PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 24241316-3 1985 By using darkened or illuminated leaves in the absence or presence of nitrate, it has been confirmed that nitrate is required in the in-vivo synthesis of NiR and that this synthesis is stimulated by light. Nitrates 106-113 ferredoxin--nitrite reductase, chloroplastic Triticum aestivum 154-157 24241316-8 1985 Nitrate appears to regulate NiR synthesis by triggering transcription whereas the light may control the level of transcription or translation. Nitrates 0-7 ferredoxin--nitrite reductase, chloroplastic Triticum aestivum 28-31 3926614-7 1985 The effect of the nitrates on the venous capacitance system is reflected by the increase in the PEP/LVET ratio where NTGO and NTGB elicited marked actions and those of sustained-release ISDN and IS 5-MN were of a lesser extent. Nitrates 18-26 progestagen associated endometrial protein Homo sapiens 96-99 6427300-0 1984 Methemoglobin levels produced by organic nitrates in patients with coronary artery disease. Nitrates 41-49 hemoglobin subunit gamma 2 Homo sapiens 0-13 16664208-6 1985 Nitrate supply was therefore implicated as limiting to leaf NR activity during the decline associated with flowering and early seed development. Nitrates 0-7 inducible nitrate reductase [NADH] 1 Glycine max 60-62 16664208-8 1985 As no significant increase in leaf NR activity was observed in response to light enhancement alone, leaf nitrate supply was further implicated as more limiting to leaf NR activity than was photosynthate supply during flowering and early seed development. Nitrates 105-112 inducible nitrate reductase [NADH] 1 Glycine max 168-170 16664214-5 1985 Nitrate-grown nr(1) mutant soybean plants yielded a NADH:nitrate reductase (designated iNR) when Blue Sepharose columns were eluted with NADH; NADPH failed to elute any NR form from Blue Sepharose loaded with this extract. Nitrates 0-7 chalcone reductase CHR1 Glycine max 65-74 16664214-10 1985 The iNR preferred NADH over NADPH and had an apparent Michaelis constant of 0.13 millimolar for nitrate.Thus, wild-type soybean contains two forms of constitutive nitrate reductase, both differing in their physical properties from nitrate reductases common in higher plants. Nitrates 96-103 chalcone reductase CHR1 Glycine max 171-180 4089329-0 1985 [Environmental nitrates and the experimental formation of methemoglobin]. Nitrates 15-23 hemoglobin subunit gamma 2 Homo sapiens 58-71 18963604-2 1984 The differential pulse polarographic peak-height is proportional to nitrate concentration from 1 to 50 muM. Nitrates 68-75 latexin Homo sapiens 103-106 4022112-0 1985 Determination of nitrates in milk by ion-chromatography. Nitrates 17-25 Weaning weight-maternal milk Bos taurus 29-33 4022112-1 1985 A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm). Nitrates 47-55 Weaning weight-maternal milk Bos taurus 63-67 4022112-1 1985 A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm). Nitrates 47-55 Weaning weight-maternal milk Bos taurus 75-79 4022112-1 1985 A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm). Nitrates 47-55 Weaning weight-maternal milk Bos taurus 75-79 4022112-1 1985 A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm). Nitrates 47-55 Weaning weight-maternal milk Bos taurus 75-79 6427300-1 1984 To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Nitrates 34-42 hemoglobin subunit gamma 2 Homo sapiens 77-90 6427300-1 1984 To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Nitrates 34-42 hemoglobin subunit gamma 2 Homo sapiens 92-105 6427300-1 1984 To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Nitrates 34-41 hemoglobin subunit gamma 2 Homo sapiens 77-90 6427300-1 1984 To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy. Nitrates 34-41 hemoglobin subunit gamma 2 Homo sapiens 92-105 6427300-7 1984 It is concluded that commonly used dosages of nitrates are capable of causing elevations of methemoglobin which are probably not of routine clinical significance. Nitrates 46-54 hemoglobin subunit gamma 2 Homo sapiens 92-105 16662876-5 1983 Inasmuch as nitrate reduction results in the production of OH(-) and stimulates the synthesis of organic anions, it was postulated that nitrate reductase activity of roots is stimulated by the released OH(-) or by the synthesized organic anions rather than by nitrate itself. Nitrates 12-19 nitrate reductase [NADH] 1 Zea mays 136-153 16663186-5 1983 Nitrate assimilation (nitrate reductase activity and total accumulation of reduced-N) was also enhanced in response to vegetative apex removal. Nitrates 0-7 inducible nitrate reductase [NADH] 1 Glycine max 22-39 6613236-8 1983 SIN 1 effectively dilates nonstenotic and especially stenotic epicardial coronary arteries, as it is already known for nitrates and calcium-channel blockers. Nitrates 119-127 MAPK associated protein 1 Homo sapiens 0-5 6372319-0 1983 Nitrate reduction in so-called nitrate reductase (NR) negative strains of the genus Mycobacterium. Nitrates 0-7 GR01_RS13310 Mycobacterium chelonae 31-48 6372319-0 1983 Nitrate reduction in so-called nitrate reductase (NR) negative strains of the genus Mycobacterium. Nitrates 0-7 GR01_RS13310 Mycobacterium chelonae 50-52 6749995-2 1982 The method involves a sandwich technique in which antiserum to human IgE is adsorbed on a cellulose acetate/nitrate disc which is attached to a plastic StiQTM sampler. Nitrates 108-115 immunoglobulin heavy constant epsilon Homo sapiens 69-72 6874197-7 1983 Clearly elevated nitrate contents were revealed by the resuls of measurements: 13% of samples showed values above the maximal concentration admissible under the EC Drinking Water Directive of 50 mg NO-3/l and 42% above the EC guide level. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 198-202 16346140-1 1982 Bacteria able to perform dissimilatory nitrate reduction to ammonium were isolated from low-oxygen masses in the Baltic Sea. Nitrates 39-46 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 120-123 16662475-0 1982 Differential effect of tungsten on the development of endogenous and nitrate-induced nitrate reductase activities in soybean leaves. Nitrates 69-76 inducible nitrate reductase [NADH] 1 Glycine max 85-102 16662475-1 1982 The effect of tungsten on the development of endogenous and nitrate-induced NADH- and FMNH(2)-linked nitrate reductase activities in primary leaves of 10-day-old soybean (Glycine max [L.] Merr.) Nitrates 60-67 chalcone reductase CHR1 Glycine max 109-118 16662475-4 1982 High levels of endogenous nitrate reductase activities developed in leaves of seedlings grown without nitrate. Nitrates 26-33 chalcone reductase CHR1 Glycine max 34-43 16662475-8 1982 By contrast, in nitrate-grown seedlings, tungsten only inhibited the nitrate-induced portion of NADH-linked nitrate reductase activity, whereas the FMNH(2)-linked activity was inhibited completely. Nitrates 69-76 chalcone reductase CHR1 Glycine max 116-125 16662475-10 1982 The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system. Nitrates 42-49 chalcone reductase CHR1 Glycine max 50-59 16662475-10 1982 The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system. Nitrates 42-49 chalcone reductase CHR1 Glycine max 178-187 16662475-11 1982 The results suggest that in soybean leaves either the endogenous nitrate reductase does not require molybdenum or the molybdenum present in the seed is preferentially utilized by the enzyme complex as compared to nitrate-induced nitrate reductase. Nitrates 65-72 chalcone reductase CHR1 Glycine max 73-82 6141677-6 1983 In the presence of the vital stain methylene blue - which was shown in vitro to prevent nitrate-induced activation of guanylate cyclase, the enzyme which forms cGMP from GTP - the relaxant actions as well as the increases in cGMP produced by several of these nitro-compounds in coronary strips were almost abolished. Nitrates 88-95 guanylate cyclase Bos taurus 118-135 17791587-1 1982 Fog water collected at three sites in Los Angeles and Bakersfield, California, was found to have higher acidity and higher concentrations of sulfate, nitrate, and ammonium than previously observed in atmospheric water droplets. Nitrates 150-157 zinc finger protein, FOG family member 1 Homo sapiens 0-3 16662417-4 1982 Correlations between nitrate or nitrite concentration in nodules and nodule weight/plant were highly significant.Cytosol from soybean nodules was found to contain NADH-dependent nitrate reductase activity (typical activity was 0.1 micromole per milligram protein x hour). Nitrates 21-28 chalcone reductase CHR1 Glycine max 186-195 16662417-6 1982 Growth of nodules formed by the mutant lacking nitrate reductase was inhibited by nitrate. Nitrates 47-54 chalcone reductase CHR1 Glycine max 55-64 16345884-6 1981 Anaerobic treatment of RDX wastewaters, which also contain high nitrate levels, would permit the denitrification to occur, with concurrent degradation of RDX ultimately to a mixture of hydrazines and methanol. Nitrates 64-71 radixin Homo sapiens 23-26 7135816-7 1982 The amount of blood methemoglobin was found to correlate directly with the percent of nitrates in the ration. Nitrates 86-94 hemoglobin subunit gamma 2 Homo sapiens 20-33 7306876-9 1981 This agrees well with the nitrate partitioning observed by the acetylene inhibition method in which 30--40% of the NO3- -N was recovered as N2O. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 115-118 16662109-3 1981 Biosynthetic glutamine synthetase activity was 1.5 to 1.8 times greater in nitrogen-limited cells than cells grown at high levels of the three nitrogen sources.Conversely, glutamate dehydrogenase (both NADH- and NADPH-dependent activities) was greatest in cells grown at high levels of asparagine or ammonium, while nitrate-grown cells possessed little activity at all concentrations employed. Nitrates 316-323 glutamate-ammonia ligase Homo sapiens 13-33 24276702-0 1981 Glutamine synthetase of Chlamydomonas: its role in the control of nitrate assimilation. Nitrates 66-73 glutamate-ammonia ligase Homo sapiens 0-20 6459097-0 1981 The dose of nicorandil in men predicted from the inhibition of MAO activity by organic nitrates. Nitrates 87-95 monoamine oxidase A Rattus norvegicus 63-66 16661906-3 1981 The nitrate-free in vivo assay system of nitrate reductase was used for measuring the production of nitrite. Nitrates 4-11 chalcone reductase CHR1 Glycine max 49-58 6973419-6 1981 Coronary artery bypass grafting in a subgroup of patients did not affect the mean plasma PF4 concentration during 1 year of follow-up after bypass surgery, but medical therapy for angina with increasing doses of propranolol and nitrates significantly reduced PF4 concentration in another subgroup of patients who were not considered to be candidates for surgical therapy. Nitrates 228-236 platelet factor 4 Homo sapiens 259-262 7209517-1 1981 Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered. Nitrates 47-54 NBL1, DAN family BMP antagonist Mus musculus 56-59 7269804-3 1981 When the alimentary nitrate intake is in the range of 50 mg NO3- the nitrate values in saliva of adults and children follow a Gaussian normal distribution. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 60-63 6975421-7 1981 BV1 differs from B. gazogenes in cell size, pattern of pigment production, nutritional characteristics, the ability to perform anaerobic respiration using nitrate as a terminal electron acceptor, sensitivity to a newly discovered lytic phage and to the antibiotic vibriostat O/129. Nitrates 155-162 endogenous ecotropic MuLV 2 Mus musculus 0-3 7269804-3 1981 When the alimentary nitrate intake is in the range of 50 mg NO3- the nitrate values in saliva of adults and children follow a Gaussian normal distribution. Nitrates 69-76 NBL1, DAN family BMP antagonist Homo sapiens 60-63 16345620-1 1980 During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism. Nitrates 73-80 MS Homo sapiens 52-56 16661600-4 1980 Increases in nitrate supply resulted in decreases in nitrate reductase activity and negligible increases in reduced N in the roots of both hybrids. Nitrates 13-20 nitrate reductase [NADH] 1 Zea mays 53-70 16661600-6 1980 Hybrid B also had lower nitrate reductase activity at all levels of external nitrate and accumulated less reduced N than did hybrid C, except when the plants were grown at 2.5 millimolar nitrate. Nitrates 77-84 nitrate reductase [NADH] 1 Zea mays 24-41 16661493-4 1980 Cells which survived the chlorate treatment then were transferred to casein hydrolysate medium and have been cultured in the absence of chlorate for more than 18 months (NR1).DI-6 cells can grow in a nitrate-based medium, whereas NR1 cells can take up nitrate but cannot use it as a N source. Nitrates 200-207 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 170-173 16661493-4 1980 Cells which survived the chlorate treatment then were transferred to casein hydrolysate medium and have been cultured in the absence of chlorate for more than 18 months (NR1).DI-6 cells can grow in a nitrate-based medium, whereas NR1 cells can take up nitrate but cannot use it as a N source. Nitrates 200-207 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 230-233 16661493-5 1980 The inability of NR1 to assimilate nitrate appears to be due to the lack of an active nitrate reductase in these cells. Nitrates 35-42 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 17-20 16661493-6 1980 Through the use of a variety of electron donors and acceptors, the lack of nitrate reductase activity in NR1 cells was shown to be due to the absence of, or a defect in, that component of the enzyme which mediates the reduction of nitrate to nitrite.In other experiments, DI-6 and NR1 were grown on a solid medium containing casein hydrolysate (2 grams liter(-1)) as the sole N source. Nitrates 75-82 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 105-108 16661493-6 1980 Through the use of a variety of electron donors and acceptors, the lack of nitrate reductase activity in NR1 cells was shown to be due to the absence of, or a defect in, that component of the enzyme which mediates the reduction of nitrate to nitrite.In other experiments, DI-6 and NR1 were grown on a solid medium containing casein hydrolysate (2 grams liter(-1)) as the sole N source. Nitrates 75-82 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 281-284 16345620-1 1980 During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism. Nitrates 273-280 MS Homo sapiens 52-56 6986356-4 1980 Alcohol dehydrogenase production was largely unaffected by catabolite repression but was repressed by nitrate under both aerobic and anaerobic conditions. Nitrates 102-109 Alcohol dehydrogenase Escherichia coli 0-21 7374672-6 1980 The rate constant k2 was temperature-dependent with a Q10 of 1.11 between 5 degrees C and 30 degrees C. Aromatic carboxylic acids known to block sarcolemmal Cl conductance (GCl) specifically lowered k2 by 25% at 30 degrees C, as did replacement of external Cl with nitrate. Nitrates 265-272 germ cell-less 2, spermatogenesis associated Homo sapiens 173-176 16661245-7 1980 Assays of the NADPH-eluted NR with different concentrations of nitrate revealed that the highest activity was obtained in 80 millimolar KNO(3). Nitrates 63-70 inducible nitrate reductase [NADH] 1 Glycine max 27-29 16661245-8 1980 Thus, this fraction has properties similar to the low nitrate affinity NAD(P)H:NR of soybean leaves. Nitrates 54-61 inducible nitrate reductase [NADH] 1 Glycine max 79-81 16661245-10 1980 Assays of this fraction with different nitrate concentrations revealed that this NR had a higher nitrate affinity and was similar to the NADH:NR of soybean leaves. Nitrates 39-46 inducible nitrate reductase [NADH] 1 Glycine max 81-83 16661245-10 1980 Assays of this fraction with different nitrate concentrations revealed that this NR had a higher nitrate affinity and was similar to the NADH:NR of soybean leaves. Nitrates 97-104 inducible nitrate reductase [NADH] 1 Glycine max 81-83 16661380-9 1980 From the patterns of plant nitrate content it was deduced that the low nitrate reductase genotypes terminated nitrate absorption sooner than the high nitrate reductase types. Nitrates 27-34 nitrate reductase [NADH] 1 Zea mays 71-88 16660571-6 1978 Because the specific activity of nitrate reductase was severalfold lower than the other enzymes involved in nitrate assimilation, nitrate reduction is indicated as the rate-limiting step in situ. Nitrates 108-115 nitrate reductase [NADH] 1 Zea mays 33-50 11898-1 1976 Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons. Nitrates 105-112 hemoglobin subunit gamma 2 Homo sapiens 45-58 16660485-15 1978 The inhibition of nitrate reductase was noncompetitive with nitrate but caused a decrease in V(max).The isolated inhibitor was inactivated in the light, but after 24 hours in the dark full inhibitory activity returned. Nitrates 18-25 chalcone reductase CHR1 Glycine max 26-35 868388-1 1977 Ultraviolet light (PRK-2) induces the formation of various amino acids (lysine, asparaginic, as well as traces of some other acids) in mannose, glucose and arabinose solutions containing various nitrates. Nitrates 195-203 protein kinase N2 Homo sapiens 19-24 629538-0 1978 Induction of a dissimilatory reduction pathway of nitrate in Halobacterium of the Dead Sea. Nitrates 50-57 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 87-90 15657-1 1977 A highly purified preparation of glutamine synthetase from chlorella grown on a medium containing nitrate as a sole source of nitrogen, was isolated and characterized by disc-electrophoresis and analytical ultracentrifugation. Nitrates 98-105 glutamate-ammonia ligase Homo sapiens 33-53 184842-6 1976 The proportion of the cytochrome c which is reduced during the second stage is oxidizable by either nitrate or H2O2 and is reduced again when the nitrate or H2O2 have been depleted. Nitrates 100-107 cytochrome c, somatic Homo sapiens 22-34 16659754-2 1976 Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase. Nitrates 18-25 nitrate reductase [NADH] 1 Zea mays 80-97 16659754-2 1976 Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase. Nitrates 18-25 nitrate reductase [NADH] 1 Zea mays 211-228 16659754-2 1976 Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase. Nitrates 80-87 nitrate reductase [NADH] 1 Zea mays 211-228 16659756-4 1976 were designed to determine the relative limitations of NO(3) (-), NADH, and nitrate reductase (NR) per se on nitrate metabolism as affected by light and temperature. Nitrates 76-83 inducible nitrate reductase [NADH] 1 Glycine max 95-97 16659704-2 1976 The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant. Nitrates 20-27 nitrate reductase [NADH] 1 Zea mays 86-103 16659704-2 1976 The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant. Nitrates 40-47 nitrate reductase [NADH] 1 Zea mays 86-103 16659704-2 1976 The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant. Nitrates 40-47 nitrate reductase [NADH] 1 Zea mays 86-103 184842-6 1976 The proportion of the cytochrome c which is reduced during the second stage is oxidizable by either nitrate or H2O2 and is reduced again when the nitrate or H2O2 have been depleted. Nitrates 146-153 cytochrome c, somatic Homo sapiens 22-34 983544-1 1976 Daily intake of nitrate and nitrate by German Federal Republic resident was calculated to 75 mg NO3- and 3.3 mg NO2-. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 96-99 983544-1 1976 Daily intake of nitrate and nitrate by German Federal Republic resident was calculated to 75 mg NO3- and 3.3 mg NO2-. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 96-99 16659360-5 1975 The response to glucose is seen over a wide range of external NO(3) (-) concentrations.Nitrate reductase activity is lost rapidly when nitrate is withdrawn from the induction medium. Nitrates 135-142 nitrate reductase [NADH] 1 Zea mays 87-104 2016-2 1975 Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading. Nitrates 96-103 Rap guanine nucleotide exchange factor 5 Homo sapiens 67-75 16659373-6 1975 The pattern of induction of nitrate reductase was coincident with the pattern of nitrate uptake as a function of time and increasing nitrate concentrations. Nitrates 81-88 nitrate reductase [NADH] 1 Zea mays 28-45 16659373-7 1975 The rate of induction of nitrate reductase was regulated by the rate of nitrate flux.Washing the roots for 2 hours enhances nitrate uptake by 2.5-fold over the nonwashed tissue. Nitrates 72-79 nitrate reductase [NADH] 1 Zea mays 25-42 170914-6 1975 The significance of the enzyme in conjunction with glutamine synthetase in the assimilation of nitrate by roots is discussed. Nitrates 95-102 glutamate-ammonia ligase Homo sapiens 51-71 236776-2 1975 Also dithionite, used to reduce benzylviologen and FMN, inactivates nitrate reductase: however, FMN at an optimal concentration and nitrate, added before the dithionite, protect the enzyme against this inactivation. Nitrates 68-75 formin 1 Homo sapiens 51-54 236776-2 1975 Also dithionite, used to reduce benzylviologen and FMN, inactivates nitrate reductase: however, FMN at an optimal concentration and nitrate, added before the dithionite, protect the enzyme against this inactivation. Nitrates 68-75 formin 1 Homo sapiens 96-99 16658419-3 1973 Experiments were conducted to determine whether the decrease in nitrate reductase activity was due to reduced levels of nitrate in the tissue, direct inactivation of the enzyme by low leaf water potentials, or to changes in rates of synthesis or decay of the enzyme.Although tissue nitrate content decreased with the onset of desiccation, it did not continue to decline with tissue desiccation and loss of enzyme activity. Nitrates 120-127 nitrate reductase [NADH] 1 Zea mays 64-81 24430370-2 1975 over the growing season.The level of nitrate-reductase activity generally paralleled the concentration of nitrate in the leaf tissue over the entire growing season. Nitrates 37-44 chalcone reductase CHR1 Glycine max 45-54 16658419-4 1973 Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity. Nitrates 73-80 nitrate reductase [NADH] 1 Zea mays 0-17 16658419-4 1973 Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity. Nitrates 73-80 nitrate reductase [NADH] 1 Zea mays 157-174 16658419-4 1973 Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity. Nitrates 114-121 nitrate reductase [NADH] 1 Zea mays 0-17 16658419-4 1973 Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity. Nitrates 114-121 nitrate reductase [NADH] 1 Zea mays 157-174 16657550-1 1970 Nitrate reductase activity was induced by nitrate in green corn (Zea mays) leaves in either light or darkness. Nitrates 42-49 nitrate reductase [NADH] 1 Zea mays 0-17 16658530-1 1973 In a study on 3-day maize (Zea mays) seedlings, grown on nitrate, requirements were established for the maximum extraction and optimum stabilization of nitrate reductase in vitro. Nitrates 57-64 nitrate reductase [NADH] 1 Zea mays 152-169 16658530-6 1973 A high level of nitrate (approximately 100 mm) was required to saturate the induction of nitrate reductase in the root tip, mature root, and scutellum. Nitrates 16-23 nitrate reductase [NADH] 1 Zea mays 89-106 16658530-7 1973 The concentration of nitrate required to give half the maximum level of enzyme induced was the same for each region (29 mm).After leaf expansion, more than 90% of the nitrate reductase was in the shoot, mainly in the leaf blade, and a marked decrease occurred in the level of the enzyme in the scutellum. Nitrates 21-28 nitrate reductase [NADH] 1 Zea mays 167-184 16658531-10 1973 The activity of the nitrate reductase inactivating enzyme was not influenced by nitrate and was also found in the mature root of minus nitrate-grown seedlings. Nitrates 80-87 nitrate reductase [NADH] 1 Zea mays 20-37 16657912-4 1972 Soybean contains an active nitrate reductase in roots and leaves, but the low specific activity of this enzyme in sunflower leaves indicates a dependency upon the roots for nitrate reduction. Nitrates 27-34 chalcone reductase CHR1 Glycine max 35-44 16657912-6 1972 Nitrate reductase activity in leaves of nitrate-supplied soybean and sunflower follows closely the distribution of nitrate reductase. Nitrates 40-47 inducible nitrate reductase [NADH] 1 Glycine max 0-17 16657912-6 1972 Nitrate reductase activity in leaves of nitrate-supplied soybean and sunflower follows closely the distribution of nitrate reductase. Nitrates 40-47 chalcone reductase CHR1 Glycine max 8-17 16657913-6 1972 Nitrate roots also maintain a high level of NADPH, presumably by the stimulatory effect of nitrate utilization on glucose-6-phosphate dehydrogenase activity. Nitrates 0-7 glucose-6-phosphate dehydrogenase Glycine max 114-147 16657913-6 1972 Nitrate roots also maintain a high level of NADPH, presumably by the stimulatory effect of nitrate utilization on glucose-6-phosphate dehydrogenase activity. Nitrates 91-98 glucose-6-phosphate dehydrogenase Glycine max 114-147 16657914-9 1972 Maximum total activity shifted to leaf positions lower in the plant canopy with later growth stages.Nitrate reductase activity of soybeans grown in hydroponic systems was significantly higher than activity of adjacent soil grown plants at later growth stages, which suggested that under normal field conditions the potential for nitrate utilization may not be realized. Nitrates 329-336 inducible nitrate reductase [NADH] 1 Glycine max 100-117 4396143-2 1971 The purified enzyme was specific for NADPH and catalyzed reduction of nitrate, cytochrome c from isolated mitochondria of Aspergillus, and mammalian cytochrome c. Nitrates 70-77 cytochrome c, somatic Homo sapiens 149-161 4993525-0 1970 [Effect of nitrates in products of vegetable origin on methemoglobin formation]. Nitrates 11-19 hemoglobin subunit gamma 2 Homo sapiens 55-68 5068711-0 1972 Methemoglobin levels in infants in an area with high nitrate water supply. Nitrates 53-60 hemoglobin subunit gamma 2 Homo sapiens 0-13 4397909-0 1971 The development of methemoglobin in mothers and newborn infants from nitrate in water supplies. Nitrates 69-76 hemoglobin subunit gamma 2 Homo sapiens 19-32 5557824-0 1971 [Regulation of plant glutamine synthetase by ammonium and nitrate]. Nitrates 58-65 glutamate-ammonia ligase Homo sapiens 21-41 4393266-1 1970 In vitro assembly or complementation of a hybrid assimilatory nitrate reductase was attained by mixing a preparation of nitrate-induced N. crassa mutant nit-1 specifically with acid-treated (pH 2.5) bovine milk or intestinal xanthine oxidase, rabbit liver aldehyde oxidase, or chicken liver xanthine dehydrogenase. Nitrates 62-69 xanthine dehydrogenase Gallus gallus 291-313 17774405-1 1968 The interrelations and time-dependence of nitrate, nitrite, and ammonia in a deep basin of the Baltic Sea yield a measurement of stagnation history and may provide a means of prediction of resupply of nutrients to the upper productive layers. Nitrates 42-49 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 102-105 34050740-4 2021 Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth. Nitrates 133-140 Plant regulator RWP-RK family protein Arabidopsis thaliana 33-37 33743462-2 2021 In this study, a three-dimensional model of a large coal waste rock dump constructed in the Elk Valley, British Columbia, Canada was developed to capture the impact of construction history (1981-2012) and solute transport on nitrate (NO3-) release over a 100-year timeframe. Nitrates 225-232 NBL1, DAN family BMP antagonist Homo sapiens 234-237 34043471-7 2021 In skeletal muscle, nitrate treatment upregulated expression of genes central to nutrient sensing (mtor), redox signaling (nrf2a) and muscle differentiation (sox6). Nitrates 20-27 nfe2 like bZIP transcription factor 2a Danio rerio 123-128 34043471-7 2021 In skeletal muscle, nitrate treatment upregulated expression of genes central to nutrient sensing (mtor), redox signaling (nrf2a) and muscle differentiation (sox6). Nitrates 20-27 SRY-box transcription factor 6 Danio rerio 158-162 16742412-11 1966 Nitrite reductase is induced by nitrite and only indirectly by nitrate. Nitrates 63-70 ferredoxin--nitrite reductase, chloroplastic Raphanus sativus 0-17 20294121-0 1947 Studies on reactions relating to carbohydrates and polysaccharides; effect of hot alkali on the nitrates of starch, amylose, and amylopectin. Nitrates 96-104 alcohol dehydrogenase iron containing 1 Homo sapiens 78-81 33736152-6 2021 Organic aerosol (OA) and sulfate were dominant contributor of PM1 in summer, whereas OA and nitrate primarily contribution to the increase of PM1 mass loading in spring and winter. Nitrates 92-99 transmembrane protein 11 Homo sapiens 142-145 34050740-4 2021 Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth. Nitrates 133-140 NIN like protein 7 Arabidopsis thaliana 42-46 34050740-4 2021 Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth. Nitrates 133-140 Plant regulator RWP-RK family protein Arabidopsis thaliana 186-190 34050740-7 2021 Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis. Nitrates 13-20 Plant regulator RWP-RK family protein Arabidopsis thaliana 93-97 34050740-7 2021 Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis. Nitrates 13-20 Plant regulator RWP-RK family protein Arabidopsis thaliana 162-166 34050740-7 2021 Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis. Nitrates 13-20 NIN like protein 7 Arabidopsis thaliana 171-175 33990989-2 2021 By employing ab initio molecular dynamics (AIMD) method, we studied the effects of the proton transfer and the rotation of the nitrates on the vibrational profiles of HNO3 (NO3 - )(H2 O)n (n = 0-2). Nitrates 127-135 NBL1, DAN family BMP antagonist Homo sapiens 168-171 34038101-2 2021 The balance of water coordination and the multitude of bonding of the weakly coordinated nitrate lead to a progressive change in the coordination number of the Cd2+ ions from eight to seven to six without great perturbation to the 4-fold interpenetration three-dimensional framework. Nitrates 89-96 CD2 molecule Homo sapiens 160-163 33903869-1 2021 Herein, we describe the nonlinear processes for the formation of thin films of the PbS-CdS system using chemical bath deposition with a gradual change in the cadmium nitrate content in the reaction mixture. Nitrates 166-173 cholinergic receptor muscarinic 3 Homo sapiens 83-86 33982797-9 2021 Nitrate-containing versus placebo juice significantly lowered CIMT [-0.06 (95% Confidence Interval -0.12, -0.01), p=0.034], an overall difference of ~8% relative to baseline; but had no effect on carotid diameter (CD) or carotid stiffness (CS). Nitrates 0-7 CIMT Homo sapiens 62-66 33966117-6 2021 At 90% WHC, Met + C treatment significantly lessened concentrations of NH4+ and NO3-, nonetheless improved N2O compared to Met treatment. Nitrates 80-84 SAFB like transcription modulator Homo sapiens 12-15 34025702-10 2021 A key indicator of biostimulant performance was increased nitrate content in barley shoot tissue 22 days after N fertilizer application (+17.9-72.2%), that was associated with gene upregulation of root nitrate transporters (NRT1.1, NRT2.1, and NRT1.5). Nitrates 58-65 putative low affinity nitrate transporter Hordeum vulgare 224-228 33482555-1 2021 The effective control and management of nitrate (NO3-) pollution requires the identification of the sources of NO3- pollution in groundwater and quantification of their contribution rates. Nitrates 40-47 NBL1, DAN family BMP antagonist Homo sapiens 49-52 33482555-1 2021 The effective control and management of nitrate (NO3-) pollution requires the identification of the sources of NO3- pollution in groundwater and quantification of their contribution rates. Nitrates 40-47 NBL1, DAN family BMP antagonist Homo sapiens 111-114 33963398-6 2021 Moreover, higher photorespiration and nitrate accumulation were determined in these plants relative to the untransformed control, indicating that overexpression of Trx m favors the photorespiratory N cycle rather than primary nitrate assimilation. Nitrates 38-45 thioredoxin H-type 1 Nicotiana tabacum 164-167 33758916-3 2021 Following N removal, plants activate their Nitrogen Starvation Response (NSR) being characterized in particular by the activation of very high-affinity nitrate transport systems (NRT2.4, NRT2.5) and other sentinel genes involved in N-remobilization such as GDH3. Nitrates 152-159 nitrate transporter 2:1 Arabidopsis thaliana 179-183 33758916-3 2021 Following N removal, plants activate their Nitrogen Starvation Response (NSR) being characterized in particular by the activation of very high-affinity nitrate transport systems (NRT2.4, NRT2.5) and other sentinel genes involved in N-remobilization such as GDH3. Nitrates 152-159 nitrate transporter2.5 Arabidopsis thaliana 187-193 33758916-5 2021 First, HHOs directly repress the high-affinity nitrate transporters, NRT2.4 and NRT2.5. Nitrates 47-54 nitrate transporter 2:1 Arabidopsis thaliana 69-73 33601051-3 2021 We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels. Nitrates 86-93 nitrate transporter 1.1 Arabidopsis thaliana 107-113 33831352-3 2021 Here, we discovered that, independent of nitrogen assimilation, nitrate and ammonium function as primary nitrogen signals to activate TOR in the Arabidopsis leaf primordium. Nitrates 64-71 target of rapamycin Arabidopsis thaliana 134-137 33831352-5 2021 Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions. Nitrates 15-22 RHO-related protein from plants 2 Arabidopsis thaliana 113-117 33831352-5 2021 Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions. Nitrates 15-22 RHO-related protein from plants 2 Arabidopsis thaliana 146-150 33831352-5 2021 Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions. Nitrates 15-22 target of rapamycin Arabidopsis thaliana 160-163 33601051-8 2021 The dynamic interactions between CNGC15 and NRT1.1 therefore controlled the channel activity and Ca2+-influx in a nitrate-dependent manner. Nitrates 114-121 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 33-39 33601051-8 2021 The dynamic interactions between CNGC15 and NRT1.1 therefore controlled the channel activity and Ca2+-influx in a nitrate-dependent manner. Nitrates 114-121 nitrate transporter 1.1 Arabidopsis thaliana 44-50 33601051-3 2021 We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels. Nitrates 187-194 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 70-76 33601051-3 2021 We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels. Nitrates 187-194 nitrate transporter 1.1 Arabidopsis thaliana 107-113 33601051-4 2021 CNGC15 gene expression was induced by nitrate and the CNGC15 protein was localized to the plasma membrane after establishment of young seedlings. Nitrates 38-45 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 0-6 33601051-5 2021 Disruption of CNGC15 gene resulted in the loss of nitrate-induced Ca2+ signature (primary nitrate responses) and retarded root growth, reminiscent to the phenotype observed in the nrt1.1 mutant. Nitrates 50-57 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 14-20 33601051-5 2021 Disruption of CNGC15 gene resulted in the loss of nitrate-induced Ca2+ signature (primary nitrate responses) and retarded root growth, reminiscent to the phenotype observed in the nrt1.1 mutant. Nitrates 90-97 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 14-20 33601051-7 2021 Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel. Nitrates 124-131 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 13-19 33601051-7 2021 Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel. Nitrates 124-131 nitrate transporter 1.1 Arabidopsis thaliana 20-26 33601051-7 2021 Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel. Nitrates 124-131 cyclic nucleotide-gated channel 15 Arabidopsis thaliana 171-177 33210841-0 2021 HBI1-TCP20 interaction positively regulates the CEPs-mediated systemic nitrate acquisition. Nitrates 71-78 chaperonin containing TCP1 subunit 6A Homo sapiens 5-10 33460896-7 2021 Metagenomics analysis revealed that the preferred metabolic pathway of nitrogen was from ammonium to glutamate via glutamine, and the enzymes governing this transformation were glutamine synthetase and glutamate synthetase; while in nitrate based amendment, the conversion from nitrite to ammonium was restrained by the low abundance of nitrite reductase enzyme and therefore retarded the TPH degradation rate. Nitrates 233-240 glutamate-ammonia ligase Homo sapiens 177-197 33624251-2 2021 The GATA transcription factors belonging to type IV zinc-finger proteins, play a significant role in regulating light morphogenesis, nitrate assimilation, and organ development in plants. Nitrates 133-140 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 4-8 33579566-4 2021 Batch tests demonstrated that efficient PD with nitrate-to-nitrite transformation ratio of 97.67% supplying stable nitrite for anammox, and phosphorus was mainly removed using nitrate as electron acceptor via DPR with the ideal phosphorus release/uptake rate (7.73/22.17 mgP/gVSS/h). Nitrates 176-183 matrix Gla protein Homo sapiens 271-274 33949893-8 2021 RESULTS: Spontaneous preterm birth at 20-31 wk was increased in association with tap water nitrate concentrations during pregnancy of 5 to <10mg/L [odds ratio (OR)=1.47; 95% confidence interval (CI): 1.29, 1.67] and >=10mg/L (OR=2.52; 95% CI: 1.49, 4.26) compared with <5mg/L (as nitrogen). Nitrates 91-98 nuclear RNA export factor 1 Homo sapiens 81-84 33949893-12 2021 Notably, we estimated modestly increased odds associated with tap water nitrate concentrations of 5 to <10mg/L (below the federal drinking water standard of 10mg/L) relative to <5mg/L. Nitrates 72-79 nuclear RNA export factor 1 Homo sapiens 62-65 33934458-5 2021 The Diatom/Dino trend is explained by an altered nutrient composition caused by a decadal increase in anthropogenic input, where nitrate increased rapidly while ammonium and phosphate were relatively constant. Nitrates 129-136 damage induced long noncoding RNA Homo sapiens 11-15 33934458-7 2021 Our models predict that the Diatom/Dino ratio will further increase with increasing anthropogenic input and global warming in subtropical estuarine ecosystems with nitrate as the dominant inorganic nitrogen; its ecological consequences are worthy of further investigation. Nitrates 164-171 damage induced long noncoding RNA Homo sapiens 35-39 33210841-4 2021 Here, we demonstrate that the transcription factors HBI1 and TCP20 play important roles in plant growth and development in response to fluctuating nitrate supply. Nitrates 147-154 chaperonin containing TCP1 subunit 6A Homo sapiens 61-66 33210841-5 2021 HBI1 physically interacts with TCP20, and this interaction was enhanced by the nitrate starvation. Nitrates 79-86 chaperonin containing TCP1 subunit 6A Homo sapiens 31-36 33210841-7 2021 Mutation in HBIs and/or TCP20 resulted in impaired systemic nitrate acquisition response. Nitrates 60-67 chaperonin containing TCP1 subunit 6A Homo sapiens 24-29 33210841-8 2021 Our solid genetic and molecular evidences strongly indicate that the HBI1-TCP20 module positively regulates the CEPs-mediated systemic nitrate acquisition. Nitrates 135-142 chaperonin containing TCP1 subunit 6A Homo sapiens 74-79 33927257-1 2021 An increased nitrate (NO3-) concentration in groundwater has been a rising issue on a global scale in recent years. Nitrates 13-20 NBL1, DAN family BMP antagonist Homo sapiens 22-25 33713800-3 2021 We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR). Nitrates 56-63 xanthine dehydrogenase Rattus norvegicus 173-196 33713800-3 2021 We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR). Nitrates 56-63 xanthine dehydrogenase Rattus norvegicus 198-201 33713800-8 2021 During the course of the overall experiment there was a gradual increase of XOR expression in muscle tissue, which likely led to enhanced nitrate to nitrite reduction. Nitrates 138-145 xanthine dehydrogenase Rattus norvegicus 76-79 33947005-1 2021 Beneficial metabolic effects of inorganic nitrate (NO3-) and nitrite (NO2-) in type 2 diabetes mellitus (T2DM) have been documented in animal experiments; however, this is not the case for humans. Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 51-54 33872506-1 2021 Electrocatalytic conversion of nitrate (NO3-) into ammonia can not only eliminate harmful pollutant but also provide a green method for a low-temperature ammonia synthesis. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 40-43 33886581-5 2021 In contrast, in Pkd1RC/RC mice, sodium nitrate supplementation increased serum nitrate/nitrite levels by ~25-fold in the high dose group (P<0.001), but kidney enlargement and percentage cyst area was not altered, regardless of dose. Nitrates 39-46 polycystin 1, transient receptor potential channel interacting Mus musculus 16-22 33900460-8 2021 Most nitrate variation has been recorded at or near the water table where concentrations have ranged between 3.47 and 5.88 mg NO3-N/L, and annual maxima have occurred in late winter/spring, which coincides with when most nitrate leaching occurs from agricultural land. Nitrates 5-12 NBL1, DAN family BMP antagonist Homo sapiens 126-129 33849366-9 2021 CONCLUSIONS: Water, heat, and excipients" nitrite and nitrate levels are the key players, which should collectively exist, to cause NDMA formation during MET tablets manufacturing. Nitrates 54-61 SAFB like transcription modulator Homo sapiens 154-157 33422844-1 2021 Nitrogen losses from intensive agricultural production may end up as high nitrate (NO3-) concentrations in groundwater, with a long-term impact on groundwater quality. Nitrates 74-81 NBL1, DAN family BMP antagonist Homo sapiens 83-86 33787201-4 2021 The platinum salt undergoes a vivid change in color and luminescence upon exposure to aqueous NO3- anions at pH <= 0 caused by substitution of the PF6- anions by aqueous NO3-. Nitrates 94-98 sperm associated antigen 17 Homo sapiens 147-150 33851500-2 2021 The cytochrome P450 TxtE nitrates the indole 4-position of L-tryptophan at room temperature using NO, O 2 and NADPH, and has potential to be developed into a useful aromatic nitration biocatalyst. Nitrates 25-33 2,4-dienoyl-CoA reductase 1 Homo sapiens 110-115 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 221-224 33924662-2 2021 The efficiency of Pb(II) removal from aqueous nitrate solutions was considered as a function of the composition of membrane (effect of polymer, plasticizer, and carrier), feed (effect of initial metal concentration and presence of other metal ions) and stripping phases, and temperature of the process conducting. Nitrates 46-53 submaxillary gland androgen regulated protein 3B Homo sapiens 18-24 33840873-4 2021 By comparing chemical constituents between clean and polluted episodes, we find that the elevated PM1 mass concentration during pollution events should be largely attributable to significant increases in organic matter (OM) and inorganic aerosols like sulfate, nitrate, and ammonium (SNA), indicative of the critical role of primary emissions and secondary aerosols in elevating PM1 pollution levels. Nitrates 261-268 transmembrane protein 11 Homo sapiens 98-101 33826745-0 2021 Different DNA-binding specificities of NLP and NIN transcription factors underlie nitrate-induced control of root nodulation. Nitrates 82-89 nin Lotus japonicus 47-50 33826745-3 2021 Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive. Nitrates 157-164 nin Lotus japonicus 16-32 33826745-3 2021 Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive. Nitrates 157-164 nin Lotus japonicus 34-37 33826745-3 2021 Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive. Nitrates 193-200 nin Lotus japonicus 16-32 33826745-3 2021 Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive. Nitrates 193-200 nin Lotus japonicus 34-37 33826745-4 2021 Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression. Nitrates 45-52 NLP1 Lotus japonicus 105-111 33826745-4 2021 Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression. Nitrates 147-154 NLP1 Lotus japonicus 105-111 33826745-4 2021 Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression. Nitrates 218-225 NLP1 Lotus japonicus 105-111 33450066-3 2021 Whereas ALDH2 is known to directly activate organic nitrates in vessels, the contribution of vascular CYPs is unknown and was studied here. Nitrates 52-60 aldehyde dehydrogenase 2, mitochondrial Mus musculus 8-13 33515769-0 2021 CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis. Nitrates 95-102 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 0-6 33515769-7 2021 Wild-type CPSF30-L rescued defects in APA and nitrate metabolism, but m6A-binding defective mutants did not. Nitrates 46-53 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 10-16 33515769-8 2021 Taken together, our results demonstrated that m6A modification regulates APA in Arabidopsis, and revealed that m6A reader CPSF30-L affects nitrate signaling by controlling APA. Nitrates 139-146 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 122-128 33393351-5 2021 Extrapolation of the experimental data resulted in values for all the nitrate-bands of the afreea i.e. fully hydrated NO3-(aq). Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 118-121 33168291-0 2021 A novel strategy for sequential reduction of nitrate into nitrogen by CO2 anion radical: Experimental study and DFT calculation. Nitrates 45-52 complement C2 Homo sapiens 70-73 33168291-1 2021 In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate. Nitrates 181-188 complement C2 Homo sapiens 38-41 33168291-1 2021 In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate. Nitrates 181-188 complement C2 Homo sapiens 57-60 33168291-1 2021 In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate. Nitrates 181-188 complement C2 Homo sapiens 57-60 33168291-2 2021 The reduction efficiency, products and mechanism of nitrate or nitrite by CO2- radical were investigated based on the results of batch experiments and theoretical calculation using density functional theory (DFT) methods, respectively. Nitrates 52-59 complement C2 Homo sapiens 74-77 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 41-48 complement C2 Homo sapiens 62-65 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 41-48 complement C2 Homo sapiens 221-224 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 62-65 33115598-1 2021 BACKGROUND: Vitamin C may enhance nitric oxide (NO) production through stepwise reduction of dietary nitrate (NO3) to nitrite (NO2) to NO. Nitrates 101-108 NBL1, DAN family BMP antagonist Homo sapiens 110-113 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 62-65 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 221-224 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 62-65 33168291-3 2021 It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2). Nitrates 200-207 complement C2 Homo sapiens 221-224 33168291-4 2021 On this basis, a novel strategy of rapid reduction of nitrate into N2 using CO2- radical was proposed. Nitrates 54-61 complement C2 Homo sapiens 76-79 33168291-5 2021 Specifically, nitrate was firstly reduced into nitrite with the assistance of Zn/Ag bimetal, and then nitrite was further reduced into N2 by CO2- radical. Nitrates 14-21 complement C2 Homo sapiens 141-144 33168291-7 2021 This work provided a promising approach for the reduction of nitrate into nitrogen with high efficiency and high N2 selectivity by CO2- radical. Nitrates 61-68 complement C2 Homo sapiens 131-134 33785324-12 2021 CONCLUSION: These findings support the hypothesis that drinking high nitrate water increases oral nitrate-reducing bacteria, which likely results in increased NOC. Nitrates 69-76 nocturnin Homo sapiens 159-162 33868355-0 2021 Regulation of Lateral Root Development by Shoot-Sensed Far-Red Light via HY5 Is Nitrate-Dependent and Involves the NRT2.1 Nitrate Transporter. Nitrates 80-87 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 73-76 33868355-9 2021 Consistently, a loss-of-function mutant of a nitrate transporter gene NRT2.1 lacked low R:FR-induced lateral root reduction and its root growth was hypersensitive to low nitrate. Nitrates 45-52 nitrate transporter 2:1 Arabidopsis thaliana 70-74 33868355-10 2021 ELONGATED HYPOCOTYL5 (HY5) plays an important role in the root response to low R:FR and we found that it was less sensitive to low nitrate conditions with regards to lateral root growth. Nitrates 131-138 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 10-20 33868355-10 2021 ELONGATED HYPOCOTYL5 (HY5) plays an important role in the root response to low R:FR and we found that it was less sensitive to low nitrate conditions with regards to lateral root growth. Nitrates 131-138 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 22-25 33868355-11 2021 In addition, we found that low R:FR increases NRT2.1 expression and that low nitrate enhances HY5 expression. Nitrates 77-84 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 94-97 33090485-0 2021 Involvement of boron transporter BOR1 in growth under low-boron and high-nitrate conditions in Arabidopsis thaliana. Nitrates 73-80 HCO3- transporter family Arabidopsis thaliana 33-37 33090485-2 2021 It has been reported that nitrate (NO3 - ) concentrations significantly influence B concentrations in leaves and BOR1 mRNA accumulation in roots. Nitrates 26-33 HCO3- transporter family Arabidopsis thaliana 113-117 33127147-12 2021 Vertically increased NO3 radicals may imply the formation of nitrate aerosols and further increase the nitrate content in high- altitude particulate matter. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 21-24 33127147-12 2021 Vertically increased NO3 radicals may imply the formation of nitrate aerosols and further increase the nitrate content in high- altitude particulate matter. Nitrates 103-110 NBL1, DAN family BMP antagonist Homo sapiens 21-24 33785324-12 2021 CONCLUSION: These findings support the hypothesis that drinking high nitrate water increases oral nitrate-reducing bacteria, which likely results in increased NOC. Nitrates 98-105 nocturnin Homo sapiens 159-162 33187786-13 2021 Overall, the results suggest that EVOH-g-DMAC NFM is efficient, low-cost (13 USD/m3) and recyclable material for sustainable removal of nitrate from dairy manure wastewater without requiring any ionic strength or pH adjustment. Nitrates 136-143 neurofilament medium chain Homo sapiens 46-49 33838420-6 2021 Results revealed that pinewood-derived biochar had its maximum performance at pH 2, with predicted equilibrium uptakes of 20.5 and 4.20 mg/g for phosphate and nitrate, respectively at initial solute concentrations of 60 mg/L within 360 min. Nitrates 159-166 phenylalanine hydroxylase Homo sapiens 78-80 33598673-3 2021 The mononitrate species formed is then further reacted with TMS2Pz to doubly deoxygenate nitrate and form [(L-)Ni(NO)]2, dimeric via bridging pyrazolate with bent nitrosyl ligands, representing a two-electron reduction of coordinated nitrate. Nitrates 8-15 serine incorporator 1 Homo sapiens 60-64 33868355-14 2021 Together our results show that nitrate signaling can repress low R:FR responses and that this involves signaling via HY5 and NRT2.1. Nitrates 31-38 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 117-120 33868355-14 2021 Together our results show that nitrate signaling can repress low R:FR responses and that this involves signaling via HY5 and NRT2.1. Nitrates 31-38 nitrate transporter 2:1 Arabidopsis thaliana 125-129 33721901-4 2021 Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio. Nitrates 95-102 glutamine-dependent asparagine synthase 1 Arabidopsis thaliana 14-18 33333400-7 2021 The results of nitrate isotopes indicated that NO3- mainly originated from soil N nitrogen, chemical fertilizer, and manure and sewage wastes. Nitrates 15-22 NBL1, DAN family BMP antagonist Homo sapiens 47-50 33796477-6 2021 Our results revealed that CD18low mice infected with Pb18 survived during the time analyzed; their lungs showed fewer granulomas, a lower fungal load, lower levels of nitrate, and production of high levels of IgG1 in comparison to WT animals. Nitrates 167-174 integrin beta 2 Mus musculus 26-30 33721901-4 2021 Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio. Nitrates 95-102 Raffinose synthase family protein Arabidopsis thaliana 23-28 33721901-4 2021 Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio. Nitrates 202-209 glutamine-dependent asparagine synthase 1 Arabidopsis thaliana 14-18 33721901-4 2021 Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio. Nitrates 202-209 Raffinose synthase family protein Arabidopsis thaliana 23-28 33687628-3 2021 Nitrate reduction resulted in the production of nitrogen gas, while sulfate formed due to sulfide oxidation. Nitrates 0-7 gastrin Homo sapiens 57-60 33264477-1 2021 Diatoms are among the few eukaryotes known to store nitrate (NO3 - ) and to use it as an electron acceptor for respiration in the absence of light and O2 . Nitrates 52-59 NBL1, DAN family BMP antagonist Homo sapiens 61-64 32130090-1 2021 The aim of this study was to determine the effect of five days dietary nitrate (NO3-) consumption on exercise tolerance and thermoregulation during cycling in hot, dry conditions. Nitrates 71-78 NBL1, DAN family BMP antagonist Homo sapiens 80-83 33109332-6 2021 The crystallographic structure of lysozyme with the IL of ethylammonium nitrate present confirmed the loop region was extended, and identified three specific binding sites with nitrate ions, and that the positively charged areas were IL sensitive regions. Nitrates 72-79 lysozyme Homo sapiens 34-42 33284304-11 2021 Compared with the low humidity period, both PM1 and PM2.5 show higher mass fraction of secondary inorganic aerosols (SIA, mainly as nitrate, sulfate and ammonium) and secondary organic aerosols (SOA) during high humidity and fog episodes. Nitrates 132-139 transmembrane protein 11 Homo sapiens 44-47 33462996-1 2021 In order to reduce nitrate in vivo, the spore-specific respiratory nitrate reductase, Nar1, of Streptomyces coelicolor relies on an active cytochrome bcc-aa3 oxidase supercomplex (bcc-aa3 supercomplex). Nitrates 19-26 SCO2473 Streptomyces coelicolor A3(2) 67-84 33637855-2 2021 Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Nitrates 229-236 nitrate transporter 1.1 Arabidopsis thaliana 186-192 33569852-4 2021 Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- . Nitrates 106-113 NBL1, DAN family BMP antagonist Homo sapiens 180-183 33569852-4 2021 Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- . Nitrates 106-113 NBL1, DAN family BMP antagonist Homo sapiens 200-203 33686225-6 2021 Collectively, our results identify CEPH as a crucial enzyme in the N-starvation-dependent activation of NRT2.1 and provide molecular and mechanistic insights into how plants regulate high-affinity nitrate uptake at the post-translational level in response to the N environment. Nitrates 197-204 nitrate transporter 2:1 Arabidopsis thaliana 104-110 33331676-0 2021 Abscisic acid signaling negatively regulates nitrate uptake via phosphorylation of NRT1.1 by SnRK2s in Arabidopsis. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 83-89 33331676-6 2021 Strikingly, SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1 (NRT1.1) in vitro and in vivo. Nitrates 76-83 nitrate transporter 1.1 Arabidopsis thaliana 96-118 33331676-6 2021 Strikingly, SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1 (NRT1.1) in vitro and in vivo. Nitrates 76-83 nitrate transporter 1.1 Arabidopsis thaliana 120-126 33331676-7 2021 The phosphorylation of NRT1.1 by SnRK2s resulted in a significant decrease of nitrate uptake and impairment of root growth. Nitrates 78-85 nitrate transporter 1.1 Arabidopsis thaliana 23-29 33686225-0 2021 A type 2C protein phosphatase activates high-affinity nitrate uptake by dephosphorylating NRT2.1. Nitrates 54-61 nitrate transporter 2:1 Arabidopsis thaliana 90-94 33686225-1 2021 The nitrate transporter NRT2.1, which plays a central role in high-affinity nitrate uptake in roots, is activated at the post-translational level in response to nitrogen (N) starvation1,2. Nitrates 4-11 nitrate transporter 2:1 Arabidopsis thaliana 24-28 33686225-3 2021 Here, we show that a type 2C protein phosphatase, designated CEPD-induced phosphatase (CEPH), activates high-affinity nitrate uptake by directly dephosphorylating Ser501 of NRT2.1, a residue that functions as a negative phospho-switch in Arabidopsis2. Nitrates 118-125 nitrate transporter 2:1 Arabidopsis thaliana 173-179 33637855-2 2021 Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Nitrates 229-236 nitrate transporter 1.1 Arabidopsis thaliana 193-199 33637855-2 2021 Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Nitrates 261-268 nitrate transporter 1.1 Arabidopsis thaliana 186-192 33637855-2 2021 Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots. Nitrates 261-268 nitrate transporter 1.1 Arabidopsis thaliana 193-199 33352382-4 2021 Firstly, an acclimation process was used: nitrate was progressively increased in three cultures set at pH 9, 10, or 11. Nitrates 42-49 phenylalanine hydroxylase Homo sapiens 103-105 33594566-1 2021 AD2 for efficient nitrate reduction without nitrite accumulation. Nitrates 18-25 apolipoprotein E Homo sapiens 0-3 33594566-6 2021 Results showed that strain AD2 removed 98.9% of nitrate-nitrogen (NO3--N) with an initial concentration about 100 mg L-1 in 48 h without nitrite-nitrogen (NO2--N) accumulation. Nitrates 48-55 apolipoprotein E Homo sapiens 27-30 33352382-10 2021 Finally, the use of long duration cultures with a highly alkaline pH allowed a nitrate reduction up to pH 11.5 with acetate. Nitrates 79-86 phenylalanine hydroxylase Homo sapiens 66-68 33352382-5 2021 This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate. Nitrates 50-57 phenylalanine hydroxylase Homo sapiens 74-76 33352382-10 2021 Finally, the use of long duration cultures with a highly alkaline pH allowed a nitrate reduction up to pH 11.5 with acetate. Nitrates 79-86 phenylalanine hydroxylase Homo sapiens 103-105 33352382-12 2021 Instead, bacteria used organic matter from inoculum to reduce nitrate at pH 11.5. Nitrates 62-69 phenylalanine hydroxylase Homo sapiens 73-75 33352382-5 2021 This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate. Nitrates 91-98 phenylalanine hydroxylase Homo sapiens 74-76 33352382-5 2021 This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate. Nitrates 91-98 phenylalanine hydroxylase Homo sapiens 74-76 33580260-3 2021 Different from most NRT1 transporters, NRT1.13 does not have the conserved proline residue between transmembrane domains 10 and 11; an essential residue for nitrate transport activity in CHL1/NRT1.1/NPF6.3. Nitrates 157-164 nitrate transporter 1.1 Arabidopsis thaliana 187-191 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 68-91 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 93-99 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 2:1 Arabidopsis thaliana 105-128 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 2:1 Arabidopsis thaliana 130-134 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 171-177 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 2:1 Arabidopsis thaliana 130-136 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 192-196 33643357-5 2021 An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate. Nitrates 47-54 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 286-303 33580260-3 2021 Different from most NRT1 transporters, NRT1.13 does not have the conserved proline residue between transmembrane domains 10 and 11; an essential residue for nitrate transport activity in CHL1/NRT1.1/NPF6.3. Nitrates 157-164 nitrate transporter 1.1 Arabidopsis thaliana 39-45 33580260-5 2021 However, when Ser 487 at the corresponding position was converted back to proline, NRT1.13 S487P regained nitrate uptake activity, suggesting that wild-type NRT1.13 cannot transport nitrate but can bind it. Nitrates 106-113 nitrate transporter 1.1 Arabidopsis thaliana 83-87 33580260-5 2021 However, when Ser 487 at the corresponding position was converted back to proline, NRT1.13 S487P regained nitrate uptake activity, suggesting that wild-type NRT1.13 cannot transport nitrate but can bind it. Nitrates 182-189 nitrate transporter 1.1 Arabidopsis thaliana 83-87 33560419-0 2021 Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity. Nitrates 25-32 SNF1 kinase homolog 10 Arabidopsis thaliana 7-14 33560419-0 2021 Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity. Nitrates 25-32 SLAC1 homologue 3 Arabidopsis thaliana 41-46 33560419-0 2021 Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity. Nitrates 58-65 SNF1 kinase homolog 10 Arabidopsis thaliana 7-14 33560419-0 2021 Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity. Nitrates 58-65 SLAC1 homologue 3 Arabidopsis thaliana 41-46 33560419-2 2021 Small amounts of NO3- can significantly mitigate ammonium toxicity, and the anion channel SLAC1 homologue 3 (SLAH3) is involved in this process, but the mechanistic detail of how SLAH3 regulates nitrate-dependent alleviation of ammonium toxicity is still largely unknown. Nitrates 195-202 SLAC1 homologue 3 Arabidopsis thaliana 90-107 33560419-2 2021 Small amounts of NO3- can significantly mitigate ammonium toxicity, and the anion channel SLAC1 homologue 3 (SLAH3) is involved in this process, but the mechanistic detail of how SLAH3 regulates nitrate-dependent alleviation of ammonium toxicity is still largely unknown. Nitrates 195-202 SLAC1 homologue 3 Arabidopsis thaliana 179-184 33560419-9 2021 Our study reveals that the C-terminal phosphorylation also plays important role in SLAH3 regulation and provides additional insights into nitrate-dependent alleviation of ammonium toxicity in plants. Nitrates 138-145 SLAC1 homologue 3 Arabidopsis thaliana 83-88 33398446-4 2021 We showed that the removal of nitrate in P. aeruginosa PAO1 was repressed by both the las and rhl systems. Nitrates 30-37 ATP-dependent RNA helicase RhlB Pseudomonas aeruginosa PAO1 94-97 33472361-4 2021 Increasing pH and/or decreasing oxygen promoted the conversion of nitrate (NO3-) into NO2- but suppressed the H2O2 formation, suggesting that there was a transition of radicals from oxidizing species like hydroxyl radicals to reducing species like hydrogen atoms and hydrated electrons. Nitrates 66-73 NBL1, DAN family BMP antagonist Homo sapiens 75-78 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 90-97 nitrate transporter 2:1 Arabidopsis thaliana 135-139 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 90-97 nitrate transporter 2:1 Arabidopsis thaliana 166-172 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 90-97 nitrate transporter 2.2 Arabidopsis thaliana 174-180 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 90-97 nitrate transporter 2:1 Arabidopsis thaliana 166-170 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 90-97 nitrate transporter 2:1 Arabidopsis thaliana 166-170 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 99-103 nitrate transporter 2:1 Arabidopsis thaliana 135-139 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 99-103 nitrate transporter 2:1 Arabidopsis thaliana 166-172 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 99-103 nitrate transporter 2.2 Arabidopsis thaliana 174-180 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 99-103 nitrate transporter 2:1 Arabidopsis thaliana 166-170 33582801-1 2021 In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 99-103 nitrate transporter 2:1 Arabidopsis thaliana 166-170 33257046-1 2021 A novel integrated bio-electrochemical system with sulfur autotrophic denitrification (SAD) and electrocoagulation (BESAD-EC) system was established to remove nitrate (NO3--N) and phosphorus from contaminated groundwater. Nitrates 159-166 NBL1, DAN family BMP antagonist Homo sapiens 168-171 33170463-9 2021 The bivariate plots of NO3 with other ions suggested that the principal origin of nitrate in this study is related to the excess application of fertilizers and sewages. Nitrates 82-89 NBL1, DAN family BMP antagonist Homo sapiens 23-26 33539179-1 2021 BACKGROUND: High levels of nitrate (NO3-) in drinking water cause methemoglobinemia in infants; however, few studies have examined the potential effects of low-level exposure on fetal growth, and the results have been inconsistent. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 36-39 32026170-7 2021 The groundwater quality of the Bathinda district is a matter of concern due to elevated levels of alkalinity, hardness, fluoride, uranium and nitrate (NO3-). Nitrates 142-149 NBL1, DAN family BMP antagonist Homo sapiens 151-154 32767561-1 2021 BACKGROUND: 3,4-dimethylpyrazole phosphate (DMPP) is a nitrification inhibitor which can restrict nitrate (NO3 - ) production. Nitrates 98-105 NBL1, DAN family BMP antagonist Homo sapiens 107-110 33399250-6 2021 This coordination is achieved by nitrate-dependent dephosphorylation of the PIN2 auxin efflux carrier at a previously uncharacterized phosphorylation site, leading to subsequent PIN2 lateralization and thereby regulating auxin flow between adjacent tissues. Nitrates 33-40 telomeric repeat binding factor 1 Homo sapiens 76-80 33399250-6 2021 This coordination is achieved by nitrate-dependent dephosphorylation of the PIN2 auxin efflux carrier at a previously uncharacterized phosphorylation site, leading to subsequent PIN2 lateralization and thereby regulating auxin flow between adjacent tissues. Nitrates 33-40 telomeric repeat binding factor 1 Homo sapiens 178-182 33487355-5 2021 In conclusion, NLP7 binds to the TAR2 promoter and activates TAR2 expression, thereby promoting nitrate-dependent LR development. Nitrates 96-103 trace amine associated receptor 2 Homo sapiens 33-37 33047410-4 2021 The delta15 N values are often lower in soil nitrate (NO3 - ) than in ammonium (NH4 + ) due to large isotopic fractionation during nitrification. Nitrates 45-52 NBL1, DAN family BMP antagonist Homo sapiens 54-57 33487355-5 2021 In conclusion, NLP7 binds to the TAR2 promoter and activates TAR2 expression, thereby promoting nitrate-dependent LR development. Nitrates 96-103 trace amine associated receptor 2 Homo sapiens 61-65 33367322-2 2021 In 1-3, the nearly planar molecular structures consisting of two DyIII ions and two L ligands are almost perpendicular to four nitrate ligands, which provides an opportunity to introduce auxiliary ligands (H2O or TPO) at the terminal position along the DyDy orientation of [Dy2]. Nitrates 127-134 thyroid peroxidase Homo sapiens 213-216 32840941-1 2021 RATIONALE: This study aims to develop a simplified denitrifier method for the delta15 N and delta18 O analysis of nitrate (NO3 - ) in natural water samples combining the method of Zhu et al [14] and the original denitrifier method of Sigman et al [12] . Nitrates 114-121 NBL1, DAN family BMP antagonist Homo sapiens 123-126 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 uncoupling protein 1 Rattus norvegicus 105-125 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 uncoupling protein 1 Rattus norvegicus 127-131 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 peroxisome proliferator-activated receptor gamma Rattus norvegicus 134-182 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 peroxisome proliferator-activated receptor gamma Rattus norvegicus 184-194 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 PPARG coactivator 1 alpha Rattus norvegicus 201-231 32950634-2 2021 This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D. Nitrates 52-59 PPARG coactivator 1 alpha Rattus norvegicus 233-243 32862077-2 2021 By analyzing the spectral absorption characteristics of nitrate, COD, and turbidity standard solutions and the mixtures of them, the absorption spectra in the range of 225-260 nm, 260-320 nm and 320-700 nm were selected as the characteristic spectra of nitrate, COD and turbidity, respectively. Nitrates 253-260 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 262-265 33432967-8 2021 While MET treatment reduced myocardial nitrates, only MET treatment completely restored microvessel dilation to dobutamine stimulation in the absence of NO and prostanoids (combined inhibition), indicating that MET restored the coronary flow reserve attributable to endothelium-derived hyperpolarisation. Nitrates 39-47 MET proto-oncogene, receptor tyrosine kinase Rattus norvegicus 6-9 33128338-0 2021 S-Nitrosylation of Akt by organic nitrate delays revascularization and the recovery of cardiac function in mice following myocardial infarction. Nitrates 34-41 thymoma viral proto-oncogene 1 Mus musculus 19-22 33297218-8 2021 In contrast, PAH degradation has been reported to increase up to 54% when nitrate is used as electron acceptor in low-temperature biochar-amended sediments. Nitrates 74-81 phenylalanine hydroxylase Homo sapiens 13-16 33128338-8 2021 In conclusion, long-term usage of organic nitrate may inactivate Akt to delay ischaemia-induced revascularization and the recovery of cardiac function through NO-mediated S-Nitrosylation. Nitrates 42-49 thymoma viral proto-oncogene 1 Mus musculus 65-68 33206969-6 2020 By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA. Nitrates 90-97 periplasmic nitrate reductase subunit alpha Agrobacterium fabrum str. C58 46-50 33270921-1 2021 Denitrifying woodchip bioreactors (DWBs) are potential low-cost technologies for the removal of nitrate (NO3 - ) in water through denitrification. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 105-108 33080433-10 2021 The resulting SECs for Kali river basin are: 2.03 (agricultural), 1.44 (fallow), and 0.92 (settlement) for monsoonal nitrate; while for non-monsoonal nitrate, SECs are 0.51 (agricultural), 0.23 (fallow), and 0.10 (settlement). Nitrates 117-124 SLAM family member 6 Homo sapiens 23-27 33080433-10 2021 The resulting SECs for Kali river basin are: 2.03 (agricultural), 1.44 (fallow), and 0.92 (settlement) for monsoonal nitrate; while for non-monsoonal nitrate, SECs are 0.51 (agricultural), 0.23 (fallow), and 0.10 (settlement). Nitrates 150-157 SLAM family member 6 Homo sapiens 23-27 33206969-6 2020 By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA. Nitrates 90-97 periplasmic nitrate reductase subunit alpha Agrobacterium fabrum str. C58 161-165 33048402-0 2020 NITROGEN RESPONSE DEFICIENCY 1 - mediated CHL1 induction contributes to optimized growth performance during altered nitrate availability in Arabidopsis. Nitrates 116-123 nitrate transporter 1.1 Arabidopsis thaliana 42-46 33374906-7 2020 Nitrate assimilation led to excessive ammonium accumulation in the shoot and lower nitrogen uptake, which exacerbated growth retardation of vha-a2 vha-a3. Nitrates 0-7 vacuolar proton ATPase A2 Arabidopsis thaliana 140-146 33374906-7 2020 Nitrate assimilation led to excessive ammonium accumulation in the shoot and lower nitrogen uptake, which exacerbated growth retardation of vha-a2 vha-a3. Nitrates 0-7 vacuolar proton ATPase A3 Arabidopsis thaliana 147-153 33183558-0 2020 Effect of a plant-based bioequivalent inorganic nitrate (NO3-) complex with vitamins, antioxidants and phytophenol rich food extracts in hypertensive individuals - A randomized, double-blind, placebo-controlled study. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 57-60 33183558-1 2020 BACKGROUND: This study assessed efficacy of plant based bioequivalent nitrate complex, consist of vitamins, natural antioxidants and phytophenol rich food extracts to elevate nitric oxide (NO) bioavailability as determined by saliva conversion of nitrate (NO3-) to nitrite (NO2-) a required step to produce NO, in relationship to lowering blood pressure (BP) in both men and women. Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 256-259 33169535-1 2020 Metallic Cu is a well-known electrocatalyst for nitrate reduction reaction (NO3 RR), but it suffers from relatively low activity, poor stability, and inducing nitrite accumulation during the long-term operation. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 76-79 33367898-4 2021 In Arabidopsis, the CIPK23 kinase has emerged as a major hub driving root responses to diverse environmental stresses including drought, salinity and nutrient imbalances such as potassium, nitrate and iron deficiencies as well as ammonium, magnesium and non-iron metals toxicities. Nitrates 189-196 CBL-interacting protein kinase 23 Arabidopsis thaliana 20-26 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 89-96 L1 cell adhesion molecule Homo sapiens 81-84 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 89-96 L1 cell adhesion molecule Homo sapiens 81-84 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 89-96 L1 cell adhesion molecule Homo sapiens 81-84 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 178-185 L1 cell adhesion molecule Homo sapiens 50-53 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 178-185 L1 cell adhesion molecule Homo sapiens 81-84 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 178-185 L1 cell adhesion molecule Homo sapiens 81-84 32854085-6 2020 Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved. Nitrates 178-185 L1 cell adhesion molecule Homo sapiens 81-84 33254675-6 2020 Isotope and NO3-/Cl- analysis indicated that nitrate in the subsidence area water (SAW) was mainly derived from chemical fertilizer (NF) and soil organic nitrogen (NS), while nitrate in the mainstream of the Huihe River water (HRW) was mainly derived from manure/sewage (MS). Nitrates 45-52 NBL1, DAN family BMP antagonist Homo sapiens 12-15 33048402-8 2020 We suggest that NID1 plays a crucial role as a transcription factor in optimizing plant growth by modulating the transcript abundance of the nitrate transceptor CHL1, leading to enhanced ABA accumulation in low-nitrate conditions. Nitrates 141-148 nitrate transporter 1.1 Arabidopsis thaliana 161-165 33048402-8 2020 We suggest that NID1 plays a crucial role as a transcription factor in optimizing plant growth by modulating the transcript abundance of the nitrate transceptor CHL1, leading to enhanced ABA accumulation in low-nitrate conditions. Nitrates 211-218 nitrate transporter 1.1 Arabidopsis thaliana 161-165 32907713-6 2020 We firstly found that NR activity was roughly positive-correlated with the root auxin level, and there is a crosstalk between nitrate signaling and auxin signaling. Nitrates 126-133 nitrate reductase 1 Arabidopsis thaliana 22-24 32785584-1 2020 Nitrification is the microbial conversion of reduced forms of nitrogen (N) to nitrate (NO3-), and in fertilized soils it can lead to substantial N losses via NO3- leaching or nitrous oxide (N2O) production. Nitrates 78-85 NBL1, DAN family BMP antagonist Homo sapiens 87-90 32933749-1 2020 NRT1.2 has been characterized as a low-affinity nitrate transporter and an abscisic acid (ABA) transporter in Arabidopsis. Nitrates 48-55 nitrate transporter 1:2 Arabidopsis thaliana 0-6 33329669-2 2020 Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation. Nitrates 114-121 cycling DOF factor 3 Arabidopsis thaliana 106-110 33329669-2 2020 Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation. Nitrates 114-121 cycling DOF factor 3 Arabidopsis thaliana 147-151 33329669-2 2020 Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation. Nitrates 174-181 cycling DOF factor 3 Arabidopsis thaliana 106-110 33329669-2 2020 Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation. Nitrates 174-181 cycling DOF factor 3 Arabidopsis thaliana 147-151 33329669-3 2020 Moreover, knockout cdf3 mutant plants exhibit nitrate-dependent lateral and primary root modifications, whereas CDF3 overexpression plants show increased biomass and enhanced root development under both nitrogen poor and rich conditions. Nitrates 46-53 cycling DOF factor 3 Arabidopsis thaliana 19-23 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 cycling DOF factor 3 Arabidopsis thaliana 28-32 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 cycling DOF factor 3 Arabidopsis thaliana 52-56 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 glutamate synthase 2 Arabidopsis thaliana 165-185 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 nitrate transporter 2:1 Arabidopsis thaliana 233-237 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 nitrate transporter 2:1 Arabidopsis thaliana 241-245 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 nitrate transporter 2:1 Arabidopsis thaliana 241-245 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 protein-serine kinase 1 Arabidopsis thaliana 302-305 33329669-4 2020 Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability. Nitrates 105-112 Pyridoxal phosphate phosphatase-related protein Arabidopsis thaliana 310-315 33329669-7 2020 These results highlight CDF3 as an important regulatory factor for the nitrate response, and its potential for improving N use efficiency in crops. Nitrates 71-78 cycling DOF factor 3 Arabidopsis thaliana 24-28 32463943-0 2020 NRT2.1 C-terminus phosphorylation prevents root high affinity nitrate uptake activity in Arabidopsis thaliana. Nitrates 62-69 nitrate transporter 2:1 Arabidopsis thaliana 0-6 33213070-11 2020 The patients that received Vit C had decreased levels of the nitrate and nitrite ratio (p < 0.01) and C-reactive protein levels (p = 0.04). Nitrates 61-68 vitrin Homo sapiens 27-30 33047961-4 2020 Deep nitrate storage varied from 43.6 to 1116.3 kg ha-1. Nitrates 5-12 Rho GTPase activating protein 45 Homo sapiens 51-55 32781362-1 2020 Batch experiments were conducted to test the hypothesis that nitrate (NO3-) could be immobilized by biochar via adsorption of CaNO3+ to the negatively charged biochar surfaces. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 33188441-4 2020 Sublingual nitrate may provide additional benefit to rectal NSAIDs in preventing PEP. Nitrates 11-18 prolyl endopeptidase Homo sapiens 81-84 33188441-8 2020 There is emerging data that aggressive hydration with lactated Ringer"s and nitrates may further reduce PEP. Nitrates 76-84 prolyl endopeptidase Homo sapiens 104-107 32463943-1 2020 In Arabidopsis thaliana, NRT2.1 codes for a main component of the root nitrate high-affinity transport system. Nitrates 71-78 nitrate transporter 2:1 Arabidopsis thaliana 25-29 32463943-2 2020 Previous studies revealed that post-translational regulation of NRT2.1 plays an important role in the control of root nitrate uptake and that one mechanism could correspond to NRT2.1 C-terminus processing. Nitrates 118-125 nitrate transporter 2:1 Arabidopsis thaliana 64-70 32463943-2 2020 Previous studies revealed that post-translational regulation of NRT2.1 plays an important role in the control of root nitrate uptake and that one mechanism could correspond to NRT2.1 C-terminus processing. Nitrates 118-125 nitrate transporter 2:1 Arabidopsis thaliana 64-68 32463943-7 2020 Finally, the relative level of serine 501 phosphorylation was found to be increased by ammonium nitrate in wild-type plants, leading to the inactivation of NRT2.1 and to a decrease in high affinity nitrate transport into roots. Nitrates 96-103 nitrate transporter 2:1 Arabidopsis thaliana 156-162 32870279-0 2020 NRT1.1-centered nitrate signaling in plants. Nitrates 16-23 nitrate transporter 1.1 Arabidopsis thaliana 0-6 33038483-15 2020 CONCLUSION: Bioactivation of NDOP involves functional XOR, and this new organic nitrate elicits vasorelaxation via NO-cGMP-PKG signaling and activation of KIR channels. Nitrates 80-87 xanthine dehydrogenase Rattus norvegicus 54-57 32870279-4 2020 NRT1.1 governs a wide range of responses to NO3-, from fast reprogramming of genome expression (the primary nitrate response) to longer-term developmental changes (effects on lateral root development). Nitrates 108-115 nitrate transporter 1.1 Arabidopsis thaliana 0-4 33036562-1 2020 BACKGROUND: High-affinity nitrate transporter 2 (NRT2) genes have been implicated in nitrate absorption and remobilization under nitrogen (N) starvation stress in many plant species, yet little is known about this gene family respond to various stresses often occurs in the production of rapeseed (Brassica napus L.). Nitrates 26-33 nitrate transporter 2:1 Arabidopsis thaliana 49-53 32854899-1 2020 Woodchip bioreactors are a practical, low-cost technology for reducing nitrate (NO3) loads discharged from agriculture. Nitrates 71-78 NBL1, DAN family BMP antagonist Homo sapiens 80-83 32686596-2 2020 We recently demonstrated that nitrate deficiency induces root coiling on horizontal surface through nitrate transporter/sensor NRT1.1 and PIN2- and AUX-mediated polar auxin transport. Nitrates 30-37 telomeric repeat binding factor 1 Homo sapiens 138-142 32870663-5 2020 Subsequent OH oxidation and direct photolysis both decompose the organic nitrates (ONs, representing bulk functionalities of NACs and organonitrates) in the NO3 -aged wood tar aerosols, thus decreasing the particle absorption. Nitrates 74-82 NBL1, DAN family BMP antagonist Homo sapiens 158-161 32686596-3 2020 Here, we show that nitrate deficiency or NRT1.1 loss-of-function induces differential distribution of PIN2 between the future concave and concave sides in root epidermal cells. Nitrates 19-26 telomeric repeat binding factor 1 Homo sapiens 102-106 32146561-6 2020 Nitrate concentrations ranged between 2.43 and 96 mg L-1. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 53-56 32146561-7 2020 Results indicated that nitrate temporal trend was increased significantly in most of the wells, and the spatial trend of area percentage of nitrate class 3 (not permissible limit of more than 50 mg L-1) was positive. Nitrates 140-147 immunoglobulin kappa variable 1-16 Homo sapiens 198-201 32377760-12 2020 Interestingly, PEDF levels were negatively correlated with plasma nitrite/nitrate levels and erectile function in DMED patients and STZ-induced diabetic rats. Nitrates 74-81 serpin family F member 1 Homo sapiens 15-19 33005412-7 2020 Higher concentrations of IL-6, TNF-alpha, IL-1beta, nitrite ( NO 2 - ) and nitrate ( NO 3 - ) and a lower concentration of IL-10 were observed in CD163-deficient mice treated with LPS. Nitrates 76-83 CD163 antigen Mus musculus 148-153 32959807-2 2020 It has been hypothesized that synthesis of oxidized nitrogen in the form of nitrate (NO3-) and nitrite (NO2-), occurred in the prebiotic anoxic Hadean atmosphere. Nitrates 76-83 NBL1, DAN family BMP antagonist Homo sapiens 85-88 32272331-1 2020 Sonochemical species such as nitrite (NO2-) and nitrate (NO3-) were detected in ultrapure aqueous medium with 28 kHz low frequency ultrasound (US) in the range of 200-1200 W output power. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 57-60 32878133-5 2020 In root tips, nitrate stimulated TaGS1;1, TaGS1;3, and TaGS2 expression in meristem, while NH4+ promoted tissue differentiation and TaGS1;2 expression in endodermis and vascular tissue. Nitrates 14-21 glutamine synthetase leaf isozyme, chloroplastic Triticum aestivum 55-60 32368787-8 2020 We hypothesized that maternal dietary nitrate administration would increase NO bioavailability to reduce systolic blood pressure (SBP), improve vascular function and increase fetal growth in pregnant endothelial NO synthase knockout (eNOS-/- ) mice, which exhibit hypertension, endothelial dysfunction and FGR. Nitrates 38-45 nitric oxide synthase 3, endothelial cell Mus musculus 234-238 32524996-0 2020 Dietary nitrate attenuated endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for NADPH oxidase. Nitrates 8-15 apolipoprotein E Mus musculus 74-90 32524996-4 2020 It was shown that dietary nitrate significantly attenuated aortic endothelial dysfunction and atherosclerosis in ApoE-/- mice. Nitrates 26-33 apolipoprotein E Mus musculus 113-117 32524996-5 2020 Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals. Nitrates 42-49 apolipoprotein E Mus musculus 163-167 32524996-5 2020 Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals. Nitrates 42-49 xanthine dehydrogenase Mus musculus 208-211 32524996-5 2020 Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals. Nitrates 42-49 apolipoprotein E Mus musculus 253-257 32524996-6 2020 These beneficial effects of nitrate in ApoE-/- mice were abolished by PTIO (NO scavenger) and significantly prevented by febuxostat (XOR inhibitor). Nitrates 28-35 apolipoprotein E Mus musculus 39-43 32524996-6 2020 These beneficial effects of nitrate in ApoE-/- mice were abolished by PTIO (NO scavenger) and significantly prevented by febuxostat (XOR inhibitor). Nitrates 28-35 xanthine dehydrogenase Mus musculus 133-136 32524996-9 2020 Altogether, boosting this nitrate-nitrite-NO signaling pathway resulted in the decreases of vascular NADPH oxidase-derived oxidative stress and endothelial dysfunction, and consequently protected ApoE-/- mice against atherosclerosis. Nitrates 26-33 apolipoprotein E Mus musculus 196-200 33124337-0 2020 [Quantification of Nitrate Sources to Groundwater in Karst Trough-valley Areas Based on Dual Stable Isotopes of delta15N-NO3- and delta18O-NO3- and the IsoSource Model]. Nitrates 19-26 NBL1, DAN family BMP antagonist Homo sapiens 121-124 33124337-0 2020 [Quantification of Nitrate Sources to Groundwater in Karst Trough-valley Areas Based on Dual Stable Isotopes of delta15N-NO3- and delta18O-NO3- and the IsoSource Model]. Nitrates 19-26 NBL1, DAN family BMP antagonist Homo sapiens 139-142 32759980-8 2020 These results suggest that nitrate ions are concentrated in the lacrimal glands by sialin and can be secreted into eye components via tears and then reduced to nitrite and NO, thereby being an important source of NO in the eye. Nitrates 27-34 solute carrier family 17 member 5 Homo sapiens 83-89 32843498-6 2020 The mechanism underlying the effects of nitrate on HFD-induced obesity was investigated by the following: the NO3 --NO2 --NO pathway; endothelial NO synthase (eNOS) and cyclic guanosine monophosphate (cGMP) levels; gut microbiota via 16SRNA analysis. Nitrates 40-47 NBL1, DAN family BMP antagonist Mus musculus 110-113 32339643-5 2020 To this regard research has shown that in addition to the classical NO synthase (NOS) dependent pathway, nitrate from our diet can work as an alternative precursor for NO and other bioactive nitrogen oxide species via serial reductions of nitrate (i.e. nitrate-nitrite-NO pathway). Nitrates 105-112 nitric oxide synthase 1 Homo sapiens 68-79 32843498-13 2020 CONCLUSIONS: Inorganic dietary nitrate alleviated HFD-induced obesity and ameliorated disrupted glucolipid metabolism via NO3 --NO2 --NO pathway activation and gut microbiome modulation. Nitrates 31-38 NBL1, DAN family BMP antagonist Mus musculus 122-125 32732239-1 2020 Annotated genomes of Caballeronia strains SBC1 and SBC2 from acidic permafrost suggest a new species with a facultative lifestyle via oxygen and nitrate respiration. Nitrates 145-152 solute carrier family 4 member 7 Homo sapiens 51-55 32449521-12 2020 Remarkably, dietary nitrate consumption attenuated and/or mitigated all these responses, including rendering mitochondria more coupled within BAT, and normalizing mitochondrial H2 O2 emission and insulin-mediated Akt-Thr308 phosphorylation within eWAT. Nitrates 20-27 thymoma viral proto-oncogene 1 Mus musculus 213-216 32732978-1 2020 Alpha-lipoic acid (alpha-LA), a well-known antioxidant, was proved to active ALDH2 in nitrate tolerance and diabetic animal model. Nitrates 86-93 aldehyde dehydrogenase 2, mitochondrial Mus musculus 77-82 32849729-4 2020 Contrarily, aseptically grown plants and axenic algal cells supplied with nitrate (NO3) are reported to emit N2O, indicating that it is produced inside plant cells by some unknown physiological phenomena. Nitrates 74-81 NBL1, DAN family BMP antagonist Homo sapiens 83-86 31832669-0 2020 NRT1.1 in plants: functions beyond nitrate transporter. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 0-6 31832669-1 2020 Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 12-20 31832669-1 2020 Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 27-35 31832669-1 2020 Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport. Nitrates 117-124 nitrate transporter 1.1 Arabidopsis thaliana 12-20 31832669-1 2020 Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport. Nitrates 117-124 nitrate transporter 1.1 Arabidopsis thaliana 27-35 31832669-2 2020 It is also found that AtNRT1.1 displays auxin transport activity and thus mediates nitrate-modulated root development, suggesting that it has transport capacities of multiple substrates. Nitrates 83-90 nitrate transporter 1.1 Arabidopsis thaliana 22-30 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 72-79 nitrate transporter 1.1 Arabidopsis thaliana 30-38 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 72-79 nitrate transporter 1.1 Arabidopsis thaliana 203-211 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 109-116 nitrate transporter 1.1 Arabidopsis thaliana 30-38 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 109-116 nitrate transporter 1.1 Arabidopsis thaliana 203-211 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 109-116 nitrate transporter 1.1 Arabidopsis thaliana 30-38 31832669-3 2020 Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing. Nitrates 109-116 nitrate transporter 1.1 Arabidopsis thaliana 203-211 31832669-4 2020 Recent studies further revealed how OsNRT1.1B, the functional homologue of AtNRT1.1 in rice, mediates the nitrate signal transduction from the plasma membrane to the nucleus, and how OsNRT1.1B integrates nitrate and phosphate signaling network. Nitrates 106-113 nitrate transporter 1.1 Arabidopsis thaliana 75-83 31832669-4 2020 Recent studies further revealed how OsNRT1.1B, the functional homologue of AtNRT1.1 in rice, mediates the nitrate signal transduction from the plasma membrane to the nucleus, and how OsNRT1.1B integrates nitrate and phosphate signaling network. Nitrates 204-211 nitrate transporter 1.1 Arabidopsis thaliana 75-83 32133500-5 2020 ZmTMM1 belongs to the AGL17-like MADS-box transcription factor family that contains orthologs of ANR1, a key regulator for root nitrate foraging in Arabidopsis. Nitrates 128-135 AGAMOUS-like 17 Arabidopsis thaliana 22-27 32133500-5 2020 ZmTMM1 belongs to the AGL17-like MADS-box transcription factor family that contains orthologs of ANR1, a key regulator for root nitrate foraging in Arabidopsis. Nitrates 128-135 AGAMOUS-like 44 Arabidopsis thaliana 97-101 32206788-2 2020 In plants, nitrogen (N) source for uptake and assimilation, mainly in the forms of nitrate (NO3-) and ammonium (NH4+) quantitatively dominates the anion and cation equilibrium and the pH balance in cells. Nitrates 83-90 NBL1, DAN family BMP antagonist Homo sapiens 92-95 32428238-0 2020 The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate. Nitrates 132-139 nitrate transporter 1.1 Arabidopsis thaliana 16-20 32428238-3 2020 In Arabidopsis, the NRT1.1 nitrate transceptor represses lateral root (LR) development at low nitrate availability by promoting auxin basipetal transport out of the LR primordia (LRPs). Nitrates 27-34 nitrate transporter 1.1 Arabidopsis thaliana 20-26 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 72-79 nitrate transporter 1.1 Arabidopsis thaliana 5-11 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 72-79 tryptophan aminotransferase related 2 Arabidopsis thaliana 35-39 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 72-79 like AUX1 3 Arabidopsis thaliana 44-48 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 72-79 tryptophan aminotransferase related 2 Arabidopsis thaliana 132-136 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 72-79 like AUX1 3 Arabidopsis thaliana 141-145 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 nitrate transporter 1.1 Arabidopsis thaliana 5-11 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 tryptophan aminotransferase related 2 Arabidopsis thaliana 35-39 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 like AUX1 3 Arabidopsis thaliana 44-48 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 tryptophan aminotransferase related 2 Arabidopsis thaliana 132-136 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 like AUX1 3 Arabidopsis thaliana 141-145 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 nitrate transporter 1.1 Arabidopsis thaliana 5-11 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 tryptophan aminotransferase related 2 Arabidopsis thaliana 35-39 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 like AUX1 3 Arabidopsis thaliana 44-48 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 tryptophan aminotransferase related 2 Arabidopsis thaliana 132-136 32428238-7 2020 Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate. Nitrates 111-118 like AUX1 3 Arabidopsis thaliana 141-145 32428238-8 2020 Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required for LRP development, and as a consequence that NRT1.1 plays a much more integrated role than previously anticipated in regulating the nitrate response of root system architecture. Nitrates 269-276 nitrate transporter 1.1 Arabidopsis thaliana 42-48 32428238-8 2020 Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required for LRP development, and as a consequence that NRT1.1 plays a much more integrated role than previously anticipated in regulating the nitrate response of root system architecture. Nitrates 269-276 nitrate transporter 1.1 Arabidopsis thaliana 182-188 32663212-8 2020 Mean nitrate leaching rates for the years 2005-2017 were 9.4 kg N ha-1 yr-1, ranging from 0.04 to 53 kg N ha-1 yr-1. Nitrates 5-12 solute carrier family 9 member B1 Homo sapiens 64-75 32765562-1 2020 As an important nitrogen source, nitrate (NO3 -) absorbed by plants is carried throughout the plant via short-distance distribution (cytoplasm to vacuole) and long-distance transportation (root to shoot), the two pathways that jointly regulate the content of NO3 - in plants. Nitrates 33-40 NBL1, DAN family BMP antagonist Homo sapiens 42-45 32765562-1 2020 As an important nitrogen source, nitrate (NO3 -) absorbed by plants is carried throughout the plant via short-distance distribution (cytoplasm to vacuole) and long-distance transportation (root to shoot), the two pathways that jointly regulate the content of NO3 - in plants. Nitrates 33-40 NBL1, DAN family BMP antagonist Homo sapiens 259-262 32267563-1 2020 RATIONALE: The nitrogen isotopic ratio of nitrate (delta15 N-NO3 - value) is a critical parameter to understand nitrogen biogeochemical cycling in aquatic systems. Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 61-64 32646062-7 2020 Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNFalpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins. Nitrates 14-21 tumor necrosis factor Homo sapiens 110-118 32650602-9 2020 The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels. Nitrates 145-152 inositol-3-phosphate synthase 1 Homo sapiens 66-70 32646062-7 2020 Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNFalpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins. Nitrates 14-21 intercellular adhesion molecule 1 Homo sapiens 120-125 32583581-5 2020 An impressive removal capacity as high as 22 500 mg N g-1 CuPd ( 12 times superior to Fe-based catalysts), high nitrate conversion (>95%) and nitrogen selectivity (>95%) are achieved under a low initial concentration of nitrate (100 mg L-1 ) when using an optimized-NRR electrocatalyst (4CuPd@DCL-MCS/CNTs). Nitrates 220-227 L1 cell adhesion molecule Homo sapiens 236-239 32247143-1 2020 It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply. Nitrates 47-54 NBL1, DAN family BMP antagonist Homo sapiens 56-59 32247143-1 2020 It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply. Nitrates 47-54 NBL1, DAN family BMP antagonist Homo sapiens 160-163 32583581-6 2020 Remarkably, nitrate conversion and nitrogen selectivity are both close to 100% in an ultralow concentration of 10 mg L-1 , meeting drinking water standard. Nitrates 12-19 L1 cell adhesion molecule Homo sapiens 117-120 32222508-1 2020 Woodchip bioreactors are viable low-cost nitrate (NO3-) removal applications for treating agricultural and aquaculture discharges. Nitrates 41-48 NBL1, DAN family BMP antagonist Homo sapiens 50-53 32213401-5 2020 Among these, all membranes removed chloride but only NF97 and NF90 were able to remove nitrate in compliance with Chilean drinking water standard, showing rejections of 97% and 87%, respectively, in an optimum pressure range of 12-20 bar in which the NF90 produced 3.5 times more permeated water than NF97. Nitrates 87-94 interleukin enhancer binding factor 3 Homo sapiens 62-66 32110844-3 2020 We thus developed a new method to measure delta15 N-NO3 - values in a saline sample with low nitrate concentration by improving the acetone method (the adapted method) and verified tits usability. Nitrates 93-100 NBL1, DAN family BMP antagonist Homo sapiens 52-55 32574223-1 2020 PURPOSE: Nitrate (NO3-), through its conversion to nitrite (NO2-) and nitric oxide, has been shown to increase exercise tolerance in healthy younger adults and older diseased patients. Nitrates 9-16 NBL1, DAN family BMP antagonist Homo sapiens 18-21 32612583-1 2020 Understanding the biogeochemical controls on the partitioning between nitrogen (N) removal through denitrification and anaerobic ammonium oxidation (anammox), and N recycling via dissimilatory nitrate (NO3 -) reduction to ammonium (DNRA) is crucial for constraining lacustrine N budgets. Nitrates 193-200 NBL1, DAN family BMP antagonist Homo sapiens 202-205 32537558-9 2020 Finally, we demonstrated that the AtGRXS8 protein can physically interact with the TGA1 and TGA4 transcription factors, which are central regulators of early transcriptional responses to nitrate in A. thaliana roots. Nitrates 187-194 TGACG motif-binding factor 4 Arabidopsis thaliana 92-96 32537558-10 2020 Overall, these results suggest that AtGRXS8 acts to quench both transcriptional and developmental aspects of primary nitrate response, potentially by interfering with the activity of the TGA1 and TGA4 transcription factors. Nitrates 117-124 bZIP transcription factor family protein Arabidopsis thaliana 187-191 32537558-9 2020 Finally, we demonstrated that the AtGRXS8 protein can physically interact with the TGA1 and TGA4 transcription factors, which are central regulators of early transcriptional responses to nitrate in A. thaliana roots. Nitrates 187-194 bZIP transcription factor family protein Arabidopsis thaliana 83-87 32537558-10 2020 Overall, these results suggest that AtGRXS8 acts to quench both transcriptional and developmental aspects of primary nitrate response, potentially by interfering with the activity of the TGA1 and TGA4 transcription factors. Nitrates 117-124 TGACG motif-binding factor 4 Arabidopsis thaliana 196-200 32523127-7 2020 Along with the transcriptional upregulation of NLPs, genotype IR-3-1-1, displayed highest expression of OsNRT1.1B gene, the closest rice homologue of nitrate transceptor AtNRT1.1 and plays major role in nitrate uptake, translocation and signaling in rice. Nitrates 203-210 nitrate transporter 1.1 Arabidopsis thaliana 170-178 32523127-8 2020 The results showed that high NUE rice genotypes has both high Nitrogen uptake efficiency (NUpE) and Nitrogen utilization efficiency (NUtE), resulting from the effective and coordinated signal transduction network involving the rice homologue of nitrate transceptor OsNRT1.1B, the probable primary nitrate response (PNR) regulator OsNLP1 and the master response regulator OsNLP3, a homologue of AtNLP6/7. Nitrates 245-252 Plant regulator RWP-RK family protein Arabidopsis thaliana 394-402 32302589-5 2020 We identified the LGO gene, a CDK inhibitor, as a key cell cycle regulatory factor influencing ploidy and cell-size depending on external nitrate. Nitrates 138-145 LOSS OF GIANT CELLS FROM ORGANS Arabidopsis thaliana 18-21 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 32-39 nitrate transporter 1.1 Arabidopsis thaliana 98-104 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 32-39 nitrate transporter 2:1 Arabidopsis thaliana 109-113 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 41-45 nitrate transporter 1.1 Arabidopsis thaliana 98-104 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 41-45 nitrate transporter 2:1 Arabidopsis thaliana 109-113 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 77-84 nitrate transporter 1.1 Arabidopsis thaliana 98-104 32526869-2 2020 One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants. Nitrates 77-84 nitrate transporter 2:1 Arabidopsis thaliana 109-113 32526869-3 2020 Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes. Nitrates 52-59 nitrate transporter 1.1 Arabidopsis thaliana 0-23 32526869-3 2020 Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes. Nitrates 52-59 nitrate transporter 1.1 Arabidopsis thaliana 25-31 32526869-3 2020 Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes. Nitrates 211-218 nitrate transporter 1.1 Arabidopsis thaliana 0-23 32526869-3 2020 Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes. Nitrates 211-218 nitrate transporter 1.1 Arabidopsis thaliana 25-31 32302589-6 2020 Nitrate induces LGO gene expression as early as 3 days after germination in epidermal and mesophyll cell layers, which undergo endoreplication to increment DNA content and cell size. Nitrates 0-7 LOSS OF GIANT CELLS FROM ORGANS Arabidopsis thaliana 16-19 32124508-1 2020 The balance between nitrate respiration pathways, denitrification and dissimilatory nitrate (NO3 - ) reduction to ammonium (DNRA), determines whether bioavailable nitrogen is removed as N2 gas or recycled as ammonium. Nitrates 84-91 NBL1, DAN family BMP antagonist Homo sapiens 93-96 32514747-5 2020 The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters. Nitrates 269-276 serine/threonine-protein kinase SAPK2 Oryza sativa Japonica Group 121-126 32514747-5 2020 The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters. Nitrates 330-337 serine/threonine-protein kinase SAPK2 Oryza sativa Japonica Group 121-126 32514747-5 2020 The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters. Nitrates 330-337 serine/threonine-protein kinase SAPK2 Oryza sativa Japonica Group 121-126 32582237-0 2020 NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport. Nitrates 16-23 nitrate transporter 1.1 Arabidopsis thaliana 0-6 32582237-0 2020 NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport. Nitrates 16-23 Auxin efflux carrier family protein Arabidopsis thaliana 62-66 32582237-0 2020 NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport. Nitrates 16-23 Transmembrane amino acid transporter family protein Arabidopsis thaliana 72-76 32582237-6 2020 Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1). Nitrates 0-7 Auxin efflux carrier family protein Arabidopsis thaliana 133-144 32582237-6 2020 Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1). Nitrates 0-7 Auxin efflux carrier family protein Arabidopsis thaliana 146-150 32582237-6 2020 Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1). Nitrates 0-7 Transmembrane amino acid transporter family protein Arabidopsis thaliana 156-173 32582237-6 2020 Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1). Nitrates 0-7 Transmembrane amino acid transporter family protein Arabidopsis thaliana 175-179 32582237-7 2020 We further show that suppression of ARG by nitrate is mediated by the nitrate transporter/sensor NRT1.1. Nitrates 43-50 nitrate transporter 1.1 Arabidopsis thaliana 97-103 32582237-8 2020 In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG. Nitrates 81-88 Auxin efflux carrier family protein Arabidopsis thaliana 13-17 32582237-8 2020 In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG. Nitrates 81-88 Transmembrane amino acid transporter family protein Arabidopsis thaliana 23-27 32582237-8 2020 In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG. Nitrates 81-88 nitrate transporter 1.1 Arabidopsis thaliana 71-77 32157271-0 2020 Arabidopsis chloroplast J protein DJC75/CRRJ mediates nitrate-promoted seed germination in the dark. Nitrates 54-61 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 34-39 32157271-0 2020 Arabidopsis chloroplast J protein DJC75/CRRJ mediates nitrate-promoted seed germination in the dark. Nitrates 54-61 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 40-44 32157271-2 2020 Here, we show that a plastid J-domain protein DJC75/CRRJ in Arabidopsis (Arabidopsis thaliana) is important for nitrate-promoted seed germination in the dark. Nitrates 112-119 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 46-51 32157271-2 2020 Here, we show that a plastid J-domain protein DJC75/CRRJ in Arabidopsis (Arabidopsis thaliana) is important for nitrate-promoted seed germination in the dark. Nitrates 112-119 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 52-56 32157271-4 2020 The seed germination rate of mutants defective in DJC75 was determined in the presence of nitrate when light cues for seed germination were eliminated by the treatment of imbibed seeds with a pulse of far-red light to inactivate phyB, or by assaying germination in the dark with seeds harboring the phyB mutation. Nitrates 90-97 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 50-55 32157271-7 2020 Mutants defective in DJC75 showed seed germination defects in the presence of nitrate when light cues for seed germination were eliminated. Nitrates 78-85 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 21-26 32157271-9 2020 Upregulation of GA biosynthetic gene GA3ox1 expression by nitrate in imbibed phyB mutant seeds was diminished when DJC75 was knocked-out. Nitrates 58-65 gibberellin 3-oxidase 1 Arabidopsis thaliana 37-43 32157271-9 2020 Upregulation of GA biosynthetic gene GA3ox1 expression by nitrate in imbibed phyB mutant seeds was diminished when DJC75 was knocked-out. Nitrates 58-65 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 115-120 32157271-10 2020 CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination. Nitrates 76-83 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 60-65 32157271-10 2020 CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination. Nitrates 76-83 gibberellin 3-oxidase 1 Arabidopsis thaliana 178-184 32157271-10 2020 CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination. Nitrates 76-83 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 223-228 32157271-10 2020 CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination. Nitrates 285-292 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 60-65 32157271-11 2020 DJC75 is the first pathway component identified for nitrate-promoted seed germination in the dark. Nitrates 52-59 Chaperone DnaJ-domain superfamily protein Arabidopsis thaliana 0-5 31342638-0 2020 Phosphorylation at Ser28 stabilizes the Arabidopsis nitrate transporter NRT2.1 in response to nitrate limitation. Nitrates 52-59 nitrate transporter 2:1 Arabidopsis thaliana 72-78 32300065-6 2020 The lower arterial pressure and enhanced natriuresis during high salt loading in Pkd1 knockout mice were associated with lower urinary nitrite/nitrate excretion and markedly increased urinary PGE2 excretion, whereas GFR, plasma renin concentration, and urinary endothelin-1 excretion were similar between knockout and control mice. Nitrates 143-150 polycystin 1, transient receptor potential channel interacting Mus musculus 81-85 31342638-9 2020 These results demonstrate that phosphorylation at Ser28 is crucial for NRT2.1 protein stabilization and accumulation in response to nitrate limitation. Nitrates 132-139 nitrate transporter 2:1 Arabidopsis thaliana 71-77 31342638-3 2020 Nitrate transporter 2.1 (NRT2.1) is the major component of the root high-affinity nitrate transport system in Arabidopsis thaliana. Nitrates 82-89 nitrate transporter 2:1 Arabidopsis thaliana 0-23 31342638-3 2020 Nitrate transporter 2.1 (NRT2.1) is the major component of the root high-affinity nitrate transport system in Arabidopsis thaliana. Nitrates 82-89 nitrate transporter 2:1 Arabidopsis thaliana 25-29 31342638-6 2020 When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1. Nitrates 35-42 nitrate transporter 2:1 Arabidopsis thaliana 89-95 31342638-6 2020 When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1. Nitrates 35-42 nitrate transporter 2:1 Arabidopsis thaliana 152-158 31342638-6 2020 When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1. Nitrates 35-42 nitrate transporter 2:1 Arabidopsis thaliana 152-158 32317363-1 2020 The interaction of C-Terminally Encoded Peptides (CEPs) with CEP RECEPTOR 1 (CEPR1) controls root growth and development, as well as nitrate uptake, but has no known role in determining yield. Nitrates 133-140 Leucine-rich repeat transmembrane protein kinase family protein Arabidopsis thaliana 77-82 32801436-11 2020 Conclusion: EECP-therapy decreased the expression of TLR2 on peripheral monocytes in patients with chronic stable refractory angina which yield improvement in the quality of patients" life by decreasing the frequency of angina episodes, decreasing the Short-acting nitrate use and change the exercise tolerance and distance. Nitrates 265-272 toll like receptor 2 Homo sapiens 53-57 32466182-0 2020 Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway. Nitrates 18-25 matrix metallopeptidase 9 Homo sapiens 64-90 32550602-3 2020 Few reports described the simultaneous formation of ammonia (NH4 +) and nitrate (NO3 -) by a photocatalytic reaction and the related mechanism. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 32528483-1 2020 Chloride (Cl-) has traditionally been considered harmful to agriculture because of its toxic effects in saline soils and its antagonistic interaction with nitrate (NO3 -), which impairs NO3 - nutrition. Nitrates 155-162 NBL1, DAN family BMP antagonist Homo sapiens 164-167 32528483-1 2020 Chloride (Cl-) has traditionally been considered harmful to agriculture because of its toxic effects in saline soils and its antagonistic interaction with nitrate (NO3 -), which impairs NO3 - nutrition. Nitrates 155-162 NBL1, DAN family BMP antagonist Homo sapiens 186-189 32466182-2 2020 Barbiturate nitrate hybrid compounds have been designed to inhibit MMP secretion and enzyme activity. Nitrates 12-19 matrix metallopeptidase 1 Homo sapiens 67-70 31231758-3 2020 We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3- nitrite (NO2 ) NO enterosalivary pathway, could increase muscle contractile function in older subjects. Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 48-51 31231758-3 2020 We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3- nitrite (NO2 ) NO enterosalivary pathway, could increase muscle contractile function in older subjects. Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 78-81 32105927-1 2020 Accurate identification of nitrate (NO3-) sources is critical to address the issue of groundwater pollution. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 36-39 31811920-10 2020 Moreover, microbiota analysis revealed that nitrate could partially decrease the enriched metabolic pathways (p53 signaling pathway and colorectal cancer pathway) compared with that in the DSS and DSS + NaCl groups. Nitrates 44-51 tumor protein p53 Homo sapiens 110-113 32250790-1 2020 Stream and riparian zone networks embedded in agricultural landscapes provide a potential intervention point to ameliorate the negative effects of agricultural runoff by reducing transport of nitrate (NO3-) and suspended sediments (SS) downstream. Nitrates 192-199 NBL1, DAN family BMP antagonist Homo sapiens 201-204 32092511-1 2020 Sediment denitrification (DEN), anaerobic ammonium oxidation (Anammox), and dissimilatory nitrate reduction to ammonium (DNRA) are three important nitrate (NO3-) reduction pathways in aquatic ecosystems. Nitrates 90-97 NBL1, DAN family BMP antagonist Homo sapiens 156-159 32092511-1 2020 Sediment denitrification (DEN), anaerobic ammonium oxidation (Anammox), and dissimilatory nitrate reduction to ammonium (DNRA) are three important nitrate (NO3-) reduction pathways in aquatic ecosystems. Nitrates 147-154 NBL1, DAN family BMP antagonist Homo sapiens 156-159 32250815-2 2020 This could lead to increased nitrate (NO3-) leaching when water scarcity affects the N-uptake capacity of trees and increases soil N availability due to early leaf senescence and higher litter input. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 38-41 32086288-7 2020 Mechanistically, we determine that nitrate induces these phenotypic changes in primary adipocytes through the xanthine oxidoreductase catalysed reduction of nitrate to nitric oxide and independently of Peroxisome Proliferator-Activated Receptor alpha. Nitrates 35-42 xanthine dehydrogenase Rattus norvegicus 110-133 32062279-7 2020 The relationships between mass fractions of SO42- and NO3- in those ranges of different alkaline metal ion content also suggested that alkaline metal ions participate in the competing neutralization reaction of sulfate and nitrate. Nitrates 223-230 NBL1, DAN family BMP antagonist Homo sapiens 54-57 32070893-1 2020 Nitrate (NO3-) contamination in groundwater is an environmental problem worldwide. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 32070893-9 2020 Nitrate in groundwater in industrial areas has different pattern of the proportional contribution, in which groundwater NO3- is largely influenced by sewage discharge and atmospheric precipitation. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 120-123 32393171-10 2020 Notably, we found a transcription factor ZmNLP6, a homolog of AtNLP7-a well-known regulator for N-response and root growth-generates several isoforms varied in capacities of activating downstream targets specifically after nitrate supply. Nitrates 223-230 NIN like protein 7 Arabidopsis thaliana 62-68 32086288-7 2020 Mechanistically, we determine that nitrate induces these phenotypic changes in primary adipocytes through the xanthine oxidoreductase catalysed reduction of nitrate to nitric oxide and independently of Peroxisome Proliferator-Activated Receptor alpha. Nitrates 157-164 xanthine dehydrogenase Rattus norvegicus 110-133 31506874-8 2020 Other trace elements are aluminum-30%, arsenic-10%, and nitrate (NO3)-10%, and they are examples of elements which have above MAC for drinking water. Nitrates 56-63 NBL1, DAN family BMP antagonist Homo sapiens 65-68 32067475-1 2020 Nitrate (NO3-) sources and discharge were investigated using isotope and hydrochemical analyses in three river catchments draining Lake Victoria basin, Kenya. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 32316351-1 2020 In this paper, an all-solid-state nitrate doped polypyrrole (PPy(NO3-) ion-selective electrode (ISE) was prepared with a nanohybrid composite film of gold nanoparticles (AuNPs) and electrochemically reduced graphene oxide (ERGO). Nitrates 34-41 NBL1, DAN family BMP antagonist Homo sapiens 65-68 32172966-1 2020 Excessive nitrate (NO3-) is among the most problematic surface water and groundwater pollutants. Nitrates 10-17 NBL1, DAN family BMP antagonist Homo sapiens 19-22 31811679-0 2020 Nitrate-inducible NIGT1 Proteins Modulate Phosphate Uptake and Starvation Signaling via Transcriptional Regulation of SPX Genes. Nitrates 0-7 spexin hormone Homo sapiens 118-121 31811679-6 2020 Furthermore, protoplast-based transient expression assay and chromatin immunoprecipitation assay demonstrate that NIGT1 GARP-type transcriptional repressors, which are encoded by nitrate-inducible genes, directly bind to and repress the promoters of genes encoding SPX proteins. Nitrates 179-186 cyclic nucleotide gated channel subunit beta 1 Homo sapiens 120-124 31811679-6 2020 Furthermore, protoplast-based transient expression assay and chromatin immunoprecipitation assay demonstrate that NIGT1 GARP-type transcriptional repressors, which are encoded by nitrate-inducible genes, directly bind to and repress the promoters of genes encoding SPX proteins. Nitrates 179-186 spexin hormone Homo sapiens 265-268 31811679-7 2020 Consistent with the role of SPX proteins in the suppression of the PHR1 transcriptional activator, the master regulator for phosphate starvation responses, nitrate-dependent enhancement of phosphate starvation responses, such as accumulation of anthocyanin and promotion of root hair growth and phosphate uptake, was less evident in the nigt1.1-nigt1.4 quadruple mutant. Nitrates 156-163 spexin hormone Homo sapiens 28-31 31811679-7 2020 Consistent with the role of SPX proteins in the suppression of the PHR1 transcriptional activator, the master regulator for phosphate starvation responses, nitrate-dependent enhancement of phosphate starvation responses, such as accumulation of anthocyanin and promotion of root hair growth and phosphate uptake, was less evident in the nigt1.1-nigt1.4 quadruple mutant. Nitrates 156-163 pleckstrin homology domain containing B1 Homo sapiens 67-71 32097807-2 2020 After 140 days" enrichment, the nitrate removal rate increased significantly from 3 to 4 mg-N L-1 d-1 to 22.09 +- 1.21 mg-N L-1 d-1 and the indicator, mol CH4 consumed/mol reduced NO3--N (C/N ratio), decreased to 1.79 which was very close to the theoretical minimum value (1.27-1.39). Nitrates 32-39 NBL1, DAN family BMP antagonist Homo sapiens 180-183 31981873-2 2020 The oxygen-17 excess of nitrate (Delta17O(NO3-)) can be used to reveal the relative importance of nitrate formation pathways and get more insight into reactive nitrogen chemistry. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 42-45 31981873-2 2020 The oxygen-17 excess of nitrate (Delta17O(NO3-)) can be used to reveal the relative importance of nitrate formation pathways and get more insight into reactive nitrogen chemistry. Nitrates 98-105 NBL1, DAN family BMP antagonist Homo sapiens 42-45 31981873-6 2020 Delta17O(NO3-)-constrained estimates suggest that the conversion of NOX to nitrate is dominated by NO2 + OH and/or NO2 + H2O, with the mean possible contribution of 55-77% in total and even higher (84-92%) in summer. Nitrates 75-82 NBL1, DAN family BMP antagonist Homo sapiens 9-12 32608665-4 2020 The results show that approximately 7.83% of rivers in China exceeded the Chinese drinking water standard for nitrate (45 mg L-1). Nitrates 110-117 L1 cell adhesion molecule Homo sapiens 125-128 32064956-4 2020 Also, prolactin markedly reduces the increased levels of the neurotransmitters (gamma-aminobutyric acid and glutamate), cerebral calcium and nitrate in different brain compartments of ischemic rats.Conclusion: Prolactin is able to ameliorate ischemia-reperfusion injury in rat brain and might be a potent candidate for further neuro-therapeutics development. Nitrates 141-148 prolactin Rattus norvegicus 6-15 32007629-6 2020 RESULTS: There was a strong positive correlation between urinary nitrate clearance and eGFR, (Spearman R = 0.7665, p < 0.0001) with a moderate negative correlation between plasma nitrate concentration and CKD-EPI eGFR, (Spearman"s R = -0.37, p = 0.012). Nitrates 65-72 epidermal growth factor receptor Homo sapiens 87-91 32126767-4 2020 In contrast to the previous view of weak winter photochemistry, we show that the O3 and OH productions are sufficiently high in winter to facilitate fast gas-phase and heterogeneous conversion of NOX to nitrate over the NCP. Nitrates 203-210 immunoglobulin kappa variable 2D-38 (pseudogene) Homo sapiens 81-90 32126767-5 2020 Increasing O3 and OH productions from higher precursor levels and fast ROX cycling accelerate the nitrate generation during heavy pollution. Nitrates 98-105 immunoglobulin kappa variable 2D-38 (pseudogene) Homo sapiens 11-20 32126767-5 2020 Increasing O3 and OH productions from higher precursor levels and fast ROX cycling accelerate the nitrate generation during heavy pollution. Nitrates 98-105 MAX network transcriptional repressor Homo sapiens 71-74 32120180-7 2020 In nitrate-taking patients, serum complement C1q had a negative association with Gensini score (r=-0.275, P = 0.001), and in non-smokers, there was also a negative correlation (beta=-0.159, P = 0.036). Nitrates 3-10 complement C1q A chain Homo sapiens 45-48 32007629-7 2020 There was a trend between fractional excretion of nitrate and CKD-EPI eGFR (ml/min/1.73 m2) Spearman"s R 0.27, p = 0.07 though this did not reach statistical significance. Nitrates 50-57 epidermal growth factor receptor Homo sapiens 70-74 32148171-7 2021 The treated effluent that received 20% of leachate showed 2.7 mg L-1 ammonia and 1.1 mg L-1 nitrate. Nitrates 92-99 L1 cell adhesion molecule Homo sapiens 88-91 31793100-3 2020 Predominantly expressed and accumulated in roots and vascular tissues, ZmNLP5 was shown to rapidly respond to nitrate treatment. Nitrates 110-117 Protein RKD4 Zea mays 71-77 31793100-4 2020 Under limited N supply, compared with that of wild-type (WT) seedlings, the zmnlp5 mutant seedlings accumulated less nitrate and nitrite in the root tissues and ammonium in the shoot tissues. Nitrates 117-124 Protein RKD4 Zea mays 76-82 31793100-6 2020 Furthermore, the mutants carrying the transgenic ZmNLP5 cDNA fragment significantly increased the nitrate content in the root tissues compared with that of the zmnlp5 mutants. Nitrates 98-105 Protein RKD4 Zea mays 49-55 31793100-8 2020 We further show that ZmNLP5 directly regulates the expression of nitrite reductase 1.1 (ZmNIR1.1) by binding to the nitrate-responsive cis-element (NRE) at the 5" UTR of the gene. Nitrates 116-123 Protein RKD4 Zea mays 21-27 32118414-1 2020 Electrochemical conversion of nitrate (NO3-) into ammonia (NH3) recycles nitrogen and offers a route to the production of NH3, which is more valuable than dinitrogen gas. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 39-42 32187974-6 2020 Our results suggest that nitrate dual-isotope was very useful for tracing the main NO3- sources in the condition of the sufficient ammonium, and runoff exerted an important impact on the shift in NO3- sources between both the local source and the source from the upper river basin during the two seasons in this monsoon-controlled bay. Nitrates 25-32 NBL1, DAN family BMP antagonist Homo sapiens 83-86 31929050-4 2020 The ratio of the first-order rate coefficient of fumarate to nitrate (k1,fum/k1,NO3) was obtained to estimate the amount and frequency of fumarate injection for the effective design of WDB. Nitrates 61-68 keratin 1 Homo sapiens 77-83 31951900-9 2020 Only NIA1 was detected in roots and its expression, together with NR activity and nitrates levels, was the highest in N medium devoid of Cd. Nitrates 82-90 nitrate reductase 1 Arabidopsis thaliana 5-9 32608629-5 2020 The total annual runoff in the Shipanqiu small watershed was 8.02x104 m3, and the annual total nitrogen loss flux was 5.04 kg hm-2, of which nitrate nitrogen (2.54 kg hm-2) was the main part. Nitrates 141-148 cholinergic receptor muscarinic 2 Homo sapiens 167-171 31875569-1 2020 Nitrate (NO3-) affected perchlorate (ClO4-) reduction in a membrane batch biofilm reactor (MBBR), even though the electron donor, CH4, was available well in excess of its demand. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31875569-7 2020 Analysis based on Density Functional Theory (DFT) suggests that bacteria able to utilize both acceptors, preferred NO3- over ClO4- due to nitrate reduction having lower energy barriers for proton and electron transfers. Nitrates 138-145 NBL1, DAN family BMP antagonist Homo sapiens 115-118 31972916-9 2020 Ratios of [NO3-]/[SO42-] and [NH4+]/[SO42-] in the four stages declared that nitrate formation preferred heterogeneous conversions. Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 11-14 32090224-2 2020 Pulse radiolysis measurements are performed to find the rate constant of the reaction between NO3 radicals and U(iv) in highly concentrated nitrate solution. Nitrates 141-148 NBL1, DAN family BMP antagonist Homo sapiens 94-97 32211003-3 2020 Nitrate (NO3 -) is often the primary nitrogen source, but it also serves as a signaling molecule to the plant. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 32100606-5 2020 Nitrate signaling has recently been shown to use AON components such as CLE-RS2 and HAR1 to control nodule number. Nitrates 0-7 CM0216.560.nc Lotus japonicus 84-88 32179400-1 2020 Mixotrophic nitrate removal in wastewater from coal pyrolysis was achieved in microbial electrolysis cell with iron anode (iron-MEC). Nitrates 12-19 C-C motif chemokine ligand 28 Homo sapiens 128-131 32100606-9 2020 Hence, while the nitrate-induced control mechanism of nodule number uses AON components, an unknown pathway specific to nitrate may exist downstream of HAR1, acting in parallel with the HAR1> TML pathway. Nitrates 17-24 CM0216.560.nc Lotus japonicus 186-190 32100606-9 2020 Hence, while the nitrate-induced control mechanism of nodule number uses AON components, an unknown pathway specific to nitrate may exist downstream of HAR1, acting in parallel with the HAR1> TML pathway. Nitrates 120-127 CM0216.560.nc Lotus japonicus 152-156 31884326-9 2020 From these results, it can be concluded that NRT1.1 modulates Zn accumulation in plants via a nitrate-dependent pathway. Nitrates 94-101 nitrate transporter 1.1 Arabidopsis thaliana 45-51 31654807-5 2020 Excessive residues (>360 kg/hm2) resulted in obvious phenomenon of preferential flow, which increased the wetting distance, wetted volume, and water content in the lower part of the wetted volume and the concentration of nitrate at the boundary of the wetted volume. Nitrates 221-228 cholinergic receptor muscarinic 2 Homo sapiens 28-31 32129362-8 2020 Nitrate administration in the DN group also decreased miR-34b (p < 0.001) and p53 mRNA (p < 0.001) expression, and increased serum insulin and NOx levels compared to the untreated diabetic rats. Nitrates 0-7 microRNA 34b Rattus norvegicus 54-61 32129362-8 2020 Nitrate administration in the DN group also decreased miR-34b (p < 0.001) and p53 mRNA (p < 0.001) expression, and increased serum insulin and NOx levels compared to the untreated diabetic rats. Nitrates 0-7 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 78-81 32129362-9 2020 CONCLUSIONS: Chronic nitrate supplementation in streptozotocin-induced diabetic rats improved fertility parameters, which may be associated with increased miR-34b and decreased p53 mRNA. Nitrates 21-28 microRNA 34b Rattus norvegicus 155-162 32129362-9 2020 CONCLUSIONS: Chronic nitrate supplementation in streptozotocin-induced diabetic rats improved fertility parameters, which may be associated with increased miR-34b and decreased p53 mRNA. Nitrates 21-28 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 177-180 31868639-5 2020 This is due to the presence of organic and inorganic matter (bicarbonates, nitrates, and chlorides) in surface and tap water, that react with the radicals generated, which reduces the availability of radical species, generating competitive kinetics. Nitrates 75-83 nuclear RNA export factor 1 Homo sapiens 115-118 32440316-9 2020 In the nitrate tolerance group, the level of activated eNOS decreased and the level of deactivated eNOS increased. Nitrates 7-14 nitric oxide synthase 3 Homo sapiens 55-59 32440316-9 2020 In the nitrate tolerance group, the level of activated eNOS decreased and the level of deactivated eNOS increased. Nitrates 7-14 nitric oxide synthase 3 Homo sapiens 99-103 31972252-4 2020 These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate. Nitrates 28-35 xanthine dehydrogenase Mus musculus 144-167 31915951-5 2020 Quantitative reverse transcription polymerase chain reaction analysis revealed a high level of expression of the high affinity nitrate transporter gene, NRT2.1 in A. thaliana treated with Bs L1. Nitrates 127-134 nitrate transporter 2:1 Arabidopsis thaliana 153-157 31972252-4 2020 These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate. Nitrates 243-250 xanthine dehydrogenase Mus musculus 144-167 31810032-1 2020 Nitrate (NO3-) fate estimates in turbulent karst pathways are lacking due, in part, to the difficulty of accessing remote subsurface environments. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31937682-3 2020 Here, based on recently released whole-genome information for bread wheat, the high-affinity nitrate transporter 2 (NRT2) and the nitrate-assimilation-related (NAR) gene family are characterized. Nitrates 93-100 high-affinity nitrate transporter 2.1 Triticum aestivum 116-120 31937682-4 2020 We show that ABA-GE deconjugation is stimulated in bread wheat roots by nitrate resupply following nitrate withdrawal, leading to enhanced root-tissue ABA accumulation, and that this enhancement, in turn, affects the expression of root-type NRT2/NAR genes. Nitrates 72-79 high-affinity nitrate transporter 2.1 Triticum aestivum 241-245 31937682-4 2020 We show that ABA-GE deconjugation is stimulated in bread wheat roots by nitrate resupply following nitrate withdrawal, leading to enhanced root-tissue ABA accumulation, and that this enhancement, in turn, affects the expression of root-type NRT2/NAR genes. Nitrates 99-106 high-affinity nitrate transporter 2.1 Triticum aestivum 241-245 32106816-7 2020 High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R. Nitrates 10-17 angiotensinogen Rattus norvegicus 102-116 31937682-6 2020 Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops. Nitrates 97-104 high-affinity nitrate transporter 2.1 Triticum aestivum 228-232 31937682-6 2020 Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops. Nitrates 181-188 high-affinity nitrate transporter 2.1 Triticum aestivum 228-232 31937682-6 2020 Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops. Nitrates 181-188 high-affinity nitrate transporter 2.1 Triticum aestivum 228-232 31937682-6 2020 Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops. Nitrates 181-188 high-affinity nitrate transporter 2.1 Triticum aestivum 228-232 32106816-7 2020 High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R. Nitrates 10-17 adenosine A2a receptor Rattus norvegicus 193-201 32106816-7 2020 High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R. Nitrates 10-17 angiotensin II receptor, type 2 Rattus norvegicus 207-211 32106816-7 2020 High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R. Nitrates 10-17 angiotensin II receptor, type 1a Rattus norvegicus 165-169 32106816-7 2020 High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R. Nitrates 10-17 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 181-186 32009064-0 2020 East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina. Nitrates 80-87 aldehyde dehydrogenase 2 family member Homo sapiens 34-58 31914408-5 2020 Here, using genetic code expansion to site-specifically nitrate calmodulin at its two tyrosine residues, we assessed the effects of these alterations on calcium binding by calmodulin and on binding and activation of eNOS. Nitrates 56-63 calmodulin 1 Homo sapiens 64-74 31699333-0 2020 Feedforward Control of Plant Nitrate Transporter NRT1.1 Biphasic Adaptive Activity. Nitrates 29-36 immunoglobulin superfamily member 9 Homo sapiens 49-53 31699333-2 2020 Recent discovery of a plasma membrane nitrate transceptor protein NRT1.1-a transporter cum sensor-provides a clue on this toggling mechanism. Nitrates 38-45 immunoglobulin superfamily member 9 Homo sapiens 66-70 31699333-4 2020 Here, we illustrate adaptive responses and regulation of NRT1.1-mediated nitrate signaling in a wide range of extracellular nitrate concentrations. Nitrates 73-80 immunoglobulin superfamily member 9 Homo sapiens 57-61 31699333-4 2020 Here, we illustrate adaptive responses and regulation of NRT1.1-mediated nitrate signaling in a wide range of extracellular nitrate concentrations. Nitrates 124-131 immunoglobulin superfamily member 9 Homo sapiens 57-61 31699333-5 2020 The results show that the homodimeric structure of NRT1.1 and its dimeric switch play an important role in eliciting specific cytosolic calcium waves sensed by the calcineurin-B-like calcium sensor CBL9, which activates the kinase CIPK23, in low nitrate concentration that is, however, impeded in high nitrate concentration. Nitrates 246-253 immunoglobulin superfamily member 9 Homo sapiens 51-55 31699333-5 2020 The results show that the homodimeric structure of NRT1.1 and its dimeric switch play an important role in eliciting specific cytosolic calcium waves sensed by the calcineurin-B-like calcium sensor CBL9, which activates the kinase CIPK23, in low nitrate concentration that is, however, impeded in high nitrate concentration. Nitrates 302-309 immunoglobulin superfamily member 9 Homo sapiens 51-55 31699333-6 2020 Nitrate binding at the high-affinity unit initiates NRT1.1 dimer decoupling and priming of the Thr101 site for phosphorylation by CIPK23. Nitrates 0-7 immunoglobulin superfamily member 9 Homo sapiens 52-56 31699333-7 2020 This phosphorylation stabilizes the NRT1.1 monomeric state, acting as a high-affinity nitrate transceptor. Nitrates 86-93 immunoglobulin superfamily member 9 Homo sapiens 36-40 31699333-8 2020 However, nitrate binding in both monomers, retaining the unmodified NRT1.1 state through dimerization, attenuates CIPK23 activity and thereby maintains the low-affinity mode of nitrate signaling and transport. Nitrates 9-16 immunoglobulin superfamily member 9 Homo sapiens 68-72 31699333-9 2020 This phosphorylation-led modulation of NRT1.1 activity shows bistable behavior controlled by an incoherent feedforward loop, which integrates nitrate-induced positive and negative regulatory effects on CIPK23. Nitrates 142-149 immunoglobulin superfamily member 9 Homo sapiens 39-43 31837546-1 2020 This study determined the spatial and temporal changes in natural abundance of stable isotopes (delta13C, delta15N, and delta18O) with regard to nitrate (NO3-) and retained sludge in a nitrifying bioreactor. Nitrates 145-152 NBL1, DAN family BMP antagonist Homo sapiens 154-157 32117389-8 2020 An RNA sequencing analysis revealed that ZmCHB101 regulates the expression of genes involved in nitrate transport, including ZmNRT2.1 and ZmNRT2.2. Nitrates 96-103 nitrate transport 2 Zea mays 125-133 31896222-5 2020 It was found that the nitrogen isotopic values of nitrate in PM2.5 (hereafter as delta15N-NO3-) ranged widely from -3.1% to + 11.4%, with a mean value of 3.5 +- 3.7%. Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 90-93 31967806-0 2020 Investigation into the Concentrations and Sources of Nitrates and Nitrites in Milk and Plant-based Powders. Nitrates 53-61 Weaning weight-maternal milk Bos taurus 78-82 32117389-8 2020 An RNA sequencing analysis revealed that ZmCHB101 regulates the expression of genes involved in nitrate transport, including ZmNRT2.1 and ZmNRT2.2. Nitrates 96-103 putative high affinity nitrate transporter Zea mays 138-146 31967806-1 2020 Milk powders in the United States (US) may contain nitrates and nitrites from several potential sources. Nitrates 51-59 Weaning weight-maternal milk Bos taurus 0-4 31967806-4 2020 To date, the concentrations of nitrates and nitrites in milk and plant-based powders in the US is unknown. Nitrates 31-39 Weaning weight-maternal milk Bos taurus 56-60 32117389-9 2020 The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate. Nitrates 72-79 nitrate transport 2 Zea mays 138-146 31967806-10 2020 Background nitrate concentrations in US produced milk powder samples averaged 17 +- 12 mg/kg. Nitrates 11-18 Weaning weight-maternal milk Bos taurus 49-53 32117389-9 2020 The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate. Nitrates 72-79 putative high affinity nitrate transporter Zea mays 151-159 32117389-9 2020 The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate. Nitrates 223-230 nitrate transport 2 Zea mays 138-146 32117389-9 2020 The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate. Nitrates 223-230 putative high affinity nitrate transporter Zea mays 151-159 31429204-10 2020 MCT-associated up-regulation of nNOS in the lung appeared to be dose-dependently prevented by nitrate treatment. Nitrates 94-101 nitric oxide synthase 1 Rattus norvegicus 32-36 31429204-13 2020 The suppression of MnSOD and nNOS expression by nitrate could be interpreted as reduced demand of endogenous antioxidant defence in this model. Nitrates 48-55 superoxide dismutase 2 Rattus norvegicus 19-24 31429204-13 2020 The suppression of MnSOD and nNOS expression by nitrate could be interpreted as reduced demand of endogenous antioxidant defence in this model. Nitrates 48-55 nitric oxide synthase 1 Rattus norvegicus 29-33 31581317-2 2020 A wheat nitrate-inducible NAC transcription factor, TaNAC2 plays a critical role in promoting crop growth and nitrogen use efficiency and now we show its role in seed vigour. Nitrates 8-15 NAC domain-containing protein 2 Triticum aestivum 52-58 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 212-219 high-affinity nitrate transporter 2.1 Triticum aestivum 118-124 31581317-3 2020 We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour. Nitrates 58-65 NAC domain-containing protein 2 Triticum aestivum 16-22 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 212-219 NAC domain-containing protein 2 Triticum aestivum 156-162 31581317-3 2020 We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour. Nitrates 58-65 high-affinity nitrate transporter 2.1 Triticum aestivum 48-52 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 212-219 high-affinity nitrate transporter 2.1 Triticum aestivum 20-24 31581317-3 2020 We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour. Nitrates 58-65 high-affinity nitrate transporter 2.1 Triticum aestivum 78-84 31581317-4 2020 Overexpressing TaNAC2-5A increases grain nitrate concentration and seed vigour by directly binding to the promoter of TaNRT2.5-3B and positively regulating its expression. Nitrates 41-48 NAC domain-containing protein 2 Triticum aestivum 15-21 31581317-6 2020 In Xenopus oocyte assays TaNRT2.5 requires a partner protein TaNAR2.1 to give nitrate transport activity, and the transporter locates to the tonoplast in a tobacco leaf transient expression system. Nitrates 78-85 high-affinity nitrate transporter 2.1 Triticum aestivum 25-31 31581317-6 2020 In Xenopus oocyte assays TaNRT2.5 requires a partner protein TaNAR2.1 to give nitrate transport activity, and the transporter locates to the tonoplast in a tobacco leaf transient expression system. Nitrates 78-85 probable high-affinity nitrate transporter-activating protein 2.2 Triticum aestivum 61-69 31581317-7 2020 Furthermore, in the root TaNRT2.5 and TaNRT2.1 function in post-anthesis acquisition of soil nitrate. Nitrates 93-100 high-affinity nitrate transporter 2.1 Triticum aestivum 25-31 31581317-7 2020 Furthermore, in the root TaNRT2.5 and TaNRT2.1 function in post-anthesis acquisition of soil nitrate. Nitrates 93-100 high-affinity nitrate transporter 2.1 Triticum aestivum 38-44 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 59-66 high-affinity nitrate transporter 2.1 Triticum aestivum 18-24 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 59-66 high-affinity nitrate transporter 2.1 Triticum aestivum 20-24 31581317-8 2020 Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour. Nitrates 212-219 high-affinity nitrate transporter 2.1 Triticum aestivum 18-24 31730198-4 2020 Histological analysis of the root tip revealed decreased cell division and elongation in the cytokinin receptor double mutant ahk2/ahk4 as compared with wild-type plants under a sufficient nitrate regime. Nitrates 189-196 histidine kinase 2 Arabidopsis thaliana 126-130 31928660-1 2020 Physiological effects of ammonium (NH4+) and nitrate (NO3-) on tea have confirmed that tea plants prefer NH4+ as the dominant nitrogen (N) source. Nitrates 45-52 NBL1, DAN family BMP antagonist Homo sapiens 54-57 31730198-4 2020 Histological analysis of the root tip revealed decreased cell division and elongation in the cytokinin receptor double mutant ahk2/ahk4 as compared with wild-type plants under a sufficient nitrate regime. Nitrates 189-196 CHASE domain containing histidine kinase protein Arabidopsis thaliana 131-135 31956150-3 2020 In mild HF patients, log (ANP + BNP) in the AO was an independent predictor of (CS-AO) cGMP among hemodynamics and nitrate therapy. Nitrates 115-122 natriuretic peptide B Homo sapiens 32-35 31816715-4 2020 No water films are observed in the proposed TRGO-based potassium (K+-TRGO-ISEs) and nitrate (NO3--TRGO-ISEs) selective SC-ISEs. Nitrates 84-91 NBL1, DAN family BMP antagonist Homo sapiens 93-96 31445413-9 2020 Significant enhancement of nitrate in Pb-O-Cl-N-S particles was observed when the RH was greater than 60%, emphasizing the importance of heterogeneous hydrolysis of N2O5 on the formation of Pb(NO3)2. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 193-196 32038262-0 2019 Dietary Nitrate Protects Against Skin Flap Ischemia-Reperfusion Injury in Rats via Modulation of Antioxidative Action and Reduction of Inflammatory Responses. Nitrates 8-15 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 38-42 32038262-3 2019 Here, we evaluated the therapeutic effects of dietary nitrate on skin flap recovery following ischemia reperfusion (IR). Nitrates 54-61 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 70-74 32038262-5 2019 It was found that oral administration of nitrate increased serum nitrate and nitrite levels, protected cells from apoptosis, and attenuated flap tissue edema. Nitrates 41-48 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 140-144 32038262-7 2019 Moreover, the macrophage and neutrophil infiltration in the flap was significantly attenuated by nitrate supplementation, as were the pro-inflammatory cytokines. Nitrates 97-104 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 60-64 32038262-8 2019 In sum, we found that oral administration of nitrate can attenuate skin flap IR injury through the regulation of oxidative stress and inflammatory response. Nitrates 45-52 arachidonate 5-lipoxygenase activating protein Rattus norvegicus 72-76 32038669-6 2019 To validate the physiological response of plants to DHS exposure, real-time RT-PCR analyses were performed on those genes most involved in nitrate acquisition, such as ZmNRT2.1, ZmNRT2.2, ZmMHA2 (coding for two high-affinity nitrate transporters and a PM H+-proton pump), ZmNADH:NR, ZmNADPH:NR, and ZmNiR (coding for nitrate reductases and nitrite reductase). Nitrates 139-146 nitrate transport 2 Zea mays 168-176 31797274-11 2020 Notable relations between Ca2+ and NO3-, particularly in PM10 at Goa, indicated their release from mining related activities. Nitrates 35-39 tripartite motif containing 47 Homo sapiens 65-68 32001953-4 2020 Moreover, nitrate significantly decreased triglyceride content and mRNA expression levels of Ppargamma in liver and Glut4 in skeletal muscle. Nitrates 10-17 peroxisome proliferator activated receptor gamma Mus musculus 93-102 32001953-4 2020 Moreover, nitrate significantly decreased triglyceride content and mRNA expression levels of Ppargamma in liver and Glut4 in skeletal muscle. Nitrates 10-17 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 116-121 31595477-1 2020 Nitrification is the microbial-mediated transformation of ammonium (NH4 +) into nitrate (NO3 -). Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 89-92 31791519-5 2020 Compared with the dry season, the fact that water quality worsened in the wet season and that there were positive correlations for nitrate (NO3-) between water and the corresponding soil samples suggested that the riparian-soil environment affected the adjacent water quality mainly in the wet season. Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 31595466-2 2020 Plants assimilate inorganic form of N [nitrate (NO3 -), nitrite (NO2 -) or ammonium (NH4 +)] and incorporate into amino acids. Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 48-51 31765889-6 2020 Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. Nitrates 17-24 arginase, liver Mus musculus 140-150 31595466-6 2020 In cytosol the NO3 - is reduced to NO2 - by cytosolic nitrate reductase (NR) and the produced NO2 - is further reduced to NH4 + by nitrite reductase (NiR) in plastids. Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 15-18 31604144-7 2020 Sialin, a known nitrate transporter, was detected in myoblasts; nitrate uptake decreased after sialin knockdown. Nitrates 16-23 solute carrier family 17 member 5 Homo sapiens 0-6 31604144-8 2020 Inhibition of chloride channel 1 (CLC1) also led to significantly decreased uptake of nitrate. Nitrates 86-93 chloride voltage-gated channel 1 Homo sapiens 14-32 31604144-8 2020 Inhibition of chloride channel 1 (CLC1) also led to significantly decreased uptake of nitrate. Nitrates 86-93 chloride voltage-gated channel 1 Homo sapiens 34-38 31765889-6 2020 Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. Nitrates 17-24 early growth response 2 Mus musculus 152-157 31765889-6 2020 Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. Nitrates 17-24 interleukin 10 Mus musculus 159-164 31883320-8 2019 In this context, the fact that animals jointly receiving GTN and DSF developed tolerance to GTN, and in animals that in addition to GTN and DSF also received LA such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2. Nitrates 257-264 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 343-347 31641075-0 2020 SDG8-mediated histone methylation and RNA processing function in the response to nitrate signaling. Nitrates 81-88 histone-lysine N-methyltransferase Arabidopsis thaliana 0-4 31641075-2 2020 Here, we show that the Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP 8 (SDG8) mediates genome-wide changes in H3K36 methylation at specific genomic loci functionally relevant to nitrate treatments. Nitrates 210-217 histone-lysine N-methyltransferase Arabidopsis thaliana 84-102 31641075-2 2020 Here, we show that the Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP 8 (SDG8) mediates genome-wide changes in H3K36 methylation at specific genomic loci functionally relevant to nitrate treatments. Nitrates 210-217 histone-lysine N-methyltransferase Arabidopsis thaliana 104-108 31606555-8 2020 In both reactors, nitrate (NO3-) formed as the main byproduct at the anode, but in the undivided reactor it was reduced at the stainless steel cathode to ammonia. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 31883320-8 2019 In this context, the fact that animals jointly receiving GTN and DSF developed tolerance to GTN, and in animals that in addition to GTN and DSF also received LA such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2. Nitrates 257-264 aldehyde dehydrogenase 2 family member Rattus norvegicus 395-400 31909112-10 2020 Since NO is oxidized to NO2 - and nitrate (NO3 -), it is common practice to quantitate total NO2 -/NO3 - as a measure of the NO level. Nitrates 34-41 NBL1, DAN family BMP antagonist Homo sapiens 43-46 31767742-7 2019 Specifically, we find that the ocean can exhibit fundamental transitions in the species of nitrogen dominating the fixed-N inventory--from nitrate (NO3 -) to ammonium (NH4 +)--and that as this transition occurs, the inventory can partially collapse relative to P due to progressive spatial decoupling between the loci of NH4 + oxidation, NO3 - reduction, and nitrogen fixation. Nitrates 139-146 NBL1, DAN family BMP antagonist Homo sapiens 148-151 31766976-11 2019 Conclusions A higher relative abundance of oral nitrate-reducing bacteria was associated with lower insulin resistance and plasma glucose in the full cohort and with mean systolic BP in participants with normotension. Nitrates 48-55 insulin Homo sapiens 100-107 31867024-5 2019 Nitrate uptake and assimilation is enhanced in omeprazole treated plants through changes in nitrate reductase activity, primary metabolism, and gene expression. Nitrates 0-7 nitrate reductase [NADH] 1 Zea mays 92-109 31867024-6 2019 Omeprazole enhances nitrate assimilation through an interaction with nitrate reductase, altering its activation state and affinity for nitrate as a substrate. Nitrates 20-27 nitrate reductase [NADH] 1 Zea mays 69-86 31656997-3 2019 Probability of perched and shallow groundwater nitrate concentration > 3 mg L-1 exhibited strong spatial autocorrelation, with effective ranges of 1091 m and 3743 m from semivariogram, respectively. Nitrates 47-54 immunoglobulin kappa variable 1-16 Homo sapiens 76-79 31557655-3 2019 NO3--N produced in Anammox could be further reduced through (partial) denitrification and dissimilatory nitrate reduction to ammonium (DNRA). Nitrates 104-111 NBL1, DAN family BMP antagonist Homo sapiens 0-3 31600544-2 2019 Research has revealed an alternative NO-generating pathway, independent of NO synthase (NOS), in which the inorganic anions nitrate (NO3-) and nitrite (NO2-) are serially reduced to form NO. Nitrates 124-131 nitric oxide synthase 1, neuronal Mus musculus 75-86 31539849-1 2019 The conversion of natural saltmarshes to shrimp aquaculture ponds can potentially influence the biogeochemical cycling of nutrients in coastal wetlands, but its impact on the dynamics of sediment dissimilatory nitrate (NO3-) reduction remains poorly understood. Nitrates 210-217 NBL1, DAN family BMP antagonist Homo sapiens 219-222 31350908-7 2019 This muscle nitrate reservoir has been found to be an important source of nitrite and nitric oxide (NO) via its reduction by tissue xanthine oxidoreductase. Nitrates 12-19 xanthine dehydrogenase Homo sapiens 132-155 31350908-10 2019 Consistent with these observations, and with previous suggestions of active muscle nitrate transport, we present western blot data to show significant expression of the active nitrate/nitrite transporter sialin in human skeletal muscle. Nitrates 83-90 solute carrier family 17 member 5 Homo sapiens 204-210 31350908-10 2019 Consistent with these observations, and with previous suggestions of active muscle nitrate transport, we present western blot data to show significant expression of the active nitrate/nitrite transporter sialin in human skeletal muscle. Nitrates 176-183 solute carrier family 17 member 5 Homo sapiens 204-210 31414122-4 2019 Exposure to Pb specifically stimulated NRT1.1-mediated nitrate uptake. Nitrates 55-62 nitrate transporter 1.1 Arabidopsis thaliana 39-45 31634463-0 2019 Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy. Nitrates 94-101 phosphodiesterase 5A, cGMP-specific Mus musculus 16-20 31634463-8 2019 Nitrate treatment normalized plasma nitrite levels, relaxation of urethra to sodium nitroprusside, PDE5 phosphorylation in the urethra and bladder, and urine volume in Sickle mice. Nitrates 0-7 phosphodiesterase 5A, cGMP-specific Mus musculus 99-103 31634463-10 2019 Inorganic nitrate supplementation normalized voiding in Sickle mice through mechanisms likely involving upregulation of PDE5 activity. Nitrates 10-17 phosphodiesterase 5A, cGMP-specific Mus musculus 120-124 31450447-1 2019 Simultaneous determination of nitrate (NO3 ) and nitrite (NO2 ) in vegetables was performed on a poly(1-vinylimidazole-co-ethylene dimethacrylate) (VIM-EDMA) monolithic column by capillary liquid chromatography (LC) with UV detection. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 39-42 31414122-5 2019 Loss of function of NRT1.1 in nrt1.1-knockout mutants resulted in greater Pb toxicity and higher Pb accumulation in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and null-mutants for NRT1.2, NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 116-123 nitrate transporter 1.1 Arabidopsis thaliana 20-26 31727786-3 2019 Here, we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean (Glycine max) within two highly conserved nitrate-induced (NOI) domains. Nitrates 145-152 RPM1 interacting protein 4 Arabidopsis thaliana 55-59 31414122-5 2019 Loss of function of NRT1.1 in nrt1.1-knockout mutants resulted in greater Pb toxicity and higher Pb accumulation in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and null-mutants for NRT1.2, NRT2.1, NRT2.2, NRT2.4, and NRT2.5. Nitrates 116-123 nitrate transporter 1.1 Arabidopsis thaliana 30-34 31616875-0 2019 The riddle of the forbidden UV absorption of aqueous nitrate: the oscillator strength of the n pi* transition in NO3- including second order vibronic coupling. Nitrates 53-60 NBL1, DAN family BMP antagonist Homo sapiens 115-118 31697768-3 2019 Nitrification is a process which consumes oxygen and ammonium (NH4+), and supplies nitrate (NO3-). Nitrates 83-90 NBL1, DAN family BMP antagonist Homo sapiens 92-95 31465952-7 2019 The mechanism explorations revealed that micro-aerobic condition not only particularly enriched the sulfide-oxidizing, nitrate-reducing bacteria (soNRB) but also promoted the microbial zonation of sulfate-reducing bacteria (SRB) and soNRB, thereby achieving more S0 transformation in the effluent. Nitrates 119-126 chaperonin containing TCP1 subunit 4 Homo sapiens 197-238 31418937-0 2019 The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep. Nitrates 23-30 LOC105613195 Ovis aries 53-60 31541562-6 2019 ABSTRACT: Dietary nitrate (NO3 - ) supplementation, which increases plasma nitrite (NO2 - ) concentration, has been reported to attenuate skeletal muscle fatigue development. Nitrates 18-25 NBL1, DAN family BMP antagonist Mus musculus 27-30 31279186-8 2019 In conclusion, the combined use of Ca(NO3)2 addition and AER capping is a more promising strategy for the control of sedimentary phosphorus release than the single use of Ca(NO3)2 addition from the point of view of both the control efficiency of P release from sediments and the releasing risk of the added nitrate. Nitrates 307-314 NBL1, DAN family BMP antagonist Homo sapiens 38-41 31661786-1 2019 Soil nitrate-nitrogen (NO3--N) is one of the primary factors used to control nitrogen topdressing application during the crop growth period. Nitrates 5-21 NBL1, DAN family BMP antagonist Homo sapiens 23-26 31203953-5 2019 This fully automated analyzer had a limit of detection of 0.02 mumol L-1 for nitrite and 0.14 mumol L-1 for nitrate. Nitrates 108-115 L1 cell adhesion molecule Homo sapiens 100-103 31203953-7 2019 With automated dilution, the calibration curve for nitrate was linear up to a concentration of 400 mumol L-1 (R2 > 0.999). Nitrates 51-58 L1 cell adhesion molecule Homo sapiens 105-108 31623611-14 2019 This implies that drinking water nitrate levels should be taken into account when evaluating the effect of meat consumption on endogenous formation of NOC. Nitrates 33-40 nocturnin Homo sapiens 151-154 31185400-7 2019 We noted: i) The areal nitrate reduction rates for the marsh, fringe, and estuary zones were 29.29 +- 3.28, 18.83 +- 1.31, and 10.83 +- 0.62 mg N m-2 day-1, respectively; ii) the majority (~93%) of NO3 was converted to N2O, indicating denitrification was the major NO3 reduction pathway; iii) the submerged, eroded marsh soils (peat fringe zone) will play a large role in nitrate reduction due to increased contact time with the surface water. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 198-201 31626627-0 2019 Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana. Nitrates 0-7 OBF binding protein 4 Arabidopsis thaliana 19-23 31626627-0 2019 Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana. Nitrates 0-7 xyloglucan endotransglucosylase/hydrolase 9 Arabidopsis thaliana 24-28 31626627-12 2019 Based on these findings we propose a novel mechanism by which OBP4 antagonistically controls XTH9 expression and the OBP4-XTH9 module elaborately sustains LR development in response to nitrate treatment. Nitrates 185-192 OBF binding protein 4 Arabidopsis thaliana 117-126 31618861-3 2019 The Kendall test shows significant declines in fecal coliform bacteria (FCB) and ammonia (NH3) in the upper reaches and increases in nitrate (NO3) and NH3 in the lower reaches. Nitrates 133-140 NBL1, DAN family BMP antagonist Homo sapiens 142-145 31323502-1 2019 This study investigated the feasibility of a new biological nitrogen removal process that integrates sulfur-driven autotrophic denitratation (NO3- NO2-) and anaerobic ammonium oxidation (Anammox) for simultaneous removal of nitrate and ammonium from industrial wastewater. Nitrates 224-231 NBL1, DAN family BMP antagonist Homo sapiens 142-145 31560362-0 2019 Rb3SbF3(NO3)3: an excellent antimony nitrate nonlinear optical material with a strong second harmonic generation response fabricated by a rational multi-component design. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 8-11 31560362-1 2019 A novel antimony fluoride nitrate, Rb3SbF3(NO3)3, fabricated by a rational multi-component design, has been successfully synthesized by a rapid evaporation concentration method. Nitrates 8-33 NBL1, DAN family BMP antagonist Homo sapiens 43-46 31185400-7 2019 We noted: i) The areal nitrate reduction rates for the marsh, fringe, and estuary zones were 29.29 +- 3.28, 18.83 +- 1.31, and 10.83 +- 0.62 mg N m-2 day-1, respectively; ii) the majority (~93%) of NO3 was converted to N2O, indicating denitrification was the major NO3 reduction pathway; iii) the submerged, eroded marsh soils (peat fringe zone) will play a large role in nitrate reduction due to increased contact time with the surface water. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 265-268 31195279-1 2019 In the framework of the Life+ InSiTrate project, a pilot-plant was established to demonstrate the viability of inducing in-situ heterotrophic denitrification to remediate nitrate (NO3-)-polluted groundwater. Nitrates 171-178 NBL1, DAN family BMP antagonist Homo sapiens 180-183 31581560-6 2019 The results show that the methanogenesis gene, Mcr, was undetected but more carbon fixation genes than nitrate reduction and sulfate genes were found. Nitrates 103-110 nuclear receptor subfamily 3 group C member 2 Homo sapiens 47-50 31336256-2 2019 However, the major issues of nitrate (NO3--N) residue and instability in the current combination of nitritation and anammox process necessitates being addressed efficiently. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 38-41 31264223-5 2019 Biochemical and molecular analyses revealed that NLP7, a master nitrate regulatory transcription factor, directly bound to the nitrate-responsive cis-element (NRE)-like motif of the T5120 promoter and activated T5120 transcription. Nitrates 64-71 NIN like protein 7 Arabidopsis thaliana 49-53 31431511-0 2019 Phosphorylation-mediated dynamics of nitrate transceptor NRT1.1 regulate auxin flux and nitrate signaling in lateral root growth. Nitrates 37-44 nitrate transporter 1.1 Arabidopsis thaliana 57-63 31264223-6 2019 In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation. Nitrates 42-49 NIN like protein 7 Arabidopsis thaliana 92-96 31264223-6 2019 In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation. Nitrates 42-49 NIN like protein 7 Arabidopsis thaliana 142-146 31264223-6 2019 In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation. Nitrates 156-163 NIN like protein 7 Arabidopsis thaliana 92-96 31264223-6 2019 In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation. Nitrates 156-163 NIN like protein 7 Arabidopsis thaliana 142-146 31264223-7 2019 Interestingly, the expression of T5120 was regulated by the nitrate sensor NRT1.1. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 75-79 31264223-8 2019 Therefore, T5120 is modulated by NLP7 and NRT1.1 to regulate nitrate signalling. Nitrates 61-68 NIN like protein 7 Arabidopsis thaliana 33-37 31264223-8 2019 Therefore, T5120 is modulated by NLP7 and NRT1.1 to regulate nitrate signalling. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 42-46 31295558-17 2019 A non-significant positive correlation was observed between the change in salivary sialin and salivary NO3- concentrations (r = 0.18, P = 0.06). Nitrates 103-107 solute carrier family 17 member 5 Homo sapiens 83-89 31431511-0 2019 Phosphorylation-mediated dynamics of nitrate transceptor NRT1.1 regulate auxin flux and nitrate signaling in lateral root growth. Nitrates 88-95 nitrate transporter 1.1 Arabidopsis thaliana 57-63 31431511-2 2019 NRT1.1 regulates lateral root (LR) development by modulating nitrate-dependent basipetal auxin export and nitrate-mediated signal transduction. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 0-4 31431511-2 2019 NRT1.1 regulates lateral root (LR) development by modulating nitrate-dependent basipetal auxin export and nitrate-mediated signal transduction. Nitrates 106-113 nitrate transporter 1.1 Arabidopsis thaliana 0-4 31431511-5 2019 The phosphomimetic NRT1.1T101D form showed fast lateral mobility and membrane partitioning that facilitated auxin flux under low-nitrate conditions. Nitrates 129-136 nitrate transporter 1.1 Arabidopsis thaliana 19-23 31465193-2 2019 Herein, an innovative bifunctional nanocomposite HFO@TPR was developed for synchronous nitrate/phosphate elimination from water. Nitrates 87-94 translocated promoter region, nuclear basket protein Homo sapiens 53-56 31465193-3 2019 A macroporous polystyrene microspheres modified with triethylamine functional groups was synthesized as the host of HFO@TPR for selective nitrate removal, and Fe(III) hydroxide (HFO) nanoparticles were implanted inside as the active species for specific phosphate removal. Nitrates 138-145 translocated promoter region, nuclear basket protein Homo sapiens 120-123 31465193-4 2019 Compared to other commercial adsorbents, HFO@TPR exhibited outstanding selectivity and preference toward nitrates and phosphates, and the coexisting anions exert an insignificant effect on adsorption performance. Nitrates 105-113 translocated promoter region, nuclear basket protein Homo sapiens 45-48 31465193-5 2019 Such exceptional bifuntionality of HFO@TPR was achieved through two pathways, that is, nitrate was preferentially adsorbed by the fixed triethylamine groups through the electrostatic attraction, and phosphate was preferentially captured by the encapsulated HFO nanoparticles through the inner-sphere complexation. Nitrates 87-94 translocated promoter region, nuclear basket protein Homo sapiens 39-42 31465193-7 2019 In addition, column adsorption experiments demonstrated that HFO@TPR could eliminate nitrate from 18 to <10 mg N/L with the treatment capacity of ~600 bed volume (BV), and meanwhile remove phosphate from 2.5 to <0.2 mg P/L with the treatment capacity of ~750 BV. Nitrates 85-92 translocated promoter region, nuclear basket protein Homo sapiens 65-68 31431511-6 2019 By contrast, non-phosphorylatable NRT1.1T101A showed low lateral mobility and oligomerized at the plasma membrane (PM), where it induced endocytosis via the clathrin-mediated endocytosis and microdomain-mediated endocytosis pathways under high-nitrate conditions. Nitrates 244-251 nitrate transporter 1.1 Arabidopsis thaliana 34-38 31548257-3 2019 Here we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean within two highly conserved nitrate-induced (NOI) domains. Nitrates 130-137 RPM1 interacting protein 4 Arabidopsis thaliana 54-58 31087098-0 2019 Ammonium and nitrate regulate NH4+ uptake activity of Arabidopsis ammonium transporter AtAMT1;3 via phosphorylation at multiple C-terminal sites. Nitrates 13-20 anthranilate synthase alpha subunit 1 Arabidopsis thaliana 87-93 31087098-3 2019 Here, we showed that the Arabidopsis root epidermis-expressed ammonium transporter AtAMT1;3 was dynamically (de-)phosphorylated at multiple sites in the cytosolic C-terminal region (CTR) responding to ammonium and nitrate signals. Nitrates 214-221 ammonium transporter 1;3 Arabidopsis thaliana 83-91 31129334-5 2019 During the nitrate reduction by Zn-Ag/hv/HCOOH process, rapid reduction of NO3- to NO2- was primarily caused by ZnAg bimetal. Nitrates 11-18 NBL1, DAN family BMP antagonist Homo sapiens 75-78 31325834-10 2019 Nitrate exposure was associated with a significantly increased risk of limb deficiencies (RR for 1 mg/L (RR1) = 1.26, 95% CI = 1.05, 1.51) in models without well restriction. Nitrates 0-7 ribonucleotide reductase catalytic subunit M1 Homo sapiens 90-103 31200219-6 2019 Elevated groundwater nitrate concentrations (>50 mg L-1) create a large stoichiometric demand for bioavailable DOC in discharging groundwater. Nitrates 21-28 immunoglobulin kappa variable 1-16 Homo sapiens 55-58 31513626-3 2019 We discovered a hyper PHB-accumulating denitrifying bacterium, Zobellella denitrificans ZD1 (referred as strain ZD1 hereafter) capable of using non-sterile crude glycerol (a waste from biodiesel production) and nitrate to produce high PHB yield under saline conditions. Nitrates 211-218 ZD1 Homo sapiens 88-91 31513626-3 2019 We discovered a hyper PHB-accumulating denitrifying bacterium, Zobellella denitrificans ZD1 (referred as strain ZD1 hereafter) capable of using non-sterile crude glycerol (a waste from biodiesel production) and nitrate to produce high PHB yield under saline conditions. Nitrates 211-218 ZD1 Homo sapiens 112-115 31513626-5 2019 In this study, we discovered a complete pathway of glycerol conversion to PHB, a novel PHB synthesis gene cluster, a salt-tolerant gene cluster, denitrifying genes, and an assimilatory nitrate reduction gene cluster in the ZD1 genome. Nitrates 185-192 ZD1 Homo sapiens 223-226 31513626-7 2019 Higher levels of PHB accumulation were linked to higher expression levels of the PHB synthesis gene cluster in ZD1 grown with glycerol and nitrate under saline conditions. Nitrates 139-146 ZD1 Homo sapiens 111-114 31141766-4 2019 Further it was found that the sensor is highly selective towards fluoride over other anions including chloride, bromide, iodide, nitrate, borate, perchlorate and can quantitatively detect fluoride at ppb level with a limit of detection of 0.02 mg/ L or 20 ppb. Nitrates 129-136 histatin 1 Homo sapiens 200-203 31348674-1 2019 Over the last decade there has been substantial interest in the health and athletic performance benefits associated with acute and chronic dietary nitrate (NO3-) supplementation. Nitrates 147-154 NBL1, DAN family BMP antagonist Homo sapiens 156-159 31325834-10 2019 Nitrate exposure was associated with a significantly increased risk of limb deficiencies (RR for 1 mg/L (RR1) = 1.26, 95% CI = 1.05, 1.51) in models without well restriction. Nitrates 0-7 ribonucleotide reductase catalytic subunit M1 Homo sapiens 105-108 31325834-11 2019 Nitrate was also weakly associated with an increased risk of congenital heart defects (RR1 = 1.13, 95%CI = 0.93, 1.51) and neural tube defects (RR1 = 1.18, 95%CI = 0.93, 1.51) in models with well restriction (<10%). Nitrates 0-7 ribonucleotide reductase catalytic subunit M1 Homo sapiens 87-90 31325834-11 2019 Nitrate was also weakly associated with an increased risk of congenital heart defects (RR1 = 1.13, 95%CI = 0.93, 1.51) and neural tube defects (RR1 = 1.18, 95%CI = 0.93, 1.51) in models with well restriction (<10%). Nitrates 0-7 ribonucleotide reductase catalytic subunit M1 Homo sapiens 144-147 31173908-3 2019 In the present study, we tested the hypothesis that lack of myoglobin expression would decrease nitrate levels in skeletal muscle. Nitrates 96-103 myoglobin Mus musculus 60-69 31173908-4 2019 We observed a modest but significant decrease of nitrate level in skeletal muscle of myoglobin deficient mice compared to littermate control mice (17.3 vs 12.8 nmol/g). Nitrates 49-56 myoglobin Mus musculus 85-94 31173908-5 2019 In contrast, a NOS inhibitor, L-NAME or a low nitrite/nitrate diet treatment led to more pronounced decreases of nitrate levels in the skeletal muscle of both control and myoglobin deficient mice. Nitrates 54-61 myoglobin Mus musculus 171-180 31437742-6 2019 Dissolved organic N was the dominant component of total N followed by nitrate (NO3-) and ammonium (NH4+). Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 79-82 31173908-5 2019 In contrast, a NOS inhibitor, L-NAME or a low nitrite/nitrate diet treatment led to more pronounced decreases of nitrate levels in the skeletal muscle of both control and myoglobin deficient mice. Nitrates 113-120 myoglobin Mus musculus 171-180 31667449-6 2019 The main source of PON-derived aerosols is monoterpene nitrates that have been chemically processed to lose their nitrate functionality through aqueous chemistry. Nitrates 55-62 paraoxonase 1 Homo sapiens 19-22 31552707-6 2019 Untreated Ins2Akita mice showed significant increases in urinary albumin excretion, histological changes, glomerular macrophage recruitment, the inflammatory cytokine KC-GRO/CXCL1, and urinary thiobarbituric acid reactive substances (TBARS) excretion as an indicator of oxidative stress, along with a significant reduction in kidney nitrate + nitrite levels compared to control mice at 18 weeks of age. Nitrates 333-340 insulin II Mus musculus 10-14 32634879-3 2020 Nitrate in blood is taken up by sialin, a nitrate transporter and concentrated in salivary glands and secreted into saliva. Nitrates 0-7 solute carrier family 17 member 5 Homo sapiens 32-38 31667449-7 2019 In contrast, the major portion of aqueous aerosol and in-cloud PON, which retains its nitrate moiety, are soluble isoprene nitrates. Nitrates 86-93 paraoxonase 1 Homo sapiens 63-66 31128332-6 2019 The SOM results support the in-reservoir findings, revealing 2-MIB and Geosmin to be associated with high ammonium relative to nitrate for all 5 reservoirs. Nitrates 127-134 MIB E3 ubiquitin protein ligase 1 Homo sapiens 63-66 31128393-1 2019 Nitrate (NO3-) and bicarbonate (HCO3-) are harmful for the water quality and can potentially create negative impacts to aquatic organisms, crops and humans. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31456696-4 2019 Most of the ingested NO is in the form of nitrate ( NO 3 - ). Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 54-58 30980427-1 2019 RATIONALE: The nitrogen and oxygen (delta15 N, delta18 O, and delta17 O values) isotopic compositions of nitrate (NO3 - ) are crucial tracers of nutrient nitrogen (N) sources and dynamics in aquatic systems. Nitrates 105-112 NBL1, DAN family BMP antagonist Homo sapiens 114-117 30980427-8 2019 The uncertainties for dissolved nitrate reference materials (USGS32, USGS34, USGS35, IAEA-NO3 ) were +-0.2% for delta15 N values and +-0.3% for delta18 O values using IRMS. Nitrates 32-39 NBL1, DAN family BMP antagonist Homo sapiens 90-93 31390768-4 2019 Batch experiments were conducted on water samples contaminated by 300 mg L-1 of nitrate. Nitrates 80-87 immunoglobulin kappa variable 1-16 Homo sapiens 73-76 31390768-6 2019 The results showed that almost complete nitrate removal (>99.8%) was always achieved after 15 min at a concentration of bimetallic nanoparticles higher than 0.2 g L-1. Nitrates 40-47 immunoglobulin kappa variable 1-16 Homo sapiens 166-169 31211619-11 2019 Serum nitrate levels were increased in antibiotic-treated Pxr+/+and Pxr-/- mice. Nitrates 6-13 nuclear receptor subfamily 1, group I, member 2 Mus musculus 58-61 30949701-5 2019 Key breakthroughs include elucidation of the mechanisms underlying post-translational regulation of NIN-LIKE PROTEIN (NLP) and PHOSPHATE STARVATION RESPONSE (PHR) family transcription factors, which function as master regulators of responses to nitrate and phosphate starvation, respectively. Nitrates 245-252 ninein like Homo sapiens 100-116 31211619-11 2019 Serum nitrate levels were increased in antibiotic-treated Pxr+/+and Pxr-/- mice. Nitrates 6-13 nuclear receptor subfamily 1, group I, member 2 Mus musculus 68-71 31227868-5 2019 All nitrate produced by anammox bacteria (57 mg N-NO3- L-1 day-1) was consumed, leading to a nitrogen removal efficiency of 97.5%. Nitrates 4-11 L1 cell adhesion molecule Homo sapiens 55-58 31382524-1 2019 : Dietary nitrate (NO3-) has been reported to improve endothelial function (EF) and blood pressure (BP). Nitrates 10-17 NBL1, DAN family BMP antagonist Homo sapiens 19-22 31172512-0 2019 A reevaluation of the contribution of NRT1.1 to nitrate uptake in Arabidopsis under low-nitrate supply. Nitrates 48-55 nitrate transporter 1.1 Arabidopsis thaliana 38-44 31175188-12 2019 The fumarate reductase FccA is a highly abundant multifunctional periplasmic protein that acts to bridge the periplasm and temporarily store electrons in a variety of respiratory nodes, including metal, nitrate, and dimethyl sulfoxide respiration. Nitrates 203-210 flavocytochrome c Shewanella oneidensis MR-1 23-27 31071559-1 2019 Nitrate (NO3-) pollution is a serious problem worldwide. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31172512-1 2019 NRT1.1 has been previously characterized as a dual-affinity nitrate transporter in Arabidopsis, though several lines of evidence have raised questions regarding its high-affinity function in nitrate uptake. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 0-6 31172512-2 2019 Here, we show that the induction of NRT2.1- and NRT2.2-mediated nitrate uptake interferes with measurements of the contribution of NRT1.1 to high-affinity uptake using nrt1.1 mutants. Nitrates 64-71 nitrate transporter 2:1 Arabidopsis thaliana 36-40 31172512-2 2019 Here, we show that the induction of NRT2.1- and NRT2.2-mediated nitrate uptake interferes with measurements of the contribution of NRT1.1 to high-affinity uptake using nrt1.1 mutants. Nitrates 64-71 nitrate transporter 2:1 Arabidopsis thaliana 48-52 31172512-4 2019 This triple mutant has a lower rate of nitrate uptake than the nrt2.1/2.2 double mutant under low external nitrate supply, resulting in a lower growth rate than that of the double mutant. Nitrates 39-46 nitrate transporter 2:1 Arabidopsis thaliana 63-67 31172512-4 2019 This triple mutant has a lower rate of nitrate uptake than the nrt2.1/2.2 double mutant under low external nitrate supply, resulting in a lower growth rate than that of the double mutant. Nitrates 107-114 nitrate transporter 2:1 Arabidopsis thaliana 63-67 31172512-5 2019 Therefore, we conclude that NRT1.1-mediated high-affinity nitrate uptake is necessary for plant growth under low-nitrate conditions. Nitrates 58-65 nitrate transporter 1.1 Arabidopsis thaliana 28-32 31172512-5 2019 Therefore, we conclude that NRT1.1-mediated high-affinity nitrate uptake is necessary for plant growth under low-nitrate conditions. Nitrates 113-120 nitrate transporter 1.1 Arabidopsis thaliana 28-32 31093850-11 2019 The nitrate/nitrite ratio was reduced in serum and in aortas of 6-month-old CD73-/- mice as compared to WT. Nitrates 4-11 5' nucleotidase, ecto Mus musculus 76-80 31306468-2 2019 The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production. Nitrates 31-38 nitric oxide synthase 2, inducible Mus musculus 55-59 31051259-1 2019 Nitrate (NO3-) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2-) by commensal bacteria in the oral cavity. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 31306468-2 2019 The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production. Nitrates 31-38 nitric oxide synthase 2, inducible Mus musculus 75-106 31306468-2 2019 The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production. Nitrates 31-38 nitric oxide synthase 2, inducible Mus musculus 108-112 31306468-6 2019 Furthermore, we show that the severity of the pathology of Salmonella- induced colitis as well as the nitrate-dependent growth of Salmonella in the lumen of the inflamed intestine are reduced in mice that lack Ccr2 and, therefore, inflammatory monocytes in the tissues. Nitrates 102-109 chemokine (C-C motif) receptor 2 Mus musculus 210-214 31251057-4 2019 The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy. Nitrates 95-102 NBL1, DAN family BMP antagonist Homo sapiens 104-107 31054393-1 2019 Denitrifying bioreactors remove nitrate (NO3-) from agricultural drainage and are slated to be an integral part of nitrogen reduction strategies in the Mississippi River Basin. Nitrates 32-39 NBL1, DAN family BMP antagonist Homo sapiens 41-44 31251057-4 2019 The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy. Nitrates 95-102 NBL1, DAN family BMP antagonist Homo sapiens 171-174 30845346-0 2019 Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure-lowering. Nitrates 72-79 insulin Homo sapiens 91-98 30845346-7 2019 CONCLUSIONS: In healthy adults, acute physiological elevations of plasma [glucose] and [insulin] result in a lack of BP-lowering with dietary nitrate. Nitrates 142-149 insulin Homo sapiens 88-95 31078007-6 2019 The presence of nitrate (NO3-) slowed the removal of ReO4- from solution, presumably through chemical reduction and precipitation. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 25-28 30986667-7 2019 Furthermore, the total ammonium (NH4+) and nitrate (NO3-) concentration in modified natural zeolite were increased by 11.1 and 21.5% respectively as compared to raw zeolite. Nitrates 43-50 NBL1, DAN family BMP antagonist Homo sapiens 52-55 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 96-103 NIN like protein 7 Arabidopsis thaliana 26-44 31095461-1 2019 Dietary nitrate ( NO3- ) supplementation has been shown to reduce resting blood pressure. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 18-21 30936488-7 2019 By contrast, Heimdallarchaeum LC2 and LC3 genomes encode enzymes potentially enabling the oxidation of organic substrates using nitrate or oxygen as electron acceptors. Nitrates 128-135 microtubule associated protein 1 light chain 3 alpha Homo sapiens 38-41 30980891-11 2019 Similarly, nitrate inhibited the overexpression of myeloperoxidase and iNOS observed under dysbiosis (p < 0.05). Nitrates 11-18 myeloperoxidase Rattus norvegicus 51-66 30980891-11 2019 Similarly, nitrate inhibited the overexpression of myeloperoxidase and iNOS observed under dysbiosis (p < 0.05). Nitrates 11-18 nitric oxide synthase 2 Rattus norvegicus 71-75 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 96-103 NIN like protein 7 Arabidopsis thaliana 46-50 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 96-103 Plant regulator RWP-RK family protein Arabidopsis thaliana 56-60 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 128-135 NIN like protein 7 Arabidopsis thaliana 26-44 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 128-135 NIN like protein 7 Arabidopsis thaliana 46-50 30903620-7 2019 The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants. Nitrates 128-135 Plant regulator RWP-RK family protein Arabidopsis thaliana 56-60 31084876-8 2019 The FT expression levels in the chl1-5flc-3 double mutant plants recovered when the FLC mutation was introduced into chl1-5 plants and the up-regulation of FLC transcripts in the chl1-5 mutant plants was not related to nitrate availability. Nitrates 219-226 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 156-159 31084876-9 2019 Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner. Nitrates 255-262 nitrate transporter 1.1 Arabidopsis thaliana 26-32 31084876-9 2019 Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner. Nitrates 255-262 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 81-84 31058993-6 2019 AtTCP20 is a plant-specific TF, which can modulate LR development in response to nitrate. Nitrates 81-88 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 0-7 31084876-9 2019 Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner. Nitrates 255-262 nitrate transporter 1.1 Arabidopsis thaliana 155-161 31084876-9 2019 Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner. Nitrates 255-262 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 246-249 31113864-5 2019 Using bone marrow-derived macrophages from WT and RIP2-KO mice, we show that loss of RIP2 leads to deficient FcgammaR signaling and reactive oxygen species (ROS) production upon FcgammaR cross-linking without affecting cytokine secretion, phagocytosis, or nitrate/nitrite production. Nitrates 256-263 receptor (TNFRSF)-interacting serine-threonine kinase 2 Mus musculus 85-89 30933788-6 2019 A day by treatment interaction was also observed on plasma methemoglobin concentrations, with concentrations being lower from steers one day after initiation of treatments than from collected one day prior to treatment initiation and concentrations being lowest in steers treated with nitrate plus 79R4. Nitrates 285-292 hemoglobin subunit gamma 2 Homo sapiens 59-72 30928741-4 2019 Across-catchment differences in upstream spring water nitrate concentrations predicted differences in annual nitrate loads at catchment outlets (range <1-72 megagrams NO3-N 365 d-1), and nitrate loads were higher in wet seasons and wet years, reflecting strong groundwater influences. Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 170-173 30928792-5 2019 Further analysis showed that ammonia-oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) in the O1 and O2 tanks together contributed to the conversion of ammonia nitrogen to nitrate, but the process of heterotrophic denitrification was inhibited in the A1 and A2 tanks because of insufficient carbon sources. Nitrates 184-191 immunoglobulin kappa variable 2D-40 Homo sapiens 106-115 30928741-7 2019 However, high nitrate loads from groundwater mean current NO3-N waterway management and rehabilitation practices targeting waterway stock exclusion by fencing alone will be insufficient to reduce annual NO3-N export. Nitrates 14-21 NBL1, DAN family BMP antagonist Homo sapiens 58-61 30943068-7 2019 siRNA knockdown of Rcn2 dramatically increased production of the nitric oxide (NO) breakdown products nitrite and nitrate by endothelial cells but not by smooth muscle cells. Nitrates 114-121 reticulocalbin 2 Mus musculus 19-23 30831514-3 2019 Batch denitrification experiments showed that nitrate was completely removed at 5 h without nitrite accumulation under the optimum conditions of COD/NO3--N concentration ratio of 5.0-5.5 and initial pH of 7.2 +- 0.1. Nitrates 46-53 NBL1, DAN family BMP antagonist Homo sapiens 149-152 30870003-2 2019 In both heart and skeletal muscle, nitrate increases fatty acid oxidation capacity, and in the latter case, this involves up-regulation of peroxisome proliferator-activated receptor (PPAR)alpha expression. Nitrates 35-42 peroxisome proliferator activated receptor alpha Mus musculus 183-193 30785000-3 2019 HPR achieved a higher nitrate removal activity (maximum:19.66 +- 0.63 mg NO3--N/(L h)) with excellent resistance to high nitrate loading (up to 400 mg/L NO3--N) compared to that of the control groups. Nitrates 22-29 haptoglobin-related protein Homo sapiens 0-3 30785000-3 2019 HPR achieved a higher nitrate removal activity (maximum:19.66 +- 0.63 mg NO3--N/(L h)) with excellent resistance to high nitrate loading (up to 400 mg/L NO3--N) compared to that of the control groups. Nitrates 121-128 haptoglobin-related protein Homo sapiens 0-3 30785000-4 2019 Nitrate removal rate of HPR fitted the Michaelis-Menten kinetic model (R2 = 0.98, p < 0.01) well, and the denitrification followed the zero-order rate law. Nitrates 0-7 haptoglobin-related protein Homo sapiens 24-27 31146317-6 2019 Additionally, the NO3-/Cl- versus Cl- diagram and principal component analysis (PCA) show that the contamination of nitrate in the study area was due to human activities (i.e. agriculture and domestic sewage disposal). Nitrates 116-123 NBL1, DAN family BMP antagonist Homo sapiens 18-21 30870003-3 2019 Here, we investigated whether dietary nitrate modifies mitochondrial function in the hypoxic heart in a PPARalpha-dependent manner. Nitrates 38-45 peroxisome proliferator activated receptor alpha Mus musculus 104-113 30870003-7 2019 This switch away from fatty acid oxidation was reversed by nitrate treatment in hypoxic WT but not Ppara-/- mice, indicating a PPARalpha-dependent effect. Nitrates 59-66 peroxisome proliferator activated receptor alpha Mus musculus 127-136 30797805-0 2019 Zr4+ ions embedded chitosan-soya bean husk activated bio-char composite beads for the recovery of nitrate and phosphate ions from aqueous solution. Nitrates 98-105 brain expressed associated with NEDD4 1 Homo sapiens 33-37 30797805-1 2019 Removal of nitrate and phosphate ions using Zr4+ ions embedded chitosan-soya bean husk activated bio-char composite beads (Zr-CS-SAC) was carried out by batch mode to overcome the environmental problems due to eutrophication. Nitrates 11-18 brain expressed associated with NEDD4 1 Homo sapiens 77-81 31019249-0 2019 Author Correction: Nitrate-NRT1.1B-SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants. Nitrates 19-26 immunoglobulin superfamily member 9 Homo sapiens 27-31 30849493-10 2019 The findings in this study that nitration of hIAPP promotes its oligomer formation and thus exacerbates its cytotoxicity suggests a possible link between the nitrite (or the sum of nitrite and nitrate) levels and T2D, and ameliorated nitration of hIAPP by diminishing nitrative stress might be a promising therapeutic strategy for T2D. Nitrates 193-200 islet amyloid polypeptide Homo sapiens 45-50 31016305-6 2019 When normalized to nitrate concentration, the denitrification rate (NDR) followed a positive trend with either the concentration or proportion of tFDOC, and a negative trend with the proportion of nFDOC, suggesting tFDOC was potentially favorable while nFDOC was unfavorable for denitrifying degradation. Nitrates 19-26 serine/threonine kinase 38 Homo sapiens 68-71 31138751-5 2019 Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Nitrates 149-156 interferon gamma Mus musculus 60-69 31138751-5 2019 Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Nitrates 149-156 signal transducer and activator of transcription 1 Mus musculus 70-75 31138751-5 2019 Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Nitrates 149-156 nitric oxide synthase 2, inducible Mus musculus 76-80 31138751-5 2019 Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness. Nitrates 149-156 nitric oxide synthase 2, inducible Mus musculus 412-416 30807951-6 2019 The higher DNF and DNRA rates observed after the addition of NOC indicates that nitrate reduction was enhanced more by NOC than acetate. Nitrates 80-87 nocturnin Homo sapiens 61-64 30807951-6 2019 The higher DNF and DNRA rates observed after the addition of NOC indicates that nitrate reduction was enhanced more by NOC than acetate. Nitrates 80-87 nocturnin Homo sapiens 119-122 31064131-5 2019 The calibration graph for nitrates was linear in the range of 0.5-35 microg mL-1 with a correlation coefficient of 0.9999. Nitrates 26-34 L1 cell adhesion molecule Mus musculus 76-80 31112557-1 2019 Nitrification, the microbial oxidation of ammonia (NH3) to nitrite (NO2-) and NO2- to nitrate (NO3-), plays a vital role in ocean nitrogen cycling. Nitrates 86-93 NBL1, DAN family BMP antagonist Homo sapiens 95-98 31064131-7 2019 The calibration graph for nitrites (after oxidation to nitrates) was linear in the range of 0.5-15 microg mL-1 with a correlation coefficient of 0.9972. Nitrates 55-63 L1 cell adhesion molecule Mus musculus 106-110 31064131-9 2019 The nitrate concentrations in the saliva samples were found in the range of 8.98-18.52 mug mL-1, whereas nitrite was in the range of 3.50-5.34 mug mL-1. Nitrates 4-11 L1 cell adhesion molecule Mus musculus 91-95 30878866-1 2019 Elimination of nitrogen pollution from wastewater containing high-strength nitrate (NO3--N) is a significant issue to prevent deterioration of water quality and eutrophication of receiving water body. Nitrates 75-82 NBL1, DAN family BMP antagonist Homo sapiens 84-87 30995881-7 2019 Tempol-treated DJ -1 -/- mice presented higher serum nitrite/nitrate levels than vehicle-treated DJ -1 -/- mice, suggesting a role of the NO system in the high blood pressure of this model. Nitrates 61-68 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 15-20 30995881-10 2019 The renal-selective silencing of Ucp2 led to normalization of blood pressure and serum nitrite/nitrate ratio in DJ -1 -/- mice. Nitrates 95-102 uncoupling protein 2 (mitochondrial, proton carrier) Mus musculus 33-37 30763914-5 2019 Especially, the L20 resin with the triethylammonium functional group was demonstrated to possess high selectivity toward nitrate with the highest distribution coefficient among all tested resins. Nitrates 121-128 immunoglobulin kappa variable 3D-11 Homo sapiens 16-19 30763914-7 2019 The L20 resin could be reused after many adsorption-desorption cycles with most of its virgin adsorption capacity for advanced wastewater treatment, indicating its great potential for the selective and efficient removal of nitrate from large amounts of municipal wastewater or surface water. Nitrates 223-230 immunoglobulin kappa variable 3D-11 Homo sapiens 4-7 30776171-1 2019 Increasing nitrogen (N) deposition in subtropical forests in south China causes N saturation, associated with significant nitrate (NO3 - ) leaching. Nitrates 122-129 NBL1, DAN family BMP antagonist Homo sapiens 131-134 30784837-1 2019 Nitrate (NO3-) is a key component of secondary inorganic aerosols and PM2.5. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 30772502-9 2019 Nitrate restored decreased red blood cells count, hemoglobin concentration, and hematocrit to control levels in diabetic rats; in addition, nitrate restored decreased serum, kidney, and liver EPO levels to near normal values. Nitrates 140-147 erythropoietin Rattus norvegicus 192-195 30822646-1 2019 Nitrate (NO3-N) export from row crop agricultural systems with subsurface tile drainage continues to be a major water quality concern. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 30772502-12 2019 CONCLUSION: Long-term and low dose of nitrate had beneficial effects against anemia in obese type 2 diabetic rats; these effects were associated with increased EPO and HIF-1 levels in kidney and liver as well as increased circulating EPO, testosterone, and iron. Nitrates 38-45 erythropoietin Rattus norvegicus 160-163 30772502-12 2019 CONCLUSION: Long-term and low dose of nitrate had beneficial effects against anemia in obese type 2 diabetic rats; these effects were associated with increased EPO and HIF-1 levels in kidney and liver as well as increased circulating EPO, testosterone, and iron. Nitrates 38-45 erythropoietin Rattus norvegicus 234-237 31087918-5 2019 The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2. Nitrates 83-90 Putative anthocyanidin reductase Zea mays 338-342 30967583-0 2019 GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis. Nitrates 33-40 G-protein-coupled receptor 1 Arabidopsis thaliana 0-4 30967583-0 2019 GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis. Nitrates 33-40 G protein alpha subunit 1 Arabidopsis thaliana 9-13 30967583-7 2019 Physiological and molecular validation of nitrate-response revealed the sensitivity of germination to low N in the double mutant and differential expression of nitrate transporter (and nitrate reductase in all three mutants). Nitrates 42-49 nitrate reductase 1 Arabidopsis thaliana 185-202 31087918-5 2019 The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2. Nitrates 191-198 Putative anthocyanidin reductase Zea mays 241-245 31087918-5 2019 The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2. Nitrates 191-198 Putative anthocyanidin reductase Zea mays 241-245 31087918-8 2019 In summary, the results showed that the nitrate nitrogen leaching values were 10.5, 59.9, and 136.5 kg hm-2 for nitrogen fertilizer applications of 0, 300, and 450 kg hm-2, respectively, during extreme precipitation in a wet year (2015). Nitrates 40-47 Putative anthocyanidin reductase Zea mays 103-107 31087918-8 2019 In summary, the results showed that the nitrate nitrogen leaching values were 10.5, 59.9, and 136.5 kg hm-2 for nitrogen fertilizer applications of 0, 300, and 450 kg hm-2, respectively, during extreme precipitation in a wet year (2015). Nitrates 40-47 Putative anthocyanidin reductase Zea mays 167-171 31087918-9 2019 The value of nitrate nitrogen leaching in the maize season of 2013 (dry year), 2015 (normal year), and 2016 (wet year) accounted for 9%, 10%, and 20% for the 300 kg hm-2 of nitrogen fertilizer applied, respectively. Nitrates 13-20 Putative anthocyanidin reductase Zea mays 165-169 31087918-10 2019 However, the value of nitrate nitrogen leaching in the maize season of 2013 (dry year), 2015 (normal year), and 2016 (wet year) accounted for 11%, 17% and 30% of the 450 kg hm-2 of nitrogen fertilizer applied. Nitrates 22-29 Putative anthocyanidin reductase Zea mays 173-177 30935372-3 2019 Plant chloride channels (CLCs) are transport proteins for anions including Cl- and nitrate (NO3-), and are critical for nutrition uptake and transport, adjustment of cellular turgor, stomatal movement, signal transduction, and Cl- and NO3- homeostasis under salt stress. Nitrates 83-90 NBL1, DAN family BMP antagonist S homeolog Xenopus laevis 92-95 31087940-4 2019 The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form. Nitrates 174-181 L1 cell adhesion molecule Homo sapiens 164-167 31087940-4 2019 The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form. Nitrates 174-181 NBL1, DAN family BMP antagonist Homo sapiens 183-186 31087940-4 2019 The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form. Nitrates 174-181 L1 cell adhesion molecule Homo sapiens 164-167 30055294-3 2019 Nitrate improves tissue oxygenation and has been shown to modulate skeletal muscle tissue metabolism via transcriptional changes, including through the activation of peroxisome proliferator-activated receptor alpha (PPARalpha), a master regulator of fat metabolism. Nitrates 0-7 peroxisome proliferator activated receptor alpha Mus musculus 166-214 30055294-3 2019 Nitrate improves tissue oxygenation and has been shown to modulate skeletal muscle tissue metabolism via transcriptional changes, including through the activation of peroxisome proliferator-activated receptor alpha (PPARalpha), a master regulator of fat metabolism. Nitrates 0-7 peroxisome proliferator activated receptor alpha Mus musculus 216-225 30670112-0 2019 Dietary nitrate consumption and risk of CHD in women from the Nurses" Health Study. Nitrates 8-15 choline dehydrogenase Homo sapiens 40-43 30670112-3 2019 Therefore, the aim of this investigation was to examine the relationship between habitual dietary nitrate intakes and risk of CHD in women from the Nurses" Health Study. Nitrates 98-105 choline dehydrogenase Homo sapiens 126-129 30670112-9 2019 When comparing the highest quintile of nitrate intake with the lowest quintile, in aged-adjusted analysis there was a protective association for CHD (RR=0 77, 95 % CI 0 68, 0 97; P=0 0002) which dissipated after further adjustment for smoking, physical activity, BMI and race (RR=0 91; 95 % CI 0 80, 1 04; P=0 27). Nitrates 39-46 choline dehydrogenase Homo sapiens 145-148 30869514-5 2019 NMR titration studies suggest that only 1:1 complexes of Ln(III) with C2-POPhen formed in CH3OH in the presence of a significant amount of nitrate, while both 1:1 and 2:1 complexes species could form between C2-POPhen and Ln(III) perchlorate in CH3OH without nitrate ions. Nitrates 139-146 complement C2 Homo sapiens 70-79 30641379-2 2019 The nitrate removal rate of the AnFB-MBR reached 1.22 g NO3--N L-1d-1 with NO3--N ranging 40-200 mg L-1 at hydraulic retention times of 1.0-5.0 h. The denitrification in the integrated system was simultaneously carried out by sulfur- and Fe0-oxidizing autotrophic denitrifiers. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 56-59 31049136-1 2019 Nitrate (NO3 -) supplementation is associated with exercise performance, oxygen uptake, blood flow, and blood pressure improvement, and it can act as an antioxidant agent. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 30712424-0 2019 Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity. Nitrates 8-15 angiotensinogen Rattus norvegicus 52-66 30712424-4 2019 In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension. Nitrates 61-68 angiotensinogen Rattus norvegicus 154-160 30712424-4 2019 In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension. Nitrates 61-68 angiotensinogen Rattus norvegicus 162-176 30712424-9 2019 Supplementation with nitrate normalized the expression of AT1Rs in rostral ventrolateral medulla and reduced sympathetic nerve activity, which was associated with attenuated development of hypertension. Nitrates 21-28 angiotensin II receptor, type 1a Rattus norvegicus 58-61 30685420-1 2019 Dietary nitrate (NO3-) supplementation via beetroot juice (BR) is known to improve endurance performance in untrained and moderately trained individuals. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 30972097-0 2019 NRT1.1 Regulates Nitrate Allocation and Cadmium Tolerance in Arabidopsis. Nitrates 17-24 nitrate transporter 1.1 Arabidopsis thaliana 0-4 30968014-4 2019 Results indicate that nitrate can be removed from source waters using FCDI to concentrations <1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1). Nitrates 22-29 immunoglobulin kappa variable 1-16 Homo sapiens 108-111 30622055-4 2019 This work examines the effect of aluminum (Al) incorporation (0%, 12% and 24 mol% Al) on the interaction energy of chloride (Cl-) and nitrate (NO3-), and adsorption/desorption of sulfate (SO42-) onto Fh. Nitrates 134-141 NBL1, DAN family BMP antagonist Homo sapiens 143-146 30894123-1 2019 BACKGROUND: Nutrition with ammonium (NH4+) can enhance the drought tolerance of rice seedlings in comparison to nutrition with nitrate (NO3-). Nitrates 127-134 NBL1, DAN family BMP antagonist Homo sapiens 136-139 30968014-4 2019 Results indicate that nitrate can be removed from source waters using FCDI to concentrations <1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1). Nitrates 22-29 immunoglobulin kappa variable 1-16 Homo sapiens 156-159 30968014-4 2019 Results indicate that nitrate can be removed from source waters using FCDI to concentrations <1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1). Nitrates 22-29 immunoglobulin kappa variable 1-16 Homo sapiens 156-159 30458235-11 2019 Gene expression of Bax and caspase 3 was decreased in both the lung and submandibular gland with nitrate treatment, indicating attenuation of apoptosis. Nitrates 97-104 BCL2-associated X protein Mus musculus 19-22 30884848-1 2019 Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite. Nitrates 106-113 nitrate reductase 1 Arabidopsis thaliana 0-17 30884848-1 2019 Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite. Nitrates 166-173 nitrate reductase 1 Arabidopsis thaliana 0-17 30458235-11 2019 Gene expression of Bax and caspase 3 was decreased in both the lung and submandibular gland with nitrate treatment, indicating attenuation of apoptosis. Nitrates 97-104 caspase 3 Mus musculus 27-36 30617465-1 2019 PURPOSE: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 30865649-2 2019 In this study we use small flux chambers to examine ammonium (NH4+) and nitrate (NO3-) cycling across the sediment-water interface. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 30508798-2 2019 For the first time, mag-LDHs were applied to sonocatalytic reduction of nitrate (NO3-) and the reduction mechanism were determined by conducting kinetic tests and various spectroscopic analyses. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 30617465-3 2019 METHODS: In a randomised, counterbalanced, double-blind crossover study, 12 recreationally trained males ingested a nitrate-rich beetroot juice shot (BRJ) (6.2 mmol NO3-) or a nitrate-depleted placebo (PLA) (< 0.004 mmol NO3-) 3 h prior to an intermittent sprint test (IST) in temperate (22 C, 35% RH) and hot conditions (30 C, 70% RH). Nitrates 116-123 alcohol dehydrogenase iron containing 1 Homo sapiens 145-148 30645747-12 2019 NO3- concentration showed a linear relationship of excess NH4+, which suggests homogeneous gas-phase reaction of ammonia and nitric acid is possibly an important pathways of nitrate formation in the haze pollution process in Shenyang City. Nitrates 174-181 NBL1, DAN family BMP antagonist Homo sapiens 0-3 30234781-12 2019 Furthermore, abnormal expression of DLK1-MEG3 expression was caused by hypermethylation status of IG-DMR, And methylation status of IG-DMR highly correlated with ET1 concentration and nitrate concentration, these might be one of the mechanisms for impaired endothelial function (coefficient = 0.5806, P = 0.0115; coefficient = -0.4883, P = 0.0398). Nitrates 184-191 delta like non-canonical Notch ligand 1 Homo sapiens 36-40 30611943-4 2019 Non-sea-salt sulfate (nss-SO42-) constituted the major component of PM2.5, followed by ammonium (NH4+) and nitrate (NO3-) during winter, summer and autumn. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 116-119 30234781-12 2019 Furthermore, abnormal expression of DLK1-MEG3 expression was caused by hypermethylation status of IG-DMR, And methylation status of IG-DMR highly correlated with ET1 concentration and nitrate concentration, these might be one of the mechanisms for impaired endothelial function (coefficient = 0.5806, P = 0.0115; coefficient = -0.4883, P = 0.0398). Nitrates 184-191 maternally expressed 3 Homo sapiens 41-45 30699248-7 2019 COD/NO3- -N ratio mainly controlled the rate of nitrate reduction and not directly partial denitrification selection; thus, it should be used to balance between denitrification rate and anammox rate. Nitrates 48-55 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 0-3 30699248-7 2019 COD/NO3- -N ratio mainly controlled the rate of nitrate reduction and not directly partial denitrification selection; thus, it should be used to balance between denitrification rate and anammox rate. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 4-7 30759603-1 2019 Recent studies have identified aerosol nitrate (NO3-) as one of the most important inorganic ions; however, quantitative studies of aerosol NO3- sources are rarely undertaken. Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 48-51 30819094-6 2019 Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants. Nitrates 178-185 NIN like protein 7 Arabidopsis thaliana 31-35 30819094-6 2019 Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants. Nitrates 178-185 NIN like protein 7 Arabidopsis thaliana 162-166 30819094-6 2019 Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants. Nitrates 178-185 NIN like protein 7 Arabidopsis thaliana 232-236 30676746-1 2019 Microbial strains and indigenous microbiota in soil slurries have been reported to use electrons from electrodes for nitrate (NO3-) reduction. Nitrates 117-124 NBL1, DAN family BMP antagonist Homo sapiens 126-129 30359797-4 2019 At one RSC, with high nitrate (NO3-) inputs, retention of N (16-37%) and release of DOC (18-54%) were observed with the highest retention of N during summer, and the rates of N retention and DOC release were larger than that of the adjacent unrestored tributary (N: 5-8%, DOC: <18%). Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 31-34 30223219-5 2019 Our results showed that all three tree species preferred ammonium (NH4+) over glycine and nitrate (NO3-), and NH4+ contributed 73% to the total N uptake from the soil. Nitrates 90-97 NBL1, DAN family BMP antagonist Homo sapiens 99-102 30777103-4 2019 METHODS: The influences of endogenous and exogenous H2S on the expression of IDO1, iNOS and NF-kappaB and STAT3 signaling proteins were investigated using qPCR or western blot, and the production of nitric oxide (NO) was analyzed by nitrate/nitrite assay in Cse-/- mice and MCF-7 and SGC-7901 cells. Nitrates 233-240 histocompatibility 2, S region (C4, Slp, Bf, C2) Mus musculus 52-55 30326455-1 2019 Nitrate isotopes (delta15N-NO3- and delta18O-NO3-) are a potentially powerful tool for tracking the biological removal of reactive nitrogen (N) as it is transported from land to sea. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 27-30 30326455-1 2019 Nitrate isotopes (delta15N-NO3- and delta18O-NO3-) are a potentially powerful tool for tracking the biological removal of reactive nitrogen (N) as it is transported from land to sea. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 45-48 30605314-1 2019 Measurements of the stable isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3-) enable identification of sources, dispersal, and fate of natural and contaminant NO3- in aquatic environments. Nitrates 88-95 NBL1, DAN family BMP antagonist Homo sapiens 97-100 30605314-1 2019 Measurements of the stable isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3-) enable identification of sources, dispersal, and fate of natural and contaminant NO3- in aquatic environments. Nitrates 88-95 NBL1, DAN family BMP antagonist Homo sapiens 184-187 30551041-1 2019 In this study, the synergy of high nitrite (NO2--N) accumulated partial-denitrification (PD) and anammox in a continuously fed upflow anaerobic sludge blanket (UASB) reactor was verified for simultaneous nitrate (NO3--N) and ammonia (NH4+-N) removal. Nitrates 204-211 NBL1, DAN family BMP antagonist Homo sapiens 213-216 30624978-9 2019 Plasma nitrate-nitrite levels increased in IL-4-treated RUPP rats, while placental preproendothelin-1 expression, plasma TNF-alpha and IL-6, and AT1-AA decreased in IL-4-treated RUPP rats compared with untreated RUPP rats ( P < 0.05). Nitrates 7-14 interleukin 4 Rattus norvegicus 43-47 30604360-4 2019 We found that the application of Ca2+ could regulate the activity of plasma membrane H+-ATPase, for mitigating the increase of ammonium and the decrease of nitrate and phosphorus in soybean roots, which mitigated the inhibition on growth and improved the yield and grain quality of soybean under simulated acid rain stress. Nitrates 156-163 plasma membrane ATPase 4 Glycine max 85-94 30180321-2 2019 In particular, nitrate concentrations exceeding the 50 mg L-1 limit established for drinking water pose the human health at risk. Nitrates 15-22 L1 cell adhesion molecule Homo sapiens 58-61 30407574-6 2019 More importantly, our data demonstrate that, when cultivated under full nitrate conditions, known to repress N remobilization due to sufficient N uptake from the soil, N remobilization efficiency can nevertheless be sharply and significantly increased by overexpressing ATG8 genomic sequences under the control of the ubiquitin promoter. Nitrates 72-79 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 270-274 31459405-6 2019 This study evaluates the predictive capabilities of various ab initio methods in the calculation of Gibbs free energies of reaction for [Ln(NO3)]2+ compounds (with Ln = La to Lu), as nitrates are critical in traditional separation processes utilizing nitric acid. Nitrates 183-191 NBL1, DAN family BMP antagonist Homo sapiens 140-143 30180321-12 2019 Nitrate was not homogeneously distributed in groundwater, being observed a large range of concentrations, from <1 up to 162 mg L-1. Nitrates 0-7 L1 cell adhesion molecule Homo sapiens 130-133 30565947-2 2019 Herein, a selective surface defect elimination process with the help of hydrated nitrates was introduced into the perovskite/toluene solution to strip the undesired surface defects and vacancies and to boost the photoluminescence quantum yield of true-blue-light-emitting (at 466 nm) CsPb(Cl/Br)3 perovskite nanocrystals to the impressive value of 85%. Nitrates 81-89 granzyme B Homo sapiens 284-288 30559212-7 2019 Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed to nitrite-derived formation of NO species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to mediate the reduction of nitrite. Nitrates 51-58 xanthine dehydrogenase Homo sapiens 180-203 29672839-7 2019 Inhibition of cyclooxygenase 1 by aspirin, supplementation of PGI2 by beraprost, and inhibition of PGIS S-nitrosylation by N-acetyl-cysteine improved GTN-induced nitrate cross-tolerance in rats. Nitrates 162-169 prostaglandin-endoperoxide synthase 1 Rattus norvegicus 14-30 29672839-0 2019 S-Nitrosylation of Prostacyclin Synthase Instigates Nitrate Cross-Tolerance In Vivo. Nitrates 52-59 prostaglandin I2 synthase Homo sapiens 19-40 29672839-7 2019 Inhibition of cyclooxygenase 1 by aspirin, supplementation of PGI2 by beraprost, and inhibition of PGIS S-nitrosylation by N-acetyl-cysteine improved GTN-induced nitrate cross-tolerance in rats. Nitrates 162-169 prostaglandin I2 synthase Rattus norvegicus 99-103 29672839-3 2019 This study aimed to determine the role of PGIS S-nitrosylation in nitrate tolerance induced by nitroglycerin (GTN). Nitrates 66-73 prostaglandin I2 synthase Homo sapiens 42-46 29672839-8 2019 In patients, increased PGIS S-nitrosylation was associated with nitrate tolerance. Nitrates 64-71 prostaglandin I2 synthase Homo sapiens 23-27 29672839-9 2019 In conclusion, GTN induces nitrate cross-tolerance through PGIS S-nitrosylation at cysteine 231/441. Nitrates 27-34 prostaglandin I2 synthase Homo sapiens 59-63 29672839-6 2019 Enforced expression of mutated PGIS with C231/441A markedly abolished GTN-induced PGIS S-nitrosylation and nitrate cross-tolerance in Apoe-/- mice. Nitrates 107-114 prostaglandin I2 (prostacyclin) synthase Mus musculus 31-35 30312509-1 2019 Forest harvest in the boreal zone can increase the input of terrestrial materials such as dissolved organic carbon (DOC) and nitrate (NO3 - ) into nearby aquatic ecosystems, with potential effects on phytoplankton growth through enhanced nutrient (i.e., positive) or reduced light availability (i.e., negative), which may affect ecosystem productivity and consumer resource use. Nitrates 125-132 NBL1, DAN family BMP antagonist Homo sapiens 134-137 29529688-5 2019 The concentration of myeloperoxidase was determined by enzyme-linked immunosorbent assay, the concentration of nitrate and nitrite with high performance liquid chromatography method. Nitrates 111-118 myeloperoxidase Homo sapiens 21-36 29529688-7 2019 RESULTS: The mean concentration of myeloperoxidase was significantly higher in the diabetic group compared to the control group (16.2+-4.9 vs. 3.7+-1.8; P<0.001).The nitrite concentration was comparable in both groups while the concentration of nitrate was significantly higher in the diabetic group (41.2 [42.9] vs 31.9 [23]; P=0.017). Nitrates 248-255 myeloperoxidase Homo sapiens 35-50 29529688-8 2019 In this study, plasma myeloperoxidase (Spearman"s rho=0.421; P=0.004) and nitrate concentration was significantly positively associated with the HbA1c levels while nitrate concentration (Spearman"s rho=- 0.308; P=0.047) were was significantly positively negatively associated with the HbA1c levels. Nitrates 164-171 myeloperoxidase Homo sapiens 22-37 31844504-4 2019 The impact on wet deposition of nitrate is assessed using measurements from the National Atmospheric Deposition Program"s National Trends Network (NADP NTN). Nitrates 32-39 neurturin Homo sapiens 152-155 28803424-6 2019 Sharp increases in the nitrate concentration in surface water were related to the accumulation of contaminants in the soil and aeration zone during drought periods and the subsequent transport of these contaminants to groundwater and surface water via recharge infiltration after each drought period. Nitrates 23-30 spen family transcriptional repressor Homo sapiens 0-5 30526064-8 2019 Arginase-1 was negatively correlated with serum nitrite and nitrate (r = -0.8137 and r = -0.8444, respectively). Nitrates 60-67 arginase 1 Homo sapiens 0-10 33828349-5 2019 Estimates obtained from the parametric g-formula, a marginal structural model, and a structural nested model indicate that chlorophyll a concentrations at Lock and Dam 1 were influenced by nitrate concentrations measured 86 to 109 km upstream, an area where four major industrial and municipal point sources discharge wastewater. Nitrates 189-196 BCAS2 pre-mRNA processing factor Homo sapiens 164-169 30847325-1 2019 Background: The aim of this study was calibration of a nitrate (NO3)/nitrite (NO2) database for estimated its dietary intakes. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 64-67 31328626-7 2019 Ammonia and nitrate were effectively removed by both adsorption materials resulting in a reduction of influent ammonia and nitrate concentrations to below the national discharge limits set for these compounds of <=4 mg L-1 and <=50 mg L-1, respectively. Nitrates 12-19 immunoglobulin kappa variable 1-16 Homo sapiens 222-225 30502887-6 2019 The results of a classification and regression tree (CART) model indicate the difference in the influence of physical factors on groundwater nitrate concentrations between western and eastern Nebraska, namely that groundwater nitrate concentrations correspond with vadose zone thickness, effective hydraulic conductivity, and saturated thickness in the west, while in eastern Nebraska, concentrations are correlated with average percent sand in the topsoil (0-150 cm), well depth, and effective hydraulic conductivity. Nitrates 226-233 CART prepropeptide Homo sapiens 53-57 31328626-7 2019 Ammonia and nitrate were effectively removed by both adsorption materials resulting in a reduction of influent ammonia and nitrate concentrations to below the national discharge limits set for these compounds of <=4 mg L-1 and <=50 mg L-1, respectively. Nitrates 12-19 immunoglobulin kappa variable 1-16 Homo sapiens 241-244 31438763-3 2019 We recently found how nitrate, present at the shoot apical meristem (SAM), controls flowering time In this short communication, we present data on the tissue-specific expression patterns of NITRATE REDUCTASE 1 (NIA1) and NIA2 in planta. Nitrates 22-29 nitrate reductase 1 Arabidopsis thaliana 211-215 31438763-3 2019 We recently found how nitrate, present at the shoot apical meristem (SAM), controls flowering time In this short communication, we present data on the tissue-specific expression patterns of NITRATE REDUCTASE 1 (NIA1) and NIA2 in planta. Nitrates 22-29 nitrate reductase 2 Arabidopsis thaliana 221-225 30064106-6 2019 The results of nitrate isotopes indicated that NO3- mainly originated from soil organic nitrogen (SON), chemical fertilizer (CF), and manure and sewage wastes (M&S). Nitrates 15-22 NBL1, DAN family BMP antagonist Homo sapiens 47-50 30064106-7 2019 The negative correlation of nitrate isotopic values with NO3-/Cl- ratios suggested the importance of denitrification in NO3- loss. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 57-60 30064106-7 2019 The negative correlation of nitrate isotopic values with NO3-/Cl- ratios suggested the importance of denitrification in NO3- loss. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 120-123 30064106-11 2019 The seasonal pattern of nitrate dynamics indicated the mixing of nitrified NO3- and denitrified NO3- between surface flow and groundwater flow under different hydrological conditions. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 75-78 30064106-11 2019 The seasonal pattern of nitrate dynamics indicated the mixing of nitrified NO3- and denitrified NO3- between surface flow and groundwater flow under different hydrological conditions. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 96-99 30687454-4 2018 Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes. Nitrates 29-37 interleukin 6 Homo sapiens 110-123 30396103-1 2019 Nitrogen (N) removal in conventional bioretention systems is highly variable owing to the low nitrate (NO3-) elimination efficiency. Nitrates 94-101 NBL1, DAN family BMP antagonist Homo sapiens 103-106 30583575-1 2018 The commercial P25 titania has been modified with transition metallic species (Cr, Co, Ni, and Cu), added by impregnation with aqueous solutions of the corresponding nitrates. Nitrates 166-174 tubulin polymerization promoting protein Homo sapiens 15-18 30530699-2 2018 These layers of heightened chlorophyll and/or phytoplankton concentrations are generally thought to be a consequence of a balance between light energy from above and a limiting nutrient flux from below, typically nitrate (NO3). Nitrates 213-220 NBL1, DAN family BMP antagonist Homo sapiens 222-225 30461282-6 2018 The experimental phase behavior shows that while the chloride salts induce both liquid-liquid phase separation (LLPS) and RC, the nitrate salts also induce LLPS, but RC becomes partial with La(NO3)3 and disappears with Y(NO3)3. Nitrates 130-137 NBL1, DAN family BMP antagonist Homo sapiens 193-196 30461282-6 2018 The experimental phase behavior shows that while the chloride salts induce both liquid-liquid phase separation (LLPS) and RC, the nitrate salts also induce LLPS, but RC becomes partial with La(NO3)3 and disappears with Y(NO3)3. Nitrates 130-137 NBL1, DAN family BMP antagonist Homo sapiens 221-224 30628384-4 2018 The main sources of nitrate pollution in the area were determined by means of 15N(NO3-) and 18O(NO3-) isotopes. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 82-85 31458367-0 2018 Highly Active and Durable Cu x Au(1-x) Ultrathin-Film Catalysts for Nitrate Electroreduction Synthesized by Surface-Limited Redox Replacement. Nitrates 68-75 cut like homeobox 1 Homo sapiens 26-30 31458367-1 2018 Cu x Au(1-x) bimetallic ultrathin-film catalysts for nitrate electroreduction have been synthesized using electrochemical atomic layer deposition by surface-limited redox replacement of Pb underpotentially deposited layer. Nitrates 53-60 cut like homeobox 1 Homo sapiens 0-4 31458367-4 2018 The synthesized Cu x Au(1-x) thin films feature up to two times higher nitrate electroreduction activity in acidic solution compared to bulk and thin-film Cu counterparts. Nitrates 71-78 cut like homeobox 1 Homo sapiens 16-20 30628384-4 2018 The main sources of nitrate pollution in the area were determined by means of 15N(NO3-) and 18O(NO3-) isotopes. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 96-99 30628384-7 2018 The results show that there are three main factors affecting the nitrate concentration in the study area:animal manure and domestic sewage, NO3- in chemical fertilizer, and soil nitrogen. Nitrates 65-72 NBL1, DAN family BMP antagonist Homo sapiens 140-143 30223124-3 2018 The required HRT to reach 98.5% COD removal was achieved at 7.5 h. Simultaneous CNP removal under denitrification rate of 199.4 mg/l.d gave high nitrate to nitrogen gas conversion of 74.6 mg/l. Nitrates 145-152 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 80-83 30088840-13 2018 Nitrate treatment in diabetic rats significantly improved sperm parameters, epididymal weight, spermatogenesis and testicular histology as well as decreasing serum glucose and testicular p53 gene and miR-34b expression, although it had no effect on serum LH and FSH levels. Nitrates 0-7 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 187-190 30145415-0 2018 Fabrication and characterization of a Cu-Pd-TNPs polymetallic nanoelectrode for electrochemically removing nitrate from groundwater. Nitrates 107-114 C1GALT1 specific chaperone 1 Homo sapiens 44-48 30145415-1 2018 A novel Cu-Pd-TNPs (Copper-Palladium-TiO2 Nanopores) polymetallic nanoelectrode was fabricated, and then used to catalytically reduce dissolved nitrate in groundwater. Nitrates 144-151 C1GALT1 specific chaperone 1 Homo sapiens 14-18 30145415-7 2018 The Cu-Pd-TNPs electrode gave a high nitrate reduction rate, removing 287.3% nitrate more than that was removed by a Ti nanoelectrode under the same conditions. Nitrates 37-44 C1GALT1 specific chaperone 1 Homo sapiens 10-14 30145415-7 2018 The Cu-Pd-TNPs electrode gave a high nitrate reduction rate, removing 287.3% nitrate more than that was removed by a Ti nanoelectrode under the same conditions. Nitrates 77-84 C1GALT1 specific chaperone 1 Homo sapiens 10-14 30145415-9 2018 Nitrate was completely removed using the Cu-Pd-TNPs electrode with a Pt anode at a NaCl concentration of 0.5 g L-1, little ammonia and almost no nitrite were detected in the treated solution. Nitrates 0-7 C1GALT1 specific chaperone 1 Homo sapiens 47-51 30408861-2 2018 Nitrate was the most abundant ion in PM2.5 and substantially increased during haze pollution with the NO3-/SO42- mass ratio increasing from 0.78 during clean period to 1.1 during haze period. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 102-105 30408869-4 2018 In general, the N2O emission fluxes were positively correlated to nitrate (NO3-) concentrations in soil solution, supporting the important role of denitrification in N2O production, which was also modified by environmental factors such as soil temperature and moisture. Nitrates 66-73 NBL1, DAN family BMP antagonist Homo sapiens 75-78 30088840-13 2018 Nitrate treatment in diabetic rats significantly improved sperm parameters, epididymal weight, spermatogenesis and testicular histology as well as decreasing serum glucose and testicular p53 gene and miR-34b expression, although it had no effect on serum LH and FSH levels. Nitrates 0-7 microRNA 34b Rattus norvegicus 200-207 30359537-4 2018 During a training session, plasma [ NO3- ] ( P < 0.001) and plasma [ NO2- ] ( P < 0.01) were higher in nitrate (N), whereas in pre- and posttests mean plasma [ NO3- ] and [ NO2- ] were not different between groups. Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 36-39 30216785-10 2018 Our results demonstrate that high anthocyanin accumulation in PAP1-D/fls1ko plants confers enhanced tolerance to nitrate-deficient conditions combined with high salinity. Nitrates 113-120 lipin 1 Homo sapiens 62-66 30216785-11 2018 PAP1-D/fls1ko plants appeared to use absorbed nitrate efficiently during the nitrate reduction process. Nitrates 46-53 lipin 1 Homo sapiens 0-4 30216785-11 2018 PAP1-D/fls1ko plants appeared to use absorbed nitrate efficiently during the nitrate reduction process. Nitrates 77-84 lipin 1 Homo sapiens 0-4 30216785-12 2018 In addition, nitrate-related genes such as NRT1.1, NiA1 and NiA2 were upregulated in the PAP1-D/fls1ko plants. Nitrates 13-20 lipin 1 Homo sapiens 89-93 30138958-3 2018 METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3). Nitrates 9-16 NBL1, DAN family BMP antagonist Homo sapiens 27-30 30337453-10 2018 This study showed that NH4 + toxicity is related to a nitrate-independent signaling function of NRT1.1 in Arabidopsis, characterized by enhanced NH4 + accumulation and altered NH4 + metabolism, which stimulates ethylene synthesis, leading to plant senescence. Nitrates 54-61 nitrate transporter 1.1 Arabidopsis thaliana 96-102 30138958-3 2018 METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3). Nitrates 9-16 Src like adaptor Homo sapiens 216-220 30138958-3 2018 METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3). Nitrates 9-16 NBL1, DAN family BMP antagonist Homo sapiens 289-292 30085380-1 2018 RATIONALE: The stable nitrogen isotopic composition of nitrate (NO3 - ) can be an effective tool to identify NO3 - sources and understand nitrogen cycling. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 64-67 30284450-3 2018 Herein, we demonstrate the use of LIG, created with a low-cost UV laser, for electrochemical ion-selective sensing of plant-available nitrogen (i.e., both ammonium and nitrate ions: NH4+ and NO3-) in soil samples. Nitrates 168-175 NBL1, DAN family BMP antagonist Homo sapiens 191-194 30085380-1 2018 RATIONALE: The stable nitrogen isotopic composition of nitrate (NO3 - ) can be an effective tool to identify NO3 - sources and understand nitrogen cycling. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 109-112 30182316-3 2018 The results revealed that nitrate leaching over the entire crop growing season in Chinese vegetable systems was very high and averaged 79.1 kg N ha-1 and primarily resulted from extremely high N fertilizer inputs (in average 423 kg N ha-1). Nitrates 26-33 solute carrier family 9 member B1 Homo sapiens 143-149 29902768-1 2018 Energy-rich bonds such as nitrates (NO3-) and percholorates (ClO4-) have an explosive nature; they are frequently encountered in high energy materials. Nitrates 26-34 NBL1, DAN family BMP antagonist Homo sapiens 36-39 30182316-3 2018 The results revealed that nitrate leaching over the entire crop growing season in Chinese vegetable systems was very high and averaged 79.1 kg N ha-1 and primarily resulted from extremely high N fertilizer inputs (in average 423 kg N ha-1). Nitrates 26-33 solute carrier family 9 member B1 Homo sapiens 232-238 30182316-4 2018 Nitrate leaching was, on the average, 63.9% greater in the greenhouse systems (98.0 kg N ha-1) than in open-field systems (59.8 kg N ha-1). Nitrates 0-7 solute carrier family 9 member B1 Homo sapiens 87-93 30182316-4 2018 Nitrate leaching was, on the average, 63.9% greater in the greenhouse systems (98.0 kg N ha-1) than in open-field systems (59.8 kg N ha-1). Nitrates 0-7 solute carrier family 9 member B1 Homo sapiens 131-137 30242656-1 2018 Identification and quantification of sources of nitrate (NO3-) in freshwater lakes provide useful information for management of eutrophication and improving water quality in lakes. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 57-60 28818018-5 2018 The best conditions found for the treatment - with satisfactory reduction of nitrate, formation of gaseous compounds and reproducibility - were at nitrate concentrations of 600 and 1000 mg L-1, current density of 1.1 mA cm-2 and without pH control, since in these conditions the production of gaseous compounds is higher than the production of nitrite. Nitrates 147-154 immunoglobulin kappa variable 1-16 Homo sapiens 189-192 30113272-1 2018 Studies of rats have indicated that skeletal muscle plays a central role in whole-body nitrate ( NO3- )/nitrite ( NO2- )/nitric oxide (NO) metabolism. Nitrates 87-94 NBL1, DAN family BMP antagonist Homo sapiens 97-100 30190419-0 2018 Early Senescence in Older Leaves of Low Nitrate-Grown Atxdh1 Uncovers a Role for Purine Catabolism in N Supply. Nitrates 40-47 xanthine dehydrogenase 1 Arabidopsis thaliana 54-60 30190419-3 2018 Older leaves of the Atxdh1 mutant exhibited early senescence, lower soluble protein, and lower organic N levels as compared with wild-type older leaves when grown with 1 mm nitrate but were comparable to the wild type under 5 mm nitrate. Nitrates 173-180 xanthine dehydrogenase 1 Arabidopsis thaliana 20-26 30190419-3 2018 Older leaves of the Atxdh1 mutant exhibited early senescence, lower soluble protein, and lower organic N levels as compared with wild-type older leaves when grown with 1 mm nitrate but were comparable to the wild type under 5 mm nitrate. Nitrates 229-236 xanthine dehydrogenase 1 Arabidopsis thaliana 20-26 30190419-8 2018 The higher nitrate reductase activity in Atxdh1 leaves compared with wild-type leaves indicated a need for nitrate assimilation products. Nitrates 11-18 xanthine dehydrogenase 1 Arabidopsis thaliana 41-47 30388086-3 2018 The mass specific area of the sulfur particles (a*) and hydrolysis kinetic constant (k1) were identified as the dominant parameters on the model outputs, i.e. nitrate (NO3-), NO2- and sulfate (SO42-) concentrations, confirming that the microbially catalyzed S0 hydrolysis is the rate-limiting step during S0-driven denitrification. Nitrates 159-166 NBL1, DAN family BMP antagonist Homo sapiens 168-171 30584441-1 2018 Context: We describe here the contributions of the Tehran lipid and glucose study (TLGS) to understanding different aspects of the nitrate (NO3)-nitrite (NO2)-nitric oxide (NO) pathway in health and disease. Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 30099301-5 2018 The nitrate ion concentration increase with time is consistent with a two-rate system-level model that is characterized by two asymptotic rates for NO3- creation by the plasma. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 148-151 30099301-9 2018 While both system-level models have some discrepancies with the measurements, the two-rate model based on the nitrate ion concentration is concluded to be more useful for determining the NO3- formation rates in the context of irrigation water enrichment. Nitrates 110-117 NBL1, DAN family BMP antagonist Homo sapiens 187-190 30205097-6 2018 KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats. Nitrates 55-62 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 265-268 30205097-6 2018 KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats. Nitrates 55-62 programmed cell death 4 Rattus norvegicus 270-275 30205097-6 2018 KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats. Nitrates 55-62 phosphofurin acidic cluster sorting protein 2 Rattus norvegicus 281-286 30205097-6 2018 KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats. Nitrates 55-62 microRNA 449a Rattus norvegicus 385-393 30229602-2 2018 From May to October 2017, six sampling points in the Qingmuguan river basin, Chongqing, were monitored every 24 d. Results showed that there was a great risk of nitrate pollution in the underground river system, because most NO3--N concentrations of the sampling points exceeded the threshold. Nitrates 161-168 NBL1, DAN family BMP antagonist Homo sapiens 225-228 29860169-5 2018 In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+ recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides. Nitrates 187-194 NBL1, DAN family BMP antagonist Homo sapiens 164-167 29860169-5 2018 In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+ recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides. Nitrates 187-194 NBL1, DAN family BMP antagonist Homo sapiens 205-208 30229602-12 2018 It is believed that soil organic nitrogen, NH4+ in fertilizer and rain, the mixing of manure and sewage, and NO3- in precipitation were the main nitrate sources in the outlet. Nitrates 145-152 NBL1, DAN family BMP antagonist Homo sapiens 109-112 29886338-1 2018 Nitrate (NO3-) pollution in rivers caused by intensive human activities is becoming a serious problem in irrigated agricultural areas. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 30271668-1 2018 The source of dietary nitrate (NO3) is mainly green, leafy vegetables, partially absorbed into blood through intestinal mucosa. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 31-34 30271668-3 2018 In 2012, sialin was first discovered as the mammalian membrane nitrate transporter in salivary glands and plays a key role in circulation of inorganic nitrate, providing a scientific basis for further investigation into the circulation and functions of nitrate. Nitrates 63-70 solute carrier family 17 member 5 Homo sapiens 9-15 30271668-3 2018 In 2012, sialin was first discovered as the mammalian membrane nitrate transporter in salivary glands and plays a key role in circulation of inorganic nitrate, providing a scientific basis for further investigation into the circulation and functions of nitrate. Nitrates 151-158 solute carrier family 17 member 5 Homo sapiens 9-15 29906753-7 2018 At HRT of 30 min, the NO3- removal efficiency could achieve above 90% with the nitrate-to-nitrite transformation ratio of 0.8, implying the great potential to apply the thiosulfate-driven denitratation & anammox system for BNR with minimal sludge production. Nitrates 79-86 NBL1, DAN family BMP antagonist Homo sapiens 22-25 29960262-7 2018 We observed that water-soluble inorganic ions, especially nitrate (NO3-) and ammonium, had stronger influences on 3 hormones. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 29913387-3 2018 Stable isotope values of nitrate (delta15NNO3-, delta18ONO3-) can complement conventional water quality monitoring programs to help differentiate natural sources of NO3- from anthropogenic inputs and estimate the processes involved in N cycling within an ecosystem. Nitrates 25-32 NBL1, DAN family BMP antagonist Homo sapiens 42-45 29860091-3 2018 Also, this review focuses on the development of electrochemical label-free immunosensor for SOD1 and the recent advances in biosensing assay methods based on their catalytic and biological functions with various substrates including reactive oxygen species (superoxide anion radical, hydrogen peroxide), nitric oxide metabolites (nitrite, nitrate) and thiols using thiol oxidase activity. Nitrates 339-346 superoxide dismutase 1 Homo sapiens 92-96 29913387-10 2018 After consideration of potential alternative sources (sewage, atmospheric deposition and groundwater) we concluded that there are three plausible interpretations for deviations from conservative mixing behaviour (1) NO3- uptake by assimilation (2) in situ NO3- production (from fixation-derived nitrogen and nitrification of sewage-derived effluents) and (3) input of groundwater nitrate carrying a denitrification signal. Nitrates 380-387 NBL1, DAN family BMP antagonist Homo sapiens 256-259 30344609-6 2018 The limit of detection (LOD) and the limit of quantification (LOQ) at 3sigma for hydroxylamine nitrate ranged from 0.3 to 3 and from 3.5 to 10 g L-1, respectively, for the nitrate system at three peaks with wavelengths between 3.8 and 9.8 mum. Nitrates 95-102 immunoglobulin kappa variable 1-16 Homo sapiens 145-148 30371202-11 2018 This suggests that sGC downregulation occurs outside the renal vasculature, increases renal sodium retention, and contributes to nitrate resistance of sunitinib-induced hypertension. Nitrates 129-136 guanylate cyclase 1 soluble subunit alpha 1 Rattus norvegicus 19-22 30294630-1 2018 The presence of elevated nitrate (NO3-) and nitrite (NO2-) concentration in drinking water higher than the standard limits could endanger the health of consumers. Nitrates 25-32 NBL1, DAN family BMP antagonist Homo sapiens 34-37 30229313-5 2018 Prior studies show how nitrites and nitrates in red meat can lead to increased insulin resistance, dysregulated blood glucose levels, and elevated oxidative stress all leading to chronic diseases. Nitrates 36-44 insulin Homo sapiens 79-86 29727854-7 2018 The increase in the water table depth (from 10 to 30 m) and the decrease of the nitrate concentration (from 25 to 15 mg NO3--N) would lead to a rise in energy consumption in the ex situ treatment. Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 120-123 30294630-8 2018 Although, the average concentration of NO3- and NO2- in drinking water was lower than the national standard limits, but the non-carcinogenic risk assessment showed that the children and adults are at a significant risk via nitrate and nitrite in the rural Divandarreh County (TTHQ > 1). Nitrates 223-230 NBL1, DAN family BMP antagonist Homo sapiens 39-42 30188067-4 2018 Due to biological metabolism, the generation of methane in sewers was of 7.39 mg L-1; the decrease of nitrate and sulfate in sewage was 0.33 mg L-1 and 21.35 mg L-1, respectively. Nitrates 102-109 immunoglobulin kappa variable 1-16 Homo sapiens 144-147 30188067-4 2018 Due to biological metabolism, the generation of methane in sewers was of 7.39 mg L-1; the decrease of nitrate and sulfate in sewage was 0.33 mg L-1 and 21.35 mg L-1, respectively. Nitrates 102-109 immunoglobulin kappa variable 1-16 Homo sapiens 144-147 30063337-2 2018 With hydroquinone (BQH2) and 1,4-benzoquinone (BQ) as redox mediators, the photochemical oxidation of As(III) and reduction of nitrate (NO3-) was carefully investigated. Nitrates 127-134 NBL1, DAN family BMP antagonist Homo sapiens 136-139 29894929-7 2018 Interestingly, the PhP under study were biodegraded even in the absence of additional carbon source, with 85% of ciprofloxacin removed under sulfate-reducing conditions and 62% and 83% of ciprofloxacin and estradiol removed, respectively, under nitrate-reducing conditions. Nitrates 245-252 N-acylsphingosine amidohydrolase 1 Homo sapiens 19-22 30010841-6 2018 Redundancy analysis identified positive correlations of nitrate, Escherichia coli, and coliforms with tet(W) and intI1 genes in sediment and intI1, sul1 and tet(W) genes in water. Nitrates 56-63 IntI1 Escherichia coli 113-118 29957358-1 2018 This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0. Nitrates 101-108 cytochrome c, somatic Equus caballus 173-185 29957358-1 2018 This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0. Nitrates 101-108 cytochrome c, somatic Equus caballus 187-192 29777853-7 2018 Vitellogenin concentrations were slightly elevated in males (but not females) in all of the groups exposed to nitrate. Nitrates 110-117 vitellogenin Danio rerio 0-12 30111737-0 2018 Variations in Dissolved Nitrate, Chloride, and Sulfate in Precipitation, Reservoir, and Tap Waters, Columbus, Ohio. Nitrates 24-31 nuclear RNA export factor 1 Homo sapiens 88-91 30099933-1 2018 BACKGROUND:: Ingestion of nitrate (NO3-)-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP). Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 35-38 29998683-6 2018 Nitrate on the resin could be completely biodegraded within 10 h when the inoculum amount (measured as VSS) was higher than 0.6 g L-1. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 130-133 30040397-2 2018 Density functional theory (B3LYP) and relativistic multireference (CASPT2) calculations confirmed the AnO2(NO3)2- as AnVO2+ actinyl moieties coordinated by nitrates. Nitrates 156-164 anoctamin 2 Homo sapiens 102-106 30040397-2 2018 Density functional theory (B3LYP) and relativistic multireference (CASPT2) calculations confirmed the AnO2(NO3)2- as AnVO2+ actinyl moieties coordinated by nitrates. Nitrates 156-164 NBL1, DAN family BMP antagonist Homo sapiens 107-110 30310628-0 2018 The coordination chemistry of CmIII, AmIII, and AcIII in nitrate solutions: an actinide L3-edge EXAFS study. Nitrates 57-64 adenylate cyclase 3 Homo sapiens 48-53 30131697-9 2018 The endothelial nitric oxide synthase (eNOS) protein and myocardial nitrate/nitrite were impaired in the heart of diabetic rats, which, however, were restored after PKK treatment. Nitrates 68-75 kallikrein 1-related peptidase B3 Rattus norvegicus 165-168 29931366-1 2018 Campylobacter jejuni, a human gastrointestinal pathogen, uses nitrate for growth under microaerophilic conditions using periplasmic nitrate reductase (Nap). Nitrates 62-69 catenin beta like 1 Homo sapiens 151-154 29704850-7 2018 The NH4+/NO3- experiment result demonstrated that ammonia and nitrate did convert into N2 during SCWO, however, the formation of N2 was little without auxiliary fuel. Nitrates 62-69 NBL1, DAN family BMP antagonist Homo sapiens 9-12 30082037-1 2018 Agricultural contamination of groundwater with nitrate (NO3-) is one of the most widespread and pressing environmental issues. Nitrates 47-54 NBL1, DAN family BMP antagonist Homo sapiens 56-59 29524892-1 2018 The feasibility of using Feammox coupled with nitrate-dependent Fe(II) oxidizing (NAFO) to cause the simultaneous conversion of NH4+ and NO3- was explored by inoculation with Feammox sludge and the use Fe cycling as catalyst. Nitrates 46-53 NBL1, DAN family BMP antagonist Homo sapiens 137-140 29722627-9 2018 Deoxygenated [hemoglobin + myoglobin] was not different for 40% peak ( P > 0.05) but was elevated throughout 85% peak ( P < 0.05) after nitrate. Nitrates 136-143 myoglobin Homo sapiens 27-36 29864505-4 2018 Additionally, since NO bioavailability can be improved with exogenous nitrate (NO3-) via the nitrate-nitrite-NO pathway, we tested the hypothesis that inorganic NO3- supplementation would reduce BP responses to muscle metaboreflex activation in healthy older adults. Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 79-82 29864505-4 2018 Additionally, since NO bioavailability can be improved with exogenous nitrate (NO3-) via the nitrate-nitrite-NO pathway, we tested the hypothesis that inorganic NO3- supplementation would reduce BP responses to muscle metaboreflex activation in healthy older adults. Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 161-164 29533800-2 2018 Nonetheless, in the freshwater-saltwater interface of endorheic saline lakes, oxidation-reduction (redox) reactions can attenuate pollutants such as nitrate (NO3-). Nitrates 149-156 NBL1, DAN family BMP antagonist Homo sapiens 158-161 29802192-9 2018 The balance between internally and externally available electron acceptors (nitrate) and electron donors (reduced sulfur) likely controlled the end product of nitrate reduction both between orange and white FLSB mats and between different spatial and geochemical niches within the white FLSB mat.IMPORTANCE Whether large sulfur bacteria of the family Beggiatoaceae reduce NO3 - to N2 via denitrification or to NH4 + via DNRA has been debated in the literature for more than 25 years. Nitrates 159-166 NBL1, DAN family BMP antagonist Homo sapiens 372-375 29431644-1 2018 BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS). Nitrates 12-20 prostaglandin I2 synthase Homo sapiens 166-191 29431644-1 2018 BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS). Nitrates 12-20 prostaglandin I2 synthase Homo sapiens 193-198 29431644-1 2018 BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS). Nitrates 117-124 prostaglandin I2 synthase Homo sapiens 166-191 29431644-1 2018 BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS). Nitrates 117-124 prostaglandin I2 synthase Homo sapiens 193-198 29431644-3 2018 The aim of this study was to determine whether nitrates induce nitrovasodilator resistance via microRNA-dependent repression of PTGIS gene expression. Nitrates 47-55 prostaglandin I2 synthase Homo sapiens 128-133 30042774-4 2018 AtNPF6.3 has traditionally been characterized as a dual-affinity nitrate transporter contributing to root nitrate uptake in Arabidopsis. Nitrates 65-72 nitrate transporter 1.1 Arabidopsis thaliana 0-8 30042774-5 2018 It has also been identified as a nitrate sensor which regulates the expression of high-affinity nitrate transport proteins NRT2s and lateral root development as a part of the primary nitrate response in plants. Nitrates 33-40 nitrate transporter 2:1 Arabidopsis thaliana 123-127 30042774-5 2018 It has also been identified as a nitrate sensor which regulates the expression of high-affinity nitrate transport proteins NRT2s and lateral root development as a part of the primary nitrate response in plants. Nitrates 96-103 nitrate transporter 2:1 Arabidopsis thaliana 123-127 30042774-9 2018 The review will investigate from a structural point of view how NPF6.3-like proteins may transport nitrate as well as other ions and what can be learned from structural uniqueness about predicted activities in plants. Nitrates 99-106 nitrate transporter 1.1 Arabidopsis thaliana 64-70 29514014-6 2018 In the base condition, the PM2.5 mass concentrations were found to increase 15% from the background, whereas the nitrate (NO3-) content had a significant increase at the campus site. Nitrates 113-120 NBL1, DAN family BMP antagonist Homo sapiens 122-125 29736649-2 2018 The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1, with mean values of 0.059 +- 0.014 and 5.25 +- 1.61 mg L-1, respectively. Nitrates 16-23 immunoglobulin kappa variable 1-16 Homo sapiens 100-103 29702279-12 2018 HO-1 played important roles in the down-regulation of superoxide levels in lung tissues by cordycepin, and HO-1 expression induced by cordycepin affected nitrite and nitrate concentrations in plasma and iNOS protein expression in lung tissues. Nitrates 166-173 heme oxygenase 1 Rattus norvegicus 107-111 29785845-1 2018 This work demonstrates bromate (BrO3-) reduction in a methane (CH4)-based membrane biofilm reactor (MBfR), and it documents contrasting impacts of nitrate (NO3-) on BrO3- reduction, as well as formation of poly-beta-hydroxybutyrate (PHB), an internal C- and electron-storage material. Nitrates 147-154 NBL1, DAN family BMP antagonist Homo sapiens 156-159 29534920-9 2018 TGF-beta correlated directly with nitrite and nitrate and inversely to other inflammatory factors. Nitrates 46-53 transforming growth factor beta 1 Homo sapiens 0-8 29973922-15 2018 A flavin-based electron confurcating (FBEC) HdrABC complex is proposed for nitrate-dependent reverse methanogenesis in which the oxidation of CoM-SH/CoB-SH and Fdx2- is coupled to reduction of F420. Nitrates 75-82 ferredoxin 2 Homo sapiens 160-164 29550729-1 2018 Denitrifying enhanced biological phosphorus removal (EBPR) systems can be an efficient means of removing phosphate (P) and nitrate (NO3-) with low carbon source and oxygen requirements. Nitrates 123-130 NBL1, DAN family BMP antagonist Homo sapiens 132-135 29676902-4 2018 An exception might be represented by the cases (rather rare in paddies) of quite high nitrate concentration (around 50 mg of NO3- L-1), when DCA degradation by CO3 - would play a comparable role to that by direct photolysis. Nitrates 86-93 NBL1, DAN family BMP antagonist Homo sapiens 125-128 28593806-2 2018 DHS-USB systems can perform nitrification and denitrification simultaneously, reducing ammonia (NH3) and nitrate (NO3-) toxicity in the water. Nitrates 105-112 NBL1, DAN family BMP antagonist Homo sapiens 114-117 29541882-5 2018 Quantitative reverse transcription polymerase chain reaction analysis indicated high expression levels of the nitrate transporter genes, especially NRT2.1, which plays a major role in the high-affinity nitrate transport system in roots. Nitrates 110-117 nitrate transporter 2:1 Arabidopsis thaliana 148-154 29860377-9 2018 This, according to the level of total soluble sugars, can be explained by the existence of a cross-talk between the sugars in excess and low nitrate in the medium that blocks the activity of nitrate reductase in stressful sugar conditions until the plant is adapted to the stress. Nitrates 141-148 nitrate reductase 1 Arabidopsis thaliana 191-208 29875779-2 2018 Although ammonium (NH4+) is the main N source for rice, nitrate (NO3-) is also absorbed and utilized. Nitrates 56-63 NBL1, DAN family BMP antagonist Homo sapiens 65-68 29938022-3 2018 Experimental investigations, supported by electronic structure calculations, reveal that catalysis commences when nitrate binds to the two-electron reduced species CoII(DIM-), where cobalt and the macrocycle are each reduced by a single electron. Nitrates 114-121 mitochondrially encoded cytochrome c oxidase II Homo sapiens 164-168 29563255-4 2018 Cav-1 small interfering RNA (siRNA) reduced eNOS protein and gene expression in association with a twofold increase in eNOS phosphorylation and nitrate production per molecule of eNOS, which was reversed in cells overexpressing Adv-Cav-1-GFP. Nitrates 144-151 caveolin 1 Homo sapiens 0-5 29706511-0 2018 A Tandem Amino Acid Residue Motif in Guard Cell SLAC1 Anion Channel of Grasses Allows for the Control of Stomatal Aperture by Nitrate. Nitrates 126-133 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 48-53 29748645-7 2018 The network analysis also identified HUB transcription factors like mTERF, FHA, Orphan, bZip and FAR1, which may be the key regulators of nitrate-mediated response in B. juncea. Nitrates 138-145 tripartite motif-containing 17 Mus musculus 68-73 29706511-10 2018 When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel. Nitrates 18-25 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 56-61 29706511-10 2018 When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel. Nitrates 18-25 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 101-108 29706511-10 2018 When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel. Nitrates 142-149 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 56-61 29706511-10 2018 When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel. Nitrates 142-149 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 101-108 29732470-3 2018 This study aimed to improve nitrate (NO3) load estimates using high-resolution records (15-min time interval) from optical sensors to capture the typical concentration response to storm events. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 37-40 29780398-0 2018 FIP1 Plays an Important Role in Nitrate Signaling and Regulates CIPK8 and CIPK23 Expression in Arabidopsis. Nitrates 32-39 FH interacting protein 1 Arabidopsis thaliana 0-4 29965503-3 2018 It was shown that nitrogen pollution, which was dominated by nitrate (NO3-), existed in the four reservoirs. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 29780398-3 2018 Here, we report that the FIP1 gene (factor interacting with poly(A) polymerase 1) plays an important role in nitrate signaling in Arabidopsis thaliana. Nitrates 109-116 FH interacting protein 1 Arabidopsis thaliana 25-29 29780398-5 2018 We found that FIP1 interacts with the cleavage and polyadenylation specificity factor 30-L (CPSF30-L), which is also an essential player in nitrate signaling. Nitrates 140-147 FH interacting protein 1 Arabidopsis thaliana 14-18 29780398-5 2018 We found that FIP1 interacts with the cleavage and polyadenylation specificity factor 30-L (CPSF30-L), which is also an essential player in nitrate signaling. Nitrates 140-147 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 92-98 29780398-6 2018 The induction of nitrate-responsive genes following nitrate treatment was inhibited in the fip1 mutant. Nitrates 17-24 FH interacting protein 1 Arabidopsis thaliana 91-95 29780398-6 2018 The induction of nitrate-responsive genes following nitrate treatment was inhibited in the fip1 mutant. Nitrates 52-59 FH interacting protein 1 Arabidopsis thaliana 91-95 29780398-7 2018 The nitrate content was also reduced in fip1 seedlings due to their decreased nitrate uptake activity. Nitrates 4-11 FH interacting protein 1 Arabidopsis thaliana 40-44 29780398-7 2018 The nitrate content was also reduced in fip1 seedlings due to their decreased nitrate uptake activity. Nitrates 78-85 FH interacting protein 1 Arabidopsis thaliana 40-44 29780398-8 2018 Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes. Nitrates 17-24 FH interacting protein 1 Arabidopsis thaliana 83-87 29780398-8 2018 Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes. Nitrates 17-24 NITRATE TRANSPORTER 1.8 Arabidopsis thaliana 133-139 29780398-8 2018 Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes. Nitrates 168-175 FH interacting protein 1 Arabidopsis thaliana 83-87 29780398-9 2018 In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling. Nitrates 135-142 FH interacting protein 1 Arabidopsis thaliana 41-45 29780398-9 2018 In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling. Nitrates 135-142 CBL-interacting protein kinase 8 Arabidopsis thaliana 85-90 29780398-9 2018 In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling. Nitrates 135-142 CBL-interacting protein kinase 23 Arabidopsis thaliana 95-101 29780398-10 2018 In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content. Nitrates 66-73 FH interacting protein 1 Arabidopsis thaliana 7-11 29780398-10 2018 In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content. Nitrates 66-73 CBL-interacting protein kinase 23 Arabidopsis thaliana 48-54 29780398-10 2018 In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content. Nitrates 105-112 FH interacting protein 1 Arabidopsis thaliana 7-11 29780398-10 2018 In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content. Nitrates 105-112 CBL-interacting protein kinase 23 Arabidopsis thaliana 48-54 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 FH interacting protein 1 Arabidopsis thaliana 45-49 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 54-60 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 FH interacting protein 1 Arabidopsis thaliana 116-120 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 170-176 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 CBL-interacting protein kinase 8 Arabidopsis thaliana 201-206 29780398-11 2018 Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23. Nitrates 84-91 CBL-interacting protein kinase 23 Arabidopsis thaliana 211-217 29432804-11 2018 RESULTS: Nitrate supplementation in diabetic rats significantly improved glucose tolerance, lipid profiles, and catalase activity as well as decreased gluconeogenesis, fasting glucose, insulin, and IL-1beta; although it had no significant effect on GSIS, islet insulin content, HbA1c, and serum TBARS. Nitrates 9-16 interleukin 1 beta Rattus norvegicus 198-206 29428615-5 2018 NO3- (from HPAM oxidation) as electron acceptors stimulated the activities of nitrate-reducing, acetate-producing and methanogenic microorganisms and they could form a synergistic effect on denitrification and methanogenesis. Nitrates 78-85 NBL1, DAN family BMP antagonist Homo sapiens 0-3 29795728-1 2018 Dietary nitrate (NO3-) has been shown to reduce oxygen consumption (VO2) during moderate to high-intensity (e.g. time to fatigue, time trials) exercise and often in trained athletes. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 29378248-2 2018 Mice with a NOS1 knockout have markedly reduced muscle nitrate levels, suggesting NO production by NOS and its reaction with oxymyoglobin as a source of nitrate. Nitrates 55-62 nitric oxide synthase 1, neuronal Mus musculus 12-16 29378248-2 2018 Mice with a NOS1 knockout have markedly reduced muscle nitrate levels, suggesting NO production by NOS and its reaction with oxymyoglobin as a source of nitrate. Nitrates 153-160 nitric oxide synthase 1, neuronal Mus musculus 12-16 29432804-13 2018 In diabetic rats, nitrate administration increased GLUT4 mRNA expression and protein levels in both soleus muscle (215% and 17%, respectively) and epididymal adipose tissue (344% and 22%, respectively). Nitrates 18-25 solute carrier family 2 member 4 Rattus norvegicus 51-56 29432804-14 2018 In diabetic rats, nitrate significantly decreased elevated iNOS mRNA expression in both the soleus muscle and epididymal adipose tissue. Nitrates 18-25 nitric oxide synthase 2 Rattus norvegicus 59-63 29432804-15 2018 CONCLUSION: Chronic nitrate supplementation in obese type 2 diabetic rats improved glucose tolerance, insulin resistance, and dyslipidemia; these favorable effects were associated with increased mRNA and protein expression of GLUT4 and decreased mRNA expression of iNOS in insulin-sensitive tissues, and with decreased gluconeogenesis, inflammation, and oxidative stress. Nitrates 20-27 solute carrier family 2 member 4 Rattus norvegicus 226-231 29432804-15 2018 CONCLUSION: Chronic nitrate supplementation in obese type 2 diabetic rats improved glucose tolerance, insulin resistance, and dyslipidemia; these favorable effects were associated with increased mRNA and protein expression of GLUT4 and decreased mRNA expression of iNOS in insulin-sensitive tissues, and with decreased gluconeogenesis, inflammation, and oxidative stress. Nitrates 20-27 nitric oxide synthase 2 Rattus norvegicus 265-269 30428377-0 2018 Adaptive Regulation of Nitrate Transceptor NRT1.1 in Fluctuating Soil Nitrate Conditions. Nitrates 23-30 immunoglobulin superfamily member 9 Homo sapiens 43-47 29570365-6 2018 In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency. Nitrates 58-65 immunoglobulin superfamily member 9 Homo sapiens 41-45 29570365-6 2018 In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency. Nitrates 77-84 immunoglobulin superfamily member 9 Homo sapiens 41-45 29570365-6 2018 In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency. Nitrates 77-84 immunoglobulin superfamily member 9 Homo sapiens 41-45 30428377-0 2018 Adaptive Regulation of Nitrate Transceptor NRT1.1 in Fluctuating Soil Nitrate Conditions. Nitrates 70-77 immunoglobulin superfamily member 9 Homo sapiens 43-47 30428377-3 2018 It has recently been reported that many of these responses are regulated by a transceptor NRT1.1, a transporter cum receptor of nitrate signaling. Nitrates 128-135 immunoglobulin superfamily member 9 Homo sapiens 90-94 30428377-4 2018 NRT1.1 displays dual-affinity modes of nitrate binding and establishes phosphorylated/non-phosphorylated states at the amino acid residue threonine 101 in response to fluctuating nitrate concentrations. Nitrates 39-46 immunoglobulin superfamily member 9 Homo sapiens 0-4 30428377-4 2018 NRT1.1 displays dual-affinity modes of nitrate binding and establishes phosphorylated/non-phosphorylated states at the amino acid residue threonine 101 in response to fluctuating nitrate concentrations. Nitrates 179-186 immunoglobulin superfamily member 9 Homo sapiens 0-4 30428377-5 2018 Here we report that intrinsic structural asymmetries between the protomers of the homodimer NRT1.1 provide a functional basis for having dual-affinity modes of nitrate binding and play a pivotal role for the phosphorylation switch. Nitrates 160-167 immunoglobulin superfamily member 9 Homo sapiens 92-96 31020121-4 2018 Coronary angiography revealed focal coronary vasospasm in the proximal LCx, well responsive for intracoronary nitrates. Nitrates 110-118 tet methylcytosine dioxygenase 1 Homo sapiens 71-74 29376168-6 2018 Relationships between Hg variables and ancillary biogeochemistry suggest that Hg methylation is carried out by sulfate reducing bacteria, but that the process is modulated by the supply of IHg substrate, sediment total and labile organic carbon, and possibly competition with nitrate reducers. Nitrates 276-283 IHG1 Homo sapiens 189-192 29438701-8 2018 SL-CLP enhanced nitrate/nitrite (NOx) concentrations in the MAB of WT, but not iNOS-deficient mice. Nitrates 16-23 leucine-rich repeat LGI family, member 4 Mus musculus 3-6 29427942-5 2018 In E25 release, nitrate reduction was largely responsible for BTEX and ethanol biodegradation, as intended. Nitrates 16-23 integral membrane protein 2C Homo sapiens 3-6 29649183-4 2018 Gene expression ratios of nitrate vs. the control were highly enhanced for those probesets related to nitrate transport and assimilation and carbon metabolism in the roots, but much less so in the nodules, except for the nitrate transport and asparagine synthetase. Nitrates 26-33 asparagine synthetase Glycine max 243-264 29662028-6 2018 Nitrate did not affect the subcellular localization of the NRs, but it caused AtSIZ1 to move from the nucleus to the cytoplasm. Nitrates 0-7 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 78-84 29636481-4 2018 Here we identify NIGT1 transcriptional repressors as negative regulators of the Arabidopsis NRT2.1 nitrate transporter gene, and show antagonistic regulation by NLP primary transcription factors for nitrate signalling and the NLP-NIGT1 transcriptional cascade-mediated repression. Nitrates 99-106 nitrate transporter 2:1 Arabidopsis thaliana 92-98 29636481-6 2018 Genome-wide analysis reveals that this mechanism is applicable to NRT2.1 and other genes involved in nitrate assimilation, hormone biosynthesis and transcription. Nitrates 101-108 nitrate transporter 2:1 Arabidopsis thaliana 66-72 29636481-7 2018 Furthermore, the PHR1 master regulator of the phosphorus-starvation response also directly promotes expression of NIGT1 family genes, leading to reductions in nitrate uptake. Nitrates 159-166 photolyase 1 Arabidopsis thaliana 17-21 29964983-2 2018 Results show that the nitrate concentrations range from 0.46 to 18.48 mg L-1, with an average of 6.18 mg L-1, and that the nitrate levels are low during the dry season. Nitrates 22-29 immunoglobulin kappa variable 1-16 Homo sapiens 73-76 29964983-2 2018 Results show that the nitrate concentrations range from 0.46 to 18.48 mg L-1, with an average of 6.18 mg L-1, and that the nitrate levels are low during the dry season. Nitrates 22-29 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 29516298-3 2018 Taking advantage of the capacity of cytochrome c (cyt c) to bind anions on its protein surface, the commercially available bCyt c was crystallized without extra purifications, using ammonium sulfate as precipitant and nitrate ions as additives. Nitrates 218-225 LOC104968582 Bos taurus 50-55 29510032-1 2018 The main objective of this study is to examine how the charge densities of four monovalent anions-fluoride (F-), chloride (Cl-), bromide (Br-), and nitrate (NO3-)-influence their Donnan (charge) exclusion by a charged nanofiltration (NF) membrane. Nitrates 148-155 NBL1, DAN family BMP antagonist Homo sapiens 157-160 29175273-4 2018 The results showed that the proposed system removes 800mgL-1 nitrate up to 95% during 6.5h. Nitrates 61-68 LLGL scribble cell polarity complex component 1 Homo sapiens 55-60 29175692-2 2018 In this paper, we attempt to give a theoretical interpretation of sulfate/nitrate reducing bacteria (SRB/NRB)-assisted cracking using Ee-pH diagrams. Nitrates 74-81 chaperonin containing TCP1 subunit 4 Homo sapiens 101-104 29175692-5 2018 Nitrate is a far more potent oxidant than sulfate, and thus, the NRB-assisted cracking of iron is a more thermodynamically favorable process than the SRB-assisted cracking. Nitrates 0-7 chaperonin containing TCP1 subunit 4 Homo sapiens 150-153 29334654-4 2018 Results indicated that an average nitrate removal efficiency of 99% could be achieved with an influent NO3--N concentration of 100 mg L-1 and a hydraulic retention time (HRT) of 7.25 h. Mass balance model predicted that 80% of the PHBV polymers were consumed by denitrifying bacteria, close to 72% consumption in real condition, suggesting the model might be useful for PHBV polymers management in BPD system. Nitrates 34-41 immunoglobulin kappa variable 1-16 Homo sapiens 134-137 29392604-1 2018 Seepage faces, the outer rim of subterranean estuaries, are an important reaction node for SGD-borne nitrate (NO3-) on a global scale. Nitrates 101-108 NBL1, DAN family BMP antagonist Homo sapiens 110-113 29407609-7 2018 Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s). Nitrates 10-17 uncharacterized protein Chlamydomonas reinhardtii 51-55 29407609-7 2018 Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s). Nitrates 10-17 uncharacterized protein Chlamydomonas reinhardtii 91-95 29407609-7 2018 Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s). Nitrates 10-17 uncharacterized protein Chlamydomonas reinhardtii 177-181 29407609-7 2018 Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s). Nitrates 10-17 uncharacterized protein Chlamydomonas reinhardtii 245-249 29762848-11 2018 CXCR3 siRNA significantly reduced nitrate level in chondrocytes induced by IL-beta (35.22 +- 1.76 vs. 17.82 +- 0.89, p<0.05) without affecting cell apoptosis (1.13 +- 0.05 vs. 0.859 +- 0.04, p>0.05). Nitrates 34-41 C-X-C motif chemokine receptor 3 Homo sapiens 0-5 29762848-12 2018 CXCR3 siRNA markedly downregulated nitrate level in chondrocytes (50.63 +- 2.53 vs. 30.63 +- 1.63, p<0.05) and alleviated cell apoptosis induced by SNP (1.98 +- 0.10 vs. 1.25 +- 0.06, p<0.05). Nitrates 35-42 C-X-C motif chemokine receptor 3 Homo sapiens 0-5 29680555-2 2018 Average values of nitrate (NO3-), dissolved silica (DSi) and phosphate (PO43-) is 2.09 mg/l, 12.7 mg/l and 0.16 mg/l in wet season and 0.47 mg/l, 6.96 mg/l and 0.29 mg/l in dry season respectively. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 29736108-6 2018 Treatment with nitrates calcium, calcium channel blockers and antiplatelet in the basis of ACS is highly indicated. Nitrates 15-23 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 91-94 29356324-0 2018 Kinetic Analysis and Structural Interpretation of Competitive Ligand Binding for NO Dioxygenation in Truncated Hemoglobin N. The conversion of nitric oxide (NO) into nitrate (NO3- ) by dioxygenation protects cells from lethal NO. Nitrates 166-173 NBL1, DAN family BMP antagonist Homo sapiens 175-178 29358221-0 2018 Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance. Nitrates 174-181 aldehyde dehydrogenase 2 family member Homo sapiens 61-85 29358221-1 2018 According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Nitrates 92-99 aldehyde dehydrogenase 2 family member Homo sapiens 41-65 29358221-1 2018 According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols. Nitrates 92-99 aldehyde dehydrogenase 2 family member Homo sapiens 67-72 29540568-4 2018 While nitrate (NO3-) is a major N form used by plants worldwide, it is discounted as a N source for Arctic tundra plants because of extremely low NO3- concentrations in Arctic tundra soils, undetectable soil nitrification, and plant-tissue NO3- that is typically below detection limits. Nitrates 6-13 NBL1, DAN family BMP antagonist Homo sapiens 15-18 29540568-6 2018 Nitrate assimilation determined by 15N enrichments of leaf NO3- relative to soil NO3- accounted for 4 to 52% (as estimated by a Bayesian isotope-mixing model) of species-specific total leaf N of Alaskan tundra plants. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 59-62 29540568-6 2018 Nitrate assimilation determined by 15N enrichments of leaf NO3- relative to soil NO3- accounted for 4 to 52% (as estimated by a Bayesian isotope-mixing model) of species-specific total leaf N of Alaskan tundra plants. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 81-84 29555906-3 2018 Here we find that N2O flux can be predicted by models incorporating soil nitrate concentration (NO3-), water content and temperature using a global field survey of N2O emissions and potential driving factors across a wide range of organic soils. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 96-99 29281085-10 2018 Whether these proteases play a back-up role in nutrient recycling and remobilization in atg mutants or act to promote cell death is discussed in relation to their accumulation patterns in the atg5 mutant compared with the salicylic acid-depleted atg5/sid2 double-mutant, and in low nitrate compared with high nitrate conditions. Nitrates 282-289 autophagy protein Apg5 family Arabidopsis thaliana 192-196 29126024-4 2018 The delta15N-NO3- and delta34S-SO42- values were more enriched by approximately 37% and 15% in the LPS than the overlying HPS associated with substantial reductions of the NO3- and SO42- concentration, indicating the occurrence of strong bio-reductions in nitrate and sulfate. Nitrates 256-263 NBL1, DAN family BMP antagonist Homo sapiens 13-16 29281085-10 2018 Whether these proteases play a back-up role in nutrient recycling and remobilization in atg mutants or act to promote cell death is discussed in relation to their accumulation patterns in the atg5 mutant compared with the salicylic acid-depleted atg5/sid2 double-mutant, and in low nitrate compared with high nitrate conditions. Nitrates 309-316 autophagy protein Apg5 family Arabidopsis thaliana 192-196 29518046-8 2018 Co-expression-network analysis of TFs with closely related profiles to known Nitrate-responsive genes identified GLK5, GLK8 and NLP15 as candidate regulators of genes repressed under low Nitrogen conditions, while bZIP108 might play a role in gene activation. Nitrates 77-84 Transcription factor NIGT1 Zea mays 113-117 29965484-9 2018 The nitrate reduction bacteria were Pseudomonas and Clostridia when the nitrate concentration was 200 mg L-1. Nitrates 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 29965484-9 2018 The nitrate reduction bacteria were Pseudomonas and Clostridia when the nitrate concentration was 200 mg L-1. Nitrates 72-79 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 29965484-10 2018 The Pseudomonas and Thermomonas emerged when the nitrate concentration increased to 500 mg L-1, and the rate of methane conversion was increased by 34.7%. Nitrates 49-56 immunoglobulin kappa variable 1-16 Homo sapiens 91-94 29518046-8 2018 Co-expression-network analysis of TFs with closely related profiles to known Nitrate-responsive genes identified GLK5, GLK8 and NLP15 as candidate regulators of genes repressed under low Nitrogen conditions, while bZIP108 might play a role in gene activation. Nitrates 77-84 uncharacterized LOC100191786 Zea mays 214-221 29443517-4 2018 Addition of nitrate with the Lewis acid Sc(OTf)3 (OTf = trifluoromethanesulfonate) to 2 results in an immediate and clean conversion of 2 to MoVI(O)2(SN)2 (1). Nitrates 12-19 POU class 5 homeobox 1 Homo sapiens 40-48 29513738-1 2018 Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter. Nitrates 171-179 hemoglobin subunit gamma 2 Homo sapiens 127-140 29513738-1 2018 Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter. Nitrates 171-179 hemoglobin subunit gamma 2 Homo sapiens 142-147 29553034-1 2018 Nitrate (NO3 -) is an ergogenic nutritional supplement that is widely used to improve physical performance. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 29360963-3 2018 Nitrite initially accumulated in all three soils; its subsequent decline or slowing of the accumulation of the NO2- pool by 24 h was accompanied by an increase in the size of the nitrate (NO3-) pool, indicating a change in NO2- oxidation kinetics. Nitrates 179-186 NBL1, DAN family BMP antagonist Homo sapiens 188-191 29306125-6 2018 The increased NO3--N/SCN--N ratio in the treated wastewater resulted in the decreased removal efficiency of nitrate, and the increased nitrate-to-nitrite transformation ratio and the ratio of NO2--N to NH4+-N. Nitrates 108-115 NBL1, DAN family BMP antagonist Homo sapiens 14-17 29306125-6 2018 The increased NO3--N/SCN--N ratio in the treated wastewater resulted in the decreased removal efficiency of nitrate, and the increased nitrate-to-nitrite transformation ratio and the ratio of NO2--N to NH4+-N. Nitrates 135-142 NBL1, DAN family BMP antagonist Homo sapiens 14-17 29348067-3 2018 NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX). Nitrates 37-44 peroxidase Solanum lycopersicum 240-243 29348067-3 2018 NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX). Nitrates 37-44 catalase isozyme 1 Solanum lycopersicum 246-254 29348067-3 2018 NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX). Nitrates 37-44 catalase isozyme 1 Solanum lycopersicum 256-259 29348067-3 2018 NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX). Nitrates 37-44 cytosolic ascorbate peroxidase 2 Solanum lycopersicum 262-282 29348067-3 2018 NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX). Nitrates 37-44 cytosolic ascorbate peroxidase 2 Solanum lycopersicum 284-287 29492096-1 2018 Background: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO3-) and nitrite (NO2-) and cardiovascular events, we assessed possible effects of dietary NO3- and NO2-, in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 105-108 29211505-4 2018 Dietary nitrate (NO3-) supplementation has been shown to lower the O2 consumption in various conditions. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 29432741-9 2018 Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis. Nitrates 115-122 DNA nucleotidylexotransferase Rattus norvegicus 0-37 29248688-6 2018 Under optimum conditions, the limits of detection in the original solutions were 0.49 mug L-1 and 0.40 mug L-1 for nitrate and nitrite, respectively. Nitrates 115-122 immunoglobulin kappa variable 1-16 Homo sapiens 90-93 29248688-6 2018 Under optimum conditions, the limits of detection in the original solutions were 0.49 mug L-1 and 0.40 mug L-1 for nitrate and nitrite, respectively. Nitrates 115-122 immunoglobulin kappa variable 1-16 Homo sapiens 107-110 29432741-9 2018 Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis. Nitrates 115-122 caspase 3 Rattus norvegicus 73-82 29432741-9 2018 Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis. Nitrates 115-122 superoxide dismutase 1 Rattus norvegicus 193-219 29432741-9 2018 Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis. Nitrates 115-122 superoxide dismutase 1 Rattus norvegicus 221-230 29432741-10 2018 Our findings indicate that nitrate could improve functional activity of the salivary glands in OVX rats by suppressing apoptosis and upregulating Cu-Zn SOD expression, suggesting that dietary nitrate may potentially prevent hyposalivation in menopausal women. Nitrates 27-34 superoxide dismutase 1 Rattus norvegicus 146-155 29432741-10 2018 Our findings indicate that nitrate could improve functional activity of the salivary glands in OVX rats by suppressing apoptosis and upregulating Cu-Zn SOD expression, suggesting that dietary nitrate may potentially prevent hyposalivation in menopausal women. Nitrates 192-199 superoxide dismutase 1 Rattus norvegicus 146-155 28992502-9 2018 Nitrate concentrations are generally low in the pristine headwaters (<3mgL-1) and increase downstream (15 to 16mgL-1) due to the contribution of agricultural and wastewater sources. Nitrates 0-7 LLGL scribble cell polarity complex component 1 Homo sapiens 74-79 28992502-9 2018 Nitrate concentrations are generally low in the pristine headwaters (<3mgL-1) and increase downstream (15 to 16mgL-1) due to the contribution of agricultural and wastewater sources. Nitrates 0-7 LLGL scribble cell polarity complex component 1 Homo sapiens 114-119 29159716-8 2018 MERA (100 mug/ml) inhibited total COX and 5-LOX activity at 50.53 and 62.03%, respectively, besides significantly (p < 0.05) diminished nitrate and ROS generation, when compared with LPS control. Nitrates 139-146 Era (G-protein)-like 1 (E. coli) Mus musculus 0-4 29964852-6 2018 The concentrations of effluent nitrate were lower than 0.5 mg L-1, and the nitrite accumulation rates were higher than 99%. Nitrates 31-38 immunoglobulin kappa variable 1-16 Homo sapiens 62-65 29876433-3 2018 The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively. Nitrates 85-92 latexin Homo sapiens 133-136 29876433-3 2018 The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively. Nitrates 85-92 latexin Homo sapiens 144-147 29876433-3 2018 The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively. Nitrates 85-92 PWWP domain containing 3A, DNA repair factor Homo sapiens 194-204 29876433-3 2018 The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively. Nitrates 85-92 latexin Homo sapiens 144-147 28916479-2 2018 Dietary nitrate (NO3-), a source of nitric oxide (NO), has improved these measures in some studies of other populations. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 28562133-1 2018 Dietary nitrate (NO3-) supplementation has been associated with improved vascular and metabolic health. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 29450536-8 2018 Nitrate/nitrite levels in HLE cells showed a significant increase with 2% Cu-Ch treatment compared to CS. Nitrates 0-7 elastase, neutrophil expressed Homo sapiens 26-29 29362099-1 2018 Nitrate reductase (NR) mainly reduces nitrate to nitrite. Nitrates 38-45 nitrate reductase [NADH]-like Cucumis sativus 0-17 29362099-1 2018 Nitrate reductase (NR) mainly reduces nitrate to nitrite. Nitrates 38-45 nitrate reductase [NADH]-like Cucumis sativus 19-21 29362099-12 2018 Moreover, the increase of nitrite tissue level in short-term stressed roots and the nitrite/nitrate ratio, with a simultaneous decrease of nitrite reductase (NiR) activity, in both short- and long-term stressed roots, could promote the production of NO by NR in roots under salt stress. Nitrates 92-99 nitrate reductase [NADH]-like Cucumis sativus 256-258 29364528-7 2018 Ectopic expression of ZmNLP3.1 restored the N-deficient phenotypes of nlp7-1 under nitrate-replete conditions in terms of shoot biomass, root morphology and nitrate assimilation. Nitrates 83-90 NIN like protein 7 Arabidopsis thaliana 70-74 29364528-8 2018 Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling. Nitrates 17-24 nitrate transport 2 Zea mays 38-42 29364528-8 2018 Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling. Nitrates 17-24 NIN like protein 7 Arabidopsis thaliana 112-116 29364528-8 2018 Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling. Nitrates 187-194 NIN like protein 7 Arabidopsis thaliana 112-116 29367694-0 2018 The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium. Nitrates 36-43 NIN like protein 7 Arabidopsis thaliana 16-20 28843981-2 2018 With nitrate (NO3-) being the main form of N available to cereal crops there has been a significant global research effort to understand plant NO3- uptake. Nitrates 5-12 NBL1, DAN family BMP antagonist Homo sapiens 14-17 29367694-0 2018 The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium. Nitrates 36-43 nitrate transporter 1.1 Arabidopsis thaliana 58-62 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 84-91 nitrate transporter 1.1 Arabidopsis thaliana 22-28 29367694-3 2018 In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7). Nitrates 70-77 nitrate transporter 1.1 Arabidopsis thaliana 46-52 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 84-91 NIN like protein 7 Arabidopsis thaliana 32-36 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 119-126 nitrate transporter 1.1 Arabidopsis thaliana 22-28 29367694-3 2018 In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7). Nitrates 70-77 nitrate transporter 1.1 Arabidopsis thaliana 116-120 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 119-126 NIN like protein 7 Arabidopsis thaliana 32-36 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 119-126 nitrate transporter 1.1 Arabidopsis thaliana 22-28 29367694-5 2018 Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines. Nitrates 119-126 NIN like protein 7 Arabidopsis thaliana 32-36 29367694-8 2018 Thus, NLP7 acts as an important factor in nitrate signaling via regulating NRT1.1 under NH4+ conditions. Nitrates 42-49 NIN like protein 7 Arabidopsis thaliana 6-10 29367694-8 2018 Thus, NLP7 acts as an important factor in nitrate signaling via regulating NRT1.1 under NH4+ conditions. Nitrates 42-49 nitrate transporter 1.1 Arabidopsis thaliana 75-79 29367694-3 2018 In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7). Nitrates 70-77 nitrate transporter 1.1 Arabidopsis thaliana 125-131 29367694-3 2018 In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7). Nitrates 70-77 NIN like protein 7 Arabidopsis thaliana 150-168 29367694-3 2018 In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7). Nitrates 70-77 NIN like protein 7 Arabidopsis thaliana 170-174 29367694-4 2018 Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1. Nitrates 78-85 NIN like protein 7 Arabidopsis thaliana 45-49 29367694-4 2018 Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1. Nitrates 78-85 nitrate transporter 1.1 Arabidopsis thaliana 68-74 29367694-4 2018 Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1. Nitrates 161-168 NIN like protein 7 Arabidopsis thaliana 45-49 28886566-6 2018 Removal of 60mgL-1 NH4+-N was associated only with smaller amounts of nitrite build-up (~5mgL-1 NO2--N) and negligible nitrate concentrations. Nitrates 119-126 LLGL scribble cell polarity complex component 1 Homo sapiens 13-18 29309650-0 2018 SMZ/SNZ and gibberellin signaling are required for nitrate-elicited delay of flowering time in Arabidopsis thaliana. Nitrates 51-58 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 0-7 29309650-5 2018 We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate. Nitrates 211-218 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 110-121 29309650-5 2018 We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate. Nitrates 211-218 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 123-126 29309650-5 2018 We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate. Nitrates 211-218 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 132-146 29309650-5 2018 We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate. Nitrates 211-218 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 148-151 29309650-6 2018 Our results support a model whereby nitrate activates SMZ and SNZ via the gibberellin pathway to repress flowering time in Arabidopsis thaliana. Nitrates 36-43 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 54-57 29309650-6 2018 Our results support a model whereby nitrate activates SMZ and SNZ via the gibberellin pathway to repress flowering time in Arabidopsis thaliana. Nitrates 36-43 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 62-65 29343715-5 2018 In this layer, the nitrate leaching values for T1 (13.76 kg ha-2) and T2 (13.74 kg ha-2) were both significantly lower than those of the control (15.76 kg ha-2) (P < 0.05); the soil nitrate leaching losses decreased by 12.71% and 12.84% for those two treatments, respectively. Nitrates 19-26 keratin 32 Homo sapiens 60-64 29324707-1 2018 Controlled release urea (CRU) is considered to enhance crop yields while alleviating negative environmental problems caused by the hazardous gas emissions that are associated with high concentrations of ammonium (NH4+) and nitrate (NO3-) in black soils. Nitrates 223-230 NBL1, DAN family BMP antagonist Homo sapiens 232-235 29070503-8 2018 Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = -0.51, r = -0.48, r = -0.42, respectively, P < 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P < 0.05). Nitrates 248-255 adiponectin, C1Q and collagen domain containing Homo sapiens 119-130 29526907-3 2018 The developed on-line PIEC ion stacking-ion chromatography method was validated by recovery experiments for the determination of nitrate in tap water in terms of both accuracy and precision, and the results showed the reliability of the method. Nitrates 129-136 nuclear RNA export factor 1 Homo sapiens 140-143 29778214-3 2018 Recent attempts to characterize bacterial NOS (bNOS) have resulted in the discovery of structural features that may allow it to function as a NO dioxygenase and produce nitrate in addition to NO. Nitrates 169-176 nitric oxide synthase 1 Homo sapiens 47-51 29778214-4 2018 Consistent with this characterization, investigations into the biological function of bNOS have also emphasized a role for NOS-dependent nitrate and nitrite production in aerobic and microaerobic respiration. Nitrates 137-144 nitric oxide synthase 1 Homo sapiens 86-90 29166553-3 2018 Topical nitrates (TN) heal CAF effectively but recurrences are common. Nitrates 8-16 lysine acetyltransferase 2B Homo sapiens 27-30 29985754-4 2018 Nitrate levels were systematically high (> 50 mg L-1 in a significant number of samples) and mean levels of trace elements were higher than the established values of Canadian Environmental Quality Guidelines for aquatic life protection for Al, Cu, Se, Ag, Cd and Pb in Douro and Ave, and also Zn in Ave. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 52-55 28942280-9 2018 Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin. Nitrates 19-26 hemoglobin subunit gamma 2 Homo sapiens 102-115 29368802-2 2018 We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 36-39 29473797-5 2018 Among various antioxidants, Vit E reacted more effectively with many nitrosating agents such as nitrate and nitrite found in cosmetic products. Nitrates 96-103 vitrin Homo sapiens 28-31 28988245-1 2018 BACKGROUND/AIMS: 2-aminoethyl nitrate (CLC-1011) is a member of the class of organic nitrates that cause vasodilation by the generation of nitric oxide ( NO). Nitrates 85-93 Charcot-Leyden crystal galectin Homo sapiens 39-42 29380952-1 2018 Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 28826121-5 2018 The major elements were all within the World Health Organization (WHO) guidelines for drinking water quality, except for nitrates in some wells, which was found at a concentration >50mg NO3-/L. Nitrates 121-129 NBL1, DAN family BMP antagonist Homo sapiens 189-192 29304531-9 2018 Following nitrate supplementation, plasma RSNO was elevated (4.7 +- 0.8 vs 0.2 +- 0.5 nM) and thrombin-receptor mediated platelet aggregation was reduced (-19.9 +- 6.0 vs 4.0 +- 6.4 U) only in the clopidogrel group compared with placebo. Nitrates 10-17 coagulation factor II, thrombin Homo sapiens 94-102 29307111-6 2018 Daily nitrate intake (0.5 mmol L-1) restored nitrate levels, decreased ALT and AST levels, and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose (D-gal)-induced ageing mice (n=10) and in natural aged mice (n=10). Nitrates 6-13 glutamic pyruvic transaminase, soluble Mus musculus 71-74 29307111-6 2018 Daily nitrate intake (0.5 mmol L-1) restored nitrate levels, decreased ALT and AST levels, and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose (D-gal)-induced ageing mice (n=10) and in natural aged mice (n=10). Nitrates 6-13 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 79-82 29377837-1 2018 In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3-) from water, and the reaction mechanism for this is discussed. Nitrates 155-162 NBL1, DAN family BMP antagonist Homo sapiens 164-167 30099420-7 2018 RESULTS: Results: When studying the content of methemoglobin among adult population in village areas, where well water with a high concentration of nitrates is consumed and in the city where centralized water supply is used, it was observed that rural people have a higher level of methemoglobin. Nitrates 148-156 hemoglobin subunit gamma 2 Homo sapiens 47-60 28693108-0 2017 Nitrate release from waste rock dumps in the Elk Valley, British Columbia, Canada. Nitrates 0-7 potassium voltage-gated channel subfamily H member 8 Homo sapiens 45-48 28763658-8 2017 Isotopes of delta15N-NO3- and delta18O-NO3- verified that nitrate in groundwater of the NV (with delta15N ranging from 1.7% to 4.7%) was sourced from soil and precipitation. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 21-24 28763658-8 2017 Isotopes of delta15N-NO3- and delta18O-NO3- verified that nitrate in groundwater of the NV (with delta15N ranging from 1.7% to 4.7%) was sourced from soil and precipitation. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 39-42 28793404-4 2017 The simulated wastewater included sulphate (27.2mgL-1), nitrate (7.6mgL-1), ammonium (9.1mgL-1), phosphate (7.4mgL-1), and chloride (47.2mgL-1). Nitrates 56-63 LLGL scribble cell polarity complex component 1 Homo sapiens 68-73 28793404-4 2017 The simulated wastewater included sulphate (27.2mgL-1), nitrate (7.6mgL-1), ammonium (9.1mgL-1), phosphate (7.4mgL-1), and chloride (47.2mgL-1). Nitrates 56-63 LLGL scribble cell polarity complex component 1 Homo sapiens 68-73 29187692-11 2017 T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria. Nitrates 83-90 NIN like protein 7 Arabidopsis thaliana 123-127 29187692-11 2017 T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria. Nitrates 83-90 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 132-137 29187692-11 2017 T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria. Nitrates 154-161 NIN like protein 7 Arabidopsis thaliana 123-127 29187692-11 2017 T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria. Nitrates 154-161 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 132-137 28693108-1 2017 The origin, distribution and leaching of nitrate (NO3-) from coal waste rock dumps in the Elk Valley, British Columbia, Canada were defined using chemical and NO3- isotope analyses (delta15N- and delta18O-NO3-) of solids samples of pre- and post-blast waste rock and from thick (up to 180m) unsaturated waste rock dump profiles constructed between 1982 and 2012 as well as water samples collected from a rock drain located at the base of one dump and effluent from humidity cell (HC) and leach pad (LP) tests on waste rock. Nitrates 41-48 NBL1, DAN family BMP antagonist Homo sapiens 50-53 29629873-8 2017 ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling. Nitrates 188-195 diazepam binding inhibitor-like 5 Rattus norvegicus 0-3 29629873-8 2017 ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling. Nitrates 188-195 vascular endothelial growth factor A Rattus norvegicus 4-8 28871315-2 2017 Multiday incubations of effluent collected from the Branford and New Haven, Connecticut, waste water treatment plants (WWTP) revealed low but steady conversion of organic nitrogen to nitrate (NO3-). Nitrates 183-190 NBL1, DAN family BMP antagonist Homo sapiens 192-195 28661182-5 2017 OBJECTIVES: We implemented Bayesian-distributed lag interaction models to identify sensitive prenatal windows for the influence of nitrate (NO3-) on child asthma, accounting for effect modification by sex and stress. Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 28898831-4 2017 In addition, higher NO3- removal by microalgae assimilation led to better water quality in AA, which made up for the deficiencies of poor aquaponic management of nitrate. Nitrates 162-169 NBL1, DAN family BMP antagonist Homo sapiens 20-23 28850721-0 2017 The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1. Nitrates 57-64 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 16-22 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 28-35 NIN like protein 7 Arabidopsis thaliana 282-286 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 302-309 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 172-178 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 302-309 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 227-233 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 302-309 nitrate transporter 1.1 Arabidopsis thaliana 254-260 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 302-309 NIN like protein 7 Arabidopsis thaliana 282-286 28850721-7 2017 Nitrate uptake was decreased in the mutant along with reduced expression of the nitrate transporter/sensor gene NRT1.1, while nitrate reduction and amino acid content were enhanced in roots along with increased expression of several nitrate assimilatory genes. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 112-118 28850721-7 2017 Nitrate uptake was decreased in the mutant along with reduced expression of the nitrate transporter/sensor gene NRT1.1, while nitrate reduction and amino acid content were enhanced in roots along with increased expression of several nitrate assimilatory genes. Nitrates 80-87 nitrate transporter 1.1 Arabidopsis thaliana 112-118 28850721-8 2017 These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network. Nitrates 77-84 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 59-65 28850721-0 2017 The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1. Nitrates 57-64 nitrate transporter 1.1 Arabidopsis thaliana 118-124 28850721-8 2017 These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network. Nitrates 77-84 nitrate transporter 1.1 Arabidopsis thaliana 117-121 28850721-8 2017 These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network. Nitrates 178-185 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 59-65 28850721-3 2017 We report here the identification of a nitrate regulatory mutant whose mutation mapped to the Cleavage and Polyadenylation Specificity Factor 30 gene (CPSF30-L). Nitrates 39-46 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 151-157 28850721-8 2017 These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network. Nitrates 178-185 nitrate transporter 1.1 Arabidopsis thaliana 117-121 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 28-35 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 172-178 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 28-35 cleavage and polyadenylation specificity factor 30 Arabidopsis thaliana 227-233 28850721-4 2017 In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate. Nitrates 28-35 nitrate transporter 1.1 Arabidopsis thaliana 254-260 28570975-12 2017 Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources. Nitrates 8-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 49-52 28570975-12 2017 Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources. Nitrates 8-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 78-81 28165641-1 2017 Nitrate (NO3-) supplementation resulting in higher plasma nitrite (NO2-) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance-trained individuals. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 28570975-12 2017 Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources. Nitrates 8-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 78-81 28570975-12 2017 Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources. Nitrates 8-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 78-81 29064247-5 2017 Upon amendment with phosphate, the consortium completely degraded up to ~10 mM SCN- to ammonium and sulfate, with some evidence of nitrification of the ammonium to nitrate. Nitrates 164-171 sorcin Homo sapiens 79-82 29185502-1 2017 Nitrogen (N) as a nutrient, in the form of nitrate (NO3-), is essential for plant growth. Nitrates 43-50 NBL1, DAN family BMP antagonist Homo sapiens 52-55 29035054-0 2017 Quantum Yields of Nitrite (NO2-) from the Photolysis of Nitrate (NO3-) in Ice at 313 nm. Nitrates 56-63 NBL1, DAN family BMP antagonist Homo sapiens 65-68 28954516-4 2017 Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier. Nitrates 0-7 latexin Homo sapiens 37-40 29143202-0 2017 Tobacco plants expressing the maize nitrate transporter ZmNrt2.1 exhibit altered responses of growth and gene expression to nitrate and calcium. Nitrates 36-43 nitrate transport 2 Zea mays 56-64 29143202-3 2017 In this report, we introduced into tobacco (Nicotiana tabacum) the constitutively expressed maize high-affinity transporter ZmNrt2.1 gene that would bypass the tight control for the endogenous nitrate-responsive genes. Nitrates 193-200 nitrate transport 2 Zea mays 124-132 29143202-5 2017 RESULTS: We found that the ZmNrt2.1-expressing plants had better root growth than the wild type plants when Ca2+ was deficient regardless of the nitrate levels. Nitrates 145-152 nitrate transport 2 Zea mays 27-35 28954516-4 2017 Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier. Nitrates 0-7 latexin Homo sapiens 48-51 28954516-4 2017 Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier. Nitrates 0-7 latexin Homo sapiens 48-51 28954516-4 2017 Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier. Nitrates 0-7 latexin Homo sapiens 48-51 28387958-5 2017 The method was also found to be suitable for the preconcentration of an anion (nitrate at 100 muM) in presence of a second anion at a very high concentration (50 mM formate). Nitrates 79-86 latexin Homo sapiens 94-97 28387958-6 2017 The detection limits for the four anions chloride, nitrate, perchlorate, and formate could be lowered from 4, 4.3, 4.2, and 7.2 muM obtained without trapping respectively to 127, 142, 139, and 451 nM with trapping. Nitrates 51-58 latexin Homo sapiens 128-131 28941934-8 2017 Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P < 0.001). Nitrates 57-64 immunoglobulin kappa variable 1-16 Homo sapiens 131-134 28941934-8 2017 Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P < 0.001). Nitrates 57-64 immunoglobulin kappa variable 1-16 Homo sapiens 150-153 28941934-8 2017 Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P < 0.001). Nitrates 57-64 immunoglobulin kappa variable 1-16 Homo sapiens 150-153 28750288-1 2017 Excessive nitrate (NO3-) concentration in groundwater raises health and environmental issues that must be addressed by all European Union (EU) member states under the Nitrates Directive and the Water Framework Directive. Nitrates 10-17 NBL1, DAN family BMP antagonist Homo sapiens 19-22 28067100-10 2017 In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice. Nitrates 80-87 apolipoprotein E Mus musculus 113-117 28067100-10 2017 In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice. Nitrates 80-87 low density lipoprotein receptor Mus musculus 118-122 28482109-4 2017 All investigated tree species showed highest uptake rates for NH4+ (ammonium), followed by glycine and NO3- (nitrate). Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 103-106 28750288-1 2017 Excessive nitrate (NO3-) concentration in groundwater raises health and environmental issues that must be addressed by all European Union (EU) member states under the Nitrates Directive and the Water Framework Directive. Nitrates 167-175 NBL1, DAN family BMP antagonist Homo sapiens 19-22 29049377-9 2017 Thus, our data support the idea that in S-deprived cells THB1 plays a dual role in NO detoxification and in coordinating sulfate limitation with nitrate assimilation. Nitrates 145-152 uncharacterized protein Chlamydomonas reinhardtii 57-61 29077028-1 2017 Supplementation with nitrate (NO3-)-rich beetroot juice has been shown to improve exercise performance and cardiovascular (CV) responses, due to an increased nitric oxide (NO) availability. Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 30-33 29051766-0 2017 Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Nitrates 77-84 Protein NLP3 Zea mays 39-45 29051766-0 2017 Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Nitrates 77-84 NIN like protein 7 Arabidopsis thaliana 103-107 29051766-0 2017 Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Nitrates 121-128 NIN like protein 7 Arabidopsis thaliana 103-107 29051766-0 2017 Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation. Nitrates 121-128 Protein NLP3 Zea mays 39-45 29051766-4 2017 When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism. Nitrates 61-68 Protein NLP3 Zea mays 16-22 29051766-4 2017 When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism. Nitrates 61-68 NIN like protein 7 Arabidopsis thaliana 92-96 28876920-2 2017 Uranium(IV) is sparingly soluble, but may be mobilized upon exposure to nitrate (NO3-) and oxygen (O2), which become elevated in groundwater due to seasonal fluctuations in the water table. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 29051766-4 2017 When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism. Nitrates 100-107 Protein NLP3 Zea mays 16-22 29051766-4 2017 When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism. Nitrates 100-107 Protein NLP3 Zea mays 16-22 29051766-4 2017 When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism. Nitrates 100-107 Protein NLP3 Zea mays 16-22 29051766-5 2017 ZmNLP6 and ZmNLP8 are localized in the nucleus and can bind candidate nitrate-responsive cis-elements in vitro. Nitrates 70-77 Protein NLP3 Zea mays 11-17 29051766-7 2017 Thus, ZmNLP6 and ZmNLP8 regulate nitrate signaling in transgenic Arabidopsis plants and may be potential candidates for improving nitrogen use efficiency of maize. Nitrates 33-40 Protein NLP3 Zea mays 17-23 28689147-1 2017 Quantitative identification of nitrate (NO3--N) sources is critical to the control of nonpoint source nitrogen pollution in an agricultural watershed. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 40-43 28625350-4 2017 Inorganic pollutants viz., nitrates (28%; 8%), sulphates (25%; 9%) and phosphates (20%; 7%) removal was higher in ME-BET in comparison with SE-BET and this was also supported with bioelectrogenic activity (584; 160mW/m3). Nitrates 27-35 delta/notch like EGF repeat containing Homo sapiens 117-120 28722226-11 2017 SLAC1 and SLAH3 mediate chloride and nitrate transport in guard cells, while SLAH1, SLAH2 and SLAH3 are engaged in root nitrate and chloride acquisition, and anion translocation to the shoot. Nitrates 37-44 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 0-5 26524711-2 2017 Here, we review pivotal interactions with respect to root acquisition, storage, translocation and metabolism, between the K+ ion and the two major N sources, ammonium (NH4+ ) and nitrate (NO3- ). Nitrates 179-186 NBL1, DAN family BMP antagonist Homo sapiens 188-191 28887406-0 2017 Maize NPF6 Proteins Are Homologs of Arabidopsis CHL1 That Are Selective for Both Nitrate and Chloride. Nitrates 81-88 nitrate transporter 1.1 Arabidopsis thaliana 48-52 28771873-0 2017 Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana. Nitrates 0-7 bZIP transcription factor family protein Arabidopsis thaliana 54-58 28771873-0 2017 Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana. Nitrates 0-7 TGACG motif-binding factor 4 Arabidopsis thaliana 59-63 28578274-0 2017 Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation. Nitrates 50-57 xanthine dehydrogenase Rattus norvegicus 72-95 28771873-0 2017 Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana. Nitrates 0-7 Homeodomain-like superfamily protein Arabidopsis thaliana 68-71 28771873-6 2017 Nitrate reductase-null mutants exhibited nitrate-dependent root hair phenotypes comparable with wild-type plants, indicating that nitrate is the signal that leads to increased formation of root hairs. Nitrates 41-48 nitrate reductase 1 Arabidopsis thaliana 0-17 28771873-6 2017 Nitrate reductase-null mutants exhibited nitrate-dependent root hair phenotypes comparable with wild-type plants, indicating that nitrate is the signal that leads to increased formation of root hairs. Nitrates 130-137 nitrate reductase 1 Arabidopsis thaliana 0-17 28771873-8 2017 Phenotypic analyses of these mutants showed that CPC is essential for nitrate-induced responses of root hair development. Nitrates 70-77 Homeodomain-like superfamily protein Arabidopsis thaliana 49-52 28771873-10 2017 Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana. Nitrates 35-42 bZIP transcription factor family protein Arabidopsis thaliana 57-61 28771873-10 2017 Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana. Nitrates 35-42 TGACG motif-binding factor 4 Arabidopsis thaliana 62-66 28771873-10 2017 Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana. Nitrates 35-42 Homeodomain-like superfamily protein Arabidopsis thaliana 90-93 28653185-1 2017 MAIN CONCLUSION: The nitrate transporters, belonging to NPF and NRT2 families, play critical roles in nitrate signaling, root growth and nodule development in legumes. Nitrates 21-28 nrt2 Lotus japonicus 64-68 28921396-3 2017 Nitrate concentration was highly variable from 0.25 to 22 mg L-1 in surface water and from 0.5 to 100 mg L-1 in groundwater. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 61-64 28623824-8 2017 Mechanistically, nitrate treatment reduced renal superoxide generation, pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12 p70) and macrophage infiltration in the kidney. Nitrates 17-24 interleukin 1 beta Mus musculus 100-108 28623824-8 2017 Mechanistically, nitrate treatment reduced renal superoxide generation, pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12 p70) and macrophage infiltration in the kidney. Nitrates 17-24 interleukin 6 Mus musculus 110-114 28623824-10 2017 In another cohort of mice, two weeks of nitrate supplementation lowered superoxide generation and IL-6 expression in bone marrow-derived macrophages. Nitrates 40-47 interleukin 6 Mus musculus 98-102 28921396-3 2017 Nitrate concentration was highly variable from 0.25 to 22 mg L-1 in surface water and from 0.5 to 100 mg L-1 in groundwater. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 28817281-5 2017 Metrical fits of Th coordination as a function of nitrate concentration are used to calculate Th-NO3 stability constants, information important to a molecular-scale description of reaction energetics. Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 97-100 28716476-1 2017 In the present study, we investigated the influence of phenanthrene (PHE), a three-ring polycyclic aromatic hydrocarbon (PAH) compound, on nitrate (NO3-) reduction processes in mangrove sediments using microcosms. Nitrates 139-146 NBL1, DAN family BMP antagonist Homo sapiens 148-151 29026794-1 2017 BACKGROUND: Nitrite (NO2-) and nitrate (NO3-) contaminations of groundwater are considered as one of the major health challenges in recent decades. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 40-43 28928722-6 2017 At high Lac/N ratio (2.97 mol/mol) both fermentative and respiratory nitrate reduction to ammonium occurred, coupled to partial oxidation of lactate to acetate, and to acetate oxidation respectively. Nitrates 69-76 lactase Homo sapiens 8-11 28928722-8 2017 At a decreased Lac/N ratio (1.15 mol/mol), the molar percentage of nitrate reduced to ammonium decreased to 58%, even though lactate was supplied in adequate amounts for full ammonification and nitrate remained the growth limiting compound. Nitrates 67-74 lactase Homo sapiens 15-18 28928722-8 2017 At a decreased Lac/N ratio (1.15 mol/mol), the molar percentage of nitrate reduced to ammonium decreased to 58%, even though lactate was supplied in adequate amounts for full ammonification and nitrate remained the growth limiting compound. Nitrates 194-201 lactase Homo sapiens 15-18 28739973-1 2017 Dietary NO3- (nitrate) and NO2- (nitrite) support NO (nitric oxide) generation and downstream vascular signaling responses. Nitrates 14-21 NBL1, DAN family BMP antagonist Homo sapiens 8-11 28798125-3 2017 Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the gene encoding inducible nitric oxide synthase, was elevated in the absence of PPAR-gamma signaling. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 79-83 28710281-1 2017 Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure. Nitrates 0-7 NBL1, DAN family BMP antagonist Mus musculus 9-12 28710281-1 2017 Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure. Nitrates 0-7 NBL1, DAN family BMP antagonist Mus musculus 106-109 28285190-0 2017 Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite. Nitrates 0-7 xanthine dehydrogenase Rattus norvegicus 18-41 28671819-4 2017 The reduced, ferrous cytoglobin can bind oxygen and will react with NO in a dioxygenation reaction to form nitrate, which dampens NO signaling. Nitrates 107-114 cytoglobin Homo sapiens 21-31 28285190-3 2017 Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. Nitrates 79-86 xanthine dehydrogenase Rattus norvegicus 10-33 28285190-3 2017 Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. Nitrates 79-86 xanthine dehydrogenase Rattus norvegicus 35-38 28285190-4 2017 However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite. Nitrates 39-46 xanthine dehydrogenase Rattus norvegicus 58-61 28285190-5 2017 We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation. Nitrates 21-28 xanthine dehydrogenase Rattus norvegicus 190-193 28285190-5 2017 We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation. Nitrates 21-28 xanthine dehydrogenase Rattus norvegicus 211-214 28285190-12 2017 Next, we used chemiluminescence-based NO detection to examine whether nitrate attenuates XOR-mediated nitrite reductase activity. Nitrates 70-77 xanthine dehydrogenase Rattus norvegicus 89-92 28429398-6 2017 The bacterial denitrifer method was used to convert 20 muM of collected NO2- or nitrate (NO3- ) into N2 O and was carried out on an Isoprime continuous flow isotope ratio mass spectrometer. Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 89-92 28285190-14 2017 Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite. Nitrates 32-39 xanthine dehydrogenase Rattus norvegicus 49-52 28285190-14 2017 Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite. Nitrates 125-132 xanthine dehydrogenase Rattus norvegicus 49-52 28262362-4 2017 The reduction of Cr(VI) by NO2- was limited in water, whereas it was significant in ice with the simultaneous oxidation of NO2- to nitrate (NO3-). Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 29964603-2 2017 The results showed that organics was the main component of PM1, and the proportion of nitrate was higher than that of sulfate in autumn and winter. Nitrates 86-93 transmembrane protein 11 Homo sapiens 59-62 28717175-7 2017 Interestingly, MARC1, which encodes an enzyme discovered to catalyze reduction of nitrate to NO, was identified as a novel VEGFR-2 regulated gene. Nitrates 82-89 mitochondrial amidoxime-reducing component 1 Oryctolagus cuniculus 15-20 29964603-7 2017 Nitrate was the major contributor of NR-PM1 during the polluted period, while organics was significantly higher than that during clean period. Nitrates 0-7 transmembrane protein 11 Homo sapiens 40-43 28536248-5 2017 We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification. Nitrates 283-290 chloride channel A Arabidopsis thaliana 63-81 28536248-5 2017 We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification. Nitrates 283-290 chloride channel A Arabidopsis thaliana 83-88 28536248-5 2017 We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification. Nitrates 283-290 chloride channel A Arabidopsis thaliana 227-232 28656558-8 2017 Organic carbon increased the sensor nitrate plus nitrite results, not only in waters with high organic carbon concentrations, but also at the lower concentrations (< 10 mg C L-1) typical of boreal stream, river, and lake waters. Nitrates 36-43 adhesion G protein-coupled receptor L1 Homo sapiens 175-180 28419436-4 2017 We found that net nitrate (NO3- ) bioavailability is positively related to MAT (r2 = 0.79, P = 0.0033), and AOA DNA abundance is positively related to both NO3- availability (r2 = 0.34, P = 0.0071) and MAT (r2 = 0.34, P < 0.001). Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 28319596-3 2017 The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for more than 1 week has beneficial effects on SBP and DBP. Nitrates 107-114 selenium binding protein 1 Homo sapiens 178-181 29657554-6 2017 Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N). Nitrates 55-62 CD59 molecule (CD59 blood group) Homo sapiens 36-41 29657554-6 2017 Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N). Nitrates 92-99 CD59 molecule (CD59 blood group) Homo sapiens 36-41 29657554-6 2017 Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N). Nitrates 92-99 CD59 molecule (CD59 blood group) Homo sapiens 36-41 28647259-6 2017 The reduction rate of SNA (sulfate, nitrate and ammonium) concentrations was significantly higher than that of PM2.5 in 2017, implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA. Nitrates 36-43 snail family transcriptional repressor 1 Homo sapiens 22-25 28319596-3 2017 The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for more than 1 week has beneficial effects on SBP and DBP. Nitrates 107-114 D-box binding PAR bZIP transcription factor Homo sapiens 186-189 28319596-11 2017 Overall, dietary nitrate was associated with a significant decline in SBP [-4.1 mmHg (95% confidence interval: -6.1, -2.2); P < 0.001] and DBP [-2.0 mmHg (95% confidence interval: -3.0, -0.9); P < 0.001]. Nitrates 17-24 selenium binding protein 1 Homo sapiens 70-73 28319596-11 2017 Overall, dietary nitrate was associated with a significant decline in SBP [-4.1 mmHg (95% confidence interval: -6.1, -2.2); P < 0.001] and DBP [-2.0 mmHg (95% confidence interval: -3.0, -0.9); P < 0.001]. Nitrates 17-24 D-box binding PAR bZIP transcription factor Homo sapiens 142-145 27987212-5 2017 Comparison of nitrate-grown wild-type with AOX knockdown and overexpression plants showed a negative correlation between AOX amount and NO amount following AA. Nitrates 14-21 ubiquinol oxidase 1, mitochondrial Nicotiana tabacum 43-46 27987212-5 2017 Comparison of nitrate-grown wild-type with AOX knockdown and overexpression plants showed a negative correlation between AOX amount and NO amount following AA. Nitrates 14-21 ubiquinol oxidase 1, mitochondrial Nicotiana tabacum 121-124 28680423-8 2017 Use of bioreactors to study the effect of nitrate injection on sulfate reduction showed that accumulation of nitrite inhibited SRB activity at 2.5 M but not at 0.5 M NaCl. Nitrates 42-49 chaperonin containing TCP1 subunit 4 Homo sapiens 127-130 28370621-5 2017 In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport. Nitrates 10-17 nitrate transporter 1.1 Arabidopsis thaliana 3-7 28370621-5 2017 In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport. Nitrates 10-17 nitrate transporter 1.1 Arabidopsis thaliana 105-109 28370621-5 2017 In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport. Nitrates 155-162 nitrate transporter 1.1 Arabidopsis thaliana 3-7 28370621-5 2017 In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport. Nitrates 155-162 nitrate transporter 1.1 Arabidopsis thaliana 105-109 28680423-10 2017 A diverse microbial community dominated by the SRB Desulfovibrio was observed at 0.5 M NaCl both in the presence and absence of nitrate. Nitrates 128-135 chaperonin containing TCP1 subunit 4 Homo sapiens 47-50 28487127-6 2017 Moreover, docking study of the synthesized compounds on EGFR (PDB code: 1M17) and cytotoxicity study indicated that N-1 phenyl para substitution, pyrazole C-3 alkyl substitution and tethering the nitrate moiety through butyl group had a significant impact on the activity. Nitrates 196-203 epidermal growth factor receptor Homo sapiens 56-60 28488152-7 2017 Furthermore, asthma ERVs was significantly associated with concentrations of nitrate (NO3-), with the RR for each 1 mug m-3 increase in NO3- concentrations being 1.004 (95% CI = 1.001-1.007) at lag 0 day. Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 86-89 28617311-1 2017 This study aimed to investigate whether the -1026(A>C)(rs2779249) and +2087(A>G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx). Nitrates 225-232 nitric oxide synthase 2 Homo sapiens 117-121 28488152-7 2017 Furthermore, asthma ERVs was significantly associated with concentrations of nitrate (NO3-), with the RR for each 1 mug m-3 increase in NO3- concentrations being 1.004 (95% CI = 1.001-1.007) at lag 0 day. Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 136-139 27997263-1 2017 We aimed to compare the effects of two different dosing durations of dietary nitrate (NO3-) supplementation on 1 and 4 km cycling time-trial performance in highly trained cyclists. Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 86-89 28328165-6 2017 Of the two chlorophytes, one grew significantly faster on nitrate (NO3- ), whereas the other grew significantly faster on NH4+ . Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 28489820-7 2017 Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment. Nitrates 64-71 calcium-dependent protein kinase 1 Arabidopsis thaliana 12-17 28237470-3 2017 Land use of the watershed is mainly agricultural leading to groundwater nitrate concentrations >50mgL-1 and a need for water treatment prior to utilization as drinking water. Nitrates 72-79 LLGL scribble cell polarity complex component 1 Homo sapiens 101-106 28489820-7 2017 Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment. Nitrates 64-71 calcium-dependent protein kinase 30 Arabidopsis thaliana 18-23 28489820-7 2017 Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment. Nitrates 64-71 calcium-dependent protein kinase 32 Arabidopsis thaliana 24-29 28489820-7 2017 Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment. Nitrates 64-71 NIN like protein 7 Arabidopsis thaliana 34-38 28426211-1 2017 A limited number of ground measurements of dry particulate nitrate deposition (NO3-) makes it difficult and challenging to fully know the status of the spatial and temporal variations of dry NO3- depositions over China. Nitrates 59-66 NBL1, DAN family BMP antagonist Homo sapiens 79-82 28152440-5 2017 Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring. Nitrates 133-140 NBL1, DAN family BMP antagonist Homo sapiens 75-78 28152440-5 2017 Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring. Nitrates 200-207 NBL1, DAN family BMP antagonist Homo sapiens 75-78 28152440-5 2017 Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring. Nitrates 200-207 NBL1, DAN family BMP antagonist Homo sapiens 75-78 28228237-1 2017 At the catchment scale, a complex mosaic of environmental, hydrogeological and physicochemical characteristics combine to regulate the distribution of groundwater and stream nitrate (NO3-). Nitrates 174-181 NBL1, DAN family BMP antagonist Homo sapiens 183-186 28187386-1 2017 A novel DEAMOX system was developed for nitrogen removal from domestic wastewater and nitrate (NO3--N) sewage in sequencing batch reactor (SBR). Nitrates 86-93 NBL1, DAN family BMP antagonist Homo sapiens 95-98 28425719-3 2017 Monodentate mononuclear (MM1) surface complexes are shown to lead to the most favorable thermodynamic adsorption for both bicarbonate and nitrate with -63.91 and -28.25 kJ/mol, respectively, under neutral conditions. Nitrates 138-145 prefoldin subunit 5 Homo sapiens 25-28 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrates 207-214 interleukin 1 beta Homo sapiens 12-16 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrates 207-214 interleukin 1 receptor antagonist Homo sapiens 86-110 28131792-10 2017 Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue. Nitrates 207-214 interleukin 1 receptor antagonist Homo sapiens 112-118 28201747-2 2017 Nitrate (NO3-) has a relevant role in plant-like organisms, first as a nitrogen source for growth and second as a signalling molecule. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 28201747-4 2017 Transporters provide a first step for influx/efflux, homeostasis, and sensing of nitrate; and NIT2 is the key transcription factor (RWP-RK) for mediating the nitrate-dependent activation of a number of genes. Nitrates 81-88 nitrilase family member 2 Homo sapiens 94-98 28201747-4 2017 Transporters provide a first step for influx/efflux, homeostasis, and sensing of nitrate; and NIT2 is the key transcription factor (RWP-RK) for mediating the nitrate-dependent activation of a number of genes. Nitrates 158-165 nitrilase family member 2 Homo sapiens 94-98 28073812-8 2017 Here, we show that PSPTO_3957 does not influence growth on rich media, motility or biofilm formation but is necessary for nitrate assimilation and full virulence in P. syringae. Nitrates 122-129 sulfurtransferase TusA family protein Pseudomonas syringae pv. tomato str. DC3000 19-29 28369507-4 2017 Recent evidence posits that in one nitrate signaling pathway, nitrate sensed by NRT1.1 activates a phospholipase C activity that is necessary for increased cytosolic calcium levels. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 80-84 28369507-4 2017 Recent evidence posits that in one nitrate signaling pathway, nitrate sensed by NRT1.1 activates a phospholipase C activity that is necessary for increased cytosolic calcium levels. Nitrates 62-69 nitrate transporter 1.1 Arabidopsis thaliana 80-84 28442008-0 2017 Biotransformation of RDX and HMX by Anaerobic Granular Sludge with Enriched Sulfate and Nitrate. Nitrates 88-95 radixin Homo sapiens 21-24 28442008-2 2017 The present study investigated the biotransformation of RDX and HMX by anaerobic granular sludge under sulfate- and nitrate-enriched conditions. Nitrates 116-123 radixin Homo sapiens 56-59 28442008-3 2017 The results showed that RDX and HMX could be transformed by anaerobic granular sludge when nitrate was present. Nitrates 91-98 radixin Homo sapiens 24-27 28442008-4 2017 However, the biotransformation of RDX and HMX was negatively influenced, especially with high nitrate concentrations. Nitrates 94-101 radixin Homo sapiens 34-37 28442008-6 2017 The removal of RDX and HMX under both nitrate- and sulfate-enriched conditions was facilitated by the use of glucose as additional substrate. Nitrates 38-45 radixin Homo sapiens 15-18 28340298-1 2017 Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-). Nitrates 14-21 NBL1, DAN family BMP antagonist Homo sapiens 23-26 27487980-0 2017 Zn-biofortification enhanced nitrogen metabolism and photorespiration process in green leafy vegetable Lactuca sativa L. BACKGROUND: Excessive rates of nitrogen (N) fertilizers may result in elevated concentrations of nitrate (NO3- ) in plants. Nitrates 218-225 NBL1, DAN family BMP antagonist Homo sapiens 227-230 27921261-0 2017 Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle. Nitrates 81-88 nitric oxide synthase 1, neuronal Mus musculus 37-67 28391923-5 2017 During HEa and HEc, a shallow boundary layer, stagnant meteorological conditions, and high humidity favored the formation of high-nitrate concentrations, which were mainly produced by three different processes - daytime photochemical production, gas-particle partitioning, and nighttime heterogeneous reactions - and the decline in visibility was mainly induced by NR-PM1. Nitrates 130-137 NDC80 kinetochore complex component Homo sapiens 15-18 28339983-4 2017 A T-DNA insertion mutant of ACR11 exhibited a reduced GS activity under low nitrate conditions and reduced glutamine levels. Nitrates 76-83 uridylyltransferase-like protein Arabidopsis thaliana 28-33 28032637-0 2017 Nitrogen Limitation Adaptation (NLA) is involved in source-to-sink remobilization of nitrate by mediating the degradation of NRT1.7 in Arabidopsis. Nitrates 85-92 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 32-35 28032637-0 2017 Nitrogen Limitation Adaptation (NLA) is involved in source-to-sink remobilization of nitrate by mediating the degradation of NRT1.7 in Arabidopsis. Nitrates 85-92 nitrate transporter 1.1 Arabidopsis thaliana 125-129 28088722-2 2017 Empirical mass-balance (nitrogen in/nitrogen out) approaches for estimating nitrogen (N) removal in CWs do not characterise the final fate of N; where nitrate (NO3--N) could be reduced to either ammonium (NH4+-N) or N2 with the potential for significant production of N2O. Nitrates 151-158 NBL1, DAN family BMP antagonist Homo sapiens 160-163 28153714-2 2017 A significant source of NO is dietary nitrate (NO3), which is initially metabolized by oral bacteria into nitrite (NO2-) and is subsequently converted into NO once digested in the acidic gastric environment. Nitrates 38-45 NBL1, DAN family BMP antagonist Homo sapiens 47-50 28262888-3 2017 An SN2-type attack by -OR (-OR = phenoxide, acetate, difluoroacetate, and nitrate) then leads to C(sp3)-OR bond formation. Nitrates 74-81 solute carrier family 38 member 5 Homo sapiens 3-6 28319056-6 2017 These shoot-derived polypeptides, which we named CEP DOWNSTREAM 1 (CEPD1) and CEPD2, upregulate the expression of the nitrate transporter gene NRT2.1 in roots specifically when nitrate is present in the rhizosphere. Nitrates 118-125 nitrate transporter 2:1 Arabidopsis thaliana 143-149 28027473-2 2017 In this study, we aimed to reveal the microbial community dynamics in the ISDD process with different influent nitrate (NO3-) concentrations. Nitrates 111-118 NBL1, DAN family BMP antagonist Homo sapiens 120-123 27596480-1 2017 The feasibility of NO3- removal by the synergistic action of a prevailing denitrifying anoxic methane oxidising (DAMO), and nitrate-reducing and sulfide-oxidising bacterial (NR-SOB) consortium, using CH4 and H2 S from biogas as electron donors in a biotrickling filter was investigated. Nitrates 124-131 NBL1, DAN family BMP antagonist Homo sapiens 19-22 28028076-5 2017 We found that nitrate induces PGC1alpha expression and a switch toward type I and IIa fibers in rat muscle and myotubes in vitro. Nitrates 14-21 PPARG coactivator 1 alpha Rattus norvegicus 30-39 28028076-6 2017 Nitrate induces the release of exercise/PGC1alpha-dependent myokine FNDC5/irisin and beta-aminoisobutyric acid from myotubes and muscle in rats and humans. Nitrates 0-7 PPARG coactivator 1 alpha Rattus norvegicus 40-49 28028076-6 2017 Nitrate induces the release of exercise/PGC1alpha-dependent myokine FNDC5/irisin and beta-aminoisobutyric acid from myotubes and muscle in rats and humans. Nitrates 0-7 fibronectin type III domain containing 5 Rattus norvegicus 68-73 28028076-7 2017 Both exercise and nitrate stimulated PGC1alpha-mediated gamma-aminobutyric acid (GABA) secretion from muscle. Nitrates 18-25 PPARG coactivator 1 alpha Homo sapiens 37-46 28028076-8 2017 Circulating GABA concentrations were increased in exercising mice and nitrate-treated rats and humans; thus, GABA may function as an exercise/PGC1alpha-mediated myokine-like small molecule. Nitrates 70-77 PPARG coactivator 1 alpha Homo sapiens 142-151 27874191-6 2017 Limit of detection values were 6.7 and 4.3 muM for nitrate and nitrite, respectively. Nitrates 51-58 latexin Homo sapiens 43-46 28024935-1 2017 Uptake of inorganic nitrate (NO3-) into the salivary circulation is a rate-limiting step for dietary NO3- metabolism in mammals. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 29-32 27893932-1 2017 Subsurface brines with high nitrate (NO3- ) concentration are common in desert environments as atmospheric nitrogen is concentrated by the evaporation of precipitation and little nitrogen uptake. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 37-40 27894754-5 2017 Furthermore, the applicability of the proposed modified electrode was demonstrated by measuring the concentration of nitrite and nitrate ions in the tap and mineral waters, sausages, salami, and cheese samples. Nitrates 129-136 nuclear RNA export factor 1 Homo sapiens 149-152 28024935-1 2017 Uptake of inorganic nitrate (NO3-) into the salivary circulation is a rate-limiting step for dietary NO3- metabolism in mammals. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 101-104 28024935-6 2017 Salivary and plasma [NO3-] and [NO2-] were higher in the nitrate and nitrate + iodide trials compared to the control trial (P < 0.05). Nitrates 57-64 NBL1, DAN family BMP antagonist Homo sapiens 21-24 28024935-6 2017 Salivary and plasma [NO3-] and [NO2-] were higher in the nitrate and nitrate + iodide trials compared to the control trial (P < 0.05). Nitrates 69-76 NBL1, DAN family BMP antagonist Homo sapiens 21-24 29744302-8 2017 Presence of 40 mg L-1 nitrates caused reductive transformation of TCE up to 80%. Nitrates 22-30 immunoglobulin kappa variable 1-16 Homo sapiens 18-21 27682218-2 2017 In case of TBP and DHOA complexes, 3 ligand molecules coordinated in monodentate fashion and 3 nitrate ion in bidentate fashion to Eu3+ to satisfy the 9 coordination of Eu. Nitrates 95-102 TATA-box binding protein Homo sapiens 11-14 28224117-7 2017 We demonstrate that PerC controls anaerobic metabolism by increasing expression of genes necessary for nitrate reduction. Nitrates 103-110 Putative regulator Escherichia coli 20-24 28224117-8 2017 A tEPEC strain overexpressing PerC exhibited a growth advantage compared to a strain lacking this regulator, when grown anaerobically in the presence of nitrate, conditions mimicking the human intestine. Nitrates 153-160 PPARG coactivator 1 beta Homo sapiens 30-34 27890411-5 2017 The focus of this research is to study the impact of the heterogeneous hydrolysis of N2O5 on the formation of nitrate (NO3-) and ammonium (NH4+) in Beijing. Nitrates 110-117 NBL1, DAN family BMP antagonist Homo sapiens 119-122 27890411-8 2017 As a result, the hydrolysis of N2O5 led to 21.0% enhancement of nitrate (NO3-) and 7.5% enhancement of ammonium (NH4+). Nitrates 64-71 NBL1, DAN family BMP antagonist Homo sapiens 73-76 28032976-1 2017 Nitrate metabolism in Chlamydomonas reinhardtii involves THB1, a monomeric hemoglobin thought to function as a nitric oxide dioxygenase (NOD). Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 57-61 27847182-9 2017 Regional average NO3-N concentrations of groundwater increased coincidently with the increased use of fertilizer, which suggests that nitrate pollution is caused by agricultural activities. Nitrates 134-141 NBL1, DAN family BMP antagonist Homo sapiens 17-20 27852448-1 2017 High concentrations of naturally occurring arsenic (As) are typically found in young alluvial and deltaic deposits, and high concentrations of ammonium (NH4+) and nitrate (NO3-) are often present in groundwater affected by anthropogenic activities. Nitrates 163-170 NBL1, DAN family BMP antagonist Homo sapiens 172-175 27852448-2 2017 In this study, on the basis of physicochemical characteristics of groundwater and the nitrogen and oxygen isotope composition of NO3-, it was inferred that the main sources of NO3- in the proximal fan of the Choushui River alluvial fan are likely to be ammonium fertilizers, manure, and septic waste; that in the mid-fan and the distal fan, the possible sources are nitrate fertilizers and marine nitrate. Nitrates 366-373 NBL1, DAN family BMP antagonist Homo sapiens 176-179 27852448-2 2017 In this study, on the basis of physicochemical characteristics of groundwater and the nitrogen and oxygen isotope composition of NO3-, it was inferred that the main sources of NO3- in the proximal fan of the Choushui River alluvial fan are likely to be ammonium fertilizers, manure, and septic waste; that in the mid-fan and the distal fan, the possible sources are nitrate fertilizers and marine nitrate. Nitrates 397-404 NBL1, DAN family BMP antagonist Homo sapiens 176-179 27916563-1 2017 BACKGROUND: There is no epidemiological study on the association between dietary nitrate (NO3) and nitrite (NO2) and intakes and the risk of type 2 diabetes (T2D). Nitrates 81-88 NBL1, DAN family BMP antagonist Homo sapiens 90-93 27842004-2 2017 The compound is synthesized by nitrate route and is found to crystallize in monoclinic P21/n space group. Nitrates 31-38 H3 histone pseudogene 16 Homo sapiens 87-90 28025145-3 2017 Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis. Nitrates 78-85 BTB and TAZ domain protein 1 Arabidopsis thaliana 150-153 28025145-3 2017 Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis. Nitrates 78-85 BTB and TAZ domain protein 2 Arabidopsis thaliana 158-161 28025145-3 2017 Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis. Nitrates 118-125 BTB and TAZ domain protein 1 Arabidopsis thaliana 150-153 28025145-3 2017 Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis. Nitrates 118-125 BTB and TAZ domain protein 2 Arabidopsis thaliana 158-161 28025145-6 2017 These results suggest that direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis. Nitrates 155-162 BTB and TAZ domain protein 1 Arabidopsis thaliana 48-51 28025145-6 2017 These results suggest that direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis. Nitrates 155-162 BTB and TAZ domain protein 2 Arabidopsis thaliana 56-59 28057862-5 2017 We also show that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates. Nitrates 21-28 integrin alpha M Mus musculus 140-145 28057862-5 2017 We also show that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates. Nitrates 21-28 myeloperoxidase Mus musculus 162-177 27845046-2 2017 Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness. Nitrates 176-183 DHFS-FPGS homolog B Arabidopsis thaliana 41-46 28009868-7 2017 The microfluidic sensor provides an ultralow limit of detection of 0.01 mg L-1, a wide dynamic range from 0.01 to 442 mg L-1, and a high sensitivity of 683.3 muA mg-1 L cm-2 for nitrate ions in real soil solution samples. Nitrates 178-185 immunoglobulin kappa variable 1-16 Homo sapiens 75-78 28009868-7 2017 The microfluidic sensor provides an ultralow limit of detection of 0.01 mg L-1, a wide dynamic range from 0.01 to 442 mg L-1, and a high sensitivity of 683.3 muA mg-1 L cm-2 for nitrate ions in real soil solution samples. Nitrates 178-185 immunoglobulin kappa variable 1-16 Homo sapiens 121-124 27845046-2 2017 Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness. Nitrates 176-183 DHFS-FPGS homolog B Arabidopsis thaliana 104-109 29151838-1 2017 Anthropogenic nitrogen (N) emissions to the atmosphere have increased significantly the deposition of nitrate (NO3-) and ammonium (NH4+) to the surface waters of the open ocean, with potential impacts on marine productivity and the global carbon cycle. Nitrates 102-109 NBL1, DAN family BMP antagonist Homo sapiens 111-114 28067583-3 2017 The slow rise in root tip ABA levels stimulates expression of nitrate metabolic enzymes and simultaneously activates a negative feedback loop involving the protein phosphatase, ABI2, which reduces nitrate influx via the AtNPF6.3 transceptor. Nitrates 197-204 abl interactor 2 Homo sapiens 177-181 28067583-3 2017 The slow rise in root tip ABA levels stimulates expression of nitrate metabolic enzymes and simultaneously activates a negative feedback loop involving the protein phosphatase, ABI2, which reduces nitrate influx via the AtNPF6.3 transceptor. Nitrates 197-204 nitrate transporter 1.1 Arabidopsis thaliana 220-228 28212873-4 2017 The aim of our study was to evaluate the temperament and character personality dimensions in patients with VVS as confirmed by nitrate-induced tilt testing. Nitrates 127-134 VVS Homo sapiens 107-110 27773243-3 2017 The X-ray structure revealed that the Pb(II) atom is coordinated by one oxygen and three nitrogen atoms from two qcnh ligands and five oxygen atoms from three nitrate ligands in an 8+1 fashion with a PbN3O6 donor set. Nitrates 159-166 submaxillary gland androgen regulated protein 3B Homo sapiens 38-44 28683458-1 2017 Nitric oxide (NO) plays an important role in controlling microcirculatory function, but the effects of exogenous administration of nitrate (NO3-) on the microcirculation have not been well studied. Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 27908452-2 2017 In this study, we investigated the reactions of ozone with DON with a special emphasis on the formation of nitrate (NO3-) and ammonium (NH4+). Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 116-119 27794435-5 2017 However, after three weeks with in-cage running wheel, mice fed nitrate ran on average 20% faster and 30% further than controls (p<0.01). Nitrates 64-71 RAN, member RAS oncogene family Mus musculus 72-75 28009811-1 2016 BACKGROUND AND AIM: The association of habitual intakes of dietary nitrate (NO3-) and nitrite (NO2-) with blood pressure and renal function is not clear. Nitrates 67-74 NBL1, DAN family BMP antagonist Homo sapiens 76-79 27744007-2 2016 Cigarette smoking increases circulating thiocyanate (SCN-), which has been suggested to competitively inhibit salivary nitrate (NO3-) uptake, a rate-limiting step in dietary NO3- metabolism. Nitrates 119-126 NBL1, DAN family BMP antagonist Homo sapiens 128-131 27744007-2 2016 Cigarette smoking increases circulating thiocyanate (SCN-), which has been suggested to competitively inhibit salivary nitrate (NO3-) uptake, a rate-limiting step in dietary NO3- metabolism. Nitrates 119-126 NBL1, DAN family BMP antagonist Homo sapiens 174-177 27699705-5 2016 Parameters included the maximum specific reduction rates, [Formula: see text], growth rates, [Formula: see text], and yields, Y, for reduction of NO3- (nitrate) to nitrite (NO2-), NO2- to N2O, and N2O to N2, with acetate as the electron donor. Nitrates 152-159 NBL1, DAN family BMP antagonist Homo sapiens 146-149 27984871-1 2016 A nitrate ion (NO3-) with its trigonal planar geometry and charges distributed among nitrogen and oxygen atoms can couple to the extensive hydrogen bond network of water to give rise to unique dynamical characteristics. Nitrates 2-9 NBL1, DAN family BMP antagonist Homo sapiens 15-18 27984871-10 2016 In the first mechanism, nitrate ion predominantly undergoes out-of-plane rotation, while in the second mechanism, in-plane reorientation of NO3- is favourable. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 140-143 27646453-1 2016 This study builds upon prior work showing that methane (CH4) could be utilized as the sole electron donor and carbon source in a membrane biofilm reactor (MBfR) for complete perchlorate (ClO4-) and nitrate (NO3-) removal. Nitrates 198-205 NBL1, DAN family BMP antagonist Homo sapiens 207-210 27694216-1 2016 We tested the hypothesis that dietary nitrate (NO3-)-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation. Nitrates 38-45 NBL1, DAN family BMP antagonist Homo sapiens 47-50 27643659-3 2016 As nitrate loading gradually increased to 5 mg/L (stage 2), perchlorate reduction was slightly promoted and both ClO4- and NO3- were completely removed at an acetate loading of 29.7 mg C/L. Nitrates 3-10 NBL1, DAN family BMP antagonist Homo sapiens 123-126 27643659-4 2016 When nitrate loading continued increasing to 10-60 mg/L (stage 3), perchlorate reduction converted to be inhibited, along with nondetectable NO3- and approximately exhausted DOC in effluent. Nitrates 5-12 NBL1, DAN family BMP antagonist Homo sapiens 141-144 27541496-2 2016 Atnpf3.1 mutants are affected in hypocotyl elongation and seed germination under conditions of low-nitrate availability. Nitrates 99-106 Major facilitator superfamily protein Arabidopsis thaliana 0-8 27541496-6 2016 We further analyzed its substrate specificity towards different GA species using a yeast heterologous system which revealed that (1) NPF3.1 transported not only bioactive GAs but also their precursors and metabolites and (2) the GAs" import activity of NPF3.1 was not affected by the presence of exogenous nitrate. Nitrates 306-313 Major facilitator superfamily protein Arabidopsis thaliana 133-139 27541496-6 2016 We further analyzed its substrate specificity towards different GA species using a yeast heterologous system which revealed that (1) NPF3.1 transported not only bioactive GAs but also their precursors and metabolites and (2) the GAs" import activity of NPF3.1 was not affected by the presence of exogenous nitrate. Nitrates 306-313 Major facilitator superfamily protein Arabidopsis thaliana 253-259 27541496-12 2016 In addition, NPF3.1 gene expression was upregulated by low exogenous nitrate concentrations and the npf3.1 mutants exhibited a not yet described GA-related phenotype under these conditions. Nitrates 69-76 Major facilitator superfamily protein Arabidopsis thaliana 13-19 27541496-13 2016 All together, these results indicated that NPF3.1 is indeed involved in GAs transport in planta under low-nitrate conditions. Nitrates 106-113 Major facilitator superfamily protein Arabidopsis thaliana 43-49 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 nitrate reductase [NADH] Solanum lycopersicum 50-67 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 nitrate reductase [NADH] Solanum lycopersicum 69-71 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 ferredoxin--nitrite reductase, chloroplastic Solanum lycopersicum 74-91 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 ferredoxin--nitrite reductase, chloroplastic Solanum lycopersicum 93-96 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 glutamate dehydrogenase Solanum lycopersicum 201-224 27639963-7 2016 Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend. Nitrates 0-7 glutamate dehydrogenase Solanum lycopersicum 226-229 27907130-2 2016 The rate of nitrate increase in the river as documented by Ham and Hatzell (1996) was 0.02 mg N L-1 y-1. Nitrates 12-19 dull endosperm 1 Zea mays 59-62 27732867-2 2016 Nitrate levels up to the WHO guideline maximum of 50 mg NO3-/L were used in tests. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 56-59 27419465-5 2016 Similar rapid transcriptional repression occurred in loss-of-function mutants of the nitrate response factor NLP7 and some transcripts were stabilized by nitrate. Nitrates 85-92 NIN like protein 7 Arabidopsis thaliana 109-113 27419465-5 2016 Similar rapid transcriptional repression occurred in loss-of-function mutants of the nitrate response factor NLP7 and some transcripts were stabilized by nitrate. Nitrates 154-161 NIN like protein 7 Arabidopsis thaliana 109-113 27593618-1 2016 BACKGROUND: Dietary inorganic nitrate (NO3-) and its reduced forms nitrite (NO2-) and nitric oxide (NO), respectively, are of critical importance for host defense in the oral cavity. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 39-42 27613099-8 2016 eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01). Nitrates 142-149 nitric oxide synthase 3 Homo sapiens 0-4 27613099-8 2016 eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01). Nitrates 142-149 pyruvate kinase M1/2 Homo sapiens 26-29 27933040-2 2016 A known important factor in this microbial competition is the ratio of available electron donor and elector acceptor, here expressed as Ac/N ratio (acetate/nitrate-nitrogen). Nitrates 156-163 apoptotic chromatin condensation inducer 1 Homo sapiens 136-140 27933040-3 2016 We studied the impact of the Ac/N ratio on the nitrate reduction pathways in chemostat enrichment cultures, grown on acetate mineral medium. Nitrates 47-54 apoptotic chromatin condensation inducer 1 Homo sapiens 29-33 27933040-7 2016 Interestingly, in a broad range of Ac/N ratios a dual limitation of acetate and nitrate occurred with co-occurrence of DNRA bacteria and denitrifiers. Nitrates 80-87 apoptotic chromatin condensation inducer 1 Homo sapiens 35-39 27572691-1 2016 Nitrate (NO3-) pollution is a severe problem in urban aquatic systems especially within megacity undergoing rapid urbanization, and mostly, sewage is supposed as the prevailing NO3- source. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 27418517-6 2016 At night, nitrate was mainly formed through the hydrolysis of NO3 and/or N2O5. Nitrates 10-17 NBL1, DAN family BMP antagonist Homo sapiens 62-65 27572525-5 2016 RESULTS: Results indicate that LBP treatment improved sperm density, sperm movement, the rate of normal sperm morphology, and protein expression and superoxide dismutase activity in the testes of the mice and decreased the nitrate nitrogen level in the testes of the mice. Nitrates 223-230 lipopolysaccharide binding protein Mus musculus 31-34 27572691-1 2016 Nitrate (NO3-) pollution is a severe problem in urban aquatic systems especially within megacity undergoing rapid urbanization, and mostly, sewage is supposed as the prevailing NO3- source. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 177-180 27898774-0 2016 Effects of Feeding Encapsulated Nitrate to Beef Cattle on Ammonia and Greenhouse Gas Emissions from Their Manure in a Short-Term Manure Storage System. Nitrates 32-39 gastrin Bos taurus 81-84 27124387-1 2016 In forests of the humid subtropics of China, chronically elevated nitrogen (N) deposition, predominantly as ammonium (NH4+ ), causes significant nitrate (NO3- ) leaching from well-drained acid forest soils on hill slopes (HS), whereas significant retention of NO3- occurs in near-stream environments (groundwater discharge zones, GDZ). Nitrates 145-152 NBL1, DAN family BMP antagonist Homo sapiens 154-157 27124387-2 2016 To aid our understanding of N transformations on the catchment level, we studied spatial and temporal variabilities of concentration and natural abundance (delta15 N and delta18 O) of nitrate (NO3- ) in soil pore water along a hydrological continuum in the N-saturated Tieshanping (TSP) catchment, southwest China. Nitrates 184-191 NBL1, DAN family BMP antagonist Homo sapiens 193-196 27898774-1 2016 A study was conducted to investigate effects of feeding encapsulated nitrate (EN) to beef cattle on ammonia (NH) and greenhouse gas emissions from their manure. Nitrates 69-76 gastrin Bos taurus 128-131 27355518-7 2016 Enrichment of (15)N and (18)O in nitrate is consistent with lithotrophic denitrification of NO3 in the presence of dissolved Mn and Fe. Nitrates 33-40 NBL1, DAN family BMP antagonist Homo sapiens 92-95 27418276-5 2016 In contrast, the 17 O anomaly in nitrate (NO3-) in Lake Vida brine indicates that approximately half or more of the NO3- present is derived from atmospheric deposition. Nitrates 33-40 NBL1, DAN family BMP antagonist Homo sapiens 42-45 27588710-4 2016 In avr P. infestans potato leaves enhanced NR gene and protein expression was tuned with the depletion of nitrate contents and the increase in nitrite supply at 3 hpi. Nitrates 106-113 NADH nitrate reductase Solanum tuberosum 43-45 27593859-6 2016 RESULTS: SIN-1 treatment increased arginase activity in a time- and dose-dependent manner and reciprocally decreased nitrite/nitrate production that was prevented by peroxynitrite scavenger in HUVECs. Nitrates 125-132 MAPK associated protein 1 Homo sapiens 9-14 27314899-1 2016 Many karst regions are undergoing rapid population growth and expansion of urban land accompanied by increases in wastewater generation and changing patterns of nitrate (NO3(-)) loading to surface and groundwater. Nitrates 161-168 NBL1, DAN family BMP antagonist Homo sapiens 170-173 27618259-6 2016 This may represent a different mechanism from P25, where nitrate is mainly reduced by CO2 - radicals generated by the holes at the valence band. Nitrates 57-64 complement C2 Homo sapiens 86-89 27702902-1 2016 Natural abundance nitrogen and oxygen isotopes of nitrate (delta15NNO3 and delta18ONO3) provide an important tool for evaluating sources and transformations of natural and contaminant nitrate (NO3-) in the environment. Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 67-70 27435853-5 2016 Moreover, HY5 acts as a signal that moves from shoot to root to promote nitrate uptake and root growth. Nitrates 72-79 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 10-13 27731416-0 2016 NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis. Nitrates 44-51 Plant regulator RWP-RK family protein Arabidopsis thaliana 0-18 27731416-3 2016 Here we show that the Arabidopsis NIN-like protein 8 (NLP8) is essential for nitrate-promoted seed germination. Nitrates 77-84 Plant regulator RWP-RK family protein Arabidopsis thaliana 34-52 27731416-3 2016 Here we show that the Arabidopsis NIN-like protein 8 (NLP8) is essential for nitrate-promoted seed germination. Nitrates 77-84 Plant regulator RWP-RK family protein Arabidopsis thaliana 54-58 27626106-4 2016 In our tests (eight instruments, n = 29), ammonium nitrate (NH4NO3) causes a median CO2+ interference signal of +3.4% relative to nitrate. Nitrates 51-58 complement C2 Homo sapiens 84-87 27731416-6 2016 NLP8 reduces abscisic acid levels in a nitrate-dependent manner and directly binds to the promoter of CYP707A2, encoding an abscisic acid catabolic enzyme. Nitrates 39-46 Plant regulator RWP-RK family protein Arabidopsis thaliana 0-4 27731416-7 2016 Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2. Nitrates 75-82 Plant regulator RWP-RK family protein Arabidopsis thaliana 28-32 27731416-7 2016 Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2. Nitrates 75-82 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 92-100 29964426-1 2016 Based on test results and mass balance, PHA, TP metabolic regularity was revealed under different nitrate nitrogen concentrations in main anoxic stage [c(NO3)] for nitrogen and phosphorus removal in single sludge system with continuous flow, then the effectiveness of using c(NO3) as control parameter was proved from the perspective of the reaction mechanism. Nitrates 98-105 NBL1, DAN family BMP antagonist Homo sapiens 276-279 27849257-14 2016 CONCLUSION: Dietary nitrate in diabetic rats provides cardioprotection against IR injury by regulating eNOS and iNOS expression and inhibiting lipid peroxidation in the heart. Nitrates 20-27 nitric oxide synthase 2 Rattus norvegicus 112-116 27474450-0 2016 Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation. Nitrates 8-15 angiotensinogen Rattus norvegicus 104-118 27474450-4 2016 This study was designed to test the hypothesis that dietary nitrate supplementation could reduce blood pressure and improve glucose tolerance in aged rats, via attenuation of NADPH oxidase activity and ANG II receptor signaling. Nitrates 60-67 angiotensinogen Rattus norvegicus 202-208 27474450-8 2016 Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Nitrates 9-16 angiotensinogen Rattus norvegicus 82-88 27474450-8 2016 Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Nitrates 9-16 angiotensin II receptor, type 1a Rattus norvegicus 100-104 27519268-0 2016 Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-/- mouse fed a high fat diet. Nitrates 17-24 apolipoprotein E Mus musculus 86-90 27474450-8 2016 Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Nitrates 9-16 angiotensin II receptor, type 2 Rattus norvegicus 106-109 27519268-13 2016 CONCLUSION: Low and moderate dose nitrate significantly improved endothelial function and atherosclerotic plaque composition in ApoE-/- mice fed a HFD. Nitrates 34-41 apolipoprotein E Mus musculus 128-132 27474450-8 2016 Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Nitrates 9-16 angiotensin II receptor, type 1a Rattus norvegicus 111-115 27474450-8 2016 Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II. Nitrates 9-16 angiotensin II receptor, type 2 Rattus norvegicus 116-119 27474450-9 2016 Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression. Nitrates 35-42 angiotensinogen Rattus norvegicus 191-197 27609225-0 2016 Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis. Nitrates 61-68 xanthine dehydrogenase Mus musculus 9-12 27609225-0 2016 Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis. Nitrates 61-68 nitric oxide synthase 3, endothelial cell Mus musculus 25-29 27609225-8 2016 Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Nitrates 27-34 nitric oxide synthase 3, endothelial cell Mus musculus 69-73 27609225-8 2016 Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat. Nitrates 27-34 xanthine dehydrogenase Mus musculus 154-157 27609225-10 2016 Dietary supplementation with nitrate increased XOR expression and activity, but concomitantly reduced superoxide generation. Nitrates 29-36 xanthine dehydrogenase Mus musculus 47-50 27609225-13 2016 A high dose of dietary nitrate reduced blood pressure in naive eNOS-/- mice, and again this effect was abolished by febuxostat. Nitrates 23-30 nitric oxide synthase 3, endothelial cell Mus musculus 63-67 27609225-14 2016 In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. Nitrates 90-97 nitric oxide synthase 3, endothelial cell Mus musculus 15-19 27609225-14 2016 In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS. Nitrates 90-97 xanthine dehydrogenase Mus musculus 69-72 27745660-4 2016 Higher concentrations of sulfate (SO42-) and organic carbon (OC) in PM2.5 occurred in fall and summer, while higher concentrations of nitrate (NO3-) were observed in winter and spring. Nitrates 134-141 NBL1, DAN family BMP antagonist Homo sapiens 143-146 27594514-0 2016 Nitrate salts suppress sporulation and production of enterotoxin in Clostridium perfringens strain NCTC8239. Nitrates 0-13 cpe Clostridium perfringens 53-64 27406851-6 2016 In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0). Nitrates 42-49 mitochondrially encoded cytochrome c oxidase III Homo sapiens 95-98 27406851-6 2016 In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0). Nitrates 42-49 mitochondrially encoded cytochrome c oxidase III Homo sapiens 109-116 27509322-0 2016 Kinetic and Theoretical Study of the Nitrate (NO3) Radical Gas Phase Reactions with N-Nitrosodimethylamine and N-Nitrosodiethylamine. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 46-49 27590123-7 2016 We suggest that nitrate and Zn2+ activate a late slower component of the DeltaF/F signals of frog but not of mouse fibres, possibly promoting Ca2+ induced Ca2+ release at level of the RyR3, that in frog muscle fibres are localized in the para-junctional region of the triads and are absent in mouse FDB muscle fibres. Nitrates 16-23 ryanodine receptor 3 Mus musculus 184-188 27543115-0 2016 Nitrate Controls Root Development through Posttranscriptional Regulation of the NRT1.1/NPF6.3 Transporter/Sensor. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 80-84 27543115-2 2016 In Arabidopsis (Arabidopsis thaliana), the adaptive root response to nitrate (NO3-) depends on the NRT1.1/NPF6.3 transporter/sensor. Nitrates 69-76 nitrate transporter 1.1 Arabidopsis thaliana 99-112 27585373-4 2016 Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 11-14 27585373-4 2016 Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 30-33 27585373-7 2016 Theoretical studies show crossing from the high-spin to low-spin surface upon neutral oxygen atom transfer from the nitrate ligand in [MnO2(NO3)](-) allows formation of (1)[MnO4](-). Nitrates 116-123 NBL1, DAN family BMP antagonist Homo sapiens 140-143 27280428-11 2016 ACh-induced vascular nitrate/nitrite production was in Preg+sFlt-1 and RUPP < Preg, and in RUPP+PlGF > RUPP. Nitrates 21-28 placental growth factor Rattus norvegicus 99-103 27593275-3 2016 The aim of this study was therefore to assess how maximum potential denitrification and N2O production rates, and the relationship between the two (relative N2O production), is controlled by availability of nitrate (NO3(-)), carbon (C), phosphorus (P), and temperature. Nitrates 207-214 NBL1, DAN family BMP antagonist Homo sapiens 216-219 26641379-2 2016 NO availability increases after consuming nitrate (NO3-). Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 51-54 27481896-8 2016 A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity. Nitrates 46-53 cysteine synthase Cucumis sativus 165-181 27481896-8 2016 A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity. Nitrates 46-53 cysteine synthase Cucumis sativus 183-185 27481896-8 2016 A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity. Nitrates 46-53 cysteine synthase Cucumis sativus 221-223 26896377-4 2016 In the present research, beta-lactoglobulin-pectin nanoparticles were designed to transfer a newly synthesized, anticancer platinum complex (bipyridine ethyl dithiocarbamate Pt(II) nitrate), to the colon. Nitrates 181-188 beta-lactoglobulin Bos taurus 25-43 27397895-9 2016 SLAH3 anion channels are not active per se but require extracellular nitrate and phosphorylation by calcium-dependent kinases (CPKs) [11-13]. Nitrates 69-76 SLAC1 homologue 3 Arabidopsis thaliana 0-5 27397895-10 2016 When co-expressed in Xenopus oocytes, however, the electrically silent SLAH1 subunit gates SLAH3 open even in the absence of nitrate- and calcium-dependent kinases. Nitrates 125-132 SLAC1 homologue 1 Arabidopsis thaliana 71-76 27194250-5 2016 Nitrate was correlated with Na(+) + K(+), Mg(2+), Cl(-) and SO4 (2-) in the shallow aquifer, and the spatial distributions of NO3 (-) exhibited a same pattern with TDS in the shallow aquifer, the NO3 (-) pollution in the middle-deep and deep aquifers is less serious. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 126-129 27194250-5 2016 Nitrate was correlated with Na(+) + K(+), Mg(2+), Cl(-) and SO4 (2-) in the shallow aquifer, and the spatial distributions of NO3 (-) exhibited a same pattern with TDS in the shallow aquifer, the NO3 (-) pollution in the middle-deep and deep aquifers is less serious. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 196-199 27208469-2 2016 This key step in thyroid hormone synthesis is inhibited by perchlorate, thiocyanate (SCN) and nitrate (NO3) anions. Nitrates 94-101 NBL1, DAN family BMP antagonist Homo sapiens 103-106 27236758-7 2016 Methane production [L/kg of dry matter intake (DMI)] linearly decreased with increasing nitrate concentrations compared with the control, corresponding to a reduction of 6, 13, and 23% for the low, medium, and high diets, respectively. Nitrates 88-95 DMI Bos taurus 47-50 27456694-6 2016 In 26 % of the water samples, nitrate concentration is above the human-affected value, 5 mg/l NO3 (-). Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 94-97 27456694-12 2016 Loading of factors with K(+) and SO4 (2-), K(+) and NO3 (-), and NO3 (-) and correlation of SO4 (2-) with Cl(-), along with the observed high nitrate concentration, indicate the effect of surface contamination sources on the water quality. Nitrates 142-149 NBL1, DAN family BMP antagonist Homo sapiens 52-55 27456694-12 2016 Loading of factors with K(+) and SO4 (2-), K(+) and NO3 (-), and NO3 (-) and correlation of SO4 (2-) with Cl(-), along with the observed high nitrate concentration, indicate the effect of surface contamination sources on the water quality. Nitrates 142-149 NBL1, DAN family BMP antagonist Homo sapiens 65-68 26630309-2 2016 Acute nitrate supplementation, at sea level, may reduce oxygen cost during submaximal exercise in hypobaric hypoxia. Nitrates 6-13 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 34-37 27236758-9 2016 Addition of nitrate increased hydrogen emissions (L/kg of DMI) quadratically by a factor of 2.5, 3.4, and 3.0 (as L/kg of DMI) for the low, medium, and high diets, respectively, compared with the control. Nitrates 12-19 DMI Bos taurus 58-61 27236758-9 2016 Addition of nitrate increased hydrogen emissions (L/kg of DMI) quadratically by a factor of 2.5, 3.4, and 3.0 (as L/kg of DMI) for the low, medium, and high diets, respectively, compared with the control. Nitrates 12-19 DMI Bos taurus 122-125 27236758-10 2016 Blood methemoglobin levels and nitrate concentrations in milk and urine increased with increasing nitrate intake, but did not constitute a threat for animal health and human food safety. Nitrates 98-105 hemoglobin subunit gamma 2 Homo sapiens 6-19 27102809-1 2016 Natural abundance nitrate (NO3 (-)) isotopes represent a powerful tool for assessing denitrification, yet the scale and context dependence of relationships between isotopes and denitrification have received little attention, especially in surface soils. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 27340232-4 2016 Artificial microRNA knockdown mutants of AtSLAH1 had significantly reduced shoot Cl(-) accumulation when grown under low Cl(-), whereas shoot Cl(-) increased and the shoot nitrate/chloride ratio decreased following AtSLAH1 constitutive or stelar-specific overexpression when grown in high Cl(-) In both sets of overexpression lines a significant reduction in shoot biomass over the null segregants was observed under high Cl(-) supply, but not low Cl(-) supply. Nitrates 172-179 SLAC1 homologue 1 Arabidopsis thaliana 41-48 27340232-5 2016 Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport. Nitrates 73-80 SLAC1 homologue 3 Arabidopsis thaliana 30-37 27340232-5 2016 Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport. Nitrates 131-138 SLAC1 homologue 3 Arabidopsis thaliana 30-37 27340232-5 2016 Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport. Nitrates 131-138 SLAC1 homologue 3 Arabidopsis thaliana 113-120 27435462-4 2016 Generation of nitrate in the intestinal lumen required inducible nitric oxide synthase (iNOS), which was synthesized constitutively in the mucosa of the terminal ileum but not in the jejunum, duodenum, or cecum. Nitrates 14-21 nitric oxide synthase 2, inducible Mus musculus 88-92 27435462-10 2016 This pathway required the methyl-accepting chemotaxis protein (MCP) Tsr and energy taxis toward host-derived nitrate, which we found to be generated by inducible nitric oxide synthase (iNOS) in the ileal mucosa prior to infection. Nitrates 109-116 nitric oxide synthase 2, inducible Mus musculus 185-189 26864608-5 2016 Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants. Nitrates 78-85 nitrate transporter 1.1 Arabidopsis thaliana 8-14 27131407-3 2016 The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 27131407-3 2016 The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 139-142 26864608-5 2016 Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants. Nitrates 78-85 nitrate transporter 1.1 Arabidopsis thaliana 27-31 26864608-5 2016 Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants. Nitrates 78-85 nitrate transporter 1.1 Arabidopsis thaliana 8-12 26864608-6 2016 Another nrt1.1 point mutant, which is defective in nitrate uptake but has a normal nitrate-sensing function, also had impaired proton tolerance compared with the wild-type plant. Nitrates 51-58 nitrate transporter 1.1 Arabidopsis thaliana 8-12 26864608-6 2016 Another nrt1.1 point mutant, which is defective in nitrate uptake but has a normal nitrate-sensing function, also had impaired proton tolerance compared with the wild-type plant. Nitrates 83-90 nitrate transporter 1.1 Arabidopsis thaliana 8-12 26864608-7 2016 Furthermore, proton stress induced NRT1.1-mediated nitrate uptake. Nitrates 51-58 nitrate transporter 1.1 Arabidopsis thaliana 35-39 26864608-8 2016 These results indicate that NRT1.1-conferred proton tolerance depends on nitrate uptake activity. Nitrates 73-80 nitrate transporter 1.1 Arabidopsis thaliana 28-32 26864608-10 2016 We conclude that NRT1.1-mediated nitrate uptake plays a crucial role in plant proton tolerance by alkalifying the rhizosphere. Nitrates 33-40 nitrate transporter 1.1 Arabidopsis thaliana 17-21 27323160-9 2016 Overexpression of ALDH2 increased cell survival against GTN-induced cytotoxicity and conferred protection from oxidative damage resulting from nitrate tolerance, accompanied by decreased production of intracellular reactive oxygen species and reduced expression of heme oxygenase 1. Nitrates 143-150 aldehyde dehydrogenase 2 family member Homo sapiens 18-23 27208280-6 2016 Employing these putative bacterial AvrRpt2 homologs and inactive AvrRpt2 variants, we can uncouple the inhibition of MPK4/MPK11 activation from the cleavage of RIN4 and related members from the so-called nitrate-induced family as well as from auxin signaling. Nitrates 204-211 MAP kinase 4 Arabidopsis thaliana 117-121 27208280-6 2016 Employing these putative bacterial AvrRpt2 homologs and inactive AvrRpt2 variants, we can uncouple the inhibition of MPK4/MPK11 activation from the cleavage of RIN4 and related members from the so-called nitrate-induced family as well as from auxin signaling. Nitrates 204-211 RPM1 interacting protein 4 Arabidopsis thaliana 160-164 27197029-7 2016 Within-batch and inter-batch replication yields 1 standard deviation (SD) of <=0.06% for delta(15) N values and <=0.14% for delta(18) O values down to 5 muM nitrate and <=0.08% and <=0.23% at 2 and 1 muM. Nitrates 163-170 latexin Homo sapiens 159-162 26846474-3 2016 Nonetheless, gating of the R117H-CFTR can be improved by a variety of pharmacological reagents supposedly acting on NBDs such as ATP analogues, or TMDs (e.g. VX-770 or nitrate). Nitrates 168-175 CF transmembrane conductance regulator Homo sapiens 33-37 26846474-12 2016 Moreover, our data demonstrate that a synergistic improvement of R117H-CFTR function can be accomplished with a combined regiment of VX-770 (Ivacaftor), nitrate ion (NO3 (-) ) and N(6) -(2-phenylethyl)-2"-deoxy-ATP (d-PATP), which almost completely rectifies the gating defect of R117H-CFTR. Nitrates 153-160 CF transmembrane conductance regulator Homo sapiens 71-75 27171587-0 2016 Decay Mechanism of NO3( ) Radical in Highly Concentrated Nitrate and Nitric Acidic Solutions in the Absence and Presence of Hydrazine. Nitrates 57-64 NBL1, DAN family BMP antagonist Homo sapiens 19-22 27208309-7 2016 We found NUE decreased in plants overexpressing BT2 gene compared to wild-type plants under limiting nitrate conditions. Nitrates 101-108 BTB and TAZ domain protein 2 Arabidopsis thaliana 48-51 27208309-8 2016 In addition, NUE increased compared to wild-type plants under low nitrate conditions in double mutant plants in bt2 and its closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE. Nitrates 66-73 BTB and TAZ domain protein 2 Arabidopsis thaliana 112-115 27208309-8 2016 In addition, NUE increased compared to wild-type plants under low nitrate conditions in double mutant plants in bt2 and its closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE. Nitrates 66-73 BTB and TAZ domain protein 1 Arabidopsis thaliana 148-151 27208309-9 2016 Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions. Nitrates 18-25 BTB and TAZ domain protein 1 Arabidopsis thaliana 79-82 27208309-9 2016 Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions. Nitrates 18-25 BTB and TAZ domain protein 2 Arabidopsis thaliana 83-86 27208309-9 2016 Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions. Nitrates 166-173 BTB and TAZ domain protein 1 Arabidopsis thaliana 79-82 28328022-1 2016 RATIONALE: The azide method for measuring the stable isotope ratios of nitrate (NO3- ) is easy to set up. Nitrates 71-78 NBL1, DAN family BMP antagonist Homo sapiens 80-83 27243218-10 2016 Furthermore, the concentrations of nitric oxide, nitrite, nitrate, and the ferric reducing ability of plasma decreased with AAC indicating a lower oxidative stress status. Nitrates 58-65 glycine N-acyltransferase Bos taurus 124-127 27211528-6 2016 Expression levels of RD22, RD29A, DREB2A, and P5CS1 decreased after nitrate treatment in SoHb-overexpressing plants, while increased in the WT plants. Nitrates 68-75 BURP domain-containing protein Arabidopsis thaliana 21-25 27211528-6 2016 Expression levels of RD22, RD29A, DREB2A, and P5CS1 decreased after nitrate treatment in SoHb-overexpressing plants, while increased in the WT plants. Nitrates 68-75 delta1-pyrroline-5-carboxylate synthase 1 Arabidopsis thaliana 46-51 27506022-3 2016 The results showed that the study region in the southeast was the main nitrate-polluted area, with concentrations of up to 30-120 mg L-1, in both wet and drought periods, while the nitrate-contaminated area in drought period was about 1. Nitrates 71-78 immunoglobulin kappa variable 1-16 Homo sapiens 135-138 27506022-6 2016 The nitrate concentration was less than 20 mg L-1 in north. Nitrates 4-11 immunoglobulin kappa variable 1-16 Homo sapiens 48-51 26969694-1 2016 UNLABELLED: Members of the Fungi convert nitrate (NO3 (-)) and nitrite (NO2 (-)) to gaseous nitrous oxide (N2O) (denitrification), but the fungal contributions to N loss from soil remain uncertain. Nitrates 41-48 NBL1, DAN family BMP antagonist Homo sapiens 50-53 26879980-3 2016 Biological nitrification of ammonia to nitrite (NO2 (-)) and nitrate (NO3 (-)) was mediated by nitrifying bacterial and archaeal biofilm populations. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 27000467-2 2016 We have recently shown that rodent skeletal muscle contains unusually high concentrations of nitrate, compared to blood and other tissues, likely produced by oxidation of NOS1-produced NO. Nitrates 93-100 nitric oxide synthase 1 Rattus norvegicus 171-175 27000467-6 2016 Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself. Nitrates 170-177 xanthine dehydrogenase Rattus norvegicus 61-84 27000467-1 2016 The presence of nitric oxide (NO) synthase enzymes, mainly the NOS1 isoform, in skeletal muscle had been well established; however in the last decade it has been realized that NO may also be produced by reduction of nitrate and tissue nitrite. Nitrates 216-223 nitric oxide synthase 1 Rattus norvegicus 63-67 27000467-6 2016 Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself. Nitrates 170-177 xanthine dehydrogenase Rattus norvegicus 86-89 26926793-0 2016 NAR2.1/NRT2.1 functional interaction with NO3(-) and H(+) fluxes in high-affinity nitrate transport in maize root regions. Nitrates 82-89 high affinity nitrate transporter Zea mays 0-6 26926793-0 2016 NAR2.1/NRT2.1 functional interaction with NO3(-) and H(+) fluxes in high-affinity nitrate transport in maize root regions. Nitrates 82-89 nitrate transport 2 Zea mays 7-11 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 47-54 high affinity nitrate transporter Zea mays 112-118 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 47-54 nitrate transport 2 Zea mays 123-129 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 47-54 nitrate transport 2 Zea mays 201-207 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 47-54 high affinity nitrate transporter Zea mays 208-214 26938500-3 2016 When 5000 muM nitrate was further added to the influent, total Se removal was again better under thermophilic (70.1 +- 6.6%) when compared to mesophilic (43.6 +- 8.8%) conditions. Nitrates 14-21 latexin Homo sapiens 10-13 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 241-248 high affinity nitrate transporter Zea mays 112-118 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 241-248 nitrate transport 2 Zea mays 123-129 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 241-248 nitrate transport 2 Zea mays 201-207 26926793-6 2016 A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis. Nitrates 241-248 high affinity nitrate transporter Zea mays 208-214 27010702-5 2016 When nitrate (NO3) radicals are suppressed, high isoprene persists through the night, providing photochemical fuel upon daybreak and leading to a dramatic late-morning ozone peak. Nitrates 5-12 NBL1, DAN family BMP antagonist Homo sapiens 14-17 26786906-3 2016 The simultaneous separation and sensitive detection of sodium (Na(+)), potassium (K(+)), ammonium (NH4 (+)), chloride (Cl(-)) and nitrate (NO3 (-)) in a single run was achieved by using 98% 1.5 mM MgSO4 and 2% acetonitrile eluent with a mixed-bed ion-exchange separation column without suppressor column system. Nitrates 130-137 NBL1, DAN family BMP antagonist Homo sapiens 139-142 26828278-1 2016 Zinc-aluminum layered double hydroxides with nitrate intercalated (Zn(n)Al-NO3, n=Zn/Al) is an intermediate material for the intercalation of different functional molecules used in a wide range of industrial applications. Nitrates 45-52 NBL1, DAN family BMP antagonist Homo sapiens 75-78 26841230-8 2016 The nitrate and sulfite induced indirect TOX photolysis rates were less than 50% of the direct photolysis rates under the conditions of this study. Nitrates 4-11 thymocyte selection associated high mobility group box Homo sapiens 41-44 26828284-2 2016 Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II). Nitrates 116-123 NBL1, DAN family BMP antagonist Homo sapiens 22-25 26828284-2 2016 Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II). Nitrates 116-123 NBL1, DAN family BMP antagonist Homo sapiens 33-36 26682792-4 2016 RESULTS: In myocardium of HFpEF patients and ZSF1-HFpEF rats, we observed the following: 1) E-selectin and intercellular adhesion molecule-1 expression levels were upregulated; 2) NADPH oxidase 2 expression was raised in macrophages and endothelial cells but not in cardiomyocytes; and 3) uncoupling of endothelial nitric oxide synthase, which was associated with reduced myocardial nitrite/nitrate concentration, cGMP content, and PKG activity. Nitrates 391-398 cytochrome b-245 beta chain Rattus norvegicus 180-195 27064357-1 2016 Nutrient stoichiometry within a wetland is affected by the surrounding land use, and may play a significant role in the removal of nitrate (NO3-N). Nitrates 131-138 NBL1, DAN family BMP antagonist Homo sapiens 140-143 27004464-1 2016 The family of NITRATE TRANSPORTER 2 (NRT2) proteins belongs to the high affinity transport system (HATS) proteins which acts at low nitrate concentrations. Nitrates 132-139 nitrate transporter 2:1 Arabidopsis thaliana 14-35 27004464-1 2016 The family of NITRATE TRANSPORTER 2 (NRT2) proteins belongs to the high affinity transport system (HATS) proteins which acts at low nitrate concentrations. Nitrates 132-139 nitrate transporter 2:1 Arabidopsis thaliana 37-41 26919711-4 2016 The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2. Nitrates 229-236 NBL1, DAN family BMP antagonist Homo sapiens 33-36 26799712-7 2016 The model simulation results also show that the sulphur term (eta(S)) in the kinetic equations of nitrate, nitrite, sulphur and sulphate remains constant, rather than being controlled by its own concentration. Nitrates 98-105 endothelin receptor type A Homo sapiens 62-65 26919711-4 2016 The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2. Nitrates 229-236 NBL1, DAN family BMP antagonist Homo sapiens 93-96 26919711-4 2016 The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2. Nitrates 229-236 NBL1, DAN family BMP antagonist Homo sapiens 93-96 26919711-4 2016 The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2. Nitrates 229-236 NBL1, DAN family BMP antagonist Homo sapiens 93-96 26919711-4 2016 The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2. Nitrates 229-236 NBL1, DAN family BMP antagonist Homo sapiens 93-96 26919711-6 2016 The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 100-103 26919711-6 2016 The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 118-121 26958096-0 2016 Effect of calcitonin gene-related peptide antagonist on the cardiovascular events, mortality, and prostaglandin E2 production by nitrate-induced tolerant rats with acute myocardial infarction. Nitrates 129-136 calcitonin-related polypeptide alpha Rattus norvegicus 10-41 26732494-0 2016 Arabidopsis NRT1.5 Mediates the Suppression of Nitrate Starvation-Induced Leaf Senescence by Modulating Foliar Potassium Level. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 12-16 26958096-16 2016 CONCLUSIONS: CGRP could be involved in the mechanism of nitrate tolerance via the inhibition of release of the potent vasodilator CGRP leading to exacerbation of acute myocardial ischemia. Nitrates 56-63 calcitonin-related polypeptide alpha Rattus norvegicus 13-17 26958096-16 2016 CONCLUSIONS: CGRP could be involved in the mechanism of nitrate tolerance via the inhibition of release of the potent vasodilator CGRP leading to exacerbation of acute myocardial ischemia. Nitrates 56-63 calcitonin-related polypeptide alpha Rattus norvegicus 130-134 26877080-3 2016 Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake. Nitrates 219-226 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 40-50 26877080-3 2016 Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake. Nitrates 219-226 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 52-55 26877080-3 2016 Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake. Nitrates 219-226 basic leucine-zipper 8 Arabidopsis thaliana 60-64 26877080-4 2016 Shoot-derived HY5 auto-activates root HY5 and also promotes root nitrate uptake by activating NRT2.1, a gene encoding a high-affinity nitrate transporter [4]. Nitrates 65-72 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 14-17 26877080-4 2016 Shoot-derived HY5 auto-activates root HY5 and also promotes root nitrate uptake by activating NRT2.1, a gene encoding a high-affinity nitrate transporter [4]. Nitrates 65-72 nitrate transporter 2:1 Arabidopsis thaliana 94-100 26877080-5 2016 In the shoot, HY5 promotes carbon assimilation and translocation, whereas in the root, HY5 activation of NRT2.1 expression and nitrate uptake is potentiated by increased carbon photoassimilate (sucrose) levels. Nitrates 127-134 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 87-90 26732494-3 2016 Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5. Nitrates 44-51 nitrate transporter 1.1 Arabidopsis thaliana 116-120 26732494-3 2016 Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5. Nitrates 44-51 nitrate transporter 1.1 Arabidopsis thaliana 253-257 26732494-3 2016 Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5. Nitrates 193-200 nitrate transporter 1.1 Arabidopsis thaliana 116-120 26732494-3 2016 Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5. Nitrates 193-200 nitrate transporter 1.1 Arabidopsis thaliana 253-257 26732494-5 2016 Further analyses using nrt1.5 single and nia1 nia2 nrt1.5-4 triple mutant showed a negative correlation between nitrate concentration and senescence rate in leaves. Nitrates 112-119 nitrate transporter 1.1 Arabidopsis thaliana 23-27 26732494-5 2016 Further analyses using nrt1.5 single and nia1 nia2 nrt1.5-4 triple mutant showed a negative correlation between nitrate concentration and senescence rate in leaves. Nitrates 112-119 nitrate transporter 1.1 Arabidopsis thaliana 51-55 26732494-6 2016 Moreover, when exposed to nitrate starvation, foliar potassium level decreased in nrt1.5, but adding potassium could essentially restore the early leaf senescence phenotype of nrt1.5 plants. Nitrates 26-33 nitrate transporter 1.1 Arabidopsis thaliana 82-86 26732494-7 2016 Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5. Nitrates 0-7 high affinity K+ transporter 5 Arabidopsis thaliana 56-60 26732494-7 2016 Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5. Nitrates 0-7 annexin 1 Arabidopsis thaliana 75-79 26732494-7 2016 Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 83-87 26732494-7 2016 Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 153-157 26732494-8 2016 These data suggest that NRT1.5 likely perceives nitrate starvation-derived signals to prevent leaf senescence by facilitating foliar potassium accumulation. Nitrates 48-55 nitrate transporter 1.1 Arabidopsis thaliana 24-28 26729042-5 2016 Using the nitrate/nitrite assay, we also demonstrated that the thrombin- and TFLLR-induced production of nitric oxide was inhibited by SCH and L-NAME, a NOS inhibitor. Nitrates 10-17 coagulation factor II, thrombin Homo sapiens 63-71 26545889-4 2016 After domestication of the bacteria, nitrate (50 mg NO3 (-)-N L(-1)) was completely removed within 3 days in the combined tourmaline-bacteria system, and the generated nitrite was also removed within 8 days. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 52-55 26813102-7 2016 Skeletal muscle biopsies from humans with metabolic syndrome after 12 weeks of oral sodium nitrite and nitrate treatment (IND#115926) displayed increased activation of SIRT3 and AMP-activated protein kinase. Nitrates 103-110 sirtuin 3 Homo sapiens 168-173 26887919-5 2016 Nitrate treatment increased ABA levels in root tips; this stimulation requires the activity of the endoplasmic reticulum-localized, ABA-GE-deconjugating enzyme b-GLUCOSIDASE1, but not de novo ABA biosynthesis. Nitrates 0-7 glucosidase 1 Arabidopsis thaliana 162-174 30263239-1 2016 Beetroot is a vegetable rich in nitrate (NO3 -), antioxidants and phenolic compounds that are related to improvements in cardiovascular function and exercise performance. Nitrates 32-39 NBL1, DAN family BMP antagonist Homo sapiens 41-44 26904077-3 2016 The reduced nitrate content of Arabidopsis clce mutants suggested a role in regulation of plant nitrate homeostasis. Nitrates 12-19 chloride channel E Arabidopsis thaliana 43-47 26904077-3 2016 The reduced nitrate content of Arabidopsis clce mutants suggested a role in regulation of plant nitrate homeostasis. Nitrates 96-103 chloride channel E Arabidopsis thaliana 43-47 26564204-2 2016 Bradyrhizobium japonicum, the symbiont of soybeans, can denitrify and grow under free-living conditions with nitrate (NO3 (-)) or nitrite (NO2 (-)) as sole nitrogen source. Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 118-121 26724532-3 2016 AIMS: Study prolonged nitrate supplementation on atherogenesis, hypoxia and inflammation in low density lipoprotein receptor knockout mice (LDLr(-/-)). Nitrates 22-29 low density lipoprotein receptor Mus musculus 92-124 26614506-1 2016 PURPOSE: This study tested the hypothesis that nitrate (NO3-) supplementation would improve performance during high-intensity intermittent exercise featuring different work and recovery intervals. Nitrates 47-54 NBL1, DAN family BMP antagonist Homo sapiens 56-59 26610295-4 2016 In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome. Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 63-66 26610295-4 2016 In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome. Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 135-138 26493186-9 2016 COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients. Nitrates 86-94 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-5 26493186-9 2016 COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients. Nitrates 86-94 peroxisome proliferator activated receptor gamma Homo sapiens 10-20 26969547-4 2016 The content of SNA (the sum of sulfate, nitrate, ammonium, SNA) in PM2.5 in Yuzhong County was generally lower than that at other sites in all seasons. Nitrates 40-47 snail family transcriptional repressor 1 Homo sapiens 15-18 27209746-11 2016 The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water. Nitrates 15-22 immunoglobulin kappa variable 1-16 Homo sapiens 142-145 27209746-11 2016 The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water. Nitrates 100-107 immunoglobulin kappa variable 1-16 Homo sapiens 142-145 27209746-11 2016 The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water. Nitrates 100-107 immunoglobulin kappa variable 1-16 Homo sapiens 142-145 26608644-1 2016 CO2 elevation often alters the plant"s nitrate reductase (NR) activity, the first enzyme acting in the nitrate assimilation pathway. Nitrates 39-46 nitrate reductase 1 Arabidopsis thaliana 58-60 26608644-5 2016 In response to CO2 elevation, NR activity increased in low-nitrate Col-0 plants but was inhibited in high-nitrate Col-0 plants. Nitrates 59-66 nitrate reductase 1 Arabidopsis thaliana 30-32 26608644-5 2016 In response to CO2 elevation, NR activity increased in low-nitrate Col-0 plants but was inhibited in high-nitrate Col-0 plants. Nitrates 106-113 nitrate reductase 1 Arabidopsis thaliana 30-32 26608644-8 2016 Considering all of these findings, this study concluded that, in response to CO2 elevation, either the NR activity induction in low-nitrate plants or the NR activity inhibition in high-nitrate plants is regulated by NOS-generated NO. Nitrates 132-139 nitrate reductase 1 Arabidopsis thaliana 103-105 26608644-8 2016 Considering all of these findings, this study concluded that, in response to CO2 elevation, either the NR activity induction in low-nitrate plants or the NR activity inhibition in high-nitrate plants is regulated by NOS-generated NO. Nitrates 185-192 nitrate reductase 1 Arabidopsis thaliana 154-156 26481009-5 2016 Additionally, we found that OsSLAC1 is a nitrate-selective anion channel without obvious permeability to chloride, malate, and sulfate, and the expression of OsSLAC1 in Arabidopsis slac1-3 (atslac1-3) mutant successfully rescued the hypersensitive phenotype of this mutant to drought stress. Nitrates 41-48 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 181-186 26627858-0 2016 Feeding nitrate and docosahexaenoic acid affects enteric methane production and milk fatty acid composition in lactating dairy cows. Nitrates 8-15 Weaning weight-maternal milk Bos taurus 80-84 26627858-14 2016 Milk protein concentration was lower for nitrate-fed cows. Nitrates 41-48 Weaning weight-maternal milk Bos taurus 0-4 26481009-6 2016 Together, this research suggests that OsSAPK8 is a counterpart of AtOST1 for the activation of OsSLAC1, which is a nitrate-selective anion channel. Nitrates 115-122 Protein kinase superfamily protein Arabidopsis thaliana 66-72 26662603-5 2016 RNA silencing of four of these glutaredoxin genes (AtGRXS3/4/5/8) resulted in plants with increased primary root length (approximately 25% longer than the wild type) and decreased sensitivity to nitrate-mediated inhibition of primary root growth. Nitrates 195-202 CAX-interacting protein 2 Arabidopsis thaliana 31-43 26662603-7 2016 We determined that nitrate induction of glutaredoxin gene expression was dependent upon cytokinin signaling and that cytokinins could activate glutaredoxin gene expression independent of plant nitrate status. Nitrates 19-26 CAX-interacting protein 2 Arabidopsis thaliana 40-52 26435258-3 2016 The aim of the study was to measure and correlate plasma nitrite/nitrate levels with tissue specific expression of iNOS mRNA among women with different grades of cervical lesions and cervical cancer. Nitrates 65-72 nitric oxide synthase 2 Homo sapiens 115-119 26744214-3 2016 The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). Nitrates 4-11 nitrate transporter 1.1 Arabidopsis thaliana 128-134 26744214-3 2016 The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). Nitrates 4-11 nitrate transporter 1.1 Arabidopsis thaliana 148-154 26744214-3 2016 The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). Nitrates 4-11 NITRATE TRANSPORTER 1.8 Arabidopsis thaliana 217-223 26744214-3 2016 The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). Nitrates 4-11 NITRATE TRANSPORTER 1.8 Arabidopsis thaliana 237-243 26744214-4 2016 Genetic and molecular data suggest that NRG2 functions upstream of NRT1.1 in nitrate signaling. Nitrates 77-84 nitrate transporter 1.1 Arabidopsis thaliana 67-73 26744214-5 2016 Furthermore, NRG2 directly interacts with the nitrate regulator NLP7 in the nucleus, but nuclear retention of NLP7 in response to nitrate is not dependent on NRG2. Nitrates 46-53 NIN like protein 7 Arabidopsis thaliana 64-68 26744214-5 2016 Furthermore, NRG2 directly interacts with the nitrate regulator NLP7 in the nucleus, but nuclear retention of NLP7 in response to nitrate is not dependent on NRG2. Nitrates 130-137 NIN like protein 7 Arabidopsis thaliana 110-114 26744214-8 2016 Thus, NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction. Nitrates 31-38 nitrate transporter 1.1 Arabidopsis thaliana 77-81 26437351-1 2016 Nitrate (NO3) is one of the most common contaminants in aquatic environments and groundwater. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 26631727-1 2016 Nitrate (NO3(-)) and nitrite (NO2(-)) are the physiological sources of nitric oxide (NO), a key biological messenger molecule. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 26834770-8 2015 Transcriptional analysis of ZmXET1 confirmed the stimulatory effect of nitrate on XGs accumulation in cells of the TZ. Nitrates 71-78 xyloglucan endotransglycosylase homolog 1 Zea mays 28-34 26607938-8 2016 Dietary nitrate also caused a small but significant reduction (7.6%) in platelet-monocyte aggregates compared with an increase of 10.1% in the placebo group (P = 0.004), with statistically significant reductions in stimulated (ex vivo) P-selectin expression compared with the placebo group (P < 0.05) but no significant changes in unstimulated expression. Nitrates 8-15 selectin P Homo sapiens 236-246 26547269-4 2016 The denitrification rates using optimal carbon-to-nitrate ratios of acidogenic liquid were more than 25 mg NO3-N/(gVSS h). Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 107-110 27526131-5 2016 Acidotic conditions for up to 6 h increased the iNOS expression significantly which was functional as indicated by an elevated level of nitrate/nitrite formation by 30 %. Nitrates 136-143 nitric oxide synthase 2, inducible Mus musculus 48-52 27458036-6 2016 XOR has an activating role that is essential to the pharmacological action of quinone drugs, cyadox, antiviral nucleoside analogues, allopurinol, nitrate and nitrite. Nitrates 146-153 xanthine dehydrogenase Homo sapiens 0-3 26335529-7 2016 The results of an ANOVA and response surface analysis showed that HRT, influent NO3 (-)-N concentration, influent CODCr concentration, and the interaction between the HRT and influent CODCr concentration significantly affected the nitrate removal efficiency (P < 0.05). Nitrates 231-238 NBL1, DAN family BMP antagonist Homo sapiens 80-83 26681182-7 2016 Dissolved inorganic nitrogen (DIN) in S2 mainly comprised ammonium (NH4 (+)), while nitrate (NO3 (-)) predominated in S1. Nitrates 84-91 NBL1, DAN family BMP antagonist Homo sapiens 93-96 25811939-10 2016 Spring water sections within the high mountains contain nitrate in low concentrations with low delta(15)NNO3 values of -3 % and high delta(18)ONO3 values up to 13 %. Nitrates 56-63 NNO3 Homo sapiens 104-108 26074023-5 2016 Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Nitrates 62-69 superoxide dismutase 3 Homo sapiens 170-176 26074023-5 2016 Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1. Nitrates 62-69 glutathione peroxidase 1 Homo sapiens 181-185 25811939-11 2016 High mountain stream water sub-catchments dominated by nearly undisturbed forest and grassland contribute nitrate with delta(15)NNO3 and delta(18)ONO3 values of -1 and -3.5 %, respectively. Nitrates 106-113 NNO3 Homo sapiens 128-132 25923308-2 2016 In this study, we report the assimilation and utilization of nitrate luxuriant levels, 20 times more than the highest N fertilizer application in Europe, by transgenic poplars overexpressing a cytosolic glutamine synthetase (GS1). Nitrates 61-68 pseudouridine 5'-phosphatase Homo sapiens 225-228 27018849-5 2016 Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. Nitrates 14-21 pyridoxin (pyrodoxamine) 5'-phosphate oxidase Arabidopsis thaliana 60-64 27049601-0 2016 The AtGRXS3/4/5/7/8 glutaredoxin gene cluster on Arabidopsis thaliana chromosome 4 is coordinately regulated by nitrate and appears to control primary root growth. Nitrates 112-119 CAX-interacting protein 2 Arabidopsis thaliana 20-32 27049601-2 2016 We previously identified a group of class III glutaredoxin genes whose expression is strongly upregulated by nitrate, but not ammonium, in Arabidopsis thaliana shoots and roots. Nitrates 109-116 CAX-interacting protein 2 Arabidopsis thaliana 46-58 27049601-5 2016 Interestingly, there is one additional glutaredoxin, AtGRXS7, in this same gene cluster, but this gene was not identified as nitrate-responsive in our previous studies. Nitrates 125-132 CAX-interacting protein 2 Arabidopsis thaliana 39-51 26562799-7 2016 Stable isotope data reveal nutrient inputs to the river upstream of the waste water treatment works that are consistent with partially denitrified sewage or livestock sources of nitrate (delta(15)NNO3 range = +11.5 to +13.1%) and with agricultural sources of phosphate (delta(18)OPO4 range = +16.6 to +19.0%). Nitrates 178-185 NNO3 Homo sapiens 196-200 27717924-10 2016 CONCLUSIONS: the combined effect of nitrate and sodium fluoride for 30 days leads to disregulatory increased activity of NO-synthase enzymes and reduction of arginase pathway of L-arginine in the soft tissues of parodontium that is promoted by hyperactivation of iNOS and NF-kappaB, and increased peroxynitrite production. Nitrates 36-43 nitric oxide synthase 2 Rattus norvegicus 263-267 27508376-5 2016 Ammonium removal rate was up to 95% in biofilters with or without electrolysis integration with an influent ammonium concentration of 40 mg/L, and the accumulation of nitrate and nitrite was much lower in the effluent of E-BF than that of BF. Nitrates 167-174 EBF transcription factor 1 Homo sapiens 221-225 26577172-4 2015 The nitrate salts fall into three groups based on their observed rate of NO2 formation (R(NO2)): (1) RbNO3 and KNO3, which readily produce NO2 (R(NO2) > 3 ppb min(-1)), (2) Ca(NO3)2, which produces NO2 more slowly (R(NO2) < 1 ppb min(-1)), and (3) Mg(NO3)2 and NaNO3, which lie between the other two groups. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 103-106 28478405-10 2016 CONCLUSIONS: the combined effect of nitrate and sodium fluoride for 30 days leads to disregulatory increased activity of NO-synthase enzymes and reduction of arginase pathway of L-arginine in the soft tissues of parodontium that is promoted by hyperactivation of iNOS and NF-kappaB, and increased peroxynitrite production. Nitrates 36-43 nitric oxide synthase 2 Rattus norvegicus 263-267 26577172-4 2015 The nitrate salts fall into three groups based on their observed rate of NO2 formation (R(NO2)): (1) RbNO3 and KNO3, which readily produce NO2 (R(NO2) > 3 ppb min(-1)), (2) Ca(NO3)2, which produces NO2 more slowly (R(NO2) < 1 ppb min(-1)), and (3) Mg(NO3)2 and NaNO3, which lie between the other two groups. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 112-115 26694920-0 2015 Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism. Nitrates 0-7 peroxisome proliferator activated receptor alpha Mus musculus 78-82 26694920-6 2015 We show that nitrate induces FA oxidation through a soluble guanylate cyclase (sGC)/cGMP-mediated PPARbeta/delta- and PPARalpha-dependent mechanism. Nitrates 13-20 peroxisome proliferator activated receptor alpha Mus musculus 84-127 26549233-0 2015 The calcium sensor CBL7 modulates plant responses to low nitrate in Arabidopsis. Nitrates 57-64 calcineurin B-like protein 7 Arabidopsis thaliana 19-23 26733879-3 2015 Interestingly, the first cloned nitrate transporter in Arabidopsis, NRT1.1 functions as a dual-affinity transporter, which can change its affinity for nitrate in response to substrate availability. Nitrates 32-39 nitrate transporter 1.1 Arabidopsis thaliana 68-74 26549233-4 2015 Here, we report that CBL7 is involved in the regulation of low-nitrate response in Arabidopsis. Nitrates 63-70 calcineurin B-like protein 7 Arabidopsis thaliana 21-25 26549233-5 2015 Expression of CBL7 was predominant in the root of young seedlings and substantially induced by nitrate starvation. Nitrates 95-102 calcineurin B-like protein 7 Arabidopsis thaliana 14-18 26549233-6 2015 Cbl7 mutant was more inhibited in root growth upon nitrate starvation compared to the wild-type. Nitrates 51-58 calcineurin B-like protein 7 Arabidopsis thaliana 0-4 26549233-7 2015 Interestingly, the growth arrest of cbl7 under low-nitrate conditions relied on acidic pH. Nitrates 51-58 calcineurin B-like protein 7 Arabidopsis thaliana 36-40 26549233-9 2015 Accordingly, the cbl7 mutant plants retained lower nitrate content than wild-type plants under low-nitrate condition. Nitrates 51-58 calcineurin B-like protein 7 Arabidopsis thaliana 17-21 26549233-9 2015 Accordingly, the cbl7 mutant plants retained lower nitrate content than wild-type plants under low-nitrate condition. Nitrates 99-106 calcineurin B-like protein 7 Arabidopsis thaliana 17-21 26549233-10 2015 Taken together, our results uncover a novel role of CBL7 in the response to nitrate deficiency in Arabidopsis. Nitrates 76-83 calcineurin B-like protein 7 Arabidopsis thaliana 52-56 26338830-1 2015 PURPOSE: Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 26815943-8 2015 The results showed that the nitrate (NO3-), NO2-, TSS, turbidity and total phosphorous (TP) levels were related to the soil type, and the parameters DO, electrical conductivity (EC), ammoniacal nitrogen (N-NH3) and thermotolerant coliforms (TC) were related to organic matter pollution, with the P5 sampling site being the most critical site. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 37-40 26385079-1 2015 A gap in our understanding of the beneficial systemic responses to dietary constituents nitrate (NO3(-)), nitrite (NO2(-)) and conjugated linoleic acid (cLA) is the identification of the downstream metabolites that mediate their actions. Nitrates 88-95 NBL1, DAN family BMP antagonist Homo sapiens 97-100 26297074-3 2015 We hypothesized that (H1) soil nitrate (NO3 (-) ) is elevated nearer to the urban core, reflecting N deposition gradients. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 40-43 26508776-0 2015 Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 56-76 26346778-0 2015 G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana. Nitrates 49-56 G protein alpha subunit 1 Arabidopsis thaliana 0-23 26346778-0 2015 G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana. Nitrates 49-56 G protein alpha subunit 1 Arabidopsis thaliana 25-29 26346778-4 2015 We found 394 GPA1-regulated genes spanning 79 biological processes, including biotic and abiotic stresses, development, flavonoid biosynthesis, transcription factors, transporters and nitrate/phosphate responses. Nitrates 184-191 G protein alpha subunit 1 Arabidopsis thaliana 13-17 26508776-0 2015 Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 118-122 26508776-0 2015 Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis. Nitrates 0-7 STELAR K+ outward rectifier Arabidopsis thaliana 161-165 26605044-2 2015 In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds. Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 86-89 26094110-3 2015 Nitrate (NO3) concentrations in runoff from semi-natural catchments typically show an annual cycle, with low concentrations during the summer and high concentrations during the winter. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 26364226-2 2015 The nitrate removal rates obtained in the methanol- and ethanol-fed mixotrophic denitrifying AnFB-MBRs reached 1.44-3.84 g NO3 -N/L reactor d at a hydraulic retention time of 0.5 h, which were significantly superior to those reported in packed bed reactors. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 123-126 26635847-3 2015 A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport. Nitrates 52-59 nitrate transporter 1.1 Arabidopsis thaliana 134-140 26635847-3 2015 A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport. Nitrates 144-151 nitrate transporter 1.1 Arabidopsis thaliana 134-140 26635847-3 2015 A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport. Nitrates 144-151 nitrate transporter 1.1 Arabidopsis thaliana 134-140 26151563-7 2015 After adjustment for multiple comparisons using an overall 0.05 level of type I error, the distribution of nitrate penetration values was found to differ significantly among all groups with the exception of DayWhite (median: 10.72 muM) and UltraEZ (median: 9.22 muM), which differed significantly from other groups but not from each other. Nitrates 107-114 latexin Homo sapiens 262-265 26325324-1 2015 INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 31-34 26325324-1 2015 INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 135-138 26151563-8 2015 The highest levels of nitrate penetration value were observed for PreviDent (median: 27.61 muM) followed by Relief ACP (median: 19.64 muM). Nitrates 22-29 latexin Homo sapiens 91-94 26151563-8 2015 The highest levels of nitrate penetration value were observed for PreviDent (median: 27.61 muM) followed by Relief ACP (median: 19.64 muM). Nitrates 22-29 latexin Homo sapiens 134-137 26371233-0 2015 The Nitrate-Inducible NAC Transcription Factor TaNAC2-5A Controls Nitrate Response and Increases Wheat Yield. Nitrates 4-11 NAC domain-containing protein 2 Triticum aestivum 47-53 26310141-3 2015 Here we report the differential regulation of expression of POLYAMINE OXIDASE2 of Arabidopsis (AtPAO2) in interaction with ABA, nitrate and ammonium. Nitrates 128-135 polyamine oxidase 2 Arabidopsis thaliana 60-78 26310141-3 2015 Here we report the differential regulation of expression of POLYAMINE OXIDASE2 of Arabidopsis (AtPAO2) in interaction with ABA, nitrate and ammonium. Nitrates 128-135 polyamine oxidase 2 Arabidopsis thaliana 95-101 26371233-0 2015 The Nitrate-Inducible NAC Transcription Factor TaNAC2-5A Controls Nitrate Response and Increases Wheat Yield. Nitrates 66-73 NAC domain-containing protein 2 Triticum aestivum 47-53 26371233-3 2015 Here, we isolated a nitrate-inducible and cereal-specific NAM, ATAF, and CUC (NAC) transcription factor, TaNAC2-5A, from wheat (Triticum aestivum). Nitrates 20-27 NAC domain-containing protein 2 Triticum aestivum 105-111 26371233-5 2015 Overexpression of TaNAC2-5A in wheat enhanced root growth and nitrate influx rate and, hence, increased the root"s ability to acquire nitrogen. Nitrates 62-69 NAC domain-containing protein 2 Triticum aestivum 18-24 26371233-7 2015 These results suggest that TaNAC2-5A is involved in nitrate signaling and show that it is an exciting gene resource for breeding crops with more efficient use of fertilizer. Nitrates 52-59 NAC domain-containing protein 2 Triticum aestivum 27-33 26276822-2 2015 In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Nitrates 192-199 nitric oxide synthase 3, endothelial cell Mus musculus 85-118 26412597-2 2015 A sampling of structures in which the nitrate ion is solvated by 32 water molecules is optimized using second order Moller-Plesset perturbation theory (MP2). Nitrates 38-45 tryptase pseudogene 1 Homo sapiens 152-155 26276822-2 2015 In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis. Nitrates 192-199 nitric oxide synthase 3, endothelial cell Mus musculus 120-124 26335797-0 2015 Interaction of Yna1 and Yna2 Is Required for Nuclear Accumulation and Transcriptional Activation of the Nitrate Assimilation Pathway in the Yeast Hansenula polymorpha. Nitrates 104-111 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 15-19 26231655-6 2015 Nitrate concentrations declined from a high of 25 muM upgradient and adjacent to the barrier to <0.1 muM within the PRB. Nitrates 0-7 RB transcriptional corepressor 1 Homo sapiens 119-122 26304850-10 2015 Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes. Nitrates 127-134 nitrate transporter 1.1 Arabidopsis thaliana 34-38 26304850-10 2015 Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes. Nitrates 127-134 nitrate transporter 1.1 Arabidopsis thaliana 41-49 26304850-10 2015 Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes. Nitrates 186-193 nitrate transporter 1.1 Arabidopsis thaliana 34-38 26304850-10 2015 Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes. Nitrates 186-193 nitrate transporter 1.1 Arabidopsis thaliana 41-49 26335797-2 2015 The genes necessary for nitrate assimilation are organised in this organism as a cluster comprising those encoding nitrate reductase (YNR1), nitrite reductase (YNI1), a high affinity transporter (YNT1), as well as the two pathway specific Zn(II)2Cys2 transcriptional activators (YNA1, YNA2). Nitrates 24-31 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 279-283 26335797-4 2015 Yna1p activates YNA2 as well as its own (YNA1) transcription thus forming a nitrate-dependent autoactivation loop. Nitrates 76-83 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 41-45 26084693-1 2015 While acute treatment with beetroot juice (BRJ) containing nitrate (NO3 (-)) can lower systolic blood pressure (SBP), afterload, and myocardial O2 demand during submaximal exercise, effects of chronic supplementation with BRJ (containing a relatively low dose of NO3 (-), 400 mg) on cardiac output (CO), SBP, total peripheral resistance (TPR), and the work of the heart in response to dynamic exercise are not known. Nitrates 59-66 NBL1, DAN family BMP antagonist Homo sapiens 68-71 25846114-1 2015 UNLABELLED: It is possible that dietary nitrate (NO3 (-)) supplementation may improve both physical and cognitive performance via its influence on blood flow and cellular energetics. Nitrates 40-47 NBL1, DAN family BMP antagonist Homo sapiens 49-52 25324021-5 2015 The crop field was responsible for 96% of the total nitrate loading (16.2 t NO3 /year) to the lake even though the field only covered 4.5% of the catchment area. Nitrates 52-59 NBL1, DAN family BMP antagonist Homo sapiens 76-79 25943519-1 2015 A laboratory column experiment was conducted to test the efficiency of denitrifying bioreactors for the nitrate (NO3-N) removal in drainage waters at different flow rates and after desiccation. Nitrates 104-111 NBL1, DAN family BMP antagonist Homo sapiens 113-116 26300787-0 2015 In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver. Nitrates 58-65 adenosine A2b receptor Mus musculus 13-16 26008190-8 2015 The nitrate sensitivity was reduced at mM concentrations in a loss-of-function mutant of the nitrate transporter and sensor gene NRT1;1 (NPF6.3). Nitrates 4-11 nitrate transporter 1.1 Arabidopsis thaliana 129-133 26347655-7 2015 It is proposed that CuB delivers superoxide to NO bound to Fe-heme forming peroxynitrite, then nitrate that diffuses away. Nitrates 95-102 rhomboid 5 homolog 2 Mus musculus 20-23 26258667-2 2015 ANR1 was reported to play a key role in controlling lateral root development through nitrate signal in Arabidopsis. Nitrates 85-92 AGAMOUS-like 44 Arabidopsis thaliana 0-4 24224525-1 2015 AIMS: Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO synthase (NOS)-dependent pathway. Nitrates 16-23 nitric oxide synthase 1, neuronal Mus musculus 181-192 25474587-0 2015 A 150 kDa plasma membrane complex of AtNRT2.5 and AtNAR2.1 is the major contributor to constitutive high-affinity nitrate influx in Arabidopsis thaliana. Nitrates 114-121 nitrate transporter2.5 Arabidopsis thaliana 37-45 25937621-1 2015 It is now recognised that administration of oral nitrate (NO3(-)), in its various forms, increases the level of nitric oxide (NO) metabolites in the circulation of humans. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 58-61 26321266-3 2015 Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means. Nitrates 316-323 xanthine dehydrogenase Homo sapiens 182-185 26068891-9 2015 Nitrate supplementation was associated with improved insulin response, decreased plasma IL-10 and a trend towards improved survival. Nitrates 0-7 interleukin 10 Mus musculus 88-93 26163808-3 2015 LPS-stimulated iNOS and NADPH oxidase (Nox) activity in RAW 264.7 murine macrophages was assessed by measuring cellular nitrate and superoxide ( [Formula: see text] ) production, respectively. Nitrates 120-127 nitric oxide synthase 2, inducible Mus musculus 15-19 26163808-4 2015 The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent. Nitrates 23-30 toll-like receptor 4 Mus musculus 92-96 26163808-4 2015 The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent. Nitrates 23-30 nitric oxide synthase 2, inducible Mus musculus 139-143 26163808-4 2015 The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent. Nitrates 23-30 toll-like receptor 4 Mus musculus 155-159 25474587-4 2015 We demonstrate that AtNRT2.5 is predominantly expressed in roots of nitrate-deprived WT plants as a 150 kDa molecular complex with AtNAR2.1. Nitrates 68-75 nitrate transporter2.5 Arabidopsis thaliana 20-28 25474587-6 2015 The remaining cHATS nitrate influx in these mutants is due to a residual contribution by the inducible high-affinity transporter encoded by AtNRT2.1/AtNAR2.1. Nitrates 20-27 nitrate transporter 2:1 Arabidopsis thaliana 140-148 25474587-7 2015 Estimates of the kinetic properties of the NRT2.5 transporter reveal that its low Km for nitrate makes this transporter ideally suited to detect and respond to trace quantities of nitrate in the root environment. Nitrates 89-96 nitrate transporter 2:1 Arabidopsis thaliana 43-47 25474587-7 2015 Estimates of the kinetic properties of the NRT2.5 transporter reveal that its low Km for nitrate makes this transporter ideally suited to detect and respond to trace quantities of nitrate in the root environment. Nitrates 180-187 nitrate transporter 2:1 Arabidopsis thaliana 43-47 26197322-2 2015 This paper describes a low-cost, compact, and scalable nitrate sensor based on electrochemical impedance spectroscopy for monitoring trace amounts of NO3- in selected growing media. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 150-153 25869522-0 2015 Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats. Nitrates 93-100 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 10-34 25869522-7 2015 sGC activator therapy improves partially the adverse effects of nitroglycerin therapy whereas sGC stimulation has only minor beneficial effects pointing to a nitroglycerin-dependent sGC oxidation/inactivation mechanism contributing to nitrate tolerance. Nitrates 235-242 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 0-3 26151723-1 2015 We present a novel approach for nitrogen (delta(15)N) and oxygen (delta(18)O) isotopic analysis of nitrate in water based on the isotopic analysis of N2O produced from the conversion of NO3(-) by cultured denitrifying bacteria and off-axis integrated cavity output spectroscopy (OA-ICOS). Nitrates 99-106 inducible T cell costimulator Homo sapiens 282-286 26151723-3 2015 Sample analysis time was ~300 s. The use of OA-ICOS technology yields accurate and precise delta(15)N and delta(18)O results for dissolved nitrate samples when nonlinearity issues are considered. Nitrates 139-146 inducible T cell costimulator Homo sapiens 47-51 25902041-4 2015 Data from 832 human subjects revealed that heterozygous and homozygous Arg972 IRS-1 carriers had significantly lower levels of plasma eNOS and nitrite/nitrate than the homozygous wild-type (WT) IRS-1 carriers. Nitrates 151-158 insulin receptor substrate 1 Homo sapiens 78-83 25940469-1 2015 Nitrate (NO3(-)) contamination of freshwater is considered one of the most prevalent global environmental problems. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 25902041-9 2015 On the whole, our in vivo data demonstrate that Arg972 IRS-1 is associated with decreased plasma eNOS and nitrite/nitrate levels in human subjects. Nitrates 114-121 insulin receptor substrate 1 Homo sapiens 48-60 26057801-2 2015 THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1. Nitrates 70-77 uncharacterized protein Chlamydomonas reinhardtii 0-4 26091235-3 2015 Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. Nitrates 100-107 insulin Homo sapiens 172-179 26057801-2 2015 THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1. Nitrates 70-77 uncharacterized protein Chlamydomonas reinhardtii 40-44 26057801-2 2015 THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1. Nitrates 70-77 uncharacterized protein Chlamydomonas reinhardtii 170-174 26057801-3 2015 In vitro and physiological evidence suggests that THB1 converts the nitric oxide generated by NIT1 into nitrate. Nitrates 104-111 uncharacterized protein Chlamydomonas reinhardtii 50-54 26057801-3 2015 In vitro and physiological evidence suggests that THB1 converts the nitric oxide generated by NIT1 into nitrate. Nitrates 104-111 uncharacterized protein Chlamydomonas reinhardtii 94-98 25700865-1 2015 This work presents a novel electrochemical assay for the collective measurement of nitric oxide (NO) and its metabolites nitrite (NO2(-)) and nitrate (NO3(-)) in volume miniaturized sample at low cost using copper(II) chlorophyllin (CuCP) modified sensor electrode. Nitrates 142-149 NBL1, DAN family BMP antagonist Homo sapiens 151-154 25826741-7 2015 Nitrate supplementation has been shown to increase NO-dependent vasodilatation through both NO synthase (NOS)-dependent and NOS-independent pathways. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 92-103 25694484-6 2015 ANG II also increased renal production of ROS and urinary excretion of thiobarburic acid-reactive substances and reduced the activity of antioxidants and urinary excretion of nitrite/nitrate and the 17beta-estradiol metabolite 2-methoxyestradiol in Cyp1b1(-/-) but not Cyp1b1(+/+) mice. Nitrates 183-190 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-6 24990704-8 2015 The following predictors were found to be associated with EPO prescription: iron supplementation (odds ratio [OR] 52.70, 95% confidence interval [CI] 11.70-237.46), renal clinic appointment (OR 2.60, 95% CI 1.79-3.76), malignancy (OR 1.52, 95% CI 1.07-2.16) and use of hydralazine/nitrates (OR 1.41, 95% CI 1.03-1.92). Nitrates 281-289 erythropoietin Homo sapiens 58-61 25991919-1 2015 BACKGROUND AND AIM: The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recently raised the hypothesis that inorganic nitrate and nitrite could be potential therapeutic agents in type 2 diabetes. Nitrates 45-52 insulin Homo sapiens 190-197 25991919-1 2015 BACKGROUND AND AIM: The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recently raised the hypothesis that inorganic nitrate and nitrite could be potential therapeutic agents in type 2 diabetes. Nitrates 268-275 insulin Homo sapiens 190-197 25661464-0 2015 [Nitrate concentrations in tap water in Spain]. Nitrates 1-8 nuclear RNA export factor 1 Homo sapiens 27-30 25943353-0 2015 Nitrate sensing and uptake in Arabidopsis are enhanced by ABI2, a phosphatase inactivated by the stress hormone abscisic acid. Nitrates 0-7 Protein phosphatase 2C family protein Arabidopsis thaliana 58-62 25943353-4 2015 NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana. Nitrates 52-59 nitrate transporter 1.1 Arabidopsis thaliana 22-28 25943353-4 2015 NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 22-28 25943353-4 2015 NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana. Nitrates 166-173 CBL-interacting protein kinase 23 Arabidopsis thaliana 95-101 25943353-4 2015 NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana. Nitrates 166-173 calcineurin B-like protein 9 Arabidopsis thaliana 126-130 25943353-5 2015 We identified two additional components that regulate nitrate transport, sensing, and signaling: the calcium sensor CBL1 and protein phosphatase 2C family member ABI2, which is inhibited by the stress-response hormone abscisic acid. Nitrates 54-61 calcineurin B-like protein 1 Arabidopsis thaliana 116-120 25943353-5 2015 We identified two additional components that regulate nitrate transport, sensing, and signaling: the calcium sensor CBL1 and protein phosphatase 2C family member ABI2, which is inhibited by the stress-response hormone abscisic acid. Nitrates 54-61 Protein phosphatase 2C family protein Arabidopsis thaliana 162-166 25943353-7 2015 Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling. Nitrates 127-134 abl-interactor 2 S homeolog Xenopus laevis 76-80 25943353-7 2015 Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling. Nitrates 127-134 abl-interactor 2 S homeolog Xenopus laevis 96-100 25943353-7 2015 Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling. Nitrates 146-153 abl-interactor 2 S homeolog Xenopus laevis 96-100 25943353-7 2015 Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling. Nitrates 146-153 abl-interactor 2 S homeolog Xenopus laevis 96-100 25943353-8 2015 These findings suggest that ABI2 may functionally link stress-regulated control of growth and nitrate uptake and utilization, which are energy-expensive processes. Nitrates 94-101 Protein phosphatase 2C family protein Arabidopsis thaliana 28-32 25727730-9 2015 Nitrate levels in skeletal muscle and blood in nNOS(-/-) mice were dramatically lower when compared with controls, which support further our hypothesis. Nitrates 0-7 nitric oxide synthase 1, neuronal Mus musculus 47-51 25917853-9 2015 CONCLUSIONS: Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates. Nitrates 167-175 nitric oxide synthase 3 Homo sapiens 50-54 25819437-0 2015 LeNRT2.3 functions in nitrate acquisition and long-distance transport in tomato. Nitrates 22-29 nitrate transporter NRT2.3 Solanum lycopersicum 0-8 25819437-3 2015 In this study, we report the functions of LeNRT2.3 in nitrate transport in tomato. Nitrates 54-61 nitrate transporter NRT2.3 Solanum lycopersicum 42-50 25819437-4 2015 Our results show that LeNRT2.3 is induced by nitrate, and mainly localizes to the plasma membranes of rhizodermal and pericycle cells in roots. Nitrates 45-52 nitrate transporter NRT2.3 Solanum lycopersicum 22-30 25819437-5 2015 Further analysis in Xenopus oocytes showed that LeNRT2.3 mediates low-affinity nitrate transport. Nitrates 79-86 nitrate transporter NRT2.3 Solanum lycopersicum 48-56 25819437-6 2015 35S:LeNRT2.3 increased nitrate uptake in root and transport from root to shoot. Nitrates 23-30 nitrate transporter NRT2.3 Solanum lycopersicum 4-12 25819437-8 2015 Taken together, these results suggest that LeNRT2.3 plays a double role in nitrate uptake and long-distance transport in tomato. Nitrates 75-82 nitrate transporter NRT2.3 Solanum lycopersicum 43-51 25727730-10 2015 Although the nitrate reductase activity of xanthine oxidoreductase in muscle is less than that of liver, the residual activity in muscle could be very important in view of its total mass and the high basal level of nitrate. Nitrates 13-20 xanthine dehydrogenase Homo sapiens 43-66 25659431-0 2015 Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism. Nitrates 127-134 nitrate/nitrite response transcriptional regulator NarL Mycobacterium tuberculosis H37Rv 57-61 25772087-1 2015 Highly oxidizing nitrate radicals (NO3 ) are easily accessed from readily available nitrate salts by visible light photoredox catalysis using a purely organic dye as the catalyst and oxygen as the terminal oxidant. Nitrates 84-97 NBL1, DAN family BMP antagonist Homo sapiens 35-38 25772087-2 2015 The interaction of the excited catalyst and nitrate anions was studied by spectroscopic methods to elucidate the mechanism, and the method was applied to the NO3 induced oxidation of alkynes and alcohols. Nitrates 44-51 NBL1, DAN family BMP antagonist Homo sapiens 158-161 25849210-1 2015 Ecologists have found a close relationship between the concentrations of nitrate (NO3-) and dissolved organic carbon (DOC) in ecosystems. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 82-85 25303373-8 2015 Furthermore, chronic treatment of these patients with drugs like ACE inhibitors, statins and nitrates may modify signalling, inhibiting the protective effect of postconditioning mimetics, or conversely induce a maximally protected state wherein no further benefit can be demonstrated. Nitrates 93-101 angiotensin I converting enzyme Homo sapiens 65-68 26164890-6 2015 Sulfate mainly existed in fine particle in the forms of (NH4)2SO4 and K2SO4, while nitrate mainly existed in coarse particle in the form of Mg(NO3)2. Nitrates 83-90 NBL1, DAN family BMP antagonist Homo sapiens 143-146 25659431-1 2015 Mycobacterium tuberculosis genes Rv0844c/Rv0845 encoding the NarL response regulator and NarS histidine kinase are hypothesized to constitute a two-component system involved in the regulation of nitrate metabolism. Nitrates 195-202 nitrate/nitrite response transcriptional regulator NarL Mycobacterium tuberculosis H37Rv 61-65 25659431-4 2015 Transcriptional profiling between M. tuberculosis H37Rv and a DeltanarL mutant strain during exponential growth in broth cultures with or without nitrate defined an ~30-gene NarL regulon that exhibited significant overlap with DevR-regulated genes, thereby implicating a role for the DevR response regulator in the regulation of nitrate metabolism. Nitrates 146-153 nitrate/nitrite response transcriptional regulator NarL Mycobacterium tuberculosis H37Rv 174-178 27246882-0 2015 Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1. Nitrates 23-30 nitrate transporter 1.1 Arabidopsis thaliana 74-80 25683572-1 2015 When oxygen is limiting in soils and sediments, microorganisms utilize nitrate (NO3-) in respiration--through the process of denitrification--leading to the production of dinitrogen (N2) gas and trace amounts of nitrous (N2O) and nitric (NO) oxides. Nitrates 71-78 NBL1, DAN family BMP antagonist Homo sapiens 80-83 25695878-8 2015 The computed structure of PuO3(NO3)2(-) is essentially a plutonyl(VI) core, Pu(VI)O2(2+), coordinated in the equatorial plane by two nitrate ligands and one radical oxygen atom. Nitrates 133-140 NBL1, DAN family BMP antagonist Homo sapiens 31-34 27246882-1 2015 In Arabidopsis the plasma membrane nitrate transceptor (transporter/receptor) NRT1.1 governs many physiological and developmental responses to nitrate. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 78-82 27246882-1 2015 In Arabidopsis the plasma membrane nitrate transceptor (transporter/receptor) NRT1.1 governs many physiological and developmental responses to nitrate. Nitrates 143-150 nitrate transporter 1.1 Arabidopsis thaliana 78-82 27246882-2 2015 Alongside facilitating nitrate uptake, NRT1.1 regulates the expression levels of many nitrate assimilation pathway genes, modulates root system architecture, relieves seed dormancy and protects plants from ammonium toxicity. Nitrates 23-30 nitrate transporter 1.1 Arabidopsis thaliana 39-43 27246882-2 2015 Alongside facilitating nitrate uptake, NRT1.1 regulates the expression levels of many nitrate assimilation pathway genes, modulates root system architecture, relieves seed dormancy and protects plants from ammonium toxicity. Nitrates 86-93 nitrate transporter 1.1 Arabidopsis thaliana 39-43 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 100-107 nitrate transporter 1.1 Arabidopsis thaliana 70-74 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 100-107 nitrate transporter 2:1 Arabidopsis thaliana 249-255 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 70-74 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 2:1 Arabidopsis thaliana 249-255 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 70-74 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 2:1 Arabidopsis thaliana 249-255 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 70-74 27246882-4 2015 We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations. Nitrates 166-173 nitrate transporter 2:1 Arabidopsis thaliana 249-255 27246882-7 2015 In particular, we present evidence to suggest that the phosphorylated and non-phosphorylated forms of NRT1.1 at T101 have distinct signalling functions, and that the nitrate-dependent regulation of root development depends on the phosphorylated form. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 102-106 25688692-6 2015 Nitrate reduction activity, the first step in the denitrification process, was recorded for isolates under simulated anoxic, deep-sea conditions showing ecological significance of fungi in the oxygen-depleted habitats. Nitrates 0-7 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 130-133 25343972-2 2015 The AnFB-MBR produced consistent high-quality product water when fed by a synthetic groundwater with NO3 (-)-N ranging 25-80 mg/L and operated at hydraulic retention times of 0.5-5.0 h. A nitrate removal rate of up to 4.0 g NO3 (-)-N/Lreactord was attained by the bioreactor, which exceeded any reported removal capacity. Nitrates 188-195 translocator protein Homo sapiens 9-12 25343972-2 2015 The AnFB-MBR produced consistent high-quality product water when fed by a synthetic groundwater with NO3 (-)-N ranging 25-80 mg/L and operated at hydraulic retention times of 0.5-5.0 h. A nitrate removal rate of up to 4.0 g NO3 (-)-N/Lreactord was attained by the bioreactor, which exceeded any reported removal capacity. Nitrates 188-195 NBL1, DAN family BMP antagonist Homo sapiens 224-227 25422368-5 2015 At higher nitrate doses, however, a partial reversal of this effect occurred; this was accompanied by increased renal erythropoietin expression and stabilization of hypoxia-inducible factors, likely brought about by the relative anemia. Nitrates 10-17 erythropoietin Rattus norvegicus 118-132 25422368-7 2015 Suppression of hepatic erythropoietin expression by nitrate may thus act to decrease blood viscosity while matching oxygen supply to demand, whereas renal oxygen sensing could act as a brake, averting a potentially detrimental fall in hematocrit. Nitrates 52-59 erythropoietin Rattus norvegicus 23-37 24986777-0 2015 A sensitive and stable amperometric nitrate biosensor employing Arabidopsis thaliana nitrate reductase. Nitrates 36-43 nitrate reductase 1 Arabidopsis thaliana 85-102 25764461-8 2015 Redundancy analysis showed that dissolved organic carbon, ammonium (NH4 (+)), ferrous iron (Fe(2+)) and nitrate (NO3 (-)) in pore water explained 33.4% of the variation in soil bacterial community composition, implying that urea regimes influenced the relative abundance of some bacterial populations possibly by regulating soil characteristics and then influencing N2O emission. Nitrates 104-111 NBL1, DAN family BMP antagonist Homo sapiens 113-116 24986777-4 2015 The GC/NR electrode shows a pronounced cathodic wave for nitrate reduction and the catalytic current increases linearly in the nitrate concentration range of 10-400 microM with a correlation coefficient of 0.989. Nitrates 127-134 nitrate reductase 1 Arabidopsis thaliana 7-9 24986777-1 2015 Nitrate reductase (NR) from the plant Arabidopsis thaliana has been employed in the development of an amperometric nitrate biosensor that functions at physiological pH. Nitrates 115-122 nitrate reductase 1 Arabidopsis thaliana 0-17 24986777-1 2015 Nitrate reductase (NR) from the plant Arabidopsis thaliana has been employed in the development of an amperometric nitrate biosensor that functions at physiological pH. Nitrates 115-122 nitrate reductase 1 Arabidopsis thaliana 19-21 24986777-3 2015 Nitrate is enzymatically reduced to nitrite and the oxidized form of NR is electrochemically reduced by the hydroquinone form of the mediator (AQH2). Nitrates 0-7 nitrate reductase 1 Arabidopsis thaliana 69-71 24986777-4 2015 The GC/NR electrode shows a pronounced cathodic wave for nitrate reduction and the catalytic current increases linearly in the nitrate concentration range of 10-400 microM with a correlation coefficient of 0.989. Nitrates 57-64 nitrate reductase 1 Arabidopsis thaliana 7-9 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 56-63 nitrate transport 2 Zea mays 132-136 25554360-1 2015 Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. Nitrates 0-7 nitric oxide synthase 2 Homo sapiens 177-198 25554360-1 2015 Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways. Nitrates 105-112 nitric oxide synthase 2 Homo sapiens 177-198 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 56-63 ferredoxin--nitrite reductase, chloroplastic Zea mays 168-185 24944085-0 2015 Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis. Nitrates 33-40 SLAC1 homologue 3 Arabidopsis thaliana 14-19 24944085-5 2015 Interestingly, such toxicity was more severe in slah3 mutants and, particularly in wild-type plants, was alleviated by supplementing the media with micromolar levels of nitrate. Nitrates 169-176 SLAC1 homologue 3 Arabidopsis thaliana 48-53 24944085-6 2015 These data thus provide evidence that SLAH3, a nitrate efflux channel, plays a role in nitrate-dependent alleviation of ammonium toxicity in plants. Nitrates 47-54 SLAC1 homologue 3 Arabidopsis thaliana 38-43 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 56-63 glutamine synthetase root isozyme 2 Zea mays 187-209 25588735-7 2015 Furthermore, nitrate levels in the ppc1/ppc2 mutant were significantly lower than those in wild-type plants due to the suppression of ammonium assimilation. Nitrates 13-20 phosphoenolpyruvate carboxylase 1 Arabidopsis thaliana 35-39 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 nitrate transport 2 Zea mays 132-136 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 ferredoxin--nitrite reductase, chloroplastic Zea mays 168-185 25588735-7 2015 Furthermore, nitrate levels in the ppc1/ppc2 mutant were significantly lower than those in wild-type plants due to the suppression of ammonium assimilation. Nitrates 13-20 phosphoenolpyruvate carboxylase 2 Arabidopsis thaliana 40-44 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 glutamine synthetase root isozyme 2 Zea mays 187-209 25588735-8 2015 Interestingly, starch and sucrose accumulation could be prevented and nitrate levels could be maintained by supplying the ppc1/ppc2 mutant with exogenous malate and glutamate, suggesting that low nitrogen status resulted in the alteration of carbon metabolism and prompted the accumulation of starch and sucrose in the ppc1/ppc2 mutant. Nitrates 70-77 phosphoenolpyruvate carboxylase 1 Arabidopsis thaliana 122-126 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 nitrate transport 2 Zea mays 132-136 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 ferredoxin--nitrite reductase, chloroplastic Zea mays 168-185 25524070-7 2015 On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase. Nitrates 113-120 glutamine synthetase root isozyme 2 Zea mays 187-209 25598207-7 2015 Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2 AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process. Nitrates 57-64 anoctamin 2 Homo sapiens 10-14 25598207-7 2015 Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2 AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process. Nitrates 57-64 anoctamin 2 Homo sapiens 154-158 25598207-7 2015 Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2 AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process. Nitrates 57-64 anoctamin 2 Homo sapiens 154-158 27682076-8 2015 Sulphate- and nitrate-reducing microbes were particularly responsive to the addition of C-1 compounds and sulphate. Nitrates 14-21 heterogeneous nuclear ribonucleoprotein C Homo sapiens 88-91 25723764-0 2015 AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip. Nitrates 24-31 myb-like transcription factor family protein Arabidopsis thaliana 8-12 25596127-0 2015 AtTGA4, a bZIP transcription factor, confers drought resistance by enhancing nitrate transport and assimilation in Arabidopsis thaliana. Nitrates 77-84 TGACG motif-binding factor 4 Arabidopsis thaliana 0-6 25596127-5 2015 Following drought stress there were higher nitrogen and proline contents in transgenic AtTGA4 plants than in wild type controls, and activity of the key enzyme nitrite reductase (NIR) involved in nitrate assimilation processes was also higher. Nitrates 196-203 nitrite reductase 1 Arabidopsis thaliana 160-177 25596127-6 2015 Expressions of the high-affinity nitrate transporter genes NRT2.1 and NRT2.2 and nitrate reductase genes NIA1 and NIA2 in transgenic plants were all higher than in wild type indicating that higher levels of nitrate transport and assimilation activity contributed to enhanced drought resistance of AtTGA4 transgenic plants. Nitrates 33-40 nitrate transporter 2:1 Arabidopsis thaliana 59-65 25596127-6 2015 Expressions of the high-affinity nitrate transporter genes NRT2.1 and NRT2.2 and nitrate reductase genes NIA1 and NIA2 in transgenic plants were all higher than in wild type indicating that higher levels of nitrate transport and assimilation activity contributed to enhanced drought resistance of AtTGA4 transgenic plants. Nitrates 33-40 nitrate transporter 2.2 Arabidopsis thaliana 70-76 25638054-6 2015 The central part of the study area showed elevated nitrate concentration ranging from below detection limit (BDL) to 263.5 mg/l as NO3 (-) and demonstrated high attenuation within the immediate vicinity thereby restricting diffusion of the nitrate to the adjacent parts. Nitrates 51-58 NBL1, DAN family BMP antagonist Homo sapiens 131-134 25638054-8 2015 Seventy-seven percent of samples with high nitrate concentration (>45 mg/l as NO3 (-)) showed strong association with high Cl/Br mass ratio (350-900), indicating mixing of sewage and septic tank effluents with groundwater as a primary source for the nitrate in the studied area. Nitrates 43-50 NBL1, DAN family BMP antagonist Homo sapiens 81-84 25638054-8 2015 Seventy-seven percent of samples with high nitrate concentration (>45 mg/l as NO3 (-)) showed strong association with high Cl/Br mass ratio (350-900), indicating mixing of sewage and septic tank effluents with groundwater as a primary source for the nitrate in the studied area. Nitrates 253-260 NBL1, DAN family BMP antagonist Homo sapiens 81-84 25638054-9 2015 Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 49-52 25638054-9 2015 Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 92-95 25638054-9 2015 Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 92-95 25416287-0 2015 NODULE INCEPTION antagonistically regulates gene expression with nitrate in Lotus japonicus. Nitrates 65-72 nin Lotus japonicus 0-16 25292296-8 2015 The presence of high SO4 (2-)/nitrate (NO3 (-)) concentrations indicated that the burning of coals gives significant contributions to PM10 and PM2.5. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 39-42 25056869-4 2015 The bEnd3 cells were exposed to 100 muM Hcy treatment in the presence or absence of 30 muM NaHS (donor of H2S) for 24 h. Hcy-activate NMDA receptor and induced mitochondrial toxicity by increased levels of Ca(2+), NADPH-oxidase-4 (NOX-4) expression, mitochondrial dehydrogenase activity and decreased the level of nitrate, superoxide dismutase (SOD-2) expression, mitochondria membrane potentials, ATP production. Nitrates 314-321 BEN domain containing 3 Mus musculus 4-9 25592012-0 2015 Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study. Nitrates 122-129 nitric oxide synthase 3 Homo sapiens 28-61 25592012-4 2015 The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation. Nitrates 189-196 nitric oxide synthase 3 Homo sapiens 74-107 25592012-4 2015 The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation. Nitrates 189-196 nitric oxide synthase 3 Homo sapiens 109-113 25592012-12 2015 A significant difference in the concentration of serum nitrate was detected among individuals with MTHFR C > T677 polymorphisms. Nitrates 55-62 methylenetetrahydrofolate reductase Homo sapiens 99-104 25494936-6 2015 First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression. Nitrates 139-146 uncharacterized protein Chlamydomonas reinhardtii 21-25 25494936-6 2015 First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression. Nitrates 139-146 uncharacterized protein Chlamydomonas reinhardtii 30-34 25494936-6 2015 First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression. Nitrates 139-146 uncharacterized protein Chlamydomonas reinhardtii 97-101 25494936-7 2015 Furthermore, THB1 is highly expressed in the presence of NO and is able to convert NO into nitrate in vitro. Nitrates 91-98 uncharacterized protein Chlamydomonas reinhardtii 13-17 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 220-227 nin Lotus japonicus 16-32 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 220-227 nin Lotus japonicus 34-37 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 220-227 nin Lotus japonicus 164-167 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 300-307 nin Lotus japonicus 16-32 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 300-307 nin Lotus japonicus 34-37 25416287-2 2015 Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate. Nitrates 300-307 nin Lotus japonicus 164-167 25416287-4 2015 However, nodulation is inhibited in the presence of nitrate, and involvement of NIN in nitrate responses has remained largely unknown. Nitrates 87-94 nin Lotus japonicus 80-83 25416287-6 2015 Chromatin immunoprecitiation (ChIP)-PCR analyses showed that NIN targeted NREs in L. japonicus nitrate-inducible gene promoters, including LjNIR1, LjNRT2.1 and LjNRT2.2. Nitrates 95-102 nin Lotus japonicus 61-64 25416287-9 2015 NIN ectopic expression interfered with nitrate-dependent activation of these genes. Nitrates 39-46 nin Lotus japonicus 0-3 25416287-10 2015 Nitrate treatment followed by NIN activation down-regulated expression of symbiotic NIN target genes. Nitrates 0-7 nin Lotus japonicus 84-87 25416287-11 2015 Our results showed that NIN and nitrate antagonistically regulate expression of genes that are activated by nitrate and NIN, respectively. Nitrates 32-39 nin Lotus japonicus 120-123 25416287-11 2015 Our results showed that NIN and nitrate antagonistically regulate expression of genes that are activated by nitrate and NIN, respectively. Nitrates 108-115 nin Lotus japonicus 24-27 25678741-10 2015 The P(O)OH groups maintain their ability to bind metal ions within the HAP matrix: contacting the modified HAP with 10-4 N nitrate solutions of five transition metal ions gives an affinity sequence of Pb(II) > Cd(II) > Zn(II) > Ni(II) > Cu(II). Nitrates 123-130 submaxillary gland androgen regulated protein 3B Homo sapiens 201-207 25064505-1 2015 Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized. Nitrates 33-40 mitochondrially encoded cytochrome c oxidase II Homo sapiens 62-68 26451288-3 2015 Recently, we employed a combined histological, metabolomics, and transcriptional and protein analysis approach to establish that nitrate promoted the "browning" of white adipose tissue via the xanthine oxidoreductase catalyzed reductive nitrate-nitrite-nitric oxide pathway. Nitrates 129-136 xanthine dehydrogenase Homo sapiens 193-216 26451288-3 2015 Recently, we employed a combined histological, metabolomics, and transcriptional and protein analysis approach to establish that nitrate promoted the "browning" of white adipose tissue via the xanthine oxidoreductase catalyzed reductive nitrate-nitrite-nitric oxide pathway. Nitrates 237-244 xanthine dehydrogenase Homo sapiens 193-216 25922551-5 2015 The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2"-deoxyguanosine, and nitrite/nitrate. Nitrates 272-279 pentraxin 3 Homo sapiens 39-43 25431333-1 2015 The oxidation of elemental palladium at 100 C in a mixture of fuming nitric acid and a pyridine-SO3 complex leads to the anhydrous nitrate Pd(NO3)2 (monoclinic, P2(1)/n, Z=2, a=469.12(3) pm, b=593.89(3) pm, c=805.72(4) pm, beta=105.989(3) , V=215.79(2) A(3)). Nitrates 132-139 H3 histone pseudogene 16 Homo sapiens 162-167 25459828-0 2015 Enhanced removal of nitrate using starch/PCL blends as solid carbon source in a constructed wetland. Nitrates 20-27 PHD finger protein 1 Homo sapiens 41-44 24840342-3 2015 Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, blocks the appearance of the morphology alterations and the sustained decrease in nitrates and nitrites levels induced by PMA. Nitrates 226-234 proline rich transmembrane protein 2 Homo sapiens 30-33 25312438-0 2015 Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension. Nitrates 0-7 angiotensinogen Homo sapiens 75-89 25312440-3 2015 We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability. Nitrates 46-53 angiotensinogen Homo sapiens 145-159 25312440-3 2015 We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability. Nitrates 46-53 angiotensinogen Homo sapiens 161-167 25312440-12 2015 Moreover, supplementation with dietary nitrate (10(-2) mol/L) reduced renal NADPH oxidase activity and attenuated ANG II-mediated arteriolar contractions and hypertension (99+-2-146+-2 mm Hg) compared with placebo (100+-3-168+-3 mm Hg). Nitrates 39-46 angiotensinogen Homo sapiens 114-120 25512598-3 2015 We found that permeant ions such as nitrate can increase the open probability (Po) of wild-type (WT) CFTR by increasing the opening rate and decreasing the closing rate. Nitrates 36-43 CF transmembrane conductance regulator Homo sapiens 101-105 25512598-5 2015 Surprisingly, the effects of nitrate on CFTR gating are remarkably similar to those of VX-770 (N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide), a potent CFTR potentiator used in clinics. Nitrates 29-36 CF transmembrane conductance regulator Homo sapiens 40-44 25830329-1 2015 NRT1.1 is a dual-affinity nitrate (NO3(-)) transporter involved in both high- and low-affinity NO3(-) uptake in Arabidopsis plants. Nitrates 26-33 nitrate transporter 1.1 Arabidopsis thaliana 0-6 25878398-4 2015 Interestingly, the NOS3 -786TT genotype was associated with increased nitrite/nitrate levels only in IEI patients. Nitrates 78-85 nitric oxide synthase 3 Homo sapiens 19-23 25878398-8 2015 Here, we first demonstrate that NOS3 -786T>C variant affects nitrite/nitrate levels in IEI patients and that screening for NOS2A -2.5 kb (CCTTT) n polymorphism may be useful for differential diagnosis of various IEI. Nitrates 72-79 nitric oxide synthase 3 Homo sapiens 32-36 25480007-6 2015 The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P. Nitrates 42-49 hexokinase 1 Arabidopsis thaliana 83-87 25480007-6 2015 The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P. Nitrates 42-49 hexokinase 1 Arabidopsis thaliana 129-135 25480007-6 2015 The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P. Nitrates 42-49 hexokinase 1 Arabidopsis thaliana 150-161 25480007-6 2015 The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P. Nitrates 42-49 hexokinase 1 Arabidopsis thaliana 131-135 26039467-6 2015 Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation. Nitrates 42-49 CM0216.560.nc Lotus japonicus 150-154 26039467-0 2015 Shoot HAR1 mediates nitrate inhibition of nodulation in Lotus japonicus. Nitrates 20-27 CM0216.560.nc Lotus japonicus 6-10 26252500-0 2015 THB1 regulates nitrate reductase activity and THB1 and THB2 transcription differentially respond to NO and the nitrate/ammonium balance in Chlamydomonas. Nitrates 15-22 uncharacterized protein Chlamydomonas reinhardtii 0-4 26039467-2 2015 In a model legume Lotus japonicus, a CLV1-like receptor kinase, HAR1, mediates nitrate inhibition and autoregulation of nodulation. Nitrates 79-86 CM0216.560.nc Lotus japonicus 64-68 26039467-5 2015 We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate. Nitrates 69-76 CM0216.560.nc Lotus japonicus 43-47 26039467-5 2015 We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate. Nitrates 69-76 CM0216.560.nc Lotus japonicus 110-114 26039467-5 2015 We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate. Nitrates 169-176 CM0216.560.nc Lotus japonicus 43-47 26039467-5 2015 We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate. Nitrates 169-176 CM0216.560.nc Lotus japonicus 110-114 26039467-6 2015 Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation. Nitrates 42-49 CM0216.560.nc Lotus japonicus 101-105 26039467-6 2015 Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation. Nitrates 215-222 CM0216.560.nc Lotus japonicus 101-105 26039467-6 2015 Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation. Nitrates 215-222 CM0216.560.nc Lotus japonicus 150-154 26252500-12 2015 Thus, when cells are assimilating nitrate and NO appears (i.e. as a consequence of nitrite accumulation), THB1 has a double role: 1) to scavenge NO avoiding its toxic effects and 2) to control the nitrate reduction activity. Nitrates 197-204 uncharacterized protein Chlamydomonas reinhardtii 106-110 26252500-5 2015 THB1 and THB2 are regulated by the nitrogen source and respond differentially to NO and the nitrate/ammonium balance. Nitrates 92-99 uncharacterized protein Chlamydomonas reinhardtii 0-4 26252500-5 2015 THB1 and THB2 are regulated by the nitrogen source and respond differentially to NO and the nitrate/ammonium balance. Nitrates 92-99 uncharacterized protein Chlamydomonas reinhardtii 9-13 26252500-7 2015 THB1 has NOD activity and thus a role in nitrate assimilation. Nitrates 41-48 uncharacterized protein Chlamydomonas reinhardtii 0-4 26252500-8 2015 In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation. Nitrates 32-39 uncharacterized protein Chlamydomonas reinhardtii 9-13 26252500-8 2015 In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation. Nitrates 108-115 uncharacterized protein Chlamydomonas reinhardtii 9-13 26252500-8 2015 In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation. Nitrates 108-115 uncharacterized protein Chlamydomonas reinhardtii 68-72 26252500-12 2015 Thus, when cells are assimilating nitrate and NO appears (i.e. as a consequence of nitrite accumulation), THB1 has a double role: 1) to scavenge NO avoiding its toxic effects and 2) to control the nitrate reduction activity. Nitrates 34-41 uncharacterized protein Chlamydomonas reinhardtii 106-110 25281097-6 2015 A limit of detection of 24 muM nitrate and a linear concentration range of 200-1400 muM is reported for the microtrench sensor in phosphate buffer and dilute horse serum. Nitrates 31-38 latexin Homo sapiens 27-30 25059539-8 2015 Insulin and gliclazide have significantly attenuated, naloxone induced behavioral changes like jumping and rearing frequency, forepaw licking, wet dog shake, sneezing, straightening, circling, OMWS, and various biochemical impairments such as serum glucose, brain MDA, GSH, nitrite/nitrate, and Ca(+2) in morphine-dependent animals (invivo). Nitrates 282-289 insulin Canis lupus familiaris 0-7 26247758-5 2015 A maximum specific nitrate removal rate equal to 0.35 g N-NO3- g VSS(-1) d(-1) was reached in R1. Nitrates 19-26 NBL1, DAN family BMP antagonist Homo sapiens 58-61 25281097-6 2015 A limit of detection of 24 muM nitrate and a linear concentration range of 200-1400 muM is reported for the microtrench sensor in phosphate buffer and dilute horse serum. Nitrates 31-38 latexin Homo sapiens 84-87 25462758-1 2015 Nitrate (NO3-) is commonly dosed in sewer systems to reduce sulfide (H2S) and methane (CH4) produced in anaerobic rising main pipes. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 25551441-5 2014 In addition to Norg mineralization, Nx also originated from photochemical nitrate (NO3-) reduction. Nitrates 74-81 NBL1, DAN family BMP antagonist Homo sapiens 83-86 25492123-11 2014 CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR. Nitrates 163-170 DJ64_RS10945 Streptomyces griseorubens 220-237 25514572-0 2014 Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: the National Health and Nutrition Examination Survey 2005-2006. Nitrates 87-94 parathyroid hormone Homo sapiens 35-54 25461888-7 2014 NO3-(15)N and NO3-(18)O isotope data indicated the nitrate losses were due to denitrification. Nitrates 51-58 NBL1, DAN family BMP antagonist Homo sapiens 0-3 25492123-11 2014 CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR. Nitrates 163-170 DJ64_RS09700 Streptomyces griseorubens 239-259 25492123-11 2014 CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR. Nitrates 163-170 DJ64_RS08780 Streptomyces griseorubens 261-307 25243423-7 2014 Furthermore, HSC70 decreased LPS-induced elevation of circulating tumor necrosis factor alpha and nitrite/nitrate, and tissue expression of inducible nitric oxide synthase, cyclooxygenase 2, and matrix metalloproteinase 9 in the heart and liver. Nitrates 106-113 heat shock protein family A (Hsp70) member 8 Rattus norvegicus 13-18 24670328-1 2014 Our objective was to investigate whether the presence of Glu298Asp polymorphism in the endothelial NO synthase (eNOS) gene differentially affects the postprandial blood pressure response to dietary nitrate-rich beetroot bread. Nitrates 198-205 nitric oxide synthase 3 Homo sapiens 112-116 24670328-7 2014 The beneficial diastolic blood pressure reduction was observed only in the T carriers of the Glu298Asp polymorphism in the eNOS gene after consumption of nitrate-rich beetroot bread. Nitrates 154-161 nitric oxide synthase 3 Homo sapiens 123-127 25452706-3 2014 The mechanism of action of PDE-5 inhibitors results in a potential cumulative drop in blood pressure (BP); thus, these agents are contraindicated in patients receiving nitrates. Nitrates 168-176 phosphodiesterase 5A Homo sapiens 27-32 25505423-6 2014 Nitrite/nitrate decreased from 23 (18-27) muM at baseline to 19 (14-24) muM and 18 (14-21) muM in hypoxia and recovery, respectively (p < 0.05). Nitrates 8-15 latexin Homo sapiens 42-45 25310505-1 2014 Accurately quantifying nitrate (NO3-) loading from the Mississippi River is important for predicting summer hypoxia in the Gulf of Mexico and targeting nutrient reduction within the basin. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 32-35 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrates 47-54 nitric oxide synthase 3 Homo sapiens 0-4 25239655-2 2014 NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival. Nitrates 47-54 nitric oxide synthase 2 Homo sapiens 9-13 25188017-6 2014 All the CuFe(1-x)Cr(x)S2 (0 <= x <= 0.4) samples show considerably higher photocatalytic activities than P25 toward the reduction of nitrate ions in aqueous solution. Nitrates 139-146 tubulin polymerization promoting protein Homo sapiens 111-114 25280017-1 2014 Nitrate (NO3-) is one of the most harmful contaminants in the groundwater, and it causes various health problems. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 25349351-12 2014 However, ADG was not affected by nitrate dose (P = 0.54), resulting in a linear improvement in G:F (P = 0.03) as dietary nitrate level increased. Nitrates 121-128 ADG Bos taurus 9-12 24149973-10 2014 TPO antibodies were significant predictors of free T4 among non-pregnant women only when the models included urinary perchlorate, nitrate, or thiocyanate. Nitrates 130-137 thyroid peroxidase Homo sapiens 0-3 25163536-10 2014 The absence of eNOS leads to enhanced plasma nitrite levels following nitrate administration in vivo, which negatively impacts on platelet function. Nitrates 70-77 nitric oxide synthase 3 Homo sapiens 15-19 25174989-0 2014 The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance. Nitrates 107-115 aldehyde dehydrogenase 2 family member Homo sapiens 61-85 25163536-7 2014 Inorganic nitrite drove cGMP-mediated inhibition of human platelet aggregation in vitro and nitrate inhibited platelet function in eNOS(-/-) mice in vivo in a model of thromboembolic radiolabeled platelet aggregation associated with an enhanced plasma nitrite concentration as compared with wild-type mice. Nitrates 92-99 nitric oxide synthase 3 Homo sapiens 131-135 25174989-0 2014 The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance. Nitrates 107-114 aldehyde dehydrogenase 2 family member Homo sapiens 61-85 25174989-1 2014 Bioconversion of glyceryl trinitrate (GTN) into nitric oxide (NO) by aldehyde dehydrogenase-2 (ALDH-2) is a crucial mechanism which drives vasodilatory and antiplatelet effect of organic nitrates in vitro and in vivo. Nitrates 187-195 aldehyde dehydrogenase 2 family member Homo sapiens 69-93 25174989-1 2014 Bioconversion of glyceryl trinitrate (GTN) into nitric oxide (NO) by aldehyde dehydrogenase-2 (ALDH-2) is a crucial mechanism which drives vasodilatory and antiplatelet effect of organic nitrates in vitro and in vivo. Nitrates 187-195 aldehyde dehydrogenase 2 family member Homo sapiens 95-101 25174989-11 2014 In conclusion, oxidative stress subsequent to prolonged use of organic nitrates, which occurs via nitration of ALDH-2, represents a key event in GTN tolerance, an effect counteracted both in vitro and in vivo by novel peroxynitrite decomposition catalyst. Nitrates 71-79 aldehyde dehydrogenase 2 family member Homo sapiens 111-117 25229208-0 2014 Secondary organic aerosol formation and organic nitrate yield from NO3 oxidation of biogenic hydrocarbons. Nitrates 48-55 NBL1, DAN family BMP antagonist Homo sapiens 67-70 25412694-6 2014 Spatial statistics revealed that ZIP codes with more dairy farms and a higher dairy cow density had higher levels of nitrate contamination. Nitrates 117-124 fibroblast activation protein alpha Bos taurus 33-36 25288754-0 2014 Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Nitrates 0-7 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 78-83 25271384-1 2014 Nitrate (NO3(-)) is an abundant component of aerosols, boundary layer surface films, and surface water. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 25288754-4 2014 TCP20, which belongs to an ancient, plant-specific gene family that regulates shoot, flower, and embryo development, was implicated in nitrate signaling by its ability to bind DNA in more than 100 nitrate-regulated genes. Nitrates 135-142 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 0-5 25288754-5 2014 Analysis of insertion mutants of TCP20 showed that they had normal primary and lateral root growth on homogenous nitrate media but were impaired in preferential lateral root growth (root foraging) on heterogeneous media in split-root plates. Nitrates 113-120 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 33-38 25288754-6 2014 Inhibition of preferential lateral root growth was still evident in the mutants even when ammonium was uniformly present in the media, indicating that the TCP20 response was to nitrate. Nitrates 177-184 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 155-160 25288754-8 2014 Further analysis showed that tcp20 mutants lack systemic control of root growth regardless of the local nitrate concentrations. Nitrates 104-111 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 29-34 25288754-9 2014 These results indicate that TCP20 plays a key role in the systemic signaling pathway that directs nitrate foraging by Arabidopsis roots. Nitrates 98-105 TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20 Arabidopsis thaliana 28-33 24999115-5 2014 In addition, nitrate reduction by nZVI could be catalyzed by Cd(II): while 30% of nitrate was reduced by nZVI within 2 h in the absence of Cd(II), complete nitrate reduction was observed in the presence of 40 mg-Cd/L due to the formation of Cd islands (Cd(0) and CdO) on the nZVI particles. Nitrates 82-89 cell adhesion associated, oncogene regulated Homo sapiens 263-266 25310225-11 2014 Acetylcholine also increased the nitrate/nitrite concentration in TRPC3 WT mice, but not in KO mice. Nitrates 33-40 transient receptor potential cation channel, subfamily C, member 3 Mus musculus 66-71 24999115-5 2014 In addition, nitrate reduction by nZVI could be catalyzed by Cd(II): while 30% of nitrate was reduced by nZVI within 2 h in the absence of Cd(II), complete nitrate reduction was observed in the presence of 40 mg-Cd/L due to the formation of Cd islands (Cd(0) and CdO) on the nZVI particles. Nitrates 13-20 cell adhesion associated, oncogene regulated Homo sapiens 263-266 24700131-11 2014 Using ethanol as carbon source, nitrate (N-NO3(-)) removal efficiency of the bioreactor stood around 80 % for a maximum nitrogen loading rate of approximately 6.5 mg N-NO3 (-) L(-1) h(-1). Nitrates 32-39 NNO3 Homo sapiens 41-46 24700131-11 2014 Using ethanol as carbon source, nitrate (N-NO3(-)) removal efficiency of the bioreactor stood around 80 % for a maximum nitrogen loading rate of approximately 6.5 mg N-NO3 (-) L(-1) h(-1). Nitrates 32-39 NNO3 Homo sapiens 166-171 24913625-1 2014 NPF (formerly referred to as low-affinity NRT1) and "high-affinity" NRT2 nitrate transporter genes are involved in nitrate uptake by the root, and transport and distribution of nitrate within the plant. Nitrates 73-80 high-affinity nitrate transporter 2.1 Triticum aestivum 68-72 24913625-1 2014 NPF (formerly referred to as low-affinity NRT1) and "high-affinity" NRT2 nitrate transporter genes are involved in nitrate uptake by the root, and transport and distribution of nitrate within the plant. Nitrates 115-122 high-affinity nitrate transporter 2.1 Triticum aestivum 68-72 24987011-6 2014 Arabidopsis NLP7 in particular is a major player in the primary nitrate response. Nitrates 64-71 NIN like protein 7 Arabidopsis thaliana 12-16 25249806-6 2014 CONCLUSION: Early epidemiological studies demonstrated significant associations between high groundwater nitrate levels and elevated methemoglobin levels in infants fed drinking water-diluted formulas. Nitrates 105-112 hemoglobin subunit gamma 2 Homo sapiens 133-146 25039575-0 2014 Systems approach identifies TGA1 and TGA4 transcription factors as important regulatory components of the nitrate response of Arabidopsis thaliana roots. Nitrates 106-113 bZIP transcription factor family protein Arabidopsis thaliana 28-32 25065551-0 2014 The Arabidopsis nitrate transporter NRT2.5 plays a role in nitrate acquisition and remobilization in nitrogen-starved plants. Nitrates 16-23 nitrate transporter 2:1 Arabidopsis thaliana 36-40 25065551-6 2014 Reduction of NRT2.5 expression resulted in a decrease in high-affinity nitrate uptake without impacting low-affinity uptake. Nitrates 71-78 nitrate transporter 2:1 Arabidopsis thaliana 13-17 25065551-7 2014 In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants. Nitrates 39-46 nitrate transporter 2:1 Arabidopsis thaliana 66-70 25065551-7 2014 In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants. Nitrates 39-46 nitrate transporter 2:1 Arabidopsis thaliana 77-81 25039575-0 2014 Systems approach identifies TGA1 and TGA4 transcription factors as important regulatory components of the nitrate response of Arabidopsis thaliana roots. Nitrates 106-113 TGACG motif-binding factor 4 Arabidopsis thaliana 37-41 25065551-7 2014 In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants. Nitrates 39-46 nitrate transporter 2:1 Arabidopsis thaliana 77-81 25065551-8 2014 Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization. Nitrates 199-206 nitrate transporter2.5 Arabidopsis thaliana 72-78 25039575-2 2014 Using an integrative bioinformatics approach we identified TGA1 and TGA4 as putative regulatory factors that mediate nitrate responses in Arabidopsis roots. Nitrates 117-124 bZIP transcription factor family protein Arabidopsis thaliana 59-63 25065551-8 2014 Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization. Nitrates 273-280 nitrate transporter2.5 Arabidopsis thaliana 72-78 25039575-2 2014 Using an integrative bioinformatics approach we identified TGA1 and TGA4 as putative regulatory factors that mediate nitrate responses in Arabidopsis roots. Nitrates 117-124 TGACG motif-binding factor 4 Arabidopsis thaliana 68-72 25065551-8 2014 Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization. Nitrates 273-280 nitrate transporter2.5 Arabidopsis thaliana 72-78 25039575-4 2014 Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs. Nitrates 127-134 bZIP transcription factor family protein Arabidopsis thaliana 85-89 25039575-4 2014 Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs. Nitrates 127-134 TGACG motif-binding factor 4 Arabidopsis thaliana 90-94 25039575-4 2014 Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs. Nitrates 215-222 bZIP transcription factor family protein Arabidopsis thaliana 85-89 25039575-4 2014 Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs. Nitrates 215-222 TGACG motif-binding factor 4 Arabidopsis thaliana 90-94 25039575-7 2014 The tga1 tga4 double mutant plants exhibit nitrate-dependent lateral and primary root phenotypes. Nitrates 43-50 bZIP transcription factor family protein Arabidopsis thaliana 4-13 25039575-9 2014 Additional root phenotypes of tga1 tga4 double mutants indicate that these transcription factors play an important role in root developmental responses to nitrate. Nitrates 155-162 bZIP transcription factor family protein Arabidopsis thaliana 30-39 25039575-10 2014 These results identify TGA1 and TGA4 as important regulatory factors of the nitrate response in Arabidopsis roots. Nitrates 76-83 bZIP transcription factor family protein Arabidopsis thaliana 23-27 25106820-2 2014 Here, we show that cadmium inhibits nitrate transporter 1.1 (NRT1.1)-mediated nitrate (NO3 (-)) uptake in Arabidopsis (Arabidopsis thaliana) and impairs NO3 (-) homeostasis in roots. Nitrates 36-43 nitrate transporter 1.1 Arabidopsis thaliana 61-67 25039575-10 2014 These results identify TGA1 and TGA4 as important regulatory factors of the nitrate response in Arabidopsis roots. Nitrates 76-83 TGACG motif-binding factor 4 Arabidopsis thaliana 32-36 25326291-1 2014 Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance. Nitrates 18-25 nitrate transporter 1.1 Arabidopsis thaliana 166-170 25326291-1 2014 Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance. Nitrates 18-25 nitrate transporter 1.1 Arabidopsis thaliana 177-181 25326291-1 2014 Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance. Nitrates 83-90 nitrate transporter 1.1 Arabidopsis thaliana 166-170 25326291-1 2014 Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance. Nitrates 83-90 nitrate transporter 1.1 Arabidopsis thaliana 177-181 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 69-86 25173937-0 2014 Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish. Nitrates 0-7 tyrosine hydroxylase Danio rerio 93-113 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 277-294 25173937-2 2014 Both nitrate and nitrite exposure decreased the expression of tyrosine hydroxylase (TH) in dopaminergic neurons at 48hpf. Nitrates 5-12 tyrosine hydroxylase Danio rerio 62-82 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 33-40 estrogen receptor 1 Danio rerio 69-86 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 33-40 estrogen receptor 1 Danio rerio 277-294 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 33-40 estrogen receptor 1 Danio rerio 296-298 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 69-86 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 296-298 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 277-294 25173937-4 2014 When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER). Nitrates 170-177 estrogen receptor 1 Danio rerio 296-298 25247426-4 2014 The nitrate removal activity of a biofilm attached to the aspen wood from the bioreactor after 784 days of operation was 0.42 g NO3-N/kg dry weight wood day. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 128-131 25124942-1 2014 A novel discrete open high-nuclearity nest-like silver thiolate cluster complex, [Ag33 S3 (StBu)16 (CF3 COO)9 (NO3 )(CH3 CN)2 ](NO3 ) (1), has been isolated with nitrate and S(2-) anions acting as structure-directing templates. Nitrates 162-169 NBL1, DAN family BMP antagonist Homo sapiens 111-114 25124942-1 2014 A novel discrete open high-nuclearity nest-like silver thiolate cluster complex, [Ag33 S3 (StBu)16 (CF3 COO)9 (NO3 )(CH3 CN)2 ](NO3 ) (1), has been isolated with nitrate and S(2-) anions acting as structure-directing templates. Nitrates 162-169 NBL1, DAN family BMP antagonist Homo sapiens 128-131 25148521-1 2014 Nitrate (NO3-) is a widespread contaminant of groundwater and surface water across the United States that has deleterious effects to human and ecological health. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 24666321-0 2014 Infrared photodissociation spectroscopy of microhydrated nitrate-nitric acid clusters NO3(-)(HNO3)(m)(H2O)(n). Nitrates 57-64 NBL1, DAN family BMP antagonist Homo sapiens 86-89 24666321-5 2014 Addition of at least one more nitric acid molecule or two more water molecules weakens the hydrogen bond network, breaking the symmetry of this arrangement and leading to localization of the proton near one of the nitrate cores, effectively forming HNO3 hydrogen-bonded to NO3(-). Nitrates 214-221 NBL1, DAN family BMP antagonist Homo sapiens 250-253 25039985-0 2014 The intrinsically disordered structural platform of the plant defence hub protein RPM1-interacting protein 4 provides insights into its mode of action in the host-pathogen interface and evolution of the nitrate-induced domain protein family. Nitrates 203-210 RPM1 interacting protein 4 Arabidopsis thaliana 82-108 25053401-8 2014 We also investigated an animal model of CKD (Col4a3(-/-) mice) that displays highly elevated serum FGF23 levels and found they had impaired endothelium-dependent vascular relaxation and reduced nitrate production compared with age-matched wild types. Nitrates 194-201 collagen, type IV, alpha 3 Mus musculus 45-51 24718849-6 2014 Before admission, a higher percentage of COPD patients had experienced infections (25.0 vs. 14.0 %, p < 0.001), and were more likely to receive diuretics (p = 0.006), ACE inhibitors (p = 0.042), nitrates (p = 0.003), and digoxin (p = 0.034). Nitrates 198-206 COPD Homo sapiens 41-45 25039985-3 2014 AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family. Nitrates 20-27 RPM1 interacting protein 4 Arabidopsis thaliana 0-6 25039985-3 2014 AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family. Nitrates 20-27 RPM1-interacting protein 4 (RIN4) family protein Arabidopsis thaliana 37-40 25039985-3 2014 AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family. Nitrates 20-27 RPM1-interacting protein 4 (RIN4) family protein Arabidopsis thaliana 73-76 23894175-6 2014 Nitrate concentrations averaged 13.6 +- 3.7 muM and 12.7 +- 4.9 muM, respectively. Nitrates 0-7 latexin Homo sapiens 44-47 24914193-7 2014 The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg. Nitrates 135-142 endothelin 1 Rattus norvegicus 4-8 24914193-7 2014 The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg. Nitrates 135-142 endothelin receptor type B Rattus norvegicus 62-66 23894175-6 2014 Nitrate concentrations averaged 13.6 +- 3.7 muM and 12.7 +- 4.9 muM, respectively. Nitrates 0-7 latexin Homo sapiens 64-67 24548141-0 2014 Chlamydomonas NZF1, a tandem-repeated zinc finger factor involved in nitrate signalling by controlling the regulatory gene NIT2. Nitrates 69-76 uncharacterized protein Chlamydomonas reinhardtii 123-127 25193828-6 2014 The areas showing predicted nitrate concentrations in the leachate above the EU groundwater quality standard of 50mg NO3(-)/L have been identified as priority areas for implementing nitrogen reduction measures. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 117-120 24548141-1 2014 The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth. Nitrates 64-71 uncharacterized protein Chlamydomonas reinhardtii 30-34 24548141-1 2014 The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth. Nitrates 64-71 uncharacterized protein Chlamydomonas reinhardtii 92-96 24548141-1 2014 The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth. Nitrates 137-144 uncharacterized protein Chlamydomonas reinhardtii 30-34 24548141-4 2014 However, intracellular nitrate is required to activate NIT2 for subsequent expression of NIA1 and other nitrate assimilation genes. Nitrates 23-30 uncharacterized protein Chlamydomonas reinhardtii 55-59 24548141-4 2014 However, intracellular nitrate is required to activate NIT2 for subsequent expression of NIA1 and other nitrate assimilation genes. Nitrates 104-111 uncharacterized protein Chlamydomonas reinhardtii 55-59 24858657-1 2014 BACKGROUND: In this substudy of the effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes, we report the development of a novel nitrate depleted beetroot juice for use clinical trials and determine if dietary nitrate supplementation improved cognitive function in patients with type 2 diabetes mellitus. Nitrates 184-191 insulin Homo sapiens 107-114 24859195-4 2014 The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2. Nitrates 4-11 endogenous retrovirus group W member 5 Homo sapiens 217-220 24859195-4 2014 The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2. Nitrates 4-11 endogenous retrovirus group W member 5 Homo sapiens 401-404 24858657-1 2014 BACKGROUND: In this substudy of the effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes, we report the development of a novel nitrate depleted beetroot juice for use clinical trials and determine if dietary nitrate supplementation improved cognitive function in patients with type 2 diabetes mellitus. Nitrates 184-191 insulin Homo sapiens 107-114 25522608-9 2014 The contents of nitrate nitrogen in the root and leaves reached the highest at the NH4(+) -N/NO3(-) -N ratio of 50:50. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 93-96 25140876-1 2014 The ANR1 MADS-box gene in Arabidopsis is a key gene involved in regulating lateral root development in response to the external nitrate supply. Nitrates 128-135 AGAMOUS-like 44 Arabidopsis thaliana 4-8 25158065-5 2014 Therefore, we hypothesized that nitrate tolerance induced by persistent GTN treatment results from NOS3 dysfunction and vascular toxicity. Nitrates 32-39 nitric oxide synthase 3, endothelial cell Mus musculus 99-103 24858219-1 2014 Water pollution in the form of nitrate nitrogen (NO3(-)-N) contamination is a major concern in most agricultural areas in the world. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 49-52 24858219-6 2014 Overall, the highest nitrate levels were observed in surface water in May and in groundwater in June, indicating that fertilizer application, precipitation, and irrigation strongly influence the NO3(-)-N concentrations. Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 195-198 25101106-1 2014 The dynamics of nitrate (NO(-) 3), a major nitrogen (N) source for natural plants, has been studied mostly through experimental N addition, enzymatic assay, isotope labeling, and genetic expression. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 25-32 25127459-4 2014 Still, denitrification alone can often account for only half of the substantial nitrate (NO3-) consumption. Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 89-92 25127459-8 2014 Intriguingly, we also observed that between 20 and 40% of 15NO3- added to the incubations entered an intracellular pool of NO3- and was subsequently respired when nitrate became limiting. Nitrates 163-170 NBL1, DAN family BMP antagonist Homo sapiens 60-63 25001619-4 2014 Under optimal conditions, the limits of detection and quantification for nitrite are 1.0 and 7.8 muM, respectively, while the corresponding values for nitrate are 19 and 48 muM, respectively. Nitrates 151-158 latexin Homo sapiens 173-176 24791832-1 2014 Although interest in biomarkers in the nitrate-nitrite-NO pathway has recently increased, associations between nitrite (NO2(-)) and nitrate (NO3(-)), and asthma, allergic sensitisation and rhinitis remain unclear. Nitrates 132-139 NBL1, DAN family BMP antagonist Homo sapiens 141-144 24829498-7 2014 NOS1 protein expression, however, significantly increased with HS only in SHR, and this corresponded to an increase in urinary nitrate/nitrite excretion. Nitrates 127-134 nitric oxide synthase 1 Rattus norvegicus 0-4 25071800-2 2014 A central reaction in the cycle involves the reduction of nitrate (NO(-) 3) to nitrite (NO(-) 2) catalyzed by nitrate reductase (NR). Nitrates 58-65 nitrate reductase 1 Arabidopsis thaliana 110-127 24854623-4 2014 The effect of nitrate concentration on the extraction of lanthanides with 1-MIM in ILs was analysed. Nitrates 14-21 MTSS I-BAR domain containing 1 Homo sapiens 76-79 25373851-12 2014 We found higher PTX3 concentrations in patients with Canadian Cardiovascular Society (CCS) functional class 3 (compared to CCS functional class 2) and in patients taking nitrates. Nitrates 170-178 pentraxin 3 Homo sapiens 16-20 25005229-2 2014 The Arabidopsis thaliana anion/proton exchanger AtCLCa is involved in vacuolar accumulation of nitrate. Nitrates 95-102 chloride channel A Arabidopsis thaliana 48-54 24875878-4 2014 In a second step, a simple linear model is proposed for nitrate-DOC relationship (alpha NO3+beta DOC=1) and a validation is proposed for more than 150 samples of different Brittany rivers and lakes. Nitrates 56-63 cyclin dependent kinase 2 associated protein 1 Homo sapiens 97-102 25373851-15 2014 CONCLUSIONS: PTX3 is a marker of clinically more advanced CAD (CCS2 vs CCS3; nitrates vs no nitrates). Nitrates 77-85 pentraxin 3 Homo sapiens 13-17 25373851-15 2014 CONCLUSIONS: PTX3 is a marker of clinically more advanced CAD (CCS2 vs CCS3; nitrates vs no nitrates). Nitrates 92-100 pentraxin 3 Homo sapiens 13-17 24742815-7 2014 Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells. Nitrates 164-171 sphingomyelin phosphodiesterase 2 Homo sapiens 22-27 24742815-7 2014 Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells. Nitrates 164-171 sphingomyelin phosphodiesterase 2 Homo sapiens 29-36 24430487-5 2014 As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids. Nitrates 32-39 NSF attachment protein alpha Homo sapiens 3-7 24430487-5 2014 As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids. Nitrates 184-191 NSF attachment protein alpha Homo sapiens 3-7 24799562-0 2014 Disruption of the mitochondrial alternative oxidase (AOX) and uncoupling protein (UCP) alters rates of foliar nitrate and carbon assimilation in Arabidopsis thaliana. Nitrates 110-117 alternative oxidase 2 Arabidopsis thaliana 32-51 24799562-0 2014 Disruption of the mitochondrial alternative oxidase (AOX) and uncoupling protein (UCP) alters rates of foliar nitrate and carbon assimilation in Arabidopsis thaliana. Nitrates 110-117 alternative oxidase 2 Arabidopsis thaliana 53-56 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrates 83-90 Integral membrane HPP family protein Arabidopsis thaliana 17-26 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrates 83-90 Integral membrane HPP family protein Arabidopsis thaliana 43-52 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrates 178-185 Integral membrane HPP family protein Arabidopsis thaliana 17-26 24904028-8 2014 Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids. Nitrates 178-185 Integral membrane HPP family protein Arabidopsis thaliana 43-52 25158487-2 2014 The results showed that there were different forms of N transport by subsurface flow under different rainfall events, where in dissolved nitrogen (DN) accounted for about 53.74% - 99.21%, and nitrate (NO3(-) -N) accounted for about 35.70% - 93.65% of DN, and especially under the moderate rainfall, NO3(-) -N could reach 84.09% - 93.65% of DN. Nitrates 192-199 NBL1, DAN family BMP antagonist Homo sapiens 201-204 24748593-2 2014 The present study was designed to evaluate the relationship between exercise training and NOS3 polymorphisms at -786T>C, 894G>T, and intron 4b/a on blood pressure (BP) using 24-h ambulatory BP monitoring (ABPM), nitrate/nitrite levels (NOx), and redox state. Nitrates 218-225 nitric oxide synthase 3 Homo sapiens 90-94 24662464-0 2014 Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition. Nitrates 0-7 cytochrome c, somatic Equus caballus 22-34 24938289-9 2014 Changing the polar character of a single amino acid side chain (Ser-228) to a nonpolar residue turned the nitrate-selective SLAH2 into a chloride/nitrate-permeable anion channel. Nitrates 146-153 SLAC1 homologue 2 Arabidopsis thaliana 124-129 24663342-6 2014 Treatment of mEL5 with nitrate or nitrite caused meristematic cell death accompanied by browning. Nitrates 23-30 epilepsy 5 Mus musculus 13-17 25191617-7 2014 Betalains, polyphenols and dietary nitrate found in the beetroot juice may each contribute to the observed differences in the postprandial insulin concentration. Nitrates 35-42 insulin Homo sapiens 139-146 24938289-0 2014 A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective. Nitrates 78-85 SLAC1 homologue 2 Arabidopsis thaliana 65-70 24938289-3 2014 The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions. Nitrates 143-150 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 59-78 24938289-3 2014 The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions. Nitrates 143-150 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 80-85 24938289-3 2014 The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions. Nitrates 143-150 SLAC1 homologue 3 Arabidopsis thaliana 103-120 24938289-3 2014 The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions. Nitrates 143-150 SLAC1 homologue 3 Arabidopsis thaliana 122-127 24938289-4 2014 By contrast, we identified SLAH2 as a nitrate-specific channel that is impermeable for chloride. Nitrates 38-45 SLAC1 homologue 2 Arabidopsis thaliana 27-32 24938289-5 2014 To understand the molecular basis for nitrate selection in the SLAH2 channel, SLAC1 and SLAH2 were modeled to the structure of HiTehA, a distantly related bacterial member. Nitrates 38-45 SLAC1 homologue 2 Arabidopsis thaliana 63-68 24938289-5 2014 To understand the molecular basis for nitrate selection in the SLAH2 channel, SLAC1 and SLAH2 were modeled to the structure of HiTehA, a distantly related bacterial member. Nitrates 38-45 SLAC1 homologue 2 Arabidopsis thaliana 88-93 24938289-6 2014 Structure-guided site-directed mutations converted SLAC1 into a SLAH2-like nitrate-specific anion channel and vice versa. Nitrates 75-82 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 51-56 24938289-6 2014 Structure-guided site-directed mutations converted SLAC1 into a SLAH2-like nitrate-specific anion channel and vice versa. Nitrates 75-82 SLAC1 homologue 2 Arabidopsis thaliana 64-69 24938289-9 2014 Changing the polar character of a single amino acid side chain (Ser-228) to a nonpolar residue turned the nitrate-selective SLAH2 into a chloride/nitrate-permeable anion channel. Nitrates 106-113 SLAC1 homologue 2 Arabidopsis thaliana 124-129 24512212-7 2014 Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NOx). Nitrates 188-195 nitric oxide synthase 2 Rattus norvegicus 14-18 24594525-2 2014 In vitro tests revealed that compounds 3 and 5, which bear a nitrate moiety in the molecule, showed a potent inhibition activity towards AChE and compound 3 showed a good Abeta42 aggregation inhibitory activity. Nitrates 61-68 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-141 24555687-1 2014 Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of aldehyde dehydrogenase 2 (ALDH2), and decreased GTN-induced cGMP accumulation and vasodilation. Nitrates 13-21 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 103-127 24555687-1 2014 Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of aldehyde dehydrogenase 2 (ALDH2), and decreased GTN-induced cGMP accumulation and vasodilation. Nitrates 13-21 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 129-134 24633562-7 2014 Tap water and bottled water were also analyzed by the column, and nitrate was detected as 20.1 and 13.8 mg L(-1), respectively. Nitrates 66-73 nuclear RNA export factor 1 Homo sapiens 0-3 24356583-1 2014 The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water). Nitrates 365-372 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 4-8 24617811-1 2014 This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)). Nitrates 150-157 NBL1, DAN family BMP antagonist Homo sapiens 159-162 24617811-3 2014 Nitrate-mediated photooxidation of As(III) revealed an initial lag phase during which NO3(-) is converted into NO2(-). Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 86-89 24463937-7 2014 Whereas, Ang-(1-9) increased endothelial nitric oxide synthase mRNA levels in aorta as well as plasma nitrate levels. Nitrates 102-109 angiogenin Rattus norvegicus 9-17 24553295-7 2014 However, hydrocarbon removal in FTF 5 under anaerobic conditions with nitrate and sulphate electron acceptors was limited suggesting that aerobic conditions were crucial for hydrocarbon removal. Nitrates 70-77 nuclear receptor subfamily 5 group A member 2 Homo sapiens 32-35 24623305-1 2014 To monitor nitrate and peptide transport activity in vivo, we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4, and 5 into fluorescence activity sensors (NiTrac1, PepTrac). Nitrates 90-97 cell adhesion molecule L1 like Homo sapiens 110-114 24601645-4 2014 Describing uranyl and nitrate ions with integer charges (+2 and -1, respectively) is shown to exaggerate the hydrophilicity and surface activity of the UO2(NO3)2(TBP)2 complex. Nitrates 22-29 TATA-box binding protein Homo sapiens 162-165 24512498-7 2014 The mixing and gradient formation units were incorporated into a device for analysis of nitrate in tap water with standard addition as a single run and multiple depth detection cells to provide an extended linear range. Nitrates 88-95 nuclear RNA export factor 1 Homo sapiens 99-102 24623305-1 2014 To monitor nitrate and peptide transport activity in vivo, we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4, and 5 into fluorescence activity sensors (NiTrac1, PepTrac). Nitrates 90-97 immunoglobulin superfamily member 9 Homo sapiens 115-119 24142995-5 2014 Elevated pre-transplant levels of serum nitrates (>26.5 muM) predicted steroid-refractory graft-versus-host disease (P=0.026) and non-relapse mortality (P=0.028), particularly in combination with high pre-transplant angiopoietin-2 levels (P=0.0007 and P=0.021, respectively). Nitrates 40-48 angiopoietin 2 Homo sapiens 219-233 24572362-2 2014 Previous studies have identified Arabidopsis NRT1.1 as a dual-affinity nitrate transporter that can take up nitrate over a wide range of concentrations. Nitrates 71-78 nitrate transporter 1.1 Arabidopsis thaliana 45-49 24572362-7 2014 Together with analyses of the substrate transport tunnel, our results establish a phosphorylation-controlled dimerization switch that allows NRT1.1 to uptake nitrate with two distinct affinity modes. Nitrates 158-165 nitrate transporter 1.1 Arabidopsis thaliana 141-145 24572366-0 2014 Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1. Nitrates 19-26 nitrate transporter 1.1 Arabidopsis thaliana 67-73 24572366-3 2014 In response to falling nitrate levels, NRT1.1 is phosphorylated on an intracellular threonine that switches the transporter from a low-affinity to high-affinity state. Nitrates 23-30 nitrate transporter 1.1 Arabidopsis thaliana 39-43 24572366-4 2014 Here we present both the apo and nitrate-bound crystal structures of Arabidopsis thaliana NRT1.1, which together with in vitro binding and transport data identify a key role for His 356 in nitrate binding. Nitrates 33-40 nitrate transporter 1.1 Arabidopsis thaliana 90-96 24572366-4 2014 Here we present both the apo and nitrate-bound crystal structures of Arabidopsis thaliana NRT1.1, which together with in vitro binding and transport data identify a key role for His 356 in nitrate binding. Nitrates 189-196 nitrate transporter 1.1 Arabidopsis thaliana 90-96 24337990-9 2014 Denuder-fitted PM1 sampler can serve as a useful sampling tool in estimating the true values for nitrate, ammonium, potassium, sodium and WSOC present in the ambient PM. Nitrates 97-104 transmembrane protein 11 Homo sapiens 15-18 24532452-1 2014 NRT2.7 is a seed-specific high-affinity nitrate transporter controlling nitrate content in Arabidopsis mature seeds. Nitrates 40-47 nitrate transporter 2:1 Arabidopsis thaliana 0-4 24280052-4 2014 The initial nitrate concentration was 142mgL(-1), and the concentrations decreased by 80%, 84%, and 79% in System A, B, and C, respectively. Nitrates 12-19 LLGL scribble cell polarity complex component 1 Homo sapiens 41-47 24531490-0 2014 Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state. Nitrates 0-7 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 30-61 24363367-5 2014 We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter. Nitrates 66-73 Ssu1p Saccharomyces cerevisiae S288C 39-43 24194418-5 2014 The co-existence of two inorganic nitrogen sources (ammonia and nitrate) had certain impact on simazine dissipation by the strain SD1. Nitrates 64-71 CUP2Q35 Homo sapiens 130-133 24363367-5 2014 We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter. Nitrates 66-73 SCF ubiquitin ligase complex subunit GRR1 Saccharomyces cerevisiae S288C 48-52 24363367-5 2014 We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter. Nitrates 169-176 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 151-155 24363367-8 2014 We also have shown that the well-known Saccharomyces cerevisiae sulfite efflux permease Ssu1 is also able to excrete nitrite and nitrate. Nitrates 129-136 Ssu1p Saccharomyces cerevisiae S288C 88-92 24097244-4 2014 In addition, research has shown that there is crosstalk between the CBL-CIPK pathway and the low-K+ response pathway, the ABA signaling pathway, the nitrate sensing and signaling pathway, and others. Nitrates 149-156 Cbl proto-oncogene Homo sapiens 68-71 23731510-3 2014 A study was carried out to quantify the effects of the ND in the EU-27 on the leaching and runoff of nitrate (NO3(-)) to groundwater and surface waters, and on the emissions of ammonia (NH3), nitrous oxide (N2O), nitrogen oxides (NO(x)) and dinitrogen (N2) to the atmosphere. Nitrates 101-108 NBL1, DAN family BMP antagonist Homo sapiens 110-113 24388610-7 2014 Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development. Nitrates 107-114 CAPRICE-like MYB3 Arabidopsis thaliana 12-16 24388610-7 2014 Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development. Nitrates 107-114 CAPRICE-like MYB3 Arabidopsis thaliana 92-96 24388610-7 2014 Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development. Nitrates 107-114 CAPRICE-like MYB3 Arabidopsis thaliana 97-101 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Nitrates 7-14 nitric oxide synthase 2 Rattus norvegicus 73-104 24441717-5 2014 Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p<0.05). Nitrates 7-14 nitric oxide synthase 2 Rattus norvegicus 106-110 24346018-2 2014 Subsets of circulating blood cells, including red blood cells (RBCs), carry a NOS3 and contribute to blood pressure regulation and RBC nitrite/nitrate formation. Nitrates 143-150 nitric oxide synthase 3, endothelial cell Mus musculus 78-82 25020005-1 2014 Heavy carbon steel corrosion developed during nitrate mitigation of a flow rig connected to a water injection pipeline flowing anaerobe saline aquifer water. Nitrates 46-53 dickkopf WNT signaling pathway inhibitor 3 Homo sapiens 75-78 25114912-10 2014 Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. Nitrates 8-15 macrophage migration inhibitory factor Homo sapiens 44-47 25114912-12 2014 Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. Nitrates 48-55 macrophage migration inhibitory factor Homo sapiens 102-105 24183883-8 2014 In multiple regression analysis homocysteine, sVCAM-1, and urinary nitrate/nitrite remained independent determinants of resistin levels (R(2) adjusted=0.347, p=0.000). Nitrates 67-74 resistin Homo sapiens 120-128 25020005-4 2014 Nitrate amendment caused an 18-fold smaller SRB population, but up to 44 times higher sulfate reduction rates. Nitrates 0-7 chaperonin containing TCP1 subunit 4 Homo sapiens 44-47 25410225-10 2014 The use of PDE-5 inhibitors in the presence of oral nitrates is strictly contraindicated in diabetic men, as in nondiabetic subjects. Nitrates 52-60 phosphodiesterase 5A Homo sapiens 11-16 24923291-2 2014 The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor gamma agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety. Nitrates 43-50 cardiotrophin-like cytokine factor 1 Rattus norvegicus 17-20 23775870-9 2014 When considering NOC precursors, risk was consistently higher among subjects with concurrent high intake of nitrate and high intake of the different meats (sources of amines and nitrosamines). Nitrates 108-115 nocturnin Homo sapiens 17-20 24642889-10 2014 CONCLUSION: The present study demonstrated that nicorandil induces COX-2 via GATA-4 induction in the heart through both KATP channel activation and its nitrate-like properties. Nitrates 152-159 cytochrome c oxidase II, mitochondrial Rattus norvegicus 67-72 24642889-10 2014 CONCLUSION: The present study demonstrated that nicorandil induces COX-2 via GATA-4 induction in the heart through both KATP channel activation and its nitrate-like properties. Nitrates 152-159 GATA binding protein 4 Rattus norvegicus 77-83 24923291-4 2014 RESULTS: In vitro, CLC-3000 displayed more potent vasodilation than pioglitazone alone or classical nitrates. Nitrates 100-108 cardiotrophin-like cytokine factor 1 Rattus norvegicus 19-22 24923291-9 2014 CONCLUSION: In summary, the results of these studies demonstrate that CLC-3000 contains a vasodilative and antithrombotic activity that is not evident with pioglitazone alone, and that 7 days of exposure in vivo showed no typical signs of nitrate tolerance, endothelial dysfunction or other safety concerns in Wistar rats. Nitrates 239-246 cardiotrophin-like cytokine factor 1 Rattus norvegicus 70-73 24259683-4 2014 Expression in Xenopus laevis oocytes and two-electrode voltage clamp measurements showed that VvNPF3.2 is a low-affinity transporter for both nitrate and nitrite and displays characteristics of NPF members from other plants. Nitrates 142-149 protein NRT1/ PTR FAMILY 3.1 Vitis vinifera 94-102 23731054-0 2014 Auxin-mediated nitrate signalling by NRT1.1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability. Nitrates 15-22 nitrate transporter 1.1 Arabidopsis thaliana 37-41 23731054-0 2014 Auxin-mediated nitrate signalling by NRT1.1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability. Nitrates 147-154 nitrate transporter 1.1 Arabidopsis thaliana 37-41 23731054-4 2014 Using a split-root system, we explored the hypothesis that preferential lateral root growth in the nitrate-rich side involves the NRT1.1-dependent repression of lateral root growth in the low nitrate side. Nitrates 99-106 nitrate transporter 1.1 Arabidopsis thaliana 130-134 23731054-5 2014 Data show that NRT1.1 acts locally to modulate both auxin levels and meristematic activity in response to the low nitrate concentration directly experienced by lateral roots leading to a repression of their growth. Nitrates 114-121 nitrate transporter 1.1 Arabidopsis thaliana 15-19 23731054-6 2014 A stimulatory role of NRT1.1 in the high nitrate side, which does not rely on changes in auxin levels, is also observed. Nitrates 41-48 nitrate transporter 1.1 Arabidopsis thaliana 22-28 23731054-7 2014 Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism. Nitrates 82-89 nitrate transporter 1.1 Arabidopsis thaliana 34-40 23731054-7 2014 Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism. Nitrates 153-160 nitrate transporter 1.1 Arabidopsis thaliana 34-40 23731054-7 2014 Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism. Nitrates 153-160 nitrate transporter 1.1 Arabidopsis thaliana 34-40 23731054-8 2014 In addition, transcriptional regulation of NRT1.1 affects both mechanisms allowing plants to modulate the effect of nitrate on root branching. Nitrates 116-123 nitrate transporter 1.1 Arabidopsis thaliana 43-47 24272701-6 2014 Nitrate-mediated NRT2.1 expression is not influenced by gin2-1, showing that Glc does not influence NRT2.1 expression through nitrate-mediated mechanisms. Nitrates 0-7 nitrate transporter 2:1 Arabidopsis thaliana 17-23 24272701-7 2014 We also show that Glc stimulates NRT2.1 protein levels and transport activity independently of its HEXOKINASE1-mediated stimulation of NRT2.1 expression, demonstrating another possible posttranscriptional mechanism influencing nitrate uptake. Nitrates 227-234 nitrate transporter 2:1 Arabidopsis thaliana 33-39 24259683-5 2014 We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity. Nitrates 98-105 Major facilitator superfamily protein Arabidopsis thaliana 41-49 24259683-5 2014 We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity. Nitrates 98-105 Major facilitator superfamily protein Arabidopsis thaliana 67-75 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 0-7 auxin signaling F-box 3 Arabidopsis thaliana 22-26 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 45-52 auxin signaling F-box 3 Arabidopsis thaliana 70-74 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 0-7 NAC domain containing protein 80 Arabidopsis thaliana 31-35 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 45-52 NAC domain containing protein 80 Arabidopsis thaliana 110-114 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 181-187 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 151-158 auxin signaling F-box 3 Arabidopsis thaliana 70-74 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 151-158 NAC domain containing protein 80 Arabidopsis thaliana 110-114 24642706-3 2014 We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1. Nitrates 151-158 nitrate transporter 1.1 Arabidopsis thaliana 181-187 24642706-4 2014 This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches. Nitrates 191-198 nitrate transporter 1.1 Arabidopsis thaliana 33-39 24642706-4 2014 This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches. Nitrates 191-198 auxin signaling F-box 3 Arabidopsis thaliana 43-47 24642706-4 2014 This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches. Nitrates 191-198 NAC domain containing protein 80 Arabidopsis thaliana 52-56 24642706-4 2014 This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches. Nitrates 191-198 nitrate reductase 1 Arabidopsis thaliana 134-138 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 84-88 24642706-4 2014 This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches. Nitrates 191-198 nitrate reductase 2 Arabidopsis thaliana 143-147 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 91-98 auxin signaling F-box 3 Arabidopsis thaliana 22-26 24642706-5 2014 Our work suggests two different signaling pathways may exist to control gene expression in response to nitrate downstream of NRT1.1. Nitrates 103-110 nitrate transporter 1.1 Arabidopsis thaliana 125-131 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 91-98 NAC domain containing protein 80 Arabidopsis thaliana 31-35 24642706-0 2014 Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function. Nitrates 91-98 nitrate transporter 1.1 Arabidopsis thaliana 84-88 25187978-12 2014 In the group with ED, the serum level of endothelin 1 was higher compared with the group without ED (0.57 +-0.18 vs. 0.49 +-0.21 pg/ml; P = 0.032) and that of nitrates and nitrites was lower compared with the group without ED (15.2 [11.1-29.9] vs. 22.8 [16.9-33.0] mumol/l; P = 0.0005). Nitrates 159-167 endothelin 1 Homo sapiens 41-53 25187978-14 2014 In the group with ED, PTH inversely correlated with nitrates and nitrites (R = -0.48; P = 0.003). Nitrates 52-60 parathyroid hormone Homo sapiens 22-25 25187978-15 2014 CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium. Nitrates 194-202 parathyroid hormone Homo sapiens 46-49 25187978-15 2014 CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium. Nitrates 194-202 parathyroid hormone Homo sapiens 134-137 23993458-3 2014 It has been demonstrated that ultrasound can produce NOx (nitrate and nitrite), with a production rate of 2.2 muM min(-1). Nitrates 58-65 latexin Homo sapiens 110-113 24212048-5 2013 Most delta(15)NNO3 values were within ranges expected for nitrate formed by ammonia nitrification in soil. Nitrates 58-65 NNO3 Homo sapiens 14-18 23703110-5 2013 Using fish oil (0.0368 g EPA and 0.0184 g DHA, per day), melatonin (10 mg/kg/day), and vitamin E (50 mg/Kg/day) we have now shown that COX-2 activity, LPO and nitrite/nitrate levels were significantly increased in MPTP treated mice (p < 0.001) while fish oil, melatonin and vitamin E treatment were capable of decreasing significantly the outcome of all above noted parameters (p < 0.05). Nitrates 167-174 cytochrome c oxidase II, mitochondrial Mus musculus 135-140 24061044-3 2013 A detailed study of the nitrate derivative, based on the DFT analysis of the polarized spectra of single crystals, has been undertaken to propose the normal mode assignment of the Raman peaks in the low spin state of the compound. Nitrates 24-31 spindlin 1 Homo sapiens 203-207 24094891-5 2013 SYN-PC positively co-related with nitrate and phosphate and SYN-PEI with phosphate. Nitrates 34-41 synemin Homo sapiens 0-3 23452999-9 2013 Nitrate loading obtained after nitrification, denitrification, and NO3 removal from unsaturated and shallow aquifer zones is combined with groundwater recharge. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 67-70 26328121-8 2013 The use of PDE-5 inhibitors is absolutely contraindicated in patients taking nitrate preparations. Nitrates 77-84 phosphodiesterase 5A Homo sapiens 11-16 24096001-4 2013 It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater. Nitrates 64-71 NBL1, DAN family BMP antagonist Homo sapiens 135-138 24096001-4 2013 It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 135-138 24096001-4 2013 It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 135-138 23089892-9 2013 CART analysis showed that 30-day mortality among patients undergoing emergency CABG with unstable hemodynamic conditions was 32.60 % and it was 20.0 % in patients undergoing non-emergency operation with nitrates infusion at arrival in the operating room and left ventricular ejection fraction <30 %. Nitrates 203-211 CART prepropeptide Homo sapiens 0-4 23645597-0 2013 Arabidopsis NRT1.1 is a bidirectional transporter involved in root-to-shoot nitrate translocation. Nitrates 76-83 nitrate transporter 1.1 Arabidopsis thaliana 12-18 25518555-5 2013 We established that a NO scavenger, hemoglobin (4 muM), fully or partially removed the toxic effect of SNP, nitrate, and nitrite on growth. Nitrates 108-115 latexin Homo sapiens 50-53 23793091-7 2013 Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P<0.05) in the outer layer. Nitrates 21-28 S100 calcium binding protein B Homo sapiens 51-54 23793091-7 2013 Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P<0.05) in the outer layer. Nitrates 21-28 S100 calcium binding protein B Homo sapiens 70-73 23793091-7 2013 Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P<0.05) in the outer layer. Nitrates 59-66 S100 calcium binding protein B Homo sapiens 70-73 23850530-6 2013 Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at <1% O2. Nitrates 40-47 interleukin 1 beta Homo sapiens 13-21 23811105-6 2013 The activity of SOD and CAT decreased with the amount of nitrate and nitrite, while GSHPx and TBARS resulted unaffected. Nitrates 57-64 catalase Homo sapiens 24-27 24089435-0 2013 A reevaluation of the role of Arabidopsis NRT1.1 in high-affinity nitrate transport. Nitrates 66-73 nitrate transporter 1.1 Arabidopsis thaliana 42-48 24028846-9 2013 35SPro:SWEET16 plants exhibited increased growth efficiency when cultivated on soil and showed improved nitrogen use efficiency when nitrate was sufficiently available, while under conditions of limiting nitrogen, wild-type biomasses were higher than those of 35SPro:SWEET16 plants. Nitrates 133-140 Nodulin MtN3 family protein Arabidopsis thaliana 7-14 24058148-1 2013 Cytokinin activity in plants is closely related to nitrogen availability, and an Arabidopsis gene for adenosine phosphate-isopentenyltransferase (IPT), IPT3, is regulated by inorganic nitrogen sources in a nitrate-specific manner. Nitrates 206-213 isopentenyltransferase 3 Arabidopsis thaliana 152-156 24119003-5 2013 Our sequencing strategy identified new nitrate-regulated genes including 40 genes not represented in the ATH1 Affymetrix GeneChip, a novel nitrate-responsive antisense transcript and a new nitrate responsive miRNA/TARGET module consisting of a novel microRNA, miR5640 and its target, AtPPC3. Nitrates 39-46 phosphoenolpyruvate carboxylase 3 Arabidopsis thaliana 284-290 24119003-5 2013 Our sequencing strategy identified new nitrate-regulated genes including 40 genes not represented in the ATH1 Affymetrix GeneChip, a novel nitrate-responsive antisense transcript and a new nitrate responsive miRNA/TARGET module consisting of a novel microRNA, miR5640 and its target, AtPPC3. Nitrates 39-46 homeobox protein ATH1 Arabidopsis thaliana 105-109 23480350-0 2013 Regulation of nitrate reduction in Arabidopsis WT and hxk1 mutant under C and N metabolites. Nitrates 14-21 hexokinase 1 Arabidopsis thaliana 54-58 23917809-8 2013 Side effects and interactions of PDE 5 inhibitors with other drugs have been minimal, with the exception of their coadministration with nitrates, which could lead to severe vasodilation and hypotension and therefore, their coadministration is prohibited. Nitrates 136-144 phosphodiesterase 5A Homo sapiens 33-38 23480350-1 2013 As in plants sugar sensing and signal transduction involve pathways dependent or independent on hexokinase 1 (HXK1) as a glucose sensor, research was conducted to determine which pathway is responsible for regulation of the nitrate reduction. Nitrates 224-231 hexokinase 1 Arabidopsis thaliana 110-114 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 106-113 nitrate transporter 1.1 Arabidopsis thaliana 26-30 24006285-0 2013 Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth. Nitrates 11-18 nitrate transporter 1.1 Arabidopsis thaliana 33-37 24006285-0 2013 Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth. Nitrates 11-18 nitrate transporter 1.1 Arabidopsis thaliana 45-49 24006285-0 2013 Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth. Nitrates 99-106 nitrate transporter 1.1 Arabidopsis thaliana 33-37 24006285-0 2013 Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth. Nitrates 99-106 nitrate transporter 1.1 Arabidopsis thaliana 45-49 24006285-1 2013 This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth. Nitrates 53-60 nitrate transporter 1.1 Arabidopsis thaliana 74-78 24006285-1 2013 This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth. Nitrates 53-60 nitrate transporter 1.1 Arabidopsis thaliana 86-90 24006285-1 2013 This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth. Nitrates 158-165 nitrate transporter 1.1 Arabidopsis thaliana 74-78 24006285-1 2013 This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth. Nitrates 158-165 nitrate transporter 1.1 Arabidopsis thaliana 86-90 24006285-5 2013 In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues. Nitrates 227-234 nitrate transporter 1.1 Arabidopsis thaliana 3-7 24006285-5 2013 In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues. Nitrates 227-234 nitrate transporter 1.1 Arabidopsis thaliana 164-168 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 106-113 nitrate transporter 1.1 Arabidopsis thaliana 38-42 24006285-5 2013 In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues. Nitrates 227-234 nitrate transporter 1.1 Arabidopsis thaliana 176-180 24006285-6 2013 Distinct from the wild type, nrt1.11 nrt1.12 double mutants show no increase of plant growth at high nitrate supply. Nitrates 101-108 nitrate transporter 1.1 Arabidopsis thaliana 29-33 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 147-154 nitrate transporter 1.1 Arabidopsis thaliana 26-30 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 147-154 nitrate transporter 1.1 Arabidopsis thaliana 38-42 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 147-154 nitrate transporter 1.1 Arabidopsis thaliana 26-30 24006285-7 2013 These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate. Nitrates 147-154 nitrate transporter 1.1 Arabidopsis thaliana 38-42 24270631-0 2013 The evolutionary events necessary for the emergence of symbiotic nitrogen fixation in legumes may involve a loss of nitrate responsiveness of the NIN transcription factor. Nitrates 116-123 nin Lotus japonicus 146-149 24270626-7 2013 This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis. Nitrates 92-99 nitrate reductase 1 Arabidopsis thaliana 146-150 24270631-2 2013 NIN-like proteins (NLPs), which are presumably present in all land plants, were recently identified as key transcription factors in nitrate signaling and responses in Arabidopsis thaliana, a non-leguminous plant. Nitrates 132-139 nin Lotus japonicus 0-3 24270626-7 2013 This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis. Nitrates 92-99 nitrite reductase 1 Arabidopsis thaliana 175-179 24270626-7 2013 This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis. Nitrates 92-99 Plant regulator RWP-RK family protein Arabidopsis thaliana 188-206 24270631-3 2013 Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs). Nitrates 77-84 nin Lotus japonicus 23-26 24270626-7 2013 This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis. Nitrates 92-99 Plant regulator RWP-RK family protein Arabidopsis thaliana 208-212 24270631-3 2013 Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs). Nitrates 77-84 NLP1 Lotus japonicus 31-35 24270631-3 2013 Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs). Nitrates 77-84 NLP1 Lotus japonicus 53-59 24270631-5 2013 Thus, in the course of the evolution of NIN into a transcription factor that functions in nodulation in legumes, some mutations might arise that converted it to a nitrate-insensitive transcription factor. Nitrates 163-170 nin Lotus japonicus 40-43 24270631-6 2013 Because nodule formation is induced under nitrogen-deficient conditions, we speculate that the loss of the nitrate-responsiveness of NIN may be one of the evolutionary events necessary for the emergence of symbiotic nitrogen fixation in legumes. Nitrates 107-114 nin Lotus japonicus 133-136 23834222-5 2013 The first example of lead(II) borate nitrate, namely, [Pb3(B3O7)](NO3) (2), crystallizes in space group Pnma, and its structures features a 3D lead(II) borate cationic network structure in which (B3O7)(5-) anions are bridged by lead(II) cations, the nitrate anions are isolated, and located at the small voids of the cationic network. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 66-69 23820008-1 2013 Nitrate (NO3-) pollution in aquatic system is a worldwide problem. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 23734982-8 2013 Transcriptome analysis of homozygous viable nar1-4 seedlings showed transcriptional repression of a subset of genes involved in "iron ion transport" and "response to nitrate". Nitrates 166-173 ferredoxin hydrogenase Arabidopsis thaliana 44-48 23771693-0 2013 Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice. Nitrates 105-112 heme oxygenase 1 Mus musculus 126-142 23771693-1 2013 Previously we have shown that, unlike wild-type mice (WT), heme oxygenase-1 knockout (HO-1-/-) mice developed nitrate tolerance and were not protected from inflammation caused by ischemia-reperfusion (I/R) when preconditioned with a H2S donor. Nitrates 110-117 heme oxygenase 1 Mus musculus 59-75 23514778-0 2013 Chemolithotrophic nitrate-dependent Fe(II)-oxidizing nature of actinobacterial subdivision lineage TM3. Nitrates 18-25 tropomyosin 3 Homo sapiens 99-102 23943655-12 2013 In the unstable group, the total concentration of nitrite and nitrate at the last visit was 9.84 (6.65-11.24) muM. Nitrates 62-69 latexin Homo sapiens 110-113 23514778-4 2013 The incubations of sediment under chemolithotrophic nitrate-dependent Fe(II)-oxidizing conditions have shown the enrichment of TM3 group of uncultured Actinobacteria. Nitrates 52-59 tropomyosin 3 Homo sapiens 127-130 23514778-11 2013 To the best of our knowledge this is the first study to show the autotrophic nitrate-dependent Fe(II)-oxidizing nature of TM3 group of uncultured Actinobacteria. Nitrates 77-84 tropomyosin 3 Homo sapiens 122-125 23621281-5 2013 When N-deprived plants were fed via the roots with 15NO3 -, pgl3-1 exhibited normal induction of OPPP and nitrate assimilation genes in roots, and amino acids in roots and shoots were labeled with (15) N at least as rapidly as in the wild type. Nitrates 106-113 NagB/RpiA/CoA transferase-like superfamily protein Arabidopsis thaliana 60-64 23847199-0 2013 Systems approaches map regulatory networks downstream of the auxin receptor AFB3 in the nitrate response of Arabidopsis thaliana roots. Nitrates 88-95 auxin signaling F-box 3 Arabidopsis thaliana 76-80 23739688-1 2013 The paralogous and functionally redundant GATA transcription factors GNC (for GATA, NITRATE-INDUCIBLE, CARBON-METABOLISM INVOLVED) and GNL/CGA1 (for GNC-LIKE/CYTOKININ-RESPONSIVE GATA FACTOR1) from Arabidopsis (Arabidopsis thaliana) promote greening and repress flowering downstream from the phytohormone gibberellin. Nitrates 84-91 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 42-46 23847199-3 2013 We previously reported a role for AFB3 in coordinating primary and lateral root growth to nitrate availability. Nitrates 90-97 auxin signaling F-box 3 Arabidopsis thaliana 34-38 23847199-4 2013 In this work, we used an integrated genomics, bioinformatics, and molecular genetics approach to dissect regulatory networks acting downstream of AFB3 that are activated by nitrate in roots. Nitrates 173-180 auxin signaling F-box 3 Arabidopsis thaliana 146-150 23847199-5 2013 We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate. Nitrates 86-93 NAC domain containing protein 80 Arabidopsis thaliana 18-22 23847199-5 2013 We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate. Nitrates 86-93 NAC domain containing protein 80 Arabidopsis thaliana 123-127 23847199-5 2013 We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate. Nitrates 215-222 NAC domain containing protein 80 Arabidopsis thaliana 123-127 23847199-7 2013 Our systems approach has unraveled key components of the AFB3 regulatory network leading to changes in lateral root growth in response to nitrate. Nitrates 138-145 auxin signaling F-box 3 Arabidopsis thaliana 57-61 23683835-0 2013 Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Nitrates 21-29 aldo-keto reductase family 1 member B Homo sapiens 69-85 23983629-5 2013 Comparisons between measured and simulated data indicated that the NO3-N concentrations in the soil and nitrate leaching to drains are controlled by the fertilizer practice, the initial conditions and the rainfall depth and distribution. Nitrates 104-111 NBL1, DAN family BMP antagonist Homo sapiens 67-70 23820397-5 2013 In turn, this inflammatory response enhanced the luminal growth of E. coli by nitrate respiration in a Nos2-dependent fashion. Nitrates 78-85 nitric oxide synthase 2, inducible Mus musculus 103-107 23820397-9 2013 Here we show that streptomycin increases the inflammatory tone of the intestinal mucosa, thereby making the bowel more susceptible to dextran sulfate sodium treatment and boosting the Nos2-dependent growth of commensal Escherichia coli by nitrate respiration. Nitrates 239-246 nitric oxide synthase 2, inducible Mus musculus 184-188 23305042-0 2013 The nitrate transporter NRT2.1 functions in the ethylene response to nitrate deficiency in Arabidopsis. Nitrates 4-11 nitrate transporter 2:1 Arabidopsis thaliana 24-30 23666325-5 2013 However, in the nitrate- and sulfate-plus-lactate-amended microcosms, soluble As levels decreased to 0.01 and 0.41 +- 0.13 muM, respectively, by the end of the experiment. Nitrates 16-23 latexin Homo sapiens 123-126 23395779-0 2013 Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Nitrates 18-25 insulin Homo sapiens 71-78 23395779-4 2013 We sought to determine if supplementing dietary nitrate with beetroot juice, a rich source of nitrate, will lower BP and improve endothelial function and insulin sensitivity in individuals with type 2 diabetes (T2DM). Nitrates 48-55 insulin Homo sapiens 154-161 23305042-3 2013 However, molecular interaction between NRT2.1 transcript levels and the ethylene signalling pathway under nitrate deficiency is still elusive. Nitrates 106-113 nitrate transporter 2:1 Arabidopsis thaliana 39-45 23305042-2 2013 Previous studies have reported impact of high nitrate (HN) availability on ethylene biosynthesis and regulation of ethylene on nitrate transporter 2.1 (NRT2.1) expression. Nitrates 46-53 nitrate transporter 2:1 Arabidopsis thaliana 127-150 23305042-5 2013 LN treatment also caused up-regulation of NRT2.1 expression, which was responsible for an enhanced high-affinity nitrate uptake. Nitrates 113-120 nitrate transporter 2:1 Arabidopsis thaliana 42-48 23305042-2 2013 Previous studies have reported impact of high nitrate (HN) availability on ethylene biosynthesis and regulation of ethylene on nitrate transporter 2.1 (NRT2.1) expression. Nitrates 46-53 nitrate transporter 2:1 Arabidopsis thaliana 152-158 23662623-1 2013 Under Fe(3+)-reducing conditions, soil Fe(2+) oxidation has been shown to be coupled with nitrate (NO3(-)) reduction. Nitrates 90-97 NBL1, DAN family BMP antagonist Homo sapiens 99-102 23305042-8 2013 Together, these findings uncover a negative feedback loop between NRT2.1 expression and ethylene biosynthesis and signalling under nitrate deficiency, which may contribute to finely tuning of plant nitrate acquisition during exploring dynamic soil conditions. Nitrates 131-138 nitrate transporter 2:1 Arabidopsis thaliana 66-72 23305042-8 2013 Together, these findings uncover a negative feedback loop between NRT2.1 expression and ethylene biosynthesis and signalling under nitrate deficiency, which may contribute to finely tuning of plant nitrate acquisition during exploring dynamic soil conditions. Nitrates 198-205 nitrate transporter 2:1 Arabidopsis thaliana 66-72 23725033-3 2013 Nitrate is reduced at the Mo active site of NR, yielding the oxidized form of the enzyme, which is reactivated by the electro-reduced form of the mediator. Nitrates 0-7 nitrate reductase 1 Arabidopsis thaliana 44-46 23356444-8 2013 Plasma nitrite/nitrate levels were lower in patients with CSX than control subjects (15.9 +- 1.6 mumol/L vs. 25.4 +- 2.8 mumol/L, respectively; P < 0.001), and they have a significantly positive correlation with plasma adropin levels (r = 0.463, P < 0.001). Nitrates 15-22 NK2 homeobox 5 Homo sapiens 58-61 23470627-7 2013 Chronic inhibition of polyamine synthesis using an ornithine decarboxylase inhibitor significantly reduced polyamine levels, restored nitrite/nitrate levels to normal, and abrogated the AHR to methacholine in the acute model of allergic airways inflammation. Nitrates 142-149 ornithine decarboxylase, structural 1 Mus musculus 51-74 23356444-9 2013 In the multiple linear regression analysis, nitrite/nitrate levels, BMI, and adropin were found to be independent risk factors for CSX. Nitrates 52-59 NK2 homeobox 5 Homo sapiens 131-134 23590427-5 2013 Our results are consistent with a seed-specific response to seasonal temperature patterns (temporal sensing) involving the gene DELAY OF GERMINATION 1 (DOG1) that indicates the correct season, and concurrent temporally driven co-opted mechanisms that sense spatial signals, i.e. nitrate, via CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) phosphorylation of the NITRATE TRANSPORTER 1 (NRT1.1), and light, via PHYTOCHROME A (PHYA). Nitrates 279-286 delay of germination 1 Arabidopsis thaliana 152-156 24191599-5 2013 In river without highly circulating irrigation system or water gate effect, the downstream nitrate nitrogen (NO3-N) concentration increase occurred in area dominated by open field cultivation, whereas the NO3-N concentration was constant or decreased in area dominated by greenhouse land use. Nitrates 91-98 NBL1, DAN family BMP antagonist Homo sapiens 109-112 24621868-3 2013 Some of the benefits seen with hydralazine, including afterload reduction and attenuation of nitrate tolerance, have also been observed with angiotensin-converting enzyme inhibitors. Nitrates 93-100 angiotensin I converting enzyme Homo sapiens 141-170 24621868-4 2013 Demonstrating similar clinical benefits with nitrates plus angiotensin-converting enzyme inhibitor therapy alone, in the absence of hydralazine, may represent an opportunity to improve heart failure care by increasing the use of nitrates. Nitrates 229-237 angiotensin I converting enzyme Homo sapiens 59-88 23713126-2 2013 Leakages from the use of fertilizer Nr contribute to nitrate (NO3(-)) in drainage waters from agricultural land and emissions of trace Nr compounds to the atmosphere. Nitrates 53-60 NBL1, DAN family BMP antagonist Homo sapiens 62-65 23759982-1 2013 Extending our previous observations, we have shown on HaCat cells that melatonin, at ~10-9 M concentration, transiently raises not only the expression of the neuronal nitric oxide synthase (nNOS) mRNA, but also the nNOS protein synthesis and the nitric oxide oxidation products, nitrite and nitrate. Nitrates 291-298 nitric oxide synthase 1 Homo sapiens 190-194 23536322-11 2013 NaK-Ni7-Ale2 proved to be efficient for the electrocatalytic reduction of nitrate, nitrite and nitrous oxide. Nitrates 74-81 TANK binding kinase 1 Homo sapiens 0-3 23376235-7 2013 In the 27 patients on dialysis, baseline plasma nitrite and nitrate by HPLC were 0.21+-0.03 and 67.25+-14.68 muM, respectively. Nitrates 60-67 latexin Homo sapiens 109-112 23589565-9 2013 Our observations demonstrate the improved efficacy of inorganic nitrate and nitrite in hypertension as a consequence of increased erythrocytic XOR nitrite reductase activity and support the concept of dietary nitrate supplementation as an effective, but simple and inexpensive, antihypertensive strategy. Nitrates 64-71 xanthine dehydrogenase Homo sapiens 143-146 23515834-8 2013 According to Canonical Correspondence Analysis, pH, temperature, nitrite, and nitrate concentration strongly affected the diversity and distribution of anammox bacteria in South China Sea sediments. Nitrates 78-85 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 184-187 23394787-0 2013 Response to nitrate/ammonium nutrition of tomato (Solanum lycopersicum L.) plants overexpressing a prokaryotic NH4(+)-dependent asparagine synthetase. Nitrates 12-19 asparagine synthetase Solanum lycopersicum 128-149 23378445-11 2013 CONCLUSIONS: Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants. Nitrates 78-85 coagulation factor II, thrombin Homo sapiens 21-29 23463757-10 2013 ATbG-NOS3 haplotype homozygosity was associated with up to 64% higher nitrite/nitrate levels (P=0.003). Nitrates 78-85 nitric oxide synthase 3 Homo sapiens 5-9 23467180-4 2013 High riverine concentrations of nitrate (NO3; up to 220 muM) and phosphate (PO4; up to 3.7 muM) mainly originated from agricultural fertilizer input. Nitrates 32-39 latexin Homo sapiens 56-59 23386129-3 2013 Blockade of Mas with its antagonist A-779 in Bdkrb2(-/-) shortens thrombosis times (58 +- 4 minutes to 38 +- 4 minutes) and bleeding times (170 +- 13 seconds to 88 +- 8 seconds) and lowers plasma nitrate (22 +- 4 muM to 15 +- 5 muM), and 6-keto-PGF1alpha (259 +- 103 pg/mL to 132 +- 58 pg/mL). Nitrates 196-203 bradykinin receptor, beta 2 Mus musculus 45-51 23194305-10 2013 The results support the view that impaired ALDH2-catalysed metabolism of GTN contributes significantly to the development of vascular nitrate tolerance and reveal a hitherto unrecognized protective effect of ascorbate in the vasculature. Nitrates 134-141 aldehyde dehydrogenase 2, mitochondrial Mus musculus 43-48 23441627-8 2013 The high NOS-2 expression coincided with an exacerbated NO production in the infection focus and in plasma, as judging by nitrate + nitrite levels. Nitrates 122-129 nitric oxide synthase 2, inducible Mus musculus 9-14 23398541-8 2013 Using a nitrate reductase mutant, it was confirmed that the NRT2.5/NRT2.6-dependent plant signalling pathway is independent of nitrate-dependent regulation of root development. Nitrates 8-15 nitrate transporter 2:1 Arabidopsis thaliana 60-64 23398541-8 2013 Using a nitrate reductase mutant, it was confirmed that the NRT2.5/NRT2.6-dependent plant signalling pathway is independent of nitrate-dependent regulation of root development. Nitrates 8-15 nitrate transporter 2:1 Arabidopsis thaliana 67-71 23307651-1 2013 Plant nitrate (NO3(-)) acquisition depends on the combined activities of root high- and low-affinity NO3(-) transporters and the proton gradient generated by the plasma membrane H(+)-ATPase. Nitrates 6-13 plasma membrane H+-ATPase Arabidopsis thaliana 162-189 23461818-1 2013 Aqueous nitrate, NO3(-)(aq), was studied by 2D-IR, UV-IR, and UV-UV time-resolved spectroscopies in combination with molecular dynamics (MD) simulations with the purpose of determining the hydration dynamics around the anion. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 23387982-1 2013 In the atmosphere, mineral dust particles are often associated with adsorbed nitrate from heterogeneous reactions with nitrogen oxides (N2O5, HNO3, NO3, and NO2). Nitrates 77-84 NBL1, DAN family BMP antagonist Homo sapiens 143-146 23276425-4 2013 Titanium dioxide (Evonik P90), acting as photocatalyst, reduced nitrate effectively in both synthetic brines and sulfate-removed IX brine when formic acid (FA) was used as the hole scavenger (i.e., electron donor) and the initial FA to nitrate molar ratio (IFNR) was 5.6. Nitrates 64-71 cellular inhibitor of PP2A Homo sapiens 25-28 23250328-7 2013 Our system shows good correlation with controls up to 50 muM of nitrate, which adequately covers the healthy human range (4 to 45.3 muM). Nitrates 64-71 latexin Homo sapiens 57-60 23276425-4 2013 Titanium dioxide (Evonik P90), acting as photocatalyst, reduced nitrate effectively in both synthetic brines and sulfate-removed IX brine when formic acid (FA) was used as the hole scavenger (i.e., electron donor) and the initial FA to nitrate molar ratio (IFNR) was 5.6. Nitrates 236-243 cellular inhibitor of PP2A Homo sapiens 25-28 23276425-6 2013 In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles. Nitrates 28-35 cellular inhibitor of PP2A Homo sapiens 156-159 23276425-6 2013 In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles. Nitrates 28-35 cellular inhibitor of PP2A Homo sapiens 187-190 23276425-6 2013 In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles. Nitrates 120-127 cellular inhibitor of PP2A Homo sapiens 156-159 23250328-7 2013 Our system shows good correlation with controls up to 50 muM of nitrate, which adequately covers the healthy human range (4 to 45.3 muM). Nitrates 64-71 latexin Homo sapiens 132-135 23262000-5 2013 With adjustment of hydraulic retention time (HRT), the highest of nitrate removal efficiency (74.2+-1.4%) and organics utilization efficiency (0.63 mg NO3--N mg(-1)TOC) were achieved at an optimum HRT of 18 h, with both low effluent NO3--N (0.88+-0.03 mg l(-1)) and TOC (2.86+-0.67 mg l(-1)). Nitrates 66-73 NBL1, DAN family BMP antagonist Homo sapiens 233-236 23288160-8 2013 Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P<0.001) and higher nitrite/nitrate (P<0.001), whereas platelets from obese women had higher isoprostanes (P<0.001) and lower nitrite/nitrate (P=0.013). Nitrates 149-156 cytochrome b-245 beta chain Homo sapiens 78-82 23288160-8 2013 Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P<0.001) and higher nitrite/nitrate (P<0.001), whereas platelets from obese women had higher isoprostanes (P<0.001) and lower nitrite/nitrate (P=0.013). Nitrates 261-268 cytochrome b-245 beta chain Homo sapiens 78-82 23279126-10 2013 A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively. Nitrates 34-41 nitric oxide synthase, brain Cavia porcellus 197-201 22994391-1 2013 BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. Nitrates 145-153 aldehyde dehydrogenase 2 family member Homo sapiens 66-90 22994391-1 2013 BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation. Nitrates 145-153 aldehyde dehydrogenase 2 family member Homo sapiens 92-97 22994391-2 2013 Our objective was to assess the role of ALDH2 in organic nitrate action using a cell culture model. Nitrates 57-64 aldehyde dehydrogenase 2 family member Homo sapiens 40-45 23149826-8 2013 Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine. Nitrates 301-308 peroxisome proliferator-activated receptor gamma Rattus norvegicus 40-88 23149826-8 2013 Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine. Nitrates 301-308 peroxisome proliferator-activated receptor gamma Rattus norvegicus 90-99 23279126-10 2013 A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively. Nitrates 34-41 nitric oxide synthase, inducible Cavia porcellus 206-210 23200251-4 2013 hCA VIII was poorly inhibited by halides, cyanate, nitrate and sulfate (K(I)s of 38.4-65.4 mM), whereas CA XI had a behavior intermediate between that of hCA VIII and X, both regarding the catalytic activity and sensitivity to anion inhibitors. Nitrates 51-58 carbonic anhydrase 8 Homo sapiens 0-8 23215531-2 2013 The detection of vapors from the low volatility explosive compound RDX was achieved through selective atmospheric pressure chemical ionization using nitrate reactant ions (NO(3)(-)) and NO(3)(-) HNO(3) adducts generated in an electrical discharge source. Nitrates 149-156 radixin Homo sapiens 67-70 23215531-6 2013 Recorded signals were observed for RDX concentrations below 25 ppq using selected ion monitoring (SIM) of the RDX-nitrate adduct at m/z 284. Nitrates 114-121 radixin Homo sapiens 35-38 23215531-6 2013 Recorded signals were observed for RDX concentrations below 25 ppq using selected ion monitoring (SIM) of the RDX-nitrate adduct at m/z 284. Nitrates 114-121 radixin Homo sapiens 110-113 24396568-4 2013 TNF-alpha increased the levels of superoxide, Nox (nitrate and nitrite), malondialdehyde, and nitrotyrosine production, accompanied by increased protein expression of p-PKC-beta2, gP91phox, and endothelial cell apoptosis, whereas all these changes were further enhanced by nitroglycerine. Nitrates 51-58 tumor necrosis factor Homo sapiens 0-9 23008504-8 2013 However, the level of nitrate and nitrite, substrates of cytochrome P450 reductase, were higher in SHR than WKY plasma and aortae. Nitrates 22-29 cytochrome p450 oxidoreductase Rattus norvegicus 57-82 24396568-0 2013 Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-alpha: the role of PKC-beta2 and NADPH oxidase. Nitrates 23-30 tumor necrosis factor Homo sapiens 106-115 23004358-0 2013 The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Nitrates 13-20 TIR-NBS-LRR class disease resistance protein Arabidopsis thaliana 76-80 23004358-0 2013 The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Nitrates 13-20 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 94-98 23004358-0 2013 The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Nitrates 13-20 nudix hydrolase homolog 6 Arabidopsis thaliana 125-130 23111423-1 2013 A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. Nitrates 171-178 aldehyde dehydrogenase 2 family member Homo sapiens 36-60 23111423-1 2013 A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. Nitrates 171-178 aldehyde dehydrogenase 2 family member Homo sapiens 62-67 23004358-0 2013 The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7. Nitrates 13-20 MutT/nudix family protein Arabidopsis thaliana 133-138 23111423-1 2013 A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. Nitrates 171-178 superoxide dismutase 2 Homo sapiens 73-95 23111423-1 2013 A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance. Nitrates 171-178 superoxide dismutase 2 Homo sapiens 97-101 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrates 29-36 nudix hydrolase homolog 6 Arabidopsis thaliana 136-141 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrates 29-36 MutT/nudix family protein Arabidopsis thaliana 144-149 23004358-7 2013 We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity. Nitrates 29-36 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 196-200 23004358-8 2013 The low ammonium/nitrate ratio also enhances autoimmunity in snc1-1 and cpr1, two other autoimmune mutants in Arabidopsis. Nitrates 17-24 TIR-NBS-LRR class disease resistance protein Arabidopsis thaliana 61-67 23004358-8 2013 The low ammonium/nitrate ratio also enhances autoimmunity in snc1-1 and cpr1, two other autoimmune mutants in Arabidopsis. Nitrates 17-24 F-box and associated interaction domains-containing protein Arabidopsis thaliana 72-76 23004358-9 2013 Our study indicates that Arabidopsis senses the ammonium/nitrate ratio as an input signal to determine the amplitude of the EDS1-mediated defense response, probably through the modulation of NO production. Nitrates 57-64 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 124-128 24084651-3 2013 We hypothesized that the competition between nitrate and ABA as substrates for AtNPF4.6 might be involved in the interactions between nitrate and ABA signaling. Nitrates 45-52 nitrate transporter 1:2 Arabidopsis thaliana 79-87 24084651-3 2013 We hypothesized that the competition between nitrate and ABA as substrates for AtNPF4.6 might be involved in the interactions between nitrate and ABA signaling. Nitrates 134-141 nitrate transporter 1:2 Arabidopsis thaliana 79-87 24084651-5 2013 In addition, the npf4.6 mutant was less sensitive to ABA than the wild type during germination irrespective of nitrate concentrations in the media. Nitrates 111-118 nitrate transporter 1:2 Arabidopsis thaliana 17-23 24084651-6 2013 Furthermore, nitrate promoted germination of both wild type and npf4.6 in the presence of ABA. Nitrates 13-20 nitrate transporter 1:2 Arabidopsis thaliana 64-70 23469284-13 2013 Plasma nitrate/nitrite level was significantly reduced in AngII-infused mice (P<0.05). Nitrates 7-14 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 58-63 23199690-4 2013 The pdr1 mutant has proved potentially useful in understanding the responses to nitrate (Ni), P and cytokinin. Nitrates 80-87 pleiotropic drug resistance 1 Arabidopsis thaliana 4-8 23342065-6 2013 We further demonstrate that the exported POC:PON ratio varies regionally in relation to nitrate-based new production over geographical scales that range from the Arctic to the subtropics, being highest in the least productive oligotrophic Central Arctic Ocean and subtropical gyres. Nitrates 88-95 paraoxonase 1 Homo sapiens 45-48 23651488-2 2013 The aim of the present study was to analyze concentrations of nitrates and nitrites (NO2 + NO3) and L-arginine in patients with liver cirrhosis and HRS as a possible predictive marker for the development of HRS. Nitrates 62-70 NBL1, DAN family BMP antagonist Homo sapiens 91-94 23231781-8 2012 We also found consistent inverse associations of vWF with nitrate, chloride and sodium, and sP-selectin with manganese. Nitrates 58-65 von Willebrand factor Homo sapiens 49-52 22961095-6 2013 The iNOS inhibitors significantly inhibited the acrolein-increased nitrite/nitrate levels, but not IL-6 levels. Nitrates 75-82 nitric oxide synthase 2 Rattus norvegicus 4-8 23230319-0 2012 Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase". Nitrates 45-52 nitric oxide synthase 3 Homo sapiens 113-146 22811030-8 2012 Plasma ET-1 increased significantly (P < 0.05) just after exercise in nitrate (4.0 +- 0.8 pg mL) and placebo (2.4 +- 0.4 pg mL) conditions. Nitrates 73-80 endothelin 1 Homo sapiens 7-11 23230319-0 2012 Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase". Nitrates 45-52 thioredoxin reductase 1 Homo sapiens 160-175 23038808-5 2012 Here we determine the potential of marine prokaryotes from different sediments of the Atlantic Ocean and Mediterranean Sea to couple nitrate reduction to the oxidation of aromatic hydrocarbons. Nitrates 133-140 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 119-122 22796369-5 2012 KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux. Nitrates 151-159 fibrinogen beta chain Homo sapiens 56-66 23062112-2 2012 Cefazolin (CFZ) and cephapirin (CFP) underwent mainly direct photolysis (t(1/2) = 0.7, 3.9 h), while cephalexin (CFX) and cephradine (CFD) were mainly transformed by indirect photolysis, which during the process a bicarbonate-enhanced nitrate system contributed most to the loss rate of CFX, CFD, and cefotaxime (CTX) (t(1/2) = 4.5, 5.3, and 1.3 h, respectively). Nitrates 235-242 complement factor properdin Homo sapiens 32-35 22988236-6 2012 Assuming that the structures of the triple mutant and wild-type ALDH2 reflect binding of GTN to the catalytic site and the first reaction step, respectively, superposition of the two structures indicates that denitration of GTN is initiated by nucleophilic attack of Cys-302 at one of the terminal nitrate groups, resulting in formation of the observed thionitrate intermediate and release of 1,2-glyceryl dinitrate. Nitrates 298-305 aldehyde dehydrogenase 2 family member Homo sapiens 64-69 22982594-8 2012 PPARdelta activation increased the total nitrite and nitrate (NO2+NO3) content in cerebral microvessels (P<0.05, n=6). Nitrates 53-60 peroxisome proliferator activator receptor delta Mus musculus 0-9 22988236-7 2012 Our results shed light on the molecular mechanism of the GTN denitration reaction and provide useful information on the structural requirements for high affinity binding of organic nitrates to the catalytic site of ALDH2. Nitrates 181-189 aldehyde dehydrogenase 2 family member Homo sapiens 215-220 22683098-6 2012 RESULTS: We found that serum tNOx (total nitrite/nitrate; mumol/L) was lower in obese T2DM group (12.7+-3.5) when compared with their controls (21.1+-2.4), although the non-obese group presented higher concentration of tNOx (33.8+-7.2). Nitrates 49-56 ecto-NOX disulfide-thiol exchanger 2 Homo sapiens 29-33 22858636-2 2012 Of the NRT1(PTR) members known to transport nitrate, most are low-affinity transporters. Nitrates 44-51 nitrate transporter 1.1 Arabidopsis thaliana 7-11 22992322-9 2012 Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue. Nitrates 8-15 CD34 antigen Mus musculus 116-120 22992322-9 2012 Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue. Nitrates 8-15 kinase insert domain protein receptor Mus musculus 124-129 22992322-9 2012 Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue. Nitrates 8-15 platelet/endothelial cell adhesion molecule 1 Mus musculus 170-174 22992322-9 2012 Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue. Nitrates 8-15 protein tyrosine phosphatase, receptor type, C Mus musculus 178-182 22790675-0 2012 Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data. Nitrates 82-89 arginine deiminase Escherichia coli 47-51 22858636-4 2012 Heterologous expression experiments showed that MtNIP/LATD encodes a nitrate transporter: expression in Xenopus laevis oocytes conferred upon the oocytes the ability to take up nitrate from the medium with high affinity, and expression of MtNIP/LATD in an Arabidopsis chl1(nrt1.1) mutant rescued the chlorate susceptibility phenotype. Nitrates 69-76 nitrate transporter 1.1 Arabidopsis thaliana 273-277 22935372-3 2012 Coulometric analysis with the tubular membrane ISE showed that nitrate could be detected in the range 10-100 muM with a precision of 2.3% relative standard deviation (RSD), limit of detection of 1.1 muM and relative accuracy of 4.4% compared to a certified reference material (CRM) Lake sample. Nitrates 63-70 latexin Homo sapiens 109-112 22935372-3 2012 Coulometric analysis with the tubular membrane ISE showed that nitrate could be detected in the range 10-100 muM with a precision of 2.3% relative standard deviation (RSD), limit of detection of 1.1 muM and relative accuracy of 4.4% compared to a certified reference material (CRM) Lake sample. Nitrates 63-70 latexin Homo sapiens 199-202 22795587-1 2012 Zero-valent iron (Fe(0))-based permeable reactive barrier (PRB) technology has been proved to be effective for soil and groundwater nitrate remediation under acidic or near neutral conditions. Nitrates 132-139 RB transcriptional corepressor 1 Homo sapiens 59-62 22819707-3 2012 The daily administration of L-NAME (50mg/kg) for six weeks along with DADS analogs (20 mg/kg) significantly decreased the elevated systolic blood pressure (SBP) and the activity of angiotensin converting enzyme (ACE) and also inhibited the decline in nitrite/nitrate (NO(x)) concentrations and cyclic guanosine monophosphate (cGMP) levels. Nitrates 259-266 angiotensin I converting enzyme Rattus norvegicus 212-215 22795587-10 2012 The results implied that PRB based Fe(0) is a potential approach for in situ remediation of soil and groundwater nitrate contamination in the alkaline conditions. Nitrates 113-120 RB transcriptional corepressor 1 Homo sapiens 25-28 22810276-3 2012 Co(II) is hepta-coordinated by three N atoms from the bpy units, and four O atoms from two nitrate groups. Nitrates 91-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-6 22530997-3 2012 This study utilized experimental vernal pool microcosms to simulate persistent pH alteration and a pulse input of nitrate (NO3 -), which are common perturbations to temperate vernal pool ecosystems. Nitrates 114-121 NBL1, DAN family BMP antagonist Homo sapiens 123-126 22845863-8 2012 Finally, XPS analysis confirms that NO2 adsorbs on CaCO3 (1014) in the form of nitrate (NO3(-)) regardless of environmental conditions or the pretreatment of the calcite surface at different relative humidity. Nitrates 79-86 NBL1, DAN family BMP antagonist Homo sapiens 88-91 23031518-5 2012 In consistent with previous findings, catalase has been shown to play a major role in modulating the nitrosative stress by oxidizing nitrite to nitrate. Nitrates 144-151 catalase Bos taurus 38-46 24501070-1 2012 Nitrate (NO3 (-) ) export coupled with high inorganic nitrogen (N) concentrations in Alaskan streams suggests that N cycles of permafrost-influenced ecosystems are more open than expected for N-limited ecosystems. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 23240214-3 2012 Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0). Nitrates 8-15 CD59 molecule (CD59 blood group) Homo sapiens 62-68 23240214-3 2012 Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0). Nitrates 8-15 CD59 molecule (CD59 blood group) Homo sapiens 179-185 23240214-3 2012 Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0). Nitrates 140-147 CD59 molecule (CD59 blood group) Homo sapiens 62-68 22833666-6 2012 In contrast, an increased supply of nitrate stimulated NR activity and NO production, and enhanced SM and decreased SG levels in both genotypes. Nitrates 36-43 nitrate reductase 1 Arabidopsis thaliana 55-57 22715856-5 2012 The analysis was performed with the enzyme in its ligand-free and MgADP-complexed forms, as well as with the transition-state analogue abortive complex (MCK-Mg-ADP-creatine-nitrate ion). Nitrates 173-180 creatine kinase, M-type Homo sapiens 153-156 22778404-11 2012 Taken together, these data demonstrate that sialin mediates nitrate influx into salivary gland and other cell types. Nitrates 60-67 solute carrier family 17 member 5 Homo sapiens 44-50 22778404-12 2012 We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis. Nitrates 134-141 solute carrier family 17 member 5 Homo sapiens 57-63 22778404-12 2012 We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis. Nitrates 154-161 solute carrier family 17 member 5 Homo sapiens 57-63 22969780-3 2012 Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) - nitrate and nitrite - and oxidative stress in African-Americans is unknown. Nitrates 115-122 parathyroid hormone Homo sapiens 75-78 22687611-6 2012 These changes in nitrate treated mice were accompanied by increased expression of the Ca(2+) handling proteins calsequestrin 1 and the dihydropyridine receptor. Nitrates 17-24 calsequestrin 1 Mus musculus 111-126 22344735-9 2012 Taken together, this study has shown for first time that peroxynitrites can nitrate and activate MMP-2 and MMP-9 in the placenta, a nitrative pathway possibly related to MMPs overactivity in the placentas from type 2 diabetic patients. Nitrates 76-83 matrix metallopeptidase 9 Homo sapiens 107-112 22344735-9 2012 Taken together, this study has shown for first time that peroxynitrites can nitrate and activate MMP-2 and MMP-9 in the placenta, a nitrative pathway possibly related to MMPs overactivity in the placentas from type 2 diabetic patients. Nitrates 76-83 matrix metallopeptidase 2 Homo sapiens 170-174 22497785-4 2012 The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1). Nitrates 50-57 MuLV-induced myeloid leukemia 1 Mus musculus 108-114 22685171-1 2012 Nitrate reallocation to plant roots occurs frequently under adverse conditions and was recently characterized to be actively regulated by Nitrate Transporter1.8 (NRT1.8) in Arabidopsis (Arabidopsis thaliana) and implicated as a common response to stresses. Nitrates 0-7 NITRATE TRANSPORTER 1.8 Arabidopsis thaliana 138-160 22685171-1 2012 Nitrate reallocation to plant roots occurs frequently under adverse conditions and was recently characterized to be actively regulated by Nitrate Transporter1.8 (NRT1.8) in Arabidopsis (Arabidopsis thaliana) and implicated as a common response to stresses. Nitrates 0-7 NITRATE TRANSPORTER 1.8 Arabidopsis thaliana 162-168 22685171-5 2012 Further analyses showed that nitrate, as well as Na(+) and Cd(2+) levels, were significantly increased in nrt1.5 roots. Nitrates 29-36 nitrate transporter 1.1 Arabidopsis thaliana 106-110 22685171-8 2012 These data suggest that NRT1.5 is involved in nitrate allocation to roots and the consequent tolerance to several stresses, in a mechanism probably shared with NRT1.8. Nitrates 46-53 nitrate transporter 1.1 Arabidopsis thaliana 24-28 22497785-4 2012 The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1). Nitrates 50-57 MuLV-induced myeloid leukemia 1 Mus musculus 122-128 22497785-4 2012 The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1). Nitrates 91-98 MuLV-induced myeloid leukemia 1 Mus musculus 108-114 22497785-4 2012 The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1). Nitrates 91-98 MuLV-induced myeloid leukemia 1 Mus musculus 122-128 22572914-0 2012 Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Nitrates 8-15 nitric oxide synthase 3, endothelial cell Mus musculus 76-109 22588047-1 2012 Acute dietary nitrate (NO3-) supplementation has been reported to lower resting blood pressure, reduce the oxygen (O2) cost of sub-maximal exercise, and improve exercise tolerance. Nitrates 14-21 NBL1, DAN family BMP antagonist Homo sapiens 23-26 22572914-0 2012 Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Nitrates 8-15 xanthine dehydrogenase Mus musculus 114-137 22572914-7 2012 The beneficial effects of dietary nitrate and nitrite were reduced in mice lacking endothelial NO synthase or treated with the xanthine oxidoreductase inhibitor allopurinol. Nitrates 34-41 xanthine dehydrogenase Mus musculus 127-150 21932058-2 2012 The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group. Nitrates 267-274 arginine vasopressin Homo sapiens 125-136 22732219-4 2012 The addition of nitrate or ammonium resulted in a decrease or an increase in the expression of the same gene families, respectively, in both wild-type and siz1-2 mutants. Nitrates 16-23 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 155-159 22493305-0 2012 Transcriptional regulation of nitrate assimilation in Pseudomonas aeruginosa occurs via transcriptional antitermination within the nirBD-PA1779-cobA operon. Nitrates 30-37 assimilatory nitrate reductase Pseudomonas aeruginosa PAO1 137-143 22493305-1 2012 Bioinformatic approaches employed to analyse intergenic regions of Pseudomonas aeruginosa O1 (PAO1) for small RNAs (sRNAs) revealed a putative RNA gene encoded upstream of the nitrate assimilation operon nirBD-PA1779-cobA. Nitrates 176-183 assimilatory nitrate reductase Pseudomonas aeruginosa PAO1 210-216 22523192-0 2012 Overexpressing the ANR1 MADS-box gene in transgenic plants provides new insights into its role in the nitrate regulation of root development. Nitrates 102-109 AGAMOUS-like 44 Arabidopsis thaliana 19-23 22571503-0 2012 Nitrate transport in cucumber leaves is an inducible process involving an increase in plasma membrane H+-ATPase activity and abundance. Nitrates 0-7 plasma membrane ATPase 4 Cucumis sativus 86-111 22475571-7 2012 Nitrate and reactive oxygen species were greater in Salmonella-infected HD11 cells with the expression of iNOS and nuclear factor-kappaB by chicken macrophages infected with both systemic and broad host range serovars. Nitrates 0-7 nitric oxide synthase 2 Gallus gallus 106-110 22571503-10 2012 Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake. Nitrates 127-134 plasma membrane ATPase 4 Cucumis sativus 82-87 22571503-10 2012 Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake. Nitrates 127-134 high affinity nitrate transporter 2.4-like Cucumis sativus 93-97 22571503-10 2012 Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake. Nitrates 127-134 high affinity nitrate transporter 2.4-like Cucumis sativus 111-117 22571503-11 2012 At the leaf level, nitrate treatment modulated the expression of CsHA2, highlighting a main putative role of this isogene in the process. Nitrates 19-26 plasma membrane ATPase 4 Cucumis sativus 65-70 22406434-9 2012 Nitrate ingestion led to a rise in plasma nitrite together with an acute increase in CD34(+)/KDR(+) and CD133(+)/KDR(+)-CACs along with increased NOS-dependent vasodilation. Nitrates 0-7 CD34 antigen Mus musculus 85-89 22860400-4 2012 The per os administration of the NSE aqueous suspension in a dose of 50 mg/kg during 10 days to the rats with induced diabetes contributed to the normalization of catalase activity in the testis, which correlated with a decrease in the amount of TBA-reacting products and activity of superoxide dismutase and catalase in the blood plasma of animals; the use of NSE also contributed to the reduction of nitrite content in the gonads and to normalization of both nitrite and nitrate in the blood plasma of rats. Nitrates 473-480 enolase 2 Rattus norvegicus 33-36 22432443-0 2012 Nitrate transport capacity of the Arabidopsis thaliana NRT2 family members and their interactions with AtNAR2.1. Nitrates 0-7 nitrate transporter 2:1 Arabidopsis thaliana 55-59 22432443-1 2012 Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots. Nitrates 72-79 nitrate transporter 2:1 Arabidopsis thaliana 58-66 22432443-1 2012 Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots. Nitrates 72-79 nitrate transmembrane transporter Arabidopsis thaliana 134-142 22432443-1 2012 Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots. Nitrates 72-79 nitrate transporter 2:1 Arabidopsis thaliana 211-219 22432443-2 2012 Here, we have investigated interactions between the remaining AtNRT2 family members (AtNRT2.2 to AtNRT2.7) and AtNAR2.1, and their capacity for nitrate transport. Nitrates 144-151 nitrate transporter 2.2 Arabidopsis thaliana 85-93 22432443-2 2012 Here, we have investigated interactions between the remaining AtNRT2 family members (AtNRT2.2 to AtNRT2.7) and AtNAR2.1, and their capacity for nitrate transport. Nitrates 144-151 high affinity nitrate transporter 2.7 Arabidopsis thaliana 97-105 21786156-1 2012 Nitrate reductase is a key enzyme in the overall process of nitrate assimilation by plants. Nitrates 60-67 nitrate reductase [NADH]-like Cucumis sativus 0-17 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 35-42 regulatory particle triple-A ATPase 5A Arabidopsis thaliana 111-116 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 35-42 Tubulin/FtsZ family protein Arabidopsis thaliana 146-161 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 35-42 Tubulin/FtsZ family protein Arabidopsis thaliana 163-167 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 regulatory particle triple-A ATPase 5A Arabidopsis thaliana 111-116 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 Tubulin/FtsZ family protein Arabidopsis thaliana 146-161 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 Tubulin/FtsZ family protein Arabidopsis thaliana 163-167 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 regulatory particle triple-A ATPase 5A Arabidopsis thaliana 111-116 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 Tubulin/FtsZ family protein Arabidopsis thaliana 146-161 22329444-6 2012 Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively. Nitrates 199-206 Tubulin/FtsZ family protein Arabidopsis thaliana 163-167 22809160-7 2012 Moreover, darkness induced significant elevation of the POX activity that was prevented by the addition of nitrate to the growth medium. Nitrates 107-114 peroxidase-like Triticum aestivum 56-59 22809160-8 2012 It is proposed that the changes in light conditions result in the competition between nitrate- and ROS-metabolizing activities of POX in leaves, and a possible interaction between NR and POX controls the levels of NO and ROS in the leaf tissue. Nitrates 86-93 peroxidase-like Triticum aestivum 130-133 22799190-3 2012 This system is useful for simultaneous separation and determination of ammonium ion (NH4+), nitrite ion (NO2(-)), and nitrate ion (NO3(-)) in water samples. Nitrates 118-125 NBL1, DAN family BMP antagonist Homo sapiens 131-134 22192332-8 2012 RESULTS: High plasma levels of nitrite and nitrate (No2-/No3-) were observed in critically ill patients (mean level 78.92 mumol/l in sepsis and 97.20 mumol/l in septic shock). Nitrates 43-50 NBL1, DAN family BMP antagonist Homo sapiens 57-60 22248361-5 2012 Series 1 consistently inhibited the secretion of MMP-9 from TNFalpha/IL1beta stimulated Caco-2 cells at 10 muM, which could be attributed to NO related effects because the non-nitrate panel did not affect enzyme levels. Nitrates 176-183 matrix metallopeptidase 9 Homo sapiens 49-54 22263579-3 2012 In this study, we describe human and chicken sulfite oxidase variants in which the active site has been modified to alter substrate specificity and activity from sulfite oxidation to nitrate reduction. Nitrates 183-190 sulfite oxidase Gallus gallus 45-60 22246635-2 2012 This study shows that dissimilatory nitrate reduction to ammonium (DNRA) process, where nitrogen is not removed but instead recycled in the system, dominates nitrate reduction in low oxygen conditions (O(2) <110 muM), which have been persistent in the central Gulf of Finland during the past decade. Nitrates 36-43 latexin Homo sapiens 215-218 22246635-2 2012 This study shows that dissimilatory nitrate reduction to ammonium (DNRA) process, where nitrogen is not removed but instead recycled in the system, dominates nitrate reduction in low oxygen conditions (O(2) <110 muM), which have been persistent in the central Gulf of Finland during the past decade. Nitrates 158-165 latexin Homo sapiens 215-218 22434701-3 2012 The products of nitrite (NO(2) (-) ) oxidation by salivary peroxidase (SPO) and commercial bovine lactoperoxidase (LPO) are studied by utilizing an electrochemical assay that allows the direct, continuous monitoring of NO and/or NO(2) and by HPLC to assess nitrates at the end of the reaction. Nitrates 257-265 lactoperoxidase Homo sapiens 50-69 22434701-4 2012 Dialyzed saliva and LPO, in the presence of H(2) O(2) , convert nitrite into nitrate and form some NO, with a molar ratio of 10(3) . Nitrates 77-84 lactoperoxidase Bos taurus 20-23 22434701-8 2012 We conclude that SPO and LPO transform NO(2) (-) into nitrate-forming small amounts of NO in the presence of H(2) O(2) as an intermediate or a by-product, synthesized through the peroxynitrite pathway. Nitrates 54-61 lactoperoxidase Bos taurus 25-28 22219194-2 2012 In vitro studies reveal that MPO chlorinates and nitrates specific tyrosine residues of apoA-I, the major HDL protein. Nitrates 49-57 apolipoprotein A1 Homo sapiens 88-94 22263579-0 2012 Structure-based alteration of substrate specificity and catalytic activity of sulfite oxidase from sulfite oxidation to nitrate reduction. Nitrates 120-127 sulfite oxidase Gallus gallus 78-93 22263579-8 2012 The nitrate reducing ability of the human sulfite oxidase triple mutant was nearly 3-fold greater than that of the double mutant. Nitrates 4-11 sulfite oxidase Homo sapiens 42-57 22154340-7 2012 The fastest nitrate reduction by GR-F with Pt was achieved at pH 9 among 7.5 to 11. Nitrates 12-19 growth hormone releasing hormone Homo sapiens 33-37 22178413-5 2012 We show that leukocyte emigration in response to the proinflammatory chemokine MIP-2 is reduced by 70% after 7 days of dietary nitrate supplementation as well as by acute intravenous nitrite administration. Nitrates 127-134 C-X-C motif chemokine ligand 2 Rattus norvegicus 79-84 22178413-8 2012 In rats and mice subjected to a challenge with diclofenac, dietary nitrate prevented the increase in myeloperoxidase and P-selectin levels in small-intestinal tissue. Nitrates 67-74 myeloperoxidase Mus musculus 101-116 22178413-8 2012 In rats and mice subjected to a challenge with diclofenac, dietary nitrate prevented the increase in myeloperoxidase and P-selectin levels in small-intestinal tissue. Nitrates 67-74 selectin, platelet Mus musculus 121-131 22178413-9 2012 Antiseptic mouthwash, which eliminates oral nitrate reduction, markedly blunted the protective effect of dietary nitrate on P-selectin levels. Nitrates 113-120 selectin P Rattus norvegicus 124-134 22178413-11 2012 We conclude that dietary nitrate markedly reduces leukocyte recruitment to inflammation in a process involving attenuation of P-selectin and ICAM-1 upregulation. Nitrates 25-32 selectin P Rattus norvegicus 126-136 22178413-11 2012 We conclude that dietary nitrate markedly reduces leukocyte recruitment to inflammation in a process involving attenuation of P-selectin and ICAM-1 upregulation. Nitrates 25-32 intercellular adhesion molecule 1 Rattus norvegicus 141-147 21904872-1 2012 Members of the peptide transporter/nitrate transporter 1 (PTR/NRT1) family in plants transport a variety of substrates like nitrate, di- and tripepetides, auxin and carboxylates. Nitrates 35-42 nicotinamide riboside transporter Saccharomyces cerevisiae S288C 62-66 27009655-4 2012 Urease and glutamine synthetase (GS) activities varied with nitrogen source in a manner consistent with regulation by cellular nitrogen status via NtcA (rather than by external availability of nitrogen) in all three strains and indicated that each strain experienced some degree of nitrogen insufficiency during growth on nitrate. Nitrates 322-329 glutamate-ammonia ligase Homo sapiens 33-35 22307851-6 2012 Accordingly, transcriptomic and enzymatic analyses revealed a higher expression of genes involved in nitrate assimilation when lst8-1 mutants were shifted to long days. Nitrates 101-108 TOR complex subunit LST8 Saccharomyces cerevisiae S288C 127-131 22158677-0 2012 Regulation of high-affinity nitrate uptake in roots of Arabidopsis depends predominantly on posttranscriptional control of the NRT2.1/NAR2.1 transport system. Nitrates 28-35 nitrate transporter 2:1 Arabidopsis thaliana 127-133 22158677-1 2012 In Arabidopsis (Arabidopsis thaliana), the NRT2.1 gene codes for the main component of the root nitrate (NO(3)(-)) high-affinity transport system (HATS). Nitrates 96-103 nitrate transporter 2:1 Arabidopsis thaliana 43-49 22158760-2 2012 Nitrate Trasnporter2 (NRT2) gene family members are sentinels of nitrate availability. Nitrates 0-7 nitrate transporter 2:1 Arabidopsis thaliana 22-26 22158760-2 2012 Nitrate Trasnporter2 (NRT2) gene family members are sentinels of nitrate availability. Nitrates 65-72 nitrate transporter 2:1 Arabidopsis thaliana 22-26 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrates 77-84 monoamine oxidase A Homo sapiens 163-168 22293356-0 2012 Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice. Nitrates 37-44 interleukin 1 complex Mus musculus 15-28 22124705-1 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries. Nitrates 77-84 amine oxidase copper containing 2 Homo sapiens 223-227 22170613-8 2012 The estimated LODs for nitrite and nitrate in ninefold diluted plasma sample were 0.05 and 0.07 muM, respectively. Nitrates 35-42 latexin Homo sapiens 96-99 22170613-9 2012 The LODs for nitrite and nitrate in original plasma samples were 0.45 and 0.63 muM. Nitrates 25-32 latexin Homo sapiens 79-82 22506100-0 2012 Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress. Nitrates 103-110 heme oxygenase 1 Homo sapiens 0-16 22942686-1 2012 Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N(2) fixation, photorespiration or asparagine breakdown. Nitrates 104-111 glutamate-ammonia ligase Homo sapiens 0-20 22506100-4 2012 We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects. Nitrates 109-116 heme oxygenase 1 Homo sapiens 42-58 22506100-4 2012 We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects. Nitrates 109-116 heme oxygenase 1 Homo sapiens 60-64 22506100-6 2012 Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1(+/-) mice. Nitrates 33-40 heme oxygenase 1 Mus musculus 176-180 22506100-6 2012 Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1(+/-) mice. Nitrates 33-40 heme oxygenase 1 Mus musculus 243-247 22506100-8 2012 With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy. Nitrates 144-151 heme oxygenase 1 Homo sapiens 95-99 22227893-6 2012 In N-starved nrt2.4 mutants, nitrate uptake under low external supply and nitrate content in shoot phloem exudates was decreased. Nitrates 29-36 nitrate transporter 2:1 Arabidopsis thaliana 13-17 22055212-6 2012 We suggest that high light-induced changes in plasma membrane H(+)ATPase activity and transcription might have an adaptive role in sustaining the higher request for the nitrate resulting from increased photosynthate availability. Nitrates 169-176 membrane H(+)-ATPase 1 Zea mays 46-72 22227893-6 2012 In N-starved nrt2.4 mutants, nitrate uptake under low external supply and nitrate content in shoot phloem exudates was decreased. Nitrates 74-81 nitrate transporter 2:1 Arabidopsis thaliana 13-17 22227893-7 2012 In the absence of NRT2.1 and NRT2.2, loss of function of NRT2.4 (triple mutants) has an impact on biomass production under low nitrate supply. Nitrates 127-134 nitrate transporter 2.4 Arabidopsis thaliana 57-63 22880003-1 2012 The high affinity nitrate transport system in Arabidopsis thaliana involves one gene and potentially seven genes from the NRT1 and NRT2 family, respectively. Nitrates 18-25 nitrate transporter 1.1 Arabidopsis thaliana 122-126 22880003-1 2012 The high affinity nitrate transport system in Arabidopsis thaliana involves one gene and potentially seven genes from the NRT1 and NRT2 family, respectively. Nitrates 18-25 nitrate transporter 2:1 Arabidopsis thaliana 131-135 22880003-2 2012 Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes. Nitrates 84-91 nitrate transporter 2:1 Arabidopsis thaliana 12-18 22880003-2 2012 Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes. Nitrates 84-91 nitrate transporter 2:1 Arabidopsis thaliana 12-16 22880003-2 2012 Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes. Nitrates 84-91 nitrate transporter 2:1 Arabidopsis thaliana 20-24 22880003-2 2012 Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes. Nitrates 84-91 nitrate transporter 2:1 Arabidopsis thaliana 20-24 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 0-6 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 0-4 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 8-12 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 8-12 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 121-128 nitrate transporter 2:1 Arabidopsis thaliana 0-6 22880003-3 2012 NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole. Nitrates 121-128 nitrate transporter 2:1 Arabidopsis thaliana 0-4 22678215-4 2012 The presence of 0.01 mmol L(-1) phosphate, 0.2 mmol L(-1) silicate, and 1 mmol L(-1) nitrate greatly reduced the efficiency of SAR, illustrating the vulnerability of this technology in diverse geochemical settings. Nitrates 85-92 sarcosine dehydrogenase Homo sapiens 127-130 22829864-0 2012 Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation. Nitrates 63-71 dopa decarboxylase Mus musculus 20-24 22808220-9 2012 We propose a mechanism in which leptin activates NOS III and induces NO that nitrates PEPCK-C to reduce its level and glyceroneogenesis, therefore limiting FA re-esterification in WAT. Nitrates 77-85 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 86-93 22363694-4 2012 In marked contrast, the expressions of both mRNA and protein levels of inducible nitrate oxide synthase (iNOS) increased, and were accompanied by increased extracellular nitrate/nitrite production by Griess reaction. Nitrates 81-88 nitric oxide synthase 2 Homo sapiens 105-109 21818694-0 2011 Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites. Nitrates 35-43 aldehyde dehydrogenase 2 family member Homo sapiens 47-79 22439573-1 2011 The feasibility of hybrid systems for simultaneous removal of nitrate (NO3-) and ammonium ions (NH4+) from livestock wastewater was examined in batch experiments. Nitrates 62-69 NBL1, DAN family BMP antagonist Homo sapiens 71-74 21986532-5 2011 eNOS activity was determined by nitrite/nitrate accumulation, either via a fluorometric assay or by(15)N-nitrite or estimated (15)N(3)-citrulline concentrations when (15)N(4)-ARG was used to challenge the cells. Nitrates 40-47 nitric oxide synthase 3 Homo sapiens 0-4 21251210-9 2011 Three mitochondrial antioxidant enzymes were altered by DOX, i.e. up-regulation of manganese superoxide dismutase and peroxiredoxin 3 (Prx3), and down-regulation of Prx5, which were reversed by nitrate. Nitrates 194-201 peroxiredoxin 3 Mus musculus 118-133 22320098-1 2011 A reusable catalytic reductor consisting of 96 copperized-cadmium pins attached to a microplate lid was developed to simultaneously reduce nitrate (NO3-) to nitrite (NO2-) in all wells of a standard microplate. Nitrates 139-146 NBL1, DAN family BMP antagonist Homo sapiens 148-151 21251210-9 2011 Three mitochondrial antioxidant enzymes were altered by DOX, i.e. up-regulation of manganese superoxide dismutase and peroxiredoxin 3 (Prx3), and down-regulation of Prx5, which were reversed by nitrate. Nitrates 194-201 peroxiredoxin 3 Mus musculus 135-139 22187853-3 2011 A directly proportionate relationship was seen between methemoglobin level in the blood and nitrate ingestion. Nitrates 92-99 hemoglobin subunit gamma 2 Homo sapiens 55-68 21862482-3 2011 Due to its localization exactly at the peak of this QTL, the putative NRT1-NO(3)(-) transporter (Medtr5g093170.1), closely related to Arabidopsis AtNRT1.3, a putative low-affinity nitrate transporter, appeared to be a significant candidate involved in the control of primary root growth and NO(3)(-) sensing. Nitrates 180-187 nitrate transporter 1.1 Arabidopsis thaliana 70-74 21765367-1 2011 PURPOSE: Hemodynamic nitrate tolerance has been shown to result in an insulin-resistant state. Nitrates 21-28 insulin Oryctolagus cuniculus 70-77 21765367-3 2011 METHODS: Changes in insulin sensitivity in response to feeding in conscious rabbits were determined by rapid insulin sensitivity test, in both nitrate-tolerant and nitrate-intolerant animals. Nitrates 143-150 insulin Oryctolagus cuniculus 20-27 21765367-3 2011 METHODS: Changes in insulin sensitivity in response to feeding in conscious rabbits were determined by rapid insulin sensitivity test, in both nitrate-tolerant and nitrate-intolerant animals. Nitrates 164-171 insulin Oryctolagus cuniculus 20-27 21765367-8 2011 CONCLUSIONS: Nitrate tolerance blocks both the meal-induced insulin sensitization phenomenon and the insulin-sensitizing effect of intraportal CCK. Nitrates 13-20 insulin Oryctolagus cuniculus 60-67 21765367-8 2011 CONCLUSIONS: Nitrate tolerance blocks both the meal-induced insulin sensitization phenomenon and the insulin-sensitizing effect of intraportal CCK. Nitrates 13-20 cholecystokinin Oryctolagus cuniculus 143-146 21949212-0 2011 Dissecting the role of CHITINASE-LIKE1 in nitrate-dependent changes in root architecture. Nitrates 42-49 Chitinase family protein Arabidopsis thaliana 23-38 21914816-6 2011 In ineffective nodules and in nodules fed with nitrate, two conditions in which nitrogen fixation is impaired and GS activity is reduced, a significant increase in nodule GS nitration levels was observed. Nitrates 47-54 LOC11405318 Medicago truncatula 114-116 21949212-1 2011 The root phenotype of an Arabidopsis (Arabidopsis thaliana) mutant of CHITINASE-LIKE1 (CTL1), called arm (for anion-related root morphology), was previously shown to be conditional on growth on high nitrate, chloride, or sucrose. Nitrates 199-206 Chitinase family protein Arabidopsis thaliana 70-85 21949212-1 2011 The root phenotype of an Arabidopsis (Arabidopsis thaliana) mutant of CHITINASE-LIKE1 (CTL1), called arm (for anion-related root morphology), was previously shown to be conditional on growth on high nitrate, chloride, or sucrose. Nitrates 199-206 Chitinase family protein Arabidopsis thaliana 87-91 21949212-10 2011 Interestingly, eto2 and eto3 ethylene overproduction mutants mimicked some of the conditional root characteristics of the arm mutant on high nitrate. Nitrates 141-148 ACC synthase 5 Arabidopsis thaliana 15-19 21949212-10 2011 Interestingly, eto2 and eto3 ethylene overproduction mutants mimicked some of the conditional root characteristics of the arm mutant on high nitrate. Nitrates 141-148 1-aminocyclopropane-1-carboxylate synthase 9 Arabidopsis thaliana 24-28 21844097-2 2011 Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1 (HO-1). Nitrates 21-28 heme oxygenase 1 Homo sapiens 110-126 21907028-4 2011 The nitrate system featured a limit of detection of 0.04 mg N L(-1), 0.4%RSD (1 mg N L(-1) as nitrate, n=10), a coefficient of determination (R(2)) of 0.9995 over the calibration range 0.0-2.0 mg N L(-1), and a data acquisition time of 1.5s per spectrum. Nitrates 4-11 nuclear receptor subfamily 4 group A member 1 Homo sapiens 103-107 22073628-2 2011 Nitrate (NO3-) is the form of reactive N that is most susceptible to leaching and runoff; thus, a more thorough understanding of nitrification and NO3(-) availability is needed if we are to accurately predict the consequences of residential expansion for water quality. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 22073628-2 2011 Nitrate (NO3-) is the form of reactive N that is most susceptible to leaching and runoff; thus, a more thorough understanding of nitrification and NO3(-) availability is needed if we are to accurately predict the consequences of residential expansion for water quality. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 147-150 21844097-2 2011 Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1 (HO-1). Nitrates 21-28 heme oxygenase 1 Homo sapiens 128-132 21915898-6 2011 The deshieldings on H-3a, H-5a and the ortho protons of the phenyl groups are less in the nitrate and picrate than in the corresponding hydrochloride. Nitrates 90-97 H3 clustered histone 1 Homo sapiens 20-24 21407132-8 2011 Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031). Nitrates 0-7 CD59 molecule (CD59 blood group) Homo sapiens 81-87 21407132-8 2011 Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031). Nitrates 0-7 CD59 molecule (CD59 blood group) Homo sapiens 115-121 21407132-8 2011 Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031). Nitrates 0-7 CD59 molecule (CD59 blood group) Homo sapiens 115-121 21407132-8 2011 Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031). Nitrates 0-7 CD59 molecule (CD59 blood group) Homo sapiens 115-121 21407132-8 2011 Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031). Nitrates 56-63 CD59 molecule (CD59 blood group) Homo sapiens 81-87 21915898-8 2011 These observations suggest that the nitrates and pictrate exist as ion pairs in DMSO-d(6) and the nitrate and picrate ions shield, H-3a, H-5a and the ortho protons by magnetic anistropic effect. Nitrates 36-44 H3 clustered histone 1 Homo sapiens 131-135 21915898-8 2011 These observations suggest that the nitrates and pictrate exist as ion pairs in DMSO-d(6) and the nitrate and picrate ions shield, H-3a, H-5a and the ortho protons by magnetic anistropic effect. Nitrates 36-43 H3 clustered histone 1 Homo sapiens 131-135 21762167-7 2011 Our findings, in addition to strengthening already known mechanisms, revealed the existence of a new complex signaling framework in which brassinosteroids (BRI1), the module MKK2-MAPK6 and the fine regulation of nitric oxide homeostasis via the co-expression of synthetic (nitrate reductase) and scavenging (hemoglobin) components may play key functions in maize responses to nitrate. Nitrates 273-280 non-symbiotic hemoglobin Zea mays 308-318 21984695-4 2011 Separable fragments of RIN4, including those produced when the T3E AvrRpt2 cleaves RIN4 and each containing a plant-specific nitrate-induced (NOI) domain, suppress PTI. Nitrates 125-132 RPM1 interacting protein 4 Arabidopsis thaliana 23-27 21506955-1 2011 BACKGROUND AND PURPOSE: Recent studies have suggested an essential role for aldehyde dehydrogenase 2 (ALDH2) in the bioactivation of organic nitrates such as glyceryl trinitrate (GTN). Nitrates 141-149 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 76-100 21327803-11 2011 RDX biodegradation activity by the T7 isolate was inhibited in the presence of nitrate or ammonium concentrations above 1.6 and 5.5 mM, respectively (100 mg l(-1)) while the T9N isolate"s activity was retarded only by ammonium concentrations above 5.5 mM. Nitrates 79-86 radixin Homo sapiens 0-3 21327803-13 2011 RDX-degrading activity by the Rhodococcus species isolate T9N may have important implications for the bioremediation of nitrate-rich RDX-contaminated aquifers. Nitrates 120-127 radixin Homo sapiens 0-3 21327803-13 2011 RDX-degrading activity by the Rhodococcus species isolate T9N may have important implications for the bioremediation of nitrate-rich RDX-contaminated aquifers. Nitrates 120-127 radixin Homo sapiens 133-136 21506955-1 2011 BACKGROUND AND PURPOSE: Recent studies have suggested an essential role for aldehyde dehydrogenase 2 (ALDH2) in the bioactivation of organic nitrates such as glyceryl trinitrate (GTN). Nitrates 141-149 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 102-107 21728895-15 2011 Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate. Nitrates 70-77 nuclear RNA export factor 1 Homo sapiens 95-98 21642046-7 2011 RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002). Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 67-70 21642046-7 2011 RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002). Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 104-107 21642046-7 2011 RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002). Nitrates 54-61 NBL1, DAN family BMP antagonist Homo sapiens 104-107 21728895-15 2011 Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate. Nitrates 143-150 nuclear RNA export factor 1 Homo sapiens 95-98 21543107-1 2011 INTRODUCTION: Despite experimental evidences of the influence of the aging suppressor gene Klotho, on the modulation of endothelial nitric oxide synthase (eNOS) activity and nitric oxide (NO) production, the contribution of its variants to the phenotypic variance of plasma nitrite and nitrate (NO(x)) has not been addressed to date. Nitrates 286-293 klotho Homo sapiens 91-97 21777567-2 2011 The genes for nitrate reductase (NR) and nitrite reductase (NIR), which are enzymes in the nitrate assimilation pathway, are typical nitrate-inducible genes. Nitrates 14-21 nitrite reductase 1 Arabidopsis thaliana 60-63 21777567-2 2011 The genes for nitrate reductase (NR) and nitrite reductase (NIR), which are enzymes in the nitrate assimilation pathway, are typical nitrate-inducible genes. Nitrates 91-98 nitrite reductase 1 Arabidopsis thaliana 60-63 21777567-3 2011 We previously identified the first authentic nitrate-responsive cis-element (NRE) for nitrate-inducible transcription by the analysis of the NIR gene promoter from Arabidopsis. Nitrates 45-52 nitrite reductase 1 Arabidopsis thaliana 141-144 21777567-3 2011 We previously identified the first authentic nitrate-responsive cis-element (NRE) for nitrate-inducible transcription by the analysis of the NIR gene promoter from Arabidopsis. Nitrates 86-93 nitrite reductase 1 Arabidopsis thaliana 141-144 21777567-6 2011 Second, we show that NRE-like sequences are present in various dicotyledonous and monocotyledonous NIR gene promoters at similar positions and that they also drive nitrate-inducible expression in Arabidopsis. Nitrates 164-171 nitrite reductase 1 Arabidopsis thaliana 99-102 21708390-4 2011 Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively. Nitrates 83-90 latexin Homo sapiens 129-132 21652715-1 2011 Ynt1, the single high affinity nitrate and nitrite transporter of the yeast Hansenula polymorpha, is regulated by the quality of nitrogen sources. Nitrates 31-38 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 0-4 21652715-6 2011 As a result, in this strain Ynt1 is sorted to the vacuole, from both plasma membrane and the later biosynthetic pathway in nitrogen-free conditions and nitrate. Nitrates 152-159 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 28-32 21554376-9 2011 Levels of nitrite and nitrate (NO(x)), as an index of nitric oxide, bioavailability were significantly decreased in the iNOS(-/-) diabetic mouse heart. Nitrates 22-29 nitric oxide synthase 2, inducible Mus musculus 120-124 21708390-4 2011 Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively. Nitrates 83-90 latexin Homo sapiens 129-132 21486304-3 2011 A two-component system for nitrate transport including NRT2s with a partner protein (NAR2 or NRT3.1) has been identified in Arabidopsis. Nitrates 27-34 nitrate transporter 2:1 Arabidopsis thaliana 55-59 21486304-3 2011 A two-component system for nitrate transport including NRT2s with a partner protein (NAR2 or NRT3.1) has been identified in Arabidopsis. Nitrates 27-34 nitrate transmembrane transporter Arabidopsis thaliana 93-99 22097361-4 2011 Ammonium nitrogen deposition had larger effects on soil NH4+ -N content, nitrate nitrogen deposition had larger effects on soil NO3- -N content, while mixed ammonium and nitrate nitrogen deposition increased the contents of both soil NH4+ -N and soil NO3- -N, and the increments were higher than those of ammonium nitrogen deposition and nitrate nitrogen deposition, suggesting the additive effects of the mixed ammonium and nitrate nitrogen deposition on the forest soil available N. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 128-131 21696799-1 2011 Denitrifying woodchip bioreactors (denitrification beds) are increasingly used to remove excess nitrate (NO3-) from point-sources such as wastewater effluent or subsurface drains from agricultural fields. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 105-108 22097361-4 2011 Ammonium nitrogen deposition had larger effects on soil NH4+ -N content, nitrate nitrogen deposition had larger effects on soil NO3- -N content, while mixed ammonium and nitrate nitrogen deposition increased the contents of both soil NH4+ -N and soil NO3- -N, and the increments were higher than those of ammonium nitrogen deposition and nitrate nitrogen deposition, suggesting the additive effects of the mixed ammonium and nitrate nitrogen deposition on the forest soil available N. Nitrates 170-177 NBL1, DAN family BMP antagonist Homo sapiens 251-254 21772271-5 2011 Decreased nitrate reductase activity in siz1-2 plants resulted in low nitrogen concentrations, low nitric oxide production and high nitrate content in comparison with wild-type plants. Nitrates 10-17 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 40-44 21754669-1 2011 In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions. Nitrates 236-243 mitochondrially encoded cytochrome c oxidase II Homo sapiens 69-75 21762512-10 2011 Addition of TN-C induced IL-6, PGE2, and nitrate release and upregulated ADAMTS4 mRNA in cultured primary human and bovine chondrocytes. Nitrates 41-48 tenascin C Homo sapiens 12-16 21424691-5 2011 Genetic and biochemical analyses identified the essential nitrate/nitrite assimilation functions of the encoded proteins, orderly, the assimilatory nitrate reductase catalytic subunit (NasA), nitrate reductase electron transfer subunit (NasC), nitrate/nitrite transporter (NasK), assimilatory nitrite reductase large subunit (NasB) and small subunit (NasD), bifunctional uroporphyrinogen-III synthase (NasE), and an unknown function protein (NasF). Nitrates 58-65 uroporphyrinogen-III synthase Amycolatopsis mediterranei U32 371-400 21446951-1 2011 The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen. Nitrates 91-98 histocompatibility minor 13 Homo sapiens 37-40 21228891-9 2011 Our results suggest that the AOA, not the AOB, were contributing to nitrate leaching at the site by providing substrate for the nitrite oxidizers. Nitrates 68-75 aprataxin Homo sapiens 29-32 21334141-7 2011 BBS-2 significantly reduced the increases in lung lymph nitrite/nitrate (10 +- 3 muM vs. 26 +- 6 muM in controls, p < 0.05) and 3-nitrotyrosine (109 +- 11 (densitometry value) vs. 151 +- 18 in controls, p < 0.05). Nitrates 64-71 Bardet-Biedl syndrome 2 protein Ovis aries 0-5 21657847-1 2011 AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated. Nitrates 199-206 myeloperoxidase Homo sapiens 40-55 21657847-1 2011 AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated. Nitrates 199-206 myeloperoxidase Homo sapiens 57-60 21421215-8 2011 Coexisting anions such as sulfate, nitrate, chloride, carbonate, and humic acid could decrease the sensitivity of the SERS analysis. Nitrates 35-42 seryl-tRNA synthetase 1 Homo sapiens 118-122 21593598-2 2011 In a recent work, we have revealed MPK6 could phosphorylate Arabidopsis NIA2 at the serine 627 in hinge 2 region, this phosporylation may represent a rapid activation mechnism when plant need excessive nitrate reduction. Nitrates 202-209 MAP kinase 6 Arabidopsis thaliana 35-39 21593598-2 2011 In a recent work, we have revealed MPK6 could phosphorylate Arabidopsis NIA2 at the serine 627 in hinge 2 region, this phosporylation may represent a rapid activation mechnism when plant need excessive nitrate reduction. Nitrates 202-209 nitrate reductase 2 Arabidopsis thaliana 72-76 21586729-4 2011 SLAH3 (SLAC1 homolog 3) was also present in guard cells, and coexpression of SLAH3 with the calcium ion (Ca2+)-dependent kinase CPK21 in Xenopus oocytes mediated nitrate-induced anion currents. Nitrates 162-169 C4-dicarboxylate transporter/malic acid transport protein Arabidopsis thaliana 7-12 21754318-1 2011 In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions. Nitrates 209-216 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-69 20559710-8 2011 High nitrate levels may have already affected public health based on limited sampling for methemoglobin. Nitrates 5-12 hemoglobin subunit gamma 2 Homo sapiens 90-103 20518849-7 2011 Intact MLC1 levels, measured by 2D gel electrophoresis and immunoblot, were shown to decrease with increasing duration of ischemia, which correlated with increasing levels of nitrotyrosine and nitrite/nitrate. Nitrates 201-208 myosin light chain 1 Homo sapiens 7-11 21480587-4 2011 delta15N(NO3) and delta18O(NO3) of catchment surface water and groundwater samples revealed a dominant influence from microbially cycled and nitrified source-nitrogen, which results in high nitrate concentrations in Chalk groundwater and upstream in the River Wensum. Nitrates 190-197 NBL1, DAN family BMP antagonist Homo sapiens 27-30 21448006-1 2011 NRT1.1 is a dual-affinity nitrate transporter and a nitrate sensor that plays a role in nitrate-dependent signaling pathway. Nitrates 26-33 immunoglobulin superfamily member 9 Homo sapiens 0-4 21052766-0 2011 Evidence for a nitrate-independent function of the nitrate sensor NRT1.1 in Arabidopsis thaliana. Nitrates 15-22 nitrate transporter 1.1 Arabidopsis thaliana 66-72 21052766-0 2011 Evidence for a nitrate-independent function of the nitrate sensor NRT1.1 in Arabidopsis thaliana. Nitrates 51-58 nitrate transporter 1.1 Arabidopsis thaliana 66-72 21052766-1 2011 NRT1.1 is a putative nitrate sensor and is involved in many nitrate-dependent responses. Nitrates 21-28 nitrate transporter 1.1 Arabidopsis thaliana 0-6 21052766-1 2011 NRT1.1 is a putative nitrate sensor and is involved in many nitrate-dependent responses. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 0-6 21052766-2 2011 On the other hand, a nitrate-independent function of NRT1.1 has been implied, but the clear-cut evidence is unknown. Nitrates 21-28 nitrate transporter 1.1 Arabidopsis thaliana 53-59 21052766-4 2011 This unique phenotype was not observed in mutants of NLP7, which has been suggested to play a role in the nitrate-dependent signaling pathway. Nitrates 106-113 NIN like protein 7 Arabidopsis thaliana 53-57 21052766-5 2011 Our real-time PCR analysis, and evidence from a literature survey revealed that several genes relevant to the aliphatic glucosinolate-biosynthetic pathway were regulated via a nitrate-independent signal from NRT1.1. Nitrates 176-183 nitrate transporter 1.1 Arabidopsis thaliana 208-214 21052766-6 2011 When taken together, the present study strongly suggests the existence of a nitrate-independent function of NRT1.1. Nitrates 76-83 nitrate transporter 1.1 Arabidopsis thaliana 108-114 21448006-1 2011 NRT1.1 is a dual-affinity nitrate transporter and a nitrate sensor that plays a role in nitrate-dependent signaling pathway. Nitrates 52-59 immunoglobulin superfamily member 9 Homo sapiens 0-4 21448006-2 2011 Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1. Nitrates 130-137 immunoglobulin superfamily member 9 Homo sapiens 36-40 21571952-0 2011 Arabidopsis nitrate transporter NRT1.9 is important in phloem nitrate transport. Nitrates 12-19 nitrate transporter 1.1 Arabidopsis thaliana 32-36 21571952-1 2011 This study of the Arabidopsis thaliana nitrate transporter NRT1.9 reveals an important function for a NRT1 family member in phloem nitrate transport. Nitrates 39-46 nitrate transporter 1.1 Arabidopsis thaliana 59-63 21448006-2 2011 Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1. Nitrates 157-164 immunoglobulin superfamily member 9 Homo sapiens 36-40 21571952-1 2011 This study of the Arabidopsis thaliana nitrate transporter NRT1.9 reveals an important function for a NRT1 family member in phloem nitrate transport. Nitrates 39-46 nitrate transporter 1.1 Arabidopsis thaliana 102-106 21448006-2 2011 Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1. Nitrates 157-164 immunoglobulin superfamily member 9 Homo sapiens 189-193 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 19-26 nitrate transporter 1.1 Arabidopsis thaliana 3-7 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 19-26 nitrate transporter 1.1 Arabidopsis thaliana 134-138 21448006-3 2011 Detailed underlying mechanisms for the ammonium/low pH-tolerance of the NRT1.1 mutants will be revealed by paying attention to auxin behavior, phosphorylated status of NRT1.1 and other components related to the primary nitrate response and nitrate transport. Nitrates 219-226 immunoglobulin superfamily member 9 Homo sapiens 72-76 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 3-7 21448006-3 2011 Detailed underlying mechanisms for the ammonium/low pH-tolerance of the NRT1.1 mutants will be revealed by paying attention to auxin behavior, phosphorylated status of NRT1.1 and other components related to the primary nitrate response and nitrate transport. Nitrates 240-247 immunoglobulin superfamily member 9 Homo sapiens 72-76 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 134-138 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 3-7 21454300-0 2011 The regulatory region controlling the nitrate-responsive expression of a nitrate reductase gene, NIA1, in Arabidopsis. Nitrates 38-45 nitrate reductase 1 Arabidopsis thaliana 73-90 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 134-138 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 3-7 21571952-4 2011 In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots. Nitrates 87-94 nitrate transporter 1.1 Arabidopsis thaliana 134-138 21571952-5 2011 Under high nitrate conditions, the nrt1.9 mutant showed enhanced root-to-shoot nitrate transport and plant growth. Nitrates 11-18 nitrate transporter 1.1 Arabidopsis thaliana 35-39 21571952-5 2011 Under high nitrate conditions, the nrt1.9 mutant showed enhanced root-to-shoot nitrate transport and plant growth. Nitrates 79-86 nitrate transporter 1.1 Arabidopsis thaliana 35-39 21571952-6 2011 We conclude that phloem nitrate transport is facilitated by expression of NRT1.9 in root companion cells. Nitrates 24-31 Major facilitator superfamily protein Arabidopsis thaliana 74-80 21571952-7 2011 In addition, enhanced root-to-shoot xylem transport of nitrate in nrt1.9 mutants points to a negative correlation between xylem and phloem nitrate transport. Nitrates 55-62 nitrate transporter 1.1 Arabidopsis thaliana 66-70 21571952-7 2011 In addition, enhanced root-to-shoot xylem transport of nitrate in nrt1.9 mutants points to a negative correlation between xylem and phloem nitrate transport. Nitrates 139-146 nitrate transporter 1.1 Arabidopsis thaliana 66-70 21454300-0 2011 The regulatory region controlling the nitrate-responsive expression of a nitrate reductase gene, NIA1, in Arabidopsis. Nitrates 38-45 nitrate reductase 1 Arabidopsis thaliana 97-101 21454300-1 2011 Nitrate reductase (NR) is the enzyme that catalyzes the first step of nitrate assimilation. Nitrates 70-77 nitrate reductase 1 Arabidopsis thaliana 0-17 21454300-1 2011 Nitrate reductase (NR) is the enzyme that catalyzes the first step of nitrate assimilation. Nitrates 70-77 nitrate reductase 1 Arabidopsis thaliana 19-21 21454300-2 2011 It is well known that the expression of NR genes is rapidly induced in various plants by nitrate. Nitrates 89-96 nitrate reductase 1 Arabidopsis thaliana 40-42 21454300-4 2011 This cast some doubt on the role of the NR gene promoter in the nitrate-inducible expression of this gene. Nitrates 64-71 nitrate reductase 1 Arabidopsis thaliana 40-42 21454300-9 2011 We also show that the 2.7 kb promoter sequence of NIA2, another NR gene of Arabidopsis, cannot direct nitrate-inducible expression. Nitrates 102-109 nitrate reductase 2 Arabidopsis thaliana 50-54 21239382-4 2011 In Arabidopsis, increasing evidence suggests that, for nitrate, the main nitrogen source for most plant species, a major sensor is the NRT1.1 nitrate transporter, also contributing to nitrate uptake by the roots. Nitrates 55-62 nicotinamide riboside transporter Saccharomyces cerevisiae S288C 135-139 21584187-3 2011 Ferredoxin-nitrite reductase (NiR) catalyses the reduction of nitrite to ammonium in the second step of the nitrate- assimilation pathway. Nitrates 108-115 nitrite reductase 1 Arabidopsis thaliana 0-28 21584187-3 2011 Ferredoxin-nitrite reductase (NiR) catalyses the reduction of nitrite to ammonium in the second step of the nitrate- assimilation pathway. Nitrates 108-115 nitrite reductase 1 Arabidopsis thaliana 30-33 21239382-4 2011 In Arabidopsis, increasing evidence suggests that, for nitrate, the main nitrogen source for most plant species, a major sensor is the NRT1.1 nitrate transporter, also contributing to nitrate uptake by the roots. Nitrates 142-149 nicotinamide riboside transporter Saccharomyces cerevisiae S288C 135-139 21239382-7 2011 The various facets, as well as the mechanisms of nitrate sensing by NRT1.1 are considered, and the possible occurrence of other nitrate transceptors is discussed. Nitrates 49-56 nicotinamide riboside transporter Saccharomyces cerevisiae S288C 68-72 21450100-9 2011 CSF Nitrate levels were detected using the Griess reagent. Nitrates 4-11 colony stimulating factor 2 Homo sapiens 0-3 21470979-1 2011 Various human-induced changes to the atmosphere have caused carbon dioxide (CO2), nitrogen dioxide (NO2) and nitrate deposition (NO3-) to increase in many regions of the world. Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 129-132 21252222-3 2011 Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance. Nitrates 70-78 aldehyde dehydrogenase 2 family member Homo sapiens 145-151 21450087-3 2011 RESULTS: The expression of the nap genes, nrfA, cymA and hcp was significantly reduced in etrA deletion mutant EtrA7-1; however, limited anaerobic growth and nitrate reduction occurred, suggesting that multiple regulators control nitrate reduction in this strain. Nitrates 230-237 hydroxylamine reductase Shewanella oneidensis MR-1 57-60 21252222-3 2011 Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance. Nitrates 70-77 aldehyde dehydrogenase 2 family member Homo sapiens 145-151 21252222-3 2011 Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance. Nitrates 185-192 aldehyde dehydrogenase 2 family member Homo sapiens 145-151 21156214-2 2011 A possible mechanism may involve nitrate-mediated activation of various extracellular matrix (ECM) proteases, particularly matrix metalloproteinase-9 (MMP-9), and adhesion molecules in human macrophages, leading to the destabilization of atherosclerotic plaques. Nitrates 33-40 matrix metallopeptidase 9 Homo sapiens 123-149 21156214-2 2011 A possible mechanism may involve nitrate-mediated activation of various extracellular matrix (ECM) proteases, particularly matrix metalloproteinase-9 (MMP-9), and adhesion molecules in human macrophages, leading to the destabilization of atherosclerotic plaques. Nitrates 33-40 matrix metallopeptidase 9 Homo sapiens 151-156 21193589-5 2011 The expression of inducible nitric oxide (NO) synthase (iNOS) mRNA was increased in the vascular tissues isolated from BDL rats, and accordingly, nitrate/nitrite production was increased. Nitrates 146-153 nitric oxide synthase 2 Rattus norvegicus 56-60 21520758-6 2011 Low nitrate (NO3-) concentrations (0.2-0.4 mg NO3- -NL(-1)) in the shallow groundwater of the cropping system were associated with low rates of mineralization and nitrification (33 kg N ha(-1) yr(-1)) and high grass seed crop uptake of N (155 kg N ha(-1) yr(-1)). Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 13-16 21445844-8 2011 During oxygenation of nitric oxide to nitrate, oxidized ferric hemoglobin is formed (methemoglobin), which can be reduced by an associated reductase. Nitrates 38-45 hemoglobin subunit gamma 2 Homo sapiens 85-98 21304405-7 2011 In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Nitrates 126-133 interleukin 2 Mus musculus 89-93 21304405-7 2011 In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model. Nitrates 126-133 interleukin 2 Mus musculus 89-93 21520758-6 2011 Low nitrate (NO3-) concentrations (0.2-0.4 mg NO3- -NL(-1)) in the shallow groundwater of the cropping system were associated with low rates of mineralization and nitrification (33 kg N ha(-1) yr(-1)) and high grass seed crop uptake of N (155 kg N ha(-1) yr(-1)). Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 46-49 20938379-12 2011 Significant decreases in plasma nitrate/nitrite after injury were associated with increased lung ADMA concentrations and decreased DDAH-2 expression. Nitrates 32-39 dimethylarginine dimethylaminohydrolase 2 Homo sapiens 131-137 21329998-11 2011 In addition, genes involved in nitrate dissimilation (nre, nar, nir), catalase (kat), or superoxide dismutase (sod) were well detected. Nitrates 31-38 superoxide dismutase Staphylococcus equorum 89-109 21455488-0 2011 Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in arabidopsis. Nitrates 58-65 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 22-25 21455488-10 2011 Also the Pi overaccumulator pho2 mutant shows Pi toxicity in a nitrate-dependent manner similar to the nla mutant. Nitrates 63-70 phosphate 2 Arabidopsis thaliana 28-32 21455488-12 2011 The results demonstrate that NLA and miR827 have pivotal roles in regulating Pi homeostasis in plants in a nitrate-dependent fashion. Nitrates 107-114 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 29-32 21455488-12 2011 The results demonstrate that NLA and miR827 have pivotal roles in regulating Pi homeostasis in plants in a nitrate-dependent fashion. Nitrates 107-114 MIR827 Arabidopsis thaliana 37-43 20300837-0 2011 Nitrate levels modulate denitrification activity in tropical mangrove sediments (Goa, India). Nitrates 0-7 tripartite motif containing 47 Homo sapiens 81-84 20237835-6 2011 Nitrate (as NO3-) contamination has appeared as another anthropogenic threat to some intensively cultivable rural habitations of this region. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 12-15 21036778-8 2011 The use of BNP levels, in conjunction with other clinical information, significantly increased the detection of HF in combination with an additional diagnosis (32 vs. 16%, P = 0.001) and also increased the application of HF-specific medical therapy (nitrates: 32 vs. 23%, P < 0.05 and diuretics: 65 vs. 50%, P < 0.01). Nitrates 250-258 natriuretic peptide B Homo sapiens 11-14 20959627-0 2011 The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting. Nitrates 140-147 hypothetical protein Arabidopsis thaliana 14-34 20959627-0 2011 The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting. Nitrates 140-147 hypothetical protein Arabidopsis thaliana 35-41 20959627-11 2011 Altogether the results suggest that GLN1;2 is essential for nitrogen assimilation under ample nitrate supply and for ammonium detoxification. Nitrates 94-101 hypothetical protein Arabidopsis thaliana 36-42 20959627-3 2011 GLN1;2 is the most highly expressed in leaves and is over-expressed in roots by ammonium supply and in rosettes by ample nitrate supply compared with limiting nitrate supply. Nitrates 121-128 hypothetical protein Arabidopsis thaliana 0-6 20959627-3 2011 GLN1;2 is the most highly expressed in leaves and is over-expressed in roots by ammonium supply and in rosettes by ample nitrate supply compared with limiting nitrate supply. Nitrates 159-166 hypothetical protein Arabidopsis thaliana 0-6 20959627-10 2011 Growing plants in vitro with ammonium or nitrate as the sole nitrogen source allowed us to confirm that GLN1;2 is induced by ammonium in roots and to observe that gln1;2 mutants displayed, under such conditions, longer root hair and smaller rosette phenotypes in ammonium. Nitrates 41-48 hypothetical protein Arabidopsis thaliana 104-110 20959627-10 2011 Growing plants in vitro with ammonium or nitrate as the sole nitrogen source allowed us to confirm that GLN1;2 is induced by ammonium in roots and to observe that gln1;2 mutants displayed, under such conditions, longer root hair and smaller rosette phenotypes in ammonium. Nitrates 41-48 hypothetical protein Arabidopsis thaliana 163-169 21112616-8 2011 For the Salburua wetland riparian soil, we estimated a potential nitrate removal capacity of 1012 kg N-NO3-ha-1 year-1, and potential greenhouse gas emissions of 5620 kg CO2 ha-1 year-1 and 240 kg N-N2O ha-1 year-1. Nitrates 65-72 NBL1, DAN family BMP antagonist Homo sapiens 103-106 21193579-3 2011 Nitrate transporters (NRT) from the NRT1 and NRT2 families ensure the capacity of root cells to take up nitrate, through high- and low-affinity systems (HATS and LATS) depending on nitrate concentrations in the soil solution. Nitrates 104-111 immunoglobulin superfamily member 9 Homo sapiens 36-40 21193579-3 2011 Nitrate transporters (NRT) from the NRT1 and NRT2 families ensure the capacity of root cells to take up nitrate, through high- and low-affinity systems (HATS and LATS) depending on nitrate concentrations in the soil solution. Nitrates 181-188 immunoglobulin superfamily member 9 Homo sapiens 36-40 21193579-4 2011 Other members of the NRT1 family are involved subsequently in loading and unloading of nitrate to and from the xylem vessels, allowing its distribution to aerial organs or its remobilization from old leaves. Nitrates 87-94 immunoglobulin superfamily member 9 Homo sapiens 21-25 21132432-7 2011 Second, gene expression of AOX is suppressed when N is predominately available as nitrate instead of ammonium. Nitrates 82-89 acyl-CoA oxidase 1 Homo sapiens 27-30 21184738-8 2011 While nNOS inhibition at 4h was associated with a trend toward improved survival and significantly reduced contents of lung nitrite/nitrate (NO(x)) and liver malondialdehyde, the blockade of nNOS at 8h had no effect on these parameters. Nitrates 132-139 nitric oxide synthase 1, neuronal Mus musculus 6-10 21226927-20 2011 In addition, medication with nitrates reduced the risk of being CLR. Nitrates 29-37 doublecortin like kinase 3 Homo sapiens 64-67 20706193-6 2011 In Ang II + HS fed KO mice, the urinary excretion rate of nitrite/nitrate (U(NOx)V) markedly increased but 8-isoprostane excretion rate remained unchanged. Nitrates 66-73 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 3-9 21737912-6 2011 Reverse transcription-polymerase chain reaction (RT-PCR) showed that the expression levels of GmATG8i and GmATG4 increase in a starvation medium, but at a null or marginal level in a sucrose/nitrate-rich medium. Nitrates 191-198 autophagy-related protein 8i Glycine max 94-101 20540036-9 2011 Nitrate levels were negatively associated with Hcy, ADMA and LpPLA2 activity. Nitrates 0-7 phospholipase A2 group VII Homo sapiens 61-67 20967313-4 2010 Moreover, our simulation results suggest that the experimentally observed complex UO(2)(NO(3))(2) 2TBP is formed after the migration of the aforementioned complexes into the organic phase by means of a reorganization of the nitrate binding mode from mono to bidentate which removes the excess oxygen atoms bound to uranyl. Nitrates 224-231 TATA-box binding protein Homo sapiens 99-102 21397917-3 2011 Bottom nitrate concentrations (5.7-16.8 muM; avg. Nitrates 7-14 latexin Homo sapiens 40-43 22097076-1 2011 The present study aimed at developing a universal method for the localization of critical source areas (CSAs) of diffuse nitrate (NO3-) pollution in rural catchments with low data availability. Nitrates 121-128 NBL1, DAN family BMP antagonist Homo sapiens 130-133 21090606-3 2010 This study investigates the intake of perchlorate, nitrate, and iodide attributable to direct and indirect tap water consumption. Nitrates 51-58 nuclear RNA export factor 1 Homo sapiens 107-110 21045638-3 2010 Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often considered inert end products from nitric oxide generation, can be reduced back to nitric oxide and other bioactive nitrogen oxide species. Nitrates 106-113 NBL1, DAN family BMP antagonist Homo sapiens 115-118 21090606-10 2010 Using individual tap water consumption data and body weight, we estimated the median perchlorate, nitrate, and iodide dose attributable to tap water as 9.11, 11300, and 43.3 ng/kg-day, respectively, for U.S. adults. Nitrates 98-105 nuclear RNA export factor 1 Homo sapiens 139-142 21360884-7 2010 When COD/N were 6-7, it can meet the requirement for carbon source during aerobic denitrification, the removal rate of nitrate nitrogen and COD were up to 96%, 85% respectively. Nitrates 119-126 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 5-8 20662039-5 2010 Nitrate (NO3-), can be considered as an alternative electron acceptor, which can support oxidation of As(III) to As(V) by denitrifying bacteria. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 21265445-7 2010 Whole-stream nitrate uptake and denitrification in our study streams closely followed first-order uptake kinetics, indicating that NO3 uptake is limited by delivery of substrate (NO3) to the organisms involved in uptake or denitrification. Nitrates 13-20 NBL1, DAN family BMP antagonist Homo sapiens 131-134 20815776-6 2010 It is shown that palmitate caused induction of iNOS resulting in increased nitrite/nitrate concentration and slight increase in TG content. Nitrates 83-90 nitric oxide synthase 2 Rattus norvegicus 47-51 20738805-3 2010 Nitrate reductase enzyme activity is responsible for the reduction of nitrate to nitrite, and nitrate is the major form of nitrogen assimilated in plants. Nitrates 70-77 nitrate reductase [NADH] 1 Zea mays 0-17 20837581-2 2010 (2010) identified AtNRT1.8 as a membrane transporter involved in the control of long-distance transport of nitrate between roots and shoot. Nitrates 107-114 nitrate transporter 1.1 Arabidopsis thaliana 18-24 21589287-2 2010 Given that the Zn-O interactions [2.4926 (15) and 2.6673 (15) A] can be considered as weakly bonding and the nitrate ions share the same C(2) axis of the Zn(dpp)(2) fragment (dpp is 4,7-diphenyl-1,10-phenanthroline), these anions belong to the coordination sphere of Zn(2+), leading to a complex with an overall coordination number of 8 for the metal ion. Nitrates 109-116 dentin sialophosphoprotein Homo sapiens 157-160 20386496-6 2010 Negative correlations between nitrates, nitrotyrosine, and MLC2 levels were observed. Nitrates 30-38 myosin light chain 12B Homo sapiens 59-63 20880842-10 2010 We conclude that HpUre2 is involved in salt tolerance and also in nitrate assimilation gene derepression via Ca(2+) homeostasis regulation and calcineurin activation, which control the levels of Gat1. Nitrates 66-73 Gat1p Saccharomyces cerevisiae S288C 195-199 19911291-4 2010 The potential consequences, in terms of water pollution from nitrates of a BMP expressly applied to reduce P pollution are also discussed. Nitrates 61-69 bone morphogenetic protein 1 Homo sapiens 75-78 20964367-7 2010 The pattern of nitrate yield is believed to be attributable to the fact that when urea serves as the source of reduced-N, entry into the reactions that describe chlorination of ammoniacal nitrogen is through NCl3, whereas when NH3 is the source of reduced-N, entry to these reactions is through NH2Cl. Nitrates 15-22 calpain 5 Homo sapiens 208-212 20854429-7 2010 Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase. Nitrates 84-92 FAM111 trypsin like peptidase B Homo sapiens 17-21 20854429-7 2010 Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase. Nitrates 84-92 FAM111 trypsin like peptidase B Homo sapiens 162-166 20845308-3 2010 The nitrate reductase (NR) gene, which plays a central role in nitrate acquisition, was the target gene for this research. Nitrates 4-11 nitrate reductase [NADH] 1 Zea mays 23-25 20822503-2 2010 In Arabidopsis, members of the chloride channel (CLC) family located in intracellular organelles have been shown to be required for nitrate homeostasis or pH adjustment, and previous results indicated that AtCLCc is involved in nitrate accumulation. Nitrates 132-139 chloride channel C Arabidopsis thaliana 206-212 20822503-2 2010 In Arabidopsis, members of the chloride channel (CLC) family located in intracellular organelles have been shown to be required for nitrate homeostasis or pH adjustment, and previous results indicated that AtCLCc is involved in nitrate accumulation. Nitrates 228-235 chloride channel C Arabidopsis thaliana 206-212 20946657-3 2010 The level of methemoglobin in the blood is the biomarker often used in research for assessing exposure to nitrates. Nitrates 106-114 hemoglobin subunit gamma 2 Homo sapiens 13-26 20935411-3 2010 There are some methods to treat CSX including statins, b blocker, angiotensin converting enzyme inhibitors, nitrates, estrogen, and so on. Nitrates 108-116 NK2 homeobox 5 Homo sapiens 32-35 20694272-8 2010 TPA was applied to monitoring photochemical OH production by nitrate, nitrite and dissolved organic matter (DOM), and OH quenching rate constants measured for DOM were similar to results from previous studies. Nitrates 61-68 plasminogen activator, tissue type Homo sapiens 0-3 20131084-4 2010 PCNB at an initial concentration of 13 muM was transformed to PCA simultaneously with nitrate reduction but only after the nitrate concentration was at or below 20 mg N/l. Nitrates 86-93 latexin Homo sapiens 39-42 20498409-12 2010 In contrast, BALF nitrite+nitrate levels were decreased in apoA-I(-/-) mice. Nitrates 26-33 apolipoprotein A-I Mus musculus 59-65 20561257-1 2010 AtNRT2.1, a polypeptide of the Arabidopsis thaliana two-component inducible high-affinity nitrate transport system (IHATS), is located within the plasma membrane. Nitrates 90-97 nitrate transporter 2:1 Arabidopsis thaliana 0-8 20547419-5 2010 Circulation of Arabian Sea high salinity waters with nitrate deficit could also be seen from low N/P ratio with a minimum of 8.9 in spring and a maximum of 13.6 in winter. Nitrates 53-60 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 23-26 20561257-2 2010 The monomeric form of AtNRT2.1 has been reported to be the most abundant form, and was suggested to be the form that is active in nitrate transport. Nitrates 130-137 nitrate transporter 2:1 Arabidopsis thaliana 22-30 20598093-0 2010 The proline 160 in the selectivity filter of the Arabidopsis NO(3)(-)/H(+) exchanger AtCLCa is essential for nitrate accumulation in planta. Nitrates 109-116 chloride channel A Arabidopsis thaliana 85-91 20598093-3 2010 In contrast to other CLC family members, AtCLCa transports nitrate coupled to protons. Nitrates 59-66 chloride channel A Arabidopsis thaliana 41-47 20561257-9 2010 This result, together with the finding that the oligomer is absent from NRT2.1 or NAR2.1 mutants, suggests that this complex, rather than monomeric AtNRT2.1, is the form that is active in IHATS nitrate transport. Nitrates 194-201 nitrate transporter 2:1 Arabidopsis thaliana 148-156 20561257-10 2010 The molecular mass of the intact oligomer suggests that the functional unit for high-affinity nitrate influx may be a tetramer consisting of two subunits each of AtNRT2.1 and AtNAR2.1. Nitrates 94-101 nitrate transporter 2:1 Arabidopsis thaliana 162-170 20668061-0 2010 Multiple regulatory elements in the Arabidopsis NIA1 promoter act synergistically to form a nitrate enhancer. Nitrates 92-99 nitrate reductase 1 Arabidopsis thaliana 48-52 20668061-4 2010 A 1.8-kb promoter fragment from the nitrate reductase gene NIA1 was identified that acts as a nitrate enhancer when fused to a 35S minimal promoter. Nitrates 36-43 nitrate reductase 1 Arabidopsis thaliana 59-63 20668061-10 2010 These findings were validated in transgenic Arabidopsis plants and identify a cis-regulatory module containing three elements that comprise a nitrate enhancer in the NIA1 promoter. Nitrates 142-149 nitrate reductase 1 Arabidopsis thaliana 166-170 20870960-5 2010 In this study, LCI1 was placed under the control of the nitrate reductase promoter, allowing for the induction of LCI1 expression by nitrate in the absence of other CCM components. Nitrates 56-63 uncharacterized protein Chlamydomonas reinhardtii 15-19 20598093-8 2010 Our results confirm the significance of this amino acid in the conserved selectivity filter of CLC proteins and highlight the importance of the proline in AtCLCa for nitrate metabolism in Arabidopsis. Nitrates 166-173 chloride channel A Arabidopsis thaliana 155-161 20870960-5 2010 In this study, LCI1 was placed under the control of the nitrate reductase promoter, allowing for the induction of LCI1 expression by nitrate in the absence of other CCM components. Nitrates 56-63 uncharacterized protein Chlamydomonas reinhardtii 114-118 21588529-2 2010 The Co(II) atom (site symmetry 2) is six-coordinate in a distorted octahedral configuration bonded by two N and two O atoms from two (2-amino-phen-yl)methanol ligands and two O atoms from the two nitrate anions. Nitrates 196-203 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-10 20449593-4 2010 For this, we equipped a recently developed amiRNA expression vector with the NIT1 promoter, which is repressed by ammonium and activated by nitrate. Nitrates 140-147 uncharacterized protein Chlamydomonas reinhardtii 77-81 20449593-6 2010 HSF1 transcripts in transformants were already reduced ~2 h after transfer from ammonium to nitrate-containing medium. Nitrates 92-99 uncharacterized protein Chlamydomonas reinhardtii 0-4 20449593-8 2010 HSF1 levels recovered partly when transformant cells were shifted back to ammonium for 72 h. Transformants developed thermosensitivity only on nitrate and thermosensitivity correlated with strong reduction in HSF1 levels, hence supporting our earlier conclusion that HSF1 is a key regulator for thermotolerance in Chlamydomonas. Nitrates 143-150 uncharacterized protein Chlamydomonas reinhardtii 0-4 21090302-1 2010 The PBS material that in the form of insoluble biodegradable polymers pellets was investigated as the solid carbon source and the biofilm carrier for nitrate removal from wastewater. Nitrates 150-157 cholinergic receptor muscarinic 3 Homo sapiens 4-7 20608721-0 2010 Identification of organic nitrates in the NO3 radical initiated oxidation of alpha-pinene by atmospheric pressure chemical ionization mass spectrometry. Nitrates 26-34 NBL1, DAN family BMP antagonist Homo sapiens 42-45 20575535-1 2010 A novel instrument is described that quantifies total particle-phase organic nitrates in real time with a detection limit of 0.11 microg m(-3) min(-1), 45 ppt min(-1) (-ONO(2)). Nitrates 77-85 CD59 molecule (CD59 blood group) Homo sapiens 143-149 20551918-3 2010 Rats receiving co-treatment with dietary BH(4) and eNOS gene transfer (the [eNOS, +BH(4)] group) had greater eNOS expression, phospho-eNOS expression (Ser(1177)), Ca(2+)-dependent NOS activity, and nitrite + nitrate concentrations in the ischemic gastrocnemius than did rats receiving AdeNOS alone. Nitrates 208-215 nitric oxide synthase 3 Rattus norvegicus 51-55 20563339-0 2010 [NO3[symbol: see text]{(en)Pt(2,2"-bpz)}3]NO3(SO4)2: snapshot of nitrate insertion into a cationic Pt3 metallacycle or simply a packing effect? Nitrates 65-72 zinc finger protein 135 Homo sapiens 99-102 20575535-1 2010 A novel instrument is described that quantifies total particle-phase organic nitrates in real time with a detection limit of 0.11 microg m(-3) min(-1), 45 ppt min(-1) (-ONO(2)). Nitrates 77-85 CD59 molecule (CD59 blood group) Homo sapiens 159-165 20085572-9 2010 Although CNP 100 nM and 1 microM was observed to increase nitrite + nitrate (stable metabolites of NO) production in HUVEC two-fold above basal level, the soluble guanylyl cyclase inhibitor ODQ 10 microM did not significantly modify CNP-stimulated cGMP accumulation suggesting that endothelial actions of CNP may be NO-independent. Nitrates 68-75 natriuretic peptide C Homo sapiens 9-12 20682995-5 2010 Interestingly, the beta-catenin system was activated by the nitro-oxy derivative as well as by benzyl nitrate alone more potently than by the parent compound celecoxib, suggesting a possible regulatory role for NO. Nitrates 102-109 catenin beta 1 Homo sapiens 19-31 20444232-0 2010 Identification of a nitrate-responsive cis-element in the Arabidopsis NIR1 promoter defines the presence of multiple cis-regulatory elements for nitrogen response. Nitrates 20-27 nitrite reductase 1 Arabidopsis thaliana 70-74 19496011-4 2010 Ninety-seven percent of the water samples showed nitrate (NO3-) concentrations above the human affected value (13 mg l(-1) NO3-), while 15% exceeded the maximum acceptable level (50 mg l(-1) NO3-) according to WHO regulations. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 58-61 20444232-2 2010 To identify the cis-acting DNA element involved in nitrate-responsive gene expression, we analyzed the promoter of the Arabidopsis gene encoding nitrite reductase (NIR1). Nitrates 51-58 nitrite reductase 1 Arabidopsis thaliana 145-162 20587040-10 2010 PDE-5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death. Nitrates 37-44 phosphodiesterase 5A Homo sapiens 0-5 20444232-2 2010 To identify the cis-acting DNA element involved in nitrate-responsive gene expression, we analyzed the promoter of the Arabidopsis gene encoding nitrite reductase (NIR1). Nitrates 51-58 nitrite reductase 1 Arabidopsis thaliana 164-168 20444232-3 2010 A region from positions -188 to -1, relative to the translation start site, was found to contain at least one cis-element necessary for the nitrate-dependent activation of the promoter, in which the activity of nitrate transporter NRT2.1 and/or NRT2.2 plays a critical role. Nitrates 140-147 nitrate transporter 2:1 Arabidopsis thaliana 231-237 20444232-3 2010 A region from positions -188 to -1, relative to the translation start site, was found to contain at least one cis-element necessary for the nitrate-dependent activation of the promoter, in which the activity of nitrate transporter NRT2.1 and/or NRT2.2 plays a critical role. Nitrates 140-147 nitrate transporter 2:1 Arabidopsis thaliana 231-235 20444232-4 2010 To define this nitrate-responsive cis-element (NRE), we compared the sequences of several nitrite reductase gene promoters from various higher plants and identified a conserved sequence motif as the putative NRE. Nitrates 15-22 nitrite reductase 1 Arabidopsis thaliana 90-107 20444232-6 2010 Furthermore, mutations within this conserved motif in the native NIR1 promoter markedly reduced the nitrate-responsive activity of the promoter, indicating that the 43-bp sequence is an NRE that is both necessary and sufficient for nitrate-responsive transcription. Nitrates 100-107 nitrite reductase 1 Arabidopsis thaliana 65-69 20444232-6 2010 Furthermore, mutations within this conserved motif in the native NIR1 promoter markedly reduced the nitrate-responsive activity of the promoter, indicating that the 43-bp sequence is an NRE that is both necessary and sufficient for nitrate-responsive transcription. Nitrates 232-239 nitrite reductase 1 Arabidopsis thaliana 65-69 20444232-7 2010 We also show that both the native NIR1 promoter and the synthetic promoter display a similar level of sensitivity to nitrate, but respond differentially to exogenously supplied glutamine, indicating independent modulation of NIR1 expression by NRE-mediated nitrate induction and feedback repression mediated by other cis-element(s). Nitrates 117-124 nitrite reductase 1 Arabidopsis thaliana 34-38 20444232-7 2010 We also show that both the native NIR1 promoter and the synthetic promoter display a similar level of sensitivity to nitrate, but respond differentially to exogenously supplied glutamine, indicating independent modulation of NIR1 expression by NRE-mediated nitrate induction and feedback repression mediated by other cis-element(s). Nitrates 257-264 nitrite reductase 1 Arabidopsis thaliana 225-229 20669724-5 2010 The results highlighted a significant reductive microbial activity in seepage water from either denitrification or dissimilatory nitrate reduction to ammonium (DNRA), leading to nitrate (NO3(-)) consumption. Nitrates 129-136 NBL1, DAN family BMP antagonist Homo sapiens 187-190 20669724-5 2010 The results highlighted a significant reductive microbial activity in seepage water from either denitrification or dissimilatory nitrate reduction to ammonium (DNRA), leading to nitrate (NO3(-)) consumption. Nitrates 178-185 NBL1, DAN family BMP antagonist Homo sapiens 187-190 20499882-5 2010 Low concentrations of the NO donor, DETA NONOate (<200 microM), exclusively nitrate Tyr327 within the tetramerization domain promoting p53 oligomerization, nuclear accumulation, and increased DNA-binding activity without p53 Ser15 phosphorylation. Nitrates 79-86 tumor protein p53 Homo sapiens 138-141 20587040-10 2010 PDE-5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death. Nitrates 45-52 phosphodiesterase 5A Homo sapiens 0-5 20627068-3 2010 The dual transporter NRT1.1 uses both nitrate and the plant hormone auxin as substrates, enabling soil nitrate availability to regulate auxin-driven lateral root development. Nitrates 38-45 immunoglobulin superfamily member 9 Homo sapiens 21-25 20627068-3 2010 The dual transporter NRT1.1 uses both nitrate and the plant hormone auxin as substrates, enabling soil nitrate availability to regulate auxin-driven lateral root development. Nitrates 103-110 immunoglobulin superfamily member 9 Homo sapiens 21-25 20627075-0 2010 Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 37-41 20627075-2 2010 In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor. Nitrates 27-34 nitrate transporter 1.1 Arabidopsis thaliana 20-24 20627075-2 2010 In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor. Nitrates 62-69 nitrate transporter 1.1 Arabidopsis thaliana 20-24 20627075-4 2010 Herein we show that NRT1.1 not only transports nitrate but also facilitates uptake of the phytohormone auxin. Nitrates 47-54 nitrate transporter 1.1 Arabidopsis thaliana 20-24 20627075-5 2010 Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Nitrates 10-17 nitrate transporter 1.1 Arabidopsis thaliana 27-31 20627075-5 2010 Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Nitrates 10-17 nitrate transporter 1.1 Arabidopsis thaliana 108-112 20627075-5 2010 Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Nitrates 90-97 nitrate transporter 1.1 Arabidopsis thaliana 27-31 20627075-5 2010 Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport. Nitrates 90-97 nitrate transporter 1.1 Arabidopsis thaliana 108-112 20627075-7 2010 Mutation of NRT1.1 enhances both auxin accumulation in lateral roots and growth of these roots at low, but not high, nitrate concentration. Nitrates 117-124 nitrate transporter 1.1 Arabidopsis thaliana 12-16 20627075-8 2010 Thus, we propose that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. Nitrates 66-73 nitrate transporter 1.1 Arabidopsis thaliana 22-28 20211595-7 2010 This role of AOX in the mitochondrial plasticity makes logical the localization of Aox1 in a nitrate assimilation gene cluster. Nitrates 93-100 uncharacterized protein Chlamydomonas reinhardtii 83-87 19565320-6 2010 At univariate Cox regression analysis, a reduced probability of VVS occurrence after nitrates was associated with greater systolic blood pressure and body mass index values, to male gender and smoking. Nitrates 85-93 cytochrome c oxidase subunit 8A Homo sapiens 14-17 20092674-6 2010 Plasma intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated positively with plasma 3-nitrotyrosine (p=0.019) and nitrite/nitrate (p=0.019), respectively. Nitrates 151-158 vascular cell adhesion molecule 1 Homo sapiens 45-78 20394470-0 2010 Co-possession of phosphodiesterase type-5 inhibitors (PDE5-I) with nitrates. Nitrates 67-75 phosphodiesterase 5A Homo sapiens 54-58 20394470-1 2010 OBJECTIVE: Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Nitrates 106-114 phosphodiesterase 5A Homo sapiens 74-78 20394470-7 2010 When co-possessed prescriptions were defined by overlapping exposure periods, the proportion of PDE5-I patients with co-possessed nitrates ranged from 1.44% (tadalafil) to 1.72% (vardenafil) and 2.13% (sildenafil). Nitrates 130-138 phosphodiesterase 5A Homo sapiens 96-100 20394470-9 2010 The majority (54.29%) of co-possessed PDE5-I and nitrate prescriptions had the nitrate dispensed prior to the PDE5-I prescription identified in the study cohort. Nitrates 49-56 phosphodiesterase 5A Homo sapiens 110-114 20394470-9 2010 The majority (54.29%) of co-possessed PDE5-I and nitrate prescriptions had the nitrate dispensed prior to the PDE5-I prescription identified in the study cohort. Nitrates 79-86 phosphodiesterase 5A Homo sapiens 38-42 20226578-4 2010 The implementation of a sulphur emission control area (SECA) in the North Sea, as it was implemented at the end of 2007, directly results in reduced sulphur dioxide and sulphate aerosol concentrations while nitrate aerosol concentrations are slightly increased. Nitrates 207-214 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 74-77 20092674-7 2010 Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003). Nitrates 85-92 interleukin 1 beta Homo sapiens 20-37 20430631-2 2010 We report here the inhibitory capacities of some organic nitrates against two human (hCA) isozymes, hCA I and hCA II. Nitrates 57-65 HCA1 Homo sapiens 85-88 20430762-3 2010 CLC-a, a member of the CLC family of anion transporters, is critically involved in this nitrate storage in the vacuole, while other CLC family members apparently have different roles in diverse cell organelles. Nitrates 88-95 chloride channel A Arabidopsis thaliana 0-5 20430762-5 2010 CLC-b conducted strongly outwardly rectifying anionic currents that were largest in the presence of nitrate. Nitrates 100-107 chloride channel B Arabidopsis thaliana 0-5 20036660-2 2010 In Arabidopsis thaliana, AtClC-a has been recently shown to be a NO(3)(-)/H(+) antiporter critical for nitrate transport into the vacuoles. Nitrates 103-110 chloride channel A Arabidopsis thaliana 25-32 20430631-2 2010 We report here the inhibitory capacities of some organic nitrates against two human (hCA) isozymes, hCA I and hCA II. Nitrates 57-65 cytochrome P450 family 24 subfamily A member 1 Homo sapiens 100-116 20298504-4 2010 In both strains, FNR was required for normal fumarate- and nitrate-dependent respiration. Nitrates 59-66 fnr Vibrio fischeri ES114 17-20 20304912-0 2010 Point mutation of a plastidic invertase inhibits development of the photosynthetic apparatus and enhances nitrate assimilation in sugar-treated Arabidopsis seedlings. Nitrates 106-113 alkaline/neutral invertase Arabidopsis thaliana 30-39 20378150-9 2010 Nitrate reduction was not significantly inhibited by acenaphthene and 4-NP and furthermore was resistant to LAS toxicity (105 mgL(-1)). Nitrates 0-7 LLGL scribble cell polarity complex component 1 Homo sapiens 126-132 19533679-2 2010 Here, we show that training rats in an object recognition (OR) learning task rapidly increased nitrites/nitrates (NOx) content in the CA1 region of the dorsal hippocampus while posttraining intra-CA1 microinfusion of the neuronal NO synthase (nNOS) inhibitor L-NN hindered OR LTM retention without affecting memory retrieval or other behavioral variables. Nitrates 104-112 carbonic anhydrase 1 Rattus norvegicus 134-137 20442374-1 2010 Nitrate assimilation in plants and related organisms is a highly regulated and conserved pathway in which the enzyme nitrate reductase (NR) occupies a central position. Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 117-134 20501909-0 2010 The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Nitrates 16-23 nitrate transporter 1.1 Arabidopsis thaliana 36-40 20501909-0 2010 The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance. Nitrates 16-23 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 87-90 20501909-3 2010 NRT1.8 is upregulated by nitrate. Nitrates 25-32 nitrate transporter 1.1 Arabidopsis thaliana 0-4 20501909-6 2010 Electrophysiological and nitrate uptake analyses using Xenopus laevis oocytes showed that NRT1.8 mediates low-affinity nitrate uptake. Nitrates 25-32 nitrate transporter 1.1 Arabidopsis thaliana 90-94 20501909-6 2010 Electrophysiological and nitrate uptake analyses using Xenopus laevis oocytes showed that NRT1.8 mediates low-affinity nitrate uptake. Nitrates 119-126 nitrate transporter 1.1 Arabidopsis thaliana 90-94 20501909-7 2010 Functional disruption of NRT1.8 significantly increased the nitrate concentration in xylem sap. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 25-29 20501909-7 2010 Functional disruption of NRT1.8 significantly increased the nitrate concentration in xylem sap. Nitrates 60-67 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 91-94 20501909-8 2010 These data together suggest that NRT1.8 functions to remove nitrate from xylem vessels. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 33-37 20501909-9 2010 Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 15-19 20501909-9 2010 Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype. Nitrates 169-176 nitrate transporter 1.1 Arabidopsis thaliana 15-19 20501909-9 2010 Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype. Nitrates 169-176 nitrate transporter 1.1 Arabidopsis thaliana 144-148 20501909-11 2010 These data suggest that NRT1.8-regulated nitrate distribution plays an important role in Cd(2+) tolerance. Nitrates 41-48 nitrate transporter 1.1 Arabidopsis thaliana 24-28 20442374-1 2010 Nitrate assimilation in plants and related organisms is a highly regulated and conserved pathway in which the enzyme nitrate reductase (NR) occupies a central position. Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 136-138 20225831-3 2010 Two structural series have been prepared by reacting in water rare earth nitrates (Ln(III) = La, Pr, Nd, Sm, Eu, Gd, Dy, Ho) with K(3)[M(CN)(6)] (M(III) = Fe, Co) in the presence of hexamethylenetetramine (hmt). Nitrates 73-81 mitochondrially encoded cytochrome c oxidase III Homo sapiens 86-89 20448437-8 2010 In contrast, endothelial nitric oxide synthase (eNOS) was expressed in both types of EPCs, and both cell types could produce nitric oxide (NO), as judged by measuring the total amounts of nitrites and nitrates in culture media. Nitrates 201-209 nitric oxide synthase 3 Homo sapiens 13-46 19939965-0 2010 Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance. Nitrates 89-96 protein phosphatase 1, regulatory subunit 12A Mus musculus 50-55 19939965-1 2010 AIMS: A depressed cGMP-dependent protein kinase (PKG) activity is implicated in nitrate tolerance. Nitrates 80-87 protein kinase cGMP-dependent 1 Homo sapiens 49-52 19939965-2 2010 The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance. Nitrates 199-206 protein phosphatase 1, regulatory subunit 12A Mus musculus 82-117 19939965-2 2010 The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance. Nitrates 199-206 protein phosphatase 1, regulatory subunit 12A Mus musculus 119-124 19939965-2 2010 The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance. Nitrates 199-206 protein kinase cGMP-dependent 1 Homo sapiens 152-155 19939965-7 2010 Protein levels of MYPT1 (LZ+), but not of PP1Cdelta, were significantly reduced in in vitro and in vivo nitrate-tolerant arteries. Nitrates 104-111 protein phosphatase 1, regulatory subunit 12A Mus musculus 18-23 19939965-11 2010 CONCLUSION: This study demonstrates that a reduction in the protein level of MYPT1 (LZ+) is involved in nitrate tolerance. Nitrates 104-111 protein phosphatase 1, regulatory subunit 12A Mus musculus 77-82 20701008-2 2010 It is well known the toxic action of nitrate upon organisms, by formatting methemoglobin and N-nitroso compounds. Nitrates 37-44 hemoglobin subunit gamma 2 Homo sapiens 75-88 20157049-7 2010 Improvement of vascular function in this particular model of arterial hypertension by pentaerythritol tetranitrate largely depends on the induction of the antioxidant enzyme HO-1 and identifies pentaerythritol tetranitrate, in contrast to isosorbide-5 mononitrate, as an organic nitrate able to improve rather than to worsen endothelial function. Nitrates 107-114 heme oxygenase 1 Rattus norvegicus 174-178 20701008-8 2010 The maximum methemoglobin level was 60% and the minimum value of nitrate concentration in the water samples was 396 mg NO3-/L. Nitrates 65-72 NBL1, DAN family BMP antagonist Homo sapiens 119-122 20701008-9 2010 CONCLUSIONS: We established a direct correlation between the level of methemoglobin and the nitrate concentrations in water samples. Nitrates 92-99 hemoglobin subunit gamma 2 Homo sapiens 70-83 20163092-1 2010 We examined the kinetics of nitrate reduction by periplasmic nitrate reductase (Nap) by using protein film voltammetry and solution assays. Nitrates 28-35 catenin beta like 1 Homo sapiens 80-83 20307293-2 2010 Accordingly, metabolic investigations of the microbial biofilm communities of human dental plaque have focused on aerobic respiration and acid fermentation of carbohydrates, even though it is known that the oral habitat is constantly exposed to nitrate (NO3-) concentrations in the millimolar range and that dental plaque houses bacteria that can reduce this NO3- to nitrite (NO2-). Nitrates 245-252 NBL1, DAN family BMP antagonist Homo sapiens 254-257 20067832-3 2010 PCB treatment reduced inducible nitric oxide synthase (iNOS) expression as well as levels of nitrite/nitrate in both cell lines. Nitrates 101-108 pyruvate carboxylase Homo sapiens 0-3 20142497-0 2010 Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana. Nitrates 0-7 auxin signaling F-box 3 Arabidopsis thaliana 26-30 20142497-7 2010 However, only AFB3 was regulated by nitrate in roots under our experimental conditions. Nitrates 36-43 auxin signaling F-box 3 Arabidopsis thaliana 14-18 20142497-8 2010 Analysis of the expression of this miR393/AFB3 module, revealed an incoherent feed-forward mechanism that is induced by nitrate and repressed by N metabolites generated by nitrate reduction and assimilation. Nitrates 120-127 auxin signaling F-box 3 Arabidopsis thaliana 42-46 20142497-8 2010 Analysis of the expression of this miR393/AFB3 module, revealed an incoherent feed-forward mechanism that is induced by nitrate and repressed by N metabolites generated by nitrate reduction and assimilation. Nitrates 172-179 auxin signaling F-box 3 Arabidopsis thaliana 42-46 20142497-9 2010 To understand the functional role of this N-regulatory module for plant development, we analyzed the RSA response to nitrate in AFB3 insertional mutant plants and in miR393 overexpressors. Nitrates 117-124 auxin signaling F-box 3 Arabidopsis thaliana 128-132 20142497-11 2010 Interestingly, regulation of RSA by nitrate was specifically mediated by AFB3, indicating that miR393/AFB3 is a unique N-responsive module that controls root system architecture in response to external and internal N availability in Arabidopsis. Nitrates 36-43 auxin signaling F-box 3 Arabidopsis thaliana 73-77 20142497-11 2010 Interestingly, regulation of RSA by nitrate was specifically mediated by AFB3, indicating that miR393/AFB3 is a unique N-responsive module that controls root system architecture in response to external and internal N availability in Arabidopsis. Nitrates 36-43 auxin signaling F-box 3 Arabidopsis thaliana 102-106 19694900-9 2010 However, the BNP decrease was larger in the high-dose nitrate group (P < 0.0001). Nitrates 54-61 natriuretic peptide B Homo sapiens 13-16 19694900-10 2010 The larger decrease in BNP in the high-dose nitrate group was already apparent 12 h after the initiation of treatment. Nitrates 44-51 natriuretic peptide B Homo sapiens 23-26 19694900-11 2010 After 48 h BNP values decreased by an average of 29 +/- 4.9% in the high-dose nitrate strategy group compared to 15 +/- 5.4% during standard therapy. Nitrates 78-85 natriuretic peptide B Homo sapiens 11-14 20154005-5 2010 Expressed in Xenopus oocytes, AtALMT12 facilitates chloride and nitrate currents, but not those of organic solutes. Nitrates 64-71 aluminum-activated, malate transporter 12 Arabidopsis thaliana 30-38 20006999-8 2010 Computer simulations that utilized the measured kinetic values confirmed this interpretation, and revealed that the V346I iNOS has an enhanced NADPH-dependent NO dioxygenase activity that converts almost 1 NO to nitrate for every NO that the enzyme releases into solution. Nitrates 212-219 nitric oxide synthase 2 Homo sapiens 122-126 20147370-5 2010 Homologs of these genes exist in other plant species, including a family of four genes of unknown function in Arabidopsis thaliana (LSU1-4), of which two were reported as strongly induced by S-deficit and to a lesser extent by salt stress and nitrate limitation. Nitrates 243-250 response to low sulfur 1 Arabidopsis thaliana 132-138 20065149-10 2010 Together, these results suggest that mPGES-1-derived PGE(2) confers protection against DOCA-salt hypertension likely via inhibition of oxidative stress or stimulation of superoxide dismutase-3 and urinary nitrate/nitrite system. Nitrates 205-212 prostaglandin E synthase Mus musculus 37-44 20031186-3 2010 At the copper cathode, electroreduction of nitrate to ammonia was optimal near -1.4 V vs Hg/HgO. Nitrates 43-50 homogentisate 1,2-dioxygenase Homo sapiens 92-95 20142047-5 2010 It was demonstrated that xanthine oxidoreductase (XOR) and possibly other enzymes can catalyze nitrate reduction under normoxic conditions in vivo. Nitrates 95-102 xanthine dehydrogenase Mus musculus 25-48 20142047-5 2010 It was demonstrated that xanthine oxidoreductase (XOR) and possibly other enzymes can catalyze nitrate reduction under normoxic conditions in vivo. Nitrates 95-102 xanthine dehydrogenase Mus musculus 50-53 19184629-3 2010 In the present research, a survey of wells (n = 1,060) was undertaken in all 13 regions of the Kingdom of Saudi Arabia to assess the contained nitrate (NO(3)) levels. Nitrates 143-150 NBL1, DAN family BMP antagonist Homo sapiens 152-157 19184629-4 2010 The results indicated variation in nitrate levels from 1.1 to 884.0 mg/L as NO(3) throughout the Kingdom. Nitrates 35-42 NBL1, DAN family BMP antagonist Homo sapiens 76-81 19184629-6 2010 The results indicated that nitrate levels exceeded the maximum contaminant limits for drinking water (45 mg/L as NO(3)) in a number of wells (n = 213) in different regions of the Kingdom. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 113-118 20109206-1 2010 BACKGROUND: Tap water may be an important source of exposure to arsenic and nitrate. Nitrates 76-83 nuclear RNA export factor 1 Homo sapiens 12-15 19449127-2 2010 Here, we report on the regulation of a cytosolic glutamine synthetase (CsGS) from Camellia sinensis (L.) O. Kuntze during developmental stages and light/dark conditions on the utilization of nitrate and ammonia. Nitrates 191-198 glutamate-ammonia ligase Homo sapiens 49-69 19932915-3 2010 In this paper we use Disjunctive Kriging to map the probability that the Nitrates Directive limit (91/676/EEC) is exceeded for the Nitrate Vulnerable Zone of the River Tagus alluvium aquifer. Nitrates 73-81 Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1 Homo sapiens 106-109 19932915-3 2010 In this paper we use Disjunctive Kriging to map the probability that the Nitrates Directive limit (91/676/EEC) is exceeded for the Nitrate Vulnerable Zone of the River Tagus alluvium aquifer. Nitrates 73-80 Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1 Homo sapiens 106-109 20933202-5 2010 Physiological levels of reactive nitrogen species (RNS) S-glutathiolate SERCA at Cys674 to increase its activity, and the augmentation of RNS in vascular diseases irreversibly oxidizes Cys674 or nitrates tyrosine residues at Tyr296-Tyr297, which are associated with loss of function. Nitrates 195-203 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 Homo sapiens 72-77 21081219-3 2010 The formation of reactive oxygen and nitrogen species in the mitochondria and the subsequent inhibition of the nitrate-bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) appear to play a central role, at least for GTN, that is, bioactivated by ALDH-2. Nitrates 111-118 aldehyde dehydrogenase 2 family member Homo sapiens 178-184 20923091-4 2010 Regardless the type of media bed and the type of wastewater, nitrate was completely removed for nitrogen loading rates up to 1.3 g NO3-N/(m2 x day). Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 131-134 21081219-3 2010 The formation of reactive oxygen and nitrogen species in the mitochondria and the subsequent inhibition of the nitrate-bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) appear to play a central role, at least for GTN, that is, bioactivated by ALDH-2. Nitrates 111-118 aldehyde dehydrogenase 2 family member Homo sapiens 260-266 21081219-6 2010 In the past, attempts to avoid nitrate-induced side effects have focused on administration schedules that would allow a "nitrate-free interval"; in the future, the role of co-therapies with antioxidant compounds and of activation of endogeneous protective pathways such as the heme oxygenase 1 (HO-1) will need to be explored. Nitrates 31-38 heme oxygenase 1 Homo sapiens 277-293 21081219-7 2010 However, the development of new nitrates, for example, tolerance-free aminoalkyl nitrates or combination of nitrate groups with established cardiovascular drugs like ACE inhibitors or AT(1)-receptor blockers (hybrid molecules) may be of great clinical interest. Nitrates 32-40 angiotensin I converting enzyme Homo sapiens 166-169 21081219-7 2010 However, the development of new nitrates, for example, tolerance-free aminoalkyl nitrates or combination of nitrate groups with established cardiovascular drugs like ACE inhibitors or AT(1)-receptor blockers (hybrid molecules) may be of great clinical interest. Nitrates 32-39 angiotensin I converting enzyme Homo sapiens 166-169 20331429-1 2010 Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast. Nitrates 76-83 superoxide dismutase 1 Homo sapiens 225-245 20331429-1 2010 Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast. Nitrates 76-83 superoxide dismutase 1 Homo sapiens 247-250 19515062-2 2010 The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NO(x)) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD). Nitrates 104-111 endothelin 1 Homo sapiens 124-141 21182762-9 2010 For example, the over-expression of a predicted gene hub encoding a transcription factor induced early in the cascade indeed leads to the modification of the kinetic nitrate response of sentinel genes such as NIR, NIA2, and NRT1.1, and several other transcription factors. Nitrates 166-173 nitrate reductase 2 Arabidopsis thaliana 214-218 21182762-9 2010 For example, the over-expression of a predicted gene hub encoding a transcription factor induced early in the cascade indeed leads to the modification of the kinetic nitrate response of sentinel genes such as NIR, NIA2, and NRT1.1, and several other transcription factors. Nitrates 166-173 nitrate transporter 1.1 Arabidopsis thaliana 224-230 20397415-2 2010 When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria. Nitrates 5-12 NBL1, DAN family BMP antagonist Homo sapiens 269-272 20397415-2 2010 When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria. Nitrates 156-163 NBL1, DAN family BMP antagonist Homo sapiens 269-272 20397415-2 2010 When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria. Nitrates 156-163 NBL1, DAN family BMP antagonist Homo sapiens 269-272 20397415-4 2010 The results showed that nitrate reduction rate improved as H2 pressure increasing, and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3- -N/(m2 x day) without nitrite accumulation. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 195-198 20397415-4 2010 The results showed that nitrate reduction rate improved as H2 pressure increasing, and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3- -N/(m2 x day) without nitrite accumulation. Nitrates 149-156 NBL1, DAN family BMP antagonist Homo sapiens 195-198 20923099-3 2010 For areas showing predicted nitrate concentrations in percolation water above the European Union (EU) groundwater quality standard of 50 mg NO3-N/L, effective agri-environmental reduction measures need to be derived and implemented to improve groundwater and surface water quality by 2015. Nitrates 28-35 NBL1, DAN family BMP antagonist Homo sapiens 140-143 19540016-5 2009 Induction of NIA2 transcription by nitrate was not influenced by HY5 or HYH. Nitrates 35-42 nitrate reductase 2 Arabidopsis thaliana 13-17 19836459-8 2010 Recombinant MMP-9 was significantly activated by NTG and its dinitrate metabolites, indicating post-translation modification of this protein by organic nitrates. Nitrates 152-160 matrix metallopeptidase 9 Homo sapiens 12-17 20351419-5 2010 The effect of aqueous matrix on As(V) sorption by the nanocrystalline LDH was found to increase in the order of nitrate < silica < sulfate < carbonate < phosphate. Nitrates 112-119 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 32-37 19540016-0 2009 The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1. Nitrates 79-86 Basic-leucine zipper (bZIP) transcription factor family protein Arabidopsis thaliana 31-34 19540016-0 2009 The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1. Nitrates 79-86 HY5-homolog Arabidopsis thaliana 39-42 19540016-0 2009 The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1. Nitrates 79-86 nitrate reductase 2 Arabidopsis thaliana 125-129 19801492-11 2009 The maintenance of cardioprotection in female mice lacking GPx1 post-I/R may be due to an improved ascorbate redox homeostasis and enhanced nitrate-to-nitrite conversion, which would predictably be accompanied by enhanced production of cardioprotective nitric oxide. Nitrates 140-147 glutathione peroxidase 1 Mus musculus 59-63 18544592-9 2009 A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration. Nitrates 70-77 colony stimulating factor 3 Homo sapiens 106-111 20187384-8 2009 However, the areas of confined water with nitrate concentrations of 5-10 mg x L(-1), 10-15 mg x L(-1) and 15-20 mg x L(-1) were increased by 28.01%, 9.33%, and 0.48% respectively, while the areas of NO3- -N concentration (0-5 mg x L(-1)) was decreased by 37.82%. Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 199-202 19811527-10 2009 Nitrates/nitrites and TBARS, metabolites of MMPs activators, were increased in the diabetic placenta and reduced by 15dPGJ(2). Nitrates 0-8 matrix metallopeptidase 2 Rattus norvegicus 44-48 20187385-8 2009 The NO3- -delta 15N values of 4.77% per hundred (n=9) show nitrate-nitrogen of S2 mainly originates from fertilizers from October, 2007 to March, 2008 and from July to October, 2008, while NO3- -delta 15N values of 3.16% per hundred +/- 0.39% per hundred (n=5) explain that the nitrate-nitrogen derives from the mixture of soil organic nitrogen and fertilizers from April to June, 2008. Nitrates 59-66 NBL1, DAN family BMP antagonist Homo sapiens 4-7 20516270-7 2009 We also show that the reduction in plasma MMP-9 levels was associated with a change in plasma nitrites/nitrates (NOx) concentration over the entire intervention (r = -0.38, p < 0.05; week 12 vs. baseline). Nitrates 103-111 matrix metallopeptidase 9 Homo sapiens 42-47 19820122-5 2009 Mice injected with Th1 cells developed progressive albuminuria over 21 d, histologic injury including 5.5 +/- 0.9% crescent formation/segmental necrosis, elevated urinary nitrate, and increased renal NOS2, CCL2, and CCL5 mRNA. Nitrates 171-178 negative elongation factor complex member C/D, Th1l Mus musculus 19-22 19732351-5 2009 The etr1-3 and ein2-1 mutants exhibited less reductions in LR length and number than wild-type plants in response to high nitrate concentration. Nitrates 122-129 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 4-10 19524003-9 2009 Significant increases in expression of endothelial (eNOS) and inducible (iNOS) isoforms of NOS mRNA and protein occurred only at coma stages of encephalopathy accompanied by increased brain nitrite/nitrate concentrations. Nitrates 198-205 nitric oxide synthase 2 Rattus norvegicus 73-77 19732351-5 2009 The etr1-3 and ein2-1 mutants exhibited less reductions in LR length and number than wild-type plants in response to high nitrate concentration. Nitrates 122-129 NRAMP metal ion transporter family protein Arabidopsis thaliana 15-19 19732351-6 2009 Expression of nitrate transporters AtNRT1.1 and AtNRT2.1 was upregulated and downregulated in response to high nitrate concentration, respectively. Nitrates 14-21 nitrate transporter 1.1 Arabidopsis thaliana 35-43 20514237-0 2009 Nitrate responses of Arabidopsis cho1 mutants: obvious only when excess nitrate is supplied. Nitrates 0-7 AINTEGUMENTA-like 5 Arabidopsis thaliana 33-37 20514237-0 2009 Nitrate responses of Arabidopsis cho1 mutants: obvious only when excess nitrate is supplied. Nitrates 72-79 AINTEGUMENTA-like 5 Arabidopsis thaliana 33-37 20514237-1 2009 We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM). Nitrates 160-167 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 56-59 20514237-1 2009 We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM). Nitrates 160-167 AINTEGUMENTA-like 5 Arabidopsis thaliana 81-88 20514237-1 2009 We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM). Nitrates 160-167 AINTEGUMENTA-like 5 Arabidopsis thaliana 90-94 20514237-3 2009 The cho1 seedlings responded to nitrate up to 10 mM similarly to the wildtype, but the inhibitory effect of excess nitrate is less prominent in the mutants. Nitrates 32-39 AINTEGUMENTA-like 5 Arabidopsis thaliana 4-8 19732351-6 2009 Expression of nitrate transporters AtNRT1.1 and AtNRT2.1 was upregulated and downregulated in response to high nitrate concentration, respectively. Nitrates 14-21 nitrate transporter 2:1 Arabidopsis thaliana 48-56 20514237-4 2009 This phenotype is restricted to the cotyledons, and growth of the hypocotyl and roots of the cho1 mutants is inhibited by excess nitrate. Nitrates 129-136 AINTEGUMENTA-like 5 Arabidopsis thaliana 93-97 20514237-6 2009 Altered nitrate distribution and storage may explain the phenotypes of the cho1 mutants. Nitrates 8-15 AINTEGUMENTA-like 5 Arabidopsis thaliana 75-79 19732351-7 2009 A similar upregulation and downregulation of AtNRT1.1 and AtNRT2.1 was observed by ethylene synthesis precursor aminocyclopropane carboxylic acid (ACC) and AVG in low and high nitrate concentration, respectively. Nitrates 176-183 nitrate transporter 1.1 Arabidopsis thaliana 45-53 19732351-7 2009 A similar upregulation and downregulation of AtNRT1.1 and AtNRT2.1 was observed by ethylene synthesis precursor aminocyclopropane carboxylic acid (ACC) and AVG in low and high nitrate concentration, respectively. Nitrates 176-183 nitrate transporter 2:1 Arabidopsis thaliana 58-66 19785658-12 2009 AFP also increased H(2)O(2) and modulated nitrite/nitrate levels in non-stimulated keratinocytes whereas it did not affect these parameters or cytokine release from UVA-stimulated cells. Nitrates 50-57 alpha fetoprotein Homo sapiens 0-3 19885533-1 2009 Our research group previously reported a two-dimensional cationic inorganic material (BING-5, Pb(3)F(5)NO(3)) where nitrate resides in the interlamellar space and can be anion exchanged. Nitrates 116-123 D6S2723E Homo sapiens 86-92 19943390-6 2009 Nitrate (NO3-) leaching increased only from the catchment without a forest buffer. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 19544384-1 2009 Halophilic (salt loving), hydrogenotrophic (H(2) oxidizing) denitrifying bacteria were investigated for treatment of nitrate (NO3-) and perchlorate (ClO4-) contaminated groundwater and ion exchange (IX) brines. Nitrates 117-124 NBL1, DAN family BMP antagonist Homo sapiens 126-129 19845487-10 2009 The cells were then exposed to Escherichia coli endotoxin to determine if increased intracellular penetration of catalase would inhibit H(2)O(2), nitrate, and cytokine synthesis. Nitrates 146-153 catalase Homo sapiens 113-121 19681094-7 2009 Analysis of iNOS protein and the associated formation of nitrites and lipid peroxidation products was performed using immunoblotting and biochemical analysis, and revealed increases in iNOS protein, nitrate levels and oxidative stress at day 1 following ionizing irradiation. Nitrates 199-206 nitric oxide synthase 2, inducible Mus musculus 12-16 19911129-3 2009 Furthermore, ALDH2 catalyzes nitroglycerin to nitrate and 1, 2-glyceryldinitrate during therapy for angina pectoris, myocardial infarction, and heart failure. Nitrates 46-53 aldehyde dehydrogenase 2 family member Homo sapiens 13-18 19636075-0 2009 ATP binding to the C terminus of the Arabidopsis thaliana nitrate/proton antiporter, AtCLCa, regulates nitrate transport into plant vacuoles. Nitrates 58-65 chloride channel A Arabidopsis thaliana 85-91 19650765-2 2009 Also, Mb plays a role in regulating *NO (nitric oxide) homoeostasis through (i) binding *NO (Mb-NO complex); (ii) oxidation of *NO to nitrate; and (iii) formation of vasoactive S-nitroso-Mb [Rayner, B.S., Wu, B.-J., Raftery, M., Stocker, R. and Witting, P.K. Nitrates 134-141 myoglobin Rattus norvegicus 6-8 19636075-2 2009 Nitrate accumulation within the vacuole is primarily mediated by the NO(3)(-)/H(+) exchanger AtCLCa, which belongs to the chloride channel (CLC) family. Nitrates 0-7 chloride channel A Arabidopsis thaliana 93-99 19766561-3 2009 (2009) show that phosphorylation of the CHL1 nitrate transporter allows the plant root to sense and respond to different nitrate concentrations in the soil. Nitrates 45-52 cell adhesion molecule L1 like Homo sapiens 40-44 19586916-6 2009 Moreover, we show that Fdx2 (Em = -321 mV), whose expression is regulated by nitrate, is a more efficient electron donor to nitrite reductase relative to Fd. Nitrates 77-84 ferredoxin 2 Homo sapiens 23-27 19586916-6 2009 Moreover, we show that Fdx2 (Em = -321 mV), whose expression is regulated by nitrate, is a more efficient electron donor to nitrite reductase relative to Fd. Nitrates 77-84 uncharacterized protein Chlamydomonas reinhardtii 124-141 19733718-6 2009 The concentrations of plasma endothelin-1, a potent vasoconstrictor peptide produced by vascular endothelial cells, significantly decreased and plasma nitric oxide (measured as the stable end product [nitrite/nitrate]), a potent vasodilator produced by vascular endothelial cells, significantly increased after the weight-reduction exercise program. Nitrates 209-216 endothelin 1 Homo sapiens 29-41 19785274-7 2009 International emissions are an additional uncontrollable and significant contribution to total sulfate (SO4) and nitrate (NO3) concentrations at the western Class I areas. Nitrates 113-120 NBL1, DAN family BMP antagonist Homo sapiens 122-125 19563531-11 2009 CONCLUSIONS AND IMPLICATIONS: The present results demonstrate that not all high potency nitrates are bioactivated by ALDH-2 and that high potency of a given nitrate is not necessarily associated with induction of oxidative stress or nitrate tolerance. Nitrates 88-96 aldehyde dehydrogenase 2, mitochondrial Mus musculus 117-123 19563531-12 2009 Obviously, there are distinct pathways for bioactivation of organic nitrates, which for AEN may involve xanthine oxidoreductase rather than P450 enzymes. Nitrates 68-76 xanthine dehydrogenase Mus musculus 104-127 19764219-2 2009 While nitrate (NO3-) reduction is energetically favored over sulfate reduction, the influence of NO3 on the accumulation of CH3Hg+ has not been reported in the literature. Nitrates 6-13 NBL1, DAN family BMP antagonist Homo sapiens 15-18 19882863-9 2009 The content of nitrates was estimated as a difference between the total level of nitro compounds and the content of RNO2. Nitrates 15-23 NLR family pyrin domain containing 12 Homo sapiens 116-120 19809847-5 2009 Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P < 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P < 0.0001) and nitrate (P < 0.0001); and (3) enhancing the formation of GSNO (P < 0.001). Nitrates 303-310 fibrinogen beta chain Homo sapiens 78-88 19734434-0 2009 The Arabidopsis nitrate transporter NRT1.7, expressed in phloem, is responsible for source-to-sink remobilization of nitrate. Nitrates 16-23 nitrate transporter 1.1 Arabidopsis thaliana 36-40 19633234-0 2009 A genetic screen for nitrate regulatory mutants captures the nitrate transporter gene NRT1.1. Nitrates 21-28 nitrate transporter 1.1 Arabidopsis thaliana 86-92 19633234-2 2009 A mutation was identified that impaired nitrate induction, and it was localized to the nitrate regulatory gene NLP7, demonstrating the validity of this screen. Nitrates 40-47 NIN like protein 7 Arabidopsis thaliana 111-115 19633234-2 2009 A mutation was identified that impaired nitrate induction, and it was localized to the nitrate regulatory gene NLP7, demonstrating the validity of this screen. Nitrates 87-94 NIN like protein 7 Arabidopsis thaliana 111-115 19633234-5 2009 The nrg1 mutation disrupted nitrate regulation of several endogenous genes as induction of three nitrate-responsive genes (NIA1, NiR, and NRT2.1) was dramatically reduced in roots of the mutant after 2-h treatment using nitrate concentrations from 0.25 to 20 mm. Nitrates 97-104 nitrate reductase 1 Arabidopsis thaliana 123-127 19633234-5 2009 The nrg1 mutation disrupted nitrate regulation of several endogenous genes as induction of three nitrate-responsive genes (NIA1, NiR, and NRT2.1) was dramatically reduced in roots of the mutant after 2-h treatment using nitrate concentrations from 0.25 to 20 mm. Nitrates 97-104 nitrate reductase 1 Arabidopsis thaliana 123-127 19633234-7 2009 The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation. Nitrates 12-19 nitrate transporter 1.1 Arabidopsis thaliana 41-47 19633234-7 2009 The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation. Nitrates 12-19 nitrate transporter 1.1 Arabidopsis thaliana 66-72 19633234-7 2009 The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation. Nitrates 103-110 nitrate transporter 1.1 Arabidopsis thaliana 41-47 19633234-10 2009 These results strongly support the model that NRT1.1 acts as a nitrate regulator or sensor in Arabidopsis. Nitrates 63-70 nitrate transporter 1.1 Arabidopsis thaliana 46-52 19734434-2 2009 This study of the Arabidopsis thaliana nitrate transporter NRT1.7 provides new insights into nitrate remobilization. Nitrates 39-46 nitrate transporter 1.1 Arabidopsis thaliana 59-63 19734434-4 2009 In nrt1.7 mutants, more nitrate was present in the older leaves, less (15)NO(3)(-) spotted on old leaves was remobilized into N-demanding tissues, and less nitrate was detected in the phloem exudates of old leaves. Nitrates 24-31 nitrate transporter 1.1 Arabidopsis thaliana 3-7 19734434-4 2009 In nrt1.7 mutants, more nitrate was present in the older leaves, less (15)NO(3)(-) spotted on old leaves was remobilized into N-demanding tissues, and less nitrate was detected in the phloem exudates of old leaves. Nitrates 156-163 nitrate transporter 1.1 Arabidopsis thaliana 3-7 19734434-5 2009 These data indicate that NRT1.7 is responsible for phloem loading of nitrate in the source leaf to allow nitrate transport out of older leaves and into younger leaves. Nitrates 69-76 nitrate transporter 1.1 Arabidopsis thaliana 25-29 19734434-5 2009 These data indicate that NRT1.7 is responsible for phloem loading of nitrate in the source leaf to allow nitrate transport out of older leaves and into younger leaves. Nitrates 105-112 nitrate transporter 1.1 Arabidopsis thaliana 25-29 19698183-10 2009 Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively. Nitrates 108-115 linoleate 13S-lipoxygenase10 Zea mays 33-48 19698183-10 2009 Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively. Nitrates 108-115 MLO-like protein 4 Zea mays 313-344 19698183-10 2009 Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively. Nitrates 108-115 MLO-like protein 4 Zea mays 346-353 18830972-8 2009 We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS). Nitrates 31-38 nitric oxide synthase 2 Homo sapiens 92-123 18830972-8 2009 We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS). Nitrates 31-38 nitric oxide synthase 2 Homo sapiens 125-129 18830972-8 2009 We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS). Nitrates 31-38 nitric oxide synthase 3 Homo sapiens 136-169 19376780-1 2009 BACKGROUND AND AIMS: Nitric oxide (NO) has been demonstrated to stimulate the activity of nitrate reductase (NR) in plant roots supplied with a low level of nitrate, and to affect proteins differently, depending on the ratio of NO to the level of protein. Nitrates 90-97 nitrate reductase [NADH] Solanum lycopersicum 109-111 19577274-2 2009 Total nitrogen removal efficiencies were 73-80% and 70-77% for the NMBR and UMBR, respectively, with 1-1.7 mgL(-1) lower effluent nitrates in the NMBR. Nitrates 130-138 LLGL scribble cell polarity complex component 1 Homo sapiens 107-113 19376780-8 2009 Nevertheless, a low rate of NO gas increased while cPTIO decreased the NR activities of the enzyme extracts from the roots at both nitrate levels. Nitrates 131-138 nitrate reductase [NADH] Solanum lycopersicum 71-73 19376780-9 2009 Increasing the rate of NO gas further increased NR activity in the enzyme extracts of the roots fed with 0.5 mM nitrate but decreased it when 5 mM nitrate was supplied. Nitrates 112-119 nitrate reductase [NADH] Solanum lycopersicum 48-50 19376780-10 2009 Interestingly, the stimulative effect of NO gas on NR activity could be reversed by NO removal through N(2) flushing in the enzyme extracts from the roots fed with 0.5 mM nitrate but not from those with 5 mM nitrate. Nitrates 171-178 nitrate reductase [NADH] Solanum lycopersicum 51-53 19376780-10 2009 Interestingly, the stimulative effect of NO gas on NR activity could be reversed by NO removal through N(2) flushing in the enzyme extracts from the roots fed with 0.5 mM nitrate but not from those with 5 mM nitrate. Nitrates 208-215 nitrate reductase [NADH] Solanum lycopersicum 51-53 19376780-11 2009 CONCLUSIONS: The effects of NO on NR activity in tomato roots depend on levels of nitrate supply, and probably result from direct interactions between NO and NR protein. Nitrates 82-89 nitrate reductase [NADH] Solanum lycopersicum 34-36 19346443-6 2009 Mechanistic studies in rats identified oxidative stress, ALDH-2 inactivation, and vascular dysfunction as common features in acute and chronic nitrate tolerance. Nitrates 143-150 aldehyde dehydrogenase 2 family member Rattus norvegicus 57-63 19376780-11 2009 CONCLUSIONS: The effects of NO on NR activity in tomato roots depend on levels of nitrate supply, and probably result from direct interactions between NO and NR protein. Nitrates 82-89 nitrate reductase [NADH] Solanum lycopersicum 158-160 19662837-1 2009 A dual isotope method of measuring both the delta 15N and delta 18O in NO3- was used to discriminate the origin of nitrate and its denitrification in groundwater in Shijiazhuang. Nitrates 115-122 NBL1, DAN family BMP antagonist Homo sapiens 71-74 19346117-4 2009 The mechanisms involved are related to: i) the reduced sensitivity to insulin and other substances acting via intracellular cyclic nucleotides, such as nitrates and prostacyclin; ii) the altered intracellular ionic milieu with elevated cytosolic Ca(2+); and iii) the increased oxidative stress, which elicits isoprostane production from arachidonic acid. Nitrates 152-160 insulin Homo sapiens 70-77 20005475-3 2009 In addition, chronic nitrate treatment results in ALDH2 inhibition and contributes to nitrate tolerance. Nitrates 21-28 aldehyde dehydrogenase 2 family member Homo sapiens 50-55 19042082-4 2009 LDH samples containing nitrate ions with parallel (LDH5) and perpendicular (LDH3) orientations exhibited different 2,4-D adsorption characteristics under competition with co-existing anions for surface binding sites. Nitrates 23-30 lactate dehydrogenase C Homo sapiens 0-3 19042082-4 2009 LDH samples containing nitrate ions with parallel (LDH5) and perpendicular (LDH3) orientations exhibited different 2,4-D adsorption characteristics under competition with co-existing anions for surface binding sites. Nitrates 23-30 lactate dehydrogenase C Homo sapiens 76-80 19042082-6 2009 On the contrary, the interlayer nitrate in LDH3 is readily exchanged by 2,4-D. Nitrates 32-39 lactate dehydrogenase C Homo sapiens 43-47 19662837-3 2009 The results show that the ratio of delta 15N/delta 18O in NO3- is close to 2:1, indicating that some denitrification is occurring in this area; The value of delta 15N and delta 18O in NO3- after denitrification are 4.6 per thousand-13.9 per thousand and 1.9 per thousand-7.8 per thousand respectively, which indicates that the main source of nitrate in groundwater are local fertilizer and Animal Waste/Septic Systems. Nitrates 342-349 NBL1, DAN family BMP antagonist Homo sapiens 58-61 19662837-3 2009 The results show that the ratio of delta 15N/delta 18O in NO3- is close to 2:1, indicating that some denitrification is occurring in this area; The value of delta 15N and delta 18O in NO3- after denitrification are 4.6 per thousand-13.9 per thousand and 1.9 per thousand-7.8 per thousand respectively, which indicates that the main source of nitrate in groundwater are local fertilizer and Animal Waste/Septic Systems. Nitrates 342-349 NBL1, DAN family BMP antagonist Homo sapiens 184-187 19500399-2 2009 Herein, a systems biology approach was developed to identify the components and role of cross-talk between nitrate and hormone signals, likely to be involved in the conditional response of NO3- signaling. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 189-192 19346351-9 2009 Besides a menaquinone source, isogenic mutants revealed that cydA and ndh1 are required for the aerobic-respiration-like response and narG for nitrate reduction. Nitrates 143-150 NAD(P)/FAD-dependent oxidoreductase Lactobacillus plantarum WCFS1 70-74 19346351-10 2009 The ndh1 mutant was still able to reduce nitrate. Nitrates 41-48 NAD(P)/FAD-dependent oxidoreductase Lactobacillus plantarum WCFS1 4-8 19493694-1 2009 Deficiency of mineral nutrients such as nitrate, phosphate, potassium and sulphate strongly affects the type and amount of metabolites produced by crops with knock-on effects on nutritional quality of the crop, its processing properties and disease resistance. Nitrates 40-47 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 147-151 19460002-8 2009 RESULTS: Application of LPS to the pulp increased NOS activity and nitrate production (P < 0.001), generated by iNOS over-activity and expression. Nitrates 67-74 nitric oxide synthase 2 Rattus norvegicus 115-119 19223666-2 2009 In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased protein [(35)S]cysteine incorporation, significant S-glutathionylation of multiple proteins, and decreased metabolic activity of several SH-sensitive enzymes, including creatine kinase, xanthine oxidoreductase, and glutaredoxin (GRX). Nitrates 32-39 glutaredoxin-1 Sus scrofa 341-353 19534114-6 2009 The peak intensities of nitrate during the nighttime and high concentrations of O3 and NO2 strongly suggest that the heterogeneous reactions of N2O5 and NO3 onthe aerosol surface dominated the particulate nitrate formation on polluted days. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 153-156 19534114-6 2009 The peak intensities of nitrate during the nighttime and high concentrations of O3 and NO2 strongly suggest that the heterogeneous reactions of N2O5 and NO3 onthe aerosol surface dominated the particulate nitrate formation on polluted days. Nitrates 205-212 NBL1, DAN family BMP antagonist Homo sapiens 153-156 19201616-1 2009 Anionic group II metal nitrate clusters of the formula [M(2)(NO(3))(5)](-), where M(2) = Mg(2), MgCa, Ca(2), and Sr(2), are investigated by infrared multiple photon dissociation (IRMPD) spectroscopy to obtain vibrational spectra in the mid-IR region. Nitrates 23-30 attractin Homo sapiens 96-100 19223666-2 2009 In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased protein [(35)S]cysteine incorporation, significant S-glutathionylation of multiple proteins, and decreased metabolic activity of several SH-sensitive enzymes, including creatine kinase, xanthine oxidoreductase, and glutaredoxin (GRX). Nitrates 32-39 glutaredoxin-1 Sus scrofa 355-358 19261613-12 2009 When inserted into the model Torpedo chloride channel ClC-0, the equivalent mutation increased nitrate relative to chloride conductance. Nitrates 95-102 Charcot-Leyden crystal galectin Homo sapiens 54-57 19261613-0 2009 Residues important for nitrate/proton coupling in plant and mammalian CLC transporters. Nitrates 23-30 Charcot-Leyden crystal galectin Homo sapiens 70-73 19325986-10 2009 STM shows that the morphology of the particle system is largely conserved during NO(2) exposure at 300 K. The reaction is limited to the formation of surface nitrites and nitrates, which are characterized by low thermal stability and completely decompose below 500 K. As no further sintering occurs before decomposition, NO(2) uptake and release is a fully reversible process. Nitrates 171-179 sulfotransferase family 1A member 3 Homo sapiens 0-3 19326931-4 2009 In the 1:3 nitrate complex, the one independent silver atom major component (0.78(1)) is closely trigonal planar AgS3 (Ag-S 2.518(2)-2.592(1) A, Sigma(S-Ag-S) 359.7(0) degrees); there are minor nearby components (0.11(1)) which may be regarded as four-coordinate, forming a putative one-dimensional polymer. Nitrates 11-18 G protein signaling modulator 1 Homo sapiens 113-117 19254277-13 2009 CONCLUSIONS AND IMPLICATIONS: These results indicate that nitrate tolerance is associated with ALDH2 inactivation, whereas ascorbate deficiency possibly results in down-regulation of ALDH2 expression. Nitrates 58-65 aldehyde dehydrogenase, mitochondrial Cavia porcellus 95-100 19147491-4 2009 Stable expression of small hairpin RNA targeting cytoglobin in fibroblasts resulted in decreased NO consumption and intracellular nitrate production. Nitrates 130-137 cytoglobin Homo sapiens 49-59 18716872-4 2009 Furthermore, NAC plus 5-ASA reduced nitrate generation, an expression of inducible nitric oxide synthase (iNOS) activity, to basal levels and these results were significantly lower than those observed with either NAC or 5-ASA alone. Nitrates 36-43 nitric oxide synthase 2 Rattus norvegicus 73-104 18716872-4 2009 Furthermore, NAC plus 5-ASA reduced nitrate generation, an expression of inducible nitric oxide synthase (iNOS) activity, to basal levels and these results were significantly lower than those observed with either NAC or 5-ASA alone. Nitrates 36-43 nitric oxide synthase 2 Rattus norvegicus 106-110 18379890-12 2009 Diurnal variation of Sulfur-dioxide and Nitrogen dioxide were found to have inverse relationship with visibility during fog which may be due to formation of secondary pollutants such as sulfate and to a lesser extent nitrates. Nitrates 217-225 zinc finger protein, FOG family member 1 Homo sapiens 120-123 23572923-0 2009 Genomewide bioinformatic analysis negates any specific role for Dof, GATA and Ag/cTCA motifs in nitrate responsive gene expression in Arabidopsis. Nitrates 96-103 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 69-73 19054349-3 2009 Transgenic seedlings constitutively over-expressing STP13 (STP13OX) had increased rates of glucose uptake, higher endogenous sucrose levels and accumulated more total C and biomass per plant when grown on soil-less media supplemented with 55 mM glucose and sufficient N (9 mM nitrate). Nitrates 276-283 Major facilitator superfamily protein Arabidopsis thaliana 52-57 18834868-0 2009 Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment. Nitrates 71-78 aldehyde dehydrogenase 2 family member Homo sapiens 38-44 19378654-4 2009 The highest denitrification rate of 0.203kg/(m3 x d) was achieved when flow rate and nitrate concentration were 153 L/d and 25.3 mgN/L, respectively. Nitrates 85-92 helt bHLH transcription factor Homo sapiens 129-132 19054349-3 2009 Transgenic seedlings constitutively over-expressing STP13 (STP13OX) had increased rates of glucose uptake, higher endogenous sucrose levels and accumulated more total C and biomass per plant when grown on soil-less media supplemented with 55 mM glucose and sufficient N (9 mM nitrate). Nitrates 276-283 Major facilitator superfamily protein Arabidopsis thaliana 59-66 19054349-5 2009 In addition, STP13OX seedlings were larger and had higher biomass than Col-0 seedlings when grown under a limiting N condition (3 mM nitrate). Nitrates 133-140 Major facilitator superfamily protein Arabidopsis thaliana 13-20 18996902-6 2009 Compared with wild-type, bronchoalveolar lavage fluid (BALF) levels of nitrite plus nitrate, GM-CSF, and MCP-1, but not TNF-alpha and IFN-gamma, were higher in SP-D-deficient mice before and after HSCT. Nitrates 84-91 surfactant associated protein D Mus musculus 160-164 19060147-10 2009 The results suggest that the Fnr and Crp proteins may act synergistically to enhance NapABC synthesis during growth with poor carbon sources to help obtain energy from low levels of nitrate. Nitrates 182-189 catabolite gene activator protein Escherichia coli 37-40 18826430-3 2009 Although the Arabidopsis ANR1 transcription factor appears to control stimulation of lateral root elongation in response to nitrate, no regulators of nitrate assimilation have so far been identified in higher plants. Nitrates 124-131 AGAMOUS-like 44 Arabidopsis thaliana 25-29 18618322-5 2009 Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc. Nitrates 137-144 carbonic anhydrase 1 Homo sapiens 42-47 18618322-5 2009 Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc. Nitrates 137-144 HCA1 Homo sapiens 42-45 19008412-5 2009 In support of the beneficial effects of pcDNA3.1-eNOS treatment being because of enhanced eNOS expression and activity, increased eNOS protein levels were documented in aorta, liver, kidney, and heart of fructose-treated rats injected with pcDNA3.1-eNOS, and corresponding elevations in nitrite/nitrate and cGMP concentrations were observed in urine. Nitrates 295-302 nitric oxide synthase 3 Rattus norvegicus 49-53 19074630-0 2009 The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy. Nitrates 74-81 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 45-53 19074630-5 2009 Profiling experiments indicated that the expression of the ABA catabolic gene CYP707A2 was regulated by exogenous nitrate. Nitrates 114-121 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 78-86 19074630-7 2009 In contrast, both endogenous and exogenous nitrate reduced ABA levels of the wild-type and cyp707a1-1 mutant seeds. Nitrates 43-50 cytochrome P450, family 707, subfamily A, polypeptide 1 Arabidopsis thaliana 91-99 19074630-8 2009 The CYP707A2 mRNA levels in developing siliques were positively correlated with different nitrate doses applied to the mother plants. Nitrates 90-97 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 4-12 19074630-9 2009 This was consistent with a role of the CYP707A2 gene in controlling seed ABA levels in response to endogenous nitrate. Nitrates 110-117 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 39-47 19074630-10 2009 The cyp707a2-1 mutant was less sensitive to exogenous nitrate for breaking seed dormancy. Nitrates 54-61 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 4-12 19074630-11 2009 Altogether, our data underline the central role of the CYP707A2 gene in the nitrate-mediated control of ABA levels during seed development and germination. Nitrates 76-83 cytochrome P450, family 707, subfamily A, polypeptide 2 Arabidopsis thaliana 55-63 19109301-0 2009 CHOTTO1, a double AP2 domain protein of Arabidopsis thaliana, regulates germination and seedling growth under excess supply of glucose and nitrate. Nitrates 139-146 AINTEGUMENTA-like 5 Arabidopsis thaliana 0-7 19109301-11 2009 In addition, growth of cho1 mutant seedlings was partially resistant to excess nitrate (50 mM), as evident from their expanded green cotyledons. Nitrates 79-86 AINTEGUMENTA-like 5 Arabidopsis thaliana 23-27 19109301-13 2009 This nitrate response was specific to the cho1 mutants and was not observed in the abi4 mutants. Nitrates 5-12 AINTEGUMENTA-like 5 Arabidopsis thaliana 42-46 18826430-5 2009 Recently, the algal homologue NIT2 was found to regulate nitrate assimilation. Nitrates 57-64 nitrilase 2 Arabidopsis thaliana 30-34 18826430-7 2009 We show that nlp7 mutants are impaired in transduction of the nitrate signal, and that the NLP7 expression pattern is consistent with a function of NLP7 in the sensing of nitrogen. Nitrates 62-69 NIN like protein 7 Arabidopsis thaliana 13-17 18826430-9 2009 We propose NLP7 as an important element of the nitrate signal transduction pathway and as a new regulatory protein specific for nitrogen assimilation in non-nodulating plants. Nitrates 47-54 NIN like protein 7 Arabidopsis thaliana 11-15 18791203-2 2009 Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction. Nitrates 275-283 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 14-33 19164562-2 2009 Infection of Rag2(-/-) mice with Helicobacter hepaticus led to accumulation of macrophages and neutrophils in the colon, a process temporally related to up-regulation of tissue inducible nitric oxide synthase (iNOS) expression at the site of infection and increased nitric oxide (NO) production, as evidenced by urinary excretion of nitrate. Nitrates 333-340 recombination activating gene 2 Mus musculus 13-17 19936118-0 2009 Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients? Nitrates 56-63 insulin Homo sapiens 33-40 18791203-2 2009 Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction. Nitrates 275-283 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 35-39 18791203-8 2009 CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation. Nitrates 152-160 interferon gamma Mus musculus 18-27 18791203-8 2009 CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation. Nitrates 152-160 nitric oxide synthase 2, inducible Mus musculus 68-72 18791203-2 2009 Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction. Nitrates 275-283 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Mus musculus 148-153 18791203-8 2009 CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation. Nitrates 152-160 protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform Mus musculus 182-187 18791203-2 2009 Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction. Nitrates 275-283 protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus 148-152 19001185-13 2009 However, in mice lacking iNOS, maximum and minimum dP/dt, as well as an indicator of isovolumic contraction, markedly increased in response to isoproterenol, associated with decreased cardiac 4-hydroxy-2-nonenal expression and urinary nitrate/nitrite. Nitrates 235-242 nitric oxide synthase 2, inducible Mus musculus 25-29 19089335-5 2009 To overcome these obstacles of nitrate therapy, direct NO- and haem-independent sGC activators have been developed, such as BAY 58-2667 (cinaciguat) and HMR1766 (ataciguat), showing unique biochemical and pharmacological properties. Nitrates 31-38 sarcoglycan beta Homo sapiens 80-83 19307691-6 2009 Recent studies have revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role in the development of nitrate and cross-tolerance. Nitrates 131-138 aldehyde dehydrogenase 2 family member Homo sapiens 192-198 19330637-2 2009 Lead, cadmium, nickel, chromium, and nitrate (NO3-) concentrations in greenhouse cucumber (Cucumis sativa L.) and bell pepper (Capsicum annuum L.) and their dietary intakes were determined. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 46-49 19307691-7 2009 The present review focus first on the role of oxidative stress and second on the role of ALDH-2 in organic nitrate bioactivation leading to the development of tolerance and cross-tolerance (endothelial dysfunction) in response to nitroglycerin treatment. Nitrates 107-114 aldehyde dehydrogenase 2 family member Homo sapiens 89-95 19307691-8 2009 Recently, the role of mitochondrial oxidative stress in the development of nitrate tolerance was demonstrated in a mouse model with a heterozygous deletion of manganese superoxide dismutase (MnSOD(+/-)), which is the mitochondrial isoform of this enzyme. Nitrates 75-82 superoxide dismutase 2, mitochondrial Mus musculus 159-189 19307691-8 2009 Recently, the role of mitochondrial oxidative stress in the development of nitrate tolerance was demonstrated in a mouse model with a heterozygous deletion of manganese superoxide dismutase (MnSOD(+/-)), which is the mitochondrial isoform of this enzyme. Nitrates 75-82 superoxide dismutase 2, mitochondrial Mus musculus 191-196 18798873-0 2009 AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response. Nitrates 91-98 Cbl proto-oncogene Homo sapiens 11-14 18798873-0 2009 AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response. Nitrates 91-98 CBL-interacting protein kinase 8 Arabidopsis thaliana 0-7 18798873-4 2009 In this study, a calcineurin B-like (CBL) -interacting protein kinase (CIPK) gene, CIPK8, was found to be involved in early nitrate signaling. Nitrates 124-131 Cbl proto-oncogene Homo sapiens 37-40 18798873-4 2009 In this study, a calcineurin B-like (CBL) -interacting protein kinase (CIPK) gene, CIPK8, was found to be involved in early nitrate signaling. Nitrates 124-131 CBL-interacting protein kinase 8 Arabidopsis thaliana 83-88 18798873-5 2009 CIPK8 expression was rapidly induced by nitrate. Nitrates 40-47 CBL-interacting protein kinase 8 Arabidopsis thaliana 0-5 18798873-6 2009 Analysis of two independent knockout mutants and a complemented line showed that CIPK8 positively regulates the nitrate-induced expression of primary nitrate response genes, including nitrate transporter genes and genes required for assimilation. Nitrates 112-119 CBL-interacting protein kinase 8 Arabidopsis thaliana 81-86 18798873-6 2009 Analysis of two independent knockout mutants and a complemented line showed that CIPK8 positively regulates the nitrate-induced expression of primary nitrate response genes, including nitrate transporter genes and genes required for assimilation. Nitrates 150-157 CBL-interacting protein kinase 8 Arabidopsis thaliana 81-86 18798873-8 2009 As cipk8 mutants were defective mainly in the low-affinity response, the high-affinity and low-affinity nitrate signaling systems are proposed to be genetically distinct, with CIPK8 involved in the low-affinity system. Nitrates 104-111 CBL-interacting protein kinase 8 Arabidopsis thaliana 3-8 18798873-9 2009 In addition, CIPK8 was found to be involved in long-term nitrate-modulated primary root growth and nitrate-modulated expression of a vacuolar malate transporter. Nitrates 57-64 CBL-interacting protein kinase 8 Arabidopsis thaliana 13-18 18798873-9 2009 In addition, CIPK8 was found to be involved in long-term nitrate-modulated primary root growth and nitrate-modulated expression of a vacuolar malate transporter. Nitrates 99-106 CBL-interacting protein kinase 8 Arabidopsis thaliana 13-18 18798873-10 2009 Taken together, our results indicate that CBL-CIPK networks are responsible not only for stress responses and potassium shortage, but also for nitrate sensing. Nitrates 143-150 Cbl proto-oncogene Homo sapiens 42-45 19053540-4 2008 In particular, the quantum yield (phi) of nitrite formation was measured and found to significantly decrease at high concentrations of nitrate for Ca(NO(3))(2). Nitrates 135-142 glucose-6-phosphate isomerase Homo sapiens 34-37 19074184-0 2009 Nod factor/nitrate-induced CLE genes that drive HAR1-mediated systemic regulation of nodulation. Nitrates 11-18 CM0216.560.nc Lotus japonicus 48-52 19074184-8 2009 Based on these findings, we propose a simple model for AUT and nitrate inhibition of nodulation mediated by LjCLE-RS1, -RS2 peptides and the HAR1 receptor-like kinase. Nitrates 63-70 CM0216.560.nc Lotus japonicus 141-145 19053540-5 2008 In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4). Nitrates 100-107 glucose-6-phosphate isomerase Homo sapiens 15-18 19053540-5 2008 In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4). Nitrates 100-107 glucose-6-phosphate isomerase Homo sapiens 247-250 19053540-5 2008 In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4). Nitrates 234-241 glucose-6-phosphate isomerase Homo sapiens 15-18 19053540-5 2008 In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4). Nitrates 234-241 glucose-6-phosphate isomerase Homo sapiens 247-250 19759441-1 2009 During ultraviolet light (UV) disinfection, nitrate (NO3-) present in raw water may transform to nitrite (NO2-) that can cause serious human diseases. Nitrates 44-51 NBL1, DAN family BMP antagonist Homo sapiens 53-56 18993072-2 2008 The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition with a series simple, inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate, and some of its isosteric species. Nitrates 324-331 carbonate dehydratase NCE103 Saccharomyces cerevisiae S288C 27-33 19759443-2 2009 Without catalysts and any additional buffer, the MFC produced electricity continuously and the power density reached 1.3 W/m3 at a loading rate of 1.6 kg COD/m3 d. Simultaneously, the COD and the nitrate removal rate were 1.4 kg COD/m3 d and 67 g NO3-N/m3 d, respectively. Nitrates 196-203 NBL1, DAN family BMP antagonist Homo sapiens 247-250 19759443-5 2009 At a high recirculation rate of 10 ml/min, the power density and the nitrate removal rate greatly increased to 34 W/m3 and 294 g NO3--N/m3 d, respectively. Nitrates 69-76 NBL1, DAN family BMP antagonist Homo sapiens 129-132 18977227-2 2008 Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A. Nitrates 162-169 hemoglobin subunit beta Homo sapiens 68-71 19075471-5 2008 Calibration graphs with linearity in the range of 0.7 - 40 muM were obtained for both nitrite and nitrate. Nitrates 98-105 latexin Homo sapiens 59-62 18653264-1 2008 Nitrate (NO3-) is often observed in surface waters draining terrestrial ecosystems that remain strongly nitrogen (N) limited. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 19189756-7 2008 Nitrate (NO3-) existed in both the PM2.5 and PM10-2.5. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 19050168-0 2008 Characterization of the Arabidopsis nitrate transporter NRT1.6 reveals a role of nitrate in early embryo development. Nitrates 36-43 nitrate transporter 1.1 Arabidopsis thaliana 56-60 19050168-1 2008 This study of the Arabidopsis thaliana nitrate transporter NRT1.6 indicated that nitrate is important for early embryo development. Nitrates 39-46 nitrate transporter 1.1 Arabidopsis thaliana 59-63 19050168-3 2008 RT-PCR, in situ hybridization, and beta-glucuronidase reporter gene analysis showed that expression of NRT1.6 is only detectable in reproductive tissue (the vascular tissue of the silique and funiculus) and that expression increases immediately after pollination, suggesting that NRT1.6 is involved in delivering nitrate from maternal tissue to the developing embryo. Nitrates 313-320 nitrate transporter 1.6 Arabidopsis thaliana 103-109 19050168-3 2008 RT-PCR, in situ hybridization, and beta-glucuronidase reporter gene analysis showed that expression of NRT1.6 is only detectable in reproductive tissue (the vascular tissue of the silique and funiculus) and that expression increases immediately after pollination, suggesting that NRT1.6 is involved in delivering nitrate from maternal tissue to the developing embryo. Nitrates 313-320 nitrate transporter 1.1 Arabidopsis thaliana 103-107 19050168-4 2008 In nrt1.6 mutants, the amount of nitrate accumulated in mature seeds was reduced and the seed abortion rate increased. Nitrates 33-40 nitrate transporter 1.1 Arabidopsis thaliana 3-7 19050168-6 2008 The phenotype of the nrt1.6 mutants revealed a novel role of nitrate in early embryo development. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 21-25 18786921-1 2008 Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance. Nitrates 101-108 aldehyde dehydrogenase 2 family member Homo sapiens 38-43 18786921-1 2008 Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance. Nitrates 101-108 aldehyde dehydrogenase 2 family member Homo sapiens 140-145 18786921-13 2008 These observations are consistent with a significant role for irreversible inactivation of ALDH2 in the development of nitrate tolerance. Nitrates 119-126 aldehyde dehydrogenase 2 family member Homo sapiens 91-96 18824664-6 2008 The cGMP agonists 8-bromo-cGMP and C-type natriuretic peptide also stimulated DDAH-2 gene and protein expression levels and DDAH activity and increased the amount of nitrite/nitrate released into the culture supernatants. Nitrates 174-181 natriuretic peptide C Rattus norvegicus 35-61 18713738-6 2008 We found that, under nitrogen limitation, Ynt1 phosphorylation is essential for rapid induction of nitrate assimilation genes. Nitrates 99-106 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 42-46 18462937-3 2008 The use of an inoculum previously acclimated to high nitrate concentrations led to complete denitrification in 6h (denitrification rate: 22.8mg NO3- -N/gVSSh), using methanol as carbon source for a COD/N ratio of 4 and for a content of calcium in the wastewater of 150mg/L. Nitrates 53-60 NBL1, DAN family BMP antagonist Homo sapiens 144-147 18074235-1 2008 We made an inventory of nitrate (NO3-N) enrichment in surface and groundwater systems in the Hooghly district of India owing to intensive farming with high fertilizer doses as a function of quantity of fertilizers use, soil characteristics, types of crop grown, depth of groundwater sampling and also N-load in soil profiles. Nitrates 24-31 NBL1, DAN family BMP antagonist Homo sapiens 33-36 19092986-12 2008 Contents of LTC(4) and nitrite/nitrate increased (p<0.01) after the low dose of TNF. Nitrates 31-38 tumor necrosis factor Bos taurus 83-86 18983076-1 2008 Nitrate (NO3) profiles in semiarid unsaturated zones archive land use change (LUC) impacts on nitrogen (N) cycling with implications for agricultural N management and groundwater quality. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 18201926-3 2008 Compared with other C atoms, the chemical shifts of both C-1 and C-5 atoms in these two types of glycosides decrease relatively rapidly as molality of calcium nitrate increases, indicating that the nitrate ion attractions for these glycosides cause a relatively strong enhancing shielding effect of C-1 and C-5 atoms. Nitrates 159-166 heterogeneous nuclear ribonucleoprotein C Homo sapiens 57-68 18563586-1 2008 CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 0-4 18701635-8 2008 Further analysis revealed that reduction of CBS activity during reperfusion was accompanied by an elevation of NO metabolites (nitrate and nitrite) in the kidney tissue. Nitrates 127-134 cystathionine beta synthase Rattus norvegicus 44-47 18946854-3 2008 Recent research has demonstrated that highly reactive nitrates, such as nitroglycerin (or glyceryl trinitrate) and pentaerthrityl tetranitrate (PETN) are bioactivated by aldehyde dehydrogenase 2 (ALDH-2), an enzyme located in mitochondria. Nitrates 54-62 aldehyde dehydrogenase 2 family member Homo sapiens 170-194 18946854-3 2008 Recent research has demonstrated that highly reactive nitrates, such as nitroglycerin (or glyceryl trinitrate) and pentaerthrityl tetranitrate (PETN) are bioactivated by aldehyde dehydrogenase 2 (ALDH-2), an enzyme located in mitochondria. Nitrates 54-62 aldehyde dehydrogenase 2 family member Homo sapiens 196-202 18959330-7 2008 We found that the Upper Snake had surprisingly high biotic demand relative to smaller streams in the same river network for both ammonium (NH4+) and nitrate (NO3-). Nitrates 149-156 NBL1, DAN family BMP antagonist Homo sapiens 158-161 18155958-5 2008 RESULTS: In the exposed area, nitrate concentration was measured in 78 wells and ranged from 15.39 to 246.90mg/l as NO3-. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 116-119 18155958-10 2008 Mean MetHb was normal when the nitrate concentration in water was below 50mg/l as NO3-, and reached an abnormal level, when the nitrate concentration in water ranged between 50 and 90mg/l as NO3-. Nitrates 31-38 hemoglobin subunit gamma 2 Homo sapiens 5-10 18155958-11 2008 This last level was statistically similar to mean MetHb at nitrate level above 90mg/l as NO3- (up to 246.9mg/l as NO3-). Nitrates 59-66 hemoglobin subunit gamma 2 Homo sapiens 50-55 18155958-11 2008 This last level was statistically similar to mean MetHb at nitrate level above 90mg/l as NO3- (up to 246.9mg/l as NO3-). Nitrates 59-66 NBL1, DAN family BMP antagonist Homo sapiens 89-92 18563586-1 2008 CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 6-14 18563586-1 2008 CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 125-129 18563586-2 2008 CHL1 expressed in a Hansenula polymorpha high-affinity nitrate-transporter deficient mutant (Deltaynt1) restores nitrate uptake and growth. Nitrates 55-62 DNA helicase Saccharomyces cerevisiae S288C 0-4 18563586-3 2008 These events take place at nitrate concentrations as low as 500 microM, suggesting that CHL1 has a high-affinity for nitrate in yeast. Nitrates 27-34 DNA helicase Saccharomyces cerevisiae S288C 88-92 18956101-6 2008 Molecular dynamics (MD) simulations show that as the Cl- : NO3- ratio increases, the nitrate ions are drawn closer to the interface due to the existence of a double layer of interfacial Cl- and subsurface Na+. Nitrates 85-92 NBL1, DAN family BMP antagonist Homo sapiens 59-62 18563586-3 2008 These events take place at nitrate concentrations as low as 500 microM, suggesting that CHL1 has a high-affinity for nitrate in yeast. Nitrates 117-124 DNA helicase Saccharomyces cerevisiae S288C 88-92 18563586-4 2008 Accordingly, CHL1 expressed in H. polymorpha presents a K(m) for nitrate of about 125 microM. Nitrates 65-72 DNA helicase Saccharomyces cerevisiae S288C 13-17 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 15-22 DNA helicase Saccharomyces cerevisiae S288C 28-32 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 15-22 DNA helicase Saccharomyces cerevisiae S288C 80-84 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 15-22 DNA helicase Saccharomyces cerevisiae S288C 80-84 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 130-137 DNA helicase Saccharomyces cerevisiae S288C 28-32 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 130-137 DNA helicase Saccharomyces cerevisiae S288C 80-84 18563586-5 2008 The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction. Nitrates 130-137 DNA helicase Saccharomyces cerevisiae S288C 80-84 18563586-7 2008 Given that CHL1 presented high affinity by nitrate, we study the role of CHL1 Thr101 in yeast. Nitrates 43-50 DNA helicase Saccharomyces cerevisiae S288C 11-15 18563586-9 2008 Yeast strains expressing CHL1Thr101Ala, CHL1Thr101Asp and CHL1 at the same rate showed that Deltaynt1CHL1Thr101Ala is strikingly unable to transport nitrate and contains a very low amount of CHL1 protein; however, Deltaynt1CHL1Thr101Asp restores nitrate uptake and growth, although no significant changes in nitrate affinity were observed. Nitrates 246-253 DNA helicase Saccharomyces cerevisiae S288C 25-29 18563586-9 2008 Yeast strains expressing CHL1Thr101Ala, CHL1Thr101Asp and CHL1 at the same rate showed that Deltaynt1CHL1Thr101Ala is strikingly unable to transport nitrate and contains a very low amount of CHL1 protein; however, Deltaynt1CHL1Thr101Asp restores nitrate uptake and growth, although no significant changes in nitrate affinity were observed. Nitrates 246-253 DNA helicase Saccharomyces cerevisiae S288C 25-29 18563586-11 2008 The functional expression of CHL1 in H. polymorpha reveals that this yeast is a suitable tool for evaluating the real nitrate transport capacity of plant putative nitrate transporters belonging to different families and study their regulation and structure function relationship. Nitrates 118-125 DNA helicase Saccharomyces cerevisiae S288C 29-33 18563586-11 2008 The functional expression of CHL1 in H. polymorpha reveals that this yeast is a suitable tool for evaluating the real nitrate transport capacity of plant putative nitrate transporters belonging to different families and study their regulation and structure function relationship. Nitrates 163-170 DNA helicase Saccharomyces cerevisiae S288C 29-33 18685092-5 2008 Cardiac-specific eNOS overexpression resulted in significant increases in nitrite, nitrate, and nitrosothiols in the heart, plasma, and liver. Nitrates 83-90 nitric oxide synthase 3, endothelial cell Mus musculus 17-21 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 54-61 interferon regulatory factor 6 Homo sapiens 5-8 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 54-61 interferon gamma Homo sapiens 13-22 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 54-61 nitric oxide synthase 2 Homo sapiens 30-34 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 182-189 interferon regulatory factor 6 Homo sapiens 5-8 18572022-6 2008 Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate. Nitrates 182-189 interferon gamma Homo sapiens 13-22 18394025-9 2008 RESULTS: Despite similar infarct size, deficiency in iNOS resulted in significantly lower plasma nitrate/nitrite levels, better haemodynamic performance and lower mortality 2 weeks after coronary ligation. Nitrates 97-104 nitric oxide synthase 2, inducible Mus musculus 53-57 18800519-1 2008 In the Rocky Mountains, there is uncertainty about the source areas and emission types that contribute to nitrate (NO3) deposition, which can adversely affect sensitive aquatic habitats of high-elevation watersheds. Nitrates 106-113 NBL1, DAN family BMP antagonist Homo sapiens 115-118 18780802-0 2008 Mutation of the Arabidopsis NRT1.5 nitrate transporter causes defective root-to-shoot nitrate transport. Nitrates 35-42 nitrate transporter 1.1 Arabidopsis thaliana 28-32 18780802-2 2008 NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 0-4 18780802-2 2008 NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 65-69 18780802-2 2008 NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 125-131 18780802-2 2008 NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 133-137 18780802-2 2008 NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake. Nitrates 45-52 nitrate transporter 1:2 Arabidopsis thaliana 168-174 18780802-5 2008 Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 35-39 18780802-5 2008 Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 128-132 18780802-5 2008 Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate. Nitrates 173-180 nitrate transporter 1.1 Arabidopsis thaliana 35-39 18780802-5 2008 Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate. Nitrates 173-180 nitrate transporter 1.1 Arabidopsis thaliana 128-132 18780802-7 2008 These data suggest that, in addition to that involving NRT1.5, another mechanism is responsible for xylem loading of nitrate. Nitrates 117-124 nitrate transporter 1.1 Arabidopsis thaliana 55-59 18780802-8 2008 Further analyses of the nrt1.5 mutants revealed a regulatory loop between nitrate and potassium at the xylem transport step. Nitrates 74-81 nitrate transporter 1.1 Arabidopsis thaliana 24-28 18501719-6 2008 Mice deficient in endothelial nitric oxide synthase (eNOS-/-) demonstrated decreased blood and tissue nitrite, nitrate, and nitroso proteins, which were further reduced by low-nitrite (NOx) diet for 1 week. Nitrates 111-118 nitric oxide synthase 3, endothelial cell Mus musculus 18-51 18455513-7 2008 RESULTS: We found significant negative correlations between pro-MMP-9 levels and plasma nitrite (P=0.035, rs= -0.159), nitrate (P=0.040, rs= -0.158), and cGMP (P=0.011, rs= -0.189) concentrations. Nitrates 119-126 matrix metallopeptidase 9 Homo sapiens 64-69 18522491-3 2008 Nitrate tolerance was induced by nitroglycerin infusion in male Wistar rats (100 microg/h/4 day) and in C57/Bl6, p47(phox/) and gp91(phox/) mice (50 microg/h/4 day). Nitrates 0-7 NSFL1 cofactor Rattus norvegicus 113-116 17462814-3 2008 The methodology is demonstrated by applying it separately to a set of general water quality indicators (total suspended solids, biochemical and chemical oxygen demand, nitrates, phosphates and faecal coliforms) to produce a ranked list of BMP pollutant removal efficiencies. Nitrates 168-176 bone morphogenetic protein 1 Homo sapiens 239-242 18384503-4 2008 The subsequent return to a complete medium (containing nitrate) restored expression of all three AS genes. Nitrates 55-62 asparagine synthetase Glycine max 97-99 18384503-9 2008 It is concluded that nitrate (or one of its assimilatory products) leads to the induction of AS in roots of soybean and that this underlies the variations found in xylem sap Asn/Asp ratios. Nitrates 21-28 asparagine synthetase Glycine max 93-95 18367148-10 2008 RESULTS: APC treatment significantly reduced activities of oxidative enzymes and nitrate/nitrite levels in the lung tissues, and plasma levels of proinflammatory cytokines and D-dimer, and also significantly increased activities of antioxidative enzymes (P < .05). Nitrates 81-88 APC regulator of WNT signaling pathway Rattus norvegicus 9-12 18594707-2 2008 Among two series of Ln(III) nitrate complexes (Ln = Pr, Nd, Sm, Eu, Gd, Tb or Dy) which have been characterized by elemental analyses, XRD, TGA and IR spectra, three new coordination polymers have been determined by X-ray diffraction analysis. Nitrates 28-35 T-box transcription factor 1 Homo sapiens 140-143 18557906-1 2008 A full-length cDNA encoding a putative high-affinity nitrate transporter (ZmNrt2.2) from maize was isolated and characterised, together with another previously identified transporter (ZmNrt2.1), in terms of phylogenesis, protein structure prediction and regulation of transcript accumulation in response to nitrate and sugar availability. Nitrates 53-60 putative high affinity nitrate transporter Zea mays 74-82 18557906-3 2008 Data obtained suggested similar genetic evolution and identical transmembrane structure prediction between the two deduced proteins, and differences in both regulation of their expression and mRNA localisation in response to nitrate, leading us to hypothesise a principal role for ZmNRT2.1 in the influx activity and the major involvement of ZmNRT2.2 in the xylem loading process. Nitrates 225-232 nitrate transport 2 Zea mays 281-289 18557906-4 2008 Our data suggest opposing sugar regulation by ZmNrt2.1 and ZmNrt2.2 transcription in the presence or absence of nitrate and the existence of both hexokinase-dependent and hexokinase-independent transduction mechanisms for the regulation of ZmNrt2.1 and ZmNrt2.2 expression by sugars. Nitrates 112-119 nitrate transport 2 Zea mays 46-54 18557906-4 2008 Our data suggest opposing sugar regulation by ZmNrt2.1 and ZmNrt2.2 transcription in the presence or absence of nitrate and the existence of both hexokinase-dependent and hexokinase-independent transduction mechanisms for the regulation of ZmNrt2.1 and ZmNrt2.2 expression by sugars. Nitrates 112-119 putative high affinity nitrate transporter Zea mays 59-67 18499297-9 2008 Dissolved RDX samples were degraded in the laboratory and results showed that all reproduced degradation processes released nitrate with a strong fractionation. Nitrates 124-131 radixin Homo sapiens 10-13 18499297-10 2008 Laboratory isotopic values for RDX-derived NO(3)(-) produced a trend of high delta(18)O-low delta(15)N to low delta(18)O-high delta(15)N, and groundwater samples with nitrate concentrations above the expected background level appeared along this trend. Nitrates 167-174 radixin Homo sapiens 31-34 18499297-11 2008 Our results thus point toward a characteristic field of isotopic ratios for nitrate being derived from the degradation of RDX. Nitrates 76-83 radixin Homo sapiens 122-125 18702296-4 2008 Nitrate and organic matter expressed as dissolved organic carbon were 50 mgl(-1) and 20 mgl(-1), respectively, in the inlet. Nitrates 0-7 LLGL scribble cell polarity complex component 1 Homo sapiens 73-79 18702296-4 2008 Nitrate and organic matter expressed as dissolved organic carbon were 50 mgl(-1) and 20 mgl(-1), respectively, in the inlet. Nitrates 0-7 LLGL scribble cell polarity complex component 1 Homo sapiens 88-94 18417639-3 2008 In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI. Nitrates 122-129 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 83-86 32688789-5 2008 Transcript levels of NR (nitrate reductase) and its cofactor binding domain genes FAD (FAD binding) and CYP51G1 (Heme binding), the activity of nitrate reductase (NR, EC 1.6.6.1) and the nitrate reduction process were each greatly enhanced by Put application, particularly in roots exposed to hypoxia. Nitrates 25-32 nitrate reductase [NADH]-like Cucumis sativus 21-23 32688789-8 2008 These results suggest that Put enhances tolerance to hypoxia by increasing the transcript levels of NR and its cofactor binding domain genes, thereby stimulating the activities of NR and nitrate reduction to maintain the redox and energy status. Nitrates 187-194 nitrate reductase [NADH]-like Cucumis sativus 100-102 18266918-0 2008 Nitrate signalling mediated by the NRT1.1 nitrate transporter antagonises L-glutamate-induced changes in root architecture. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 35-41 18417639-3 2008 In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI. Nitrates 122-129 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 116-120 18417639-3 2008 In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI. Nitrates 122-129 K-box region and MADS-box transcription factor family protein Arabidopsis thaliana 202-205 18546685-1 2008 Aerobic conditions in desert aquifers commonly allow high nitrate (NO3-) concentrations in recharge to persist for long periods of time, an important consideration for N-cycling and water quality. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrates 90-97 progesterone receptor Homo sapiens 190-211 18329686-3 2008 Elevated nutrients were found in all wells where significant concentrations of both tracers were observed, with the mean of the highest nitrate (NO3) concentration observed at each well being 47.8+/-14.9 (n=11) mg/L NO3-N. Nitrates 136-143 NBL1, DAN family BMP antagonist Homo sapiens 145-148 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrates 90-97 progesterone receptor Homo sapiens 213-216 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrates 90-97 trefoil factor 1 Homo sapiens 219-222 18483281-2 2008 Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780. Nitrates 90-97 cathepsin D Homo sapiens 228-239 18483281-5 2008 The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERalpha suggests that nitrite is the active anion. Nitrates 59-66 progesterone receptor Homo sapiens 105-108 18483281-5 2008 The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERalpha suggests that nitrite is the active anion. Nitrates 59-66 estrogen receptor 1 Homo sapiens 158-165 18453433-1 2008 Physical, chemical, hydrologic, and biologic factors affecting nitrate (NO3(-)) removal were evaluated in three agricultural streams draining orchard/dairy and row crop settings. Nitrates 63-70 NBL1, DAN family BMP antagonist Homo sapiens 72-75 18453433-9 2008 Nitrate retention as a percentage of gross NO3(-) inputs was >30% in an organic-poor, autotrophic stream with the lowest denitrification potentials and highest benthic chlorophyll a, photosynthesis/respiration ratio, pH, dissolved oxygen, and diurnal NO3(-) variation. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 43-46 18453433-9 2008 Nitrate retention as a percentage of gross NO3(-) inputs was >30% in an organic-poor, autotrophic stream with the lowest denitrification potentials and highest benthic chlorophyll a, photosynthesis/respiration ratio, pH, dissolved oxygen, and diurnal NO3(-) variation. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 254-257 18655580-2 2008 On the 7th day under nitrate stress, the shoot fresh mass per plant decreased by 12.77 g, leaf SOD, POD and CAT activities increased, while leaf APX, DHAR and GR activities decreased significantly, compared with the control. Nitrates 21-28 catalase isozyme 1 Cucumis sativus 108-111 18284212-5 2008 Of the anions studied, particularly intriguing in terms of observed trends in substrate kinetics and their novel atomic compositions were the nitrite, nitrate, and azide anions, the latter of which was found to enhance the relative activity of human pancreatic alpha-amylase by nearly 5-fold. Nitrates 151-158 amylase alpha 2A Homo sapiens 250-274 18213641-9 2008 Exposure to arsenic compounds, chlorophenols, diesel fuel, herbicides, nitrites/nitrates/nitrosamines, and organic dusts were associated with NHL(high) and NHL(low), while exhibiting little association with CLL. Nitrates 80-88 regulator of telomere elongation helicase 1 Homo sapiens 142-145 18713378-4 2008 The present study identified four putative NRT2 and two putative NAR2 genes that encode components of the high-affinity nitrate transport system (HATS) in the rice (Oryza sativa L. subsp. Nitrates 120-127 nitrate transporter 2:1 Arabidopsis thaliana 43-47 17923423-5 2008 RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production. Nitrates 164-171 tumor necrosis factor Bos taurus 9-18 17923423-5 2008 RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production. Nitrates 164-171 interleukin 1 beta Bos taurus 23-31 18714730-7 2008 Pre-block of ACE by captopril intensified diuresis and inhibited renal excretion of OAS, nitrites and nitrates in response to T4 injection. Nitrates 102-110 angiotensin I converting enzyme Rattus norvegicus 13-16 18326829-8 2008 The hot5 null alleles show increased nitrate and nitroso species levels, and the heat sensitivity of both missense and null alleles is associated with increased NO species. Nitrates 37-44 GroES-like zinc-binding dehydrogenase family protein Arabidopsis thaliana 4-8 18158911-5 2008 Nitric oxide has been reported to react easily with oxygen captured in hemoglobin to form nitrate, but not toxic free radicals, which may result in production of methemoglobin for the cytochrome b5 to regenerate functional ferrous hemoglobin. Nitrates 90-97 hemoglobin subunit gamma 2 Homo sapiens 162-175 18164678-2 2008 Electron density maps obtained from crystals grown in presence of Al(NO3)3 show a nitrate ion instead of the expected AlF4- in the catalytic site. Nitrates 82-89 NBL1, DAN family BMP antagonist Homo sapiens 69-72 18341112-6 2008 Seasonal variation in TOC was mainly climatically controlled, whereas deposition of sulfate and nitrate (NO3) explained the long-term TOC increase. Nitrates 96-103 NBL1, DAN family BMP antagonist Homo sapiens 105-108 18061242-4 2008 It is further demonstrated that reactions in/on sea-spray affect the entire particle ensemble and particularly the size distribution of particle nitrate, but that the importance of these heterogeneous reactions is critically dependent on both the initial vertical profile of sea spray and the sea-spray source functions. Nitrates 145-152 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 48-51 18266427-0 2008 High field 207Pb spin-lattice relaxation in solid lead nitrate and lead molybdate. Nitrates 55-62 spindlin 1 Homo sapiens 17-21 18164136-6 2008 Furthermore, at 4 weeks, the nNOS protein content and NO production as reflected by the concentration of nitrite and nitrate were drastically elevated as measured by Western blot analysis and NO colorimetric assay, respectively. Nitrates 117-124 nitric oxide synthase, brain Cavia porcellus 29-33 18341114-5 2008 For nitrate (NO3) and ammonium in runoff, the reverse is true. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 13-16 18341115-3 2008 Increased soil temperatures during winter increased the springtime concentrations and fluxes of ammonium (NH4) and nitrate (NO3) in runoff. Nitrates 115-122 NBL1, DAN family BMP antagonist Homo sapiens 124-127 18341119-1 2008 The mass transport model TEOTIL was used to project nitrate (NO3) fluxes from the Tovdal River basin, southernmost Norway, given four scenarios of climate change. Nitrates 52-59 NBL1, DAN family BMP antagonist Homo sapiens 61-64 18157715-1 2008 This article presents the results of mass concentration of major acidic anions (chlorides, nitrates and sulphates) in TSP and PM(10) particle fraction in Zagreb air measured continuously at one measuring site in 2004. Nitrates 91-99 thrombospondin 1 Homo sapiens 118-121 18037907-9 2008 CONCLUSIONS AND IMPLICATIONS: Nitrate tolerance induced by NTG at low concentrations may result from an increased production of reactive oxygen species acting on sites upstream of PKG. Nitrates 30-37 protein kinase cGMP-dependent 1 Homo sapiens 180-183 18817197-6 2008 Chloride (Cl) and nitrate (NO3) concentrations were higher than the permissible limits according to World Health Organization Standards. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 18199125-2 2008 This process is carried out by two heterotetrameric enzymes that catalyse the oxidation of NADH (Nrc) and the reduction of nitrate (Nar), whose expression is activated by the NCE-encoded transcription factors DnrS and DnrT. Nitrates 123-130 nuclear receptor coactivator 6 Homo sapiens 97-100 18199125-4 2008 We encountered that nrc mutants of denitrifying strains show a decrease in anaerobic growth rates not only with nitrate, but also with nitrite, NO and N(2)O, which is concomitant to their lower NADH oxidation activities in vitro. Nitrates 112-119 nuclear receptor coactivator 6 Homo sapiens 20-23 18199125-5 2008 We show that nitrate, nitrite and NO are activating signals for transcription of nrc in these strains. Nitrates 13-20 nuclear receptor coactivator 6 Homo sapiens 81-84 18078452-5 2008 Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium. Nitrates 120-127 interferon gamma Rattus norvegicus 19-28 18006476-5 2008 METHODS AND RESULTS: Treatment of vascular EC with a FXR ligand resulted in upregulation of expression of eNOS mRNA and protein and an increased production of nitrite/nitrate. Nitrates 167-174 nuclear receptor subfamily 1, group H, member 4 Rattus norvegicus 53-56 17938848-3 2008 Recent studies revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role for the development of nitrate and crosstolerance. Nitrates 126-133 aldehyde dehydrogenase 2 family member Homo sapiens 187-193 17938848-4 2008 The present review focuses firstly on the role of ALDH-2 for organic nitrate bioactivation and secondly on the role of oxidative stress in the development of tolerance and cross-tolerance (endothelial dysfunction) in response to various organic nitrates. Nitrates 69-76 aldehyde dehydrogenase 2 family member Homo sapiens 50-56 19213313-1 2008 The interactions of nitrate with Cu(100) and Cu(111) in acidic solution are studied by cyclic voltammetry (CV) and in situ electrochemical scanning tunneling microscopy (EC-STM). Nitrates 20-27 sulfotransferase family 1A member 3 Homo sapiens 173-176 18267946-0 2008 Senescence-induced ectopic expression of the A. tumefaciens ipt gene in wheat delays leaf senescence, increases cytokinin content, nitrate influx, and nitrate reductase activity, but does not affect grain yield. Nitrates 131-138 Ipt Agrobacterium tumefaciens 60-63 18078452-5 2008 Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium. Nitrates 120-127 nitric oxide synthase 2 Rattus norvegicus 76-80 18181234-2 2008 The method is composed of the traditional oxidation/reduction methods, such as the oxidation of PON to nitrate (NO3*) using persulfate, the reduction of NO3* to nitrite (NO2*) using spongy cadmium, and further reduction of NO2* to nitrous oxide (N2O) using sodium azide. Nitrates 103-110 NBL1, DAN family BMP antagonist Homo sapiens 112-115 22062097-5 2008 Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat. Nitrates 59-66 myoglobin Homo sapiens 193-202 18077439-7 2007 Molybdate uptake mediated by MOT1 showed a K(m) of approximately 6 nM, which is the range of the lowest K(m) values reported and was activated in the presence of nitrate. Nitrates 162-169 DNA-binding ATPase Saccharomyces cerevisiae S288C 29-33 18441434-0 2008 Effect of nitrate on the reduction of Reactive Red 2 by mesophilic anaerobic sludge. Nitrates 10-17 adenosine deaminase RNA specific B2 (inactive) Homo sapiens 47-52 17492487-1 2007 Water with high nitrate concentration (NO(3) (-)) is unfit for human consumption, especially when its concentration exceeded the threshold limit (50 mg/l) recommended by the health authorities such as the World Health Organization (WHO). Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 39-44 18213972-1 2007 A century-long increase in nitrate (NO3-) in the water column of Lake Superior is a classic example of recent nitrogen accumulation in ecosystems, but its cause and relationship to historical NO3- deposition is unknown. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 36-39 18024571-0 2007 Nitrate signaling by the regulatory gene NIT2 in Chlamydomonas. Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 41-45 18041625-5 2007 Anthropogenic impact was detected only in a tributary stream of the River Sava, which is located in an agriculture-industrial area and is reflected in higher delta(15)N values in suspended matter and high nitrate concentrations in the late summer season. Nitrates 205-212 T-box transcription factor T Homo sapiens 74-78 17898699-4 2007 Repeated intravenous doses of cationized catalase significantly decreased cisplatin-induced changes in serum creatinine, blood urea nitrogen, nitrite/nitrate levels, lactic dehydrogenase activity, and renal total glutathione and malondialdehyde contents. Nitrates 150-157 catalase Mus musculus 41-49 17958340-1 2007 The photolysis wavelength dependence of the nitrate radical quantum yield for peroxyacetyl nitrate (CH(3)C(O)OONO(2), PAN) is investigated. Nitrates 44-51 adenosine deaminase 2 Homo sapiens 118-121 17958340-3 2007 We find the nitrate radical quantum yield from PAN photolysis to be essentially invariant; Phi(NO3)(PAN) = 0.30 +/- 0.07 (+/-2sigma) in this region. Nitrates 12-19 adenosine deaminase 2 Homo sapiens 47-50 18044493-5 2007 For an average fertilizer application rate of 90 kg of N/ha, the simulated nitrate concentration on Oct 1 within the top 1 m of soil is 33 mg of N/kg, while the residual soil nitrate measured in late September was 37 mg of N/kg. Nitrates 75-82 solute carrier family 22 member 1 Homo sapiens 100-105 17948780-1 2007 We used the dual isotope approach to identify sources of nitrate (NO3-) to two mixed land-use watersheds draining to Long Island Sound. Nitrates 57-64 NBL1, DAN family BMP antagonist Homo sapiens 66-69 31348636-6 2019 Adsorption experiment with anions such as phosphate (HPO42-) and nitrate (NO3-) was conducted by using ClO4-roseLDH and Cl-roseLDH. Nitrates 65-72 NBL1, DAN family BMP antagonist Homo sapiens 74-77 18852825-0 2007 Structural and Physical Characterization of (Nitrato)iron(III) Porphyrinates [Fe(por)(NO(3))] - Variable Coordination of Nitrate. Nitrates 121-128 cytochrome p450 oxidoreductase Homo sapiens 81-84 17672841-5 2007 Expression of the AtDUR3 gene in nitrogen-deficient roots was repressed by ammonium and nitrate but induced after supply of urea. Nitrates 88-95 urea-proton symporter DEGRADATION OF UREA 3 (DUR3) Arabidopsis thaliana 18-24 17585900-9 2007 The present results suggest that nitrate tolerance is, at least partially, associated with a decrease in endogenous CGRP release via a decrease in ALDH-2 activity as a result of stimulation of reactive oxygen species production. Nitrates 33-40 calcitonin related polypeptide alpha Homo sapiens 116-120 17585900-9 2007 The present results suggest that nitrate tolerance is, at least partially, associated with a decrease in endogenous CGRP release via a decrease in ALDH-2 activity as a result of stimulation of reactive oxygen species production. Nitrates 33-40 aldehyde dehydrogenase 2 family member Homo sapiens 147-153 18024571-3 2007 Each of these 10 lines was mutated in the nitrate assimilation-specific regulatory gene NIT2. Nitrates 42-49 uncharacterized protein Chlamydomonas reinhardtii 88-92 18024571-6 2007 NIT2 expression is negatively regulated by ammonium and is optimal in N-free medium with no need for the presence of nitrate. Nitrates 117-124 uncharacterized protein Chlamydomonas reinhardtii 0-4 18024571-7 2007 However, intracellular nitrate is required to allow Nit2 to activate the NIA1 promoter activity. Nitrates 23-30 uncharacterized protein Chlamydomonas reinhardtii 52-56 18024571-9 2007 Our data indicate that NIT2 is a central regulatory gene required for nitrate signaling on the Chlamydomonas NIA1 gene promoter and that intracellular nitrate is needed for NIT2 function and to modulate NIA1 transcript levels. Nitrates 70-77 uncharacterized protein Chlamydomonas reinhardtii 23-27 18024571-9 2007 Our data indicate that NIT2 is a central regulatory gene required for nitrate signaling on the Chlamydomonas NIA1 gene promoter and that intracellular nitrate is needed for NIT2 function and to modulate NIA1 transcript levels. Nitrates 151-158 uncharacterized protein Chlamydomonas reinhardtii 173-177 17555556-6 2007 Motoneuron survival was inversely correlated with nitrate + nitrite concentrations in mSOD1(G93A) co-cultures, suggesting the important role of nitric oxide in microglia-induced motoneuron injury. Nitrates 50-57 superoxide dismutase 1, soluble Mus musculus 86-91 17709521-8 2007 The NOS2 genotype observed in healthy controls was correlated with an increase in NOS2 expression and higher concentrations of nitrate and nitrite in control serum. Nitrates 127-134 nitric oxide synthase 2 Homo sapiens 4-8 17541025-8 2007 CONCLUSIONS: HO-1 expression and activity appear to play a key role in the development of nitrate tolerance and might represent an intrinsic antioxidative mechanism of therapeutic interest. Nitrates 90-97 heme oxygenase 1 Rattus norvegicus 13-17 17766834-8 2007 The timing of P release was inversely related to the nitrate (NO3-) concentration in floodwater. Nitrates 53-60 NBL1, DAN family BMP antagonist Homo sapiens 62-65 17611046-1 2007 Escherichia coli flavohaemoglobin (Hmp) is the best-understood nitric oxide (NO) detoxifying protein and exhibits a robust dioxygenase activity, converting NO to nitrate ion with oxygen as co-substrate. Nitrates 162-169 inner membrane mitochondrial protein Homo sapiens 35-38 17655297-1 2007 Nitrate adsorption and reduction on Cu(100) in acidic solution is studied by electrochemical methods, in situ electrochemical scanning tunneling microscopy (EC-STM), surface enhanced Raman spectroscopy (SERS), and density functional theory (DFT) calculations. Nitrates 0-7 sulfotransferase family 1A member 3 Homo sapiens 160-163 17655297-2 2007 Electrochemical results show that reduction of nitrate starts at -0.3 V vs Ag/AgCl and reaches maximum value at -0.58 V. Over the entire potential region interrogated adlayers composed of nitrate, nitrite, or other intermediates are observed by using in situ STM. Nitrates 47-54 sulfotransferase family 1A member 3 Homo sapiens 259-262 17573350-0 2007 Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana. Nitrates 19-26 nitrate transporter 2:1 Arabidopsis thaliana 41-47 17573350-1 2007 In Arabidopsis the NRT2.1 gene encodes a main component of the root high-affinity nitrate uptake system (HATS). Nitrates 82-89 nitrate transporter 2:1 Arabidopsis thaliana 19-25 17541025-0 2007 Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates. Nitrates 92-100 heme oxygenase 1 Rattus norvegicus 0-16 17541025-1 2007 OBJECTIVE: Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling. Nitrates 11-18 aldehyde dehydrogenase 2 family member Rattus norvegicus 144-180 17541025-1 2007 OBJECTIVE: Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling. Nitrates 11-18 aldehyde dehydrogenase 2 family member Rattus norvegicus 182-188 17526746-6 2007 Interestingly, the membrane nitrate reductase mutant was avirulent in C. elegans, while nitrate sensor-response regulator mutants were fully virulent. Nitrates 28-35 reductase Pseudomonas aeruginosa PAO1 36-45 17559573-2 2007 Extracts of maltose/yeast extract/nitrate-grown cells contained all enzyme activities of a modified Embden-Meyerhof (EM) pathway, including ATP-dependent glucokinase, phosphoglucose isomerase, ATP-dependent 6-phosphofructokinase, fructose-1,6-phosphate aldolase, triose-phosphate isomerase, GAPOR, phosphoglycerate mutase, enolase and pyruvate kinase. Nitrates 34-41 phosphoglycerate mutase Saccharomyces cerevisiae S288C 298-321 17622411-5 2007 On the average, the dissociated nitrate interacts with 2 to 4 cs3 molecules, whereas the associated nitrate (LCs(+)NO(3)(-) complex) interacts with one cs3 dimer. Nitrates 32-39 myozenin 3 Homo sapiens 62-65 17722702-5 2007 In the presence of high levels of nitrate or ammonium, the NIN gene fails to be induced 24 h after the addition of Nod factor compared with plants grown under N-free conditions. Nitrates 34-41 nin Lotus japonicus 59-62 17722702-6 2007 This induction is restored in the hypernodulating nitrate-tolerant har1-3 mutant only in the presence of 10 and 20 mM KNO3. Nitrates 50-57 CM0216.560.nc Lotus japonicus 67-71 17722702-8 2007 NIN plays a key role in the nodule organogenesis program and its downregulation may represent a crucial event in the nitrate-dependent pathway leading to the inhibition of nodule organogenesis. Nitrates 117-124 nin Lotus japonicus 0-3 17606840-10 2007 The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2. Nitrates 89-97 nitric oxide synthase 3, endothelial cell Mus musculus 15-19 17606840-10 2007 The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2. Nitrates 89-97 prostaglandin-endoperoxide synthase 2 Mus musculus 121-137 17622411-5 2007 On the average, the dissociated nitrate interacts with 2 to 4 cs3 molecules, whereas the associated nitrate (LCs(+)NO(3)(-) complex) interacts with one cs3 dimer. Nitrates 100-107 myozenin 3 Homo sapiens 152-155 17571880-3 2007 A second, and sometimes third, oxidation peak was also observed when the anodic limit was extended, and these were provisionally assigned to the oxidation of nitrogen dioxide (NO2) and nitrate (NO3-), respectively. Nitrates 185-192 NBL1, DAN family BMP antagonist Homo sapiens 194-197 17475504-8 2007 Levels of circulating nitrite/nitrate, the end-metabolites of nitric oxide, were also significantly affected by ACE inhibition, with the same order of potency. Nitrates 30-37 angiotensin I converting enzyme Rattus norvegicus 112-115 17467673-6 2007 PDE1 and/or PDE5 are also reportedly up-regulated in chronic disease conditions such as atherosclerosis or cardiac pressure-load stress and heart failure as well as in response to long-term exposure to nitrates. Nitrates 202-210 phosphodiesterase 5A Homo sapiens 12-16 19704673-3 2007 Using heterologous expression in yeast and oocytes we showed that the two Arabidopsis AtNRT2.1 and AtNAR2.1 proteins interacted to give a functional high affinity nitrate transport system (HATS). Nitrates 163-170 nitrate transporter 2:1 Arabidopsis thaliana 86-94 17559208-3 2007 Three novel crystal structures and FT-IR spectra of metal nitrate-galactitol complexes of La(NO3)3.C6H14O6. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 93-96 17347445-8 2007 There was a trend toward enhanced production of nitrate relative to nitrite as an end product of NO metabolism in IL-13-stimulated cells. Nitrates 48-55 interleukin 13 Homo sapiens 114-119 17566055-9 2007 CsNitr1-L may possibly load cytosolic nitrite into chloroplast stroma in the chloroplast envelope during nitrate assimilation. Nitrates 105-112 probable nitrite transporter At1g68570-like Cucumis sativus 0-7 17482833-1 2007 Exposure to nitrates causes tachyphylaxis to nitric oxide (NO), which reduces the effects of the second messenger cyclic guanosine-3",-5"-monophosphate (cyclic GMP). Nitrates 12-20 5'-nucleotidase, cytosolic II Homo sapiens 160-163 17336418-8 2007 PPT/DPN reduced nitrate/nitrite production and iNOS mRNA in Kupffer cells following trauma-hemorrhage; however, these levels in DPN-treated animals remained higher than sham. Nitrates 16-23 tachykinin, precursor 1 Rattus norvegicus 0-3 17523628-3 2007 According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, a change in free energy of +6 kcal/mol is predicted for eta(2)- to eta(1)-transition of one of the three nitrate ligands in the gas phase. Nitrates 208-215 DNA polymerase iota Homo sapiens 159-165 17523628-3 2007 According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, a change in free energy of +6 kcal/mol is predicted for eta(2)- to eta(1)-transition of one of the three nitrate ligands in the gas phase. Nitrates 208-215 secreted phosphoprotein 1 Homo sapiens 170-176 17523628-5 2007 This contrasts with the aqueous solution where the nitrate binds in a eta(1)-fashion and uranyl coordinates to four H2O ligands. Nitrates 51-58 secreted phosphoprotein 1 Homo sapiens 70-76 17523628-9 2007 The [UO(2)(NO(3))(4)](2-) complex with two eta(2)- and two eta(1)- coordinated nitrates, observed in the solid state, is stable for 1-2 ps in the gas phase and in solution. Nitrates 79-87 secreted phosphoprotein 1 Homo sapiens 59-65 17503808-4 2007 The addition of Cl- anions promotes the solubilization of the nitrate and triflate salts in the C4mimPF6 and the C4mimBF4 ILs via the formation of chloro complexes, also formed with other salts. Nitrates 62-69 complement C4A (Rodgers blood group) Homo sapiens 96-104 17277235-7 2007 We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form. Nitrates 51-58 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 84-90 17277235-7 2007 We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form. Nitrates 51-58 nocturnin Homo sapiens 135-138 17548042-4 2007 As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge. Nitrates 94-101 interleukin 1 alpha Mus musculus 149-158 17493633-0 2007 Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation. Nitrates 35-42 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 92-116 17493633-3 2007 Using cell culture and animal models of nitrate tolerance, we aimed to assess the impact of nitrates on NAD(P)H oxidases and aldehyde dehydrogenase 2 (ALDH2) expression. Nitrates 92-100 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 125-149 17493633-3 2007 Using cell culture and animal models of nitrate tolerance, we aimed to assess the impact of nitrates on NAD(P)H oxidases and aldehyde dehydrogenase 2 (ALDH2) expression. Nitrates 92-100 aldehyde dehydrogenase 1 family, member A1 Rattus norvegicus 151-156 17493633-13 2007 In addition, expression and activity of ALDH-2 was decreased in nitrate-tolerant rings. Nitrates 64-71 aldehyde dehydrogenase 2 family member Rattus norvegicus 40-46 17617676-10 2007 Interestingly, the addition of NAC to lead nitrate-treated HepG2 cells significantly decreased cellular content of reactive oxygen species (ROS), as evidenced by the decrease in lipid peroxidation byproducts. Nitrates 43-50 X-linked Kx blood group Homo sapiens 31-34 17617676-11 2007 Overall, findings from this study suggest that NAC inhibits lead nitrate-induced cytotoxicity and oxidative stress in HepG2 cells. Nitrates 65-72 X-linked Kx blood group Homo sapiens 47-50 17548042-4 2007 As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge. Nitrates 94-101 tumor necrosis factor Mus musculus 173-181 17481610-5 2007 Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake. Nitrates 120-127 nitrate transporter 1.1 Arabidopsis thaliana 11-15 17481610-5 2007 Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake. Nitrates 120-127 nitrate transporter 1:2 Arabidopsis thaliana 32-40 17481610-5 2007 Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake. Nitrates 120-127 nitrate transporter 2:1 Arabidopsis thaliana 57-61 17481610-5 2007 Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake. Nitrates 120-127 nitrate transporter 2:1 Arabidopsis thaliana 69-77 17481610-5 2007 Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake. Nitrates 120-127 nitrate transporter 2:1 Arabidopsis thaliana 69-75 17481610-6 2007 In addition, AtNRT1.4 is required for petiole nitrate storage. Nitrates 46-53 nitrate transporter 1.1 Arabidopsis thaliana 13-19 17485712-1 2007 Nitrate (NO3-) leaching to ground water poses water quality concerns in some settings. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 17540716-0 2007 The Arabidopsis ATNRT2.7 nitrate transporter controls nitrate content in seeds. Nitrates 25-32 high affinity nitrate transporter 2.7 Arabidopsis thaliana 16-24 17229473-6 2007 Moreover, leptin increased plasma concentration and urinary excretion of NO metabolites, nitrites+nitrates (NO(x)), and of NO second messenger, cyclic GMP. Nitrates 98-106 leptin Rattus norvegicus 10-16 17183346-3 2007 As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease. Nitrates 87-95 phosphodiesterase 5A Homo sapiens 9-28 17183346-3 2007 As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease. Nitrates 87-95 phosphodiesterase 5A Homo sapiens 30-34 17540716-1 2007 In higher plants, nitrate is taken up by root cells where Arabidopsis thaliana NITRATE TRANSPORTER2.1 (ATNRT2.1) chiefly acts as the high-affinity nitrate uptake system. Nitrates 18-25 nitrate transporter 2:1 Arabidopsis thaliana 79-101 17540716-1 2007 In higher plants, nitrate is taken up by root cells where Arabidopsis thaliana NITRATE TRANSPORTER2.1 (ATNRT2.1) chiefly acts as the high-affinity nitrate uptake system. Nitrates 147-154 nitrate transporter 2:1 Arabidopsis thaliana 79-101 17540716-6 2007 We assessed the capacity of ATNRT2.7 to transport nitrate in Xenopus laevis oocytes or when it is expressed ectopically in mutant plants deficient in nitrate transport. Nitrates 50-57 high affinity nitrate transporter 2.7 Arabidopsis thaliana 28-36 17540716-6 2007 We assessed the capacity of ATNRT2.7 to transport nitrate in Xenopus laevis oocytes or when it is expressed ectopically in mutant plants deficient in nitrate transport. Nitrates 150-157 high affinity nitrate transporter 2.7 Arabidopsis thaliana 28-36 17540716-8 2007 By contrast, seed nitrate content was affected by overexpression of ATNRT2.7 or a mutation in the gene. Nitrates 18-25 high affinity nitrate transporter 2.7 Arabidopsis thaliana 68-76 17540716-10 2007 Our results demonstrate that ATNRT2.7 plays a specific role in nitrate accumulation in the seed. Nitrates 63-70 high affinity nitrate transporter 2.7 Arabidopsis thaliana 29-37 17094870-3 2007 Here, we investigated whether NOS2-mediated nitrite/nitrate synthesis modulates responsiveness to inhaled NO. Nitrates 52-59 nitric oxide synthase 2 Rattus norvegicus 30-34 17306574-2 2007 We evaluated the association of eNOS genotypes/haplotypes with the plasma concentrations of nitrite/nitrate (NO(x)), which are products of nitric oxide in HT, T2DM, and T2DM+HT patients. Nitrates 100-107 nitric oxide synthase 3 Homo sapiens 32-36 17520925-7 2007 In the estuary bay with a long residence time, in the Archipelago Sea, up to 4.5% of nitrate loading and 19% of nitrogen loading were removed before entering the sea. Nitrates 85-92 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 66-69 17696737-2 2007 The aim of the present study was to quantify nitrate+nitrite (NO2+NO3) in tobacco products as well as to study tobacco exposure related biomarkers in controls, patients with oral precancers (OPC) and oral cancer patients. Nitrates 45-52 NBL1, DAN family BMP antagonist Homo sapiens 66-69 17363026-1 2007 In agricultural areas, nitrate (NO3-) is a common groundwater pollutant as a result of extensive fertilizer application. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 32-35 17094870-11 2007 Here, responsiveness to inhaled NO is dependent on the ability of NOS2 inhibitors to reduce nitrite and nitrate levels in serum and released in the lung. Nitrates 104-111 nitric oxide synthase 2 Rattus norvegicus 66-70 17329906-0 2007 Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates. Nitrates 93-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17242981-4 2007 Using the hph-1 mouse, which displays a partial BH4 deficiency owing to impaired activity of GTP cyclohydrolase, we report decreased levels of glutathione in brain and kidney and evidence for decreased basal generation of nitric oxide in the periphery (as judged by the plasma nitrate plus nitrite concentration). Nitrates 277-284 hyperphenylalaninemia 1 Mus musculus 10-15 17242981-6 2007 However, the concentration of plasma nitrate plus nitrite achieved was significantly decreased in the hph-1 mouse. Nitrates 37-44 hyperphenylalaninemia 1 Mus musculus 102-107 17450295-6 2007 As a result, the depth to which dissolved anthropogenic N as nitrate (NO3) is leached early in the winter wet season is limited to within the top approximately 130 cm of soil where it accumulates and increases soil acidity. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 17355433-5 2007 Supplied with insufficient inorganic nitrogen (nitrate or ammonium), the nla mutant failed to develop the essential adaptive responses to nitrogen limitation, but senesced much earlier and more rapidly than did the wild type. Nitrates 47-54 SPX (SYG1/Pho81/XPR1) domain-containing protein Arabidopsis thaliana 73-76 17056288-4 2007 In the present study, we used an ultra-sensitive NO-selective electrochemical sensor (AmiNO700) in combination with a highly efficient nitrate conversion method, which coupled the nitrate reductase step with the glucose-6-phosphate dehydrogenase system. Nitrates 135-142 glucose-6-phosphate dehydrogenase Homo sapiens 212-245 17329906-2 2007 We have previously reported that cytochrome P450 (P450) plays important role in NO generation from other organic nitrates such as nitroglycerin (NTG) and isosorbide dinitrate (ISDN). Nitrates 113-121 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 33-48 17249740-1 2007 Concentrated aqueous nitrate aerosols are present in the Earth"s atmosphere as a result of heterogeneous reactions of sea salt and mineral dust aerosol with nitrogen oxides (e.g., NO2, NO3, HNO3 and N2O5). Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 185-188 17173980-5 2007 CLP led to increased plasma nitrate levels, protein leakage and hypotension and caused mortality of 80% by 24 h. Expression of c-fos in paraventricular (PVN), supraoptic (SON) and organum vasculosum of lamina terminalis (OVLT) nuclei, as well as plasma AVP concentration were increased at 6 h but reduced to basal levels 24 h after CLP. Nitrates 28-35 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 127-132 17275683-12 2007 Inflammatory activity was reduced in the rats receiving nitrate as indicated by lower mucosal myeloperoxidase activity and expression of inducible NO synthase. Nitrates 56-63 myeloperoxidase Rattus norvegicus 94-109 17275683-12 2007 Inflammatory activity was reduced in the rats receiving nitrate as indicated by lower mucosal myeloperoxidase activity and expression of inducible NO synthase. Nitrates 56-63 nitric oxide synthase 2 Rattus norvegicus 137-158 17220910-0 2007 Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice. Nitrates 70-78 aldehyde dehydrogenase 2, mitochondrial Mus musculus 108-114 17220910-1 2007 BACKGROUND AND PURPOSE: Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates. Nitrates 135-143 aldehyde dehydrogenase 2, mitochondrial Mus musculus 62-68 17220910-1 2007 BACKGROUND AND PURPOSE: Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates. Nitrates 233-241 aldehyde dehydrogenase 2, mitochondrial Mus musculus 62-68 17220910-2 2007 We therefore sought to support the hypothesis that bioactivation by ALDH-2 critically depends on the number of nitrate groups within the nitrovasodilator. Nitrates 111-118 aldehyde dehydrogenase 2, mitochondrial Mus musculus 68-74 17220910-10 2007 CONCLUSIONS AND IMPLICATIONS: Our results support the crucial role of ALDH-2 in bioactivating highly reactive nitrates like GTN, PETN and PETriN. Nitrates 110-118 aldehyde dehydrogenase 2, mitochondrial Mus musculus 70-76 17220910-11 2007 ALDH-2-mediated relaxation by organic nitrates therefore depends mainly on the number of nitrate groups. Nitrates 38-46 aldehyde dehydrogenase 2, mitochondrial Mus musculus 0-6 17220910-11 2007 ALDH-2-mediated relaxation by organic nitrates therefore depends mainly on the number of nitrate groups. Nitrates 38-45 aldehyde dehydrogenase 2, mitochondrial Mus musculus 0-6 17265003-5 2007 Denitrification was positively related to nitrate (NO3 ) concentration, suggesting that sediments may have been nutrient-limited. Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 51-54 17220512-9 2007 The enzyme activity of glucose 6-phosphate dehydrogenase (G6PDH), the enzyme supporting the first step of the OPPP, was induced by external nitrate supply. Nitrates 140-147 glucose-6-phosphate dehydrogenase Homo sapiens 23-56 17172286-6 2007 Moreover, steady-state transcript levels were decreased after addition of ammonium or nitrate in N-deficient roots, suggesting a role for N availability in regulating AtAMT1;1 transcript abundance. Nitrates 86-93 ammonium transporter 1;1 Arabidopsis thaliana 167-175 16872740-6 2007 A concomitant removal of 97% of nitrate was observed for a mean influent concentration of 423.4 mg L-1. Nitrates 32-39 immunoglobulin kappa variable 1-16 Homo sapiens 99-102 17364893-3 2007 The activity and expression of eNOS, measured by nitrate levels and immunoblot, respectively, were determined following exposure of BRECs to varying concentrations of glucose and mannitol (0 to 25 mM). Nitrates 49-56 nitric oxide synthase 3 Bos taurus 31-35 17364893-4 2007 Under static conditions the expression of eNOS decreased significantly following exposure to increasing concentrations of glucose when compared to osmotic mannitol controls and was accompanied by a significant dose-dependent decrease in nitrate levels in conditioned medium. Nitrates 237-244 nitric oxide synthase 3 Bos taurus 42-46 18232232-4 2007 It restricted uptake and transport of NO3(-), inhibited activity of some key nitrogen-metabolism-related enzymes, such as: nitrate reductase (NR) to the nitrate reduction, glutamine systhetase (GS) and glutamine synthase (GOGAT) to the ammonia assimilation, while it increased the content of free amino acids and decreased that of soluble protein as well. Nitrates 123-130 inducible nitrate reductase [NADH] 1 Glycine max 142-144 17307929-6 2007 In seedlings grown under uninoculated conditions supplied with nitrate, nup85 did not arrest plant growth but significantly reduced seed production. Nitrates 63-70 NUP85 Lotus japonicus 72-77 17162569-4 2007 Comparison of the PAH degradation rates under three reducing conditions showed the following order: sulfate-reducing conditions > methanogenic conditions > nitrate-reducing conditions. Nitrates 162-169 phenylalanine hydroxylase Homo sapiens 18-21 17162569-6 2007 However, the addition of acetate, lactate or pyruvate inhibited PAH degradation under nitrate-reducing conditions. Nitrates 86-93 phenylalanine hydroxylase Homo sapiens 64-67 17470441-2 2007 Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes. Nitrates 51-58 nitrate reductase 1 Arabidopsis thaliana 68-85 17470441-2 2007 Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes. Nitrates 51-58 nitrate reductase 1 Arabidopsis thaliana 87-89 17470441-2 2007 Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes. Nitrates 68-75 nitrate reductase 1 Arabidopsis thaliana 87-89 17470441-3 2007 The use of an Arabidopsis NR-null mutant allowed the identification of genes that respond to nitrate when the production of downstream metabolites of nitrate is blocked. Nitrates 93-100 nitrate reductase 1 Arabidopsis thaliana 26-28 17470441-3 2007 The use of an Arabidopsis NR-null mutant allowed the identification of genes that respond to nitrate when the production of downstream metabolites of nitrate is blocked. Nitrates 150-157 nitrate reductase 1 Arabidopsis thaliana 26-28 17470441-6 2007 Most of these genes and pathways are ones that were identified using the NR-null mutant as responding directly to nitrate. Nitrates 114-121 nitrate reductase 1 Arabidopsis thaliana 73-75 17578866-7 2007 It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 30-38 17578866-7 2007 It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation. Nitrates 60-67 nitrate transporter 1.1 Arabidopsis thaliana 40-44 17578866-7 2007 It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation. Nitrates 60-67 AGAMOUS-like 44 Arabidopsis thaliana 101-105 17220512-9 2007 The enzyme activity of glucose 6-phosphate dehydrogenase (G6PDH), the enzyme supporting the first step of the OPPP, was induced by external nitrate supply. Nitrates 140-147 glucose-6-phosphate dehydrogenase Homo sapiens 58-63 17192887-7 2007 DMH-induced increases in the total nitrite/nitrate levels and the nitric oxide synthase (NOS) activity (n = 10-12, P < 0.05) were also reduced in the DMH + GM-CSF group (n = 8-9, P < 0.05). Nitrates 43-50 colony stimulating factor 2 Rattus norvegicus 159-165 17393066-1 2007 The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple sclerosis (MS) patients. Nitrates 188-195 S100 calcium binding protein B Homo sapiens 73-78 17109653-8 2006 prevented hypertension-induced attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for endothelial nitric oxide synthase (eNOS), serum nitrite/nitrate concentration and increase in expression of mRNA for p22phox, superoxide anion and serum TBARS. Nitrates 236-243 nitric oxide synthase 3 Rattus norvegicus 215-219 17085507-7 2007 Disruption of NRT2.2 in Atnrt2.2 reduced IHATS by 19% and this reduction was statistically significant only at 6 h after resupply of nitrate to nitrogen-deprived plants. Nitrates 133-140 nitrate transporter 2:1 Arabidopsis thaliana 14-18 17085507-7 2007 Disruption of NRT2.2 in Atnrt2.2 reduced IHATS by 19% and this reduction was statistically significant only at 6 h after resupply of nitrate to nitrogen-deprived plants. Nitrates 133-140 nitrate transporter 2:1 Arabidopsis thaliana 24-30 17148611-0 2006 The Arabidopsis NRT1.1 transporter participates in the signaling pathway triggering root colonization of nitrate-rich patches. Nitrates 105-112 nitrate transporter 1.1 Arabidopsis thaliana 16-20 16510147-9 2006 Interestingly, some medications taken by the patients (e.g. diuretics and short-acting nitrates) might affect plasma eotaxin levels. Nitrates 87-95 C-C motif chemokine ligand 11 Homo sapiens 117-124 17153996-2 2006 The higher content of NO3- in groundwater compared to surface water during both summer and winter seasons indicates that the karstic groundwater system cannot easily recover once contaminated with nitrate. Nitrates 197-204 NBL1, DAN family BMP antagonist Homo sapiens 22-25 17304849-1 2006 PBS, a new kind of biodegradable polymers (BDPs), can be used as carbon source and biofilm carrier to remove nitrate from drinking water source. Nitrates 109-116 translocator protein Homo sapiens 0-3 17304849-4 2006 Influent nitrate concentration (53 mg x L- 1) can be reduced to less than 10 mg x L(-1) within 12 h. The IR spectrum showed that under development of denitrifying biofilm, absorption band at 2 925 cm(-1),2 850 cm(-1), 3200 cm(-1) -3410 cm-1 became weak, which suggested that the content of methyl or hydroxyl group in PBS decreased slightly, and the other functional groups were not influenced apparently. Nitrates 9-16 translocator protein Homo sapiens 318-321 17153996-5 2006 Combined with information on NO3- /Cl-, the variations of the isotope values of nitrate in the groundwater show a mixing process of multiple sources of nitrate, especially in the summer season. Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 29-32 17092343-2 2006 According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the development of nitrate and cross-tolerance. Nitrates 99-106 aldehyde dehydrogenase 2, mitochondrial Mus musculus 166-172 17060777-11 2006 Conversely, urinary nitrate levels indicative of vascular e-NOS activity remained significantly and persistently higher in MP-treated animals (P < 0.05). Nitrates 20-27 nitric oxide synthase 3 Sus scrofa 58-63 17092343-2 2006 According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the development of nitrate and cross-tolerance. Nitrates 220-227 aldehyde dehydrogenase 2, mitochondrial Mus musculus 166-172 17345786-12 2006 Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate. Nitrates 81-88 angiogenin Rattus norvegicus 147-155 17132443-7 2006 Nitrate concentration, mg [N]/kg [dry soil], is estimated using the FT-IR/ATR spectrum of this second paste. Nitrates 0-7 ATR serine/threonine kinase Homo sapiens 68-77 17132443-2 2006 Several studies have shown that Fourier transform infrared attenuated total reflectance (FT-IR/ATR) spectroscopy could be used to estimate the nitrate content of standardized soil pastes. Nitrates 143-150 ATR serine/threonine kinase Homo sapiens 89-98 17132443-3 2006 Paste standardization appeared to be the main obstacle to in situ application of this approach, and the present study shows how FT-IR/ATR can be used to estimate both water content and nitrate concentration of field soil samples. Nitrates 185-192 ATR serine/threonine kinase Homo sapiens 128-137 17345786-12 2006 Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate. Nitrates 232-239 angiogenin Rattus norvegicus 147-155 16952382-8 2006 Moreover, hCG increased nitrate uptake into MLTC-1, which suggests the gonadotropin aids nitrite and nitrate ions in their steroidogenesis inhibitory activity. Nitrates 24-31 hypertrichosis 2 (generalised, congenital) Homo sapiens 10-13 17012411-9 2006 Plants resulting from a cross between both mutants (atnrt2.1-1 x atnar2.1-1) showed a phenotype like that of the atnar2.1-1 mutant when grown in 0.5 mm nitrate. Nitrates 152-159 nitrate transporter 2:1 Arabidopsis thaliana 52-60 16952382-8 2006 Moreover, hCG increased nitrate uptake into MLTC-1, which suggests the gonadotropin aids nitrite and nitrate ions in their steroidogenesis inhibitory activity. Nitrates 101-108 hypertrichosis 2 (generalised, congenital) Homo sapiens 10-13 16968407-5 2006 In this context, we hypothesize that IL-10, through its ability to inhibit anti-leishmanial macrophage activation, associated with the lower frequency of TNF-alpha(+) monocytes and ordinary levels of nitrite and nitrate are the major mechanisms associated with disease onset. Nitrates 212-219 interleukin 10 Homo sapiens 37-42 17043238-8 2006 Compared with wild-type microglia, mSOD1(G93A) microglia produced and released more superoxide and nitrite+nitrate, and induced more neuronal death. Nitrates 107-114 superoxide dismutase 1, soluble Mus musculus 35-40 16905358-2 2006 The first known member Nar1.1 encodes a chloroplast nitrite transporter that regulates nitrate assimilation according to carbon availability, and data supporting the idea that NAR1 proteins may participate in adjusting both nitrite and carbon utilization by Chlamydomonas cells are presented herein. Nitrates 87-94 NAR1.1 Chlamydomonas reinhardtii 23-29 17035137-5 2006 Individual nitrate exposures from beverages prepared with tap water were calculated by linking the postal code of individual residence at baseline to water company data. Nitrates 11-18 nuclear RNA export factor 1 Homo sapiens 58-61 16980702-3 2006 These results suggest that the replacement of Asp105 in AtNRT3.1 markedly reduces nitrate uptake and accumulation. Nitrates 82-89 nitrate transmembrane transporter Arabidopsis thaliana 56-64 17032626-7 2006 A positive correlation between NOx (nitrites and nitrates levels) and VEGF was found in healthy individuals (r = 0.55, p = 0.003), but there was no correlation in hypertensive patients. Nitrates 49-57 vascular endothelial growth factor A Homo sapiens 70-74 17000306-9 2006 The downregulated endothelial nitric oxide synthase level in the distended grafts was accompanied by a 45.2% +/- 3.1% reduction of phospho-endothelial nitric oxide synthase Ser1177 levels and by a significant reduction in nitric oxide synthase activity (12.1% +/- 1.2%) and nitrate production (48.9% +/- 5.6%) in comparison with that seen in drug-treated grafts. Nitrates 274-281 nitric oxide synthase 3 Homo sapiens 18-51 16905358-4 2006 The expression patterns for Nar1 transcripts showed differential responses to changes in nitrogen or carbon status, as well as a particular regulation by the nitrate assimilation regulatory gene Nit2. Nitrates 158-165 uncharacterized protein Chlamydomonas reinhardtii 195-199 17003285-2 2006 LPS decreased IGF-I mRNA in hepatocyte cultures and increased the nitrite + nitrate levels in the culture medium. Nitrates 76-83 interferon regulatory factor 6 Homo sapiens 0-3 16961492-1 2006 Because of the ubiquitous nature of anthropogenic nitrate (NO3(-)) in many parts of the world, determining background concentrations of NO3(-) in shallow ground water from natural sources is probably impossible in most environments. Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 59-62 18970764-7 2006 Nitrate was found being present at 4.79-5.99mug/mL in dew, 1.20-2.63mug/mL in rain, 0.32-0.60mug/mL in snow and 0.12-0.23mug/mL in lake water. Nitrates 0-7 Ras interacting protein 1 Homo sapiens 78-82 16412539-4 2006 The nitrate accumulation was 20-50mg NO3-N day(-1)kg(-1) observed after methylene urea fertilization of 889 g Nm(-2). Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 37-40 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrates 160-167 nitric oxide synthase 2 Homo sapiens 26-47 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrates 160-167 nitric oxide synthase 2 Homo sapiens 49-53 17003285-3 2006 Furthermore, there was a negative correlation between the IGF-I mRNA and the nitrite+nitrate levels. Nitrates 85-92 insulin like growth factor 1 Homo sapiens 58-63 17003285-6 2006 In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures. Nitrates 160-167 interferon regulatory factor 6 Homo sapiens 145-148 16434229-3 2006 Comparing with the calculated energies, it can be concluded that the syn conformers with Cs overall symmetry, a planar CC(O)ONO skeleton in nitrites, and a planar CC(O)ON skeleton in nitrates, respectively, are the most stable in the gas phase. Nitrates 183-191 synemin Homo sapiens 69-72 17003285-8 2006 However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. Nitrates 88-95 nitric oxide synthase 2 Homo sapiens 28-32 17003285-8 2006 However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression. Nitrates 88-95 interferon regulatory factor 6 Homo sapiens 73-76 16904722-11 2006 Nitro-group of PNP converted to nitrite and nitrate. Nitrates 44-51 purine nucleoside phosphorylase Homo sapiens 15-18 16906281-6 2006 Urinary nitrate (NO3) excretion was measured in 18 IDV-treated patients and compared with that of 8 patients treated with efavirenz, a drug without renal side effects. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 16600336-3 2006 The INCA-N model was able to simulate the seasonal and inter-annual variations in the stream-water nitrate concentrations, although the lowest concentrations during the growing season were not reproduced. Nitrates 99-106 caspase recruitment domain family member 17 Homo sapiens 4-8 16618496-8 2006 For the only two tributaries of the Thames which we have monitored for over 5 years (the Pang and the Kennet), nitrate concentrations have increased over time. Nitrates 111-118 contactin 3 Homo sapiens 89-93 16618496-10 2006 As the Pang and the Kennet river water is mainly supplied from the Chalk, the increasing nitrate concentrations over time clearly reflect increasing nitrate concentrations within the groundwater. Nitrates 89-96 contactin 3 Homo sapiens 7-11 16618496-10 2006 As the Pang and the Kennet river water is mainly supplied from the Chalk, the increasing nitrate concentrations over time clearly reflect increasing nitrate concentrations within the groundwater. Nitrates 149-156 contactin 3 Homo sapiens 7-11 16891913-0 2006 Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway. Nitrates 36-43 nitric oxide synthase 3, endothelial cell Mus musculus 72-79 16878138-0 2006 The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles. Nitrates 4-11 chloride channel A Arabidopsis thaliana 30-36 16878138-6 2006 We demonstrate that AtCLCa is able to accumulate specifically nitrate in the vacuole and behaves as a NO3-/H+ exchanger. Nitrates 62-69 chloride channel A Arabidopsis thaliana 20-26 16937444-7 2006 In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis. Nitrates 188-196 growth hormone 1 Homo sapiens 44-46 16937444-7 2006 In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis. Nitrates 188-196 growth hormone 1 Homo sapiens 137-139 16705756-4 2006 Nitrite plus nitrate levels were lower in iNOS(-/-) compared with iNOS(+/+) mice, but CCl(4) did not produce a significant effect in any mice. Nitrates 13-20 nitric oxide synthase 2, inducible Mus musculus 42-46 16777528-7 2006 Thus, in cucumber, NR and GS expression appear to be dominated by sugar levels, rather than by nitrate contents. Nitrates 95-102 nitrate reductase [NADH]-like Cucumis sativus 19-21 16683800-4 2006 According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water. Nitrates 157-164 secreted phosphoprotein 1 Homo sapiens 177-181 16929648-6 2006 The results suggest that methanogen, sulfate-reducing bacteria, and nitrate-reducing bacteria all are involved in the dechlorination of PCB congeners. Nitrates 68-75 pyruvate carboxylase Homo sapiens 136-139 16830541-5 2006 Under the hypotheses of no interaction and absence of mutual screening of radiation, nitrate would prevail over DOM as *OH source for a NO3-/DOM ratio higher than 3.3 x 10(-5) (mol NO3-) (mg C)(-1), DOM prevailing for lower values. Nitrates 85-92 NBL1, DAN family BMP antagonist Homo sapiens 136-139 16448661-1 2006 The adsorption of Co2+ ions from nitrate solutions using iron oxide nanoparticles of magnetite (Fe3O4) and maghemite (gamma-Fe2O3) has been studied. Nitrates 33-40 complement C2 Homo sapiens 18-21 16683800-4 2006 According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water. Nitrates 157-164 DNA polymerase iota Homo sapiens 219-223 16683800-4 2006 According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water. Nitrates 157-164 secreted phosphoprotein 1 Homo sapiens 229-233 16527817-0 2006 Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates. Nitrates 142-150 cytochrome p450 oxidoreductase Homo sapiens 37-62 16527817-1 2006 Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown. Nitrates 99-106 cytochrome p450 oxidoreductase Homo sapiens 10-35 16527817-1 2006 Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown. Nitrates 99-106 cytochrome p450 oxidoreductase Homo sapiens 37-40 16527817-1 2006 Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown. Nitrates 175-182 cytochrome p450 oxidoreductase Homo sapiens 10-35 16527817-1 2006 Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown. Nitrates 175-182 cytochrome p450 oxidoreductase Homo sapiens 37-40 16527817-3 2006 To characterize the mechanism of CPR-CP-mediated organic nitrate bioactivation, EPR, chemiluminescence NO analyzer, NO electrode, and immunoassay studies were performed. Nitrates 57-64 cytochrome p450 oxidoreductase Rattus norvegicus 33-36 16527817-4 2006 With rat hepatic microsomes or purified CPR, the presence of NADPH triggered organic nitrate reduction to NO2(-). Nitrates 85-92 cytochrome p450 oxidoreductase Rattus norvegicus 40-43 16527817-7 2006 Therefore, CPR catalyzes organic nitrate reduction, producing nitrite, whereas CP can mediate further nitrite reduction to NO. Nitrates 33-40 cytochrome p450 oxidoreductase Homo sapiens 11-14 16527817-8 2006 Nitrite-dependent NO generation contributed <10% of the CPR-CP-mediated NO generation from organic nitrates; thus, NO2(-) is not the main precursor of NO. Nitrates 102-110 cytochrome p450 oxidoreductase Rattus norvegicus 59-62 16527817-10 2006 Studies suggested that organic nitrite (R-O-NO) was produced from organic nitrate reduction by CPR. Nitrates 74-81 cytochrome p450 oxidoreductase Homo sapiens 95-98 16636306-5 2006 Treatment with two structurally dissimilar iNOS inhibitors at doses sufficient to decrease urine nitrate and/or nitrite exacerbated proteinuria. Nitrates 97-104 nitric oxide synthase 2 Rattus norvegicus 43-47 16719098-0 2006 Regional patterns in the isotopic composition of natural and anthropogenic nitrate in groundwater, High Plains, U.S.A. Mobilization of natural nitrate (NO3-) deposits in the subsoil by irrigation water in arid and semiarid regions has the potential to produce large groundwater NO3-concentrations. Nitrates 143-150 NBL1, DAN family BMP antagonist Homo sapiens 152-155 16424150-3 2006 The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria. Nitrates 4-11 glutathione S-transferase kappa 1 Homo sapiens 132-157 16632127-9 2006 A line of evidence including inhibitor studies, EPR spectroscopy, and nitrite/nitrate detection identifies catalase as a possible oxidant for the conversion of hydroxyurea to NO. Nitrates 78-85 catalase Rattus norvegicus 107-115 16634581-13 2006 The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens). Nitrates 111-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 49-55 16424150-7 2006 The cytosolic GST-mediated denitration of these organic nitrates in liver limits their interaction with other intracellular compartments to possible generation of NO and/or their subsequent availability and bioactivation in the systemic circulation and extrahepatic tissues. Nitrates 56-64 glutathione S-transferase kappa 1 Homo sapiens 14-17 16424150-3 2006 The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria. Nitrates 4-11 glutathione S-transferase kappa 1 Homo sapiens 159-162 16524873-5 2006 In nodules of Asppc plants, PEPC activity was reduced to about 10% of that of non-transformants and the plants showed typical nitrogen-deficient symptoms without a supply of nitrogen nutrient, and returned to normal growth when nitrate was supplied at 2.5 mM. Nitrates 228-235 LjPEPC1 Lotus japonicus 28-32 16609365-0 2006 A -786T>C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Nitrates 94-101 nitric oxide synthase 3 Homo sapiens 33-66 16680018-12 2006 The increase in plasma concentration of nitrate and nitrite was inhibited by BBS-2. Nitrates 40-47 Bardet-Biedl syndrome 2 protein Ovis aries 77-82 16543501-4 2006 Relative to data in control rats, arteries from Adv-CYP4A2-transduced rats produced more 20-HETE (129+/-10 versus 97+/-7 pmol/mg protein, P<0.01) and less nitric oxide (NO; 4.2+/-1.6 versus 8.4+/-1 nmol nitrite+nitrate/mg; P<0.05). Nitrates 214-221 cytochrome P450, family 4, subfamily a, polypeptide 2 Rattus norvegicus 52-58 16417494-4 2006 A total of 51 operons were directly or indirectly activated by NarL in response to nitrate; a further 41 operons were repressed. Nitrates 83-90 DNA-binding transcriptional dual regulator NarL Escherichia coli str. K-12 substr. MG1655 63-67 16545248-6 2006 The concentration of MPO was correlated with the concentrations of 8-isoprostane and nitrate, which were normalized to the nitrite concentration. Nitrates 85-92 myeloperoxidase Homo sapiens 21-24 16415212-0 2006 High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1. Nitrates 14-21 nitrate transmembrane transporter Arabidopsis thaliana 100-108 16415212-3 2006 AtNRT3.1 accounts for greater than 99% of NRT3 mRNA and is induced 6-fold by nitrate. Nitrates 77-84 nitrate transmembrane transporter Arabidopsis thaliana 0-8 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 0-7 nitrate transporter 1.1 Arabidopsis thaliana 51-59 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 0-7 nitrate transporter 2:1 Arabidopsis thaliana 64-72 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 0-7 nitrate transmembrane transporter Arabidopsis thaliana 88-96 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 25-32 nitrate transporter 1.1 Arabidopsis thaliana 51-59 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 25-32 nitrate transporter 2:1 Arabidopsis thaliana 64-72 16415212-6 2006 Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues. Nitrates 25-32 nitrate transmembrane transporter Arabidopsis thaliana 88-96 16415212-7 2006 Constitutive high-affinity influx was reduced by 34% and 89%, respectively, in Atnrt3.1-1 and Atnrt3.1-2 mutant plants, while high-affinity nitrate-inducible influx was reduced by 92% and 96%, respectively, following induction with 1 mm KNO(3) after 7 d of nitrogen deprivation. Nitrates 140-147 nitrate transmembrane transporter Arabidopsis thaliana 94-102 16471967-13 2006 In 11 (L10 and NO3-), the nitrate acts as a bidentate ligand and an [Ag-NO3-]infinity chain is formed. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 15-18 16471967-13 2006 In 11 (L10 and NO3-), the nitrate acts as a bidentate ligand and an [Ag-NO3-]infinity chain is formed. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 72-75 16673818-5 2006 When the initial nitrate concentration was 30.2 mg NO3- -N / L, the denitrification efficiency was 57.3% at an applied electric current of 15 mA and a hydraulic retention time (HRT) of 12 hours. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 51-54 16673818-7 2006 The nitrate removal rate of the reactor was 34.4 g NO3- -N/m3 x d, and the surface area loading was 1.34 g NO3- -N / m2 x d. CONCLUSION: The coated electrode may keep high quantity of biomass, thus achieving a high denitrification rate. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 51-54 16673818-7 2006 The nitrate removal rate of the reactor was 34.4 g NO3- -N/m3 x d, and the surface area loading was 1.34 g NO3- -N / m2 x d. CONCLUSION: The coated electrode may keep high quantity of biomass, thus achieving a high denitrification rate. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 107-110 16496123-10 2006 Both the reduction in plasma nitrate and nitrite and the elevation in aortic superoxide associated with STZ diabetes were normalised with VEGF treatment. Nitrates 29-36 vascular endothelial growth factor A Rattus norvegicus 138-142 16556209-9 2006 In an example application, we used all models to reanalyze a published PPT data set to obtain k estimates for nitrate consumption in a petroleum-contaminated aquifer. Nitrates 110-117 tachykinin precursor 1 Homo sapiens 71-74 16417494-6 2006 Global repression by the nitrate- and nitrite-responsive two-component system, NarQ-NarP, was shown for the first time. Nitrates 25-32 DNA-binding transcriptional dual regulator NarP Escherichia coli str. K-12 substr. MG1655 84-88 16523632-2 2006 The half-life of NO averages only 3 to 4 s in biological fluids, where it is rapidly converted to the stable oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 147-154 NBL1, DAN family BMP antagonist Homo sapiens 156-159 16495753-1 2006 The present study was designed to determine if endogenous calcitonin gene-related peptide (CGRP) affects the process of nitrate tolerance development in blood vessels. Nitrates 120-127 calcitonin-related polypeptide alpha Rattus norvegicus 91-95 16686191-1 2006 PBS, a new kind of biodegradable polymers (BDPs), was used as carbon source and biofilm carrier to remove nitrate from drinking water. Nitrates 106-113 cholinergic receptor muscarinic 3 Homo sapiens 0-3 16331442-5 2006 The TOX method is moderately sensitive to nitrate rinse volume. Nitrates 42-49 thymocyte selection associated high mobility group box Homo sapiens 4-7 16223957-5 2006 Inhibition of cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells after iNOS induction showed 40- to 100-fold higher IC(50) values than at the isolated enzyme, in agreement with the much higher l-arginine concentrations in cell culture media and inside intact cells. Nitrates 23-30 nitric oxide synthase 2 Homo sapiens 115-119 16391109-0 2006 Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1. Nitrates 56-63 nitrite extrusion protein 1 Pseudomonas aeruginosa PAO1 15-20 16391109-0 2006 Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1. Nitrates 56-63 nitrite extrusion protein 2 Pseudomonas aeruginosa PAO1 25-30 16391109-1 2006 Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa. Nitrates 168-175 nitrite extrusion protein 1 Pseudomonas aeruginosa PAO1 58-63 16391109-1 2006 Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa. Nitrates 168-175 nitrite extrusion protein 2 Pseudomonas aeruginosa PAO1 68-73 16739926-4 2006 It has very short life span and is converted into nitrites (NO2-) and nitrates (NO3-). Nitrates 70-78 NBL1, DAN family BMP antagonist Homo sapiens 80-83 16739926-6 2006 Prior determination of NO2-/NO3- the nitrates were reduced to nitrites with zinc, and total level of NO2- was detected by Griess reaction. Nitrates 37-45 NBL1, DAN family BMP antagonist Homo sapiens 28-31 16720601-8 2006 However, the vtc2 mutants produced greater numbers of longer LRs than wild-type or vtc1 plants at all levels of nitrate. Nitrates 112-119 GDP-L-galactose phosphorylase 1 Arabidopsis thaliana 13-17 16095667-8 2006 It was concluded that long-term exposure to high nitrate intake by drinking water and home made meals from local products results in increased thyroid volume and increased frequency of signs of subclinical thyroid disorders (thyroid hypoechogenicity by ultrasound, increased TSH level and positive anti-TPO). Nitrates 49-56 thyroid peroxidase Homo sapiens 303-306 16800771-10 2006 In vivo mechanistic studies with BRBs indicate that they reduce the growth rate of premalignant esophageal cells, in part, through down-regulation of cyclooxygenase-2 leading to reduced prostaglandin production and of inducible nitric oxide synthase leading to reduced nitrate/nitrite levels in the esophagus. Nitrates 269-276 prostaglandin-endoperoxide synthase 2 Homo sapiens 150-166 16532746-7 2006 The oxygen/nitrate return sludge model block predicts a 10% improvement of N removal performance under dynamic conditions, and might be the better modelling option for ASM1 plants: it is computationally more efficient and it will not overrate the importance of decay processes in the settler. Nitrates 11-18 H19 imprinted maternally expressed transcript Homo sapiens 168-172 16367968-5 2006 The seedling phenotype of vp10 mutants is consistent with disruptions in ABA and auxin biosynthesis, as well as a disruption in nitrate metabolism. Nitrates 128-135 viviparous10 Zea mays 26-30 16452058-11 2006 Fucoidin caused an increase in the fractional excretion of nitrates, a response accompanied by increased iNOS mRNA. Nitrates 59-67 nitric oxide synthase 2 Rattus norvegicus 105-109 23074496-6 2006 CONVENTIONAL APPROACHES TO RESTORING THE BALANCE BETWEEN OXYGEN SUPPLY AND DEMAND FOCUS ON THE DISRUPTION OF THE UNDERLYING DISEASE THROUGH: drug therapy (beta blockers, calcium channel blockers, nitrates, antiplatelet agents, ACE inhibitors, statins); life-style modifications (smoking cessation, weight loss); or revascularization techniques such as coronary artery bypass graft surgery (CABG) or percutaneous coronary interventions (PCI). Nitrates 196-204 angiotensin I converting enzyme Homo sapiens 227-230 16387564-1 2005 Phosphodiesterase 5 (PDE5) inhibitors have modest nitrate-like hemodynamic effects, lowering wedge pressure, pulmonary artery pressure, and systolic and diastolic arterial pressure. Nitrates 50-57 phosphodiesterase 5A Homo sapiens 0-19 16387564-1 2005 Phosphodiesterase 5 (PDE5) inhibitors have modest nitrate-like hemodynamic effects, lowering wedge pressure, pulmonary artery pressure, and systolic and diastolic arterial pressure. Nitrates 50-57 phosphodiesterase 5A Homo sapiens 21-25 16387566-5 2005 The duration of interaction between a PDE5 inhibitor and nitrate administration depends on the specific drug being studied. Nitrates 57-64 phosphodiesterase 5A Homo sapiens 38-42 16387572-6 2005 The emergency physician needs to have evidence-based guidance on how best to treat patients with potential ACS who are being treated for ED, how much time must elapse between the last dose of phosphodiesterase 5 (PDE5) inhibitor and treatment with nitrates, and how to modify treatment of patients with ACS when patients have recently used a PDE5 inhibitor. Nitrates 248-256 phosphodiesterase 5A Homo sapiens 342-346 16387572-7 2005 Additionally, patients who have been prescribed a PDE5 inhibitor should be educated on the use of nitrates and the need to inform physicians about the use of PDE5 inhibitors during all encounters so that risk can be minimized. Nitrates 98-106 phosphodiesterase 5A Homo sapiens 50-54 16235022-0 2005 The mobA gene is required for assimilatory and respiratory nitrate reduction but not xanthine dehydrogenase activity in Pseudomonas aeruginosa. Nitrates 59-66 MobA mobilisation protein Pseudomonas aeruginosa 4-8 16235022-4 2005 Regulation studies using a Phi(PA3030-lacZGm) reporter strain suggest that expression of mobA is not influenced by the type of nitrogen source or by anaerobiosis, whereas assimilatory nitrate reductase activity was detected only in the presence of nitrate. Nitrates 184-191 reductase Pseudomonas aeruginosa PAO1 192-201 16006543-6 2005 Nitrate/nitrite plasma levels of Hct-augmented hamsters increased relative to control and L-NAME treated animals. Nitrates 0-7 hair constriction Mus musculus 33-36 16199562-2 2005 Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite. Nitrates 206-213 napF Haemophilus influenzae Rd KW20 51-55 16269753-5 2005 Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature. Nitrates 398-405 transcription elongation factor A1 Homo sapiens 50-54 16307975-8 2005 Our results showed that diabetic rats were associated with increased 8-OHdG, IL-6, and ET-1 decreased [nitrate+nitrite]. Nitrates 103-110 endothelin 1 Rattus norvegicus 87-91 16214035-2 2005 Through a metabonomics approach termed "NObonomics," the effects of a prototypic NO donor (organic nitrate)-cyclooxygenase-2 inhibitor hybrid (NO-coxib), NMI-1093, on the NO metabolite status of the circulation and major organs have been profiled in vivo in the rat. Nitrates 99-106 prostaglandin-endoperoxide synthase 2 Homo sapiens 108-124 16262716-0 2005 Genetic analysis of Arabidopsis GATA transcription factor gene family reveals a nitrate-inducible member important for chlorophyll synthesis and glucose sensitivity. Nitrates 80-87 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 32-36 16262716-8 2005 A transcript profiling experiment revealed that a considerable proportion of genes downregulated in the loss-of-function mutants are involved in carbon metabolism and At5g56860 is thus designated GNC (GATA, nitrate-inducible, carbon metabolism-involved). Nitrates 207-214 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 196-199 16189417-6 2005 Furthermore, STAT-6 mice receiving DSS had dramatically higher levels of serum nitrite/nitrate than all other groups. Nitrates 87-94 signal transducer and activator of transcription 6 Mus musculus 13-19 16199562-2 2005 Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite. Nitrates 206-213 response regulator Haemophilus influenzae Rd KW20 154-158 16199562-8 2005 By contrast, expression from the H. influenzae napF-lacZ operon fusion in E. coli was stimulated equally well by nitrate in both narP and narL null mutants, indicating that phospho-NarL and -NarP are equally effective regulators of this promoter. Nitrates 113-120 napF Haemophilus influenzae Rd KW20 47-51 16157886-5 2005 NRT2.1 encodes a putative high-affinity nitrate transporter that functions at low external nitrate concentrations. Nitrates 40-47 nitrate transporter 2:1 Arabidopsis thaliana 0-4 16408766-7 2005 Recent studies indicate that the alternations of PKG expression and activity are closely related with the pathogenesis of atherosclerosis, restenosis, hypertension, hyperlipemia as well as nitrate tolerance. Nitrates 189-196 protein kinase cGMP-dependent 1 Homo sapiens 49-52 16156615-4 2005 IR and Raman analyses of 11a and 12a were performed to determine the coordination behavior of the nitrate counteranion, and it was found that both NO3- and H2O coordinate to the metal centers. Nitrates 98-105 NBL1, DAN family BMP antagonist Homo sapiens 147-150 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 phytosulfokine 1 precursor Arabidopsis thaliana 80-84 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 COP1-interacting protein 8 Arabidopsis thaliana 86-90 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 GRAS family transcription factor Arabidopsis thaliana 92-96 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 GRAS family transcription factor family protein Arabidopsis thaliana 176-180 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 NADPH-dependent thioredoxin reductase A Arabidopsis thaliana 206-210 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 sugar transporter 1 Arabidopsis thaliana 228-232 16212609-9 2005 A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites. Nitrates 197-204 sucrose synthase 1 Arabidopsis thaliana 234-238 16157886-8 2005 Furthermore, lateral root initiation is increased in lin1 relative to WT even when seedlings are grown on nitrate-free media, suggesting that the mutant phenotype is nitrate-independent. Nitrates 106-113 nitrate transporter 2:1 Arabidopsis thaliana 53-57 16157886-8 2005 Furthermore, lateral root initiation is increased in lin1 relative to WT even when seedlings are grown on nitrate-free media, suggesting that the mutant phenotype is nitrate-independent. Nitrates 166-173 nitrate transporter 2:1 Arabidopsis thaliana 53-57 16157886-10 2005 We propose that Arabidopsis NRT2.1 acts either as a nitrate sensor or signal transducer to coordinate the development of the root system with nutritional cues. Nitrates 52-59 nitrate transporter 2:1 Arabidopsis thaliana 28-32 16157886-6 2005 Direct measurement of nitrate uptake and nitrate content in the lin1 mutant seedlings established that both are indeed reduced. Nitrates 22-29 nitrate transporter 2:1 Arabidopsis thaliana 64-68 16157886-6 2005 Direct measurement of nitrate uptake and nitrate content in the lin1 mutant seedlings established that both are indeed reduced. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 64-68 16191399-5 2005 "Early entry" therapy with nitrates do not significantly improve survival in myocardial infarction but increases the beneficial effects of the ACE-inhibitor enalapril by 50%. Nitrates 27-35 angiotensin I converting enzyme Homo sapiens 143-146 15886273-10 2005 The protective effects of kallikrein were accompanied by increased urinary nitrate/nitrite and cGMP levels, and suppression of superoxide formation. Nitrates 75-82 kallikrein related peptidase 4 Homo sapiens 26-36 16139272-5 2005 These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway. Nitrates 32-40 angiotensinogen Rattus norvegicus 25-31 16139272-5 2005 These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway. Nitrates 32-40 mitogen activated protein kinase 3 Rattus norvegicus 55-61 16392746-0 2005 Regulation of glutamine synthetase and glutamate dehydrogenase in pea mutants rrrbrb, rrRbRb, and RRrbrb during nitrate nitrogen assimilation. Nitrates 112-119 glutamate-ammonia ligase Homo sapiens 14-34 16133968-10 2005 The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression. Nitrates 22-29 tumor necrosis factor Rattus norvegicus 72-81 16051882-3 2005 Recent animal data suggest that mitochondrial aldehyde dehydrogenase (ALDH2) plays a central role in nitrate bioactivation, but its role in humans is not known. Nitrates 101-108 aldehyde dehydrogenase 2 family member Homo sapiens 70-75 16133968-10 2005 The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression. Nitrates 22-29 nitric oxide synthase 2 Rattus norvegicus 92-96 16078689-1 2005 A fast and highly sensitive ion chromatographic method using monolithic ODS columns was developed for the determination of nitrite (NO2-) and nitrate (NO3-) in seawater. Nitrates 142-149 NBL1, DAN family BMP antagonist Homo sapiens 151-154 16148069-5 2005 We synthesized a novel organic nitrate [ethyl nitrate (ENO2)], tested it in vitro, and administered it to hypoxic piglets. Nitrates 31-38 enolase 2 Homo sapiens 55-59 15950430-4 2005 Low concentrations of TNFalpha caused luteolysis, which resulted in a decreased level of P4, and increased levels of PGF2alpha, LTC4 and nitrite/nitrate (stable metabolites of nitric oxide-NO) in the blood. Nitrates 145-152 tumor necrosis factor Bos taurus 22-30 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrates 135-143 nitric oxide synthase 3 Homo sapiens 77-110 16187580-4 2005 Results are reported here from a study designed to investigate the efficiency of deionized water extraction of aerosol nitrate (NO3-) and sulfate from nylon filters. Nitrates 119-126 NBL1, DAN family BMP antagonist Homo sapiens 128-131 16005970-1 2005 In recent years, nitrate (NO3) contamination of groundwater has become a growing concern for people in rural areas in North China Plain (NCP) where groundwater is used as drinking water. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 16007000-1 2005 OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations. Nitrates 135-143 nitric oxide synthase 3 Homo sapiens 112-116 15998848-7 2005 Rates of nitrate removal, determined from the ratio of NO3-N to Br and ground water flow, averaged 1.4 g N m(-3) of wall d(-1) and were markedly greater than denitrification rates determined using the acetylene block technique (average: 0.11 g N m(-3) of wall d(-1)). Nitrates 9-16 NBL1, DAN family BMP antagonist Homo sapiens 55-58 16180687-2 2005 The mean contents of nitrate were 0.73 +/- 14.57 mg/100 g, 0.61 +/- 1.12 mg/100 g and 0.25 +/- 0.33 mg/100 g as NO3-, respectively. Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 112-115 15998850-8 2005 Nitrate reduction by FeO was rapid and characterized by nearly stoichiometric conversion of NO3- to NH4+. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 92-95 15622524-5 2005 The appearance of iNOS expression correlates with increased levels of nitrite + nitrate levels and appearance of mitochondrial damage detected either at morphological and biochemical level. Nitrates 80-87 nitric oxide synthase 2 Rattus norvegicus 18-22 16013860-5 2005 The disposable sensor responds to nitrate rapidly-the typical response time is 5 min-and reversibly over a wide dynamic range (26 microM-63 mM) with sensor-to-sensor reproducibility (relative standard deviation, RSD, 3.68%, as log aNO3-, at the medium level of the range and RSD 1.39% for repeated measurements with the same sensor). Nitrates 34-41 anoctamin 3 Homo sapiens 231-235 16422846-0 2005 Successful withdrawal of oral long-acting nitrates to facilitate phosphodiesterase type 5 inhibitor use in stable coronary disease patients with erectile dysfunction. Nitrates 42-50 phosphodiesterase 5A Homo sapiens 65-89 16440845-6 2005 In nitrate treated animals, the weight of thyroid gland was increased significantly (P<0.001) while thyroid peroxidase activity (P<0.01), serum T4 (P<0.01) and serum T3 levels (P<0.001) were reduced; but serum TSH level was increased (P<0.001) along with slightly elevated iodine excretion level (P<0.001) in comparison to control animals. Nitrates 3-10 thyroid peroxidase Homo sapiens 103-121 16422846-2 2005 Phosphodiesterase type 5 (PDE5) inhibitors are effective in up to 80% of men but are contraindicated in the presence of oral nitrates, because of a potentially severe hypotensive interaction. Nitrates 125-133 phosphodiesterase 5A Homo sapiens 0-24 16422846-2 2005 Phosphodiesterase type 5 (PDE5) inhibitors are effective in up to 80% of men but are contraindicated in the presence of oral nitrates, because of a potentially severe hypotensive interaction. Nitrates 125-133 phosphodiesterase 5A Homo sapiens 26-30 16422846-5 2005 MAIN OUTCOME MEASURES: Discontinuation of oral nitrates to facilitate subsequent use of PDE5 therapy. Nitrates 47-55 phosphodiesterase 5A Homo sapiens 88-92 16422846-10 2005 Forty-nine of the 52 men no longer taking nitrates were treated with a PDE5 inhibitor which was effective in 22 out of 26 (85%) patients who have completed follow-up. Nitrates 42-50 phosphodiesterase 5A Homo sapiens 71-75 16422846-13 2005 CONCLUSION: Oral nitrates can be discontinued in the presence of continuing beta-blockade and/or calcium antagonist therapy in stable coronary disease patients with ED to allow for the safe use of PDE5 inhibitors. Nitrates 17-25 phosphodiesterase 5A Homo sapiens 197-201 15963975-3 2005 Coadministration of icatibant, a bradykinin B(2)-receptor antagonist (200 microg/kg/day), with enalapril blunted the stimulatory effect of the ACE inhibitor on eNOS mRNA expression, circulating levels of nitrite/nitrate, the relaxant activity of ACh and the release of 6-keto-PGF1alpha in L-NAME-treated rats. Nitrates 212-219 angiotensin I converting enzyme Rattus norvegicus 143-146 15847422-3 2005 When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1. Nitrates 170-177 NBL1, DAN family BMP antagonist Homo sapiens 8-11 22063496-4 2005 The effects of temperature, salt content, pH value and nitrate content on the activities of cathepsin B and L were evaluated using response surface methodology (RSM) and the actual activities of cathepsin B and L during Jinhua ham processing were calculated. Nitrates 55-62 cathepsin B Sus scrofa 92-103 15829709-5 2005 Total urinary nitrate and nitrite (NOx) excretion rates in UT-A1/3(-/-) mice were more than double those in wild-type mice. Nitrates 14-21 solute carrier family 14 (urea transporter), member 2 Mus musculus 59-64 15908593-0 2005 Light-dark changes in cytosolic nitrate pools depend on nitrate reductase activity in Arabidopsis leaf cells. Nitrates 32-39 nitrate reductase 1 Arabidopsis thaliana 56-73 15908593-8 2005 To study the role of assimilation, specifically the activity of NR in regulating the size of the cytosolic nitrate pool, we have compared wild-type and mutant plants. Nitrates 107-114 nitrate reductase 1 Arabidopsis thaliana 64-66 15908593-10 2005 Such changes were not observed in nia1nia2 NR-deficient plants indicating that this change in cytosolic nitrate activity was dependent on the presence of functional NR. Nitrates 104-111 nitrate reductase 1 Arabidopsis thaliana 165-167 15908593-12 2005 Epidermal cells of both wild type and NR mutants had cytosolic nitrate activities that were not significantly different from mesophyll cells in the dark and were unaltered by dark-to-light transitions. Nitrates 63-70 nitrate reductase 1 Arabidopsis thaliana 38-40 15908593-13 2005 We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate. Nitrates 54-61 nitrate reductase 1 Arabidopsis thaliana 20-22 15908593-13 2005 We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate. Nitrates 127-134 nitrate reductase 1 Arabidopsis thaliana 20-22 15908593-13 2005 We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate. Nitrates 127-134 nitrate reductase 1 Arabidopsis thaliana 20-22 15914972-12 2005 Both CsA and L-NAME reduced urinary nitrate excretion, which was reversed by co-administration of L-Arg. Nitrates 36-43 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 5-8 15847422-3 2005 When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1. Nitrates 170-177 NBL1, DAN family BMP antagonist Homo sapiens 131-134 15971422-2 2005 Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism. Nitrates 222-229 xanthine dehydrogenase Rattus norvegicus 143-166 15971422-2 2005 Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism. Nitrates 222-229 xanthine dehydrogenase Rattus norvegicus 168-171 15718929-7 2005 Similarly, L-NMMA given prophylactically, but not therapeutically, blocked TNF-alpha-induced increases in exhaled NO flow rates and plasma nitrite and nitrate concentrations (both P = 0.02). Nitrates 151-158 tumor necrosis factor Canis lupus familiaris 75-84 15808411-7 2005 Nitrite formed either by autooxidation of NO or by conversion of nitrate to nitrite by xanthine oxidase was converted into the powerful nitric dioxide radical by lactoperoxidase and H(2)O(2) that is derived from the metabolism of xanthine oxidase. Nitrates 65-72 lactoperoxidase Bos taurus 162-177 16229082-7 2005 Data show, moreover, that the Arabidopsis dual affinity nitrate transporter NRT1.1 (CHL1) may be involved in conveying the nitrate signal into seeds. Nitrates 56-63 nitrate transporter 1.1 Arabidopsis thaliana 76-82 16229082-7 2005 Data show, moreover, that the Arabidopsis dual affinity nitrate transporter NRT1.1 (CHL1) may be involved in conveying the nitrate signal into seeds. Nitrates 56-63 nitrate transporter 1.1 Arabidopsis thaliana 84-88 15507538-10 2005 Both GHRP-2 (10(-7) M) and ghrelin (10(-7) M) prevented endotoxin-induced IL-6 and decreased nitrite/nitrate release from peritoneal macrophages in vitro. Nitrates 101-108 ghrelin and obestatin prepropeptide Rattus norvegicus 27-34 15838044-5 2005 Like aerobic conditions, anaerobic derepression of TCA cycle enzymes in an ArcA mutant significantly increased the in vivo TCA flux when nitrate was present as an electron acceptor. Nitrates 137-144 arginine deiminase Escherichia coli 75-79 15820896-4 2005 Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center. Nitrates 219-226 secreted phosphoprotein 1 Homo sapiens 39-43 15788155-3 2005 Murine IFN-gamma-activated peritoneal exudate cells (PEC) produced nitric oxide (NO), measured as nitrite plus nitrate, and superoxide. Nitrates 111-118 interferon gamma Mus musculus 7-16 15742413-8 2005 Plasma ET-1 level in DU patients was higher than that of H pylori-negative and positive controls (3.59+/-0.96 vs 0.89+/-0.54 vs 0.3+/-0.2 pg/mL, P<0.01), while nitrate/nitrite levels among them were also significantly different (8.55+/-0.71 vs 5.27+/-0.68 vs 6.39+/-0.92 mumol/L, P<0.05). Nitrates 163-170 endothelin 1 Homo sapiens 7-11 16851295-5 2005 In contrast, with Y = NO3-, compounds such as CO or NO are formed during thermal treatment, indicating that nitrate ions burn the en ligands. Nitrates 108-115 NBL1, DAN family BMP antagonist Homo sapiens 22-25 15683794-4 2005 Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 251-254 15683794-4 2005 Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 344-347 15707054-1 2005 Nitrate (NO3) is one of the world"s major pollutants of drinking water resources. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 15693824-4 2005 Nitrate reduction varied between individuals (mean 85.4 +/- 15.9 nmol nitrite min(-1) with 10 ml 1 mm KNO(3) mouth wash) and was found to be concentrated at the rear of the tongue dorsal surface. Nitrates 0-7 CD59 molecule (CD59 blood group) Homo sapiens 78-84 15707067-1 2005 This study investigated the reaction mechanisms of nitrate (NO3-) with zerovalent iron (ZVI) media under conditions relevantto groundwatertreatment using permeable reactive barriers (PRB). Nitrates 51-58 NBL1, DAN family BMP antagonist Homo sapiens 60-63 16101430-1 2005 Organic nitrates, such as nitroglycerin, have been used in clinical practice for more than one century for the treatment of angina, even before the identification of Nitric Oxide (NO) as the so-called Endothelium Derived Relaxing Factor (EDRF). Nitrates 8-16 alpha hemoglobin stabilizing protein Homo sapiens 238-242 16161783-5 2005 In addition, the reaction of hydrocarbons with NO3 potentially has important implications for NOy speciation because a significant fraction of organic nitrates thus formed are sufficiently long-lived to leave the planetary boundary layer. Nitrates 151-159 NBL1, DAN family BMP antagonist Homo sapiens 47-50 21676740-8 2005 We propose hypotheses suggesting that nitrate could alter steroidogenesis by 1) conversion to nitrite and nitric oxide in the mitochondria, the site of initial steroid synthesis, 2) altering Cl(-) ion concentrations in the cell by substituting for Cl(-) in the membrane transport pump or 3) binding to the heme region of various P450 enzymes associated with steroidogenesis and altering enzymatic action. Nitrates 38-45 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 329-333 16459821-7 2005 Daily nitrate concentration as low as 1 mgN/L could be monitored in the effluent in some periods. Nitrates 6-13 helt bHLH transcription factor Homo sapiens 40-43 16187256-1 2005 Cell-free extracts of nitrate-grown Penicillium politans NRC-510 catalyzes the hydrolytic deamination of cytidine to uridine. Nitrates 22-29 nuclear receptor coactivator 6 Homo sapiens 57-60 15690230-7 2005 Nitrate (NO3) concentrations dropped immediately after plant incorporation, and then rose monotonically until the end of the experiments. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 15623798-8 2005 Phosphorylated eNOS (pp-eNOS) protein levels in BRECs were significantly increased from low to high flow in both mono- and cocultures, concomitant with a significant increase in nitrate levels in the conditioned medium after exposure to pulsatile flow. Nitrates 178-185 nitric oxide synthase 3 Bos taurus 15-19 15623798-8 2005 Phosphorylated eNOS (pp-eNOS) protein levels in BRECs were significantly increased from low to high flow in both mono- and cocultures, concomitant with a significant increase in nitrate levels in the conditioned medium after exposure to pulsatile flow. Nitrates 178-185 nitric oxide synthase 3 Bos taurus 24-28 15577225-6 2004 Pretreatment with protocatechuic acid isopropyl ester effectively suppressed the LPS/GalN-induced increase in plasma tumor necrosis factor (TNF)-alpha alanine aminotransferase (ALT), nitrite/nitrate levels, and hepatic malondialdehyde levels. Nitrates 191-198 toll-like receptor 4 Mus musculus 81-84 15498507-1 2004 It has been reported that macrophages produce substantial amounts of nitrite and nitrate after addition of catalase, but the mechanism associated remains unclear. Nitrates 81-88 catalase Mus musculus 107-115 15607619-6 2004 The level of plasma nitrite/nitrate was associated with the change in iNOS expression in SHR. Nitrates 28-35 nitric oxide synthase 2 Rattus norvegicus 70-74 15554929-8 2004 In contrast, PARP-1(-/-) mice exhibited a significant reduction of colon damage and apoptosis, which was associated with increased colonic expression of Bcl-2 and lower levels of plasma nitrate/nitrite when compared to wild-type mice. Nitrates 186-193 poly (ADP-ribose) polymerase family, member 1 Mus musculus 13-19 15475378-0 2004 Nitrate reductase regulation in tomato roots by exogenous nitrate: a possible role in tolerance to long-term root anoxia. Nitrates 58-65 nitrate reductase [NADH] Solanum lycopersicum 0-17 15452775-1 2004 The mechanism for the reaction between nitric oxide (NO) and O(2) bound to the heme iron of myoglobin (Mb), including the following isomerization to nitrate, has been investigated using hybrid density functional theory (B3LYP). Nitrates 149-156 myoglobin Homo sapiens 92-101 15567873-4 2004 METHODS: We used data from a multicentre, case-control study with maternal information on residential water source, and nitrate/nitrite levels of tap water measured by dipstick. Nitrates 120-127 nuclear RNA export factor 1 Homo sapiens 146-149 15475378-1 2004 The mechanism of nitrate reductase (NR) regulation under long-term anoxia in roots of whole plants and the putative role of nitrate in anoxia tolerance have been addressed. Nitrates 17-24 nitrate reductase [NADH] Solanum lycopersicum 36-38 15475378-5 2004 NR was slightly dephosphorylated in the absence of oxygen and nitrate. Nitrates 62-69 nitrate reductase [NADH] Solanum lycopersicum 0-2 15475378-6 2004 Under anoxia, NR dephosphorylation was modulated by nitrate-controlled NR activity. Nitrates 52-59 nitrate reductase [NADH] Solanum lycopersicum 14-16 15475378-6 2004 Under anoxia, NR dephosphorylation was modulated by nitrate-controlled NR activity. Nitrates 52-59 nitrate reductase [NADH] Solanum lycopersicum 71-73 15205115-4 2004 We investigated the effect of LPS on nitrate/nitrite and cytokine production in relation to the expression of inducible nitric oxide synthase, NTCP, BSEP, and MRP2 both at the level of mRNA with RT-PCR and protein using immunofluorescence microscopy. Nitrates 37-44 solute carrier family 10 member 1 Homo sapiens 143-147 15821986-0 2004 Ammonium transporter genes in Chlamydomonas: the nitrate-specific regulatory gene Nit2 is involved in Amt1;1 expression. Nitrates 49-56 nitrilase family member 2 Homo sapiens 82-86 15821986-10 2004 This second effect of nitrate was dependent on the functionality of the regulatory gene Nit2, specific for nitrate assimilation. Nitrates 22-29 nitrilase family member 2 Homo sapiens 88-92 15821986-10 2004 This second effect of nitrate was dependent on the functionality of the regulatory gene Nit2, specific for nitrate assimilation. Nitrates 107-114 nitrilase family member 2 Homo sapiens 88-92 15821986-11 2004 Thus, NIT2 would have a dual role on gene expression: the well-known positive one on nitrate assimilation and a novel negative one on Amt1;1 regulation. Nitrates 85-92 nitrilase family member 2 Homo sapiens 6-10 15465035-4 2004 We investigated the effect of the clinically used nitrates nitroglycerin (NTG), isosorbide dinitrate (ISDN), and sodium nitroprusside (SNP) on HIF-1-mediated transcriptional responses to hypoxia. Nitrates 50-58 hypoxia inducible factor 1 subunit alpha Homo sapiens 143-148 15465035-5 2004 We demonstrate that among the three nitrates, only SNP inhibits HIF-1 activation in response to hypoxia. Nitrates 36-44 hypoxia inducible factor 1 subunit alpha Homo sapiens 64-69 15331769-4 2004 Likewise, benomyl decreased GTN- and PETN-elicited phosphorylation of the cGMP-activated protein kinase substrate vasodilator-stimulated phosphoprotein (VASP) but not that elicited by other nitrates. Nitrates 190-198 vasodilator-stimulated phosphoprotein Rattus norvegicus 153-157 15331769-5 2004 The vasodilator potency of organic nitrates correlated with their potency to inhibit ALDH-2 dehydrogenase activity in mitochondria from rat heart and increase mitochondrial superoxide formation, as detected by chemiluminescence. Nitrates 35-43 aldehyde dehydrogenase 2 family member Rattus norvegicus 85-91 15331769-8 2004 We conclude that mitochondrial ALDH-2, specifically its esterase activity, is required for the bioactivation of the organic nitrates with high vasodilator potency, such as GTN and PETN, but not for the less potent nitrates. Nitrates 124-132 aldehyde dehydrogenase 2 family member Rattus norvegicus 31-37 15527785-4 2004 In cell homogenates, consumption of NO critically depended on the presence of NADPH or NADH and resulted in the formation of nitrate. Nitrates 125-132 2,4-dienoyl-CoA reductase 1 Homo sapiens 78-83 15454240-2 2004 The inhibition of the newly discovered cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isozyme XIII of murine origin (mCA XIII) has been investigated with a series of anions, such as the physiological ones (bicarbonate, chloride), or the metal complexing anions (cyanate, cyanide, azide, hydrogen sulfide, etc), nitrate, nitrite, sulfate, sulfamate, sulfamide as well as with phenylboronic and phenylarsonic acids. Nitrates 310-317 carbonic anhydrase 13 Mus musculus 116-124 15205115-4 2004 We investigated the effect of LPS on nitrate/nitrite and cytokine production in relation to the expression of inducible nitric oxide synthase, NTCP, BSEP, and MRP2 both at the level of mRNA with RT-PCR and protein using immunofluorescence microscopy. Nitrates 37-44 ATP binding cassette subfamily C member 2 Homo sapiens 159-163 15210285-7 2004 Well water in the region of Fez has moderately poor water quality with nitrate and metal enrichments. Nitrates 71-78 FEZ family zinc finger 1 Homo sapiens 28-31 15521966-7 2004 The serum concentrations of high density lipoprotein (HDL) cholesterol and nitrite/nitrate were significantly lower in the E4 group than in the E2 group (P < 0.05). Nitrates 83-90 ubiquitination factor E4A Homo sapiens 123-125 15717134-0 2004 Prevention of nitrate tolerance with angiotensin II receptor type 1 blocker in patients with stable angina: yet another failed strategy to prevent tolerance. Nitrates 14-21 angiotensin II receptor type 1 Homo sapiens 37-67 15570973-5 2004 The Co3O4 powders obtained by spraying nitrate solution at 500 degrees C show high specific surface area, which according to the BET method is 82.37 m2/g. Nitrates 39-46 delta/notch like EGF repeat containing Homo sapiens 129-132 15509836-0 2004 Mutation of a nitrate transporter, AtNRT1:4, results in a reduced petiole nitrate content and altered leaf development. Nitrates 14-21 nitrate transporter 1.1 Arabidopsis thaliana 35-43 15310822-0 2004 Quantitative trait loci analysis of nitrate storage in Arabidopsis leading to an investigation of the contribution of the anion channel gene, AtCLC-c, to variation in nitrate levels. Nitrates 167-174 chloride channel C Arabidopsis thaliana 142-149 15310822-13 2004 In wild-type plants, expression of AtCLC-c was down-regulated in the presence of nitrate, but ammonium had a much smaller effect while chloride and sulphate did not affect expression. Nitrates 81-88 chloride channel C Arabidopsis thaliana 35-42 15310822-14 2004 These and published results suggest that multiple genes affect nitrate concentrations in plants and that AtCLC-c and other members of the AtCLC gene family play some role in this. Nitrates 63-70 chloride channel C Arabidopsis thaliana 105-112 15509836-7 2004 This study revealed a critical role of AtNRT1:4 in regulating leaf nitrate homeostasis, and the deficiency of AtNRT1:4 can alter leaf development. Nitrates 67-74 nitrate transporter 1.1 Arabidopsis thaliana 39-47 15509836-2 2004 In the present study, characterization of the nitrate transporter, AtNRT1:4, revealed a special role of petiole in nitrate homeostasis. Nitrates 46-53 nitrate transporter 1.1 Arabidopsis thaliana 67-75 15294282-8 2004 The nitrate KM for S-NaR1 was 30 +/- 3 microM, which is very similar to YNaR1. Nitrates 4-11 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 21-25 15294282-2 2004 A simplified nitrate reductase (S-NaR1) consisting of Mo-MPT-binding site and nitrate-reducing active site was engineered from yeast Pichia angusta NaR cDNA (YNaR1). Nitrates 13-20 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 34-38 15294282-9 2004 S-NaR1 is capable of specific nitrate reduction, and direct electric current, as shown by catalytic nitrate reduction using protein film cyclic voltammetry, can drive this reaction. Nitrates 30-37 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 2-6 15294282-9 2004 S-NaR1 is capable of specific nitrate reduction, and direct electric current, as shown by catalytic nitrate reduction using protein film cyclic voltammetry, can drive this reaction. Nitrates 100-107 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 2-6 15294282-10 2004 Thus, S-NaR1 is an ideal form of this enzyme for commercial applications, such as an enzymatic nitrate biosensor formulated with S-NaR1 interfaced to an electrode system. Nitrates 95-102 iron-sulfur cluster assembly protein NAR1 Saccharomyces cerevisiae S288C 8-12 15333754-0 2004 Genomic analysis of the nitrate response using a nitrate reductase-null mutant of Arabidopsis. Nitrates 24-31 nitrate reductase 1 Arabidopsis thaliana 49-66 15333754-6 2004 Because the nitrate response of these genes was NR independent, nitrate and not a downstream metabolite served as the signal. Nitrates 12-19 nitrate reductase 1 Arabidopsis thaliana 48-50 15332144-9 2004 Residents with hypertension or diabetes mellitus, using nitrates or who were male were more likely to receive ACE inhibitors. Nitrates 56-64 angiotensin I converting enzyme Homo sapiens 110-113 15288585-0 2004 Aldehyde dehydrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. Nitrates 72-79 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 0-22 15288585-9 2004 The discrepancies are consistent with evidence that (a) organic nitrates, unlike chloral and cyanamide, irreversibly inactivate ALDH (hence reduced enzyme saturability can explain the biphasic curve) and (b) eNOS contributes to tolerance by a mechanism independent of glyceryl trinitrate metabolism. Nitrates 64-72 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 128-132 15332144-10 2004 Appropriate ACE inhibitor doses were associated with functional impairment, nitrate use and recent hospitalization. Nitrates 76-83 angiotensin I converting enzyme Homo sapiens 12-15 15107992-0 2004 Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2 restricts growth at low external nitrate concentration. Nitrates 18-25 nitrate transporter 2:1 Arabidopsis thaliana 44-52 15181112-5 2004 Very similar relationships were obtained for the steady-state levels of nii2 and nii4 mRNA in roots (2-4 x 10(5) and 8 x 10(6) copies microg(-1) of total RNA before and after nitrate treatment, respectively), and in leaves (5-9 x 10(4) and 4 x 10(5) copies microg(-1) of total RNA before and after nitrate treatment, respectively). Nitrates 298-305 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 72-76 15107992-0 2004 Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2 restricts growth at low external nitrate concentration. Nitrates 18-25 nitrate transporter 2:1 Arabidopsis thaliana 44-50 15276738-1 2004 A membrane bioreactor (MBR) was investigated for denitrification of nitrate (NO3(-)) contaminated drinking water. Nitrates 68-75 NBL1, DAN family BMP antagonist Homo sapiens 77-80 15356331-0 2004 AtIPT3 is a key determinant of nitrate-dependent cytokinin biosynthesis in Arabidopsis. Nitrates 31-38 isopentenyltransferase 3 Arabidopsis thaliana 0-6 15276755-7 2004 Nitrate concentration stabilized at about 6.3 mg NO3-N L(-1) for two weeks during alternating acetate pulse lengths. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 49-52 15166094-6 2004 Surprisingly, iNOS expression was not increased at 72 hours; instead, upregulation of neuronal NO synthase (nNOS) was evident at both the mRNA (+266+/-20%, P<0.005) and the protein levels (+195+/-66%, P<0.005), which was accompanied by an increase in myocardial nitrite/nitrate (+20+/-4%, P<0.05). Nitrates 276-283 nitric oxide synthase, brain Oryctolagus cuniculus 108-112 15123642-0 2004 Nitrate reductase activity is required for nitrate uptake into fungal but not plant cells. Nitrates 43-50 nitrate reductase 1 Arabidopsis thaliana 0-17 15123642-1 2004 The ability to transport net nitrate was conferred upon transformant cells of the non-nitrate-assimilating yeast Pichia pastoris after the introduction of two genes, one encoding nitrate reductase and the other nitrate transport. Nitrates 29-36 nitrate reductase 1 Arabidopsis thaliana 179-196 15123642-3 2004 In addition, loss-of-function nitrate reductase mutants isolated from several nitrate-assimilating fungi appeared to be unable to accumulate nitrate. Nitrates 78-85 nitrate reductase 1 Arabidopsis thaliana 30-47 15179450-10 2004 The finding of increased liver nitrite/nitrate content in NCX-1000-treated animals together with an increase in cGMP levels in their liver homogenates suggests that this nitro-compound behaves as a liver-selective NO donor. Nitrates 39-46 T cell leukemia homeobox 2 Homo sapiens 58-61 15123642-4 2004 Uptake assays using the tracer (13)NO(3)(-) showed that nitrate influx is negligible in cells of a nitrate reductase null mutant. Nitrates 56-63 nitrate reductase 1 Arabidopsis thaliana 99-116 15123642-5 2004 In parallel studies using a higher eukaryotic plant, Arabidopsis thaliana, loss-of-function nitrate reductase strains homozygous for both NIA1 insertion and NIA2 deletion were found to have no detectable nitrate reductase mRNA or nitrate reductase activity but retained the ability to transport nitrate. Nitrates 92-99 nitrate reductase 1 Arabidopsis thaliana 138-142 15123642-5 2004 In parallel studies using a higher eukaryotic plant, Arabidopsis thaliana, loss-of-function nitrate reductase strains homozygous for both NIA1 insertion and NIA2 deletion were found to have no detectable nitrate reductase mRNA or nitrate reductase activity but retained the ability to transport nitrate. Nitrates 92-99 nitrate reductase 2 Arabidopsis thaliana 157-161 15223851-3 2004 Both of these Pde-5 inhibitors have vasodilating properties and effects on blood pressure (BP), and like nitrates, they work through the nitric oxide cyclic guanosine monophosphate pathway. Nitrates 105-113 phosphodiesterase 5A Homo sapiens 14-19 15197447-8 2004 Without any exception it applies to all three PDE 5 inhibitors that they are absolutely contraindicated in patients taking nitrate- or molsidomine-containing medications and that they may interact in particular with non-uroselective alpha-adrenoceptor blockers. Nitrates 123-130 phosphodiesterase 5A Homo sapiens 46-51 15214777-4 2004 Chemiluminescence detection experiments show the ability of catalase to catalyze the formation of nitrite and nitrate from hydroxyurea. Nitrates 110-117 catalase Homo sapiens 60-68 15461259-5 2004 When the initial nitrate concentration was 30.7mg NO3- -N/L, the denitrification rate was 38.4% at an applied electric current of 10mA and a hydraulic retention time of 12 hours. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 50-53 15212692-0 2004 The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1. Nitrates 67-74 porin Shewanella oneidensis MR-1 27-32 15370692-7 2004 Intravenous infusion of human adrenomedullin induced a reduction of mean arterial pressure together with an increase of serum nitrate levels, which was abolished by neutralizing antibody against adrenomedullin. Nitrates 126-133 adrenomedullin Homo sapiens 30-44 15370692-7 2004 Intravenous infusion of human adrenomedullin induced a reduction of mean arterial pressure together with an increase of serum nitrate levels, which was abolished by neutralizing antibody against adrenomedullin. Nitrates 126-133 adrenomedullin Homo sapiens 195-209 15212692-6 2004 Although OMP35-1 grew on all electron acceptors tested, a significant lag was seen when grown on fumarate, nitrate, and Fe(III). Nitrates 107-114 porin Shewanella oneidensis MR-1 9-14 15212692-14 2004 Omp35 is required for normal rates of growth on Fe(III), fumarate, and nitrate, but its absence has no effect on the use of other electron acceptors. Nitrates 71-78 porin Shewanella oneidensis MR-1 0-5 15196936-1 2004 Dihydrolipoamide dehydrogenase (DLDH; EC 1.8.1.4) from porcine heart is capable of using nitric oxide (NO) as an electron acceptor, with NADH as the electron donor, forming nitrate in the reaction. Nitrates 173-180 dihydrolipoamide dehydrogenase Homo sapiens 0-30 15224139-11 2004 The results suggested that eNOS gene promoter activity was enhanced to 148.2+/-33.7% (P<0.05) of the control after PAECs were incubated with 10 micromol/L histamine for 24 h. The nitrite and nitrate content in culture media measured by colorimetric method after incubation with 10 micromol/L histamine for 24 h indicated that the NO production in PAECs was increased. Nitrates 194-201 nitric oxide synthase 3 Homo sapiens 27-31 15196936-1 2004 Dihydrolipoamide dehydrogenase (DLDH; EC 1.8.1.4) from porcine heart is capable of using nitric oxide (NO) as an electron acceptor, with NADH as the electron donor, forming nitrate in the reaction. Nitrates 173-180 dihydrolipoamide dehydrogenase Homo sapiens 32-36 15107452-7 2004 The complex regulation of nitrate reduction is likely to have evolved not only to optimize nitrogen assimilation, but also to prevent and control the formation of toxic, and possibly regulatory, products of NR activities. Nitrates 26-33 nitrate reductase 1 Arabidopsis thaliana 207-209 14963706-1 2004 Nitrate reductase (NR, EC 1.6.6.1) is a key regulatory enzyme in the assimilation of nitrate into amino acids in plant leaves. Nitrates 85-92 nitrate reductase [NADH] Solanum lycopersicum 0-17 15191513-7 2004 In these patients (inducible nitric oxide synthase-positive group), the serum level of gastrin was significantly higher than that of the inducible nitric oxide synthase-negative group (509.5 +/- 141.5 pg/mL vs. 210.0 +/- 227.2 pg/mL; P < 0.01), whereas there were no significant differences in serum levels of pepsinogen, anti-parietal cell antibody, and nitrate and nitrite or in scores of histological gastritis. Nitrates 358-365 gastrin Homo sapiens 87-94 15094329-9 2004 administration show a more pronounced and rapid NO delivery (peak of both NOx and RS-NO at 1 h and plateau between 1 and 2 h), still coincident with the peak of SA, and the presence in plasma of NCX 4015 (a metabolite of NCX 4016 which still bears the nitrate function). Nitrates 252-259 solute carrier family 8 member A1 Rattus norvegicus 195-198 15094329-9 2004 administration show a more pronounced and rapid NO delivery (peak of both NOx and RS-NO at 1 h and plateau between 1 and 2 h), still coincident with the peak of SA, and the presence in plasma of NCX 4015 (a metabolite of NCX 4016 which still bears the nitrate function). Nitrates 252-259 solute carrier family 8 member A1 Rattus norvegicus 221-224 14963706-1 2004 Nitrate reductase (NR, EC 1.6.6.1) is a key regulatory enzyme in the assimilation of nitrate into amino acids in plant leaves. Nitrates 85-92 nitrate reductase [NADH] Solanum lycopersicum 19-21 15155540-2 2004 In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point. Nitrates 169-176 myeloperoxidase Mus musculus 20-35 15080860-2 2004 Our previous studies suggested a relationship between cerebrospinal fluid (CSF) NO metabolites (nitrates and nitrites, NN(x)) and IGF-1 in patients with progressive encephalopathy, hypsarrhythmia and optic atrophy syndrome. Nitrates 96-104 insulin like growth factor 1 Homo sapiens 130-135 15088102-9 2004 Nitrite and nitrate release from hearts before (2.3 +/- 0.9 nmol/min/g) and after (2.4 +/- 1.9 nmol/min/g) 15 min treatment with erythropoietin (1.0 U/ml) were not different. Nitrates 12-19 erythropoietin Oryctolagus cuniculus 129-143 15155540-2 2004 In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point. Nitrates 169-176 myeloperoxidase Mus musculus 37-40 15224936-1 2004 In the context of agricultural nitrogen excesses in northwestern France, pyrite-bearing weathered schist aquifers represent important hydrological compartments due to their capacity to eliminate nitrate (NO3-). Nitrates 195-202 NBL1, DAN family BMP antagonist Homo sapiens 204-207 15135199-9 2004 Nitrate/nitrite level, glutamic oxalacetic transaminase (GOT) level and creatinine level were also significantly improved in AG+ANGII-treated rats compared to the other groups. Nitrates 0-7 angiotensinogen Rattus norvegicus 128-133 15050440-1 2004 The findings of various studies reporting temporal changes in CSF total nitrite/nitrate (NOx) levels after subarachnoid hemorrhage (SAH) vary considerably. Nitrates 80-87 colony stimulating factor 2 Homo sapiens 62-65 15115189-8 2004 The one major precaution for men taking PDE5 inhibitors is to avoid concomitant administration of therapeutic and recreational nitrate preparations. Nitrates 127-134 phosphodiesterase 5A Homo sapiens 40-44 15116844-1 2004 Increased nitrate (NO3) concentrations in streamwaters draining forested catchments are reportedly an early indicator of nitrogen (N) saturation. Nitrates 10-17 NBL1, DAN family BMP antagonist Homo sapiens 19-22 14665447-12 2004 Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group. Nitrates 92-99 nitric oxide synthase 3 Rattus norvegicus 15-30 15112822-1 2004 The isotopic composition of nitrate collected from aerosols, fog, and precipitation was measured and found to have a large 17O anomaly with delta17O values ranging from 20 percent per thousand to 30% percent per thousand (delta17O = delta17O - 0.52(delta18O)). Nitrates 28-35 zinc finger protein, FOG family member 1 Homo sapiens 61-64 15074615-12 2004 Taking into account the proximity of the sampling site to the sea, and the observed chloride depletion, coarse mode nitrate, during the non-Asian dust period, is assumed to originate from the reaction of nitric acid with sodium chloride on the surfaces of sea-salt particles although the chloride depletion was not shown to be large enough to prove this assumption. Nitrates 116-123 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 256-259 15041240-5 2004 The monomeric 8-coordinate complex [Bi(mtsc)2(NO3)], 4b, which was obtained by slow evaporation in MeOH of the 1.5 hydrates 4a, was depicted with one electron pair of the bismuth(III) atom, two deprotonated mtsc- ligand and one nitrate ion. Nitrates 228-235 NBL1, DAN family BMP antagonist Homo sapiens 46-49 15084732-3 2004 In plants, GATA DNA motifs have been implicated in light-dependent and nitrate-dependent control of transcription. Nitrates 71-78 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 11-15 15076233-0 2004 Development of insulin resistance by nitrate tolerance in conscious rabbits. Nitrates 37-44 insulin Oryctolagus cuniculus 15-22 16649597-4 2004 It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%. Nitrates 101-108 protein interacting with PRKCA 1 Homo sapiens 109-113 16649597-4 2004 It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%. Nitrates 101-108 protein interacting with PRKCA 1 Homo sapiens 109-113 16649597-4 2004 It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%. Nitrates 101-108 protein interacting with PRKCA 1 Homo sapiens 109-113 16649597-4 2004 It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%. Nitrates 101-108 protein interacting with PRKCA 1 Homo sapiens 109-113 14871307-11 2004 Nevertheless, our findings indicate the possibility that 14-3-3 binding to SnRK1-phosphorylated sites on NR and F2KP may regulate both nitrate assimilation and sucrose/starch partitioning in leaves. Nitrates 135-142 nitrate reductase 1 Arabidopsis thaliana 105-107 14871307-11 2004 Nevertheless, our findings indicate the possibility that 14-3-3 binding to SnRK1-phosphorylated sites on NR and F2KP may regulate both nitrate assimilation and sucrose/starch partitioning in leaves. Nitrates 135-142 fructose-2,6-bisphosphatase Arabidopsis thaliana 112-116 15076233-8 2004 We conclude that acutely nitrate patches improve insulin sensitivity whereas a 7-day chronic treatment schedule that results in hemodynamic nitrate tolerance also produces insulin resistance. Nitrates 25-32 insulin Oryctolagus cuniculus 49-56 14707155-7 2004 Acetylcholine (ACh)-induced relaxation of Phe contraction and vascular eNOS protein and nitrite/nitrate production were less in IL-6-infused than in control pregnant rats. Nitrates 96-103 interleukin 6 Rattus norvegicus 128-132 15228008-8 2004 Nitrate and light intensity positively regulate the gene transcription of NR, but ammonium ions and Glu, Gln do the negative way. Nitrates 0-7 inducible nitrate reductase [NADH] 1 Glycine max 74-76 14755345-9 2004 These observations suggest that nitrate tolerance is mediated, at least in significant part, by inhibition of vascular ALDH-2 and that mitochondrial ROS contribute to this inhibition. Nitrates 32-39 aldehyde dehydrogenase 2 family member Rattus norvegicus 119-125 14968431-0 2004 The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula polymorpha. Nitrates 20-27 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 12-16 14968347-19 2004 Thus, the ability to activate HO-1 induction and associated antioxidant pathways apparently distinguishes PETN from other long-acting nitrates and may explain their different patterns of action in vivo (Figure 9). Nitrates 134-142 heme oxygenase 1 Homo sapiens 30-34 15356719-6 2004 The crystal structure of Yb(L(4))(NO(3))(3) shows ytterbium in a 9-coordinate environment being bonded to three donor atoms of the ligand and three bidentate nitrate ions. Nitrates 158-165 ribosomal protein L4 Homo sapiens 28-32 14709911-3 2004 However, we recently identified PAP-I as a metabolic enzyme of an organic nitrate compound, RS-7897, which contains L-2-oxothiazolidine-4-carboxylic acid (L-OTCA). Nitrates 74-81 pyroglutamyl-peptidase I Rattus norvegicus 32-37 14968431-1 2004 Ynt1 is the only high-affinity nitrate uptake system in Hansenula polymorpha. Nitrates 31-38 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 0-4 14968431-2 2004 Nitrate uptake was directly correlated with the Ynt1 levels and shown to be independent of nitrate reductase (NR) activity levels. Nitrates 0-7 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 48-52 14968431-4 2004 Nitrite uptake in a wild-type strain was partially inhibited by nitrate to levels shown by a YNT1-disrupted strain in which, in turn, nitrite transport was not inhibited by nitrate. Nitrates 64-71 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 93-97 14968431-8 2004 At pH 5.5, the contribution of Ynt1 to high-affinity nitrate and nitrite uptake was around 95% and 60%, respectively. Nitrates 53-60 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 31-35 14968431-9 2004 The apparent Km of Ynt1 for nitrate and nitrite is in the microM range, as is the specific nitrite uptake system for nitrite. Nitrates 28-35 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 19-23 14968431-10 2004 The analysis of the effect of the reduced nitrogen sources on nitrate assimilation revealed that glutamine inactivates nitrate and nitrite transport, dependent on Ynt1, but not the nitrite-specific system. Nitrates 119-126 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 163-167 15537369-22 2004 The use of PDE5 inhibitors in the presence of oral nitrates is absolutely contraindicated. Nitrates 51-59 phosphodiesterase 5A Homo sapiens 11-15 15108630-1 2004 Nitrite (NO2-) and nitrate (NO3-) concentrations are usually measured as a marker of NO metabolism. Nitrates 19-26 NBL1, DAN family BMP antagonist Homo sapiens 28-31 15022606-1 2004 Nitrite (NO2) and nitrate (NO3) concentrations are usually measured as a marker of NO metabolism. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 15244341-4 2004 The OCN pellet slowly releases calcium and nitrate, together with ocher, into the sediment water interface, where all three components play an important role in reducing phosphate release from sediments. Nitrates 43-50 bone gamma-carboxyglutamate protein Homo sapiens 4-7 15199233-1 2004 Nitrite and nitrate are widely used reporters of endogenous nitric oxide (NO) and nitric oxide synthase (NOS) activity, which are crucial for a broad spectrum of physiological and pathophysiological pathways. Nitrates 12-19 nitric oxide synthase 2 Homo sapiens 82-103 15199238-1 2004 Measurement of the nitric oxide (NO) metabolites nitrite and nitrate in biological matrices is a reliable method to assess NO synthase (NOS) activity. Nitrates 61-68 nitric oxide synthase 2 Homo sapiens 123-134 14675438-7 2004 AtIPT3 was upregulated within 1 h after an application of nitrate to mineral-starved Arabidopsis plants. Nitrates 58-65 isopentenyltransferase 3 Arabidopsis thaliana 0-6 15588129-2 2004 In the presence of NADH or NADPH, diaphorase can convert selected NO donors, glycerol trinitrate (GTN) and formaldoxime (FAL) to nitrites and nitrates with NO as an intermediate. Nitrates 142-150 dihydrolipoamide dehydrogenase Homo sapiens 34-44 15032873-12 2004 Furthermore, the induction of glucose 6-phosphate dehydrogenase isoforms by ammonium and of ferredoxin and ferredoxin-NADP reductase by nitrate has been described. Nitrates 136-143 glucose-6-phosphate dehydrogenase Homo sapiens 30-63 15032873-12 2004 Furthermore, the induction of glucose 6-phosphate dehydrogenase isoforms by ammonium and of ferredoxin and ferredoxin-NADP reductase by nitrate has been described. Nitrates 136-143 ferredoxin reductase Homo sapiens 107-132 15230126-1 2004 AIM: To elucidate clinical implications of nitrates (NO3) concentration as an indicator of nitric oxide (NO) level in blood serum of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS). Nitrates 43-51 NBL1, DAN family BMP antagonist Homo sapiens 53-56 14643177-6 2004 Also, this dose of EGF diminished nitrate production significantly (P<0.01). Nitrates 34-41 epidermal growth factor like 1 Rattus norvegicus 19-22 15137421-3 2004 Generation of nitrogen gas (N2) and ammonium nitrogen (NH4-N) was simultaneously observed in the low load of nitrate (NO3-N) (below 0.68 g NO3-N/L). Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 118-121 14630420-1 2003 The average nitrate concentration in the groundwater of the Vitoria-Gasteiz (Basque Country) quaternary aquifer rose from 50 mg NO3-/l during 1986 to over 200 mg/l in 1995, which represents an increase of some 20 mg NO3-/l per year. Nitrates 12-19 NBL1, DAN family BMP antagonist Homo sapiens 128-131 14630420-1 2003 The average nitrate concentration in the groundwater of the Vitoria-Gasteiz (Basque Country) quaternary aquifer rose from 50 mg NO3-/l during 1986 to over 200 mg/l in 1995, which represents an increase of some 20 mg NO3-/l per year. Nitrates 12-19 NBL1, DAN family BMP antagonist Homo sapiens 216-219 14630420-11 2003 The mass of nitrate leached from the cultivated zone is five times higher than that of the nitrate leached from the uncultivated zone (1147 kg NO3-/ha in the cultivated sector as against 211 kg NO3-/ha in the uncultivated sector), although part of the nitrate leached into the soil had been previously deposited by the rise of the water table. Nitrates 12-19 NBL1, DAN family BMP antagonist Homo sapiens 143-146 14630420-11 2003 The mass of nitrate leached from the cultivated zone is five times higher than that of the nitrate leached from the uncultivated zone (1147 kg NO3-/ha in the cultivated sector as against 211 kg NO3-/ha in the uncultivated sector), although part of the nitrate leached into the soil had been previously deposited by the rise of the water table. Nitrates 12-19 NBL1, DAN family BMP antagonist Homo sapiens 194-197 14630420-12 2003 If we consider that the level of groundwater input is similar in both plots, we may conclude that 964 kg NO3-/ha circulated towards the groundwater in the cultivated zone during the period under study, representing 87% of the nitrate applied to the soil in the form of fertilizer during that period. Nitrates 226-233 NBL1, DAN family BMP antagonist Homo sapiens 105-108 15137421-3 2004 Generation of nitrogen gas (N2) and ammonium nitrogen (NH4-N) was simultaneously observed in the low load of nitrate (NO3-N) (below 0.68 g NO3-N/L). Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 139-142 14664604-1 2003 We have examined the photochemical reactions occurring after irradiation at 200 nm of the aqueous nitrate ion, NO3(-)(aq). Nitrates 98-105 NBL1, DAN family BMP antagonist Homo sapiens 111-114 12907425-7 2003 BBS-2 treatment blocked NOS2 dimerization and completely inhibited the endotoxin-induced increase of plasma nitrate and nitrite levels. Nitrates 108-115 Bardet-Biedl syndrome 2 (human) Mus musculus 0-5 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrates 215-222 nitric oxide synthase 2 Homo sapiens 28-32 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrates 215-222 myeloperoxidase Homo sapiens 47-50 14657339-8 2003 Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production. Nitrates 215-222 nitric oxide synthase 2 Homo sapiens 106-110 14636072-0 2003 Metmyoglobin and methemoglobin catalyze the isomerization of peroxynitrite to nitrate. Nitrates 78-85 hemoglobin subunit gamma 2 Homo sapiens 17-30 14622500-4 2003 PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain contraindicated in patients receiving organic nitrates. Nitrates 139-147 phosphodiesterase 5A Homo sapiens 0-5 12958042-8 2003 Nitrate levels markedly increased with ecSOD in injured artery homogenates (26+/-5 versus 4+/-0.3 micromol/L per mg, P=0.001). Nitrates 0-7 extracellular superoxide dismutase [Cu-Zn] Oryctolagus cuniculus 39-44 14606859-2 2003 The nitrate complexes (X = NO(3); M = Mn (1), Co (2), Ni (3), Cu (4)) crystallize isomorphously in monoclinic space group P2(1)/a. Nitrates 4-11 cyclin dependent kinase inhibitor 1A Homo sapiens 122-127 14642608-8 2003 Administration of NCX-1000 to BDL and sham operated rats resulted in a similar increase of nitrite/nitrate and cGMP concentrations in the liver. Nitrates 99-106 solute carrier family 8 member A1 Rattus norvegicus 18-21 14642695-0 2003 Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. Nitrates 69-76 prostaglandin I2 synthase Rattus norvegicus 44-65 14642699-1 2003 OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear. Nitrates 68-75 phosphodiesterase 5A Homo sapiens 106-125 14642699-1 2003 OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear. Nitrates 68-75 phosphodiesterase 5A Homo sapiens 127-131 14642699-1 2003 OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear. Nitrates 68-75 phosphodiesterase 5A Homo sapiens 196-200 14616932-0 2003 Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA). Nitrates 62-70 angiotensin I converting enzyme Homo sapiens 20-23 14568906-3 2003 In addition, tissue concentrations of nitrite and nitrate were significantly increased in rats transfected with the eNOS gene up to 2 weeks after transfection. Nitrates 50-57 nitric oxide synthase 3 Rattus norvegicus 116-120 14616932-2 2003 The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates. Nitrates 150-158 angiotensin I converting enzyme Homo sapiens 93-96 14616932-7 2003 Headache caused by nitrates was recorded in 12/762 (1.6%) ACE inhibitor users and in 24/775 (3.2%) other participants (P = 0.049). Nitrates 19-27 angiotensin I converting enzyme Homo sapiens 58-61 14616932-10 2003 In conclusion, this study suggests that among hypertensive subjects use of ACE inhibitors is associated with a reduced risk of headache caused by nitrates. Nitrates 146-154 angiotensin I converting enzyme Homo sapiens 75-78 14555283-7 2003 Nicorandil is able to inhibit TNFalpha release from lymphocytes, which requires the dual modes of both potassium channel opening and the nitrate moiety. Nitrates 137-144 tumor necrosis factor Homo sapiens 30-38 14573760-0 2003 Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance. Nitrates 48-55 aldehyde dehydrogenase 2 family member Rattus norvegicus 8-44 16736996-0 2003 [Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates. Nitrates 157-165 angiotensin I converting enzyme Homo sapiens 25-54 16736996-2 2003 Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates. Nitrates 241-249 angiotensin I converting enzyme Homo sapiens 24-53 14512447-1 2003 Nitrate tolerance (NT) in hypertension is attributed to reduced activity of soluble guanylyl cyclase (sGC). Nitrates 0-7 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 76-100 15011737-2 2003 An indirect form to detect NO production has been the quantification of its stable end products, nitrites and nitrates (NO2- + NO3-). Nitrates 110-118 NBL1, DAN family BMP antagonist Homo sapiens 127-130 14520629-3 2003 Recently, a gene polymorphism of the endothelial NO synthase (ENOS) gene was identified that is associated with circulating nitrate levels. Nitrates 124-131 nitric oxide synthase 3 Homo sapiens 62-66 13679077-6 2003 We demonstrate that peroxynitrite and myeloperoxidase nitrate xanthine in vitro. Nitrates 54-61 myeloperoxidase Homo sapiens 38-53 14512447-1 2003 Nitrate tolerance (NT) in hypertension is attributed to reduced activity of soluble guanylyl cyclase (sGC). Nitrates 0-7 guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus 102-105 12892664-5 2003 Moreover, the high sulfate and nitrate conversion values (SOR and NOR) presented herein suggest that secondary formations from SO2 to SO4(2-) and from NO2 to NO3- are present in significant quantities in the atmosphere of southern Taiwan on episode days. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 158-161 14692506-4 2003 Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison. Nitrates 141-148 carbonic anhydrase 1 Homo sapiens 42-46 12974902-4 2003 The current study was undertaken to evaluate the relationship between plasma EPO levels and the severity of liver disease, hemodynamic values, renal functions, and plasma nitrate/nitrite levels in patients with cirrhosis. Nitrates 171-178 erythropoietin Homo sapiens 77-80 14692506-4 2003 Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison. Nitrates 141-148 carbonic anhydrase 2 Homo sapiens 51-56 14581628-4 2003 Transcripts of Ntdin are induced by sulfate or nitrate but not by phosphate, suggesting its involvement in sulfur and nitrogen metabolism. Nitrates 47-54 thiosulfate sulfurtransferase 16, chloroplastic-like Nicotiana tabacum 15-20 14499528-5 2003 Over a period exceeding 100 years mean nitrate concentrations increased from 1.04 mg NO3-Nl(-1) to 6.37 mg NO3-Nl(-1). Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 85-88 14499528-5 2003 Over a period exceeding 100 years mean nitrate concentrations increased from 1.04 mg NO3-Nl(-1) to 6.37 mg NO3-Nl(-1). Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 107-110 14499528-7 2003 Nitrate data throughout this early period reflect natural background concentrations of approximately 1 mg NO3-Nl(-1). Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 106-109 14512099-3 2003 In SHR, the NCX 4016 treatment increased the serum nitrite/nitrate and diminished the serum thromboxane B2, whereas aspirin did not change blood pressure but abolished the serum thromboxane B2. Nitrates 59-66 solute carrier family 8 member A1 Rattus norvegicus 12-15 12952843-0 2003 Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina. Nitrates 15-22 angiotensinogen Homo sapiens 60-74 12952843-11 2003 These results suggest that increased oxidative stress induced by activation of angiotensin II may play an important role in the development of nitrate tolerance. Nitrates 143-150 angiotensinogen Homo sapiens 79-93 14611844-3 2003 Inhibition data of the cytosolic isozymes CA I and CA II as well as the membrane-bound isozyme CA IV with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, sulfamate, and sulfamidate and so on, are also provided for comparison. Nitrates 185-192 carbonic anhydrase 4 Homo sapiens 95-100 12927686-0 2003 Comparison of cadmium and enzyme-catalyzed nitrate reduction for determination of NO2-/NO3- in breath condensate. Nitrates 43-50 NBL1, DAN family BMP antagonist Homo sapiens 87-90 12950342-1 2003 Nitric oxide (NO) is a free radical synthesized from l-arginine by a family of NO synthase (NOS) enzymes, all of which are present in the skin, and also by reduction of sweat nitrate. Nitrates 175-182 nitric oxide synthase 1, neuronal Mus musculus 79-90 14756320-9 2003 The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation. Nitrates 72-79 transcription factor MYB101 Glycine max 112-118 14692450-9 2003 stressed two Michaelis-Menten (MM) mechanisms to mediate the observed nitrate-induced currents, I(NO3-). Nitrates 70-77 NBL1, DAN family BMP antagonist S homeolog Xenopus laevis 98-101 15969098-0 2003 [Induced activity of nitrate reductase by nitrate and cloning of nitrate reductase gene]. Nitrates 21-28 nitrate reductase [NADH] Solanum lycopersicum 65-82 15969098-3 2003 Enhancing the activity of NR is conducive to reduce the concentration of nitrate in plants. Nitrates 73-80 nitrate reductase [NADH] Solanum lycopersicum 26-28 15969098-16 2003 According to these results, the level of NR mRNA in plants could be enhanced by nitrate inducement. Nitrates 80-87 nitrate reductase [NADH] Solanum lycopersicum 41-43 14756320-9 2003 The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation. Nitrates 72-79 transcription factor MYB101 Glycine max 214-220 14756320-9 2003 The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation. Nitrates 276-283 transcription factor MYB101 Glycine max 112-118 14756320-9 2003 The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation. Nitrates 276-283 chalcone synthase 3 Glycine max 147-150 12869520-0 2003 Induction of nitrate uptake in maize roots: expression of a putative high-affinity nitrate transporter and plasma membrane H+-ATPase isoforms. Nitrates 13-20 membrane H(+)-ATPase 1 Zea mays 107-132 12899636-1 2003 The tetraheme c-type cytochrome, CymA, from Shewanella oneidensis MR-1 has previously been shown to be required for respiration with Fe(III), nitrate, and fumarate [Myers, C. R., and Myers, J. M. (1997) J. Bacteriol. Nitrates 142-149 cytochrome c Shewanella oneidensis MR-1 33-37 12869520-7 2003 Both genes, classified as members of the PM H+-ATPase subfamily II, responded to nitrate supply, although to different degrees: MHA4, in particular, proved more sensitive than MHA3, with a greater up- and down-regulation in response to the treatment. Nitrates 81-88 proton-exporting ATPase 4 Zea mays 128-132 12871833-12 2003 However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue. Nitrates 23-30 nitric oxide synthase 2 Rattus norvegicus 153-184 12834739-7 2003 This observation suggested that in addition to the two well-accepted groups of phosphorus removal bacteria (one can only utilize oxygen to take up phosphorus, P(O), while the other can use both oxygen and nitrate, P(ON)), a new group of phosphorus removal bacteria, P(ON(n)), which could use oxygen, nitrate or nitrite to take up phosphorus was identified. Nitrates 300-307 paraoxonase 1 Homo sapiens 214-219 12754263-11 2003 These results demonstrate that (i) exogenously supplied glucose can replace the function of photoassimilates in roots; (ii) APR is subject to co-ordinated metabolic control by carbon metabolism; (iii) positive sugar signalling overrides negative signalling from nitrate assimilation in APR regulation. Nitrates 262-269 APS reductase 1 Arabidopsis thaliana 124-127 12871833-12 2003 However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue. Nitrates 23-30 nitric oxide synthase 2 Rattus norvegicus 186-190 12871833-12 2003 However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue. Nitrates 23-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 196-212 12871833-12 2003 However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue. Nitrates 23-30 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 214-219 12690103-1 2003 A significant increase in the induction of inducible nitric-oxide synthase (iNOS) protein expression and in the levels of nitrite plus nitrate was observed in rat aortic smooth muscle cells (RASMCs) stably transfected with catalase (RASMC-2C2) as compared with empty vector-transfected RASMC-V4 cells after exposure to cytokines and lipopolysaccharide. Nitrates 135-142 catalase Rattus norvegicus 223-231 12804571-8 2003 The effects of formate on ATPase activity disappeared when cells were performing anaerobic (nitrate/nitrite) or aerobic respiration. Nitrates 92-99 ATPase Escherichia coli 26-32 12805587-1 2003 The genomic response to low levels of nitrate was studied in Arabidopsis using the Affymetrix ATH1 chip containing more than 22,500 probe sets. Nitrates 38-45 homeobox protein ATH1 Arabidopsis thaliana 94-98 12892378-6 2003 Concomitantly, plasma NO products (nitrate + nitrite), which increased 2.2-fold during Mg-deficiency, were completely suppressed by the SPR blockade. Nitrates 35-42 sepiapterin reductase Rattus norvegicus 136-139 12956537-5 2003 Experiments with various nitrogen supply regimes demonstrated the induction of NRT2.1 expression by nitrate and repression by amino acids. Nitrates 100-107 nitrate transporter 2:1 Arabidopsis thaliana 79-83 12956537-0 2003 Regulation of the nitrate transporter gene AtNRT2.1 in Arabidopsis thaliana: responses to nitrate, amino acids and developmental stage. Nitrates 18-25 nitrate transporter 2:1 Arabidopsis thaliana 43-51 12956537-7 2003 Taken together, our results support the hypothesis that the NRT2.1 gene codes for a major component of the inducible high-affinity transport system for nitrate, which is spatially and developmentally controlled at the transcriptional level. Nitrates 152-159 nitrate transporter 2:1 Arabidopsis thaliana 60-66 12809317-1 2003 Denitrification, the anaerobic microbial conversion of nitrate (NO3-) to nitrogen (N) gases, is an important process contributing to the ability of riparian zones to function as "sinks" for NO3- in watersheds. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 64-67 12809317-1 2003 Denitrification, the anaerobic microbial conversion of nitrate (NO3-) to nitrogen (N) gases, is an important process contributing to the ability of riparian zones to function as "sinks" for NO3- in watersheds. Nitrates 55-62 NBL1, DAN family BMP antagonist Homo sapiens 190-193 12686872-10 2003 This change in erectile function was a result of eNOS over expression with an increase in eNOS protein expression and constitutive NOS activity as well as an increase in nitric oxide biosynthesis, as reflected by an increase in cavernous nitrate plus nitrite formation. Nitrates 238-245 nitric oxide synthase 3 Rattus norvegicus 49-53 14659339-7 2003 In the metastatic disease group, there was a positive correlation between serum VEGF levels and nitrate+nitrite levels (r=0.436, P<0.05). Nitrates 96-103 vascular endothelial growth factor A Homo sapiens 80-84 12654474-5 2003 In contrast, chemiluminescence analysis, which detects NO, NO2-, and nitrate (NO3-) (collectively referred to as NO(x)), detected significant increases in NO(x) from stimulated PAEC. Nitrates 69-76 NBL1, DAN family BMP antagonist Homo sapiens 78-81 12806280-1 2003 Activated monocytes-macrophages may be associated with antitumor activity, and activation of these cells by certain cytokines, primarily interferon gamma (IFN-gamma), can be indicated by alterations in the concentrations of neopterin, nitrate, or tryptophan. Nitrates 235-242 interferon gamma Homo sapiens 137-164 15270349-4 2003 Further, it was also found during study that, 16.00% of the borewell samples analyzed, were found to contain more than 100.00 PPM of nitrates (measured as NO3 mg/L, safe limit prescribed by BIS). Nitrates 133-141 NBL1, DAN family BMP antagonist Homo sapiens 155-158 12756917-8 2003 Nitrate reductase activity in bacteroids along nodule growth decreased in all groups including the ineffective AN group, whose nodulation was highly inhibited by nitrate at 5 mmol/L N. Host-cultivar interaction seemed to influence the regulation of nitrate reductase activity in bacteroids. Nitrates 162-169 inducible nitrate reductase [NADH] 1 Glycine max 0-17 12708697-4 2003 A nitrate plume in shallow ground water with concentrations exceeding 10 mg NO3-N L(-1) moved into the restored forested riparian wetland. Nitrates 2-9 NBL1, DAN family BMP antagonist Homo sapiens 76-79 12615686-8 2003 Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin. Nitrates 127-134 glucose-6-phosphate dehydrogenase Bos taurus 18-22 12615686-8 2003 Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin. Nitrates 127-134 kininogen 1 Bos taurus 204-214 12646747-6 2003 Intravitreal ET-1 significantly elevated the levels of nitrate to 189% of baseline 10 min after ET-1 application, which was inhibited by pretreatment of intravenous L-NAME (50 mg/kg). Nitrates 55-62 endothelin-1 Oryctolagus cuniculus 13-17 12584267-10 2003 Correspondingly, urinary nitrate/nitrite excretion was significantly elevated in ET-1 transgenic mice. Nitrates 25-32 endothelin 1 Mus musculus 81-85 12646747-6 2003 Intravitreal ET-1 significantly elevated the levels of nitrate to 189% of baseline 10 min after ET-1 application, which was inhibited by pretreatment of intravenous L-NAME (50 mg/kg). Nitrates 55-62 endothelin-1 Oryctolagus cuniculus 96-100 12644691-6 2003 In contrast, the Aox1 expression is strongly dependent on the nitrogen source, being down-regulated by ammonium and stimulated by nitrate. Nitrates 130-137 uncharacterized protein Chlamydomonas reinhardtii 17-21 12668777-0 2003 Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision. Nitrates 80-87 nitrate transporter 1.1 Arabidopsis thaliana 14-18 12668777-0 2003 Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision. Nitrates 80-87 nitrate transporter 2:1 Arabidopsis thaliana 23-27 12668777-6 2003 Expression of AtNRT2.5, one of the nitrate-repressible genes, was strongly suppressed by nitrate provision in both roots and shoots. Nitrates 35-42 nitrate transporter2.5 Arabidopsis thaliana 14-22 12668777-6 2003 Expression of AtNRT2.5, one of the nitrate-repressible genes, was strongly suppressed by nitrate provision in both roots and shoots. Nitrates 89-96 nitrate transporter2.5 Arabidopsis thaliana 14-22 12644691-8 2003 The stimulation by nitrate also occurs at the AOX protein and respiratory levels. Nitrates 19-26 uncharacterized protein Chlamydomonas reinhardtii 46-49 12644691-10 2003 The observed pattern of AOX regulation points to the possible interaction between chloroplast and mitochondria in relation to a potential increase of photogenerated ATP when nitrate is used as a nitrogen source. Nitrates 174-181 uncharacterized protein Chlamydomonas reinhardtii 24-27 12549937-10 2003 Thus, XOR catalyzed nitrate reduction to nitrite and NO occurs and can be an important source of NO production in ischemic tissues. Nitrates 20-27 xanthine dehydrogenase Homo sapiens 6-9 15055718-9 2003 On the other hand, long-term treatment with this AT1 receptor antagonist produced a significant increase of nitrate/nitrite and cGMP plasma levels. Nitrates 108-115 angiotensin II receptor, type 1a Rattus norvegicus 49-52 12527339-6 2003 resulted in a significant reduction of the expression of iNOS protein in rat lung tissue and in the plasma nitrite/nitrate (NOx) level. Nitrates 115-122 nitric oxide synthase 2 Rattus norvegicus 57-61 12563676-10 2003 The serum nitrite/nitrate levels, histological grades of articular cartilage degradation, and numbers of apoptotic chondrocytes and nitrotyrosine positive chondrocytes were significantly lower in NOS2-/- mice with AMA than in WT mice with AMA. Nitrates 18-25 nitric oxide synthase 2, inducible Mus musculus 196-200 12500206-7 2003 Among ascitic patients, those with high LBP showed greater (P <.05) levels of sCD14, tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), nitrites + nitrates (NOx)/creatinine, and renin, and lower vascular resistance. Nitrates 162-170 lipopolysaccharide binding protein Homo sapiens 40-43 12693036-4 2003 We find that peroxynitrite selectively nitrates Tyr99 at physiological pH, resulting in the formation of between 0.05 and 0.25 mol of nitrotyrosine/mol of CaM when the added molar ratio of peroxynitrite per CaM was varied between 2.5 and 1.5. Nitrates 39-47 calmodulin 1 Homo sapiens 155-158 12653221-4 2003 Water-immersion-restraint stress (WIRS) increased myeloperoxidase (MPO) activity in gastric mucosa and induced hemorrhagic erosions by a nitrate-inhibitable mechanism. Nitrates 137-144 myeloperoxidase Rattus norvegicus 67-70 12647538-2 2003 Mercury iodide and nitrate contribute more to inhibiting cathepsin B and calpains activities in the above tissues, respectively. Nitrates 19-26 cathepsin B Rattus norvegicus 57-68 12602959-5 2003 NO is an extremely unstable molecule and rapidly converted in vivo and in vitro to nitrate (NO3-) and nitrite (NO2-). Nitrates 83-90 NBL1, DAN family BMP antagonist Homo sapiens 92-95 12509525-7 2003 At the cellular level, chl1 mutants showed reduced nitrate accumulation in guard cells during stomatal opening and failed to show nitrate-induced depolarization of guard cells. Nitrates 51-58 cell adhesion molecule L1 like Homo sapiens 23-27 12685047-2 2003 In maize, a C4 plant, expression of genes for the non-photosynthetic isoproteins, Fd VI and R-FNR, is responsive to nitrate in roots whereas the expression and the spatial distribution in the leaves have not been analysed. Nitrates 116-123 ferredoxin-6, chloroplastic Zea mays 82-87 12685047-4 2003 Upon addition of nitrate, the transcripts for Fd VI and R-FNR rapidly accumulated in the leaves, whereas light did not induce accumulation. Nitrates 17-24 ferredoxin-6, chloroplastic Zea mays 46-51 12685047-6 2003 In the leaf, the transcripts for Fd VI and R-FNR were predominantly detected in mesophyll cells as were those for nitrate-assimilatory enzymes. Nitrates 114-121 ferredoxin-6, chloroplastic Zea mays 33-38 12906266-3 2003 Results of the study showed various heterotrophic bacteria to be capable of anoxic P accumulation utilising nitrate (NO3) as electron acceptor. Nitrates 108-115 NBL1, DAN family BMP antagonist Homo sapiens 117-120 12906301-6 2003 Anaerobic H2S oxidation with NO3- was also induced by addition of nitrate to the medium. Nitrates 66-73 NBL1, DAN family BMP antagonist Homo sapiens 29-32 14682566-3 2003 However, based on this SCOD removal in the nitrification step, a consequent post-denitrification process without nitrate recycle and dosage of external carbon sources has been proven to reach substantial nitrate elimination of up to 20 mg nitrogen per litre at COD/N-ratios of approx. Nitrates 204-211 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 24-27 12509525-9 2003 These results identify an anion transporter that functions in stomatal opening and demonstrate that CHL1 supports stomatal function in the presence of nitrate. Nitrates 151-158 cell adhesion molecule L1 like Homo sapiens 100-104 12487131-3 2002 This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride/nitrate-selectivity. Nitrates 127-134 frataxin Homo sapiens 41-46 12488138-7 2002 Collectively, our results suggest that MPO released by activated neutrophils during inflammation utilizes physiological or pathological levels of NO 2 - to nitrate proteins, and may provide an additional mechanism in addition to ONOO - formation, for tissue injury in ARDS and other inflammatory diseases associated with upregulated *NO and oxidant production. Nitrates 156-163 myeloperoxidase Homo sapiens 39-42 12442170-8 2002 HAR1 encodes a putative serine/threonine receptor kinase, which is required for shoot-controlled regulation of root growth, nodule number, and for nitrate sensitivity of symbiotic development. Nitrates 147-154 CM0216.560.nc Lotus japonicus 0-4 12194970-6 2002 Our studies demonstrate that levels of nitric oxide that are likely to be encountered in the vicinity of airway cells during inflammation may nitrate CFTR resulting in enhanced degradation and decreased function. Nitrates 142-149 CF transmembrane conductance regulator Homo sapiens 150-154 12390892-1 2002 Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration. Nitrates 33-40 nitric oxide synthase 2 Homo sapiens 142-173 12390892-1 2002 Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration. Nitrates 33-40 nitric oxide synthase 2 Homo sapiens 175-179 12270552-3 2002 In this study, we show the varying concentrations of nitrite and nitrate present in different body fluids during AK-5 tumor growth and regression in Wistar rats. Nitrates 65-72 adenylate kinase isoenzyme 5 Rattus norvegicus 113-117 12411410-5 2002 After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium. Nitrates 160-167 leptin Mus musculus 26-32 12411410-5 2002 After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium. Nitrates 160-167 interferon gamma Mus musculus 80-89 12433163-1 2002 Riparian zones have been found to function as "sinks" for nitrate (NO3-), the most common groundwater pollutant in the U. S., in many areas. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 12436367-8 2002 The connection between increased nitric oxide production and the haemodynamic sequelae of portal hypertension is also apparent in the significant correlation between plasma renin and serum nitrate levels. Nitrates 189-196 renin Homo sapiens 173-178 12436367-9 2002 Circulating nitrate levels also correlated to the serum interleukin-6 levels. Nitrates 12-19 interleukin 6 Homo sapiens 56-69 12177001-10 2002 Our studies indicate that AQP6 exhibits a new form of anion permeation with marked specificity for nitrate conferred by a specific pore-lining residue, observations that imply that the primary role of AQP6 may be in cellular regulation rather than simple fluid transport. Nitrates 99-106 aquaporin 6 Homo sapiens 26-30 12177001-10 2002 Our studies indicate that AQP6 exhibits a new form of anion permeation with marked specificity for nitrate conferred by a specific pore-lining residue, observations that imply that the primary role of AQP6 may be in cellular regulation rather than simple fluid transport. Nitrates 99-106 aquaporin 6 Homo sapiens 201-205 12382055-8 2002 Phenotype analysis showed that the moeA gene is required for A. mediterranei growth in a minimal medium with nitrate as sole nitrogen source, possibly because nitrate reductase activity is diminished due to disruption of the moeA gene. Nitrates 109-116 molybdopterin molybdotransferase MoeA Amycolatopsis mediterranei U32 35-39 12384050-8 2002 The most advantageous configuration tested, where nitrate assimilation (as well as that of ammonium) continued at a high rate in darkness as long as C-reserves remained, is not actually used in migratory species but in non-migratory diatoms. Nitrates 50-57 steroid sulfatase Homo sapiens 146-150 12202921-8 2002 Because nitrate/nitrite shifted the balance from a Th1 to a Th2 response in some individuals, exposure to these compounds may decrease these persons" responsiveness to infectious diseases. Nitrates 8-15 negative elongation factor complex member C/D Homo sapiens 51-54 12298004-3 2002 The magneto-switchable activation and deactivation of the electrochemical oxidation of the ferrocene-functionalized magnetic particles and the electrochemical reduction of the bipyridinium-functionalized magnetic particles are used for the triggering of mediated bioelectrocatalytic oxidation of glucose, in the presence of glucose oxidase (GOx), and bioelectrocatalytic reduction of nitrate (NO(3) (-)), in the presence of nitrate reductase (NR), respectively. Nitrates 384-391 hydroxyacid oxidase 1 Homo sapiens 324-339 12298004-3 2002 The magneto-switchable activation and deactivation of the electrochemical oxidation of the ferrocene-functionalized magnetic particles and the electrochemical reduction of the bipyridinium-functionalized magnetic particles are used for the triggering of mediated bioelectrocatalytic oxidation of glucose, in the presence of glucose oxidase (GOx), and bioelectrocatalytic reduction of nitrate (NO(3) (-)), in the presence of nitrate reductase (NR), respectively. Nitrates 384-391 hydroxyacid oxidase 1 Homo sapiens 341-344 12208366-6 2002 Of special interest has been the finding that XOR can catalyze the reduction of nitrates and nitrites to nitric oxide (NO), acting as a source of both NO and peroxynitrite. Nitrates 80-88 xanthine dehydrogenase Homo sapiens 46-49 12369617-3 2002 Using this vector a plant nitrate reductase cDNA (tobacco Nia2) was expressed for the first time in a nitrate assimilatory yeast. Nitrates 26-33 nitrate reductase [NADH] 2 Nicotiana tabacum 58-62 12230634-6 2002 The decreased insulin response was associated with significant elevation of nitric oxide produced from GSNO and SNAP co-administered with vitamin C, as assessed by plasma nitrate/nitrite levels. Nitrates 171-178 insulin Canis lupus familiaris 14-21 12358336-9 2002 In iNOS-deficient mice, both iNOS expression and NT formation were completely abolished, and the total amounts of nitrite and nitrate in BAL fluid were significantly decreased. Nitrates 126-133 nitric oxide synthase 2, inducible Mus musculus 3-7 12396394-7 2002 The estimated median intake of lead and nitrate per kg body weight from tap water was higher in FF infants than in BF infants or mixed fed (MF) young children. Nitrates 40-47 USO1 vesicle transport factor Homo sapiens 72-75 12226143-6 2002 RESULTS: Leptin increased plasma concentrations of NO metabolites (nitrates + nitrites, NO(x)) by 32.5%, 58.0%, and 29.7% at 1, 2, and 4 hours, respectively. Nitrates 67-75 leptin Rattus norvegicus 9-15 12171788-3 2002 METHODS AND RESULTS: After gene transfer, expression of eNOS in cultured cells was detected by increased intracellular cGMP and nitrate/nitrite levels and NO synthase activity. Nitrates 128-135 nitric oxide synthase 3 Rattus norvegicus 56-60 12196158-8 2002 Prior investigations have shown that the absence of CymA results in loss of the ability to respire with Fe(III), fumarate and nitrate, indicating that CymA is involved in electron transfer to several terminal reductases. Nitrates 126-133 cytochrome c Shewanella oneidensis MR-1 52-56 12196158-8 2002 Prior investigations have shown that the absence of CymA results in loss of the ability to respire with Fe(III), fumarate and nitrate, indicating that CymA is involved in electron transfer to several terminal reductases. Nitrates 126-133 cytochrome c Shewanella oneidensis MR-1 151-155 12192137-1 2002 The rare earth metal(III) trifluoromethanesulfonate (rare earth metal(III) triflate, RE(OTf)3) was found to be an efficient catalyst for aromatic nitration with carboxylic anhydride-inorganic nitrate as the nitrating agent. Nitrates 192-199 POU class 5 homeobox 1 Homo sapiens 85-93 12196104-9 2002 The increase in NR activity resulted in a significant decrease in nitrate level. Nitrates 66-73 NADH nitrate reductase Solanum tuberosum 16-18 12193069-0 2002 Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro. Nitrates 49-56 endothelin 1 Homo sapiens 98-110 12193069-1 2002 The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Nitrates 23-30 endothelin 1 Homo sapiens 64-76 12193069-1 2002 The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro. Nitrates 23-30 endothelin 1 Homo sapiens 78-82 12165428-3 2002 The genes YNT1, YNR1 and YNI1, encoding respectively nitrate transport, nitrate reductase and nitrite reductase, have been cloned, as well as two other genes encoding transcriptional regulatory factors. Nitrates 53-60 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 10-14 12139615-9 2002 The promoters of most of these Dam-controlled genes were also found to contain GATC sequences that overlap with recognition sites for two global regulators, fumarate nitrate reduction (Fnr) and catabolite activator protein (CRP). Nitrates 166-173 catabolite gene activator protein Escherichia coli 194-228 12172843-4 2002 The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation. Nitrates 132-139 uncharacterized protein Chlamydomonas reinhardtii 213-217 12172843-1 2002 The expression of nitrite uptake activity and the induction of transcripts from several nitrate assimilation genes (Nii1, Nrt2;1, Nrt2;3, and Nar1) have been analysed in Chlamydomonas reinhardtii Dang. Nitrates 88-95 uncharacterized protein Chlamydomonas reinhardtii 116-120 12172843-4 2002 The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation. Nitrates 132-139 uncharacterized protein Chlamydomonas reinhardtii 213-217 12172843-4 2002 The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation. Nitrates 34-41 uncharacterized protein Chlamydomonas reinhardtii 213-217 12172843-4 2002 The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation. Nitrates 132-139 uncharacterized protein Chlamydomonas reinhardtii 213-217 12230195-1 2002 A novel in situ membrane technology was developed to remove nitrate (NO3-) from groundwater. Nitrates 60-67 NBL1, DAN family BMP antagonist Homo sapiens 69-72 12198187-6 2002 The astray seedlings showed normal sensitivity to the general inhibitors of nodulation such as ethylene and nitrate. Nitrates 108-115 ASTRAY Lotus japonicus 4-10 12052727-1 2002 Nitrites and nitrates are widely used reporters of endogenous activity of nitric oxide synthases (NOS), an important group of enzymes producing the gaseous signal molecule nitric oxide (NO). Nitrates 13-21 nitric oxide synthase 2 Homo sapiens 74-96 12099927-6 2002 Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group. Nitrates 87-94 interleukin 6 Homo sapiens 70-74 12069938-6 2002 TNF-alpha caused significant inhibition of ACh- and bradykinin-induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats. Nitrates 103-110 tumor necrosis factor Rattus norvegicus 0-9 12093672-5 2002 Levels of nitrite and/or nitrate in the serum were elevated within 2 h after administration of IL-18, reaching a peak at 4 h and then decreasing gradually to the basal level over a 24-h period of time. Nitrates 25-32 interleukin 18 Mus musculus 95-100 12115884-6 2002 Induction of iNOS was confirmed by measurement of nitrate/nitrite production and by immunodetection. Nitrates 50-57 nitric oxide synthase 2 Homo sapiens 13-17 12127127-9 2002 Plasma and intestinal levels of the nitric oxide products, nitrite/nitrate, were increased in the iNOS +/+ mice fed the TPN solution but not in the chow-fed groups or the iNOS -/- mice receiving TPN solution. Nitrates 67-74 nitric oxide synthase 2, inducible Mus musculus 98-102 12068127-4 2002 Using a reverse genetic approach, the AtNRT2.1 gene has been shown to be involved in the inducible component of the high-affinity nitrate transport system in Arabidopsis. Nitrates 130-137 nitrate transporter 2:1 Arabidopsis thaliana 38-46 12154133-8 2002 The expression of the three genes was also induced by nitrate supplement but the induction was most prominent and transient in AtpOMT1 similar to nitrate reductase gene. Nitrates 54-61 nitrate reductase 1 Arabidopsis thaliana 146-163 12044161-0 2002 Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism. Nitrates 53-60 cyclin dependent kinase 2 Homo sapiens 30-34 12044161-0 2002 Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism. Nitrates 53-60 cyclin A2 Homo sapiens 35-43 12044161-3 2002 The crystal structure of pCDK2/cyclin A in complex with Mg(2+)ADP, nitrate, and a heptapeptide substrate has been determined at 2.7 A. Nitrates 67-74 cyclin A2 Homo sapiens 31-39 12044161-6 2002 Kinetic studies demonstrate that nitrate is not an effective inhibitor of protein kinases, consistent with the structural results that show the nitrate ion makes few stabilizing interactions with CDK2 at the catalytic site. Nitrates 144-151 cyclin dependent kinase 2 Homo sapiens 196-200 12003849-0 2002 Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II. Nitrates 35-42 angiotensinogen Rattus norvegicus 69-83 12003849-7 2002 Control responses were restored by SOD, MnTBAP, or losartan, suggesting a role for elevated angiotensin II and reactive oxygen species (ROS) as mediators of the attenuated NO dilation (nitrate tolerance). Nitrates 185-192 angiotensinogen Rattus norvegicus 92-106 12003849-9 2002 In summary, terminal arterioles are affected by nitrates to a greater extent than the arcade arterioles that feed them, in a process dependent on angiotensin II and ROS. Nitrates 48-56 angiotensinogen Rattus norvegicus 146-160 12087347-2 2002 Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance. Nitrates 74-81 renin Homo sapiens 18-23 12087347-2 2002 Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance. Nitrates 131-138 renin Homo sapiens 18-23 12087347-8 2002 CONCLUSION: Our results suggest that angiotensin II may attenuate the arterial vasodilating effect of glyceryl trinitrate through angiotensin type 1 receptors and presumably through receptor-mediated superoxide production, which may be relevant to the development of nitrate tolerance. Nitrates 114-121 angiotensinogen Homo sapiens 37-51 12058245-4 2002 Thus, nitrates enhance the production of cyclic GMP and combined with phosphodiesterase type-5 inhibitors this can lead to severe hypotension. Nitrates 6-14 5'-nucleotidase, cytosolic II Homo sapiens 48-51 11943658-3 2002 Incubation of transplant AMs with SP-A increased intracellular Ca(2+) concentration ([Ca(2+)](i)) by 70% and nitrite and nitrate (NO(x)) production by 45% (from 0.24 +/- 0.02 to 1.3 +/- 0.21 nmol small middle dot 10(6) AMs(-1).h(-1)). Nitrates 121-128 surfactant protein A1 Homo sapiens 34-38 12060247-9 2002 We were able to restore wild-type levels of NRA in ipt-expressing plants by simultaneous induction of NR with BA and nitrate. Nitrates 117-124 Ipt Agrobacterium tumefaciens 51-54 12006803-10 2002 Increased serum nitrate (micromoles of NO2 + NO3) concentrations were detected in septic patients, compared with controls, but no differences were found between survivor (91.84 +/- 14.12) and nonsurvivor (102.6 +/- 17.36) groups. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 45-48 11976082-4 2002 Insertional inactivation of the nitrite reductase structural gene or its transcriptional regulator, NnrR, in strain 2.4.3 caused a loss of a taxis response towards both nitrate and nitrite. Nitrates 169-176 AWN88_RS06525 Agrobacterium tumefaciens 32-49 12000675-0 2002 Nitrate signalling on the nitrate reductase gene promoter depends directly on the activity of the nitrate transport systems in Chlamydomonas. Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 26-43 12021246-9 2002 Our observations provide strong evidence that myeloperoxidase generates reactive nitrogen species in vivo and that it operates in this fashion only when nitrite and nitrate become available. Nitrates 165-172 myeloperoxidase Mus musculus 46-61 12061138-6 2002 Nicorandil, a hybrid of an ATP sensitive K+ (KATP) channel opener and nitrate, increases the level of interstitial adenosine via cGMP-mediated activation of ecto-5"-nucleotidase. Nitrates 70-77 5' nucleotidase, ecto Rattus norvegicus 157-177 12000675-1 2002 Nitrate signalling on the nitrate reductase (Nia1) gene promoter from Chlamydomonas reinhardtii has been studied by using a construct of the Nia1 promoter transcriptionally fused to the Chlamydomonas arylsulphatase gene as a reporter in strains bearing different sets of nitrate/nitrite transport genes. Nitrates 0-7 uncharacterized protein Chlamydomonas reinhardtii 26-43 12010476-9 2002 The results may mean that AMF-colonization positively affects nitrate uptake from soil and nitrate allocation to the plant partner, probably mediated preferentially by LeNRT2;3. Nitrates 62-69 nitrate transporter NRT2.3 Solanum lycopersicum 168-176 12010476-9 2002 The results may mean that AMF-colonization positively affects nitrate uptake from soil and nitrate allocation to the plant partner, probably mediated preferentially by LeNRT2;3. Nitrates 91-98 nitrate transporter NRT2.3 Solanum lycopersicum 168-176 12133319-16 2002 (4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P < 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P > 0.05). Nitrates 92-100 matrix metallopeptidase 2 Rattus norvegicus 61-66 12059056-5 2002 In addition, iNOS expression in circulating monocytes was assessed by Western blotting, immunocytochemistry and measurement of the NO metabolites nitrite and nitrate in plasma. Nitrates 158-165 nitric oxide synthase 2 Homo sapiens 13-17 12133319-16 2002 (4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P < 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P > 0.05). Nitrates 244-252 matrix metallopeptidase 2 Rattus norvegicus 61-66 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 126-133 radixin Homo sapiens 160-163 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 16-23 radixin Homo sapiens 42-45 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 126-133 radixin Homo sapiens 160-163 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 126-133 radixin Homo sapiens 42-45 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 126-133 radixin Homo sapiens 160-163 12153019-9 2002 The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present. Nitrates 126-133 radixin Homo sapiens 160-163 12081242-10 2002 We concluded that the decrease in nitrate/nitrite concentration in preovulatory follicles after hCG injection was due mainly to decreased iNOS expression in granulosa cells. Nitrates 34-41 nitric oxide synthase 2 Rattus norvegicus 138-142 11939777-2 2002 The NapB protein is essential in transferring electrons to the large catalytic subunit NapA, which subsequently reduces nitrate to nitrite. Nitrates 120-127 NSF attachment protein beta Homo sapiens 4-8 11939777-8 2002 We propose a hypothetical but plausible model of the NapAB complex in which the four redox centers are positioned in a virtually linear configuration which spans a distance of nearly 40 A, suggesting an efficient pathway for the transfer of electrons from NapC, the physiological electron donor of NapB, to a nitrate molecule at the catalytic site of NapA. Nitrates 309-316 NSF attachment protein beta Homo sapiens 298-302 11912238-4 2002 Later in the diurnal cycle an orchestrated increase of GLN2, PKc, CS, and ICDH-1 expression re-establishes a balance between nitrate assimilation and ammonium metabolism. Nitrates 125-132 glucan endo-1,3-beta-glucosidase, basic vacuolar Nicotiana tabacum 55-59 11912225-2 2002 Two classes of genes, NRT1 and NRT2, have been found to be potentially involved in the high and low affinity nitrate transport systems (HATS and LATS, respectively). Nitrates 109-116 nitrate transporter 1.1 Arabidopsis thaliana 22-26 11954828-7 2002 PARP-/- mice, and their wild-type littermate showed a similar time-dependent increase in plasma nitrite/nitrate and in gut and lung MDA content, as well as the presence of nitrotyrosine in the gut. Nitrates 104-111 poly (ADP-ribose) polymerase family, member 1 Mus musculus 0-4 11912225-2 2002 Two classes of genes, NRT1 and NRT2, have been found to be potentially involved in the high and low affinity nitrate transport systems (HATS and LATS, respectively). Nitrates 109-116 nitrate transporter 2:1 Arabidopsis thaliana 31-35 11912225-3 2002 The complexity of the molecular basis of nitrate uptake has been enhanced by the finding that in many plants both NRT1 and NRT2 classes are represented by multigene families. Nitrates 41-48 nitrate transporter 1.1 Arabidopsis thaliana 114-118 11912225-3 2002 The complexity of the molecular basis of nitrate uptake has been enhanced by the finding that in many plants both NRT1 and NRT2 classes are represented by multigene families. Nitrates 41-48 nitrate transporter 2:1 Arabidopsis thaliana 123-127 11912225-5 2002 This is a review of recent progress in the characterization of the NRT2 nitrate transporters, the composition of this family in Arabidopsis, their possible role in nitrate acquisition, and some aspects of their regulation in plants. Nitrates 72-79 nitrate transporter 2:1 Arabidopsis thaliana 67-71 11912226-1 2002 The AtNRT1.1 (CHL1) gene of Arabidopsis encodes a dual-affinity nitrate transporter and contributes to both low and high affinity nitrate uptake. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 4-12 11912226-1 2002 The AtNRT1.1 (CHL1) gene of Arabidopsis encodes a dual-affinity nitrate transporter and contributes to both low and high affinity nitrate uptake. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 14-18 11912227-4 2002 In Chlamydomonas reinhardtii, the Nar1;1 gene has been shown to have this role in nitrate assimilation. Nitrates 82-89 NAR1.1 Chlamydomonas reinhardtii 34-40 11922726-1 2002 The nitrate form of the Group III transitional element gallium (GN) increases expression of specific structural components of the provisional wound matrix (i.e., collagen type I, fibronectin) in human dermal fibroblasts. Nitrates 4-11 fibronectin 1 Homo sapiens 179-190 11921102-1 2002 Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha. Nitrates 0-7 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 59-63 11921102-1 2002 Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha. Nitrates 0-7 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 164-168 11921102-1 2002 Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha. Nitrates 38-45 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 164-168 11814459-5 2002 There was a weak but significant correlation between the nitrite/nitrate and endothelin-1 concentrations in the NP and NTP groups (r(1)=0.46, P<0.05, and r(2)=0.38, P<0.05, respectively) which probably revealed the balance between these vasoactive factors. Nitrates 65-72 endothelin 1 Homo sapiens 77-89 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrates 220-227 interleukin 12b Mus musculus 9-17 11990929-10 2002 The nitrate concentration change was paralleled by the systemic inflammatory response syndrome, as indicated by alterations of myeloperoxidase activity and by impaired histologic and cellular membrane integrity in tissues and organs. Nitrates 4-11 myeloperoxidase Rattus norvegicus 127-142 12148533-12 2002 The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response. Nitrates 112-119 Transmembrane amino acid transporter family protein Arabidopsis thaliana 43-47 11878390-2 2002 This method is similar to U.S. Environmental Protection Agency method 353.2 and U.S. Geological Survey method 1-2545-90 except that nitrate is reduced to nitrite by soluble nitrate reductase (NaR, EC 1.6.6.1) purified from corn leaves rather than a packed-bed cadmium reactor. Nitrates 132-139 nitrate reductase [NADH] 1 Zea mays 173-190 11823513-7 2002 Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels. Nitrates 220-227 interferon gamma Mus musculus 27-36 11792648-8 2002 Basal and ACh-induced nitrite/nitrate production was less in TNF-alpha-infused than in control pregnant rats. Nitrates 30-37 tumor necrosis factor Rattus norvegicus 61-70 11863253-6 2002 RESULTS: A twofold increase in plasma TNF-alpha levels in pregnant rats resulted in a significant increase in arterial pressure (97 +/- 3.6 v 116 +/- 2.1 mm Hg, pregnant versus TNF-alpha pregnant, respectively, P < .05), but no significant change in urinary nitrite/nitrate excretion (22.0 +/- 1.9 v 20.8 +/- 2.5 micromol/24 h, pregnant versus TNF-alpha pregnant, respectively), a measure of whole body NO production. Nitrates 269-276 tumor necrosis factor Rattus norvegicus 38-47 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrates 118-125 coagulation factor III, tissue factor Homo sapiens 19-21 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrates 118-125 serpin family E member 1 Homo sapiens 26-31 11858480-6 2002 RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p <0.05), the development of MOF (p <0.05), and mortality (p <0.05). Nitrates 118-125 serpin family E member 1 Homo sapiens 45-50 12442789-1 2002 This paper assesses the distribution of ammonium (NH4+) and nitrate (NO3-) nitrogen deposition in native bushland soil adjacent to an open ventilated poultry farm. Nitrates 60-67 NBL1, DAN family BMP antagonist Homo sapiens 69-72 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrates 113-120 interleukin 1 beta Rattus norvegicus 5-13 11755929-4 2002 Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs. Nitrates 113-120 tumor necrosis factor Rattus norvegicus 18-27 11924581-4 2002 The nitrate removal rate per unit volume of sulfur layer can be expressed as alpha (ALR)n, where ALR is the applied loading rate. Nitrates 4-11 growth factor, augmenter of liver regeneration Homo sapiens 84-87 11924581-4 2002 The nitrate removal rate per unit volume of sulfur layer can be expressed as alpha (ALR)n, where ALR is the applied loading rate. Nitrates 4-11 growth factor, augmenter of liver regeneration Homo sapiens 97-100 12077491-12 2002 In multivariate analysis, significant independent predictors of fDH were older age (OR = 1.04 [1.02-1.07]), lack of glomerulonephritis as renal diagnosis (2.63 [1.18-5.87]), high phosphorus levels (5.0 [2.45-10.0]), lack of use of Ca-channel blockers (2.09 [1.12-3.91]), and the use of nitrates (2.38 [1.24-4.55]). Nitrates 286-294 alcohol dehydrogenase 5 (class III), chi polypeptide Homo sapiens 64-67 12638758-3 2002 The surface runoff was negligible and therefore the according nitrate fluxes as welL Soil water analysis revealed mean nitrate concentrations of 3 to 15 mg NO3 L(-1), depending on soil depth. Nitrates 119-126 NBL1, DAN family BMP antagonist Homo sapiens 156-159 12638758-4 2002 The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 91-94 12638758-4 2002 The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 116-119 12638758-4 2002 The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 116-119 12210732-7 2002 On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels. Nitrates 96-103 interleukin 1 beta Mus musculus 19-27 12210732-7 2002 On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels. Nitrates 96-103 negative elongation factor complex member C/D, Th1l Mus musculus 31-34 11902126-2 2002 Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects. Nitrates 152-159 6-pyruvoyltetrahydropterin synthase Homo sapiens 14-50 11902126-2 2002 Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects. Nitrates 152-159 sepiapterin reductase Homo sapiens 52-73 11793130-6 2002 Urinary nitrite + nitrate excretion was significantly lower in iNOS KO mice compared to control animals at all time points; in C57 mice, urinary nitrite declined progressively with more prolonged duration of diabetes. Nitrates 18-25 nitric oxide synthase 2, inducible Mus musculus 63-67 16228527-3 2002 The activity of nitrate reductase (NR), the first and rate-limiting step in the assimilation of nitrate into amino acids in leaves, is subjected to a varied range of regulatory influences including a robust circadian rhythm. Nitrates 16-23 nitrate reductase [NADH] Solanum lycopersicum 35-37 25696028-8 2002 Nitrates and NO-donors reduce SBP more than DBP because of their effects on the large conduit arteries. Nitrates 0-8 selenium binding protein 1 Homo sapiens 30-33 12051519-7 2002 Endothelin-1 additions diminished nitrate and nitrite levels in embryos from both control and n-stz diabetic rats, whereas bosentan stimulated nitrate and nitrite generation in those embryos. Nitrates 34-41 endothelin 1 Rattus norvegicus 0-12 11788764-3 2002 In leaves, GS2 functions to assimilate ammonia produced by nitrate reduction and photorespiration, and GS1 is the major isoform assimilating NH3 produced by all other metabolic processes, including symbiotic N2 fixation in the nodules. Nitrates 59-66 glutamine synthetase precursor Glycine max 11-14 12189042-10 2002 However, oxygenated myoglobin readily reacts with *NO to yield higher order N-oxides such as nitrate, while both the ferrous and ferric forms of the protein form a stable complex with *NO. Nitrates 93-100 myoglobin Homo sapiens 20-29 12688525-7 2002 The appearance and disappearance of P450 isoforms paralleled the conversion of organic nitrates to NO as assessed by immunohistochemistry and Western blotting. Nitrates 87-95 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 12688525-2 2002 We studied the rat P450 (CYP)-catalyzed conversion of organic nitrate to nitric oxide (NO) by purified CYP isoforms and the relationship between P450 expression and nitrate tolerance following continuous infusion of organic nitrates in rats. Nitrates 62-69 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-23 12688525-8 2002 Our observations indicate that nitrate tolerance is in large part the result of decreased P450 expression and activity. Nitrates 31-38 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 90-94 11735412-7 2001 First, metHb prevents the peroxynitrite-mediated nitration of a target dipeptide, Ala-Tyr, and second, it promotes the isomerization of peroxynitrite to nitrate. Nitrates 153-160 hemoglobin subunit gamma 2 Homo sapiens 7-12 12805744-1 2001 An investigation of air pollution in the Tehran metropolitan area between 1992-2000 indicated that there are significant amounts of nitrate ion (NO3-), over 30 kg/ha/year, deposited as wet deposition, compared to 13 kg/ha/year in the Chitgar Parkland near the Tehran metropolitan area. Nitrates 132-139 NBL1, DAN family BMP antagonist Homo sapiens 145-148 11936646-3 2002 Simulation studies using the Simulation Benchmark developed in the European COST program show that both objectives can be achieved by maintaining the nitrate concentration at the outlet of the anoxic zone at around 2 mgN/L. Nitrates 150-157 helt bHLH transcription factor Homo sapiens 217-220 11730359-9 2001 Plasma and urine nitrite/nitrate levels were significantly lower in l-NAME-treated Thy-1 rats compared to nontreated Thy-1 rats. Nitrates 25-32 Thy-1 cell surface antigen Rattus norvegicus 83-88 11811525-8 2001 The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0. Nitrates 37-44 NBL1, DAN family BMP antagonist Homo sapiens 46-49 11811525-8 2001 The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0. Nitrates 37-44 catalase Homo sapiens 64-72 12805808-2 2001 Nitrate (NO3-) concentration in soil solution at the treated site was significantly higher than that of the control in the no-snow period, and it was decreased by dilution from melting snow. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 12805811-2 2001 These high rates of deposition have translated into consistently high levels of nitrate (NO3-) in some streams of the San Bernardino Mountains. Nitrates 80-87 NBL1, DAN family BMP antagonist Homo sapiens 89-92 12805813-8 2001 The ratio of mean monthly headwater nitrate (NO3-) concentration to precipitation NO3- concentration declined with increased precipitation concentration. Nitrates 36-43 NBL1, DAN family BMP antagonist Homo sapiens 45-48 12805837-2 2001 This leads to a series of environmental impacts, including: (1) nitrate (NO3) contamination of drinking water, (2) eutrophication of freshwater lakes, (3) acidification and biodiversity impacts on terrestrial ecosystems, (4) ozone and particle formation affecting human health, and (5) global climate change induced by emissions of N2O. Nitrates 64-71 NBL1, DAN family BMP antagonist Homo sapiens 73-76 11700425-6 2001 In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively. Nitrates 56-63 TNF receptor superfamily member 1A Homo sapiens 83-89 12805781-1 2001 Studies with established turf and golf courses have indicated minimal risk of nitrate pollution of groundwater resulting from turfgrass management, but soil nitrate flux in turfgrass sod production farms and golf courses has received less attention. Nitrates 157-164 superoxide dismutase 1 Homo sapiens 183-186 12805781-2 2001 Information about nitrate-N flux at a particular location can be helpful to the sod producer or the golf course manager when efficiently applying N fertilizers and minimizing risk of nitrate pollution. Nitrates 18-25 superoxide dismutase 1 Homo sapiens 80-83 11700425-6 2001 In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively. Nitrates 56-63 TNF receptor superfamily member 1B Homo sapiens 112-118 11690645-6 2001 Maximal expression of a nirK-lacZ fusion in strain USDA110 required simultaneously both low level oxygen conditions and the presence of nitrate. Nitrates 136-143 nitrite reductase, copper-containing Bradyrhizobium diazoefficiens USDA 110 24-28 11568845-14 2001 Sulfates (SO4) and nitrates (NO3) are found in the area in low concentrations, even below the WHO standards for drinking water, but are significantly higher in the surface water compared to the groundwater. Nitrates 19-27 NBL1, DAN family BMP antagonist Homo sapiens 29-32 11583718-12 2001 The increase in the serum level of nitrite/nitrate after 3 months of estrogen therapy showed a significant inverse correlation (r=0.52, P<0.01) with the reduction in the plasma level of ACE activity. Nitrates 43-50 angiotensin I converting enzyme Homo sapiens 189-192 11642005-3 2001 TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.) Nitrates 113-121 tumor necrosis factor Mus musculus 0-9 11534936-8 2001 RESULTS: In the acute phase of colitis, intracolonic nitrite/nitrate levels were significantly higher in the 100 and 500 mg supplemented L-Arg groups than in D-Arg group. Nitrates 61-68 Rho guanine nucleotide exchange factor 12 Rattus norvegicus 137-142 11641309-10 2001 Among the antihypertensive agents, nitrates, NO donors, and drugs that interfere with the renin-angiotensin-aldosterone system may offer useful tools to lower pulse pressure, in addition to mean blood pressure. Nitrates 35-43 renin Homo sapiens 90-95 12060296-6 2001 The NiR gene is expressed in roots and leaves, although the level of expression is much higher in roots, in accordance with the fact that L. japonicus assimilates nitrate mainly in roots. Nitrates 163-170 nir Lotus japonicus 4-7 12060296-7 2001 NiR mRNA, protein and activity are induced by nitrate in roots and leaves, while ammonium-grown plants only showed basal levels. Nitrates 46-53 nir Lotus japonicus 0-3 11552025-2 2001 The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p < 0.001), whereas the concentrations in plasma were similar. Nitrates 24-31 colony stimulating factor 2 Homo sapiens 41-44 11602386-1 2001 Nitrite (NO2-) and nitrate (NO3-) concentrations are usually measured as a marker of NO metabolism. Nitrates 19-26 NBL1, DAN family BMP antagonist Homo sapiens 28-31 11517313-4 2001 We find that, at biologically relevant O(2) concentrations, HMP preferentially binds NO (not O(2)), which it then reacts with oxygen to form nitrate (in essence NO(-) + O(2) --> NO(3)(-)). Nitrates 141-148 inner membrane mitochondrial protein Homo sapiens 60-63 11553762-7 2001 Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase. Nitrates 56-63 ferredoxin--nitrite reductase, chloroplastic Solanum lycopersicum 120-137 11553762-7 2001 Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase. Nitrates 56-63 transaldolase Solanum lycopersicum 169-182 11553762-7 2001 Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase. Nitrates 56-63 malate dehydrogenase Solanum lycopersicum 199-219 11553762-7 2001 Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase. Nitrates 56-63 asparagine synthetase Solanum lycopersicum 221-242 11580101-3 2001 Aminoguanidine, a selective inducible NO synthase inhibitor, abolished the inhibition of neutrophil migration and the increase in serum nitrate levels induced by a nonlethal dose of LPS. Nitrates 136-143 nitric oxide synthase 2, inducible Mus musculus 28-49 11479842-7 2001 The low levels of LMVEC iNOS expression are associated with a 4-fold lower nitrite and nitrate production. Nitrates 87-94 nitric oxide synthase 2 Homo sapiens 24-28 11487691-1 2001 The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs. Nitrates 65-72 nitrate transporter 1.1 Arabidopsis thaliana 4-12 11487691-1 2001 The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs. Nitrates 65-72 nitrate transporter 1.1 Arabidopsis thaliana 14-18 11487691-1 2001 The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs. Nitrates 189-196 nitrate transporter 1.1 Arabidopsis thaliana 4-12 11530952-2 2001 The eventual fate of NO is oxidation to nitrite (NO2) and nitrate (NO3), both of which are end-products of NO metabolism. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 11487691-1 2001 The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs. Nitrates 189-196 nitrate transporter 1.1 Arabidopsis thaliana 14-18 11421931-3 2001 The purpose of the study was to examine serum nitrate (NO3) levels in relation to the disease severity in children with AD. Nitrates 46-53 NBL1, DAN family BMP antagonist Homo sapiens 55-58 11459488-1 2001 A detailed investigation of the spin-lattice relaxation time, T1, for 207Pb in solid lead nitrate has been undertaken in an effort to understand the mechanism of relaxation. Nitrates 90-97 spindlin 1 Homo sapiens 32-36 11442316-2 2001 A severe inflammatory response characterized by peritoneal exudation, high peritoneal levels of nitrate/nitrite, and leukocyte infiltration into peritoneal exudate was induced by zymosan administration in iNOS +/+ mice. Nitrates 96-103 nitric oxide synthase 2, inducible Mus musculus 205-209 11425809-5 2001 Significantly lower concentrations of plasma nitrate (P < 0.01) were measured at the end of gonadotrophin-releasing hormone (GnRH) down-regulation (24.6 micromol/l +/- 1.4) compared with the concentrations found at day 8 of follicle-stimulating hormone (FSH) stimulation (34.9 micromol/l +/- 2.6) and at the day of human chorionic gonadotrophin (HCG) (35.6 micromol/l +/- 3.3). Nitrates 45-52 chorionic gonadotropin subunit beta 5 Homo sapiens 324-353 11442316-5 2001 Peritoneal administration of zymosan in the iNOS +/+ mice induced also a significant increase in the plasma levels of nitrite/nitrate and in the levels of peroxynitrite at 18 h after zymosan challenge. Nitrates 126-133 nitric oxide synthase 2, inducible Mus musculus 44-48 11407704-8 2001 RESULTS: In iNOS+/+ animals with AIA, the plasma concentration of nitrite/nitrate was increased 3-fold and iNOS expression was detected in cells of the joint. Nitrates 74-81 nitric oxide synthase 2, inducible Mus musculus 12-16 11384769-6 2001 Furthermore, the administration of apelin-12 (10 nmol/kg) in rats produced a transitory elevation of the plasma nitrite/nitrate concentration from a basal level of 21.4+/-1.6 to 27.0+/-1.5 microM. Nitrates 120-127 apelin Rattus norvegicus 35-41 11556575-1 2001 Nitrate levels in CSF and sera from 16 coma and 19 noncoma falciparum malaria patients were determined using nitric oxide colorometric assay. Nitrates 0-7 colony stimulating factor 2 Homo sapiens 18-21 11440734-9 2001 Correlation analysis revealed significant inverse correlation between nitrate levels and VEGF. Nitrates 70-77 vascular endothelial growth factor A Homo sapiens 89-93 11556575-3 2001 The medians of nitrate level in CSF of coma and noncoma cases were 0.09 (0.01, 0.28) and 0.15 (0, 1.18) microM, respectively. Nitrates 15-22 colony stimulating factor 2 Homo sapiens 32-35 11337842-1 2001 Water quality associated with nitrate (NO3-) leaching from agricultural soils is an important environmental issue. Nitrates 30-37 NBL1, DAN family BMP antagonist Homo sapiens 39-42 11402201-1 2001 Transgenic plants of Arabidopsis bearing the spinach (Spinacia oleracea) nitrite reductase (NiR, EC 1.7.7.1) gene that catalyzes the six-electron reduction of nitrite to ammonium in the second step of the nitrate assimilation pathway were produced by use of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator. Nitrates 205-212 nitrite reductase 1 Arabidopsis thaliana 73-90 11402201-1 2001 Transgenic plants of Arabidopsis bearing the spinach (Spinacia oleracea) nitrite reductase (NiR, EC 1.7.7.1) gene that catalyzes the six-electron reduction of nitrite to ammonium in the second step of the nitrate assimilation pathway were produced by use of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator. Nitrates 205-212 nitrite reductase 1 Arabidopsis thaliana 92-95 11432445-1 2001 Plasma nitrite (NO2-) and nitrate (NO3-) are the stable end-products of endogenous nitric oxide (NO) metabolism. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 35-38 11259452-7 2001 However, BRE expression was downregulated in human adrenal adenoma and pheochromocytoma, whereas its expression was enhanced in abnormal adrenal tissues of rats chronically treated with nitrate or nitrite. Nitrates 186-193 BRISC and BRCA1 A complex member 2 Homo sapiens 9-12 11394308-0 2001 An integrated relay/nitrate reductase field-effect transistor for the sensing of nitrate (NO3-). Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 90-93 11394308-7 2001 The devices that include the bipyridinium units tethered to the gate interface with methylene chain length, -(CH2)n, where n > or = 7, reveal a detection limit of 7 x 10(-5) M for nitrate and a sensitivity of 52 +/- 2 mV dec-1. Nitrates 183-190 deleted in esophageal cancer 1 Homo sapiens 224-229 11411856-5 2001 Nitrate concentration in the greenhouse effluent can be reduced to acceptable levels for the protection of freshwater aquatic life (i.e., less then 40 ppm) using a loading rate of 1.65 g NO3-N/m2/day and a design water depth of 30 cm or greater. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 187-190 11351772-1 2001 As a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra) is safe and effective in men with erectile dysfunction (ED) of diverse aetiologies, including patients with common cardiovascular diseases who are not receiving organic nitrates or nitrate donor drugs. Nitrates 304-312 phosphodiesterase 5A Homo sapiens 100-104 11351772-1 2001 As a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra) is safe and effective in men with erectile dysfunction (ED) of diverse aetiologies, including patients with common cardiovascular diseases who are not receiving organic nitrates or nitrate donor drugs. Nitrates 304-311 phosphodiesterase 5A Homo sapiens 100-104 11240977-1 2001 OBJECTIVE: An enhanced circulatory angiotensin II level that results from the administration of nitroglycerin may contribute to the development of nitrate tolerance. Nitrates 147-154 angiotensinogen Homo sapiens 35-49 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrates 56-63 toll-like receptor 4 Mus musculus 15-18 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrates 157-164 toll-like receptor 4 Mus musculus 123-126 11292369-4 2001 Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine. Nitrates 157-164 toll-like receptor 4 Mus musculus 123-126 11258960-9 2001 This result indicates that, as confirmed from protein analysis after reacting the proteins with NO* for 10 times, when peroxynitrite is coordinated to the heme of myoglobin or hemoglobin it rapidly isomerizes to nitrate without nitrating the globins in physiologically significant amounts. Nitrates 212-219 myoglobin Homo sapiens 163-172 11222615-0 2001 snr-1 gene is required for nitrate reduction in Pseudomonas aeruginosa PAO1. Nitrates 27-34 cytochrome C Snr1 Pseudomonas aeruginosa PAO1 0-5 11288970-0 2001 Dobutamine as bridge to angiotensin-converting enzyme inhibitor-nitrate therapy in endstage heart failure. Nitrates 64-71 angiotensin I converting enzyme Homo sapiens 24-53 11288970-12 2001 CONCLUSIONS: Of the patients on dobutamine inotropic support, 70% were successfully transitioned to ACE inhibitor-nitrate therapy, with improved symptoms and LVEF, and with reduced hospitalizations and follow-up dobutamine or transplant. Nitrates 114-121 angiotensin I converting enzyme Homo sapiens 100-103 11222615-6 2001 An isogenic snr-1::Gm insertional mutant was unable to grow aerobically with nitrate as a sole nitrogen source or anaerobically with nitrate as an electron acceptor. Nitrates 133-140 cytochrome C Snr1 Pseudomonas aeruginosa PAO1 12-17 11222615-6 2001 An isogenic snr-1::Gm insertional mutant was unable to grow aerobically with nitrate as a sole nitrogen source or anaerobically with nitrate as an electron acceptor. Nitrates 77-84 cytochrome C Snr1 Pseudomonas aeruginosa PAO1 12-17 11244107-9 2001 Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize. Nitrates 81-88 nitrate reductase [NADH] 1 Zea mays 194-196 11244107-9 2001 Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize. Nitrates 142-149 nitrate reductase [NADH] 1 Zea mays 64-66 11244107-9 2001 Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize. Nitrates 142-149 nitrate reductase [NADH] 1 Zea mays 194-196 11289303-2 2001 For assimilation of nitrate (and nitrite) there are two types of uptake system known: ABC transporters that are driven by ATP hydrolysis, and secondary transporters reliant on a proton motive force. Nitrates 20-27 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 86-89 11165253-0 2001 An arabidopsis T-DNA mutant affected in Nrt2 genes is impaired in nitrate uptake. Nitrates 66-73 nitrate transporter 2:1 Arabidopsis thaliana 40-44 11165253-1 2001 Expression analyses of Nrt2 plant genes have shown a strict correlation with root nitrate influx mediated by the high-affinity transport system (HATS). Nitrates 82-89 nitrate transporter 2:1 Arabidopsis thaliana 23-27 11165253-5 2001 Moreover, the de-regulated expression of a Nicotiana plumbaginifolia Nrt2 gene restored the mutant nitrate influx to that of the wild-type. Nitrates 99-106 nitrate transporter 2:1 Arabidopsis thaliana 69-73 11351735-6 2001 From the sum of the contributions of particles on the Teflon and nylon filters of the PMDS, nitrate formation almost completely accounts for chloride depletion in PM2.5 prior to collection since the equivalent ratio of [Na+] to ([NO3-] + [Cl-]) is close to the seawater ratio of 0.85. Nitrates 92-99 NBL1, DAN family BMP antagonist Homo sapiens 230-233 11165878-6 2001 The concentrations of RSNOs, nitrate, and nitrated LDL were positively correlated to those of total cholesterol, LDL cholesterol, and apoB. Nitrates 29-36 apolipoprotein B Homo sapiens 134-138 11227283-10 2001 Nitrate and DON displayed contrasting seasonal trends; NO3 concentrations were larger in the winter while DON concentrations were larger in the summer. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 55-58 11208643-1 2001 Levels of nitrite (NO2-) and nitrate (NO3-) were measured in pulmonary edema fluid and plasma from 34 patients with early acute lung injury (ALI) and 20 patients with hydrostatic pulmonary edema. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 38-41 11550504-1 2001 The end products of nitric oxide (NO) metabolism in human organism, i.e. anions, nitrites (NO2) and nitrates (NO3), are excreted predominantly (95%) via urine. Nitrates 100-108 NBL1, DAN family BMP antagonist Homo sapiens 110-113 11450112-7 2001 Evidence is emerging that Nap fulfills a novel role in nitrate scavenging by some pathogenic bacteria. Nitrates 55-62 catenin beta like 1 Homo sapiens 26-29 11237288-5 2001 More than 94% of the N2O was from the reduction of NO3-, probably due to aerobic nitrate respiration as well as respiratory denitrification. Nitrates 81-88 NBL1, DAN family BMP antagonist Homo sapiens 51-54 11201500-2 2001 Recently, 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) was shown to potentiate vascular smooth muscle responsiveness to glyceryl trinitrate (GTN), sodium nitroprusside, and the nitric oxide donor NOC 18, in organic nitrate-naive vascular smooth muscle. Nitrates 141-148 RNA binding motif single stranded interacting protein 1 Homo sapiens 58-62 11201500-3 2001 We used GTN-tolerant rabbit aortic rings (RARs) to test the hypothesis that a non-vasorelaxant concentration of YC-1 enhances the ability of the prototypical organic nitrate GTN to relax vascular smooth muscle and elevate intravascular cGMP under conditions of GTN tolerance. Nitrates 166-173 RNA binding motif single stranded interacting protein 1 Homo sapiens 112-116 11215662-3 2001 This investigation studied the attenuation of nitrate (NO3- -N) as wastewater effluent flowed through the shallow ground water of a forested headwater riparian zone within the Appalachian Valley and Ridge physiographic province. Nitrates 46-53 NBL1, DAN family BMP antagonist Homo sapiens 55-58 11688686-5 2001 The results showed that redox processes with nitrate, manganese oxide and ferric iron as the electron acceptors exhibited hydrogen threshold values close to PCE/TCE dechlorination, whereas cis-DCE and VC dechlorinations exhibited hydrogen threshold values in the range of sulfate reduction and methanogenesis, respectively. Nitrates 45-52 24-dehydrocholesterol reductase Homo sapiens 193-196 11216852-1 2001 Nitrate reductase (NR; EC 1.6.6.1) is the first enzyme of the nitrate-assimilatory pathway and is regulated transcriptionally and post-translationally by several metabolic and environmental signals. Nitrates 62-69 nitrate reductase [NADH]-like Cucumis sativus 0-17 11216852-1 2001 Nitrate reductase (NR; EC 1.6.6.1) is the first enzyme of the nitrate-assimilatory pathway and is regulated transcriptionally and post-translationally by several metabolic and environmental signals. Nitrates 62-69 nitrate reductase [NADH]-like Cucumis sativus 19-21 11216852-9 2001 It is concluded that, in cucumber plants, the rate of CO2 assimilation controls the rate of nitrate assimilation by modulation of NR expression and activity, and that sugars are presumably involved as regulatory metabolites. Nitrates 92-99 nitrate reductase [NADH]-like Cucumis sativus 130-132 11881452-0 2001 [Effects of hyperbaric oxygenation and ceruloplasmin on redox processes and phosphorylation associated with them in the salivary glands in chronic nitrate intoxication]. Nitrates 147-154 ceruloplasmin Homo sapiens 39-52 11587558-8 2001 The increases paralleled the increases in ALT levels with peak levels of serum nitrate plus nitrite at 6 h (168 +/- 27 microM). Nitrates 79-86 glutamic pyruvic transaminase, soluble Mus musculus 42-45 11957779-6 2001 In 1986 WHO fixed the limit of the contents of nitrates in drinking water to 10 mg N-NO3-/dm3 (45 mg NO3-/dm3). Nitrates 47-55 NBL1, DAN family BMP antagonist Homo sapiens 85-88 11957779-6 2001 In 1986 WHO fixed the limit of the contents of nitrates in drinking water to 10 mg N-NO3-/dm3 (45 mg NO3-/dm3). Nitrates 47-55 NBL1, DAN family BMP antagonist Homo sapiens 101-104 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 31-38 phenylalanine hydroxylase Homo sapiens 0-3 11756889-7 2001 Nitrate (NO3) was 49.8 +/- 5.0 micromol/L in patients with PDR and 24.2 +/- 2.8 micromol/L in patients with macula hole; it was also significantly elevated in patients with PDR (P = 0.004, Mann-Whitney), whereas nitrite (NO2) was not detected in this study. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 31-38 phenylalanine hydroxylase Homo sapiens 120-123 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 92-99 phenylalanine hydroxylase Homo sapiens 0-3 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 92-99 phenylalanine hydroxylase Homo sapiens 120-123 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 92-99 phenylalanine hydroxylase Homo sapiens 0-3 11257884-7 2001 PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction. Nitrates 92-99 phenylalanine hydroxylase Homo sapiens 120-123 11257884-13 2001 PAH degradation was approximately stoichiometric with the amount of nitrate consumed. Nitrates 68-75 phenylalanine hydroxylase Homo sapiens 0-3 11257889-12 2001 The procedure uses the second derivative of the absorption spectrum for nitrate (NO3-), which has a peak at approximately 224 nm that is proportional to the NO3- concentration. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 11257889-12 2001 The procedure uses the second derivative of the absorption spectrum for nitrate (NO3-), which has a peak at approximately 224 nm that is proportional to the NO3- concentration. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 157-160 11137498-7 2000 Because PDE5 is also present in small amounts in the systemic vasculature, sildenafil can cause a synergistic and major decrease in pressure when combined with organic nitrates. Nitrates 168-176 phosphodiesterase 5A Homo sapiens 8-12 11116119-4 2000 In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis. Nitrates 200-207 nitric oxide synthase 3 Rattus norvegicus 9-13 11116119-4 2000 In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis. Nitrates 200-207 nitric oxide synthase 3 Rattus norvegicus 52-56 11221914-2 2000 The present study was undertaken to determine whether plasma levels of the NO metabolites nitrate (NO3-) and nitrite (NO2-) in the systemic and cavernous blood of male subjects change during different penile conditions, and whether there is a difference in the NO3- and NO2- levels of normal males and patients with erectile dysfunction (ED). Nitrates 90-97 NBL1, DAN family BMP antagonist Homo sapiens 99-102 11098975-13 2000 iNOS+/+ mice subjected to SMAO had increased plasma concentrations of nitrite (NO2-) and nitrate (NO3-), and the plasma concentrations of NO2- and NO3- were highest in the mice in which bacterial translocation had occurred. Nitrates 89-96 nitric oxide synthase 2, inducible Mus musculus 0-4 11052959-5 2000 NOS2 activation was estimated by mRNA (RT-PCR) and protein (Western-blot) expression and plasma nitrate/nitrite accumulation. Nitrates 96-103 nitric oxide synthase 2 Rattus norvegicus 0-4 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrates 8-15 interleukin 1 beta Rattus norvegicus 47-69 11063722-6 2000 The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T-->C mutation were significantly lower than among those without the mutation. Nitrates 107-114 nitric oxide synthase 3 Homo sapiens 44-48 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrates 8-15 tumor necrosis factor Rattus norvegicus 73-106 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrates 8-15 mitogen activated protein kinase 3 Rattus norvegicus 192-195 11131279-5 2000 Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A). Nitrates 8-15 mitogen activated protein kinase kinase 1 Rattus norvegicus 318-325 11046058-5 2000 Incubating LPS-primed monocytes with NCX-4016 resulted in intracellular NO formation as assessed by measuring nitrite/nitrate, intracellular cGMP concentration, and intracellular NO formation. Nitrates 118-125 T cell leukemia homeobox 2 Homo sapiens 37-40 10986217-2 2000 We have previously shown that protection against D-galactosamine (D-GalN) induced liver injury by prostaglandin E(1) (PGE(1)) was accompanied by an increase in TNF-alpha and nitrite/nitrate in serum. Nitrates 182-189 galanin and GMAP prepropeptide Rattus norvegicus 68-72 11001767-5 2000 Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold. Nitrates 59-66 angiotensinogen Homo sapiens 0-14 11001767-5 2000 Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold. Nitrates 59-66 angiotensinogen Homo sapiens 16-22 11026644-7 2000 N(G)-nitro-L-arginine methyl ester (L-NAME) lowered the basal concentration of plasma nitrate, abolished the increase in plasma nitrate elicited by angiotensin II and norepinephrine, and potentiated the pressor effect of the low dose of angiotensin II, although this dose did not increase NO production. Nitrates 128-135 angiotensinogen Homo sapiens 148-162 11026644-2 2000 This study intended to determine first, whether NO-derived plasma nitrate varies in response to increases in blood pressure induced by different mechanical and pharmacologic stimuli, including angiotensin II and catecholamines; and second, specifically to study the interaction between angiotensin II and NO production. Nitrates 66-73 angiotensinogen Homo sapiens 193-207 11028657-6 2000 Oxymetazoline and xylometazoline were shown to have a dose dependent inhibitory effect on total iNOS activity indicated by nitrite/nitrate formation in the Griess assay. Nitrates 131-138 nitric oxide synthase 2 Rattus norvegicus 96-100 11026644-6 2000 The intermediate and high dose, but not the low dose, of angiotensin II increased plasma nitrate concentration. Nitrates 89-96 angiotensinogen Homo sapiens 57-71 11022123-8 2000 Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p < 0.05), nitrate and sTNFr-I (p < 0.05), nitrate and sTNFr-II (p < 0.05), and between IL-6 and IL-10 (p < 0.05), respectively. Nitrates 61-68 interleukin 6 Homo sapiens 73-77 11022123-8 2000 Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p < 0.05), nitrate and sTNFr-I (p < 0.05), nitrate and sTNFr-II (p < 0.05), and between IL-6 and IL-10 (p < 0.05), respectively. Nitrates 61-68 interleukin 6 Homo sapiens 189-193 11022123-8 2000 Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p < 0.05), nitrate and sTNFr-I (p < 0.05), nitrate and sTNFr-II (p < 0.05), and between IL-6 and IL-10 (p < 0.05), respectively. Nitrates 61-68 interleukin 10 Homo sapiens 198-203 10954746-5 2000 A strong correlation between methemoglobin and plasma nitrate formation was observed, suggesting that NO metabolism is a primary physiological cause of hemoglobin oxidation. Nitrates 54-61 hemoglobin subunit gamma 2 Homo sapiens 29-42 10936493-8 2000 Increase of nitrite and nitrate (as an index of NO formation) in the hippocampus, as observed after ischemia, was reduced in animals treated with recombinant human erythropoietin. Nitrates 24-31 erythropoietin Homo sapiens 164-178 10983841-13 2000 These findings suggest that increased production of nitrate in PE may contribute to homeostatic vasodilation against vasoconstriction caused by a higher ET-1 concentration. Nitrates 52-59 endothelin 1 Homo sapiens 153-157 10983841-0 2000 The relationship between serum nitrate and endothelin-1 concentrations in preeclampsia. Nitrates 31-38 endothelin 1 Homo sapiens 43-55 10948265-3 2000 Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated. Nitrates 18-25 nitrate reductase 1 Arabidopsis thaliana 68-85 10983841-8 2000 There was a significant correlation between NOx (nitrite + nitrate) and ET-1 in sera from all 44 women (NP, NTP and PE groups) (p<0.001). Nitrates 59-66 endothelin 1 Homo sapiens 72-76 10983841-11 2000 However, there was a significant correlation between nitrate and ET-1 in sera from the PE group (p<0.05). Nitrates 53-60 endothelin 1 Homo sapiens 65-69 10948265-3 2000 Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated. Nitrates 18-25 nitrate transporter 1.1 Arabidopsis thaliana 111-115 10948265-3 2000 Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated. Nitrates 18-25 glutamate synthase 1 Arabidopsis thaliana 121-139 10948265-4 2000 Novel nitrate-induced genes were also found, including those encoding (1) possible regulatory proteins, including an MYB transcription factor, a calcium antiporter, and putative protein kinases; (2) metabolic enzymes, including transaldolase and transketolase of the nonoxidative pentose pathway, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase; and (3) proteins with unknown functions, including nonsymbiotic hemoglobin, a senescence-associated protein, and two methyltransferases. Nitrates 6-13 malate dehydrogenase Arabidopsis thaliana 297-317 10948265-7 2000 Two genes, AMT1;1 encoding an ammonium transporter and ANR1 encoding a MADS-box factor, were repressed by nitrate. Nitrates 106-113 anthranilate synthase alpha subunit 1 Arabidopsis thaliana 11-15 10916096-10 2000 Kallikrein gene delivery significantly decreased total urinary protein and albumin excretion and increased levels of urinary kinin, nitrite/nitrate, and cGMP levels. Nitrates 140-147 kallikrein related peptidase 4 Homo sapiens 0-10 10948265-7 2000 Two genes, AMT1;1 encoding an ammonium transporter and ANR1 encoding a MADS-box factor, were repressed by nitrate. Nitrates 106-113 AGAMOUS-like 44 Arabidopsis thaliana 55-59 10814817-3 2000 In order to identify cis-acting DNA-elements involved in light and nitrate induction of the birch NiR gene, a 0.9 kb 5" flanking region of the NiR gene was isolated, analysed on the DNA level, and the transcription start site was determined. Nitrates 67-74 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 98-101 10909895-5 2000 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Nitrates 88-95 nitric oxide synthase 2 Rattus norvegicus 100-121 10909895-5 2000 In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline. Nitrates 88-95 nitric oxide synthase 2 Rattus norvegicus 123-127 10814817-4 2000 Deletion analysis of the birch NiR promoter region fused to the GUS reporter gene (uidA) in transgenic tobacco (Nicotiana tabacum) revealed the presence of light- and nitrate-responsive promoter fragments. Nitrates 167-174 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 31-34 10887287-1 2000 The interaction of organic nitrates (nitroethyleneglycol, dinitroglycerol, and their esters with arachidonic acid) with oxyhemoglobin and methemoglobin has been studied. Nitrates 27-35 hemoglobin subunit gamma 2 Homo sapiens 138-151 10918945-0 2000 Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension. Nitrates 129-136 angiotensin I converting enzyme Homo sapiens 72-101 10981158-5 2000 All classes of antihypertensive drugs reduce pulse pressure by means of lowering peripheral resistance, but certain drugs like nitrates, angiotensin converting enzyme inhibitors, and other drugs affecting the renin-angiotensin system have multiple actions that improve large artery stiffness and early wave reflection and are especially useful in treating ISH in the elderly. Nitrates 127-135 renin Homo sapiens 209-214 10840402-0 2000 Markedly elevated nitrate/nitrite levels in the cerebrospinal fluid of children with progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO syndrome). Nitrates 18-25 coiled-coil domain containing 88A Homo sapiens 159-163 10807981-9 2000 Indeed, nitrite/nitrate was positive in 70% of AFP-negative HCC patients. Nitrates 16-23 alpha fetoprotein Homo sapiens 47-50 10883943-3 2000 This study was to determine the tolerance for high doses of angiotensin-converting enzyme (ACE) inhibitor-nitrates in women versus men and to compare their symptomatic response, exercise tolerance, and ventricular functional improvement over 1 year. Nitrates 106-114 angiotensin I converting enzyme Homo sapiens 60-89 10883943-3 2000 This study was to determine the tolerance for high doses of angiotensin-converting enzyme (ACE) inhibitor-nitrates in women versus men and to compare their symptomatic response, exercise tolerance, and ventricular functional improvement over 1 year. Nitrates 106-114 angiotensin I converting enzyme Homo sapiens 91-94 10883943-5 2000 For all patients, ACE inhibitor-nitrate therapy was intensified. Nitrates 32-39 angiotensin I converting enzyme Homo sapiens 18-21 10883943-14 2000 Thus, both women and men tolerated uptitrated ACE inhibitor-nitrate medical therapy, with comparable reversal of heart failure remodeling. Nitrates 60-67 angiotensin I converting enzyme Homo sapiens 46-49 10811574-10 2000 For nitrate levels > 25 mg/L, an increased SIR and an increased IRR of 1.46 were observed; however, this increase was not statistically significant, probably because of the small number of cases (15 of 1,064). Nitrates 4-11 insulin receptor related receptor Homo sapiens 67-70 10788454-3 2000 Total nitrate and nitrite production was completely abolished in cells from iNOS-deficient animals compared with control cells. Nitrates 6-13 nitric oxide synthase 2, inducible Mus musculus 76-80 10759614-2 2000 The changes in both the population spike amplitude and NO metabolites, nitrite (NO2-) and nitrate (NO3-), in the CA1 region were simultaneously determined before and after tetanic stimulation. Nitrates 90-97 carbonic anhydrase 1 Rattus norvegicus 113-116 10781002-15 2000 LPS pretreatment increased serum corticosterone levels in both mice, while it increased the serum nitrate/nitrite levels in wild-type but not in iNOS deficient mice. Nitrates 98-105 toll-like receptor 4 Mus musculus 0-3 10795767-1 2000 We have previously reported that ingestion of vegetables containing high nitrate (NO3-) increases breath nitrous oxide (N2O) concentration, probably due to denitrification. Nitrates 73-80 NBL1, DAN family BMP antagonist Homo sapiens 82-85 10807014-5 2000 The continuous infusion of 4-ABH4 efficiently suppressed the enhanced calcium-dependent/independent NO synthase activities induced by endotoxin in lung homogenates and completely suppressed the increase in plasma nitrite + nitrate caused by endotoxin at 5 h, with no significant difference compared with the L- NMMA treatment. Nitrates 223-230 abhydrolase domain containing 4, N-acyl phospholipase B Rattus norvegicus 29-33 10790841-3 2000 Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively. Nitrates 51-58 synemin Homo sapiens 170-173 10790841-3 2000 Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively. Nitrates 51-58 synemin Homo sapiens 174-177 10790841-3 2000 Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively. Nitrates 51-58 synemin Homo sapiens 174-177 10790841-3 2000 Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively. Nitrates 51-58 synemin Homo sapiens 174-177 10753096-12 2000 Increased production of methemoglobin and free radicals of nitric oxide and oxygen due to nitrate metabolism in the body lead to alveolar damage and mismatching of ventilation and perfusion, which may be the reason for high mortality in children due to RRTI. Nitrates 90-97 hemoglobin subunit gamma 2 Homo sapiens 24-37 10981145-6 2000 ANG II-induced ROS play a pivotal role in several pathophysiologic situations of vascular and renal cells such as hypertension, endothelial dysfunction, nitrate tolerance, atherosclerosis, and cellular remodeling. Nitrates 153-160 angiotensinogen Homo sapiens 0-6 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrates 137-144 interferon gamma Mus musculus 0-9 10731606-5 2000 We have also demonstrated that methyl viologen is an ineffective electron donor to Nap: its use leads to an underestimation of the contribution of Nap activity to the rate of nitrate reduction in vivo. Nitrates 175-182 catenin beta like 1 Homo sapiens 147-150 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrates 137-144 tumor necrosis factor Mus musculus 11-20 10705297-3 2000 IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite. Nitrates 137-144 interleukin 10 Mus musculus 25-30 10772174-7 2000 The limits of detection for nitrite and nitrate ions are 1 and 10 mg/kg, respectively. Nitrates 40-47 VPS52 subunit of GARP complex Homo sapiens 53-65 10671549-4 2000 Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis. Nitrates 141-148 superoxide dismutase 1 Homo sapiens 62-89 12212263-0 2000 [Derivative-ratio derivative spectrum method for determining nitrate and nitrite radicals (NO3- and NO2-) in environmental water]. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 91-94 12212263-4 2000 The results suggest that this method is better than ratio derivative spectrum method and it can be applied for determining nitrate and nitrite (NO3- and NO2-) in environment water samples. Nitrates 123-130 NBL1, DAN family BMP antagonist Homo sapiens 144-147 10671549-4 2000 Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis. Nitrates 141-148 superoxide dismutase 1 Homo sapiens 91-100 10631110-0 2000 Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells. Nitrates 13-21 tumor protein p53 Homo sapiens 60-63 10703687-5 2000 RESULTS: No significant differences between groups were detected at baseline except that patients with higher ACE inhibitor doses were more likely to take nitrates, beta-blockers and amiodarone, received higher furosemide doses and had higher serum gamma-glutamyl transferase levels. Nitrates 155-163 angiotensin I converting enzyme Homo sapiens 110-113 10677431-5 2000 Furthermore, contrasting the dual-affinity nitrate transport activity of CHL1, OsNRT1 displayed only low-affinity nitrate transport activity in Xenopus oocytes, with a K(m) value of approximately 9 mM. Nitrates 43-50 DEAD/H-box helicase 11 L homeolog Xenopus laevis 73-77 10631110-2 2000 As nitration of tyrosine residues in various proteins has been shown to inhibit their functions, we examined whether NO nitrates tyrosine residues in p53 protein. Nitrates 120-128 tumor protein p53 Homo sapiens 150-153 10620000-9 2000 CONCLUSION: We conclude that inhibition of glucose-stimulated insulin release by transdermal nitroglycerin without causing hyperglycaemia may serve as a novel component of the antianginal mechanism of action of nitrates. Nitrates 211-219 insulin Homo sapiens 62-69 10613864-6 2000 While MR1-CYMA retained menaquinone levels comparable to those of MR-1, it lost the ability to reduce iron(III), manganese(IV), and nitrate and to grow by using fumarate as an electron acceptor. Nitrates 132-139 cytochrome c Shewanella oneidensis MR-1 10-14 10642319-4 2000 Nitrate/nitrite production in AdeNOS-transduced ZG cells increased from 0.15+/-0.01 to 0.27+/-0.01 micromol/L after stimulation with 1 nmol/L angiotensin II. Nitrates 0-7 angiotensinogen Homo sapiens 142-156 10613864-8 2000 The requirement for CymA in anaerobic electron transport to iron(III), fumarate, nitrate, and manganese(IV) is therefore not dependent on the levels of menaquinone in these cells. Nitrates 81-88 cytochrome c Shewanella oneidensis MR-1 20-24 10631272-0 2000 Nitrite reductase mutants as an approach to understanding nitrate assimilation in Chlamydomonas reinhardtii. Nitrates 58-65 uncharacterized protein Chlamydomonas reinhardtii 0-17 10631272-4 2000 This finding confirms the previous role proposed for NR on its own regulation (autoregulation) and on the other genes for nitrate assimilation in C. reinhardtii. Nitrates 122-129 uncharacterized protein Chlamydomonas reinhardtii 53-55 10627036-7 1999 The ORF 5- and ORF 6-encoded proteins were shown by immunoblotting to be synthesized by cells grown in the presence of nitrate. Nitrates 119-126 ORF5 Clostridium perfringens 4-9 11247410-4 2000 The theories put forward to explain nitrate tolerance are examined, including recent work on vascular superoxide and endothelin-1 regulation. Nitrates 36-43 endothelin 1 Homo sapiens 117-129 10689548-6 1999 A significant correlation was shown between TGF-beta, and nitrate levels in all tissues (r = 0.24, P = 0.01), as well as in malignant tissues (r = 0.3, P = 0.026). Nitrates 58-65 transforming growth factor beta 1 Homo sapiens 44-52 10627036-7 1999 The ORF 5- and ORF 6-encoded proteins were shown by immunoblotting to be synthesized by cells grown in the presence of nitrate. Nitrates 119-126 ORF6 Clostridium perfringens 15-20 10627036-10 1999 Instead, all 5 ORFs downstream of ORF 6 are homologous to genes reported for molybdopterin biosynthesis, unlike the genomic organization already determined for the respiratory and assimilatory nitrate-reduction systems. Nitrates 193-200 ORF6 Clostridium perfringens 34-39 10541285-8 1999 Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla. Nitrates 83-90 kininogen 1 Canis lupus familiaris 41-51 10583588-2 1999 Continuous treatment with 5 mm or 10 mm l-N6-(1-imino-ethyl)-lysine (L-NIL), a selective NOS2-inhibitor, in acidified drinking water for up to 7 weeks consistently reduced infection-induced nitrate/nitrite to background levels in mycobacteria-infected BALB/c mice. Nitrates 190-197 nitric oxide synthase 2, inducible Mus musculus 89-93 10515827-4 1999 In contrast, higher levels of IL-6, IL-10, and MCP-1 in plasma and higher levels of IL-12, interferon (IFN)-gamma, and nitrite/nitrate were found in all compartments of TNF/Lt-alpha-deficient mice. Nitrates 127-134 tumor necrosis factor Mus musculus 169-172 10515827-5 1999 These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production. Nitrates 259-266 tumor necrosis factor Mus musculus 24-27 10515827-5 1999 These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production. Nitrates 259-266 lymphotoxin A Mus musculus 31-39 10645729-4 1999 ARS levels were very low in cells grown in the presence of NH4Cl and dramatically increased on agar medium deprived of any nitrogen source or containing nitrate, nitrite, urea, arginine or glutamine. Nitrates 153-160 uncharacterized protein Chlamydomonas reinhardtii 0-3 10645729-5 1999 Compared to nitrogen-free medium, a slight positive effect of nitrate in the NR+ strain and a significant negative effect of nitrite in both NR+ and NR- strains were observed. Nitrates 62-69 uncharacterized protein Chlamydomonas reinhardtii 77-79 10534444-4 1999 A significant decrease in the average postwounding urinary nitrate levels compared to prewounding levels was observed within the TGF-beta1 treatment group animals (P </= 0.001) with an insignificant change for the phosphate-buffered saline control animals (P </= 0.10). Nitrates 59-66 transforming growth factor, beta 1 Mus musculus 129-138 10546136-1 1999 This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator. Nitrates 178-186 plasminogen activator, tissue type Homo sapiens 285-318 10546136-1 1999 This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator. Nitrates 251-259 plasminogen activator, tissue type Homo sapiens 285-318 10511130-9 1999 Thus long-term ACE inhibition prevents nitrate tolerance by an endothelium-dependent mechanism involving mainly an enhanced NO availability via B2-kinin receptor. Nitrates 39-46 angiotensin I converting enzyme Rattus norvegicus 15-18 10490919-7 1999 The survival rate to endotoxin in mice was significantly (P <.01) increased by the presence of higenamine in the LPS-treated group up to 48 h. Serum nitrite/nitrate levels were significantly (P <.05) reduced by higenamine in LPS-treated rats. Nitrates 160-167 toll-like receptor 4 Mus musculus 116-119 10534444-5 1999 Additionally, TGF-beta1-treated animals showed significant connective tissue repair compared to controls without a concurrent increase in postwounding urinary nitrate levels, supporting the noninflammatory nature of the perforated mesentery model. Nitrates 159-166 transforming growth factor, beta 1 Mus musculus 14-23 10438436-7 1999 In the DHEA-S group, plasma circulating nitrate and nitrite increased significantly at 10 and 30 min after DHEA-S administration respectively (P < 0.05). Nitrates 40-47 sulfotransferase family 2A member 1 Homo sapiens 7-13 10512631-1 1999 The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1). Nitrates 175-182 opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan) Gallus gallus 198-206 10512631-1 1999 The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1). Nitrates 175-182 opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan) Gallus gallus 198-206 10512631-1 1999 The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1). Nitrates 290-297 opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan) Gallus gallus 31-39 10503839-8 1999 Nitrate levels were positively correlated with blood and 24 h urinary neopterin (e.g. plasma nitrate and blood neopterin: r = 0.54, P<0.0001), and in some cases, to C-reactive protein. Nitrates 0-7 C-reactive protein Homo sapiens 168-186 10438436-7 1999 In the DHEA-S group, plasma circulating nitrate and nitrite increased significantly at 10 and 30 min after DHEA-S administration respectively (P < 0.05). Nitrates 40-47 sulfotransferase family 2A member 1 Homo sapiens 107-113 11776556-2 1999 OBJECTIVE: To evaluate the clinical applications of the detection of the stable end products of NO, nitrite and nitrate (NO2-./NO3-.) Nitrates 112-119 NBL1, DAN family BMP antagonist Homo sapiens 127-130 10485617-4 1999 The vascular expression of bNOS as well as that of ecNOS was decreased along with tissue nitrite/nitrate contents in DOCA-salt and 2K1C hypertension. Nitrates 97-104 nitric oxide synthase 1 Rattus norvegicus 27-31 10485617-5 1999 The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents. Nitrates 102-109 nitric oxide synthase 1 Rattus norvegicus 23-27 10485617-5 1999 The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents. Nitrates 102-109 nitric oxide synthase 3 Rattus norvegicus 32-37 10449574-1 1999 The Arabidopsis CHL1 (AtNRT1) gene encodes an inducible component of low-affinity nitrate uptake, which necessitates a "two-component" model to account for the constitutive low-affinity uptake observed in physiological studies. Nitrates 82-89 nitrate transporter 1.1 Arabidopsis thaliana 16-20 10449574-1 1999 The Arabidopsis CHL1 (AtNRT1) gene encodes an inducible component of low-affinity nitrate uptake, which necessitates a "two-component" model to account for the constitutive low-affinity uptake observed in physiological studies. Nitrates 82-89 nitrate transporter 1.1 Arabidopsis thaliana 22-28 10449574-2 1999 Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake. Nitrates 188-195 nitrate transporter 1.1 Arabidopsis thaliana 54-58 10449574-2 1999 Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake. Nitrates 188-195 nitrate transporter 1:2 Arabidopsis thaliana 68-76 10449574-2 1999 Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake. Nitrates 188-195 nitrate transporter 1:2 Arabidopsis thaliana 95-99 10449574-3 1999 Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate. Nitrates 66-73 nitrate transporter 1.1 Arabidopsis thaliana 39-45 10449574-3 1999 Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate. Nitrates 110-117 nitrate transporter 1.1 Arabidopsis thaliana 39-45 10449574-3 1999 Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate. Nitrates 110-117 nitrate transporter 1.1 Arabidopsis thaliana 39-45 10449574-5 1999 Kinetic analysis of AtNRT1:2-injected Xenopus oocytes yielded a K(m) for nitrate of approximately 5.9 mM. Nitrates 73-80 nitrate transporter 1.1 Arabidopsis thaliana 20-26 10449574-6 1999 In contrast to CHL1, AtNRT1:2 was constitutively expressed before and after nitrate exposure (it was repressed transiently only when the level of CHL1 mRNA started to increase significantly), and its mRNA was found primarily in root hairs and the epidermis in both young (root tips) and mature regions of roots. Nitrates 76-83 nitrate transporter 1:2 Arabidopsis thaliana 21-29 10398706-0 1999 Simultaneous expression of NAD-dependent isocitrate dehydrogenase and other krebs cycle genes after nitrate resupply to short-term nitrogen-starved tobacco Mitochondrial NAD-dependent (IDH) and cytosolic NADP-dependent isocitrate dehydrogenases have been considered as candidates for the production of 2-oxoglutarate required by the glutamine synthetase/glutamate synthase cycle. Nitrates 100-107 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial Nicotiana tabacum 27-65 10381925-10 1999 Plasma nitrite/nitrate levels and hepatic NOS activity were increased significantly by CCl4 treatment. Nitrates 15-22 C-C motif chemokine ligand 4 Rattus norvegicus 87-91 10411000-3 1999 Incubation of fMLP-activated neutrophils with OH-L-Arg resulted in a production of nitrite, nitrate, and citrulline that was greater than with unstimulated neutrophils but was not inhibited by the NOS inhibitors L-NMMA and L-NIO or the cytochrome P450 inhibitor troleandomycin and was not seen when OH-L-Arg was replaced with L-Arg. Nitrates 92-99 formyl peptide receptor 1 Homo sapiens 14-18 10398706-1 1999 The increase in IDH transcripts in leaf and root tissues, induced by nitrate or NH4+ resupply to short-term N-starved tobacco (Nicotiana tabacum) plants, suggested that this enzyme could play such a role. Nitrates 70-77 isocitrate dehydrogenase [NADP] Nicotiana tabacum 17-20 10398706-2 1999 The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently. Nitrates 141-148 citrate synthase, glyoxysomal-like Nicotiana tabacum 47-63 10398706-2 1999 The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently. Nitrates 141-148 isocitrate dehydrogenase [NADP] Nicotiana tabacum 76-79 10398706-2 1999 The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently. Nitrates 141-148 glutamine synthetase Nicotiana tabacum 85-105 10503995-2 1999 NO is rapidly decomposed to nitrite (NO2-) and nitrate (NO3-). Nitrates 47-54 NBL1, DAN family BMP antagonist Homo sapiens 56-59 10407321-6 1999 By using this "reaction continuous-flow mass spectrometry" (R/CFMS) we developed methods for the (15)N determination of nitrite and nitrate from tracer experiment samples, i.e. artificially enriched in (15)N. Because both methods are based on the same principle, one continuous flow setup connected directly to a quadrupole mass spectrometer for all determinations was used. Nitrates 132-139 colony stimulating factor 1 receptor Homo sapiens 62-66 10377083-0 1999 Evidence for a causal role of the renin-angiotensin system in nitrate tolerance. Nitrates 62-69 LOW QUALITY PROTEIN: renin Oryctolagus cuniculus 34-39 10377083-2 1999 Both phenomena are stimulated by angiotensin II in vitro, and the renin-angiotensin system is activated during early nitrate therapy. Nitrates 117-124 LOW QUALITY PROTEIN: renin Oryctolagus cuniculus 66-71 10377083-3 1999 We hypothesized that either angiotensin II or ET-1 may increase vascular O2.- production during nitrate therapy. Nitrates 96-103 endothelin-1 Oryctolagus cuniculus 46-50 10377083-14 1999 CONCLUSIONS: The positive effects of AT1 and ET-1 receptor blockade on tolerance and O2.- production imply a pathophysiological role for angiotensin II and to some extent for ET-1 in the development of nitrate tolerance. Nitrates 202-209 endothelin-1 Oryctolagus cuniculus 45-49 10377083-14 1999 CONCLUSIONS: The positive effects of AT1 and ET-1 receptor blockade on tolerance and O2.- production imply a pathophysiological role for angiotensin II and to some extent for ET-1 in the development of nitrate tolerance. Nitrates 202-209 endothelin-1 Oryctolagus cuniculus 175-179 10380907-3 1999 We also investigated SP-induced formation of nitrite and nitrate as an index of nitric oxide (NO) production. Nitrates 57-64 tachykinin precursor 1 Homo sapiens 21-23 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrates 252-259 colony stimulating factor 3 Homo sapiens 35-40 10437653-5 1999 In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P < 0.05) following a 24-h incubation protocol. Nitrates 252-259 interferon gamma Homo sapiens 65-74 10338458-0 1999 Double-blind, placebo-controlled study to evaluate the effect of organic nitrates in patients with chronic heart failure treated with angiotensin-converting enzyme inhibition. Nitrates 73-81 angiotensin I converting enzyme Homo sapiens 134-163 10381142-7 1999 Substitution of chloride by gluconate enhanced basal steroid secretion, but nitrate completely abolished the effect of 1 IU/L hCG on androgen secretion, which could be partially overcome by increasing the gonadotropin concentration. Nitrates 76-83 chorionic gonadotropin subunit beta 5 Homo sapiens 126-129 10338458-10 1999 CONCLUSION: High-dose nitrate therapy significantly improves exercise tolerance and left ventricular size and systolic function in patients with chronic, mild to moderate CHF already treated with ACE inhibitors. Nitrates 22-29 angiotensin I converting enzyme Homo sapiens 196-199 10330425-13 1999 12-LO KO macrophages generated 50% less nitrate/nitrite when compared with C57BL/6 macrophages. Nitrates 40-47 arachidonate 15-lipoxygenase Mus musculus 0-5 10325247-14 1999 To our knowledge, this is the first demonstration that NO can promote NF-kappaB activation in the heart, a finding that identifies a new biological function of NO and may have important implications for various pathophysiological conditions in which NO is involved and for nitrate therapy. Nitrates 273-280 nuclear factor kappa B subunit 1 Homo sapiens 70-79 10385249-9 1999 Rh-EPO (25, 50 and 100 U 100 g(-1), 5 min following the onset of reperfusion) increased survival rate (70% at 4 h of reperfusion with the highest dose), reduced plasma nitrite/nitrate concentrations (10.3+/-3.3 microM), increased MAP, did not change RBC count and blood Hb, and inhibited iNOS activity in thoracic aortae. Nitrates 176-183 erythropoietin Rattus norvegicus 3-6 10359060-4 1999 LPS (200 microg/ml) significantly increased the production of nitrate within a 10-min incubation period. Nitrates 62-69 interferon regulatory factor 6 Homo sapiens 0-3 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrates 94-101 interleukin 1 beta Rattus norvegicus 5-27 10218970-4 1999 Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively. Nitrates 94-101 tumor necrosis factor Rattus norvegicus 32-65 10235127-6 1999 This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration. Nitrates 272-279 nitric oxide synthase 2 Rattus norvegicus 182-186 10330471-0 1999 CHL1 is a dual-affinity nitrate transporter of Arabidopsis involved in multiple phases of nitrate uptake. Nitrates 24-31 nitrate transporter 1.1 Arabidopsis thaliana 0-4 10367389-4 1999 The peak interfering with BCAA elutes at the same retention time as nitrate; however, we have not confirmed the presence of nitrate. Nitrates 68-75 AT-rich interaction domain 4B Homo sapiens 26-30 10330471-3 1999 Here, we demonstrate that a well-known low-affinity nitrate uptake mutant of Arabidopsis, chl1, is also defective in high-affinity nitrate uptake. Nitrates 52-59 nitrate transporter 1.1 Arabidopsis thaliana 90-94 10330471-3 1999 Here, we demonstrate that a well-known low-affinity nitrate uptake mutant of Arabidopsis, chl1, is also defective in high-affinity nitrate uptake. Nitrates 131-138 nitrate transporter 1.1 Arabidopsis thaliana 90-94 10330471-4 1999 Two to 3 hr after nitrate induction, uptake activities of various chl1 mutants at 250 microM nitrate (a high-affinity concentration) were only 18 to 30% of those of wild-type plants. Nitrates 18-25 nitrate transporter 1.1 Arabidopsis thaliana 66-70 10350003-0 1999 The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells. Nitrates 102-109 MAPK associated protein 1 Homo sapiens 23-28 10330471-4 1999 Two to 3 hr after nitrate induction, uptake activities of various chl1 mutants at 250 microM nitrate (a high-affinity concentration) were only 18 to 30% of those of wild-type plants. Nitrates 93-100 nitrate transporter 1.1 Arabidopsis thaliana 66-70 10330471-7 1999 Kinetic analysis of nitrate uptake by CHL1-injected Xenopus oocytes displayed a biphasic pattern with a Michaelis-Menten Km value of approximately 50 microM for the high-affinity phase and approximately 4 mM for the low-affinity phase. Nitrates 20-27 DEAD/H-box helicase 11 L homeolog Xenopus laevis 38-42 10330471-8 1999 These results indicate that in addition to being a low-affinity nitrate transporter, as previously recognized, CHL1 is also involved in both the inducible and constitutive phases of high-affinity nitrate uptake in Arabidopsis. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 111-115 10208844-6 1999 Treatment of rats with the selective iNOS inhibitor L-iminoethyl-lysine (L-NIL) dramatically reduced NO levels in lavage fluid as measured by decreases in nitrate and nitrite concentrations without significantly affecting iNOS protein levels. Nitrates 155-162 nitric oxide synthase 2 Rattus norvegicus 37-41 10190728-7 1999 In the overall series, a highly significant linear correlation between nitrites/nitrates and vWF:antigen levels was observed in patients with cirrhosis (r=0.79, p<0.001). Nitrates 80-88 von Willebrand factor Homo sapiens 93-96 10037703-3 1999 By using high performance anion-exchange chromatography (HPAEC) with nitrate eluents, we found that lactonization of alpha2,8-linked OSA/PSA (oligo/poly-Neu5Ac, oligo/poly-Neu5Gc and oligo/poly-KDN) proceeds readily, and the lactonization process displays three discrete stages. Nitrates 69-76 aminopeptidase puromycin sensitive Homo sapiens 137-140 10190728-4 1999 RESULTS: vWF:antigen and nitrite/nitrate levels were significantly higher in cirrhotic patients (367+/-185% and 29.3+/-10.8 micromol/l) than in healthy subjects (92+/-20% and 19.2+/-8.3 micromol/l, p<0.05, respectively). Nitrates 33-40 von Willebrand factor Homo sapiens 9-12 28307406-4 1999 We used this method to examine spatial patterns of soil ammonium (NH+4) and nitrate (NO-3) availability in a mid-successional coastal dune for four periods of time during the growing season. Nitrates 76-83 NBL1, DAN family BMP antagonist Homo sapiens 85-89 10190728-5 1999 Higher levels of vWF:antigen and nitrites/nitrates were observed in patients with more advanced degrees of liver failure, as reflected by quantitative Child-Pugh"s score (516+/-154% and 38.3+/-7.8 micromol/l in Child-Pugh > or = 9 vs 227+/-61% and 21.0+/-6.1 micromol/l in Child-Pugh <9, p<0.001, respectively). Nitrates 42-50 von Willebrand factor Homo sapiens 17-20 10203321-1 1999 To elucidate the involvement of NO in pain transmission in humans, we measured NO metabolites (nitrite/nitrate) in the CSF of patients with painful diseases using an NO analyzer based on the Griess method. Nitrates 103-110 colony stimulating factor 2 Homo sapiens 119-122 10205909-1 1999 Putative high-affinity nitrate (NO3-) transporter genes, designated Nrt2;1At and Nrt2;2At, were isolated from Arabidopsis thaliana by RT-PCR using degenerate primers. Nitrates 23-30 nitrate transporter 2:1 Arabidopsis thaliana 68-72 10205909-1 1999 Putative high-affinity nitrate (NO3-) transporter genes, designated Nrt2;1At and Nrt2;2At, were isolated from Arabidopsis thaliana by RT-PCR using degenerate primers. Nitrates 23-30 nitrate transporter 2:1 Arabidopsis thaliana 81-85 10205669-6 1999 The products of nitrate reduction i.e., nitrite and ammonium ion had inhibitory and stimulatory effects respectively, on NR transcript accumulation. Nitrates 16-23 nitrate reductase [NADH] 1 Zea mays 121-123 10063925-6 1999 Adrenomedullin levels had significant correlations with aldosterone (r = 0.55; P < 0.001), plasma renin activity (r = 0.49; P < 0.001) and nitrates-nitrites levels (r = 0.52; P < 0.001). Nitrates 145-153 adrenomedullin Homo sapiens 0-14 10205669-0 1999 Roles of nitrate, nitrite and ammonium ion in phytochrome regulation of nitrate reductase gene expression in maize. Nitrates 9-16 nitrate reductase [NADH] 1 Zea mays 72-89 10205669-1 1999 The influence of nitrate and its metabolites on the nitrate reductase (NR) gene expression and its relationship with phytochrome (Pfr) regulation of NR in etiolated maize leaves is examined. Nitrates 17-24 nitrate reductase [NADH] 1 Zea mays 52-69 10205669-1 1999 The influence of nitrate and its metabolites on the nitrate reductase (NR) gene expression and its relationship with phytochrome (Pfr) regulation of NR in etiolated maize leaves is examined. Nitrates 17-24 nitrate reductase [NADH] 1 Zea mays 71-73 9854041-8 1998 Thus, our novel mouse model of chronic eNOS overexpression demonstrates that, in addition to the essential role of eNOS in blood pressure regulation, tonic NO release by eNOS in the endothelium induces the reduced vascular reactivity to NO-mediated vasodilators, providing several insights into the pathogenesis of nitrate tolerance. Nitrates 315-322 nitric oxide synthase 3, endothelial cell Mus musculus 39-43 9845803-0 1999 Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers. Nitrates 57-64 trefoil factor 3 Homo sapiens 20-23 9845803-1 1999 ITF 296 is a new orally active nitrate acting selectively on large arterial vessels over a wide range of doses. Nitrates 31-38 trefoil factor 3 Homo sapiens 0-3 10362348-5 1999 Recent studies have shown that the use of nitrates in patients already treated with standard heart failure therapy, including angiotensin converting enzyme (ACE) inhibitors, resulted in hemodynamic improvement, marked enhancement of exercise tolerance, reduction of left ventricular size, and augmentation of systolic function. Nitrates 42-50 angiotensin I converting enzyme Homo sapiens 126-155 10362348-5 1999 Recent studies have shown that the use of nitrates in patients already treated with standard heart failure therapy, including angiotensin converting enzyme (ACE) inhibitors, resulted in hemodynamic improvement, marked enhancement of exercise tolerance, reduction of left ventricular size, and augmentation of systolic function. Nitrates 42-50 angiotensin I converting enzyme Homo sapiens 157-160 9844028-0 1998 The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake. Nitrates 65-72 nitrate transporter 1.1 Arabidopsis thaliana 16-20 9844028-8 1998 These results show that CHL1 is an important component of both the high-affinity and the low-affinity nitrate-uptake systems and indicate that CHL1 may be a dual-affinity nitrate transporter. Nitrates 102-109 nitrate transporter 1.1 Arabidopsis thaliana 24-28 9844028-8 1998 These results show that CHL1 is an important component of both the high-affinity and the low-affinity nitrate-uptake systems and indicate that CHL1 may be a dual-affinity nitrate transporter. Nitrates 102-109 nitrate transporter 1.1 Arabidopsis thaliana 143-147 9844028-1 1998 The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants. Nitrates 46-53 nitrate transporter 1.1 Arabidopsis thaliana 4-8 9844028-1 1998 The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants. Nitrates 46-53 nitrate transporter 1.1 Arabidopsis thaliana 10-14 9844028-1 1998 The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 4-8 9844028-1 1998 The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants. Nitrates 64-71 nitrate transporter 1.1 Arabidopsis thaliana 10-14 9844028-6 1998 chl1 mutants show reduced membrane depolarization in root epidermal cells in response to low (250 microM) and high (10 mM) concentrations of nitrate. Nitrates 141-148 nitrate transporter 1.1 Arabidopsis thaliana 0-4 9844028-7 1998 Low levels of nitrate (100 microM) induce a rapid increase in CHL1 mRNA. Nitrates 14-21 nitrate transporter 1.1 Arabidopsis thaliana 62-66 9821686-11 1998 The negative effect on the nia2 transcript pool exerted by exogeneous glutamine may, therefore, be explained as a result of the down-regulation of nitrate-uptake permeases in the roots by glutamine. Nitrates 147-154 nitrate reductase 2 Arabidopsis thaliana 27-31 9843849-2 1998 NO can combine with superoxide (O-2) to form peroxynitrite, which can decompose into nitrate. Nitrates 85-92 immunoglobulin kappa variable 1D-39 Homo sapiens 32-35 9843849-10 1998 These data demonstrate that O-2 released from PMNs can decrease NO by conversion to nitrate and suggest a potential mechanism for modulation of NO levels in vivo. Nitrates 84-91 immunoglobulin kappa variable 1D-39 Homo sapiens 28-31 9853182-0 1998 The impact of beta-receptor blocker addition to high-dose angiotensin-converting enzyme inhibitor-nitrate therapy in heart failure. Nitrates 98-105 angiotensin I converting enzyme Homo sapiens 58-87 9853182-3 1998 Similarly, high doses of angiotensin-converting enzyme (ACE) inhibitors with nitrates partially reverse the ventricular remodeling of heart failure. Nitrates 77-85 angiotensin I converting enzyme Homo sapiens 25-54 9853182-3 1998 Similarly, high doses of angiotensin-converting enzyme (ACE) inhibitors with nitrates partially reverse the ventricular remodeling of heart failure. Nitrates 77-85 angiotensin I converting enzyme Homo sapiens 56-59 9853182-4 1998 HYPOTHESIS: We tested the hypothesis that beta-blocker therapy added to high-dose ACE inhibitor-nitrates would potentiate the reversal of heart failure. Nitrates 96-104 angiotensin I converting enzyme Homo sapiens 82-85 9853182-13 1998 CONCLUSION: High-dose ACE inhibitor-nitrate therapy significantly improved patient clinical status and left ventricular systolic function in heart failure. Nitrates 36-43 angiotensin I converting enzyme Homo sapiens 22-25 9794807-0 1998 Clustering of the YNA1 gene encoding a Zn(II)2Cys6 transcriptional factor in the yeast Hansenula polymorpha with the nitrate assimilation genes YNT1, YNI1 and YNR1, and its involvement in their transcriptional activation. Nitrates 117-124 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 18-22 9794807-0 1998 Clustering of the YNA1 gene encoding a Zn(II)2Cys6 transcriptional factor in the yeast Hansenula polymorpha with the nitrate assimilation genes YNT1, YNI1 and YNR1, and its involvement in their transcriptional activation. Nitrates 117-124 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 144-148 9794807-2 1998 In addition, DNA sequencing of the region containing these genes demonstrated that a new open reading frame called YNA1 (yeast nitrate assimilation) was located between YNR1 and YNI1. Nitrates 127-134 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 115-119 9794807-3 1998 The YNA1 gene encodes a protein of 529 residues belonging to the family of Zn(II)2Cys6 fungal transcriptional factors, and has the highest similarity to the transcriptional factors encoded by nirA, and to a smaller extent to nit-4, involved in the nitrate induction of the gene involved in the assimilation of this compound in filamentous fungi. Nitrates 248-255 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 4-8 9794807-4 1998 Northern blot analysis showed the presence of the YNA1 transcript in cells incubated in nitrate, nitrate plus ammonium, ammonium, and nitrogen-free media, with a decrease in its levels in those cells incubated in ammonium. Nitrates 88-95 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 50-54 9794807-4 1998 Northern blot analysis showed the presence of the YNA1 transcript in cells incubated in nitrate, nitrate plus ammonium, ammonium, and nitrogen-free media, with a decrease in its levels in those cells incubated in ammonium. Nitrates 97-104 rRNA (cytosine-C5-)-methyltransferase NOP2 Saccharomyces cerevisiae S288C 50-54 9881153-9 1998 Expression studies at the protein and mRNA levels show that each subunit is present in both root and leaf tissues and that the three IDH genes respond in the same way to nitrate addition. Nitrates 170-177 isocitrate dehydrogenase [NADP] Nicotiana tabacum 133-136 9763537-7 1998 045), hypertriglyceridemia (P=0.015), and chronic intake of nitrates (P<0.001) were significantly and positively related to tPA antigen concentration, while the chronic intake of aspirin was inversely related to tPA antigen (P<0.001). Nitrates 60-68 plasminogen activator, tissue type Homo sapiens 127-130 9767541-6 1998 Kallikrein gene transfer caused left ventricular mass reduction and elevated glomerular filtration rate, renal blood flow, urinary excretion, urinary kinin, nitrite/nitrate content, cGMP and cAMP levels. Nitrates 165-172 kallikrein related peptidase 4 Homo sapiens 0-10 9811394-9 1998 There are a few studies assessing NO generation in hypertensive children via plasma nitrite and nitrate, the NO end products, which suggest normal or increased production as opposed to a reduction, perhaps as a compensatory phenomenon. Nitrates 96-103 nitric oxide synthase 2 Homo sapiens 34-36 9737004-0 1998 Clustering of the nitrite reductase gene and a light-regulated gene with nitrate assimilation loci in Chlamydomonas reinhardtii. Nitrates 73-80 uncharacterized protein Chlamydomonas reinhardtii 18-35 9788654-10 1998 Nitrate+nitrite levels returned to normal within 24 h. CRP generation increased during 12 h following trauma and was most marked in severest trauma (ISS >50). Nitrates 0-7 C-reactive protein Homo sapiens 55-58 9811394-10 1998 In the treatment of hypertension, nitroprusside and nitrates exert their actions via NO donation. Nitrates 52-60 nitric oxide synthase 2 Homo sapiens 85-87 9759915-3 1998 In this study, the effect of activation P2Z/P2X7 receptor was investigated on the bacterial lipopolysaccharide induced nitric oxide production in RAW 264.7 macrophage call line using the nitrite/nitrate assay. Nitrates 195-202 purinergic receptor P2X, ligand-gated ion channel, 7 Mus musculus 44-57 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 88-91 9715532-6 1998 Induction of GmNRT2 mRNA levels in roots occurred within 1 h after exposure of plants to nitrate. Nitrates 89-96 NRT2 protein Glycine max 13-19 9715532-7 1998 Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate. Nitrates 0-7 NRT2 protein Glycine max 21-27 9715532-7 1998 Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate. Nitrates 86-93 NRT2 protein Glycine max 21-27 9715532-7 1998 Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate. Nitrates 141-148 NRT2 protein Glycine max 21-27 9715532-8 1998 The molecular and physiological evidence indicates that GmNRT2 is probably a high-affinity nitrate transporter involved in nitrate uptake by soybean roots. Nitrates 91-98 NRT2 protein Glycine max 56-62 9759949-8 1998 RESULTS: In all of seven specimens from children with increased levels of nitrate/nitrite in the urine, we detected antibodies to iNOS, whereas in five of six control specimens--that is, from children with normal nitrate/nitrite levels--we could not detect any iNOS. Nitrates 74-81 nitric oxide synthase 2 Homo sapiens 130-134 9698594-9 1998 Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3-), a surrogate marker of ONOO- formation, in IL-1beta-stimulated cells. Nitrates 160-167 interleukin 1 beta Rattus norvegicus 218-226 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrates 72-79 interferon alpha 1 Homo sapiens 128-131 9865496-5 1998 Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6. Nitrates 72-79 interleukin 6 Homo sapiens 136-140 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrates 210-217 tumor necrosis factor Homo sapiens 37-64 9675176-3 1998 Activated macrophages synthesize NO, which is oxidized in the culture medium by molecular oxygen and superoxide (O2-, also released by the cells), yielding mainly nitrite (NO2-) and nitrate (NO3-) as the respective end products. Nitrates 182-189 NBL1, DAN family BMP antagonist Homo sapiens 191-194 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrates 210-217 interferon gamma Homo sapiens 66-75 9716178-3 1998 In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants. Nitrates 210-217 interleukin 1 beta Homo sapiens 81-98 9688317-4 1998 Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts. Nitrates 231-238 myelin basic protein Rattus norvegicus 28-48 9688317-4 1998 Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts. Nitrates 231-238 myelin basic protein Rattus norvegicus 50-53 9691115-4 1998 Maximal second order binding rates between 40,000 and 80,000 (m-1 x sec-1) were obtained for chlorides and nitrates of 1a group alkali ions with the exception of lithium supporting only rates of maximally 10,000 (M-1 x sec-1). Nitrates 107-115 myoregulin Homo sapiens 62-65 9708463-1 1998 OBJECTIVES: We sought to assess whether oxidation products of nitric oxide (NO), nitrite (NO2-) and nitrate (NO3-), referred to as NOx, are released by the heart of patients after acute myocardial infarction (AMI) and whether NOx can be determined in peripheral blood of these patients. Nitrates 100-107 NBL1, DAN family BMP antagonist Homo sapiens 109-112 9691115-4 1998 Maximal second order binding rates between 40,000 and 80,000 (m-1 x sec-1) were obtained for chlorides and nitrates of 1a group alkali ions with the exception of lithium supporting only rates of maximally 10,000 (M-1 x sec-1). Nitrates 107-115 secretory blood group 1, pseudogene Homo sapiens 68-73 9673545-5 1998 We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level. Nitrates 241-248 nitric oxide synthase 2 Homo sapiens 31-52 9673545-5 1998 We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level. Nitrates 241-248 nitric oxide synthase 2 Homo sapiens 54-58 9671763-5 1998 We report here that untreated p53 KO mice excreted 70% more nitrite plus nitrate than mice with wild-type (wt) p53. Nitrates 73-80 transformation related protein 53, pseudogene Mus musculus 30-33 9668089-10 1998 5-CHO-THF influx was restored by addition of chloride, fluoride, or nitrate but not by sulfate, phosphate, or ATP which were all inhibitory over a broad range of concentrations. Nitrates 68-75 thin fur Mus musculus 6-9 9671763-7 1998 Upon treatment with heat-inactivated Corynebacterium parvum, urinary nitrite plus nitrate excretion of p53 KO mice exceeded that of wt controls by approximately 200%. Nitrates 82-89 transformation related protein 53, pseudogene Mus musculus 103-106 9655731-2 1998 It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3). Nitrates 88-95 nitric oxide synthase 2 Homo sapiens 18-39 9655731-2 1998 It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3). Nitrates 88-95 NBL1, DAN family BMP antagonist Homo sapiens 101-104 9694586-5 1998 This procedure, supplemented with deproteinization and reduction of nitrates to nitrites in the presence of NADPH-sensitive reductase, can be successfully applied for measurement of NOx levels in human body fluids (serum, urine and CSF). Nitrates 68-76 colony stimulating factor 2 Homo sapiens 232-235 9639597-0 1998 Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions. Nitrates 86-93 arginine deiminase Escherichia coli 35-39 9639597-4 1998 In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway. Nitrates 102-109 arginine deiminase Escherichia coli 6-10 9639597-4 1998 In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway. Nitrates 102-109 arginine deiminase Escherichia coli 58-62 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrates 49-56 glutamic pyruvic transaminase, soluble Mus musculus 29-32 9662428-1 1998 We examined cytokinin and nitrate responsiveness in gene expression of five distinct response regulator homologs (ARR3-ARR7) in the leaves of nitrogen-starved Arabidopsis plants. Nitrates 26-33 response regulator 3 Arabidopsis thaliana 114-118 9662428-1 1998 We examined cytokinin and nitrate responsiveness in gene expression of five distinct response regulator homologs (ARR3-ARR7) in the leaves of nitrogen-starved Arabidopsis plants. Nitrates 26-33 response regulator 7 Arabidopsis thaliana 119-123 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrates 49-56 glutamic pyruvic transaminase, soluble Mus musculus 151-154 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrates 172-179 glutamic pyruvic transaminase, soluble Mus musculus 29-32 9625727-3 1998 Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P < 0.05). Nitrates 172-179 glutamic pyruvic transaminase, soluble Mus musculus 151-154 9573546-7 1998 Kallikrein gene delivery caused a decrease in blood urea nitrogen levels and increases in urinary kinin and nitrite/nitrate levels. Nitrates 116-123 kallikrein related peptidase 4 Homo sapiens 0-10 9631803-10 1998 IL-10 levels correlated with IL-6 levels (days 1 and 2) and nitrite+nitrate levels (days 1 and 3; p<0.05). Nitrates 68-75 interleukin 10 Homo sapiens 0-5 9607316-0 1998 Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. Nitrates 51-59 xanthine dehydrogenase Homo sapiens 0-23 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrates 81-88 xanthine dehydrogenase Homo sapiens 0-23 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrates 81-88 xanthine dehydrogenase Homo sapiens 25-28 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrates 117-124 xanthine dehydrogenase Homo sapiens 0-23 9607316-1 1998 Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH. Nitrates 117-124 xanthine dehydrogenase Homo sapiens 25-28 9626580-5 1998 This Lb-NO species, which has not been previously detected in intact root nodules of plants grown in the absence of nitrate, is thought to be formed by reaction of nitric oxide with iron(II) leghemoglobin. Nitrates 116-123 leghemoglobin A Glycine max 5-7 9617881-2 1998 Here we report for the first time that 1400W, a novel and highly selective inhibitor of iNOS activity, attenuates the delayed hypotension as well as the rise in the plasma levels of nitrite/nitrate caused by endotoxin in the rat. Nitrates 190-197 nitric oxide synthase 2 Rattus norvegicus 88-92 9626903-0 1998 Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure. Nitrates 66-73 angiotensin I converting enzyme Homo sapiens 22-51 9648741-1 1998 Two new nitrate assimilation-related genes, Nrt2;3 and Nar5, have been identified in Chlamydomonas reinhardtii. Nitrates 8-15 uncharacterized protein Chlamydomonas reinhardtii 55-59 9648741-3 1998 Like that of the nitrate assimilation genes, expression of the Nrt2;3 gene is down-regulated by ammonium and positively controlled by Nit2, a regulatory locus specific for the pathway. Nitrates 17-24 uncharacterized protein Chlamydomonas reinhardtii 134-138 9648741-8 1998 The Nrt2;3 and Nar5 genes are overexpressed in a deletion mutant that lacks nitrate assimilation loci. Nitrates 76-83 uncharacterized protein Chlamydomonas reinhardtii 15-19 9628026-6 1998 In whole plants, ZmCip1 transcript was transiently accumulated exclusively in leaves by supply of nitrate or ammonium ions to the roots, whereas the transcript was not accumulated in detached leaves by supply of the nitrogen nutrients. Nitrates 98-105 cytokinin response regulator 1 Zea mays 17-23 9628026-7 1998 Both the cytokinin- and nitrate-responsive accumulations of ZmCip1 transcript were accompanied by an increase in the immunotitratable protein. Nitrates 24-31 cytokinin response regulator 1 Zea mays 60-66 9667074-3 1998 A good positive correlation between either serum or gastric mucosal nitrite/nitrate concentration and gastric mucosal iNOS activity in all rats used (r = 0.741 or 0.842, respectively, p < 0.001) was found. Nitrates 76-83 nitric oxide synthase 2 Rattus norvegicus 118-122 9617881-4 1998 Similarly, administration of another selective inhibitor of iNOS activity, L-NIL, 2 h after endotoxin injection abolished the rise in nitrite/nitrate and attenuated the delayed hypotension caused by endotoxin, but failed to ameliorate organ injury. Nitrates 142-149 nitric oxide synthase 2 Rattus norvegicus 60-64 9661284-4 1998 Cd2+ (20 microM) stimulated an extensive swelling of nonenergized mitochondria incubated in 125 mM nitrate media, the effect being increased in the series of Li < Na < K < NH4. Nitrates 99-106 Cd2 molecule Rattus norvegicus 0-3 9523847-9 1998 A significant decrease in nitrate from preoperative levels in groups A (postoperative day (POD) 1 and 3; p < 0.0005) and B (POD 1, p < 0.0001) was observed; nitrate levels in group C did not decrease for 14 days after surgery. Nitrates 26-33 coronin 7 Homo sapiens 72-103 9495884-4 1998 Induction of iNOS protein is inferred because urinary nitrate and cGMP levels are increased 4 hr after LPS intravesical instillation and remain elevated for at least 24 hr. Nitrates 54-61 nitric oxide synthase 2 Rattus norvegicus 13-17 9466545-2 1998 Doxycycline (at 1.5 mg/kg) exerted its protective effect by inhibiting nitrate production by an interleukin-10-independent mechanism. Nitrates 71-78 interleukin 10 Mus musculus 96-110 9475262-6 1998 Increases in renin activity amounted to 130% (p < 0.001), 117% (p < 0.001), and 112% (p < 0.001) with molsidomine, and to 14, 16%, and 0 (each NS) with the nitrate at the corresponding times. Nitrates 165-172 renin Homo sapiens 13-18 9532589-5 1998 Nitrate and nitrite, were raised in the CSF and serum of patients with multiple sclerosis and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P < 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively). Nitrates 0-7 colony stimulating factor 2 Homo sapiens 40-43 9514534-9 1998 Endotoxin and interleukin-6 levels increased in a similar manner to nitrate levels, but tumor necrosis factor-alpha and interleukin-1 beta levels did not. Nitrates 68-75 interleukin 6 Homo sapiens 14-27 9532589-6 1998 CSF nitrate and nitrite levels correlated with the albumin quotient (n = 59, r = 0.42, P < 0.001). Nitrates 4-11 colony stimulating factor 2 Homo sapiens 0-3 9458730-4 1998 NO production, measured by the accumulation of nitrite and nitrate, was enhanced by 10(-7) M ANG II. Nitrates 59-66 angiotensinogen Rattus norvegicus 93-99 9526673-2 1998 The levels of nitrite (NO2-) and nitrate (NO3-) were measured simultaneously by high-performance liquid chromatography (HPLC) with UV detection using the Griess reaction after the reduction of nitrate to nitrite. Nitrates 33-40 NBL1, DAN family BMP antagonist Homo sapiens 42-45 9538982-13 1998 Resistance to nitrates, therefore, could be considered another feature of the insulin-resistance syndrome. Nitrates 14-22 insulin Homo sapiens 78-85 10684481-2 1998 When nitrates are metabolized to release NO, there is a considerable coproduction of reactive oxygen species (superoxide radical and peroxynitrite) in vessels leading to inactivation of NO, to diminished cyclic quanosine monophosphate production in smooth muscle cells (SMC), to impaired vasomotor responses to the endothelium-derived relaxation factor (EDRF), and to formation of nitrotyrosine as a marker of glyceryltrinitrate (GTN)-induced formation of peroxynitrite. Nitrates 5-13 alpha hemoglobin stabilizing protein Homo sapiens 315-352 9453315-8 1998 Tissue slices of the renal cortex and medulla were studied to determine the effects of Ang II and L-NAME on the nitrite/nitrate production. Nitrates 120-127 angiotensinogen Rattus norvegicus 87-93 9453315-9 1998 Ang II stimulated the nitrite/nitrate production predominately in the renal medulla, which was significantly attenuated by L-NAME. Nitrates 30-37 angiotensinogen Rattus norvegicus 0-6 9456273-2 1998 Up to 8 h after dosing in the morning, more marked and sustained effects were observed with the nitrate (ST at 2 h, -82%; p < 0.001; at 8 h, -64%; p < 0.01) than with molsidomine (2 h, -68%; p < 0.001; at 8 h, -9%; NS). Nitrates 96-103 signal transducer and activator of transcription 2 Homo sapiens 105-112 10684481-2 1998 When nitrates are metabolized to release NO, there is a considerable coproduction of reactive oxygen species (superoxide radical and peroxynitrite) in vessels leading to inactivation of NO, to diminished cyclic quanosine monophosphate production in smooth muscle cells (SMC), to impaired vasomotor responses to the endothelium-derived relaxation factor (EDRF), and to formation of nitrotyrosine as a marker of glyceryltrinitrate (GTN)-induced formation of peroxynitrite. Nitrates 5-13 alpha hemoglobin stabilizing protein Homo sapiens 354-358 9706250-9 1998 We conclude: 1) in addition to decreased granularity in atrial myocardiocytes, high circulating values of ANF here described suggest an increased turnover of the peptide in 2K2C hypertensive rats; 2) lower significant vascular relaxant effects in HT rats would indicate down regulation of ANF receptors in this model; the latter would derive from high plasma ANF concentration and, tentatively, because of greater activity of protein kinase C in the vascular wall; 39 similar values of plasma nitrite/nitrate in SH and HT rats would indicate a comparable NO circulating availability in both groups. Nitrates 501-508 natriuretic peptide A Rattus norvegicus 106-109 16793713-1 1998 Limited information seems to be available about the role of reduced endothelial production of endotheliumderived relaxing factor (EDRF)-nitrate/nitrite (NO) in the pathogenesis of diabetic angiopathy in insulindependent diabetes. Nitrates 136-143 alpha hemoglobin stabilizing protein Homo sapiens 94-128 9851362-5 1998 In addition, the above-mentioned changes in iNOS activity and LPO and NP-SH concentrations with lesion development in the gastric mucosa of rats with WIR stress were attenuated with both prevention of the lesion development and an increase in the concentration of gastric mucosal nitrite/nitrate, the breakdown products of NO, by pretreatment with aminoguanidine, a selective iNOS inhibitor. Nitrates 288-295 nitric oxide synthase 2 Rattus norvegicus 44-48 16793713-1 1998 Limited information seems to be available about the role of reduced endothelial production of endotheliumderived relaxing factor (EDRF)-nitrate/nitrite (NO) in the pathogenesis of diabetic angiopathy in insulindependent diabetes. Nitrates 136-143 alpha hemoglobin stabilizing protein Homo sapiens 130-134 16793713-5 1998 A significant and inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented. Nitrates 41-48 thrombomodulin Homo sapiens 124-138 9455975-0 1997 Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 37-40 9505412-1 1997 Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans. Nitrates 32-39 hemoglobin subunit gamma 2 Homo sapiens 80-93 9437522-4 1997 Intermediate 5, or the secondary products derived from it, decays to give NO3- and regenerated aldehyde, with small but significant yields of H2O2, organic acids, and organic nitrates. Nitrates 175-183 NBL1, DAN family BMP antagonist Homo sapiens 74-77 9326589-4 1997 CooA is a member of a family of transcriptional regulators similar to the cAMP receptor protein and fumavate nitrate reduction from Escherichia coli. Nitrates 109-116 CS1 fimbrial subunit A precursor Escherichia coli 0-4 9421934-8 1997 Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT. Nitrates 78-85 ferredoxin-dependent glutamate synthase, Fd-GOGAT Hordeum vulgare 113-121 9421934-8 1997 Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT. Nitrates 78-85 ferredoxin-dependent glutamate synthase, Fd-GOGAT Hordeum vulgare 147-155 9421934-8 1997 Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT. Nitrates 78-85 ferredoxin-dependent glutamate synthase, Fd-GOGAT Hordeum vulgare 147-155 9366711-9 1997 Nitrite and nitrate levels of the liver, ileum, and blood were higher in the iNOS+/+ mice (P < .05). Nitrates 12-19 nitric oxide synthase 2, inducible Mus musculus 77-81 9337353-0 1997 Nitrate plasma level as a marker of nitric oxide production after subcutaneous interleukin 2 immunotherapy. Nitrates 0-7 interleukin 2 Homo sapiens 79-92 9312089-5 1997 ATPase activity was strictly dependent on the presence of Na+ or Li+ ions and was inhibited by nitrate, N-ethylmaleimide, and the peptide antibiotic destruxin B. Nitrates 95-102 ATPase Enterococcus faecalis 0-6 9378986-6 1997 The PDTC concentration-dependent reductions in iNOS activity produced similar decreases in plasma nitrite/nitrate concentrations. Nitrates 106-113 nitric oxide synthase 2 Rattus norvegicus 47-51 9312089-6 1997 When the purified ATPase was reconstituted into liposomes prepared from Enterococcus faecalis phospholipids, ATP-driven Na+ uptake was observed; uptake was blocked by nitrate, destruxin B, and monensin, but it accelerated by carbonyl cyanide m-chlorophenylhydrazone and valinomycin. Nitrates 167-174 ATPase Enterococcus faecalis 18-24 9357468-4 1997 We therefore examined whether the plasma levels of nitrite (NO2-) and nitrate (NO3-) ions increased after arterial reconstruction in patients with arteriosclerosis obliterans (ASO). Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 79-82 9402285-3 1997 Both follicular nitrite (r = 0.42, P < 0.01) and nitrate (r = 0.49, P < 0.001) were found to be significantly correlated with follicular IL-1beta concentrations. Nitrates 52-59 interleukin 1 beta Homo sapiens 143-151 9402285-5 1997 When follicular cells were incubated in vitro with 10 ng/ml of IL-1beta for 24 h, nitrate generation was significantly (P < 0.01) elevated compared with the control. Nitrates 82-89 interleukin 1 beta Homo sapiens 63-71 21639276-6 1997 The tip diameter was down to 20 mum, and the sensors exhibited perfectly linear responses to nitrate in both freshwater and seawater. Nitrates 93-100 latexin Homo sapiens 32-35 9314409-8 1997 Human eNOS gene delivery induces significant increases in urinary and aortic cGMP levels and urinary and serum nitrite/nitrate content (P<.05), while no significant differences in body weight, heart rate, water intake, food consumption, or urine excretion were observed. Nitrates 119-126 nitric oxide synthase 3 Homo sapiens 6-10 9295837-1 1997 OBJECTIVES: To examine the relationship between circulating methemoglobin and nitrite/nitrate concentrations and to compare these markers of nitric oxide overproduction with clinical variables in children diagnosed with septic shock. Nitrates 86-93 hemoglobin subunit gamma 2 Homo sapiens 60-73 9316879-3 1997 We found that chronic proteasome inhibition using MG-341 significantly attenuated the peptidoglycan/polysaccharide (PG/PS)-induced up-regulation of iNOS in the colon and spleen and the consequent increase in plasma levels of nitrate and nitrite. Nitrates 225-232 nitric oxide synthase 2 Homo sapiens 148-152 9242548-5 1997 The NO release from iNOS-transfected cells, as measured by nitrite and nitrate accumulation and by cyclic guanosine monophosphate (cGMP) increases in rat reporter cells, was inhibitable (P < .01 for both) with N(omega)-methyl-L-arginine (L-NMA), a NOS inhibitor. Nitrates 71-78 nitric oxide synthase 2 Rattus norvegicus 20-24 9452775-8 1997 In the case of contraindication or impossibility of using angiotensin converting enzyme inhibitors, a combination of high doses of nitrates and hydralazine may be justified. Nitrates 131-139 angiotensin I converting enzyme Homo sapiens 58-87 9242464-5 1997 Inhibition of iNOS in vivo was confirmed by decreases in plasma nitrite + nitrate concentrations in treated animals compared with that of controls (63-83% decreases for all experiments) and was supported by plasma and tumor concentrations of 1400W that were equivalent and 2.6-4.9 times higher than the EC50 previously reported for iNOS in a tissue assay. Nitrates 74-81 nitric oxide synthase 2, inducible Mus musculus 14-18 9252519-4 1997 Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM. Nitrates 89-96 interleukin 1 beta Homo sapiens 29-69 9452775-9 1997 On the other hand, when angiotensin converting enzyme inhibitors are already prescribed, nitrates can only be considered to improve symptoms in the case of persistence of dyspnoea. Nitrates 89-97 angiotensin I converting enzyme Homo sapiens 24-53 9201027-6 1997 Production of NO metabolites (nitrate and nitrite), measured as their coronary arteriovenous differencexCBF, was significantly increased after 1 to 2 days of CAR, both at baseline (153 +/- 56%) and during BK infusion (220 +/- 76%) (P < .05). Nitrates 30-37 kininogen 1 Canis lupus familiaris 205-207 12223754-4 1997 SS mRNA was greatly reduced in nodules of drought-, salt-, and nitrate-treated plants; however, this was not correlated with changes in soluble carbohydrate, starch, amino acids, or ureides. Nitrates 63-70 sucrose synthase Glycine max 0-2 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrates 103-110 tumor necrosis factor Rattus norvegicus 130-157 9227507-6 1997 In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma. Nitrates 103-110 interferon gamma Rattus norvegicus 183-199 9193097-0 1997 A nitrate-inducible ferredoxin in maize roots. Nitrates 2-9 ferredoxin Zea mays 20-30 12223730-3 1997 The induction of nitrate reductase (NR) activity was reduced at both external nitrate concentrations. Nitrates 17-24 nitrate reductase [NADH] 1 Zea mays 36-38 9193097-2 1997 We have identified and characterized a nitrate-inducible ferredoxin (Fd) in maize (Zea mays L.) roots by structural analysis of the purified protein and by cloning of its cDNA and gene. Nitrates 39-46 ferredoxin Zea mays 57-67 9193097-2 1997 We have identified and characterized a nitrate-inducible ferredoxin (Fd) in maize (Zea mays L.) roots by structural analysis of the purified protein and by cloning of its cDNA and gene. Nitrates 39-46 ferredoxin Zea mays 69-71 9193097-3 1997 In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date. Nitrates 73-80 ferredoxin Zea mays 9-11 9193097-3 1997 In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date. Nitrates 73-80 ferredoxin Zea mays 91-93 9193097-3 1997 In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date. Nitrates 73-80 ferredoxin-6, chloroplastic Zea mays 143-148 9193097-3 1997 In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date. Nitrates 73-80 ferredoxin Zea mays 91-93 9193097-3 1997 In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date. Nitrates 73-80 ferredoxin Zea mays 91-93 9193097-5 1997 However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase. Nitrates 50-57 ferredoxin-6, chloroplastic Zea mays 86-91 9193097-5 1997 However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase. Nitrates 50-57 ferredoxin-6, chloroplastic Zea mays 166-171 9193097-5 1997 However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase. Nitrates 50-57 ferredoxin--nitrite reductase, chloroplastic Zea mays 271-288 9193097-8 1997 These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids. Nitrates 99-106 ferredoxin-6, chloroplastic Zea mays 25-30 9193097-8 1997 These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids. Nitrates 99-106 ferredoxin Zea mays 25-27 9193097-8 1997 These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids. Nitrates 99-106 ferredoxin Zea mays 153-155 9193097-8 1997 These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids. Nitrates 99-106 ferredoxin--nitrite reductase, chloroplastic Zea mays 281-298 9193097-8 1997 These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids. Nitrates 99-106 ferredoxin Zea mays 153-155 9211013-2 1997 Additional efficacy stems from the ability of the nitrates to replenish the deficient endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in patients with coronary heart disease and also to inhibit platelet aggregation. Nitrates 50-58 alpha hemoglobin stabilizing protein Homo sapiens 86-121 9146896-16 1997 Similarly, segments of rat aorta released detectable levels of nitrite and nitrate, which were reduced by NG-nitro-L-arginine methyl ester (L-NAME, 1 mM), which inhibits all isoforms of NOS, and by dexamethasone (1 microM), which inhibits the induction of iNOS. Nitrates 75-82 nitric oxide synthase 2 Rattus norvegicus 256-260 9211013-2 1997 Additional efficacy stems from the ability of the nitrates to replenish the deficient endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in patients with coronary heart disease and also to inhibit platelet aggregation. Nitrates 50-58 alpha hemoglobin stabilizing protein Homo sapiens 123-127 9211013-12 1997 However, in the GISSI 3 study, the combination of nitrates with an angiotensin-converting enzyme (ACE) inhibitor reduced mortality risks by 17% in patients with acute myocardial infarction. Nitrates 50-58 angiotensin I converting enzyme Homo sapiens 98-101 9133470-4 1997 iNOS expression in allografts resulted in elevated serum nitrite/nitrate levels, indicative of increased in vivo nitric oxide (NO) production. Nitrates 65-72 nitric oxide synthase 2 Rattus norvegicus 0-4 9136006-1 1997 In Chlamydomonas reinhardtii, the genes required for nitrate assimilation, including the gene encoding nitrate reductase (NIT1), are subject to repression by ammonia. Nitrates 53-60 uncharacterized protein Chlamydomonas reinhardtii 103-120 9136006-1 1997 In Chlamydomonas reinhardtii, the genes required for nitrate assimilation, including the gene encoding nitrate reductase (NIT1), are subject to repression by ammonia. Nitrates 53-60 uncharacterized protein Chlamydomonas reinhardtii 122-126 12237366-6 1997 After adding 12 mM nitrate to nitrate-limited Nia30(145), the transcripts for NR and phosphoenolpyruvate carboxylase increased, and the transcripts for ADP-glucose pyrophosphorylase decreased within 2 and 4 hr, respectively. Nitrates 19-26 phosphoenolpyruvate carboxylase Nicotiana tabacum 85-116 12237366-6 1997 After adding 12 mM nitrate to nitrate-limited Nia30(145), the transcripts for NR and phosphoenolpyruvate carboxylase increased, and the transcripts for ADP-glucose pyrophosphorylase decreased within 2 and 4 hr, respectively. Nitrates 30-37 phosphoenolpyruvate carboxylase Nicotiana tabacum 85-116 9133470-8 1997 CONCLUSIONS: (1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. Nitrates 472-479 nitric oxide synthase 2 Rattus norvegicus 17-21 9114772-0 1997 The alpha-1 adrenergic blocking agent urapidil counteracts postrotational atherectomy "elastic recoil" where nitrates have failed. Nitrates 109-117 adrenoceptor alpha 1D Homo sapiens 4-11 9168158-5 1997 A protein-mediated passive transport of nitrate was first demonstrated by the ability of NO3- to electrically short-circuit the (H+)ATPase in plasma membrane vesicles and not in liposomes containing only the purified enzyme. Nitrates 40-47 ATPase Zea mays 129-138 9281893-1 1997 A simple and sensitive HPLC validated method was developed for the simultaneous determination of ITF 296 (a new orally active nitrate) and its metabolites ITF 1124 and ITF 1577 in biological samples. Nitrates 126-133 trefoil factor 3 Homo sapiens 97-100 9175238-7 1997 An inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented in NIDDM, this correlation was much stronger in IDDM. Nitrates 26-33 thrombomodulin Homo sapiens 109-123 9175238-8 1997 Moreover, in IDDM patients reduced nitrate/nitrite excretion was strongly associated with elevated plasmatic beta-thromboglobulin levels. Nitrates 35-42 pro-platelet basic protein Homo sapiens 109-129 9175238-10 1997 In IDDM the decreased nitrate/nitrite excretion may also lead to increased in vivo platelet activation, which suggests that the reduced amount of EDRF-NO might play a role in the pathogenesis of angiopathy in IDDM. Nitrates 22-29 alpha hemoglobin stabilizing protein Homo sapiens 146-150 9161026-1 1997 Higher plant nitrite reductase (NiR) is a monomeric chloroplastic protein catalysing the reduction of nitrite, the product of nitrate reduction, to ammonium. Nitrates 126-133 nitrite reductase 1 Arabidopsis thaliana 13-30 9161026-1 1997 Higher plant nitrite reductase (NiR) is a monomeric chloroplastic protein catalysing the reduction of nitrite, the product of nitrate reduction, to ammonium. Nitrates 126-133 nitrite reductase 1 Arabidopsis thaliana 32-35 9161026-5 1997 When these plants were grown in vitro on media containing either nitrate or ammonium as sole nitrogen source, NiR mRNA derived from transgene expression was constitutively expressed, whereas NiR activity and protein level were strongly reduced on ammonium-containing medium. Nitrates 65-72 nitrite reductase 1 Arabidopsis thaliana 110-113 9161026-5 1997 When these plants were grown in vitro on media containing either nitrate or ammonium as sole nitrogen source, NiR mRNA derived from transgene expression was constitutively expressed, whereas NiR activity and protein level were strongly reduced on ammonium-containing medium. Nitrates 65-72 nitrite reductase 1 Arabidopsis thaliana 191-194 9093135-4 1997 NO is an unstable compound with a short half-life;it is easily converted to nitrite (NO2) and nitrate (NO3). Nitrates 94-101 NBL1, DAN family BMP antagonist Homo sapiens 103-106 9110418-5 1997 Similarly, LPS-induced production of nitrite/nitrate (breakdown products of nitric oxide) was not affected by verapamil and diltiazem. Nitrates 45-52 toll-like receptor 4 Mus musculus 11-14 9065390-4 1997 The transformants carrying nit1/ars did not express arylsulphatase when grown in ammonium-sufficient medium but readily accumulated the enzyme in ammonium-free medium either supplemented, or not supplemented, with nitrate or nitrite. Nitrates 214-221 uncharacterized protein Chlamydomonas reinhardtii 27-31 9023196-0 1997 Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1. Nitrates 122-129 cytochrome c Shewanella oneidensis MR-1 24-28 9087877-7 1997 CONCLUSIONS: These results, together with our previous demonstration that iNOS inhibition ameliorated lung allograft rejection, suggest that (1) iNOS expression and increased NO production contributed to acute rejection of the transplanted lung, (2) iNOS inhibition may offer an alternative in management of acute lung allograft rejection, and (3) increased NO production, detected by the presence of iNOS mRNA or protein or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection. Nitrates 466-473 nitric oxide synthase 2 Rattus norvegicus 74-78 9085575-2 1997 We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484). Nitrates 113-120 NPK1-related protein kinase 1 Arabidopsis thaliana 89-92 9085575-2 1997 We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484). Nitrates 113-120 NPK1-related protein kinase 2 Arabidopsis thaliana 97-100 9085575-2 1997 We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484). Nitrates 113-120 nitrate reductase 1 Arabidopsis thaliana 137-140 9085575-2 1997 We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484). Nitrates 113-120 nitrate reductase 2 Arabidopsis thaliana 145-148 9085575-3 1997 Here we identify the cis-acting elements of NP1 and NP2 that are necessary for nitrate-dependent transcription by linker-scanning (LS) analysis. Nitrates 79-86 NPK1-related protein kinase 1 Arabidopsis thaliana 44-47 9085575-3 1997 Here we identify the cis-acting elements of NP1 and NP2 that are necessary for nitrate-dependent transcription by linker-scanning (LS) analysis. Nitrates 79-86 NPK1-related protein kinase 2 Arabidopsis thaliana 52-55 9085575-4 1997 In transgenic plants one LS mutant of NP1 and two LS mutants of NP2 exhibited significantly lower nitrate-induced reporter gene chloramphenicol acetyltransferase activity. Nitrates 98-105 NPK1-related protein kinase 1 Arabidopsis thaliana 38-41 9085575-4 1997 In transgenic plants one LS mutant of NP1 and two LS mutants of NP2 exhibited significantly lower nitrate-induced reporter gene chloramphenicol acetyltransferase activity. Nitrates 98-105 NPK1-related protein kinase 2 Arabidopsis thaliana 64-67 9085575-6 1997 The single LS mutant in NP1 lost its response to nitrate, whereas the two LS mutants in NP2 partially lost their response to nitrate. Nitrates 49-56 NPK1-related protein kinase 1 Arabidopsis thaliana 24-27 9085575-6 1997 The single LS mutant in NP1 lost its response to nitrate, whereas the two LS mutants in NP2 partially lost their response to nitrate. Nitrates 125-132 NPK1-related protein kinase 2 Arabidopsis thaliana 88-91 9071565-4 1997 Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII). Nitrates 6-13 interleukin 6 Homo sapiens 84-88 9071565-4 1997 Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII). Nitrates 6-13 C-X-C motif chemokine ligand 8 Homo sapiens 90-94 9071565-4 1997 Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII). Nitrates 6-13 tumor necrosis factor Homo sapiens 96-105 9071565-4 1997 Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII). Nitrates 6-13 interleukin 10 Homo sapiens 147-152 9023196-2 1997 This gene complemented a mutant which had a TnphoA insertion in cymA and which was deficient in the respiratory reduction of iron(III), nitrate, fumarate, and manganese(IV). Nitrates 136-143 cytochrome c Shewanella oneidensis MR-1 64-68 8994427-11 1997 CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation. Nitrates 148-156 fibrinogen beta chain Homo sapiens 192-202 9020872-0 1997 The YNT1 gene encoding the nitrate transporter in the yeast Hansenula polymorpha is clustered with genes YNI1 and YNR1 encoding nitrite reductase and nitrate reductase, and its disruption causes inability to grow in nitrate. Nitrates 27-34 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 4-8 9020872-2 1997 Disruption of the chromosomal YNT1 copy resulted in incapacity to grow in nitrate and a significant reduction in rate of nitrate uptake. Nitrates 74-81 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 30-34 9020872-2 1997 Disruption of the chromosomal YNT1 copy resulted in incapacity to grow in nitrate and a significant reduction in rate of nitrate uptake. Nitrates 121-128 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 30-34 9020872-4 1997 Northern-blot analysis showed that YNT1 is expressed when the yeast is grown in nitrate and nitrite but not in ammonium solution. Nitrates 80-87 proteasome regulatory particle base subunit RPT3 Saccharomyces cerevisiae S288C 35-39 8994427-11 1997 CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation. Nitrates 148-156 selectin P Homo sapiens 231-241 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrates 77-84 tumor necrosis factor Mus musculus 14-17 8995407-5 1997 The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries. Nitrates 91-98 mitochondrially encoded cytochrome c oxidase II Homo sapiens 181-187 9001323-6 1997 Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956). Nitrates 77-84 interleukin 1 complex Mus musculus 25-29 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrates 122-129 interferon gamma Homo sapiens 41-50 9503598-4 1997 The ranges of SCP under the influence of temperature, light, nitrate, ammonia, phosphorus, iron, carbonate, and sodium chloride were in the following respective order (% dry wt): 18.4-43.3, 20.5-42.3, 12.4-35.8, 15.7-41.8, 15.8-49.4, 17.4-49.7, 13.8-35.6, and 0.0-37.7. Nitrates 61-68 solute carrier family 50 member 1 Homo sapiens 14-17 8985206-8 1997 Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations. Nitrates 122-129 interleukin 4 Homo sapiens 51-55 9411502-4 1997 The mean +/- levels of nitrite and nitrate in CSF on admission were higher in patients with BM in comparison with controls and in children with viral meningitis. Nitrates 35-42 colony stimulating factor 2 Homo sapiens 46-49 9010412-0 1997 A rostrocaudal gradient of nitrate plus nitrite concentrations in CSF. Nitrates 27-34 colony stimulating factor 2 Homo sapiens 66-69 8981915-13 1996 Treatment with recombinant human growth hormone normalizes urinary nitrate and cyclic GMP excretion, possibly via IGF-1 stimulation of endothelial NO formation, and concomitantly decreases peripheral arterial resistance. Nitrates 67-74 growth hormone 1 Homo sapiens 33-47 9035296-8 1997 The plasma level of nitrate/nitrite increased from 20 to 260 and 1000 microM 4 and 16 h, respectively, 20 mg/kg NMLA abolished NO production at 4 h, while MP inhibited it for up to 16 h. The hepatic malondialdehyde level increased from 0.50 to 2.46 nmol/mg protein at 4 h. Administration of anti-CD18 and MP reduced the level to 1.80 and 1.41 nmol/mg protein, respectively, whereas NMLA did not affect it. Nitrates 20-27 integrin beta 2 Mus musculus 296-300 15336795-5 2004 Nitrate reduction was likely due to microbial degradation of accumulated organic matter coupled with successive consumption of O2 and NO3- in the macropore water followed by reductive dissolution of Fe and Mn from minerals along the macropores. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 134-137 8943494-1 1996 Nitric oxide (NO) is readily oxidized to nitrate and nitrite and NO activates guanylyl cyclase, increasing cyclic GMP levels. Nitrates 41-48 5'-nucleotidase, cytosolic II Homo sapiens 114-117 8989878-0 1996 CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots. Nitrates 45-52 nitrate transporter 1.1 Arabidopsis thaliana 0-4 8989878-1 1996 The Arabidopsis CHL1 (AtNRT1) gene confers sensitivity to the herbicide chlorate and encodes a nitrate-regulated nitrate transporter. Nitrates 95-102 nitrate transporter 1.1 Arabidopsis thaliana 16-20 8989878-1 1996 The Arabidopsis CHL1 (AtNRT1) gene confers sensitivity to the herbicide chlorate and encodes a nitrate-regulated nitrate transporter. Nitrates 95-102 nitrate transporter 1.1 Arabidopsis thaliana 22-28 8989878-2 1996 However, how CHL1 participates in nitrate uptake in plants is not yet clear. Nitrates 34-41 nitrate transporter 1.1 Arabidopsis thaliana 13-17 8989878-4 1996 Under most conditions tested, the amount of nitrate uptake by a chl1 deletion mutant was found to be significantly less than that of the wild type. Nitrates 44-51 nitrate transporter 1.1 Arabidopsis thaliana 64-68 8989878-7 1996 These results are consistent with the involvement of CHL1 in nitrate uptake at different stages of root cell development. Nitrates 61-68 nitrate transporter 1.1 Arabidopsis thaliana 53-57 8989878-8 1996 A functional analysis in Xenopus oocytes indicated that CHL1 is a low-affinity nitrate transporter with a K(m) value of approximately 8.5 mM for nitrate. Nitrates 79-86 DEAD/H-box helicase 11 L homeolog Xenopus laevis 56-60 8938409-5 1996 CYCD3 (delta 3) transcript levels were strongly dependent on nitrate, and were induced at the G1/S transition following phytohormone readdition. Nitrates 61-68 CYCLIN D3;1 Arabidopsis thaliana 0-5 8953249-4 1996 Transcripts for ZmSUMT1 accumulated rapidly in both rots and leaves in response to the addition of nitrate to the culture medium. Nitrates 99-106 siroheme uroporphyrinogen methyltransferase 1 Zea mays 16-23 8953249-5 1996 The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase. Nitrates 45-52 siroheme uroporphyrinogen methyltransferase 1 Zea mays 89-96 8883421-0 1996 Plasma nitrate plus nitrite changes during continuous intravenous infusion interleukin 2. Nitrates 7-14 interleukin 2 Homo sapiens 75-88 8953249-5 1996 The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase. Nitrates 45-52 nitrate reductase [NADH] 1 Zea mays 177-194 8953249-5 1996 The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase. Nitrates 45-52 ferredoxin--nitrite reductase, chloroplastic Zea mays 199-216 8953249-5 1996 The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase. Nitrates 147-154 siroheme uroporphyrinogen methyltransferase 1 Zea mays 89-96 8953249-7 1996 The results together indicate that ZmSUMT1 might be involved in the synthesis of siroheme, a prosthetic group of nitrite reductase, and that the expression of its gene is co-regulated with that of other nitrate-assimilatory genes. Nitrates 203-210 siroheme uroporphyrinogen methyltransferase 1 Zea mays 35-42 8937711-18 1996 in conscious unrestrained rats, 2-amino-4-methylpyridine inhibited the rise in plasma nitrate produced in response to intraperitoneal injection of LPS (ID50 = 0.009 mg kg-1 min-1). Nitrates 86-93 toll-like receptor 4 Mus musculus 147-150 8937711-23 1996 2-Amino-4-methylpyridine also inhibited LPS-induced elevation in plasma nitrate after either subcutaneous (ID50 = 0.3 mg kg-1) or oral (ID50 = 20.8 mg kg-1) administration. Nitrates 72-79 toll-like receptor 4 Mus musculus 40-43 8883421-12 1996 We conclude that determination of plasma nitrate + nitrite levels during CIVI IL-2 can usefully estimate, in a dose-dependent pattern, the degree of peripheral vascular relaxation and capillary leakage associated with cytokine action, clinically manifested as hypotension. Nitrates 41-48 interleukin 2 Homo sapiens 78-82 8864137-20 1996 Serum levels of tumor necrosis factor-alpha (TNF-alpha and nitrite/nitrate in IFN-gamma-treated mice were similar to those of controls. Nitrates 67-74 interferon gamma Mus musculus 78-87 9064335-6 1996 Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro. Nitrates 222-229 interferon gamma Homo sapiens 163-179 8906612-4 1996 In addition, the mutant SOD protein may function as a peroxidase to oxidize cellular components, and it may also react with peroxynitrite-a product of the reaction between superoxide and nitric oxide-to ultimately form nitrate proteins. Nitrates 219-226 superoxide dismutase 1 Homo sapiens 24-27 8884978-9 1996 On study admission and at 2-h intervals, plasma CGRP concentrations correlated directly with nitrite and nitrate values. Nitrates 105-112 calcitonin related polypeptide alpha Homo sapiens 48-52 8950496-14 1996 Patients taking nitrates had lower activation; after eliminating these patients, GPIIb/IIIa ligand binding was greater among patients with restenosis at both 1 and 2 min (P = 0.04 for both). Nitrates 16-24 integrin subunit alpha 2b Homo sapiens 81-86 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 TNF receptor superfamily member 1A Homo sapiens 216-219 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 TNF receptor superfamily member 1B Homo sapiens 224-227 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 interferon gamma Homo sapiens 307-323 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 interleukin 10 Homo sapiens 327-341 8912158-11 1996 After RY, nitrite/nitrate concentration increased to 22.7 +/- 30.1, 32.4 +/- 21.4 and 44.6 +/- 32.7 mol/l in RY1, RY2 and RY3, respectively; in RY45, serum nitrite/nitrate concentration was normal averaging 6.1 +/- 1.2 mol/l. Nitrates 18-25 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 Rattus norvegicus 109-112 8902940-5 1996 Selective inhibition of iNOS with mercaptoethylguanidine (MEG) reduced plasma nitrite/nitrate levels, but did not prevent the development of vascular hyporeactivity, and did not improve survival in this model of CLP. Nitrates 86-93 nitric oxide synthase 2 Rattus norvegicus 24-28 8806782-11 1996 However, ONOO., formed by the reaction of .NO and O2.-, nitrates SP-A leading to decreased ability to aggregate lipids and bind mannose. Nitrates 56-64 surfactant protein A1 Homo sapiens 65-69 8921069-2 1996 Our aim was to study follicular nitrite and nitrate (NO3/NO2) levels in women undergoing in-vitro fertilization (IVF), and to examine their relationship to follicular size, oestradiol concentrations, and ovarian artery and intra-ovarian blood flow as measured by Doppler ultrasound. Nitrates 44-51 NBL1, DAN family BMP antagonist Homo sapiens 53-56 8923042-3 1996 Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p > 0.05). Nitrates 33-40 tumor necrosis factor Homo sapiens 135-168 8702535-5 1996 Planar nitrate, NO3-, is isosteric with the PO3 moiety of a phosphotransfer transition state. Nitrates 7-14 NBL1, DAN family BMP antagonist Homo sapiens 16-19 8799195-1 1996 Two mutations have been found in a gene (NRT2) of Arabidopsis thaliana that specifically impair constitutive, high-affinity nitrate uptake. Nitrates 124-131 nitrate transporter 2:1 Arabidopsis thaliana 41-45 8799195-7 1996 These results indicate that NRT2 is a critical and perhaps necessary gene for constitutive, high-affinity nitrate uptake in Arabidopsis, but not for inducible, high-affinity nor constitutive, low-affinity nitrate uptake. Nitrates 106-113 nitrate transporter 2:1 Arabidopsis thaliana 28-32 9132576-1 1996 Health effects associated with ingestion of nitrate-contaminated water have included methemoglobinemia (i.e., blue baby syndrome) in infants and spontaneous abortions in laboratory animals and livestock; however, only one study in humans has reported an association between increased methemoglobin levels and spontaneous abortion. Nitrates 44-51 hemoglobin subunit gamma 2 Homo sapiens 85-98 8842573-9 1996 The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate. Nitrates 30-37 interleukin 1 receptor like 1 Homo sapiens 46-68 8694791-7 1996 In the presence of nitrate the delta ynil::URA3 mutant extrudes approx. Nitrates 19-26 orotidine-5'-phosphate decarboxylase Saccharomyces cerevisiae S288C 43-47 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 272-279 interleukin 1 beta Rattus norvegicus 66-84 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 272-279 tumor necrosis factor Rattus norvegicus 98-125 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 272-279 interferon gamma Rattus norvegicus 139-155 8760140-2 1996 Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-). Nitrates 272-279 interferon gamma Rattus norvegicus 157-166 8674325-8 1996 Children with increased plasma IL-6 concentrations (n = 6) had increased plasma nitrite/nitrate concentrations (p < 0.01 on each day), increased organ failure scores (p < .05 on days 1 and 3), and the highest plasma IL-10 concentrations (p < .05 on days 1 and 3, p = .054 on day 2) when compared with children with sepsis and undetectable IL-6 concentrations. Nitrates 88-95 interleukin 6 Homo sapiens 31-35 8674325-9 1996 Children with sepsis and detectable IL-6 concentrations, and children with undetectable IL-6 concentrations, both had increased nitrite/nitrate concentrations (p < .005 on days 1 through 3) and increased IL-10 concentrations (p < .05 on days 1 and 2) compared with controls. Nitrates 136-143 interleukin 6 Homo sapiens 88-92 8842573-9 1996 The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate. Nitrates 121-128 interleukin 1 receptor like 1 Homo sapiens 46-68 8842573-9 1996 The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate. Nitrates 121-128 interleukin 1 receptor like 1 Homo sapiens 46-68 8651088-1 1996 Nitrate tolerance has been reported to be reversed by certain types of angiotensin-converting enzyme (ACE) inhibitors. Nitrates 0-7 angiotensin I converting enzyme Homo sapiens 71-100 8844437-2 1996 It appears to relax vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and, like nitrates, through an increase in intracellular cyclic GMP. Nitrates 138-146 5'-nucleotidase, cytosolic II Homo sapiens 192-195 8651088-1 1996 Nitrate tolerance has been reported to be reversed by certain types of angiotensin-converting enzyme (ACE) inhibitors. Nitrates 0-7 angiotensin I converting enzyme Homo sapiens 102-105 8651088-8 1996 In conclusion, a single oral administration of the ACE inhibitor alacepril (50mg) elicited beneficial effects against exercise-induced myocardial ischemia in patients with stable effort angina during chronic nitrate treatment. Nitrates 208-215 angiotensin I converting enzyme Homo sapiens 51-54 8640982-0 1996 Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo. Nitrates 84-91 angiotensin I converting enzyme Homo sapiens 10-39 16535328-9 1996 The positive reaction to nitrate overruled a negative response to oxygen, indicating that nitrate is the principal electron acceptor used by Thioploca spp. Nitrates 25-32 histocompatibility minor 13 Homo sapiens 151-154 16535328-9 1996 The positive reaction to nitrate overruled a negative response to oxygen, indicating that nitrate is the principal electron acceptor used by Thioploca spp. Nitrates 90-97 histocompatibility minor 13 Homo sapiens 151-154 8689594-6 1996 Greenfeed often contains high levels of nitrate (NO3-), which is known to impair thyroid gland function. Nitrates 40-47 NBL1, DAN family BMP antagonist Homo sapiens 49-52 8640982-13 1996 The present study also favors a combination of nitroglycerin and ACE inhibitors to maintain nitrate sensitivity of the vasculature during long-term nitroglycerin treatment. Nitrates 92-99 angiotensin I converting enzyme Homo sapiens 65-68 8638526-7 1996 Recent information suggests that nitrate tolerance is caused by increased levels of superoxide at the vascular wall, which leads to reduced nitric oxide level and to increased sensitivity to vasoconstrictive mechanisms, such as endothelin and angiotensin II. Nitrates 33-40 angiotensinogen Homo sapiens 228-257 8854644-14 1996 Subcutaneous IL-2 treatment strongly induced nitric oxide synthesis (up to 3.5 mumoles of urinary nitrate/ mouse/day). Nitrates 98-105 interleukin 2 Mus musculus 13-17 8761850-7 1996 In both nitrate-tolerant and nontolerant coronary arteries, glibenclamide (GLI 10(-6) M), a selective KATP channel blocker, caused a parallel rightward shift in the concentration-response curve to cromakalim, but had no effect on responses to NTG or SNP. Nitrates 8-15 GLI family zinc finger 1 Homo sapiens 75-78 8761850-8 1996 In nontolerant coronary arteries, GLI had no effect on NIC-induced relaxation, but in nitrate-tolerant preparations, GLI produced a significant rightward shift in the NIC concentration-response curve. Nitrates 86-93 GLI family zinc finger 1 Homo sapiens 117-120 8928839-2 1996 The infusion of myoglobin (375 mg/kg) resulted in a decrease in renal blood flow, an increase in renal vascular resistance, and a decrease in creatine clearance associated with a decrease in urinary excretory rate of nitrite/nitrate and guanosine 3",5"-cyclic monophosphate (cGMP). Nitrates 225-232 LOW QUALITY PROTEIN: myoglobin Oryctolagus cuniculus 16-25 8804922-3 1996 Following injection of endotoxin (bacterial lipopolysaccharide) in rats we detected increased inducible NO synthase mRNA levels in the left ventricular wall within 30 min which then peaked at 3 h. This was followed by an increase in myocardial inducible NO synthase enzyme activity and plasma levels of NO metabolites, nitrate and nitrite, which peaked at 6 and 12 h, respectively. Nitrates 319-326 nitric oxide synthase 2 Rattus norvegicus 94-115 8620596-6 1996 iNOS mRNA was expressed in the allograft heart and native lung and was associated with increased serum nitrite/nitrate levels. Nitrates 111-118 nitric oxide synthase 2 Rattus norvegicus 0-4 16535314-5 1996 Nitrate inhibited As(V) reduction by its action as a preferred respiratory electron acceptor rather than as a structural analog of As(V). Nitrates 0-7 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 18-23 16535314-5 1996 Nitrate inhibited As(V) reduction by its action as a preferred respiratory electron acceptor rather than as a structural analog of As(V). Nitrates 0-7 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 131-136 16535314-6 1996 Nitrate-respiring sediments could reduce As(V) to As(III) once all the nitrate was removed. Nitrates 0-7 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 41-46 16535314-6 1996 Nitrate-respiring sediments could reduce As(V) to As(III) once all the nitrate was removed. Nitrates 71-78 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 41-46 16535314-7 1996 Chloramphenicol blocked the reduction of As(V) to As(III) in nitrate-respiring sediments, suggesting that nitrate and arsenate were reduced by separate enzyme systems. Nitrates 61-68 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 41-46 16535314-7 1996 Chloramphenicol blocked the reduction of As(V) to As(III) in nitrate-respiring sediments, suggesting that nitrate and arsenate were reduced by separate enzyme systems. Nitrates 106-113 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 41-46 8620596-7 1996 iNOS inhibition with aminoguanidine prevented or attenuated allograft heart and systemic vascular barrier dysfunction and reduced allograft serum nitrite/nitrate levels to isograft values. Nitrates 154-161 nitric oxide synthase 2 Rattus norvegicus 0-4 8630708-9 1996 ANP was higher in subjects with jugular venous pressure > 10 cm, presence of a third heart sound, peripheral edema, artificial cardiac pacemaker, atrial arrhythmias, and in those taking digoxin, diuretics, or nitrates. Nitrates 212-220 natriuretic peptide A Homo sapiens 0-3 8743440-0 1996 Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines. Nitrates 0-7 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 59-63 8743440-10 1996 In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Nitrates 79-86 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 158-162 8859948-1 1996 Whether the arterial elastic structures are involved in the beneficial effects of long-term treatment with organic nitrates on atherosclerosis-induced changes in hemodynamics and arterial wall viscoelastic properties, are case for angiotensin-converting enzyme (ACE) inhibitors, is not known. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 231-260 8859948-1 1996 Whether the arterial elastic structures are involved in the beneficial effects of long-term treatment with organic nitrates on atherosclerosis-induced changes in hemodynamics and arterial wall viscoelastic properties, are case for angiotensin-converting enzyme (ACE) inhibitors, is not known. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 262-265 8621213-3 1996 Therefore, we designed these studies to test the hypothesis that Ang II exerts time-dependent effects on renal NO generation as assessed from renal excretion of nitrate and nitrite, percent increases in renal vascular resistance during inhibition of NO synthase with intravenous NG -nitro-L-arginine methyl ester (L-NAME), or decreases in renal vascular resistance during stimulation of endothelial NO synthase with intravenous acetylcholine. Nitrates 161-168 angiotensinogen Rattus norvegicus 65-71 8621213-6 1996 The renal excretion of nitrate and nitrite was increased during short-term Ang II infusions (from 205 +/- 22 to 331 +/- 58 pmol.min-1, P < .05) but was unchanged during prolonged Ang II infusion (control group, 197 +/- 33 versus Ang II, 245 +/- 42 pmol.min-1, P=NS). Nitrates 23-30 angiotensinogen Rattus norvegicus 75-81 8630708-10 1996 On multivariate analysis independent predictors of ANP levels were, in descending order, nitrates, age, diuretics, and atrial arrhythmias. Nitrates 89-97 natriuretic peptide A Homo sapiens 51-54 8871401-2 1996 Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels. Nitrates 79-86 aconitase 1 Homo sapiens 145-186 8871401-2 1996 Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels. Nitrates 79-86 aconitase 1 Homo sapiens 188-192 12226271-0 1996 Appearance of Novel Glucose-6-Phosphate Dehydrogenase Isoforms in Chlamydomonas reinhardtii during Growth on Nitrate. Nitrates 109-116 uncharacterized protein Chlamydomonas reinhardtii 20-53 8627326-0 1996 Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo. Nitrates 48-55 nitric oxide synthase 2 Homo sapiens 76-97 8627326-1 1996 The ex vivo tissue concentration of nitrite and nitrate (NOx) was found to correlate closely with the activity of nitric oxide synthase (NOS; EC 1.14.13.39) in various brain regions. Nitrates 48-55 nitric oxide synthase 2 Homo sapiens 114-135 8731510-2 1996 We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates. Nitrates 458-466 insulin Homo sapiens 17-24 8731510-3 1996 On the contrary, at very elevated concentrations (25-200 nmol/L) insulin increases platelet aggregation to ADP (ADP ED50 with 200 nmol/L insulin being 81 +/- 4% of the basal value, p = 0.01), decreases intraplatelet content of cGMP (from basal 7.2 +/- 0.1 pmol/10(9) plts to 5.7 +/- 0.2 pmol/10(9) plts with 200 nmol/L insulin, p = 0.01) and attenuates the platelet cGMP increase induced by nitrates. Nitrates 391-399 insulin Homo sapiens 65-72 8661258-1 1996 Gd3+ is shown to be an effective shift reagent for 14N and 15N nitrate NMR signals, resolving the internal and external nitrate signals in plant tissues, including cell suspensions and root material. Nitrates 63-70 GRDX Homo sapiens 0-3 8661258-1 1996 Gd3+ is shown to be an effective shift reagent for 14N and 15N nitrate NMR signals, resolving the internal and external nitrate signals in plant tissues, including cell suspensions and root material. Nitrates 120-127 GRDX Homo sapiens 0-3 8661258-2 1996 However, time-course experiments show that, while the use of Gd3+ allows nitrate levels to be monitored over extended periods, it also has adverse effects on growth and nitrate uptake. Nitrates 73-80 GRDX Homo sapiens 61-64 8661258-2 1996 However, time-course experiments show that, while the use of Gd3+ allows nitrate levels to be monitored over extended periods, it also has adverse effects on growth and nitrate uptake. Nitrates 169-176 GRDX Homo sapiens 61-64 8904084-2 1996 Interleukin-1beta stimulated the production of nitrite and nitrate, stable metabolites of NO, in a dose- and time-dependent manner in vascular smooth muscle cells. Nitrates 59-66 interleukin 1 beta Rattus norvegicus 0-17 8628918-11 1996 Several cases of methemoglobinemia have been reported in infants in the United States using water containing nitrate at levels higher than the current maximum contaminant level (MCL) of 45 ppm (mg/liter) nitrate (NO3) or 10 ppm nitrate-nitrogen (nitrate-N), but none at or lower than the MCL. Nitrates 109-116 NBL1, DAN family BMP antagonist Homo sapiens 213-216 8741130-2 1996 Recently, it has been reported decreased CSF nitrate levels (oxidation product that provides an indirect estimation of nitric oxide) in Parkinson"s disease patients, assessed with a colorimetric method. Nitrates 45-52 colony stimulating factor 2 Homo sapiens 41-44 8741130-5 1996 They were not influenced significantly by antiparkinsonian drugs in patients, although there was a trend for CSF nitrate levels to be higher in patients treated with levodopa or with dopamine agonists. Nitrates 113-120 colony stimulating factor 2 Homo sapiens 109-112 8628918-11 1996 Several cases of methemoglobinemia have been reported in infants in the United States using water containing nitrate at levels higher than the current maximum contaminant level (MCL) of 45 ppm (mg/liter) nitrate (NO3) or 10 ppm nitrate-nitrogen (nitrate-N), but none at or lower than the MCL. Nitrates 204-211 NBL1, DAN family BMP antagonist Homo sapiens 213-216 8924591-13 1996 The most important variables, associated with both mutagenicity and Ah receptor affinity, included 1-nitropyrene, particle bound nitrate, indeno[1,2,3-cd]pyrene, and emitted mass of particles. Nitrates 129-136 aryl hydrocarbon receptor Homo sapiens 68-79 8647309-9 1996 The nitrate levels were in the range 1-2.6 mg/kg NO3- for fresh milk and 1.1-18 mg/kg NO3- for dry milk. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 49-52 8739090-1 1996 The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. Nitrates 31-38 NBL1, DAN family BMP antagonist Homo sapiens 40-43 8569419-3 1996 Thus we studied sex differences in NO-generation by measuring single breath NO-exhalation and plasma levels of nitrate (NO3), the stable endmetabolite of NO. Nitrates 111-118 NBL1, DAN family BMP antagonist Homo sapiens 120-123 8598489-0 1996 IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer. Nitrates 91-98 interleukin 1 beta Homo sapiens 0-9 8632501-1 1996 BACKGROUND: Hexogen (cyclonite, RDX) nitrate explosive is an infrequent cause of poisoning. Nitrates 37-44 radixin Homo sapiens 32-35 8754362-9 1996 For patients who cannot take an ACE inhibitor the combination of hydralazine and nitrates may offer some prognostic benefit. Nitrates 81-89 angiotensin I converting enzyme Homo sapiens 32-35 7489995-4 1995 Pretreatment of mice with IL-1 resulted in elevated levels of nitrite/nitrate in serum and in enhanced nitric oxide synthase (NOS) activity in liver cells isolated from these animals. Nitrates 70-77 interleukin 1 complex Mus musculus 26-30 8878363-3 1996 The chemical analysis of fog during 32 episodes of local fog (pH, chloride, nitrate, sulphate, sodium, ammonia, potassium, magnesium, calcium) has shown a greater concentration of pollutants and greater acidity in the smaller particles (2-6 microns) which are able to penetrate the bronchial tree. Nitrates 76-83 zinc finger protein, FOG family member 1 Homo sapiens 25-28 7594544-6 1995 Increased levels of nitrate (NO3-) were only detected in serum of resistant C57BL/6 mice at the time of peak parasitemia. Nitrates 20-27 NBL1, DAN family BMP antagonist Mus musculus 29-32 8616217-10 1995 The striking degree of conservation between the macrophage-specific mammalian Nramp and its OsNramp1 plant homologue is discussed with respect to possible implications in the metabolism of nitrate in both organisms. Nitrates 189-196 solute carrier family 11 member 1 Homo sapiens 78-83 7492033-10 1995 For the Indonesian dry (powdered) milk sample studied the nitrate levels were in the range 10.7-29.5 mg kg-1 NO3-. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 109-112 8597057-2 1995 Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Nitrates 91-98 interleukin 1 beta Mus musculus 26-44 8597057-2 1995 Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Nitrates 91-98 interleukin 1 complex Mus musculus 46-50 8534848-6 1995 They were designated as iNR1 and iNR2, respectively, since both were inducible by nitrate. Nitrates 82-89 inducible nitrate reductase [NADH] 1 Glycine max 24-28 7594598-18 1995 Subcutaneous IL-2 therapy increased urinary nitrate excretion up to eightfold in mice, and appeared to produce a significant survival advantage that was prevented by MLA administration. Nitrates 44-51 interleukin 2 Mus musculus 13-17 8747803-13 1995 N-acetylcysteine inhibits angiotensin converting enzyme and counteracts nitrate-induced stimulation of the renin angiotensin system in vivo. Nitrates 72-79 renin Homo sapiens 107-112 8747803-17 1995 Thus, administration of NAC may change the normal vasodilator profile of nitrates. Nitrates 73-81 synuclein alpha Homo sapiens 24-27 8534848-6 1995 They were designated as iNR1 and iNR2, respectively, since both were inducible by nitrate. Nitrates 82-89 inducible nitrate reductase [NADH] 2 Glycine max 33-37 8534848-16 1995 In northern blots, the steady-state level of iNR1 mRNA was similar for the nr1 mutant and the wild-type parent after 20 to 48 h induction by nitrate. Nitrates 141-148 inducible nitrate reductase [NADH] 1 Glycine max 45-49 8534848-16 1995 In northern blots, the steady-state level of iNR1 mRNA was similar for the nr1 mutant and the wild-type parent after 20 to 48 h induction by nitrate. Nitrates 141-148 LOC100037451 Glycine max 75-78 7483050-8 1995 Ongoing treatment with diuretics did not seem to be a risk factor for developing reduced kidney function, whereas significantly more patients on treatment with nitrates, indicating generalised atherosclerosis, developed reduced kidney function during treatment with ACE-inhibitors. Nitrates 160-168 angiotensin I converting enzyme Homo sapiens 266-269 7545539-10 1995 Oral administration of N-monomethyl-L-arginine, an inhibitor of nitric oxide synthase (NOS), reduced urinary nitrate excretion and also the severity of myositis. Nitrates 109-116 nitric oxide synthase 1, neuronal Mus musculus 64-85 7561687-10 1995 Similarly, 4% of the embryos from pregnant CD1 mice on days 8 and 12 of gestation produced a significant amount of nitrate, which again correlated with the low incidence of resorption observed in these mice. Nitrates 115-122 CD1 antigen complex Mus musculus 43-46 8556991-4 1995 However, LPS combined with either EGF or PDGF caused a significant increase in nitrite/nitrate concentration relative to LPS alone and growth factor alone. Nitrates 87-94 epidermal growth factor like 1 Rattus norvegicus 34-37 8556991-5 1995 The highest level level of nitrite/nitrate concentration was observed with the triple combination of LPS, EGF, and PDGF. Nitrates 35-42 epidermal growth factor like 1 Rattus norvegicus 106-109 7674685-7 1995 Nitrates are highly effective antianginal drugs with complex beneficial actions in patients with CAD, but their usefulness is limited by development of tolerance during long-term use. Nitrates 0-8 aconitate decarboxylase 1 Homo sapiens 97-100 7565593-2 1995 To check whether Nii host genes and transgenes (encoding nitrite reductase, the second enzyme of the nitrate assimilation pathway) were also susceptible to silencing, a transgene consisting of the tobacco Nii1 gene with two copies of the enhancer of the 35S promoter cloned 1 kb upstream of the Nii promoter region was introduced into tobacco plants. Nitrates 101-108 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 57-74 7643383-0 1995 Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site. Nitrates 0-7 neuronal pentraxin 2 Homo sapiens 171-175 7643383-1 1995 The NarL and NarP proteins are homologous response regulators that function to regulate anaerobic respiratory gene expression in response to nitrate and nitrite in Escherichia coli. Nitrates 141-148 neuronal pentraxin 2 Homo sapiens 13-17 7643383-12 1995 Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro. Nitrates 84-91 neuronal pentraxin 2 Homo sapiens 185-189 7643383-3 1995 aeg-46.5 operon expression is further induced by the NarP protein in response to nitrate or nitrite and this induction is antagonized by NarL. Nitrates 81-88 neuronal pentraxin 2 Homo sapiens 53-57 7643383-12 1995 Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro. Nitrates 84-91 myelin basic protein Homo sapiens 194-197 7643383-13 1995 Presumably, the NarP and NarL proteins compete for the -44.5 binding site to regulate aeg-46.5 operon expression in response to nitrate and nitrite. Nitrates 128-135 neuronal pentraxin 2 Homo sapiens 16-20 7621816-7 1995 Based on its phenotype and expression pattern as well as its structural similarities to NRAMPs and a nitrate transporter in Aspergillus nidulans, we discuss a possible role for MVL in nitrite/nitrate transport and its implications. Nitrates 101-108 Malvolio Drosophila melanogaster 177-180 7539147-5 1995 Paradoxically, constrictions caused by endothelin 1 were decreased in nitrate-tolerant vessels. Nitrates 70-77 endothelin-1 Oryctolagus cuniculus 39-51 7590863-4 1995 In sera of patients, nitrite plus nitrate levels correlated significantly with neopterin, soluble tumor necrosis factor receptor 55 and 75, and beta 2-microglobulin. Nitrates 34-41 beta-2-microglobulin Homo sapiens 144-164 7670778-4 1995 The nitrate serum levels correlated closely with CRP and ESR (r = 0.8, P < 0.001, each). Nitrates 4-11 C-reactive protein Homo sapiens 49-52 7478791-2 1995 The terminal guanidino N-atom of L-arginine is the precursor for NO, which is oxidized to the stable inorganic nitrogen oxides, nitrite (NO2-) and nitrate (NO3-). Nitrates 147-154 NBL1, DAN family BMP antagonist Homo sapiens 156-159 7539147-8 1995 We propose that increased autocrine production of endothelin 1 in nitrate tolerance sensitizes vascular smooth muscle to a variety of vasoconstrictors through a protein kinase C-mediated mechanism. Nitrates 66-73 endothelin-1 Oryctolagus cuniculus 50-62 8630818-1 1995 The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals. Nitrates 133-141 catalase Homo sapiens 301-309 7537701-3 1995 Here we demonstrate that injection of endotoxin into rats leads to the expression of an inducible isoform of .NO synthase (iNOS) in the thoracic aorta at 6 h and an increase in the circulating levels of nitrite/nitrate. Nitrates 211-218 nitric oxide synthase 2 Rattus norvegicus 123-127 7565112-8 1995 Therefore, expression of nuo is regulated by O2 and nitrate via ArcA, NarL, FNR and IHF at sites within the -277 region, and by other factors including C4 dicarboxylates at a site between -277 and -899. Nitrates 52-59 arginine deiminase Escherichia coli 64-68 7536714-2 1995 A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours. Nitrates 125-132 tumor necrosis factor Rattus norvegicus 17-80 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrates 21-28 tumor necrosis factor Rattus norvegicus 62-89 7536714-6 1995 Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment. Nitrates 21-28 interleukin 1 alpha Rattus norvegicus 134-153 12228402-6 1995 In vivo labeling of wheat-leaf PEPC by feeding 32P-labeled orthophosphate showed that PEPC from light plus KNO3 tissue was substantially more phosphorylated than the enzyme in the dark minus-nitrate immunoprecipitates. Nitrates 191-198 phosphoenolpyruvate carboxylase 2 Triticum aestivum 31-35 12228402-6 1995 In vivo labeling of wheat-leaf PEPC by feeding 32P-labeled orthophosphate showed that PEPC from light plus KNO3 tissue was substantially more phosphorylated than the enzyme in the dark minus-nitrate immunoprecipitates. Nitrates 191-198 phosphoenolpyruvate carboxylase 2 Triticum aestivum 86-90 7810695-6 1994 Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions. Nitrates 199-206 renin Rattus norvegicus 14-19 7716247-9 1995 Experiments carried out with detached leaves revealed an influence of light, nitrate, and sucrose on icdh-1 transcript levels and in some cases also on NADP(+)-dependent ICDH activity. Nitrates 77-84 isocitrate dehydrogenase [NADP] Solanum tuberosum 101-107 7716247-10 1995 In darkness, nitrate or sucrose induced icdh-1 mRNA expression. Nitrates 13-20 isocitrate dehydrogenase [NADP] Solanum tuberosum 40-46 7596294-1 1995 The expression of the structural genes nit-3 and nit-6, which encode the nitrate assimilatory enzymes nitrate reductase and nitrite reductase, respectively, is highly regulated by the global-acting NIT2 regulatory protein. Nitrates 73-80 nitrilase family member 2 Homo sapiens 198-202 7539338-10 1995 Using previously published data, we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA, the enhancement of NOS activity in response to TNF, and the elevation of plasma nitrate in response to NO production. Nitrates 239-246 tumor necrosis factor Mus musculus 117-120 8839229-13 1995 The development of ITF 296 as a new orally active nitrate is supported by its pharmacokinetic profile in rats and dogs. Nitrates 50-57 trefoil factor 3 Rattus norvegicus 19-22 7810695-6 1994 Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions. Nitrates 199-206 angiotensinogen Rattus norvegicus 151-157 7810695-7 1994 The amount of renin released in the presence of nitrate was fully additive to RSR values obtained with maximally effective doses of isoproterenol. Nitrates 48-55 renin Rattus norvegicus 14-19 7810695-9 1994 The stimulatory influence of membrane-permeable nitrate anions appears to involve additional pathways and is mediated by a decreased calcium sensitivity of the renin secretory process rather than resulting from an adenosine 3",5"-cyclic monophosphate-dependent action. Nitrates 48-55 renin Rattus norvegicus 160-165 7523451-3 1994 Treatment with IL-1 beta resulted in a marked increase in media nitrite and nitrate accumulation, morphological alterations, and increased release of lactate dehydrogenase (LDH) into media. Nitrates 76-83 interleukin 1 beta Rattus norvegicus 15-24 24306501-7 1994 Feeding nitrate to excised leaves of nitrogen deficient plants enhanced the degree of light activation of PEP carboxylase in the C4 species maize, but had little or no effect in the C3 species wheat. Nitrates 8-15 phosphoenolpyruvate carboxylase 2 Zea mays 106-109 7523382-3 1994 The NO metabolites nitrite and nitrate rose > 10-fold in medium from stimulated versus unstimulated cells over 24 h. Concomitant with elevated nitrogen oxides, Egr-1 mRNA levels declined to 80% below unstimulated cells at 24 h. This decline was blocked by an inhibitor of NO production, NG-monomethyl-L-arginine. Nitrates 31-38 early growth response 1 Rattus norvegicus 163-168 7743368-2 1994 In this pilot study, we wanted to know if the serum values of nitrite/nitrate (NO2/NO3), the stable endproducts of NO biosynthesis, are elevated in patients with septic shock. Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 83-86 7927208-6 1994 Polyclonal rabbit anti-mouse anti-tumor necrosis factor-alpha reduced in vivo tumor necrosis factor-alpha levels (1 hr, 7,332 +/- 1,492 U tumor necrosis factor-alpha per milliliter) and reduced nitric oxide synthesis as measured by plasma nitrite and nitrate (352 +/- 69 mumol/L). Nitrates 251-258 tumor necrosis factor Mus musculus 34-61 7991680-1 1994 Nitrate reductase (NR) is the first enzyme in nitrate assimilation, a critical process for plant survival. Nitrates 46-53 nitrate reductase 1 Arabidopsis thaliana 0-17 7991680-1 1994 Nitrate reductase (NR) is the first enzyme in nitrate assimilation, a critical process for plant survival. Nitrates 46-53 nitrate reductase 1 Arabidopsis thaliana 19-21 7991680-4 1994 We are interested in understanding the mechanism of nitrate induction of higher plant NR genes. Nitrates 52-59 nitrate reductase 1 Arabidopsis thaliana 86-88 7991680-5 1994 Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression. Nitrates 120-127 nitrate reductase 1 Arabidopsis thaliana 81-83 7991680-5 1994 Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression. Nitrates 120-127 nitrate reductase 1 Arabidopsis thaliana 91-94 7991680-5 1994 Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression. Nitrates 120-127 nitrate reductase 2 Arabidopsis thaliana 99-102 7991680-8 1994 Deletion analyses of these regions show that 238- and 188-bp 5" flanking regions of the NR1 and NR2, respectively, contain sequences responsive to nitrate induction. Nitrates 147-154 nitrate reductase 1 Arabidopsis thaliana 88-91 7991680-8 1994 Deletion analyses of these regions show that 238- and 188-bp 5" flanking regions of the NR1 and NR2, respectively, contain sequences responsive to nitrate induction. Nitrates 147-154 nitrate reductase 2 Arabidopsis thaliana 96-99 8182055-1 1994 Nitrate reductase (NR), the first enzyme in the nitrate assimilation pathway, is regulated post-transcriptionally in response to light and CO2. Nitrates 48-55 nitrate reductase 1 Arabidopsis thaliana 0-17 7919993-7 1994 At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport. Nitrates 123-130 nitrate transporter 1.1 Arabidopsis thaliana 162-166 7919993-7 1994 At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport. Nitrates 123-130 solute carrier family 15 member 1 Oryctolagus cuniculus 222-227 7919993-7 1994 At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport. Nitrates 123-130 Ptr2p Saccharomyces cerevisiae S288C 265-270 7867440-3 1994 However, when captopril (CPT, 12.5-25mg, 3 times daily) was combined with nitrates, the clinical effects were enhanced and maintained throughout the study, along with a decrease in the level of AII and body weight. Nitrates 74-82 angiotensinogen Homo sapiens 194-197 8066882-3 1994 The nitrates are inactive prodrugs, and their vascular effects depend on metabolic conversion to vasoactive intermediates like nitric oxide and/or nitrosothiols with subsequent stimulation of guanylate cyclase causing increased formation of cyclic GMP. Nitrates 4-12 5'-nucleotidase, cytosolic II Homo sapiens 248-251 7812715-2 1994 The first step of the pathway, the reduction of nitrate to nitrite, is catalyzed by nitrate reductase, a multi-redox cofactor enzyme which belongs to the class of flavoprotein pyridine nucleotide cytochrome reductases. Nitrates 48-55 nitrate reductase [NADH] 1 Zea mays 84-101 8033999-4 1994 In addition to members of the AAP gene family, an integral membrane protein (NTR1) that shows significant similarities to the low affinity nitrate transporter from Arabidpsis and to peptide transporters from yeast and rabbit was identified. Nitrates 139-146 mRNA splicing protein SPP382 Saccharomyces cerevisiae S288C 77-81 8182055-1 1994 Nitrate reductase (NR), the first enzyme in the nitrate assimilation pathway, is regulated post-transcriptionally in response to light and CO2. Nitrates 48-55 nitrate reductase 1 Arabidopsis thaliana 19-21 8209223-5 1994 Nitrate levels of > 45 mg l-1 were observed in 8% of the well samples in 1989 and 5% of them showed the presence of both elevated levels of nitrate and faecal coliforms. Nitrates 0-7 immunoglobulin kappa variable 1-16 Homo sapiens 29-32 8180640-8 1994 CONCLUSIONS: A controlled clinical trial is needed to clarify how consuming high-nitrate foods correlates with methemoglobin levels in infants younger than 6 months. Nitrates 81-88 hemoglobin subunit gamma 2 Homo sapiens 111-124 7508388-2 1994 Nitric oxide (NO) reductase is an integral membrane component of the anaerobic respiratory chain of Pseudomonas stutzeri that transforms nitrate to dinitrogen (denitrification). Nitrates 137-144 cbb3-type cytochrome c oxidase subunit I Pseudomonas stutzeri 0-27 7914830-1 1994 As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates. Nitrates 235-243 alpha hemoglobin stabilizing protein Homo sapiens 84-119 7914830-1 1994 As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates. Nitrates 235-243 alpha hemoglobin stabilizing protein Homo sapiens 121-125 7914830-1 1994 As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates. Nitrates 235-243 alpha hemoglobin stabilizing protein Homo sapiens 206-210 8180624-1 1994 The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport. Nitrates 80-87 uncharacterized protein Chlamydomonas reinhardtii 48-53 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrates 47-54 Fas (TNF receptor superfamily member 6) Mus musculus 4-7 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrates 47-54 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrates 47-54 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 7507509-3 1994 MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains. Nitrates 47-54 Fas (TNF receptor superfamily member 6) Mus musculus 8-11 8184893-7 1994 Similarly, iodide and nitrate stimulated renin release. Nitrates 22-29 renin Rattus norvegicus 41-46 8132465-7 1994 Results presented here indicate that the increase of sdh and lct expression by nitrate depended on its chemical reduction, which in turn diminished the ArcA-P pool. Nitrates 79-86 arginine deiminase Escherichia coli 152-156 8180624-1 1994 The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport. Nitrates 80-87 uncharacterized protein Chlamydomonas reinhardtii 160-165 8180624-1 1994 The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport. Nitrates 126-133 uncharacterized protein Chlamydomonas reinhardtii 48-53 8180624-1 1994 The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport. Nitrates 126-133 uncharacterized protein Chlamydomonas reinhardtii 160-165 8180624-3 1994 Their nitrate non-utilizing phenotype has been directly complemented by transformation using the pCO-5 plasmid which carries the nar-2, nar-3, and nar-4 clustered genes. Nitrates 6-13 uncharacterized protein Chlamydomonas reinhardtii 147-152 8180624-5 1994 Complementation of the nitrate non-utilizing phenotype of the constructed strains was also achieved by co-transformation with plasmids containing nar-2 and nar-3 genes or nar-2 and nar-4, but not with single plasmids containing each individual gene. Nitrates 23-30 uncharacterized protein Chlamydomonas reinhardtii 181-186 7508220-5 1994 Hepatocyte iNOS messenger RNA (mRNA) levels were correlated with iNOS activity and circulating plasma nitrite and nitrate levels. Nitrates 114-121 nitric oxide synthase 2 Rattus norvegicus 11-15 8087822-3 1994 However, nitrates also exhibit platelet-inhibiting properties, mediated by the same cellular mechanisms operating on smooth muscle cells, i.e., via stimulation of guanylate cyclase and subsequent increase in cytosolic levels of cyclic GMP. Nitrates 9-17 5'-nucleotidase, cytosolic II Homo sapiens 235-238 8185875-6 1994 The principle component of the coating is nitrite ion, which in the presence of ozone is oxidized to nitrate ion on the filter medium (NO2- + O3 produces NO3- + O2). Nitrates 101-108 NBL1, DAN family BMP antagonist Homo sapiens 154-157 8113156-6 1994 Both nitrates and nifedipine induced a significant decrease in DR1/3 (indicating an increase in left ventricular ejection flow) in relation to a reduction of the reflected pressure wave. Nitrates 5-13 down-regulator of transcription 1 Homo sapiens 63-68 8111016-2 1994 In ammonium-grown wild-type cells, nit-1 (nitrate reductase, NR), nar-1, nar-2 and nar-3 (nitrate transporter) genes showed very similar kinetics of expression when transferred to nitrate medium. Nitrates 42-49 uncharacterized protein Chlamydomonas reinhardtii 35-40 8111016-5 1994 In contrast to the other nar transcripts, that nar-4, a gene sharing similar sequences with nar-3, accumulated in small amounts in wild-type cells, and only increased after a long nitrate induction period. Nitrates 180-187 uncharacterized protein Chlamydomonas reinhardtii 47-52 16349084-12 1993 Ectocellular aminopeptidase may be common in marine synechococci and play roles in their nitrogen nutrition, particularly in low-nitrate and low-light environments. Nitrates 129-136 carboxypeptidase Q Homo sapiens 13-27 7509009-2 1993 The combination of interferon-gamma (100 U/ml) and tumor necrosis factor-alpha (5000 U/ml) evoked a time-dependent increase in nitric oxide synthase mRNA and nitrite/nitrate production, both of which were inhibited by dexamethasone. Nitrates 166-173 tumor necrosis factor Rattus norvegicus 19-78 8225220-6 1993 High serum nitrite/nitrate levels were associated with high plasma renin activity, high aldosterone and antidiuretic hormone levels and low urinary excretion of sodium. Nitrates 19-26 renin Homo sapiens 67-72 8248688-4 1993 In parallel with the discovery of the endothelium-derived relaxing factor (EDRF) and its biochemical identification as nitric oxide (NO), it became clear that organic nitrates act via the release of NO in the vascular wall and thus by using metabolic pathways identical to those of endogenous EDRF. Nitrates 167-175 alpha hemoglobin stabilizing protein Homo sapiens 75-79 8286141-3 1993 In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 95-98 8286141-3 1993 In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 316-319 8248688-4 1993 In parallel with the discovery of the endothelium-derived relaxing factor (EDRF) and its biochemical identification as nitric oxide (NO), it became clear that organic nitrates act via the release of NO in the vascular wall and thus by using metabolic pathways identical to those of endogenous EDRF. Nitrates 167-175 alpha hemoglobin stabilizing protein Homo sapiens 293-297 8413188-1 1993 Three overlapping clones covering a Chlamydomonas reinhardtii genomic region of about 32 kb appear to contain five genes potentially involved in nitrate assimilation in addition to the nitrate reductase structural locus nit-1. Nitrates 145-152 uncharacterized protein Chlamydomonas reinhardtii 185-202 8399219-6 1993 However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK. Nitrates 50-57 creatine kinase, mitochondrial 2 Gallus gallus 126-132 8399219-6 1993 However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK. Nitrates 50-57 creatine kinase, mitochondrial 2 Gallus gallus 202-208 8134178-1 1993 In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF). Nitrates 101-108 tumor necrosis factor-like Rattus norvegicus 224-245 8134178-1 1993 In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF). Nitrates 101-108 tumor necrosis factor-like Rattus norvegicus 247-250 8413188-1 1993 Three overlapping clones covering a Chlamydomonas reinhardtii genomic region of about 32 kb appear to contain five genes potentially involved in nitrate assimilation in addition to the nitrate reductase structural locus nit-1. Nitrates 145-152 uncharacterized protein Chlamydomonas reinhardtii 220-225 8413188-2 1993 These new loci produced transcripts of 2.8, 2.2, 1.8 and 1.7 kb in nitrate-induced wild-type cells that, like the 3.4 kb transcript of nit-1, were undetectable in cells grown in ammonium. Nitrates 67-74 nitrilase 1 Mus musculus 135-140 8413188-3 1993 In addition, in a mutant defective at the regulatory locus, nit-2 for nitrate assimilation, which does not express the nit-1 gene transcript, accumulation of the four other transcripts was also blocked. Nitrates 70-77 uncharacterized protein Chlamydomonas reinhardtii 60-65 8391401-2 1993 BACKGROUND: The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Nitrates 265-272 5'-nucleotidase, cytosolic II Homo sapiens 97-100 8391783-8 1993 These results suggest that nitrate-stabilized, dead-end complexes of hexokinase may be useful in stabilizing the closed conformation of this "hinge-bending" enzyme for crystallographic experiments. Nitrates 27-34 hexokinase 1 Homo sapiens 69-79 8368322-4 1993 Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM). Nitrates 8-15 tumor necrosis factor-like Rattus norvegicus 215-218 8368322-4 1993 Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM). Nitrates 119-126 tumor necrosis factor-like Rattus norvegicus 215-218 8391783-2 1993 Nitrate binds to the active site of hexokinase when MnIIADP and a sugar substrate or analogue are present. Nitrates 0-7 hexokinase 1 Homo sapiens 36-46 7682068-3 1993 Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-). Nitrates 159-166 nitric oxide synthase 2 Rattus norvegicus 0-31 8504586-6 1993 In a canine experimental model of acute regional myocardial necrosis, hypertrophy and dilatation appear to have a different time course, and both may be attenuated by pharmacologic intervention with either an angiotensin-converting enzyme (ACE) inhibitor or a nitrate. Nitrates 260-267 angiotensin I converting enzyme Canis lupus familiaris 209-238 8510658-4 1993 Plants in which the NIA2 gene has been deleted retain only 10% of the wild-type shoot NR activity and grow normally with nitrate as the sole nitrogen source. Nitrates 121-128 nitrate reductase 2 Arabidopsis thaliana 20-24 8510658-6 1993 nia1, nia2 double mutants have only 0.5% of wild-type shoot NR activity and display very poor growth on media with nitrate as the only form of nitrogen. Nitrates 115-122 nitrate reductase 1 Arabidopsis thaliana 0-4 8510658-6 1993 nia1, nia2 double mutants have only 0.5% of wild-type shoot NR activity and display very poor growth on media with nitrate as the only form of nitrogen. Nitrates 115-122 nitrate reductase 2 Arabidopsis thaliana 6-10 8510658-8 1993 These results show that the NIA1 gene encodes a functional NR protein that contributes to the assimilation of nitrate in Arabidopsis. Nitrates 110-117 nitrate reductase 1 Arabidopsis thaliana 28-32 8510658-8 1993 These results show that the NIA1 gene encodes a functional NR protein that contributes to the assimilation of nitrate in Arabidopsis. Nitrates 110-117 nitrate reductase 1 Arabidopsis thaliana 59-61 8394263-1 1993 Genetic evidence suggests that the NIT2 gene of Chlamydomonas reinhardtii encodes a positive regulator of the nitrate-assimilation pathway. Nitrates 110-117 uncharacterized protein Chlamydomonas reinhardtii 35-39 8394263-9 1993 These results suggest that repression of the NIT2 gene may mediate metabolite repression of the nitrate assimilation pathway in Chlamydomonas. Nitrates 96-103 uncharacterized protein Chlamydomonas reinhardtii 45-49 8389858-1 1993 Nitrate tolerance has been explained by 1) a direct loss of pharmacological effect due to reduced bioconversion and 2) an indirect effect due to activation of the renin/angiotensin system and counter-regulatory vasoconstriction. Nitrates 0-7 renin Rattus norvegicus 163-168 7682068-3 1993 Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-). Nitrates 159-166 nitric oxide synthase 2 Rattus norvegicus 33-37 8483458-4 1993 Some of these nit-1 or nit-2 mutants were also defective in pathways not directly related to nitrate assimilation, such as those of amino acids and purines. Nitrates 93-100 uncharacterized protein Chlamydomonas reinhardtii 14-19 8453665-2 1993 The CHL1 gene of Arabidopsis, which when mutated confers resistance to the herbicide chlorate and a decrease in nitrate uptake, was isolated and found to encode a protein with 12 putative membrane-spanning segments. Nitrates 112-119 nitrate transporter 1.1 Arabidopsis thaliana 4-8 8453665-3 1993 Injection of CHL1 mRNA into Xenopus oocytes produces a nitrate- and pH-dependent membrane depolarization, inward current, and nitrate uptake. Nitrates 55-62 DEAD/H-box helicase 11 L homeolog Xenopus laevis 13-17 8453665-3 1993 Injection of CHL1 mRNA into Xenopus oocytes produces a nitrate- and pH-dependent membrane depolarization, inward current, and nitrate uptake. Nitrates 126-133 DEAD/H-box helicase 11 L homeolog Xenopus laevis 13-17 8453665-5 1993 CHL1 mRNA is found predominantly in roots and displays nitrate- and pH-dependent regulation. Nitrates 55-62 nitrate transporter 1.1 Arabidopsis thaliana 0-4 8483458-4 1993 Some of these nit-1 or nit-2 mutants were also defective in pathways not directly related to nitrate assimilation, such as those of amino acids and purines. Nitrates 93-100 uncharacterized protein Chlamydomonas reinhardtii 23-28 8437565-5 1993 The accumulation of both leaf and root NiR mRNAs was induced by nitrate and repressed by nitrate- or ammonium-derived metabolites. Nitrates 64-71 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 39-42 8440160-11 1993 The effect of captopril in nitrate tolerance is apparently due to an addition of the anti-ischaemic action of the ACE inhibitor (31%) and the residual effect of the nitrate (26%). Nitrates 27-34 angiotensin I converting enzyme Homo sapiens 114-117 8447474-2 1993 Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media. Nitrates 110-117 interleukin 1 beta Homo sapiens 48-57 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrates 171-178 plasminogen Homo sapiens 0-7 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrates 171-178 interleukin 1 beta Homo sapiens 129-138 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrates 289-296 plasminogen Homo sapiens 0-7 8447474-3 1993 Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta. Nitrates 289-296 interleukin 1 beta Homo sapiens 129-138 8435934-7 1993 ACE inhibitors may reduce tolerance to nitrates, reduce angina in some but not all studies, and limit smooth muscle cell proliferation (and perhaps restenosis) induced by experimental balloon angioplasty. Nitrates 39-47 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus 0-3 8499119-3 1993 In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 95-98 8499119-3 1993 In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors. Nitrates 115-123 angiotensin I converting enzyme Homo sapiens 316-319 8423095-3 1993 Intraperitoneal injection of mice with BCG increased urinary nitrate (NO3-) excretion coincident with development of activated macrophages capable of secreting nitrogen oxides and inhibiting F. tularensis growth in vitro. Nitrates 61-68 NBL1, DAN family BMP antagonist Mus musculus 70-73 8278505-2 1993 A possible physiological role of this enzyme could be in the turnover of nitrate reductase (NR) and, as such, it could be of great importance in regulating the assimilation of nitrate. Nitrates 73-80 nitrate reductase [NADH] 1 Zea mays 92-94 8282225-1 1993 The production of nitrate (NO3-) and nitrite (NO2-) from macrophage-derived NO was studied using EPR and spin trapping. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 8437565-5 1993 The accumulation of both leaf and root NiR mRNAs was induced by nitrate and repressed by nitrate- or ammonium-derived metabolites. Nitrates 89-96 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 39-42 8437574-7 1993 Nitrite reductase activity, measured with dithionite-reduced methyl viologen as electron donor, of the nitrate-treated homozygous nir1 mutant was much reduced but NADH-nitrate reductase activity was elevated compared to wild-type plants. Nitrates 103-110 PITPNM family member 3 Homo sapiens 130-134 16653241-3 1992 Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels. Nitrates 102-109 MLO-like protein 4 Zea mays 132-136 8419922-1 1993 Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 17-20 1336460-1 1992 The structures of human carbonic-anhydrase-II complexes with the anionic inhibitors hydrogen sulphide (HS-) and nitrate (NO3-) have been determined by X-ray diffraction at 0.19-nm resolution from crystals soaked at pH 7.8 and 6.0, respectively. Nitrates 112-119 carbonic anhydrase 2 Homo sapiens 24-45 1336460-1 1992 The structures of human carbonic-anhydrase-II complexes with the anionic inhibitors hydrogen sulphide (HS-) and nitrate (NO3-) have been determined by X-ray diffraction at 0.19-nm resolution from crystals soaked at pH 7.8 and 6.0, respectively. Nitrates 112-119 NBL1, DAN family BMP antagonist Homo sapiens 121-124 16653241-3 1992 Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels. Nitrates 102-109 carbonic anhydrase Zea mays 141-143 16653241-3 1992 Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels. Nitrates 102-109 MLO-like protein 4 Zea mays 204-208 16652938-6 1992 Simultaneous addition of high nitrate and zeatin to leaves detached from N-deficient maize plants caused a large and rapid increase in PEPC and CA mRNA levels. Nitrates 30-37 MLO-like protein 4 Zea mays 135-139 16653041-1 1992 Effects of NO(2) (-), ClO(3) (-), and ClO(2) (-) on the induction of nitrate transport and nitrate reductase activity (NRA) as well as their effects on NO(3) (-) influx into roots of intact barley (Hordeum vulgare cv Klondike) seedlings were investigated. Nitrates 69-76 Clo2 Hordeum vulgare 38-44 1500182-0 1992 In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria. Nitrates 33-40 tumor necrosis factor Mus musculus 44-65 1442583-6 1992 The results of this study demonstrate a preserved vasodilatory effect of organic nitrates in patients already treated with ACE inhibitors. Nitrates 81-89 angiotensin I converting enzyme Homo sapiens 123-126 1442583-7 1992 Nitrates mediated improvement in right and left ventricular filling pressures, and reduction of pulmonary hypertension demonstrates a rationale for the use of these therapeutic methods in combination and suggest the need for long-term evaluation of the effect of nitrate therapy in patients with chronic CHF already treated with ACE inhibitors. Nitrates 0-8 angiotensin I converting enzyme Homo sapiens 329-332 16652938-6 1992 Simultaneous addition of high nitrate and zeatin to leaves detached from N-deficient maize plants caused a large and rapid increase in PEPC and CA mRNA levels. Nitrates 30-37 carbonic anhydrase Zea mays 144-146 16653003-4 1992 The addition of nitrate to wheat seedlings (Triticum aestivum) grown in the absence of exogenous nitrogen has a dramatic, if transient, impact on sucrose formation and on the activities of sucrose phosphate synthase (which is inactivated) and phosphoenolpyruvate carboxylase (which is activated). Nitrates 16-23 phosphoenolpyruvate carboxylase 2 Triticum aestivum 243-274 1621630-5 1992 Infants are particularly susceptible to nitrate poisoning because fetal hemoglobin is more readily oxidized to methemoglobin. Nitrates 40-47 hemoglobin subunit gamma 2 Homo sapiens 111-124 16669032-5 1992 Regulation of the phosphorylation of SPS may provide a general mechanism whereby sucrose formation is coordinated with the rate of photosynthesis and the rate of nitrate assimilation. Nitrates 162-169 sucrose-phosphate synthase Zea mays 37-40 1352550-0 1992 Cytochrome P-450 mediates bioactivation of organic nitrates. Nitrates 51-59 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 1377225-5 1992 Increased levels of nitrite (NO2-) and nitrate (NO3-) in culture supernatants were associated with NADPH-dependent NOS activity in the cell lysates. Nitrates 39-46 NBL1, DAN family BMP antagonist Homo sapiens 48-51 1352550-10 1992 These findings suggest that in intact cells bioactivation of, i.e., nitric oxide formation from organic nitrates is mediated by a cytochrome P-450 enzyme system rather than by glutathione S-transferase or free thiols. Nitrates 104-112 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 130-146 1632143-4 1992 Calcium channel blockers (nifedipine and verapamil) or nitrates (isosorbide dinitrate) decrease LES pressure but do little to the clinical symptomatology of patients with achalasia; however such drug therapy may be tried as an adjunct in patients who remain symptomatic after pneumatic dilatations or myotomy. Nitrates 55-63 fucosyltransferase 3 (Lewis blood group) Homo sapiens 96-99 24178079-0 1992 Coaction of light, nitrate and a plastidic factor in controlling nitrite-reductase gene expression in tobacco. Nitrates 19-26 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 65-82 24178079-1 1992 Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light. Nitrates 54-61 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 0-17 24178079-1 1992 Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light. Nitrates 54-61 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 19-22 24178079-1 1992 Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light. Nitrates 100-107 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 0-17 24178079-1 1992 Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light. Nitrates 100-107 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 19-22 24178079-2 1992 In the present study with tobacco (Nicotiana tabacum L.) seedlings the dependency of NIR gene expression on nitrate, light and a plastidic factor was investigated to establish the nature of the coaction between these controlling factors. Nitrates 108-115 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 85-88 24178079-9 1992 (iv) Northern blot analysis of NIR-transcript levels indicated that a low transcript level existed in the absence of nitrate and light; however, this level appeared to be increased slightly by light (in the absence of nitrate) and by nitrate (in the absence of light). Nitrates 117-124 ferredoxin--nitrite reductase, chloroplastic-like Nicotiana tabacum 31-34 1375656-5 1992 Plasma levels of nitrate (NO3-), the stable end metabolic product of .N = O synthesis, were measured before and at the end of IL-2 treatment cycles. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 1534867-2 1992 Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo). Nitrates 121-128 nitrate reductase 1 Arabidopsis thaliana 166-183 1533499-3 1992 The enzyme was inhibited by the vacuolar ATPase inhibitors nitrate and N-ethylmaleimide; 4-chloro-7-nitrobenzofurazan (NBD-Cl) was also inhibitory. Nitrates 59-66 tRNA(Met) cytidine acetyltransferase TmcA Saccharolobus solfataricus 41-47 1534867-2 1992 Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo). Nitrates 121-128 nitrate reductase 1 Arabidopsis thaliana 185-187 1534867-2 1992 Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo). Nitrates 121-128 nitrate reductase 1 Arabidopsis thaliana 249-251 1530430-6 1992 The interactions of nitrate derivatives with molecules used as platelet inhibitors, such as aspirin, require further study as do interactions with heparin (possible induction of resistance by a qualitative anti-thrombin III deficiency) and thrombolytics (increased clearance of tissue type plasminogen activator). Nitrates 20-27 plasminogen activator, tissue type Homo sapiens 278-311 24178047-6 1992 It appears that in bundle-sheath cells of maize the nitrate-assimilatory capacities of glutamine synthetase (located mainly in the cytosol) and of glutamate synthase (located in the stroma) are high enough to meet the demands of whole maize leaves. Nitrates 52-59 ferredoxin-dependent glutamate synthase, chloroplastic Zea mays 147-165 1314486-3 1992 A combination of lipopolysaccharide (LPS), interferon-gamma, tumor necrosis factor, and interleukin-1 stimulates the biosynthesis of large quantities of nitrite and nitrate (NO2- + NO3-). Nitrates 165-172 interferon gamma Rattus norvegicus 43-59 1541678-4 1992 Activity of this pathway was evaluated by measuring serum and urine nitrate (the stable degradation product of NO) during IL-2 therapy. Nitrates 68-75 interleukin 2 Homo sapiens 122-126 16668807-0 1992 Effects of Nitrate and Ammonium on Gene Expression of Phosphoenolpyruvate Carboxylase and Nitrogen Metabolism in Maize Leaf Tissue during Recovery from Nitrogen Stress. Nitrates 11-18 MLO-like protein 4 Zea mays 54-85 16668807-1 1992 We previously showed that the selective accumulation of phosphoenolpyruvate carboxylase (PEPC) in photosynthetically maturing maize (Zea mays L.) leaf cells induced by nitrate supply to nitrogen-starved plants was primarily a consequence of the level of its mRNA (B Sugiharto, K Miyata, H Nakamoto, H Sasakawa, T Sugiyama [1990] Plant Physiol 92: 963-969). Nitrates 168-175 MLO-like protein 4 Zea mays 56-87 16668807-1 1992 We previously showed that the selective accumulation of phosphoenolpyruvate carboxylase (PEPC) in photosynthetically maturing maize (Zea mays L.) leaf cells induced by nitrate supply to nitrogen-starved plants was primarily a consequence of the level of its mRNA (B Sugiharto, K Miyata, H Nakamoto, H Sasakawa, T Sugiyama [1990] Plant Physiol 92: 963-969). Nitrates 168-175 MLO-like protein 4 Zea mays 89-93 1558158-3 1992 Substitution of Cl- with nitrate (101 mM) stimulated renin secretion. Nitrates 25-32 renin Rattus norvegicus 53-58 1542684-1 1992 Nitrate reductase, the first enzyme in nitrate assimilation, is located at the crossroad of two energy-consuming pathways: nitrate assimilation and carbon fixation. Nitrates 39-46 nitrate reductase 1 Arabidopsis thaliana 0-17 1542684-1 1992 Nitrate reductase, the first enzyme in nitrate assimilation, is located at the crossroad of two energy-consuming pathways: nitrate assimilation and carbon fixation. Nitrates 123-130 nitrate reductase 1 Arabidopsis thaliana 0-17 1541678-5 1992 IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively). Nitrates 86-93 interleukin 2 Homo sapiens 0-4 1541678-5 1992 IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively). Nitrates 221-228 interleukin 2 Homo sapiens 0-4 1541678-6 1992 IL-2-induced renal dysfunction made only a minor contribution to increased serum nitrate levels. Nitrates 81-88 interleukin 2 Homo sapiens 0-4 1541678-8 1992 Our results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans. Nitrates 41-48 interleukin 2 Homo sapiens 81-85 1557942-4 1992 EDRF-NO as well as NO generated from vasodilator nitrates act by activation of soluble guanylate cyclase, elevating cellular cyclic GMP levels, causing vasodilatation and inhibition of platelet aggregation. Nitrates 49-57 5'-nucleotidase, cytosolic II Homo sapiens 132-135 1606187-4 1992 Bradykinin had a stimulating effect on human and bovine endothelial cells and led to a threefold increase of nitrite/nitrate in endothelial cell column perfusates compared to those of unstimulated cells. Nitrates 117-124 kininogen 1 Homo sapiens 0-10 16668656-3 1992 In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite. Nitrates 49-56 uncharacterized protein Chlamydomonas reinhardtii 68-73 1462853-6 1992 As a consequence, SH-containing ACE-inhibitors may potentiate nitrates, because they act as exogenous nitrovasodilators, and reverse tolerance to their therapeutic effect. Nitrates 62-70 angiotensin I converting enzyme Homo sapiens 32-35 1731978-0 1992 Nitrate reductase transcript is expressed in the primary response of maize to environmental nitrate. Nitrates 92-99 nitrate reductase [NADH] 1 Zea mays 0-17 15092051-4 1992 It is suggested that the most likely mechanism for this nitrate production was due to the solution of N2O5 and NO3 formed from the reaction of NO2 with O3. Nitrates 56-63 NBL1, DAN family BMP antagonist Homo sapiens 111-114 1731978-1 1992 The nitrate induction of NADH:nitrate reductase mRNA in maize roots, scutella and leaves was investigated in the presence and absence of inhibitors of protein synthesis. Nitrates 4-11 nitrate reductase [NADH] 1 Zea mays 30-47 1731978-2 1992 In the absence of inhibitors, nitrate treatment caused a fairly rapid (2 to 3 h) increase in the level of the nitrate reductase transcript in all tissues. Nitrates 30-37 nitrate reductase [NADH] 1 Zea mays 110-127 1731978-3 1992 When cytoplasmic protein synthesis was inhibited by cycloheximide, nitrate reductase mRNA was induced by nitrate in all tissues to levels equal to or greater than those found with nitrate treatment alone. Nitrates 105-112 nitrate reductase [NADH] 1 Zea mays 67-84 1790782-4 1991 At least one further site in the nitrate bioconversion cascade, possibly at the level of NO generation appears to be involved in tolerance development, which may also affect the non-nitrate vasodilator SIN-1. Nitrates 33-40 MAPK associated protein 1 Homo sapiens 202-207 1720843-3 1991 In nitrate-tolerant hearts of rats pretreated with isosorbide dinitrate (15 mg daily), the increase in coronary flow by nitroglycerin and bradykinin was significantly less when compared to control hearts. Nitrates 3-10 kininogen 1 Homo sapiens 138-148 16668525-9 1991 Chlorate-treated plants still retain the capacity to make functional NR because NR activity could be restored by irrigating the chlorate-treated plants with nitrate. Nitrates 157-164 nitrate reductase 1 Arabidopsis thaliana 80-82 1911837-3 1991 Addition of the AE1 specific inhibitor 4,4"-dinitrostilbene-2,2"-disulfonate markedly reduced this line-broadening, indicating that the broadening was predominantly due to a specific interaction between nitrate and AE1. Nitrates 203-210 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 16-19 1911837-0 1991 The binding of nitrate to the human anion exchange protein (AE1) studied with 14N nuclear magnetic resonance. Nitrates 15-22 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 60-63 1911837-4 1991 The dependence of the AE1 specific line-broadening on nitrate concentration had a first-order dissociation constant KD of 6.9 +/- 0.9 mM. Nitrates 54-61 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 22-25 1911837-5 1991 In contrast, Cl- interaction with AE1 studied by 35Cl-NMR showed a chloride concentration-dependent line-broadening with a KD of 74 +/- 10 mM, indicating that AE1 has a higher affinity for nitrate than for chloride. Nitrates 189-196 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 34-37 1911837-5 1991 In contrast, Cl- interaction with AE1 studied by 35Cl-NMR showed a chloride concentration-dependent line-broadening with a KD of 74 +/- 10 mM, indicating that AE1 has a higher affinity for nitrate than for chloride. Nitrates 189-196 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 159-162 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Nitrates 0-7 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 86-89 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Nitrates 0-7 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 123-126 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Nitrates 73-80 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 86-89 1911837-8 1991 Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction. Nitrates 73-80 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 123-126 1911837-9 1991 The 14N-NMR nitrate binding assay, along with the 35Cl-NMR binding assay now in use, will provide a powerful tool for studying the structure of the AE1 binding site for both physiologic substrates, bicarbonate and chloride. Nitrates 12-19 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 148-151 1901528-12 1991 Body weight increased only in the placebo group, suggesting prevention of nitrate-induced volume expansion in the ACE inhibitor groups. Nitrates 74-81 angiotensin I converting enzyme Homo sapiens 114-117 1712676-11 1991 The activity for forming L-citrulline and nitrite/nitrate from L-arginine was markedly induced by treatment with either LPS alone or LPS + IFN-gamma but not with IFN-gamma. Nitrates 50-57 interferon gamma Mus musculus 139-148 1831867-1 1991 Effects of nicorandil (2-nicotinamidoethyl nitrate), a nitrate derivative with a K+ channel-opening action, on endothelin-1 (ET)-induced effects on peripheral blood vessels were studied using a hind-limb perfusion preparation in rats. Nitrates 43-50 endothelin 1 Rattus norvegicus 111-123 1903680-0 1991 Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta. Nitrates 12-20 coagulation factor II, thrombin Homo sapiens 33-41 1903680-6 1991 However, the nitrates fully inhibited the release of the peptide induced by thrombin (4 units/ml). Nitrates 13-21 coagulation factor II, thrombin Homo sapiens 76-84 1874272-3 1991 EDRF-NO and NO generated from vasodilator nitrates work by activation of soluble guanylate cyclase, elevating cyclic guanosine monophosphate (GMP) levels to cause vasodilatation and inhibition of platelet aggregation. Nitrates 42-50 alpha hemoglobin stabilizing protein Homo sapiens 0-4 16668164-3 1991 Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2. Nitrates 9-16 nitrate reductase 1 Arabidopsis thaliana 71-74 16668164-3 1991 Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2. Nitrates 9-16 nitrate reductase 2 Arabidopsis thaliana 143-146 16668164-3 1991 Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2. Nitrates 106-113 nitrate reductase 1 Arabidopsis thaliana 71-74 1906734-6 1991 Dipyridamole, a phosphodiesterase (PDe) inhibitor, significantly potentiated the responses to SIN1 on control rings (EC50 = 57.1 +/- 1.8 nM), and on NTG-tolerant rings it reversed the responsiveness to SIN1 (EC50 = 88.9 +/- 9.2 nM), which suggests that nitrate tolerance may be partially due to an increase in PDe activity. Nitrates 253-260 MAPK associated protein 1 Homo sapiens 94-98 1901528-13 1991 CONCLUSIONS: This study demonstrates that ACE inhibitors may prevent nitrate tolerance to long-term nitrate therapy. Nitrates 69-76 angiotensin I converting enzyme Homo sapiens 42-45 1901528-13 1991 CONCLUSIONS: This study demonstrates that ACE inhibitors may prevent nitrate tolerance to long-term nitrate therapy. Nitrates 100-107 angiotensin I converting enzyme Homo sapiens 42-45 1906734-0 1991 Effect of nitrate tolerance and dipyridamole on the response to SIN1 in the human isolated saphenous vein. Nitrates 10-17 MAPK associated protein 1 Homo sapiens 64-68 16667965-1 1991 The level of nitrate reductase (NR) and nitrite reductase (NiR) varied in both shoot and root tissue from nitrate-fed Zea mays L. grown under a 16-hour light/8-hour dark regime over a 10-day period postgermination, with peak activity occurring in days 5 to 6. Nitrates 13-20 nitrate reductase [NADH] 1 Zea mays 32-34 1846742-2 1991 Reduction of nitrate, or nitrite, to N2O under aerobic conditions involves NO as an intermediate, as judged by trapping experiments with the ferric form of extracellular horse heart cytochrome c and the demonstration that the cells possess a nitric oxide reductase activity. Nitrates 13-20 cytochrome c, somatic Equus caballus 182-194 1988109-2 1991 We show here that FAA and structurally related analogues increase plasma nitrite plus nitrate (NO2-/NO3-) levels in mice. Nitrates 86-93 NBL1, DAN family BMP antagonist Mus musculus 95-103 1864311-0 1991 Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats. Nitrates 0-7 growth hormone releasing hormone Rattus norvegicus 77-108 1864311-7 1991 Nitrate exposure is characterized by hypothyroidism, food intake depression, low Sm-C/IGF-I concentrations in plasma and a decreased hypothalamic GRF content. Nitrates 0-7 insulin-like growth factor 1 Rattus norvegicus 86-91 1989691-4 1991 Nitrate reductase specific mRNA can be observed within 2 h after nitrate treatment. Nitrates 65-72 inducible nitrate reductase [NADH] 1 Glycine max 0-17 1989691-5 1991 Levels peaked 48 h after nitrate treatment, while the addition of glutamine to nitrate diminished amounts of nitrate reductase specific mRNA. Nitrates 79-86 inducible nitrate reductase [NADH] 1 Glycine max 109-126 1859433-0 1991 Regulation of phosphoenolpyruvate carboxylase from maize leaves by nitrate and alanine. Nitrates 67-74 MLO-like protein 4 Zea mays 14-45 1859433-1 1991 Nitrate and alanine were found to stimulate partially purified maize leaf phosphoenolpyruvate carboxylase under specific assay conditions. Nitrates 0-7 MLO-like protein 4 Zea mays 74-105 1649801-5 1991 In a cohort of 1,148 male fertilizer workers who had never been exposed to nitrate, there was an increased incidence of lung cancer (SMR = 151,95% CI = 103-220) but not of stomach cancer or prostate cancer. Nitrates 75-82 LY6/PLAUR domain containing 4 Homo sapiens 133-136 1776339-1 1991 SIN 1, the bioactive metabolite of molsidomine, not only appears to lack the problem of inducing nitrate tolerance, but also exerts antiaggregatory and fibrinolytic properties. Nitrates 97-104 MAPK associated protein 1 Homo sapiens 0-5 1965331-7 1990 These results suggest that in intact cells, glyceryl trinitrate-induced cyclic GMP stimulation is dependent on cytochrome P-450 enzymes which may be relevant for nitric oxide formation from organic nitrates. Nitrates 198-206 cytochrome P450 family 2 subfamily D member 6 Sus scrofa 111-127 2124251-1 1990 The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma). Nitrates 89-96 NBL1, DAN family BMP antagonist Mus musculus 98-101 2124251-1 1990 The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma). Nitrates 89-96 interferon gamma Mus musculus 124-151 24197373-2 1990 This is demonstrated by the properties of the associated ATPase: high vanadate sensitivity, azide and nitrate insensitivity, sharp pH optimum around 6.5, and high specificity for ATP as substrate. Nitrates 102-109 dynein axonemal heavy chain 8 Homo sapiens 57-63 2128204-7 1990 This suggests that the biotransformation of organic nitrates can occur through the direct interaction with the heme moiety of cytochrome P-450. Nitrates 52-60 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 126-142 2128204-10 1990 These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation. Nitrates 89-97 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 24-40 2128204-10 1990 These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation. Nitrates 89-97 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 139-155 2128204-10 1990 These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation. Nitrates 224-232 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 24-40 2128204-10 1990 These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation. Nitrates 224-232 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 139-155 2382514-3 1990 Nitrate (in the assayed range 0 to 800 mg/L) and high concentrations of ascorbic acid (4 to 8 g/L) slightly inhibited cathepsin D. Nitrates 0-7 cathepsin D Homo sapiens 118-129 16667714-3 1990 CA activity was reduced in plants grown under nitrogen deficiency and recovered only slowly when supplemented with nitrate. Nitrates 115-122 carbonic anhydrase Zea mays 0-2 24197091-5 1990 Seedlings germinated from seeds (pericarp was removed) without external N-supply are able to take up nitrate immediately upon exposure via a low-capacity uptake system (vmax = 0.8 mumol NO 3 (-) (g root FW)(-1) h(-1); Ks = 0.12 mM). Nitrates 101-108 NBL1, DAN family BMP antagonist Homo sapiens 186-190 24197091-7 1990 Induction of a high-capacity nitrate-uptake system (vmax = 3.4 mumol NO 3 (-) (g root FW)(-1) h(-1); Ks = 0.08 mM) by externally supplied nitrate occurs after a 20-min lag and requires protein synthesis. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 69-73 24197091-7 1990 Induction of a high-capacity nitrate-uptake system (vmax = 3.4 mumol NO 3 (-) (g root FW)(-1) h(-1); Ks = 0.08 mM) by externally supplied nitrate occurs after a 20-min lag and requires protein synthesis. Nitrates 139-146 NBL1, DAN family BMP antagonist Homo sapiens 69-73 2354740-6 1990 Average nitrate intake was 52 mg NO3-/day, about 25% of the ADI. Nitrates 8-15 NBL1, DAN family BMP antagonist Homo sapiens 33-36 1972336-10 1990 At this temperature, even weak chaotropic anions (fluoride, chloride and nitrate), while in combination with non-ionic detergents that solubilized mosquito AChE efficiently, reduced the enzyme activity of these fractions. Nitrates 73-80 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 75-82 NOD3 Glycine max 20-26 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 75-82 NOD3 Glycine max 28-34 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 75-82 NOD3 Glycine max 40-46 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 88-95 NOD3 Glycine max 20-26 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 88-95 NOD3 Glycine max 28-34 16667382-2 1990 nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting. Nitrates 88-95 NOD3 Glycine max 40-46 16667382-6 1990 NOD1-3 was most tolerant of nitrate among the mutants tested and showed the highest relative abundance of ureides. Nitrates 28-35 NOD3 Glycine max 0-6 16667382-10 1990 Unexpectedly, nitrate treatment also increased the rate of ureide degradative capacity of leaves in both NOD1-3 and Williams. Nitrates 14-21 NOD3 Glycine max 105-111 2102014-4 1990 Since the eight day of perfusion all the effluents had an important concentration of nitrate (Figure 1), exceeding in them, the sum of [No-2-N] an [NO-3-N] (Table 1) the concentration of th NO-2-N of the perfusion solution. Nitrates 85-92 NBL1, DAN family BMP antagonist Homo sapiens 148-152 2115855-9 1990 The cause of nitrate tolerance is regarded as an insufficient or absent stimulation of guanylate cyclase and, consequently, inadequate generation of cyclic GMP due to availability of thiol substrate. Nitrates 13-20 5'-nucleotidase, cytosolic II Homo sapiens 156-159 2111676-3 1990 The mechanism of tolerance to nitrates is multifactorial, related on the one hand to depletion of sulfhydryl groups in the body and on the other to activation of the sympathetic and renin-angiotensin systems. Nitrates 30-38 renin Homo sapiens 182-187 33971470-1 2021 Fluoride (F-) and nitrate (NO3-) in groundwater have caused serious health problems worldwide. Nitrates 18-25 NBL1, DAN family BMP antagonist Homo sapiens 27-30 2113002-10 1990 Thus, the administration of low doses of nitrates that act by means of the NO radical can increase the diameter in the stenosis, since the physiological dilator (EDRF) is no longer present. Nitrates 41-49 alpha hemoglobin stabilizing protein Homo sapiens 162-166 33968104-1 2021 As important electron carriers, ferredoxin (Fd) proteins play important roles in photosynthesis, and the assimilation of CO2, nitrate, sulfate, and other metabolites. Nitrates 126-133 ferredoxin Zea mays 32-42 33822357-21 2021 Based on low-certainty evidence, beta-blockers plus nitrates had a higher number of "any adverse events (number of participants)" than beta-blockers alone (OR 3.41, 95% CrI 1.11 to 11.28; 1 trial, 57 participants). Nitrates 52-60 EP300 interacting inhibitor of differentiation 1 Homo sapiens 169-174 33822357-24 2021 Based on low-certainty evidence, any variceal bleed was higher in nitrates than beta-blockers (direct comparison HR 6.40, 95% CrI 1.58 to 47.42; 1 trial, 52 participants). Nitrates 66-74 EP300 interacting inhibitor of differentiation 1 Homo sapiens 126-131 33804377-4 2021 The nitrate concentrations in the drinking water ranged from 3.55 mg/L to 26.75 mg/L as NO3-. Nitrates 4-11 NBL1, DAN family BMP antagonist Homo sapiens 88-91 29378007-9 2018 Nitrate-independent phenotypes were found with higher seed abortion in atg5 and early browing, higher total protein concentrations in the viable seeds of this mutant as compared to the WT. Nitrates 0-7 SAC domain-containing protein 8 Arabidopsis thaliana 71-75 33031018-1 2020 Ingestion of dietary nitrate (NO3-) is associated with improved exercise tolerance and reduced oxygen (O2) cost of exercise, ascribed to enhanced mitochondrial efficiency, muscle contractile function or other factors. Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 30-33 32794734-5 2020 Adding nitrate to a solution of the [Cm(nPr-BTP)3]3+ complex in 2-propanol shifts the Cm(III) emission band from 613.1 to 617.3 nm. Nitrates 7-14 neuronal pentraxin receptor Homo sapiens 40-43 32794734-12 2020 The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex. Nitrates 71-78 neuronal pentraxin receptor Homo sapiens 34-37 32794734-12 2020 The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex. Nitrates 71-78 NBL1, DAN family BMP antagonist Homo sapiens 44-47 32794734-12 2020 The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex. Nitrates 71-78 neuronal pentraxin receptor Homo sapiens 119-122 32794734-13 2020 Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate. Nitrates 112-119 neuronal pentraxin receptor Homo sapiens 20-23 32794734-13 2020 Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate. Nitrates 112-119 NBL1, DAN family BMP antagonist Homo sapiens 30-33 32794734-13 2020 Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate. Nitrates 112-119 NBL1, DAN family BMP antagonist Homo sapiens 36-39 32794734-14 2020 Finally, DFT calculations reveal that the energetically most favored structure is obtained if the nitrate is positioned on the C2 axis of the D3 symmetrical [Cm(nPr-BTP)3]3+ complex with a bond distance of 413 pm. Nitrates 98-105 neuronal pentraxin receptor Homo sapiens 161-164 25805369-7 2015 The spatial distribution of NO3--N export from hydrologic response units (HRUs) identified the agricultural areas with surplus N that are vulnerable to nitrate contamination. Nitrates 152-159 NBL1, DAN family BMP antagonist Homo sapiens 28-31 31139154-9 2019 The maximum rates of different redox metabolisms (mM electron acceptors reduced g-1 soil d-1) in soil containing biogenic nitrate followed as: NO3 1- reduction 4.01 +- 0.22, Fe3+ reduction 5.37 +- 0.12, SO4 2- reduction 9.56 +- 0.16, and CH4 production (mug g-1 soil) 0.46 +- 0.05. Nitrates 122-129 NBL1, DAN family BMP antagonist Homo sapiens 143-146 31139154-11 2019 Raman spectra indicated that aliphatic hydrocarbons increased in soil during nitrification, and these compounds probably bind to NO3 to form biogenic nitrate. Nitrates 150-157 NBL1, DAN family BMP antagonist Homo sapiens 129-132 25762424-5 2015 The best retrieval of modeled nitrate (R2=0.527, root mean square error (RMSE)=3.72, and mean normalized bias (MNB)=0.821) was observed for the postmonsoon season due to the better retrieval of both SST MODIS (28 February 2012, R2=0.651, RMSE=2.037, and MNB=0.068) and chl OCM-2 (R2=0.534, RMSE=0.317, and MNB=0.27). Nitrates 30-37 oncomodulin 2 Homo sapiens 273-278 25762424-6 2015 Present results confirm that the chl OCM-2 and SST MODIS retrieve nitrate well than the MODIS-derived chl and SST largely due to the better retrieval of chl by OCM-2 than MODIS. Nitrates 66-73 oncomodulin 2 Homo sapiens 37-42 23214130-4 2012 Two families of proton-coupled symporters, NRT1 and NRT2, and one type of proton-coupled antiporters, CIC, have been shown to be involved in nitrate transport in higher plants. Nitrates 141-148 nitrate transporter 1.1 Arabidopsis thaliana 43-47 23214130-5 2012 The recent progress in research on NRT1 proteins has shed the light on the localization and physiological function of those nitrate transporters in the NO3(-) uptake, NO3(-) cell-to-cell and tissue-to-tissue distribution, nitrates accumulation and efflux within the model plant Arabidopsis thaliana. Nitrates 222-230 nitrate transporter 1.1 Arabidopsis thaliana 35-39 34953459-3 2022 The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds. Nitrates 146-150 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-54 7579165-3 1995 In this paper, we present detailed evidence to show that PMA mimics the red light effect and follows similar kinetics to enhance NR steady-state transcript accumulation in a nitrate-dependent manner. Nitrates 174-181 nitrate reductase [NADH] 1 Zea mays 129-131 34953459-3 2022 The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds. Nitrates 304-311 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-54 34743794-1 2022 The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water. Nitrates 35-42 NBL1, DAN family BMP antagonist Homo sapiens 44-47 34863569-5 2022 The AO7 removal performance of PC-MnOx was slightly decreased in natural waterbodies and in the presence of CO32-, while it showed an anti-interference capacity for Cl-, NO3- and humic acid. Nitrates 170-174 ring finger protein 25 Homo sapiens 4-7 34743794-1 2022 The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water. Nitrates 185-192 NBL1, DAN family BMP antagonist Homo sapiens 44-47 34743794-1 2022 The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water. Nitrates 185-192 NBL1, DAN family BMP antagonist Homo sapiens 194-197 34743794-4 2022 The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode. Nitrates 367-374 NBL1, DAN family BMP antagonist Homo sapiens 28-31 34743794-4 2022 The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode. Nitrates 367-374 NBL1, DAN family BMP antagonist Homo sapiens 120-123 34743794-4 2022 The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode. Nitrates 367-374 NBL1, DAN family BMP antagonist Homo sapiens 316-319 34806833-0 2022 Electrified conversion of contaminated water to value: selective conversion of aqueous nitrate to ammonia in a PEM cell. Nitrates 87-94 mucin 1, cell surface associated Homo sapiens 111-114 34896495-4 2022 Nowadays, there is increasing concern about the presence of nitrates (NO3-) in groundwaters as a consequence of the intensive use of fertilizers and other anthropogenic sources, such as sewage or industrial wastewater discharge. Nitrates 60-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 34896495-6 2022 Thus, this work collects data from the literature regarding the presence of nitrates in groundwater, and, simultaneously, it reviews the main alternatives available to remove NO3- from groundwater sources. Nitrates 76-84 NBL1, DAN family BMP antagonist Homo sapiens 175-178 34806833-1 2022 The application of a polymer electrolyte membrane (PEM) electrolytic cell for continuous conversion of nitrate, one of the contaminants in water, to ammonia at the cathode was explored in the present work. Nitrates 103-110 mucin 1, cell surface associated Homo sapiens 51-54 34500153-4 2022 Then, the dissociation of CMC-DD2 was efficiently triggered by intracellular hydrogen peroxide (H2O2) with the release of DNA damaging agents, including nitrate anions, hydroxyl radicals ( OH) and DD2. Nitrates 153-160 aldo-keto reductase family 1 member C2 Homo sapiens 30-33 34343879-1 2022 Electroreduction of nitrate (NO3-) to value-added ammonia (NH3) provides an alternative to NH3 production industry and remediation of NO3--containing wastewater. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 29-32 34509834-5 2022 The nitrate mass fraction increased during the three haze episodes, with nitrate accounting for 27-33% of PM1 mass. Nitrates 73-80 transmembrane protein 11 Homo sapiens 106-109 34343879-1 2022 Electroreduction of nitrate (NO3-) to value-added ammonia (NH3) provides an alternative to NH3 production industry and remediation of NO3--containing wastewater. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 134-137 34914357-1 2022 Electrocatalytic nitrate (NO3-) reduction to N2 via atomic hydrogen (H*) is a promising approach for advanced water treatment. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 34923327-1 2022 The present research reports the level of nitrate (NO3-), associated health risks and possible sources of contamination in groundwater from south India. Nitrates 42-49 NBL1, DAN family BMP antagonist Homo sapiens 51-54 34426281-2 2022 The scope of this work is the development of a mechanistic biokinetic model, based on first principles and a robust thermodynamic basis, to provide a theoretical accurate description of a MET system that would treat water contaminated with nitrate, the most common aquifer water pollutant, in absence of external electron donors. Nitrates 240-247 SAFB like transcription modulator Homo sapiens 188-191 34940921-10 2022 There was an increase in nitrate levels of CSF and CSF/plasma ratio of nitrate in patients with PD and LID compared to the healthy controls. Nitrates 25-32 colony stimulating factor 2 Homo sapiens 43-46 34940921-10 2022 There was an increase in nitrate levels of CSF and CSF/plasma ratio of nitrate in patients with PD and LID compared to the healthy controls. Nitrates 71-78 colony stimulating factor 2 Homo sapiens 51-54 34814021-8 2022 In case of NaOH as the electrolyte, the single-pass nitrate removal efficiency, selectivity to nitrogen formation and nitrate removal rate was 90.66%, 96.40% and 1.47 x 10-3 mmol min-1 cm-2, respectively. Nitrates 52-59 CD59 molecule (CD59 blood group) Homo sapiens 179-189 34814021-8 2022 In case of NaOH as the electrolyte, the single-pass nitrate removal efficiency, selectivity to nitrogen formation and nitrate removal rate was 90.66%, 96.40% and 1.47 x 10-3 mmol min-1 cm-2, respectively. Nitrates 118-125 CD59 molecule (CD59 blood group) Homo sapiens 179-189 34974023-3 2022 Ice cores contain records of nitrogen species of nitrate (NO3-) and ammonium (NH4+), hence provide valuable long-term data to study past variations of atmospheric nitrogen deposition. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 58-61 34967938-7 2021 RESULTS: Administration of Klotho protein resulted in mitigation of injury, decreased level of NOX2 and NOX4, reduced generation of ROS/RNS and hydrogen peroxide (H2O2), decreased expression of inducible NOS and limited production of nitrates/nitrites in cells under I/R. Nitrates 234-242 klotho Homo sapiens 27-33 34968494-11 2022 Inorganic nitrites and nitrates can decrease the risk for osteoporotic fracture probably directly by decreasing osteoclast activity, decreasing fat accumulation in the marrow cavity, increasing osteoblast activity, and increasing bone perfusion or indirectly, by improving hyperglycemia, insulin resistance, and reducing body weight. Nitrates 23-31 insulin Homo sapiens 288-295 34919376-6 2021 Owing to the strong adsorption of nitrate on Fe0 active sites generated via topotactic conversion and in situ electroreduction, 2D Fe-cyano electrocatalyst exhibits high catalytic activity with a yield rate of 42.1 mg h-1 mgcat-1 and a Faradaic efficiency of over 90% toward NH3 production at -0.5 V (vs reversible hydrogen electrode, RHE). Nitrates 34-41 factor interacting with PAPOLA and CPSF1 Homo sapiens 335-338 34467905-7 2021 In comparison with a control, the Kyoto Encyclopedia of Genes and Genomes analysis showed that wastewater salinity weakened the functional gene level of MBR microbial flora, and the enzyme key to the assimilation nitrate reduction changed from nitrate reductase to assimilation nitrate reductase. Nitrates 213-220 translocator protein Homo sapiens 153-156 34467905-7 2021 In comparison with a control, the Kyoto Encyclopedia of Genes and Genomes analysis showed that wastewater salinity weakened the functional gene level of MBR microbial flora, and the enzyme key to the assimilation nitrate reduction changed from nitrate reductase to assimilation nitrate reductase. Nitrates 278-285 translocator protein Homo sapiens 153-156 34927377-1 2022 Nitrate (NO 3 - ) as a common pollutant under groundwater causes drinking water safety problems and seriously endangers people"s health. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-13 34927377-2 2022 Electrochemistry reduction nitrate to ammonia under ambient condition is a green and significant route to reduce the concentration of NO 3 - and produce ammonia (NH 3 ), known as a complement to the Haber-Bosch reaction. Nitrates 27-34 NBL1, DAN family BMP antagonist Homo sapiens 134-138 34870671-1 2021 Nitrogen speciation, i.e. distinguishing nitrate (NO3-) and ammonium (NH4+), is commonly undertaken in soil studies, but has not been conducted extensively for lichens. Nitrates 41-48 NBL1, DAN family BMP antagonist Homo sapiens 50-53 34536740-1 2021 Nitrate (NO3-) leaching has negative human and environmental health consequences that can be attributed to and mitigated by agricultural decision making. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34618055-1 2021 Nitrate (NO3) assimilation and signaling regulate plant growth through the relevant function of the transcription factor NIN-like Protein7 (NLP7). Nitrates 0-7 NIN like protein 7 Arabidopsis thaliana 121-138 34912897-9 2021 Methanolic extract of S. kurramense decreased CCl4-induced hepatotoxicity by increasing the antioxidant status and reducing H2O2 and nitrate content generation as well as reducing DNA damage. Nitrates 133-140 C-C motif chemokine ligand 4 Rattus norvegicus 46-50 34524462-0 2021 STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity. Nitrates 32-39 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 0-5 34524462-0 2021 STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity. Nitrates 32-39 nitrate transporter 1.1 Arabidopsis thaliana 16-22 34524462-3 2021 Here, we showed that in the roots of Arabidopsis thaliana, the C2H2-type transcription factor STOP1 in the nucleus was enriched by low pH in a nitrate-independent manner, with the spatial expression pattern of NITRATE TRANSPORTER 1.1 (NRT1.1) established by low pH required the action of STOP1. Nitrates 143-150 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 94-99 34524462-5 2021 Molecular assays revealed that STOP1 directly bound to the promoter of NRT1.1 to activate its transcription in response to low pH, thus upregulating its nitrate uptake. Nitrates 153-160 C2H2 and C2HC zinc fingers superfamily protein Arabidopsis thaliana 31-36 34524462-5 2021 Molecular assays revealed that STOP1 directly bound to the promoter of NRT1.1 to activate its transcription in response to low pH, thus upregulating its nitrate uptake. Nitrates 153-160 nitrate transporter 1.1 Arabidopsis thaliana 71-77 34618055-1 2021 Nitrate (NO3) assimilation and signaling regulate plant growth through the relevant function of the transcription factor NIN-like Protein7 (NLP7). Nitrates 0-7 NIN like protein 7 Arabidopsis thaliana 140-144 34225116-7 2021 STL addition enhanced nitrification at high temperatures during composting, thus increasing the nitrate content of compost by 2-10 times compared with that of the control group (using tap water as a moisture conditioning agent). Nitrates 96-103 RNF217 antisense RNA 1 (head to head) Homo sapiens 0-3 34926901-1 2021 Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34926901-1 2021 Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 102-105 34273081-1 2021 Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34273081-1 2021 Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 151-154 34467886-1 2021 The annual mean PM2.5 mass concentration has decreased because of the stringent emission controls implemented in Beijing, China in recent years, whereas the nitrate NO3- mass fraction in PM2.5 increases gradually. Nitrates 157-164 NBL1, DAN family BMP antagonist Homo sapiens 165-168 33342321-6 2021 mC2 sponges exhibited superior in-vitro drug release profiles where ~100% of tenoxicam released within 5 min for fast pain relief with a more prolonged miconazole nitrate release. Nitrates 163-170 complement component 2 (within H-2S) Mus musculus 0-3 34328901-0 2021 Mix-cultured aerobic denitrifying bacterial communities reduce nitrate: Novel insights in micro-polluted water treatment at lower temperature. Nitrates 63-70 Mix paired-like homeobox Homo sapiens 0-3 34486076-7 2021 We selected seven homologs containing conserved features of AtRIN4, including two NOI (Nitrate induced) domains, each containing a predicted cleavage site for AvrRpt2, and a C-terminal palmitoylation site predicted to mediate membrane tethering of the proteins. Nitrates 87-94 RPM1 interacting protein 4 Arabidopsis thaliana 60-66 34758438-4 2021 The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 38-41 34758438-4 2021 The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 104-107 34758438-4 2021 The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 132-135 34842136-6 2021 Compared to wild-type mice, isolated perfused kidneys of C451A-ERalpha mice revealed a decreased flow-mediated nitrate production and an increased H2O2 production. Nitrates 111-118 estrogen receptor 1 (alpha) Mus musculus 63-70 34856430-6 2021 A new conversion mechanism was proposed that CN- was activated into electron-deficient cyanide radical ( CN) by OH, and then the CN intermediates reacted with O2- via nucleophilic addition to quickly form NO3-, preventing the formation of CNO- and promoting the mineralization of cyanide. Nitrates 208-212 biogenesis of lysosomal organelles complex 1 subunit 4 Homo sapiens 242-245 34352479-3 2021 Moreover, the hydrochemical parameters and the delta15N and delta18O values of nitrate were employed to quantitatively trace the sources and biochemical transformation of NO3-, and the contribution ratios of different NO3- sources were estimated using the stable isotope analysis in R based on the Bayesian model. Nitrates 79-86 NBL1, DAN family BMP antagonist Homo sapiens 171-174 34800458-7 2022 In wintertime, maximum nitrate concentrations (up to 73 mg NO3/L) and loads (up to 1300 t NO3/a; up to 98% in winter) correlate with high-flow conditions. Nitrates 23-30 NBL1, DAN family BMP antagonist Homo sapiens 59-64 34767107-6 2021 Nitrate concentrations in the rural and urban areas were within 0.4-137 mg/L NO3- and 2.9-209 mg/L NO3-, respectively. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 77-80 34252777-4 2021 DON<1kDa dominated the DON pool and significantly correlated inversely with DIN, indicating the DON<1kDa mineralized into nitrate. Nitrates 122-129 neuregulin 2 Homo sapiens 96-101 34328950-1 2021 Nitrate (NO3) radical is an important oxidant in the atmosphere as it regulates the NOx budget and impacts secondary pollutant formation. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34328950-5 2021 Specifically, for the N2O5 uptake, the rapid increase in NO3 production, or to some extent, NO3 oxidation capacity, far outweighed the negative shift effect, leading to a net enhancement of N2O5 uptake in winter, which indicates that the action policy implemented led to an adverse effect on particulate nitrate formation via N2O5 uptake in winter. Nitrates 304-311 NBL1, DAN family BMP antagonist Homo sapiens 57-60 34328950-5 2021 Specifically, for the N2O5 uptake, the rapid increase in NO3 production, or to some extent, NO3 oxidation capacity, far outweighed the negative shift effect, leading to a net enhancement of N2O5 uptake in winter, which indicates that the action policy implemented led to an adverse effect on particulate nitrate formation via N2O5 uptake in winter. Nitrates 304-311 NBL1, DAN family BMP antagonist Homo sapiens 92-95 34767107-6 2021 Nitrate concentrations in the rural and urban areas were within 0.4-137 mg/L NO3- and 2.9-209 mg/L NO3-, respectively. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 99-102 34677563-1 2021 High-quality CoP nanorings (CoP NRs) are easily achieved using a phosphorating treatment of CoOOH nanorings, and reveal high activity towards the hydrogen evolution reaction and the nitrate electrocatalytic reduction reaction due to substantial coordinately unsaturated active sites, a high surface area, and available mass transfer pathways. Nitrates 182-189 caspase recruitment domain family member 16 Homo sapiens 13-16 34764268-8 2021 These inhibitory impacts of nitrate on symbiosis occur in a Nlp1 and Nlp4 dependent manner and contrast with the positive influence of nitrate on cytokinin biosynthesis that occurs in species that do not form symbiotic root nodules. Nitrates 28-35 NLP1 Lotus japonicus 60-64 34618046-0 2021 CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth. Nitrates 49-56 calmodulin-like 38 Arabidopsis thaliana 0-18 34618046-0 2021 CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth. Nitrates 49-56 PEP1 receptor 2 Arabidopsis thaliana 23-38 34523752-6 2021 Sequence analysis revealed three sub-types of AtNPF6.3 orthologs based on their predicted substrate-binding residues: A (chloride selective), B (nitrate selective), and C (legume specific). Nitrates 145-152 nitrate transporter 1.1 Arabidopsis thaliana 46-54 34618046-3 2021 Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN). Nitrates 229-236 calmodulin-like 38 Arabidopsis thaliana 19-37 34618046-3 2021 Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN). Nitrates 229-236 calmodulin-like 38 Arabidopsis thaliana 39-44 34618046-3 2021 Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN). Nitrates 229-236 PEP1 receptor 2 Arabidopsis thaliana 106-121 34618046-3 2021 Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN). Nitrates 229-236 PEP1 receptor 2 Arabidopsis thaliana 123-128 34618046-4 2021 CML38 and PEPR2 are transcriptionally induced by treatments of exogenous nitrate and BR. Nitrates 73-80 calmodulin-like 38 Arabidopsis thaliana 0-5 34618046-4 2021 CML38 and PEPR2 are transcriptionally induced by treatments of exogenous nitrate and BR. Nitrates 73-80 PEP1 receptor 2 Arabidopsis thaliana 10-15 34649677-0 2021 What is the role of the nitrate reductase (euknr) gene in fungi that live in nitrate-free environments? Nitrates 77-84 AWN88_RS04670 Agrobacterium tumefaciens 24-41 34506950-1 2021 Oral microbiota dysbiosis, concomitant with decreased abundance of nitrate (NO3-)-reducing bacteria, oral net nitrite (NO2-) production, and reduced nitric oxide ( NO) bioactivity, is associated with the development of cardiometabolic disorders. Nitrates 67-74 NBL1, DAN family BMP antagonist Homo sapiens 76-79 34656860-0 2021 The Arabidopsis protein NPF6.2/NRT1.4 is a plasma membrane nitrate transporter and a target of protein kinase CIPK23. Nitrates 59-66 Major facilitator superfamily protein Arabidopsis thaliana 24-30 34656860-0 2021 The Arabidopsis protein NPF6.2/NRT1.4 is a plasma membrane nitrate transporter and a target of protein kinase CIPK23. Nitrates 59-66 CBL-interacting protein kinase 23 Arabidopsis thaliana 110-116 34656860-4 2021 Here we show that NPF6.2/NRT1.4, a protein that gates nitrate accumulation at the leaf petiole of Arabidopsis thaliana, also affects the root/shoot distribution of potassium. Nitrates 54-61 Major facilitator superfamily protein Arabidopsis thaliana 18-24 34656860-5 2021 We demonstrate that NPF6.2/NRT1.4 is a plasma membrane nitrate transporter phosphorylated at threonine-98 by the CIPK23 protein kinase that is a regulatory hub for nitrogen and potassium nutrition. Nitrates 55-62 Major facilitator superfamily protein Arabidopsis thaliana 20-26 34656860-5 2021 We demonstrate that NPF6.2/NRT1.4 is a plasma membrane nitrate transporter phosphorylated at threonine-98 by the CIPK23 protein kinase that is a regulatory hub for nitrogen and potassium nutrition. Nitrates 55-62 CBL-interacting protein kinase 23 Arabidopsis thaliana 113-119 34558591-1 2021 A procedure for the formation of a nitrate-encapsulating tripalladium(II) cage via self-assembly of Pd(NO3)2 with 1,3-bis(dimethyl(pyridin-4-yl)silyl)propane (L) was developed. Nitrates 35-42 NBL1, DAN family BMP antagonist Homo sapiens 103-106 34542810-0 2021 Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway. Nitrates 0-7 DNA damage inducible transcript 4 Homo sapiens 81-86 34542810-0 2021 Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway. Nitrates 0-7 AKT serine/threonine kinase 1 Homo sapiens 87-90 34542810-7 2021 However, nitrate could increase cisplatin chemosensitivity, reduce its REDD1 expression, and attenuate AKT signaling activation in OSCC cells. Nitrates 9-16 DNA damage inducible transcript 4 Homo sapiens 71-76 34542810-7 2021 However, nitrate could increase cisplatin chemosensitivity, reduce its REDD1 expression, and attenuate AKT signaling activation in OSCC cells. Nitrates 9-16 AKT serine/threonine kinase 1 Homo sapiens 103-106 34558591-2 2021 The self-assembly reaction initially produces spiro-type macrocycles, PdL2, and finally results in transformation into a nitrate-encapsulated cage, ((NO3)@Pd3L6), in the mother liquor. Nitrates 121-128 programmed cell death 1 ligand 2 Homo sapiens 70-74 34558591-2 2021 The self-assembly reaction initially produces spiro-type macrocycles, PdL2, and finally results in transformation into a nitrate-encapsulated cage, ((NO3)@Pd3L6), in the mother liquor. Nitrates 121-128 NBL1, DAN family BMP antagonist Homo sapiens 150-153 34657263-1 2022 High concentration of nitrate (NO3-) in groundwater is a major concern because of its complex origin and harmful effects on human health. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 31-34 34182389-3 2021 This study examined both the long-term trends in atmospheric nitrogen (N) deposition from the 1990s to the 2010s and the response of stream water nitrate (NO3-) leaching from forested areas in western Japan. Nitrates 146-153 NBL1, DAN family BMP antagonist Homo sapiens 155-158 34581118-14 2021 The delineation of NO3-type waters, especially the low-TDS type, is helpful for identifying groundwaters posing greater risks for human activities, and those with low nitrate concentrations but potential pollution risk, which is of great significance in the prevention and control of groundwater pollution. Nitrates 167-174 NBL1, DAN family BMP antagonist Homo sapiens 19-22 34147777-3 2021 The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively. Nitrates 30-37 solute carrier family 9 member B1 Homo sapiens 131-137 34147777-3 2021 The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively. Nitrates 30-37 solute carrier family 9 member B1 Homo sapiens 188-199 34147777-3 2021 The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively. Nitrates 30-37 solute carrier family 9 member B1 Homo sapiens 308-314 34147777-3 2021 The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively. Nitrates 30-37 solute carrier family 9 member B1 Homo sapiens 364-375 34643825-0 2021 Long-term variation of nitrate in the East Sea, Korea. Nitrates 23-30 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 43-46 34643825-7 2021 Second, decrease in the nitrate flux of the Nakdong River"s estuary due to the construction of the estuary dam and sewer treatment plant could also be a factor for the nitrate decrease in the East Sea. Nitrates 24-31 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 197-200 34643825-7 2021 Second, decrease in the nitrate flux of the Nakdong River"s estuary due to the construction of the estuary dam and sewer treatment plant could also be a factor for the nitrate decrease in the East Sea. Nitrates 168-175 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 197-200 34643825-9 2021 The amount of nitrate runoff reduced by the anthropogenic activities influenced the nitrate levels over a long period by the flow of currents in the East Sea. Nitrates 14-21 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 154-157 34643825-9 2021 The amount of nitrate runoff reduced by the anthropogenic activities influenced the nitrate levels over a long period by the flow of currents in the East Sea. Nitrates 84-91 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 154-157 34180337-8 2021 The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition. Nitrates 183-190 AGAMOUS-like 44 Arabidopsis thaliana 36-40 34677535-0 2021 A Study to Enhance the Nitrate-Nitrogen Removal Rate without Dismantling the NF Module by Building a PFSA Ionomer-Coated NF Module. Nitrates 23-30 neurofascin Homo sapiens 121-123 34180337-8 2021 The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition. Nitrates 183-190 nitrate transporter 1.1 Arabidopsis thaliana 153-159 34180337-8 2021 The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition. Nitrates 183-190 nitrate transporter 1.1 Arabidopsis thaliana 161-165 34228952-9 2021 Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants. Nitrates 52-59 transforming growth factor beta 1 Homo sapiens 23-28 34228952-9 2021 Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants. Nitrates 52-59 solute carrier family 38 member 3 Homo sapiens 29-32 34087531-1 2021 Transport and transformation processes of nitrogen in the soil are an essential part of understanding the relationship between agricultural input and nitrate (NO3-) concentrations in groundwater. Nitrates 150-157 NBL1, DAN family BMP antagonist Homo sapiens 159-162 34388487-9 2021 Our results suggested that the leaf litter treatment was preferential for nitrate reduction over the mud deposit treatment, with a higher NO3- reduction rate and less NH4+ accumulation during the complete BS process. Nitrates 74-81 NBL1, DAN family BMP antagonist Homo sapiens 138-141 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 0-7 solute carrier family 17 member 5 Homo sapiens 23-29 34679685-1 2021 The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Nitrates 17-24 insulin Homo sapiens 117-124 34679685-6 2021 Plasma nitrate, but not nitrite, correlated positively with vegetable intake (r = 0.38, p = 0.018) and was inversely associated with HOMA-IR (r = -0.44, p = 0.006), BMI (r = -0.35, p = 0.028), GGT (r = -0.37, p = 0.019) and CRP (r = -0.34, p = 0.034). Nitrates 7-14 gamma-glutamyltransferase light chain family member 3 Homo sapiens 193-196 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 0-7 solute carrier family 17 member 5 Homo sapiens 115-121 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 107-114 solute carrier family 17 member 5 Homo sapiens 23-29 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 107-114 solute carrier family 17 member 5 Homo sapiens 115-121 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 153-160 solute carrier family 17 member 5 Homo sapiens 23-29 34581269-5 2021 Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis. Nitrates 153-160 solute carrier family 17 member 5 Homo sapiens 115-121 34581269-6 2021 Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue. Nitrates 13-20 epidermal growth factor receptor Homo sapiens 57-89 34581269-6 2021 Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue. Nitrates 13-20 epidermal growth factor receptor Homo sapiens 91-95 34581269-6 2021 Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue. Nitrates 13-20 protein tyrosine kinase 2 beta Homo sapiens 97-113 34581269-6 2021 Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue. Nitrates 13-20 AKT serine/threonine kinase 1 Homo sapiens 115-118 34581269-7 2021 Collectively, nitrate effectively prevented IR-induced xerostomia via the EGFR-AKT-MAPK signaling pathway. Nitrates 14-21 epidermal growth factor receptor Homo sapiens 74-78 34581269-7 2021 Collectively, nitrate effectively prevented IR-induced xerostomia via the EGFR-AKT-MAPK signaling pathway. Nitrates 14-21 AKT serine/threonine kinase 1 Homo sapiens 79-82 34129038-3 2021 Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana. Nitrates 197-204 ILI1 binding bHLH 1 Arabidopsis thaliana 127-131 34129038-3 2021 Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana. Nitrates 197-204 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 133-137 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 27-34 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-4 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 27-34 Plant regulator RWP-RK family protein Arabidopsis thaliana 43-47 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 27-34 NIN like protein 7 Arabidopsis thaliana 52-56 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 89-96 basic helix-loop-helix (bHLH) DNA-binding superfamily protein Arabidopsis thaliana 0-4 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 89-96 Plant regulator RWP-RK family protein Arabidopsis thaliana 43-47 34129038-4 2021 HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling. Nitrates 89-96 NIN like protein 7 Arabidopsis thaliana 52-56 34129038-7 2021 Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2. Nitrates 0-7 NIN like protein 7 Arabidopsis thaliana 54-58 34129038-7 2021 Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2. Nitrates 94-101 NIN like protein 7 Arabidopsis thaliana 54-58 34129038-7 2021 Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2. Nitrates 94-101 cationic amino acid transporter 2 Arabidopsis thaliana 146-150 34129038-7 2021 Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2. Nitrates 94-101 catalase 3 Arabidopsis thaliana 151-155 34129038-8 2021 These results demonstrate that HBI-mediated ROS homeostasis regulates nitrate signal transduction through modulating the nucleocytoplasmic shuttling of NLP7. Nitrates 70-77 NIN like protein 7 Arabidopsis thaliana 152-156 34528820-0 2021 Genome Sequence of Linnemannia hyalina Strain SCG-10, a Cold-Adapted and Nitrate-Reducing Fungus Isolated from Cornfield Soil in Minnesota, USA. Nitrates 73-80 stathmin 2 Homo sapiens 46-52 34549237-1 2021 Through the combination of X-ray structure analysis and density functional theory (DFT) theoretical calculations at the B3LYP-D3/def2-TZVP level of theory, we designed and investigated two novel host units for the recognition of neutral (e.g. halobenzenes) and charged (e.g. chloride and nitrate) guests inspired by a glutamate carboxypeptidase II (GCPII) system and its inhibitors. Nitrates 288-295 folate hydrolase 1 Homo sapiens 318-347 34549237-1 2021 Through the combination of X-ray structure analysis and density functional theory (DFT) theoretical calculations at the B3LYP-D3/def2-TZVP level of theory, we designed and investigated two novel host units for the recognition of neutral (e.g. halobenzenes) and charged (e.g. chloride and nitrate) guests inspired by a glutamate carboxypeptidase II (GCPII) system and its inhibitors. Nitrates 288-295 folate hydrolase 1 Homo sapiens 349-354 34528820-1 2021 We report here the genome sequence of Linnemannia hyalina strain SCG-10, a cold-adapted and nitrate-reducing fungus isolated from soil. Nitrates 92-99 stathmin 2 Homo sapiens 65-71 34357701-0 2021 Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture. Nitrates 0-7 Auxin efflux carrier family protein Arabidopsis thaliana 48-52 34519758-0 2021 Electrocatalytic nitrate reduction with Co-based catalysts: comparison of DIM, TIM and cyclam ligands. Nitrates 17-24 Rho guanine nucleotide exchange factor 5 Homo sapiens 79-82 34357701-6 2021 The phosphorylation profile of NITRATE TRANSPORTER 1.1 (NRT1.1) mutant plants was significantly altered as compared to wild-type plants, confirming its key role in nitrate signaling pathways that involves phosphorylation changes. Nitrates 164-171 nitrate transporter 1.1 Arabidopsis thaliana 31-54 34357701-6 2021 The phosphorylation profile of NITRATE TRANSPORTER 1.1 (NRT1.1) mutant plants was significantly altered as compared to wild-type plants, confirming its key role in nitrate signaling pathways that involves phosphorylation changes. Nitrates 164-171 nitrate transporter 1.1 Arabidopsis thaliana 56-62 34357701-8 2021 We validated a new phosphorylation site in PIN2 and provide evidence that it functions in primary and lateral root growth responses to nitrate. Nitrates 135-142 Auxin efflux carrier family protein Arabidopsis thaliana 43-47 34075592-3 2021 This raises the question of why nitrate may or may not be present in phloem sap, why its concentration is generally kept low, and whether plant shoot-root nutrient cycling also involves nitrate. Nitrates 32-39 SH2 domain containing 1A Homo sapiens 76-79 34089542-3 2021 By investigating moss N contents and delta15 N values in southwestern China in 1954-1964, 1970-1994, and 2005-2015, we reconstructed fluxes and source contributions of atmospheric ammonium (NH4 + ) and nitrate (NO3 - ) deposition and their historical changes. Nitrates 202-209 NBL1, DAN family BMP antagonist Homo sapiens 211-214 34155644-5 2021 Also, dissolution - being microbially-mediated - would be buffered by the presence of nitrate (NO3 - ), which is a preferable electron acceptor than Fe and Mn in microbial reactions. Nitrates 86-93 NBL1, DAN family BMP antagonist Homo sapiens 95-98 34147727-8 2021 Nitrate decrease MDA by reducing the activities of superoxide dismutase, peroxidase, and catalase in root of the N-efficient genotype. Nitrates 0-7 peroxidase A2 Brassica napus 73-83 34147727-8 2021 Nitrate decrease MDA by reducing the activities of superoxide dismutase, peroxidase, and catalase in root of the N-efficient genotype. Nitrates 0-7 catalase-3-like Brassica napus 89-97 34198052-5 2021 At long-term, nitrate reductase (SlNR) and nitrite reductase (SlNIR) expression were not significantly different between nitrate treatments in RO, while significantly down-regulated under nitrate limiting treatment in UC82. Nitrates 188-195 nitrite reductase Solanum lycopersicum 43-60 34477653-3 2021 In this study, a novel zeolitic imidazolate framework-8 film engineered bismuth nanosheet electrocatalyst (ZIF-8/Bi-CC) was designed and synthesized for the electrochemical reduction of nitrate. Nitrates 186-193 Bicaudal C Drosophila melanogaster 113-118 34074412-5 2021 In order to demonstrate applicability of the method, label free SERS measurements of nitrate ion was performed on the proposed sensing platform. Nitrates 85-92 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 64-68 34578546-2 2021 In this paper, Sm3+ and Nd3+ co-doped CeO2 (SNDC) and pure CeO2 are synthesized via glycine-nitrate process (GNP) and the electro-chemical properties of the nanocrystalline structure electrolyte are investigated using complementary techniques. Nitrates 92-99 mitochondrially encoded NADH dehydrogenase 3 Homo sapiens 24-27 34477653-7 2021 More importantly, the final nitrate removal rate of ZIF-8/Bi-CC was close to 90% after 5 h when treating actual garbage fly ash wastewater, the NITRR efficiency stability and the obtained product were confirmed by five electrochemical cycles. Nitrates 28-35 Bicaudal C Drosophila melanogaster 58-63 34497626-0 2021 NRT1.1 Dual-Affinity Nitrate Transport/Signalling and its Roles in Plant Abiotic Stress Resistance. Nitrates 21-28 immunoglobulin superfamily member 9 Homo sapiens 0-4 34410136-1 2021 Nitrate (NO3-) reduction reaction (NtRR) is considered as a green alternative method for the conventional method of NH3 synthesis (Haber-Bosch process), which is known as a high energy consuming and large CO2 emitting process. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34440751-7 2021 The current literature suggests that ROS/RNS nitrate proNGF and reduce the expression of the proNGF receptor tropomyosin-related kinase A (TrkA), disrupting its downstream survival signalling. Nitrates 45-52 neurotrophic receptor tyrosine kinase 1 Homo sapiens 139-143 34408222-1 2021 Nitrate (NO3-) pollution is a serious global problem, and the quantitative analysis of its sources contributions is essential for devising effective water-related environmental-protection policies. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 34421841-1 2021 Woodchip bioreactors are increasingly used to remove nitrate (NO3 -) from agricultural drainage water in order to protect aquatic ecosystems from excess nitrogen. Nitrates 53-60 NBL1, DAN family BMP antagonist Homo sapiens 62-65 34161745-8 2021 The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking. Nitrates 4-11 delta like non-canonical Notch ligand 1 Homo sapiens 72-78 34161745-8 2021 The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking. Nitrates 4-11 delta like non-canonical Notch ligand 1 Homo sapiens 125-131 34161745-8 2021 The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking. Nitrates 4-11 delta like non-canonical Notch ligand 1 Homo sapiens 139-145 34124878-0 2021 Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction. Nitrates 117-124 mitochondrially encoded cytochrome c oxidase III Homo sapiens 22-29 34309015-6 2021 In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function. Nitrates 114-121 xanthine dehydrogenase Mus musculus 176-199 34309015-6 2021 In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function. Nitrates 114-121 xanthine dehydrogenase Mus musculus 201-204 34264986-10 2021 By adding supplementary LED lamps into the EAS, the soluble sugar content of lettuce increased by 72.14% and the nitrate content of lettuce decreased by 21.51%. Nitrates 113-120 small integral membrane protein 10 like 2A Homo sapiens 24-27 34276717-0 2021 Growth Performance Can Be Increased Under High Nitrate and High Salt Stress Through Enhanced Nitrate Reductase Activity in Arabidopsis Anthocyanin Over-Producing Mutant Plants. Nitrates 47-54 nitrate reductase 1 Arabidopsis thaliana 93-110 34276717-3 2021 However, excessive nitrogen use has an enormous negative impact on ecosystems and human health through the emission of intense greenhouse gases, such as nitric oxide derived from the nitrate (NO3 -) assimilation cascade. Nitrates 183-190 NBL1, DAN family BMP antagonist Homo sapiens 192-195 34209142-1 2021 The objective of the study was to gather insight into the metabolism of lead-removing microorganisms, coupled with Pb(II) removal, biomass viability and nitrate concentrations for Pb(II) bioremoval using an industrially obtained microbial consortium. Nitrates 153-160 submaxillary gland androgen regulated protein 3B Homo sapiens 180-186 34235267-1 2021 A combined technique of production and storage of ammonia (NH3) from electroreduction of nitrate (NO3 -) through one material is highly desirable but remains a huge challenge. Nitrates 89-96 NBL1, DAN family BMP antagonist Homo sapiens 98-101 34124878-0 2021 Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction. Nitrates 117-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 34-40 34207422-1 2021 Denitrifying woodchip bioreactors (WBR), which aim to reduce nitrate (NO3-) pollution from agricultural drainage water, are less efficient when cold temperatures slow down the microbial transformation processes. Nitrates 61-68 NBL1, DAN family BMP antagonist Homo sapiens 70-73 34086442-4 2021 The uptake process of NO2 on OA gives HONO as a reaction product, and the highest HONO production was observed upon the heterogeneous reaction of NO2 with OA in the presence of nitrate (NO3-) ions. Nitrates 177-184 NBL1, DAN family BMP antagonist Homo sapiens 186-189 34208733-1 2021 A direct, reagent-free, ultraviolet spectroscopic method for the simultaneous determination of nitrate (NO3-), nitrite (NO2-), and salinity in seawater is presented. Nitrates 95-102 NBL1, DAN family BMP antagonist Homo sapiens 104-107 34114114-11 2021 With a combined change in climate and land cover, the annual nitrate concentrations are expected to increase by + 19.7% and + 17.9%, under RCP 4.5 and RCP 8.5, respectively. Nitrates 61-68 CGRP receptor component Homo sapiens 139-142 34198661-4 2021 The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise. Nitrates 14-21 catalase Homo sapiens 116-124 34198661-4 2021 The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise. Nitrates 14-21 mitofusin 2 Homo sapiens 172-183 34198661-4 2021 The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise. Nitrates 14-21 PPARG coactivator 1 alpha Homo sapiens 188-197 34198661-5 2021 The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake. Nitrates 195-202 catalase Homo sapiens 23-31 34198661-5 2021 The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake. Nitrates 195-202 tumor necrosis factor Homo sapiens 36-44 34114114-11 2021 With a combined change in climate and land cover, the annual nitrate concentrations are expected to increase by + 19.7% and + 17.9%, under RCP 4.5 and RCP 8.5, respectively. Nitrates 61-68 CGRP receptor component Homo sapiens 151-154 34275783-1 2021 To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF). Nitrates 56-63 energy homeostasis associated Homo sapiens 83-90 34193742-3 2021 However, NO is divided into two fractions, nitrite (NO2) and nitrate (NO3), which appear to play different roles in epileptogenesis. Nitrates 61-68 NBL1, DAN family BMP antagonist Mus musculus 70-73 34275783-1 2021 To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF). Nitrates 56-63 natriuretic peptide B Homo sapiens 95-120 34275783-1 2021 To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF). Nitrates 56-63 natriuretic peptide B Homo sapiens 122-125 34264555-3 2021 The aim of the work was to study the levels of nitrate contamination of CP and assess the associated risk to the health of children and adults in the Baikal Region. Nitrates 47-54 ceruloplasmin Homo sapiens 72-74 35576711-1 2022 Researchers have long been committed to identify nitrate sources in groundwater and to develop an advanced technique for its remediation because better apply remediation solution and management of water quality is highly dependent on the identification of the NO3- sources contamination in water. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 260-263 35472551-8 2022 CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water. Nitrates 153-157 mitogen-activated protein kinase kinase kinase 7 Homo sapiens 0-4 35525348-3 2022 Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process. Nitrates 32-39 NBL1, DAN family BMP antagonist Homo sapiens 71-74 35525348-3 2022 Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 71-74 35525348-3 2022 Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 89-92 35525348-3 2022 Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 116-119 35525348-3 2022 Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process. Nitrates 107-114 NBL1, DAN family BMP antagonist Homo sapiens 319-322 35271927-5 2022 We quantified the effects of colder, surface water temperature on the nitrate (NO3-) reduction rate in vegetated marsh and open water bay sediments. Nitrates 70-77 NBL1, DAN family BMP antagonist Homo sapiens 79-82 35472839-0 2022 APCS-MLR model: A convenient and fast method for quantitative identification of nitrate pollution sources in groundwater. Nitrates 80-87 amyloid P component, serum Homo sapiens 0-4 35202681-4 2022 Five years (2015-2020) of water quantity and quality data from 11 agricultural watersheds in southern Ontario were used to develop GAMs to predict total phosphorus (TP) and nitrate (NO3-) loads. Nitrates 173-180 NBL1, DAN family BMP antagonist Homo sapiens 182-185 35568027-4 2022 Surprisingly, avirulent S. Typhimurium was shown to be unable to utilize epithelial-derived nitrate because its chemotaxis receptors McpB and McpC exclude the pathogen from the niche occupied by E. coli. Nitrates 92-99 hlyB-like ABC transporter-like protein Escherichia coli 133-137 35019185-3 2022 Simulated fluxes include microbial immobilization and plant uptake, which compete with nitrification and denitrification, respectively, for available soil ammonium (NH4 + ) and nitrate (NO3 - ). Nitrates 177-184 NBL1, DAN family BMP antagonist Homo sapiens 186-189 35157864-5 2022 Transcriptome analysis of mouse lungs exposed to nitrate/sulfate aerosols reveals interferon gamma-associated immune response. Nitrates 49-56 interferon gamma Mus musculus 82-98 35227848-1 2022 Nitrate (NO3-) pollution in water bodies has received widespread attention, but studies on nitrogen transformation and pollution risk assessment are still limited, especially in rare earth mining areas. Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 9-12 35243632-0 2022 NLP1 binds the CEP1 signalling peptide promoter to repress its expression in response to nitrate. Nitrates 89-96 nucleoporin 42 Homo sapiens 0-4 35243632-0 2022 NLP1 binds the CEP1 signalling peptide promoter to repress its expression in response to nitrate. Nitrates 89-96 centriolin Homo sapiens 15-19 35398714-5 2022 Consumption of nitrate partially preserved glucose tolerance and, within skeletal muscle, normalized insulin-induced Akt phosphorylation, mitochondrial ADP sensitivity, mtH2O2, protein carbonylation and global mitochondrial acetylation status. Nitrates 15-22 thymoma viral proto-oncogene 1 Mus musculus 117-120 35150690-5 2022 The plotting of delta15N-NO3- versus NO3-/Cl- ratios also supported the assumption that sewage is the dominant nitrate source. Nitrates 111-118 NBL1, DAN family BMP antagonist Homo sapiens 37-40 35398714-6 2022 Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate. Nitrates 0-7 sirtuin 1 Mus musculus 53-58 35398714-6 2022 Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate. Nitrates 111-118 sirtuin 1 Mus musculus 53-58 35398714-6 2022 Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate. Nitrates 111-118 sirtuin 1 Mus musculus 207-212 35398714-6 2022 Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate. Nitrates 111-118 sirtuin 1 Mus musculus 250-255 35398714-7 2022 Altogether, dietary nitrate preserves mitochondrial ADP sensitivity and global lysine acetylation in HFD-fed mice, while in the absence of SIRT1, the effects of nitrate on glucose tolerance and mitochondrial acetylation were abrogated. Nitrates 161-168 sirtuin 1 Mus musculus 139-144 35604567-3 2022 Moreover, there is no consensus on the safe administration of dietary nitrate as an ergogenic aid. Nitrates 70-77 activation induced cytidine deaminase Homo sapiens 94-97 35421667-1 2022 If we can use toxic aromatic compounds as supplementary carbon source, the simultaneous removal of nitrate (NO3-) and aromatic compounds may be achieved at much lower chemical costs. Nitrates 99-106 NBL1, DAN family BMP antagonist Homo sapiens 108-111 35614500-1 2022 In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out. Nitrates 150-157 transmembrane protein 37 Homo sapiens 109-116 35614500-1 2022 In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out. Nitrates 150-157 transmembrane protein 37 Homo sapiens 121-124 35614500-1 2022 In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out. Nitrates 150-157 transmembrane protein 37 Homo sapiens 132-135 35604567-17 2022 The effects of dietary nitrate appear to be diminished in individuals with a higher aerobic fitness (peak oxygen consumption (VO2peak) > 60 ml/kg/min), and therefore, aerobic fitness should be taken into account when considering use of dietary nitrate as an ergogenic aid. Nitrates 23-30 activation induced cytidine deaminase Homo sapiens 268-271 35573269-6 2022 In particular, in the CS range from 0.02 to 0.03 s-1, the nitrate fraction was 17% on NPF event days and 26% on non-NPF event days. Nitrates 58-65 citrate synthase Homo sapiens 22-24 35583665-2 2022 The global increases in the surface and groundwater nitrate (NO3 - ) concentrations due to synthetic fertilizer input have emerged as major sustainability threats to terrestrial and aquatic ecosystems. Nitrates 52-59 NBL1, DAN family BMP antagonist Homo sapiens 61-64 35579458-7 2022 Compared to oxic (>60 muM O2) Tara Ocean and high-hypoxic (>20 to <=60 muM O2) BoB samples, we found more SAR11-nar sequences (responsible for reducing nitrate to nitrite) in low-hypoxic (>5 to <=20 muM O2) BoB waters. Nitrates 152-159 G protein-coupled receptor 15 Homo sapiens 79-82 35579458-7 2022 Compared to oxic (>60 muM O2) Tara Ocean and high-hypoxic (>20 to <=60 muM O2) BoB samples, we found more SAR11-nar sequences (responsible for reducing nitrate to nitrite) in low-hypoxic (>5 to <=20 muM O2) BoB waters. Nitrates 152-159 G protein-coupled receptor 15 Homo sapiens 207-210 35579458-9 2022 It seems that the nitrite-N was not further reduced to nitrogen through denitrification but likely oxidized to nitrate by Nitrospinae in the BoB OMZ and then accumulated in the form of nitrate-N. Nitrates 111-118 G protein-coupled receptor 15 Homo sapiens 141-144 35579458-11 2022 Together, these results suggested that reduction of oxygen concentration and OMZ expansion may increase the use of nitrate by SAR11 and N2 production in the BoB. Nitrates 115-122 G protein-coupled receptor 15 Homo sapiens 157-160 35149011-3 2022 The existence of nitrate in general decreased TCE dechlorination efficiency to varying degrees, and the higher nitrate concentration, the stronger the inhibitory effects, verified by the gradually decreased transcription levels of tceA. Nitrates 17-24 transcription elongation factor A1 Homo sapiens 231-235 35233916-3 2022 Herein, a modification of nitrate ion (NO3 - ) is proposed and validated to improve the homogeneity of the SEI in practical LMBs. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 39-42 35351554-5 2022 Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3. Nitrates 46-53 phenylalanine hydroxylase Homo sapiens 250-252 35351554-5 2022 Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3. Nitrates 139-146 phenylalanine hydroxylase Homo sapiens 250-252 35149011-3 2022 The existence of nitrate in general decreased TCE dechlorination efficiency to varying degrees, and the higher nitrate concentration, the stronger the inhibitory effects, verified by the gradually decreased transcription levels of tceA. Nitrates 111-118 transcription elongation factor A1 Homo sapiens 231-235 35192730-9 2022 The biopterin, BH4, and norepinephrine contents were increased in penile homogenates from BH4-supplemented Spr-/- mice, and the TH protein levels tended to increase, and their nitrite plus nitrate levels were significantly lower than those of vehicle-treated Spr-/- mice and were approximately the same as vehicle- and BH4-supplemented Spr+/+ mice. Nitrates 189-196 sepiapterin reductase Mus musculus 107-110 35065174-0 2022 Enhanced bioremediation of RDX and Co-Contaminants perchlorate and nitrate using an anaerobic dehalogenating consortium in a fractured rock aquifer. Nitrates 67-74 radixin Homo sapiens 27-30 35065174-2 2022 Bioremediation of RDX is feasible through biostimulation of native microbes with an organic carbon donor but may be less efficient, or not occur at all, in the presence of the common co-contaminants perchlorate and nitrate. Nitrates 215-222 radixin Homo sapiens 18-21 35065174-7 2022 In microcosms with groundwater containing perchlorate and nitrate, RDX degradation began without delay when bioaugmented with 10% WBC-2. Nitrates 58-65 radixin Homo sapiens 67-70 35240317-1 2022 Exercise tolerance appears to benefit most from dietary nitrate (NO3-) supplementation when muscle oxygen (O2) availability is low. Nitrates 56-63 NBL1, DAN family BMP antagonist Homo sapiens 65-68 35417808-7 2022 Furthermore, the NO3-/Cl- versus Cl- diagram and principal component analysis (PCA) indicated nitrate pollution in groundwater that is subjected to anthropogenic activities such as domestic sewage, agricultural and industrial practices, which lead to degradation of groundwater quality in the area. Nitrates 94-101 NBL1, DAN family BMP antagonist Homo sapiens 17-20 35240317-6 2022 Nitrate supplementation increased plasma NO3- (16.2-fold) and NO2- (4.2-fold) and time to volitional fatigue (61.8 +- 56.5 s longer duration vs. placebo visit; p = 0.03). Nitrates 0-7 NBL1, DAN family BMP antagonist Homo sapiens 41-44 35038503-3 2022 A higher PM1 mass concentration (63.0 mug m-3) was observed in an industrially influenced district (XG) with major contributions (70.4%) from three secondary inorganic species (sulfate, nitrate, and ammonium) and two oxygenated organic aerosol (OOA) components with different oxygenation levels. Nitrates 186-193 transmembrane protein 11 Homo sapiens 9-12 35038503-6 2022 The chemical formation mechanisms of secondary PM1 species in the two different districts during the daytime and nighttime are further examined, which indicated the important photochemical formations of nitrate in CG but sulfate in XG during the daytime, whereas favorable aqueous-phase formations of nitrate and LO-OOA in both districts during the nighttime. Nitrates 203-210 transmembrane protein 11 Homo sapiens 47-50 35038503-6 2022 The chemical formation mechanisms of secondary PM1 species in the two different districts during the daytime and nighttime are further examined, which indicated the important photochemical formations of nitrate in CG but sulfate in XG during the daytime, whereas favorable aqueous-phase formations of nitrate and LO-OOA in both districts during the nighttime. Nitrates 301-308 transmembrane protein 11 Homo sapiens 47-50 35041959-5 2022 Ship emitted single particles contain organic carbon (OC), elemental carbon (EC), metals, sulfate and nitrate. Nitrates 102-109 inositol polyphosphate-5-phosphatase D Homo sapiens 0-4 35146519-2 2022 In Lotus japonicus, two NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors, LjNLP4 and LjNLP1, play pivotal roles in the negative regulation of nodulation by controlling the expression of symbiotic genes in high nitrate conditions. Nitrates 225-232 NLP1 Lotus japonicus 100-106 35217293-0 2022 Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway. Nitrates 10-17 thymoma viral proto-oncogene 1 Mus musculus 147-150 35217293-0 2022 Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway. Nitrates 10-17 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 151-160 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrates 30-37 thymoma viral proto-oncogene 1 Mus musculus 128-131 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrates 30-37 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 141-209 35217293-11 2022 Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function. Nitrates 30-37 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 211-220 35254167-6 2022 The microbial consortia in B. glabrata helped in the digestion of complex polysaccharide such as starch, hemicellulose, and chitin for energy supply, and protected the snail from food poisoning and nitrate toxicity. Nitrates 198-205 snail family transcriptional repressor 1 Homo sapiens 168-173 35146519-6 2022 LjNLP1 is necessary and sufficient to induce LjNRT2.1 expression, thereby regulating nitrate uptake/transport. Nitrates 85-92 NLP1 Lotus japonicus 0-6 35146519-8 2022 We further show that LjNIN, a positive regulator of nodulation, counteracts the LjNLP1-dependent induction of LjNRT2.1 expression, which is linked to a reduction in nitrate uptake. Nitrates 165-172 nin Lotus japonicus 21-26 35146519-8 2022 We further show that LjNIN, a positive regulator of nodulation, counteracts the LjNLP1-dependent induction of LjNRT2.1 expression, which is linked to a reduction in nitrate uptake. Nitrates 165-172 NLP1 Lotus japonicus 80-86 35394760-2 2022 In this work, FeOOH nanorod with intrinsic oxygen vacancy supported on carbon paper (FeOOH/CP) is proposed as a high-performance electrocatalyst for converting nitrate to ammonia at room temperature. Nitrates 160-167 ceruloplasmin Homo sapiens 91-93 35357149-0 2022 Arc-Induced Nitrate Reagent Ion for Analysis of Trace Explosives on Surfaces Using Atmospheric Pressure Arc Desorption/Ionization Mass Spectrometry. Nitrates 12-19 activity regulated cytoskeleton associated protein Homo sapiens 0-3 35436155-2 2022 OBJECTIVE: To measure temporal trends in the coprescription of nitrates and PDE5 inhibitors and to measure the association between cardiovascular outcomes and the coprescription of nitrates with PDE5 inhibitors. Nitrates 181-189 phosphodiesterase 5A Homo sapiens 195-199 35436155-9 2022 During this period, the prescription rate for PDE5 inhibitors in patients with IHD who were taking nitrates increased from an average of 0.9 prescriptions (95% CI, 0.5 to 1.2 prescriptions) per 100 persons per year in 2000 to 19.5 prescriptions (CI, 18.0 to 21.1 prescriptions) in 2018. Nitrates 99-107 phosphodiesterase 5A Homo sapiens 46-50 35436155-12 2022 CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. Nitrates 123-131 phosphodiesterase 5A Homo sapiens 42-46 35357149-0 2022 Arc-Induced Nitrate Reagent Ion for Analysis of Trace Explosives on Surfaces Using Atmospheric Pressure Arc Desorption/Ionization Mass Spectrometry. Nitrates 12-19 activity regulated cytoskeleton associated protein Homo sapiens 104-107 35357149-2 2022 In APADI, neutral explosives readily bind to the gas-phase nitrate ion, NO3-, induced by arc discharge to form anionic adducts (M+NO3)-. Nitrates 59-66 activity regulated cytoskeleton associated protein Homo sapiens 89-92 35229477-1 2022 Ammonium (NH4 + ) and nitrate (NO3 - ) are major inorganic nitrogen (N) source for plants. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 31-34 35392923-8 2022 The functionality of the NOS2-2 protein was analyzed by transient transfection of expression clones in human DLD1 cells and nitrate measurement in the supernatant of these cells. Nitrates 124-131 nitric oxide synthase 2 Homo sapiens 25-31 35299236-1 2022 Electrocatalytic nitrate (NO3-) reduction not only generates high-value ammonia (NH3) but holds significant potential in the control of NO3- contaminants in natural environments. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 26-29 35299236-1 2022 Electrocatalytic nitrate (NO3-) reduction not only generates high-value ammonia (NH3) but holds significant potential in the control of NO3- contaminants in natural environments. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 136-139 35459501-7 2022 The formation of nitrate at night mainly originated from N2O5 uptake, and the maximum production rate of NO3- reached 6.5 ppbv/hr. Nitrates 17-24 NBL1, DAN family BMP antagonist Homo sapiens 105-108 35229477-3 2022 NO3 - usually causes no toxicity and can mitigate ammonium toxicity even at low concentrations, referring to as nitrate-dependent alleviation of ammonium toxicity. Nitrates 112-119 NBL1, DAN family BMP antagonist Homo sapiens 0-3 35459501-9 2022 The predominant roles of NO3 and N2O5 in nitrate formation and NOx removal in the YRD region was highlighted in this study. Nitrates 41-48 NBL1, DAN family BMP antagonist Homo sapiens 25-28 35229477-11 2022 Our study thus revealed NRT1.1 and SLAH3 form a functional unit to regulate nitrate-dependent alleviation of ammonium toxicity through regulating NO3 - transport and balancing rhizosphere acidification. Nitrates 76-83 NBL1, DAN family BMP antagonist Homo sapiens 146-149 35357062-5 2022 We demonstrated distinct salt stress resistance between Ler and Col-0 depending on the differences in nitrate level, which was explained by different regulation of the NIA2 gene expression in these two ecotypes. Nitrates 102-109 nitrate reductase 2 Arabidopsis thaliana 168-172 35365707-1 2022 Changes in the aerosol composition of sulfate (SO42-) and nitrate (NO3-) from 2012 to 2019 have been captured as a paradigm shift in the region downwind of China. Nitrates 58-65 NBL1, DAN family BMP antagonist Homo sapiens 67-70 35355184-0 2022 Identification of sources and transformations of nitrate in Cr(VI)-impacted alluvial aquifers by a hydrogeochemical and delta15N-NO3- and delta18O-NO3 - isotopes approach. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 129-132 35355184-0 2022 Identification of sources and transformations of nitrate in Cr(VI)-impacted alluvial aquifers by a hydrogeochemical and delta15N-NO3- and delta18O-NO3 - isotopes approach. Nitrates 49-56 NBL1, DAN family BMP antagonist Homo sapiens 147-150 35348891-1 2022 MAIN CONCLUSION: The local and long-distance signaling pathways mediated by the leucine-rich repeat receptor kinase HAR1 suppress root branching and promote primary root length in response to nitrate supply. Nitrates 192-199 CM0216.560.nc Lotus japonicus 116-120 35352014-1 2022 BACKGROUND/OBJECTIVES: To compare the effects of supplemental inorganic nitrate (NO3) on microvascular endothelial function and blood pressure in younger vs. older participants. Nitrates 72-79 NBL1, DAN family BMP antagonist Homo sapiens 81-84 35348891-7 2022 We show that the har1 mutant exhibits high nitrate sensitivity during root development. Nitrates 43-50 CM0216.560.nc Lotus japonicus 17-21 35348891-8 2022 The uninfected har1 mutant significantly increased lateral root number and reduced primary root length in the presence of 3 mM nitrate, compared with the wild-type and tml mutant. Nitrates 127-134 CM0216.560.nc Lotus japonicus 15-19 35348891-9 2022 Grafting experiments indicated that local and long-distance signaling pathways via root- and shoot-acting HAR1 additively regulated root morphology under the moderate nitrate concentrations. Nitrates 167-174 CM0216.560.nc Lotus japonicus 106-110 35348891-10 2022 These findings allow us to propose that HAR1-mediated signaling pathways control the root system architecture by suppressing lateral root branching and promoting primary root elongation in response to nitrate availability. Nitrates 201-208 CM0216.560.nc Lotus japonicus 40-44 35293417-3 2022 Inorganic nitrate is a ubiquitous component of atmospheric aqueous phases such as cloudwater, fog, and aqueous aerosols. Nitrates 10-17 zinc finger protein, FOG family member 1 Homo sapiens 94-97 35364374-5 2022 However, the application of Se at 4 and 16 mumol L-1, prompted a relief of this stress, reducing both lipid peroxidation and the sugar content, and increasing the nitrate concentration. Nitrates 163-170 squalene epoxidase Homo sapiens 28-30 35364374-6 2022 In addition, in the case of the highest concentration of Se (16 mumol L-1), the values of nitrate were comparable those control plants. Nitrates 90-97 squalene epoxidase Homo sapiens 57-59 34978758-1 2022 The electrocatalytic nitrate-to-ammonia reduction reaction route (NARR) is one of the emerging routes toward the green ammonia synthesis, and its conversion efficiency is controlled mainly by the hydrogenation selectivity. Nitrates 21-28 ras-related protein Rab-34 Homo sapiens 66-70 35360239-2 2022 This study investigates if performance at simulated altitude is improved to a larger extent when high-intensity interval training is performed in normobaric hypoxia and if this is potentiated when combined with chronic dietary nitrate (NO3 -) supplementation. Nitrates 227-234 NBL1, DAN family BMP antagonist Homo sapiens 236-239 35424754-4 2022 To have a better understanding of the structure-property relationships of furazan-bicyclic scaffolds and nitrate groups, their thermal behaviors, detonation performances and the sensitivities were investigated via differential scanning calorimetry (DSC), ESP analysis, Hirshfeld surfaces calculation, EXPLO5 program and BAM standard techniques. Nitrates 105-112 protein tyrosine phosphatase receptor type V, pseudogene Homo sapiens 255-258 35263337-8 2022 Using RNA sequencing analysis and in vitro biochemical experiment, we found NAC056 regulated the expression of genes required for NO3- assimilation, directly targeting the key nitrate assimilation gene NIA1. Nitrates 176-183 nitrate reductase 1 Arabidopsis thaliana 202-206 35263337-9 2022 In addition, mutation of NIA1 suppresses LR development and nitrate deficiency tolerance in the 35S::NAC056 transgenic plants. Nitrates 60-67 nitrate reductase 1 Arabidopsis thaliana 25-29 35150744-5 2022 In each of these two cases, the maximum amount of nitrite or nitrate formed was at best stoichiometric with the concentration of Mka HLP. Nitrates 61-68 HLP Homo sapiens 133-136 35235063-2 2022 The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 38-41 35235063-2 2022 The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 198-201 35235063-2 2022 The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China. Nitrates 29-36 NBL1, DAN family BMP antagonist Homo sapiens 216-219 35241877-6 2022 Nitrate losses at landscape scale increased during the 2019-2020 extreme wet-weather period to 2.04-4.54 kg ha-1. Nitrates 0-7 Rho GTPase activating protein 45 Homo sapiens 108-112 35007932-0 2022 Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway. Nitrates 9-16 serine/threonine kinase 11 Homo sapiens 117-121 34998066-7 2022 Within 2 h of electrolysis, Cu/MWVNT/FTO exhibits more than 65% removal of nitrate at -1.80 V (vs. SCE). Nitrates 75-82 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 37-40 34998066-13 2022 Compared to earlier systems, the Cu/MWCNT/FTO is environmentally stable, safe, non-costly with high nitrate removal efficiency and selectivity. Nitrates 100-107 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 42-45 35007932-0 2022 Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway. Nitrates 9-16 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 122-126 34787344-1 2022 RATIONALE: Analyses of the isotope ratios of nitrogen (15 N/14 N) and oxygen (18 O/16 O) in nitrate (NO3 - ) with the denitrifier method require relatively high sample volumes at low concentrations (<= 1 muM) to afford sufficient analyte for mass spectrometry, resulting in isotopic offsets compared to more concentrated samples of the same isotopic composition. Nitrates 92-99 NBL1, DAN family BMP antagonist Homo sapiens 101-104 35128037-8 2022 The wastewater analyses confirm the occurrence of nitrate (NO3 -), nitrite (NO2 -), and ammonia (NH4 +), which provide an appropriate condition for NO2 release. Nitrates 50-57 NBL1, DAN family BMP antagonist Homo sapiens 59-62 35391922-2 2022 At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite. Nitrates 239-246 nitric oxide synthase 2 Homo sapiens 89-100 35101982-2 2022 The electrochemical nitrate reduction reaction (NO3 -RR) is a promising approach for nitrate removal and NH3 production at ambient conditions, but efficient electrocatalysts are lacking. Nitrates 20-27 NBL1, DAN family BMP antagonist Homo sapiens 48-51 35101982-2 2022 The electrochemical nitrate reduction reaction (NO3 -RR) is a promising approach for nitrate removal and NH3 production at ambient conditions, but efficient electrocatalysts are lacking. Nitrates 85-92 NBL1, DAN family BMP antagonist Homo sapiens 48-51 35161943-2 2022 The first nitrate transporter activity biosensor NiTrac1 converted the dual-affinity nitrate transceptor NPF6.3 into fluorescence activity sensors. Nitrates 10-17 nitrate transporter 1.1 Arabidopsis thaliana 105-111 35161943-2 2022 The first nitrate transporter activity biosensor NiTrac1 converted the dual-affinity nitrate transceptor NPF6.3 into fluorescence activity sensors. Nitrates 85-92 nitrate transporter 1.1 Arabidopsis thaliana 105-111 35067307-0 2022 Overexpression of tomato thioredoxin h (SlTrxh) enhances excess nitrate stress tolerance in transgenic tobacco interacting with SlPrx protein. Nitrates 64-71 thioredoxin-like protein CITRX, chloroplastic Solanum lycopersicum 25-36 35046022-0 2022 Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate. Nitrates 87-94 abscisic acid responsive elements-binding factor 2 Arabidopsis thaliana 35-39 34545936-3 2022 In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression. Nitrates 86-93 transcription regulatory protein SNF2 Arabidopsis thaliana 56-59 34545936-3 2022 In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression. Nitrates 86-93 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 75-78 34545936-3 2022 In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression. Nitrates 86-93 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 105-130 34545936-3 2022 In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression. Nitrates 86-93 GATA type zinc finger transcription factor family protein Arabidopsis thaliana 135-139 35046022-0 2022 Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate. Nitrates 87-94 abscisic acid responsive elements-binding factor 3 Arabidopsis thaliana 44-48 35046022-8 2022 Validated targets of ABF2 and ABF3 account for more than 50% of the nitrate-responsive transcriptome in the endodermis. Nitrates 68-75 abscisic acid responsive elements-binding factor 2 Arabidopsis thaliana 21-25 35046022-8 2022 Validated targets of ABF2 and ABF3 account for more than 50% of the nitrate-responsive transcriptome in the endodermis. Nitrates 68-75 abscisic acid responsive elements-binding factor 3 Arabidopsis thaliana 30-34 35046022-9 2022 Moreover, ABF2 and ABF3 are involved in nitrate-induced lateral root growth. Nitrates 40-47 abscisic acid responsive elements-binding factor 2 Arabidopsis thaliana 10-14 35046022-9 2022 Moreover, ABF2 and ABF3 are involved in nitrate-induced lateral root growth. Nitrates 40-47 abscisic acid responsive elements-binding factor 3 Arabidopsis thaliana 19-23 35140727-4 2021 Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism. Nitrates 128-135 NIN like protein 7 Arabidopsis thaliana 24-61 35140727-8 2021 Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity. Nitrates 64-71 NIN like protein 7 Arabidopsis thaliana 6-10 35140727-4 2021 Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism. Nitrates 128-135 NIN like protein 7 Arabidopsis thaliana 63-67 35140727-8 2021 Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity. Nitrates 64-71 nitrate reductase 1 Arabidopsis thaliana 31-48 35140727-8 2021 Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity. Nitrates 64-71 nitrate reductase 1 Arabidopsis thaliana 50-52 35140727-4 2021 Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism. Nitrates 181-188 NIN like protein 7 Arabidopsis thaliana 24-61 35140727-9 2021 We attributed the enhanced salt tolerance of nlp7 to the balanced accumulation of nitrate anions and sodium cations. Nitrates 82-89 NIN like protein 7 Arabidopsis thaliana 45-49 35140727-4 2021 Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism. Nitrates 181-188 NIN like protein 7 Arabidopsis thaliana 63-67 35163124-1 2022 The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite. Nitrates 113-120 nitrate reductase 1 Arabidopsis thaliana 26-30 35163124-1 2022 The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite. Nitrates 113-120 nitrate reductase 2 Arabidopsis thaliana 35-39 35045112-11 2022 Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition. Nitrates 83-90 glucan endo-1,3-beta-glucosidase, basic isoform Malus domestica 8-13 35045112-11 2022 Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition. Nitrates 83-90 glucan endo-1,3-beta-glucosidase, basic isoform Malus domestica 18-23 35052670-4 2022 The organic nitrates studied showed different vasodilation and tolerance profiles, probably due to the ability or inability of the compounds to interact with the aldehyde dehydrogenase-2 enzyme (ALDH-2) involved in bioactivation. Nitrates 12-20 aldehyde dehydrogenase 2 family member Homo sapiens 162-186 35046428-10 2022 These findings offer new perspectives on the mechanisms by which the chrysanthemum CBL interacting protein kinase CmCIPK23 influences nitrate signaling. Nitrates 134-141 cystathionine beta-lyase Arabidopsis thaliana 83-86 35052670-4 2022 The organic nitrates studied showed different vasodilation and tolerance profiles, probably due to the ability or inability of the compounds to interact with the aldehyde dehydrogenase-2 enzyme (ALDH-2) involved in bioactivation. Nitrates 12-20 aldehyde dehydrogenase 2 family member Homo sapiens 195-201 35052670-6 2022 The results of this study could be further evidence of the involvement of ALDH-2 in the development of nitrate tolerance. Nitrates 103-110 aldehyde dehydrogenase 2 family member Homo sapiens 74-80 35052670-7 2022 Moreover, the behavior of organic nitrates with antioxidant properties supports the hypothesis of the involvement of ROS in inactivating ALDH-2. Nitrates 34-42 aldehyde dehydrogenase 2 family member Homo sapiens 137-143 35095967-16 2021 Overall, these results demonstrated that increasing the NH4 +/NO3 - ratio at the seedling stage induced the accumulation of reactive oxygen species, which in turn enhanced root glutathione metabolism and lignification, thereby resulting in increased root oxidative tolerance at the cost of reducing nitrate transport and utilization, which reduced leaf photosynthetic capacity and, ultimately, plant biomass accumulation. Nitrates 299-306 NBL1, DAN family BMP antagonist Homo sapiens 62-65 35047570-6 2021 Correlation analysis showed MEG3 expression highly correlated with ET1 and Nitrate concentration. Nitrates 75-82 maternally expressed 3 Homo sapiens 28-32 35095982-4 2021 Ion-selective electrodes (ISEs) support the possibility of NO 3 - -N measurement by measuring the nitrate ( NO 3 - ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 - ions. Nitrates 99-106 NBL1, DAN family BMP antagonist Homo sapiens 59-63 35095982-4 2021 Ion-selective electrodes (ISEs) support the possibility of NO 3 - -N measurement by measuring the nitrate ( NO 3 - ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 - ions. Nitrates 99-106 NBL1, DAN family BMP antagonist Homo sapiens 109-113 35095982-4 2021 Ion-selective electrodes (ISEs) support the possibility of NO 3 - -N measurement by measuring the nitrate ( NO 3 - ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 - ions. Nitrates 99-106 NBL1, DAN family BMP antagonist Homo sapiens 204-208 35046980-5 2021 The SSP, CEP1 (C-TERMINALLY ENCODED PEPTIDE) enhanced nitrate uptake rate per unit root length in Medicago truncatula plants deprived of N in the high-affinity transport range. Nitrates 54-61 Cysteine proteinases superfamily protein Arabidopsis thaliana 9-13 35046980-6 2021 Single structural variants of M. truncatula and Arabidopsis thaliana specific CEP1 peptides, MtCEP1D1:hyp4,11 and AtCEP1:hyp4,11, enhanced uptake not only of nitrate, but also phosphate and sulfate in both model plant species. Nitrates 158-165 Cysteine proteinases superfamily protein Arabidopsis thaliana 78-82 35046980-6 2021 Single structural variants of M. truncatula and Arabidopsis thaliana specific CEP1 peptides, MtCEP1D1:hyp4,11 and AtCEP1:hyp4,11, enhanced uptake not only of nitrate, but also phosphate and sulfate in both model plant species. Nitrates 158-165 Cysteine proteinases superfamily protein Arabidopsis thaliana 114-120 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 0-7 alternative oxidase 1A Arabidopsis thaliana 44-49 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 0-7 plant uncoupling mitochondrial protein 1 Arabidopsis thaliana 50-54 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 120-127 alternative oxidase 1A Arabidopsis thaliana 44-49 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 120-127 plant uncoupling mitochondrial protein 1 Arabidopsis thaliana 50-54 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 140-147 alternative oxidase 1A Arabidopsis thaliana 44-49 34974624-7 2022 Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition. Nitrates 140-147 plant uncoupling mitochondrial protein 1 Arabidopsis thaliana 50-54 2517590-4 1989 In addition, while the expression of c-myc, following partial hepatectomy returned to basal level by 4 h, the induced expression of c-myc persisted for up to 40 h during the lead nitrate-induced liver cell proliferation. Nitrates 179-186 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 37-42 2557415-9 1989 Thus, it is apparently the nitrate moiety of the chemical structure by which nicorandil actively and strongly reduces [Ca++]i in vascular smooth muscle cells. Nitrates 27-34 carbonic anhydrase 1 Rattus norvegicus 119-125 16667152-6 1989 Incorporation of [(35)S]methionine during nitrate treatment revealed that total soluble protein and nitrate reductase protein synthesis were both depressed by the O(2) environment relative to air, but both recovered when leaves were shifted from O(2) to air. Nitrates 42-49 nitrate reductase [NADH] 1 Zea mays 100-117 2099413-0 1990 Inhibition of platelet activation by the nitrate Sin-1: studies with human aequorin-loaded platelets. Nitrates 41-48 MAPK associated protein 1 Homo sapiens 49-54 2517590-4 1989 In addition, while the expression of c-myc, following partial hepatectomy returned to basal level by 4 h, the induced expression of c-myc persisted for up to 40 h during the lead nitrate-induced liver cell proliferation. Nitrates 179-186 MYC proto-oncogene, bHLH transcription factor Rattus norvegicus 132-137 2544557-3 1989 We have previously identified a locus called frdR which pleiotropically affects nitrate repression of fumarate reductase, trimethylamine N-oxide reductase, and alcohol dehydrogenase gene expression and nitrate induction of nitrate reductase expression (L. V. Kalman and R. P. Gunsalus, J. Bacteriol. Nitrates 80-87 Alcohol dehydrogenase Escherichia coli 160-181 16666874-0 1989 Transient Accumulation of Nitrite Reductase mRNA in Maize following the Addition of Nitrate. Nitrates 84-91 ferredoxin--nitrite reductase, chloroplastic Zea mays 26-43 2790879-12 1989 With regard to the very satisfactory experience with the administration of nitrates in this indication their combined administration with vasopressin or its derivatives is considered. Nitrates 75-83 arginine vasopressin Homo sapiens 138-149 16666874-1 1989 Expression of the gene coding for nitrite reductase (NiR) is induced upon the addition of nitrate. Nitrates 90-97 ferredoxin--nitrite reductase, chloroplastic Zea mays 34-51 16666874-1 1989 Expression of the gene coding for nitrite reductase (NiR) is induced upon the addition of nitrate. Nitrates 90-97 ferredoxin--nitrite reductase, chloroplastic Zea mays 53-56 16666874-3 1989 There is a rapid induction of NiR mRNA upon addition of nitrate, increasing first in the roots and then in the leaves. Nitrates 56-63 ferredoxin--nitrite reductase, chloroplastic Zea mays 30-33 16666874-9 1989 The NiR protein level, on the other hand, increases gradually somewhat after the increase in mRNA and remains at high levels at least for 24 hours after the addition of nitrate. Nitrates 169-176 ferredoxin--nitrite reductase, chloroplastic Zea mays 4-7 16666879-5 1989 When nitrate was supplied to N-starved, etiolated corn plants, nitrate reductase, and glyceraldehyde-3-phosphate dehydrogenase mRNA levels in leaves increased in parallel. Nitrates 5-12 nitrate reductase [NADH] 1 Zea mays 63-80 16666879-5 1989 When nitrate was supplied to N-starved, etiolated corn plants, nitrate reductase, and glyceraldehyde-3-phosphate dehydrogenase mRNA levels in leaves increased in parallel. Nitrates 5-12 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase Zea mays 86-126 16666879-6 1989 When green leaves were treated with nitrate, only nitrate reductase mRNA levels were increased. Nitrates 36-43 nitrate reductase [NADH] 1 Zea mays 50-67 16666879-7 1989 Nitrate is a specific inducer of nitrate reductase in green leaves, but appears to have a more general effect in etiolated leaves. Nitrates 0-7 nitrate reductase [NADH] 1 Zea mays 33-50 16666879-8 1989 In the dark, nitrate induced nitrate reductase expression in both etiolated and green leaves, indicating light and functional chloroplast were not required for enzyme expression. Nitrates 13-20 nitrate reductase [NADH] 1 Zea mays 29-46 16666905-0 1989 Nitrate effects on nitrate reductase activity and nitrite reductase mRNA levels in maize suspension cultures. Nitrates 0-7 nitrate reductase [NADH] 1 Zea mays 19-36 16666905-3 1989 Both NR and NiR mRNA were transiently induced with levels decreasing after the 2 hours despite the continued presence of nitrate in the medium. Nitrates 121-128 nitrate reductase [NADH] 1 Zea mays 5-7 16666905-0 1989 Nitrate effects on nitrate reductase activity and nitrite reductase mRNA levels in maize suspension cultures. Nitrates 0-7 ferredoxin--nitrite reductase, chloroplastic Zea mays 50-67 16666905-3 1989 Both NR and NiR mRNA were transiently induced with levels decreasing after the 2 hours despite the continued presence of nitrate in the medium. Nitrates 121-128 ferredoxin--nitrite reductase, chloroplastic Zea mays 12-15 2501096-5 1989 More recently, a potential molecular explanation for nitrate tolerance has been proposed: sulfhydryl group depletion in smooth muscle cells resulting in reduced formation of S-nitrosothiols on nitrate exposure with resultant reduced activation of cyclic GMP. Nitrates 53-60 5'-nucleotidase, cytosolic II Homo sapiens 254-257 2577296-2 1989 The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma. Nitrates 47-55 alpha hemoglobin stabilizing protein Homo sapiens 93-130 2577296-2 1989 The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma. Nitrates 47-55 alpha hemoglobin stabilizing protein Homo sapiens 132-136 2577296-2 1989 The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma. Nitrates 47-55 5'-nucleotidase, cytosolic II Homo sapiens 199-202 2784476-1 1989 L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and microbes. Nitrates 53-60 NBL1, DAN family BMP antagonist Mus musculus 62-65 2658373-1 1989 Metabolism of organic nitrates results in the formation of inorganic nitrites that can oxidize hemoglobin to methemoglobin. Nitrates 22-30 hemoglobin subunit gamma 2 Homo sapiens 109-122 2658373-3 1989 Based on the results of these trials, organic nitrate use does appear to increase methemoglobin content but not to a clinically significant extent. Nitrates 46-53 hemoglobin subunit gamma 2 Homo sapiens 82-95 2722365-1 1989 Increasing levels of nitrate (NO3-) in drinking water in Denmark is of concern due to the possibility of an associated increase in long-term exposure to endogeneously formed N-nitroso compounds. Nitrates 21-28 NBL1, DAN family BMP antagonist Homo sapiens 30-33 2722365-3 1989 People drinking nitrate-free water have an intake of 37 mg NO3- per day. Nitrates 16-23 NBL1, DAN family BMP antagonist Homo sapiens 59-62 2548453-3 1989 The study showed that the nitrate content in berseem grown near the factory had higher NO3 values exceeding 2% NO3 in DM in some cases. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 87-90 2548453-3 1989 The study showed that the nitrate content in berseem grown near the factory had higher NO3 values exceeding 2% NO3 in DM in some cases. Nitrates 26-33 NBL1, DAN family BMP antagonist Homo sapiens 111-114 16347879-3 1989 Nitrate affinity (K(m)) for mixed populations of denitrifying bacteria in unfertilized agricultural soils and pond sediments ranged from 1.8 to 13.7 muM. Nitrates 0-7 latexin Homo sapiens 149-152 2573982-4 1989 CONCLUSION: A desensitization of soluble guanylate cyclase to activation with NO can be demonstrated under non-physiological conditions (disrupted cells) in homogenates from nitrate tolerant RA. Nitrates 174-181 guanylate cyclase Bos taurus 41-58 2733245-3 1989 Plasma SOD activities were measured by the nitrate method. Nitrates 43-50 superoxide dismutase 1 Homo sapiens 7-10 2468964-2 1989 The present study was performed to elucidate if large oral doses of N-acetylcysteine (NAC, 2,400 mg X 2), a donor of sulfhydryl groups, given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG). Nitrates 194-201 NACC family member 2 Homo sapiens 68-103 2468964-2 1989 The present study was performed to elucidate if large oral doses of N-acetylcysteine (NAC, 2,400 mg X 2), a donor of sulfhydryl groups, given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG). Nitrates 220-227 NACC family member 2 Homo sapiens 68-103 2568418-4 1989 Some auranofin analogues having chloride or nitrate leaving groups that inhibit DNA polymerase-alpha were found to be potent inhibitors of IL-1 induced resorption. Nitrates 44-51 DNA polymerase alpha 1, catalytic subunit Homo sapiens 80-100 2559883-3 1989 Nitrosylhemoglobin shows a characteristic electron spin resonance (ESR) signal due to an odd electron localized on the nitrogen atom of NO and reacts with oxygen to yield nitrate and methemoglobin, which is rapidly reduced by methemoglobin reductase in red cells. Nitrates 171-178 hemoglobin subunit gamma 2 Homo sapiens 226-239 2511690-7 1989 The real clinical importance of nitrates became, however, evident only in the last decade with the discovery of EDRF, the so-called endothelial-derived relaxing factor, an endogenous compound of endothelial origin at least partly consisting of nitrous oxide and therefore, like nitrates, it exerts its effect through the stimulation of cGMP. Nitrates 32-40 alpha hemoglobin stabilizing protein Homo sapiens 112-116 2511690-7 1989 The real clinical importance of nitrates became, however, evident only in the last decade with the discovery of EDRF, the so-called endothelial-derived relaxing factor, an endogenous compound of endothelial origin at least partly consisting of nitrous oxide and therefore, like nitrates, it exerts its effect through the stimulation of cGMP. Nitrates 278-286 alpha hemoglobin stabilizing protein Homo sapiens 112-116 16666376-5 1988 Nitrate stimulated a rapid induction of the NiR mRNA in both roots and leaves. Nitrates 0-7 ferredoxin--nitrite reductase, chloroplastic Zea mays 44-47 2555979-3 1989 Nitrate (GTN)-induced relaxation was accompanied by a 2- to 3-fold increase of cyclic GMP content in the vessel walls. Nitrates 0-7 5'-nucleotidase, cytosolic II Homo sapiens 86-89 2573982-2 1989 Nitrate tolerance significantly attenuated NTG-induced vasodilation of precontracted (1.0 microM norepinephrine) RA, increase in cyclic GMP in RA and SMC, and activation of guanylate cyclase in homogenates as compared to controls. Nitrates 0-7 guanylate cyclase Bos taurus 173-190 16666423-0 1988 The role of nitrate and ammonium ions and light on the induction of nitrate reductase in maize leaves. Nitrates 12-19 nitrate reductase [NADH] 1 Zea mays 68-85 16666409-8 1988 Only the plastidic portion of the glutamine synthetase increased to about 80% in cells grown on ammonium (compared to about 40% in cells grown on nitrate). Nitrates 146-153 uncharacterized protein Chlamydomonas reinhardtii 34-54 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrates 126-133 interferon gamma Mus musculus 12-28 3170537-4 1988 Mutant 2172 is affected in methylammonium but not in ammonium uptake capacity and shows derepressed nitrate and nitrite reductase activities in media containing nitrate plus methylammonium but not in nitrate plus ammonium media. Nitrates 161-168 uncharacterized protein Chlamydomonas reinhardtii 112-129 3170537-4 1988 Mutant 2172 is affected in methylammonium but not in ammonium uptake capacity and shows derepressed nitrate and nitrite reductase activities in media containing nitrate plus methylammonium but not in nitrate plus ammonium media. Nitrates 161-168 uncharacterized protein Chlamydomonas reinhardtii 112-129 3170537-7 1988 From genetic and kinetic evidences we conclude that in C. reinhardtii two different carriers are responsible for the transport of both ammonium and methylammonium and that methylammonium (ammonium) transport is a reversible process probably inhibited by the intracellular ammonium which, in turn, regulates nitrate and nitrite reductase levels. Nitrates 307-314 uncharacterized protein Chlamydomonas reinhardtii 319-336 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrates 126-133 interferon gamma Rattus norvegicus 30-40 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrates 126-133 tumor necrosis factor Mus musculus 58-79 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrates 126-133 tumor necrosis factor Rattus norvegicus 81-85 3142779-2 1988 Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages. Nitrates 126-133 NBL1, DAN family BMP antagonist Mus musculus 135-138 3154691-12 1988 Therefore nitrates may particularly be effective in vessels with deficient EDRF release. Nitrates 10-18 alpha hemoglobin stabilizing protein Homo sapiens 75-79 2851879-5 1988 The marked enrichment of H+, SO4(2-) and NO3- in precipitation compared with NH4+ could be explained by assuming either that SO2 and NO2 are oxidized in cloud droplets or that acidic sulfate and nitrate are scavenged directly in-cloud or below-cloud. Nitrates 195-202 NBL1, DAN family BMP antagonist Homo sapiens 41-44 16347651-0 1988 Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 87-92 16347651-0 1988 Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O. Nitrates 22-29 NBL1, DAN family BMP antagonist Homo sapiens 96-101 16347658-2 1988 The isolate, designated GS-15, grew in defined anaerobic medium with acetate as the sole electron donor and Fe(III), Mn(IV), or nitrate as the sole electron acceptor. Nitrates 128-135 Bet1 golgi vesicular membrane trafficking protein like Homo sapiens 24-29 16666313-1 1988 The influence of light-dark cycles and nitrate supply on nitrate reductase (NR) mRNA levels was studied in two plant species, tobacco (Nicotiana tabacum) and tomato (Lycopersicon esculentum) using specific NR DNA probes. Nitrates 39-46 nitrate reductase [NADH] Solanum lycopersicum 57-74 16666313-1 1988 The influence of light-dark cycles and nitrate supply on nitrate reductase (NR) mRNA levels was studied in two plant species, tobacco (Nicotiana tabacum) and tomato (Lycopersicon esculentum) using specific NR DNA probes. Nitrates 39-46 nitrate reductase [NADH] Solanum lycopersicum 76-78 3393528-0 1988 Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains. Nitrates 13-20 nitrate reductase 1 Arabidopsis thaliana 74-91 3422089-2 1988 These metabolic changes occur in parallel with L-citrulline, nitrate, and nitrate synthesis from L-arginine by EMT-6 cells. Nitrates 74-81 IL2 inducible T cell kinase Mus musculus 111-114 24221417-9 1988 Nitrate reductase was induced in bacteroids of strain CB1809 when they were incubated in-vitro with nitrate or nitrite. Nitrates 100-107 inducible nitrate reductase [NADH] 1 Glycine max 0-17 3137069-3 1988 Evidence for nitrate induced PGI2 stimulation is presented by inhibition of its formation by indomethacin and dexamethasone, the demonstration of inhibition of thrombin induced thromboxane generation of washed platelet suspensions by nitrate stimulated vessel incubates and an enhanced accumulation of the hydrolysis product of PGI2, 6-oxo-PGF1 alpha, in incubates of teopranitol stimulated vessels. Nitrates 234-241 coagulation factor II, thrombin Bos taurus 160-168 2887427-15 1987 The ATPase is insensitive to azide or vanadate but is inhibited by relatively low concentrations of nitrate. Nitrates 100-107 ATZ20_RS04105 Sulfolobus acidocaldarius 4-10 3137069-3 1988 Evidence for nitrate induced PGI2 stimulation is presented by inhibition of its formation by indomethacin and dexamethasone, the demonstration of inhibition of thrombin induced thromboxane generation of washed platelet suspensions by nitrate stimulated vessel incubates and an enhanced accumulation of the hydrolysis product of PGI2, 6-oxo-PGF1 alpha, in incubates of teopranitol stimulated vessels. Nitrates 13-20 coagulation factor II, thrombin Bos taurus 160-168 3110273-0 1987 Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. Nitrates 21-28 interferon gamma Mus musculus 95-111 3110273-5 1987 Recombinant IFN-gamma also stimulated nitrite/nitrate synthesis by C3H/He and CeH/HeJ macrophages as did LPS (C3H/He only) and hk BCG. Nitrates 46-53 interferon gamma Mus musculus 12-21 3110273-6 1987 When given concurrently with either LPS or hk BCG, IFN-gamma enhanced C3H/He and C3H/HeJ macrophage nitrite/nitrate synthesis over that produced by macrophages treated with either LPS or hk BCG alone. Nitrates 108-115 interferon gamma Mus musculus 51-60 3110273-10 1987 Taken together, these results indicate that T cell lymphokines and IFN-gamma are powerful modulators of macrophage nitrite/nitrate synthesis during BCG infection and in vitro, and nitrite/nitrate synthesis appears to be common property of both primed and fully activated macrophage populations. Nitrates 123-130 interferon gamma Mus musculus 67-76 3553637-0 1987 Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water. Nitrates 61-69 septin 8 Homo sapiens 17-23 2439225-2 1987 Murine peritoneal macrophages, elicited in vivo with thioglycolate and stimulated in vitro with LPS and/or gamma-interferon (IFN), produce copious amounts of nitrate and nitrite. Nitrates 158-165 interferon gamma Mus musculus 107-129 16665499-4 1987 Addition of nitrate to inactive nitrate reductase of mutant 305 caused the in vivo reactivation of the enzyme and halted its degradation. Nitrates 12-19 uncharacterized protein Chlamydomonas reinhardtii 32-49 2952501-7 1987 The ATPase activity is not inhibited by N,N"-dicyclohexylcarbodiimide, azide or vanadate, but it is by the vascular ATPase inhibitor nitrate with an [I]50 of 8 mM. Nitrates 133-140 ATZ20_RS04105 Sulfolobus acidocaldarius 4-10 3314296-1 1987 (A) The effects of phosphate, chloride, nitrate, pyruvate, malate, succinate and glutamate ions on the kinetics of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) were studied with MgATP2- and 3-P-glycerate as variable substrates. Nitrates 40-47 phosphoglycerate kinase Saccharomyces cerevisiae S288C 121-144 3314296-1 1987 (A) The effects of phosphate, chloride, nitrate, pyruvate, malate, succinate and glutamate ions on the kinetics of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) were studied with MgATP2- and 3-P-glycerate as variable substrates. Nitrates 40-47 F1F0 ATP synthase subunit gamma Saccharomyces cerevisiae S288C 146-152 2952501-7 1987 The ATPase activity is not inhibited by N,N"-dicyclohexylcarbodiimide, azide or vanadate, but it is by the vascular ATPase inhibitor nitrate with an [I]50 of 8 mM. Nitrates 133-140 ATZ20_RS04105 Sulfolobus acidocaldarius 116-122 16664862-10 1986 The results provide additional support to our claim that wild-type soybean contains three NR isozymes, namely, constitutive NADPH:NR (c(1)NR), constitutive NADH:NR (c(2)NR), and nitrate-inducible NR (iNR). Nitrates 178-185 inducible nitrate reductase [NADH] 1 Glycine max 90-92 16347270-3 1987 Significant nitrate concentrations (1 to 27 muM) were observed in the sediment of Lake Vechten during the nonstratified period; the concentration profiles showed a successive depletion of oxygen, nitrate, and sulfate with depth. Nitrates 12-19 latexin Homo sapiens 44-47 3015963-2 1986 Besides the reduction of nitrate by NADH, nitrate reductase also catalyzes the partial activities NADH:cytochrome c reductase, NADH:ferricyanide reductase, and reduced methyl viologen:nitrate reductase. Nitrates 25-32 nitrate reductase [NADH] 1 Zea mays 42-59 3015963-2 1986 Besides the reduction of nitrate by NADH, nitrate reductase also catalyzes the partial activities NADH:cytochrome c reductase, NADH:ferricyanide reductase, and reduced methyl viologen:nitrate reductase. Nitrates 25-32 nitrate reductase [NADH] 1 Zea mays 184-201 16664862-5 1986 In vitro FMNH(2)-dependent nitrate reduction and Cyt c reductase activity of nitrate-grown plants, and nitrogenous gas evolution during in vivo NR assays of urea-grown plants, were also decreased in the mutants. Nitrates 77-84 chalcone reductase CHR1 Glycine max 55-64 16665101-1 1986 Bromphenol blue, which was reduced with dithionite, was found to support nitrate reduction catalyzed by squash NADH:nitrate reductase at a rate about 5 times greater than NADH with freshly prepared enzyme and 10 times or more with enzyme having been frozen and thawed. Nitrates 73-80 nitrate reductase [NADH] 1 Zea mays 116-133 16665101-2 1986 Kinetic analysis of bromphenol blue as a substrate for squash nitrate reductase yielded apparent K(m) values of 60 micromolar for bromphenol blue at 10 millimolar nitrate and 500 micromolar for nitrate at 0.2 millimolar bromphenol blue. Nitrates 163-170 nitrate reductase [NADH] 1 Zea mays 62-79 3798854-1 1986 The quantitative determination of nitrate-reducing microorganisms in food is important because of their role in the formation of N-nitroso compounds and methemoglobin. Nitrates 34-41 hemoglobin subunit gamma 2 Homo sapiens 153-166 3085308-10 1986 The effects of nitrates, nitrites and mechanisms of the reconversion of methemoglobin to hemoglobin are discussed. Nitrates 15-23 HGB Sus scrofa 75-85 3955002-4 1986 All of the ligands except for the halides, nitrate, and acetate form exclusively low-spin complexes in analogy to results obtained with the spectroscopically related protein, cytochrome P-450-CAM [Sono, M., & Dawson, J.H. Nitrates 43-50 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 175-191 16664678-4 1986 After 2 days of treatment with 10 millimolar nitrate, acetylene reduction by nodulated roots was inhibited by 48% but there was no effect on either acetylene reduction by isolated bacteroids or in vitro activity of nodule cytoplasmic glutamine synthetase, glutamine oxoglutarate aminotransferase, xanthine dehydrogenase, uricase, or allantoinase. Nitrates 45-52 uricase-2 isozyme 1 Glycine max 321-328 16664640-9 1986 Western blots of polyacrylamide gels of native and denatured crude extracts showed that NADH:NR polypeptide was absent prior to treatment with N nutrients, but appeared after nitrate was given in dark or light. Nitrates 175-182 nitrate reductase [NADH] 1 Zea mays 93-95 16664642-6 1986 Stem NO(3) (-) concentration and in vivo leaf NR activity were significantly correlated (R(2) = 0.69 with nitrate in the assay medium and 0.74 without nitrate in the medium at P = 0.001) across six combinations of reproductive and soil N-treatment. Nitrates 106-113 inducible nitrate reductase [NADH] 1 Glycine max 46-48 16664642-6 1986 Stem NO(3) (-) concentration and in vivo leaf NR activity were significantly correlated (R(2) = 0.69 with nitrate in the assay medium and 0.74 without nitrate in the medium at P = 0.001) across six combinations of reproductive and soil N-treatment. Nitrates 151-158 inducible nitrate reductase [NADH] 1 Glycine max 46-48 3754852-0 1986 The binding of plutonium to transferrin in the presence of tri-n-butyl phosphate or nitrate and its release by diethylenetriaminepenta-acetate and the tetrameric catechoylamide ligand LICAMC(C). Nitrates 84-91 transferrin Homo sapiens 28-39 11538660-5 1986 The nuclear NTPase activity was not inhibited by vanadate, oligomycin, or nitrate, but was inhibited by relatively low concentrations of quercetin and the calmodulin inhibitor, compound 48/80. Nitrates 74-81 inosine triphosphatase Homo sapiens 12-18 4079911-3 1985 For the organic nitrates, increases in the rate of reaction with cysteine, in general, ran parallel both with increases in pharmacological potency (flow in the Langendorff heart) and with increases in total clearance. Nitrates 16-24 RAN, member RAS oncogene family Homo sapiens 87-90