PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26370953-6	2015	Subsequent DNA sequence analysis revealed that overexpression of tadA, galU, fucU, ydeA, ydaC, soxS, nrdH, yiiD, and mltF genes conferred increased resistance towards xanthorrhizol.	xanthorrhizol	167-180	YdeA	Escherichia coli	83-87
29996622-4	2018	In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells.	xanthorrhizol	110-123	TNF superfamily member 11	Homo sapiens	268-319
29996622-4	2018	In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells.	xanthorrhizol	110-123	TNF superfamily member 11	Homo sapiens	321-326
29996622-4	2018	In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells.	xanthorrhizol	125-128	TNF superfamily member 11	Homo sapiens	268-319
29996622-4	2018	In this study, we demonstrated that Curcuma xanthorrhiza supercritical extract (CXS) and its active compound, xanthorrhizol (XAN), exhibit anti-inflammatory effects on lipopolysaccharide (LPS)-treated human gingival fibroblast-1 cells and anti-osteoclastic effects on receptor activator of nuclear factor kappa B ligand (RANKL)-treated RAW264.7 cells.	xanthorrhizol	125-128	TNF superfamily member 11	Homo sapiens	321-326
29330223-0	2018	The antioxidant xanthorrhizol prevents amyloid-beta-induced oxidative modification and inactivation of neprilysin.	xanthorrhizol	16-29	membrane metalloendopeptidase	Homo sapiens	103-113
27695274-9	2016	Xanthorrhizol was the better inhibitor of UGT1A1 (IC50 11.30 +- 0.27 muM) as compared to UGT2B7 while curcumene did not show any inhibition.	xanthorrhizol	0-13	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	42-48
22465013-0	2012	Xanthorrhizol induced DNA fragmentation in HepG2 cells involving Bcl-2 family proteins.	xanthorrhizol	0-13	BCL2 apoptosis regulator	Homo sapiens	65-70
25141924-6	2014	However, using the MCF-7 implanted nude mice model, it was possible to detect significantly increased tumor volumes, a larger tumor size, and increased protein expression of P38 and P27(Kip1) in the xanthorrhizol + tamoxifen group compared to the tamoxifen-alone group.	xanthorrhizol	199-212	mitogen-activated protein kinase 14	Mus musculus	174-177
25141924-6	2014	However, using the MCF-7 implanted nude mice model, it was possible to detect significantly increased tumor volumes, a larger tumor size, and increased protein expression of P38 and P27(Kip1) in the xanthorrhizol + tamoxifen group compared to the tamoxifen-alone group.	xanthorrhizol	199-212	cyclin-dependent kinase inhibitor 1B	Mus musculus	182-190
22627996-2	2013	In this study, xanthorrhizol decreased cell viability, induced apoptosis and decreased the level of full-length PARP in SCC-15 oral squamous cell carcinoma (OSCC) cells.	xanthorrhizol	15-28	poly(ADP-ribose) polymerase 1	Homo sapiens	112-116
22627996-7	2013	Xanthorrhizol-induced activation of p38 MAPK and JNK was blocked by MCI-186.	xanthorrhizol	0-13	mitogen-activated protein kinase 14	Homo sapiens	36-39
22627996-7	2013	Xanthorrhizol-induced activation of p38 MAPK and JNK was blocked by MCI-186.	xanthorrhizol	0-13	mitogen-activated protein kinase 8	Homo sapiens	49-52
22627996-9	2013	In conclusion, xanthorrhizol may induce caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells and prevent chemical-induced oral carcinogenesis.	xanthorrhizol	15-28	mitogen-activated protein kinase 14	Homo sapiens	91-94
22627996-9	2013	In conclusion, xanthorrhizol may induce caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells and prevent chemical-induced oral carcinogenesis.	xanthorrhizol	15-28	mitogen-activated protein kinase 8	Homo sapiens	104-107
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	BH3 interacting domain death agonist	Homo sapiens	124-127
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	BCL2 apoptosis regulator	Homo sapiens	162-167
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	BCL2 like 1	Homo sapiens	172-180
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	collagen type XI alpha 2 chain	Homo sapiens	205-209
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	DNA fragmentation factor subunit alpha	Homo sapiens	214-219
22465013-4	2012	Apoptosis in xanthorrhizol-treated HepG2 cells as observed by scanning electron microscopy was accompanied by truncation of BID; reduction of both anti-apoptotic Bcl-2 and Bcl-X(L) expression; cleavage of PARP and DFF45/ICAD proteins and DNA fragmentation.	xanthorrhizol	13-26	DNA fragmentation factor subunit alpha	Homo sapiens	220-224
22465013-5	2012	Taken together, these results suggest xanthorrhizol as a potent antiproliferative agent on HepG2 cells by inducing apoptosis via Bcl-2 family members.	xanthorrhizol	38-51	BCL2 apoptosis regulator	Homo sapiens	129-134
19926935-2	2009	In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model.	xanthorrhizol	25-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	50-66
19881304-8	2009	Our results showed that xanthorrhizol significantly increased Gal-4/ER luciferase activity in a dose-dependent manner and induced the endogenous ER-estrogen response element (ERE) interaction in MCF-7 cells.	xanthorrhizol	24-37	galectin 4	Homo sapiens	62-67
19881304-9	2009	Xanthorrhizol also significantly enhanced the expression of the pS2 gene in MCF-7 cells.	xanthorrhizol	0-13	taste 2 receptor member 64 pseudogene	Homo sapiens	64-67
19926935-2	2009	In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model.	xanthorrhizol	25-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-73
19926935-2	2009	In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model.	xanthorrhizol	25-38	nitric oxide synthase 2	Homo sapiens	79-110
19926935-2	2009	In our previous studies, xanthorrhizol suppressed cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, inhibited cancer cell growth, and exerted an anti-metastatic effect in an animal model.	xanthorrhizol	25-38	nitric oxide synthase 2	Homo sapiens	112-116
19926935-8	2009	The apoptosis by xanthorrhizol was markedly evidenced by induction of DNA fragmentation, release of cytochrome c, activation of caspases, and cleavage of poly-(ADP-ribose) polymerase.	xanthorrhizol	17-30	cytochrome c, somatic	Homo sapiens	100-112
19926935-8	2009	The apoptosis by xanthorrhizol was markedly evidenced by induction of DNA fragmentation, release of cytochrome c, activation of caspases, and cleavage of poly-(ADP-ribose) polymerase.	xanthorrhizol	17-30	poly(ADP-ribose) polymerase 1	Homo sapiens	154-182
19926935-9	2009	In addition, xanthorrhizol increased the expression and promoter activity of pro-apoptotic non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1).	xanthorrhizol	13-26	growth differentiation factor 15	Homo sapiens	146-151
17234720-0	2007	Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B.	xanthorrhizol	0-13	ornithine decarboxylase, structural 1	Mus musculus	157-180
17234720-9	2007	Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen-activated protein kinases and/or Akt.	xanthorrhizol	52-65	nitric oxide synthase 2, inducible	Mus musculus	217-221
19277961-3	2009	We investigated the effects of xanthorrhizol, isolated from Curcuma xanthorrhiza, on the expression of MMP-1 and type-I procollagen in UV-irradiated human skin fibroblasts.	xanthorrhizol	31-44	matrix metallopeptidase 1	Homo sapiens	103-108
19277961-5	2009	Xanthorrhizol (0.001-0.1 microM) and C. xanthorrhiza extract (0.01-0.5 microg/mL) induced a significant, dose-dependent decrease in the expression of MMP-1 protein, and increased the expression of type-1 procollagen.	xanthorrhizol	0-13	matrix metallopeptidase 1	Homo sapiens	150-155
19277961-6	2009	At a concentration of 0.1 microM, xanthorrhizol nearly completely abrogated MMP-1 expression.	xanthorrhizol	34-47	matrix metallopeptidase 1	Homo sapiens	76-81
19277961-7	2009	The MMP-1-suppressing and type-1 procollagen-inducing effects of xanthorrhizol treatment were greater than those of epigallocatechin 3-O-gallate (EGCG), which is known to be a natural anti-aging agent.	xanthorrhizol	65-78	matrix metallopeptidase 1	Homo sapiens	4-9
19189649-5	2008	Treatment with xanthorrhizol caused 50% growth inhibition on MDA-MB-231 cells at 8.67 +/- 0.79 microg/ml as determined by sulforhodamine B (SRB) assay.	xanthorrhizol	15-28	chaperonin containing TCP1 subunit 4	Homo sapiens	122-138
19189649-5	2008	Treatment with xanthorrhizol caused 50% growth inhibition on MDA-MB-231 cells at 8.67 +/- 0.79 microg/ml as determined by sulforhodamine B (SRB) assay.	xanthorrhizol	15-28	chaperonin containing TCP1 subunit 4	Homo sapiens	140-143
19189649-11	2008	These data suggest treatment with xanthorrhizol modulates MDA-MB-231 cell apoptosis through the mitochondria-mediated pathway subsequent to the disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase-3 and caspase-9, and the modulation of PARP-1 protein.	xanthorrhizol	34-47	cytochrome c, somatic	Homo sapiens	208-220
19189649-11	2008	These data suggest treatment with xanthorrhizol modulates MDA-MB-231 cell apoptosis through the mitochondria-mediated pathway subsequent to the disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase-3 and caspase-9, and the modulation of PARP-1 protein.	xanthorrhizol	34-47	caspase 3	Homo sapiens	236-245
19189649-11	2008	These data suggest treatment with xanthorrhizol modulates MDA-MB-231 cell apoptosis through the mitochondria-mediated pathway subsequent to the disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase-3 and caspase-9, and the modulation of PARP-1 protein.	xanthorrhizol	34-47	caspase 9	Homo sapiens	250-259
19189649-11	2008	These data suggest treatment with xanthorrhizol modulates MDA-MB-231 cell apoptosis through the mitochondria-mediated pathway subsequent to the disruption of mitochondrial transmembrane potential, release of cytochrome c, activation of caspase-3 and caspase-9, and the modulation of PARP-1 protein.	xanthorrhizol	34-47	poly(ADP-ribose) polymerase 1	Homo sapiens	283-289
17234720-9	2007	Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen-activated protein kinases and/or Akt.	xanthorrhizol	52-65	prostaglandin-endoperoxide synthase 2	Mus musculus	226-231
17234720-9	2007	Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen-activated protein kinases and/or Akt.	xanthorrhizol	52-65	thymoma viral proto-oncogene 1	Mus musculus	301-304
17234720-0	2007	Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B.	xanthorrhizol	0-13	prostaglandin-endoperoxide synthase 2	Mus musculus	182-234
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	ornithine decarboxylase, structural 1	Mus musculus	152-175
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	ornithine decarboxylase, structural 1	Mus musculus	177-180
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	prostaglandin-endoperoxide synthase 2	Mus musculus	183-199
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	prostaglandin-endoperoxide synthase 2	Mus musculus	201-206
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	nitric oxide synthase 2, inducible	Mus musculus	212-243
17234720-5	2007	To further elucidate the molecular mechanisms underlying the antitumor-promoting activity of xanthorrhizol, its effect on the TPA-induced expression of ornithine decarboxylase (ODC), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) and the upstream signaling molecules controlling these proteins were explored in mouse skin.	xanthorrhizol	93-106	nitric oxide synthase 2, inducible	Mus musculus	245-249
17234720-6	2007	The pre-treatment with xanthorrhizol inhibited the expression of ODC, iNOS and COX-2 proteins and nuclear factor-kappaB (NF-kappaB) activation in both mouse skin with TPA-induced acute inflammation and DMBA-initiated mouse skin promoted by TPA for 19 weeks.	xanthorrhizol	23-36	ornithine decarboxylase, structural 1	Mus musculus	65-68
17234720-6	2007	The pre-treatment with xanthorrhizol inhibited the expression of ODC, iNOS and COX-2 proteins and nuclear factor-kappaB (NF-kappaB) activation in both mouse skin with TPA-induced acute inflammation and DMBA-initiated mouse skin promoted by TPA for 19 weeks.	xanthorrhizol	23-36	nitric oxide synthase 2, inducible	Mus musculus	70-74
17234720-6	2007	The pre-treatment with xanthorrhizol inhibited the expression of ODC, iNOS and COX-2 proteins and nuclear factor-kappaB (NF-kappaB) activation in both mouse skin with TPA-induced acute inflammation and DMBA-initiated mouse skin promoted by TPA for 19 weeks.	xanthorrhizol	23-36	prostaglandin-endoperoxide synthase 2	Mus musculus	79-84
17234720-7	2007	When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB.	xanthorrhizol	72-85	ornithine decarboxylase, structural 1	Mus musculus	126-129
17234720-7	2007	When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB.	xanthorrhizol	72-85	nitric oxide synthase 2, inducible	Mus musculus	131-135
17234720-7	2007	When mouse skin was treated after TPA-induced production of papillomas, xanthorrhizol remarkably suppressed the expression of ODC, iNOS and COX-2 and inhibited the activation of NF-kappaB.	xanthorrhizol	72-85	prostaglandin-endoperoxide synthase 2	Mus musculus	140-145
17234720-8	2007	Furthermore, western blot analysis showed that xanthorrhizol suppressed the activation of extracellular signal-regulated protein kinase, p38, c-Jun-N-terminal kinase and Akt in mice after topical application for 6 weeks following the induction of papillomas.	xanthorrhizol	47-60	mitogen-activated protein kinase 14	Mus musculus	137-140
17234720-8	2007	Furthermore, western blot analysis showed that xanthorrhizol suppressed the activation of extracellular signal-regulated protein kinase, p38, c-Jun-N-terminal kinase and Akt in mice after topical application for 6 weeks following the induction of papillomas.	xanthorrhizol	47-60	thymoma viral proto-oncogene 1	Mus musculus	170-173
17234720-9	2007	Taken together, the present study demonstrates that xanthorrhizol not only delays or inhibits tumor formation, but also reverses the carcinogenic process at pre-malignant stages by reducing the protein levels of ODC, iNOS and COX-2 regulated by the NF-kappaB, mitogen-activated protein kinases and/or Akt.	xanthorrhizol	52-65	ornithine decarboxylase, structural 1	Mus musculus	212-215
17465228-0	2007	Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells.	xanthorrhizol	70-83	tumor protein p53	Homo sapiens	14-17
17465228-0	2007	Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells.	xanthorrhizol	70-83	BCL2 apoptosis regulator	Homo sapiens	20-25
17465228-4	2007	The antiproliferative activity of xanthorrhizol was due to apoptosis induced in the HepG2 cells and not necrosis, which was confirmed by the Tdt-mediated dUTP nick end labeling (TUNEL) assay.	xanthorrhizol	34-47	DNA nucleotidylexotransferase	Homo sapiens	141-144
17465228-6	2007	The apoptosis mediated by xanthorrhizol in the HepG2 cells was associated with the activation of tumor suppressor p53 and down-regulation of antiapoptotic Bcl-2 protein expression, but not Bax.	xanthorrhizol	26-39	tumor protein p53	Homo sapiens	114-117
17465228-6	2007	The apoptosis mediated by xanthorrhizol in the HepG2 cells was associated with the activation of tumor suppressor p53 and down-regulation of antiapoptotic Bcl-2 protein expression, but not Bax.	xanthorrhizol	26-39	BCL2 apoptosis regulator	Homo sapiens	155-160
17465228-7	2007	The levels of Bcl-2 protein expression decreased 24-h after treatment with xanthorrhizol and remained lower than controls throughout the experiment, resulting in a shift in the Bax to Bcl-2 ratio thus favouring apoptosis.	xanthorrhizol	75-88	BCL2 apoptosis regulator	Homo sapiens	14-19
17465228-7	2007	The levels of Bcl-2 protein expression decreased 24-h after treatment with xanthorrhizol and remained lower than controls throughout the experiment, resulting in a shift in the Bax to Bcl-2 ratio thus favouring apoptosis.	xanthorrhizol	75-88	BCL2 associated X, apoptosis regulator	Homo sapiens	177-180
17465228-7	2007	The levels of Bcl-2 protein expression decreased 24-h after treatment with xanthorrhizol and remained lower than controls throughout the experiment, resulting in a shift in the Bax to Bcl-2 ratio thus favouring apoptosis.	xanthorrhizol	75-88	BCL2 apoptosis regulator	Homo sapiens	184-189
15536542-6	2005	This study suggested that the phosphorylation of JNKs could be involved in the protective effect of xanthorrhizol on cisplatin-induced hepatotoxicity and it also affects gene transcription by regulating the expression of transcription factor subunits such as c-fos and p50 in part.	xanthorrhizol	100-113	dynactin 2	Mus musculus	269-272
17201174-7	2006	The level of p53 was greatly increased, whilst PARP-1 was cleaved to 85 kDa subunits, following the treatment with xanthorrhizol at a dose-dependent manner.	xanthorrhizol	115-128	tumor protein p53	Homo sapiens	13-16
17201174-7	2006	The level of p53 was greatly increased, whilst PARP-1 was cleaved to 85 kDa subunits, following the treatment with xanthorrhizol at a dose-dependent manner.	xanthorrhizol	115-128	poly(ADP-ribose) polymerase 1	Homo sapiens	47-53
17201174-8	2006	These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels.	xanthorrhizol	37-50	BCL2 apoptosis regulator	Homo sapiens	144-149
17201174-8	2006	These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels.	xanthorrhizol	37-50	tumor protein p53	Homo sapiens	151-154
17201174-8	2006	These results, thereby, suggest that xanthorrhizol has antiproliferative effects on MCF-7 cells by inducing apoptosis through the modulation of bcl-2, p53 and PARP-1 protein levels.	xanthorrhizol	37-50	poly(ADP-ribose) polymerase 1	Homo sapiens	159-165
16273545-7	2005	The production of proinflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha in activated microglial cells, was reduced by xanthorrhizol.	xanthorrhizol	145-158	interleukin 6	Mus musculus	53-98
16158967-0	2005	Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells.	xanthorrhizol	0-13	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
16158967-0	2005	Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells.	xanthorrhizol	0-13	tumor protein p53	Homo sapiens	65-68
16158967-5	2005	Xanthorrhizol significantly increased apoptosis in HeLa cells, as evaluated by the Tdt-mediated dUTP nick end-labelling (TUNEL) assay and nuclear morphology by Hoechst 33258 staining.	xanthorrhizol	0-13	DNA nucleotidylexotransferase	Homo sapiens	83-86
16158967-6	2005	Western blot analysis, which was further confirmed by the immunostaining results, implied an up-regulation of tumor suppressor protein p53 and the pro-apoptotic protein Bax, following the treatment with xanthorrhizol.	xanthorrhizol	203-216	tumor protein p53	Homo sapiens	135-138
16158967-6	2005	Western blot analysis, which was further confirmed by the immunostaining results, implied an up-regulation of tumor suppressor protein p53 and the pro-apoptotic protein Bax, following the treatment with xanthorrhizol.	xanthorrhizol	203-216	BCL2 associated X, apoptosis regulator	Homo sapiens	169-172
16158967-8	2005	Hence, xanthorrhizol is a promising antiproliferative and anticancer agent which induces p53 and Bax-dependent apoptosis in HeLa cervical cancer cells.	xanthorrhizol	7-20	tumor protein p53	Homo sapiens	89-92
16158967-8	2005	Hence, xanthorrhizol is a promising antiproliferative and anticancer agent which induces p53 and Bax-dependent apoptosis in HeLa cervical cancer cells.	xanthorrhizol	7-20	BCL2 associated X, apoptosis regulator	Homo sapiens	97-100
15536542-5	2005	However, cisplatin-induced phosphorylation of JNKs, especially JNK1, was highly attenuated by pretreatment with xanthorrhizol in a dose-dependent manner.	xanthorrhizol	112-125	mitogen-activated protein kinase 8	Mus musculus	63-67
15536542-8	2005	This is the first report giving evidence that the physiological function of xanthorrhizol is linked to regulation of the phosphorylation of JNK(s).	xanthorrhizol	76-89	mitogen-activated protein kinase 8	Mus musculus	140-143
33683188-0	2021	Xanthorrhizol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Modulating Akt/eNOS Signaling and the NF-[Formula: see text]B-Dependent Expression of Cell Adhesion Molecules.	xanthorrhizol	0-13	thymoma viral proto-oncogene 1	Mus musculus	95-98
15567173-5	2005	Higher expression levels of cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), and phosphorylated extracellular signal-regulated kinase (ERK) were observed in the metastatic group compared with control, but these were attenuated by the treatment of xanthorrhizol.	xanthorrhizol	260-273	mitogen-activated protein kinase 1	Mus musculus	148-151
15567173-6	2005	In conclusion, xanthorrhizol exerts anti-metastatic activity in vivo and this effect could be highly linked to the metastasis-related multiplex signal pathway including ERK, COX-2, and MMP-9.	xanthorrhizol	15-28	mitogen-activated protein kinase 1	Mus musculus	169-172
15567173-6	2005	In conclusion, xanthorrhizol exerts anti-metastatic activity in vivo and this effect could be highly linked to the metastasis-related multiplex signal pathway including ERK, COX-2, and MMP-9.	xanthorrhizol	15-28	prostaglandin-endoperoxide synthase 2	Mus musculus	174-179
15567173-6	2005	In conclusion, xanthorrhizol exerts anti-metastatic activity in vivo and this effect could be highly linked to the metastasis-related multiplex signal pathway including ERK, COX-2, and MMP-9.	xanthorrhizol	15-28	matrix metallopeptidase 9	Mus musculus	185-190
15094305-9	2004	In conclusion, the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors, NF-kappaB and AP-1, could be one possible mechanism to elucidate the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity.	xanthorrhizol	30-43	jun proto-oncogene	Mus musculus	123-127
15094305-9	2004	In conclusion, the ability of xanthorrhizol to regulate the DNA-binding activities of transcription factors, NF-kappaB and AP-1, could be one possible mechanism to elucidate the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity.	xanthorrhizol	199-212	jun proto-oncogene	Mus musculus	123-127
12086400-6	2002	Western blot analyses revealed that the inhibitory potential of xanthorrhizol on the COX-2 activity coincided well with the suppression of COX-2 protein expression in LPS-induced macrophages.	xanthorrhizol	64-77	cytochrome c oxidase II, mitochondrial	Mus musculus	85-90
12086400-6	2002	Western blot analyses revealed that the inhibitory potential of xanthorrhizol on the COX-2 activity coincided well with the suppression of COX-2 protein expression in LPS-induced macrophages.	xanthorrhizol	64-77	cytochrome c oxidase II, mitochondrial	Mus musculus	139-144
34664399-6	2022	In addition, XNT treatment alters the DeltaPsim, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.	xanthorrhizol	13-16	BCL2 like 1	Homo sapiens	227-233
34664399-6	2022	In addition, XNT treatment alters the DeltaPsim, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.	xanthorrhizol	13-16	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146
34664399-6	2022	In addition, XNT treatment alters the DeltaPsim, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.	xanthorrhizol	13-16	caspase 3	Homo sapiens	153-163
34664399-6	2022	In addition, XNT treatment alters the DeltaPsim, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.	xanthorrhizol	13-16	cytochrome c, somatic	Homo sapiens	171-183
34664399-6	2022	In addition, XNT treatment alters the DeltaPsim, thereby induces apoptosis was closely coordinated with the induction of pro-apoptotic markers Bax, Bad, caspase- 3, 9 and cytochrome c, and suppression of anti-apoptotic (Bcl-2, Bcl-XL) protein expression.	xanthorrhizol	13-16	BCL2 apoptosis regulator	Homo sapiens	220-225
33683188-0	2021	Xanthorrhizol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Modulating Akt/eNOS Signaling and the NF-[Formula: see text]B-Dependent Expression of Cell Adhesion Molecules.	xanthorrhizol	0-13	nitric oxide synthase 3, endothelial cell	Mus musculus	99-103
33683188-4	2021	Xanthorrhizol at noncytotoxic concentrations inhibited the proliferation, migration, and formation of capillary-like tubes in VEGF-treated human umbilical vein endothelial cells (HUVECs).	xanthorrhizol	0-13	vascular endothelial growth factor A	Homo sapiens	126-130
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	thymoma viral proto-oncogene 1	Mus musculus	47-50
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	nitric oxide synthase 3, endothelial cell	Mus musculus	55-88
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	nitric oxide synthase 3, endothelial cell	Mus musculus	90-94
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	vascular cell adhesion molecule 1	Mus musculus	118-158
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	selectin, endothelial cell	Mus musculus	163-173
33683188-5	2021	Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase (eNOS) and the expression of vascular cell adhesion molecule (VCAM)-1 and E-selectin in VEGF-treated HUVECs.	xanthorrhizol	0-13	vascular endothelial growth factor A	Homo sapiens	177-181
33683188-6	2021	The expression and transcriptional activity of NF-[Formula: see text]B were downregulated by xanthorrhizol in VEGF-treated HUVECs.	xanthorrhizol	93-106	vascular endothelial growth factor A	Homo sapiens	110-114
33683188-7	2021	Furthermore, xanthorrhizol significantly inhibited VEGF-induced angiogenesis in the chorioallantoic membrane of fertilized eggs and Matrigel plugs subcutaneously injected into mice.	xanthorrhizol	13-26	vascular endothelial growth factor A	Mus musculus	51-55
33683188-10	2021	Taken together, xanthorrhizol inhibits VEGF-induced angiogenesis of endothelial cells by blocking the activation of the PI3K/Akt/eNOS axis and subsequent upregulation of adhesion molecules induced by the transcriptional activation of NF-[Formula: see text]B.	xanthorrhizol	16-29	vascular endothelial growth factor A	Mus musculus	39-43
33683188-10	2021	Taken together, xanthorrhizol inhibits VEGF-induced angiogenesis of endothelial cells by blocking the activation of the PI3K/Akt/eNOS axis and subsequent upregulation of adhesion molecules induced by the transcriptional activation of NF-[Formula: see text]B.	xanthorrhizol	16-29	thymoma viral proto-oncogene 1	Mus musculus	125-128
33683188-10	2021	Taken together, xanthorrhizol inhibits VEGF-induced angiogenesis of endothelial cells by blocking the activation of the PI3K/Akt/eNOS axis and subsequent upregulation of adhesion molecules induced by the transcriptional activation of NF-[Formula: see text]B.	xanthorrhizol	16-29	nitric oxide synthase 3, endothelial cell	Mus musculus	129-133