PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33049301-2	2021	In the present study, we demonstrated that alpha-conidendrin inhibited the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor-alpha (TNF-alpha) at an IC50 value of 40-60 muM in human lung adenocarcinoma A549 cells.	conidendrin	43-60	intercellular adhesion molecule 1	Homo sapiens	102-135
33049301-2	2021	In the present study, we demonstrated that alpha-conidendrin inhibited the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor-alpha (TNF-alpha) at an IC50 value of 40-60 muM in human lung adenocarcinoma A549 cells.	conidendrin	43-60	intercellular adhesion molecule 1	Homo sapiens	137-143
33049301-2	2021	In the present study, we demonstrated that alpha-conidendrin inhibited the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor-alpha (TNF-alpha) at an IC50 value of 40-60 muM in human lung adenocarcinoma A549 cells.	conidendrin	43-60	tumor necrosis factor	Homo sapiens	156-183
33049301-2	2021	In the present study, we demonstrated that alpha-conidendrin inhibited the cell-surface expression of intercellular adhesion molecule-1 (ICAM-1) induced by tumor necrosis factor-alpha (TNF-alpha) at an IC50 value of 40-60 muM in human lung adenocarcinoma A549 cells.	conidendrin	43-60	tumor necrosis factor	Homo sapiens	185-194
33049301-4	2021	The TNF-alpha-induced mRNA expression of vascular cell adhesion molecule-1, E-selectin, and cyclooxygenase-2 was also reduced by alpha-conidendrin.	conidendrin	129-146	tumor necrosis factor	Homo sapiens	4-13
33049301-4	2021	The TNF-alpha-induced mRNA expression of vascular cell adhesion molecule-1, E-selectin, and cyclooxygenase-2 was also reduced by alpha-conidendrin.	conidendrin	129-146	vascular cell adhesion molecule 1	Homo sapiens	41-74
33049301-4	2021	The TNF-alpha-induced mRNA expression of vascular cell adhesion molecule-1, E-selectin, and cyclooxygenase-2 was also reduced by alpha-conidendrin.	conidendrin	129-146	selectin E	Homo sapiens	76-86
33049301-4	2021	The TNF-alpha-induced mRNA expression of vascular cell adhesion molecule-1, E-selectin, and cyclooxygenase-2 was also reduced by alpha-conidendrin.	conidendrin	129-146	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-108
33049301-7	2021	Collectively, these results indicated that alpha-conidendrin interfered with the DNA binding of RelA to the ICAM-1 promoter, thereby reducing ICAM-1 transcription.	conidendrin	43-60	RELA proto-oncogene, NF-kB subunit	Homo sapiens	96-100
33049301-7	2021	Collectively, these results indicated that alpha-conidendrin interfered with the DNA binding of RelA to the ICAM-1 promoter, thereby reducing ICAM-1 transcription.	conidendrin	43-60	intercellular adhesion molecule 1	Homo sapiens	108-114
33049301-7	2021	Collectively, these results indicated that alpha-conidendrin interfered with the DNA binding of RelA to the ICAM-1 promoter, thereby reducing ICAM-1 transcription.	conidendrin	43-60	intercellular adhesion molecule 1	Homo sapiens	142-148
31971313-4	2020	alpha-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9.	conidendrin	0-17	tumor protein p53	Homo sapiens	129-132
31971313-4	2020	alpha-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9.	conidendrin	0-17	BCL2 associated X, apoptosis regulator	Homo sapiens	137-140
31971313-4	2020	alpha-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9.	conidendrin	0-17	BCL2 apoptosis regulator	Homo sapiens	160-165
31971313-4	2020	alpha-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9.	conidendrin	0-17	cytochrome c, somatic	Homo sapiens	236-248
31971313-4	2020	alpha-Conidendrin significantly induced apoptosis in breast cancer cells via reactive oxygen species generation, upregulation of p53 and Bax, downregulation of Bcl-2, depolarization of mitochondrial membrane potential (MMP), release of cytochrome c from mitochondria, and activation of caspases-3 and -9.	conidendrin	0-17	caspase 3	Homo sapiens	286-303
31971313-5	2020	alpha-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4.	conidendrin	0-17	tumor protein p53	Homo sapiens	135-138
31971313-5	2020	alpha-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4.	conidendrin	0-17	H3 histone pseudogene 16	Homo sapiens	143-146
31971313-5	2020	alpha-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4.	conidendrin	0-17	cyclin D1	Homo sapiens	166-175
31971313-5	2020	alpha-Conidendrin remarkably inhibited the proliferation of breast cancer cells through induction of cell cycle arrest by upregulating p53 and p21 and downregulating cyclin D1 and CDK4.	conidendrin	0-17	cyclin dependent kinase 4	Homo sapiens	180-184
21138310-2	2011	Among the isolates obtained, alpha-conidendrin (12) showed strong CYP3A4 inhibition with an IC(50) value of 0.2 muM.	conidendrin	29-46	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-72