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3.	gracillin	13-22	signal transducer and activator of transcription 3	Homo sapiens	71-76
25980181-4	2015	Flow cytometry was used to analyze the cell cycle distribution whereas Annexin V-FITC/PI flow cytometry analysis was carried out to confirm apoptosis induced by gracillin, Our results demonstrated that gracillin could induce cell cycle arrest of G1 and apoptosis in HL60 cells.	gracillin	202-211	annexin A5	Homo sapiens	71-80
31941605-0	2020	Gracillin inhibits apoptosis and inflammation induced by lipopolysaccharide (LPS) to alleviate cardiac injury in mice via improving miR-29a.	gracillin	0-9	microRNA 29a	Mus musculus	132-139
31941605-4	2020	First, we found that GRA treatments markedly up-regulated the expression of miR-29a in cardiomyocytes.	gracillin	21-24	microRNA 29a	Mus musculus	76-83
31941605-9	2020	In addition, GRA markedly attenuated apoptosis in hearts of LPS-challenged mice by decreasing the expression of cleaved Caspase-3.	gracillin	13-16	caspase 3	Mus musculus	120-129
31941605-10	2020	LPS-triggered inflammatory response in cardiac tissues was also suppressed by GRA through blocking nuclear factor kappaB (NF-kappaB) signaling pathway.	gracillin	78-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	122-131
31941605-11	2020	We also found that miR-29a expression was highly reduced in hearts of LPS-treated mice but was rescued by GRA pretreatment.	gracillin	106-109	microRNA 29a	Mus musculus	19-26
31941605-13	2020	Of note, the protective effects of GRA on LPS-injured cardiac tissues were significantly abrogated by miR-29a suppression.	gracillin	35-38	microRNA 29a	Mus musculus	102-109
31941605-14	2020	In conclusion, our findings demonstrated that GRA exerted an effective role against LPS-induced acute cardiac injury through impeding apoptosis and inflammation regulated by miR-29a.	gracillin	46-49	microRNA 29a	Mus musculus	174-181
32276500-6	2020	A docking analysis and enzyme assay suggested phosphoglycerate kinase 1 (PGK1) is a potential target for the antiglycolytic effect of gracillin.	gracillin	134-143	phosphoglycerate kinase 1	Homo sapiens	46-71
32276500-6	2020	A docking analysis and enzyme assay suggested phosphoglycerate kinase 1 (PGK1) is a potential target for the antiglycolytic effect of gracillin.	gracillin	134-143	phosphoglycerate kinase 1	Homo sapiens	73-77
31649278-4	2019	Gracillin displayed broad-spectrum inhibitory effects on the viability of a large panel of human cancer cell lines, including those carrying acquired resistance to chemotherapy or EGFR-targeting drugs, by inducing apoptosis.	gracillin	0-9	epidermal growth factor receptor	Homo sapiens	180-184
31649278-6	2019	Mechanistically, gracillin disrupts complex II (CII) function by abrogating succinate dehydrogenase (SDH) activity without affecting the succinate:ubiquinone reductase.	gracillin	17-26	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	76-99
31649278-6	2019	Mechanistically, gracillin disrupts complex II (CII) function by abrogating succinate dehydrogenase (SDH) activity without affecting the succinate:ubiquinone reductase.	gracillin	17-26	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	101-104
31649278-7	2019	The gracillin-induced cell death was potentiated by 3-nitropropionic acid (3-NPA) or thenoyltrifluoroacetone (TTFA), which inhibit CII by binding to the active site of SDHA or to the ubiquinone-binding site, respectively.	gracillin	4-13	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	168-172
30200442-5	2018	In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice.	gracillin	13-22	interleukin 4	Rattus norvegicus	53-57
25980181-5	2015	Furthermore, based on the biochemical methods, induction of oxidative stress by gracillin was indicated by increased the content of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity.	gracillin	80-89	superoxide dismutase 1	Homo sapiens	169-189
25980181-5	2015	Furthermore, based on the biochemical methods, induction of oxidative stress by gracillin was indicated by increased the content of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity.	gracillin	80-89	superoxide dismutase 1	Homo sapiens	191-194
35392243-0	2022	Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.	gracillin	0-9	mechanistic target of rapamycin kinase	Mus musculus	93-97
34630074-0	2021	Beneficial Effects of Gracillin From Rhizoma Paridis Against Gastric Carcinoma via the Potential TIPE2-Mediated Induction of Endogenous Apoptosis and Inhibition of Migration in BGC823 Cells.	gracillin	22-31	TNF alpha induced protein 8 like 2	Homo sapiens	97-102
34630074-5	2021	Interestingly, gracillin, a component from the ethyl acetate extraction of Rhizoma Paridis, was identified to induce the expression of TIPE2 and inhibit the cell proliferation in gastric cancer BGC-823 cells.	gracillin	15-24	TNF alpha induced protein 8 like 2	Homo sapiens	135-140
34630074-7	2021	Meanwhile, the role of TIPE2 in the anti-tumor effect of gracillin was elucidated via the use of siTIPE2 RNA.	gracillin	57-66	TNF alpha induced protein 8 like 2	Homo sapiens	23-28
34630074-8	2021	It was determined that gracillin could fight against gastric cancer cells by inhibiting the cell proliferation participated by the PI3K/AKT pathway and cell cycle arrest, suppressing the EMT pathway-regulating cell migration, and inducing bcl2-associated mitochondrial apoptosis.	gracillin	23-32	AKT serine/threonine kinase 1	Homo sapiens	136-139
34630074-8	2021	It was determined that gracillin could fight against gastric cancer cells by inhibiting the cell proliferation participated by the PI3K/AKT pathway and cell cycle arrest, suppressing the EMT pathway-regulating cell migration, and inducing bcl2-associated mitochondrial apoptosis.	gracillin	23-32	BCL2 apoptosis regulator	Homo sapiens	239-243
35392243-8	2022	The further mechanism study found that the mTOR signaling pathway was significantly inhibited by gracillin.	gracillin	97-106	mechanistic target of rapamycin kinase	Mus musculus	43-47
35392243-10	2022	Meanwhile, LC3-II transformation was found to be significantly reduced after WIPI1 was silenced in A549 cells but increased after gracillin treatment.	gracillin	130-139	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	11-14
35392243-14	2022	The mechanism maybe that gracillin inhibited the mTOR signaling pathway.	gracillin	25-34	mechanistic target of rapamycin kinase	Mus musculus	49-53