PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 17287417-9 2007 RESULTS: Adiponectin and ghrelin levels correlated significantly with most metabolic markers of insulin resistance and with serum levels of DHEA and 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 149-171 adiponectin, C1Q and collagen domain containing Homo sapiens 9-20 16984992-4 2006 RESULTS: Analyzing the mutations in vitro revealed an almost absent or negligible CYP21 activity for the conversion of 17-hydroxyprogesterone to 11-deoxycortisol and progesterone to deoxycorticosterone. 17-alpha-Hydroxyprogesterone 119-141 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 82-87 17628913-13 2007 In fully genotyped NC patients, the lowest value of ACTH-stimulated 17OHP was 14 ng/ml. 17-alpha-Hydroxyprogesterone 68-73 proopiomelanocortin Homo sapiens 52-56 17221119-3 2006 A case of a patient with hirsutism and a high basal and post-ACTH stimulation concentration of 17-OHP is presented. 17-alpha-Hydroxyprogesterone 95-101 proopiomelanocortin Homo sapiens 61-65 17496421-3 2007 In addition, elevated 17alpha-hydroxyprogesterone and androstenedione levels due to peripheral HSD3B1 activity may lead to a delay of the correct diagnosis and even to misdiagnosis as CYP21 deficiency. 17-alpha-Hydroxyprogesterone 22-49 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 95-101 16601134-3 2006 Cyp17 mRNA endogenously expressed by AC cells was suppressed by activins A and B and BMP-2, -6, and -7, and each ligand accordingly inhibited 17alpha-hydroxyprogesterone production (IC(50) of 0.24, 0.27, 0.4, 0.51, and 2.2 nm, respectively). 17-alpha-Hydroxyprogesterone 142-169 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 0-5 16794007-9 2006 Furthermore, progesterone and 17 alpha-hydroxy-progesterone stimulated intracellular Ca2+ mobilization in CHO cells that expressed ovine mPR in Ca2+-free medium (P < 0.05) but not in CHO cells transfected with empty vector. 17-alpha-Hydroxyprogesterone 30-59 progestin and adipoQ receptor family member VII Mus musculus 137-140 16342524-11 2005 CONCLUSIONS AND CLINICAL RELEVANCE: Serum concentrations of 17OHP or corticosterone after administration of ACTH may be high in dogs with nonadrenal neoplasia and no evidence of hyperadrenocorticism. 17-alpha-Hydroxyprogesterone 60-65 proopiomelanocortin Canis lupus familiaris 108-112 16597434-1 2006 Steroid 21-hydroxylase, P450c21, is responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their 21-hydroxylated derivatives. 17-alpha-Hydroxyprogesterone 87-114 LOC107131127 Bos taurus 0-22 16597434-1 2006 Steroid 21-hydroxylase, P450c21, is responsible for the conversion of progesterone and 17alpha-hydroxyprogesterone to their 21-hydroxylated derivatives. 17-alpha-Hydroxyprogesterone 87-114 steroid 21-hydroxylase Bos taurus 24-31 16595705-7 2006 The effect of substrate on the redox potential for each P450c17 was measured in the presence of pregnenolone, progesterone, 17alpha-hydroxypregnenolone and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 156-183 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 56-63 16258004-0 2006 Congenital adrenal hyperplasia: family screening using 17-hydroxyprogesterone (17-OHP) response to adrenocorticotropin (ACTH). 17-alpha-Hydroxyprogesterone 55-77 proopiomelanocortin Homo sapiens 120-124 16258004-0 2006 Congenital adrenal hyperplasia: family screening using 17-hydroxyprogesterone (17-OHP) response to adrenocorticotropin (ACTH). 17-alpha-Hydroxyprogesterone 79-85 proopiomelanocortin Homo sapiens 120-124 16342524-12 2005 Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration. 17-alpha-Hydroxyprogesterone 17-22 proopiomelanocortin Canis lupus familiaris 80-84 16220669-0 2005 Evaluation of serum 17-hydroxyprogesterone concentration after administration of ACTH in dogs with hyperadrenocorticism. 17-alpha-Hydroxyprogesterone 20-42 proopiomelanocortin Canis lupus familiaris 81-85 16613821-7 2005 She had an exaggerated response of 17OH progesterone to ACTH, implying reduced 21-hydroxylase activity. 17-alpha-Hydroxyprogesterone 35-52 proopiomelanocortin Homo sapiens 56-60 16220669-9 2005 Frequency intervals of serum 17-OHP concentrations after ACTH stimulation were < 77, < 2.0, < 3.2, and < 3.4 ng/mL (< 23.3, < 6.1, < 9.7, and < 10.3 nmol/L) for sexually intact and neutered females and sexually intact and neutered males, respectively. 17-alpha-Hydroxyprogesterone 29-35 proopiomelanocortin Canis lupus familiaris 57-61 15956788-10 2005 Insulin levels were correlated with fT and 17-OHP (p < 0.05). 17-alpha-Hydroxyprogesterone 43-49 insulin Homo sapiens 0-7 16200845-11 2005 Serum leptin levels were influenced by BMI (p = 0.001), basal 17-OHP (p = 0.002) and stimulated 17-OHP (p = 0.019) in patients with PA. 17-alpha-Hydroxyprogesterone 62-68 leptin Homo sapiens 6-12 16200845-11 2005 Serum leptin levels were influenced by BMI (p = 0.001), basal 17-OHP (p = 0.002) and stimulated 17-OHP (p = 0.019) in patients with PA. 17-alpha-Hydroxyprogesterone 96-102 leptin Homo sapiens 6-12 15914530-6 2005 Uptake of iodocholesterol by the adrenal tumor in case 1 and elevated plasma ACTH-stimulated 17-hydroxyprogesterone values in case 2 strongly argued for the diagnosis of primary adrenocortical tumors. 17-alpha-Hydroxyprogesterone 93-115 proopiomelanocortin Homo sapiens 77-81 15855259-8 2005 Stimulated 17OH progesterone (17OHProg) increased throughout puberty only in girls with DM1 (ANOVA, P < 0.01). 17-alpha-Hydroxyprogesterone 11-28 immunoglobulin heavy diversity 1-7 Homo sapiens 88-91 15855259-8 2005 Stimulated 17OH progesterone (17OHProg) increased throughout puberty only in girls with DM1 (ANOVA, P < 0.01). 17-alpha-Hydroxyprogesterone 30-38 immunoglobulin heavy diversity 1-7 Homo sapiens 88-91 15855259-9 2005 Girls with DM1 at Tanner stage 5 had higher stimulated LH to FSH ratio, testosterone, and 17OHProg levels than girls at Tanner stage 4. 17-alpha-Hydroxyprogesterone 90-98 immunoglobulin heavy diversity 1-7 Homo sapiens 11-14 15640159-1 2005 The enzyme CYP17 primarily regulates androgen production by mediating four reactions: conversion of pregnenolone and progesterone to 17-hydroxypregnenolone and 17-hydroxyprogesterone, respectively (17alpha-hydroxylase activity), followed by conversion of the 17-hydroxylated steroids to dehydroepiandrosterone and androstenedione, respectively (17,20-lyase activity). 17-alpha-Hydroxyprogesterone 160-182 cytochrome P450 family 17 subfamily A member 1 L homeolog Xenopus laevis 11-16 15194576-8 2004 In both patient groups, serum leptin levels correlated negatively with the molar ratio of serum ASD/serum cortisol and serum ASD/serum 17OHP, and positively with the molar ratio of serum DHEA/serum ASD. 17-alpha-Hydroxyprogesterone 135-140 leptin Homo sapiens 30-36 15555913-6 2004 Quantitative analyses of steroid production by Cyp17 showed that cAMP decreased the amount of 17-hydroxyprogesterone produced relative to the androstenedione, suggesting that cAMP signaling lowers the efficiency of the Cyp17 hydroxylase activity or else increases the efficiency of its lyase activity. 17-alpha-Hydroxyprogesterone 94-116 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 47-52 15555913-6 2004 Quantitative analyses of steroid production by Cyp17 showed that cAMP decreased the amount of 17-hydroxyprogesterone produced relative to the androstenedione, suggesting that cAMP signaling lowers the efficiency of the Cyp17 hydroxylase activity or else increases the efficiency of its lyase activity. 17-alpha-Hydroxyprogesterone 94-116 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 219-224 15347444-12 2004 An ACTH stimulation test indicated basal serum dehydroepiandrosterone and 17-hydroxyprogesterone were lower than normal detectable range and had no obvious increase after the ACTH stimulation. 17-alpha-Hydroxyprogesterone 74-96 proopiomelanocortin Homo sapiens 3-7 15256784-1 2004 ACTH and 17-hydroxyprogesterone (17OHP) levels during clitoro- and labinoplasty for CYP21A2 deficiency have not been reported. 17-alpha-Hydroxyprogesterone 9-31 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 84-91 15256784-1 2004 ACTH and 17-hydroxyprogesterone (17OHP) levels during clitoro- and labinoplasty for CYP21A2 deficiency have not been reported. 17-alpha-Hydroxyprogesterone 33-38 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 84-91 14563706-3 2004 Rat CYP2D4 and human CYP2D6, which are the predominant CYP2D isoforms in the brain, possess 21-hydroxylation activity for both progesterone and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 144-171 cytochrome P450, family 2, subfamily d, polypeptide 4 Rattus norvegicus 4-10 14563706-3 2004 Rat CYP2D4 and human CYP2D6, which are the predominant CYP2D isoforms in the brain, possess 21-hydroxylation activity for both progesterone and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 144-171 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 21-27 15106361-7 2004 Interestingly, TIMP-2 expression was down-regulated by 17 beta-estradiol and 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 77-105 TIMP metallopeptidase inhibitor 2 Homo sapiens 15-21 14563706-3 2004 Rat CYP2D4 and human CYP2D6, which are the predominant CYP2D isoforms in the brain, possess 21-hydroxylation activity for both progesterone and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 144-171 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 4-9 24790299-5 2004 The patient had a increase in serum 17alpha-hydroxy progesterone levels (basal 4.9 37 ng/ml after a single 0.25 mg/m(2) infusion of ACTH), but the increase in adrenal androgen was not sufficient to virilize the external genitalia. 17-alpha-Hydroxyprogesterone 36-64 proopiomelanocortin Homo sapiens 134-138 14657608-5 2003 In vitro studies in purified Leydig cells from normal (CTR) and MSG-damaged rats revealed that basal and human chorionic gonadotropin (hCG)-stimulated 17-hydroxy-progesterone (17-HO-P(4)), Delta(4)-androstenedione (Delta(4)A) and testosterone (T) secretions were significantly lower in MSG than in CTR cells. 17-alpha-Hydroxyprogesterone 151-174 calcitonin receptor Homo sapiens 298-301 14504283-6 2003 In contrast, mutation E305G exhibits 11-fold greater catalytic efficiency (kcat/Km) for the cleavage of 17alpha-hydroxyprogesterone to androstenedione compared with wild-type CYP17. 17-alpha-Hydroxyprogesterone 104-131 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 175-180 14522586-8 2003 The brisk metabolism of 5alpha-pregnan-3alpha,17alpha-diol-20-one to androsterone by CYP17 explains how, when 5alpha-reductases are present, the testis can produce C(19) steroids androsterone and androstanediol from 17alpha-hydroxyprogesterone without the intermediacy of androstenedione and testosterone. 17-alpha-Hydroxyprogesterone 216-243 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 85-90 14568566-9 2003 Culture experiments demonstrated that 17alpha-hydroxyprogesterone and testosterone (T) secretion levels increased in the presence of IGF-I on days E11-E17. 17-alpha-Hydroxyprogesterone 38-65 insulin-like growth factor 1 Mus musculus 133-138 14523365-2 2003 Abnormal regulation of cytochrome P450 17 alpha is believed to cause the exaggerated 17-hydroxyprogesterone (17OHP) response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 85-107 proopiomelanocortin Homo sapiens 128-132 14523365-2 2003 Abnormal regulation of cytochrome P450 17 alpha is believed to cause the exaggerated 17-hydroxyprogesterone (17OHP) response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 109-114 proopiomelanocortin Homo sapiens 128-132 14523365-11 2003 CONCLUSIONS: These data suggest that the exaggerated 17-hydroxyprogesterone (17OHP) response to ACTH stimulation in PCOS is revealed by stimulation at a pharmacological dose (250 microg) but not by a physiological dose (1 microg). 17-alpha-Hydroxyprogesterone 53-75 proopiomelanocortin Homo sapiens 96-100 14523365-11 2003 CONCLUSIONS: These data suggest that the exaggerated 17-hydroxyprogesterone (17OHP) response to ACTH stimulation in PCOS is revealed by stimulation at a pharmacological dose (250 microg) but not by a physiological dose (1 microg). 17-alpha-Hydroxyprogesterone 77-82 proopiomelanocortin Homo sapiens 96-100 12727943-3 2003 To evaluate the meaning of such findings, we investigated the response of aldosterone, cortisol, and 17OH progesterone (17OHP) to 1 microg ACTH in 42 patients with adrenocortical tumors (23 NHAs, 9 APAs, and 10 CPAs) and 10 normal subjects (C). 17-alpha-Hydroxyprogesterone 101-118 proopiomelanocortin Homo sapiens 139-143 12727943-7 2003 17OHP peak levels were significantly higher in patients with adrenocortical tumors toward C. In summary: 1) low-dose ACTH induces an important stimulation in all tumors, suggesting preservation of high responsiveness to ACTH; 2) this is especially true for aldosterone in APA and could be of primary importance when performing diagnostic tests for hyperaldosteronism; and 3) 17OHP-hyperresponsiveness to low-dose ACTH is the most common alteration both in functional and nonfunctional tumors. 17-alpha-Hydroxyprogesterone 0-5 proopiomelanocortin Homo sapiens 117-121 12727943-7 2003 17OHP peak levels were significantly higher in patients with adrenocortical tumors toward C. In summary: 1) low-dose ACTH induces an important stimulation in all tumors, suggesting preservation of high responsiveness to ACTH; 2) this is especially true for aldosterone in APA and could be of primary importance when performing diagnostic tests for hyperaldosteronism; and 3) 17OHP-hyperresponsiveness to low-dose ACTH is the most common alteration both in functional and nonfunctional tumors. 17-alpha-Hydroxyprogesterone 0-5 proopiomelanocortin Homo sapiens 220-224 12727943-7 2003 17OHP peak levels were significantly higher in patients with adrenocortical tumors toward C. In summary: 1) low-dose ACTH induces an important stimulation in all tumors, suggesting preservation of high responsiveness to ACTH; 2) this is especially true for aldosterone in APA and could be of primary importance when performing diagnostic tests for hyperaldosteronism; and 3) 17OHP-hyperresponsiveness to low-dose ACTH is the most common alteration both in functional and nonfunctional tumors. 17-alpha-Hydroxyprogesterone 0-5 proopiomelanocortin Homo sapiens 220-224 12727943-7 2003 17OHP peak levels were significantly higher in patients with adrenocortical tumors toward C. In summary: 1) low-dose ACTH induces an important stimulation in all tumors, suggesting preservation of high responsiveness to ACTH; 2) this is especially true for aldosterone in APA and could be of primary importance when performing diagnostic tests for hyperaldosteronism; and 3) 17OHP-hyperresponsiveness to low-dose ACTH is the most common alteration both in functional and nonfunctional tumors. 17-alpha-Hydroxyprogesterone 375-380 proopiomelanocortin Homo sapiens 117-121 12605347-13 2003 Furthermore, urinary steroid profile and/or CYP21 gene analysis are needed in patients with a stimulated 17-OHP value between 10 and 30 ng/ml. 17-alpha-Hydroxyprogesterone 105-111 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 44-49 12727972-5 2003 Steroid hormone production (cortisol, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate) in NCI-h295 cells was decreased by 1-28-POMC in a concentration-dependent fashion. 17-alpha-Hydroxyprogesterone 38-60 proopiomelanocortin Homo sapiens 138-142 12464253-4 2003 Ovine CYP17 expressed in HEK 293 cells converts progesterone to 17-hydroxyprogesterone and pregnenolone to dehydroepiandrosterone via 17-hydroxypregnenolone. 17-alpha-Hydroxyprogesterone 64-86 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 6-11 12711006-5 2003 Therefore, progesterone and 17alpha-hydroxyprogesterone as endogenous steroids might induce PD-ECGF-related angiogenic potential in uterine endometrial cancer cells, but not MPA as a synthetic steroid. 17-alpha-Hydroxyprogesterone 28-55 thymidine phosphorylase Homo sapiens 92-99 12693981-4 2003 Highly purified cytochromes P45017alpha were used for determination of enzyme activity and specificity in relation to progesterone, pregnenolone, 17alpha-hydroxyprogesterone, and 17alpha-hydroxypregnenolone with registration of the kinetics of reaction product formation using HPLC. 17-alpha-Hydroxyprogesterone 146-173 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 28-39 12050262-12 2002 Treatment of human thecal cells with GDF-9 blocked forskolin-stimulated progesterone, 17alpha-hydroxyprogesterone, and dehydroepiandrosterone synthesis. 17-alpha-Hydroxyprogesterone 86-113 growth differentiation factor 9 Homo sapiens 37-42 12435797-4 2002 Both 17 alpha-hydroxyprogesterone (17OHP) and 20 alpha-hydroxyprogesterone (20OHP) antagonized the aldosterone-induced trans-activation activity (IC(50): 17OHP, 10(-7) M; 20OHP, 10(-8) M) of the hMR transiently expressed in COS-7 cells lacking steroid receptors. 17-alpha-Hydroxyprogesterone 5-33 mannose receptor C-type 1 Homo sapiens 195-198 12435797-4 2002 Both 17 alpha-hydroxyprogesterone (17OHP) and 20 alpha-hydroxyprogesterone (20OHP) antagonized the aldosterone-induced trans-activation activity (IC(50): 17OHP, 10(-7) M; 20OHP, 10(-8) M) of the hMR transiently expressed in COS-7 cells lacking steroid receptors. 17-alpha-Hydroxyprogesterone 35-40 mannose receptor C-type 1 Homo sapiens 195-198 12435797-4 2002 Both 17 alpha-hydroxyprogesterone (17OHP) and 20 alpha-hydroxyprogesterone (20OHP) antagonized the aldosterone-induced trans-activation activity (IC(50): 17OHP, 10(-7) M; 20OHP, 10(-8) M) of the hMR transiently expressed in COS-7 cells lacking steroid receptors. 17-alpha-Hydroxyprogesterone 8-33 mannose receptor C-type 1 Homo sapiens 195-198 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). 17-alpha-Hydroxyprogesterone 136-153 interleukin 6 Homo sapiens 19-23 12429044-9 2002 The ratio of serum IL-6/TNF was positively correlated with the ratio of serum cortisol/DHEA (R(Rank)=0.472, P=0.041) and serum cortisol/17OH-progesterone (R(Rank)=0.514, P=0.048). 17-alpha-Hydroxyprogesterone 136-153 tumor necrosis factor Homo sapiens 24-27 12213672-9 2002 ACTH-stimulated plasma 17-OHP concentrations were above 1500 ng/dl in all patients with bilateral incidentalomas who had homozygous and heterozygous CYP21 mutations, but heterozygous carriers with unilateral incidentalomas had highly variable ACTH-stimulated plasma 17-OHP levels (between 111 and 1705 ng/dl). 17-alpha-Hydroxyprogesterone 23-29 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 149-154 12208672-7 2002 Further analysis in ACTH-stimulated bovine adrenal cells using stable isotope dilution/gas chromatography-mass spectrometry demonstrated CLO-induced inhibition of adrenal 21-hydroxylase (P450c21) activity leading to a dose-dependent increase in the 17-OH-progesterone/11-deoxycortisol ratio. 17-alpha-Hydroxyprogesterone 249-267 steroid 21-hydroxylase Bos taurus 187-194 12534357-6 2003 CONCLUSIONS: A beta-adrenergic influence seems to decrease CRH-stimulated cortisol in relation to ACTH and 17OHP, and decreases DHEAS in relation to DHEA. 17-alpha-Hydroxyprogesterone 107-112 amyloid beta precursor protein Homo sapiens 13-19 12534357-6 2003 CONCLUSIONS: A beta-adrenergic influence seems to decrease CRH-stimulated cortisol in relation to ACTH and 17OHP, and decreases DHEAS in relation to DHEA. 17-alpha-Hydroxyprogesterone 107-112 corticotropin releasing hormone Homo sapiens 59-62 12530700-5 2002 Therefore, we tested the hypothesis that elevated ACTH-stimulated 17-OHP (delta > 2.6 ng/mL) can predict primary adrenal lesions. 17-alpha-Hydroxyprogesterone 66-72 proopiomelanocortin Homo sapiens 50-54 12429044-10 2002 In conclusion, dissociation of cortisol relative to DHEA, DHEAS or 17OH-progesterone appears very early during a systemic inflammatory response which is associated with an increase of IL-6 relative to TNF. 17-alpha-Hydroxyprogesterone 67-84 interleukin 6 Homo sapiens 184-188 11932321-5 2002 The proband was born with ambiguous genitalia from consanguineous parents and was mistreated as a 21-hydroxylase deficiency case since the age of 5 yr. She had very high levels of plasma ACTH (759 pg/ml or 167 pmol/liter) and high levels of cortisol (28-54 microg/dl or 772-1490 nmol/liter), androstenedione (5-14 ng/ml or 17-48 nmol/liter), T (174-235 ng/dl or 7-8 nmol/liter), and 17-hydroxyprogesterone (8-12 ng/ml or 24-36 nmol/liter). 17-alpha-Hydroxyprogesterone 383-405 proopiomelanocortin Homo sapiens 187-191 11925385-9 2002 The ACTH-stimulated concentration of progesterone and of 17alpha-hydroxyprogesterone were significantly reduced during intake of ethinyl estradiol. 17-alpha-Hydroxyprogesterone 57-84 proopiomelanocortin Homo sapiens 4-8 11889187-4 2002 The cortisol and 17-hydroxyprogesterone (17-OHP) responses to 1 microg/kg ACTH were analyzed in relation to birth weight SD scores (BW-SDS) corrected for gestational age, gender, and parity. 17-alpha-Hydroxyprogesterone 17-39 proopiomelanocortin Homo sapiens 74-78 11950017-15 2002 In contrast, ACTH induced a significantly higher (p < 0.05) peak of 17-OHP and AUC in PMR patients than in controls. 17-alpha-Hydroxyprogesterone 71-77 proopiomelanocortin Homo sapiens 13-17 11950017-17 2002 The defect seems mainly related to altered adrenal responsiveness to the ACTH stimulation (i.e., increased 17-OHP), at least in untreated patients. 17-alpha-Hydroxyprogesterone 107-113 proopiomelanocortin Homo sapiens 73-77 11920401-4 2002 However, in RA and ReA patients compared with healthy subjects, levels of ACTH, cortisol, ASD, DHEAS, and 17-OH-progesterone were markedly lower in relation to levels of IL-6 and TNF. 17-alpha-Hydroxyprogesterone 106-124 interleukin 6 Homo sapiens 170-174 11920401-4 2002 However, in RA and ReA patients compared with healthy subjects, levels of ACTH, cortisol, ASD, DHEAS, and 17-OH-progesterone were markedly lower in relation to levels of IL-6 and TNF. 17-alpha-Hydroxyprogesterone 106-124 tumor necrosis factor Homo sapiens 179-182 11889187-4 2002 The cortisol and 17-hydroxyprogesterone (17-OHP) responses to 1 microg/kg ACTH were analyzed in relation to birth weight SD scores (BW-SDS) corrected for gestational age, gender, and parity. 17-alpha-Hydroxyprogesterone 41-47 proopiomelanocortin Homo sapiens 74-78 11889187-9 2002 We conclude that the response of cortisol and 17-OHP to ACTH stimulation in preterm infants is related to fetal growth. 17-alpha-Hydroxyprogesterone 46-52 proopiomelanocortin Homo sapiens 56-60 12008748-1 2002 The current study aimed to investigate the midterm (24 hour) response of 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEA-S) to synthetic high-dose adrenocorticotropin (ACTH) in adrenal incidentalomas (Al). 17-alpha-Hydroxyprogesterone 73-95 proopiomelanocortin Homo sapiens 194-198 12008748-9 2002 Three of the patients were found to have subclinical Cushing"s syndrome and interestingly, two augmented their 17-OHP response to ACTH after unilateral adrenalectomy and normalisation of their HPA axis. 17-alpha-Hydroxyprogesterone 111-117 proopiomelanocortin Homo sapiens 130-134 12008748-11 2002 Evidence of a heterozygous 21 hydroxylase deficiency, as indicated by the exaggerated 17-OHP response to ACTH, has been widely reported in Al patients. 17-alpha-Hydroxyprogesterone 86-92 proopiomelanocortin Homo sapiens 105-109 12008748-12 2002 However, to our knowledge to date there is no report on augmented 17-OHP response to ACTH after adrenalectomy. 17-alpha-Hydroxyprogesterone 66-72 proopiomelanocortin Homo sapiens 85-89 11915581-8 2002 In the nafarelin test increases of 17-OH-progesterone and androstenedione were higher in patients and positively correlated with fasting insulin levels. 17-alpha-Hydroxyprogesterone 35-53 insulin Homo sapiens 137-144 11595505-10 2001 In response to corticotropin-releasing factor test, plasma levels of ACTH, cortisol, 17-OHP, 11-deoxycortisol, DHEA and androstenedione were significantly lower in patients than in controls. 17-alpha-Hydroxyprogesterone 85-91 corticotropin releasing hormone Homo sapiens 15-45 12222711-0 2002 Non-classical 21-hydroxylase deficiency in children: association of adrenocorticotropic hormone-stimulated 17-hydroxyprogesterone with the risk of compound heterozygosity with severe mutations. 17-alpha-Hydroxyprogesterone 107-129 proopiomelanocortin Homo sapiens 68-95 12222711-9 2002 The degree of enzymic deficiency, as measured by basal or adrenocorticotropic hormone (ACTH)-stimulated 17-OHP levels in fully genotyped patients, but not clinical severity (age and number of symptoms at diagnosis), was found to be significantly greater in children with the severe/mild genotype. 17-alpha-Hydroxyprogesterone 104-110 proopiomelanocortin Homo sapiens 58-85 12222711-9 2002 The degree of enzymic deficiency, as measured by basal or adrenocorticotropic hormone (ACTH)-stimulated 17-OHP levels in fully genotyped patients, but not clinical severity (age and number of symptoms at diagnosis), was found to be significantly greater in children with the severe/mild genotype. 17-alpha-Hydroxyprogesterone 104-110 proopiomelanocortin Homo sapiens 87-91 12222711-10 2002 ROC curve analyses revealed a strong association between ACTH-17-OHP and genotype (area under the curve 0.908, SE 0.057). 17-alpha-Hydroxyprogesterone 62-68 proopiomelanocortin Homo sapiens 57-61 11779609-7 2002 RESULT(S): Prenatally androgenized females exhibited increased T and 17alpha-hydroxyprogesterone response to recombinant hCG stimulation, compared to control females. 17-alpha-Hydroxyprogesterone 69-96 hypertrichosis 2 (generalised, congenital) Homo sapiens 121-124 11836321-0 2002 Variable ACTH-stimulated 17-hydroxyprogesterone values in 21-hydroxylase deficiency carriers are not related to the different CYP21 gene mutations. 17-alpha-Hydroxyprogesterone 25-47 proopiomelanocortin Homo sapiens 9-13 11836321-1 2002 The currently used cutoff level for ACTH-stimulated 17- hydroxyprogesterone (17OHP) for the diagnosis of the nonclassical (NC) form of 21-hydroxylase deficiency (21OHD), established before molecular studies, is based on the mean + 2 SD of 17OHP levels of obligate heterozygotes. 17-alpha-Hydroxyprogesterone 52-75 proopiomelanocortin Homo sapiens 36-40 11836321-1 2002 The currently used cutoff level for ACTH-stimulated 17- hydroxyprogesterone (17OHP) for the diagnosis of the nonclassical (NC) form of 21-hydroxylase deficiency (21OHD), established before molecular studies, is based on the mean + 2 SD of 17OHP levels of obligate heterozygotes. 17-alpha-Hydroxyprogesterone 77-82 proopiomelanocortin Homo sapiens 36-40 11836321-1 2002 The currently used cutoff level for ACTH-stimulated 17- hydroxyprogesterone (17OHP) for the diagnosis of the nonclassical (NC) form of 21-hydroxylase deficiency (21OHD), established before molecular studies, is based on the mean + 2 SD of 17OHP levels of obligate heterozygotes. 17-alpha-Hydroxyprogesterone 239-244 proopiomelanocortin Homo sapiens 36-40 11836321-2 2002 However, carriers of CYP21 mutations present variable ACTH-stimulated 17OHP levels, ranging from normal values up to 30 nmol/liter. 17-alpha-Hydroxyprogesterone 70-75 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 21-26 11836321-2 2002 However, carriers of CYP21 mutations present variable ACTH-stimulated 17OHP levels, ranging from normal values up to 30 nmol/liter. 17-alpha-Hydroxyprogesterone 70-75 proopiomelanocortin Homo sapiens 54-58 11836321-3 2002 The aim of this study was to determine whether ACTH-stimulated 17OHP levels in obligate carriers for 21OHD would be correlated with the impairment of the enzyme activity caused by these mutations, which would affect the 17OHP cutoff level for the diagnosis of the NC form. 17-alpha-Hydroxyprogesterone 63-68 proopiomelanocortin Homo sapiens 47-51 11836321-3 2002 The aim of this study was to determine whether ACTH-stimulated 17OHP levels in obligate carriers for 21OHD would be correlated with the impairment of the enzyme activity caused by these mutations, which would affect the 17OHP cutoff level for the diagnosis of the NC form. 17-alpha-Hydroxyprogesterone 220-225 proopiomelanocortin Homo sapiens 47-51 11836321-9 2002 ACTH-stimulated 17OHP levels identified 39% of the carriers (9 in group A, 2 in group B and 12 in group C). 17-alpha-Hydroxyprogesterone 16-21 proopiomelanocortin Homo sapiens 0-4 11836321-11 2002 Two carriers presented ACTH-stimulated 17OHP levels between 30 and 45 nmol/liter and their entire CYP21 sequencing revealed only one mutation in heterozygous state indicating that the current cutoff level might overestimate the diagnosis of the NC form. 17-alpha-Hydroxyprogesterone 39-44 proopiomelanocortin Homo sapiens 23-27 11836321-12 2002 We conclude that the variable ACTH-stimulated 17-OHP levels in carriers are not related to CYP21 gene mutations with different impairment of enzyme activity. 17-alpha-Hydroxyprogesterone 46-52 proopiomelanocortin Homo sapiens 30-34 12222711-11 2002 CONCLUSION: ACTH-stimulated 17-OHP may predict the risk of severe mutations in compound heterozygosity in children (maximum predictive value 93% sensitivity and 83% specificity for a cut-off at 151 nmol l(-1)), although a certain overlap in individual values is observed and performance of molecular analysis should never be obviated in the genetic counselling of these patients. 17-alpha-Hydroxyprogesterone 28-34 proopiomelanocortin Homo sapiens 12-16 12053092-4 2002 RESULTS: In patients with nonfunctioning lesions, the ACTH test induced 17-OHP and S peaks higher than in normals (p < 0.005). 17-alpha-Hydroxyprogesterone 72-78 proopiomelanocortin Homo sapiens 54-58 12053092-6 2002 In patients with subclinical Cushing"s syndrome, the 17-OHP peak after ACTH was greater than in patients with nonfunctioning lesions and in normals (p < 0.005); the S peak was also higher than in controls (p < 0.005). 17-alpha-Hydroxyprogesterone 53-59 proopiomelanocortin Homo sapiens 71-75 11817708-10 2001 A significant difference in the size of the lesions was observed between patients with or without 17-OHP hyperresponse to ACTH test (31.1 1.9 vs 24.1 +/- 1.2 mm; p<0.01). 17-alpha-Hydroxyprogesterone 98-104 proopiomelanocortin Homo sapiens 122-126 11747281-5 2001 The 17-OHP response to ACTH stimulation was significantly higher in patients with adrenal incidentalomas than in control subjects (P<0.001). 17-alpha-Hydroxyprogesterone 4-10 proopiomelanocortin Homo sapiens 23-27 11747281-8 2001 In 13 patients, stimulated DHEAS levels were low in association with high 17-OHP levels. 17-alpha-Hydroxyprogesterone 74-80 sulfotransferase family 2A member 1 Homo sapiens 27-32 11357057-15 2001 PP2 treatment for 48 h caused an increase in the conversion of progesterone to 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 79-106 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 0-3 11465355-0 2001 Ovulation rate and litter size in gilts immunized against androstenedione and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 78-105 Ovulation rate Sus scrofa 0-14 11248089-4 2001 There was also a slight decrease in 17-OH-progesterone compared to the more significant decrease in testosterone, suggesting that MIS might be regulating the lyase activity of cytochrome P450c17 hydroxylase/lyase (Cyp17), but not its hydroxylase activity. 17-alpha-Hydroxyprogesterone 36-54 anti-Mullerian hormone Mus musculus 130-133 11359457-6 2001 A reliable and accurate detection of CYP21 mutations is not only important for clinical diagnosis, but also for carrier detection as there is a high variability in the basal level of 17-hydroxyprogesterone between normal and heterozygous individuals. 17-alpha-Hydroxyprogesterone 183-205 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 37-42 11248089-4 2001 There was also a slight decrease in 17-OH-progesterone compared to the more significant decrease in testosterone, suggesting that MIS might be regulating the lyase activity of cytochrome P450c17 hydroxylase/lyase (Cyp17), but not its hydroxylase activity. 17-alpha-Hydroxyprogesterone 36-54 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 214-219 11294032-13 2001 The characteristics of the extraovarian POS include the 17-hydroxyprogesterone elevation in response to the ACTH test and the dexamethasone suppression of adrenal androgens. 17-alpha-Hydroxyprogesterone 56-78 proopiomelanocortin Homo sapiens 108-112 10999829-12 2000 In contrast, BMP-4 decreased forskolin-stimulated HOTT cell secretion of androstenedione and 17OHP by 50% but increased progesterone production 3-fold above forskolin treatment alone. 17-alpha-Hydroxyprogesterone 93-98 bone morphogenetic protein 4 Homo sapiens 13-18 11109974-22 2000 Before treatment, ACTH stimulus induced a significant response in all parameters; after the treatment, it prompted a greater response in delta 5- and delta 4-androgens, progesterone and 17-OH progesterone, while cortisol responded less in both younger and older normal-weight women. 17-alpha-Hydroxyprogesterone 186-204 proopiomelanocortin Homo sapiens 18-22 11022183-2 2000 DESIGN: Genotyping for mutations in the steroid 21-hydroxylase (CYP21) gene was performed in 45 unrelated Israeli Jewish patients (nine males) with NC21-OHD (60min 17-hydroxyprogesterone (17-OHP), 45-386nmol/l) who were referred for evaluation of postnatal virilization or true precocious/early puberty. 17-alpha-Hydroxyprogesterone 164-186 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 40-62 11022183-2 2000 DESIGN: Genotyping for mutations in the steroid 21-hydroxylase (CYP21) gene was performed in 45 unrelated Israeli Jewish patients (nine males) with NC21-OHD (60min 17-hydroxyprogesterone (17-OHP), 45-386nmol/l) who were referred for evaluation of postnatal virilization or true precocious/early puberty. 17-alpha-Hydroxyprogesterone 164-186 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 64-69 11022183-2 2000 DESIGN: Genotyping for mutations in the steroid 21-hydroxylase (CYP21) gene was performed in 45 unrelated Israeli Jewish patients (nine males) with NC21-OHD (60min 17-hydroxyprogesterone (17-OHP), 45-386nmol/l) who were referred for evaluation of postnatal virilization or true precocious/early puberty. 17-alpha-Hydroxyprogesterone 188-194 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 40-62 11022183-2 2000 DESIGN: Genotyping for mutations in the steroid 21-hydroxylase (CYP21) gene was performed in 45 unrelated Israeli Jewish patients (nine males) with NC21-OHD (60min 17-hydroxyprogesterone (17-OHP), 45-386nmol/l) who were referred for evaluation of postnatal virilization or true precocious/early puberty. 17-alpha-Hydroxyprogesterone 188-194 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 64-69 10704913-4 1999 The influence of the kinetic properties of 3beta-HSD in the accumulation of 17alpha-hydroxyprogesterone was probed by co-expression of the bovine 17alpha-hydroxylase cytochrome P450 (P45017alpha) cDNA. 17-alpha-Hydroxyprogesterone 76-103 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase Bos taurus 43-52 10882146-1 2000 Patients with non-hyperfunctioning adrenal adenomas often have an increased plasma 17-hydroxyprogesterone response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 83-105 proopiomelanocortin Homo sapiens 118-122 10882146-5 2000 Basal and ACTH-stimulated plasma 17-hydroxyprogesterone and cortisol concentrations are reported. 17-alpha-Hydroxyprogesterone 33-55 proopiomelanocortin Homo sapiens 10-14 10882146-7 2000 However, the ACTH-stimulated plasma 17-hydroxyprogesterone levels were abnormally increased in 53% and 31% of patients with non-hyperfunctioning adenomas and aldosterone-producing adenomas, respectively. 17-alpha-Hydroxyprogesterone 36-58 proopiomelanocortin Homo sapiens 13-17 10882146-8 2000 In addition, a few patients with adrenal cysts and pheochromocytomas also showed an increased ACTH-stimulated 17-hydroxyprogesterone response. 17-alpha-Hydroxyprogesterone 110-132 proopiomelanocortin Homo sapiens 94-98 10882146-10 2000 In patients with non-hyperfunctioning adrenal tumors, ACTH-stimulated plasma 17-hydroxyprogesterone and cortisol concentrations significantly correlated with the size of the tumors. 17-alpha-Hydroxyprogesterone 77-99 proopiomelanocortin Homo sapiens 54-58 10882146-11 2000 These results firmly indicate that the tumoral mass itself may be responsible for the increased plasma 17-hydroxyprogesterone and cortisol responses after ACTH stimulation in patients with non-hyperfunctioning and hyperfunctioning adrenal adenomas. 17-alpha-Hydroxyprogesterone 103-125 proopiomelanocortin Homo sapiens 155-159 10523013-11 1999 In all subjects, the percentage increases from baseline in the 17-OH-progesterone to T ratio were directly correlated with leptin levels or FM (r = 0.40 and r = 0.45, P < 0.01), but not with E2 or other hormonal variables. 17-alpha-Hydroxyprogesterone 63-81 leptin Homo sapiens 123-129 10600792-4 1999 hCG stimulation increased peripheral levels of testosterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17beta-estradiol, without affecting circulating pregnenolone and progesterone values. 17-alpha-Hydroxyprogesterone 61-78 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 10600792-6 1999 Moreover, the drug significantly reduced the response of testosterone, 17OH-progesterone, androstenedione, and dehydroepiandrosterone to hCG, as assessed by the mean integrated area under the curve, whereas it did not influence 17beta-estradiol response. 17-alpha-Hydroxyprogesterone 71-88 hypertrichosis 2 (generalised, congenital) Homo sapiens 137-140 10593368-10 1999 The administration of metformin was associated with a significant reduction in the response of 17alpha-hydroxyprogesterone, testosterone, free testosterone, and androstenedione to ACTH. 17-alpha-Hydroxyprogesterone 95-122 proopiomelanocortin Homo sapiens 180-184 10601975-7 1999 The effect of melatonin was probably dependent on the binding of melatonin to its Gi-protein-coupled receptor, as the inhibitory effect on GnRH-induced secretion was supressed in cells pretreated with pertussis toxin in a concentration of 180 ng/ml for 20 h. Assay of 17-hydroxy-progesterone showed that, irrespective of the treatment, cells cultured with melatonin secreted greater amounts than controls. 17-alpha-Hydroxyprogesterone 268-291 gonadotropin releasing hormone 1 Rattus norvegicus 139-143 10537117-9 1999 The inhibitory effect of leptin on hCG-induced T secretion was accompanied by a significant reduction of androstenedione and a concomitant rise of the precursor metabolites pregnenolone, progesterone, and 17-OH-progesterone, conceivable with a leptin-induced lesion of 17,20 lyase activity. 17-alpha-Hydroxyprogesterone 205-223 leptin Rattus norvegicus 25-31 10521100-12 1999 Nine patients without CYP21 mutations had increased ACTH-stimulated 17-hydroxyprogesterone levels; these decreased to normal in six of the patients during gonadal suppression. 17-alpha-Hydroxyprogesterone 68-90 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 22-27 10427156-3 1999 The predictive values of the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation and of HLA typing in screening for carrier status were re-evaluated. 17-alpha-Hydroxyprogesterone 29-51 proopiomelanocortin Homo sapiens 73-77 10468995-4 1999 The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women. 17-alpha-Hydroxyprogesterone 120-142 insulin Homo sapiens 67-74 10468995-4 1999 The aim of the present study was to determine whether reduction of insulin levels by metformin would attenuate FSH, LH, 17-Hydroxyprogesterone (17-OHP) and androstenedione hyperresponsiveness to buserelin testing in PCOS women. 17-alpha-Hydroxyprogesterone 144-150 insulin Homo sapiens 67-74 10427156-3 1999 The predictive values of the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation and of HLA typing in screening for carrier status were re-evaluated. 17-alpha-Hydroxyprogesterone 53-59 proopiomelanocortin Homo sapiens 73-77 10427156-8 1999 The increase in 17-OHP concentrations could be explained by a carrier status for CYP21 gene mutations in only three of 12 patients (25%), whereas seven of 69 patients (10. 17-alpha-Hydroxyprogesterone 16-22 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 81-86 10427156-12 1999 CONCLUSIONS: Basal or ACTH-stimulated 17-OHP concentrations are not a good indicator of the carrier status for 21-hydroxylase deficiency among Slovenian hyperandrogenic patients. 17-alpha-Hydroxyprogesterone 38-44 proopiomelanocortin Homo sapiens 22-26 10372707-17 1999 IGF-I also correlated with the ACTH-stimulated ratios of 17OHPreg/17OHP (r = 0.61; P < 0.05), 17OHPreg/DHEA (r = 0.9; P < 0.001), 17OHP/AS (r = 0.79; P < 0.001), and DHEA/AS (r = 0.96; P < 0.001). 17-alpha-Hydroxyprogesterone 57-62 insulin like growth factor 1 Homo sapiens 0-5 10372707-17 1999 IGF-I also correlated with the ACTH-stimulated ratios of 17OHPreg/17OHP (r = 0.61; P < 0.05), 17OHPreg/DHEA (r = 0.9; P < 0.001), 17OHP/AS (r = 0.79; P < 0.001), and DHEA/AS (r = 0.96; P < 0.001). 17-alpha-Hydroxyprogesterone 66-71 insulin like growth factor 1 Homo sapiens 0-5 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. 17-alpha-Hydroxyprogesterone 97-114 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 19-26 9859027-6 1998 Women with POF showed statistically significantly lower concentrations of 17-OHP, androstenedione and testosterone when compared to fertile controls, while no differences were found between women with POF and postmenopausal women. 17-alpha-Hydroxyprogesterone 74-80 POF1B actin binding protein Homo sapiens 11-14 9768700-0 1998 Increased plasma 17-hydroxyprogesterone response to ACTH in patients with nonhyperfunctioning adrenal adenomas is not due to a deficiency in 21-hydroxylase activity. 17-alpha-Hydroxyprogesterone 17-39 proopiomelanocortin Homo sapiens 52-56 9758440-11 1998 Finally, the mean 17-OHP level in patients with LH levels which induced marked P450 down-regulation (i.e. more than 12 IU/l) was similar to that in patients with LH levels within the normal range (i.e. less than 6 IU/l). 17-alpha-Hydroxyprogesterone 18-24 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 79-83 9798131-12 1998 We were not able to show any critical value for serum basal testosterone and DHEAS levels that would effect response to ACTH stimulation in terms of 17-OHP levels. 17-alpha-Hydroxyprogesterone 149-155 proopiomelanocortin Homo sapiens 120-124 9798131-14 1998 Since serum 17-OHP levels remain within normal limits in response to ACTH stimulation, the origin of elevated serum basal 17-OHP levels may be polycystic ovaries. 17-alpha-Hydroxyprogesterone 12-18 proopiomelanocortin Homo sapiens 69-73 9888582-2 1998 Rodent and porcine P450c17 also catalyze 17,20 lyase activity with delta4 substrates, converting 17OH-progesterone to delta4 androstenedione, but human P450c17 catalyzes this reaction very inefficiently, so that virtually all human C19 sex steroids are made via 17OH pregnenolone and DHEA. 17-alpha-Hydroxyprogesterone 97-114 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 152-159 9579234-9 1998 The 21-hydroxylase gene (CYP21) was examined for major deletions and for three common point mutations in 31 of the patients (14 with exaggerated 17-OHP response). 17-alpha-Hydroxyprogesterone 145-151 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 25-30 9593605-1 1998 STUDY OBJECTIVE: To determine whether human chorionic gonadotropin (hCG) stimulation elicits an exaggerated 17-hydroxyprogesterone (17-OHP) response in patients with functional ovarian hyperandrogenism. 17-alpha-Hydroxyprogesterone 108-130 hypertrichosis 2 (generalised, congenital) Homo sapiens 68-71 9593605-1 1998 STUDY OBJECTIVE: To determine whether human chorionic gonadotropin (hCG) stimulation elicits an exaggerated 17-hydroxyprogesterone (17-OHP) response in patients with functional ovarian hyperandrogenism. 17-alpha-Hydroxyprogesterone 132-138 hypertrichosis 2 (generalised, congenital) Homo sapiens 68-71 9593605-9 1998 After hCG stimulation, 17-hydroxyprogesterone concentrations significantly increased in the patients and were unchanged in the healthy controls. 17-alpha-Hydroxyprogesterone 23-45 hypertrichosis 2 (generalised, congenital) Homo sapiens 6-9 9593605-10 1998 CONCLUSION: hCG stimulation elicited greater 17-hydroxyprogesterone responses in adolescent girls with functional ovarian hyperandrogenism compared with healthy controls. 17-alpha-Hydroxyprogesterone 45-67 hypertrichosis 2 (generalised, congenital) Homo sapiens 12-15 9497336-1 1998 Three mutants (deletion of E196, G291S, and R483P) of steroid 21-hydroxylase (P450c21) from patients with inherited congenital adrenal hyperplasia had reduced activity toward progesterone and 17-hydroxyprogesterone after transient expression in cultured mammalian cells. 17-alpha-Hydroxyprogesterone 192-214 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 54-76 9539304-21 1998 A similar significant (P < 0.01), though not abnormal, 17-hydroxyprogesterone response to ACTH was found in both groups. 17-alpha-Hydroxyprogesterone 58-80 proopiomelanocortin Homo sapiens 93-97 9460762-5 1998 By using the pulse-chase technique, TTN was found to stimulate the conversion of [3H]pregnenolone into various steroids, including 17-hydroxypregnenolone, 5 alpha-dihydrotestosterone and 17-hydroxyprogesterone, in a dose-dependent manner. 17-alpha-Hydroxyprogesterone 187-209 titin Homo sapiens 36-39 9666866-6 1998 Molecular analysis of the CYP21B gene showed that in four out of the 10 tested patients with an exaggerated 17-OHP response there were heterozygous point mutations of the CYP21B gene. 17-alpha-Hydroxyprogesterone 108-114 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 26-32 9666866-6 1998 Molecular analysis of the CYP21B gene showed that in four out of the 10 tested patients with an exaggerated 17-OHP response there were heterozygous point mutations of the CYP21B gene. 17-alpha-Hydroxyprogesterone 108-114 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 171-177 9610421-3 1998 Using the ACTH-stimulated 17-OHP values at 60 minutes (17-OHP60) the study population was divided into four groups (A, B, C and D). 17-alpha-Hydroxyprogesterone 26-32 proopiomelanocortin Homo sapiens 10-14 9142140-14 1997 Combined exposure to CsA and DES enhanced the stimulatory effect of hCG on the accumulation of 17-OH-P in the media. 17-alpha-Hydroxyprogesterone 95-102 hypertrichosis 2 (generalised, congenital) Homo sapiens 68-71 9506857-6 1998 In particular, 9/35 patients with adrenal incidentaloma had markedly depressed BGP levels (<2.0 ng/ml; mean 0.8+/-0.1 ng/ml): all patients of this subgroup showed an exaggerated 17-hydroxyprogesterone increase after ACTH administration. 17-alpha-Hydroxyprogesterone 181-203 bone gamma-carboxyglutamate protein Homo sapiens 79-82 9437235-6 1997 ACTH-stimulated 17-OHP levels > 30 nmol/l were considered as the criteria of 21-OH deficiency. 17-alpha-Hydroxyprogesterone 16-22 proopiomelanocortin Homo sapiens 0-4 9437235-9 1997 ACTH-stimulated 17-OHP (P < 0.05) and 11-DOC (P < 0.0005) levels were found to be significantly higher in patients with PCOS than in controls. 17-alpha-Hydroxyprogesterone 16-22 proopiomelanocortin Homo sapiens 0-4 9281894-6 1997 EGF has also got a suppressive effect on 17 a-hydroxylase enzyme; a key enzyme which is necessary for the hydroxylation of pregnenolone and progesterone in the ovary Hydroxy pregnenolone is a precursor of androstendione, while 17 a-hydroxyprogesterone is a precursor of testosterone. 17-alpha-Hydroxyprogesterone 227-251 epidermal growth factor Homo sapiens 0-3 9169115-5 1997 Both human and salmon recombinant IGF-I inhibited the basal and GTH II-stimulated T and 17OH-P production by theca-interstitial layers throughout the preovulatory period. 17-alpha-Hydroxyprogesterone 88-94 insulin like growth factor 1 Homo sapiens 34-39 9150702-1 1997 OBJECTIVE: To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS). 17-alpha-Hydroxyprogesterone 131-153 insulin Homo sapiens 37-44 9150706-3 1997 Component CYP17 activities, i.e. simultaneously catalyzed productive androgen formation and abortive 17 alpha-hydroxyprogesterone release, and their ratio (processivity), were compared with CYP17 levels and testosterone secretion rates. 17-alpha-Hydroxyprogesterone 101-129 cytochrome P450, family 17, subfamily a, polypeptide 1 Rattus norvegicus 10-15 9150702-1 1997 OBJECTIVE: To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS). 17-alpha-Hydroxyprogesterone 155-161 gonadotropin releasing hormone 1 Homo sapiens 191-221 9150702-1 1997 OBJECTIVE: To determine whether hyperinsulinism affects cytochrome P450c17 alpha activity by investigating the correlation between 17-hydroxyprogesterone (17-OHP) hyper-responsiveness to the gonadotropin-releasing hormone (GnRH) agonist, buserelin, and the insulin response to oral glucose in polycystic ovary syndrome (PCOS). 17-alpha-Hydroxyprogesterone 155-161 insulin Homo sapiens 37-44 9150702-3 1997 We investigated the correlation between the 17-OHP response to buserelin testing and the insulin response to oral glucose in PCOS. 17-alpha-Hydroxyprogesterone 44-50 insulin Homo sapiens 89-96 9471921-14 1997 The serum concentrations of estrone (p < 0.01), estradiol, progesterone, 17-hydroxyprogesterone were significantly decreased in women chronically exposed to CS2 (p < 0.001). 17-alpha-Hydroxyprogesterone 76-98 chorionic somatomammotropin hormone 2 Homo sapiens 160-163 9024240-2 1997 We have hypothesized that heterozygosity for CYP21 mutations in women increases their risk of developing clinically evident hyperandrogenism, and that this risk is related to the severity of the mutation of CYP21 and/or the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 224-246 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 45-50 9024240-2 1997 We have hypothesized that heterozygosity for CYP21 mutations in women increases their risk of developing clinically evident hyperandrogenism, and that this risk is related to the severity of the mutation of CYP21 and/or the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 248-254 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 45-50 9024240-2 1997 We have hypothesized that heterozygosity for CYP21 mutations in women increases their risk of developing clinically evident hyperandrogenism, and that this risk is related to the severity of the mutation of CYP21 and/or the 17-hydroxyprogesterone (17-OHP) response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 248-254 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 207-212 9211124-0 1997 CYP17 gene analysis in hyperandrogenised women with and without exaggerated 17-hydroxyprogesterone response to ovarian stimulation. 17-alpha-Hydroxyprogesterone 76-98 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-5 9686000-0 1997 [Pre-toxic adrenocortical adenoma ("pre-Cushing syndrome"): role of 17-hydroxyprogesterone dosage under ACTH analog stimulation. 17-alpha-Hydroxyprogesterone 68-90 proopiomelanocortin Homo sapiens 104-108 9686000-4 1997 Basal ACTH and dehydroepiandrosterone sulfate levels were decreased and the 17-hydroxyprogesterone (17OHP) response under ACTH stimulation (tetracosactide) was increased. 17-alpha-Hydroxyprogesterone 76-98 proopiomelanocortin Homo sapiens 122-126 9686000-4 1997 Basal ACTH and dehydroepiandrosterone sulfate levels were decreased and the 17-hydroxyprogesterone (17OHP) response under ACTH stimulation (tetracosactide) was increased. 17-alpha-Hydroxyprogesterone 100-105 proopiomelanocortin Homo sapiens 122-126 9286728-3 1997 RESULTS: Women with POF showed statistically significantly lower concentrations of 17-OHP, A, T (p < 0.001) and a reduced bone density (p < 0.001) compared to fertile controls. 17-alpha-Hydroxyprogesterone 83-89 POF1B actin binding protein Homo sapiens 20-23 9167966-27 1997 Post-ACTH 17-OH progesterone levels were elevated in 52% (62/118 patients) of non-functioning adenomas and in 2 of 4 carcinomas. 17-alpha-Hydroxyprogesterone 10-28 proopiomelanocortin Homo sapiens 5-9 8977402-6 1997 Both rec preparations of 20 alpha HSD demonstrated a single polypeptide chain of 37 kDa with similar K(m) values for 20 alpha-hydroxyprogesterone and NADP, although the corresponding maximum velocity values were slightly lower for the rec 20 alpha HSD expressed in the insect cells. 17-alpha-Hydroxyprogesterone 120-145 aldo-keto reductase family 1, member C3 Rattus norvegicus 25-37 8977402-7 1997 The rec 20 alpha-HSD showed preference for progesterone/20 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 59-84 aldo-keto reductase family 1, member C3 Rattus norvegicus 8-20 9029719-11 1997 The dehydrogenase activity of 11 beta-HSD2 was inhibited 11 alpha-hydroxyprogesterone = 11 beta-hydroxyprogesterone > glycyrrhetinic acid > carbenoxolone = progesterone. 17-alpha-Hydroxyprogesterone 60-85 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 4-42 9029719-11 1997 The dehydrogenase activity of 11 beta-HSD2 was inhibited 11 alpha-hydroxyprogesterone = 11 beta-hydroxyprogesterone > glycyrrhetinic acid > carbenoxolone = progesterone. 17-alpha-Hydroxyprogesterone 60-85 hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens 30-37 9061508-0 1996 17-Hydroxyprogesterone response to ACTH in bilateral and monolateral adrenal incidentalomas. 17-alpha-Hydroxyprogesterone 0-22 proopiomelanocortin Homo sapiens 35-39 9441542-7 1997 Suitable in this case, are the 17-Hydroxyprogesterone derivatives, because the 19-Nortestosterone derivatives produce a negative influence on the Lipid metabolism due to their partial androgenic effect and in addition, antagonise the hepatocellular estrogen effect (IGF1-reduction and SHBG-increase), which may indirectly offer protection for the breast. 17-alpha-Hydroxyprogesterone 31-53 insulin like growth factor 1 Homo sapiens 266-270 9441542-7 1997 Suitable in this case, are the 17-Hydroxyprogesterone derivatives, because the 19-Nortestosterone derivatives produce a negative influence on the Lipid metabolism due to their partial androgenic effect and in addition, antagonise the hepatocellular estrogen effect (IGF1-reduction and SHBG-increase), which may indirectly offer protection for the breast. 17-alpha-Hydroxyprogesterone 31-53 sex hormone binding globulin Homo sapiens 285-289 9061508-5 1996 After ACTH, 17-OHP levels significantly (p < 0.05) increased in C, in M and B incidentalomas. 17-alpha-Hydroxyprogesterone 12-18 proopiomelanocortin Homo sapiens 6-10 9061508-7 1996 Individual data indicated that while 17-OHP response to ACTH in C never reached 5 ng/ml (cut-off for normal response), 16 out of 27 patients with incidentalomas (59.2%) exceeded this value. 17-alpha-Hydroxyprogesterone 37-43 proopiomelanocortin Homo sapiens 56-60 8923867-8 1996 Peak 17-OHP levels after hCG challenge and GnRH agonist stimulation were highly correlated (r = 0.82; P < 0.001) in the subjects receiving both stimuli. 17-alpha-Hydroxyprogesterone 5-11 chorionic gonadotropin subunit beta 5 Homo sapiens 25-28 8937587-3 1996 In the fibroblasts, either estradiol or progestogens (progesterone, medroxy progesterone acetate or 17 alpha-hydroxyprogesterone) induced expressions of PAI-1 and its mRNA, and their combination further increased their expression by approximately twofold. 17-alpha-Hydroxyprogesterone 100-128 serpin family E member 1 Homo sapiens 153-158 8969926-0 1996 The use of electrochemistry for the synthesis of 17 alpha-hydroxyprogesterone by a fusion protein containing P450c17. 17-alpha-Hydroxyprogesterone 49-77 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 109-116 8923867-11 1996 Our results suggest that exaggerated 17-OHP responses to GnRH agonist stimulation in hyperandrogenic women are not mediated by the known hyperresponsiveness of LH in these patients, but are due to increased ovarian androgen sensitivity to LH stimulation. 17-alpha-Hydroxyprogesterone 37-43 gonadotropin releasing hormone 1 Homo sapiens 57-61 9011227-7 1996 Purified cytochrome P-450c21 migrates as a single 54 kD band on polyacrylamide gel and exhibits type I spectral changes during interaction with progesterone and 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 161-189 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 9-28 8923867-0 1996 Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. 17-alpha-Hydroxyprogesterone 8-30 gonadotropin releasing hormone 1 Homo sapiens 54-84 8923867-0 1996 Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. 17-alpha-Hydroxyprogesterone 8-30 gonadotropin releasing hormone 1 Homo sapiens 86-90 8923867-1 1996 Women with polycystic ovary syndrome (PCOS: hyperandrogenism and oligomenorrhea) have been shown to have exaggerated ovarian 17-hydroxyprogesterone (17-OHP) responses after GnRH agonist stimulation, suggestive of disordered ovarian cytochrome P450c17 alpha activity. 17-alpha-Hydroxyprogesterone 149-155 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 243-250 8751729-7 1996 MAIN OUTCOME MEASURES: Basal E2 and androgen levels as well as dexamethasone-suppressed, ACTH-stimulated 17 alpha-hydroxyprogesterone, 17 alpha-hydroxypregnenolone, and androgen levels before and after ovarian suppression. 17-alpha-Hydroxyprogesterone 105-133 proopiomelanocortin Homo sapiens 89-93 9009232-2 1996 In Ishikawa cells, either estradiol or progestins (progesterone, medroxyprogesterone acetate, or 17 alpha-hydroxyprogesterone alone) induced the expression of PAI-1 and its mRNA, and those expressions were increased approximately two-fold by both estradiol and progestin administered together. 17-alpha-Hydroxyprogesterone 97-125 serpin family E member 1 Homo sapiens 159-164 8806785-3 1996 When NADPH is used as electron donor with a reconstituted system composed of d-OR and P450c17, the addition of t-OR, flavodoxin, or cytochrome c inhibited the rate of formation of 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 183-208 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 86-93 8806785-3 1996 When NADPH is used as electron donor with a reconstituted system composed of d-OR and P450c17, the addition of t-OR, flavodoxin, or cytochrome c inhibited the rate of formation of 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 183-208 cytochrome c, somatic Homo sapiens 132-144 8701783-4 1996 Growth hormone was effective on estradiol, progesterone and 17-OHP at 1 microgram/ml, enhancing estradiol production (1.3 +/- 0.2-fold the control value; p < 0.05 vs. control), progesterone production (2.5 +/- 1.0-fold the control value; p < 0.05 vs. control), and 17-OHP (1.4 +/- 0.2-fold the control value; p < 0.05 vs. control). 17-alpha-Hydroxyprogesterone 60-66 growth hormone 1 Homo sapiens 0-14 8768833-10 1996 The pattern of response of the 17-OH-progesterone/cortisol ratio to ACTH stimulation in patients with 21-OH autoantibodies was not consistent with the autoantibodies inhibiting the 21-OH activity. 17-alpha-Hydroxyprogesterone 31-49 proopiomelanocortin Homo sapiens 68-72 8701783-4 1996 Growth hormone was effective on estradiol, progesterone and 17-OHP at 1 microgram/ml, enhancing estradiol production (1.3 +/- 0.2-fold the control value; p < 0.05 vs. control), progesterone production (2.5 +/- 1.0-fold the control value; p < 0.05 vs. control), and 17-OHP (1.4 +/- 0.2-fold the control value; p < 0.05 vs. control). 17-alpha-Hydroxyprogesterone 271-277 growth hormone 1 Homo sapiens 0-14 8701783-8 1996 These results indicate a direct effect of growth hormone on steroidogenesis by increasing P450c17 mRNA accumulation and progesterone, 17-OHP and estradiol production. 17-alpha-Hydroxyprogesterone 134-140 growth hormone 1 Homo sapiens 42-56 8772544-8 1996 ACTH-stimulated serum 17-OHPREG and, to a lesser extent, 17-OHP were significantly higher during insulin than during saline infusion (peaks, 60.6 +/- 9.0 vs. 40.7 +/- 7.9 and 7.7 +/- 7.7 vs. 6.6 +/- 0.6 nmol/L; P < 0.005 and P < 0.01, respectively). 17-alpha-Hydroxyprogesterone 22-28 proopiomelanocortin Homo sapiens 0-4 8772544-8 1996 ACTH-stimulated serum 17-OHPREG and, to a lesser extent, 17-OHP were significantly higher during insulin than during saline infusion (peaks, 60.6 +/- 9.0 vs. 40.7 +/- 7.9 and 7.7 +/- 7.7 vs. 6.6 +/- 0.6 nmol/L; P < 0.005 and P < 0.01, respectively). 17-alpha-Hydroxyprogesterone 22-28 insulin Homo sapiens 97-104 8772544-11 1996 ACTH-stimulated 17-OHPREG/DHEA and 17-OHP/A molar ratios, indexes of apparent 17,20-lyase activity, were significantly higher during the clamp studies than during saline infusion (by ANOVA, F = 12.8; P < 0.001 and F = 6.7; P < 0.005, respectively), suggesting an impaired enzyme activity. 17-alpha-Hydroxyprogesterone 16-22 proopiomelanocortin Homo sapiens 0-4 7492620-7 1995 These observations suggest that 20 beta-hydroxyprogesterone binds to the cytochrome P-450c21 active center in a very similar manner as 17 alpha-hydroxyprogesterone does and, therefore, may be a metabolizable substrate. 17-alpha-Hydroxyprogesterone 135-163 steroid 21-hydroxylase Bos taurus 73-92 7662675-6 1995 We analyzed the effects of pH and the amount of NADPH-cytochrome P-450 reductase on the successive reaction and proved that the reaction was regulated by the rate of electron transfer for the conversion of the bound 17 alpha-hydroxyprogesterone to androstenedione. 17-alpha-Hydroxyprogesterone 219-244 cytochrome p450 oxidoreductase Homo sapiens 48-80 7581961-1 1995 Exaggerated adrenal response (ExAR), i.e. hypersecretion of both 17-hydroxypregnenolone (170HPreg) and 17-hydroxyprogesterone(17OHP) in response to adrenocorticotropic hormone (ACTH) stimulation, is frequently found in women with polycystic ovary (PCO) syndrome who had precocious adrenarche. 17-alpha-Hydroxyprogesterone 103-125 proopiomelanocortin Homo sapiens 148-175 7581961-1 1995 Exaggerated adrenal response (ExAR), i.e. hypersecretion of both 17-hydroxypregnenolone (170HPreg) and 17-hydroxyprogesterone(17OHP) in response to adrenocorticotropic hormone (ACTH) stimulation, is frequently found in women with polycystic ovary (PCO) syndrome who had precocious adrenarche. 17-alpha-Hydroxyprogesterone 126-131 proopiomelanocortin Homo sapiens 148-175 7608617-4 1995 Plasma PAF-AH activity in female adult rats treated with either progesterone or 17 alpha-hydroxyprogesterone (50mg/kg, 3 days) did not change significantly. 17-alpha-Hydroxyprogesterone 83-108 phospholipase A2 group VII Rattus norvegicus 7-13 8948449-14 1995 17 alpha-Hydroxyprogesterone was a poor substrate for the human CYP17; although it was converted into androstenedione in the presence of cytochrome b5 its K(m) was 5 times higher and Vmax. 17-alpha-Hydroxyprogesterone 0-28 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-69 8948449-14 1995 17 alpha-Hydroxyprogesterone was a poor substrate for the human CYP17; although it was converted into androstenedione in the presence of cytochrome b5 its K(m) was 5 times higher and Vmax. 17-alpha-Hydroxyprogesterone 0-28 cytochrome b5 type A Homo sapiens 137-150 7629236-9 1995 In patients with increased hCG values (i.e. > 5 IU/L), the mean plasma P, 17-OHP, A, 17-OH delta 5-P, DHEA, T, and E2 levels were higher (P < 0.01 at least) than those in patients whose hCG values were normalized or in controls. 17-alpha-Hydroxyprogesterone 77-83 hypertrichosis 2 (generalised, congenital) Homo sapiens 27-30 7750587-9 1995 Important findings in the oligoamenorrheic athletes were a significantly lower ratio between the ACTH-induced increments of DHEA and 17-OHP and an increased ratio between basal A and DHEAS. 17-alpha-Hydroxyprogesterone 133-139 proopiomelanocortin Homo sapiens 97-101 7621565-1 1995 OBJECTIVE: A previously published study has identified that anovulatory women with PCOS have an increased response of 17 alpha-hydroxyprogesterone (17OHP) and androstenedione to a GnRH analogue suggesting dysregulation of cytochrome P450c17 alpha. 17-alpha-Hydroxyprogesterone 118-146 gonadotropin releasing hormone 1 Homo sapiens 180-184 7621565-1 1995 OBJECTIVE: A previously published study has identified that anovulatory women with PCOS have an increased response of 17 alpha-hydroxyprogesterone (17OHP) and androstenedione to a GnRH analogue suggesting dysregulation of cytochrome P450c17 alpha. 17-alpha-Hydroxyprogesterone 118-146 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 222-246 7621565-1 1995 OBJECTIVE: A previously published study has identified that anovulatory women with PCOS have an increased response of 17 alpha-hydroxyprogesterone (17OHP) and androstenedione to a GnRH analogue suggesting dysregulation of cytochrome P450c17 alpha. 17-alpha-Hydroxyprogesterone 148-153 gonadotropin releasing hormone 1 Homo sapiens 180-184 7621565-1 1995 OBJECTIVE: A previously published study has identified that anovulatory women with PCOS have an increased response of 17 alpha-hydroxyprogesterone (17OHP) and androstenedione to a GnRH analogue suggesting dysregulation of cytochrome P450c17 alpha. 17-alpha-Hydroxyprogesterone 148-153 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 222-246 7621565-14 1995 By contrast, the responses of both androstenedione and 17OHP to 250 micrograms synthetic ACTH were similar in PCO women to those in controls. 17-alpha-Hydroxyprogesterone 55-60 proopiomelanocortin Homo sapiens 89-93 7758232-0 1995 Increased 17 alpha-hydroxyprogesterone response to ACTH in silent adrenal adenoma: cause or effect? 17-alpha-Hydroxyprogesterone 10-38 proopiomelanocortin Homo sapiens 51-55 7890056-9 1995 RESULTS: In the high DHEAS group the maximum increases in T, A, 17-OHP, and DHEAS in response to ACTH were significantly higher than in normal DHEAS PCOS women and in normal women. 17-alpha-Hydroxyprogesterone 64-70 sulfotransferase family 2A member 1 Homo sapiens 21-26 7890056-9 1995 RESULTS: In the high DHEAS group the maximum increases in T, A, 17-OHP, and DHEAS in response to ACTH were significantly higher than in normal DHEAS PCOS women and in normal women. 17-alpha-Hydroxyprogesterone 64-70 proopiomelanocortin Homo sapiens 97-101 7893148-7 1995 In particular, they indicate that in human testes which contains a high b5/P450 ratio, 17 alpha-hydroxyprogesterone can serve as an intermediate in testosterone production, rather than being a dead-end product, or stated another way, because of the relatively high concentration of cytochrome b5 in the human testis, both the delta 4 and the delta 5 steroidogenic pathways can lead to testosterone production. 17-alpha-Hydroxyprogesterone 87-115 cytochrome b5 type A Homo sapiens 282-295 7892885-1 1995 OBJECTIVE: Our purpose was to establish the incidence of point mutations of the 21-hydroxylase gene (CYP21) in hyperandrogenic women with and without a 17-hydroxyprogesterone response to corticotropin stimulation above normal but below those levels associated with nonclassic adrenal hyperplasia. 17-alpha-Hydroxyprogesterone 152-174 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 101-106 7892885-8 1995 CONCLUSIONS: These findings suggest that the majority of hyperandrogenic women with an exaggerated 17-hydroxyprogesterone response to corticotropin stimulation are heterozygotes (carriers) for inherited defects of CYP21. 17-alpha-Hydroxyprogesterone 99-121 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 214-219 7588393-3 1995 P450c21 can 21-hydroxylate 17 alpha-hydroxyprogesterone to yield cortisol but also converts progesterone to corticosterone. 17-alpha-Hydroxyprogesterone 27-55 steroid 21-hydroxylase Ovis aries 0-7 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 99-121 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-62 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 99-121 gonadotropin releasing hormone 1 Homo sapiens 145-176 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 99-121 gonadotropin releasing hormone 1 Homo sapiens 178-182 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 123-129 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-62 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 123-129 gonadotropin releasing hormone 1 Homo sapiens 145-176 7782424-2 1995 It has been proposed that a dysfunction of cytochrome P-450c17 alpha in PCOS leads to an increased 17-hydroxyprogesterone (17-OHP) response to a gonadotrophin-releasing hormone (GnRH) agonist-induced gonadotrophin rise. 17-alpha-Hydroxyprogesterone 123-129 gonadotropin releasing hormone 1 Homo sapiens 178-182 7782424-11 1995 Exaggerated 17-OHP and oestradiol responses to GnRH agonist were found in 89% of patients with clinically diagnosed PCOS. 17-alpha-Hydroxyprogesterone 12-18 gonadotropin releasing hormone 1 Homo sapiens 47-51 8203904-6 1994 Further, dehydroepiandrosterone is slowly metabolized to a number of additional more polar metabolites while 17 alpha-hydroxy-progesterone is slowly converted to dihydroxy-progesterone metabolites as well as a small amount of androstenedione in a reaction not influenced by cytochrome b5. 17-alpha-Hydroxyprogesterone 109-138 cytochrome b5 type A Rattus norvegicus 274-287 7714138-10 1994 Similarly, naltrexone abolished the difference between normoinsulinaemic and hyperinsulinaemic patients regarding androstenedione and 17-OHP response to ACTH. 17-alpha-Hydroxyprogesterone 134-140 proopiomelanocortin Homo sapiens 153-157 21153151-10 1995 Treatment of PCOS theca cells with EGF, FGF, TGFbeta and TPA resulted in the inhibition of forskolin-stimulated 17alpha-hydroxyprogesterone production. 17-alpha-Hydroxyprogesterone 112-139 epidermal growth factor Homo sapiens 35-38 21153151-10 1995 Treatment of PCOS theca cells with EGF, FGF, TGFbeta and TPA resulted in the inhibition of forskolin-stimulated 17alpha-hydroxyprogesterone production. 17-alpha-Hydroxyprogesterone 112-139 transforming growth factor beta 1 Homo sapiens 45-52 7989476-0 1994 Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism. 17-alpha-Hydroxyprogesterone 25-47 gonadotropin releasing hormone 1 Homo sapiens 70-100 8027214-2 1994 Treatment of thecal cells with epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF beta), and tetradecanoyl phorbol acetate (TPA) resulted in the inhibition of forskolin- and dibutyryl cAMP-stimulated 17 alpha-hydroxylase activity and 17 alpha-hydroxyprogesterone and dehydroepiandrosterone production. 17-alpha-Hydroxyprogesterone 286-311 transforming growth factor beta 1 Homo sapiens 94-125 8027214-2 1994 Treatment of thecal cells with epidermal growth factor (EGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF beta), and tetradecanoyl phorbol acetate (TPA) resulted in the inhibition of forskolin- and dibutyryl cAMP-stimulated 17 alpha-hydroxylase activity and 17 alpha-hydroxyprogesterone and dehydroepiandrosterone production. 17-alpha-Hydroxyprogesterone 286-311 transforming growth factor beta 1 Homo sapiens 127-135 8081391-4 1994 Steroid 21-hydroxylase (P450c21) is a microsomal enzyme expressed in the adrenal gland that catalyzes conversion of 17-hydroxyprogesterone and progesterone to 11-deoxycortisol and deoxycorticosterone respectively. 17-alpha-Hydroxyprogesterone 116-138 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 0-22 8018399-5 1994 A significant inverse association was found between CA125 and progesterone levels, and CA125 and 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 97-119 mucin 16, cell surface associated Homo sapiens 87-92 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 335-363 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-50 8290386-5 1994 In response to ACTH, a decreased 17-alpha hydroxyprogesterone (17-OHP) accumulation and an augmented A/17-OHP ratio were observed in the antiandrogen group (P < 0.05 for both), suggesting the partial removal of the 17,20 lyase block which was distinctive of the untreated controls, while no significant difference was found for other steroids. 17-alpha-Hydroxyprogesterone 33-61 proopiomelanocortin Homo sapiens 15-19 8290386-5 1994 In response to ACTH, a decreased 17-alpha hydroxyprogesterone (17-OHP) accumulation and an augmented A/17-OHP ratio were observed in the antiandrogen group (P < 0.05 for both), suggesting the partial removal of the 17,20 lyase block which was distinctive of the untreated controls, while no significant difference was found for other steroids. 17-alpha-Hydroxyprogesterone 63-69 proopiomelanocortin Homo sapiens 15-19 8290386-5 1994 In response to ACTH, a decreased 17-alpha hydroxyprogesterone (17-OHP) accumulation and an augmented A/17-OHP ratio were observed in the antiandrogen group (P < 0.05 for both), suggesting the partial removal of the 17,20 lyase block which was distinctive of the untreated controls, while no significant difference was found for other steroids. 17-alpha-Hydroxyprogesterone 103-109 proopiomelanocortin Homo sapiens 15-19 8404664-6 1993 ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate. 17-alpha-Hydroxyprogesterone 130-159 natriuretic peptide type A Mus musculus 0-3 8404664-6 1993 ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate. 17-alpha-Hydroxyprogesterone 130-159 natriuretic peptide type B Mus musculus 5-8 8404664-6 1993 ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate. 17-alpha-Hydroxyprogesterone 130-159 natriuretic peptide type C Mus musculus 14-17 7997146-7 1994 The concentrations of estrone (p < 0.01), estradiol, progesterone, 17-hydroxy-progesterone, testosterone and dehydroepiandrosterone sulphate (DHAS) were significantly decreased in women chronically exposed to CS2 (p < 0.001). 17-alpha-Hydroxyprogesterone 70-93 chorionic somatomammotropin hormone 2 Homo sapiens 212-215 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 335-363 cytochrome p450 oxidoreductase Rattus norvegicus 104-135 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 335-363 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 43-47 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 335-363 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 121-125 8396144-6 1993 The expected enzymatic activities of human P450c17 were reconstituted by addition of purified rat liver NADPH-cytochrome P450 reductase, giving turnover numbers of 8.0 nmol/min/nmol P450 for pregnenolone, 6.5 nmol/min/nmol P450 for progesterone, 0.06 nmol/min/nmol P450 for 17 alpha-hydroxypregnenolone, and no detectable activity for 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 335-363 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 121-125 8323171-1 1993 We have found that women with typical polycystic ovary syndrome have supranormal plasma 17-hydroxyprogesterone responses to a 100-micrograms test dose of the gonadotropin-releasing hormone agonist nafarelin without evidence of hindered estrogen secretion. 17-alpha-Hydroxyprogesterone 88-110 gonadotropin releasing hormone 1 Homo sapiens 158-188 8412766-4 1993 Levels of 17-OHP increased after CRH administration, and the magnitude of increase was similar in all subjects. 17-alpha-Hydroxyprogesterone 10-16 corticotropin releasing hormone Homo sapiens 33-36 8323292-3 1993 When intact E. coli cells were used for analysis, the truncated P450c17 showed the typical cytochrome P450 CO-difference spectrum and type I substrate binding spectra for pregnenolone, 17 alpha-hydroxypregnenolone, progesterone, and 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 236-261 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 64-71 8431420-6 1993 Further, the enzyme purified to homogeneity by following activity with 17-hydroxyprogesterone as a substrate was shown to reduce glucose, glyceraldehyde, and benzaldehyde (all classic aldose reductase substrates). 17-alpha-Hydroxyprogesterone 71-93 aldose reductase Bos taurus 184-200 8481471-8 1993 Culture of the granulosa cells with FSH plus TGF alpha or with FSH plus EGF resulted in significantly elevated progesterone and 20 alpha-hydroxyprogesterone levels. 17-alpha-Hydroxyprogesterone 131-156 transforming growth factor alpha Rattus norvegicus 45-54 8481471-8 1993 Culture of the granulosa cells with FSH plus TGF alpha or with FSH plus EGF resulted in significantly elevated progesterone and 20 alpha-hydroxyprogesterone levels. 17-alpha-Hydroxyprogesterone 131-156 epidermal growth factor like 1 Rattus norvegicus 72-75 1410766-3 1992 Although EGF alone did not affect in vitro testicular steroidogenesis, it significantly potentiated the HCG-induced elevation of the accumulation of testosterone and 17-hydroxyprogesterone in the media. 17-alpha-Hydroxyprogesterone 166-188 pro-epidermal growth factor Mesocricetus auratus 9-12 1319000-2 1992 We have found that women with the polycystic ovary syndrome have supranormal plasma 17-hydroxyprogesterone responses to the gonadotropin-releasing hormone agonist nafarelin. 17-alpha-Hydroxyprogesterone 84-106 gonadotropin releasing hormone 1 Homo sapiens 124-154 1323921-3 1992 An elevated response of cortisol precursors like 17 alpha-hydroxyprogesterone (17-OHP) to ACTH stimulation is a valuable diagnostic criteria. 17-alpha-Hydroxyprogesterone 79-85 proopiomelanocortin Homo sapiens 90-94 1323921-8 1992 Six patients demonstrated an increase in both the 17 alpha-hydroxyprogesterone levels and the 17 alpha-hydroxyprogesterone/cortisol ratio on ACTH stimulation, almost twice that of the mean +/- 2SD in the control group and ten times that in one patient. 17-alpha-Hydroxyprogesterone 50-78 proopiomelanocortin Homo sapiens 141-145 1323921-8 1992 Six patients demonstrated an increase in both the 17 alpha-hydroxyprogesterone levels and the 17 alpha-hydroxyprogesterone/cortisol ratio on ACTH stimulation, almost twice that of the mean +/- 2SD in the control group and ten times that in one patient. 17-alpha-Hydroxyprogesterone 94-122 proopiomelanocortin Homo sapiens 141-145 1354409-4 1992 Moreover, patients carrying a duplicated C4B (as well as those having the B14 antigen) showed higher 17-hydroxyprogesterone levels after ACTH stimulation. 17-alpha-Hydroxyprogesterone 101-123 complement C4B (Chido blood group) Homo sapiens 41-44 1354409-4 1992 Moreover, patients carrying a duplicated C4B (as well as those having the B14 antigen) showed higher 17-hydroxyprogesterone levels after ACTH stimulation. 17-alpha-Hydroxyprogesterone 101-123 NADH:ubiquinone oxidoreductase subunit A6 Homo sapiens 74-77 8447190-11 1993 The 17 alpha-hydroxyprogesterone area, on the contrary, was significantly higher during GH withdrawal (542 +/- 307 vs 235 +/- 190; M +/- SD; p < 0.05). 17-alpha-Hydroxyprogesterone 4-32 MSD Homo sapiens 131-139 8446108-2 1993 The steroidogenic enzyme 20 alpha HSD regulates the conversion of progesterone to 20 alpha-hydroxyprogesterone in many mammalian species. 17-alpha-Hydroxyprogesterone 85-110 prostaglandin-E(2) 9-reductase Oryctolagus cuniculus 25-37 8235158-10 1993 It is concluded that 3 beta HSD is frequent in hirsute women and that its diagnosis requires the determination of ACTH stimulated 17 hydroxypregnenolone values and 17 hydroxypregnenolone/17 hydroxyprogesterone ratio. 17-alpha-Hydroxyprogesterone 187-209 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 21-31 1337905-0 1992 Incidental adrenal nodules: association with exaggerated 17-hydroxyprogesterone response to adrenocorticotropic hormone. 17-alpha-Hydroxyprogesterone 57-79 proopiomelanocortin Homo sapiens 92-119 1337905-1 1992 The etiology of incidentally discovered, nonfunctional adrenal nodules was evaluated by using the 17-hydroxyprogesterone (17-OHP) response to synthetic adrenocorticotrophin (cosyntropin) (ACTH) administration. 17-alpha-Hydroxyprogesterone 98-120 proopiomelanocortin Homo sapiens 188-192 1337905-1 1992 The etiology of incidentally discovered, nonfunctional adrenal nodules was evaluated by using the 17-hydroxyprogesterone (17-OHP) response to synthetic adrenocorticotrophin (cosyntropin) (ACTH) administration. 17-alpha-Hydroxyprogesterone 122-128 proopiomelanocortin Homo sapiens 188-192 1337905-7 1992 After stimulation with ACTH, both 30 min and 60 min 17-OHP levels in patients with adrenal nodules (322 +/- 47 and 361 +/- 54 ng/dl, respectively) were significantly elevated over the responses seen with the controls (169 +/- 29 ng/dl at 30 min, p < 0.015, and 158 +/- 20 ng/dl at 60 min, p < 0.004). 17-alpha-Hydroxyprogesterone 52-58 proopiomelanocortin Homo sapiens 23-27 1431439-3 1992 2) In a tracer experiment, Gn-RHa inhibited PMSG-stimulated progesterone production by stimulating 20 alpha-hydroxyprogesterone production. 17-alpha-Hydroxyprogesterone 102-127 gonadotropin releasing hormone 1 Rattus norvegicus 27-33 1431439-5 1992 3) On 20 alpha-hydroxysteroid dehydrogenase activity, it appears that Gn-RHa accelerates the maximum velocity and decreases the affinity of the enzyme to 20 alpha-hydroxyprogesterone as the substrate. 17-alpha-Hydroxyprogesterone 157-182 gonadotropin releasing hormone 1 Rattus norvegicus 70-76 1333183-5 1992 Although, there was an age related decrease in the response of C19-steroids to ACTH, the response of pregnenolone and 17 alpha-hydroxyprogesterone to ACTH did not alter with age. 17-alpha-Hydroxyprogesterone 118-146 proopiomelanocortin Homo sapiens 150-154 1333183-6 1992 The preserved response of 17 alpha-hydroxyprogesterone to ACTH in post-menopausal women suggests that 17 alpha-hydroxyprogesterone production plays a role in the age independency of cortisol. 17-alpha-Hydroxyprogesterone 26-54 proopiomelanocortin Homo sapiens 58-62 1333183-6 1992 The preserved response of 17 alpha-hydroxyprogesterone to ACTH in post-menopausal women suggests that 17 alpha-hydroxyprogesterone production plays a role in the age independency of cortisol. 17-alpha-Hydroxyprogesterone 102-130 proopiomelanocortin Homo sapiens 58-62 1430842-6 1992 However, the binding properties of HIV+CBG were abnormal: the Ka"s for cortisol and 17 alpha hydroxyprogesterone binding were 50% below normal, while the number of binding sites was significantly higher. 17-alpha-Hydroxyprogesterone 84-112 serpin family A member 6 Homo sapiens 39-42 1320053-8 1992 The hCG-induced accumulation of 20 alpha-hydroxyprogesterone was also attenuated by simultaneous activin-A treatment compared to that in cells treated with hCG alone (P less than 0.01). 17-alpha-Hydroxyprogesterone 35-60 inhibin subunit beta E Homo sapiens 97-104 1323921-3 1992 An elevated response of cortisol precursors like 17 alpha-hydroxyprogesterone (17-OHP) to ACTH stimulation is a valuable diagnostic criteria. 17-alpha-Hydroxyprogesterone 49-77 proopiomelanocortin Homo sapiens 90-94 1314848-5 1992 After the therapy, no significant differences were detected in the responses of cortisol, dehydroepiandrosterone-sulfate, androstenedione, and 17-hydroxyprogesterone to ACTH 1-17, whereas an increased 11-deoxycortisol responsiveness to ACTH 1-17 was noted (P less than 0.005). 17-alpha-Hydroxyprogesterone 143-165 proopiomelanocortin Homo sapiens 169-173 1561629-19 1992 These data suggest that the decrease in serum testosterone following hCG challenge may be due to a decrease in the conversion of 17 alpha-hydroxyprogesterone to androstenedione. 17-alpha-Hydroxyprogesterone 129-157 chorionic gonadotropin subunit beta 5 Homo sapiens 69-72 1832519-4 1991 In response to gonadotropin-releasing hormone agonist, basal serum luteinizing hormone, follicle-stimulating hormone, estradiol, estrone, 17-hydroxyprogesterone, androstenedione, and testosterone in all three groups were suppressed to similar levels. 17-alpha-Hydroxyprogesterone 138-160 gonadotropin releasing hormone 1 Homo sapiens 15-45 1730815-7 1992 The insulin-induced change in this steroid ratio was due to a relative increase in precursor (17 alpha-hydroxyprogesterone) and decrease in product (androstenedione) responsiveness to ACTH. 17-alpha-Hydroxyprogesterone 94-122 insulin Homo sapiens 4-11 1309366-9 1992 There was a significant correlation (r = 0.70) between 17-OHP and the ACTH responses to oCRH. 17-alpha-Hydroxyprogesterone 55-61 proopiomelanocortin Homo sapiens 70-74 1309366-10 1992 The 17-OHP responses to oCRH were also correlated (r = 0.94) with the 17-OHP responses to the synthetic ACTH test. 17-alpha-Hydroxyprogesterone 4-10 proopiomelanocortin Homo sapiens 104-108 1309366-10 1992 The 17-OHP responses to oCRH were also correlated (r = 0.94) with the 17-OHP responses to the synthetic ACTH test. 17-alpha-Hydroxyprogesterone 70-76 proopiomelanocortin Homo sapiens 104-108 1309366-11 1992 We conclude that the release of endogenous ACTH by oCRH result in graded 17-OHP responses on 21-OH deficiency. 17-alpha-Hydroxyprogesterone 73-79 proopiomelanocortin Homo sapiens 43-47 1844874-5 1991 In the AH22/pAR gamma alpha cells, progesterone was first converted into 17 alpha-hydroxyprogesterone to the extent of 82% by the catalysis of P450c17. 17-alpha-Hydroxyprogesterone 73-101 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 143-150 1844874-6 1991 17 alpha-hydroxyprogesterone was further converted into 11-deoxycortisol by P450c21 to the extent of 60% of the added substrate. 17-alpha-Hydroxyprogesterone 0-28 steroid 21-hydroxylase Bos taurus 76-83 2004039-3 1991 The two most abundant potential substrates for follicular steroid 21-hydroxylase, progesterone (P) and 17-hydroxyprogesterone (17OHP), were converted respectively to 11-deoxycorticosterone (DOC) and 11-deoxycortisol with corresponding apparent specific activities of 308 and 24 pmol/mg protein/h and apparent Km values of 1.1 and 6.4 microM. 17-alpha-Hydroxyprogesterone 103-125 cytochrome P450 family 21 subfamily A member 1 Equus caballus 58-80 1955079-5 1991 The expressed protein was similar in size to 3 beta-HSD present in H540 Leydig tumor cell homogenate and human placental microsomal 3 beta-HSD, as detected by immunoblot analysis, and catalyzed the conversion of pregnenolone to progesterone, 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, and dehydroepiandrosterone to androstenedione. 17-alpha-Hydroxyprogesterone 274-302 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Rattus norvegicus 45-55 1955079-5 1991 The expressed protein was similar in size to 3 beta-HSD present in H540 Leydig tumor cell homogenate and human placental microsomal 3 beta-HSD, as detected by immunoblot analysis, and catalyzed the conversion of pregnenolone to progesterone, 17 alpha-hydroxypregnenolone to 17 alpha-hydroxyprogesterone, and dehydroepiandrosterone to androstenedione. 17-alpha-Hydroxyprogesterone 274-302 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Rattus norvegicus 132-142 1719019-9 1991 IGFBP-2 synthesis was increased two-fold above controls by 17-alpha-hydroxyprogesterone, and RU 486 alone and hydrocortisone were without effect. 17-alpha-Hydroxyprogesterone 59-87 insulin like growth factor binding protein 2 Homo sapiens 0-7 1952114-5 1991 17OHP rose with hCG alone, but not with hCG + Tx in both groups. 17-alpha-Hydroxyprogesterone 0-5 hypertrichosis 2 (generalised, congenital) Homo sapiens 16-19 1654730-15 1991 Moreover, the amplitude of the response of 17OHP and androstenedione to ACTH is predictable in relation to both circadian and dexamethasone-inhibited amounts (p less than 0.01). 17-alpha-Hydroxyprogesterone 43-48 proopiomelanocortin Homo sapiens 72-76 2004039-3 1991 The two most abundant potential substrates for follicular steroid 21-hydroxylase, progesterone (P) and 17-hydroxyprogesterone (17OHP), were converted respectively to 11-deoxycorticosterone (DOC) and 11-deoxycortisol with corresponding apparent specific activities of 308 and 24 pmol/mg protein/h and apparent Km values of 1.1 and 6.4 microM. 17-alpha-Hydroxyprogesterone 127-132 cytochrome P450 family 21 subfamily A member 1 Equus caballus 58-80 2120084-9 1990 Only cells pretreated in vivo with GnRH-a accumulated 20 alpha-hydroxyprogesterone in culture. 17-alpha-Hydroxyprogesterone 57-82 gonadotropin releasing hormone 1 Homo sapiens 35-39 2125425-9 1990 The Km values for 17 alpha-hydroxyprogesterone of P450c21 in the strains Y21 and Y21R, and of the fused enzymes in the strains Y21RF1 and Y21RF2 were 0.29, 0.30, 0.67, and 0.65 microM, respectively. 17-alpha-Hydroxyprogesterone 18-46 steroid 21-hydroxylase Bos taurus 50-57 2125425-12 1990 While the strain AH22/pAFR gamma 2 (YR21F2) produced about 3 X 10(4) molecules per cell of the reductase/P450c21 fused enzyme, the specific 21-hydroxylase activity of the fused enzyme toward 17 alpha-hydroxyprogesterone was extremely low, suggesting that the structure of the fused enzyme might not be suited for electron transfer in yeast microsomes. 17-alpha-Hydroxyprogesterone 194-219 steroid 21-hydroxylase Bos taurus 105-112 1964539-7 1990 A significant increase of serum hormone levels after ACTH administration could be observed for the following hormones: cortisol, 17 alpha-hydroxyprogesterone, 17 alpha-hydroxypregnenolone and dehydroepiandrosterone. 17-alpha-Hydroxyprogesterone 129-157 proopiomelanocortin Homo sapiens 53-57 2166094-2 1990 The diagnosis is made through the exaggerated response of 17 alpha-hydroxyprogesterone (17-OH) to adrenocorticotrophic hormone (ACTH). 17-alpha-Hydroxyprogesterone 58-86 proopiomelanocortin Homo sapiens 128-132 2167211-13 1990 Furthermore, IL-2 significantly inhibited the conversion of 20-OH-cholesterol, 22-OH-cholesterol, pregnenolone, progesterone, 17 alpha-hydroxypregnenolone, and 17 alpha-hydroxyprogesterone to testosterone but did not alter the conversion of dehydroepiandrosterone and androstenedione to testosterone. 17-alpha-Hydroxyprogesterone 160-188 interleukin 2 Homo sapiens 13-17 2137133-15 1990 The mean 17-HP level 30 min after ACTH administration (17-HP30) was significantly higher in hyperandrogenic women than in normal subjects whether analyzed in separate subgroups or together and was due to the higher basal 17-HP levels. 17-alpha-Hydroxyprogesterone 9-14 proopiomelanocortin Homo sapiens 34-38 2109690-4 1990 Under both culture conditions, human recombinant TNF (5 ng/ml) significantly increased the production of pregnenolone, progesterone, 20 alpha-dihydroprogesterone, and 17 alpha-hydroxyprogesterone by the follicles. 17-alpha-Hydroxyprogesterone 170-195 tumor necrosis factor Homo sapiens 49-52 2164496-2 1990 Late onset congenital adrenal hyperplasia (LOCAH) was detected in five (10.6%) on the basis of elevated basal and/or ACTH stimulated levels of 17 OHP. 17-alpha-Hydroxyprogesterone 143-149 proopiomelanocortin Homo sapiens 117-121 2137133-15 1990 The mean 17-HP level 30 min after ACTH administration (17-HP30) was significantly higher in hyperandrogenic women than in normal subjects whether analyzed in separate subgroups or together and was due to the higher basal 17-HP levels. 17-alpha-Hydroxyprogesterone 55-60 proopiomelanocortin Homo sapiens 34-38 2137133-17 1990 Alternatively, the net increment in 17-HP from 0-30 min after ACTH (delta 17-HP30) was not significantly higher in hyperandrogenic women than normal subjects and did not correlate with the basal levels of T, A, and P. Neither the basal level of 17-HP nor its response to ACTH correlated with circulating DHS levels. 17-alpha-Hydroxyprogesterone 36-41 proopiomelanocortin Homo sapiens 62-66 2137133-17 1990 Alternatively, the net increment in 17-HP from 0-30 min after ACTH (delta 17-HP30) was not significantly higher in hyperandrogenic women than normal subjects and did not correlate with the basal levels of T, A, and P. Neither the basal level of 17-HP nor its response to ACTH correlated with circulating DHS levels. 17-alpha-Hydroxyprogesterone 36-41 proopiomelanocortin Homo sapiens 271-275 2327831-1 1990 To determine the function of Leydig cells in patients with varicocele, hCG-stimulated levels of progesterone (Prog), 17 alpha-Hydroxy-4-pregnene-3,20-dione (17OHP), 4-Androstene-3,17-dione (A-dione), testosterone (T), and estradiol-17 beta (E2) in both spermatic and peripheral veins were measured. 17-alpha-Hydroxyprogesterone 117-155 hypertrichosis 2 (generalised, congenital) Homo sapiens 71-74 2180429-9 1990 P450c17-dependent C17,(20)-lyase activity toward 17 alpha-hydroxyprogesterone was detected to lesser extents in the recombinant yeast. 17-alpha-Hydroxyprogesterone 52-77 steroid 17-alpha-hydroxylase/17,20 lyase Bos taurus 0-7 2152934-6 1990 delta 5-17P/17-OHP for PP1 vs. PP2, PP2 vs. PP3, and PP1 vs. PP3 were significantly different (P less than 0.05) by analysis of variance and multiple comparison testing using the Student-Newman-Keuls procedure. 17-alpha-Hydroxyprogesterone 12-18 inorganic pyrophosphatase 1 Homo sapiens 23-26 2152934-6 1990 delta 5-17P/17-OHP for PP1 vs. PP2, PP2 vs. PP3, and PP1 vs. PP3 were significantly different (P less than 0.05) by analysis of variance and multiple comparison testing using the Student-Newman-Keuls procedure. 17-alpha-Hydroxyprogesterone 12-18 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 31-34 34743977-0 2022 17-Hydroxyprogesterone Response to Standard Dose Synacthene Stimulation Test in CYP21A2 Heterozygous Carriers and Non-Carriers in Symptomatic and Asymptomatic Groups: Meta-Analyses. 17-alpha-Hydroxyprogesterone 0-22 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 80-87 2153199-3 1990 Their spontaneous and adrenocorticotropic hormone-stimulated blood concentrations of 17 alpha-hydroxyprogesterone, androstenedione, and testosterone were measured initially and were normal. 17-alpha-Hydroxyprogesterone 85-113 proopiomelanocortin Homo sapiens 22-49 25353971-0 2015 Secondary amenorrhoea associated with high serum 17-hydroxyprogesterone levels revealing a heterozygous CYP21A2 mutation in a woman with Addison disease. 17-alpha-Hydroxyprogesterone 49-71 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 104-111 34829455-6 2021 A high value of 17-hydroxyprogesterone was found in 39 patients, in whom strip assay analysis of the CYP21A2 gene was subsequently performed. 17-alpha-Hydroxyprogesterone 16-38 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 101-108 33770316-1 2021 Aldo-keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to inactivate the biologically active progesterone into its corresponding 20 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 151-176 aldo-keto reductase family 1 member C1 Homo sapiens 0-23 33770316-1 2021 Aldo-keto reductase 1C1 (AKR1C1) is a hydroxysteroid dehydrogenase, known to inactivate the biologically active progesterone into its corresponding 20 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 151-176 aldo-keto reductase family 1 member C1 Homo sapiens 25-31 34662099-3 2021 An important branch point in human androgen production is catalyzed by cytochrome P450 CYP17A1 and involves an initial Compound I-mediated hydroxylation at the 17-position of either progesterone (PROG) or pregnenolone (PREG) to form 17-hydroxy derivatives, 17OH-PROG and 17OH-PREG, with approximately similar efficiencies. 17-alpha-Hydroxyprogesterone 257-266 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 87-94 34743977-11 2022 Conclusion: The meta-analyses support the idea that stimulated 17-OHP level has potential to use to determine CYP21A2 carriers. 17-alpha-Hydroxyprogesterone 63-69 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 110-117 34822396-6 2021 As one of the loci was the human leukocyte antigen (HLA) region, we analyzed HLA allele counts and found four HLA subtypes linked to 17-OH-progesterone (17-OHP), including HLA-B*14*02. 17-alpha-Hydroxyprogesterone 153-159 major histocompatibility complex, class I, B Homo sapiens 172-177 34605273-8 2021 The increase in claudin-8 mRNA levels in response to aldosterone was prevented by preincubation with 17-hydroxy progesterone, a mineralocorticoid receptor antagonist, and by inhibition of transcription with actinomycin D. 17-alpha-Hydroxyprogesterone 101-124 claudin 8 Mus musculus 16-25 34605273-8 2021 The increase in claudin-8 mRNA levels in response to aldosterone was prevented by preincubation with 17-hydroxy progesterone, a mineralocorticoid receptor antagonist, and by inhibition of transcription with actinomycin D. 17-alpha-Hydroxyprogesterone 101-124 nuclear receptor subfamily 3, group C, member 2 Mus musculus 128-154 35592511-1 2022 Steroid 21-hydroxylase is an enzyme of the steroid pathway that is involved in the biosynthesis of cortisol and aldosterone by hydroxylation of 17alpha-hydroxyprogesterone and progesterone at the C21 position. 17-alpha-Hydroxyprogesterone 144-171 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-22 34476227-11 2021 The correlation analysis between clinical characteristics and androgen serum levels showed that DBP and BMI had a significant positive correlation with 17OHP. 17-alpha-Hydroxyprogesterone 152-157 D-box binding PAR bZIP transcription factor Homo sapiens 96-99 34476227-12 2021 The median regression analysis showed, only DBP in the adjusted model had a significant positive effect with 17OHP level (P < 0.05), and no significant relationship was observed for other characteristics. 17-alpha-Hydroxyprogesterone 109-114 D-box binding PAR bZIP transcription factor Homo sapiens 44-47 34476227-13 2021 Conclusion: A significant association was found between BMI and DBP with serum concentrations of 17-OHP, suggesting that elevated 17-OHP can lead to an increased risk of cardiovascular disorders in children and adolescents with CAH. 17-alpha-Hydroxyprogesterone 97-103 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 34476227-13 2021 Conclusion: A significant association was found between BMI and DBP with serum concentrations of 17-OHP, suggesting that elevated 17-OHP can lead to an increased risk of cardiovascular disorders in children and adolescents with CAH. 17-alpha-Hydroxyprogesterone 130-136 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 32388791-10 2021 The high serum concentration of 17-OH progesterone was measured at baseline and after 250-mug bolus of synthetic ACTH. 17-alpha-Hydroxyprogesterone 32-50 proopiomelanocortin Homo sapiens 113-117 34231242-0 2021 Reassessment of predictive values of ACTH-stimulated serum 21-deoxycortisol and 17-hydroxyprogesterone to identify CYP21A2 heterozygote carriers and non-classic subjects. 17-alpha-Hydroxyprogesterone 80-102 proopiomelanocortin Homo sapiens 37-41 34231242-3 2021 ACTH-stimulated serum 17-hydroxyprogesterone (17P) and 21-deoxycortisol (21DF) discriminate 21OHD phenotypes effectively, notably if measured simultaneously by LC-MS/MS. 17-alpha-Hydroxyprogesterone 22-44 proopiomelanocortin Homo sapiens 0-4 34231242-3 2021 ACTH-stimulated serum 17-hydroxyprogesterone (17P) and 21-deoxycortisol (21DF) discriminate 21OHD phenotypes effectively, notably if measured simultaneously by LC-MS/MS. 17-alpha-Hydroxyprogesterone 46-49 proopiomelanocortin Homo sapiens 0-4 34231242-12 2021 CONCLUSION: Reassessed ACTH-stimulated 21DF and 17P cutoffs by LC-MS/MS (60 and 310 ng/dL, respectively) correctly recognized 82.5% HZ plus NC, but combined precursor-to-product ratio ((21DF+17P)/F) cutoff of 12 was superior, identifying 92.3% HZ plus NC. 17-alpha-Hydroxyprogesterone 48-51 proopiomelanocortin Homo sapiens 23-27 34231242-12 2021 CONCLUSION: Reassessed ACTH-stimulated 21DF and 17P cutoffs by LC-MS/MS (60 and 310 ng/dL, respectively) correctly recognized 82.5% HZ plus NC, but combined precursor-to-product ratio ((21DF+17P)/F) cutoff of 12 was superior, identifying 92.3% HZ plus NC. 17-alpha-Hydroxyprogesterone 191-194 proopiomelanocortin Homo sapiens 23-27 35592511-1 2022 Steroid 21-hydroxylase is an enzyme of the steroid pathway that is involved in the biosynthesis of cortisol and aldosterone by hydroxylation of 17alpha-hydroxyprogesterone and progesterone at the C21 position. 17-alpha-Hydroxyprogesterone 144-171 transducin (beta)-like 1X-linked receptor 1 Mus musculus 196-199 35394864-3 2022 In the present study, we identified GPR126 as a membrane receptor for both progesterone and 17-hydroxyprogesterone and triggered its downstream G protein signaling. 17-alpha-Hydroxyprogesterone 92-114 adhesion G protein-coupled receptor G6 Homo sapiens 36-42 35480632-8 2022 The homeostatic model assessment of insulin resistance was positively associated with androstenedione (beta = 0.071, P = .032), estradiol (beta = 0.091, P = .009), estrone (beta = 0.075, P = 0.009), and 17-alpha-hydroxyprogesterone (beta = 0.157, P = .001). 17-alpha-Hydroxyprogesterone 203-231 insulin Homo sapiens 36-43 35287432-6 2022 First, we report studies of solvent isotope effects for the N202S CYP17A1 mutant in the presence of 17OH-PREG and 17OH-PROG, which suggest that the ferric peroxo species is the predominant catalytically active intermediate in the lyase step. 17-alpha-Hydroxyprogesterone 114-123 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 66-73 35366770-5 2022 This P450c17 cytochrome gene is a critical steroidogenesis regulator which performs two distinct activities: 17 alpha-hydroxylase activity (converting pregnenolone to 17-hydroxypregnenolone and progesterone to 17-hydroxyprogesterone, these precursors are further processed to provide glucocorticoids and sex hormones) and 17, 20-lyase activity (which converts 17-hydroxypregnenolone to DHEA). 17-alpha-Hydroxyprogesterone 210-232 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 5-12 35225789-3 2022 Because Cyp17a1 plays key roles in hydroxylation of pregnenolone and progesterone (P4), and converts 17alpha-hydroxypregnenolone to dehydroepiandrosterone and 17alpha-hydroxyprogesterone to androstenedione, we hypothesize that the unexpected phenotype in cyp17a1-/-;androgen receptor (ar)-/- zebrafish may be mediated through an augmentation of progestin/nuclear progestin receptor (nPgr) signaling. 17-alpha-Hydroxyprogesterone 159-186 cytochrome P450, family 17, subfamily A, polypeptide 1 Danio rerio 8-15 35225789-3 2022 Because Cyp17a1 plays key roles in hydroxylation of pregnenolone and progesterone (P4), and converts 17alpha-hydroxypregnenolone to dehydroepiandrosterone and 17alpha-hydroxyprogesterone to androstenedione, we hypothesize that the unexpected phenotype in cyp17a1-/-;androgen receptor (ar)-/- zebrafish may be mediated through an augmentation of progestin/nuclear progestin receptor (nPgr) signaling. 17-alpha-Hydroxyprogesterone 159-186 androgen receptor Danio rerio 255-283 35225789-3 2022 Because Cyp17a1 plays key roles in hydroxylation of pregnenolone and progesterone (P4), and converts 17alpha-hydroxypregnenolone to dehydroepiandrosterone and 17alpha-hydroxyprogesterone to androstenedione, we hypothesize that the unexpected phenotype in cyp17a1-/-;androgen receptor (ar)-/- zebrafish may be mediated through an augmentation of progestin/nuclear progestin receptor (nPgr) signaling. 17-alpha-Hydroxyprogesterone 159-186 androgen receptor Danio rerio 285-287 35187416-3 2022 At 1 nM steroid, the elephant shark PR is activated by progesterone, 17-hydroxy-progesterone, 20beta-hydroxy-progesterone, 11-deoxycorticosterone (21-hydroxyprogesterone), and 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 69-92 progesterone receptor Callorhinchus milii 36-38 2541588-9 1989 Moreover, the conversion of exogenously added androgen precursors (progesterone and 17 alpha-hydroxyprogesterone) to testosterone by human chorionic gonadotropin-stimulated cells was suppressed by interleukin-1 beta suggesting that the activity of the 17 alpha-hydroxylase enzyme may be decreased. 17-alpha-Hydroxyprogesterone 84-112 interleukin 1 beta Homo sapiens 197-215 2615366-1 1989 The stereospecificity of hydrogen transfer between steroid (17-hydroxyprogesterone) and both natural cofactors by bovine testicular 20 alpha-hydroxysteroid dehydrogenase (20 alpha-HSD) has been determined. 17-alpha-Hydroxyprogesterone 60-82 placental and ovary 20alpha hydroxysteroid dehydrogenase protein Bos taurus 171-183 2615366-3 1989 The resulting [4B-3H]NADH and [4B-3H]NADPH were purified by ion-exchange chromatography and separately incubated with molar excess of 17-hydroxyprogesterone as substrate in the presence of 20 alpha-HSD. 17-alpha-Hydroxyprogesterone 134-156 placental and ovary 20alpha hydroxysteroid dehydrogenase protein Bos taurus 189-201 2687042-1 1989 Specific antiserum for 17-hydroxyprogesterone (17-OH-P) was prepared by immunizing 7 alpha-(2-carboxyethylthio)-17-OH-P conjugated bovine serum albumin (BSA) in rabbits. 17-alpha-Hydroxyprogesterone 23-45 albumin Oryctolagus cuniculus 138-151 2687042-1 1989 Specific antiserum for 17-hydroxyprogesterone (17-OH-P) was prepared by immunizing 7 alpha-(2-carboxyethylthio)-17-OH-P conjugated bovine serum albumin (BSA) in rabbits. 17-alpha-Hydroxyprogesterone 47-54 albumin Oryctolagus cuniculus 138-151 2531534-3 1989 HCG further augmented 17-OHP production significantly at 96, 144 and 192 hours of culture. 17-alpha-Hydroxyprogesterone 22-28 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 2555382-7 1989 Increased P450scc activity, which increased the conversion of cholesterol to pregnenolone, apparently permitted the 17,20-lyase activity of P450c17 to become rate limiting, thus accounting for the increased secretion of 17OHP. 17-alpha-Hydroxyprogesterone 220-225 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 10-17 2555382-7 1989 Increased P450scc activity, which increased the conversion of cholesterol to pregnenolone, apparently permitted the 17,20-lyase activity of P450c17 to become rate limiting, thus accounting for the increased secretion of 17OHP. 17-alpha-Hydroxyprogesterone 220-225 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 140-147 2808702-1 1989 The 21-hydroxylation of progesterone to deoxycorticosterone (DOC) and of 17-hydroxyprogesterone to 11-deoxycortisol in the human adrenal cortex is mediated by a single enzyme termed P450c21. 17-alpha-Hydroxyprogesterone 73-95 cytochrome P450, family 21, subfamily a, polypeptide 1 Rattus norvegicus 182-189 2550509-4 1989 17-OHP increased after CRH injection, but its response linearly with age. 17-alpha-Hydroxyprogesterone 0-6 corticotropin releasing hormone Homo sapiens 23-26 2555033-1 1989 The ACTH test is important when hirsutism occurs in women with a slight 21-hydroxylase deficiency, and normal basal 17-OH Progesterone (17-OH-P/plasma levels). 17-alpha-Hydroxyprogesterone 116-134 proopiomelanocortin Homo sapiens 4-8 2555033-1 1989 The ACTH test is important when hirsutism occurs in women with a slight 21-hydroxylase deficiency, and normal basal 17-OH Progesterone (17-OH-P/plasma levels). 17-alpha-Hydroxyprogesterone 136-143 proopiomelanocortin Homo sapiens 4-8 2844399-9 1988 The LHRH analogue stimulated circulating progesterone and suppressed 17-hydroxyprogesterone levels. 17-alpha-Hydroxyprogesterone 69-91 gonadotropin releasing hormone 1 Rattus norvegicus 4-8 2720843-1 1989 The cofactor requirement of purified 20 beta-hydroxysteroid dehydrogenase from cytosol fraction of neonatal pig testis, in the reduction of 17 alpha-hydroxyprogesterone was investigated. 17-alpha-Hydroxyprogesterone 140-168 carbonyl reductase [NADPH] 1 Sus scrofa 37-73 3139743-7 1988 ACTH stimulation induced a subnormal rise of cortisol and 11 beta-hydroxyandrostenedione, a low or absent rise of dehydroepiandrosterone, 17 alpha-hydroxypregnenolone, androstenedione and 17 alpha-hydroxyprogesterone contrasting with a marked rise of pregnenolone and progesterone. 17-alpha-Hydroxyprogesterone 188-216 proopiomelanocortin Homo sapiens 0-4 3220046-2 1988 Her baseline and ACTH-stimulated plasma 17-hydroxy pregnenolone, dehydroepiandrosterone and dehydroepiandrosterone sulfate were increased whereas plasma 17-hydroxy progesterone and androstenedione were normal and responded poorly to ACTH. 17-alpha-Hydroxyprogesterone 153-176 proopiomelanocortin Homo sapiens 17-21 2837498-8 1988 The patients" unstimulated serum 17-OHP levels exceeded those in the normal subjects at all times (P less than 0.01) and exhibited diurnal variability paralleling that of ACTH and cortisol. 17-alpha-Hydroxyprogesterone 33-39 proopiomelanocortin Homo sapiens 171-175 3223911-0 1988 Specific accumulation of 17 alpha-hydroxyprogesterone in microsomal membranes during the process of cytochrome P-450(C-17)-catalysed androgen biosynthesis. 17-alpha-Hydroxyprogesterone 25-53 cytokine like 1 Homo sapiens 100-121 3223911-2 1988 A complete dynamic analysis of cytochrome P-450(C-17)-catalysed androgen biosynthesis from a single dose of progesterone and 17 alpha-hydroxyprogesterone in a double-label double-substrate experiment was performed in order to elucidate the controversial intermediacy of 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 125-153 cytokine like 1 Homo sapiens 31-52 3223911-2 1988 A complete dynamic analysis of cytochrome P-450(C-17)-catalysed androgen biosynthesis from a single dose of progesterone and 17 alpha-hydroxyprogesterone in a double-label double-substrate experiment was performed in order to elucidate the controversial intermediacy of 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 270-298 cytokine like 1 Homo sapiens 31-52 3418804-2 1988 The congenital adrenal hyperplasia was confirmed by extremely high levels of basal serum 17 alpha-hydroxy-progesterone and urinary pregnantriol as well as an exaggerated response of 17 alpha-hydroxyprogesterone to adrenocorticotropic hormone. 17-alpha-Hydroxyprogesterone 182-210 proopiomelanocortin Homo sapiens 214-241 3260876-2 1988 In the presence of low concentrations of LH or in its absence interleukin-1 beta markedly stimulates the production of C19-steroids (testosterone and androstenedione) and C21-steroids (progesterone, 17 alpha-hydroxyprogesterone, 20 alpha-hydroxypregn-4-en-3-one). 17-alpha-Hydroxyprogesterone 202-227 interleukin 1 beta Rattus norvegicus 62-80 3267357-2 1988 In addition, the response of serum 17-OHP to intravenous ACTH was determined in obligate carrier parents, and 17-OHP concentration of amniotic fluid was also measured at 16 weeks of gestation. 17-alpha-Hydroxyprogesterone 35-41 proopiomelanocortin Homo sapiens 57-61 3267357-4 1988 Although the post stimulation response of 17-OHP to ACTH in the mother (I-2) was significantly higher than that of normal control, the post stimulation levels of 17-OHP were in normal range in the father (I-1). 17-alpha-Hydroxyprogesterone 42-48 proopiomelanocortin Homo sapiens 52-56 3579438-3 1987 However, it is readily diagnosed by a marked increase in 17 alpha-hydroxyprogesterone levels after adrenocorticotropic hormone stimulation. 17-alpha-Hydroxyprogesterone 57-85 proopiomelanocortin Homo sapiens 99-126 2846977-8 1988 The conversion of exogenously added androgen precursors (progesterone (P) and 17 alpha-hydroxyprogesterone) to T by hCG-stimulated cells was suppressed by the addition of TGF-beta. 17-alpha-Hydroxyprogesterone 78-106 transforming growth factor beta 1 Homo sapiens 171-179 3427059-7 1987 6 beta-hydroxylation of progesterone was catalyzed by four isozymes with cytochrome P-450g being the most efficient, and 15 alpha-hydroxyprogesterone was formed as a minor metabolite by cytochromes P-450g, P-450h, and P-450i. 17-alpha-Hydroxyprogesterone 124-149 cytochrome P450, family 2, subfamily c, polypeptide 13 Rattus norvegicus 198-224 3317221-0 1987 [Comparison of the kinetics of the response of salivary and plasma 17-hydroxyprogesterone to the administration of HCG in men]. 17-alpha-Hydroxyprogesterone 67-89 hypertrichosis 2 (generalised, congenital) Homo sapiens 115-118 3317221-1 1987 17-hydroxyprogesterone (17-OHP) time course response to hCG (5,000 IU) was studied simultaneously in the saliva and the plasma of 12 adult healthy men. 17-alpha-Hydroxyprogesterone 0-22 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 3317221-1 1987 17-hydroxyprogesterone (17-OHP) time course response to hCG (5,000 IU) was studied simultaneously in the saliva and the plasma of 12 adult healthy men. 17-alpha-Hydroxyprogesterone 24-30 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 3039770-3 1987 Eight of 21 patients had supranormal post-ACTH serum 17-OHP concentration (57-153 nmol/l) with low normal cortisol concentration. 17-alpha-Hydroxyprogesterone 53-59 proopiomelanocortin Homo sapiens 42-46 3039770-7 1987 Patients with basal morning 17-OHP concentration and 17-OHP to cortisol ratio above reference range should be given an ACTH test. 17-alpha-Hydroxyprogesterone 28-34 proopiomelanocortin Homo sapiens 119-123 3039770-7 1987 Patients with basal morning 17-OHP concentration and 17-OHP to cortisol ratio above reference range should be given an ACTH test. 17-alpha-Hydroxyprogesterone 53-59 proopiomelanocortin Homo sapiens 119-123 3121936-3 1987 Simultaneous administration of a single injection of the agonist (LHRH alpha) and hCG blunted the plasma testosterone response observed 24 h after LHRH alpha alone, enhanced the secretion of oestradiol without affecting 17-hydroxy-progesterone and aggravated the late steroidogenic block at the 17,20-lyase locus. 17-alpha-Hydroxyprogesterone 220-243 chorionic gonadotropin subunit beta 5 Homo sapiens 82-85 3560940-0 1987 Comparison of saliva and plasma 17-hydroxyprogesterone time-course response to hCG administration in normal men. 17-alpha-Hydroxyprogesterone 32-54 hypertrichosis 2 (generalised, congenital) Homo sapiens 79-82 3560940-1 1987 17-Hydroxyprogesterone (17-OHP) time-course response to hCG (5000 IU) was studied simultaneously in the saliva and the plasma of 12 adult healthy men. 17-alpha-Hydroxyprogesterone 0-22 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 3808511-3 1987 In all the members of this family who were tested, the response of 17-hydroxyprogesterone and progesterone to adrenocorticotropic hormone stimulation was either normal or of the type seen in heterozygotes for congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 17-alpha-Hydroxyprogesterone 67-89 proopiomelanocortin Homo sapiens 110-137 3560940-1 1987 17-Hydroxyprogesterone (17-OHP) time-course response to hCG (5000 IU) was studied simultaneously in the saliva and the plasma of 12 adult healthy men. 17-alpha-Hydroxyprogesterone 24-30 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 3098014-0 1986 Failure of GnRH analogue to inhibit serum concentrations of testosterone and 17 alpha-hydroxyprogesterone in hCG-substituted hypogonadotropic hypogonadism. 17-alpha-Hydroxyprogesterone 77-105 gonadotropin releasing hormone 1 Homo sapiens 11-15 3795953-3 1986 Progesterone and 17 alpha-hydroxyprogesterone, the enzyme"s substrates, bound stoichiometrically to microsomal P-450 with unusually high affinity (Kd = 23-51 nM). 17-alpha-Hydroxyprogesterone 17-45 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 111-116 3470004-1 1986 Rat ovarian 20 alpha-hydroxysteroid dehydrogenase plays a pivotal role in leuteolysis and parturition by catalysing the reduction of progesterone to give the progestationally inactive steroid 20 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 195-220 aldo-keto reductase family 1, member C3 Rattus norvegicus 12-49 3018024-3 1986 The 17-hydroxyprogesterone response to ACTH was much greater in these girls (360 and 540 ng/dl) than in the girls with other types of precocious puberty (mean +/- SD, 71 +/- 15 ng/dl) or in normal prepubertal girls (80 +/- 20 ng/dl). 17-alpha-Hydroxyprogesterone 4-26 proopiomelanocortin Homo sapiens 39-43 3018024-6 1986 However, 17-hydroxyprogesterone responses to ACTH were still elevated (160 and 350 ng/dl). 17-alpha-Hydroxyprogesterone 9-31 proopiomelanocortin Homo sapiens 45-49 3089339-11 1986 Quantitation of steroid intermediates in the testosterone biosynthetic pathway revealed that the stimulatory effect of 3 ng/ml rPRL on testosterone production was associated with 1.3- and 2.8-fold increases in accumulation of androstenedione and 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 246-274 prolactin Rattus norvegicus 127-131 3017791-2 1986 It is demonstrated that EGF directly stimulates the output of C19-steroids (testosterone and androstenedione) as well as C21-steroids (progesterone, 17 alpha-hydroxyprogesterone and 20 alpha-hydroxypregn-4-en-3-one) in all systems studied. 17-alpha-Hydroxyprogesterone 152-177 epidermal growth factor like 1 Rattus norvegicus 24-27 3013919-11 1986 If doubtful results are obtained, i.e. serum 17-OHP levels between 2 and 5 ng/ml, an ACTH test must be performed. 17-alpha-Hydroxyprogesterone 45-51 proopiomelanocortin Homo sapiens 85-89 3013919-12 1986 Post-ACTH serum 17-OHP levels exceeding 10 ng/ml confirm the diagnosis of LOHD. 17-alpha-Hydroxyprogesterone 16-22 proopiomelanocortin Homo sapiens 5-9 3009598-4 1986 We observed elevated baseline (greater than 4 ng/ml) and ACTH-stimulated 17-hydroxyprogesterone levels, increased baseline Androstenedione levels, slightly elevated or normal DHEA-S and Testosterone values and subnormal response of Cortisol levels to ACTH in patients and in the HLA-identical sibs, reduced SHBG levels in patients but not in their identical sibs. 17-alpha-Hydroxyprogesterone 73-95 proopiomelanocortin Homo sapiens 57-61 3963065-7 1986 Oxytocin in corpus luteum correlated significantly with its ipsilateral ovarian vein level of oxytocin, estrone, progesterone, and 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 131-159 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 3963065-8 1986 Our findings demonstrate that oxytocin is present and probably produced in corpus luteum and secreted into its ovarian vein; it may regulate corpus luteum release of progesterone, 17 alpha-hydroxyprogesterone, and estrone. 17-alpha-Hydroxyprogesterone 183-208 oxytocin/neurophysin I prepropeptide Homo sapiens 30-38 3013005-3 1986 The results showed an association between "abnormal" DR1 and 21-OH-defL (elevated rates of 17 alpha-hydroxyprogesterone [17-OHP] increase and elevated peak 17-OHP values following ACTH stimulation). 17-alpha-Hydroxyprogesterone 91-119 down-regulator of transcription 1 Mus musculus 53-56 3013005-3 1986 The results showed an association between "abnormal" DR1 and 21-OH-defL (elevated rates of 17 alpha-hydroxyprogesterone [17-OHP] increase and elevated peak 17-OHP values following ACTH stimulation). 17-alpha-Hydroxyprogesterone 121-127 down-regulator of transcription 1 Mus musculus 53-56 3013005-3 1986 The results showed an association between "abnormal" DR1 and 21-OH-defL (elevated rates of 17 alpha-hydroxyprogesterone [17-OHP] increase and elevated peak 17-OHP values following ACTH stimulation). 17-alpha-Hydroxyprogesterone 156-162 down-regulator of transcription 1 Mus musculus 53-56 3944128-2 1986 Interaction of the steroid substrates, 17 alpha-hydroxyprogesterone and progesterone, with P-450C21 in the liposomes was studied in the equilibrium state by measuring substrate-induced spectral change. 17-alpha-Hydroxyprogesterone 39-67 steroid 21-hydroxylase Bos taurus 91-99 3944128-4 1986 Partition coefficients, determined by equilibrium dialysis and the Hummel-Dreyer method, were 3500 for progesterone and 2000 for 17 alpha-hydroxyprogesterone at 25 degrees C. The binding process of the substrates to P-450C21 in the liposomes and their dissociation were measured by a stopped flow method. 17-alpha-Hydroxyprogesterone 132-157 steroid 21-hydroxylase Bos taurus 216-224 3997269-5 1985 The response of 17-OHP, T, E2 and the 17-OHP/T ratio to hCG was similar in short-term and long-term tamoxifen-treated men as well as in 6 untreated eugonadal male controls. 17-alpha-Hydroxyprogesterone 16-22 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 4043519-5 1985 In the individual rats liver-type lipase activity in the ovaries was strongly correlated with serum progesterone and 20 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 120-145 lipase G, endothelial type Rattus norvegicus 34-40 3486324-3 1986 hCG produced an increase in 17-hydroxyprogesterone, and androstenedione, but a drastic decrease in enzyme activity within 6 h; this could be largely prevented by pretreatment of the rats with cycloheximide or aminoglutethimide but actinomycin D was ineffective. 17-alpha-Hydroxyprogesterone 28-50 glycoprotein hormones, alpha polypeptide Homo sapiens 0-3 3022521-4 1986 In congenital adrenal hyperplasia, plasma ACTH concentrations mirror, together with 17-alpha-hydroxyprogesterone, the extent of ACTH suppression. 17-alpha-Hydroxyprogesterone 84-112 proopiomelanocortin Homo sapiens 128-132 3010006-9 1986 After 12 months of buserelin injections, the changes in hCG-stimulated rat testes are an increased ratio of progesterone/17-OH-progesterone (inhibition of 17-hydroxylase), a reduced capacity for secretion of androstenedione and testosterone (block of 17,20-desmolase), and increased 5 alpha-pregnane-3,20-dione (this steroid inhibits the 17,20-desmolase, similarly to progesterone). 17-alpha-Hydroxyprogesterone 121-139 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 2982895-6 1985 After ACTH injection, cortisol, DHEA, 17-OHP, and androstenedione increased significantly. 17-alpha-Hydroxyprogesterone 38-44 proopiomelanocortin Homo sapiens 6-10 2982895-8 1985 The mean 17-OHP response to ACTH in girls with PA was significantly higher than that in girls and women whose pubertal development was normal. 17-alpha-Hydroxyprogesterone 9-15 proopiomelanocortin Homo sapiens 28-32 3997269-5 1985 The response of 17-OHP, T, E2 and the 17-OHP/T ratio to hCG was similar in short-term and long-term tamoxifen-treated men as well as in 6 untreated eugonadal male controls. 17-alpha-Hydroxyprogesterone 38-44 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 6322821-9 1983 On the contrary both F and 17-OHP plasma values strongly enhanced at 45" but a further increase of their values after every ACTH stimulus was also observed. 17-alpha-Hydroxyprogesterone 27-33 proopiomelanocortin Homo sapiens 124-128 6504879-2 1984 It was discovered that hCG had an acute stimulating effect on testicular secretion of testosterone, androstendione and 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 119-141 chorionic gonadotropin subunit beta 5 Homo sapiens 23-26 6504879-4 1984 Unlike the initial response, repeated stimulation with hCG gave rise to dissociation in the time-course of testosterone and 17-hydroxyprogesterone responses. 17-alpha-Hydroxyprogesterone 124-146 chorionic gonadotropin subunit beta 5 Homo sapiens 55-58 6327405-0 1984 Basal and adrenocorticotropic hormone-stimulated serum 17 alpha-hydroxyprogesterone in men with idiopathic infertility. 17-alpha-Hydroxyprogesterone 55-83 proopiomelanocortin Homo sapiens 10-37 6327405-1 1984 Basal serum 17 alpha-hydroxyprogesterone (17-OHP) concentrations and the 17-OHP response to acute adrenocorticotropic hormone administration were studied in infertile men with idiopathic oligospermia to determine the prevalence of attenuated 21-hydroxylase deficiency. 17-alpha-Hydroxyprogesterone 73-79 proopiomelanocortin Homo sapiens 98-125 6327405-4 1984 Following the intravenous administration of 0.25 mg of synthetic adrenocorticotropic hormone (cosyntropin) to these two men and to eight additional infertile men, the mean increase in 17-OHP concentrations was 0.84 +/- 0.15 ng/ml, a response which was similar to that of normal men (0.94 +/- 0.26 ng/ml). 17-alpha-Hydroxyprogesterone 184-190 proopiomelanocortin Homo sapiens 65-92 6315754-7 1984 In contrast, bovine cells converted pregnenolone to progesterone, with or without prior exposure to ACTH, which was then converted to 17-hydroxyprogesterone, with minimal formation of dehydroepiandrosterone. 17-alpha-Hydroxyprogesterone 134-156 proopiomelanocortin Homo sapiens 100-104 3967847-7 1985 The activities of the 3 beta-HSD, 17-OH, 17,20-D, 17-KSR and aromatase were measured using as substrates 14C dehydroepiandrosterone, progesterone, 17-hydroxyprogesterone, androstenedione and testosterone, respectively. 17-alpha-Hydroxyprogesterone 147-169 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Rattus norvegicus 22-32 3967847-7 1985 The activities of the 3 beta-HSD, 17-OH, 17,20-D, 17-KSR and aromatase were measured using as substrates 14C dehydroepiandrosterone, progesterone, 17-hydroxyprogesterone, androstenedione and testosterone, respectively. 17-alpha-Hydroxyprogesterone 147-169 kinase suppressor of ras 1 Rattus norvegicus 53-56 4009422-0 1985 [Steroid 17 alpha-hydroxylase-C17,20 lyase (cytochrome P-450) from porcine adrenocortical microsomes: inhibition of lyase activity by progesterone and inhibition of hydroxylase activity by 17 alpha-hydroxyprogesterone]. 17-alpha-Hydroxyprogesterone 189-217 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-60 6440111-6 1984 hCG induced significant increases in serum pregnenolone, 17-hydroxyprogesterone, androstenedione, testosterone, and dihydrotestosterone. 17-alpha-Hydroxyprogesterone 57-79 chorionic gonadotropin subunit beta 5 Homo sapiens 0-3 6086556-9 1984 Following five months of daily treatment with the LHRH agonist, the main findings are a decreased response of pregnenolone, P, 17-OH-P and androst-5-ene-3 beta, 17 beta-diol, and an increased DHT, 3 alpha-diol and androstane-3 beta, 17 beta-diol responsiveness. 17-alpha-Hydroxyprogesterone 127-134 gonadotropin releasing hormone 1 Rattus norvegicus 50-54 6100121-0 1984 21-Deoxycortisol and 17-hydroxyprogesterone responses to ACTH in hirsute women. 17-alpha-Hydroxyprogesterone 21-43 proopiomelanocortin Homo sapiens 57-61 6308008-5 1983 The increase in synthesis of cytochrome P-450C21 was associated with an increase (3-6 fold) in both total cytochrome P-450 content and in the type I absorbance change induced by 17 alpha-hydroxyprogesterone in microsomes prepared from ACTH-treated cells, as compared with that in microsomes from control cells. 17-alpha-Hydroxyprogesterone 181-206 steroid 21-hydroxylase Bos taurus 40-48 6672460-1 1983 The separation of several C21 steroids, such as 17-hydroxyprogesterone, and androgens, such as testosterone, from the non-polar steroids like 16-androstenes has been achieved on one thin-layer chromatographic plate using a two-dimensional technique. 17-alpha-Hydroxyprogesterone 48-70 TBL1X/Y related 1 Homo sapiens 26-29 6311859-3 1983 In addition to the often exaggerated stimulation by ACTH of the immediate precursor to 21-hydroxylation, 17 alpha-hydroxyprogesterone, the heterozygotes can now be characterized further by the impaired ACTH responses of mineralocorticoids distal to the block in the zona fasciculata; the ACTH-stimulated 17 alpha-hydroxyprogesterone/18-hydroxydeoxycorticosterone ratio was greater than normal in 94% of the heterozygotes. 17-alpha-Hydroxyprogesterone 105-133 proopiomelanocortin Homo sapiens 52-56 6311859-3 1983 In addition to the often exaggerated stimulation by ACTH of the immediate precursor to 21-hydroxylation, 17 alpha-hydroxyprogesterone, the heterozygotes can now be characterized further by the impaired ACTH responses of mineralocorticoids distal to the block in the zona fasciculata; the ACTH-stimulated 17 alpha-hydroxyprogesterone/18-hydroxydeoxycorticosterone ratio was greater than normal in 94% of the heterozygotes. 17-alpha-Hydroxyprogesterone 304-332 proopiomelanocortin Homo sapiens 202-206 6311859-3 1983 In addition to the often exaggerated stimulation by ACTH of the immediate precursor to 21-hydroxylation, 17 alpha-hydroxyprogesterone, the heterozygotes can now be characterized further by the impaired ACTH responses of mineralocorticoids distal to the block in the zona fasciculata; the ACTH-stimulated 17 alpha-hydroxyprogesterone/18-hydroxydeoxycorticosterone ratio was greater than normal in 94% of the heterozygotes. 17-alpha-Hydroxyprogesterone 304-332 proopiomelanocortin Homo sapiens 202-206 6196179-6 1983 When the cytochrome P-450 obtained from the PMSG-treated rats was subjected to spectrometric analysis of binding with progesterone and 17 alpha-hydroxy-progesterone, type I spectra were obtained for both steroids, indicating that the steroids bound to the cytochrome as substrate. 17-alpha-Hydroxyprogesterone 135-164 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 9-25 6310249-3 1983 However, these deficiencies have been inferred to derive from a single aberration in C11 beta-hydroxylase, whereby the enzyme acquires an affinity towards 21-deoxy precursors (i.e. 17-OH-progesterone) of cortisol and diminishes its activity against its regular 21-hydroxy intermediate 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 181-199 endogenous retrovirus group K member 20 Homo sapiens 85-93 6863482-1 1983 In normal men a single dose of hCG induces an increase in plasma testosterone (T) and 17 alpha-hydroxyprogesterone (17 alpha-OHP) 2-4 h after the injection; after 24-36 h a maximum increase in plasma 17 beta-estradiol (E2) and 17 alpha-OHP occurs followed by a second surge in T after 48-96 h. The present investigation focuses on the effect of a single dose of hCG (3500 IU/m2 body surface) on testicular steroid production in 12 boys aged 13 months to 12 yr. 17-alpha-Hydroxyprogesterone 86-114 hypertrichosis 2 (generalised, congenital) Homo sapiens 31-34 6296191-1 1983 To determine if angiotensin II stimulates an increase in the plasma concentration of androstenedione, dehydroepiandrosterone, 17-hydroxyprogesterone, or ACTH in a patient with congenital 21-hydroxylase deficiency, we measured these plasma concentrations before and after the plasma angiotensin II concentration was increased by upright posture and angiotensin II infusion in a surgically castrate XX adult patient with this disorder. 17-alpha-Hydroxyprogesterone 126-148 angiotensinogen Homo sapiens 16-30 6299703-10 1983 Similarly, GnRH decreased hCG-induced testosterone and androstenedione production in cells incubated with 10(-5) M 17 alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 118-143 gonadotropin releasing hormone 1 Rattus norvegicus 11-15 6300159-1 1983 We have studied the response of blood levels of progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, and cortisol to acute ACTH stimulation in children with isolated GH deficiency. 17-alpha-Hydroxyprogesterone 62-84 proopiomelanocortin Homo sapiens 126-130 6339857-1 1983 An in vitro perifusion system was used to investigate the effect of progesterone (P4) and 20 alpha-hydroxyprogesterone (20 alpha-OHP) on the release of GnRH from isolated hypothalamic tissue of the adult ovariectomized estradiol-17 beta primed rat. 17-alpha-Hydroxyprogesterone 93-118 gonadotropin releasing hormone 1 Rattus norvegicus 152-156 6299703-7 1983 The inhibitory effect of GnRH on testosterone production (93% inhibition) was associated with decreases in hCG-induced 17 alpha-hydroxyprogesterone (39%) and delta 4-androstenedione (82%), but was not accompanied by a decrease in progesterone production. 17-alpha-Hydroxyprogesterone 119-147 gonadotropin releasing hormone 1 Rattus norvegicus 25-29 6135519-8 1983 The responses of serum oestradiol and 17-hydroxyprogesterone to hCG appeared later during the boys" development than the response of serum testosterone. 17-alpha-Hydroxyprogesterone 38-60 hypertrichosis 2 (generalised, congenital) Homo sapiens 64-67 6297629-9 1982 Exogenous progesterone and 17 alpha-hydroxyprogesterone augmented hCG-stimulated testosterone production. 17-alpha-Hydroxyprogesterone 27-55 hypertrichosis 2 (generalised, congenital) Homo sapiens 66-69 6303639-6 1983 Plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, 17 alpha-hydroxyprogesterone and 17-hydroxy, 20-dihydroprogesterone were all increased by ACTH treatment. 17-alpha-Hydroxyprogesterone 72-100 proopiomelanocortin Homo sapiens 162-166 6817798-2 1982 The absolute high spin contents of substrate-free, progesterone-bound and 17 alpha-hydroxyprogesterone-bound P-450C21 were estimated from the analysis of thermally induced difference spectra to be 25, 78 and 94% at 25 degrees C, respectively, in 50 mM potassium phosphate buffer (pH 7.2) containing 20% glycerol, 0.1 mM EDTA and 0.5% Emulgen 913. 17-alpha-Hydroxyprogesterone 77-102 steroid 21-hydroxylase Bos taurus 109-117 7186685-7 1982 HCG increased the conversion of pregnenolone to progesterone and 17-hydroxyprogesterone (17-hydroxy-4-pregnene-3,20-dione) on 5d. 17-alpha-Hydroxyprogesterone 65-87 chorionic gonadotropin subunit beta 5 Homo sapiens 0-3 7173479-9 1982 In the case of progesterone and 17-hydroxyprogesterone a significant increase was found following the hCG injections. 17-alpha-Hydroxyprogesterone 32-54 chorionic gonadotropin subunit beta 5 Homo sapiens 102-105 6291906-9 1982 Studies on the metabolism of steroid hormones revealed that PRL decreased LH-stimulated androsterone and 5 alpha-androstane-3 alpha, 17 beta-diol accumulation by 99%, androstenedione by 94%, testosterone by 90%, dehydroepiandrosterone by more than 80%, pregnenolone and 17 alpha-hydroxyprogesterone by 80%, 17 alpha-hydroxypregnenolone by 84%, and progesterone by 71%. 17-alpha-Hydroxyprogesterone 270-298 prolactin Rattus norvegicus 60-63 6952965-6 1982 A close correlation was seen between 17 beta-hydroxysteroid dehydrogenase activity and concentrations of estradiol, estrone, testosterone, and 17 alpha-hydroxyprogesterone; the last four also correlated significantly with beta-choriogonadotropin in molar pregnancies, whether benign or invasive. 17-alpha-Hydroxyprogesterone 143-171 hydroxysteroid 17-beta dehydrogenase 7 Homo sapiens 37-73 7130777-5 1982 When hCG was administered, P and 17-OHP showed a trend to elevate in Group A, but they showed a trend to decline in Group B. 17-alpha-Hydroxyprogesterone 33-39 hypertrichosis 2 (generalised, congenital) Homo sapiens 5-8 6797954-8 1981 When compared with these elevated values, the response of serum 17-hydroxyprogesterone, dehydroepiandrosterone, androstenedione and testosterone to hCG were diminished. 17-alpha-Hydroxyprogesterone 64-86 hypertrichosis 2 (generalised, congenital) Homo sapiens 148-151 7113599-1 1982 A single injection of 1500 IU of human chorionic gonadotrophin (hCG) in normal men, induced a block in the conversion of 17-hydroxyprogesterone (17-OHP) to testosterone (T) which reached its maximum 24 h after hCG loading. 17-alpha-Hydroxyprogesterone 121-143 hypertrichosis 2 (generalised, congenital) Homo sapiens 64-67 7113599-1 1982 A single injection of 1500 IU of human chorionic gonadotrophin (hCG) in normal men, induced a block in the conversion of 17-hydroxyprogesterone (17-OHP) to testosterone (T) which reached its maximum 24 h after hCG loading. 17-alpha-Hydroxyprogesterone 145-151 hypertrichosis 2 (generalised, congenital) Homo sapiens 64-67 7113599-4 1982 hCG administration one week after the priming dose elicited an increase in the ratio 17-OHP to T, which was about twice as high as after the first hCG injection. 17-alpha-Hydroxyprogesterone 85-91 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 7113599-4 1982 hCG administration one week after the priming dose elicited an increase in the ratio 17-OHP to T, which was about twice as high as after the first hCG injection. 17-alpha-Hydroxyprogesterone 85-91 hypertrichosis 2 (generalised, congenital) Homo sapiens 147-150 7068111-4 1982 17-OH-progesterone values were determined using a micromethod modified from that of Pang and co-workers. 17-alpha-Hydroxyprogesterone 0-18 contactin 3 Homo sapiens 84-88 6458518-4 1981 In the combined population (male, female, and females on oral contraceptives) DHEAS was correlated with TFI (0.56**), T (0.54**), %FT (0.52**), delta 4A (0.40**), and age (-0.40**) with 66 df and 17-P (0.30*) with 54 df. 17-alpha-Hydroxyprogesterone 196-200 sulfotransferase family 2A member 1 Homo sapiens 78-83 6749579-6 1982 Metabolic studies of GnRH-treated cultures revealed that LH-stimulated androsterone and 5 alpha-androstane-3 alpha, 17 beta-diol were decreased by 90%; androstenedione, testosterone and DHEA were decreased by 70%; 17 alpha-hydroxypregnenolone and 17 alpha-hydroxyprogesterone were decreased by 50%; pregnenolone was unchanged; and progesterone was increased 40%. 17-alpha-Hydroxyprogesterone 247-275 gonadotropin releasing hormone 1 Rattus norvegicus 21-25 6955813-3 1982 On addition of hCG, incorporation of label into progesterone, 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone was remarkably increased. 17-alpha-Hydroxyprogesterone 95-123 chorionic gonadotropin subunit beta 5 Homo sapiens 15-18 6955813-7 1982 When PGF2 alpha or PGE2 were used at the same time as hCG, the increase of progesterone, 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone induced by hCG was reduced by both PGs in a dose dependent manner. 17-alpha-Hydroxyprogesterone 125-150 chorionic gonadotropin subunit beta 5 Homo sapiens 54-57 6955813-7 1982 When PGF2 alpha or PGE2 were used at the same time as hCG, the increase of progesterone, 20 alpha-dihydroprogesterone and 17 alpha-hydroxyprogesterone induced by hCG was reduced by both PGs in a dose dependent manner. 17-alpha-Hydroxyprogesterone 125-150 chorionic gonadotropin subunit beta 5 Homo sapiens 162-165 7078165-6 1982 Testicular steroidogenesis responded rapidly to hCG stimulation, which was reflected in elevated spermatic vein levels of pregnenolone, progesterone, 17-hydroxyprogesterone, androstenedione, testosterone and 5 alpha-dihydrotestosterone at 30 min following hCG. 17-alpha-Hydroxyprogesterone 150-172 chorionic gonadotropin subunit beta 5 Homo sapiens 48-51 7078165-8 1982 Four days following hCG administration, the peripheral serum concentrations of 17-hydroxyprogesterone, testosterone, 5 alpha-dihydrotestosterone and estradiol were significantly increased. 17-alpha-Hydroxyprogesterone 79-101 chorionic gonadotropin subunit beta 5 Homo sapiens 20-23 6274570-12 1981 ACTH produced increases in plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, aldosterone, 17 alpha-hydroxyprogesterone and 17 alpha,20 alpha-dihydroxyprogesterone. 17-alpha-Hydroxyprogesterone 112-140 proopiomelanocortin Homo sapiens 0-4 6254362-8 1980 Of seven family members tested, two fathers and one mother had an intermediate 17OHP response to ACTH, thus suggesting heterozygosity. 17-alpha-Hydroxyprogesterone 79-84 proopiomelanocortin Homo sapiens 97-101 6271801-4 1981 The ACTH-stimulated levels of 17-hydroxyprogesterone and delta 4-androstenedione in the cryptic family members were elevated above the level of the general population or family members heterozygous for classical CAH, but below that of patients with CAH. 17-alpha-Hydroxyprogesterone 30-52 cripto, FRL-1, cryptic family 1 Homo sapiens 88-95 7317012-6 1981 Ovarian lipase activity in lactating rats was positively correlated with the serum concentrations of progesterone and of 20 alpha-hydroxyprogesterone and negatively correlated with the high-density-lipoprotein non-esterified cholesterol concentration. 17-alpha-Hydroxyprogesterone 124-149 lipase G, endothelial type Rattus norvegicus 8-14 6254362-4 1980 A single intravenous bolus of 0.25 mg of adrenocorticotropic hormone (ACTH) caused much larger increased in 17OHP in all five CAH patients than in the control and hirsute women. 17-alpha-Hydroxyprogesterone 108-113 proopiomelanocortin Homo sapiens 41-68 6254362-4 1980 A single intravenous bolus of 0.25 mg of adrenocorticotropic hormone (ACTH) caused much larger increased in 17OHP in all five CAH patients than in the control and hirsute women. 17-alpha-Hydroxyprogesterone 108-113 proopiomelanocortin Homo sapiens 70-74 6257501-5 1981 After 2 days of estradiol treatment, the maximum hCG stimulation of androstenedione, testosterone, 17 alpha-hydroxypregnenolone, and 17 alpha-hydroxyprogesterone production by ovarian cells was inhibited by 90%; pregnenolone production was unchanged, while progesterone production was increased by 30%. 17-alpha-Hydroxyprogesterone 133-161 chorionic gonadotropin subunit beta 5 Homo sapiens 49-52 7419679-1 1980 Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). 17-alpha-Hydroxyprogesterone 97-125 hypertrichosis 2 (generalised, congenital) Homo sapiens 40-43 7419679-1 1980 Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). 17-alpha-Hydroxyprogesterone 127-133 hypertrichosis 2 (generalised, congenital) Homo sapiens 40-43 7419679-1 1980 Intramuscular administration of 1500 IU hCG daily for 3 days induced a transient accumulation of 17 alpha-hydroxyprogesterone (17 OHP) relative to testosterone (T) in normal men, reaching its maximum 24 h after the first injection (17 OHP to T ratio, 1.7 +/- 0.3 times baseline; P < 0.01). 17-alpha-Hydroxyprogesterone 232-238 hypertrichosis 2 (generalised, congenital) Homo sapiens 40-43 6253614-0 1980 Detection of heterozygotes for congenital adrenal hyperplasia: 21-hydroxylase deficiency-a comparison of HLA typing and 17-OH progesterone response to ACTH infusion. 17-alpha-Hydroxyprogesterone 120-138 proopiomelanocortin Homo sapiens 151-155 7419679-2 1980 Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). 17-alpha-Hydroxyprogesterone 175-181 hypertrichosis 2 (generalised, congenital) Homo sapiens 31-34 6253614-4 1980 When the 17-OHP response to ACTH and the HLA haplotypes of parents and unaffected siblings were compared, there was a 79% concordance for identification of heterozygotes. 17-alpha-Hydroxyprogesterone 9-15 proopiomelanocortin Homo sapiens 28-32 7419679-2 1980 Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). 17-alpha-Hydroxyprogesterone 175-181 hypertrichosis 2 (generalised, congenital) Homo sapiens 125-128 7419679-2 1980 Simultaneous administration of hCG and the estrogen antagonist tamoxifen (20 mg twice daily) almost completely abolished the hCG-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hCG alone). 17-alpha-Hydroxyprogesterone 175-181 hypertrichosis 2 (generalised, congenital) Homo sapiens 125-128 6258552-3 1980 One of the siblings possessed only one of the relevant haplotypes, and was shown to be heterozygous for 21-OH deficiency by the 17 alpha hydroxyprogesterone response to ACTH stimulation. 17-alpha-Hydroxyprogesterone 128-156 proopiomelanocortin Homo sapiens 169-173 6986393-5 1980 An inverse relationship was found between insulin binding to monocytes and levels of 17 beta-estradiol, progesterone, and 17 alpha-hydroxyprogesterone; this relationship was not observed in insulin binding to erythrocytes. 17-alpha-Hydroxyprogesterone 122-150 insulin Homo sapiens 42-49 6768759-1 1980 Single im administration of 1500 IU hCG evoked a biphasic response of 17-hydroxyprogesterone (17-OHP) and testosterone (T) in six eugonadotropic men, with an early peak after 4 h, a nadir at 5 h, and a second peak 24 and 72 h after hCG loading, respectively. 17-alpha-Hydroxyprogesterone 70-92 chorionic gonadotropin subunit beta 5 Homo sapiens 36-39 6768759-1 1980 Single im administration of 1500 IU hCG evoked a biphasic response of 17-hydroxyprogesterone (17-OHP) and testosterone (T) in six eugonadotropic men, with an early peak after 4 h, a nadir at 5 h, and a second peak 24 and 72 h after hCG loading, respectively. 17-alpha-Hydroxyprogesterone 94-100 chorionic gonadotropin subunit beta 5 Homo sapiens 36-39 6768759-4 1980 In the normal men, the 17-OHP rise was more pronounced than the T increase, and thus, from 4 h on, a gradually rising 17-OHP to T ratio was observed, which reached its maximum 24 h after the hCG injection. 17-alpha-Hydroxyprogesterone 23-29 chorionic gonadotropin subunit beta 5 Homo sapiens 191-194 6249834-5 1980 The basal tests were often insufficient to show the accumulation of the precursors (especially 17-hydroxyprogesterone) which are often given as evidence for an increase in ACTH stimulation. 17-alpha-Hydroxyprogesterone 95-117 proopiomelanocortin Homo sapiens 172-176 6768759-4 1980 In the normal men, the 17-OHP rise was more pronounced than the T increase, and thus, from 4 h on, a gradually rising 17-OHP to T ratio was observed, which reached its maximum 24 h after the hCG injection. 17-alpha-Hydroxyprogesterone 118-124 chorionic gonadotropin subunit beta 5 Homo sapiens 191-194 6768759-5 1980 In contrast, in the hypogonadotropic patients, the 17-OHP to T ratio did not rise but rather decreased to minimal values 72 h after hCG loading. 17-alpha-Hydroxyprogesterone 51-57 chorionic gonadotropin subunit beta 5 Homo sapiens 132-135 6768759-6 1980 These data suggest that in normal men, but not in hypogonadotropic patients, hCG may rapidly modify steroidogenesis by temporarily depressing the conversion of 17-OHP to T. 17-alpha-Hydroxyprogesterone 160-166 chorionic gonadotropin subunit beta 5 Homo sapiens 77-80 121057-6 1979 The NADPH-cytochrome P-450 reductase was capable of reconstituting the 21-hydroxylase activity of 17 alpha-hydroxyprogesterone in the presence of cytochrome P-45021 of adrenocortical microsomes. 17-alpha-Hydroxyprogesterone 101-126 cytochrome p450 oxidoreductase Bos taurus 4-36 7350181-1 1980 After both single (1500 IU) and daily repeated (1500 IU daily for 3 days) im administration of hCG, peak values of 17-hydroxyprogesterone (17OHP) were achieved 24 h after the single or first injection, whereas plasma testosterone (T) levels reached their maximum 48 h later. 17-alpha-Hydroxyprogesterone 115-137 hypertrichosis 2 (generalised, congenital) Homo sapiens 95-98 7350181-1 1980 After both single (1500 IU) and daily repeated (1500 IU daily for 3 days) im administration of hCG, peak values of 17-hydroxyprogesterone (17OHP) were achieved 24 h after the single or first injection, whereas plasma testosterone (T) levels reached their maximum 48 h later. 17-alpha-Hydroxyprogesterone 139-144 hypertrichosis 2 (generalised, congenital) Homo sapiens 95-98 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 69-75 hypertrichosis 2 (generalised, congenital) Homo sapiens 32-35 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 69-75 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 69-75 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 157-163 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 157-163 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 157-163 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 7350181-3 1980 In both the single and repeated hCG experiments, the initial rise of 17-OHP was more pronounced than that of T, leading to a steep temporary increase of the 17-OHP to T ratio in the first 24 h. Repeated hCG administration for 3 days to the same subjects elicited T responses at 48 and 72 h quantitatively similar to those produced by single hCG loading, although the 17-OHP response appeared slightly higher in the multiple dose experiment. 17-alpha-Hydroxyprogesterone 157-163 hypertrichosis 2 (generalised, congenital) Homo sapiens 203-206 225351-6 1979 In contrast, serum 17alpha-hydroxyprogesterone increased 12-fold to 5.5+/-0.5 ng/ml at day 1 and was increased fourfold during the subsequent 3 d. The LH-receptor binding capacity of the primate testis was reduced by 18.3+/-6.0% on day 1, 51.7+/-7.4% on day 2, and 45.3+/-2.4% on day 4. 17-alpha-Hydroxyprogesterone 19-46 luteinizing hormone/choriogonadotropin receptor Homo sapiens 151-162 222097-5 1979 Following ACTH stimulation, the increase of 17-OH-P was significantly higher in CAH-heterozygotes than in controls in both tests (P less than 0.0005). 17-alpha-Hydroxyprogesterone 44-51 proopiomelanocortin Homo sapiens 10-14 222097-6 1979 Heterozygotes were characterized by a 17-OH-P increase after ACTH stimulation exceeding the + 2 SD limit of the 17-OH-P increase found in controls. 17-alpha-Hydroxyprogesterone 38-45 proopiomelanocortin Homo sapiens 61-65 263344-4 1978 Administration of hCG for 3 days raised plasma testosterone and 17-OHP levels in both groups. 17-alpha-Hydroxyprogesterone 64-70 chorionic gonadotropin subunit beta 5 Homo sapiens 18-21 371321-11 1979 Serum levels of oestradiol, 17-hydroxyprogesterone and progesterone significantly increased in response to the elevated serum gonadotrophin levels after LH-RH stimulation during the 4 h test period, but the rise did not correlate to the LH-RH dose used. 17-alpha-Hydroxyprogesterone 28-50 gonadotropin releasing hormone 1 Homo sapiens 153-158 455752-0 1979 [Determination of serum 17 alpha hydroxyprogesterone with 17 alpha-hydroxyprogesterone radioimmunoassay-kit (CIS) (author"s transl)]. 17-alpha-Hydroxyprogesterone 24-52 cytokine inducible SH2 containing protein Homo sapiens 109-112 455752-0 1979 [Determination of serum 17 alpha hydroxyprogesterone with 17 alpha-hydroxyprogesterone radioimmunoassay-kit (CIS) (author"s transl)]. 17-alpha-Hydroxyprogesterone 58-86 cytokine inducible SH2 containing protein Homo sapiens 109-112 422695-2 1979 C21 steroids: progesterone, 16 alpha-hydroxyprogesterone, 17 alpha-hydroxyprogesterone, 20 alpha-dihydroprogesterone, delta 5-pregnenolone, delta 5-pregnenolone sulfate, and 17-hydroxy delta 5-pregnenolone. 17-alpha-Hydroxyprogesterone 31-56 TBL1X/Y related 1 Homo sapiens 0-3 578062-4 1977 The deficient cortisol production coupled with the presence of unusual intermediates such as Reichstein"s compound S and 21-deoxycortisol can be explained by a shift in the substrate specificity of 11beta-hydroxylase from C-21-hydroxylated substrates (i.e. compound S) to C-21-deoxy substrates (i.e. 17-hydroxyprogesterone). 17-alpha-Hydroxyprogesterone 300-322 TBL1X/Y related 1 Homo sapiens 222-226 233672-11 1978 Thus, under the influence of endogenous ACTH which is moderately increased, 17-OHP concentrations far exceed normal values, whereas plasma testosterone seems to be unaffected. 17-alpha-Hydroxyprogesterone 76-82 proopiomelanocortin Homo sapiens 40-44 573768-3 1978 No significant differences were found between baseline levels of 17-OHP, delta, DHEA, DHEAS, A-diol, and F. After hCG stimulation between T, DHT, E2 and 17-OHP levels showed a significant increase in the two groups of subjects. 17-alpha-Hydroxyprogesterone 153-159 hypertrichosis 2 (generalised, congenital) Homo sapiens 114-117 578062-4 1977 The deficient cortisol production coupled with the presence of unusual intermediates such as Reichstein"s compound S and 21-deoxycortisol can be explained by a shift in the substrate specificity of 11beta-hydroxylase from C-21-hydroxylated substrates (i.e. compound S) to C-21-deoxy substrates (i.e. 17-hydroxyprogesterone). 17-alpha-Hydroxyprogesterone 300-322 TBL1X/Y related 1 Homo sapiens 272-276 4156833-6 1974 The induction of ornithine decarboxylase produced by dexamethasone was inhibited by 17alpha-hydroxy-progesterone; this compound also blocked the induction of ornithine decarboxylase in livers of partially hepatectomized rats. 17-alpha-Hydroxyprogesterone 84-112 ornithine decarboxylase 1 Rattus norvegicus 17-40 879203-8 1977 of HCG completely prevented the ability of HCG to maintain serum levels of 17-OHP. 17-alpha-Hydroxyprogesterone 75-81 chorionic gonadotropin subunit beta 5 Homo sapiens 3-6 879203-8 1977 of HCG completely prevented the ability of HCG to maintain serum levels of 17-OHP. 17-alpha-Hydroxyprogesterone 75-81 chorionic gonadotropin subunit beta 5 Homo sapiens 43-46 192874-2 1977 The baseline and poststimulation concentrations of hormones (of each group) were similar except for those of 17-OHP in the parents which were significantly greater following administration of ACTH. 17-alpha-Hydroxyprogesterone 109-115 proopiomelanocortin Homo sapiens 192-196 190255-4 1977 Following injection of 10 U of crystalline ACTH into the testicular artery; testicular vein concentrations of 17-OHP, delta and T increased to 729 mug/dl, 2,390 mug/dl and 9,660 ng/dl respectively. 17-alpha-Hydroxyprogesterone 110-116 proopiomelanocortin Homo sapiens 43-47 206181-1 1977 The C19 and C21 urinary steroids from a virilizing adrenal tumour with high levels of plasma 17 alpha-hydroxyprogesterone and its urinary metabolites have been identified and quantitated gas chromatography and mass spectrometry of sephadex fractions of the total urinary extract. 17-alpha-Hydroxyprogesterone 93-121 TBL1X/Y related 1 Homo sapiens 12-15 5267-2 1976 The average Km for NADPH in the 21-hydroxylation of progesterone is 10.4 muM while that for the 21-hydroxylation of 17-hydroxyprogesterone is 0.6 muM. 17-alpha-Hydroxyprogesterone 116-138 latexin Homo sapiens 146-149 169282-1 1975 Concentrations of 17-hydroxyprogesterone are significantly greater in heterozygous carriers of CVAH than in controls 30 and 60 minutes after an infusion of 25 units of synthetic ACTH 1-24 and 2 hours after beginning a 4-hour infusion of 50 units ACTH. 17-alpha-Hydroxyprogesterone 18-40 proopiomelanocortin Homo sapiens 178-182 169282-1 1975 Concentrations of 17-hydroxyprogesterone are significantly greater in heterozygous carriers of CVAH than in controls 30 and 60 minutes after an infusion of 25 units of synthetic ACTH 1-24 and 2 hours after beginning a 4-hour infusion of 50 units ACTH. 17-alpha-Hydroxyprogesterone 18-40 proopiomelanocortin Homo sapiens 246-250 166091-9 1975 Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. 17-alpha-Hydroxyprogesterone 130-153 proopiomelanocortin Homo sapiens 66-70 166091-9 1975 Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. 17-alpha-Hydroxyprogesterone 155-161 proopiomelanocortin Homo sapiens 66-70 166091-9 1975 Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. 17-alpha-Hydroxyprogesterone 155-161 proopiomelanocortin Homo sapiens 175-179 166091-9 1975 Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. 17-alpha-Hydroxyprogesterone 192-198 proopiomelanocortin Homo sapiens 66-70 166091-9 1975 Seven of the 9 hiruste women who had an exaggerated A response to ACTH had a normal maximum F response, but a greater than normal 17-hydroxy-progesterone (17-OHP) response to ACTH with a high 17-OHP to F ratio, suggesting they have a mild but compensated reduction in 21-hydroxylase or 11beta-hydroxylase activity. 17-alpha-Hydroxyprogesterone 192-198 proopiomelanocortin Homo sapiens 175-179 849732-6 1977 Addition of 200 IU of human chorionic gonadotropin (hCG) in vitro to normal basal zone placentae sharply increased the production of progesterone, 17alpha-hydroxyprogesterone, androstenedione and 5alpha-pregnane-3,20-dione. 17-alpha-Hydroxyprogesterone 147-174 hypertrichosis 2 (generalised, congenital) Homo sapiens 52-55 1271137-6 1976 Even slightly inadequate mineralocorticoid therapy (shown by high plasma renin activity with normal serum electrolytes) was associated with elevated 17OH-progesterone (to 65,000 ng/dl) in spite of usually effective doses of cortisol. 17-alpha-Hydroxyprogesterone 149-166 renin Homo sapiens 73-78 4305376-6 1969 The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. 17-alpha-Hydroxyprogesterone 62-68 proopiomelanocortin Homo sapiens 122-126 33755348-6 2021 The concentrations of 17-OHP (pre- and post-ACTH stimulation) were found to be elevated. 17-alpha-Hydroxyprogesterone 22-28 proopiomelanocortin Canis lupus familiaris 44-48 33722706-8 2021 Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites. 17-alpha-Hydroxyprogesterone 85-112 estradiol 17-beta-dehydrogenase 12-B-like L homeolog Xenopus laevis 5-12 33722706-8 2021 Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites. 17-alpha-Hydroxyprogesterone 85-112 estradiol 17-beta-dehydrogenase 12-B-like L homeolog Xenopus laevis 19-26 33722706-8 2021 Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites. 17-alpha-Hydroxyprogesterone 85-112 estradiol 17-beta-dehydrogenase 12-B-like L homeolog Xenopus laevis 19-26 33459528-6 2021 IL-18 increased 17-hydroxyprogesterone (17OHP4) and androstenedione (A2) secretion with up-regulation of key steroidogenesis-related genes CYP11A1 and CYP17A1 (P < .05). 17-alpha-Hydroxyprogesterone 16-38 interleukin 18 Bos taurus 0-5 33260786-9 2020 Multivariate linear-regression analysis showed that body fat percentage and HOMA-IR were inversely associated with 17-OH progesterone levels, while FT and ACTH were positively linked to circulating 17-OH progesterone levels. 17-alpha-Hydroxyprogesterone 198-216 proopiomelanocortin Homo sapiens 155-159 33260786-11 2020 Body fat percentage and insulin resistance were negatively related to 17-OH progesterone levels, whereas FT and ACTH levels were positively associated with 17-OH progesterone levels. 17-alpha-Hydroxyprogesterone 70-88 insulin Homo sapiens 24-31 33260786-11 2020 Body fat percentage and insulin resistance were negatively related to 17-OH progesterone levels, whereas FT and ACTH levels were positively associated with 17-OH progesterone levels. 17-alpha-Hydroxyprogesterone 156-174 proopiomelanocortin Homo sapiens 112-116 32510471-0 2020 Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor. 17-alpha-Hydroxyprogesterone 26-48 nuclear receptor subfamily 3, group C, member 1 Mus musculus 94-117 32319048-7 2020 RESULTS: GnRH analogue significantly stimulated plasma LH, FSH, 17-OHP and estradiol secretion (p from < 0.05 to < 0.001 vs basal levels), whereas no effect was observed on both serum AMH and VitD concentrations in all groups. 17-alpha-Hydroxyprogesterone 64-70 gonadotropin releasing hormone 1 Homo sapiens 9-13 32236851-5 2020 Immunoassays revealed higher baseline 17OHP and testosterone, and after ACTH stimulation, higher 17OHP (17OHP60) and lower cortisol, whereas LC-MS/MS revealed higher 17OHP (17OHPLC-MS/MS), progesterone and 21-deoxycortisol and lower corticosterone in 21-NCAH compared with both 21-HTZ and PCOS patients. 17-alpha-Hydroxyprogesterone 97-102 proopiomelanocortin Homo sapiens 72-76 32236851-5 2020 Immunoassays revealed higher baseline 17OHP and testosterone, and after ACTH stimulation, higher 17OHP (17OHP60) and lower cortisol, whereas LC-MS/MS revealed higher 17OHP (17OHPLC-MS/MS), progesterone and 21-deoxycortisol and lower corticosterone in 21-NCAH compared with both 21-HTZ and PCOS patients. 17-alpha-Hydroxyprogesterone 97-102 proopiomelanocortin Homo sapiens 72-76 32838438-1 2021 BACKGROUND: Mutations of CYP21A2 encoding 21-hydroxylase are the most frequent cause of congenital adrenal hyperplasia (CAH) and are associated either with elevated basal or ACTH-stimulated levels of 17-hydroxyprogesterone (17OHP) in blood. 17-alpha-Hydroxyprogesterone 200-222 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 25-32 32838438-1 2021 BACKGROUND: Mutations of CYP21A2 encoding 21-hydroxylase are the most frequent cause of congenital adrenal hyperplasia (CAH) and are associated either with elevated basal or ACTH-stimulated levels of 17-hydroxyprogesterone (17OHP) in blood. 17-alpha-Hydroxyprogesterone 224-229 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 25-32 32647925-20 2020 The 17OHP levels (basal and after ACTH) in the standard ACTH stimulation test were highest in group C1 and also significantly higher in group C2 as in C3, the ACTH-stimulated cortisol levels (ng/ml) were significantly lower in groups C1 (192.1 +- 62.5) and C2 (218 +- 50) than in C3 (297.3 +- 98.7). 17-alpha-Hydroxyprogesterone 4-9 proopiomelanocortin Homo sapiens 34-38 32647925-20 2020 The 17OHP levels (basal and after ACTH) in the standard ACTH stimulation test were highest in group C1 and also significantly higher in group C2 as in C3, the ACTH-stimulated cortisol levels (ng/ml) were significantly lower in groups C1 (192.1 +- 62.5) and C2 (218 +- 50) than in C3 (297.3 +- 98.7). 17-alpha-Hydroxyprogesterone 4-9 proopiomelanocortin Homo sapiens 56-60 32647925-20 2020 The 17OHP levels (basal and after ACTH) in the standard ACTH stimulation test were highest in group C1 and also significantly higher in group C2 as in C3, the ACTH-stimulated cortisol levels (ng/ml) were significantly lower in groups C1 (192.1 +- 62.5) and C2 (218 +- 50) than in C3 (297.3 +- 98.7). 17-alpha-Hydroxyprogesterone 4-9 proopiomelanocortin Homo sapiens 56-60 32510471-3 2020 Here, we show that 17-hydroxyprogesterone (17-OHP), an intermediate steroid in the biosynthetic pathway that converts cholesterol to cortisol, binds to and stimulates the transcriptional activity of GR. 17-alpha-Hydroxyprogesterone 19-41 nuclear receptor subfamily 3, group C, member 1 Mus musculus 199-201 32510471-3 2020 Here, we show that 17-hydroxyprogesterone (17-OHP), an intermediate steroid in the biosynthetic pathway that converts cholesterol to cortisol, binds to and stimulates the transcriptional activity of GR. 17-alpha-Hydroxyprogesterone 43-49 nuclear receptor subfamily 3, group C, member 1 Mus musculus 199-201 32510471-4 2020 Hepatic 17-OHP concentrations are increased in diabetic mice and patients due to aberrantly increased expression of Cyp17A1. 17-alpha-Hydroxyprogesterone 8-14 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 116-123 32510471-6 2020 Therefore, our results identify a Cyp17A1/17-OHP/GR-dependent pathway in the liver that mediates obesity-induced hyperglycemia, suggesting that selectively targeting hepatic Cyp17A1 may provide a therapeutic avenue for treating T2DM. 17-alpha-Hydroxyprogesterone 42-48 nuclear receptor subfamily 3, group C, member 1 Mus musculus 49-51 32510471-6 2020 Therefore, our results identify a Cyp17A1/17-OHP/GR-dependent pathway in the liver that mediates obesity-induced hyperglycemia, suggesting that selectively targeting hepatic Cyp17A1 may provide a therapeutic avenue for treating T2DM. 17-alpha-Hydroxyprogesterone 42-48 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 174-181 31982399-4 2020 17beta-HSD12 (presumably orthologous to salmon 17beta-HSD12L) has been detected in Nile tilapia; however, its enzymatic activity and specific ability to convert the DHP substrate 17alpha-hydroxyprogesterone (17OHP) have not been examined. 17-alpha-Hydroxyprogesterone 179-206 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 0-12 31982399-4 2020 17beta-HSD12 (presumably orthologous to salmon 17beta-HSD12L) has been detected in Nile tilapia; however, its enzymatic activity and specific ability to convert the DHP substrate 17alpha-hydroxyprogesterone (17OHP) have not been examined. 17-alpha-Hydroxyprogesterone 208-213 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 0-12 31982399-7 2020 HEK293T cells transfected with hsd17b12 exhibited a strong ability to convert exogenous 17OHP to DHP (73.8% yield). 17-alpha-Hydroxyprogesterone 88-93 hydroxysteroid 17-beta dehydrogenase 12 Homo sapiens 31-39 32242900-13 2020 Low-normal serum estradiol (E2) and testosterone levels contrasted with chronically increased serum P and 17-OHP levels, which further increased after adrenocorticotrophic hormone (ACTH) administration. 17-alpha-Hydroxyprogesterone 106-112 proopiomelanocortin Homo sapiens 181-185 32007561-3 2020 Increased CYP17A1 activity in endocrine disorders and diseases are associated with elevated C21 and C19 steroids which include 17alpha-hydroxyprogesterone and androgens, as well as C11-oxy C21 and C11-oxy C19 steroids. 17-alpha-Hydroxyprogesterone 127-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 10-17 32521918-7 2020 FGF-2 and HGF were found to decrease the intracellular levels of 17-OH progesterone in both cell lines, whereas HGF alone was found to increase the intracellular levels of DHT only in PC3 cells. 17-alpha-Hydroxyprogesterone 65-83 fibroblast growth factor 2 Homo sapiens 0-5 32521918-7 2020 FGF-2 and HGF were found to decrease the intracellular levels of 17-OH progesterone in both cell lines, whereas HGF alone was found to increase the intracellular levels of DHT only in PC3 cells. 17-alpha-Hydroxyprogesterone 65-83 hepatocyte growth factor Homo sapiens 10-13 31201927-10 2019 Due to the increase of CBG synthesis, cortisol levels were increased under oral contraceptives (OC) significantly (p < 0.0001), while OC suppressed progesterone, 17-OHP, androstenedione, and estradiol (p < 0.0001). 17-alpha-Hydroxyprogesterone 165-171 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 23-26 31090904-7 2019 The GR was activated with comparable potency to cortisol by corticosterone and 21-deoxycortisol or with 4-100x lower potency by 11-hydroxyprogesterone, 11-deoxycortisol, aldosterone, 11-deoxycorticosterone, progesterone, and 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 225-247 nuclear receptor subfamily 3 group C member 1 Homo sapiens 4-6 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). 17-alpha-Hydroxyprogesterone 149-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 0-20 31509771-1 2019 Cytochrome P450 17A1 (CYP17A1) catalyses the 17alpha-hydroxylation and 17,20 lyase reactions to convert pregnenolone to 17alpha-hydroxypregnenolone (17OHP) and subsequently the androgen dehydroepiandrosterone (DHEA). 17-alpha-Hydroxyprogesterone 149-154 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 22-29 30468857-6 2019 It was also demonstrated that the affinity of CYB5A/CYP17A1 interaction increased in the presence of two other steroidal substrates 17alpha-hydroxyprogesterone and pregnenolone and that effect was comparable with P4. 17-alpha-Hydroxyprogesterone 132-159 cytochrome b5 type A Homo sapiens 46-51 31501175-9 2019 Adrenocorticotropic hormone stimulated 17OHP, was elevated confirming the diagnosis of underlying non-classic CAH. 17-alpha-Hydroxyprogesterone 39-44 proopiomelanocortin Homo sapiens 0-27 31158444-9 2019 In addition, the combination of fast LC and MS3 detection enables specific quantitation of 17-OHP from dried blood spots on a screening time scale. 17-alpha-Hydroxyprogesterone 91-97 MS3 Homo sapiens 44-47 31121610-9 2019 Circulating irisin levels correlated with 17-hydroxyprogesterone, testosterone, and insulin. 17-alpha-Hydroxyprogesterone 42-64 fibronectin type III domain containing 5 Homo sapiens 12-18 30468857-6 2019 It was also demonstrated that the affinity of CYB5A/CYP17A1 interaction increased in the presence of two other steroidal substrates 17alpha-hydroxyprogesterone and pregnenolone and that effect was comparable with P4. 17-alpha-Hydroxyprogesterone 132-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 52-59 30241348-3 2018 Pregnenolone, progesterone, 17-OH-pregnenolone, and 17-OH-progesterone increased C21 steroid (5-pregnan-3,20-dione, 5-pregnan-3,17-diol-20-one, 5-pregnan-3-ol-20-one) formation in the backdoor pathway, and demonstrated a trend of stimulating dihydroepiandrosterone or its precursors in the backdoor pathway in LNCaP and 22Rv1 cells. 17-alpha-Hydroxyprogesterone 52-70 TBL1X/Y related 1 Homo sapiens 81-84 30918916-0 2019 Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. 17-alpha-Hydroxyprogesterone 11-33 chorionic gonadotropin subunit beta 5 Homo sapiens 47-50 30918916-2 2019 Objective: To determine whether 17-OHP responses to recombinant-human chorionic gonadotropin (r-hCG) are individually correlated to the size of antral follicles among women with PCOS. 17-alpha-Hydroxyprogesterone 32-38 Rh family C glycoprotein Homo sapiens 52-99 30918916-12 2019 Conclusions: 17-OHP responses to hCG in individuals with PCOS were not correlated to the distribution of antral follicles. 17-alpha-Hydroxyprogesterone 13-19 chorionic gonadotropin subunit beta 5 Homo sapiens 33-36 31256164-6 2019 The effect on CYP21A2 activity was assessed by testing the conversion of radiolabeled 17OHP to 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 86-91 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 14-21 31450227-8 2019 In 21OHD, some of the accumulated intra-adrenal 17OHP is converted to 21-deoxycortisol (21-deoxy) by 11beta-hydroxylase (CYP11B1); 21-deoxy is not elevated in premature infants or in other forms of CAH, and hence is a more specific marker for 21OHD. 17-alpha-Hydroxyprogesterone 48-53 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 121-128 30006291-5 2018 Immunization of mice with 17-OHP-3-(O-carboxymethyl) oxime-bovine serum albumin led to the generation of 15 anti-17-OHP IgG1-and-IgG2b-secreting hybridomas. 17-alpha-Hydroxyprogesterone 26-32 LOC105243590 Mus musculus 120-124 29368340-7 2018 Adolescents with PCOS compared to controls had significantly elevated concentrations of fasting serum irisin (mean +- SD; PCOS, 1.7 +- 1.0 mug/mL vs controls, 1.0 +- 0.4 mug/mL; P = .007), luteinizing hormone (LH), oestradiol, testosterone, Delta4-androstenedione, 17-hydroxyprogesterone, glucose, as well as free androgen index, Ferriman-Gallwey score and mean ovarian volume (MOV). 17-alpha-Hydroxyprogesterone 265-287 fibronectin type III domain containing 5 Homo sapiens 102-108 30113485-11 2018 ACTH-stimulating test revealed a low basal level and low response for cortisol, and a high basal level and low response for 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 124-146 proopiomelanocortin Homo sapiens 0-4 30229581-6 2018 And the activities of 17alpha-hydroxylase and 17,20-lyase of CYP17A1 were evaluated by measuring the conversion of progesterone to 17alpha-hydroxyprogesterone and of 17alpha-hydroxypregnenolone to dehydroepiandrosterone, respectively. 17-alpha-Hydroxyprogesterone 131-158 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 61-68 29758981-0 2018 Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 83-105 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 17-24 29758981-6 2018 Adding to a previous study of PREG and 17-OH PREG metabolism, the current work provides definitive evidence for a more facile protonation of the initially formed ferric peroxo-intermediate for 17-OH PROG-bound CYP17A1, compared to the complex with 17-OH PREG. 17-alpha-Hydroxyprogesterone 193-203 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 210-217 29283561-3 2018 However, the subsequent 17,20 carbon-carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17alpha-hydroxypregnenlone (OHPREG) versus 17alpha-hydroxyprogesterone (OHPROG). 17-alpha-Hydroxyprogesterone 268-295 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 118-125 29031893-6 2017 In a previous report, we demonstrated that 3 progestogens, progesterone, 17-alpha hydroxyprogesterone (17-OHP), and medroxyprogesterone acetate (MPA), each inhibit both TNF-alpha- and thrombin-induced fetal membrane weakening at 2 distinct points of the fetal membrane weakening pathway. 17-alpha-Hydroxyprogesterone 73-101 tumor necrosis factor Homo sapiens 169-178 29694951-3 2018 Furthermore, 17-OHP levels were immeasurable during the ACTH test and after withdrawing hydrocortisone medication. 17-alpha-Hydroxyprogesterone 13-19 proopiomelanocortin Homo sapiens 56-60 28938470-11 2017 Furthermore, Cyp21a2-deficient larvae had a typical steroid profile, with reduced concentrations of cortisol and increased concentrations of 17-hydroxyprogesterone and 21-deoxycortisol. 17-alpha-Hydroxyprogesterone 141-163 cytochrome P450, family 21, subfamily A, polypeptide 2 Danio rerio 13-20 29031893-6 2017 In a previous report, we demonstrated that 3 progestogens, progesterone, 17-alpha hydroxyprogesterone (17-OHP), and medroxyprogesterone acetate (MPA), each inhibit both TNF-alpha- and thrombin-induced fetal membrane weakening at 2 distinct points of the fetal membrane weakening pathway. 17-alpha-Hydroxyprogesterone 73-101 coagulation factor II, thrombin Homo sapiens 184-192 29031893-6 2017 In a previous report, we demonstrated that 3 progestogens, progesterone, 17-alpha hydroxyprogesterone (17-OHP), and medroxyprogesterone acetate (MPA), each inhibit both TNF-alpha- and thrombin-induced fetal membrane weakening at 2 distinct points of the fetal membrane weakening pathway. 17-alpha-Hydroxyprogesterone 103-109 tumor necrosis factor Homo sapiens 169-178 29031893-6 2017 In a previous report, we demonstrated that 3 progestogens, progesterone, 17-alpha hydroxyprogesterone (17-OHP), and medroxyprogesterone acetate (MPA), each inhibit both TNF-alpha- and thrombin-induced fetal membrane weakening at 2 distinct points of the fetal membrane weakening pathway. 17-alpha-Hydroxyprogesterone 103-109 coagulation factor II, thrombin Homo sapiens 184-192 29127765-5 2017 Diagnosis of CAH was later established on the basis of significantly elevated adrenocorticotropic hormone (ACTH) stimulated 17-hydroxyprogesterone (17-OHP) values. 17-alpha-Hydroxyprogesterone 124-146 proopiomelanocortin Homo sapiens 78-105 29127765-5 2017 Diagnosis of CAH was later established on the basis of significantly elevated adrenocorticotropic hormone (ACTH) stimulated 17-hydroxyprogesterone (17-OHP) values. 17-alpha-Hydroxyprogesterone 148-154 proopiomelanocortin Homo sapiens 78-105 28471529-9 2017 In prepubertal girls with PCDH19-FE, by challenging adrenal function with ACTH we disclosed defects in the production of cortisol, pregnenolone sulfate, and 17OH-progesterone, which were not apparent in basal condition. 17-alpha-Hydroxyprogesterone 157-174 protocadherin 19 Homo sapiens 26-32 28539365-1 2017 Cytochrome P450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-deoxycorticosterone and 17alpha-hydroxyprogesterone (17alpha-OH-progesterone) to 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 124-151 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 0-32 28539365-1 2017 Cytochrome P450 (P450, CYP) 21A2 is the major steroid 21-hydroxylase, converting progesterone to 11-deoxycorticosterone and 17alpha-hydroxyprogesterone (17alpha-OH-progesterone) to 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 124-151 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 46-68 28610588-2 2017 Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) by purified steroid 11beta-hydroxylase CYP11B1. 17-alpha-Hydroxyprogesterone 80-102 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 124-150 28610588-2 2017 Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) by purified steroid 11beta-hydroxylase CYP11B1. 17-alpha-Hydroxyprogesterone 80-102 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 151-158 28610588-2 2017 Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) by purified steroid 11beta-hydroxylase CYP11B1. 17-alpha-Hydroxyprogesterone 104-110 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 124-150 28610588-2 2017 Recently, a Japan patent has realized 21-DF production via biotransformation of 17-hydroxyprogesterone (17-OHP) by purified steroid 11beta-hydroxylase CYP11B1. 17-alpha-Hydroxyprogesterone 104-110 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 151-158 28610588-12 2017 CONCLUSIONS: Heterologous CYP11B1 was manipulated to construct E. coli biocatalyst converting 17-OHP to 21-DF. 17-alpha-Hydroxyprogesterone 94-100 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 26-33 28893623-5 2017 Cells were treated with varying concentrations of abiraterone for 24h and CYP21A2 activity was measured using [3H] 17-hydroxyprogesterone as substrate. 17-alpha-Hydroxyprogesterone 115-137 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 74-81 27473350-7 2016 RESULT(S): In women with PCOS increased 17-OHP, androstenedione (A), and DHEA responses during ACTH infusion were comparable to those observed in healthy controls. 17-alpha-Hydroxyprogesterone 40-46 proopiomelanocortin Homo sapiens 95-99 28387522-7 2017 Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone. 17-alpha-Hydroxyprogesterone 295-322 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 94-101 28387522-7 2017 Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone. 17-alpha-Hydroxyprogesterone 295-322 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 112-119 28387522-7 2017 Finally, differences in the hydrogen-bond pattern of the substrates were detected both in the CYP17A1-Cpd I and CYP17A1-POA complexes, with the former found to be more pivotal for the hydroxylation site than the latter, suggesting a possible explanation for the slower conversion of CYP17A1 for 17alpha-hydroxyprogesterone over 17alpha-hydroxypregnenolone. 17-alpha-Hydroxyprogesterone 295-322 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 112-119 28225306-16 2017 ABBREVIATIONS: 17-OHP = 17-alpha-hydroxyprogesterone ACTH = adrenocorticotropic hormone BMI = body mass index CAH = congenital adrenal hyperplasia GH = growth hormone HPA = hypothalamus-pituitary-adrenal PRA = plasma renin activity SDS = standard deviation score SV = simple virilizing SW = salt-wasting. 17-alpha-Hydroxyprogesterone 15-21 proopiomelanocortin Homo sapiens 53-57 28225306-16 2017 ABBREVIATIONS: 17-OHP = 17-alpha-hydroxyprogesterone ACTH = adrenocorticotropic hormone BMI = body mass index CAH = congenital adrenal hyperplasia GH = growth hormone HPA = hypothalamus-pituitary-adrenal PRA = plasma renin activity SDS = standard deviation score SV = simple virilizing SW = salt-wasting. 17-alpha-Hydroxyprogesterone 24-52 proopiomelanocortin Homo sapiens 53-57 27743484-2 2017 METHODS: We retrospectively studied 123 patients with nonclassical congenital adrenal hyperplasia, defined as an adrenocorticotropic hormone-stimulated 17-hydroxyprogesterone level of more than 45 nmol/L. 17-alpha-Hydroxyprogesterone 152-174 proopiomelanocortin Homo sapiens 113-140 28489558-11 2017 Stress factors like pregnancy induced hypertension (PIH), early onset sepsis (EOS), neonatal seizures and birth asphyxia significantly increase the neonatal 17-OHP levels. 17-alpha-Hydroxyprogesterone 157-163 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 52-55 28489558-12 2017 CONCLUSIONS: The levels of 17-OHP in newborns was measured around day 3 of life are very sensitive to the influence of gestational age, birth weight and presence of stress factors like maternal PIH, birth asphyxia, neonatal sepsis and neonatal seizures and should be interpreted cautiously. 17-alpha-Hydroxyprogesterone 27-33 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 194-197 27166718-1 2016 BACKGROUND: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. 17-alpha-Hydroxyprogesterone 65-71 chorionic gonadotropin subunit beta 5 Homo sapiens 115-118 27166718-1 2016 BACKGROUND: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. 17-alpha-Hydroxyprogesterone 65-71 anti-Mullerian hormone Homo sapiens 188-210 27166718-2 2016 The objective of this study was to determine whether adolescents with PCOS exhibit similar variable 17-OHP responsiveness to hCG and whether these responses are correlated to AMH levels. 17-alpha-Hydroxyprogesterone 100-106 chorionic gonadotropin subunit beta 5 Homo sapiens 125-128 27166718-1 2016 BACKGROUND: In adult women with polycystic ovary syndrome (PCOS) 17-OHP responses to human chorionic gonadotropin (hCG) stimulation are highly variable and inversely correlated with serum anti-Mullerian hormone (AMH) levels. 17-alpha-Hydroxyprogesterone 65-71 anti-Mullerian hormone Homo sapiens 212-215 27166718-5 2016 RESULTS: Variable 17-OHP responses to hCG were observed among PCOS girls similar to that observed in adults. 17-alpha-Hydroxyprogesterone 18-24 chorionic gonadotropin subunit beta 5 Homo sapiens 38-41 27166718-8 2016 In adolescent PCOS, 17-OHP responsiveness to hCG is not correlated to AMH. 17-alpha-Hydroxyprogesterone 20-26 chorionic gonadotropin subunit beta 5 Homo sapiens 45-48 27933170-10 2016 17-Hydroxyprogesterone is elevated in CAH and has affinity and biological activity at the progesterone receptor. 17-alpha-Hydroxyprogesterone 0-22 progesterone receptor Homo sapiens 90-111 27188454-8 2016 RESULTS: Progesterone (P), 17-hydroxyprogesterone (17OHP), TS, and estradiol (E2) showed a significant increase (P<0.001) after hCG stimulation in both groups. 17-alpha-Hydroxyprogesterone 27-49 hypertrichosis 2 (generalised, congenital) Homo sapiens 131-134 27188454-8 2016 RESULTS: Progesterone (P), 17-hydroxyprogesterone (17OHP), TS, and estradiol (E2) showed a significant increase (P<0.001) after hCG stimulation in both groups. 17-alpha-Hydroxyprogesterone 51-56 hypertrichosis 2 (generalised, congenital) Homo sapiens 131-134 27238715-12 2016 The dietary supplement alpha-lipoic acid and progestogens (P4, MPA and 17alpha-hydroxyprogesterone) have been shown to inhibit both TNF and Thrombin induced FM weakening. 17-alpha-Hydroxyprogesterone 71-98 tumor necrosis factor Homo sapiens 132-135 27238715-12 2016 The dietary supplement alpha-lipoic acid and progestogens (P4, MPA and 17alpha-hydroxyprogesterone) have been shown to inhibit both TNF and Thrombin induced FM weakening. 17-alpha-Hydroxyprogesterone 71-98 coagulation factor II, thrombin Homo sapiens 140-148 27626911-6 2016 17OH-progesterone may initially be elevated due to placental and peripheral activity of 3beta-HSD I, whereas dehydroepiandrosterone may not be increased. 17-alpha-Hydroxyprogesterone 0-17 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens 88-99 26933879-7 2016 RESULTS: Within the CAH group, CIMT correlated with 17-hydroxyprogesterone (r = 0.48, p < 0.05) and androstenedione (r = 0.46, p < 0.05), and was greater in obese subjects. 17-alpha-Hydroxyprogesterone 52-74 CIMT Homo sapiens 31-35 26070709-6 2015 We examined the effects of progesterone, medroxyprogesterone acetate (MPA) and 17alpha-hydroxyprogesterone (HP) on TNF- and thrombin-induced fetal membrane weakening. 17-alpha-Hydroxyprogesterone 79-106 tumor necrosis factor Homo sapiens 115-118 26070709-6 2015 We examined the effects of progesterone, medroxyprogesterone acetate (MPA) and 17alpha-hydroxyprogesterone (HP) on TNF- and thrombin-induced fetal membrane weakening. 17-alpha-Hydroxyprogesterone 79-106 coagulation factor II, thrombin Homo sapiens 124-132 26070709-6 2015 We examined the effects of progesterone, medroxyprogesterone acetate (MPA) and 17alpha-hydroxyprogesterone (HP) on TNF- and thrombin-induced fetal membrane weakening. 17-alpha-Hydroxyprogesterone 108-110 tumor necrosis factor Homo sapiens 115-118 26070709-6 2015 We examined the effects of progesterone, medroxyprogesterone acetate (MPA) and 17alpha-hydroxyprogesterone (HP) on TNF- and thrombin-induced fetal membrane weakening. 17-alpha-Hydroxyprogesterone 108-110 coagulation factor II, thrombin Homo sapiens 124-132 26070709-12 2015 Pretreatment with progesterone, MPA, or HP inhibited both TNF- and thrombin-induced fetal membrane weakening and also inhibited the induced increase in GM-CSF. 17-alpha-Hydroxyprogesterone 40-42 tumor necrosis factor Homo sapiens 58-61 26070709-12 2015 Pretreatment with progesterone, MPA, or HP inhibited both TNF- and thrombin-induced fetal membrane weakening and also inhibited the induced increase in GM-CSF. 17-alpha-Hydroxyprogesterone 40-42 coagulation factor II, thrombin Homo sapiens 67-75 26070709-12 2015 Pretreatment with progesterone, MPA, or HP inhibited both TNF- and thrombin-induced fetal membrane weakening and also inhibited the induced increase in GM-CSF. 17-alpha-Hydroxyprogesterone 40-42 colony stimulating factor 2 Homo sapiens 152-158 25448736-12 2015 In summary, the steroidogenic cell recycles 3betaHSD2 to catalyze the reactions needed to produce androstenedione, progesterone and 17alpha-hydroxyprogesterone on demand in coordination with the mitochondrial translocase, Tim50. 17-alpha-Hydroxyprogesterone 132-159 translocase of inner mitochondrial membrane 50 Homo sapiens 222-227 26207344-3 2015 We studied the in vitro effects of 17-hydroxyprogesterone (17OHP), progesterone (P), 21-deoxycortisol (21DF), and androstenedione (Delta4) on the human glucocorticoid receptor (hGR). 17-alpha-Hydroxyprogesterone 35-57 nuclear receptor subfamily 3 group C member 1 Homo sapiens 152-175 26500747-4 2015 During follow-up, adrenal hypoplasia congenita (AHC) was suspected given his persistently raised adrenocorticotropic hormone levels, with markedly low 17-OH progesterone and androstenedione levels. 17-alpha-Hydroxyprogesterone 151-169 nuclear receptor subfamily 0 group B member 1 Homo sapiens 48-51 26500747-8 2015 Despite its rarity, AHC should be considered in patients who present with primary adrenal failure, low levels of 17-OH progesterone and hypogonadotropic hypogonadism. 17-alpha-Hydroxyprogesterone 113-131 nuclear receptor subfamily 0 group B member 1 Homo sapiens 20-23 25491105-10 2015 RESULTS: Basal and/or stimulated Testosterone DHEA-S and 17-hydroxyprogesterone (17OHP) were inversely associated with insulin sensitivity (WIBSI) from the beginning of puberty, whereas androstenedione was directly associated with gonadotrophins. 17-alpha-Hydroxyprogesterone 57-79 insulin Homo sapiens 119-126 25491105-10 2015 RESULTS: Basal and/or stimulated Testosterone DHEA-S and 17-hydroxyprogesterone (17OHP) were inversely associated with insulin sensitivity (WIBSI) from the beginning of puberty, whereas androstenedione was directly associated with gonadotrophins. 17-alpha-Hydroxyprogesterone 81-86 insulin Homo sapiens 119-126 25210767-4 2014 RESULTS: The carriers (N = 27) of a well-defined CYP21A2 haplotype cluster (c5) had significantly elevated levels of cortisol (p = 0.0110), and 17-hydroxyprogesterone (p = 0.0001) after ACTH stimulation, and 11-deoxycortisol after metyrapone administration (p = 0.0017), but the hormone values were in normal ranges. 17-alpha-Hydroxyprogesterone 144-166 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 49-56 25896481-0 2015 Influence of 17-Hydroxyprogesterone, Progesterone and Sex Steroids on Mineralocorticoid Receptor Transactivation in Congenital Adrenal Hyperplasia. 17-alpha-Hydroxyprogesterone 13-35 nuclear receptor subfamily 3 group C member 2 Homo sapiens 70-96 25896481-3 2015 Therefore, we analysed the effect of accumulated steroids [17-hydroxyprogesterone (17OHP), progesterone, androstenedione and testosterone] on aldosterone-mediated transactivation of the human mineralocorticoid receptor (hMR). 17-alpha-Hydroxyprogesterone 59-81 nuclear receptor subfamily 3 group C member 2 Homo sapiens 192-218 25896481-3 2015 Therefore, we analysed the effect of accumulated steroids [17-hydroxyprogesterone (17OHP), progesterone, androstenedione and testosterone] on aldosterone-mediated transactivation of the human mineralocorticoid receptor (hMR). 17-alpha-Hydroxyprogesterone 83-88 nuclear receptor subfamily 3 group C member 2 Homo sapiens 192-218 25896481-8 2015 RESULTS: Linear regression analysis showed statistically significant linear inhibition of transactivation of the hMR by 10-10M aldosterone in the presence of increasing 17OHP [F(1,5) = 11.34, p = 0.019] and progesterone [F(1,5) = 11.08, p = 0.021] concentrations. 17-alpha-Hydroxyprogesterone 169-174 mannose receptor C-type 1 Homo sapiens 113-116 25303490-10 2015 RESULTS: Baseline AMH levels in women with PCOS were greater than in normal controls and correlated with levels of LH as well as androstenedione, T, and 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 153-175 anti-Mullerian hormone Homo sapiens 18-21 25313914-10 2015 RESULTS: In women with PCOS, 17-OHP responses were heterogeneous and inversely correlated with AMH and Inh B levels, but not AFC. 17-alpha-Hydroxyprogesterone 29-35 anti-Mullerian hormone Homo sapiens 95-98 25313914-11 2015 In a subgroup of PCOS women with exaggerated 17-OHP responses, AMH levels were equivalent to that of normal women. 17-alpha-Hydroxyprogesterone 45-51 anti-Mullerian hormone Homo sapiens 63-66 25313914-12 2015 In PCOS women with normal 17-OHP responses, AMH levels were markedly elevated. 17-alpha-Hydroxyprogesterone 26-32 anti-Mullerian hormone Homo sapiens 44-47 25313914-13 2015 CONCLUSION: Based on heterogeneous 17-OHP responses to human chorionic gonadotropin in women with PCOS, AMH levels are inversely linked to ovarian androgen production while positively correlated with AFC. 17-alpha-Hydroxyprogesterone 35-41 anti-Mullerian hormone Homo sapiens 104-107 24476082-17 2014 hCG caused a significant rise in 17-OHP in both obese and normal-weight women and an increase in T in obese but not normal-weight women (all P < .04). 17-alpha-Hydroxyprogesterone 33-39 chorionic gonadotropin subunit beta 5 Homo sapiens 0-3 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 179-207 proopiomelanocortin Homo sapiens 65-92 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 179-207 proopiomelanocortin Homo sapiens 94-98 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 209-215 proopiomelanocortin Homo sapiens 65-92 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 209-215 proopiomelanocortin Homo sapiens 94-98 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 250-256 proopiomelanocortin Homo sapiens 65-92 25068307-1 2014 AIM: Aim of the study was to investigate the need to perform the adrenocorticotropic hormone (ACTH) stimulation test by recognizing the importance of a second look at basal serum 17-alpha hydroxyprogesterone (17-OHP) levels and calculating new serum 17-OHP cut-off level. 17-alpha-Hydroxyprogesterone 250-256 proopiomelanocortin Homo sapiens 94-98 25068307-7 2014 When basal serum 17-OHP levels were measured a second time, the need for performing the ACTH stimulation test was decreased. 17-alpha-Hydroxyprogesterone 17-23 proopiomelanocortin Homo sapiens 88-92 25068307-12 2014 Second 17-OHP test reduces the need of performing the ACTH stimulation test by approximately 30%. 17-alpha-Hydroxyprogesterone 7-13 proopiomelanocortin Homo sapiens 54-58 25058354-7 2014 Interestingly, RU486 resulted in a significant CYP21A2 enzymatic blockade as demonstrated by a massive increase in 17-hydroxyprogesterone concentrations in RU486-treated H295R cell supernatants, while cortisol and 11-deoxycortisol secretions were reduced by more than 60%. 17-alpha-Hydroxyprogesterone 115-137 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 47-54 25058354-4 2014 We showed that GR activation, elicited by 48 h exposure to DEX, exerts a global positive regulatory effect on adrenal steroidogenesis as revealed by a 1.5- to 2-fold increase in cortisol, 11-deoxycortisol and 17-hydroxyprogesterone secretion associated with a significant enhanced expression of steroidogenesis factors such as StAR, CYP11A1, CYP21A2 and CYP11B1. 17-alpha-Hydroxyprogesterone 209-231 nuclear receptor subfamily 3 group C member 1 Homo sapiens 15-17 24903198-13 2014 In the patient population prolactin levels were inversely associated with age, smoking status, waist circumference, total cholesterol, triglyceride and low-density lipoprotein (LDL) and positively associated with high-density lipoprotein, estradiol, total testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone and cortisol levels. 17-alpha-Hydroxyprogesterone 302-324 prolactin Homo sapiens 26-35 24903198-14 2014 In multiple regression analyses, prolactin was inversely associated with LDL and positively associated with estradiol, 17-hydroxyprogesterone and cortisol after correcting for age, BMI and smoking status in patients with PCOS. 17-alpha-Hydroxyprogesterone 119-141 prolactin Homo sapiens 33-42 24711560-1 2014 17-Hydroxyprogesterone (17-OHP) is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase. 17-alpha-Hydroxyprogesterone 0-22 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 149-171 24711560-1 2014 17-Hydroxyprogesterone (17-OHP) is an intermediate steroid in the adrenal biosynthetic pathway from cholesterol to cortisol and is the substrate for steroid 21-hydroxylase. 17-alpha-Hydroxyprogesterone 24-30 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 149-171 24667412-5 2014 Our analyses revealed that the residual enzymatic activity of the isolated mutants coding for CYP21A2 aminoacidic substitutions was reduced to a lesser than 50% of the wild type with both progesterone and 17-OH progesterone as substrates. 17-alpha-Hydroxyprogesterone 205-223 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 94-101 23386413-12 2013 Moreover, 17-hydroxyprogesterone values of < 10 ng/ml post-ACTH exclude homozygosity of CYP21A2 mutations. 17-alpha-Hydroxyprogesterone 10-32 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 91-98 24081139-12 2013 To improve this percentage we suggest to perform the CYP21A2 analysis only when 17-OHP after ACTH test is greater than 100 nmol/l. 17-alpha-Hydroxyprogesterone 80-86 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 53-60 23448396-4 2013 RESULTS: A significant hCG dose-dependent incremental increase was found for progesterone (49-160%), 17-OH-progesterone (223-614%), androstenedione (91-340%) and testosterone (95-338%) from Dose 0 to Dose 150, respectively. 17-alpha-Hydroxyprogesterone 101-119 hypertrichosis 2 (generalised, congenital) Homo sapiens 23-26 23448396-9 2013 CONCLUSION: Supplementation with hCG resulted in a clear dose-related response for androgens, progesterone and 17-OH-progesterone. 17-alpha-Hydroxyprogesterone 111-129 hypertrichosis 2 (generalised, congenital) Homo sapiens 33-36 24564598-4 2014 Patients with DAS28>3.2 had lower (p<0.05) total plasma cortisol, 17-hydroxyprogesterone, dehydroepiandrosterone and androstenedione responses in the ACTH test compared to healthy controls. 17-alpha-Hydroxyprogesterone 72-94 proopiomelanocortin Homo sapiens 156-160 23688334-6 2013 GnRH (gonadotropin-releasing hormone)-stimulated peak serum 17OHP (17alpha-hydroxyprogesterone) decreased by 39%. 17-alpha-Hydroxyprogesterone 60-65 gonadotropin releasing hormone 1 Homo sapiens 0-4 23688334-6 2013 GnRH (gonadotropin-releasing hormone)-stimulated peak serum 17OHP (17alpha-hydroxyprogesterone) decreased by 39%. 17-alpha-Hydroxyprogesterone 60-65 gonadotropin releasing hormone 1 Homo sapiens 6-36 23688334-6 2013 GnRH (gonadotropin-releasing hormone)-stimulated peak serum 17OHP (17alpha-hydroxyprogesterone) decreased by 39%. 17-alpha-Hydroxyprogesterone 67-94 gonadotropin releasing hormone 1 Homo sapiens 0-4 23688334-6 2013 GnRH (gonadotropin-releasing hormone)-stimulated peak serum 17OHP (17alpha-hydroxyprogesterone) decreased by 39%. 17-alpha-Hydroxyprogesterone 67-94 gonadotropin releasing hormone 1 Homo sapiens 6-36 23874725-2 2013 Type 2 HSD3B catalyzes the conversion of pregnenolone, 17alpha-hydroxypregnenolone and dehydroepiandrosterone to progesterone, 17alpha-hydroxyprogesterone and androstenedione in the human adrenal cortex and the gonads but the exact regulation of this enzyme is unknown. 17-alpha-Hydroxyprogesterone 127-154 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 Homo sapiens 7-12 23047016-4 2012 Treatment with 17-hydroxyprogesterone (17-OHP) enhanced viability and induced cholesterol efflux, serine and tyrosine phosphorylation, p-Bcl2, p-Akt that are known hallmarks of capacitation in sperm. 17-alpha-Hydroxyprogesterone 15-37 apoptosis regulator Bcl-2 Sus scrofa 137-141 22985688-0 2012 Reverse-hybridization assay for rapid detection of common CYP21A2 mutations in dried blood spots from newborns with elevated 17-OH progesterone. 17-alpha-Hydroxyprogesterone 125-143 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 58-65 22985947-11 2012 CONCLUSION(S): Girls at high risk of developing PCOS display increased adiposity and 17-OHP levels, but are mainly characterized by global insulin resistance and resistance to insulin-induced suppression of lipolysis that were independent of adiposity and 17-OHP levels. 17-alpha-Hydroxyprogesterone 256-262 insulin Homo sapiens 176-183 23047016-4 2012 Treatment with 17-hydroxyprogesterone (17-OHP) enhanced viability and induced cholesterol efflux, serine and tyrosine phosphorylation, p-Bcl2, p-Akt that are known hallmarks of capacitation in sperm. 17-alpha-Hydroxyprogesterone 39-45 apoptosis regulator Bcl-2 Sus scrofa 137-141 23194004-4 2013 RESULTS: AMH levels were higher in untreated PCOS (p < 0.0001), as were luteinizing hormone (LH) (p = 0.0004), testosterone (p = 0.0017) as well as 17-hydroxyprogesterone (p = 0.03). 17-alpha-Hydroxyprogesterone 151-173 anti-Mullerian hormone Homo sapiens 9-12 23377818-0 2013 Serum 17-OH progesterone and free testosterone levels in women patients with Familial Mediterranean Fever: a pivotal study. 17-alpha-Hydroxyprogesterone 6-24 MEFV innate immuity regulator, pyrin Homo sapiens 77-105 23377818-8 2013 A positive correlation was detected between serum levels of 17-OHP and IL-1 beta in FMF patients (p = 0.006; r = 0.486). 17-alpha-Hydroxyprogesterone 60-66 interleukin 1 beta Homo sapiens 71-80 23076844-8 2013 In all women, waist circumference was a negative predictor for ISI; 17-OHP and FAI levels were positive predictors respectively for baseline insulin levels and for 1st PHIS and 2nd PHIS. 17-alpha-Hydroxyprogesterone 68-74 insulin Homo sapiens 141-148 22951291-2 2012 17-OHP is a good substrate for 5alpha-reductase leading to 17alpha-hydroxyallopregnanolone, which is an excellent substrate for the 17,20-lyase activity of CYP17A1. 17-alpha-Hydroxyprogesterone 0-6 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 156-163 22951291-4 2012 The 17,20-lyase activity of CYP17A1 additionally promotes the conversion of 17-OHP and 17alpha-hydroxypregnenolone to androgens in the classical Delta(4) and Delta(5) pathways. 17-alpha-Hydroxyprogesterone 76-82 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 28-35 22910261-5 2012 Prostate specific antigen was 0.2 ng/ml in another patient with notably increased testosterone, androstenedione, dihydrotestosterone and 17-hydroxyprogesterone, and was less than 0.1 ng/ml in the remaining patients. 17-alpha-Hydroxyprogesterone 137-159 kallikrein related peptidase 3 Homo sapiens 0-25 22024430-6 2012 In these species, P450c17 has negligible 17,20-lyase activity with the Delta(4)-steroid 17alpha-hydroxy-progesterone (17OH-P4); therefore androstenedione (A4) is synthesized efficiently only from dehydroepiandrosterone (DHEA) through the Delta(5) pathway. 17-alpha-Hydroxyprogesterone 88-116 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 18-25 23045419-10 2012 Females with premature adrenarche and hyperandrogenemia are likely to bear heterozygous CYP21A2 mutations, therefore systematic evaluation of 17-OHP values in combination with the molecular testing of CYP21A2 gene is beneficial, b. carriers of the mild p.V281L, are at higher risk of androgen excess compared to carriers of other types of mutations. 17-alpha-Hydroxyprogesterone 142-148 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 88-95 22313422-0 2012 Genetic analysis of the CYP21A2 gene in neonatal dried blood spots from children with transiently elevated 17-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 109-131 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 25-32 22930025-7 2012 The 99(th) percentile (p99) of 17OHP in the first sample was 108 nmol/L. 17-alpha-Hydroxyprogesterone 31-36 protein phosphatase 1 regulatory subunit 10 Homo sapiens 23-26 22930025-8 2012 In 13,298 newborns whose weight had been reported, the p99 of 17OHP were, respectively: 344 nmol/L for weight < 1,500 g; 260 nmol/L for weight between 1,500 and 1,999 g; 221 nmol/L for weight between 2,000 and 2,499 g; 109 nmol/L for weight >= 2,500g. 17-alpha-Hydroxyprogesterone 62-67 protein phosphatase 1 regulatory subunit 10 Homo sapiens 55-58 22170725-2 2012 In this backdoor pathway, 17-OHP is converted to 5alpha-pregnane-3alpha,17alpha-diol-20-one (pdiol), which is an excellent substrate for the 17,20 lyase activity of CYP17A1 to produce androsterone. 17-alpha-Hydroxyprogesterone 26-32 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 165-172 22342468-2 2012 The reactions of 17alpha-hydroxyprogesterone with Lawesson"s reagent (LR) in toluene, CH(2)Cl(2) and/or CCl(4) gave, depending on the duration of the reaction, two diastereoisomeric androst-4-en-17-spiro-1,3,2-oxathiaphospholane-2-sulfide pairs 2a,b and 3a,b in approximately 7:3 ratio, differing in configuration at the phosphorus atom. 17-alpha-Hydroxyprogesterone 17-44 C-C motif chemokine ligand 4 Homo sapiens 104-110 22262854-3 2012 In order to understand the structural and molecular basis of this group of diseases, the bovine CYP21A2 crystal structure complexed with the substrate 17-hydroxyprogesterone (17OHP) was determined to 3.0 A resolution. 17-alpha-Hydroxyprogesterone 151-173 steroid 21-hydroxylase Bos taurus 96-103 22262854-3 2012 In order to understand the structural and molecular basis of this group of diseases, the bovine CYP21A2 crystal structure complexed with the substrate 17-hydroxyprogesterone (17OHP) was determined to 3.0 A resolution. 17-alpha-Hydroxyprogesterone 175-180 steroid 21-hydroxylase Bos taurus 96-103 21646284-0 2011 Relationship of CYP21A2 genotype and serum 17-hydroxyprogesterone and cortisol levels in a large cohort of Italian children with premature pubarche. 17-alpha-Hydroxyprogesterone 43-65 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 16-23 21843885-6 2011 MAIN OUTCOME MEASURE(S): Increased basal and adrenocorticotropic hormone (ACTH) stimulated 17alpha-hydroxyprogesterone (17-OHP) values were detected in both partners. 17-alpha-Hydroxyprogesterone 91-118 proopiomelanocortin Homo sapiens 45-72 21843885-6 2011 MAIN OUTCOME MEASURE(S): Increased basal and adrenocorticotropic hormone (ACTH) stimulated 17alpha-hydroxyprogesterone (17-OHP) values were detected in both partners. 17-alpha-Hydroxyprogesterone 120-126 proopiomelanocortin Homo sapiens 45-72 21932247-4 2011 The gene expressions of CYP11A, CYP17, 3beta-HSD2, and CYP19, and hormone productions of PGT, 17-HPT, TTR, ADD, E1, and 17beta-E2 were significantly increased after exposure to F3 extracts from the Daliao River. 17-alpha-Hydroxyprogesterone 94-100 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 24-30 22065901-0 2011 Relationships of basal level of serum 17-hydroxyprogesterone with that of serum androstenedione and their stimulated responses to a low dose of ACTH in young adult patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. 17-alpha-Hydroxyprogesterone 38-60 proopiomelanocortin Homo sapiens 144-148 21586896-9 2011 In the multiple regression analysis INSL3 persisted significantly correlated only with 17OH-progesterone response to buserelin. 17-alpha-Hydroxyprogesterone 87-104 insulin like 3 Homo sapiens 36-41 21646284-2 2011 The aim of this study was to assess the relationship between the CYP21A2 genotype and baseline and ACTH-stimulated 17-hydroxyprogesterone (17-OHP) and cortisol serum levels in patients presenting with PP. 17-alpha-Hydroxyprogesterone 115-137 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 65-72 21646284-2 2011 The aim of this study was to assess the relationship between the CYP21A2 genotype and baseline and ACTH-stimulated 17-hydroxyprogesterone (17-OHP) and cortisol serum levels in patients presenting with PP. 17-alpha-Hydroxyprogesterone 139-145 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 65-72 21646391-3 2011 In this study, we show that the increase in steroidal response is associated with enhanced expression of Cyp17a1, Hsd17b, and Cyp19a1, which encode the enzymes catalyzing the synthesis of 17-OHP(4), testosterone, and E(2) respectively. 17-alpha-Hydroxyprogesterone 188-194 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 105-112 21646391-3 2011 In this study, we show that the increase in steroidal response is associated with enhanced expression of Cyp17a1, Hsd17b, and Cyp19a1, which encode the enzymes catalyzing the synthesis of 17-OHP(4), testosterone, and E(2) respectively. 17-alpha-Hydroxyprogesterone 188-194 cytochrome P450, family 19, subfamily a, polypeptide 1 Mus musculus 126-133 21646391-9 2011 These results indicate that an excess of NGF in the ovary promotes steroidogenesis by enhancing the expression of enzyme genes involved in 17-OHP(4), testosterone, and E(2) synthesis, and causes GC apoptosis by activating a TNF/ STMN1-mediated cell death pathway. 17-alpha-Hydroxyprogesterone 139-145 nerve growth factor Mus musculus 41-44 21059865-7 2011 RESULTS: During insulin infusion, ACTH-stimulated 17-OHPREG and 17-OHP were significantly higher than during saline infusion. 17-alpha-Hydroxyprogesterone 50-56 insulin Homo sapiens 16-23 21307141-8 2011 Measurement of 17alpha-hydroxyprogesterone, androstenedione, and their aromatized products in the media further demonstrated CYP17 expression and activity in the human trophoblast. 17-alpha-Hydroxyprogesterone 15-42 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 125-130 21559465-6 2011 Mamld1 knockdown did not influence the concentrations of pregnenolone and progesterone but significantly reduced those of 17-OH pregnenolone, 17-OH progesterone, dehydroepiandrosterone, androstenedione, and testosterone in the culture media. 17-alpha-Hydroxyprogesterone 142-160 mastermind-like domain containing 1 Mus musculus 0-6 21095220-1 2011 The metabolism of progesterone (PROG) by cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17alpha-hydroxyprogesterone (17-OHPROG) and 16alpha-hydroxyprogesterone (16-OHPROG) in humans. 17-alpha-Hydroxyprogesterone 132-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 41-88 21095220-1 2011 The metabolism of progesterone (PROG) by cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17A1) results in the formation of both 17alpha-hydroxyprogesterone (17-OHPROG) and 16alpha-hydroxyprogesterone (16-OHPROG) in humans. 17-alpha-Hydroxyprogesterone 132-159 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 90-97 21059865-7 2011 RESULTS: During insulin infusion, ACTH-stimulated 17-OHPREG and 17-OHP were significantly higher than during saline infusion. 17-alpha-Hydroxyprogesterone 50-56 proopiomelanocortin Homo sapiens 34-38 19745821-7 2009 Administration of 17-OHP attenuated TNF-alpha-induced hypertension and decreased renal ET-1. 17-alpha-Hydroxyprogesterone 18-24 tumor necrosis factor Rattus norvegicus 36-45 21134444-8 2011 The CYP21A2 H365Y mutant exhibited minimal 21-hydroxylase activity to convert 17-hydroxyprogesterone to 11-deoxycortisol or progesterone to 11-deoxycorticosterone. 17-alpha-Hydroxyprogesterone 78-100 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 4-11 21123943-4 2011 In addition, double-knockout mice showed misregulation of genes in the C21 steroid biosynthesis pathway, with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), resulting in elevated serum levels of its enzymatic product 17-hydroxyprogesterone (17-OHP). 17-alpha-Hydroxyprogesterone 256-278 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 130-184 21123943-4 2011 In addition, double-knockout mice showed misregulation of genes in the C21 steroid biosynthesis pathway, with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), resulting in elevated serum levels of its enzymatic product 17-hydroxyprogesterone (17-OHP). 17-alpha-Hydroxyprogesterone 256-278 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 186-193 21123943-4 2011 In addition, double-knockout mice showed misregulation of genes in the C21 steroid biosynthesis pathway, with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), resulting in elevated serum levels of its enzymatic product 17-hydroxyprogesterone (17-OHP). 17-alpha-Hydroxyprogesterone 280-286 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 130-184 21123943-4 2011 In addition, double-knockout mice showed misregulation of genes in the C21 steroid biosynthesis pathway, with strong induction of cytochrome P450, family 17, subfamily a, polypeptide 1 (Cyp17a1), resulting in elevated serum levels of its enzymatic product 17-hydroxyprogesterone (17-OHP). 17-alpha-Hydroxyprogesterone 280-286 cytochrome P450, family 17, subfamily a, polypeptide 1 Mus musculus 186-193 20846292-2 2010 HTZ for classic and nonclassic (NC) forms have basal and ACTH-stimulated values of 17-hydroxyprogesterone (17OHP) that fail to discriminate them from the general population. 17-alpha-Hydroxyprogesterone 83-105 proopiomelanocortin Homo sapiens 57-61 20846292-2 2010 HTZ for classic and nonclassic (NC) forms have basal and ACTH-stimulated values of 17-hydroxyprogesterone (17OHP) that fail to discriminate them from the general population. 17-alpha-Hydroxyprogesterone 107-112 proopiomelanocortin Homo sapiens 57-61 20110635-6 2010 In 9 patients with a polycystic ovary and hormonal pattern of adrenal hyperandrogenism a significant elevation of adrenocorticotropic hormone (ACTH) stimulated 17-hydroxyprogesterone was detected. 17-alpha-Hydroxyprogesterone 160-182 proopiomelanocortin Homo sapiens 114-141 19733289-5 2009 TNF-alpha and IL-6 increased 2- to 3-fold, respectively, in response to placental ischemia but was normalized in RUPP rats treated with 17 OHP. 17-alpha-Hydroxyprogesterone 136-142 tumor necrosis factor Rattus norvegicus 0-9 19733289-5 2009 TNF-alpha and IL-6 increased 2- to 3-fold, respectively, in response to placental ischemia but was normalized in RUPP rats treated with 17 OHP. 17-alpha-Hydroxyprogesterone 136-142 interleukin 6 Rattus norvegicus 14-18 20846292-7 2010 For 100% specificity, the sensitivities achieved for ACTH-stimulated 21DF, 17OHP and the quotient [(21DF + 17OHP)/F] were 82 3%, 53 2% and 87%, using cut-offs of 40, 300 ng/dl and 46 (unitless), respectively. 17-alpha-Hydroxyprogesterone 107-112 proopiomelanocortin Homo sapiens 53-57 20220763-1 2010 OBJECTIVE: To determine whether 17-alpha hydroxyprogesterone (17-OHPC) alters tumor necrosis factor-alpha (TNF-alpha) production and the expression of cyclooxygenase type 2 (COX-2) in myometrium exposed to lipopolysaccharide (LPS). 17-alpha-Hydroxyprogesterone 32-60 tumor necrosis factor Homo sapiens 78-105 20220763-1 2010 OBJECTIVE: To determine whether 17-alpha hydroxyprogesterone (17-OHPC) alters tumor necrosis factor-alpha (TNF-alpha) production and the expression of cyclooxygenase type 2 (COX-2) in myometrium exposed to lipopolysaccharide (LPS). 17-alpha-Hydroxyprogesterone 32-60 tumor necrosis factor Homo sapiens 107-116 20132843-3 2010 To identify the limiting factors in a P450 catalyzed whole cell biotransformation, 21-hydroxylation of 17-alpha-hydroxyprogesterone in Schizosaccharomyces pombe expressing human CYP21 was chosen as model reaction. 17-alpha-Hydroxyprogesterone 103-131 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 178-183 19745821-0 2009 Effects of 17-hydroxyprogesterone on tumor necrosis factor-alpha-induced hypertension during pregnancy. 17-alpha-Hydroxyprogesterone 11-33 tumor necrosis factor Rattus norvegicus 37-64 19745821-2 2009 We examined the effect of 17-hydroxyprogesterone caproate (17-OHP) on TNF-alpha-stimulated endothelin (ET) production and hypertension during pregnancy. 17-alpha-Hydroxyprogesterone 59-65 tumor necrosis factor Rattus norvegicus 70-79 19690561-5 2009 Diagnosis is based on elevated levels of 17-hydroxyprogesterone, the preferred substrate for steroid 21-hydroxylase. 17-alpha-Hydroxyprogesterone 41-63 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 93-115 19432978-11 2009 RESULTS: Only progesterone, 20alpha-hydroxyprogesterone and 17alpha-hydroxyprogesterone were able to displace binding of 3H-P4 (P < 0.001) to membrane fractions from CHO cells expressing ovine mPR-alpha. 17-alpha-Hydroxyprogesterone 60-87 S100 calcium binding protein A6 (calcyclin) Mus musculus 196-205 18439591-9 2009 In decreasing order of importance, the following variables predicted insulin resistance: BMI > WHR > age > DHEAS > free T > SHBG > 17-OHP. 17-alpha-Hydroxyprogesterone 149-155 insulin Homo sapiens 69-76 19085698-9 2009 RESULTS: Among hirsute Turkish women with hyperandrogenemia 21.9% was heterozygous carriers of CYP21 mutations; all had basal and stimulated 17-OHP values within the normal range. 17-alpha-Hydroxyprogesterone 141-147 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 95-100 19085698-13 2009 Women with hyperandrogenism who are heterozygous CYP21 mutation carriers have normal basal and stimulated 17-OHP levels. 17-alpha-Hydroxyprogesterone 106-112 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 49-54 18439591-9 2009 In decreasing order of importance, the following variables predicted insulin resistance: BMI > WHR > age > DHEAS > free T > SHBG > 17-OHP. 17-alpha-Hydroxyprogesterone 149-155 sulfotransferase family 2A member 1 Homo sapiens 116-121 18439591-9 2009 In decreasing order of importance, the following variables predicted insulin resistance: BMI > WHR > age > DHEAS > free T > SHBG > 17-OHP. 17-alpha-Hydroxyprogesterone 149-155 sex hormone binding globulin Homo sapiens 139-143 18445671-5 2008 RESULTS: In vitro expression analysis of the mutant K121Q enzyme in transiently transfected COS-7 cells revealed reduced CYP21 activity of 14.0 +/- 5% for the conversion of 17-hydroxyprogesterone and 19.5 +/- 4% for the conversion of progesterone. 17-alpha-Hydroxyprogesterone 173-195 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 121-126 19174530-3 2009 Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to relatively low degree of virilization and comparatively lower 17-OHP serum concentrations in clinically diagnosed female CAH patients. 17-alpha-Hydroxyprogesterone 138-144 nuclear receptor subfamily 3 group C member 1 Homo sapiens 14-37 19174530-3 2009 Recently, the glucocorticoid receptor (GR) N363S-variant has been linked to relatively low degree of virilization and comparatively lower 17-OHP serum concentrations in clinically diagnosed female CAH patients. 17-alpha-Hydroxyprogesterone 138-144 nuclear receptor subfamily 3 group C member 1 Homo sapiens 39-41 19174530-4 2009 We sought to determine whether functional GR gene variants, either increasing (N363S, BclI) or decreasing GR sensitivity (R23K), underlie the variable 17-OHP screening levels in healthy newborns. 17-alpha-Hydroxyprogesterone 151-157 nuclear receptor subfamily 3 group C member 1 Homo sapiens 42-44 19174530-11 2009 However, whether and to which extent genetically determined differences in individual GR sensitivity influence 17-OHP screening levels in conditions of a pathological hypothalamus-pituitary-adrenal gland-axis stimulation and thus may explain false-negative screening results in those affected by CAH remains to be investigated. 17-alpha-Hydroxyprogesterone 111-117 nuclear receptor subfamily 3 group C member 1 Homo sapiens 86-88 19158194-7 2009 We found RBP4 serum concentrations at baseline to be positively correlated with serum levels of testosterone (R = 0.446; P = 0.005), 17-OH progesterone (R = 0.345, P = 0.037), and dehydroepiandrosterone sulfate (R = 0.347; P = 0.041). 17-alpha-Hydroxyprogesterone 133-151 retinol binding protein 4 Homo sapiens 9-13 18603275-6 2008 Agonist profiles also show that mPRalpha, mPRbeta and mPRgamma are activated by ligands, such as 17alpha-hydroxyprogesterone, that are known to activate non-genomic pathways but not nPR. 17-alpha-Hydroxyprogesterone 97-124 progestin and adipoQ receptor family member VII Mus musculus 32-62 19844114-2 2009 Herein, we describe two novel CYP11B1 mutations (g659_660dupTG, p.M92X; g.4817G>A, p.R453Q) found in a patient diagnosed with classic 11OHD, after presenting with borderline elevated 17-hydroxyprogesterone concentrations in CAH newborn screening. 17-alpha-Hydroxyprogesterone 186-208 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 30-37 18957504-12 2009 CONCLUSIONS: CYP2C19 and CYP3A4 can 21-hydroxylate progesterone but not 17OHP, possibly ameliorating mineralocorticoid deficiency, but not glucocorticoid deficiency. 17-alpha-Hydroxyprogesterone 72-77 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 13-20 18957504-12 2009 CONCLUSIONS: CYP2C19 and CYP3A4 can 21-hydroxylate progesterone but not 17OHP, possibly ameliorating mineralocorticoid deficiency, but not glucocorticoid deficiency. 17-alpha-Hydroxyprogesterone 72-77 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 25-31 17992539-2 2008 The diagnosis of non-classical (NC) 21-hydroxylase deficiency (21-OH-D) was substantiated by the finding of increased baseline and adrenocorticotropic hormone (ACTH)-stimulated 17-hydroxy-progesterone levels and was supported by molecular analyses of the CYP21A2 gene, which revealed V281L homozygosis in patient 1 and V281L/P30L compound heterozygosis in patient 2. 17-alpha-Hydroxyprogesterone 177-200 proopiomelanocortin Homo sapiens 131-158 17992539-2 2008 The diagnosis of non-classical (NC) 21-hydroxylase deficiency (21-OH-D) was substantiated by the finding of increased baseline and adrenocorticotropic hormone (ACTH)-stimulated 17-hydroxy-progesterone levels and was supported by molecular analyses of the CYP21A2 gene, which revealed V281L homozygosis in patient 1 and V281L/P30L compound heterozygosis in patient 2. 17-alpha-Hydroxyprogesterone 177-200 proopiomelanocortin Homo sapiens 160-164 17119906-5 2007 Functional assays of mutagenized CYP21 were performed in transiently transfected mammalian cells in vitro, and enzymatic ability of substrate conversion of the two natural substrates of CYP21-17-hydroxyprogesterone and progesterone-was determined. 17-alpha-Hydroxyprogesterone 192-214 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 186-191 18032381-1 2008 We investigated structural and functional properties of bovine cytochrome P450 steroid 21-hydroxylase (P450c21), which catalyzes hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone. 17-alpha-Hydroxyprogesterone 171-198 steroid 21-hydroxylase Bos taurus 103-110 17462643-10 2008 CONCLUSION(S): Serum 17OH-P is highly correlated with ITT in gonadotropin-suppressed normal men receiving T and stimulated with hCG. 17-alpha-Hydroxyprogesterone 21-27 chorionic gonadotropin subunit beta 5 Homo sapiens 128-131 18493139-5 2008 Since 60-min post-ACTH serum values for 17-hydroxyprogesterone correlate negatively with basal serum insulin levels (all female monkeys on pioglitazone and placebo treatment combined), while similar DHEAS values correlate positively with basal serum insulin levels, circulating insulin levels may preferentially support adrenal androgen biosynthesis in both prenatally androgenized and control female rhesus monkeys. 17-alpha-Hydroxyprogesterone 40-62 insulin Macaca mulatta 101-108 18032381-3 2008 In relation to this, it is noted that the O-O stretching mode (nu(O-O)) of the oxygen complex of P450c21 was sensitive to the substrate; the progesterone- or 17alpha-hydroxyprogesterone-bound enzyme gave single (at 1137 cm(-1)) or split nu(O-O) bands (at 1124 and 1138 cm(-1)), respectively, demonstrating the presence of two forms for the latter. 17-alpha-Hydroxyprogesterone 158-185 steroid 21-hydroxylase Bos taurus 97-104 18308097-9 2008 CONCLUSIONS: Our results suggest reduced activity of CYP21A2 (P450c21), the enzyme that converts progesterone to corticosterone and 17-hydroxyprogesterone to 11-deoxycortisol. 17-alpha-Hydroxyprogesterone 132-154 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 53-60 17785360-0 2007 17-hydroxyprogesterone responses to gonadotropin-releasing hormone disclose distinct phenotypes of functional ovarian hyperandrogenism and polycystic ovary syndrome. 17-alpha-Hydroxyprogesterone 0-22 gonadotropin releasing hormone 1 Homo sapiens 36-66 17785360-11 2007 In a multiple regression model applied in all PCOS women, insulin(AUC) but not androgens or markers of insulin resistance predicted the 17-hydroxyprogesterone response to buserelin to a highly significant extent (t = 3.269; P < 0.01). 17-alpha-Hydroxyprogesterone 136-158 insulin Homo sapiens 58-65 17785360-13 2007 We have shown that women with an exaggerated 17-hydroxyprogesterone response to a GnRH agonist, buserelin, are characterized by more severe hyperandrogenemia, glucose-stimulated beta-cell insulin secretion, and worse insulin resistance than those without evidence of FOH. 17-alpha-Hydroxyprogesterone 45-67 insulin Homo sapiens 188-195 17785360-13 2007 We have shown that women with an exaggerated 17-hydroxyprogesterone response to a GnRH agonist, buserelin, are characterized by more severe hyperandrogenemia, glucose-stimulated beta-cell insulin secretion, and worse insulin resistance than those without evidence of FOH. 17-alpha-Hydroxyprogesterone 45-67 insulin Homo sapiens 217-224 17356050-11 2007 Moreover, in the PCOS group, INSL3 levels were related to a greater 17OH-progesterone response to buserelin (P = 0.015), an index of ovarian hyperandrogenism. 17-alpha-Hydroxyprogesterone 68-85 insulin like 3 Homo sapiens 29-34 17386955-8 2007 The expressed enzyme catalysed the conversion of progesterone to 17-hydroxyprogesterone as well as 16-hydroxyprogesterone, a product unique to human and chimpanzee CYP17. 17-alpha-Hydroxyprogesterone 65-87 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 164-169