PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31941605-0 2020 Gracillin inhibits apoptosis and inflammation induced by lipopolysaccharide (LPS) to alleviate cardiac injury in mice via improving miR-29a. gracillin 0-9 microRNA 29a Mus musculus 132-139 33259114-0 2021 Gracillin shows potent efficacy against colorectal cancer through inhibiting the STAT3 pathway. gracillin 0-9 signal transducer and activator of transcription 3 Homo sapiens 81-86 33259114-10 2021 In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3. gracillin 13-22 interleukin 6 Homo sapiens 32-35 33259114-10 2021 In addition, gracillin inhibits IL6-induced nuclear translocation of P-STAT3. gracillin 13-22 signal transducer and activator of transcription 3 Homo sapiens 71-76 32276500-6 2020 A docking analysis and enzyme assay suggested phosphoglycerate kinase 1 (PGK1) is a potential target for the antiglycolytic effect of gracillin. gracillin 134-143 phosphoglycerate kinase 1 Homo sapiens 46-71 32276500-6 2020 A docking analysis and enzyme assay suggested phosphoglycerate kinase 1 (PGK1) is a potential target for the antiglycolytic effect of gracillin. gracillin 134-143 phosphoglycerate kinase 1 Homo sapiens 73-77 31941605-4 2020 First, we found that GRA treatments markedly up-regulated the expression of miR-29a in cardiomyocytes. gracillin 21-24 microRNA 29a Mus musculus 76-83 31941605-9 2020 In addition, GRA markedly attenuated apoptosis in hearts of LPS-challenged mice by decreasing the expression of cleaved Caspase-3. gracillin 13-16 caspase 3 Mus musculus 120-129 31941605-10 2020 LPS-triggered inflammatory response in cardiac tissues was also suppressed by GRA through blocking nuclear factor kappaB (NF-kappaB) signaling pathway. gracillin 78-81 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 122-131 31941605-11 2020 We also found that miR-29a expression was highly reduced in hearts of LPS-treated mice but was rescued by GRA pretreatment. gracillin 106-109 microRNA 29a Mus musculus 19-26 31941605-13 2020 Of note, the protective effects of GRA on LPS-injured cardiac tissues were significantly abrogated by miR-29a suppression. gracillin 35-38 microRNA 29a Mus musculus 102-109 31941605-14 2020 In conclusion, our findings demonstrated that GRA exerted an effective role against LPS-induced acute cardiac injury through impeding apoptosis and inflammation regulated by miR-29a. gracillin 46-49 microRNA 29a Mus musculus 174-181 31649278-4 2019 Gracillin displayed broad-spectrum inhibitory effects on the viability of a large panel of human cancer cell lines, including those carrying acquired resistance to chemotherapy or EGFR-targeting drugs, by inducing apoptosis. gracillin 0-9 epidermal growth factor receptor Homo sapiens 180-184 31649278-6 2019 Mechanistically, gracillin disrupts complex II (CII) function by abrogating succinate dehydrogenase (SDH) activity without affecting the succinate:ubiquinone reductase. gracillin 17-26 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 76-99 31649278-6 2019 Mechanistically, gracillin disrupts complex II (CII) function by abrogating succinate dehydrogenase (SDH) activity without affecting the succinate:ubiquinone reductase. gracillin 17-26 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 101-104 31649278-7 2019 The gracillin-induced cell death was potentiated by 3-nitropropionic acid (3-NPA) or thenoyltrifluoroacetone (TTFA), which inhibit CII by binding to the active site of SDHA or to the ubiquinone-binding site, respectively. gracillin 4-13 succinate dehydrogenase complex flavoprotein subunit A Homo sapiens 168-172 25980181-4 2015 Flow cytometry was used to analyze the cell cycle distribution whereas Annexin V-FITC/PI flow cytometry analysis was carried out to confirm apoptosis induced by gracillin, Our results demonstrated that gracillin could induce cell cycle arrest of G1 and apoptosis in HL60 cells. gracillin 202-211 annexin A5 Homo sapiens 71-80 30200442-5 2018 In addition, gracillin strongly inhibited PI-induced IL-4 expression in RBL-2H3 cells and in the skins of AD mice. gracillin 13-22 interleukin 4 Rattus norvegicus 53-57 25980181-5 2015 Furthermore, based on the biochemical methods, induction of oxidative stress by gracillin was indicated by increased the content of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity. gracillin 80-89 superoxide dismutase 1 Homo sapiens 169-189 25980181-5 2015 Furthermore, based on the biochemical methods, induction of oxidative stress by gracillin was indicated by increased the content of malondialdehyde (MDA), and decreased superoxide dismutase (SOD) activity. gracillin 80-89 superoxide dismutase 1 Homo sapiens 191-194 34630074-0 2021 Beneficial Effects of Gracillin From Rhizoma Paridis Against Gastric Carcinoma via the Potential TIPE2-Mediated Induction of Endogenous Apoptosis and Inhibition of Migration in BGC823 Cells. gracillin 22-31 TNF alpha induced protein 8 like 2 Homo sapiens 97-102 34630074-5 2021 Interestingly, gracillin, a component from the ethyl acetate extraction of Rhizoma Paridis, was identified to induce the expression of TIPE2 and inhibit the cell proliferation in gastric cancer BGC-823 cells. gracillin 15-24 TNF alpha induced protein 8 like 2 Homo sapiens 135-140 34630074-7 2021 Meanwhile, the role of TIPE2 in the anti-tumor effect of gracillin was elucidated via the use of siTIPE2 RNA. gracillin 57-66 TNF alpha induced protein 8 like 2 Homo sapiens 23-28 34630074-8 2021 It was determined that gracillin could fight against gastric cancer cells by inhibiting the cell proliferation participated by the PI3K/AKT pathway and cell cycle arrest, suppressing the EMT pathway-regulating cell migration, and inducing bcl2-associated mitochondrial apoptosis. gracillin 23-32 AKT serine/threonine kinase 1 Homo sapiens 136-139 34630074-8 2021 It was determined that gracillin could fight against gastric cancer cells by inhibiting the cell proliferation participated by the PI3K/AKT pathway and cell cycle arrest, suppressing the EMT pathway-regulating cell migration, and inducing bcl2-associated mitochondrial apoptosis. gracillin 23-32 BCL2 apoptosis regulator Homo sapiens 239-243 35392243-0 2022 Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway. gracillin 0-9 mechanistic target of rapamycin kinase Mus musculus 93-97 35392243-8 2022 The further mechanism study found that the mTOR signaling pathway was significantly inhibited by gracillin. gracillin 97-106 mechanistic target of rapamycin kinase Mus musculus 43-47 35392243-10 2022 Meanwhile, LC3-II transformation was found to be significantly reduced after WIPI1 was silenced in A549 cells but increased after gracillin treatment. gracillin 130-139 microtubule-associated protein 1 light chain 3 alpha Mus musculus 11-14 35392243-14 2022 The mechanism maybe that gracillin inhibited the mTOR signaling pathway. gracillin 25-34 mechanistic target of rapamycin kinase Mus musculus 49-53