PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10946015-3	2000	Stimulation of CCT activity after LPDS exposure was associated with a 2-fold increase in immunoreactive CCT content and a corresponding increase in [(35)S]methionine incorporation into newly synthesized CCT.	lpds	34-38	t-complex protein 1	Mus musculus	15-18
10946015-3	2000	Stimulation of CCT activity after LPDS exposure was associated with a 2-fold increase in immunoreactive CCT content and a corresponding increase in [(35)S]methionine incorporation into newly synthesized CCT.	lpds	34-38	t-complex protein 1	Mus musculus	104-107
10946015-3	2000	Stimulation of CCT activity after LPDS exposure was associated with a 2-fold increase in immunoreactive CCT content and a corresponding increase in [(35)S]methionine incorporation into newly synthesized CCT.	lpds	34-38	t-complex protein 1	Mus musculus	104-107
10946015-4	2000	LPDS induction of CCT protein was reversible, as it was suppressed to baseline levels by the addition of low density lipoproteins to the culture medium.	lpds	0-4	t-complex protein 1	Mus musculus	18-21
10946015-7	2000	Nuclear run-on assays revealed that LPDS-induced expression of CCT was due, at least in part, to an increase in gene transcription.	lpds	36-40	t-complex protein 1	Mus musculus	63-66
8558080-7	1995	In addition, when the HMG-CoA reductase inhibitor compactin was added to 10% LPDS-DMEM, these levels increased even further and the change in mRNA level seemed to differ between the enzymes and LDLR.	lpds	77-81	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	22-39
10524433-18	1999	At 40 microg/ml, in both NS and LPDS at 24 h, BOPP accumulation in LDL receptor-deficient human fibroblasts (GM019-15C cells) was reduced relative to AG-1522 cells.	lpds	32-36	low density lipoprotein receptor	Homo sapiens	67-79
7595067-7	1995	These data suggest that LPDS induced the LDL-receptor gene by transcriptional mechanism.	lpds	24-28	low density lipoprotein receptor	Homo sapiens	41-53
1479735-7	1992	A specific inhibitory effect on LPL in LPDS was noted in the 7S and 4S fractions separated by gel filtration employing Sephacryl S-200 column chromatography.	lpds	39-43	lipoprotein lipase	Homo sapiens	32-35
8318507-4	1993	LPDS-treated monocytes provided a more homogeneous cell population with regard to LDL receptor activity than did the PHA-treated lymphocytes; they also provided a greater discrimination between the fluorescence of the receptor probes and cellular autofluorescence.	lpds	0-4	low density lipoprotein receptor	Homo sapiens	82-94
2471639-6	1989	Addition of insulin to incubation medium containing LPDS also overcame the suppressive effect of exogenous LDL on the cellular content of mRNA for the LDL receptor.	lpds	52-56	low density lipoprotein receptor	Homo sapiens	151-163
34798409-4	2022	Among them, gypenosides LXXXII-LXXXVII, gynosaponin II, IV and VI suppressed the expression of PCSK9 in LPDS-induced HepG2 cells at 20 muM; gypenosides LXXXII, LXXXV and LXXXVII showed inhibitory activities against PCSK9 at 10 muM; notably, gypenoside LXXXII still exhibited inhibitory activity against PCSK9 at 5 muM.	lpds	104-108	proprotein convertase subtilisin/kexin type 9	Homo sapiens	95-100
1582187-8	1992	Moreover the LDL receptor activity increases when cells are preincubated with medium containing 5% of LPDS.	lpds	102-106	low density lipoprotein receptor	Rattus norvegicus	13-25
2471639-4	1989	When insulin (100 mU/ml) was included in pre-incubation medium containing LPDS, the amount of LDL-receptor mRNA increased approximately twofold.	lpds	74-78	insulin	Homo sapiens	5-12
2836199-7	1988	Inclusion of insulin (100 mU/ml) in the preincubation medium containing LPDS resulted in a twofold increase in LDL-receptor protein and of LDL binding and degradation by intact cells.	lpds	72-76	insulin	Homo sapiens	13-20
2471639-4	1989	When insulin (100 mU/ml) was included in pre-incubation medium containing LPDS, the amount of LDL-receptor mRNA increased approximately twofold.	lpds	74-78	low density lipoprotein receptor	Homo sapiens	94-106
2471639-6	1989	Addition of insulin to incubation medium containing LPDS also overcame the suppressive effect of exogenous LDL on the cellular content of mRNA for the LDL receptor.	lpds	52-56	insulin	Homo sapiens	12-19
3208769-3	1988	The fall in beta-actin mRNA content during incubation with LPDS was not prevented by the addition of cholesterol to the medium.	lpds	59-63	POTE ankyrin domain family member F	Homo sapiens	12-22
19700418-3	2009	We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment results in a significant increase in apoptosis in HT-29 and Colo-205 cells containing the (V600E)B-RAF mutation, but not in HCT-116 and LoVo cells harbouring the (G13D)Ras mutation, or BE cells, which possess two mutations, (G13D)Ras and (G463V)B-RAF.	lpds	86-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	233-238
2999561-4	1985	Comparative studies of the composition of LPDS obtained from normal donors and poorly controlled diabetic patients showed an increase in saturated and total unesterified fatty acids (UFA), lecithin, apolipoprotein A1, and immunoreactive insulin in the LPDS from diabetic patients.	lpds	42-46	apolipoprotein A1	Homo sapiens	199-216
33493534-3	2021	We found that LPDS induced mtAQP8 expression and that AQP8 gene silencing significantly down-regulated the LPDS-induced synthesis of cholesterol and fatty acids as well as the expression of the corresponding key biosynthetic enzymes, 3-hydroxy-3-methylglutaryl-CoA reductase and fatty acid synthase.	lpds	14-18	aquaporin 8	Homo sapiens	29-33
33493534-3	2021	We found that LPDS induced mtAQP8 expression and that AQP8 gene silencing significantly down-regulated the LPDS-induced synthesis of cholesterol and fatty acids as well as the expression of the corresponding key biosynthetic enzymes, 3-hydroxy-3-methylglutaryl-CoA reductase and fatty acid synthase.	lpds	14-18	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	234-274
33493534-3	2021	We found that LPDS induced mtAQP8 expression and that AQP8 gene silencing significantly down-regulated the LPDS-induced synthesis of cholesterol and fatty acids as well as the expression of the corresponding key biosynthetic enzymes, 3-hydroxy-3-methylglutaryl-CoA reductase and fatty acid synthase.	lpds	107-111	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	234-274
33493534-3	2021	We found that LPDS induced mtAQP8 expression and that AQP8 gene silencing significantly down-regulated the LPDS-induced synthesis of cholesterol and fatty acids as well as the expression of the corresponding key biosynthetic enzymes, 3-hydroxy-3-methylglutaryl-CoA reductase and fatty acid synthase.	lpds	107-111	fatty acid synthase	Homo sapiens	279-298
19700418-3	2009	We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment results in a significant increase in apoptosis in HT-29 and Colo-205 cells containing the (V600E)B-RAF mutation, but not in HCT-116 and LoVo cells harbouring the (G13D)Ras mutation, or BE cells, which possess two mutations, (G13D)Ras and (G463V)B-RAF.	lpds	86-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	381-386
16699960-3	2006	We show that chronic cholesterol depletion achieved with lipoprotein-deficient serum (LPDS) and 25-hydroxycholesterol (25-HC) treatment resulted in a significant increase in cellular apoptosis and caspase-3 activation.	lpds	86-90	caspase 3	Mus musculus	197-206
16229851-3	2006	PON1 activities and protein in HDL/LPDS, as well as its ability to protect against lipid peroxidation and to stimulate HDL/LPDS-mediated macrophage cholesterol efflux were measured.	lpds	35-39	paraoxonase 1	Homo sapiens	0-4
16229851-4	2006	In LPDS from controls, PON1 protein and a significant paraoxonase activity were found, whereas arylesterase and lactonase activities were substantially reduced compared to HDL, by 78% and 88%, respectively.	lpds	3-7	paraoxonase 1	Homo sapiens	23-27
16784888-6	2006	TM7SF2 mRNA and C14SR protein expression in HepG2 cells grown in delipidated serum (LPDS) plus lovastatin (sterol starvation) were 4- and 8-fold higher, respectively, than in LPDS plus 25-hydroxycholesterol (sterol feeding), resulting in 4-fold higher 3beta-hydroxysterol Delta(14)-reductase activity.	lpds	84-88	transmembrane 7 superfamily member 2	Homo sapiens	0-6