PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24241316-3	1985	By using darkened or illuminated leaves in the absence or presence of nitrate, it has been confirmed that nitrate is required in the in-vivo synthesis of NiR and that this synthesis is stimulated by light.	Nitrates	106-113	ferredoxin--nitrite reductase, chloroplastic	Triticum aestivum	154-157
24241316-8	1985	Nitrate appears to regulate NiR synthesis by triggering transcription whereas the light may control the level of transcription or translation.	Nitrates	0-7	ferredoxin--nitrite reductase, chloroplastic	Triticum aestivum	28-31
3926614-7	1985	The effect of the nitrates on the venous capacitance system is reflected by the increase in the PEP/LVET ratio where NTGO and NTGB elicited marked actions and those of sustained-release ISDN and IS 5-MN were of a lesser extent.	Nitrates	18-26	progestagen associated endometrial protein	Homo sapiens	96-99
6427300-0	1984	Methemoglobin levels produced by organic nitrates in patients with coronary artery disease.	Nitrates	41-49	hemoglobin subunit gamma 2	Homo sapiens	0-13
16664208-6	1985	Nitrate supply was therefore implicated as limiting to leaf NR activity during the decline associated with flowering and early seed development.	Nitrates	0-7	inducible nitrate reductase [NADH] 1	Glycine max	60-62
16664208-8	1985	As no significant increase in leaf NR activity was observed in response to light enhancement alone, leaf nitrate supply was further implicated as more limiting to leaf NR activity than was photosynthate supply during flowering and early seed development.	Nitrates	105-112	inducible nitrate reductase [NADH] 1	Glycine max	168-170
16664214-5	1985	Nitrate-grown nr(1) mutant soybean plants yielded a NADH:nitrate reductase (designated iNR) when Blue Sepharose columns were eluted with NADH; NADPH failed to elute any NR form from Blue Sepharose loaded with this extract.	Nitrates	0-7	chalcone reductase CHR1	Glycine max	65-74
16664214-10	1985	The iNR preferred NADH over NADPH and had an apparent Michaelis constant of 0.13 millimolar for nitrate.Thus, wild-type soybean contains two forms of constitutive nitrate reductase, both differing in their physical properties from nitrate reductases common in higher plants.	Nitrates	96-103	chalcone reductase CHR1	Glycine max	171-180
4089329-0	1985	[Environmental nitrates and the experimental formation of methemoglobin].	Nitrates	15-23	hemoglobin subunit gamma 2	Homo sapiens	58-71
18963604-2	1984	The differential pulse polarographic peak-height is proportional to nitrate concentration from 1 to 50 muM.	Nitrates	68-75	latexin	Homo sapiens	103-106
4022112-0	1985	Determination of nitrates in milk by ion-chromatography.	Nitrates	17-25	Weaning weight-maternal milk	Bos taurus	29-33
4022112-1	1985	A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm).	Nitrates	47-55	Weaning weight-maternal milk	Bos taurus	63-67
4022112-1	1985	A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm).	Nitrates	47-55	Weaning weight-maternal milk	Bos taurus	75-79
4022112-1	1985	A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm).	Nitrates	47-55	Weaning weight-maternal milk	Bos taurus	75-79
4022112-1	1985	A method is described for the determination of nitrates in cow milk, human milk, milk powder or milk-based infant formulae using liquid chromatography on Spheron DEAE and a direct photometric detection (205 nm).	Nitrates	47-55	Weaning weight-maternal milk	Bos taurus	75-79
6427300-1	1984	To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy.	Nitrates	34-42	hemoglobin subunit gamma 2	Homo sapiens	77-90
6427300-1	1984	To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy.	Nitrates	34-42	hemoglobin subunit gamma 2	Homo sapiens	92-105
6427300-1	1984	To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy.	Nitrates	34-41	hemoglobin subunit gamma 2	Homo sapiens	77-90
6427300-1	1984	To determine if ordinary doses of nitrates produce a significant increase in methemoglobin, methemoglobin levels were measured in 59 randomly selected patients with coronary artery disease and unstable angina pectoris who were receiving organic nitrate therapy.	Nitrates	34-41	hemoglobin subunit gamma 2	Homo sapiens	92-105
6427300-7	1984	It is concluded that commonly used dosages of nitrates are capable of causing elevations of methemoglobin which are probably not of routine clinical significance.	Nitrates	46-54	hemoglobin subunit gamma 2	Homo sapiens	92-105
16662876-5	1983	Inasmuch as nitrate reduction results in the production of OH(-) and stimulates the synthesis of organic anions, it was postulated that nitrate reductase activity of roots is stimulated by the released OH(-) or by the synthesized organic anions rather than by nitrate itself.	Nitrates	12-19	nitrate reductase [NADH] 1	Zea mays	136-153
16663186-5	1983	Nitrate assimilation (nitrate reductase activity and total accumulation of reduced-N) was also enhanced in response to vegetative apex removal.	Nitrates	0-7	inducible nitrate reductase [NADH] 1	Glycine max	22-39
6613236-8	1983	SIN 1 effectively dilates nonstenotic and especially stenotic epicardial coronary arteries, as it is already known for nitrates and calcium-channel blockers.	Nitrates	119-127	MAPK associated protein 1	Homo sapiens	0-5
6372319-0	1983	Nitrate reduction in so-called nitrate reductase (NR) negative strains of the genus Mycobacterium.	Nitrates	0-7	GR01_RS13310	Mycobacterium chelonae	31-48
6372319-0	1983	Nitrate reduction in so-called nitrate reductase (NR) negative strains of the genus Mycobacterium.	Nitrates	0-7	GR01_RS13310	Mycobacterium chelonae	50-52
6749995-2	1982	The method involves a sandwich technique in which antiserum to human IgE is adsorbed on a cellulose acetate/nitrate disc which is attached to a plastic StiQTM sampler.	Nitrates	108-115	immunoglobulin heavy constant epsilon	Homo sapiens	69-72
6874197-7	1983	Clearly elevated nitrate contents were revealed by the resuls of measurements: 13% of samples showed values above the maximal concentration admissible under the EC Drinking Water Directive of 50 mg NO-3/l and 42% above the EC guide level.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	198-202
16346140-1	1982	Bacteria able to perform dissimilatory nitrate reduction to ammonium were isolated from low-oxygen masses in the Baltic Sea.	Nitrates	39-46	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	120-123
16662475-0	1982	Differential effect of tungsten on the development of endogenous and nitrate-induced nitrate reductase activities in soybean leaves.	Nitrates	69-76	inducible nitrate reductase [NADH] 1	Glycine max	85-102
16662475-1	1982	The effect of tungsten on the development of endogenous and nitrate-induced NADH- and FMNH(2)-linked nitrate reductase activities in primary leaves of 10-day-old soybean (Glycine max [L.] Merr.)	Nitrates	60-67	chalcone reductase CHR1	Glycine max	109-118
16662475-4	1982	High levels of endogenous nitrate reductase activities developed in leaves of seedlings grown without nitrate.	Nitrates	26-33	chalcone reductase CHR1	Glycine max	34-43
16662475-8	1982	By contrast, in nitrate-grown seedlings, tungsten only inhibited the nitrate-induced portion of NADH-linked nitrate reductase activity, whereas the FMNH(2)-linked activity was inhibited completely.	Nitrates	69-76	chalcone reductase CHR1	Glycine max	116-125
16662475-10	1982	The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system.	Nitrates	42-49	chalcone reductase CHR1	Glycine max	50-59
16662475-10	1982	The complete inhibition of FMNH(2)-linked nitrate reductase activity by tungsten in nitrate-grown plants was apparently an artifact caused by the reduction of nitrite by nitrite reductase in the assay system.	Nitrates	42-49	chalcone reductase CHR1	Glycine max	178-187
16662475-11	1982	The results suggest that in soybean leaves either the endogenous nitrate reductase does not require molybdenum or the molybdenum present in the seed is preferentially utilized by the enzyme complex as compared to nitrate-induced nitrate reductase.	Nitrates	65-72	chalcone reductase CHR1	Glycine max	73-82
6141677-6	1983	In the presence of the vital stain methylene blue - which was shown in vitro to prevent nitrate-induced activation of guanylate cyclase, the enzyme which forms cGMP from GTP - the relaxant actions as well as the increases in cGMP produced by several of these nitro-compounds in coronary strips were almost abolished.	Nitrates	88-95	guanylate cyclase	Bos taurus	118-135
17791587-1	1982	Fog water collected at three sites in Los Angeles and Bakersfield, California, was found to have higher acidity and higher concentrations of sulfate, nitrate, and ammonium than previously observed in atmospheric water droplets.	Nitrates	150-157	zinc finger protein, FOG family member 1	Homo sapiens	0-3
16662417-4	1982	Correlations between nitrate or nitrite concentration in nodules and nodule weight/plant were highly significant.Cytosol from soybean nodules was found to contain NADH-dependent nitrate reductase activity (typical activity was 0.1 micromole per milligram protein x hour).	Nitrates	21-28	chalcone reductase CHR1	Glycine max	186-195
16662417-6	1982	Growth of nodules formed by the mutant lacking nitrate reductase was inhibited by nitrate.	Nitrates	47-54	chalcone reductase CHR1	Glycine max	55-64
16345884-6	1981	Anaerobic treatment of RDX wastewaters, which also contain high nitrate levels, would permit the denitrification to occur, with concurrent degradation of RDX ultimately to a mixture of hydrazines and methanol.	Nitrates	64-71	radixin	Homo sapiens	23-26
7135816-7	1982	The amount of blood methemoglobin was found to correlate directly with the percent of nitrates in the ration.	Nitrates	86-94	hemoglobin subunit gamma 2	Homo sapiens	20-33
7306876-9	1981	This agrees well with the nitrate partitioning observed by the acetylene inhibition method in which 30--40% of the NO3- -N was recovered as N2O.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
16662109-3	1981	Biosynthetic glutamine synthetase activity was 1.5 to 1.8 times greater in nitrogen-limited cells than cells grown at high levels of the three nitrogen sources.Conversely, glutamate dehydrogenase (both NADH- and NADPH-dependent activities) was greatest in cells grown at high levels of asparagine or ammonium, while nitrate-grown cells possessed little activity at all concentrations employed.	Nitrates	316-323	glutamate-ammonia ligase	Homo sapiens	13-33
24276702-0	1981	Glutamine synthetase of Chlamydomonas: its role in the control of nitrate assimilation.	Nitrates	66-73	glutamate-ammonia ligase	Homo sapiens	0-20
6459097-0	1981	The dose of nicorandil in men predicted from the inhibition of MAO activity by organic nitrates.	Nitrates	87-95	monoamine oxidase A	Rattus norvegicus	63-66
16661906-3	1981	The nitrate-free in vivo assay system of nitrate reductase was used for measuring the production of nitrite.	Nitrates	4-11	chalcone reductase CHR1	Glycine max	49-58
6973419-6	1981	Coronary artery bypass grafting in a subgroup of patients did not affect the mean plasma PF4 concentration during 1 year of follow-up after bypass surgery, but medical therapy for angina with increasing doses of propranolol and nitrates significantly reduced PF4 concentration in another subgroup of patients who were not considered to be candidates for surgical therapy.	Nitrates	228-236	platelet factor 4	Homo sapiens	259-262
7209517-1	1981	Radioactive nitrogen-13 from nitrite (NO2-) or nitrate (NO3-) administered intratracheally or intravenously without added carrier to mice or rabbits was distributed evenly throughout most organs and tissues regardless of the entry route or the anion administered.	Nitrates	47-54	NBL1, DAN family BMP antagonist	Mus musculus	56-59
7269804-3	1981	When the alimentary nitrate intake is in the range of 50 mg NO3- the nitrate values in saliva of adults and children follow a Gaussian normal distribution.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
6975421-7	1981	BV1 differs from B. gazogenes in cell size, pattern of pigment production, nutritional characteristics, the ability to perform anaerobic respiration using nitrate as a terminal electron acceptor, sensitivity to a newly discovered lytic phage and to the antibiotic vibriostat O/129.	Nitrates	155-162	endogenous ecotropic MuLV 2	Mus musculus	0-3
7269804-3	1981	When the alimentary nitrate intake is in the range of 50 mg NO3- the nitrate values in saliva of adults and children follow a Gaussian normal distribution.	Nitrates	69-76	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
16345620-1	1980	During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism.	Nitrates	73-80	MS	Homo sapiens	52-56
16661600-4	1980	Increases in nitrate supply resulted in decreases in nitrate reductase activity and negligible increases in reduced N in the roots of both hybrids.	Nitrates	13-20	nitrate reductase [NADH] 1	Zea mays	53-70
16661600-6	1980	Hybrid B also had lower nitrate reductase activity at all levels of external nitrate and accumulated less reduced N than did hybrid C, except when the plants were grown at 2.5 millimolar nitrate.	Nitrates	77-84	nitrate reductase [NADH] 1	Zea mays	24-41
16661493-4	1980	Cells which survived the chlorate treatment then were transferred to casein hydrolysate medium and have been cultured in the absence of chlorate for more than 18 months (NR1).DI-6 cells can grow in a nitrate-based medium, whereas NR1 cells can take up nitrate but cannot use it as a N source.	Nitrates	200-207	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	170-173
16661493-4	1980	Cells which survived the chlorate treatment then were transferred to casein hydrolysate medium and have been cultured in the absence of chlorate for more than 18 months (NR1).DI-6 cells can grow in a nitrate-based medium, whereas NR1 cells can take up nitrate but cannot use it as a N source.	Nitrates	200-207	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	230-233
16661493-5	1980	The inability of NR1 to assimilate nitrate appears to be due to the lack of an active nitrate reductase in these cells.	Nitrates	35-42	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	17-20
16661493-6	1980	Through the use of a variety of electron donors and acceptors, the lack of nitrate reductase activity in NR1 cells was shown to be due to the absence of, or a defect in, that component of the enzyme which mediates the reduction of nitrate to nitrite.In other experiments, DI-6 and NR1 were grown on a solid medium containing casein hydrolysate (2 grams liter(-1)) as the sole N source.	Nitrates	75-82	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	105-108
16661493-6	1980	Through the use of a variety of electron donors and acceptors, the lack of nitrate reductase activity in NR1 cells was shown to be due to the absence of, or a defect in, that component of the enzyme which mediates the reduction of nitrate to nitrite.In other experiments, DI-6 and NR1 were grown on a solid medium containing casein hydrolysate (2 grams liter(-1)) as the sole N source.	Nitrates	75-82	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	281-284
16345620-1	1980	During microaerophilic growth of magnetic spirillum MS-1 on tartrate and nitrate, a maximal cell density was obtained at an initial oxygen partial pressure of 17 Pa. A transient accumulation of nitrous oxide and a 1:2 (mol/mol) stoichiometry between tartrate oxidation and nitrate reduction were observed, indicating that the organism carried out a respiratory type of metabolism.	Nitrates	273-280	MS	Homo sapiens	52-56
6986356-4	1980	Alcohol dehydrogenase production was largely unaffected by catabolite repression but was repressed by nitrate under both aerobic and anaerobic conditions.	Nitrates	102-109	Alcohol dehydrogenase	Escherichia coli	0-21
7374672-6	1980	The rate constant k2 was temperature-dependent with a Q10 of 1.11 between 5 degrees C and 30 degrees C. Aromatic carboxylic acids known to block sarcolemmal Cl conductance (GCl) specifically lowered k2 by 25% at 30 degrees C, as did replacement of external Cl with nitrate.	Nitrates	265-272	germ cell-less 2, spermatogenesis associated	Homo sapiens	173-176
16661245-7	1980	Assays of the NADPH-eluted NR with different concentrations of nitrate revealed that the highest activity was obtained in 80 millimolar KNO(3).	Nitrates	63-70	inducible nitrate reductase [NADH] 1	Glycine max	27-29
16661245-8	1980	Thus, this fraction has properties similar to the low nitrate affinity NAD(P)H:NR of soybean leaves.	Nitrates	54-61	inducible nitrate reductase [NADH] 1	Glycine max	79-81
16661245-10	1980	Assays of this fraction with different nitrate concentrations revealed that this NR had a higher nitrate affinity and was similar to the NADH:NR of soybean leaves.	Nitrates	39-46	inducible nitrate reductase [NADH] 1	Glycine max	81-83
16661245-10	1980	Assays of this fraction with different nitrate concentrations revealed that this NR had a higher nitrate affinity and was similar to the NADH:NR of soybean leaves.	Nitrates	97-104	inducible nitrate reductase [NADH] 1	Glycine max	81-83
16661380-9	1980	From the patterns of plant nitrate content it was deduced that the low nitrate reductase genotypes terminated nitrate absorption sooner than the high nitrate reductase types.	Nitrates	27-34	nitrate reductase [NADH] 1	Zea mays	71-88
16660571-6	1978	Because the specific activity of nitrate reductase was severalfold lower than the other enzymes involved in nitrate assimilation, nitrate reduction is indicated as the rate-limiting step in situ.	Nitrates	108-115	nitrate reductase [NADH] 1	Zea mays	33-50
11898-1	1976	Each mole of oxyhemoglobin iron converted to methemoglobin causes the oxidation of 1.5 mol of nitrite to nitrate and consumes 1 mol of protons.	Nitrates	105-112	hemoglobin subunit gamma 2	Homo sapiens	45-58
16660485-15	1978	The inhibition of nitrate reductase was noncompetitive with nitrate but caused a decrease in V(max).The isolated inhibitor was inactivated in the light, but after 24 hours in the dark full inhibitory activity returned.	Nitrates	18-25	chalcone reductase CHR1	Glycine max	26-35
868388-1	1977	Ultraviolet light (PRK-2) induces the formation of various amino acids (lysine, asparaginic, as well as traces of some other acids) in mannose, glucose and arabinose solutions containing various nitrates.	Nitrates	195-203	protein kinase N2	Homo sapiens	19-24
629538-0	1978	Induction of a dissimilatory reduction pathway of nitrate in Halobacterium of the Dead Sea.	Nitrates	50-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	87-90
15657-1	1977	A highly purified preparation of glutamine synthetase from chlorella grown on a medium containing nitrate as a sole source of nitrogen, was isolated and characterized by disc-electrophoresis and analytical ultracentrifugation.	Nitrates	98-105	glutamate-ammonia ligase	Homo sapiens	33-53
184842-6	1976	The proportion of the cytochrome c which is reduced during the second stage is oxidizable by either nitrate or H2O2 and is reduced again when the nitrate or H2O2 have been depleted.	Nitrates	100-107	cytochrome c, somatic	Homo sapiens	22-34
16659754-2	1976	Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase.	Nitrates	18-25	nitrate reductase [NADH] 1	Zea mays	80-97
16659754-2	1976	Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase.	Nitrates	18-25	nitrate reductase [NADH] 1	Zea mays	211-228
16659754-2	1976	Decreases in leaf nitrate supply were associated with decreases in induction of nitrate reductase, thus supporting the view that the influx of nitrate to a tissue is a major factor in regulation of the level of nitrate reductase.	Nitrates	80-87	nitrate reductase [NADH] 1	Zea mays	211-228
16659756-4	1976	were designed to determine the relative limitations of NO(3) (-), NADH, and nitrate reductase (NR) per se on nitrate metabolism as affected by light and temperature.	Nitrates	76-83	inducible nitrate reductase [NADH] 1	Glycine max	95-97
16659704-2	1976	The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant.	Nitrates	20-27	nitrate reductase [NADH] 1	Zea mays	86-103
16659704-2	1976	The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant.	Nitrates	40-47	nitrate reductase [NADH] 1	Zea mays	86-103
16659704-2	1976	The roles that leaf nitrate content and nitrate flux play in regulating the levels of nitrate reductase activity (NRA) were investigated in 8- to 14-day old maize (Zea mays L.) plants containing high nitrate levels while other environmental and endogenous factors were constant.	Nitrates	40-47	nitrate reductase [NADH] 1	Zea mays	86-103
184842-6	1976	The proportion of the cytochrome c which is reduced during the second stage is oxidizable by either nitrate or H2O2 and is reduced again when the nitrate or H2O2 have been depleted.	Nitrates	146-153	cytochrome c, somatic	Homo sapiens	22-34
983544-1	1976	Daily intake of nitrate and nitrate by German Federal Republic resident was calculated to 75 mg NO3- and 3.3 mg NO2-.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
983544-1	1976	Daily intake of nitrate and nitrate by German Federal Republic resident was calculated to 75 mg NO3- and 3.3 mg NO2-.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
16659360-5	1975	The response to glucose is seen over a wide range of external NO(3) (-) concentrations.Nitrate reductase activity is lost rapidly when nitrate is withdrawn from the induction medium.	Nitrates	135-142	nitrate reductase [NADH] 1	Zea mays	87-104
2016-2	1975	Maximal levels of free water clearance/clomerular filtration rate (CH2O/GFR) averaged 8.4% with nitrate loading and 14.4% with saline loading.	Nitrates	96-103	Rap guanine nucleotide exchange factor 5	Homo sapiens	67-75
16659373-6	1975	The pattern of induction of nitrate reductase was coincident with the pattern of nitrate uptake as a function of time and increasing nitrate concentrations.	Nitrates	81-88	nitrate reductase [NADH] 1	Zea mays	28-45
16659373-7	1975	The rate of induction of nitrate reductase was regulated by the rate of nitrate flux.Washing the roots for 2 hours enhances nitrate uptake by 2.5-fold over the nonwashed tissue.	Nitrates	72-79	nitrate reductase [NADH] 1	Zea mays	25-42
170914-6	1975	The significance of the enzyme in conjunction with glutamine synthetase in the assimilation of nitrate by roots is discussed.	Nitrates	95-102	glutamate-ammonia ligase	Homo sapiens	51-71
236776-2	1975	Also dithionite, used to reduce benzylviologen and FMN, inactivates nitrate reductase: however, FMN at an optimal concentration and nitrate, added before the dithionite, protect the enzyme against this inactivation.	Nitrates	68-75	formin 1	Homo sapiens	51-54
236776-2	1975	Also dithionite, used to reduce benzylviologen and FMN, inactivates nitrate reductase: however, FMN at an optimal concentration and nitrate, added before the dithionite, protect the enzyme against this inactivation.	Nitrates	68-75	formin 1	Homo sapiens	96-99
16658419-3	1973	Experiments were conducted to determine whether the decrease in nitrate reductase activity was due to reduced levels of nitrate in the tissue, direct inactivation of the enzyme by low leaf water potentials, or to changes in rates of synthesis or decay of the enzyme.Although tissue nitrate content decreased with the onset of desiccation, it did not continue to decline with tissue desiccation and loss of enzyme activity.	Nitrates	120-127	nitrate reductase [NADH] 1	Zea mays	64-81
24430370-2	1975	over the growing season.The level of nitrate-reductase activity generally paralleled the concentration of nitrate in the leaf tissue over the entire growing season.	Nitrates	37-44	chalcone reductase CHR1	Glycine max	45-54
16658419-4	1973	Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity.	Nitrates	73-80	nitrate reductase [NADH] 1	Zea mays	0-17
16658419-4	1973	Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity.	Nitrates	73-80	nitrate reductase [NADH] 1	Zea mays	157-174
16658419-4	1973	Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity.	Nitrates	114-121	nitrate reductase [NADH] 1	Zea mays	0-17
16658419-4	1973	Nitrate reductase activity recovered when the plants were rewatered with nitrate-free medium, suggesting that the nitrate in the plant was adequate for high nitrate reductase activity.	Nitrates	114-121	nitrate reductase [NADH] 1	Zea mays	157-174
16657550-1	1970	Nitrate reductase activity was induced by nitrate in green corn (Zea mays) leaves in either light or darkness.	Nitrates	42-49	nitrate reductase [NADH] 1	Zea mays	0-17
16658530-1	1973	In a study on 3-day maize (Zea mays) seedlings, grown on nitrate, requirements were established for the maximum extraction and optimum stabilization of nitrate reductase in vitro.	Nitrates	57-64	nitrate reductase [NADH] 1	Zea mays	152-169
16658530-6	1973	A high level of nitrate (approximately 100 mm) was required to saturate the induction of nitrate reductase in the root tip, mature root, and scutellum.	Nitrates	16-23	nitrate reductase [NADH] 1	Zea mays	89-106
16658530-7	1973	The concentration of nitrate required to give half the maximum level of enzyme induced was the same for each region (29 mm).After leaf expansion, more than 90% of the nitrate reductase was in the shoot, mainly in the leaf blade, and a marked decrease occurred in the level of the enzyme in the scutellum.	Nitrates	21-28	nitrate reductase [NADH] 1	Zea mays	167-184
16658531-10	1973	The activity of the nitrate reductase inactivating enzyme was not influenced by nitrate and was also found in the mature root of minus nitrate-grown seedlings.	Nitrates	80-87	nitrate reductase [NADH] 1	Zea mays	20-37
16657912-4	1972	Soybean contains an active nitrate reductase in roots and leaves, but the low specific activity of this enzyme in sunflower leaves indicates a dependency upon the roots for nitrate reduction.	Nitrates	27-34	chalcone reductase CHR1	Glycine max	35-44
16657912-6	1972	Nitrate reductase activity in leaves of nitrate-supplied soybean and sunflower follows closely the distribution of nitrate reductase.	Nitrates	40-47	inducible nitrate reductase [NADH] 1	Glycine max	0-17
16657912-6	1972	Nitrate reductase activity in leaves of nitrate-supplied soybean and sunflower follows closely the distribution of nitrate reductase.	Nitrates	40-47	chalcone reductase CHR1	Glycine max	8-17
16657913-6	1972	Nitrate roots also maintain a high level of NADPH, presumably by the stimulatory effect of nitrate utilization on glucose-6-phosphate dehydrogenase activity.	Nitrates	0-7	glucose-6-phosphate dehydrogenase	Glycine max	114-147
16657913-6	1972	Nitrate roots also maintain a high level of NADPH, presumably by the stimulatory effect of nitrate utilization on glucose-6-phosphate dehydrogenase activity.	Nitrates	91-98	glucose-6-phosphate dehydrogenase	Glycine max	114-147
16657914-9	1972	Maximum total activity shifted to leaf positions lower in the plant canopy with later growth stages.Nitrate reductase activity of soybeans grown in hydroponic systems was significantly higher than activity of adjacent soil grown plants at later growth stages, which suggested that under normal field conditions the potential for nitrate utilization may not be realized.	Nitrates	329-336	inducible nitrate reductase [NADH] 1	Glycine max	100-117
4396143-2	1971	The purified enzyme was specific for NADPH and catalyzed reduction of nitrate, cytochrome c from isolated mitochondria of Aspergillus, and mammalian cytochrome c.	Nitrates	70-77	cytochrome c, somatic	Homo sapiens	149-161
4993525-0	1970	[Effect of nitrates in products of vegetable origin on methemoglobin formation].	Nitrates	11-19	hemoglobin subunit gamma 2	Homo sapiens	55-68
5068711-0	1972	Methemoglobin levels in infants in an area with high nitrate water supply.	Nitrates	53-60	hemoglobin subunit gamma 2	Homo sapiens	0-13
4397909-0	1971	The development of methemoglobin in mothers and newborn infants from nitrate in water supplies.	Nitrates	69-76	hemoglobin subunit gamma 2	Homo sapiens	19-32
5557824-0	1971	[Regulation of plant glutamine synthetase by ammonium and nitrate].	Nitrates	58-65	glutamate-ammonia ligase	Homo sapiens	21-41
4393266-1	1970	In vitro assembly or complementation of a hybrid assimilatory nitrate reductase was attained by mixing a preparation of nitrate-induced N. crassa mutant nit-1 specifically with acid-treated (pH 2.5) bovine milk or intestinal xanthine oxidase, rabbit liver aldehyde oxidase, or chicken liver xanthine dehydrogenase.	Nitrates	62-69	xanthine dehydrogenase	Gallus gallus	291-313
17774405-1	1968	The interrelations and time-dependence of nitrate, nitrite, and ammonia in a deep basin of the Baltic Sea yield a measurement of stagnation history and may provide a means of prediction of resupply of nutrients to the upper productive layers.	Nitrates	42-49	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	102-105
34050740-4	2021	Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth.	Nitrates	133-140	Plant regulator RWP-RK family protein	Arabidopsis thaliana	33-37
33743462-2	2021	In this study, a three-dimensional model of a large coal waste rock dump constructed in the Elk Valley, British Columbia, Canada was developed to capture the impact of construction history (1981-2012) and solute transport on nitrate (NO3-) release over a 100-year timeframe.	Nitrates	225-232	NBL1, DAN family BMP antagonist	Homo sapiens	234-237
34043471-7	2021	In skeletal muscle, nitrate treatment upregulated expression of genes central to nutrient sensing (mtor), redox signaling (nrf2a) and muscle differentiation (sox6).	Nitrates	20-27	nfe2 like bZIP transcription factor 2a	Danio rerio	123-128
34043471-7	2021	In skeletal muscle, nitrate treatment upregulated expression of genes central to nutrient sensing (mtor), redox signaling (nrf2a) and muscle differentiation (sox6).	Nitrates	20-27	SRY-box transcription factor 6	Danio rerio	158-162
16742412-11	1966	Nitrite reductase is induced by nitrite and only indirectly by nitrate.	Nitrates	63-70	ferredoxin--nitrite reductase, chloroplastic	Raphanus sativus	0-17
20294121-0	1947	Studies on reactions relating to carbohydrates and polysaccharides; effect of hot alkali on the nitrates of starch, amylose, and amylopectin.	Nitrates	96-104	alcohol dehydrogenase iron containing 1	Homo sapiens	78-81
33736152-6	2021	Organic aerosol (OA) and sulfate were dominant contributor of PM1 in summer, whereas OA and nitrate primarily contribution to the increase of PM1 mass loading in spring and winter.	Nitrates	92-99	transmembrane protein 11	Homo sapiens	142-145
34050740-4	2021	Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth.	Nitrates	133-140	NIN like protein 7	Arabidopsis thaliana	42-46
34050740-4	2021	Unlike other nlp single mutants, nlp2 and nlp7 single mutants showed a reduction in shoot fresh weight when grown in the presence of nitrate as the sole nitrogen source, indicating that NLP2, like NLP7, plays a major role in vegetative growth.	Nitrates	133-140	Plant regulator RWP-RK family protein	Arabidopsis thaliana	186-190
34050740-7	2021	Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis.	Nitrates	13-20	Plant regulator RWP-RK family protein	Arabidopsis thaliana	93-97
34050740-7	2021	Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis.	Nitrates	13-20	Plant regulator RWP-RK family protein	Arabidopsis thaliana	162-166
34050740-7	2021	Importantly, nitrate utilization was almost completely abolished in the nlp septuple mutant (nlp2 nlp4 nlp5 nlp6 nlp7 nlp8 nlp9), suggesting that NLPs other than NLP2 and NLP7 also assist in the regulation of nitrate-inducible gene expression and nitrate-dependent promotion of vegetative growth in Arabidopsis.	Nitrates	13-20	NIN like protein 7	Arabidopsis thaliana	171-175
33990989-2	2021	By employing ab initio molecular dynamics (AIMD) method, we studied the effects of the proton transfer and the rotation of the nitrates on the vibrational profiles of HNO3 (NO3 - )(H2 O)n (n = 0-2).	Nitrates	127-135	NBL1, DAN family BMP antagonist	Homo sapiens	168-171
34038101-2	2021	The balance of water coordination and the multitude of bonding of the weakly coordinated nitrate lead to a progressive change in the coordination number of the Cd2+ ions from eight to seven to six without great perturbation to the 4-fold interpenetration three-dimensional framework.	Nitrates	89-96	CD2 molecule	Homo sapiens	160-163
33903869-1	2021	Herein, we describe the nonlinear processes for the formation of thin films of the PbS-CdS system using chemical bath deposition with a gradual change in the cadmium nitrate content in the reaction mixture.	Nitrates	166-173	cholinergic receptor muscarinic 3	Homo sapiens	83-86
33982797-9	2021	Nitrate-containing versus placebo juice significantly lowered CIMT [-0.06 (95% Confidence Interval -0.12, -0.01), p=0.034], an overall difference of ~8% relative to baseline; but had no effect on carotid diameter (CD) or carotid stiffness (CS).	Nitrates	0-7	CIMT	Homo sapiens	62-66
33966117-6	2021	At 90% WHC, Met + C treatment significantly lessened concentrations of NH4+ and NO3-, nonetheless improved N2O compared to Met treatment.	Nitrates	80-84	SAFB like transcription modulator	Homo sapiens	12-15
34025702-10	2021	A key indicator of biostimulant performance was increased nitrate content in barley shoot tissue 22 days after N fertilizer application (+17.9-72.2%), that was associated with gene upregulation of root nitrate transporters (NRT1.1, NRT2.1, and NRT1.5).	Nitrates	58-65	putative low affinity nitrate transporter	Hordeum vulgare	224-228
33482555-1	2021	The effective control and management of nitrate (NO3-) pollution requires the identification of the sources of NO3- pollution in groundwater and quantification of their contribution rates.	Nitrates	40-47	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
33482555-1	2021	The effective control and management of nitrate (NO3-) pollution requires the identification of the sources of NO3- pollution in groundwater and quantification of their contribution rates.	Nitrates	40-47	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
33963398-6	2021	Moreover, higher photorespiration and nitrate accumulation were determined in these plants relative to the untransformed control, indicating that overexpression of Trx m favors the photorespiratory N cycle rather than primary nitrate assimilation.	Nitrates	38-45	thioredoxin H-type 1	Nicotiana tabacum	164-167
33758916-3	2021	Following N removal, plants activate their Nitrogen Starvation Response (NSR) being characterized in particular by the activation of very high-affinity nitrate transport systems (NRT2.4, NRT2.5) and other sentinel genes involved in N-remobilization such as GDH3.	Nitrates	152-159	nitrate transporter 2:1	Arabidopsis thaliana	179-183
33758916-3	2021	Following N removal, plants activate their Nitrogen Starvation Response (NSR) being characterized in particular by the activation of very high-affinity nitrate transport systems (NRT2.4, NRT2.5) and other sentinel genes involved in N-remobilization such as GDH3.	Nitrates	152-159	nitrate transporter2.5	Arabidopsis thaliana	187-193
33758916-5	2021	First, HHOs directly repress the high-affinity nitrate transporters, NRT2.4 and NRT2.5.	Nitrates	47-54	nitrate transporter 2:1	Arabidopsis thaliana	69-73
33601051-3	2021	We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels.	Nitrates	86-93	nitrate transporter 1.1	Arabidopsis thaliana	107-113
33831352-3	2021	Here, we discovered that, independent of nitrogen assimilation, nitrate and ammonium function as primary nitrogen signals to activate TOR in the Arabidopsis leaf primordium.	Nitrates	64-71	target of rapamycin	Arabidopsis thaliana	134-137
33831352-5	2021	Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions.	Nitrates	15-22	RHO-related protein from plants 2	Arabidopsis thaliana	113-117
33831352-5	2021	Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions.	Nitrates	15-22	RHO-related protein from plants 2	Arabidopsis thaliana	146-150
33831352-5	2021	Interestingly, nitrate, ammonium, and glutamine all activate the small GTPase Rho-related protein from plants 2 (ROP2), and constitutively active ROP2 restores TOR activation under nitrogen-starvation conditions.	Nitrates	15-22	target of rapamycin	Arabidopsis thaliana	160-163
33601051-8	2021	The dynamic interactions between CNGC15 and NRT1.1 therefore controlled the channel activity and Ca2+-influx in a nitrate-dependent manner.	Nitrates	114-121	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	33-39
33601051-8	2021	The dynamic interactions between CNGC15 and NRT1.1 therefore controlled the channel activity and Ca2+-influx in a nitrate-dependent manner.	Nitrates	114-121	nitrate transporter 1.1	Arabidopsis thaliana	44-50
33601051-3	2021	We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels.	Nitrates	187-194	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	70-76
33601051-3	2021	We report here that a cyclic nucleotide-gated channel (CNGC) protein, CNGC15, and the nitrate transceptor (NRT1.1) constitute a molecular switch that controls calcium influx depending on nitrate levels.	Nitrates	187-194	nitrate transporter 1.1	Arabidopsis thaliana	107-113
33601051-4	2021	CNGC15 gene expression was induced by nitrate and the CNGC15 protein was localized to the plasma membrane after establishment of young seedlings.	Nitrates	38-45	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	0-6
33601051-5	2021	Disruption of CNGC15 gene resulted in the loss of nitrate-induced Ca2+ signature (primary nitrate responses) and retarded root growth, reminiscent to the phenotype observed in the nrt1.1 mutant.	Nitrates	50-57	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	14-20
33601051-5	2021	Disruption of CNGC15 gene resulted in the loss of nitrate-induced Ca2+ signature (primary nitrate responses) and retarded root growth, reminiscent to the phenotype observed in the nrt1.1 mutant.	Nitrates	90-97	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	14-20
33601051-7	2021	Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel.	Nitrates	124-131	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	13-19
33601051-7	2021	Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel.	Nitrates	124-131	nitrate transporter 1.1	Arabidopsis thaliana	20-26
33601051-7	2021	Importantly, CNGC15-NRT1.1 interaction silenced the channel activity of the heterocomplex that dissociated upon the rise in nitrate levels leading to re-activation of the CNGC15 channel.	Nitrates	124-131	cyclic nucleotide-gated channel 15	Arabidopsis thaliana	171-177
33210841-0	2021	HBI1-TCP20 interaction positively regulates the CEPs-mediated systemic nitrate acquisition.	Nitrates	71-78	chaperonin containing TCP1 subunit 6A	Homo sapiens	5-10
33460896-7	2021	Metagenomics analysis revealed that the preferred metabolic pathway of nitrogen was from ammonium to glutamate via glutamine, and the enzymes governing this transformation were glutamine synthetase and glutamate synthetase; while in nitrate based amendment, the conversion from nitrite to ammonium was restrained by the low abundance of nitrite reductase enzyme and therefore retarded the TPH degradation rate.	Nitrates	233-240	glutamate-ammonia ligase	Homo sapiens	177-197
33624251-2	2021	The GATA transcription factors belonging to type IV zinc-finger proteins, play a significant role in regulating light morphogenesis, nitrate assimilation, and organ development in plants.	Nitrates	133-140	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	4-8
33579566-4	2021	Batch tests demonstrated that efficient PD with nitrate-to-nitrite transformation ratio of 97.67% supplying stable nitrite for anammox, and phosphorus was mainly removed using nitrate as electron acceptor via DPR with the ideal phosphorus release/uptake rate (7.73/22.17 mgP/gVSS/h).	Nitrates	176-183	matrix Gla protein	Homo sapiens	271-274
33949893-8	2021	RESULTS: Spontaneous preterm birth at 20-31 wk was increased in association with tap water nitrate concentrations during pregnancy of 5 to <10mg/L [odds ratio (OR)=1.47; 95% confidence interval (CI): 1.29, 1.67] and >=10mg/L (OR=2.52; 95% CI: 1.49, 4.26) compared with <5mg/L (as nitrogen).	Nitrates	91-98	nuclear RNA export factor 1	Homo sapiens	81-84
33949893-12	2021	Notably, we estimated modestly increased odds associated with tap water nitrate concentrations of 5 to <10mg/L (below the federal drinking water standard of 10mg/L) relative to <5mg/L.	Nitrates	72-79	nuclear RNA export factor 1	Homo sapiens	62-65
33934458-5	2021	The Diatom/Dino trend is explained by an altered nutrient composition caused by a decadal increase in anthropogenic input, where nitrate increased rapidly while ammonium and phosphate were relatively constant.	Nitrates	129-136	damage induced long noncoding RNA	Homo sapiens	11-15
33934458-7	2021	Our models predict that the Diatom/Dino ratio will further increase with increasing anthropogenic input and global warming in subtropical estuarine ecosystems with nitrate as the dominant inorganic nitrogen; its ecological consequences are worthy of further investigation.	Nitrates	164-171	damage induced long noncoding RNA	Homo sapiens	35-39
33210841-4	2021	Here, we demonstrate that the transcription factors HBI1 and TCP20 play important roles in plant growth and development in response to fluctuating nitrate supply.	Nitrates	147-154	chaperonin containing TCP1 subunit 6A	Homo sapiens	61-66
33210841-5	2021	HBI1 physically interacts with TCP20, and this interaction was enhanced by the nitrate starvation.	Nitrates	79-86	chaperonin containing TCP1 subunit 6A	Homo sapiens	31-36
33210841-7	2021	Mutation in HBIs and/or TCP20 resulted in impaired systemic nitrate acquisition response.	Nitrates	60-67	chaperonin containing TCP1 subunit 6A	Homo sapiens	24-29
33210841-8	2021	Our solid genetic and molecular evidences strongly indicate that the HBI1-TCP20 module positively regulates the CEPs-mediated systemic nitrate acquisition.	Nitrates	135-142	chaperonin containing TCP1 subunit 6A	Homo sapiens	74-79
33927257-1	2021	An increased nitrate (NO3-) concentration in groundwater has been a rising issue on a global scale in recent years.	Nitrates	13-20	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
33713800-3	2021	We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR).	Nitrates	56-63	xanthine dehydrogenase	Rattus norvegicus	173-196
33713800-3	2021	We showed that at conditions of increased NO need, this nitrate reservoir is used in situ to generate nitrite and NO, at least in part via the nitrate reductase activity of xanthine oxidoreductase (XOR).	Nitrates	56-63	xanthine dehydrogenase	Rattus norvegicus	198-201
33713800-8	2021	During the course of the overall experiment there was a gradual increase of XOR expression in muscle tissue, which likely led to enhanced nitrate to nitrite reduction.	Nitrates	138-145	xanthine dehydrogenase	Rattus norvegicus	76-79
33947005-1	2021	Beneficial metabolic effects of inorganic nitrate (NO3-) and nitrite (NO2-) in type 2 diabetes mellitus (T2DM) have been documented in animal experiments; however, this is not the case for humans.	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
33872506-1	2021	Electrocatalytic conversion of nitrate (NO3-) into ammonia can not only eliminate harmful pollutant but also provide a green method for a low-temperature ammonia synthesis.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
33886581-5	2021	In contrast, in Pkd1RC/RC mice, sodium nitrate supplementation increased serum nitrate/nitrite levels by ~25-fold in the high dose group (P<0.001), but kidney enlargement and percentage cyst area was not altered, regardless of dose.	Nitrates	39-46	polycystin 1, transient receptor potential channel interacting	Mus musculus	16-22
33900460-8	2021	Most nitrate variation has been recorded at or near the water table where concentrations have ranged between 3.47 and 5.88 mg NO3-N/L, and annual maxima have occurred in late winter/spring, which coincides with when most nitrate leaching occurs from agricultural land.	Nitrates	5-12	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
33849366-9	2021	CONCLUSIONS: Water, heat, and excipients" nitrite and nitrate levels are the key players, which should collectively exist, to cause NDMA formation during MET tablets manufacturing.	Nitrates	54-61	SAFB like transcription modulator	Homo sapiens	154-157
33422844-1	2021	Nitrogen losses from intensive agricultural production may end up as high nitrate (NO3-) concentrations in groundwater, with a long-term impact on groundwater quality.	Nitrates	74-81	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
33787201-4	2021	The platinum salt undergoes a vivid change in color and luminescence upon exposure to aqueous NO3- anions at pH <= 0 caused by substitution of the PF6- anions by aqueous NO3-.	Nitrates	94-98	sperm associated antigen 17	Homo sapiens	147-150
33851500-2	2021	The cytochrome P450 TxtE nitrates the indole 4-position of L-tryptophan at room temperature using NO, O 2 and NADPH, and has potential to be developed into a useful aromatic nitration biocatalyst.	Nitrates	25-33	2,4-dienoyl-CoA reductase 1	Homo sapiens	110-115
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	221-224
33924662-2	2021	The efficiency of Pb(II) removal from aqueous nitrate solutions was considered as a function of the composition of membrane (effect of polymer, plasticizer, and carrier), feed (effect of initial metal concentration and presence of other metal ions) and stripping phases, and temperature of the process conducting.	Nitrates	46-53	submaxillary gland androgen regulated protein 3B	Homo sapiens	18-24
33840873-4	2021	By comparing chemical constituents between clean and polluted episodes, we find that the elevated PM1 mass concentration during pollution events should be largely attributable to significant increases in organic matter (OM) and inorganic aerosols like sulfate, nitrate, and ammonium (SNA), indicative of the critical role of primary emissions and secondary aerosols in elevating PM1 pollution levels.	Nitrates	261-268	transmembrane protein 11	Homo sapiens	98-101
33826745-0	2021	Different DNA-binding specificities of NLP and NIN transcription factors underlie nitrate-induced control of root nodulation.	Nitrates	82-89	nin	Lotus japonicus	47-50
33826745-3	2021	Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive.	Nitrates	157-164	nin	Lotus japonicus	16-32
33826745-3	2021	Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive.	Nitrates	157-164	nin	Lotus japonicus	34-37
33826745-3	2021	Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive.	Nitrates	193-200	nin	Lotus japonicus	16-32
33826745-3	2021	Although legume NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors have recently been identified, understanding how nodulation is controlled by nitrate, a fundamental question for nitrate-mediated transcriptional regulation of symbiotic genes, remains elusive.	Nitrates	193-200	nin	Lotus japonicus	34-37
33826745-4	2021	Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression.	Nitrates	45-52	NLP1	Lotus japonicus	105-111
33826745-4	2021	Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression.	Nitrates	147-154	NLP1	Lotus japonicus	105-111
33826745-4	2021	Here, we show that two Lotus japonicus NLPs, NITRATE UNRESPONSIVE SYMBIOSIS 1 (NRSYM1)/LjNLP4 and NRSYM2/LjNLP1, have overlapping functions in the nitrate-induced control of nodulation and act as master regulators for nitrate-dependent gene expression.	Nitrates	218-225	NLP1	Lotus japonicus	105-111
33450066-3	2021	Whereas ALDH2 is known to directly activate organic nitrates in vessels, the contribution of vascular CYPs is unknown and was studied here.	Nitrates	52-60	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	8-13
33515769-0	2021	CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis.	Nitrates	95-102	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	0-6
33515769-7	2021	Wild-type CPSF30-L rescued defects in APA and nitrate metabolism, but m6A-binding defective mutants did not.	Nitrates	46-53	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	10-16
33515769-8	2021	Taken together, our results demonstrated that m6A modification regulates APA in Arabidopsis, and revealed that m6A reader CPSF30-L affects nitrate signaling by controlling APA.	Nitrates	139-146	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	122-128
33393351-5	2021	Extrapolation of the experimental data resulted in values for all the nitrate-bands of the afreea i.e. fully hydrated NO3-(aq).	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
33168291-0	2021	A novel strategy for sequential reduction of nitrate into nitrogen by CO2 anion radical: Experimental study and DFT calculation.	Nitrates	45-52	complement C2	Homo sapiens	70-73
33168291-1	2021	In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate.	Nitrates	181-188	complement C2	Homo sapiens	38-41
33168291-1	2021	In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate.	Nitrates	181-188	complement C2	Homo sapiens	57-60
33168291-1	2021	In order to expand the application of CO2 anion radical (CO2-), as a novel green reductant in the control of environmental pollution, CO2- radical was induced into the reduction of nitrate.	Nitrates	181-188	complement C2	Homo sapiens	57-60
33168291-2	2021	The reduction efficiency, products and mechanism of nitrate or nitrite by CO2- radical were investigated based on the results of batch experiments and theoretical calculation using density functional theory (DFT) methods, respectively.	Nitrates	52-59	complement C2	Homo sapiens	74-77
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	41-48	complement C2	Homo sapiens	62-65
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	41-48	complement C2	Homo sapiens	221-224
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	62-65
33115598-1	2021	BACKGROUND: Vitamin C may enhance nitric oxide (NO) production through stepwise reduction of dietary nitrate (NO3) to nitrite (NO2) to NO.	Nitrates	101-108	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	62-65
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	221-224
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	62-65
33168291-3	2021	It was found that: (1) the efficiency of nitrate reduction by CO2- radical from the HCOOH/UV system was far lower than that of nitrite under the same reaction conditions, (2) the rate-control step of nitrate reduction by CO2- radical was the transformation process of nitrate into nitrite with an activation energy of 23.9 kcal/mol, (3) the final products of nitrate reduction were mainly composed of nitrogen (N2).	Nitrates	200-207	complement C2	Homo sapiens	221-224
33168291-4	2021	On this basis, a novel strategy of rapid reduction of nitrate into N2 using CO2- radical was proposed.	Nitrates	54-61	complement C2	Homo sapiens	76-79
33168291-5	2021	Specifically, nitrate was firstly reduced into nitrite with the assistance of Zn/Ag bimetal, and then nitrite was further reduced into N2 by CO2- radical.	Nitrates	14-21	complement C2	Homo sapiens	141-144
33168291-7	2021	This work provided a promising approach for the reduction of nitrate into nitrogen with high efficiency and high N2 selectivity by CO2- radical.	Nitrates	61-68	complement C2	Homo sapiens	131-134
33785324-12	2021	CONCLUSION: These findings support the hypothesis that drinking high nitrate water increases oral nitrate-reducing bacteria, which likely results in increased NOC.	Nitrates	69-76	nocturnin	Homo sapiens	159-162
33868355-0	2021	Regulation of Lateral Root Development by Shoot-Sensed Far-Red Light via HY5 Is Nitrate-Dependent and Involves the NRT2.1 Nitrate Transporter.	Nitrates	80-87	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	73-76
33868355-9	2021	Consistently, a loss-of-function mutant of a nitrate transporter gene NRT2.1 lacked low R:FR-induced lateral root reduction and its root growth was hypersensitive to low nitrate.	Nitrates	45-52	nitrate transporter 2:1	Arabidopsis thaliana	70-74
33868355-10	2021	ELONGATED HYPOCOTYL5 (HY5) plays an important role in the root response to low R:FR and we found that it was less sensitive to low nitrate conditions with regards to lateral root growth.	Nitrates	131-138	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	10-20
33868355-10	2021	ELONGATED HYPOCOTYL5 (HY5) plays an important role in the root response to low R:FR and we found that it was less sensitive to low nitrate conditions with regards to lateral root growth.	Nitrates	131-138	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	22-25
33868355-11	2021	In addition, we found that low R:FR increases NRT2.1 expression and that low nitrate enhances HY5 expression.	Nitrates	77-84	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	94-97
33090485-0	2021	Involvement of boron transporter BOR1 in growth under low-boron and high-nitrate conditions in Arabidopsis thaliana.	Nitrates	73-80	HCO3- transporter family	Arabidopsis thaliana	33-37
33090485-2	2021	It has been reported that nitrate (NO3 - ) concentrations significantly influence B concentrations in leaves and BOR1 mRNA accumulation in roots.	Nitrates	26-33	HCO3- transporter family	Arabidopsis thaliana	113-117
33127147-12	2021	Vertically increased NO3 radicals may imply the formation of nitrate aerosols and further increase the nitrate content in high- altitude particulate matter.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
33127147-12	2021	Vertically increased NO3 radicals may imply the formation of nitrate aerosols and further increase the nitrate content in high- altitude particulate matter.	Nitrates	103-110	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
33785324-12	2021	CONCLUSION: These findings support the hypothesis that drinking high nitrate water increases oral nitrate-reducing bacteria, which likely results in increased NOC.	Nitrates	98-105	nocturnin	Homo sapiens	159-162
33187786-13	2021	Overall, the results suggest that EVOH-g-DMAC NFM is efficient, low-cost (13 USD/m3) and recyclable material for sustainable removal of nitrate from dairy manure wastewater without requiring any ionic strength or pH adjustment.	Nitrates	136-143	neurofilament medium chain	Homo sapiens	46-49
33838420-6	2021	Results revealed that pinewood-derived biochar had its maximum performance at pH 2, with predicted equilibrium uptakes of 20.5 and 4.20 mg/g for phosphate and nitrate, respectively at initial solute concentrations of 60 mg/L within 360 min.	Nitrates	159-166	phenylalanine hydroxylase	Homo sapiens	78-80
33598673-3	2021	The mononitrate species formed is then further reacted with TMS2Pz to doubly deoxygenate nitrate and form [(L-)Ni(NO)]2, dimeric via bridging pyrazolate with bent nitrosyl ligands, representing a two-electron reduction of coordinated nitrate.	Nitrates	8-15	serine incorporator 1	Homo sapiens	60-64
33868355-14	2021	Together our results show that nitrate signaling can repress low R:FR responses and that this involves signaling via HY5 and NRT2.1.	Nitrates	31-38	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	117-120
33868355-14	2021	Together our results show that nitrate signaling can repress low R:FR responses and that this involves signaling via HY5 and NRT2.1.	Nitrates	31-38	nitrate transporter 2:1	Arabidopsis thaliana	125-129
33721901-4	2021	Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio.	Nitrates	95-102	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	14-18
33333400-7	2021	The results of nitrate isotopes indicated that NO3- mainly originated from soil N nitrogen, chemical fertilizer, and manure and sewage wastes.	Nitrates	15-22	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
33796477-6	2021	Our results revealed that CD18low mice infected with Pb18 survived during the time analyzed; their lungs showed fewer granulomas, a lower fungal load, lower levels of nitrate, and production of high levels of IgG1 in comparison to WT animals.	Nitrates	167-174	integrin beta 2	Mus musculus	26-30
33721901-4	2021	Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio.	Nitrates	95-102	Raffinose synthase family protein	Arabidopsis thaliana	23-28
33721901-4	2021	Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio.	Nitrates	202-209	glutamine-dependent asparagine synthase 1	Arabidopsis thaliana	14-18
33721901-4	2021	Expression of DIN6 and DIN10, the carbon (C) starvation-responsive genes, was upregulated when nitrate was oversupplied under Pi starvation, which suggested that the plants recognized the oversupply of nitrate as C starvation stress because of the reduction in the C/N ratio.	Nitrates	202-209	Raffinose synthase family protein	Arabidopsis thaliana	23-28
33687628-3	2021	Nitrate reduction resulted in the production of nitrogen gas, while sulfate formed due to sulfide oxidation.	Nitrates	0-7	gastrin	Homo sapiens	57-60
33264477-1	2021	Diatoms are among the few eukaryotes known to store nitrate (NO3 - ) and to use it as an electron acceptor for respiration in the absence of light and O2 .	Nitrates	52-59	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
32130090-1	2021	The aim of this study was to determine the effect of five days dietary nitrate (NO3-) consumption on exercise tolerance and thermoregulation during cycling in hot, dry conditions.	Nitrates	71-78	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
33109332-6	2021	The crystallographic structure of lysozyme with the IL of ethylammonium nitrate present confirmed the loop region was extended, and identified three specific binding sites with nitrate ions, and that the positively charged areas were IL sensitive regions.	Nitrates	72-79	lysozyme	Homo sapiens	34-42
33284304-11	2021	Compared with the low humidity period, both PM1 and PM2.5 show higher mass fraction of secondary inorganic aerosols (SIA, mainly as nitrate, sulfate and ammonium) and secondary organic aerosols (SOA) during high humidity and fog episodes.	Nitrates	132-139	transmembrane protein 11	Homo sapiens	44-47
33462996-1	2021	In order to reduce nitrate in vivo, the spore-specific respiratory nitrate reductase, Nar1, of Streptomyces coelicolor relies on an active cytochrome bcc-aa3 oxidase supercomplex (bcc-aa3 supercomplex).	Nitrates	19-26	SCO2473	Streptomyces coelicolor A3(2)	67-84
33637855-2	2021	Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots.	Nitrates	229-236	nitrate transporter 1.1	Arabidopsis thaliana	186-192
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Nitrates	106-113	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
33569852-4	2021	Density functional theory (DFT) calculations reproduce experimental results and show that dissociation of nitrate ligands, with ejection of neutral NO2 , is favored for both [UO2 (NO3 )3 ]- and [UO2 (NO3 )2 (O2 )]- .	Nitrates	106-113	NBL1, DAN family BMP antagonist	Homo sapiens	200-203
33686225-6	2021	Collectively, our results identify CEPH as a crucial enzyme in the N-starvation-dependent activation of NRT2.1 and provide molecular and mechanistic insights into how plants regulate high-affinity nitrate uptake at the post-translational level in response to the N environment.	Nitrates	197-204	nitrate transporter 2:1	Arabidopsis thaliana	104-110
33331676-0	2021	Abscisic acid signaling negatively regulates nitrate uptake via phosphorylation of NRT1.1 by SnRK2s in Arabidopsis.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	83-89
33331676-6	2021	Strikingly, SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1 (NRT1.1) in vitro and in vivo.	Nitrates	76-83	nitrate transporter 1.1	Arabidopsis thaliana	96-118
33331676-6	2021	Strikingly, SnRK2.2/2.3/2.6 proteins interacted with and phosphorylated the nitrate transceptor NITRATE TRANSPORTER1.1 (NRT1.1) in vitro and in vivo.	Nitrates	76-83	nitrate transporter 1.1	Arabidopsis thaliana	120-126
33331676-7	2021	The phosphorylation of NRT1.1 by SnRK2s resulted in a significant decrease of nitrate uptake and impairment of root growth.	Nitrates	78-85	nitrate transporter 1.1	Arabidopsis thaliana	23-29
33686225-0	2021	A type 2C protein phosphatase activates high-affinity nitrate uptake by dephosphorylating NRT2.1.	Nitrates	54-61	nitrate transporter 2:1	Arabidopsis thaliana	90-94
33686225-1	2021	The nitrate transporter NRT2.1, which plays a central role in high-affinity nitrate uptake in roots, is activated at the post-translational level in response to nitrogen (N) starvation1,2.	Nitrates	4-11	nitrate transporter 2:1	Arabidopsis thaliana	24-28
33686225-3	2021	Here, we show that a type 2C protein phosphatase, designated CEPD-induced phosphatase (CEPH), activates high-affinity nitrate uptake by directly dephosphorylating Ser501 of NRT2.1, a residue that functions as a negative phospho-switch in Arabidopsis2.	Nitrates	118-125	nitrate transporter 2:1	Arabidopsis thaliana	173-179
33637855-2	2021	Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots.	Nitrates	229-236	nitrate transporter 1.1	Arabidopsis thaliana	193-199
33637855-2	2021	Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots.	Nitrates	261-268	nitrate transporter 1.1	Arabidopsis thaliana	186-192
33637855-2	2021	Here, we show that a genome-wide association study using Arabidopsis thaliana accessions suggested an association between different magnitudes of N deficiency responses and diversity in NRT1.1/NPF6.3 that encodes a dual-affinity nitrate transporter involved in nitrate uptake by roots.	Nitrates	261-268	nitrate transporter 1.1	Arabidopsis thaliana	193-199
33352382-4	2021	Firstly, an acclimation process was used: nitrate was progressively increased in three cultures set at pH 9, 10, or 11.	Nitrates	42-49	phenylalanine hydroxylase	Homo sapiens	103-105
33594566-1	2021	AD2 for efficient nitrate reduction without nitrite accumulation.	Nitrates	18-25	apolipoprotein E	Homo sapiens	0-3
33594566-6	2021	Results showed that strain AD2 removed 98.9% of nitrate-nitrogen (NO3--N) with an initial concentration about 100 mg L-1 in 48 h without nitrite-nitrogen (NO2--N) accumulation.	Nitrates	48-55	apolipoprotein E	Homo sapiens	27-30
33352382-10	2021	Finally, the use of long duration cultures with a highly alkaline pH allowed a nitrate reduction up to pH 11.5 with acetate.	Nitrates	79-86	phenylalanine hydroxylase	Homo sapiens	66-68
33352382-5	2021	This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate.	Nitrates	50-57	phenylalanine hydroxylase	Homo sapiens	74-76
33352382-10	2021	Finally, the use of long duration cultures with a highly alkaline pH allowed a nitrate reduction up to pH 11.5 with acetate.	Nitrates	79-86	phenylalanine hydroxylase	Homo sapiens	103-105
33352382-12	2021	Instead, bacteria used organic matter from inoculum to reduce nitrate at pH 11.5.	Nitrates	62-69	phenylalanine hydroxylase	Homo sapiens	73-75
33352382-5	2021	This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate.	Nitrates	91-98	phenylalanine hydroxylase	Homo sapiens	74-76
33352382-5	2021	This method allowed to observe for the first time nitrate reduction up to pH 10 and 100 mM nitrate with dihydrogen, or up to pH 10 and 400 mM nitrate with acetate.	Nitrates	91-98	phenylalanine hydroxylase	Homo sapiens	74-76
33580260-3	2021	Different from most NRT1 transporters, NRT1.13 does not have the conserved proline residue between transmembrane domains 10 and 11; an essential residue for nitrate transport activity in CHL1/NRT1.1/NPF6.3.	Nitrates	157-164	nitrate transporter 1.1	Arabidopsis thaliana	187-191
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	68-91
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	93-99
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 2:1	Arabidopsis thaliana	105-128
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 2:1	Arabidopsis thaliana	130-134
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	171-177
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 2:1	Arabidopsis thaliana	130-136
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	192-196
33643357-5	2021	An extended photoperiod also improved the root nitrate uptake of by NITRATE TRANSPORTER 1.1 (NRT1.1) and NITRATE TRANSPORTER 2.1 (NRT2.1), whereas the loss of function of NRT1.1/NRT2.1 in the nrt1.1-1/2.1-2 mutants suppressed the expression of the key flowering genes CONSTANS (CO) and FLOWERING LOCUS T (FT), and reduced the sensitivity of the photoperiodic flowering responses to elevated levels of nitrate.	Nitrates	47-54	PEBP (phosphatidylethanolamine-binding protein) family protein	Arabidopsis thaliana	286-303
33580260-3	2021	Different from most NRT1 transporters, NRT1.13 does not have the conserved proline residue between transmembrane domains 10 and 11; an essential residue for nitrate transport activity in CHL1/NRT1.1/NPF6.3.	Nitrates	157-164	nitrate transporter 1.1	Arabidopsis thaliana	39-45
33580260-5	2021	However, when Ser 487 at the corresponding position was converted back to proline, NRT1.13 S487P regained nitrate uptake activity, suggesting that wild-type NRT1.13 cannot transport nitrate but can bind it.	Nitrates	106-113	nitrate transporter 1.1	Arabidopsis thaliana	83-87
33580260-5	2021	However, when Ser 487 at the corresponding position was converted back to proline, NRT1.13 S487P regained nitrate uptake activity, suggesting that wild-type NRT1.13 cannot transport nitrate but can bind it.	Nitrates	182-189	nitrate transporter 1.1	Arabidopsis thaliana	83-87
33560419-0	2021	Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity.	Nitrates	25-32	SNF1 kinase homolog 10	Arabidopsis thaliana	7-14
33560419-0	2021	Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity.	Nitrates	25-32	SLAC1 homologue 3	Arabidopsis thaliana	41-46
33560419-0	2021	Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity.	Nitrates	58-65	SNF1 kinase homolog 10	Arabidopsis thaliana	7-14
33560419-0	2021	Kinase SnRK1.1 Regulates nitrate channel SLAH3 Engaged in Nitrate-Dependent Alleviation of Ammonium Toxicity.	Nitrates	58-65	SLAC1 homologue 3	Arabidopsis thaliana	41-46
33560419-2	2021	Small amounts of NO3- can significantly mitigate ammonium toxicity, and the anion channel SLAC1 homologue 3 (SLAH3) is involved in this process, but the mechanistic detail of how SLAH3 regulates nitrate-dependent alleviation of ammonium toxicity is still largely unknown.	Nitrates	195-202	SLAC1 homologue 3	Arabidopsis thaliana	90-107
33560419-2	2021	Small amounts of NO3- can significantly mitigate ammonium toxicity, and the anion channel SLAC1 homologue 3 (SLAH3) is involved in this process, but the mechanistic detail of how SLAH3 regulates nitrate-dependent alleviation of ammonium toxicity is still largely unknown.	Nitrates	195-202	SLAC1 homologue 3	Arabidopsis thaliana	179-184
33560419-9	2021	Our study reveals that the C-terminal phosphorylation also plays important role in SLAH3 regulation and provides additional insights into nitrate-dependent alleviation of ammonium toxicity in plants.	Nitrates	138-145	SLAC1 homologue 3	Arabidopsis thaliana	83-88
33398446-4	2021	We showed that the removal of nitrate in P. aeruginosa PAO1 was repressed by both the las and rhl systems.	Nitrates	30-37	ATP-dependent RNA helicase RhlB	Pseudomonas aeruginosa PAO1	94-97
33472361-4	2021	Increasing pH and/or decreasing oxygen promoted the conversion of nitrate (NO3-) into NO2- but suppressed the H2O2 formation, suggesting that there was a transition of radicals from oxidizing species like hydroxyl radicals to reducing species like hydrogen atoms and hydrated electrons.	Nitrates	66-73	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	90-97	nitrate transporter 2:1	Arabidopsis thaliana	135-139
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	90-97	nitrate transporter 2:1	Arabidopsis thaliana	166-172
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	90-97	nitrate transporter 2.2	Arabidopsis thaliana	174-180
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	90-97	nitrate transporter 2:1	Arabidopsis thaliana	166-170
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	90-97	nitrate transporter 2:1	Arabidopsis thaliana	166-170
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	99-103	nitrate transporter 2:1	Arabidopsis thaliana	135-139
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	99-103	nitrate transporter 2:1	Arabidopsis thaliana	166-172
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	99-103	nitrate transporter 2.2	Arabidopsis thaliana	174-180
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	99-103	nitrate transporter 2:1	Arabidopsis thaliana	166-170
33582801-1	2021	In Arabidopsis (Arabidopsis thaliana), the High-Affinity Transport System (HATS) for root nitrate (NO3-) uptake depends mainly on four NRT2 NO3- transporters, namely NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	99-103	nitrate transporter 2:1	Arabidopsis thaliana	166-170
33257046-1	2021	A novel integrated bio-electrochemical system with sulfur autotrophic denitrification (SAD) and electrocoagulation (BESAD-EC) system was established to remove nitrate (NO3--N) and phosphorus from contaminated groundwater.	Nitrates	159-166	NBL1, DAN family BMP antagonist	Homo sapiens	168-171
33170463-9	2021	The bivariate plots of NO3 with other ions suggested that the principal origin of nitrate in this study is related to the excess application of fertilizers and sewages.	Nitrates	82-89	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
33539179-1	2021	BACKGROUND: High levels of nitrate (NO3-) in drinking water cause methemoglobinemia in infants; however, few studies have examined the potential effects of low-level exposure on fetal growth, and the results have been inconsistent.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
32026170-7	2021	The groundwater quality of the Bathinda district is a matter of concern due to elevated levels of alkalinity, hardness, fluoride, uranium and nitrate (NO3-).	Nitrates	142-149	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
32767561-1	2021	BACKGROUND: 3,4-dimethylpyrazole phosphate (DMPP) is a nitrification inhibitor which can restrict nitrate (NO3 - ) production.	Nitrates	98-105	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
33399250-6	2021	This coordination is achieved by nitrate-dependent dephosphorylation of the PIN2 auxin efflux carrier at a previously uncharacterized phosphorylation site, leading to subsequent PIN2 lateralization and thereby regulating auxin flow between adjacent tissues.	Nitrates	33-40	telomeric repeat binding factor 1	Homo sapiens	76-80
33399250-6	2021	This coordination is achieved by nitrate-dependent dephosphorylation of the PIN2 auxin efflux carrier at a previously uncharacterized phosphorylation site, leading to subsequent PIN2 lateralization and thereby regulating auxin flow between adjacent tissues.	Nitrates	33-40	telomeric repeat binding factor 1	Homo sapiens	178-182
33487355-5	2021	In conclusion, NLP7 binds to the TAR2 promoter and activates TAR2 expression, thereby promoting nitrate-dependent LR development.	Nitrates	96-103	trace amine associated receptor 2	Homo sapiens	33-37
33047410-4	2021	The delta15 N values are often lower in soil nitrate (NO3 - ) than in ammonium (NH4 + ) due to large isotopic fractionation during nitrification.	Nitrates	45-52	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
33487355-5	2021	In conclusion, NLP7 binds to the TAR2 promoter and activates TAR2 expression, thereby promoting nitrate-dependent LR development.	Nitrates	96-103	trace amine associated receptor 2	Homo sapiens	61-65
33367322-2	2021	In 1-3, the nearly planar molecular structures consisting of two DyIII ions and two L ligands are almost perpendicular to four nitrate ligands, which provides an opportunity to introduce auxiliary ligands (H2O or TPO) at the terminal position along the DyDy orientation of [Dy2].	Nitrates	127-134	thyroid peroxidase	Homo sapiens	213-216
32840941-1	2021	RATIONALE: This study aims to develop a simplified denitrifier method for the delta15 N and delta18 O analysis of nitrate (NO3 - ) in natural water samples combining the method of Zhu et al [14] and the original denitrifier method of Sigman et al [12] .	Nitrates	114-121	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	uncoupling protein 1	Rattus norvegicus	105-125
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	uncoupling protein 1	Rattus norvegicus	127-131
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	134-182
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	184-194
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	PPARG coactivator 1 alpha	Rattus norvegicus	201-231
32950634-2	2021	This study aims at determining effects of long-term nitrate administration on protein and mRNA levels of uncoupling protein 1 (UCP1), peroxisome proliferator activated receptor gamma (PPAR-gamma), and PPAR-gamma coactivator 1 alpha (PGC1-alpha) in epididymal adipose tissue (eAT) of rats with T2D.	Nitrates	52-59	PPARG coactivator 1 alpha	Rattus norvegicus	233-243
32862077-2	2021	By analyzing the spectral absorption characteristics of nitrate, COD, and turbidity standard solutions and the mixtures of them, the absorption spectra in the range of 225-260 nm, 260-320 nm and 320-700 nm were selected as the characteristic spectra of nitrate, COD and turbidity, respectively.	Nitrates	253-260	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	262-265
33432967-8	2021	While MET treatment reduced myocardial nitrates, only MET treatment completely restored microvessel dilation to dobutamine stimulation in the absence of NO and prostanoids (combined inhibition), indicating that MET restored the coronary flow reserve attributable to endothelium-derived hyperpolarisation.	Nitrates	39-47	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	6-9
33128338-0	2021	S-Nitrosylation of Akt by organic nitrate delays revascularization and the recovery of cardiac function in mice following myocardial infarction.	Nitrates	34-41	thymoma viral proto-oncogene 1	Mus musculus	19-22
33297218-8	2021	In contrast, PAH degradation has been reported to increase up to 54% when nitrate is used as electron acceptor in low-temperature biochar-amended sediments.	Nitrates	74-81	phenylalanine hydroxylase	Homo sapiens	13-16
33128338-8	2021	In conclusion, long-term usage of organic nitrate may inactivate Akt to delay ischaemia-induced revascularization and the recovery of cardiac function through NO-mediated S-Nitrosylation.	Nitrates	42-49	thymoma viral proto-oncogene 1	Mus musculus	65-68
33206969-6	2020	By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA.	Nitrates	90-97	periplasmic nitrate reductase subunit alpha	Agrobacterium fabrum str. C58	46-50
33270921-1	2021	Denitrifying woodchip bioreactors (DWBs) are potential low-cost technologies for the removal of nitrate (NO3 - ) in water through denitrification.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
33080433-10	2021	The resulting SECs for Kali river basin are: 2.03 (agricultural), 1.44 (fallow), and 0.92 (settlement) for monsoonal nitrate; while for non-monsoonal nitrate, SECs are 0.51 (agricultural), 0.23 (fallow), and 0.10 (settlement).	Nitrates	117-124	SLAM family member 6	Homo sapiens	23-27
33080433-10	2021	The resulting SECs for Kali river basin are: 2.03 (agricultural), 1.44 (fallow), and 0.92 (settlement) for monsoonal nitrate; while for non-monsoonal nitrate, SECs are 0.51 (agricultural), 0.23 (fallow), and 0.10 (settlement).	Nitrates	150-157	SLAM family member 6	Homo sapiens	23-27
33206969-6	2020	By constructing a mutant strain defective for napA, we demonstrated that the reduction of nitrate to nitrite was catalyzed by the periplasmic nitrate reductase, NapA.	Nitrates	90-97	periplasmic nitrate reductase subunit alpha	Agrobacterium fabrum str. C58	161-165
33048402-0	2020	NITROGEN RESPONSE DEFICIENCY 1 - mediated CHL1 induction contributes to optimized growth performance during altered nitrate availability in Arabidopsis.	Nitrates	116-123	nitrate transporter 1.1	Arabidopsis thaliana	42-46
33374906-7	2020	Nitrate assimilation led to excessive ammonium accumulation in the shoot and lower nitrogen uptake, which exacerbated growth retardation of vha-a2 vha-a3.	Nitrates	0-7	vacuolar proton ATPase A2	Arabidopsis thaliana	140-146
33374906-7	2020	Nitrate assimilation led to excessive ammonium accumulation in the shoot and lower nitrogen uptake, which exacerbated growth retardation of vha-a2 vha-a3.	Nitrates	0-7	vacuolar proton ATPase A3	Arabidopsis thaliana	147-153
33183558-0	2020	Effect of a plant-based bioequivalent inorganic nitrate (NO3-) complex with vitamins, antioxidants and phytophenol rich food extracts in hypertensive individuals - A randomized, double-blind, placebo-controlled study.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
33183558-1	2020	BACKGROUND: This study assessed efficacy of plant based bioequivalent nitrate complex, consist of vitamins, natural antioxidants and phytophenol rich food extracts to elevate nitric oxide (NO) bioavailability as determined by saliva conversion of nitrate (NO3-) to nitrite (NO2-) a required step to produce NO, in relationship to lowering blood pressure (BP) in both men and women.	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	256-259
33169535-1	2020	Metallic Cu is a well-known electrocatalyst for nitrate reduction reaction (NO3 RR), but it suffers from relatively low activity, poor stability, and inducing nitrite accumulation during the long-term operation.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
33367898-4	2021	In Arabidopsis, the CIPK23 kinase has emerged as a major hub driving root responses to diverse environmental stresses including drought, salinity and nutrient imbalances such as potassium, nitrate and iron deficiencies as well as ammonium, magnesium and non-iron metals toxicities.	Nitrates	189-196	CBL-interacting protein kinase 23	Arabidopsis thaliana	20-26
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	89-96	L1 cell adhesion molecule	Homo sapiens	81-84
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	89-96	L1 cell adhesion molecule	Homo sapiens	81-84
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	89-96	L1 cell adhesion molecule	Homo sapiens	81-84
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	178-185	L1 cell adhesion molecule	Homo sapiens	50-53
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	178-185	L1 cell adhesion molecule	Homo sapiens	81-84
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	178-185	L1 cell adhesion molecule	Homo sapiens	81-84
32854085-6	2020	Good linearity (R2 > 0.99) ranges of 0.05 to 5 mg L-1 for nitrite and 1 to 50 mg L-1 for nitrate were obtained and detection limits of 50 mug L-1 for nitrite and 0.32 mg L-1 for nitrate were achieved.	Nitrates	178-185	L1 cell adhesion molecule	Homo sapiens	81-84
33254675-6	2020	Isotope and NO3-/Cl- analysis indicated that nitrate in the subsidence area water (SAW) was mainly derived from chemical fertilizer (NF) and soil organic nitrogen (NS), while nitrate in the mainstream of the Huihe River water (HRW) was mainly derived from manure/sewage (MS).	Nitrates	45-52	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
33048402-8	2020	We suggest that NID1 plays a crucial role as a transcription factor in optimizing plant growth by modulating the transcript abundance of the nitrate transceptor CHL1, leading to enhanced ABA accumulation in low-nitrate conditions.	Nitrates	141-148	nitrate transporter 1.1	Arabidopsis thaliana	161-165
33048402-8	2020	We suggest that NID1 plays a crucial role as a transcription factor in optimizing plant growth by modulating the transcript abundance of the nitrate transceptor CHL1, leading to enhanced ABA accumulation in low-nitrate conditions.	Nitrates	211-218	nitrate transporter 1.1	Arabidopsis thaliana	161-165
32907713-6	2020	We firstly found that NR activity was roughly positive-correlated with the root auxin level, and there is a crosstalk between nitrate signaling and auxin signaling.	Nitrates	126-133	nitrate reductase 1	Arabidopsis thaliana	22-24
32785584-1	2020	Nitrification is the microbial conversion of reduced forms of nitrogen (N) to nitrate (NO3-), and in fertilized soils it can lead to substantial N losses via NO3- leaching or nitrous oxide (N2O) production.	Nitrates	78-85	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
32933749-1	2020	NRT1.2 has been characterized as a low-affinity nitrate transporter and an abscisic acid (ABA) transporter in Arabidopsis.	Nitrates	48-55	nitrate transporter 1:2	Arabidopsis thaliana	0-6
33329669-2	2020	Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation.	Nitrates	114-121	cycling DOF factor 3	Arabidopsis thaliana	106-110
33329669-2	2020	Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation.	Nitrates	114-121	cycling DOF factor 3	Arabidopsis thaliana	147-151
33329669-2	2020	Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation.	Nitrates	174-181	cycling DOF factor 3	Arabidopsis thaliana	106-110
33329669-2	2020	Here, we describe the participation of Arabidopsis DNA binding with one finger (DOF) transcription factor CDF3 in nitrate responses and shows that CDF3 gene is induced under nitrate starvation.	Nitrates	174-181	cycling DOF factor 3	Arabidopsis thaliana	147-151
33329669-3	2020	Moreover, knockout cdf3 mutant plants exhibit nitrate-dependent lateral and primary root modifications, whereas CDF3 overexpression plants show increased biomass and enhanced root development under both nitrogen poor and rich conditions.	Nitrates	46-53	cycling DOF factor 3	Arabidopsis thaliana	19-23
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	cycling DOF factor 3	Arabidopsis thaliana	28-32
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	cycling DOF factor 3	Arabidopsis thaliana	52-56
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	glutamate synthase 2	Arabidopsis thaliana	165-185
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	nitrate transporter 2:1	Arabidopsis thaliana	233-237
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	nitrate transporter 2:1	Arabidopsis thaliana	241-245
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	nitrate transporter 2:1	Arabidopsis thaliana	241-245
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	protein-serine kinase 1	Arabidopsis thaliana	302-305
33329669-4	2020	Expression analyses of 35S::CDF3 lines reveled that CDF3 regulates the expression of an important set of nitrate responsive genes including, glutamine synthetase-1, glutamate synthase-2, nitrate reductase-1, and nitrate transporters NRT2.1, NRT2.4, and NRT2.5 as well as carbon assimilation genes like PK1 and PEPC1 in response to N availability.	Nitrates	105-112	Pyridoxal phosphate phosphatase-related protein	Arabidopsis thaliana	310-315
33329669-7	2020	These results highlight CDF3 as an important regulatory factor for the nitrate response, and its potential for improving N use efficiency in crops.	Nitrates	71-78	cycling DOF factor 3	Arabidopsis thaliana	24-28
32463943-0	2020	NRT2.1 C-terminus phosphorylation prevents root high affinity nitrate uptake activity in Arabidopsis thaliana.	Nitrates	62-69	nitrate transporter 2:1	Arabidopsis thaliana	0-6
33213070-11	2020	The patients that received Vit C had decreased levels of the nitrate and nitrite ratio (p < 0.01) and C-reactive protein levels (p = 0.04).	Nitrates	61-68	vitrin	Homo sapiens	27-30
33047961-4	2020	Deep nitrate storage varied from 43.6 to 1116.3 kg ha-1.	Nitrates	5-12	Rho GTPase activating protein 45	Homo sapiens	51-55
32781362-1	2020	Batch experiments were conducted to test the hypothesis that nitrate (NO3-) could be immobilized by biochar via adsorption of CaNO3+ to the negatively charged biochar surfaces.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
33188441-4	2020	Sublingual nitrate may provide additional benefit to rectal NSAIDs in preventing PEP.	Nitrates	11-18	prolyl endopeptidase	Homo sapiens	81-84
33188441-8	2020	There is emerging data that aggressive hydration with lactated Ringer"s and nitrates may further reduce PEP.	Nitrates	76-84	prolyl endopeptidase	Homo sapiens	104-107
32463943-1	2020	In Arabidopsis thaliana, NRT2.1 codes for a main component of the root nitrate high-affinity transport system.	Nitrates	71-78	nitrate transporter 2:1	Arabidopsis thaliana	25-29
32463943-2	2020	Previous studies revealed that post-translational regulation of NRT2.1 plays an important role in the control of root nitrate uptake and that one mechanism could correspond to NRT2.1 C-terminus processing.	Nitrates	118-125	nitrate transporter 2:1	Arabidopsis thaliana	64-70
32463943-2	2020	Previous studies revealed that post-translational regulation of NRT2.1 plays an important role in the control of root nitrate uptake and that one mechanism could correspond to NRT2.1 C-terminus processing.	Nitrates	118-125	nitrate transporter 2:1	Arabidopsis thaliana	64-68
32463943-7	2020	Finally, the relative level of serine 501 phosphorylation was found to be increased by ammonium nitrate in wild-type plants, leading to the inactivation of NRT2.1 and to a decrease in high affinity nitrate transport into roots.	Nitrates	96-103	nitrate transporter 2:1	Arabidopsis thaliana	156-162
32870279-0	2020	NRT1.1-centered nitrate signaling in plants.	Nitrates	16-23	nitrate transporter 1.1	Arabidopsis thaliana	0-6
33038483-15	2020	CONCLUSION: Bioactivation of NDOP involves functional XOR, and this new organic nitrate elicits vasorelaxation via NO-cGMP-PKG signaling and activation of KIR channels.	Nitrates	80-87	xanthine dehydrogenase	Rattus norvegicus	54-57
32870279-4	2020	NRT1.1 governs a wide range of responses to NO3-, from fast reprogramming of genome expression (the primary nitrate response) to longer-term developmental changes (effects on lateral root development).	Nitrates	108-115	nitrate transporter 1.1	Arabidopsis thaliana	0-4
33036562-1	2020	BACKGROUND: High-affinity nitrate transporter 2 (NRT2) genes have been implicated in nitrate absorption and remobilization under nitrogen (N) starvation stress in many plant species, yet little is known about this gene family respond to various stresses often occurs in the production of rapeseed (Brassica napus L.).	Nitrates	26-33	nitrate transporter 2:1	Arabidopsis thaliana	49-53
32854899-1	2020	Woodchip bioreactors are a practical, low-cost technology for reducing nitrate (NO3) loads discharged from agriculture.	Nitrates	71-78	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
32686596-2	2020	We recently demonstrated that nitrate deficiency induces root coiling on horizontal surface through nitrate transporter/sensor NRT1.1 and PIN2- and AUX-mediated polar auxin transport.	Nitrates	30-37	telomeric repeat binding factor 1	Homo sapiens	138-142
32870663-5	2020	Subsequent OH  oxidation and direct photolysis both decompose the organic nitrates (ONs, representing bulk functionalities of NACs and organonitrates) in the NO3 -aged wood tar aerosols, thus decreasing the particle absorption.	Nitrates	74-82	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
32686596-3	2020	Here, we show that nitrate deficiency or NRT1.1 loss-of-function induces differential distribution of PIN2 between the future concave and concave sides in root epidermal cells.	Nitrates	19-26	telomeric repeat binding factor 1	Homo sapiens	102-106
32146561-6	2020	Nitrate concentrations ranged between 2.43 and 96 mg L-1.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	53-56
32146561-7	2020	Results indicated that nitrate temporal trend was increased significantly in most of the wells, and the spatial trend of area percentage of nitrate class 3 (not permissible limit of more than 50 mg L-1) was positive.	Nitrates	140-147	immunoglobulin kappa variable 1-16	Homo sapiens	198-201
32377760-12	2020	Interestingly, PEDF levels were negatively correlated with plasma nitrite/nitrate levels and erectile function in DMED patients and STZ-induced diabetic rats.	Nitrates	74-81	serpin family F member 1	Homo sapiens	15-19
33005412-7	2020	Higher concentrations of IL-6, TNF-alpha, IL-1beta, nitrite ( NO 2 -  ) and nitrate ( NO 3 -  ) and a lower concentration of IL-10 were observed in CD163-deficient mice treated with LPS.	Nitrates	76-83	CD163 antigen	Mus musculus	148-153
32959807-2	2020	It has been hypothesized that synthesis of oxidized nitrogen in the form of nitrate (NO3-) and nitrite (NO2-), occurred in the prebiotic anoxic Hadean atmosphere.	Nitrates	76-83	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
32272331-1	2020	Sonochemical species such as nitrite (NO2-) and nitrate (NO3-) were detected in ultrapure aqueous medium with 28 kHz low frequency ultrasound (US) in the range of 200-1200 W output power.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
32878133-5	2020	In root tips, nitrate stimulated TaGS1;1, TaGS1;3, and TaGS2 expression in meristem, while NH4+ promoted tissue differentiation and TaGS1;2 expression in endodermis and vascular tissue.	Nitrates	14-21	glutamine synthetase leaf isozyme, chloroplastic	Triticum aestivum	55-60
32368787-8	2020	We hypothesized that maternal dietary nitrate administration would increase NO bioavailability to reduce systolic blood pressure (SBP), improve vascular function and increase fetal growth in pregnant endothelial NO synthase knockout (eNOS-/- ) mice, which exhibit hypertension, endothelial dysfunction and FGR.	Nitrates	38-45	nitric oxide synthase 3, endothelial cell	Mus musculus	234-238
32524996-0	2020	Dietary nitrate attenuated endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for NADPH oxidase.	Nitrates	8-15	apolipoprotein E	Mus musculus	74-90
32524996-4	2020	It was shown that dietary nitrate significantly attenuated aortic endothelial dysfunction and atherosclerosis in ApoE-/- mice.	Nitrates	26-33	apolipoprotein E	Mus musculus	113-117
32524996-5	2020	Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals.	Nitrates	42-49	apolipoprotein E	Mus musculus	163-167
32524996-5	2020	Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals.	Nitrates	42-49	xanthine dehydrogenase	Mus musculus	208-211
32524996-5	2020	Mechanistic studies revealed that dietary nitrate significantly improved plasma nitrate/nitrite, inhibited vascular NADPH oxidase activity and oxidative stress in ApoE-/- mice, while xanthine oxidoreductase (XOR) expression and activity was enhanced in ApoE-/- mice in comparison with wide type animals.	Nitrates	42-49	apolipoprotein E	Mus musculus	253-257
32524996-6	2020	These beneficial effects of nitrate in ApoE-/- mice were abolished by PTIO (NO scavenger) and significantly prevented by febuxostat (XOR inhibitor).	Nitrates	28-35	apolipoprotein E	Mus musculus	39-43
32524996-6	2020	These beneficial effects of nitrate in ApoE-/- mice were abolished by PTIO (NO scavenger) and significantly prevented by febuxostat (XOR inhibitor).	Nitrates	28-35	xanthine dehydrogenase	Mus musculus	133-136
32524996-9	2020	Altogether, boosting this nitrate-nitrite-NO signaling pathway resulted in the decreases of vascular NADPH oxidase-derived oxidative stress and endothelial dysfunction, and consequently protected ApoE-/- mice against atherosclerosis.	Nitrates	26-33	apolipoprotein E	Mus musculus	196-200
33124337-0	2020	[Quantification of Nitrate Sources to Groundwater in Karst Trough-valley Areas Based on Dual Stable Isotopes of delta15N-NO3- and delta18O-NO3- and the IsoSource Model].	Nitrates	19-26	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
33124337-0	2020	[Quantification of Nitrate Sources to Groundwater in Karst Trough-valley Areas Based on Dual Stable Isotopes of delta15N-NO3- and delta18O-NO3- and the IsoSource Model].	Nitrates	19-26	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
32759980-8	2020	These results suggest that nitrate ions are concentrated in the lacrimal glands by sialin and can be secreted into eye components via tears and then reduced to nitrite and NO, thereby being an important source of NO in the eye.	Nitrates	27-34	solute carrier family 17 member 5	Homo sapiens	83-89
32843498-6	2020	The mechanism underlying the effects of nitrate on HFD-induced obesity was investigated by the following: the NO3 --NO2 --NO pathway; endothelial NO synthase (eNOS) and cyclic guanosine monophosphate (cGMP) levels; gut microbiota via 16SRNA analysis.	Nitrates	40-47	NBL1, DAN family BMP antagonist	Mus musculus	110-113
32339643-5	2020	To this regard research has shown that in addition to the classical NO synthase (NOS) dependent pathway, nitrate from our diet can work as an alternative precursor for NO and other bioactive nitrogen oxide species via serial reductions of nitrate (i.e. nitrate-nitrite-NO pathway).	Nitrates	105-112	nitric oxide synthase 1	Homo sapiens	68-79
32843498-13	2020	CONCLUSIONS: Inorganic dietary nitrate alleviated HFD-induced obesity and ameliorated disrupted glucolipid metabolism via NO3 --NO2 --NO pathway activation and gut microbiome modulation.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Mus musculus	122-125
32732239-1	2020	Annotated genomes of Caballeronia strains SBC1 and SBC2 from acidic permafrost suggest a new species with a facultative lifestyle via oxygen and nitrate respiration.	Nitrates	145-152	solute carrier family 4 member 7	Homo sapiens	51-55
32449521-12	2020	Remarkably, dietary nitrate consumption attenuated and/or mitigated all these responses, including rendering mitochondria more coupled within BAT, and normalizing mitochondrial H2 O2 emission and insulin-mediated Akt-Thr308 phosphorylation within eWAT.	Nitrates	20-27	thymoma viral proto-oncogene 1	Mus musculus	213-216
32732978-1	2020	Alpha-lipoic acid (alpha-LA), a well-known antioxidant, was proved to active ALDH2 in nitrate tolerance and diabetic animal model.	Nitrates	86-93	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	77-82
32849729-4	2020	Contrarily, aseptically grown plants and axenic algal cells supplied with nitrate (NO3) are reported to emit N2O, indicating that it is produced inside plant cells by some unknown physiological phenomena.	Nitrates	74-81	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
31832669-0	2020	NRT1.1 in plants: functions beyond nitrate transporter.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	0-6
31832669-1	2020	Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	12-20
31832669-1	2020	Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	27-35
31832669-1	2020	Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport.	Nitrates	117-124	nitrate transporter 1.1	Arabidopsis thaliana	12-20
31832669-1	2020	Arabidopsis AtNRT1.1 (CHL1/AtNPF6.3) is the first identified nitrate transporter in plants and initially featured in nitrate uptake and transport.	Nitrates	117-124	nitrate transporter 1.1	Arabidopsis thaliana	27-35
31832669-2	2020	It is also found that AtNRT1.1 displays auxin transport activity and thus mediates nitrate-modulated root development, suggesting that it has transport capacities of multiple substrates.	Nitrates	83-90	nitrate transporter 1.1	Arabidopsis thaliana	22-30
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	72-79	nitrate transporter 1.1	Arabidopsis thaliana	30-38
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	72-79	nitrate transporter 1.1	Arabidopsis thaliana	203-211
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	109-116	nitrate transporter 1.1	Arabidopsis thaliana	30-38
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	109-116	nitrate transporter 1.1	Arabidopsis thaliana	203-211
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	109-116	nitrate transporter 1.1	Arabidopsis thaliana	30-38
31832669-3	2020	Subsequent work revealed that AtNRT1.1 can respond to the environmental nitrate fluctuation via altering its nitrate transport activity modulated by phosphorylation, leading to the critical finding that AtNRT1.1 actually acts as a transceptor for nitrate sensing.	Nitrates	109-116	nitrate transporter 1.1	Arabidopsis thaliana	203-211
31832669-4	2020	Recent studies further revealed how OsNRT1.1B, the functional homologue of AtNRT1.1 in rice, mediates the nitrate signal transduction from the plasma membrane to the nucleus, and how OsNRT1.1B integrates nitrate and phosphate signaling network.	Nitrates	106-113	nitrate transporter 1.1	Arabidopsis thaliana	75-83
31832669-4	2020	Recent studies further revealed how OsNRT1.1B, the functional homologue of AtNRT1.1 in rice, mediates the nitrate signal transduction from the plasma membrane to the nucleus, and how OsNRT1.1B integrates nitrate and phosphate signaling network.	Nitrates	204-211	nitrate transporter 1.1	Arabidopsis thaliana	75-83
32133500-5	2020	ZmTMM1 belongs to the AGL17-like MADS-box transcription factor family that contains orthologs of ANR1, a key regulator for root nitrate foraging in Arabidopsis.	Nitrates	128-135	AGAMOUS-like 17	Arabidopsis thaliana	22-27
32133500-5	2020	ZmTMM1 belongs to the AGL17-like MADS-box transcription factor family that contains orthologs of ANR1, a key regulator for root nitrate foraging in Arabidopsis.	Nitrates	128-135	AGAMOUS-like 44	Arabidopsis thaliana	97-101
32206788-2	2020	In plants, nitrogen (N) source for uptake and assimilation, mainly in the forms of nitrate (NO3-) and ammonium (NH4+) quantitatively dominates the anion and cation equilibrium and the pH balance in cells.	Nitrates	83-90	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
32428238-0	2020	The Arabidopsis NRT1.1 transceptor coordinately controls auxin biosynthesis and transport to regulate root branching in response to nitrate.	Nitrates	132-139	nitrate transporter 1.1	Arabidopsis thaliana	16-20
32428238-3	2020	In Arabidopsis, the NRT1.1 nitrate transceptor represses lateral root (LR) development at low nitrate availability by promoting auxin basipetal transport out of the LR primordia (LRPs).	Nitrates	27-34	nitrate transporter 1.1	Arabidopsis thaliana	20-26
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	72-79	nitrate transporter 1.1	Arabidopsis thaliana	5-11
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	72-79	tryptophan aminotransferase related 2	Arabidopsis thaliana	35-39
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	72-79	like AUX1 3	Arabidopsis thaliana	44-48
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	72-79	tryptophan aminotransferase related 2	Arabidopsis thaliana	132-136
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	72-79	like AUX1 3	Arabidopsis thaliana	141-145
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	nitrate transporter 1.1	Arabidopsis thaliana	5-11
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	tryptophan aminotransferase related 2	Arabidopsis thaliana	35-39
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	like AUX1 3	Arabidopsis thaliana	44-48
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	tryptophan aminotransferase related 2	Arabidopsis thaliana	132-136
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	like AUX1 3	Arabidopsis thaliana	141-145
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	nitrate transporter 1.1	Arabidopsis thaliana	5-11
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	tryptophan aminotransferase related 2	Arabidopsis thaliana	35-39
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	like AUX1 3	Arabidopsis thaliana	44-48
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	tryptophan aminotransferase related 2	Arabidopsis thaliana	132-136
32428238-7	2020	Both NRT1.1-mediated repression of TAR2 and LAX3 are suppressed at high nitrate availability, resulting in the nitrate induction of TAR2 and LAX3 expression that is required for optimal stimulation of LR development by nitrate.	Nitrates	111-118	like AUX1 3	Arabidopsis thaliana	141-145
32428238-8	2020	Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required for LRP development, and as a consequence that NRT1.1 plays a much more integrated role than previously anticipated in regulating the nitrate response of root system architecture.	Nitrates	269-276	nitrate transporter 1.1	Arabidopsis thaliana	42-48
32428238-8	2020	Altogether, our results indicate that the NRT1.1 transceptor coordinately controls several crucial auxin-associated processes required for LRP development, and as a consequence that NRT1.1 plays a much more integrated role than previously anticipated in regulating the nitrate response of root system architecture.	Nitrates	269-276	nitrate transporter 1.1	Arabidopsis thaliana	182-188
32663212-8	2020	Mean nitrate leaching rates for the years 2005-2017 were 9.4 kg N ha-1 yr-1, ranging from 0.04 to 53 kg N ha-1 yr-1.	Nitrates	5-12	solute carrier family 9 member B1	Homo sapiens	64-75
32765562-1	2020	As an important nitrogen source, nitrate (NO3 -) absorbed by plants is carried throughout the plant via short-distance distribution (cytoplasm to vacuole) and long-distance transportation (root to shoot), the two pathways that jointly regulate the content of NO3 - in plants.	Nitrates	33-40	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
32765562-1	2020	As an important nitrogen source, nitrate (NO3 -) absorbed by plants is carried throughout the plant via short-distance distribution (cytoplasm to vacuole) and long-distance transportation (root to shoot), the two pathways that jointly regulate the content of NO3 - in plants.	Nitrates	33-40	NBL1, DAN family BMP antagonist	Homo sapiens	259-262
32267563-1	2020	RATIONALE: The nitrogen isotopic ratio of nitrate (delta15 N-NO3 - value) is a critical parameter to understand nitrogen biogeochemical cycling in aquatic systems.	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
32646062-7	2020	Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNFalpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins.	Nitrates	14-21	tumor necrosis factor	Homo sapiens	110-118
32650602-9	2020	The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels.	Nitrates	145-152	inositol-3-phosphate synthase 1	Homo sapiens	66-70
32646062-7	2020	Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNFalpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins.	Nitrates	14-21	intercellular adhesion molecule 1	Homo sapiens	120-125
32583581-5	2020	An impressive removal capacity as high as 22 500 mg N g-1 CuPd ( 12 times superior to Fe-based catalysts), high nitrate conversion (>95%) and nitrogen selectivity (>95%) are achieved under a low initial concentration of nitrate (100 mg L-1 ) when using an optimized-NRR electrocatalyst (4CuPd@DCL-MCS/CNTs).	Nitrates	220-227	L1 cell adhesion molecule	Homo sapiens	236-239
32247143-1	2020	It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply.	Nitrates	47-54	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
32247143-1	2020	It is crucial to quantitatively track riverine nitrate (NO3-) sources and transformations in drinking water source watersheds for preventing current and future NO3- pollution, and ensuring a safe drinking water supply.	Nitrates	47-54	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
32583581-6	2020	Remarkably, nitrate conversion and nitrogen selectivity are both close to 100% in an ultralow concentration of 10 mg L-1 , meeting drinking water standard.	Nitrates	12-19	L1 cell adhesion molecule	Homo sapiens	117-120
32222508-1	2020	Woodchip bioreactors are viable low-cost nitrate (NO3-) removal applications for treating agricultural and aquaculture discharges.	Nitrates	41-48	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
32213401-5	2020	Among these, all membranes removed chloride but only NF97 and NF90 were able to remove nitrate in compliance with Chilean drinking water standard, showing rejections of 97% and 87%, respectively, in an optimum pressure range of 12-20 bar in which the NF90 produced 3.5 times more permeated water than NF97.	Nitrates	87-94	interleukin enhancer binding factor 3	Homo sapiens	62-66
32110844-3	2020	We thus developed a new method to measure delta15 N-NO3 - values in a saline sample with low nitrate concentration by improving the acetone method (the adapted method) and verified tits usability.	Nitrates	93-100	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
32574223-1	2020	PURPOSE: Nitrate (NO3-), through its conversion to nitrite (NO2-) and nitric oxide, has been shown to increase exercise tolerance in healthy younger adults and older diseased patients.	Nitrates	9-16	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
32612583-1	2020	Understanding the biogeochemical controls on the partitioning between nitrogen (N) removal through denitrification and anaerobic ammonium oxidation (anammox), and N recycling via dissimilatory nitrate (NO3 -) reduction to ammonium (DNRA) is crucial for constraining lacustrine N budgets.	Nitrates	193-200	NBL1, DAN family BMP antagonist	Homo sapiens	202-205
32537558-9	2020	Finally, we demonstrated that the AtGRXS8 protein can physically interact with the TGA1 and TGA4 transcription factors, which are central regulators of early transcriptional responses to nitrate in A. thaliana roots.	Nitrates	187-194	TGACG motif-binding factor 4	Arabidopsis thaliana	92-96
32537558-10	2020	Overall, these results suggest that AtGRXS8 acts to quench both transcriptional and developmental aspects of primary nitrate response, potentially by interfering with the activity of the TGA1 and TGA4 transcription factors.	Nitrates	117-124	bZIP transcription factor family protein	Arabidopsis thaliana	187-191
32537558-9	2020	Finally, we demonstrated that the AtGRXS8 protein can physically interact with the TGA1 and TGA4 transcription factors, which are central regulators of early transcriptional responses to nitrate in A. thaliana roots.	Nitrates	187-194	bZIP transcription factor family protein	Arabidopsis thaliana	83-87
32537558-10	2020	Overall, these results suggest that AtGRXS8 acts to quench both transcriptional and developmental aspects of primary nitrate response, potentially by interfering with the activity of the TGA1 and TGA4 transcription factors.	Nitrates	117-124	TGACG motif-binding factor 4	Arabidopsis thaliana	196-200
32523127-7	2020	Along with the transcriptional upregulation of NLPs, genotype IR-3-1-1, displayed highest expression of OsNRT1.1B gene, the closest rice homologue of nitrate transceptor AtNRT1.1 and plays major role in nitrate uptake, translocation and signaling in rice.	Nitrates	203-210	nitrate transporter 1.1	Arabidopsis thaliana	170-178
32523127-8	2020	The results showed that high NUE rice genotypes has both high Nitrogen uptake efficiency (NUpE) and Nitrogen utilization efficiency (NUtE), resulting from the effective and coordinated signal transduction network involving the rice homologue of nitrate transceptor OsNRT1.1B, the probable primary nitrate response (PNR) regulator OsNLP1 and the master response regulator OsNLP3, a homologue of AtNLP6/7.	Nitrates	245-252	Plant regulator RWP-RK family protein	Arabidopsis thaliana	394-402
32302589-5	2020	We identified the LGO gene, a CDK inhibitor, as a key cell cycle regulatory factor influencing ploidy and cell-size depending on external nitrate.	Nitrates	138-145	LOSS OF GIANT CELLS FROM ORGANS	Arabidopsis thaliana	18-21
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	32-39	nitrate transporter 1.1	Arabidopsis thaliana	98-104
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	32-39	nitrate transporter 2:1	Arabidopsis thaliana	109-113
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	41-45	nitrate transporter 1.1	Arabidopsis thaliana	98-104
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	41-45	nitrate transporter 2:1	Arabidopsis thaliana	109-113
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	77-84	nitrate transporter 1.1	Arabidopsis thaliana	98-104
32526869-2	2020	One of the essential nutrients, nitrate (NO3-), is sensed and transported by nitrate transporters NRT1.1 and NRT2.1 in the plants.	Nitrates	77-84	nitrate transporter 2:1	Arabidopsis thaliana	109-113
32526869-3	2020	Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes.	Nitrates	52-59	nitrate transporter 1.1	Arabidopsis thaliana	0-23
32526869-3	2020	Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes.	Nitrates	52-59	nitrate transporter 1.1	Arabidopsis thaliana	25-31
32526869-3	2020	Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes.	Nitrates	211-218	nitrate transporter 1.1	Arabidopsis thaliana	0-23
32526869-3	2020	Nitrate transporter 1.1 (NRT1.1) is a dual-affinity nitrate transporter phosphorylated at the T101 residue by calcineurin B-like interacting protein kinase (CIPKs); it also regulates the expression of other key nitrate assimilatory genes.	Nitrates	211-218	nitrate transporter 1.1	Arabidopsis thaliana	25-31
32302589-6	2020	Nitrate induces LGO gene expression as early as 3 days after germination in epidermal and mesophyll cell layers, which undergo endoreplication to increment DNA content and cell size.	Nitrates	0-7	LOSS OF GIANT CELLS FROM ORGANS	Arabidopsis thaliana	16-19
32124508-1	2020	The balance between nitrate respiration pathways, denitrification and dissimilatory nitrate (NO3 - ) reduction to ammonium (DNRA), determines whether bioavailable nitrogen is removed as N2 gas or recycled as ammonium.	Nitrates	84-91	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
32514747-5	2020	The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters.	Nitrates	269-276	serine/threonine-protein kinase SAPK2	Oryza sativa Japonica Group	121-126
32514747-5	2020	The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters.	Nitrates	330-337	serine/threonine-protein kinase SAPK2	Oryza sativa Japonica Group	121-126
32514747-5	2020	The examination of rice seedling growth and development under nutrient-deprived conditions (-N, -K, and - P) proved that SAPK2 can significantly affect rice seedling growth and root development in hydroponic cultures lacking N and K. Moreover, the NO3- influx rate and nitrate concentration analysis indicated that SAPK2 promotes nitrate uptake and assimilation by regulating nitrate-related transporters.	Nitrates	330-337	serine/threonine-protein kinase SAPK2	Oryza sativa Japonica Group	121-126
32582237-0	2020	NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport.	Nitrates	16-23	nitrate transporter 1.1	Arabidopsis thaliana	0-6
32582237-0	2020	NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport.	Nitrates	16-23	Auxin efflux carrier family protein	Arabidopsis thaliana	62-66
32582237-0	2020	NRT1.1-Mediated Nitrate Suppression of Root Coiling Relies on PIN2- and AUX1-Mediated Auxin Transport.	Nitrates	16-23	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	72-76
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	133-144
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	146-150
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	156-173
32582237-6	2020	Nitrate deficiency caused root coiling on horizontal plates, which is inhibited by an auxin transport inhibitor, and by mutations in PIN-FORMED2 (PIN2) and AUXIN RESISTANT 1 (AUX1).	Nitrates	0-7	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	175-179
32582237-7	2020	We further show that suppression of ARG by nitrate is mediated by the nitrate transporter/sensor NRT1.1.	Nitrates	43-50	nitrate transporter 1.1	Arabidopsis thaliana	97-103
32582237-8	2020	In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG.	Nitrates	81-88	Auxin efflux carrier family protein	Arabidopsis thaliana	13-17
32582237-8	2020	In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG.	Nitrates	81-88	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	23-27
32582237-8	2020	In addition, PIN2- and AUX1-mediated auxin transports are epistatic to NRT1.1 in nitrate deficiency-induced ARG.	Nitrates	81-88	nitrate transporter 1.1	Arabidopsis thaliana	71-77
32157271-0	2020	Arabidopsis chloroplast J protein DJC75/CRRJ mediates nitrate-promoted seed germination in the dark.	Nitrates	54-61	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	34-39
32157271-0	2020	Arabidopsis chloroplast J protein DJC75/CRRJ mediates nitrate-promoted seed germination in the dark.	Nitrates	54-61	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	40-44
32157271-2	2020	Here, we show that a plastid J-domain protein DJC75/CRRJ in Arabidopsis (Arabidopsis thaliana) is important for nitrate-promoted seed germination in the dark.	Nitrates	112-119	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	46-51
32157271-2	2020	Here, we show that a plastid J-domain protein DJC75/CRRJ in Arabidopsis (Arabidopsis thaliana) is important for nitrate-promoted seed germination in the dark.	Nitrates	112-119	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	52-56
32157271-4	2020	The seed germination rate of mutants defective in DJC75 was determined in the presence of nitrate when light cues for seed germination were eliminated by the treatment of imbibed seeds with a pulse of far-red light to inactivate phyB, or by assaying germination in the dark with seeds harboring the phyB mutation.	Nitrates	90-97	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	50-55
32157271-7	2020	Mutants defective in DJC75 showed seed germination defects in the presence of nitrate when light cues for seed germination were eliminated.	Nitrates	78-85	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	21-26
32157271-9	2020	Upregulation of GA biosynthetic gene GA3ox1 expression by nitrate in imbibed phyB mutant seeds was diminished when DJC75 was knocked-out.	Nitrates	58-65	gibberellin 3-oxidase 1	Arabidopsis thaliana	37-43
32157271-9	2020	Upregulation of GA biosynthetic gene GA3ox1 expression by nitrate in imbibed phyB mutant seeds was diminished when DJC75 was knocked-out.	Nitrates	58-65	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	115-120
32157271-10	2020	CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination.	Nitrates	76-83	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	60-65
32157271-10	2020	CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination.	Nitrates	76-83	gibberellin 3-oxidase 1	Arabidopsis thaliana	178-184
32157271-10	2020	CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination.	Nitrates	76-83	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	223-228
32157271-10	2020	CONCLUSIONS: Our data suggest that plastid J-domain protein DJC75 regulates nitrate-promoted seed germination in the dark by upregulation of expression of GA , biosynthetic gene GA3ox1 through an unknown mechanism and that DJC75 may work in concert with chloroplast Hsp70s to regulate nitrate-promoted seed germination.	Nitrates	285-292	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	60-65
32157271-11	2020	DJC75 is the first pathway component identified for nitrate-promoted seed germination in the dark.	Nitrates	52-59	Chaperone DnaJ-domain superfamily protein	Arabidopsis thaliana	0-5
31342638-0	2020	Phosphorylation at Ser28 stabilizes the Arabidopsis nitrate transporter NRT2.1 in response to nitrate limitation.	Nitrates	52-59	nitrate transporter 2:1	Arabidopsis thaliana	72-78
32300065-6	2020	The lower arterial pressure and enhanced natriuresis during high salt loading in Pkd1 knockout mice were associated with lower urinary nitrite/nitrate excretion and markedly increased urinary PGE2 excretion, whereas GFR, plasma renin concentration, and urinary endothelin-1 excretion were similar between knockout and control mice.	Nitrates	143-150	polycystin 1, transient receptor potential channel interacting	Mus musculus	81-85
31342638-9	2020	These results demonstrate that phosphorylation at Ser28 is crucial for NRT2.1 protein stabilization and accumulation in response to nitrate limitation.	Nitrates	132-139	nitrate transporter 2:1	Arabidopsis thaliana	71-77
31342638-3	2020	Nitrate transporter 2.1 (NRT2.1) is the major component of the root high-affinity nitrate transport system in Arabidopsis thaliana.	Nitrates	82-89	nitrate transporter 2:1	Arabidopsis thaliana	0-23
31342638-3	2020	Nitrate transporter 2.1 (NRT2.1) is the major component of the root high-affinity nitrate transport system in Arabidopsis thaliana.	Nitrates	82-89	nitrate transporter 2:1	Arabidopsis thaliana	25-29
31342638-6	2020	When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1.	Nitrates	35-42	nitrate transporter 2:1	Arabidopsis thaliana	89-95
31342638-6	2020	When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1.	Nitrates	35-42	nitrate transporter 2:1	Arabidopsis thaliana	152-158
31342638-6	2020	When seedlings were transferred to nitrate-limited conditions, the apparent half-life of NRT2.1 in roots increased from 3 to 9 h. This stabilization of NRT2.1 protein occurred rapidly, even prior to the transcriptional stimulation of NRT2.1.	Nitrates	35-42	nitrate transporter 2:1	Arabidopsis thaliana	152-158
32317363-1	2020	The interaction of C-Terminally Encoded Peptides (CEPs) with CEP RECEPTOR 1 (CEPR1) controls root growth and development, as well as nitrate uptake, but has no known role in determining yield.	Nitrates	133-140	Leucine-rich repeat transmembrane protein kinase family protein	Arabidopsis thaliana	77-82
32801436-11	2020	Conclusion: EECP-therapy decreased the expression of TLR2 on peripheral monocytes in patients with chronic stable refractory angina which yield improvement in the quality of patients" life by decreasing the frequency of angina episodes, decreasing the Short-acting nitrate use and change the exercise tolerance and distance.	Nitrates	265-272	toll like receptor 2	Homo sapiens	53-57
32466182-0	2020	Novel Barbiturate-Nitrate Compounds Inhibit the Upregulation of Matrix Metalloproteinase-9 Gene Expression in Intestinal Inflammation through a cGMP-Mediated Pathway.	Nitrates	18-25	matrix metallopeptidase 9	Homo sapiens	64-90
32550602-3	2020	Few reports described the simultaneous formation of ammonia (NH4 +) and nitrate (NO3 -) by a photocatalytic reaction and the related mechanism.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
32528483-1	2020	Chloride (Cl-) has traditionally been considered harmful to agriculture because of its toxic effects in saline soils and its antagonistic interaction with nitrate (NO3 -), which impairs NO3 - nutrition.	Nitrates	155-162	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
32528483-1	2020	Chloride (Cl-) has traditionally been considered harmful to agriculture because of its toxic effects in saline soils and its antagonistic interaction with nitrate (NO3 -), which impairs NO3 - nutrition.	Nitrates	155-162	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
32466182-2	2020	Barbiturate nitrate hybrid compounds have been designed to inhibit MMP secretion and enzyme activity.	Nitrates	12-19	matrix metallopeptidase 1	Homo sapiens	67-70
31231758-3	2020	We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3-   nitrite (NO2 )   NO enterosalivary pathway, could increase muscle contractile function in older subjects.	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
31231758-3	2020	We therefore hypothesized that dietary nitrate (NO3-), a source of NO via the NO3-   nitrite (NO2 )   NO enterosalivary pathway, could increase muscle contractile function in older subjects.	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
32105927-1	2020	Accurate identification of nitrate (NO3-) sources is critical to address the issue of groundwater pollution.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
31811920-10	2020	Moreover, microbiota analysis revealed that nitrate could partially decrease the enriched metabolic pathways (p53 signaling pathway and colorectal cancer pathway) compared with that in the DSS and DSS + NaCl groups.	Nitrates	44-51	tumor protein p53	Homo sapiens	110-113
32250790-1	2020	Stream and riparian zone networks embedded in agricultural landscapes provide a potential intervention point to ameliorate the negative effects of agricultural runoff by reducing transport of nitrate (NO3-) and suspended sediments (SS) downstream.	Nitrates	192-199	NBL1, DAN family BMP antagonist	Homo sapiens	201-204
32092511-1	2020	Sediment denitrification (DEN), anaerobic ammonium oxidation (Anammox), and dissimilatory nitrate reduction to ammonium (DNRA) are three important nitrate (NO3-) reduction pathways in aquatic ecosystems.	Nitrates	90-97	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
32092511-1	2020	Sediment denitrification (DEN), anaerobic ammonium oxidation (Anammox), and dissimilatory nitrate reduction to ammonium (DNRA) are three important nitrate (NO3-) reduction pathways in aquatic ecosystems.	Nitrates	147-154	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
32250815-2	2020	This could lead to increased nitrate (NO3-) leaching when water scarcity affects the N-uptake capacity of trees and increases soil N availability due to early leaf senescence and higher litter input.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
32086288-7	2020	Mechanistically, we determine that nitrate induces these phenotypic changes in primary adipocytes through the xanthine oxidoreductase catalysed reduction of nitrate to nitric oxide and independently of Peroxisome Proliferator-Activated Receptor alpha.	Nitrates	35-42	xanthine dehydrogenase	Rattus norvegicus	110-133
32062279-7	2020	The relationships between mass fractions of SO42- and NO3- in those ranges of different alkaline metal ion content also suggested that alkaline metal ions participate in the competing neutralization reaction of sulfate and nitrate.	Nitrates	223-230	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
32070893-1	2020	Nitrate (NO3-) contamination in groundwater is an environmental problem worldwide.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32070893-9	2020	Nitrate in groundwater in industrial areas has different pattern of the proportional contribution, in which groundwater NO3- is largely influenced by sewage discharge and atmospheric precipitation.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
32393171-10	2020	Notably, we found a transcription factor ZmNLP6, a homolog of AtNLP7-a well-known regulator for N-response and root growth-generates several isoforms varied in capacities of activating downstream targets specifically after nitrate supply.	Nitrates	223-230	NIN like protein 7	Arabidopsis thaliana	62-68
32086288-7	2020	Mechanistically, we determine that nitrate induces these phenotypic changes in primary adipocytes through the xanthine oxidoreductase catalysed reduction of nitrate to nitric oxide and independently of Peroxisome Proliferator-Activated Receptor alpha.	Nitrates	157-164	xanthine dehydrogenase	Rattus norvegicus	110-133
31506874-8	2020	Other trace elements are aluminum-30%, arsenic-10%, and nitrate (NO3)-10%, and they are examples of elements which have above MAC for drinking water.	Nitrates	56-63	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
32067475-1	2020	Nitrate (NO3-) sources and discharge were investigated using isotope and hydrochemical analyses in three river catchments draining Lake Victoria basin, Kenya.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32316351-1	2020	In this paper, an all-solid-state nitrate doped polypyrrole (PPy(NO3-) ion-selective electrode (ISE) was prepared with a nanohybrid composite film of gold nanoparticles (AuNPs) and electrochemically reduced graphene oxide (ERGO).	Nitrates	34-41	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
32172966-1	2020	Excessive nitrate (NO3-) is among the most problematic surface water and groundwater pollutants.	Nitrates	10-17	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
31811679-0	2020	Nitrate-inducible NIGT1 Proteins Modulate Phosphate Uptake and Starvation Signaling via Transcriptional Regulation of SPX Genes.	Nitrates	0-7	spexin hormone	Homo sapiens	118-121
31811679-6	2020	Furthermore, protoplast-based transient expression assay and chromatin immunoprecipitation assay demonstrate that NIGT1 GARP-type transcriptional repressors, which are encoded by nitrate-inducible genes, directly bind to and repress the promoters of genes encoding SPX proteins.	Nitrates	179-186	cyclic nucleotide gated channel subunit beta 1	Homo sapiens	120-124
31811679-6	2020	Furthermore, protoplast-based transient expression assay and chromatin immunoprecipitation assay demonstrate that NIGT1 GARP-type transcriptional repressors, which are encoded by nitrate-inducible genes, directly bind to and repress the promoters of genes encoding SPX proteins.	Nitrates	179-186	spexin hormone	Homo sapiens	265-268
31811679-7	2020	Consistent with the role of SPX proteins in the suppression of the PHR1 transcriptional activator, the master regulator for phosphate starvation responses, nitrate-dependent enhancement of phosphate starvation responses, such as accumulation of anthocyanin and promotion of root hair growth and phosphate uptake, was less evident in the nigt1.1-nigt1.4 quadruple mutant.	Nitrates	156-163	spexin hormone	Homo sapiens	28-31
31811679-7	2020	Consistent with the role of SPX proteins in the suppression of the PHR1 transcriptional activator, the master regulator for phosphate starvation responses, nitrate-dependent enhancement of phosphate starvation responses, such as accumulation of anthocyanin and promotion of root hair growth and phosphate uptake, was less evident in the nigt1.1-nigt1.4 quadruple mutant.	Nitrates	156-163	pleckstrin homology domain containing B1	Homo sapiens	67-71
32097807-2	2020	After 140 days" enrichment, the nitrate removal rate increased significantly from 3 to 4 mg-N L-1 d-1 to 22.09 +- 1.21 mg-N L-1 d-1 and the indicator, mol CH4 consumed/mol reduced NO3--N (C/N ratio), decreased to 1.79 which was very close to the theoretical minimum value (1.27-1.39).	Nitrates	32-39	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
31981873-2	2020	The oxygen-17 excess of nitrate (Delta17O(NO3-)) can be used to reveal the relative importance of nitrate formation pathways and get more insight into reactive nitrogen chemistry.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
31981873-2	2020	The oxygen-17 excess of nitrate (Delta17O(NO3-)) can be used to reveal the relative importance of nitrate formation pathways and get more insight into reactive nitrogen chemistry.	Nitrates	98-105	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
31981873-6	2020	Delta17O(NO3-)-constrained estimates suggest that the conversion of NOX to nitrate is dominated by NO2 + OH and/or NO2 + H2O, with the mean possible contribution of 55-77% in total and even higher (84-92%) in summer.	Nitrates	75-82	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32608665-4	2020	The results show that approximately 7.83% of rivers in China exceeded the Chinese drinking water standard for nitrate (45 mg L-1).	Nitrates	110-117	L1 cell adhesion molecule	Homo sapiens	125-128
32064956-4	2020	Also, prolactin markedly reduces the increased levels of the neurotransmitters (gamma-aminobutyric acid and glutamate), cerebral calcium and nitrate in different brain compartments of ischemic rats.Conclusion: Prolactin is able to ameliorate ischemia-reperfusion injury in rat brain and might be a potent candidate for further neuro-therapeutics development.	Nitrates	141-148	prolactin	Rattus norvegicus	6-15
32007629-6	2020	RESULTS: There was a strong positive correlation between urinary nitrate clearance and eGFR, (Spearman R = 0.7665, p < 0.0001) with a moderate negative correlation between plasma nitrate concentration and CKD-EPI eGFR, (Spearman"s R = -0.37, p = 0.012).	Nitrates	65-72	epidermal growth factor receptor	Homo sapiens	87-91
32126767-4	2020	In contrast to the previous view of weak winter photochemistry, we show that the O3 and OH productions are sufficiently high in winter to facilitate fast gas-phase and heterogeneous conversion of NOX to nitrate over the NCP.	Nitrates	203-210	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	81-90
32126767-5	2020	Increasing O3 and OH productions from higher precursor levels and fast ROX cycling accelerate the nitrate generation during heavy pollution.	Nitrates	98-105	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	11-20
32126767-5	2020	Increasing O3 and OH productions from higher precursor levels and fast ROX cycling accelerate the nitrate generation during heavy pollution.	Nitrates	98-105	MAX network transcriptional repressor	Homo sapiens	71-74
32120180-7	2020	In nitrate-taking patients, serum complement C1q had a negative association with Gensini score (r=-0.275, P = 0.001), and in non-smokers, there was also a negative correlation (beta=-0.159, P = 0.036).	Nitrates	3-10	complement C1q A chain	Homo sapiens	45-48
32007629-7	2020	There was a trend between fractional excretion of nitrate and CKD-EPI eGFR (ml/min/1.73 m2) Spearman"s R 0.27, p = 0.07 though this did not reach statistical significance.	Nitrates	50-57	epidermal growth factor receptor	Homo sapiens	70-74
32148171-7	2021	The treated effluent that received 20% of leachate showed 2.7 mg L-1 ammonia and 1.1 mg L-1 nitrate.	Nitrates	92-99	L1 cell adhesion molecule	Homo sapiens	88-91
31793100-3	2020	Predominantly expressed and accumulated in roots and vascular tissues, ZmNLP5 was shown to rapidly respond to nitrate treatment.	Nitrates	110-117	Protein RKD4	Zea mays	71-77
31793100-4	2020	Under limited N supply, compared with that of wild-type (WT) seedlings, the zmnlp5 mutant seedlings accumulated less nitrate and nitrite in the root tissues and ammonium in the shoot tissues.	Nitrates	117-124	Protein RKD4	Zea mays	76-82
31793100-6	2020	Furthermore, the mutants carrying the transgenic ZmNLP5 cDNA fragment significantly increased the nitrate content in the root tissues compared with that of the zmnlp5 mutants.	Nitrates	98-105	Protein RKD4	Zea mays	49-55
31793100-8	2020	We further show that ZmNLP5 directly regulates the expression of nitrite reductase 1.1 (ZmNIR1.1) by binding to the nitrate-responsive cis-element (NRE) at the 5" UTR of the gene.	Nitrates	116-123	Protein RKD4	Zea mays	21-27
32118414-1	2020	Electrochemical conversion of nitrate (NO3-) into ammonia (NH3) recycles nitrogen and offers a route to the production of NH3, which is more valuable than dinitrogen gas.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
32187974-6	2020	Our results suggest that nitrate dual-isotope was very useful for tracing the main NO3- sources in the condition of the sufficient ammonium, and runoff exerted an important impact on the shift in NO3- sources between both the local source and the source from the upper river basin during the two seasons in this monsoon-controlled bay.	Nitrates	25-32	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
31929050-4	2020	The ratio of the first-order rate coefficient of fumarate to nitrate (k1,fum/k1,NO3) was obtained to estimate the amount and frequency of fumarate injection for the effective design of WDB.	Nitrates	61-68	keratin 1	Homo sapiens	77-83
31951900-9	2020	Only NIA1 was detected in roots and its expression, together with NR activity and nitrates levels, was the highest in N medium devoid of Cd.	Nitrates	82-90	nitrate reductase 1	Arabidopsis thaliana	5-9
32608629-5	2020	The total annual runoff in the Shipanqiu small watershed was 8.02x104 m3, and the annual total nitrogen loss flux was 5.04 kg hm-2, of which nitrate nitrogen (2.54 kg hm-2) was the main part.	Nitrates	141-148	cholinergic receptor muscarinic 2	Homo sapiens	167-171
31875569-1	2020	Nitrate (NO3-) affected perchlorate (ClO4-) reduction in a membrane batch biofilm reactor (MBBR), even though the electron donor, CH4, was available well in excess of its demand.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31875569-7	2020	Analysis based on Density Functional Theory (DFT) suggests that bacteria able to utilize both acceptors, preferred NO3- over ClO4- due to nitrate reduction having lower energy barriers for proton and electron transfers.	Nitrates	138-145	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
31972916-9	2020	Ratios of [NO3-]/[SO42-] and [NH4+]/[SO42-] in the four stages declared that nitrate formation preferred heterogeneous conversions.	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
32090224-2	2020	Pulse radiolysis measurements are performed to find the rate constant of the reaction between NO3  radicals and U(iv) in highly concentrated nitrate solution.	Nitrates	141-148	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
32211003-3	2020	Nitrate (NO3 -) is often the primary nitrogen source, but it also serves as a signaling molecule to the plant.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
32100606-5	2020	Nitrate signaling has recently been shown to use AON components such as CLE-RS2 and HAR1 to control nodule number.	Nitrates	0-7	CM0216.560.nc	Lotus japonicus	84-88
32179400-1	2020	Mixotrophic nitrate removal in wastewater from coal pyrolysis was achieved in microbial electrolysis cell with iron anode (iron-MEC).	Nitrates	12-19	C-C motif chemokine ligand 28	Homo sapiens	128-131
32100606-9	2020	Hence, while the nitrate-induced control mechanism of nodule number uses AON components, an unknown pathway specific to nitrate may exist downstream of HAR1, acting in parallel with the HAR1> TML pathway.	Nitrates	17-24	CM0216.560.nc	Lotus japonicus	186-190
32100606-9	2020	Hence, while the nitrate-induced control mechanism of nodule number uses AON components, an unknown pathway specific to nitrate may exist downstream of HAR1, acting in parallel with the HAR1> TML pathway.	Nitrates	120-127	CM0216.560.nc	Lotus japonicus	152-156
31884326-9	2020	From these results, it can be concluded that NRT1.1 modulates Zn accumulation in plants via a nitrate-dependent pathway.	Nitrates	94-101	nitrate transporter 1.1	Arabidopsis thaliana	45-51
31654807-5	2020	Excessive residues (>360 kg/hm2) resulted in obvious phenomenon of preferential flow, which increased the wetting distance, wetted volume, and water content in the lower part of the wetted volume and the concentration of nitrate at the boundary of the wetted volume.	Nitrates	221-228	cholinergic receptor muscarinic 2	Homo sapiens	28-31
32129362-8	2020	Nitrate administration in the DN group also decreased miR-34b (p < 0.001) and p53 mRNA (p < 0.001) expression, and increased serum insulin and NOx levels compared to the untreated diabetic rats.	Nitrates	0-7	microRNA 34b	Rattus norvegicus	54-61
32129362-8	2020	Nitrate administration in the DN group also decreased miR-34b (p < 0.001) and p53 mRNA (p < 0.001) expression, and increased serum insulin and NOx levels compared to the untreated diabetic rats.	Nitrates	0-7	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	78-81
32129362-9	2020	CONCLUSIONS: Chronic nitrate supplementation in streptozotocin-induced diabetic rats improved fertility parameters, which may be associated with increased miR-34b and decreased p53 mRNA.	Nitrates	21-28	microRNA 34b	Rattus norvegicus	155-162
32129362-9	2020	CONCLUSIONS: Chronic nitrate supplementation in streptozotocin-induced diabetic rats improved fertility parameters, which may be associated with increased miR-34b and decreased p53 mRNA.	Nitrates	21-28	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	177-180
31868639-5	2020	This is due to the presence of organic and inorganic matter (bicarbonates, nitrates, and chlorides) in surface and tap water, that react with the radicals generated, which reduces the availability of radical species, generating competitive kinetics.	Nitrates	75-83	nuclear RNA export factor 1	Homo sapiens	115-118
32440316-9	2020	In the nitrate tolerance group, the level of activated eNOS decreased and the level of deactivated eNOS increased.	Nitrates	7-14	nitric oxide synthase 3	Homo sapiens	55-59
32440316-9	2020	In the nitrate tolerance group, the level of activated eNOS decreased and the level of deactivated eNOS increased.	Nitrates	7-14	nitric oxide synthase 3	Homo sapiens	99-103
31972252-4	2020	These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate.	Nitrates	28-35	xanthine dehydrogenase	Mus musculus	144-167
31915951-5	2020	Quantitative reverse transcription polymerase chain reaction analysis revealed a high level of expression of the high affinity nitrate transporter gene, NRT2.1 in A. thaliana treated with Bs L1.	Nitrates	127-134	nitrate transporter 2:1	Arabidopsis thaliana	153-157
31972252-4	2020	These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate.	Nitrates	243-250	xanthine dehydrogenase	Mus musculus	144-167
31810032-1	2020	Nitrate (NO3-) fate estimates in turbulent karst pathways are lacking due, in part, to the difficulty of accessing remote subsurface environments.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31937682-3	2020	Here, based on recently released whole-genome information for bread wheat, the high-affinity nitrate transporter 2 (NRT2) and the nitrate-assimilation-related (NAR) gene family are characterized.	Nitrates	93-100	high-affinity nitrate transporter 2.1	Triticum aestivum	116-120
31937682-4	2020	We show that ABA-GE deconjugation is stimulated in bread wheat roots by nitrate resupply following nitrate withdrawal, leading to enhanced root-tissue ABA accumulation, and that this enhancement, in turn, affects the expression of root-type NRT2/NAR genes.	Nitrates	72-79	high-affinity nitrate transporter 2.1	Triticum aestivum	241-245
31937682-4	2020	We show that ABA-GE deconjugation is stimulated in bread wheat roots by nitrate resupply following nitrate withdrawal, leading to enhanced root-tissue ABA accumulation, and that this enhancement, in turn, affects the expression of root-type NRT2/NAR genes.	Nitrates	99-106	high-affinity nitrate transporter 2.1	Triticum aestivum	241-245
32106816-7	2020	High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R.	Nitrates	10-17	angiotensinogen	Rattus norvegicus	102-116
31937682-6	2020	Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops.	Nitrates	97-104	high-affinity nitrate transporter 2.1	Triticum aestivum	228-232
31937682-6	2020	Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops.	Nitrates	181-188	high-affinity nitrate transporter 2.1	Triticum aestivum	228-232
31937682-6	2020	Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops.	Nitrates	181-188	high-affinity nitrate transporter 2.1	Triticum aestivum	228-232
31937682-6	2020	Building on previous evidence establishing ABA involvement in the developmental response to high-nitrate stress, our study suggests that ABA also contributes to the optimisation of nitrate uptake by regulating the expression of NRT2/NAR genes under limited nitrate supply, offering a new target for improvement of nitrate absorption in crops.	Nitrates	181-188	high-affinity nitrate transporter 2.1	Triticum aestivum	228-232
32106816-7	2020	High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R.	Nitrates	10-17	adenosine A2a receptor	Rattus norvegicus	193-201
32106816-7	2020	High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R.	Nitrates	10-17	angiotensin II receptor, type 2	Rattus norvegicus	207-211
32106816-7	2020	High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R.	Nitrates	10-17	angiotensin II receptor, type 1a	Rattus norvegicus	165-169
32106816-7	2020	High-dose nitrate or olmesartan alone, and especially in combination, decreased the levels of PRA and angiotensin II and downregulated the CHF-induced expression of AT1R, alpha1A-, beta1-, and beta2-AR, and AT2R.	Nitrates	10-17	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	181-186
32009064-0	2020	East Asians Variant Mitochondrial Aldehyde Dehydrogenase 2 Genotype Exacerbates Nitrate Tolerance in Patients With Coronary Spastic Angina.	Nitrates	80-87	aldehyde dehydrogenase 2 family member	Homo sapiens	34-58
31914408-5	2020	Here, using genetic code expansion to site-specifically nitrate calmodulin at its two tyrosine residues, we assessed the effects of these alterations on calcium binding by calmodulin and on binding and activation of eNOS.	Nitrates	56-63	calmodulin 1	Homo sapiens	64-74
31699333-0	2020	Feedforward Control of Plant Nitrate Transporter NRT1.1 Biphasic Adaptive Activity.	Nitrates	29-36	immunoglobulin superfamily member 9	Homo sapiens	49-53
31699333-2	2020	Recent discovery of a plasma membrane nitrate transceptor protein NRT1.1-a transporter cum sensor-provides a clue on this toggling mechanism.	Nitrates	38-45	immunoglobulin superfamily member 9	Homo sapiens	66-70
31699333-4	2020	Here, we illustrate adaptive responses and regulation of NRT1.1-mediated nitrate signaling in a wide range of extracellular nitrate concentrations.	Nitrates	73-80	immunoglobulin superfamily member 9	Homo sapiens	57-61
31699333-4	2020	Here, we illustrate adaptive responses and regulation of NRT1.1-mediated nitrate signaling in a wide range of extracellular nitrate concentrations.	Nitrates	124-131	immunoglobulin superfamily member 9	Homo sapiens	57-61
31699333-5	2020	The results show that the homodimeric structure of NRT1.1 and its dimeric switch play an important role in eliciting specific cytosolic calcium waves sensed by the calcineurin-B-like calcium sensor CBL9, which activates the kinase CIPK23, in low nitrate concentration that is, however, impeded in high nitrate concentration.	Nitrates	246-253	immunoglobulin superfamily member 9	Homo sapiens	51-55
31699333-5	2020	The results show that the homodimeric structure of NRT1.1 and its dimeric switch play an important role in eliciting specific cytosolic calcium waves sensed by the calcineurin-B-like calcium sensor CBL9, which activates the kinase CIPK23, in low nitrate concentration that is, however, impeded in high nitrate concentration.	Nitrates	302-309	immunoglobulin superfamily member 9	Homo sapiens	51-55
31699333-6	2020	Nitrate binding at the high-affinity unit initiates NRT1.1 dimer decoupling and priming of the Thr101 site for phosphorylation by CIPK23.	Nitrates	0-7	immunoglobulin superfamily member 9	Homo sapiens	52-56
31699333-7	2020	This phosphorylation stabilizes the NRT1.1 monomeric state, acting as a high-affinity nitrate transceptor.	Nitrates	86-93	immunoglobulin superfamily member 9	Homo sapiens	36-40
31699333-8	2020	However, nitrate binding in both monomers, retaining the unmodified NRT1.1 state through dimerization, attenuates CIPK23 activity and thereby maintains the low-affinity mode of nitrate signaling and transport.	Nitrates	9-16	immunoglobulin superfamily member 9	Homo sapiens	68-72
31699333-9	2020	This phosphorylation-led modulation of NRT1.1 activity shows bistable behavior controlled by an incoherent feedforward loop, which integrates nitrate-induced positive and negative regulatory effects on CIPK23.	Nitrates	142-149	immunoglobulin superfamily member 9	Homo sapiens	39-43
31837546-1	2020	This study determined the spatial and temporal changes in natural abundance of stable isotopes (delta13C, delta15N, and delta18O) with regard to nitrate (NO3-) and retained sludge in a nitrifying bioreactor.	Nitrates	145-152	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
32117389-8	2020	An RNA sequencing analysis revealed that ZmCHB101 regulates the expression of genes involved in nitrate transport, including ZmNRT2.1 and ZmNRT2.2.	Nitrates	96-103	nitrate transport 2	Zea mays	125-133
31896222-5	2020	It was found that the nitrogen isotopic values of nitrate in PM2.5 (hereafter as delta15N-NO3-) ranged widely from -3.1% to + 11.4%, with a mean value of 3.5 +- 3.7%.	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
31967806-0	2020	Investigation into the Concentrations and Sources of Nitrates and Nitrites in Milk and Plant-based Powders.	Nitrates	53-61	Weaning weight-maternal milk	Bos taurus	78-82
32117389-8	2020	An RNA sequencing analysis revealed that ZmCHB101 regulates the expression of genes involved in nitrate transport, including ZmNRT2.1 and ZmNRT2.2.	Nitrates	96-103	putative high affinity nitrate transporter	Zea mays	138-146
31967806-1	2020	Milk powders in the United States (US) may contain nitrates and nitrites from several potential sources.	Nitrates	51-59	Weaning weight-maternal milk	Bos taurus	0-4
31967806-4	2020	To date, the concentrations of nitrates and nitrites in milk and plant-based powders in the US is unknown.	Nitrates	31-39	Weaning weight-maternal milk	Bos taurus	56-60
32117389-9	2020	The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate.	Nitrates	72-79	nitrate transport 2	Zea mays	138-146
31967806-10	2020	Background nitrate concentrations in US produced milk powder samples averaged 17 +- 12 mg/kg.	Nitrates	11-18	Weaning weight-maternal milk	Bos taurus	49-53
32117389-9	2020	The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate.	Nitrates	72-79	putative high affinity nitrate transporter	Zea mays	151-159
32117389-9	2020	The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate.	Nitrates	223-230	nitrate transport 2	Zea mays	138-146
32117389-9	2020	The NIN-like protein (NLP) of maize, ZmNLP3.1, recognized the consensus nitrate-responsive cis-elements (NREs) in the promoter regions of ZmNRT2.1 and ZmNRT2.2, and activated the transcription of these genes in response to nitrate.	Nitrates	223-230	putative high affinity nitrate transporter	Zea mays	151-159
31429204-10	2020	MCT-associated up-regulation of nNOS in the lung appeared to be dose-dependently prevented by nitrate treatment.	Nitrates	94-101	nitric oxide synthase 1	Rattus norvegicus	32-36
31429204-13	2020	The suppression of MnSOD and nNOS expression by nitrate could be interpreted as reduced demand of endogenous antioxidant defence in this model.	Nitrates	48-55	superoxide dismutase 2	Rattus norvegicus	19-24
31429204-13	2020	The suppression of MnSOD and nNOS expression by nitrate could be interpreted as reduced demand of endogenous antioxidant defence in this model.	Nitrates	48-55	nitric oxide synthase 1	Rattus norvegicus	29-33
31581317-2	2020	A wheat nitrate-inducible NAC transcription factor, TaNAC2 plays a critical role in promoting crop growth and nitrogen use efficiency and now we show its role in seed vigour.	Nitrates	8-15	NAC domain-containing protein 2	Triticum aestivum	52-58
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	212-219	high-affinity nitrate transporter 2.1	Triticum aestivum	118-124
31581317-3	2020	We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour.	Nitrates	58-65	NAC domain-containing protein 2	Triticum aestivum	16-22
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	212-219	NAC domain-containing protein 2	Triticum aestivum	156-162
31581317-3	2020	We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour.	Nitrates	58-65	high-affinity nitrate transporter 2.1	Triticum aestivum	48-52
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	212-219	high-affinity nitrate transporter 2.1	Triticum aestivum	20-24
31581317-3	2020	We identified a TaNAC2 regulated gene that is a NRT2-type nitrate transporter TaNRT2.5 with a key role in seed vigour.	Nitrates	58-65	high-affinity nitrate transporter 2.1	Triticum aestivum	78-84
31581317-4	2020	Overexpressing TaNAC2-5A increases grain nitrate concentration and seed vigour by directly binding to the promoter of TaNRT2.5-3B and positively regulating its expression.	Nitrates	41-48	NAC domain-containing protein 2	Triticum aestivum	15-21
31581317-6	2020	In Xenopus oocyte assays TaNRT2.5 requires a partner protein TaNAR2.1 to give nitrate transport activity, and the transporter locates to the tonoplast in a tobacco leaf transient expression system.	Nitrates	78-85	high-affinity nitrate transporter 2.1	Triticum aestivum	25-31
31581317-6	2020	In Xenopus oocyte assays TaNRT2.5 requires a partner protein TaNAR2.1 to give nitrate transport activity, and the transporter locates to the tonoplast in a tobacco leaf transient expression system.	Nitrates	78-85	probable high-affinity nitrate transporter-activating protein 2.2	Triticum aestivum	61-69
31581317-7	2020	Furthermore, in the root TaNRT2.5 and TaNRT2.1 function in post-anthesis acquisition of soil nitrate.	Nitrates	93-100	high-affinity nitrate transporter 2.1	Triticum aestivum	25-31
31581317-7	2020	Furthermore, in the root TaNRT2.5 and TaNRT2.1 function in post-anthesis acquisition of soil nitrate.	Nitrates	93-100	high-affinity nitrate transporter 2.1	Triticum aestivum	38-44
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	59-66	high-affinity nitrate transporter 2.1	Triticum aestivum	18-24
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	59-66	high-affinity nitrate transporter 2.1	Triticum aestivum	20-24
31581317-8	2020	Overexpression of TaNRT2.5-3B increases seed vigour, grain nitrate concentration and yield, while RNA interference of TaNRT2.5 has the opposite effects The TaNAC2-NRT2.5 module has a key role in regulating grain nitrate accumulation and seed vigour.	Nitrates	212-219	high-affinity nitrate transporter 2.1	Triticum aestivum	18-24
31730198-4	2020	Histological analysis of the root tip revealed decreased cell division and elongation in the cytokinin receptor double mutant ahk2/ahk4 as compared with wild-type plants under a sufficient nitrate regime.	Nitrates	189-196	histidine kinase 2	Arabidopsis thaliana	126-130
31928660-1	2020	Physiological effects of ammonium (NH4+) and nitrate (NO3-) on tea have confirmed that tea plants prefer NH4+ as the dominant nitrogen (N) source.	Nitrates	45-52	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
31730198-4	2020	Histological analysis of the root tip revealed decreased cell division and elongation in the cytokinin receptor double mutant ahk2/ahk4 as compared with wild-type plants under a sufficient nitrate regime.	Nitrates	189-196	CHASE domain containing histidine kinase protein	Arabidopsis thaliana	131-135
31956150-3	2020	In mild HF patients, log (ANP + BNP) in the AO was an independent predictor of (CS-AO) cGMP among hemodynamics and nitrate therapy.	Nitrates	115-122	natriuretic peptide B	Homo sapiens	32-35
31816715-4	2020	No water films are observed in the proposed TRGO-based potassium (K+-TRGO-ISEs) and nitrate (NO3--TRGO-ISEs) selective SC-ISEs.	Nitrates	84-91	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
31445413-9	2020	Significant enhancement of nitrate in Pb-O-Cl-N-S particles was observed when the RH was greater than 60%, emphasizing the importance of heterogeneous hydrolysis of N2O5 on the formation of Pb(NO3)2.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	193-196
32038262-0	2019	Dietary Nitrate Protects Against Skin Flap Ischemia-Reperfusion Injury in Rats via Modulation of Antioxidative Action and Reduction of Inflammatory Responses.	Nitrates	8-15	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	38-42
32038262-3	2019	Here, we evaluated the therapeutic effects of dietary nitrate on skin flap recovery following ischemia reperfusion (IR).	Nitrates	54-61	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	70-74
32038262-5	2019	It was found that oral administration of nitrate increased serum nitrate and nitrite levels, protected cells from apoptosis, and attenuated flap tissue edema.	Nitrates	41-48	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	140-144
32038262-7	2019	Moreover, the macrophage and neutrophil infiltration in the flap was significantly attenuated by nitrate supplementation, as were the pro-inflammatory cytokines.	Nitrates	97-104	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	60-64
32038262-8	2019	In sum, we found that oral administration of nitrate can attenuate skin flap IR injury through the regulation of oxidative stress and inflammatory response.	Nitrates	45-52	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	72-76
32038669-6	2019	To validate the physiological response of plants to DHS exposure, real-time RT-PCR analyses were performed on those genes most involved in nitrate acquisition, such as ZmNRT2.1, ZmNRT2.2, ZmMHA2 (coding for two high-affinity nitrate transporters and a PM H+-proton pump), ZmNADH:NR, ZmNADPH:NR, and ZmNiR (coding for nitrate reductases and nitrite reductase).	Nitrates	139-146	nitrate transport 2	Zea mays	168-176
31797274-11	2020	Notable relations between Ca2+ and NO3-, particularly in PM10 at Goa, indicated their release from mining related activities.	Nitrates	35-39	tripartite motif containing 47	Homo sapiens	65-68
32001953-4	2020	Moreover, nitrate significantly decreased triglyceride content and mRNA expression levels of Ppargamma in liver and Glut4 in skeletal muscle.	Nitrates	10-17	peroxisome proliferator activated receptor gamma	Mus musculus	93-102
32001953-4	2020	Moreover, nitrate significantly decreased triglyceride content and mRNA expression levels of Ppargamma in liver and Glut4 in skeletal muscle.	Nitrates	10-17	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	116-121
31595477-1	2020	Nitrification is the microbial-mediated transformation of ammonium (NH4 +) into nitrate (NO3 -).	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
31791519-5	2020	Compared with the dry season, the fact that water quality worsened in the wet season and that there were positive correlations for nitrate (NO3-) between water and the corresponding soil samples suggested that the riparian-soil environment affected the adjacent water quality mainly in the wet season.	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
31595466-2	2020	Plants assimilate inorganic form of N [nitrate (NO3 -), nitrite (NO2 -) or ammonium (NH4 +)] and incorporate into amino acids.	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
31765889-6	2020	Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages.	Nitrates	17-24	arginase, liver	Mus musculus	140-150
31595466-6	2020	In cytosol the NO3 - is reduced to NO2 - by cytosolic nitrate reductase (NR) and the produced NO2 - is further reduced to NH4 + by nitrite reductase (NiR) in plastids.	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
31604144-7	2020	Sialin, a known nitrate transporter, was detected in myoblasts; nitrate uptake decreased after sialin knockdown.	Nitrates	16-23	solute carrier family 17 member 5	Homo sapiens	0-6
31604144-8	2020	Inhibition of chloride channel 1 (CLC1) also led to significantly decreased uptake of nitrate.	Nitrates	86-93	chloride voltage-gated channel 1	Homo sapiens	14-32
31604144-8	2020	Inhibition of chloride channel 1 (CLC1) also led to significantly decreased uptake of nitrate.	Nitrates	86-93	chloride voltage-gated channel 1	Homo sapiens	34-38
31765889-6	2020	Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages.	Nitrates	17-24	early growth response 2	Mus musculus	152-157
31765889-6	2020	Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages.	Nitrates	17-24	interleukin 10	Mus musculus	159-164
31883320-8	2019	In this context, the fact that animals jointly receiving GTN and DSF developed tolerance to GTN, and in animals that in addition to GTN and DSF also received LA such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2.	Nitrates	257-264	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	343-347
31641075-0	2020	SDG8-mediated histone methylation and RNA processing function in the response to nitrate signaling.	Nitrates	81-88	histone-lysine N-methyltransferase	Arabidopsis thaliana	0-4
31641075-2	2020	Here, we show that the Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP 8 (SDG8) mediates genome-wide changes in H3K36 methylation at specific genomic loci functionally relevant to nitrate treatments.	Nitrates	210-217	histone-lysine N-methyltransferase	Arabidopsis thaliana	84-102
31641075-2	2020	Here, we show that the Arabidopsis (Arabidopsis thaliana) histone methyltransferase SET DOMAIN GROUP 8 (SDG8) mediates genome-wide changes in H3K36 methylation at specific genomic loci functionally relevant to nitrate treatments.	Nitrates	210-217	histone-lysine N-methyltransferase	Arabidopsis thaliana	104-108
31606555-8	2020	In both reactors, nitrate (NO3-) formed as the main byproduct at the anode, but in the undivided reactor it was reduced at the stainless steel cathode to ammonia.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
31883320-8	2019	In this context, the fact that animals jointly receiving GTN and DSF developed tolerance to GTN, and in animals that in addition to GTN and DSF also received LA such tolerance did not develop, is - in our opinion - a sufficient premise to conclude that the nitrate tolerance certainly is not caused by a decrease in the activity of any of the ALDH isoenzymes present in the rat liver, including ALDH2.	Nitrates	257-264	aldehyde dehydrogenase 2 family member	Rattus norvegicus	395-400
31909112-10	2020	Since NO is oxidized to NO2 - and nitrate (NO3 -), it is common practice to quantitate total NO2 -/NO3 - as a measure of the NO level.	Nitrates	34-41	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
31767742-7	2019	Specifically, we find that the ocean can exhibit fundamental transitions in the species of nitrogen dominating the fixed-N inventory--from nitrate (NO3 -) to ammonium (NH4 +)--and that as this transition occurs, the inventory can partially collapse relative to P due to progressive spatial decoupling between the loci of NH4 + oxidation, NO3 - reduction, and nitrogen fixation.	Nitrates	139-146	NBL1, DAN family BMP antagonist	Homo sapiens	148-151
31766976-11	2019	Conclusions A higher relative abundance of oral nitrate-reducing bacteria was associated with lower insulin resistance and plasma glucose in the full cohort and with mean systolic BP in participants with normotension.	Nitrates	48-55	insulin	Homo sapiens	100-107
31867024-5	2019	Nitrate uptake and assimilation is enhanced in omeprazole treated plants through changes in nitrate reductase activity, primary metabolism, and gene expression.	Nitrates	0-7	nitrate reductase [NADH] 1	Zea mays	92-109
31867024-6	2019	Omeprazole enhances nitrate assimilation through an interaction with nitrate reductase, altering its activation state and affinity for nitrate as a substrate.	Nitrates	20-27	nitrate reductase [NADH] 1	Zea mays	69-86
31656997-3	2019	Probability of perched and shallow groundwater nitrate concentration > 3 mg L-1 exhibited strong spatial autocorrelation, with effective ranges of 1091 m and 3743 m from semivariogram, respectively.	Nitrates	47-54	immunoglobulin kappa variable 1-16	Homo sapiens	76-79
31557655-3	2019	NO3--N produced in Anammox could be further reduced through (partial) denitrification and dissimilatory nitrate reduction to ammonium (DNRA).	Nitrates	104-111	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
31600544-2	2019	Research has revealed an alternative NO-generating pathway, independent of NO synthase (NOS), in which the inorganic anions nitrate (NO3-) and nitrite (NO2-) are serially reduced to form NO.	Nitrates	124-131	nitric oxide synthase 1, neuronal	Mus musculus	75-86
31539849-1	2019	The conversion of natural saltmarshes to shrimp aquaculture ponds can potentially influence the biogeochemical cycling of nutrients in coastal wetlands, but its impact on the dynamics of sediment dissimilatory nitrate (NO3-) reduction remains poorly understood.	Nitrates	210-217	NBL1, DAN family BMP antagonist	Homo sapiens	219-222
31350908-7	2019	This muscle nitrate reservoir has been found to be an important source of nitrite and nitric oxide (NO) via its reduction by tissue xanthine oxidoreductase.	Nitrates	12-19	xanthine dehydrogenase	Homo sapiens	132-155
31350908-10	2019	Consistent with these observations, and with previous suggestions of active muscle nitrate transport, we present western blot data to show significant expression of the active nitrate/nitrite transporter sialin in human skeletal muscle.	Nitrates	83-90	solute carrier family 17 member 5	Homo sapiens	204-210
31350908-10	2019	Consistent with these observations, and with previous suggestions of active muscle nitrate transport, we present western blot data to show significant expression of the active nitrate/nitrite transporter sialin in human skeletal muscle.	Nitrates	176-183	solute carrier family 17 member 5	Homo sapiens	204-210
31414122-4	2019	Exposure to Pb specifically stimulated NRT1.1-mediated nitrate uptake.	Nitrates	55-62	nitrate transporter 1.1	Arabidopsis thaliana	39-45
31634463-0	2019	Dysregulated NO/PDE5 signaling in the sickle cell mouse lower urinary tract: Reversal by oral nitrate therapy.	Nitrates	94-101	phosphodiesterase 5A, cGMP-specific	Mus musculus	16-20
31634463-8	2019	Nitrate treatment normalized plasma nitrite levels, relaxation of urethra to sodium nitroprusside, PDE5 phosphorylation in the urethra and bladder, and urine volume in Sickle mice.	Nitrates	0-7	phosphodiesterase 5A, cGMP-specific	Mus musculus	99-103
31634463-10	2019	Inorganic nitrate supplementation normalized voiding in Sickle mice through mechanisms likely involving upregulation of PDE5 activity.	Nitrates	10-17	phosphodiesterase 5A, cGMP-specific	Mus musculus	120-124
31450447-1	2019	Simultaneous determination of nitrate (NO3 ) and nitrite (NO2 ) in vegetables was performed on a poly(1-vinylimidazole-co-ethylene dimethacrylate) (VIM-EDMA) monolithic column by capillary liquid chromatography (LC) with UV detection.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
31414122-5	2019	Loss of function of NRT1.1 in nrt1.1-knockout mutants resulted in greater Pb toxicity and higher Pb accumulation in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and null-mutants for NRT1.2, NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	116-123	nitrate transporter 1.1	Arabidopsis thaliana	20-26
31727786-3	2019	Here, we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean (Glycine max) within two highly conserved nitrate-induced (NOI) domains.	Nitrates	145-152	RPM1 interacting protein 4	Arabidopsis thaliana	55-59
31414122-5	2019	Loss of function of NRT1.1 in nrt1.1-knockout mutants resulted in greater Pb toxicity and higher Pb accumulation in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and null-mutants for NRT1.2, NRT2.1, NRT2.2, NRT2.4, and NRT2.5.	Nitrates	116-123	nitrate transporter 1.1	Arabidopsis thaliana	30-34
31616875-0	2019	The riddle of the forbidden UV absorption of aqueous nitrate: the oscillator strength of the n   pi* transition in NO3- including second order vibronic coupling.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
31697768-3	2019	Nitrification is a process which consumes oxygen and ammonium (NH4+), and supplies nitrate (NO3-).	Nitrates	83-90	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
31465952-7	2019	The mechanism explorations revealed that micro-aerobic condition not only particularly enriched the sulfide-oxidizing, nitrate-reducing bacteria (soNRB) but also promoted the microbial zonation of sulfate-reducing bacteria (SRB) and soNRB, thereby achieving more S0 transformation in the effluent.	Nitrates	119-126	chaperonin containing TCP1 subunit 4	Homo sapiens	197-238
31418937-0	2019	The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep.	Nitrates	23-30	LOC105613195	Ovis aries	53-60
31541562-6	2019	ABSTRACT: Dietary nitrate (NO3 - ) supplementation, which increases plasma nitrite (NO2 - ) concentration, has been reported to attenuate skeletal muscle fatigue development.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Mus musculus	27-30
31279186-8	2019	In conclusion, the combined use of Ca(NO3)2 addition and AER capping is a more promising strategy for the control of sedimentary phosphorus release than the single use of Ca(NO3)2 addition from the point of view of both the control efficiency of P release from sediments and the releasing risk of the added nitrate.	Nitrates	307-314	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
31661786-1	2019	Soil nitrate-nitrogen (NO3--N) is one of the primary factors used to control nitrogen topdressing application during the crop growth period.	Nitrates	5-21	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
31203953-5	2019	This fully automated analyzer had a limit of detection of 0.02 mumol L-1 for nitrite and 0.14 mumol L-1 for nitrate.	Nitrates	108-115	L1 cell adhesion molecule	Homo sapiens	100-103
31203953-7	2019	With automated dilution, the calibration curve for nitrate was linear up to a concentration of 400 mumol L-1 (R2 &gt; 0.999).	Nitrates	51-58	L1 cell adhesion molecule	Homo sapiens	105-108
31623611-14	2019	This implies that drinking water nitrate levels should be taken into account when evaluating the effect of meat consumption on endogenous formation of NOC.	Nitrates	33-40	nocturnin	Homo sapiens	151-154
31185400-7	2019	We noted: i) The areal nitrate reduction rates for the marsh, fringe, and estuary zones were 29.29 +- 3.28, 18.83 +- 1.31, and 10.83 +- 0.62 mg N m-2 day-1, respectively; ii) the majority (~93%) of NO3 was converted to N2O, indicating denitrification was the major NO3 reduction pathway; iii) the submerged, eroded marsh soils (peat fringe zone) will play a large role in nitrate reduction due to increased contact time with the surface water.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
31626627-0	2019	Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana.	Nitrates	0-7	OBF binding protein 4	Arabidopsis thaliana	19-23
31626627-0	2019	Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana.	Nitrates	0-7	xyloglucan endotransglucosylase/hydrolase 9	Arabidopsis thaliana	24-28
31626627-12	2019	Based on these findings we propose a novel mechanism by which OBP4 antagonistically controls XTH9 expression and the OBP4-XTH9 module elaborately sustains LR development in response to nitrate treatment.	Nitrates	185-192	OBF binding protein 4	Arabidopsis thaliana	117-126
31618861-3	2019	The Kendall test shows significant declines in fecal coliform bacteria (FCB) and ammonia (NH3) in the upper reaches and increases in nitrate (NO3) and NH3 in the lower reaches.	Nitrates	133-140	NBL1, DAN family BMP antagonist	Homo sapiens	142-145
31323502-1	2019	This study investigated the feasibility of a new biological nitrogen removal process that integrates sulfur-driven autotrophic denitratation (NO3- NO2-) and anaerobic ammonium oxidation (Anammox) for simultaneous removal of nitrate and ammonium from industrial wastewater.	Nitrates	224-231	NBL1, DAN family BMP antagonist	Homo sapiens	142-145
31560362-0	2019	Rb3SbF3(NO3)3: an excellent antimony nitrate nonlinear optical material with a strong second harmonic generation response fabricated by a rational multi-component design.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
31560362-1	2019	A novel antimony fluoride nitrate, Rb3SbF3(NO3)3, fabricated by a rational multi-component design, has been successfully synthesized by a rapid evaporation concentration method.	Nitrates	8-33	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
31185400-7	2019	We noted: i) The areal nitrate reduction rates for the marsh, fringe, and estuary zones were 29.29 +- 3.28, 18.83 +- 1.31, and 10.83 +- 0.62 mg N m-2 day-1, respectively; ii) the majority (~93%) of NO3 was converted to N2O, indicating denitrification was the major NO3 reduction pathway; iii) the submerged, eroded marsh soils (peat fringe zone) will play a large role in nitrate reduction due to increased contact time with the surface water.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	265-268
31195279-1	2019	In the framework of the Life+ InSiTrate project, a pilot-plant was established to demonstrate the viability of inducing in-situ heterotrophic denitrification to remediate nitrate (NO3-)-polluted groundwater.	Nitrates	171-178	NBL1, DAN family BMP antagonist	Homo sapiens	180-183
31581560-6	2019	The results show that the methanogenesis gene, Mcr, was undetected but more carbon fixation genes than nitrate reduction and sulfate genes were found.	Nitrates	103-110	nuclear receptor subfamily 3 group C member 2	Homo sapiens	47-50
31336256-2	2019	However, the major issues of nitrate (NO3--N) residue and instability in the current combination of nitritation and anammox process necessitates being addressed efficiently.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
31264223-5	2019	Biochemical and molecular analyses revealed that NLP7, a master nitrate regulatory transcription factor, directly bound to the nitrate-responsive cis-element (NRE)-like motif of the T5120 promoter and activated T5120 transcription.	Nitrates	64-71	NIN like protein 7	Arabidopsis thaliana	49-53
31431511-0	2019	Phosphorylation-mediated dynamics of nitrate transceptor NRT1.1 regulate auxin flux and nitrate signaling in lateral root growth.	Nitrates	37-44	nitrate transporter 1.1	Arabidopsis thaliana	57-63
31264223-6	2019	In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation.	Nitrates	42-49	NIN like protein 7	Arabidopsis thaliana	92-96
31264223-6	2019	In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation.	Nitrates	42-49	NIN like protein 7	Arabidopsis thaliana	142-146
31264223-6	2019	In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation.	Nitrates	156-163	NIN like protein 7	Arabidopsis thaliana	92-96
31264223-6	2019	In addition, T5120 partially restored the nitrate signalling and assimilation phenotypes of nlp7 mutant, suggesting that T5120 is involved in NLP7-mediated nitrate regulation.	Nitrates	156-163	NIN like protein 7	Arabidopsis thaliana	142-146
31264223-7	2019	Interestingly, the expression of T5120 was regulated by the nitrate sensor NRT1.1.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	75-79
31264223-8	2019	Therefore, T5120 is modulated by NLP7 and NRT1.1 to regulate nitrate signalling.	Nitrates	61-68	NIN like protein 7	Arabidopsis thaliana	33-37
31264223-8	2019	Therefore, T5120 is modulated by NLP7 and NRT1.1 to regulate nitrate signalling.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	42-46
31295558-17	2019	A non-significant positive correlation was observed between the change in salivary sialin and salivary NO3- concentrations (r = 0.18, P = 0.06).	Nitrates	103-107	solute carrier family 17 member 5	Homo sapiens	83-89
31431511-0	2019	Phosphorylation-mediated dynamics of nitrate transceptor NRT1.1 regulate auxin flux and nitrate signaling in lateral root growth.	Nitrates	88-95	nitrate transporter 1.1	Arabidopsis thaliana	57-63
31431511-2	2019	NRT1.1 regulates lateral root (LR) development by modulating nitrate-dependent basipetal auxin export and nitrate-mediated signal transduction.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	0-4
31431511-2	2019	NRT1.1 regulates lateral root (LR) development by modulating nitrate-dependent basipetal auxin export and nitrate-mediated signal transduction.	Nitrates	106-113	nitrate transporter 1.1	Arabidopsis thaliana	0-4
31431511-5	2019	The phosphomimetic NRT1.1T101D form showed fast lateral mobility and membrane partitioning that facilitated auxin flux under low-nitrate conditions.	Nitrates	129-136	nitrate transporter 1.1	Arabidopsis thaliana	19-23
31465193-2	2019	Herein, an innovative bifunctional nanocomposite HFO@TPR was developed for synchronous nitrate/phosphate elimination from water.	Nitrates	87-94	translocated promoter region, nuclear basket protein	Homo sapiens	53-56
31465193-3	2019	A macroporous polystyrene microspheres modified with triethylamine functional groups was synthesized as the host of HFO@TPR for selective nitrate removal, and Fe(III) hydroxide (HFO) nanoparticles were implanted inside as the active species for specific phosphate removal.	Nitrates	138-145	translocated promoter region, nuclear basket protein	Homo sapiens	120-123
31465193-4	2019	Compared to other commercial adsorbents, HFO@TPR exhibited outstanding selectivity and preference toward nitrates and phosphates, and the coexisting anions exert an insignificant effect on adsorption performance.	Nitrates	105-113	translocated promoter region, nuclear basket protein	Homo sapiens	45-48
31465193-5	2019	Such exceptional bifuntionality of HFO@TPR was achieved through two pathways, that is, nitrate was preferentially adsorbed by the fixed triethylamine groups through the electrostatic attraction, and phosphate was preferentially captured by the encapsulated HFO nanoparticles through the inner-sphere complexation.	Nitrates	87-94	translocated promoter region, nuclear basket protein	Homo sapiens	39-42
31465193-7	2019	In addition, column adsorption experiments demonstrated that HFO@TPR could eliminate nitrate from 18 to &lt;10 mg N/L with the treatment capacity of ~600 bed volume (BV), and meanwhile remove phosphate from 2.5 to &lt;0.2 mg P/L with the treatment capacity of ~750 BV.	Nitrates	85-92	translocated promoter region, nuclear basket protein	Homo sapiens	65-68
31431511-6	2019	By contrast, non-phosphorylatable NRT1.1T101A showed low lateral mobility and oligomerized at the plasma membrane (PM), where it induced endocytosis via the clathrin-mediated endocytosis and microdomain-mediated endocytosis pathways under high-nitrate conditions.	Nitrates	244-251	nitrate transporter 1.1	Arabidopsis thaliana	34-38
31548257-3	2019	Here we show that AvrRpm1 induces ADP-ribosylation of RIN4 proteins from both Arabidopsis and soybean within two highly conserved nitrate-induced (NOI) domains.	Nitrates	130-137	RPM1 interacting protein 4	Arabidopsis thaliana	54-58
31087098-0	2019	Ammonium and nitrate regulate NH4+ uptake activity of Arabidopsis ammonium transporter AtAMT1;3 via phosphorylation at multiple C-terminal sites.	Nitrates	13-20	anthranilate synthase alpha subunit 1	Arabidopsis thaliana	87-93
31087098-3	2019	Here, we showed that the Arabidopsis root epidermis-expressed ammonium transporter AtAMT1;3 was dynamically (de-)phosphorylated at multiple sites in the cytosolic C-terminal region (CTR) responding to ammonium and nitrate signals.	Nitrates	214-221	ammonium transporter 1;3	Arabidopsis thaliana	83-91
31129334-5	2019	During the nitrate reduction by Zn-Ag/hv/HCOOH process, rapid reduction of NO3- to NO2- was primarily caused by ZnAg bimetal.	Nitrates	11-18	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
31325834-10	2019	Nitrate exposure was associated with a significantly increased risk of limb deficiencies (RR for 1 mg/L (RR1) = 1.26, 95% CI = 1.05, 1.51) in models without well restriction.	Nitrates	0-7	ribonucleotide reductase catalytic subunit M1	Homo sapiens	90-103
31200219-6	2019	Elevated groundwater nitrate concentrations (&gt;50 mg L-1) create a large stoichiometric demand for bioavailable DOC in discharging groundwater.	Nitrates	21-28	immunoglobulin kappa variable 1-16	Homo sapiens	55-58
31513626-3	2019	We discovered a hyper PHB-accumulating denitrifying bacterium, Zobellella denitrificans ZD1 (referred as strain ZD1 hereafter) capable of using non-sterile crude glycerol (a waste from biodiesel production) and nitrate to produce high PHB yield under saline conditions.	Nitrates	211-218	ZD1	Homo sapiens	88-91
31513626-3	2019	We discovered a hyper PHB-accumulating denitrifying bacterium, Zobellella denitrificans ZD1 (referred as strain ZD1 hereafter) capable of using non-sterile crude glycerol (a waste from biodiesel production) and nitrate to produce high PHB yield under saline conditions.	Nitrates	211-218	ZD1	Homo sapiens	112-115
31513626-5	2019	In this study, we discovered a complete pathway of glycerol conversion to PHB, a novel PHB synthesis gene cluster, a salt-tolerant gene cluster, denitrifying genes, and an assimilatory nitrate reduction gene cluster in the ZD1 genome.	Nitrates	185-192	ZD1	Homo sapiens	223-226
31513626-7	2019	Higher levels of PHB accumulation were linked to higher expression levels of the PHB synthesis gene cluster in ZD1 grown with glycerol and nitrate under saline conditions.	Nitrates	139-146	ZD1	Homo sapiens	111-114
31141766-4	2019	Further it was found that the sensor is highly selective towards fluoride over other anions including chloride, bromide, iodide, nitrate, borate, perchlorate and can quantitatively detect fluoride at ppb level with a limit of detection of 0.02 mg/ L or 20 ppb.	Nitrates	129-136	histatin 1	Homo sapiens	200-203
31348674-1	2019	Over the last decade there has been substantial interest in the health and athletic performance benefits associated with acute and chronic dietary nitrate (NO3-) supplementation.	Nitrates	147-154	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
31325834-10	2019	Nitrate exposure was associated with a significantly increased risk of limb deficiencies (RR for 1 mg/L (RR1) = 1.26, 95% CI = 1.05, 1.51) in models without well restriction.	Nitrates	0-7	ribonucleotide reductase catalytic subunit M1	Homo sapiens	105-108
31325834-11	2019	Nitrate was also weakly associated with an increased risk of congenital heart defects (RR1 = 1.13, 95%CI = 0.93, 1.51) and neural tube defects (RR1 = 1.18, 95%CI = 0.93, 1.51) in models with well restriction (<10%).	Nitrates	0-7	ribonucleotide reductase catalytic subunit M1	Homo sapiens	87-90
31325834-11	2019	Nitrate was also weakly associated with an increased risk of congenital heart defects (RR1 = 1.13, 95%CI = 0.93, 1.51) and neural tube defects (RR1 = 1.18, 95%CI = 0.93, 1.51) in models with well restriction (<10%).	Nitrates	0-7	ribonucleotide reductase catalytic subunit M1	Homo sapiens	144-147
31173908-3	2019	In the present study, we tested the hypothesis that lack of myoglobin expression would decrease nitrate levels in skeletal muscle.	Nitrates	96-103	myoglobin	Mus musculus	60-69
31173908-4	2019	We observed a modest but significant decrease of nitrate level in skeletal muscle of myoglobin deficient mice compared to littermate control mice (17.3 vs 12.8 nmol/g).	Nitrates	49-56	myoglobin	Mus musculus	85-94
31173908-5	2019	In contrast, a NOS inhibitor, L-NAME or a low nitrite/nitrate diet treatment led to more pronounced decreases of nitrate levels in the skeletal muscle of both control and myoglobin deficient mice.	Nitrates	54-61	myoglobin	Mus musculus	171-180
31437742-6	2019	Dissolved organic N was the dominant component of total N followed by nitrate (NO3-) and ammonium (NH4+).	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
31173908-5	2019	In contrast, a NOS inhibitor, L-NAME or a low nitrite/nitrate diet treatment led to more pronounced decreases of nitrate levels in the skeletal muscle of both control and myoglobin deficient mice.	Nitrates	113-120	myoglobin	Mus musculus	171-180
31667449-6	2019	The main source of PON-derived aerosols is monoterpene nitrates that have been chemically processed to lose their nitrate functionality through aqueous chemistry.	Nitrates	55-62	paraoxonase 1	Homo sapiens	19-22
31552707-6	2019	Untreated Ins2Akita mice showed significant increases in urinary albumin excretion, histological changes, glomerular macrophage recruitment, the inflammatory cytokine KC-GRO/CXCL1, and urinary thiobarbituric acid reactive substances (TBARS) excretion as an indicator of oxidative stress, along with a significant reduction in kidney nitrate + nitrite levels compared to control mice at 18 weeks of age.	Nitrates	333-340	insulin II	Mus musculus	10-14
32634879-3	2020	Nitrate in blood is taken up by sialin, a nitrate transporter and concentrated in salivary glands and secreted into saliva.	Nitrates	0-7	solute carrier family 17 member 5	Homo sapiens	32-38
31667449-7	2019	In contrast, the major portion of aqueous aerosol and in-cloud PON, which retains its nitrate moiety, are soluble isoprene nitrates.	Nitrates	86-93	paraoxonase 1	Homo sapiens	63-66
31128332-6	2019	The SOM results support the in-reservoir findings, revealing 2-MIB and Geosmin to be associated with high ammonium relative to nitrate for all 5 reservoirs.	Nitrates	127-134	MIB E3 ubiquitin protein ligase 1	Homo sapiens	63-66
31128393-1	2019	Nitrate (NO3-) and bicarbonate (HCO3-) are harmful for the water quality and can potentially create negative impacts to aquatic organisms, crops and humans.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31456696-4	2019	Most of the ingested NO is in the form of nitrate (   NO 3 -   ).	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	54-58
30980427-1	2019	RATIONALE: The nitrogen and oxygen (delta15 N, delta18 O, and delta17 O values) isotopic compositions of nitrate (NO3 - ) are crucial tracers of nutrient nitrogen (N) sources and dynamics in aquatic systems.	Nitrates	105-112	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
30980427-8	2019	The uncertainties for dissolved nitrate reference materials (USGS32, USGS34, USGS35, IAEA-NO3 ) were +-0.2% for delta15 N values and +-0.3% for delta18 O values using IRMS.	Nitrates	32-39	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
31390768-4	2019	Batch experiments were conducted on water samples contaminated by 300 mg L-1 of nitrate.	Nitrates	80-87	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
31390768-6	2019	The results showed that almost complete nitrate removal (&gt;99.8%) was always achieved after 15 min at a concentration of bimetallic nanoparticles higher than 0.2 g L-1.	Nitrates	40-47	immunoglobulin kappa variable 1-16	Homo sapiens	166-169
31211619-11	2019	Serum nitrate levels were increased in antibiotic-treated Pxr+/+and Pxr-/- mice.	Nitrates	6-13	nuclear receptor subfamily 1, group I, member 2	Mus musculus	58-61
30949701-5	2019	Key breakthroughs include elucidation of the mechanisms underlying post-translational regulation of NIN-LIKE PROTEIN (NLP) and PHOSPHATE STARVATION RESPONSE (PHR) family transcription factors, which function as master regulators of responses to nitrate and phosphate starvation, respectively.	Nitrates	245-252	ninein like	Homo sapiens	100-116
31211619-11	2019	Serum nitrate levels were increased in antibiotic-treated Pxr+/+and Pxr-/- mice.	Nitrates	6-13	nuclear receptor subfamily 1, group I, member 2	Mus musculus	68-71
31227868-5	2019	All nitrate produced by anammox bacteria (57 mg N-NO3- L-1 day-1) was consumed, leading to a nitrogen removal efficiency of 97.5%.	Nitrates	4-11	L1 cell adhesion molecule	Homo sapiens	55-58
31382524-1	2019	: Dietary nitrate (NO3-) has been reported to improve endothelial function (EF) and blood pressure (BP).	Nitrates	10-17	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
31172512-0	2019	A reevaluation of the contribution of NRT1.1 to nitrate uptake in Arabidopsis under low-nitrate supply.	Nitrates	48-55	nitrate transporter 1.1	Arabidopsis thaliana	38-44
31175188-12	2019	The fumarate reductase FccA is a highly abundant multifunctional periplasmic protein that acts to bridge the periplasm and temporarily store electrons in a variety of respiratory nodes, including metal, nitrate, and dimethyl sulfoxide respiration.	Nitrates	203-210	flavocytochrome c	Shewanella oneidensis MR-1	23-27
31071559-1	2019	Nitrate (NO3-) pollution is a serious problem worldwide.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31172512-1	2019	NRT1.1 has been previously characterized as a dual-affinity nitrate transporter in Arabidopsis, though several lines of evidence have raised questions regarding its high-affinity function in nitrate uptake.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	0-6
31172512-2	2019	Here, we show that the induction of NRT2.1- and NRT2.2-mediated nitrate uptake interferes with measurements of the contribution of NRT1.1 to high-affinity uptake using nrt1.1 mutants.	Nitrates	64-71	nitrate transporter 2:1	Arabidopsis thaliana	36-40
31172512-2	2019	Here, we show that the induction of NRT2.1- and NRT2.2-mediated nitrate uptake interferes with measurements of the contribution of NRT1.1 to high-affinity uptake using nrt1.1 mutants.	Nitrates	64-71	nitrate transporter 2:1	Arabidopsis thaliana	48-52
31172512-4	2019	This triple mutant has a lower rate of nitrate uptake than the nrt2.1/2.2 double mutant under low external nitrate supply, resulting in a lower growth rate than that of the double mutant.	Nitrates	39-46	nitrate transporter 2:1	Arabidopsis thaliana	63-67
31172512-4	2019	This triple mutant has a lower rate of nitrate uptake than the nrt2.1/2.2 double mutant under low external nitrate supply, resulting in a lower growth rate than that of the double mutant.	Nitrates	107-114	nitrate transporter 2:1	Arabidopsis thaliana	63-67
31172512-5	2019	Therefore, we conclude that NRT1.1-mediated high-affinity nitrate uptake is necessary for plant growth under low-nitrate conditions.	Nitrates	58-65	nitrate transporter 1.1	Arabidopsis thaliana	28-32
31172512-5	2019	Therefore, we conclude that NRT1.1-mediated high-affinity nitrate uptake is necessary for plant growth under low-nitrate conditions.	Nitrates	113-120	nitrate transporter 1.1	Arabidopsis thaliana	28-32
31093850-11	2019	The nitrate/nitrite ratio was reduced in serum and in aortas of 6-month-old CD73-/- mice as compared to WT.	Nitrates	4-11	5' nucleotidase, ecto	Mus musculus	76-80
31306468-2	2019	The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production.	Nitrates	31-38	nitric oxide synthase 2, inducible	Mus musculus	55-59
31051259-1	2019	Nitrate (NO3-) contained in food and beverages can transiently increase nitric oxide (NO) availability following a stepwise reduction to nitrite (NO2-) by commensal bacteria in the oral cavity.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
31306468-2	2019	The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production.	Nitrates	31-38	nitric oxide synthase 2, inducible	Mus musculus	75-106
31306468-2	2019	The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) production.	Nitrates	31-38	nitric oxide synthase 2, inducible	Mus musculus	108-112
31306468-6	2019	Furthermore, we show that the severity of the pathology of Salmonella- induced colitis as well as the nitrate-dependent growth of Salmonella in the lumen of the inflamed intestine are reduced in mice that lack Ccr2 and, therefore, inflammatory monocytes in the tissues.	Nitrates	102-109	chemokine (C-C motif) receptor 2	Mus musculus	210-214
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Nitrates	95-102	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
31054393-1	2019	Denitrifying bioreactors remove nitrate (NO3-) from agricultural drainage and are slated to be an integral part of nitrogen reduction strategies in the Mississippi River Basin.	Nitrates	32-39	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
31251057-4	2019	The strongly bound neighboring lattice oxygen pair cooperates in NO oxidation to form bridging nitrate (NO3-) intermediates, which can facilely transform into monodentate NO3- by a concerted rotation with simultaneous O2 adsorption onto the resulting oxygen vacancy.	Nitrates	95-102	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
30845346-0	2019	Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: Decreased insulin clearance, but lack of blood pressure-lowering.	Nitrates	72-79	insulin	Homo sapiens	91-98
30845346-7	2019	CONCLUSIONS: In healthy adults, acute physiological elevations of plasma [glucose] and [insulin] result in a lack of BP-lowering with dietary nitrate.	Nitrates	142-149	insulin	Homo sapiens	88-95
31078007-6	2019	The presence of nitrate (NO3-) slowed the removal of ReO4- from solution, presumably through chemical reduction and precipitation.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
30986667-7	2019	Furthermore, the total ammonium (NH4+) and nitrate (NO3-) concentration in modified natural zeolite were increased by 11.1 and 21.5% respectively as compared to raw zeolite.	Nitrates	43-50	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	96-103	NIN like protein 7	Arabidopsis thaliana	26-44
31095461-1	2019	Dietary nitrate ( NO3- ) supplementation has been shown to reduce resting blood pressure.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
30936488-7	2019	By contrast, Heimdallarchaeum LC2 and LC3 genomes encode enzymes potentially enabling the oxidation of organic substrates using nitrate or oxygen as electron acceptors.	Nitrates	128-135	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	38-41
30980891-11	2019	Similarly, nitrate inhibited the overexpression of myeloperoxidase and iNOS observed under dysbiosis (p < 0.05).	Nitrates	11-18	myeloperoxidase	Rattus norvegicus	51-66
30980891-11	2019	Similarly, nitrate inhibited the overexpression of myeloperoxidase and iNOS observed under dysbiosis (p < 0.05).	Nitrates	11-18	nitric oxide synthase 2	Rattus norvegicus	71-75
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	96-103	NIN like protein 7	Arabidopsis thaliana	46-50
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	96-103	Plant regulator RWP-RK family protein	Arabidopsis thaliana	56-60
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	128-135	NIN like protein 7	Arabidopsis thaliana	26-44
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	128-135	NIN like protein 7	Arabidopsis thaliana	46-50
30903620-7	2019	The transcription factors NIN-LIKE PROTEIN 7 (NLP7) and NLP6, which act as master regulators of nitrate signaling by binding to nitrate-responsive elements (NREs), are expressed at the SAM and flowering is delayed in single and double mutants.	Nitrates	128-135	Plant regulator RWP-RK family protein	Arabidopsis thaliana	56-60
31084876-8	2019	The FT expression levels in the chl1-5flc-3 double mutant plants recovered when the FLC mutation was introduced into chl1-5 plants and the up-regulation of FLC transcripts in the chl1-5 mutant plants was not related to nitrate availability.	Nitrates	219-226	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	156-159
31084876-9	2019	Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner.	Nitrates	255-262	nitrate transporter 1.1	Arabidopsis thaliana	26-32
31084876-9	2019	Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner.	Nitrates	255-262	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	81-84
31058993-6	2019	AtTCP20 is a plant-specific TF, which can modulate LR development in response to nitrate.	Nitrates	81-88	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	0-7
31084876-9	2019	Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner.	Nitrates	255-262	nitrate transporter 1.1	Arabidopsis thaliana	155-161
31084876-9	2019	Our findings suggest that NRT1.1 affects flowering time via interaction with the FLC-dependent flowering pathway to influence its target gene FT, and that NRT1.1 may be included in an additional signaling pathway that represses the expression of FLC in a nitrate-independent manner.	Nitrates	255-262	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	246-249
31113864-5	2019	Using bone marrow-derived macrophages from WT and RIP2-KO mice, we show that loss of RIP2 leads to deficient FcgammaR signaling and reactive oxygen species (ROS) production upon FcgammaR cross-linking without affecting cytokine secretion, phagocytosis, or nitrate/nitrite production.	Nitrates	256-263	receptor (TNFRSF)-interacting serine-threonine kinase 2	Mus musculus	85-89
30933788-6	2019	A day by treatment interaction was also observed on plasma methemoglobin concentrations, with concentrations being lower from steers one day after initiation of treatments than from collected one day prior to treatment initiation and concentrations being lowest in steers treated with nitrate plus 79R4.	Nitrates	285-292	hemoglobin subunit gamma 2	Homo sapiens	59-72
30928741-4	2019	Across-catchment differences in upstream spring water nitrate concentrations predicted differences in annual nitrate loads at catchment outlets (range &lt;1-72 megagrams NO3-N 365 d-1), and nitrate loads were higher in wet seasons and wet years, reflecting strong groundwater influences.	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	170-173
30928792-5	2019	Further analysis showed that ammonia-oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) in the O1 and O2 tanks together contributed to the conversion of ammonia nitrogen to nitrate, but the process of heterotrophic denitrification was inhibited in the A1 and A2 tanks because of insufficient carbon sources.	Nitrates	184-191	immunoglobulin kappa variable 2D-40	Homo sapiens	106-115
30928741-7	2019	However, high nitrate loads from groundwater mean current NO3-N waterway management and rehabilitation practices targeting waterway stock exclusion by fencing alone will be insufficient to reduce annual NO3-N export.	Nitrates	14-21	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
30943068-7	2019	siRNA knockdown of Rcn2 dramatically increased production of the nitric oxide (NO) breakdown products nitrite and nitrate by endothelial cells but not by smooth muscle cells.	Nitrates	114-121	reticulocalbin 2	Mus musculus	19-23
30831514-3	2019	Batch denitrification experiments showed that nitrate was completely removed at 5 h without nitrite accumulation under the optimum conditions of COD/NO3--N concentration ratio of 5.0-5.5 and initial pH of 7.2 +- 0.1.	Nitrates	46-53	NBL1, DAN family BMP antagonist	Homo sapiens	149-152
30870003-2	2019	In both heart and skeletal muscle, nitrate increases fatty acid oxidation capacity, and in the latter case, this involves up-regulation of peroxisome proliferator-activated receptor (PPAR)alpha expression.	Nitrates	35-42	peroxisome proliferator activated receptor alpha	Mus musculus	183-193
30785000-3	2019	HPR achieved a higher nitrate removal activity (maximum:19.66 +- 0.63 mg NO3--N/(L h)) with excellent resistance to high nitrate loading (up to 400 mg/L NO3--N) compared to that of the control groups.	Nitrates	22-29	haptoglobin-related protein	Homo sapiens	0-3
30785000-3	2019	HPR achieved a higher nitrate removal activity (maximum:19.66 +- 0.63 mg NO3--N/(L h)) with excellent resistance to high nitrate loading (up to 400 mg/L NO3--N) compared to that of the control groups.	Nitrates	121-128	haptoglobin-related protein	Homo sapiens	0-3
30785000-4	2019	Nitrate removal rate of HPR fitted the Michaelis-Menten kinetic model (R2 = 0.98, p &lt; 0.01) well, and the denitrification followed the zero-order rate law.	Nitrates	0-7	haptoglobin-related protein	Homo sapiens	24-27
31146317-6	2019	Additionally, the NO3-/Cl- versus Cl- diagram and principal component analysis (PCA) show that the contamination of nitrate in the study area was due to human activities (i.e. agriculture and domestic sewage disposal).	Nitrates	116-123	NBL1, DAN family BMP antagonist	Homo sapiens	18-21
30870003-3	2019	Here, we investigated whether dietary nitrate modifies mitochondrial function in the hypoxic heart in a PPARalpha-dependent manner.	Nitrates	38-45	peroxisome proliferator activated receptor alpha	Mus musculus	104-113
30870003-7	2019	This switch away from fatty acid oxidation was reversed by nitrate treatment in hypoxic WT but not Ppara-/- mice, indicating a PPARalpha-dependent effect.	Nitrates	59-66	peroxisome proliferator activated receptor alpha	Mus musculus	127-136
30797805-0	2019	Zr4+ ions embedded chitosan-soya bean husk activated bio-char composite beads for the recovery of nitrate and phosphate ions from aqueous solution.	Nitrates	98-105	brain expressed associated with NEDD4 1	Homo sapiens	33-37
30797805-1	2019	Removal of nitrate and phosphate ions using Zr4+ ions embedded chitosan-soya bean husk activated bio-char composite beads (Zr-CS-SAC) was carried out by batch mode to overcome the environmental problems due to eutrophication.	Nitrates	11-18	brain expressed associated with NEDD4 1	Homo sapiens	77-81
31019249-0	2019	Author Correction: Nitrate-NRT1.1B-SPX4 cascade integrates nitrogen and phosphorus signalling networks in plants.	Nitrates	19-26	immunoglobulin superfamily member 9	Homo sapiens	27-31
30849493-10	2019	The findings in this study that nitration of hIAPP promotes its oligomer formation and thus exacerbates its cytotoxicity suggests a possible link between the nitrite (or the sum of nitrite and nitrate) levels and T2D, and ameliorated nitration of hIAPP by diminishing nitrative stress might be a promising therapeutic strategy for T2D.	Nitrates	193-200	islet amyloid polypeptide	Homo sapiens	45-50
31016305-6	2019	When normalized to nitrate concentration, the denitrification rate (NDR) followed a positive trend with either the concentration or proportion of tFDOC, and a negative trend with the proportion of nFDOC, suggesting tFDOC was potentially favorable while nFDOC was unfavorable for denitrifying degradation.	Nitrates	19-26	serine/threonine kinase 38	Homo sapiens	68-71
31138751-5	2019	Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness.	Nitrates	149-156	interferon gamma	Mus musculus	60-69
31138751-5	2019	Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness.	Nitrates	149-156	signal transducer and activator of transcription 1	Mus musculus	70-75
31138751-5	2019	Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness.	Nitrates	149-156	nitric oxide synthase 2, inducible	Mus musculus	76-80
31138751-5	2019	Additional experiments with infected mice indicate that the IFN-gamma/STAT1/iNOS axis, while essential for parasite control, also supplies a pool of nitrate that serves as a source for anaerobic respiration and supports overgrowth of Enterobacteriaceae Together, these data reveal a trade-off in intestinal immunity after oral infection of C57BL/6J mice with T. gondii, in which inducible nitric oxide synthase (iNOS) is required for parasite control, while this host enzyme is responsible for specific modification of the composition of the microbiome that contributes to pathology.IMPORTANCE Toxoplasma gondii is a protozoan parasite and a leading cause of foodborne illness.	Nitrates	149-156	nitric oxide synthase 2, inducible	Mus musculus	412-416
30807951-6	2019	The higher DNF and DNRA rates observed after the addition of NOC indicates that nitrate reduction was enhanced more by NOC than acetate.	Nitrates	80-87	nocturnin	Homo sapiens	61-64
30807951-6	2019	The higher DNF and DNRA rates observed after the addition of NOC indicates that nitrate reduction was enhanced more by NOC than acetate.	Nitrates	80-87	nocturnin	Homo sapiens	119-122
31064131-5	2019	The calibration graph for nitrates was linear in the range of 0.5-35 microg mL-1 with a correlation coefficient of 0.9999.	Nitrates	26-34	L1 cell adhesion molecule	Mus musculus	76-80
31112557-1	2019	Nitrification, the microbial oxidation of ammonia (NH3) to nitrite (NO2-) and NO2- to nitrate (NO3-), plays a vital role in ocean nitrogen cycling.	Nitrates	86-93	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
31064131-7	2019	The calibration graph for nitrites (after oxidation to nitrates) was linear in the range of 0.5-15 microg mL-1 with a correlation coefficient of 0.9972.	Nitrates	55-63	L1 cell adhesion molecule	Mus musculus	106-110
31064131-9	2019	The nitrate concentrations in the saliva samples were found in the range of 8.98-18.52 mug mL-1, whereas nitrite was in the range of 3.50-5.34 mug mL-1.	Nitrates	4-11	L1 cell adhesion molecule	Mus musculus	91-95
30878866-1	2019	Elimination of nitrogen pollution from wastewater containing high-strength nitrate (NO3--N) is a significant issue to prevent deterioration of water quality and eutrophication of receiving water body.	Nitrates	75-82	NBL1, DAN family BMP antagonist	Homo sapiens	84-87
30995881-7	2019	Tempol-treated DJ -1 -/- mice presented higher serum nitrite/nitrate levels than vehicle-treated DJ -1 -/- mice, suggesting a role of the NO system in the high blood pressure of this model.	Nitrates	61-68	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	15-20
30995881-10	2019	The renal-selective silencing of Ucp2 led to normalization of blood pressure and serum nitrite/nitrate ratio in DJ -1 -/- mice.	Nitrates	95-102	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	33-37
30763914-5	2019	Especially, the L20 resin with the triethylammonium functional group was demonstrated to possess high selectivity toward nitrate with the highest distribution coefficient among all tested resins.	Nitrates	121-128	immunoglobulin kappa variable 3D-11	Homo sapiens	16-19
30763914-7	2019	The L20 resin could be reused after many adsorption-desorption cycles with most of its virgin adsorption capacity for advanced wastewater treatment, indicating its great potential for the selective and efficient removal of nitrate from large amounts of municipal wastewater or surface water.	Nitrates	223-230	immunoglobulin kappa variable 3D-11	Homo sapiens	4-7
30776171-1	2019	Increasing nitrogen (N) deposition in subtropical forests in south China causes N saturation, associated with significant nitrate (NO3 - ) leaching.	Nitrates	122-129	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
30784837-1	2019	Nitrate (NO3-) is a key component of secondary inorganic aerosols and PM2.5.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30772502-9	2019	Nitrate restored decreased red blood cells count, hemoglobin concentration, and hematocrit to control levels in diabetic rats; in addition, nitrate restored decreased serum, kidney, and liver EPO levels to near normal values.	Nitrates	140-147	erythropoietin	Rattus norvegicus	192-195
30822646-1	2019	Nitrate (NO3-N) export from row crop agricultural systems with subsurface tile drainage continues to be a major water quality concern.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30772502-12	2019	CONCLUSION: Long-term and low dose of nitrate had beneficial effects against anemia in obese type 2 diabetic rats; these effects were associated with increased EPO and HIF-1 levels in kidney and liver as well as increased circulating EPO, testosterone, and iron.	Nitrates	38-45	erythropoietin	Rattus norvegicus	160-163
30772502-12	2019	CONCLUSION: Long-term and low dose of nitrate had beneficial effects against anemia in obese type 2 diabetic rats; these effects were associated with increased EPO and HIF-1 levels in kidney and liver as well as increased circulating EPO, testosterone, and iron.	Nitrates	38-45	erythropoietin	Rattus norvegicus	234-237
31087918-5	2019	The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2.	Nitrates	83-90	Putative anthocyanidin reductase	Zea mays	338-342
30967583-0	2019	GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis.	Nitrates	33-40	G-protein-coupled receptor 1	Arabidopsis thaliana	0-4
30967583-0	2019	GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis.	Nitrates	33-40	G protein alpha subunit 1	Arabidopsis thaliana	9-13
30967583-7	2019	Physiological and molecular validation of nitrate-response revealed the sensitivity of germination to low N in the double mutant and differential expression of nitrate transporter (and nitrate reductase in all three mutants).	Nitrates	42-49	nitrate reductase 1	Arabidopsis thaliana	185-202
31087918-5	2019	The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2.	Nitrates	191-198	Putative anthocyanidin reductase	Zea mays	241-245
31087918-5	2019	The results showed that during the 2015-2016 winter wheat/summer maize season, the nitrate nitrogen from the soil leaching occurred mainly in the summer maize season (rainy season), with the nitrate nitrogen leaching amount reaching 59.9 kg hm-2, while the nitrate nitrogen leaching amount during the winter wheat season was only 2.12 kg hm-2.	Nitrates	191-198	Putative anthocyanidin reductase	Zea mays	241-245
31087918-8	2019	In summary, the results showed that the nitrate nitrogen leaching values were 10.5, 59.9, and 136.5 kg hm-2 for nitrogen fertilizer applications of 0, 300, and 450 kg hm-2, respectively, during extreme precipitation in a wet year (2015).	Nitrates	40-47	Putative anthocyanidin reductase	Zea mays	103-107
31087918-8	2019	In summary, the results showed that the nitrate nitrogen leaching values were 10.5, 59.9, and 136.5 kg hm-2 for nitrogen fertilizer applications of 0, 300, and 450 kg hm-2, respectively, during extreme precipitation in a wet year (2015).	Nitrates	40-47	Putative anthocyanidin reductase	Zea mays	167-171
31087918-9	2019	The value of nitrate nitrogen leaching in the maize season of 2013 (dry year), 2015 (normal year), and 2016 (wet year) accounted for 9%, 10%, and 20% for the 300 kg hm-2 of nitrogen fertilizer applied, respectively.	Nitrates	13-20	Putative anthocyanidin reductase	Zea mays	165-169
31087918-10	2019	However, the value of nitrate nitrogen leaching in the maize season of 2013 (dry year), 2015 (normal year), and 2016 (wet year) accounted for 11%, 17% and 30% of the 450 kg hm-2 of nitrogen fertilizer applied.	Nitrates	22-29	Putative anthocyanidin reductase	Zea mays	173-177
30935372-3	2019	Plant chloride channels (CLCs) are transport proteins for anions including Cl- and nitrate (NO3-), and are critical for nutrition uptake and transport, adjustment of cellular turgor, stomatal movement, signal transduction, and Cl- and NO3- homeostasis under salt stress.	Nitrates	83-90	NBL1, DAN family BMP antagonist S homeolog	Xenopus laevis	92-95
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrates	174-181	L1 cell adhesion molecule	Homo sapiens	164-167
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrates	174-181	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
31087940-4	2019	The results showed that the dissolved N2O concentration in the agricultural headwater stream ranged from 0.26 to 1.28 mug L-1 with an annual mean value of 0.57 mug L-1, with nitrate (NO3--N, with an annual mean concentration of 1.45 mg L-1) as the predominant reactive N form.	Nitrates	174-181	L1 cell adhesion molecule	Homo sapiens	164-167
30055294-3	2019	Nitrate improves tissue oxygenation and has been shown to modulate skeletal muscle tissue metabolism via transcriptional changes, including through the activation of peroxisome proliferator-activated receptor alpha (PPARalpha), a master regulator of fat metabolism.	Nitrates	0-7	peroxisome proliferator activated receptor alpha	Mus musculus	166-214
30055294-3	2019	Nitrate improves tissue oxygenation and has been shown to modulate skeletal muscle tissue metabolism via transcriptional changes, including through the activation of peroxisome proliferator-activated receptor alpha (PPARalpha), a master regulator of fat metabolism.	Nitrates	0-7	peroxisome proliferator activated receptor alpha	Mus musculus	216-225
30670112-0	2019	Dietary nitrate consumption and risk of CHD in women from the Nurses" Health Study.	Nitrates	8-15	choline dehydrogenase	Homo sapiens	40-43
30670112-3	2019	Therefore, the aim of this investigation was to examine the relationship between habitual dietary nitrate intakes and risk of CHD in women from the Nurses" Health Study.	Nitrates	98-105	choline dehydrogenase	Homo sapiens	126-129
30670112-9	2019	When comparing the highest quintile of nitrate intake with the lowest quintile, in aged-adjusted analysis there was a protective association for CHD (RR=0 77, 95 % CI 0 68, 0 97; P=0 0002) which dissipated after further adjustment for smoking, physical activity, BMI and race (RR=0 91; 95 % CI 0 80, 1 04; P=0 27).	Nitrates	39-46	choline dehydrogenase	Homo sapiens	145-148
30869514-5	2019	NMR titration studies suggest that only 1:1 complexes of Ln(III) with C2-POPhen formed in CH3OH in the presence of a significant amount of nitrate, while both 1:1 and 2:1 complexes species could form between C2-POPhen and Ln(III) perchlorate in CH3OH without nitrate ions.	Nitrates	139-146	complement C2	Homo sapiens	70-79
30641379-2	2019	The nitrate removal rate of the AnFB-MBR reached 1.22 g NO3--N L-1d-1 with NO3--N ranging 40-200 mg L-1 at hydraulic retention times of 1.0-5.0 h. The denitrification in the integrated system was simultaneously carried out by sulfur- and Fe0-oxidizing autotrophic denitrifiers.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
31049136-1	2019	Nitrate (NO3 -) supplementation is associated with exercise performance, oxygen uptake, blood flow, and blood pressure improvement, and it can act as an antioxidant agent.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30712424-0	2019	Dietary Nitrate Reduces Blood Pressure in Rats With Angiotensin II-Induced Hypertension via Mechanisms That Involve Reduction of Sympathetic Hyperactivity.	Nitrates	8-15	angiotensinogen	Rattus norvegicus	52-66
30712424-4	2019	In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension.	Nitrates	61-68	angiotensinogen	Rattus norvegicus	154-160
30712424-4	2019	In this study, we hypothesized that treatment with inorganic nitrate could prevent the increase in sympathetic nerve activity in an experimental model of Ang II (angiotensin II)-induced hypertension.	Nitrates	61-68	angiotensinogen	Rattus norvegicus	162-176
30712424-9	2019	Supplementation with nitrate normalized the expression of AT1Rs in rostral ventrolateral medulla and reduced sympathetic nerve activity, which was associated with attenuated development of hypertension.	Nitrates	21-28	angiotensin II receptor, type 1a	Rattus norvegicus	58-61
30685420-1	2019	Dietary nitrate (NO3-) supplementation via beetroot juice (BR) is known to improve endurance performance in untrained and moderately trained individuals.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
30972097-0	2019	NRT1.1 Regulates Nitrate Allocation and Cadmium Tolerance in Arabidopsis.	Nitrates	17-24	nitrate transporter 1.1	Arabidopsis thaliana	0-4
30968014-4	2019	Results indicate that nitrate can be removed from source waters using FCDI to concentrations &lt;1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1).	Nitrates	22-29	immunoglobulin kappa variable 1-16	Homo sapiens	108-111
30622055-4	2019	This work examines the effect of aluminum (Al) incorporation (0%, 12% and 24 mol% Al) on the interaction energy of chloride (Cl-) and nitrate (NO3-), and adsorption/desorption of sulfate (SO42-) onto Fh.	Nitrates	134-141	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
30894123-1	2019	BACKGROUND: Nutrition with ammonium (NH4+) can enhance the drought tolerance of rice seedlings in comparison to nutrition with nitrate (NO3-).	Nitrates	127-134	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
30968014-4	2019	Results indicate that nitrate can be removed from source waters using FCDI to concentrations &lt;1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1).	Nitrates	22-29	immunoglobulin kappa variable 1-16	Homo sapiens	156-159
30968014-4	2019	Results indicate that nitrate can be removed from source waters using FCDI to concentrations &lt;1 mg NO3-N L-1 though a lower quality target such as 10 mg L-1 would be more cost-effective, particularly where the influent nitrate concentration is high (50 mg NO3-N L-1).	Nitrates	22-29	immunoglobulin kappa variable 1-16	Homo sapiens	156-159
30458235-11	2019	Gene expression of Bax and caspase 3 was decreased in both the lung and submandibular gland with nitrate treatment, indicating attenuation of apoptosis.	Nitrates	97-104	BCL2-associated X protein	Mus musculus	19-22
30884848-1	2019	Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite.	Nitrates	106-113	nitrate reductase 1	Arabidopsis thaliana	0-17
30884848-1	2019	Nitrate reductase (NR) is important for higher land plants, as it catalyzes the rate-limiting step in the nitrate assimilation pathway, the two-electron reduction of nitrate to nitrite.	Nitrates	166-173	nitrate reductase 1	Arabidopsis thaliana	0-17
30458235-11	2019	Gene expression of Bax and caspase 3 was decreased in both the lung and submandibular gland with nitrate treatment, indicating attenuation of apoptosis.	Nitrates	97-104	caspase 3	Mus musculus	27-36
30617465-1	2019	PURPOSE: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
30865649-2	2019	In this study we use small flux chambers to examine ammonium (NH4+) and nitrate (NO3-) cycling across the sediment-water interface.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
30508798-2	2019	For the first time, mag-LDHs were applied to sonocatalytic reduction of nitrate (NO3-) and the reduction mechanism were determined by conducting kinetic tests and various spectroscopic analyses.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
30617465-3	2019	METHODS: In a randomised, counterbalanced, double-blind crossover study, 12 recreationally trained males ingested a nitrate-rich beetroot juice shot (BRJ) (6.2 mmol NO3-) or a nitrate-depleted placebo (PLA) (&lt; 0.004 mmol NO3-) 3 h prior to an intermittent sprint test (IST) in temperate (22  C, 35% RH) and hot conditions (30  C, 70% RH).	Nitrates	116-123	alcohol dehydrogenase iron containing 1	Homo sapiens	145-148
30645747-12	2019	NO3- concentration showed a linear relationship of excess NH4+, which suggests homogeneous gas-phase reaction of ammonia and nitric acid is possibly an important pathways of nitrate formation in the haze pollution process in Shenyang City.	Nitrates	174-181	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
30234781-12	2019	Furthermore, abnormal expression of DLK1-MEG3 expression was caused by hypermethylation status of IG-DMR, And methylation status of IG-DMR highly correlated with ET1 concentration and nitrate concentration, these might be one of the mechanisms for impaired endothelial function (coefficient = 0.5806, P = 0.0115; coefficient = -0.4883, P = 0.0398).	Nitrates	184-191	delta like non-canonical Notch ligand 1	Homo sapiens	36-40
30611943-4	2019	Non-sea-salt sulfate (nss-SO42-) constituted the major component of PM2.5, followed by ammonium (NH4+) and nitrate (NO3-) during winter, summer and autumn.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
30234781-12	2019	Furthermore, abnormal expression of DLK1-MEG3 expression was caused by hypermethylation status of IG-DMR, And methylation status of IG-DMR highly correlated with ET1 concentration and nitrate concentration, these might be one of the mechanisms for impaired endothelial function (coefficient = 0.5806, P = 0.0115; coefficient = -0.4883, P = 0.0398).	Nitrates	184-191	maternally expressed 3	Homo sapiens	41-45
30699248-7	2019	COD/NO3- -N ratio mainly controlled the rate of nitrate reduction and not directly partial denitrification selection; thus, it should be used to balance between denitrification rate and anammox rate.	Nitrates	48-55	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	0-3
30699248-7	2019	COD/NO3- -N ratio mainly controlled the rate of nitrate reduction and not directly partial denitrification selection; thus, it should be used to balance between denitrification rate and anammox rate.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
30759603-1	2019	Recent studies have identified aerosol nitrate (NO3-) as one of the most important inorganic ions; however, quantitative studies of aerosol NO3- sources are rarely undertaken.	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
30819094-6	2019	Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants.	Nitrates	178-185	NIN like protein 7	Arabidopsis thaliana	31-35
30819094-6	2019	Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants.	Nitrates	178-185	NIN like protein 7	Arabidopsis thaliana	162-166
30819094-6	2019	Furthermore, a mutated form of NLP7 that harbored amino acid substitutions at K867, D909, D911, and E913 required a far higher level of expression than wild-type NLP7 to restore nitrate-responsive gene expression and growth of nlp6 nlp7-1 double mutants.	Nitrates	178-185	NIN like protein 7	Arabidopsis thaliana	232-236
30676746-1	2019	Microbial strains and indigenous microbiota in soil slurries have been reported to use electrons from electrodes for nitrate (NO3-) reduction.	Nitrates	117-124	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
30359797-4	2019	At one RSC, with high nitrate (NO3-) inputs, retention of N (16-37%) and release of DOC (18-54%) were observed with the highest retention of N during summer, and the rates of N retention and DOC release were larger than that of the adjacent unrestored tributary (N: 5-8%, DOC: &lt;18%).	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
30223219-5	2019	Our results showed that all three tree species preferred ammonium (NH4+) over glycine and nitrate (NO3-), and NH4+ contributed 73% to the total N uptake from the soil.	Nitrates	90-97	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
30777103-4	2019	METHODS: The influences of endogenous and exogenous H2S on the expression of IDO1, iNOS and NF-kappaB and STAT3 signaling proteins were investigated using qPCR or western blot, and the production of nitric oxide (NO) was analyzed by nitrate/nitrite assay in Cse-/- mice and MCF-7 and SGC-7901 cells.	Nitrates	233-240	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	52-55
30326455-1	2019	Nitrate isotopes (delta15N-NO3- and delta18O-NO3-) are a potentially powerful tool for tracking the biological removal of reactive nitrogen (N) as it is transported from land to sea.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30326455-1	2019	Nitrate isotopes (delta15N-NO3- and delta18O-NO3-) are a potentially powerful tool for tracking the biological removal of reactive nitrogen (N) as it is transported from land to sea.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
30605314-1	2019	Measurements of the stable isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3-) enable identification of sources, dispersal, and fate of natural and contaminant NO3- in aquatic environments.	Nitrates	88-95	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
30605314-1	2019	Measurements of the stable isotope ratios of nitrogen (15N/14N) and oxygen (18O/16O) in nitrate (NO3-) enable identification of sources, dispersal, and fate of natural and contaminant NO3- in aquatic environments.	Nitrates	88-95	NBL1, DAN family BMP antagonist	Homo sapiens	184-187
30551041-1	2019	In this study, the synergy of high nitrite (NO2--N) accumulated partial-denitrification (PD) and anammox in a continuously fed upflow anaerobic sludge blanket (UASB) reactor was verified for simultaneous nitrate (NO3--N) and ammonia (NH4+-N) removal.	Nitrates	204-211	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
30624978-9	2019	Plasma nitrate-nitrite levels increased in IL-4-treated RUPP rats, while placental preproendothelin-1 expression, plasma TNF-alpha and IL-6, and AT1-AA decreased in IL-4-treated RUPP rats compared with untreated RUPP rats ( P &lt; 0.05).	Nitrates	7-14	interleukin 4	Rattus norvegicus	43-47
30604360-4	2019	We found that the application of Ca2+ could regulate the activity of plasma membrane H+-ATPase, for mitigating the increase of ammonium and the decrease of nitrate and phosphorus in soybean roots, which mitigated the inhibition on growth and improved the yield and grain quality of soybean under simulated acid rain stress.	Nitrates	156-163	plasma membrane ATPase 4	Glycine max	85-94
30180321-2	2019	In particular, nitrate concentrations exceeding the 50 mg L-1 limit established for drinking water pose the human health at risk.	Nitrates	15-22	L1 cell adhesion molecule	Homo sapiens	58-61
30407574-6	2019	More importantly, our data demonstrate that, when cultivated under full nitrate conditions, known to repress N remobilization due to sufficient N uptake from the soil, N remobilization efficiency can nevertheless be sharply and significantly increased by overexpressing ATG8 genomic sequences under the control of the ubiquitin promoter.	Nitrates	72-79	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	270-274
31459405-6	2019	This study evaluates the predictive capabilities of various ab initio methods in the calculation of Gibbs free energies of reaction for [Ln(NO3)]2+ compounds (with Ln = La to Lu), as nitrates are critical in traditional separation processes utilizing nitric acid.	Nitrates	183-191	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
30180321-12	2019	Nitrate was not homogeneously distributed in groundwater, being observed a large range of concentrations, from &lt;1 up to 162 mg L-1.	Nitrates	0-7	L1 cell adhesion molecule	Homo sapiens	130-133
30565947-2	2019	Herein, a selective surface defect elimination process with the help of hydrated nitrates was introduced into the perovskite/toluene solution to strip the undesired surface defects and vacancies and to boost the photoluminescence quantum yield of true-blue-light-emitting (at 466 nm) CsPb(Cl/Br)3 perovskite nanocrystals to the impressive value of 85%.	Nitrates	81-89	granzyme B	Homo sapiens	284-288
30559212-7	2019	Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed to nitrite-derived formation of NO species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to mediate the reduction of nitrite.	Nitrates	51-58	xanthine dehydrogenase	Homo sapiens	180-203
29672839-7	2019	Inhibition of cyclooxygenase 1 by aspirin, supplementation of PGI2 by beraprost, and inhibition of PGIS S-nitrosylation by N-acetyl-cysteine improved GTN-induced nitrate cross-tolerance in rats.	Nitrates	162-169	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	14-30
29672839-0	2019	S-Nitrosylation of Prostacyclin Synthase Instigates Nitrate Cross-Tolerance In Vivo.	Nitrates	52-59	prostaglandin I2 synthase	Homo sapiens	19-40
29672839-7	2019	Inhibition of cyclooxygenase 1 by aspirin, supplementation of PGI2 by beraprost, and inhibition of PGIS S-nitrosylation by N-acetyl-cysteine improved GTN-induced nitrate cross-tolerance in rats.	Nitrates	162-169	prostaglandin I2 synthase	Rattus norvegicus	99-103
29672839-3	2019	This study aimed to determine the role of PGIS S-nitrosylation in nitrate tolerance induced by nitroglycerin (GTN).	Nitrates	66-73	prostaglandin I2 synthase	Homo sapiens	42-46
29672839-8	2019	In patients, increased PGIS S-nitrosylation was associated with nitrate tolerance.	Nitrates	64-71	prostaglandin I2 synthase	Homo sapiens	23-27
29672839-9	2019	In conclusion, GTN induces nitrate cross-tolerance through PGIS S-nitrosylation at cysteine 231/441.	Nitrates	27-34	prostaglandin I2 synthase	Homo sapiens	59-63
29672839-6	2019	Enforced expression of mutated PGIS with C231/441A markedly abolished GTN-induced PGIS S-nitrosylation and nitrate cross-tolerance in Apoe-/- mice.	Nitrates	107-114	prostaglandin I2 (prostacyclin) synthase	Mus musculus	31-35
30312509-1	2019	Forest harvest in the boreal zone can increase the input of terrestrial materials such as dissolved organic carbon (DOC) and nitrate (NO3 - ) into nearby aquatic ecosystems, with potential effects on phytoplankton growth through enhanced nutrient (i.e., positive) or reduced light availability (i.e., negative), which may affect ecosystem productivity and consumer resource use.	Nitrates	125-132	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
29529688-5	2019	The concentration of myeloperoxidase was determined by enzyme-linked immunosorbent assay, the concentration of nitrate and nitrite with high performance liquid chromatography method.	Nitrates	111-118	myeloperoxidase	Homo sapiens	21-36
29529688-7	2019	RESULTS: The mean concentration of myeloperoxidase was significantly higher in the diabetic group compared to the control group (16.2+-4.9 vs. 3.7+-1.8; P&lt;0.001).The nitrite concentration was comparable in both groups while the concentration of nitrate was significantly higher in the diabetic group (41.2 [42.9] vs 31.9 [23]; P=0.017).	Nitrates	248-255	myeloperoxidase	Homo sapiens	35-50
29529688-8	2019	In this study, plasma myeloperoxidase (Spearman"s rho=0.421; P=0.004) and nitrate concentration was significantly positively associated with the HbA1c levels while nitrate concentration (Spearman"s rho=- 0.308; P=0.047) were was significantly positively negatively associated with the HbA1c levels.	Nitrates	164-171	myeloperoxidase	Homo sapiens	22-37
31844504-4	2019	The impact on wet deposition of nitrate is assessed using measurements from the National Atmospheric Deposition Program"s National Trends Network (NADP NTN).	Nitrates	32-39	neurturin	Homo sapiens	152-155
28803424-6	2019	Sharp increases in the nitrate concentration in surface water were related to the accumulation of contaminants in the soil and aeration zone during drought periods and the subsequent transport of these contaminants to groundwater and surface water via recharge infiltration after each drought period.	Nitrates	23-30	spen family transcriptional repressor	Homo sapiens	0-5
30526064-8	2019	Arginase-1 was negatively correlated with serum nitrite and nitrate (r = -0.8137 and r = -0.8444, respectively).	Nitrates	60-67	arginase 1	Homo sapiens	0-10
33828349-5	2019	Estimates obtained from the parametric g-formula, a marginal structural model, and a structural nested model indicate that chlorophyll a concentrations at Lock and Dam 1 were influenced by nitrate concentrations measured 86 to 109 km upstream, an area where four major industrial and municipal point sources discharge wastewater.	Nitrates	189-196	BCAS2 pre-mRNA processing factor	Homo sapiens	164-169
30847325-1	2019	Background: The aim of this study was calibration of a nitrate (NO3)/nitrite (NO2) database for estimated its dietary intakes.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	64-67
31328626-7	2019	Ammonia and nitrate were effectively removed by both adsorption materials resulting in a reduction of influent ammonia and nitrate concentrations to below the national discharge limits set for these compounds of &lt;=4 mg L-1 and &lt;=50 mg L-1, respectively.	Nitrates	12-19	immunoglobulin kappa variable 1-16	Homo sapiens	222-225
30502887-6	2019	The results of a classification and regression tree (CART) model indicate the difference in the influence of physical factors on groundwater nitrate concentrations between western and eastern Nebraska, namely that groundwater nitrate concentrations correspond with vadose zone thickness, effective hydraulic conductivity, and saturated thickness in the west, while in eastern Nebraska, concentrations are correlated with average percent sand in the topsoil (0-150 cm), well depth, and effective hydraulic conductivity.	Nitrates	226-233	CART prepropeptide	Homo sapiens	53-57
31328626-7	2019	Ammonia and nitrate were effectively removed by both adsorption materials resulting in a reduction of influent ammonia and nitrate concentrations to below the national discharge limits set for these compounds of &lt;=4 mg L-1 and &lt;=50 mg L-1, respectively.	Nitrates	12-19	immunoglobulin kappa variable 1-16	Homo sapiens	241-244
31438763-3	2019	We recently found how nitrate, present at the shoot apical meristem (SAM), controls flowering time In this short communication, we present data on the tissue-specific expression patterns of NITRATE REDUCTASE 1 (NIA1) and NIA2 in planta.	Nitrates	22-29	nitrate reductase 1	Arabidopsis thaliana	211-215
31438763-3	2019	We recently found how nitrate, present at the shoot apical meristem (SAM), controls flowering time In this short communication, we present data on the tissue-specific expression patterns of NITRATE REDUCTASE 1 (NIA1) and NIA2 in planta.	Nitrates	22-29	nitrate reductase 2	Arabidopsis thaliana	221-225
30064106-6	2019	The results of nitrate isotopes indicated that NO3- mainly originated from soil organic nitrogen (SON), chemical fertilizer (CF), and manure and sewage wastes (M&amp;S).	Nitrates	15-22	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
30064106-7	2019	The negative correlation of nitrate isotopic values with NO3-/Cl- ratios suggested the importance of denitrification in NO3- loss.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
30064106-7	2019	The negative correlation of nitrate isotopic values with NO3-/Cl- ratios suggested the importance of denitrification in NO3- loss.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
30064106-11	2019	The seasonal pattern of nitrate dynamics indicated the mixing of nitrified NO3- and denitrified NO3- between surface flow and groundwater flow under different hydrological conditions.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30064106-11	2019	The seasonal pattern of nitrate dynamics indicated the mixing of nitrified NO3- and denitrified NO3- between surface flow and groundwater flow under different hydrological conditions.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
30687454-4	2018	Methods and Results: Organic nitrates (ISMN, ISDN, and nitroglycerin (GTN)) augmented the oxidative burst and interleukin-6 release in cultured macrophages, whereas macitentan decreased the oxidative burst in isolated human leukocytes.	Nitrates	29-37	interleukin 6	Homo sapiens	110-123
30396103-1	2019	Nitrogen (N) removal in conventional bioretention systems is highly variable owing to the low nitrate (NO3-) elimination efficiency.	Nitrates	94-101	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
30583575-1	2018	The commercial P25 titania has been modified with transition metallic species (Cr, Co, Ni, and Cu), added by impregnation with aqueous solutions of the corresponding nitrates.	Nitrates	166-174	tubulin polymerization promoting protein	Homo sapiens	15-18
30530699-2	2018	These layers of heightened chlorophyll and/or phytoplankton concentrations are generally thought to be a consequence of a balance between light energy from above and a limiting nutrient flux from below, typically nitrate (NO3).	Nitrates	213-220	NBL1, DAN family BMP antagonist	Homo sapiens	222-225
30461282-6	2018	The experimental phase behavior shows that while the chloride salts induce both liquid-liquid phase separation (LLPS) and RC, the nitrate salts also induce LLPS, but RC becomes partial with La(NO3)3 and disappears with Y(NO3)3.	Nitrates	130-137	NBL1, DAN family BMP antagonist	Homo sapiens	193-196
30461282-6	2018	The experimental phase behavior shows that while the chloride salts induce both liquid-liquid phase separation (LLPS) and RC, the nitrate salts also induce LLPS, but RC becomes partial with La(NO3)3 and disappears with Y(NO3)3.	Nitrates	130-137	NBL1, DAN family BMP antagonist	Homo sapiens	221-224
30628384-4	2018	The main sources of nitrate pollution in the area were determined by means of 15N(NO3-) and 18O(NO3-) isotopes.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
31458367-0	2018	Highly Active and Durable Cu x Au(1-x) Ultrathin-Film Catalysts for Nitrate Electroreduction Synthesized by Surface-Limited Redox Replacement.	Nitrates	68-75	cut like homeobox 1	Homo sapiens	26-30
31458367-1	2018	Cu x Au(1-x) bimetallic ultrathin-film catalysts for nitrate electroreduction have been synthesized using electrochemical atomic layer deposition by surface-limited redox replacement of Pb underpotentially deposited layer.	Nitrates	53-60	cut like homeobox 1	Homo sapiens	0-4
31458367-4	2018	The synthesized Cu x Au(1-x) thin films feature up to two times higher nitrate electroreduction activity in acidic solution compared to bulk and thin-film Cu counterparts.	Nitrates	71-78	cut like homeobox 1	Homo sapiens	16-20
30628384-4	2018	The main sources of nitrate pollution in the area were determined by means of 15N(NO3-) and 18O(NO3-) isotopes.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
30628384-7	2018	The results show that there are three main factors affecting the nitrate concentration in the study area:animal manure and domestic sewage, NO3- in chemical fertilizer, and soil nitrogen.	Nitrates	65-72	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
30223124-3	2018	The required HRT to reach 98.5% COD removal was achieved at 7.5 h. Simultaneous CNP removal under denitrification rate of 199.4 mg/l.d gave high nitrate to nitrogen gas conversion of 74.6 mg/l.	Nitrates	145-152	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	80-83
30088840-13	2018	Nitrate treatment in diabetic rats significantly improved sperm parameters, epididymal weight, spermatogenesis and testicular histology as well as decreasing serum glucose and testicular p53 gene and miR-34b expression, although it had no effect on serum LH and FSH levels.	Nitrates	0-7	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	187-190
30145415-0	2018	Fabrication and characterization of a Cu-Pd-TNPs polymetallic nanoelectrode for electrochemically removing nitrate from groundwater.	Nitrates	107-114	C1GALT1 specific chaperone 1	Homo sapiens	44-48
30145415-1	2018	A novel Cu-Pd-TNPs (Copper-Palladium-TiO2 Nanopores) polymetallic nanoelectrode was fabricated, and then used to catalytically reduce dissolved nitrate in groundwater.	Nitrates	144-151	C1GALT1 specific chaperone 1	Homo sapiens	14-18
30145415-7	2018	The Cu-Pd-TNPs electrode gave a high nitrate reduction rate, removing 287.3% nitrate more than that was removed by a Ti nanoelectrode under the same conditions.	Nitrates	37-44	C1GALT1 specific chaperone 1	Homo sapiens	10-14
30145415-7	2018	The Cu-Pd-TNPs electrode gave a high nitrate reduction rate, removing 287.3% nitrate more than that was removed by a Ti nanoelectrode under the same conditions.	Nitrates	77-84	C1GALT1 specific chaperone 1	Homo sapiens	10-14
30145415-9	2018	Nitrate was completely removed using the Cu-Pd-TNPs electrode with a Pt anode at a NaCl concentration of 0.5 g L-1, little ammonia and almost no nitrite were detected in the treated solution.	Nitrates	0-7	C1GALT1 specific chaperone 1	Homo sapiens	47-51
30408861-2	2018	Nitrate was the most abundant ion in PM2.5 and substantially increased during haze pollution with the NO3-/SO42- mass ratio increasing from 0.78 during clean period to 1.1 during haze period.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
30408869-4	2018	In general, the N2O emission fluxes were positively correlated to nitrate (NO3-) concentrations in soil solution, supporting the important role of denitrification in N2O production, which was also modified by environmental factors such as soil temperature and moisture.	Nitrates	66-73	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
30088840-13	2018	Nitrate treatment in diabetic rats significantly improved sperm parameters, epididymal weight, spermatogenesis and testicular histology as well as decreasing serum glucose and testicular p53 gene and miR-34b expression, although it had no effect on serum LH and FSH levels.	Nitrates	0-7	microRNA 34b	Rattus norvegicus	200-207
30359537-4	2018	During a training session, plasma [ NO3- ] ( P &lt; 0.001) and plasma [ NO2- ] ( P &lt; 0.01) were higher in nitrate (N), whereas in pre- and posttests mean plasma [ NO3- ] and [ NO2- ] were not different between groups.	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
30216785-10	2018	Our results demonstrate that high anthocyanin accumulation in PAP1-D/fls1ko plants confers enhanced tolerance to nitrate-deficient conditions combined with high salinity.	Nitrates	113-120	lipin 1	Homo sapiens	62-66
30216785-11	2018	PAP1-D/fls1ko plants appeared to use absorbed nitrate efficiently during the nitrate reduction process.	Nitrates	46-53	lipin 1	Homo sapiens	0-4
30216785-11	2018	PAP1-D/fls1ko plants appeared to use absorbed nitrate efficiently during the nitrate reduction process.	Nitrates	77-84	lipin 1	Homo sapiens	0-4
30216785-12	2018	In addition, nitrate-related genes such as NRT1.1, NiA1 and NiA2 were upregulated in the PAP1-D/fls1ko plants.	Nitrates	13-20	lipin 1	Homo sapiens	89-93
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Nitrates	9-16	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
30337453-10	2018	This study showed that NH4 + toxicity is related to a nitrate-independent signaling function of NRT1.1 in Arabidopsis, characterized by enhanced NH4 + accumulation and altered NH4 + metabolism, which stimulates ethylene synthesis, leading to plant senescence.	Nitrates	54-61	nitrate transporter 1.1	Arabidopsis thaliana	96-102
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Nitrates	9-16	Src like adaptor	Homo sapiens	216-220
30138958-3	2018	METHODS: Nitrate oxygen (O-NO3 - ) is equilibrated with water oxygen (O-H2 O) at low pH and 80 C. Subsequently, the delta17 O and delta18 O values of equilibrated water are determined by CRDS, scaled to V-SMOW and V-SLAP and calibrated against nitrate standards (USGS-34, USGS-35 and IAEA-NO3).	Nitrates	9-16	NBL1, DAN family BMP antagonist	Homo sapiens	289-292
30085380-1	2018	RATIONALE: The stable nitrogen isotopic composition of nitrate (NO3 - ) can be an effective tool to identify NO3 - sources and understand nitrogen cycling.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	64-67
30284450-3	2018	Herein, we demonstrate the use of LIG, created with a low-cost UV laser, for electrochemical ion-selective sensing of plant-available nitrogen (i.e., both ammonium and nitrate ions: NH4+ and NO3-) in soil samples.	Nitrates	168-175	NBL1, DAN family BMP antagonist	Homo sapiens	191-194
30085380-1	2018	RATIONALE: The stable nitrogen isotopic composition of nitrate (NO3 - ) can be an effective tool to identify NO3 - sources and understand nitrogen cycling.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
30182316-3	2018	The results revealed that nitrate leaching over the entire crop growing season in Chinese vegetable systems was very high and averaged 79.1 kg N ha-1 and primarily resulted from extremely high N fertilizer inputs (in average 423 kg N ha-1).	Nitrates	26-33	solute carrier family 9 member B1	Homo sapiens	143-149
29902768-1	2018	Energy-rich bonds such as nitrates (NO3-) and percholorates (ClO4-) have an explosive nature; they are frequently encountered in high energy materials.	Nitrates	26-34	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
30182316-3	2018	The results revealed that nitrate leaching over the entire crop growing season in Chinese vegetable systems was very high and averaged 79.1 kg N ha-1 and primarily resulted from extremely high N fertilizer inputs (in average 423 kg N ha-1).	Nitrates	26-33	solute carrier family 9 member B1	Homo sapiens	232-238
30182316-4	2018	Nitrate leaching was, on the average, 63.9% greater in the greenhouse systems (98.0 kg N ha-1) than in open-field systems (59.8 kg N ha-1).	Nitrates	0-7	solute carrier family 9 member B1	Homo sapiens	87-93
30182316-4	2018	Nitrate leaching was, on the average, 63.9% greater in the greenhouse systems (98.0 kg N ha-1) than in open-field systems (59.8 kg N ha-1).	Nitrates	0-7	solute carrier family 9 member B1	Homo sapiens	131-137
30242656-1	2018	Identification and quantification of sources of nitrate (NO3-) in freshwater lakes provide useful information for management of eutrophication and improving water quality in lakes.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
28818018-5	2018	The best conditions found for the treatment - with satisfactory reduction of nitrate, formation of gaseous compounds and reproducibility - were at nitrate concentrations of 600 and 1000 mg L-1, current density of 1.1 mA cm-2 and without pH control, since in these conditions the production of gaseous compounds is higher than the production of nitrite.	Nitrates	147-154	immunoglobulin kappa variable 1-16	Homo sapiens	189-192
30113272-1	2018	Studies of rats have indicated that skeletal muscle plays a central role in whole-body nitrate ( NO3- )/nitrite ( NO2- )/nitric oxide (NO) metabolism.	Nitrates	87-94	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
30190419-0	2018	Early Senescence in Older Leaves of Low Nitrate-Grown Atxdh1 Uncovers a Role for Purine Catabolism in N Supply.	Nitrates	40-47	xanthine dehydrogenase 1	Arabidopsis thaliana	54-60
30190419-3	2018	Older leaves of the Atxdh1 mutant exhibited early senescence, lower soluble protein, and lower organic N levels as compared with wild-type older leaves when grown with 1 mm nitrate but were comparable to the wild type under 5 mm nitrate.	Nitrates	173-180	xanthine dehydrogenase 1	Arabidopsis thaliana	20-26
30190419-3	2018	Older leaves of the Atxdh1 mutant exhibited early senescence, lower soluble protein, and lower organic N levels as compared with wild-type older leaves when grown with 1 mm nitrate but were comparable to the wild type under 5 mm nitrate.	Nitrates	229-236	xanthine dehydrogenase 1	Arabidopsis thaliana	20-26
30190419-8	2018	The higher nitrate reductase activity in Atxdh1 leaves compared with wild-type leaves indicated a need for nitrate assimilation products.	Nitrates	11-18	xanthine dehydrogenase 1	Arabidopsis thaliana	41-47
30388086-3	2018	The mass specific area of the sulfur particles (a*) and hydrolysis kinetic constant (k1) were identified as the dominant parameters on the model outputs, i.e. nitrate (NO3-), NO2- and sulfate (SO42-) concentrations, confirming that the microbially catalyzed S0 hydrolysis is the rate-limiting step during S0-driven denitrification.	Nitrates	159-166	NBL1, DAN family BMP antagonist	Homo sapiens	168-171
30584441-1	2018	Context: We describe here the contributions of the Tehran lipid and glucose study (TLGS) to understanding different aspects of the nitrate (NO3)-nitrite (NO2)-nitric oxide (NO) pathway in health and disease.	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
30099301-5	2018	The nitrate ion concentration increase with time is consistent with a two-rate system-level model that is characterized by two asymptotic rates for NO3- creation by the plasma.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	148-151
30099301-9	2018	While both system-level models have some discrepancies with the measurements, the two-rate model based on the nitrate ion concentration is concluded to be more useful for determining the NO3- formation rates in the context of irrigation water enrichment.	Nitrates	110-117	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
30205097-6	2018	KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats.	Nitrates	55-62	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	265-268
30205097-6	2018	KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats.	Nitrates	55-62	programmed cell death 4	Rattus norvegicus	270-275
30205097-6	2018	KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats.	Nitrates	55-62	phosphofurin acidic cluster sorting protein 2	Rattus norvegicus	281-286
30205097-6	2018	KEY FINDINGS: The results of this study indicated that nitrate treatment ameliorated the sperm parameters, testicular morphometrical and stereological alterations, reduced blood glucose, the number of TUNEL positive cells and tubules, and testicular expressions of p53, Pdcd4, and Pacs2 mRNA as well as increased body weight, serum insulin and NOx levels, and testicular expression of miR-449a in streptozotocin-induced diabetic rats.	Nitrates	55-62	microRNA 449a	Rattus norvegicus	385-393
30229602-2	2018	From May to October 2017, six sampling points in the Qingmuguan river basin, Chongqing, were monitored every 24 d. Results showed that there was a great risk of nitrate pollution in the underground river system, because most NO3--N concentrations of the sampling points exceeded the threshold.	Nitrates	161-168	NBL1, DAN family BMP antagonist	Homo sapiens	225-228
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	Nitrates	187-194	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
29860169-5	2018	In the following reactions, both theoretical calculation and experimental results reveal that the generated BP+  recovers itself to BP by grabbing an electron from NO3- and the generated nitrate radicals (NO3 ) then decay to nitrogen oxides.	Nitrates	187-194	NBL1, DAN family BMP antagonist	Homo sapiens	205-208
30229602-12	2018	It is believed that soil organic nitrogen, NH4+ in fertilizer and rain, the mixing of manure and sewage, and NO3- in precipitation were the main nitrate sources in the outlet.	Nitrates	145-152	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
29886338-1	2018	Nitrate (NO3-) pollution in rivers caused by intensive human activities is becoming a serious problem in irrigated agricultural areas.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30271668-1	2018	The source of dietary nitrate (NO3) is mainly green, leafy vegetables, partially absorbed into blood through intestinal mucosa.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
30271668-3	2018	In 2012, sialin was first discovered as the mammalian membrane nitrate transporter in salivary glands and plays a key role in circulation of inorganic nitrate, providing a scientific basis for further investigation into the circulation and functions of nitrate.	Nitrates	63-70	solute carrier family 17 member 5	Homo sapiens	9-15
30271668-3	2018	In 2012, sialin was first discovered as the mammalian membrane nitrate transporter in salivary glands and plays a key role in circulation of inorganic nitrate, providing a scientific basis for further investigation into the circulation and functions of nitrate.	Nitrates	151-158	solute carrier family 17 member 5	Homo sapiens	9-15
29906753-7	2018	At HRT of 30 min, the NO3- removal efficiency could achieve above 90% with the nitrate-to-nitrite transformation ratio of 0.8, implying the great potential to apply the thiosulfate-driven denitratation &amp; anammox system for BNR with minimal sludge production.	Nitrates	79-86	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
29960262-7	2018	We observed that water-soluble inorganic ions, especially nitrate (NO3-) and ammonium, had stronger influences on 3 hormones.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
29913387-3	2018	Stable isotope values of nitrate (delta15NNO3-, delta18ONO3-) can complement conventional water quality monitoring programs to help differentiate natural sources of NO3- from anthropogenic inputs and estimate the processes involved in N cycling within an ecosystem.	Nitrates	25-32	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
29860091-3	2018	Also, this review focuses on the development of electrochemical label-free immunosensor for SOD1 and the recent advances in biosensing assay methods based on their catalytic and biological functions with various substrates including reactive oxygen species (superoxide anion radical, hydrogen peroxide), nitric oxide metabolites (nitrite, nitrate) and thiols using thiol oxidase activity.	Nitrates	339-346	superoxide dismutase 1	Homo sapiens	92-96
29913387-10	2018	After consideration of potential alternative sources (sewage, atmospheric deposition and groundwater) we concluded that there are three plausible interpretations for deviations from conservative mixing behaviour (1) NO3- uptake by assimilation (2) in situ NO3- production (from fixation-derived nitrogen and nitrification of sewage-derived effluents) and (3) input of groundwater nitrate carrying a denitrification signal.	Nitrates	380-387	NBL1, DAN family BMP antagonist	Homo sapiens	256-259
30344609-6	2018	The limit of detection (LOD) and the limit of quantification (LOQ) at 3sigma for hydroxylamine nitrate ranged from 0.3 to 3 and from 3.5 to 10 g L-1, respectively, for the nitrate system at three peaks with wavelengths between 3.8 and 9.8 mum.	Nitrates	95-102	immunoglobulin kappa variable 1-16	Homo sapiens	145-148
30371202-11	2018	This suggests that sGC downregulation occurs outside the renal vasculature, increases renal sodium retention, and contributes to nitrate resistance of sunitinib-induced hypertension.	Nitrates	129-136	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	19-22
30294630-1	2018	The presence of elevated nitrate (NO3-) and nitrite (NO2-) concentration in drinking water higher than the standard limits could endanger the health of consumers.	Nitrates	25-32	NBL1, DAN family BMP antagonist	Homo sapiens	34-37
30229313-5	2018	Prior studies show how nitrites and nitrates in red meat can lead to increased insulin resistance, dysregulated blood glucose levels, and elevated oxidative stress all leading to chronic diseases.	Nitrates	36-44	insulin	Homo sapiens	79-86
29727854-7	2018	The increase in the water table depth (from 10 to 30 m) and the decrease of the nitrate concentration (from 25 to 15 mg NO3--N) would lead to a rise in energy consumption in the ex situ treatment.	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
30294630-8	2018	Although, the average concentration of NO3- and NO2- in drinking water was lower than the national standard limits, but the non-carcinogenic risk assessment showed that the children and adults are at a significant risk via nitrate and nitrite in the rural Divandarreh County (TTHQ &gt; 1).	Nitrates	223-230	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
30188067-4	2018	Due to biological metabolism, the generation of methane in sewers was of 7.39 mg L-1; the decrease of nitrate and sulfate in sewage was 0.33 mg L-1 and 21.35 mg L-1, respectively.	Nitrates	102-109	immunoglobulin kappa variable 1-16	Homo sapiens	144-147
30188067-4	2018	Due to biological metabolism, the generation of methane in sewers was of 7.39 mg L-1; the decrease of nitrate and sulfate in sewage was 0.33 mg L-1 and 21.35 mg L-1, respectively.	Nitrates	102-109	immunoglobulin kappa variable 1-16	Homo sapiens	144-147
30063337-2	2018	With hydroquinone (BQH2) and 1,4-benzoquinone (BQ) as redox mediators, the photochemical oxidation of As(III) and reduction of nitrate (NO3-) was carefully investigated.	Nitrates	127-134	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
29894929-7	2018	Interestingly, the PhP under study were biodegraded even in the absence of additional carbon source, with 85% of ciprofloxacin removed under sulfate-reducing conditions and 62% and 83% of ciprofloxacin and estradiol removed, respectively, under nitrate-reducing conditions.	Nitrates	245-252	N-acylsphingosine amidohydrolase 1	Homo sapiens	19-22
30010841-6	2018	Redundancy analysis identified positive correlations of nitrate, Escherichia coli, and coliforms with tet(W) and intI1 genes in sediment and intI1, sul1 and tet(W) genes in water.	Nitrates	56-63	IntI1	Escherichia coli	113-118
29957358-1	2018	This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0.	Nitrates	101-108	cytochrome c, somatic	Equus caballus	173-185
29957358-1	2018	This paper evaluates the effect of various lyotropic anions (chloride, sulfate, perchlorate, iodide, nitrate, bromide) on the thermodynamic stability and dynamics of native cytochrome c (Cyt c) at pH 7.0.	Nitrates	101-108	cytochrome c, somatic	Equus caballus	187-192
29777853-7	2018	Vitellogenin concentrations were slightly elevated in males (but not females) in all of the groups exposed to nitrate.	Nitrates	110-117	vitellogenin	Danio rerio	0-12
30111737-0	2018	Variations in Dissolved Nitrate, Chloride, and Sulfate in Precipitation, Reservoir, and Tap Waters, Columbus, Ohio.	Nitrates	24-31	nuclear RNA export factor 1	Homo sapiens	88-91
30099933-1	2018	BACKGROUND:: Ingestion of nitrate (NO3-)-containing vegetables, alcohol and polyphenols, separately, can reduce blood pressure (BP).	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
29998683-6	2018	Nitrate on the resin could be completely biodegraded within 10 h when the inoculum amount (measured as VSS) was higher than 0.6 g L-1.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	130-133
30040397-2	2018	Density functional theory (B3LYP) and relativistic multireference (CASPT2) calculations confirmed the AnO2(NO3)2- as AnVO2+ actinyl moieties coordinated by nitrates.	Nitrates	156-164	anoctamin 2	Homo sapiens	102-106
30040397-2	2018	Density functional theory (B3LYP) and relativistic multireference (CASPT2) calculations confirmed the AnO2(NO3)2- as AnVO2+ actinyl moieties coordinated by nitrates.	Nitrates	156-164	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
30310628-0	2018	The coordination chemistry of CmIII, AmIII, and AcIII in nitrate solutions: an actinide L3-edge EXAFS study.	Nitrates	57-64	adenylate cyclase 3	Homo sapiens	48-53
30131697-9	2018	The endothelial nitric oxide synthase (eNOS) protein and myocardial nitrate/nitrite were impaired in the heart of diabetic rats, which, however, were restored after PKK treatment.	Nitrates	68-75	kallikrein 1-related peptidase B3	Rattus norvegicus	165-168
29931366-1	2018	Campylobacter jejuni, a human gastrointestinal pathogen, uses nitrate for growth under microaerophilic conditions using periplasmic nitrate reductase (Nap).	Nitrates	62-69	catenin beta like 1	Homo sapiens	151-154
29704850-7	2018	The NH4+/NO3- experiment result demonstrated that ammonia and nitrate did convert into N2 during SCWO, however, the formation of N2 was little without auxiliary fuel.	Nitrates	62-69	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
30082037-1	2018	Agricultural contamination of groundwater with nitrate (NO3-) is one of the most widespread and pressing environmental issues.	Nitrates	47-54	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
29524892-1	2018	The feasibility of using Feammox coupled with nitrate-dependent Fe(II) oxidizing (NAFO) to cause the simultaneous conversion of NH4+ and NO3- was explored by inoculation with Feammox sludge and the use Fe cycling as catalyst.	Nitrates	46-53	NBL1, DAN family BMP antagonist	Homo sapiens	137-140
29722627-9	2018	Deoxygenated [hemoglobin + myoglobin] was not different for 40% peak ( P > 0.05) but was elevated throughout 85% peak ( P < 0.05) after nitrate.	Nitrates	136-143	myoglobin	Homo sapiens	27-36
29864505-4	2018	Additionally, since NO bioavailability can be improved with exogenous nitrate (NO3-) via the nitrate-nitrite-NO pathway, we tested the hypothesis that inorganic NO3- supplementation would reduce BP responses to muscle metaboreflex activation in healthy older adults.	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
29864505-4	2018	Additionally, since NO bioavailability can be improved with exogenous nitrate (NO3-) via the nitrate-nitrite-NO pathway, we tested the hypothesis that inorganic NO3- supplementation would reduce BP responses to muscle metaboreflex activation in healthy older adults.	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	161-164
29533800-2	2018	Nonetheless, in the freshwater-saltwater interface of endorheic saline lakes, oxidation-reduction (redox) reactions can attenuate pollutants such as nitrate (NO3-).	Nitrates	149-156	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
29802192-9	2018	The balance between internally and externally available electron acceptors (nitrate) and electron donors (reduced sulfur) likely controlled the end product of nitrate reduction both between orange and white FLSB mats and between different spatial and geochemical niches within the white FLSB mat.IMPORTANCE Whether large sulfur bacteria of the family Beggiatoaceae reduce NO3 - to N2 via denitrification or to NH4 + via DNRA has been debated in the literature for more than 25 years.	Nitrates	159-166	NBL1, DAN family BMP antagonist	Homo sapiens	372-375
29431644-1	2018	BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS).	Nitrates	12-20	prostaglandin I2 synthase	Homo sapiens	166-191
29431644-1	2018	BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS).	Nitrates	12-20	prostaglandin I2 synthase	Homo sapiens	193-198
29431644-1	2018	BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS).	Nitrates	117-124	prostaglandin I2 synthase	Homo sapiens	166-191
29431644-1	2018	BACKGROUND: Nitrates are widely used to treat coronary artery disease, but their therapeutic value is compromised by nitrate tolerance, because of the dysfunction of prostaglandin I2 synthase (PTGIS).	Nitrates	117-124	prostaglandin I2 synthase	Homo sapiens	193-198
29431644-3	2018	The aim of this study was to determine whether nitrates induce nitrovasodilator resistance via microRNA-dependent repression of PTGIS gene expression.	Nitrates	47-55	prostaglandin I2 synthase	Homo sapiens	128-133
30042774-4	2018	AtNPF6.3 has traditionally been characterized as a dual-affinity nitrate transporter contributing to root nitrate uptake in Arabidopsis.	Nitrates	65-72	nitrate transporter 1.1	Arabidopsis thaliana	0-8
30042774-5	2018	It has also been identified as a nitrate sensor which regulates the expression of high-affinity nitrate transport proteins NRT2s and lateral root development as a part of the primary nitrate response in plants.	Nitrates	33-40	nitrate transporter 2:1	Arabidopsis thaliana	123-127
30042774-5	2018	It has also been identified as a nitrate sensor which regulates the expression of high-affinity nitrate transport proteins NRT2s and lateral root development as a part of the primary nitrate response in plants.	Nitrates	96-103	nitrate transporter 2:1	Arabidopsis thaliana	123-127
30042774-9	2018	The review will investigate from a structural point of view how NPF6.3-like proteins may transport nitrate as well as other ions and what can be learned from structural uniqueness about predicted activities in plants.	Nitrates	99-106	nitrate transporter 1.1	Arabidopsis thaliana	64-70
29514014-6	2018	In the base condition, the PM2.5 mass concentrations were found to increase 15% from the background, whereas the nitrate (NO3-) content had a significant increase at the campus site.	Nitrates	113-120	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
29736649-2	2018	The nitrite and nitrate in drinking water had a concentration range of 0.030-0.113 and 2.41-8.70 mg L-1, with mean values of 0.059 +- 0.014 and 5.25 +- 1.61 mg L-1, respectively.	Nitrates	16-23	immunoglobulin kappa variable 1-16	Homo sapiens	100-103
29702279-12	2018	HO-1 played important roles in the down-regulation of superoxide levels in lung tissues by cordycepin, and HO-1 expression induced by cordycepin affected nitrite and nitrate concentrations in plasma and iNOS protein expression in lung tissues.	Nitrates	166-173	heme oxygenase 1	Rattus norvegicus	107-111
29785845-1	2018	This work demonstrates bromate (BrO3-) reduction in a methane (CH4)-based membrane biofilm reactor (MBfR), and it documents contrasting impacts of nitrate (NO3-) on BrO3- reduction, as well as formation of poly-beta-hydroxybutyrate (PHB), an internal C- and electron-storage material.	Nitrates	147-154	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
29534920-9	2018	TGF-beta correlated directly with nitrite and nitrate and inversely to other inflammatory factors.	Nitrates	46-53	transforming growth factor beta 1	Homo sapiens	0-8
29973922-15	2018	A flavin-based electron confurcating (FBEC) HdrABC complex is proposed for nitrate-dependent reverse methanogenesis in which the oxidation of CoM-SH/CoB-SH and Fdx2- is coupled to reduction of F420.	Nitrates	75-82	ferredoxin 2	Homo sapiens	160-164
29550729-1	2018	Denitrifying enhanced biological phosphorus removal (EBPR) systems can be an efficient means of removing phosphate (P) and nitrate (NO3-) with low carbon source and oxygen requirements.	Nitrates	123-130	NBL1, DAN family BMP antagonist	Homo sapiens	132-135
29676902-4	2018	An exception might be represented by the cases (rather rare in paddies) of quite high nitrate concentration (around 50 mg of NO3- L-1), when DCA degradation by CO3 - would play a comparable role to that by direct photolysis.	Nitrates	86-93	NBL1, DAN family BMP antagonist	Homo sapiens	125-128
28593806-2	2018	DHS-USB systems can perform nitrification and denitrification simultaneously, reducing ammonia (NH3) and nitrate (NO3-) toxicity in the water.	Nitrates	105-112	NBL1, DAN family BMP antagonist	Homo sapiens	114-117
29541882-5	2018	Quantitative reverse transcription polymerase chain reaction analysis indicated high expression levels of the nitrate transporter genes, especially NRT2.1, which plays a major role in the high-affinity nitrate transport system in roots.	Nitrates	110-117	nitrate transporter 2:1	Arabidopsis thaliana	148-154
29860377-9	2018	This, according to the level of total soluble sugars, can be explained by the existence of a cross-talk between the sugars in excess and low nitrate in the medium that blocks the activity of nitrate reductase in stressful sugar conditions until the plant is adapted to the stress.	Nitrates	141-148	nitrate reductase 1	Arabidopsis thaliana	191-208
29875779-2	2018	Although ammonium (NH4+) is the main N source for rice, nitrate (NO3-) is also absorbed and utilized.	Nitrates	56-63	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
29938022-3	2018	Experimental investigations, supported by electronic structure calculations, reveal that catalysis commences when nitrate binds to the two-electron reduced species CoII(DIM-), where cobalt and the macrocycle are each reduced by a single electron.	Nitrates	114-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	164-168
29563255-4	2018	Cav-1 small interfering RNA (siRNA) reduced eNOS protein and gene expression in association with a twofold increase in eNOS phosphorylation and nitrate production per molecule of eNOS, which was reversed in cells overexpressing Adv-Cav-1-GFP.	Nitrates	144-151	caveolin 1	Homo sapiens	0-5
29706511-0	2018	A Tandem Amino Acid Residue Motif in Guard Cell SLAC1 Anion Channel of Grasses Allows for the Control of Stomatal Aperture by Nitrate.	Nitrates	126-133	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	48-53
29748645-7	2018	The network analysis also identified HUB transcription factors like mTERF, FHA, Orphan, bZip and FAR1, which may be the key regulators of nitrate-mediated response in B. juncea.	Nitrates	138-145	tripartite motif-containing 17	Mus musculus	68-73
29706511-10	2018	When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel.	Nitrates	18-25	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	56-61
29706511-10	2018	When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel.	Nitrates	18-25	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	101-108
29706511-10	2018	When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel.	Nitrates	142-149	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	56-61
29706511-10	2018	When the motif of nitrate-insensitive dicot Arabidopsis SLAC1 was replaced by the monocot signature, AtSLAC1 converted into a grass-type like nitrate-sensitive channel.	Nitrates	142-149	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	101-108
29732470-3	2018	This study aimed to improve nitrate (NO3) load estimates using high-resolution records (15-min time interval) from optical sensors to capture the typical concentration response to storm events.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
29780398-0	2018	FIP1 Plays an Important Role in Nitrate Signaling and Regulates CIPK8 and CIPK23 Expression in Arabidopsis.	Nitrates	32-39	FH interacting protein 1	Arabidopsis thaliana	0-4
29965503-3	2018	It was shown that nitrogen pollution, which was dominated by nitrate (NO3-), existed in the four reservoirs.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
29780398-3	2018	Here, we report that the FIP1 gene (factor interacting with poly(A) polymerase 1) plays an important role in nitrate signaling in Arabidopsis thaliana.	Nitrates	109-116	FH interacting protein 1	Arabidopsis thaliana	25-29
29780398-5	2018	We found that FIP1 interacts with the cleavage and polyadenylation specificity factor 30-L (CPSF30-L), which is also an essential player in nitrate signaling.	Nitrates	140-147	FH interacting protein 1	Arabidopsis thaliana	14-18
29780398-5	2018	We found that FIP1 interacts with the cleavage and polyadenylation specificity factor 30-L (CPSF30-L), which is also an essential player in nitrate signaling.	Nitrates	140-147	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	92-98
29780398-6	2018	The induction of nitrate-responsive genes following nitrate treatment was inhibited in the fip1 mutant.	Nitrates	17-24	FH interacting protein 1	Arabidopsis thaliana	91-95
29780398-6	2018	The induction of nitrate-responsive genes following nitrate treatment was inhibited in the fip1 mutant.	Nitrates	52-59	FH interacting protein 1	Arabidopsis thaliana	91-95
29780398-7	2018	The nitrate content was also reduced in fip1 seedlings due to their decreased nitrate uptake activity.	Nitrates	4-11	FH interacting protein 1	Arabidopsis thaliana	40-44
29780398-7	2018	The nitrate content was also reduced in fip1 seedlings due to their decreased nitrate uptake activity.	Nitrates	78-85	FH interacting protein 1	Arabidopsis thaliana	40-44
29780398-8	2018	Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes.	Nitrates	17-24	FH interacting protein 1	Arabidopsis thaliana	83-87
29780398-8	2018	Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes.	Nitrates	17-24	NITRATE TRANSPORTER 1.8	Arabidopsis thaliana	133-139
29780398-8	2018	Furthermore, the nitrate content was higher in the roots but lower in the roots of fip1, which may result from the downregulation of NRT1.8 and the upregulation of the nitrate assimilation genes.	Nitrates	168-175	FH interacting protein 1	Arabidopsis thaliana	83-87
29780398-9	2018	In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling.	Nitrates	135-142	FH interacting protein 1	Arabidopsis thaliana	41-45
29780398-9	2018	In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling.	Nitrates	135-142	CBL-interacting protein kinase 8	Arabidopsis thaliana	85-90
29780398-9	2018	In addition, qPCR analyses revealed that FIP1 negatively regulated the expression of CIPK8 and CIPK23, two protein kinases involved in nitrate signaling.	Nitrates	135-142	CBL-interacting protein kinase 23	Arabidopsis thaliana	95-101
29780398-10	2018	In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content.	Nitrates	66-73	FH interacting protein 1	Arabidopsis thaliana	7-11
29780398-10	2018	In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content.	Nitrates	66-73	CBL-interacting protein kinase 23	Arabidopsis thaliana	48-54
29780398-10	2018	In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content.	Nitrates	105-112	FH interacting protein 1	Arabidopsis thaliana	7-11
29780398-10	2018	In the fip1 mutant, the increased expression of CIPK23 may affect nitrate uptake, resulting in its lower nitrate content.	Nitrates	105-112	CBL-interacting protein kinase 23	Arabidopsis thaliana	48-54
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	FH interacting protein 1	Arabidopsis thaliana	45-49
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	54-60
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	FH interacting protein 1	Arabidopsis thaliana	116-120
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	170-176
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	CBL-interacting protein kinase 8	Arabidopsis thaliana	201-206
29780398-11	2018	Genetic and molecular evidence suggests that FIP1 and CPSF30-L function in the same nitrate-signaling pathway, with FIP1 mediating signaling through its interaction with CPSF30-L and its regulation of CIPK8 and CIPK23.	Nitrates	84-91	CBL-interacting protein kinase 23	Arabidopsis thaliana	211-217
29432804-11	2018	RESULTS: Nitrate supplementation in diabetic rats significantly improved glucose tolerance, lipid profiles, and catalase activity as well as decreased gluconeogenesis, fasting glucose, insulin, and IL-1beta; although it had no significant effect on GSIS, islet insulin content, HbA1c, and serum TBARS.	Nitrates	9-16	interleukin 1 beta	Rattus norvegicus	198-206
29428615-5	2018	NO3- (from HPAM oxidation) as electron acceptors stimulated the activities of nitrate-reducing, acetate-producing and methanogenic microorganisms and they could form a synergistic effect on denitrification and methanogenesis.	Nitrates	78-85	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
29795728-1	2018	Dietary nitrate (NO3-) has been shown to reduce oxygen consumption (VO2) during moderate to high-intensity (e.g. time to fatigue, time trials) exercise and often in trained athletes.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29378248-2	2018	Mice with a NOS1 knockout have markedly reduced muscle nitrate levels, suggesting NO production by NOS and its reaction with oxymyoglobin as a source of nitrate.	Nitrates	55-62	nitric oxide synthase 1, neuronal	Mus musculus	12-16
29378248-2	2018	Mice with a NOS1 knockout have markedly reduced muscle nitrate levels, suggesting NO production by NOS and its reaction with oxymyoglobin as a source of nitrate.	Nitrates	153-160	nitric oxide synthase 1, neuronal	Mus musculus	12-16
29432804-13	2018	In diabetic rats, nitrate administration increased GLUT4 mRNA expression and protein levels in both soleus muscle (215% and 17%, respectively) and epididymal adipose tissue (344% and 22%, respectively).	Nitrates	18-25	solute carrier family 2 member 4	Rattus norvegicus	51-56
29432804-14	2018	In diabetic rats, nitrate significantly decreased elevated iNOS mRNA expression in both the soleus muscle and epididymal adipose tissue.	Nitrates	18-25	nitric oxide synthase 2	Rattus norvegicus	59-63
29432804-15	2018	CONCLUSION: Chronic nitrate supplementation in obese type 2 diabetic rats improved glucose tolerance, insulin resistance, and dyslipidemia; these favorable effects were associated with increased mRNA and protein expression of GLUT4 and decreased mRNA expression of iNOS in insulin-sensitive tissues, and with decreased gluconeogenesis, inflammation, and oxidative stress.	Nitrates	20-27	solute carrier family 2 member 4	Rattus norvegicus	226-231
29432804-15	2018	CONCLUSION: Chronic nitrate supplementation in obese type 2 diabetic rats improved glucose tolerance, insulin resistance, and dyslipidemia; these favorable effects were associated with increased mRNA and protein expression of GLUT4 and decreased mRNA expression of iNOS in insulin-sensitive tissues, and with decreased gluconeogenesis, inflammation, and oxidative stress.	Nitrates	20-27	nitric oxide synthase 2	Rattus norvegicus	265-269
30428377-0	2018	Adaptive Regulation of Nitrate Transceptor NRT1.1 in Fluctuating Soil Nitrate Conditions.	Nitrates	23-30	immunoglobulin superfamily member 9	Homo sapiens	43-47
29570365-6	2018	In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency.	Nitrates	58-65	immunoglobulin superfamily member 9	Homo sapiens	41-45
29570365-6	2018	In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency.	Nitrates	77-84	immunoglobulin superfamily member 9	Homo sapiens	41-45
29570365-6	2018	In this review, we focus on the roles of NRT1 and NRT2 in nitrate uptake and nitrate allocation among different tissues; we describe the functions of the transceptor NRT1.1, transcription factors, and small signaling peptides in nitrate signaling and tissue communication; and we compile the new strategies for improving nitrogen-use efficiency.	Nitrates	77-84	immunoglobulin superfamily member 9	Homo sapiens	41-45
30428377-0	2018	Adaptive Regulation of Nitrate Transceptor NRT1.1 in Fluctuating Soil Nitrate Conditions.	Nitrates	70-77	immunoglobulin superfamily member 9	Homo sapiens	43-47
30428377-3	2018	It has recently been reported that many of these responses are regulated by a transceptor NRT1.1, a transporter cum receptor of nitrate signaling.	Nitrates	128-135	immunoglobulin superfamily member 9	Homo sapiens	90-94
30428377-4	2018	NRT1.1 displays dual-affinity modes of nitrate binding and establishes phosphorylated/non-phosphorylated states at the amino acid residue threonine 101 in response to fluctuating nitrate concentrations.	Nitrates	39-46	immunoglobulin superfamily member 9	Homo sapiens	0-4
30428377-4	2018	NRT1.1 displays dual-affinity modes of nitrate binding and establishes phosphorylated/non-phosphorylated states at the amino acid residue threonine 101 in response to fluctuating nitrate concentrations.	Nitrates	179-186	immunoglobulin superfamily member 9	Homo sapiens	0-4
30428377-5	2018	Here we report that intrinsic structural asymmetries between the protomers of the homodimer NRT1.1 provide a functional basis for having dual-affinity modes of nitrate binding and play a pivotal role for the phosphorylation switch.	Nitrates	160-167	immunoglobulin superfamily member 9	Homo sapiens	92-96
31020121-4	2018	Coronary angiography revealed focal coronary vasospasm in the proximal LCx, well responsive for intracoronary nitrates.	Nitrates	110-118	tet methylcytosine dioxygenase 1	Homo sapiens	71-74
29376168-6	2018	Relationships between Hg variables and ancillary biogeochemistry suggest that Hg methylation is carried out by sulfate reducing bacteria, but that the process is modulated by the supply of IHg substrate, sediment total and labile organic carbon, and possibly competition with nitrate reducers.	Nitrates	276-283	IHG1	Homo sapiens	189-192
29438701-8	2018	SL-CLP enhanced nitrate/nitrite (NOx) concentrations in the MAB of WT, but not iNOS-deficient mice.	Nitrates	16-23	leucine-rich repeat LGI family, member 4	Mus musculus	3-6
29427942-5	2018	In E25 release, nitrate reduction was largely responsible for BTEX and ethanol biodegradation, as intended.	Nitrates	16-23	integral membrane protein 2C	Homo sapiens	3-6
29649183-4	2018	Gene expression ratios of nitrate vs. the control were highly enhanced for those probesets related to nitrate transport and assimilation and carbon metabolism in the roots, but much less so in the nodules, except for the nitrate transport and asparagine synthetase.	Nitrates	26-33	asparagine synthetase	Glycine max	243-264
29662028-6	2018	Nitrate did not affect the subcellular localization of the NRs, but it caused AtSIZ1 to move from the nucleus to the cytoplasm.	Nitrates	0-7	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	78-84
29636481-4	2018	Here we identify NIGT1 transcriptional repressors as negative regulators of the Arabidopsis NRT2.1 nitrate transporter gene, and show antagonistic regulation by NLP primary transcription factors for nitrate signalling and the NLP-NIGT1 transcriptional cascade-mediated repression.	Nitrates	99-106	nitrate transporter 2:1	Arabidopsis thaliana	92-98
29636481-6	2018	Genome-wide analysis reveals that this mechanism is applicable to NRT2.1 and other genes involved in nitrate assimilation, hormone biosynthesis and transcription.	Nitrates	101-108	nitrate transporter 2:1	Arabidopsis thaliana	66-72
29636481-7	2018	Furthermore, the PHR1 master regulator of the phosphorus-starvation response also directly promotes expression of NIGT1 family genes, leading to reductions in nitrate uptake.	Nitrates	159-166	photolyase 1	Arabidopsis thaliana	17-21
29964983-2	2018	Results show that the nitrate concentrations range from 0.46 to 18.48 mg L-1, with an average of 6.18 mg L-1, and that the nitrate levels are low during the dry season.	Nitrates	22-29	immunoglobulin kappa variable 1-16	Homo sapiens	73-76
29964983-2	2018	Results show that the nitrate concentrations range from 0.46 to 18.48 mg L-1, with an average of 6.18 mg L-1, and that the nitrate levels are low during the dry season.	Nitrates	22-29	immunoglobulin kappa variable 1-16	Homo sapiens	105-108
29516298-3	2018	Taking advantage of the capacity of cytochrome c (cyt c) to bind anions on its protein surface, the commercially available bCyt c was crystallized without extra purifications, using ammonium sulfate as precipitant and nitrate ions as additives.	Nitrates	218-225	LOC104968582	Bos taurus	50-55
29510032-1	2018	The main objective of this study is to examine how the charge densities of four monovalent anions-fluoride (F-), chloride (Cl-), bromide (Br-), and nitrate (NO3-)-influence their Donnan (charge) exclusion by a charged nanofiltration (NF) membrane.	Nitrates	148-155	NBL1, DAN family BMP antagonist	Homo sapiens	157-160
29175273-4	2018	The results showed that the proposed system removes 800mgL-1 nitrate up to 95% during 6.5h.	Nitrates	61-68	LLGL scribble cell polarity complex component 1	Homo sapiens	55-60
29175692-2	2018	In this paper, we attempt to give a theoretical interpretation of sulfate/nitrate reducing bacteria (SRB/NRB)-assisted cracking using Ee-pH diagrams.	Nitrates	74-81	chaperonin containing TCP1 subunit 4	Homo sapiens	101-104
29175692-5	2018	Nitrate is a far more potent oxidant than sulfate, and thus, the NRB-assisted cracking of iron is a more thermodynamically favorable process than the SRB-assisted cracking.	Nitrates	0-7	chaperonin containing TCP1 subunit 4	Homo sapiens	150-153
29334654-4	2018	Results indicated that an average nitrate removal efficiency of 99% could be achieved with an influent NO3--N concentration of 100 mg L-1 and a hydraulic retention time (HRT) of 7.25 h. Mass balance model predicted that 80% of the PHBV polymers were consumed by denitrifying bacteria, close to 72% consumption in real condition, suggesting the model might be useful for PHBV polymers management in BPD system.	Nitrates	34-41	immunoglobulin kappa variable 1-16	Homo sapiens	134-137
29392604-1	2018	Seepage faces, the outer rim of subterranean estuaries, are an important reaction node for SGD-borne nitrate (NO3-) on a global scale.	Nitrates	101-108	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
29407609-7	2018	Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s).	Nitrates	10-17	uncharacterized protein	Chlamydomonas reinhardtii	51-55
29407609-7	2018	Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s).	Nitrates	10-17	uncharacterized protein	Chlamydomonas reinhardtii	91-95
29407609-7	2018	Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s).	Nitrates	10-17	uncharacterized protein	Chlamydomonas reinhardtii	177-181
29407609-7	2018	Moreover, nitrate assimilation regulatory protein (NIT2) is involved in the control of the AOX1 gene expression in the absence of S. Together, the results clearly indicate that AOX1 relates to S limitation stress responses and is regulated in a NIT2-dependent manner, probably together with yet-unknown regulatory factor(s).	Nitrates	10-17	uncharacterized protein	Chlamydomonas reinhardtii	245-249
29762848-11	2018	CXCR3 siRNA significantly reduced nitrate level in chondrocytes induced by IL-beta (35.22 +- 1.76 vs. 17.82 +- 0.89, p&lt;0.05) without affecting cell apoptosis (1.13 +- 0.05 vs. 0.859 +- 0.04, p&gt;0.05).	Nitrates	34-41	C-X-C motif chemokine receptor 3	Homo sapiens	0-5
29762848-12	2018	CXCR3 siRNA markedly downregulated nitrate level in chondrocytes (50.63 +- 2.53 vs. 30.63 +- 1.63, p&lt;0.05) and alleviated cell apoptosis induced by SNP (1.98 +- 0.10 vs. 1.25 +- 0.06, p&lt;0.05).	Nitrates	35-42	C-X-C motif chemokine receptor 3	Homo sapiens	0-5
29680555-2	2018	Average values of nitrate (NO3-), dissolved silica (DSi) and phosphate (PO43-) is 2.09 mg/l, 12.7 mg/l and 0.16 mg/l in wet season and 0.47 mg/l, 6.96 mg/l and 0.29 mg/l in dry season respectively.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
29736108-6	2018	Treatment with nitrates calcium, calcium channel blockers and antiplatelet in the basis of ACS is highly indicated.	Nitrates	15-23	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	91-94
29356324-0	2018	Kinetic Analysis and Structural Interpretation of Competitive Ligand Binding for NO Dioxygenation in Truncated Hemoglobin N. The conversion of nitric oxide (NO) into nitrate (NO3- ) by dioxygenation protects cells from lethal NO.	Nitrates	166-173	NBL1, DAN family BMP antagonist	Homo sapiens	175-178
29358221-0	2018	Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance.	Nitrates	174-181	aldehyde dehydrogenase 2 family member	Homo sapiens	61-85
29358221-1	2018	According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols.	Nitrates	92-99	aldehyde dehydrogenase 2 family member	Homo sapiens	41-65
29358221-1	2018	According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols.	Nitrates	92-99	aldehyde dehydrogenase 2 family member	Homo sapiens	67-72
29540568-4	2018	While nitrate (NO3-) is a major N form used by plants worldwide, it is discounted as a N source for Arctic tundra plants because of extremely low NO3- concentrations in Arctic tundra soils, undetectable soil nitrification, and plant-tissue NO3- that is typically below detection limits.	Nitrates	6-13	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
29540568-6	2018	Nitrate assimilation determined by 15N enrichments of leaf NO3- relative to soil NO3- accounted for 4 to 52% (as estimated by a Bayesian isotope-mixing model) of species-specific total leaf N of Alaskan tundra plants.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
29540568-6	2018	Nitrate assimilation determined by 15N enrichments of leaf NO3- relative to soil NO3- accounted for 4 to 52% (as estimated by a Bayesian isotope-mixing model) of species-specific total leaf N of Alaskan tundra plants.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
29555906-3	2018	Here we find that N2O flux can be predicted by models incorporating soil nitrate concentration (NO3-), water content and temperature using a global field survey of N2O emissions and potential driving factors across a wide range of organic soils.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	96-99
29281085-10	2018	Whether these proteases play a back-up role in nutrient recycling and remobilization in atg mutants or act to promote cell death is discussed in relation to their accumulation patterns in the atg5 mutant compared with the salicylic acid-depleted atg5/sid2 double-mutant, and in low nitrate compared with high nitrate conditions.	Nitrates	282-289	autophagy protein Apg5 family	Arabidopsis thaliana	192-196
29126024-4	2018	The delta15N-NO3- and delta34S-SO42- values were more enriched by approximately 37% and 15% in the LPS than the overlying HPS associated with substantial reductions of the NO3- and SO42- concentration, indicating the occurrence of strong bio-reductions in nitrate and sulfate.	Nitrates	256-263	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
29281085-10	2018	Whether these proteases play a back-up role in nutrient recycling and remobilization in atg mutants or act to promote cell death is discussed in relation to their accumulation patterns in the atg5 mutant compared with the salicylic acid-depleted atg5/sid2 double-mutant, and in low nitrate compared with high nitrate conditions.	Nitrates	309-316	autophagy protein Apg5 family	Arabidopsis thaliana	192-196
29518046-8	2018	Co-expression-network analysis of TFs with closely related profiles to known Nitrate-responsive genes identified GLK5, GLK8 and NLP15 as candidate regulators of genes repressed under low Nitrogen conditions, while bZIP108 might play a role in gene activation.	Nitrates	77-84	Transcription factor NIGT1	Zea mays	113-117
29965484-9	2018	The nitrate reduction bacteria were Pseudomonas and Clostridia when the nitrate concentration was 200 mg L-1.	Nitrates	4-11	immunoglobulin kappa variable 1-16	Homo sapiens	105-108
29965484-9	2018	The nitrate reduction bacteria were Pseudomonas and Clostridia when the nitrate concentration was 200 mg L-1.	Nitrates	72-79	immunoglobulin kappa variable 1-16	Homo sapiens	105-108
29965484-10	2018	The Pseudomonas and Thermomonas emerged when the nitrate concentration increased to 500 mg L-1, and the rate of methane conversion was increased by 34.7%.	Nitrates	49-56	immunoglobulin kappa variable 1-16	Homo sapiens	91-94
29518046-8	2018	Co-expression-network analysis of TFs with closely related profiles to known Nitrate-responsive genes identified GLK5, GLK8 and NLP15 as candidate regulators of genes repressed under low Nitrogen conditions, while bZIP108 might play a role in gene activation.	Nitrates	77-84	uncharacterized LOC100191786	Zea mays	214-221
29443517-4	2018	Addition of nitrate with the Lewis acid Sc(OTf)3 (OTf = trifluoromethanesulfonate) to 2 results in an immediate and clean conversion of 2 to MoVI(O)2(SN)2 (1).	Nitrates	12-19	POU class 5 homeobox 1	Homo sapiens	40-48
29513738-1	2018	Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter.	Nitrates	171-179	hemoglobin subunit gamma 2	Homo sapiens	127-140
29513738-1	2018	Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter.	Nitrates	171-179	hemoglobin subunit gamma 2	Homo sapiens	142-147
29553034-1	2018	Nitrate (NO3 -) is an ergogenic nutritional supplement that is widely used to improve physical performance.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
29360963-3	2018	Nitrite initially accumulated in all three soils; its subsequent decline or slowing of the accumulation of the NO2- pool by 24 h was accompanied by an increase in the size of the nitrate (NO3-) pool, indicating a change in NO2- oxidation kinetics.	Nitrates	179-186	NBL1, DAN family BMP antagonist	Homo sapiens	188-191
29306125-6	2018	The increased NO3--N/SCN--N ratio in the treated wastewater resulted in the decreased removal efficiency of nitrate, and the increased nitrate-to-nitrite transformation ratio and the ratio of NO2--N to NH4+-N.	Nitrates	108-115	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
29306125-6	2018	The increased NO3--N/SCN--N ratio in the treated wastewater resulted in the decreased removal efficiency of nitrate, and the increased nitrate-to-nitrite transformation ratio and the ratio of NO2--N to NH4+-N.	Nitrates	135-142	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
29348067-3	2018	NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX).	Nitrates	37-44	peroxidase	Solanum lycopersicum	240-243
29348067-3	2018	NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX).	Nitrates	37-44	catalase isozyme 1	Solanum lycopersicum	246-254
29348067-3	2018	NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX).	Nitrates	37-44	catalase isozyme 1	Solanum lycopersicum	256-259
29348067-3	2018	NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX).	Nitrates	37-44	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	262-282
29348067-3	2018	NaHS altered the oxidative status of nitrate-stressed plants as inferred by changes in reactive oxygen species (ROS) accumulation and lipid peroxidation accompanied by regulation of the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX).	Nitrates	37-44	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	284-287
29492096-1	2018	Background: Considering the lack of data on the association between habitual dietary intakes of nitrate (NO3-) and nitrite (NO2-) and cardiovascular events, we assessed possible effects of dietary NO3- and NO2-, in the context of total antioxidant capacity (TAC) of the diet, with the risk of cardiovascular (CVD) outcomes.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
29211505-4	2018	Dietary nitrate (NO3-) supplementation has been shown to lower the O2 consumption in various conditions.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29432741-9	2018	Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis.	Nitrates	115-122	DNA nucleotidylexotransferase	Rattus norvegicus	0-37
29248688-6	2018	Under optimum conditions, the limits of detection in the original solutions were 0.49 mug L-1 and 0.40 mug L-1 for nitrate and nitrite, respectively.	Nitrates	115-122	immunoglobulin kappa variable 1-16	Homo sapiens	90-93
29248688-6	2018	Under optimum conditions, the limits of detection in the original solutions were 0.49 mug L-1 and 0.40 mug L-1 for nitrate and nitrite, respectively.	Nitrates	115-122	immunoglobulin kappa variable 1-16	Homo sapiens	107-110
29432741-9	2018	Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis.	Nitrates	115-122	caspase 3	Rattus norvegicus	73-82
29432741-9	2018	Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis.	Nitrates	115-122	superoxide dismutase 1	Rattus norvegicus	193-219
29432741-9	2018	Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and caspase-3 expression analyses showed that nitrate also protected cells from apoptosis, possibly through upregulation of Cu-Zn superoxide dismutase (Cu-Zn SOD) known to inhibit oxidative stress-related apoptosis.	Nitrates	115-122	superoxide dismutase 1	Rattus norvegicus	221-230
29432741-10	2018	Our findings indicate that nitrate could improve functional activity of the salivary glands in OVX rats by suppressing apoptosis and upregulating Cu-Zn SOD expression, suggesting that dietary nitrate may potentially prevent hyposalivation in menopausal women.	Nitrates	27-34	superoxide dismutase 1	Rattus norvegicus	146-155
29432741-10	2018	Our findings indicate that nitrate could improve functional activity of the salivary glands in OVX rats by suppressing apoptosis and upregulating Cu-Zn SOD expression, suggesting that dietary nitrate may potentially prevent hyposalivation in menopausal women.	Nitrates	192-199	superoxide dismutase 1	Rattus norvegicus	146-155
28992502-9	2018	Nitrate concentrations are generally low in the pristine headwaters (&lt;3mgL-1) and increase downstream (15 to 16mgL-1) due to the contribution of agricultural and wastewater sources.	Nitrates	0-7	LLGL scribble cell polarity complex component 1	Homo sapiens	74-79
28992502-9	2018	Nitrate concentrations are generally low in the pristine headwaters (&lt;3mgL-1) and increase downstream (15 to 16mgL-1) due to the contribution of agricultural and wastewater sources.	Nitrates	0-7	LLGL scribble cell polarity complex component 1	Homo sapiens	114-119
29159716-8	2018	MERA (100 mug/ml) inhibited total COX and 5-LOX activity at 50.53 and 62.03%, respectively, besides significantly (p &lt; 0.05) diminished nitrate and ROS generation, when compared with LPS control.	Nitrates	139-146	Era (G-protein)-like 1 (E. coli)	Mus musculus	0-4
29964852-6	2018	The concentrations of effluent nitrate were lower than 0.5 mg L-1, and the nitrite accumulation rates were higher than 99%.	Nitrates	31-38	immunoglobulin kappa variable 1-16	Homo sapiens	62-65
29876433-3	2018	The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively.	Nitrates	85-92	latexin	Homo sapiens	133-136
29876433-3	2018	The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively.	Nitrates	85-92	latexin	Homo sapiens	144-147
29876433-3	2018	The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively.	Nitrates	85-92	PWWP domain containing 3A, DNA repair factor	Homo sapiens	194-204
29876433-3	2018	The electrochemical data show that Cu nanowire arrays exhibited a linear response to nitrate ions over a concentration range from 50 muM to 600 muM (R2 = 0.9974) with a sensitivity of 0.357 muA muM-1 cm-1 and detection limit of 12.2 muM at a signal-to-noise ratio of 3, respectively.	Nitrates	85-92	latexin	Homo sapiens	144-147
28916479-2	2018	Dietary nitrate (NO3-), a source of nitric oxide (NO), has improved these measures in some studies of other populations.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
28562133-1	2018	Dietary nitrate (NO3-) supplementation has been associated with improved vascular and metabolic health.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
29450536-8	2018	Nitrate/nitrite levels in HLE cells showed a significant increase with 2% Cu-Ch treatment compared to CS.	Nitrates	0-7	elastase, neutrophil expressed	Homo sapiens	26-29
29362099-1	2018	Nitrate reductase (NR) mainly reduces nitrate to nitrite.	Nitrates	38-45	nitrate reductase [NADH]-like	Cucumis sativus	0-17
29362099-1	2018	Nitrate reductase (NR) mainly reduces nitrate to nitrite.	Nitrates	38-45	nitrate reductase [NADH]-like	Cucumis sativus	19-21
29362099-12	2018	Moreover, the increase of nitrite tissue level in short-term stressed roots and the nitrite/nitrate ratio, with a simultaneous decrease of nitrite reductase (NiR) activity, in both short- and long-term stressed roots, could promote the production of NO by NR in roots under salt stress.	Nitrates	92-99	nitrate reductase [NADH]-like	Cucumis sativus	256-258
29364528-7	2018	Ectopic expression of ZmNLP3.1 restored the N-deficient phenotypes of nlp7-1 under nitrate-replete conditions in terms of shoot biomass, root morphology and nitrate assimilation.	Nitrates	83-90	NIN like protein 7	Arabidopsis thaliana	70-74
29364528-8	2018	Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling.	Nitrates	17-24	nitrate transport 2	Zea mays	38-42
29364528-8	2018	Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling.	Nitrates	17-24	NIN like protein 7	Arabidopsis thaliana	112-116
29364528-8	2018	Furthermore, the nitrate induction of NRT2.1, NIA1, and NiR1 gene expression was recovered in the 35S::ZmNLP3.1/nlp7-1 transgenic lines, indicating that ZmNLP3.1 plays essential roles in nitrate signaling.	Nitrates	187-194	NIN like protein 7	Arabidopsis thaliana	112-116
29367694-0	2018	The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium.	Nitrates	36-43	NIN like protein 7	Arabidopsis thaliana	16-20
28843981-2	2018	With nitrate (NO3-) being the main form of N available to cereal crops there has been a significant global research effort to understand plant NO3- uptake.	Nitrates	5-12	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
29367694-0	2018	The Arabidopsis NLP7 gene regulates nitrate signaling via NRT1.1-dependent pathway in the presence of ammonium.	Nitrates	36-43	nitrate transporter 1.1	Arabidopsis thaliana	58-62
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	84-91	nitrate transporter 1.1	Arabidopsis thaliana	22-28
29367694-3	2018	In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7).	Nitrates	70-77	nitrate transporter 1.1	Arabidopsis thaliana	46-52
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	84-91	NIN like protein 7	Arabidopsis thaliana	32-36
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	119-126	nitrate transporter 1.1	Arabidopsis thaliana	22-28
29367694-3	2018	In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7).	Nitrates	70-77	nitrate transporter 1.1	Arabidopsis thaliana	116-120
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	119-126	NIN like protein 7	Arabidopsis thaliana	32-36
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	119-126	nitrate transporter 1.1	Arabidopsis thaliana	22-28
29367694-5	2018	Ectopic expression of NRT1.1 in nlp7 resulted in partial or complete restoration of nitrate signaling (expression from nitrate-regulated promoter NRP), nitrate content and nitrate reductase activity in the transgenic lines.	Nitrates	119-126	NIN like protein 7	Arabidopsis thaliana	32-36
29367694-8	2018	Thus, NLP7 acts as an important factor in nitrate signaling via regulating NRT1.1 under NH4+ conditions.	Nitrates	42-49	NIN like protein 7	Arabidopsis thaliana	6-10
29367694-8	2018	Thus, NLP7 acts as an important factor in nitrate signaling via regulating NRT1.1 under NH4+ conditions.	Nitrates	42-49	nitrate transporter 1.1	Arabidopsis thaliana	75-79
29367694-3	2018	In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7).	Nitrates	70-77	nitrate transporter 1.1	Arabidopsis thaliana	125-131
29367694-3	2018	In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7).	Nitrates	70-77	NIN like protein 7	Arabidopsis thaliana	150-168
29367694-3	2018	In this study, we show that the expression of NRT1.1, which encodes a nitrate sensor and transporter (also known as CHL1 and NPF6.3), is modulated by NIN-like protein 7 (NLP7).	Nitrates	70-77	NIN like protein 7	Arabidopsis thaliana	170-174
29367694-4	2018	Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1.	Nitrates	78-85	NIN like protein 7	Arabidopsis thaliana	45-49
29367694-4	2018	Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1.	Nitrates	78-85	nitrate transporter 1.1	Arabidopsis thaliana	68-74
29367694-4	2018	Genetic and molecular analyses indicate that NLP7 works upstream of NRT1.1 in nitrate regulation when NH4+ is present, while in absence of NH4+, it functions in nitrate signaling independently of NRT1.1.	Nitrates	161-168	NIN like protein 7	Arabidopsis thaliana	45-49
28886566-6	2018	Removal of 60mgL-1 NH4+-N was associated only with smaller amounts of nitrite build-up (~5mgL-1 NO2--N) and negligible nitrate concentrations.	Nitrates	119-126	LLGL scribble cell polarity complex component 1	Homo sapiens	13-18
29309650-0	2018	SMZ/SNZ and gibberellin signaling are required for nitrate-elicited delay of flowering time in Arabidopsis thaliana.	Nitrates	51-58	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-7
29309650-5	2018	We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate.	Nitrates	211-218	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	110-121
29309650-5	2018	We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate.	Nitrates	211-218	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	123-126
29309650-5	2018	We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate.	Nitrates	211-218	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	132-146
29309650-5	2018	We revealed that repressors of flowering time belonging to the AP2-type transcription factor family including SCHLAFMUTZE (SMZ) and SCHNARCHZAPFEN (SNZ) are important regulators of flowering time in response to nitrate.	Nitrates	211-218	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	148-151
29309650-6	2018	Our results support a model whereby nitrate activates SMZ and SNZ via the gibberellin pathway to repress flowering time in Arabidopsis thaliana.	Nitrates	36-43	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	54-57
29309650-6	2018	Our results support a model whereby nitrate activates SMZ and SNZ via the gibberellin pathway to repress flowering time in Arabidopsis thaliana.	Nitrates	36-43	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	62-65
29343715-5	2018	In this layer, the nitrate leaching values for T1 (13.76 kg ha-2) and T2 (13.74 kg ha-2) were both significantly lower than those of the control (15.76 kg ha-2) (P &lt; 0.05); the soil nitrate leaching losses decreased by 12.71% and 12.84% for those two treatments, respectively.	Nitrates	19-26	keratin 32	Homo sapiens	60-64
29324707-1	2018	Controlled release urea (CRU) is considered to enhance crop yields while alleviating negative environmental problems caused by the hazardous gas emissions that are associated with high concentrations of ammonium (NH4+) and nitrate (NO3-) in black soils.	Nitrates	223-230	NBL1, DAN family BMP antagonist	Homo sapiens	232-235
29070503-8	2018	Additionally, the training-induced change in cfPWV was negatively correlated with the training-induced change in serum adiponectin, CTRP3, and CTRP5 levels ( r = -0.51, r = -0.48, r = -0.42, respectively, P &lt; 0.05), and increased plasma nitrite/nitrate level by exercise training was correlated only with adiponectin levels ( r = 0.41, P &lt; 0.05).	Nitrates	248-255	adiponectin, C1Q and collagen domain containing	Homo sapiens	119-130
29526907-3	2018	The developed on-line PIEC ion stacking-ion chromatography method was validated by recovery experiments for the determination of nitrate in tap water in terms of both accuracy and precision, and the results showed the reliability of the method.	Nitrates	129-136	nuclear RNA export factor 1	Homo sapiens	140-143
29778214-3	2018	Recent attempts to characterize bacterial NOS (bNOS) have resulted in the discovery of structural features that may allow it to function as a NO dioxygenase and produce nitrate in addition to NO.	Nitrates	169-176	nitric oxide synthase 1	Homo sapiens	47-51
29778214-4	2018	Consistent with this characterization, investigations into the biological function of bNOS have also emphasized a role for NOS-dependent nitrate and nitrite production in aerobic and microaerobic respiration.	Nitrates	137-144	nitric oxide synthase 1	Homo sapiens	86-90
29166553-3	2018	Topical nitrates (TN) heal CAF effectively but recurrences are common.	Nitrates	8-16	lysine acetyltransferase 2B	Homo sapiens	27-30
29985754-4	2018	Nitrate levels were systematically high (&gt; 50 mg L-1 in a significant number of samples) and mean levels of trace elements were higher than the established values of Canadian Environmental Quality Guidelines for aquatic life protection for Al, Cu, Se, Ag, Cd and Pb in Douro and Ave, and also Zn in Ave.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	52-55
28942280-9	2018	Internal dosing of nitrate was confirmed by measuring plasma and urine nitrate levels and whole blood methemoglobin.	Nitrates	19-26	hemoglobin subunit gamma 2	Homo sapiens	102-115
29368802-2	2018	We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
29473797-5	2018	Among various antioxidants, Vit E reacted more effectively with many nitrosating agents such as nitrate and nitrite found in cosmetic products.	Nitrates	96-103	vitrin	Homo sapiens	28-31
28988245-1	2018	BACKGROUND/AIMS: 2-aminoethyl nitrate (CLC-1011) is a member of the class of organic nitrates that cause vasodilation by the generation of nitric oxide ( NO).	Nitrates	85-93	Charcot-Leyden crystal galectin	Homo sapiens	39-42
29380952-1	2018	Dietary nitrate (NO3-) is converted to nitrite (NO2-) and can be further reduced to the vasodilator nitric oxide (NO) amid a low O2 environment.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
28826121-5	2018	The major elements were all within the World Health Organization (WHO) guidelines for drinking water quality, except for nitrates in some wells, which was found at a concentration &gt;50mg NO3-/L.	Nitrates	121-129	NBL1, DAN family BMP antagonist	Homo sapiens	189-192
29304531-9	2018	Following nitrate supplementation, plasma RSNO was elevated (4.7 +- 0.8 vs 0.2 +- 0.5 nM) and thrombin-receptor mediated platelet aggregation was reduced (-19.9 +- 6.0 vs 4.0 +- 6.4 U) only in the clopidogrel group compared with placebo.	Nitrates	10-17	coagulation factor II, thrombin	Homo sapiens	94-102
29307111-6	2018	Daily nitrate intake (0.5 mmol L-1) restored nitrate levels, decreased ALT and AST levels, and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose (D-gal)-induced ageing mice (n=10) and in natural aged mice (n=10).	Nitrates	6-13	glutamic pyruvic transaminase, soluble	Mus musculus	71-74
29307111-6	2018	Daily nitrate intake (0.5 mmol L-1) restored nitrate levels, decreased ALT and AST levels, and prevented cell senescence and structural and glucose and lipid metabolism degeneration in liver tissue both in D-galactose (D-gal)-induced ageing mice (n=10) and in natural aged mice (n=10).	Nitrates	6-13	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	79-82
29377837-1	2018	In this paper, a system consisting of acid-washed zero-valent iron (ZVI), ferrous ion (Fe2+), and hydrogen peroxide (H2O2) was employed for the removal of nitrate (NO3-) from water, and the reaction mechanism for this is discussed.	Nitrates	155-162	NBL1, DAN family BMP antagonist	Homo sapiens	164-167
30099420-7	2018	RESULTS: Results: When studying the content of methemoglobin among adult population in village areas, where well water with a high concentration of nitrates is consumed and in the city where centralized water supply is used, it was observed that rural people have a higher level of methemoglobin.	Nitrates	148-156	hemoglobin subunit gamma 2	Homo sapiens	47-60
28693108-0	2017	Nitrate release from waste rock dumps in the Elk Valley, British Columbia, Canada.	Nitrates	0-7	potassium voltage-gated channel subfamily H member 8	Homo sapiens	45-48
28763658-8	2017	Isotopes of delta15N-NO3- and delta18O-NO3- verified that nitrate in groundwater of the NV (with delta15N ranging from 1.7% to 4.7%) was sourced from soil and precipitation.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
28763658-8	2017	Isotopes of delta15N-NO3- and delta18O-NO3- verified that nitrate in groundwater of the NV (with delta15N ranging from 1.7% to 4.7%) was sourced from soil and precipitation.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
28793404-4	2017	The simulated wastewater included sulphate (27.2mgL-1), nitrate (7.6mgL-1), ammonium (9.1mgL-1), phosphate (7.4mgL-1), and chloride (47.2mgL-1).	Nitrates	56-63	LLGL scribble cell polarity complex component 1	Homo sapiens	68-73
28793404-4	2017	The simulated wastewater included sulphate (27.2mgL-1), nitrate (7.6mgL-1), ammonium (9.1mgL-1), phosphate (7.4mgL-1), and chloride (47.2mgL-1).	Nitrates	56-63	LLGL scribble cell polarity complex component 1	Homo sapiens	68-73
29187692-11	2017	T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria.	Nitrates	83-90	NIN like protein 7	Arabidopsis thaliana	123-127
29187692-11	2017	T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria.	Nitrates	83-90	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	132-137
29187692-11	2017	T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria.	Nitrates	154-161	NIN like protein 7	Arabidopsis thaliana	123-127
29187692-11	2017	T-DNA insertion plant lines of the genes for two transcription factors involved in nitrate signaling in Arabidopsis roots, NLP7 and TCP20, showed similar nitrate-dependent shifts in root-associated bacterial communities from the wild-type, whereas minor differences were observed in root-associated bacteria.	Nitrates	154-161	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	132-137
28693108-1	2017	The origin, distribution and leaching of nitrate (NO3-) from coal waste rock dumps in the Elk Valley, British Columbia, Canada were defined using chemical and NO3- isotope analyses (delta15N- and delta18O-NO3-) of solids samples of pre- and post-blast waste rock and from thick (up to 180m) unsaturated waste rock dump profiles constructed between 1982 and 2012 as well as water samples collected from a rock drain located at the base of one dump and effluent from humidity cell (HC) and leach pad (LP) tests on waste rock.	Nitrates	41-48	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
29629873-8	2017	ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling.	Nitrates	188-195	diazepam binding inhibitor-like 5	Rattus norvegicus	0-3
29629873-8	2017	ELP-VEGF infusion increased total plasma soluble fms-like tyrosine kinase-1 levels but dramatically reduced free plasma soluble fms-like tyrosine kinase-1 and induced urinary excretion of nitrate/nitrite, indicating enhanced renal nitric oxide signaling.	Nitrates	188-195	vascular endothelial growth factor A	Rattus norvegicus	4-8
28871315-2	2017	Multiday incubations of effluent collected from the Branford and New Haven, Connecticut, waste water treatment plants (WWTP) revealed low but steady conversion of organic nitrogen to nitrate (NO3-).	Nitrates	183-190	NBL1, DAN family BMP antagonist	Homo sapiens	192-195
28661182-5	2017	OBJECTIVES: We implemented Bayesian-distributed lag interaction models to identify sensitive prenatal windows for the influence of nitrate (NO3-) on child asthma, accounting for effect modification by sex and stress.	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
28898831-4	2017	In addition, higher NO3- removal by microalgae assimilation led to better water quality in AA, which made up for the deficiencies of poor aquaponic management of nitrate.	Nitrates	162-169	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
28850721-0	2017	The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1.	Nitrates	57-64	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	16-22
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	28-35	NIN like protein 7	Arabidopsis thaliana	282-286
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	302-309	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	172-178
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	302-309	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	227-233
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	302-309	nitrate transporter 1.1	Arabidopsis thaliana	254-260
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	302-309	NIN like protein 7	Arabidopsis thaliana	282-286
28850721-7	2017	Nitrate uptake was decreased in the mutant along with reduced expression of the nitrate transporter/sensor gene NRT1.1, while nitrate reduction and amino acid content were enhanced in roots along with increased expression of several nitrate assimilatory genes.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	112-118
28850721-7	2017	Nitrate uptake was decreased in the mutant along with reduced expression of the nitrate transporter/sensor gene NRT1.1, while nitrate reduction and amino acid content were enhanced in roots along with increased expression of several nitrate assimilatory genes.	Nitrates	80-87	nitrate transporter 1.1	Arabidopsis thaliana	112-118
28850721-8	2017	These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network.	Nitrates	77-84	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	59-65
28850721-0	2017	The Arabidopsis CPSF30-L gene plays an essential role in nitrate signaling and regulates the nitrate transceptor gene NRT1.1.	Nitrates	57-64	nitrate transporter 1.1	Arabidopsis thaliana	118-124
28850721-8	2017	These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network.	Nitrates	77-84	nitrate transporter 1.1	Arabidopsis thaliana	117-121
28850721-8	2017	These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network.	Nitrates	178-185	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	59-65
28850721-3	2017	We report here the identification of a nitrate regulatory mutant whose mutation mapped to the Cleavage and Polyadenylation Specificity Factor 30 gene (CPSF30-L).	Nitrates	39-46	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	151-157
28850721-8	2017	These findings indicate that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.1 expression, thus adding an important component to the nitrate signaling network.	Nitrates	178-185	nitrate transporter 1.1	Arabidopsis thaliana	117-121
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	28-35	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	172-178
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	28-35	cleavage and polyadenylation specificity factor 30	Arabidopsis thaliana	227-233
28850721-4	2017	In the mutant, induction of nitrate-responsive genes was inhibited independent of the ammonium conditions and was restored by expression of the wild-type 65 kDa encoded by CPSF30-L. Molecular and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in response to nitrate.	Nitrates	28-35	nitrate transporter 1.1	Arabidopsis thaliana	254-260
28570975-12	2017	Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources.	Nitrates	8-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	49-52
28570975-12	2017	Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources.	Nitrates	8-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
28165641-1	2017	Nitrate (NO3-) supplementation resulting in higher plasma nitrite (NO2-) is reported to lower resting mean arterial blood pressure (MAP) and oxygen uptake (VO2 ) during submaximal exercise in non-athletic populations, whereas effects in general are absent in endurance-trained individuals.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
28570975-12	2017	Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources.	Nitrates	8-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
28570975-12	2017	Surface nitrates and phosphates outflux from the Sea of Marmara to the Aegean Sea was higher than the influx from the Black Sea through Bosporus strait, indicating high enrichment of nutrients in the Sea of Marmara from anthropogenic sources.	Nitrates	8-16	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	78-81
29064247-5	2017	Upon amendment with phosphate, the consortium completely degraded up to ~10 mM SCN- to ammonium and sulfate, with some evidence of nitrification of the ammonium to nitrate.	Nitrates	164-171	sorcin	Homo sapiens	79-82
29185502-1	2017	Nitrogen (N) as a nutrient, in the form of nitrate (NO3-), is essential for plant growth.	Nitrates	43-50	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
29035054-0	2017	Quantum Yields of Nitrite (NO2-) from the Photolysis of Nitrate (NO3-) in Ice at 313 nm.	Nitrates	56-63	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
28954516-4	2017	Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier.	Nitrates	0-7	latexin	Homo sapiens	37-40
29143202-0	2017	Tobacco plants expressing the maize nitrate transporter ZmNrt2.1 exhibit altered responses of growth and gene expression to nitrate and calcium.	Nitrates	36-43	nitrate transport 2	Zea mays	56-64
29143202-3	2017	In this report, we introduced into tobacco (Nicotiana tabacum) the constitutively expressed maize high-affinity transporter ZmNrt2.1 gene that would bypass the tight control for the endogenous nitrate-responsive genes.	Nitrates	193-200	nitrate transport 2	Zea mays	124-132
29143202-5	2017	RESULTS: We found that the ZmNrt2.1-expressing plants had better root growth than the wild type plants when Ca2+ was deficient regardless of the nitrate levels.	Nitrates	145-152	nitrate transport 2	Zea mays	27-35
28954516-4	2017	Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier.	Nitrates	0-7	latexin	Homo sapiens	48-51
28954516-4	2017	Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier.	Nitrates	0-7	latexin	Homo sapiens	48-51
28954516-4	2017	Nitrate concentrations varied by 4.4 muM (+-0.2 muM) over a 10 day period at Kiattuut Sermiat and 3.0 muM (+-0.2 muM) over a 14 day period at Leverett Glacier.	Nitrates	0-7	latexin	Homo sapiens	48-51
28387958-5	2017	The method was also found to be suitable for the preconcentration of an anion (nitrate at 100 muM) in presence of a second anion at a very high concentration (50 mM formate).	Nitrates	79-86	latexin	Homo sapiens	94-97
28387958-6	2017	The detection limits for the four anions chloride, nitrate, perchlorate, and formate could be lowered from 4, 4.3, 4.2, and 7.2 muM obtained without trapping respectively to 127, 142, 139, and 451 nM with trapping.	Nitrates	51-58	latexin	Homo sapiens	128-131
28941934-8	2017	Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P &lt; 0.001).	Nitrates	57-64	immunoglobulin kappa variable 1-16	Homo sapiens	131-134
28941934-8	2017	Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P &lt; 0.001).	Nitrates	57-64	immunoglobulin kappa variable 1-16	Homo sapiens	150-153
28941934-8	2017	Plasma nitrite concentrations significantly increased in nitrate supplementation compared to Placebo and Baseline (502 +- 246 nmol L-1; 73 +- 45 nmol L-1; 74 +- 49 nmol L-1 respectively; n = 11; P &lt; 0.001).	Nitrates	57-64	immunoglobulin kappa variable 1-16	Homo sapiens	150-153
28750288-1	2017	Excessive nitrate (NO3-) concentration in groundwater raises health and environmental issues that must be addressed by all European Union (EU) member states under the Nitrates Directive and the Water Framework Directive.	Nitrates	10-17	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
28067100-10	2017	In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice.	Nitrates	80-87	apolipoprotein E	Mus musculus	113-117
28067100-10	2017	In turn, the pre- and post-exercise plasma concentrations of nitrite (NO2-) and nitrate (NO3-) were decreased in ApoE/LDLR-/- as compared to that in age-matched WT mice.	Nitrates	80-87	low density lipoprotein receptor	Mus musculus	118-122
28482109-4	2017	All investigated tree species showed highest uptake rates for NH4+ (ammonium), followed by glycine and NO3- (nitrate).	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
28750288-1	2017	Excessive nitrate (NO3-) concentration in groundwater raises health and environmental issues that must be addressed by all European Union (EU) member states under the Nitrates Directive and the Water Framework Directive.	Nitrates	167-175	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
29049377-9	2017	Thus, our data support the idea that in S-deprived cells THB1 plays a dual role in NO detoxification and in coordinating sulfate limitation with nitrate assimilation.	Nitrates	145-152	uncharacterized protein	Chlamydomonas reinhardtii	57-61
29077028-1	2017	Supplementation with nitrate (NO3-)-rich beetroot juice has been shown to improve exercise performance and cardiovascular (CV) responses, due to an increased nitric oxide (NO) availability.	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
29051766-0	2017	Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation.	Nitrates	77-84	Protein NLP3	Zea mays	39-45
29051766-0	2017	Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation.	Nitrates	77-84	NIN like protein 7	Arabidopsis thaliana	103-107
29051766-0	2017	Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation.	Nitrates	121-128	NIN like protein 7	Arabidopsis thaliana	103-107
29051766-0	2017	Overexpression of the Maize ZmNLP6 and ZmNLP8 Can Complement the Arabidopsis Nitrate Regulatory Mutant nlp7 by Restoring Nitrate Signaling and Assimilation.	Nitrates	121-128	Protein NLP3	Zea mays	39-45
29051766-4	2017	When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism.	Nitrates	61-68	Protein NLP3	Zea mays	16-22
29051766-4	2017	When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism.	Nitrates	61-68	NIN like protein 7	Arabidopsis thaliana	92-96
28876920-2	2017	Uranium(IV) is sparingly soluble, but may be mobilized upon exposure to nitrate (NO3-) and oxygen (O2), which become elevated in groundwater due to seasonal fluctuations in the water table.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
29051766-4	2017	When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism.	Nitrates	100-107	Protein NLP3	Zea mays	16-22
29051766-4	2017	When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism.	Nitrates	100-107	Protein NLP3	Zea mays	16-22
29051766-4	2017	When ZmNLP6 and ZmNLP8 were overexpressed in the Arabidopsis nitrate regulatory gene mutant nlp7-4, nitrate assimilation and induction of nitrate-responsive genes in the transgenic plants were recovered to WT levels, indicating that ZmNLP6 and ZmNLP8 can replace the essential roles of the master nitrate regulatory gene AtNLP7 in nitrate signaling and metabolism.	Nitrates	100-107	Protein NLP3	Zea mays	16-22
29051766-5	2017	ZmNLP6 and ZmNLP8 are localized in the nucleus and can bind candidate nitrate-responsive cis-elements in vitro.	Nitrates	70-77	Protein NLP3	Zea mays	11-17
29051766-7	2017	Thus, ZmNLP6 and ZmNLP8 regulate nitrate signaling in transgenic Arabidopsis plants and may be potential candidates for improving nitrogen use efficiency of maize.	Nitrates	33-40	Protein NLP3	Zea mays	17-23
28689147-1	2017	Quantitative identification of nitrate (NO3--N) sources is critical to the control of nonpoint source nitrogen pollution in an agricultural watershed.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
28625350-4	2017	Inorganic pollutants viz., nitrates (28%; 8%), sulphates (25%; 9%) and phosphates (20%; 7%) removal was higher in ME-BET in comparison with SE-BET and this was also supported with bioelectrogenic activity (584; 160mW/m3).	Nitrates	27-35	delta/notch like EGF repeat containing	Homo sapiens	117-120
28722226-11	2017	SLAC1 and SLAH3 mediate chloride and nitrate transport in guard cells, while SLAH1, SLAH2 and SLAH3 are engaged in root nitrate and chloride acquisition, and anion translocation to the shoot.	Nitrates	37-44	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	0-5
26524711-2	2017	Here, we review pivotal interactions with respect to root acquisition, storage, translocation and metabolism, between the K+ ion and the two major N sources, ammonium (NH4+ ) and nitrate (NO3- ).	Nitrates	179-186	NBL1, DAN family BMP antagonist	Homo sapiens	188-191
28887406-0	2017	Maize NPF6 Proteins Are Homologs of Arabidopsis CHL1 That Are Selective for Both Nitrate and Chloride.	Nitrates	81-88	nitrate transporter 1.1	Arabidopsis thaliana	48-52
28771873-0	2017	Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana.	Nitrates	0-7	bZIP transcription factor family protein	Arabidopsis thaliana	54-58
28771873-0	2017	Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana.	Nitrates	0-7	TGACG motif-binding factor 4	Arabidopsis thaliana	59-63
28578274-0	2017	Synthesis and characterization of a novel organic nitrate NDHP: Role of xanthine oxidoreductase-mediated nitric oxide formation.	Nitrates	50-57	xanthine dehydrogenase	Rattus norvegicus	72-95
28771873-0	2017	Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana.	Nitrates	0-7	Homeodomain-like superfamily protein	Arabidopsis thaliana	68-71
28771873-6	2017	Nitrate reductase-null mutants exhibited nitrate-dependent root hair phenotypes comparable with wild-type plants, indicating that nitrate is the signal that leads to increased formation of root hairs.	Nitrates	41-48	nitrate reductase 1	Arabidopsis thaliana	0-17
28771873-6	2017	Nitrate reductase-null mutants exhibited nitrate-dependent root hair phenotypes comparable with wild-type plants, indicating that nitrate is the signal that leads to increased formation of root hairs.	Nitrates	130-137	nitrate reductase 1	Arabidopsis thaliana	0-17
28771873-8	2017	Phenotypic analyses of these mutants showed that CPC is essential for nitrate-induced responses of root hair development.	Nitrates	70-77	Homeodomain-like superfamily protein	Arabidopsis thaliana	49-52
28771873-10	2017	Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana.	Nitrates	35-42	bZIP transcription factor family protein	Arabidopsis thaliana	57-61
28771873-10	2017	Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana.	Nitrates	35-42	TGACG motif-binding factor 4	Arabidopsis thaliana	62-66
28771873-10	2017	Our results prompted a model where nitrate signaling via TGA1/TGA4 directly regulates the CPC root hair cell fate specification gene to increase formation of root hairs in A. thaliana.	Nitrates	35-42	Homeodomain-like superfamily protein	Arabidopsis thaliana	90-93
28653185-1	2017	MAIN CONCLUSION: The nitrate transporters, belonging to NPF and NRT2 families, play critical roles in nitrate signaling, root growth and nodule development in legumes.	Nitrates	21-28	nrt2	Lotus japonicus	64-68
28921396-3	2017	Nitrate concentration was highly variable from 0.25 to 22 mg L-1 in surface water and from 0.5 to 100 mg L-1 in groundwater.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	61-64
28623824-8	2017	Mechanistically, nitrate treatment reduced renal superoxide generation, pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12 p70) and macrophage infiltration in the kidney.	Nitrates	17-24	interleukin 1 beta	Mus musculus	100-108
28623824-8	2017	Mechanistically, nitrate treatment reduced renal superoxide generation, pro-inflammatory cytokines (IL-1beta, IL-6 and IL-12 p70) and macrophage infiltration in the kidney.	Nitrates	17-24	interleukin 6	Mus musculus	110-114
28623824-10	2017	In another cohort of mice, two weeks of nitrate supplementation lowered superoxide generation and IL-6 expression in bone marrow-derived macrophages.	Nitrates	40-47	interleukin 6	Mus musculus	98-102
28921396-3	2017	Nitrate concentration was highly variable from 0.25 to 22 mg L-1 in surface water and from 0.5 to 100 mg L-1 in groundwater.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	105-108
28817281-5	2017	Metrical fits of Th coordination as a function of nitrate concentration are used to calculate Th-NO3 stability constants, information important to a molecular-scale description of reaction energetics.	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
28716476-1	2017	In the present study, we investigated the influence of phenanthrene (PHE), a three-ring polycyclic aromatic hydrocarbon (PAH) compound, on nitrate (NO3-) reduction processes in mangrove sediments using microcosms.	Nitrates	139-146	NBL1, DAN family BMP antagonist	Homo sapiens	148-151
29026794-1	2017	BACKGROUND: Nitrite (NO2-) and nitrate (NO3-) contaminations of groundwater are considered as one of the major health challenges in recent decades.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
28928722-6	2017	At high Lac/N ratio (2.97 mol/mol) both fermentative and respiratory nitrate reduction to ammonium occurred, coupled to partial oxidation of lactate to acetate, and to acetate oxidation respectively.	Nitrates	69-76	lactase	Homo sapiens	8-11
28928722-8	2017	At a decreased Lac/N ratio (1.15 mol/mol), the molar percentage of nitrate reduced to ammonium decreased to 58%, even though lactate was supplied in adequate amounts for full ammonification and nitrate remained the growth limiting compound.	Nitrates	67-74	lactase	Homo sapiens	15-18
28928722-8	2017	At a decreased Lac/N ratio (1.15 mol/mol), the molar percentage of nitrate reduced to ammonium decreased to 58%, even though lactate was supplied in adequate amounts for full ammonification and nitrate remained the growth limiting compound.	Nitrates	194-201	lactase	Homo sapiens	15-18
28739973-1	2017	Dietary NO3- (nitrate) and NO2- (nitrite) support  NO (nitric oxide) generation and downstream vascular signaling responses.	Nitrates	14-21	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
28798125-3	2017	Nitrate levels increased in the colonic lumen because epithelial expression of Nos2, the gene encoding inducible nitric oxide synthase, was elevated in the absence of PPAR-gamma signaling.	Nitrates	0-7	nitric oxide synthase 2	Homo sapiens	79-83
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Mus musculus	9-12
28710281-1	2017	Nitrate (NO3-) and nitrite (NO2-) are known to be cardioprotective and to alter energy metabolism in vivo NO3- action results from its conversion to NO2- by salivary bacteria, but the mechanism(s) by which NO2- affects metabolism remains obscure.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Mus musculus	106-109
28285190-0	2017	Nitrate decreases xanthine oxidoreductase-mediated nitrite reductase activity and attenuates vascular and blood pressure responses to nitrite.	Nitrates	0-7	xanthine dehydrogenase	Rattus norvegicus	18-41
28671819-4	2017	The reduced, ferrous cytoglobin can bind oxygen and will react with NO in a dioxygenation reaction to form nitrate, which dampens NO signaling.	Nitrates	107-114	cytoglobin	Homo sapiens	21-31
28285190-3	2017	Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate.	Nitrates	79-86	xanthine dehydrogenase	Rattus norvegicus	10-33
28285190-3	2017	Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate.	Nitrates	79-86	xanthine dehydrogenase	Rattus norvegicus	35-38
28285190-4	2017	However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite.	Nitrates	39-46	xanthine dehydrogenase	Rattus norvegicus	58-61
28285190-5	2017	We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation.	Nitrates	21-28	xanthine dehydrogenase	Rattus norvegicus	190-193
28285190-5	2017	We hypothesized that nitrate attenuates the vascular and blood pressure responses to nitrite either by interfering with nitrite influx into vascular tissue, or by competing with nitrite for XOR, thus inhibiting XOR-mediated NO generation.	Nitrates	21-28	xanthine dehydrogenase	Rattus norvegicus	211-214
28285190-12	2017	Next, we used chemiluminescence-based NO detection to examine whether nitrate attenuates XOR-mediated nitrite reductase activity.	Nitrates	70-77	xanthine dehydrogenase	Rattus norvegicus	89-92
28429398-6	2017	The bacterial denitrifer method was used to convert 20 muM of collected NO2- or nitrate (NO3- ) into N2 O and was carried out on an Isoprime continuous flow isotope ratio mass spectrometer.	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
28285190-14	2017	Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite.	Nitrates	32-39	xanthine dehydrogenase	Rattus norvegicus	49-52
28285190-14	2017	Together, our results show that nitrate inhibits XOR-mediated NO production from nitrite, and this mechanism may explain how nitrate attenuates the vascular and blood pressure responses to nitrite.	Nitrates	125-132	xanthine dehydrogenase	Rattus norvegicus	49-52
28262362-4	2017	The reduction of Cr(VI) by NO2- was limited in water, whereas it was significant in ice with the simultaneous oxidation of NO2- to nitrate (NO3-).	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
29964603-2	2017	The results showed that organics was the main component of PM1, and the proportion of nitrate was higher than that of sulfate in autumn and winter.	Nitrates	86-93	transmembrane protein 11	Homo sapiens	59-62
28717175-7	2017	Interestingly, MARC1, which encodes an enzyme discovered to catalyze reduction of nitrate to NO, was identified as a novel VEGFR-2 regulated gene.	Nitrates	82-89	mitochondrial amidoxime-reducing component 1	Oryctolagus cuniculus	15-20
29964603-7	2017	Nitrate was the major contributor of NR-PM1 during the polluted period, while organics was significantly higher than that during clean period.	Nitrates	0-7	transmembrane protein 11	Homo sapiens	40-43
28536248-5	2017	We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification.	Nitrates	283-290	chloride channel A	Arabidopsis thaliana	63-81
28536248-5	2017	We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification.	Nitrates	283-290	chloride channel A	Arabidopsis thaliana	83-88
28536248-5	2017	We provide evidence that this novel conductance is mediated by chloride channel a (CLC-a), a member of the anion/H+ exchanger family formerly implicated in stomatal movements in Arabidopsis H+-dependent currents were absent in clc-a knock-out vacuoles, and canonical CLC-a-dependent nitrate/H+ antiport was inhibited by low concentrations of PI(3,5)P2 Finally, using the pH indicator probe BCECF, we show that CLC-a inhibition contributes to vacuolar acidification.	Nitrates	283-290	chloride channel A	Arabidopsis thaliana	227-232
28656558-8	2017	Organic carbon increased the sensor nitrate plus nitrite results, not only in waters with high organic carbon concentrations, but also at the lower concentrations (&lt; 10 mg C L-1) typical of boreal stream, river, and lake waters.	Nitrates	36-43	adhesion G protein-coupled receptor L1	Homo sapiens	175-180
28419436-4	2017	We found that net nitrate (NO3- ) bioavailability is positively related to MAT (r2  = 0.79, P = 0.0033), and AOA DNA abundance is positively related to both NO3- availability (r2  = 0.34, P = 0.0071) and MAT (r2  = 0.34, P &lt; 0.001).	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
28319596-3	2017	The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for more than 1 week has beneficial effects on SBP and DBP.	Nitrates	107-114	selenium binding protein 1	Homo sapiens	178-181
29657554-6	2017	Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N).	Nitrates	55-62	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
29657554-6	2017	Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N).	Nitrates	92-99	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
29657554-6	2017	Further, the circulation under 3 mL min-1 elevated the nitrate removal by 33% and the final nitrate concentration fell below the maximum contaminant level of 10 mg L-1 nitrate-nitrogen (NO3-N).	Nitrates	92-99	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
28647259-6	2017	The reduction rate of SNA (sulfate, nitrate and ammonium) concentrations was significantly higher than that of PM2.5 in 2017, implying that the current key strategy toward controlling air pollutants from the industrial sector is more powerful for SNA.	Nitrates	36-43	snail family transcriptional repressor 1	Homo sapiens	22-25
28319596-3	2017	The objective was to conduct a meta-analysis of randomized controlled trials that examined whether dietary nitrate supplementation for more than 1 week has beneficial effects on SBP and DBP.	Nitrates	107-114	D-box binding PAR bZIP transcription factor	Homo sapiens	186-189
28319596-11	2017	Overall, dietary nitrate was associated with a significant decline in SBP [-4.1 mmHg (95% confidence interval: -6.1, -2.2); P &lt; 0.001] and DBP [-2.0 mmHg (95% confidence interval: -3.0, -0.9); P &lt; 0.001].	Nitrates	17-24	selenium binding protein 1	Homo sapiens	70-73
28319596-11	2017	Overall, dietary nitrate was associated with a significant decline in SBP [-4.1 mmHg (95% confidence interval: -6.1, -2.2); P &lt; 0.001] and DBP [-2.0 mmHg (95% confidence interval: -3.0, -0.9); P &lt; 0.001].	Nitrates	17-24	D-box binding PAR bZIP transcription factor	Homo sapiens	142-145
27987212-5	2017	Comparison of nitrate-grown wild-type with AOX knockdown and overexpression plants showed a negative correlation between AOX amount and NO amount following AA.	Nitrates	14-21	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	43-46
27987212-5	2017	Comparison of nitrate-grown wild-type with AOX knockdown and overexpression plants showed a negative correlation between AOX amount and NO amount following AA.	Nitrates	14-21	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	121-124
28680423-8	2017	Use of bioreactors to study the effect of nitrate injection on sulfate reduction showed that accumulation of nitrite inhibited SRB activity at 2.5 M but not at 0.5 M NaCl.	Nitrates	42-49	chaperonin containing TCP1 subunit 4	Homo sapiens	127-130
28370621-5	2017	In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport.	Nitrates	10-17	nitrate transporter 1.1	Arabidopsis thaliana	3-7
28370621-5	2017	In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport.	Nitrates	10-17	nitrate transporter 1.1	Arabidopsis thaliana	105-109
28370621-5	2017	In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport.	Nitrates	155-162	nitrate transporter 1.1	Arabidopsis thaliana	3-7
28370621-5	2017	In nrt1.1 nitrate transport mutants, plant Na+ accumulation was partially defective, which suggests that NRT1.1 either partially mediates or modulates the nitrate-dependent Na+ transport.	Nitrates	155-162	nitrate transporter 1.1	Arabidopsis thaliana	105-109
28680423-10	2017	A diverse microbial community dominated by the SRB Desulfovibrio was observed at 0.5 M NaCl both in the presence and absence of nitrate.	Nitrates	128-135	chaperonin containing TCP1 subunit 4	Homo sapiens	47-50
28487127-6	2017	Moreover, docking study of the synthesized compounds on EGFR (PDB code: 1M17) and cytotoxicity study indicated that N-1 phenyl para substitution, pyrazole C-3 alkyl substitution and tethering the nitrate moiety through butyl group had a significant impact on the activity.	Nitrates	196-203	epidermal growth factor receptor	Homo sapiens	56-60
28488152-7	2017	Furthermore, asthma ERVs was significantly associated with concentrations of nitrate (NO3-), with the RR for each 1 mug m-3 increase in NO3- concentrations being 1.004 (95% CI = 1.001-1.007) at lag 0 day.	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
28617311-1	2017	This study aimed to investigate whether the -1026(A&gt;C)(rs2779249) and +2087(A&gt;G)(2297518) polymorphisms in the NOS2 gene were associated with chronic periodontitis (CP) and with salivary levels of nitrite (NO2-) and/or nitrate + nitrite (NOx).	Nitrates	225-232	nitric oxide synthase 2	Homo sapiens	117-121
28488152-7	2017	Furthermore, asthma ERVs was significantly associated with concentrations of nitrate (NO3-), with the RR for each 1 mug m-3 increase in NO3- concentrations being 1.004 (95% CI = 1.001-1.007) at lag 0 day.	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
27997263-1	2017	We aimed to compare the effects of two different dosing durations of dietary nitrate (NO3-) supplementation on 1 and 4 km cycling time-trial performance in highly trained cyclists.	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
28328165-6	2017	Of the two chlorophytes, one grew significantly faster on nitrate (NO3- ), whereas the other grew significantly faster on NH4+ .	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
28489820-7	2017	Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment.	Nitrates	64-71	calcium-dependent protein kinase 1	Arabidopsis thaliana	12-17
28237470-3	2017	Land use of the watershed is mainly agricultural leading to groundwater nitrate concentrations &gt;50mgL-1 and a need for water treatment prior to utilization as drinking water.	Nitrates	72-79	LLGL scribble cell polarity complex component 1	Homo sapiens	101-106
28489820-7	2017	Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment.	Nitrates	64-71	calcium-dependent protein kinase 30	Arabidopsis thaliana	18-23
28489820-7	2017	Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment.	Nitrates	64-71	calcium-dependent protein kinase 32	Arabidopsis thaliana	24-29
28489820-7	2017	Conditional cpk10 cpk30 cpk32 and nlp7 mutants similarly impair nitrate-stimulated system-wide shoot growth and root establishment.	Nitrates	64-71	NIN like protein 7	Arabidopsis thaliana	34-38
28426211-1	2017	A limited number of ground measurements of dry particulate nitrate deposition (NO3-) makes it difficult and challenging to fully know the status of the spatial and temporal variations of dry NO3- depositions over China.	Nitrates	59-66	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
28152440-5	2017	Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring.	Nitrates	133-140	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
28152440-5	2017	Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring.	Nitrates	200-207	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
28152440-5	2017	Whereas ion exchange between Cl- and SO42- counter-ions in the polymer and NO3- from water is the main responsible for the effective nitrate removal in PANI, as assessed by FTIR and XPS analyses, the nitrate removal mechanism on PPy is based in an electron transfer from the polymer to nitrate through N sites located in the pyrrolic ring.	Nitrates	200-207	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
28228237-1	2017	At the catchment scale, a complex mosaic of environmental, hydrogeological and physicochemical characteristics combine to regulate the distribution of groundwater and stream nitrate (NO3-).	Nitrates	174-181	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
28187386-1	2017	A novel DEAMOX system was developed for nitrogen removal from domestic wastewater and nitrate (NO3--N) sewage in sequencing batch reactor (SBR).	Nitrates	86-93	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
28425719-3	2017	Monodentate mononuclear (MM1) surface complexes are shown to lead to the most favorable thermodynamic adsorption for both bicarbonate and nitrate with -63.91 and -28.25 kJ/mol, respectively, under neutral conditions.	Nitrates	138-145	prefoldin subunit 5	Homo sapiens	25-28
28131792-10	2017	Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue.	Nitrates	207-214	interleukin 1 beta	Homo sapiens	12-16
28131792-10	2017	Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue.	Nitrates	207-214	interleukin 1 receptor antagonist	Homo sapiens	86-110
28131792-10	2017	Blockade of IL-1 signaling in the BLA, but not in the caudate putamen or mNAcS, using IL-1 receptor antagonist (IL-1Ra) attenuated heroin-conditioned immunosuppression of NO production as measured by plasma nitrate/nitrite and iNOS mRNA expression in spleen tissue.	Nitrates	207-214	interleukin 1 receptor antagonist	Homo sapiens	112-118
28201747-2	2017	Nitrate (NO3-) has a relevant role in plant-like organisms, first as a nitrogen source for growth and second as a signalling molecule.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
28201747-4	2017	Transporters provide a first step for influx/efflux, homeostasis, and sensing of nitrate; and NIT2 is the key transcription factor (RWP-RK) for mediating the nitrate-dependent activation of a number of genes.	Nitrates	81-88	nitrilase family member 2	Homo sapiens	94-98
28201747-4	2017	Transporters provide a first step for influx/efflux, homeostasis, and sensing of nitrate; and NIT2 is the key transcription factor (RWP-RK) for mediating the nitrate-dependent activation of a number of genes.	Nitrates	158-165	nitrilase family member 2	Homo sapiens	94-98
28073812-8	2017	Here, we show that PSPTO_3957 does not influence growth on rich media, motility or biofilm formation but is necessary for nitrate assimilation and full virulence in P. syringae.	Nitrates	122-129	sulfurtransferase TusA family protein	Pseudomonas syringae pv. tomato str. DC3000	19-29
28369507-4	2017	Recent evidence posits that in one nitrate signaling pathway, nitrate sensed by NRT1.1 activates a phospholipase C activity that is necessary for increased cytosolic calcium levels.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	80-84
28369507-4	2017	Recent evidence posits that in one nitrate signaling pathway, nitrate sensed by NRT1.1 activates a phospholipase C activity that is necessary for increased cytosolic calcium levels.	Nitrates	62-69	nitrate transporter 1.1	Arabidopsis thaliana	80-84
28442008-0	2017	Biotransformation of RDX and HMX by Anaerobic Granular Sludge with Enriched Sulfate and Nitrate.	Nitrates	88-95	radixin	Homo sapiens	21-24
28442008-2	2017	The present study investigated the biotransformation of RDX and HMX by anaerobic granular sludge under sulfate- and nitrate-enriched conditions.	Nitrates	116-123	radixin	Homo sapiens	56-59
28442008-3	2017	The results showed that RDX and HMX could be transformed by anaerobic granular sludge when nitrate was present.	Nitrates	91-98	radixin	Homo sapiens	24-27
28442008-4	2017	However, the biotransformation of RDX and HMX was negatively influenced, especially with high nitrate concentrations.	Nitrates	94-101	radixin	Homo sapiens	34-37
28442008-6	2017	The removal of RDX and HMX under both nitrate- and sulfate-enriched conditions was facilitated by the use of glucose as additional substrate.	Nitrates	38-45	radixin	Homo sapiens	15-18
28340298-1	2017	Photolysis of nitrate (NO3-) produces reactive nitrogen and oxygen species via three different channels, forming: (1) nitrogen dioxide (NO2) and hydroxyl radical ( OH), (2) nitrite (NO2-) and oxygen atom (O(3P)), and (3) peroxynitrite (ONOO-).	Nitrates	14-21	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
27487980-0	2017	Zn-biofortification enhanced nitrogen metabolism and photorespiration process in green leafy vegetable Lactuca sativa L. BACKGROUND: Excessive rates of nitrogen (N) fertilizers may result in elevated concentrations of nitrate (NO3- ) in plants.	Nitrates	218-225	NBL1, DAN family BMP antagonist	Homo sapiens	227-230
27921261-0	2017	Attempting to Compensate for Reduced Neuronal Nitric Oxide Synthase Protein with Nitrate Supplementation Cannot Overcome Metabolic Dysfunction but Rather Has Detrimental Effects in Dystrophin-Deficient mdx Muscle.	Nitrates	81-88	nitric oxide synthase 1, neuronal	Mus musculus	37-67
28391923-5	2017	During HEa and HEc, a shallow boundary layer, stagnant meteorological conditions, and high humidity favored the formation of high-nitrate concentrations, which were mainly produced by three different processes - daytime photochemical production, gas-particle partitioning, and nighttime heterogeneous reactions - and the decline in visibility was mainly induced by NR-PM1.	Nitrates	130-137	NDC80 kinetochore complex component	Homo sapiens	15-18
28339983-4	2017	A T-DNA insertion mutant of ACR11 exhibited a reduced GS activity under low nitrate conditions and reduced glutamine levels.	Nitrates	76-83	uridylyltransferase-like protein	Arabidopsis thaliana	28-33
28032637-0	2017	Nitrogen Limitation Adaptation (NLA) is involved in source-to-sink remobilization of nitrate by mediating the degradation of NRT1.7 in Arabidopsis.	Nitrates	85-92	SPX (SYG1/Pho81/XPR1) domain-containing protein	Arabidopsis thaliana	32-35
28032637-0	2017	Nitrogen Limitation Adaptation (NLA) is involved in source-to-sink remobilization of nitrate by mediating the degradation of NRT1.7 in Arabidopsis.	Nitrates	85-92	nitrate transporter 1.1	Arabidopsis thaliana	125-129
28088722-2	2017	Empirical mass-balance (nitrogen in/nitrogen out) approaches for estimating nitrogen (N) removal in CWs do not characterise the final fate of N; where nitrate (NO3--N) could be reduced to either ammonium (NH4+-N) or N2 with the potential for significant production of N2O.	Nitrates	151-158	NBL1, DAN family BMP antagonist	Homo sapiens	160-163
28153714-2	2017	A significant source of NO is dietary nitrate (NO3), which is initially metabolized by oral bacteria into nitrite (NO2-) and is subsequently converted into NO once digested in the acidic gastric environment.	Nitrates	38-45	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
28262888-3	2017	An SN2-type attack by -OR (-OR = phenoxide, acetate, difluoroacetate, and nitrate) then leads to C(sp3)-OR bond formation.	Nitrates	74-81	solute carrier family 38 member 5	Homo sapiens	3-6
28319056-6	2017	These shoot-derived polypeptides, which we named CEP DOWNSTREAM 1 (CEPD1) and CEPD2, upregulate the expression of the nitrate transporter gene NRT2.1 in roots specifically when nitrate is present in the rhizosphere.	Nitrates	118-125	nitrate transporter 2:1	Arabidopsis thaliana	143-149
28027473-2	2017	In this study, we aimed to reveal the microbial community dynamics in the ISDD process with different influent nitrate (NO3-) concentrations.	Nitrates	111-118	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
27596480-1	2017	The feasibility of NO3- removal by the synergistic action of a prevailing denitrifying anoxic methane oxidising (DAMO), and nitrate-reducing and sulfide-oxidising bacterial (NR-SOB) consortium, using CH4 and H2 S from biogas as electron donors in a biotrickling filter was investigated.	Nitrates	124-131	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
28028076-5	2017	We found that nitrate induces PGC1alpha expression and a switch toward type I and IIa fibers in rat muscle and myotubes in vitro.	Nitrates	14-21	PPARG coactivator 1 alpha	Rattus norvegicus	30-39
28028076-6	2017	Nitrate induces the release of exercise/PGC1alpha-dependent myokine FNDC5/irisin and beta-aminoisobutyric acid from myotubes and muscle in rats and humans.	Nitrates	0-7	PPARG coactivator 1 alpha	Rattus norvegicus	40-49
28028076-6	2017	Nitrate induces the release of exercise/PGC1alpha-dependent myokine FNDC5/irisin and beta-aminoisobutyric acid from myotubes and muscle in rats and humans.	Nitrates	0-7	fibronectin type III domain containing 5	Rattus norvegicus	68-73
28028076-7	2017	Both exercise and nitrate stimulated PGC1alpha-mediated gamma-aminobutyric acid (GABA) secretion from muscle.	Nitrates	18-25	PPARG coactivator 1 alpha	Homo sapiens	37-46
28028076-8	2017	Circulating GABA concentrations were increased in exercising mice and nitrate-treated rats and humans; thus, GABA may function as an exercise/PGC1alpha-mediated myokine-like small molecule.	Nitrates	70-77	PPARG coactivator 1 alpha	Homo sapiens	142-151
27874191-6	2017	Limit of detection values were 6.7 and 4.3 muM for nitrate and nitrite, respectively.	Nitrates	51-58	latexin	Homo sapiens	43-46
28024935-1	2017	Uptake of inorganic nitrate (NO3-) into the salivary circulation is a rate-limiting step for dietary NO3- metabolism in mammals.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
27893932-1	2017	Subsurface brines with high nitrate (NO3- ) concentration are common in desert environments as atmospheric nitrogen is concentrated by the evaporation of precipitation and little nitrogen uptake.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
27894754-5	2017	Furthermore, the applicability of the proposed modified electrode was demonstrated by measuring the concentration of nitrite and nitrate ions in the tap and mineral waters, sausages, salami, and cheese samples.	Nitrates	129-136	nuclear RNA export factor 1	Homo sapiens	149-152
28024935-1	2017	Uptake of inorganic nitrate (NO3-) into the salivary circulation is a rate-limiting step for dietary NO3- metabolism in mammals.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
28024935-6	2017	Salivary and plasma [NO3-] and [NO2-] were higher in the nitrate and nitrate + iodide trials compared to the control trial (P &lt; 0.05).	Nitrates	57-64	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
28024935-6	2017	Salivary and plasma [NO3-] and [NO2-] were higher in the nitrate and nitrate + iodide trials compared to the control trial (P &lt; 0.05).	Nitrates	69-76	NBL1, DAN family BMP antagonist	Homo sapiens	21-24
29744302-8	2017	Presence of 40 mg L-1 nitrates caused reductive transformation of TCE up to 80%.	Nitrates	22-30	immunoglobulin kappa variable 1-16	Homo sapiens	18-21
27682218-2	2017	In case of TBP and DHOA complexes, 3 ligand molecules coordinated in monodentate fashion and 3 nitrate ion in bidentate fashion to Eu3+ to satisfy the 9 coordination of Eu.	Nitrates	95-102	TATA-box binding protein	Homo sapiens	11-14
28224117-7	2017	We demonstrate that PerC controls anaerobic metabolism by increasing expression of genes necessary for nitrate reduction.	Nitrates	103-110	Putative regulator	Escherichia coli	20-24
28224117-8	2017	A tEPEC strain overexpressing PerC exhibited a growth advantage compared to a strain lacking this regulator, when grown anaerobically in the presence of nitrate, conditions mimicking the human intestine.	Nitrates	153-160	PPARG coactivator 1 beta	Homo sapiens	30-34
27890411-5	2017	The focus of this research is to study the impact of the heterogeneous hydrolysis of N2O5 on the formation of nitrate (NO3-) and ammonium (NH4+) in Beijing.	Nitrates	110-117	NBL1, DAN family BMP antagonist	Homo sapiens	119-122
27890411-8	2017	As a result, the hydrolysis of N2O5 led to 21.0% enhancement of nitrate (NO3-) and 7.5% enhancement of ammonium (NH4+).	Nitrates	64-71	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
28032976-1	2017	Nitrate metabolism in Chlamydomonas reinhardtii involves THB1, a monomeric hemoglobin thought to function as a nitric oxide dioxygenase (NOD).	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	57-61
27847182-9	2017	Regional average NO3-N concentrations of groundwater increased coincidently with the increased use of fertilizer, which suggests that nitrate pollution is caused by agricultural activities.	Nitrates	134-141	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
27852448-1	2017	High concentrations of naturally occurring arsenic (As) are typically found in young alluvial and deltaic deposits, and high concentrations of ammonium (NH4+) and nitrate (NO3-) are often present in groundwater affected by anthropogenic activities.	Nitrates	163-170	NBL1, DAN family BMP antagonist	Homo sapiens	172-175
27852448-2	2017	In this study, on the basis of physicochemical characteristics of groundwater and the nitrogen and oxygen isotope composition of NO3-, it was inferred that the main sources of NO3- in the proximal fan of the Choushui River alluvial fan are likely to be ammonium fertilizers, manure, and septic waste; that in the mid-fan and the distal fan, the possible sources are nitrate fertilizers and marine nitrate.	Nitrates	366-373	NBL1, DAN family BMP antagonist	Homo sapiens	176-179
27852448-2	2017	In this study, on the basis of physicochemical characteristics of groundwater and the nitrogen and oxygen isotope composition of NO3-, it was inferred that the main sources of NO3- in the proximal fan of the Choushui River alluvial fan are likely to be ammonium fertilizers, manure, and septic waste; that in the mid-fan and the distal fan, the possible sources are nitrate fertilizers and marine nitrate.	Nitrates	397-404	NBL1, DAN family BMP antagonist	Homo sapiens	176-179
27916563-1	2017	BACKGROUND: There is no epidemiological study on the association between dietary nitrate (NO3) and nitrite (NO2) and intakes and the risk of type 2 diabetes (T2D).	Nitrates	81-88	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
27842004-2	2017	The compound is synthesized by nitrate route and is found to crystallize in monoclinic P21/n space group.	Nitrates	31-38	H3 histone pseudogene 16	Homo sapiens	87-90
28025145-3	2017	Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis.	Nitrates	78-85	BTB and TAZ domain protein 1	Arabidopsis thaliana	150-153
28025145-3	2017	Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis.	Nitrates	78-85	BTB and TAZ domain protein 2	Arabidopsis thaliana	158-161
28025145-3	2017	Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis.	Nitrates	118-125	BTB and TAZ domain protein 1	Arabidopsis thaliana	150-153
28025145-3	2017	Here, we show that NLP transcription factors, which are key regulators of the nitrate response, directly activate the nitrate-inducible expression of BT1 and BT2 encoding putative scaffold proteins with a plant-specific domain structure in Arabidopsis.	Nitrates	118-125	BTB and TAZ domain protein 2	Arabidopsis thaliana	158-161
28025145-6	2017	These results suggest that direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis.	Nitrates	155-162	BTB and TAZ domain protein 1	Arabidopsis thaliana	48-51
28025145-6	2017	These results suggest that direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis.	Nitrates	155-162	BTB and TAZ domain protein 2	Arabidopsis thaliana	56-59
28057862-5	2017	We also show that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates.	Nitrates	21-28	integrin alpha M	Mus musculus	140-145
28057862-5	2017	We also show that in nitrate-fed mice there is reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression, and myeloperoxidase activity compared with wild-type littermates.	Nitrates	21-28	myeloperoxidase	Mus musculus	162-177
27845046-2	2017	Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness.	Nitrates	176-183	DHFS-FPGS homolog B	Arabidopsis thaliana	41-46
28009868-7	2017	The microfluidic sensor provides an ultralow limit of detection of 0.01 mg L-1, a wide dynamic range from 0.01 to 442 mg L-1, and a high sensitivity of 683.3 muA mg-1 L cm-2 for nitrate ions in real soil solution samples.	Nitrates	178-185	immunoglobulin kappa variable 1-16	Homo sapiens	75-78
28009868-7	2017	The microfluidic sensor provides an ultralow limit of detection of 0.01 mg L-1, a wide dynamic range from 0.01 to 442 mg L-1, and a high sensitivity of 683.3 muA mg-1 L cm-2 for nitrate ions in real soil solution samples.	Nitrates	178-185	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
27845046-2	2017	Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in folate metabolism and nitrogen metabolism under nitrate-limited conditions in darkness.	Nitrates	176-183	DHFS-FPGS homolog B	Arabidopsis thaliana	104-109
29151838-1	2017	Anthropogenic nitrogen (N) emissions to the atmosphere have increased significantly the deposition of nitrate (NO3-) and ammonium (NH4+) to the surface waters of the open ocean, with potential impacts on marine productivity and the global carbon cycle.	Nitrates	102-109	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
28067583-3	2017	The slow rise in root tip ABA levels stimulates expression of nitrate metabolic enzymes and simultaneously activates a negative feedback loop involving the protein phosphatase, ABI2, which reduces nitrate influx via the AtNPF6.3 transceptor.	Nitrates	197-204	abl interactor 2	Homo sapiens	177-181
28067583-3	2017	The slow rise in root tip ABA levels stimulates expression of nitrate metabolic enzymes and simultaneously activates a negative feedback loop involving the protein phosphatase, ABI2, which reduces nitrate influx via the AtNPF6.3 transceptor.	Nitrates	197-204	nitrate transporter 1.1	Arabidopsis thaliana	220-228
28212873-4	2017	The aim of our study was to evaluate the temperament and character personality dimensions in patients with VVS as confirmed by nitrate-induced tilt testing.	Nitrates	127-134	VVS	Homo sapiens	107-110
27773243-3	2017	The X-ray structure revealed that the Pb(II) atom is coordinated by one oxygen and three nitrogen atoms from two qcnh ligands and five oxygen atoms from three nitrate ligands in an 8+1 fashion with a PbN3O6 donor set.	Nitrates	159-166	submaxillary gland androgen regulated protein 3B	Homo sapiens	38-44
28683458-1	2017	Nitric oxide (NO) plays an important role in controlling microcirculatory function, but the effects of exogenous administration of nitrate (NO3-) on the microcirculation have not been well studied.	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
27908452-2	2017	In this study, we investigated the reactions of ozone with DON with a special emphasis on the formation of nitrate (NO3-) and ammonium (NH4+).	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
27794435-5	2017	However, after three weeks with in-cage running wheel, mice fed nitrate ran on average 20% faster and 30% further than controls (p&lt;0.01).	Nitrates	64-71	RAN, member RAS oncogene family	Mus musculus	72-75
28009811-1	2016	BACKGROUND AND AIM: The association of habitual intakes of dietary nitrate (NO3-) and nitrite (NO2-) with blood pressure and renal function is not clear.	Nitrates	67-74	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
27744007-2	2016	Cigarette smoking increases circulating thiocyanate (SCN-), which has been suggested to competitively inhibit salivary nitrate (NO3-) uptake, a rate-limiting step in dietary NO3- metabolism.	Nitrates	119-126	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
27744007-2	2016	Cigarette smoking increases circulating thiocyanate (SCN-), which has been suggested to competitively inhibit salivary nitrate (NO3-) uptake, a rate-limiting step in dietary NO3- metabolism.	Nitrates	119-126	NBL1, DAN family BMP antagonist	Homo sapiens	174-177
27699705-5	2016	Parameters included the maximum specific reduction rates, [Formula: see text], growth rates, [Formula: see text], and yields, Y, for reduction of NO3- (nitrate) to nitrite (NO2-), NO2- to N2O, and N2O to N2, with acetate as the electron donor.	Nitrates	152-159	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
27984871-1	2016	A nitrate ion (NO3-) with its trigonal planar geometry and charges distributed among nitrogen and oxygen atoms can couple to the extensive hydrogen bond network of water to give rise to unique dynamical characteristics.	Nitrates	2-9	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
27984871-10	2016	In the first mechanism, nitrate ion predominantly undergoes out-of-plane rotation, while in the second mechanism, in-plane reorientation of NO3- is favourable.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
27646453-1	2016	This study builds upon prior work showing that methane (CH4) could be utilized as the sole electron donor and carbon source in a membrane biofilm reactor (MBfR) for complete perchlorate (ClO4-) and nitrate (NO3-) removal.	Nitrates	198-205	NBL1, DAN family BMP antagonist	Homo sapiens	207-210
27694216-1	2016	We tested the hypothesis that dietary nitrate (NO3-)-rich beetroot juice (BR) supplementation could partially offset deteriorations in O2 transport and utilization and exercise tolerance after blood donation.	Nitrates	38-45	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
27643659-3	2016	As nitrate loading gradually increased to 5 mg/L (stage 2), perchlorate reduction was slightly promoted and both ClO4- and NO3- were completely removed at an acetate loading of 29.7 mg C/L.	Nitrates	3-10	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
27643659-4	2016	When nitrate loading continued increasing to 10-60 mg/L (stage 3), perchlorate reduction converted to be inhibited, along with nondetectable NO3- and approximately exhausted DOC in effluent.	Nitrates	5-12	NBL1, DAN family BMP antagonist	Homo sapiens	141-144
27541496-2	2016	Atnpf3.1 mutants are affected in hypocotyl elongation and seed germination under conditions of low-nitrate availability.	Nitrates	99-106	Major facilitator superfamily protein	Arabidopsis thaliana	0-8
27541496-6	2016	We further analyzed its substrate specificity towards different GA species using a yeast heterologous system which revealed that (1) NPF3.1 transported not only bioactive GAs but also their precursors and metabolites and (2) the GAs" import activity of NPF3.1 was not affected by the presence of exogenous nitrate.	Nitrates	306-313	Major facilitator superfamily protein	Arabidopsis thaliana	133-139
27541496-6	2016	We further analyzed its substrate specificity towards different GA species using a yeast heterologous system which revealed that (1) NPF3.1 transported not only bioactive GAs but also their precursors and metabolites and (2) the GAs" import activity of NPF3.1 was not affected by the presence of exogenous nitrate.	Nitrates	306-313	Major facilitator superfamily protein	Arabidopsis thaliana	253-259
27541496-12	2016	In addition, NPF3.1 gene expression was upregulated by low exogenous nitrate concentrations and the npf3.1 mutants exhibited a not yet described GA-related phenotype under these conditions.	Nitrates	69-76	Major facilitator superfamily protein	Arabidopsis thaliana	13-19
27541496-13	2016	All together, these results indicated that NPF3.1 is indeed involved in GAs transport in planta under low-nitrate conditions.	Nitrates	106-113	Major facilitator superfamily protein	Arabidopsis thaliana	43-49
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	nitrate reductase [NADH]	Solanum lycopersicum	50-67
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	nitrate reductase [NADH]	Solanum lycopersicum	69-71
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	ferredoxin--nitrite reductase, chloroplastic	Solanum lycopersicum	74-91
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	ferredoxin--nitrite reductase, chloroplastic	Solanum lycopersicum	93-96
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	glutamate dehydrogenase	Solanum lycopersicum	201-224
27639963-7	2016	Nitrate and ammonium assimilating enzymes such as nitrate reductase (NR), nitrite reductase (NiR), glutamine synthetase (GS) and glutamate synthase (GOGAT) were adversely affected by NaCl stress while glutamate dehydrogenase (GDH) showed reverse trend.	Nitrates	0-7	glutamate dehydrogenase	Solanum lycopersicum	226-229
27907130-2	2016	The rate of nitrate increase in the river as documented by Ham and Hatzell (1996) was 0.02 mg N L-1 y-1.	Nitrates	12-19	dull endosperm 1	Zea mays	59-62
27732867-2	2016	Nitrate levels up to the WHO guideline maximum of 50 mg NO3-/L were used in tests.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
27419465-5	2016	Similar rapid transcriptional repression occurred in loss-of-function mutants of the nitrate response factor NLP7 and some transcripts were stabilized by nitrate.	Nitrates	85-92	NIN like protein 7	Arabidopsis thaliana	109-113
27419465-5	2016	Similar rapid transcriptional repression occurred in loss-of-function mutants of the nitrate response factor NLP7 and some transcripts were stabilized by nitrate.	Nitrates	154-161	NIN like protein 7	Arabidopsis thaliana	109-113
27593618-1	2016	BACKGROUND: Dietary inorganic nitrate (NO3-) and its reduced forms nitrite (NO2-) and nitric oxide (NO), respectively, are of critical importance for host defense in the oral cavity.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
27613099-8	2016	eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p &lt; 0.01).	Nitrates	142-149	nitric oxide synthase 3	Homo sapiens	0-4
27613099-8	2016	eNOS gene haplotypes GCB, TCB (G-allele of 894G/T, C-allele -786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p &lt; 0.01).	Nitrates	142-149	pyruvate kinase M1/2	Homo sapiens	26-29
27933040-2	2016	A known important factor in this microbial competition is the ratio of available electron donor and elector acceptor, here expressed as Ac/N ratio (acetate/nitrate-nitrogen).	Nitrates	156-163	apoptotic chromatin condensation inducer 1	Homo sapiens	136-140
27933040-3	2016	We studied the impact of the Ac/N ratio on the nitrate reduction pathways in chemostat enrichment cultures, grown on acetate mineral medium.	Nitrates	47-54	apoptotic chromatin condensation inducer 1	Homo sapiens	29-33
27933040-7	2016	Interestingly, in a broad range of Ac/N ratios a dual limitation of acetate and nitrate occurred with co-occurrence of DNRA bacteria and denitrifiers.	Nitrates	80-87	apoptotic chromatin condensation inducer 1	Homo sapiens	35-39
27572691-1	2016	Nitrate (NO3-) pollution is a severe problem in urban aquatic systems especially within megacity undergoing rapid urbanization, and mostly, sewage is supposed as the prevailing NO3- source.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
27418517-6	2016	At night, nitrate was mainly formed through the hydrolysis of NO3 and/or N2O5.	Nitrates	10-17	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
27572525-5	2016	RESULTS: Results indicate that LBP treatment improved sperm density, sperm movement, the rate of normal sperm morphology, and protein expression and superoxide dismutase activity in the testes of the mice and decreased the nitrate nitrogen level in the testes of the mice.	Nitrates	223-230	lipopolysaccharide binding protein	Mus musculus	31-34
27572691-1	2016	Nitrate (NO3-) pollution is a severe problem in urban aquatic systems especially within megacity undergoing rapid urbanization, and mostly, sewage is supposed as the prevailing NO3- source.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	177-180
27898774-0	2016	Effects of Feeding Encapsulated Nitrate to Beef Cattle on Ammonia and Greenhouse Gas Emissions from Their Manure in a Short-Term Manure Storage System.	Nitrates	32-39	gastrin	Bos taurus	81-84
27124387-1	2016	In forests of the humid subtropics of China, chronically elevated nitrogen (N) deposition, predominantly as ammonium (NH4+ ), causes significant nitrate (NO3- ) leaching from well-drained acid forest soils on hill slopes (HS), whereas significant retention of NO3- occurs in near-stream environments (groundwater discharge zones, GDZ).	Nitrates	145-152	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
27124387-2	2016	To aid our understanding of N transformations on the catchment level, we studied spatial and temporal variabilities of concentration and natural abundance (delta15 N and delta18 O) of nitrate (NO3- ) in soil pore water along a hydrological continuum in the N-saturated Tieshanping (TSP) catchment, southwest China.	Nitrates	184-191	NBL1, DAN family BMP antagonist	Homo sapiens	193-196
27898774-1	2016	A study was conducted to investigate effects of feeding encapsulated nitrate (EN) to beef cattle on ammonia (NH) and greenhouse gas emissions from their manure.	Nitrates	69-76	gastrin	Bos taurus	128-131
27355518-7	2016	Enrichment of (15)N and (18)O in nitrate is consistent with lithotrophic denitrification of NO3 in the presence of dissolved Mn and Fe.	Nitrates	33-40	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
27418276-5	2016	In contrast, the 17 O anomaly in nitrate (NO3-) in Lake Vida brine indicates that approximately half or more of the NO3- present is derived from atmospheric deposition.	Nitrates	33-40	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
27588710-4	2016	In avr P. infestans potato leaves enhanced NR gene and protein expression was tuned with the depletion of nitrate contents and the increase in nitrite supply at 3 hpi.	Nitrates	106-113	NADH nitrate reductase	Solanum tuberosum	43-45
27593859-6	2016	RESULTS: SIN-1 treatment increased arginase activity in a time- and dose-dependent manner and reciprocally decreased nitrite/nitrate production that was prevented by peroxynitrite scavenger in HUVECs.	Nitrates	125-132	MAPK associated protein 1	Homo sapiens	9-14
27314899-1	2016	Many karst regions are undergoing rapid population growth and expansion of urban land accompanied by increases in wastewater generation and changing patterns of nitrate (NO3(-)) loading to surface and groundwater.	Nitrates	161-168	NBL1, DAN family BMP antagonist	Homo sapiens	170-173
27618259-6	2016	This may represent a different mechanism from P25, where nitrate is mainly reduced by CO2 - radicals generated by the holes at the valence band.	Nitrates	57-64	complement C2	Homo sapiens	86-89
27702902-1	2016	Natural abundance nitrogen and oxygen isotopes of nitrate (delta15NNO3 and delta18ONO3) provide an important tool for evaluating sources and transformations of natural and contaminant nitrate (NO3-) in the environment.	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
27435853-5	2016	Moreover, HY5 acts as a signal that moves from shoot to root to promote nitrate uptake and root growth.	Nitrates	72-79	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	10-13
27731416-0	2016	NIN-like protein 8 is a master regulator of nitrate-promoted seed germination in Arabidopsis.	Nitrates	44-51	Plant regulator RWP-RK family protein	Arabidopsis thaliana	0-18
27731416-3	2016	Here we show that the Arabidopsis NIN-like protein 8 (NLP8) is essential for nitrate-promoted seed germination.	Nitrates	77-84	Plant regulator RWP-RK family protein	Arabidopsis thaliana	34-52
27731416-3	2016	Here we show that the Arabidopsis NIN-like protein 8 (NLP8) is essential for nitrate-promoted seed germination.	Nitrates	77-84	Plant regulator RWP-RK family protein	Arabidopsis thaliana	54-58
27626106-4	2016	In our tests (eight instruments, n = 29), ammonium nitrate (NH4NO3) causes a median CO2+ interference signal of +3.4% relative to nitrate.	Nitrates	51-58	complement C2	Homo sapiens	84-87
27731416-6	2016	NLP8 reduces abscisic acid levels in a nitrate-dependent manner and directly binds to the promoter of CYP707A2, encoding an abscisic acid catabolic enzyme.	Nitrates	39-46	Plant regulator RWP-RK family protein	Arabidopsis thaliana	0-4
27731416-7	2016	Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2.	Nitrates	75-82	Plant regulator RWP-RK family protein	Arabidopsis thaliana	28-32
27731416-7	2016	Genetic analysis shows that NLP8-mediated promotion of seed germination by nitrate requires CYP707A2.	Nitrates	75-82	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	92-100
29964426-1	2016	Based on test results and mass balance, PHA, TP metabolic regularity was revealed under different nitrate nitrogen concentrations in main anoxic stage [c(NO3)] for nitrogen and phosphorus removal in single sludge system with continuous flow, then the effectiveness of using c(NO3) as control parameter was proved from the perspective of the reaction mechanism.	Nitrates	98-105	NBL1, DAN family BMP antagonist	Homo sapiens	276-279
27849257-14	2016	CONCLUSION: Dietary nitrate in diabetic rats provides cardioprotection against IR injury by regulating eNOS and iNOS expression and inhibiting lipid peroxidation in the heart.	Nitrates	20-27	nitric oxide synthase 2	Rattus norvegicus	112-116
27474450-0	2016	Dietary nitrate improves age-related hypertension and metabolic abnormalities in rats via modulation of angiotensin II receptor signaling and inhibition of superoxide generation.	Nitrates	8-15	angiotensinogen	Rattus norvegicus	104-118
27474450-4	2016	This study was designed to test the hypothesis that dietary nitrate supplementation could reduce blood pressure and improve glucose tolerance in aged rats, via attenuation of NADPH oxidase activity and ANG II receptor signaling.	Nitrates	60-67	angiotensinogen	Rattus norvegicus	202-208
27474450-8	2016	Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.	Nitrates	9-16	angiotensinogen	Rattus norvegicus	82-88
27474450-8	2016	Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.	Nitrates	9-16	angiotensin II receptor, type 1a	Rattus norvegicus	100-104
27519268-0	2016	Low dose dietary nitrate improves endothelial dysfunction and plaque stability in the ApoE-/- mouse fed a high fat diet.	Nitrates	17-24	apolipoprotein E	Mus musculus	86-90
27474450-8	2016	Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.	Nitrates	9-16	angiotensin II receptor, type 2	Rattus norvegicus	106-109
27519268-13	2016	CONCLUSION: Low and moderate dose nitrate significantly improved endothelial function and atherosclerotic plaque composition in ApoE-/- mice fed a HFD.	Nitrates	34-41	apolipoprotein E	Mus musculus	128-132
27474450-8	2016	Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.	Nitrates	9-16	angiotensin II receptor, type 1a	Rattus norvegicus	111-115
27474450-8	2016	Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT1A, AT2, AT1A/AT2 ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.	Nitrates	9-16	angiotensin II receptor, type 2	Rattus norvegicus	116-119
27474450-9	2016	Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression.	Nitrates	35-42	angiotensinogen	Rattus norvegicus	191-197
27609225-0	2016	Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.	Nitrates	61-68	xanthine dehydrogenase	Mus musculus	9-12
27609225-0	2016	Enhanced XOR activity in eNOS-deficient mice: Effects on the nitrate-nitrite-NO pathway and ROS homeostasis.	Nitrates	61-68	nitric oxide synthase 3, endothelial cell	Mus musculus	25-29
27609225-8	2016	Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat.	Nitrates	27-34	nitric oxide synthase 3, endothelial cell	Mus musculus	69-73
27609225-8	2016	Following an acute dose of nitrate, plasma nitrite increased more in eNOS-/- compared with wt, and this augmented response was abolished by the selective XOR inhibitor febuxostat.	Nitrates	27-34	xanthine dehydrogenase	Mus musculus	154-157
27609225-10	2016	Dietary supplementation with nitrate increased XOR expression and activity, but concomitantly reduced superoxide generation.	Nitrates	29-36	xanthine dehydrogenase	Mus musculus	47-50
27609225-13	2016	A high dose of dietary nitrate reduced blood pressure in naive eNOS-/- mice, and again this effect was abolished by febuxostat.	Nitrates	23-30	nitric oxide synthase 3, endothelial cell	Mus musculus	63-67
27609225-14	2016	In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS.	Nitrates	90-97	nitric oxide synthase 3, endothelial cell	Mus musculus	15-19
27609225-14	2016	In conclusion, eNOS deficiency is associated with an upregulation of XOR facilitating the nitrate-nitrite-NO pathway and decreasing the generation of ROS.	Nitrates	90-97	xanthine dehydrogenase	Mus musculus	69-72
27745660-4	2016	Higher concentrations of sulfate (SO42-) and organic carbon (OC) in PM2.5 occurred in fall and summer, while higher concentrations of nitrate (NO3-) were observed in winter and spring.	Nitrates	134-141	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
27594514-0	2016	Nitrate salts suppress sporulation and production of enterotoxin in Clostridium perfringens strain NCTC8239.	Nitrates	0-13	cpe	Clostridium perfringens	53-64
27406851-6	2016	In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0).	Nitrates	42-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-98
27406851-6	2016	In addition to growth by fermentation and nitrate reduction, this strain was able to reduce Fe(III), Mn(IV), Co(III) and Cr(VI) when H2 or organic carbon was available as the electron donor, but did not actively reduce oxidized sulfur compounds (e.g. sulfate, thiosulfate or S0).	Nitrates	42-49	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	109-116
27509322-0	2016	Kinetic and Theoretical Study of the Nitrate (NO3) Radical Gas Phase Reactions with N-Nitrosodimethylamine and N-Nitrosodiethylamine.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
27590123-7	2016	We suggest that nitrate and Zn2+ activate a late slower component of the DeltaF/F signals of frog but not of mouse fibres, possibly promoting Ca2+ induced Ca2+ release at level of the RyR3, that in frog muscle fibres are localized in the para-junctional region of the triads and are absent in mouse FDB muscle fibres.	Nitrates	16-23	ryanodine receptor 3	Mus musculus	184-188
27543115-0	2016	Nitrate Controls Root Development through Posttranscriptional Regulation of the NRT1.1/NPF6.3 Transporter/Sensor.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	80-84
27543115-2	2016	In Arabidopsis (Arabidopsis thaliana), the adaptive root response to nitrate (NO3-) depends on the NRT1.1/NPF6.3 transporter/sensor.	Nitrates	69-76	nitrate transporter 1.1	Arabidopsis thaliana	99-112
27585373-4	2016	Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	11-14
27585373-4	2016	Both [MnO2(NO3)](-) and [MnO3(NO3)](-) yield [MnO4](-) via the transfer of oxygen atoms from the remaining nitrate ligand.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
27585373-7	2016	Theoretical studies show crossing from the high-spin to low-spin surface upon neutral oxygen atom transfer from the nitrate ligand in [MnO2(NO3)](-) allows formation of (1)[MnO4](-).	Nitrates	116-123	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
27280428-11	2016	ACh-induced vascular nitrate/nitrite production was in Preg+sFlt-1 and RUPP &lt; Preg, and in RUPP+PlGF &gt; RUPP.	Nitrates	21-28	placental growth factor	Rattus norvegicus	99-103
27593275-3	2016	The aim of this study was therefore to assess how maximum potential denitrification and N2O production rates, and the relationship between the two (relative N2O production), is controlled by availability of nitrate (NO3(-)), carbon (C), phosphorus (P), and temperature.	Nitrates	207-214	NBL1, DAN family BMP antagonist	Homo sapiens	216-219
26641379-2	2016	NO availability increases after consuming nitrate (NO3-).	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Nitrates	46-53	cysteine synthase	Cucumis sativus	165-181
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Nitrates	46-53	cysteine synthase	Cucumis sativus	183-185
27481896-8	2016	A lower citrate concentration was observed in nitrate-grown cucumbers, which was associated with lower MATE (multidrug and toxin compound extrusion) family gene and citrate synthase (CS) gene expression, as well as lower CS activity.	Nitrates	46-53	cysteine synthase	Cucumis sativus	221-223
26896377-4	2016	In the present research, beta-lactoglobulin-pectin nanoparticles were designed to transfer a newly synthesized, anticancer platinum complex (bipyridine ethyl dithiocarbamate Pt(II) nitrate), to the colon.	Nitrates	181-188	beta-lactoglobulin	Bos taurus	25-43
27397895-9	2016	SLAH3 anion channels are not active per se but require extracellular nitrate and phosphorylation by calcium-dependent kinases (CPKs) [11-13].	Nitrates	69-76	SLAC1 homologue 3	Arabidopsis thaliana	0-5
27397895-10	2016	When co-expressed in Xenopus oocytes, however, the electrically silent SLAH1 subunit gates SLAH3 open even in the absence of nitrate- and calcium-dependent kinases.	Nitrates	125-132	SLAC1 homologue 1	Arabidopsis thaliana	71-76
27194250-5	2016	Nitrate was correlated with Na(+) + K(+), Mg(2+), Cl(-) and SO4 (2-) in the shallow aquifer, and the spatial distributions of NO3 (-) exhibited a same pattern with TDS in the shallow aquifer, the NO3 (-) pollution in the middle-deep and deep aquifers is less serious.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
27194250-5	2016	Nitrate was correlated with Na(+) + K(+), Mg(2+), Cl(-) and SO4 (2-) in the shallow aquifer, and the spatial distributions of NO3 (-) exhibited a same pattern with TDS in the shallow aquifer, the NO3 (-) pollution in the middle-deep and deep aquifers is less serious.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	196-199
27208469-2	2016	This key step in thyroid hormone synthesis is inhibited by perchlorate, thiocyanate (SCN) and nitrate (NO3) anions.	Nitrates	94-101	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
27236758-7	2016	Methane production [L/kg of dry matter intake (DMI)] linearly decreased with increasing nitrate concentrations compared with the control, corresponding to a reduction of 6, 13, and 23% for the low, medium, and high diets, respectively.	Nitrates	88-95	DMI	Bos taurus	47-50
27456694-6	2016	In 26 % of the water samples, nitrate concentration is above the human-affected value, 5 mg/l NO3 (-).	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
27456694-12	2016	Loading of factors with K(+) and SO4 (2-), K(+) and NO3 (-), and NO3 (-) and correlation of SO4 (2-) with Cl(-), along with the observed high nitrate concentration, indicate the effect of surface contamination sources on the water quality.	Nitrates	142-149	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
27456694-12	2016	Loading of factors with K(+) and SO4 (2-), K(+) and NO3 (-), and NO3 (-) and correlation of SO4 (2-) with Cl(-), along with the observed high nitrate concentration, indicate the effect of surface contamination sources on the water quality.	Nitrates	142-149	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
26630309-2	2016	Acute nitrate supplementation, at sea level, may reduce oxygen cost during submaximal exercise in hypobaric hypoxia.	Nitrates	6-13	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	34-37
27236758-9	2016	Addition of nitrate increased hydrogen emissions (L/kg of DMI) quadratically by a factor of 2.5, 3.4, and 3.0 (as L/kg of DMI) for the low, medium, and high diets, respectively, compared with the control.	Nitrates	12-19	DMI	Bos taurus	58-61
27236758-9	2016	Addition of nitrate increased hydrogen emissions (L/kg of DMI) quadratically by a factor of 2.5, 3.4, and 3.0 (as L/kg of DMI) for the low, medium, and high diets, respectively, compared with the control.	Nitrates	12-19	DMI	Bos taurus	122-125
27236758-10	2016	Blood methemoglobin levels and nitrate concentrations in milk and urine increased with increasing nitrate intake, but did not constitute a threat for animal health and human food safety.	Nitrates	98-105	hemoglobin subunit gamma 2	Homo sapiens	6-19
27102809-1	2016	Natural abundance nitrate (NO3 (-)) isotopes represent a powerful tool for assessing denitrification, yet the scale and context dependence of relationships between isotopes and denitrification have received little attention, especially in surface soils.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
27340232-4	2016	Artificial microRNA knockdown mutants of AtSLAH1 had significantly reduced shoot Cl(-) accumulation when grown under low Cl(-), whereas shoot Cl(-) increased and the shoot nitrate/chloride ratio decreased following AtSLAH1 constitutive or stelar-specific overexpression when grown in high Cl(-) In both sets of overexpression lines a significant reduction in shoot biomass over the null segregants was observed under high Cl(-) supply, but not low Cl(-) supply.	Nitrates	172-179	SLAC1 homologue 1	Arabidopsis thaliana	41-48
27340232-5	2016	Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport.	Nitrates	73-80	SLAC1 homologue 3	Arabidopsis thaliana	30-37
27340232-5	2016	Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport.	Nitrates	131-138	SLAC1 homologue 3	Arabidopsis thaliana	30-37
27340232-5	2016	Further in planta data showed AtSLAH3 overexpression increased the shoot nitrate/chloride ratio, consistent with AtSLAH3 favouring nitrate transport.	Nitrates	131-138	SLAC1 homologue 3	Arabidopsis thaliana	113-120
27435462-4	2016	Generation of nitrate in the intestinal lumen required inducible nitric oxide synthase (iNOS), which was synthesized constitutively in the mucosa of the terminal ileum but not in the jejunum, duodenum, or cecum.	Nitrates	14-21	nitric oxide synthase 2, inducible	Mus musculus	88-92
27435462-10	2016	This pathway required the methyl-accepting chemotaxis protein (MCP) Tsr and energy taxis toward host-derived nitrate, which we found to be generated by inducible nitric oxide synthase (iNOS) in the ileal mucosa prior to infection.	Nitrates	109-116	nitric oxide synthase 2, inducible	Mus musculus	185-189
26864608-5	2016	Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants.	Nitrates	78-85	nitrate transporter 1.1	Arabidopsis thaliana	8-14
27131407-3	2016	The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
27131407-3	2016	The aim of this study was to assess whether oral intake of a nitrate (NO3-)-rich dietary supplement (amaranth extract) is able to increase NO3- and nitrite (NO2-) levels in blood plasma and saliva of healthy adults.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
26864608-5	2016	Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants.	Nitrates	78-85	nitrate transporter 1.1	Arabidopsis thaliana	27-31
26864608-5	2016	Lack of NRT1.1 in knockout nrt1.1 mutants led to impaired proton tolerance in nitrate-sufficient growth medium, whereas no difference was seen between wild-type plants and NRT1.2-, NRT2.1-, NRT2.2-, and NRT2.4-null mutants.	Nitrates	78-85	nitrate transporter 1.1	Arabidopsis thaliana	8-12
26864608-6	2016	Another nrt1.1 point mutant, which is defective in nitrate uptake but has a normal nitrate-sensing function, also had impaired proton tolerance compared with the wild-type plant.	Nitrates	51-58	nitrate transporter 1.1	Arabidopsis thaliana	8-12
26864608-6	2016	Another nrt1.1 point mutant, which is defective in nitrate uptake but has a normal nitrate-sensing function, also had impaired proton tolerance compared with the wild-type plant.	Nitrates	83-90	nitrate transporter 1.1	Arabidopsis thaliana	8-12
26864608-7	2016	Furthermore, proton stress induced NRT1.1-mediated nitrate uptake.	Nitrates	51-58	nitrate transporter 1.1	Arabidopsis thaliana	35-39
26864608-8	2016	These results indicate that NRT1.1-conferred proton tolerance depends on nitrate uptake activity.	Nitrates	73-80	nitrate transporter 1.1	Arabidopsis thaliana	28-32
26864608-10	2016	We conclude that NRT1.1-mediated nitrate uptake plays a crucial role in plant proton tolerance by alkalifying the rhizosphere.	Nitrates	33-40	nitrate transporter 1.1	Arabidopsis thaliana	17-21
27323160-9	2016	Overexpression of ALDH2 increased cell survival against GTN-induced cytotoxicity and conferred protection from oxidative damage resulting from nitrate tolerance, accompanied by decreased production of intracellular reactive oxygen species and reduced expression of heme oxygenase 1.	Nitrates	143-150	aldehyde dehydrogenase 2 family member	Homo sapiens	18-23
27208280-6	2016	Employing these putative bacterial AvrRpt2 homologs and inactive AvrRpt2 variants, we can uncouple the inhibition of MPK4/MPK11 activation from the cleavage of RIN4 and related members from the so-called nitrate-induced family as well as from auxin signaling.	Nitrates	204-211	MAP kinase 4	Arabidopsis thaliana	117-121
27208280-6	2016	Employing these putative bacterial AvrRpt2 homologs and inactive AvrRpt2 variants, we can uncouple the inhibition of MPK4/MPK11 activation from the cleavage of RIN4 and related members from the so-called nitrate-induced family as well as from auxin signaling.	Nitrates	204-211	RPM1 interacting protein 4	Arabidopsis thaliana	160-164
27197029-7	2016	Within-batch and inter-batch replication yields 1 standard deviation (SD) of &lt;=0.06% for delta(15) N values and &lt;=0.14% for delta(18) O values down to 5 muM nitrate and &lt;=0.08% and &lt;=0.23% at 2 and 1 muM.	Nitrates	163-170	latexin	Homo sapiens	159-162
26846474-3	2016	Nonetheless, gating of the R117H-CFTR can be improved by a variety of pharmacological reagents supposedly acting on NBDs such as ATP analogues, or TMDs (e.g. VX-770 or nitrate).	Nitrates	168-175	CF transmembrane conductance regulator	Homo sapiens	33-37
26846474-12	2016	Moreover, our data demonstrate that a synergistic improvement of R117H-CFTR function can be accomplished with a combined regiment of VX-770 (Ivacaftor), nitrate ion (NO3 (-) ) and N(6) -(2-phenylethyl)-2"-deoxy-ATP (d-PATP), which almost completely rectifies the gating defect of R117H-CFTR.	Nitrates	153-160	CF transmembrane conductance regulator	Homo sapiens	71-75
27171587-0	2016	Decay Mechanism of NO3( ) Radical in Highly Concentrated Nitrate and Nitric Acidic Solutions in the Absence and Presence of Hydrazine.	Nitrates	57-64	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
27208309-7	2016	We found NUE decreased in plants overexpressing BT2 gene compared to wild-type plants under limiting nitrate conditions.	Nitrates	101-108	BTB and TAZ domain protein 2	Arabidopsis thaliana	48-51
27208309-8	2016	In addition, NUE increased compared to wild-type plants under low nitrate conditions in double mutant plants in bt2 and its closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE.	Nitrates	66-73	BTB and TAZ domain protein 2	Arabidopsis thaliana	112-115
27208309-8	2016	In addition, NUE increased compared to wild-type plants under low nitrate conditions in double mutant plants in bt2 and its closely related homolog bt1, indicating a functional redundancy of BT1 and BT2 for NUE.	Nitrates	66-73	BTB and TAZ domain protein 1	Arabidopsis thaliana	148-151
27208309-9	2016	Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions.	Nitrates	18-25	BTB and TAZ domain protein 1	Arabidopsis thaliana	79-82
27208309-9	2016	Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions.	Nitrates	18-25	BTB and TAZ domain protein 2	Arabidopsis thaliana	83-86
27208309-9	2016	Expression of the nitrate transporter genes NRT2.1 and NRT2.4 increased in the bt1/bt2 double mutant compared to wild-type plants, with a concomitant 65% increase in nitrate uptake under low nitrate conditions.	Nitrates	166-173	BTB and TAZ domain protein 1	Arabidopsis thaliana	79-82
28328022-1	2016	RATIONALE: The azide method for measuring the stable isotope ratios of nitrate (NO3- ) is easy to set up.	Nitrates	71-78	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
27243218-10	2016	Furthermore, the concentrations of nitric oxide, nitrite, nitrate, and the ferric reducing ability of plasma decreased with AAC indicating a lower oxidative stress status.	Nitrates	58-65	glycine N-acyltransferase	Bos taurus	124-127
27211528-6	2016	Expression levels of RD22, RD29A, DREB2A, and P5CS1 decreased after nitrate treatment in SoHb-overexpressing plants, while increased in the WT plants.	Nitrates	68-75	BURP domain-containing protein	Arabidopsis thaliana	21-25
27211528-6	2016	Expression levels of RD22, RD29A, DREB2A, and P5CS1 decreased after nitrate treatment in SoHb-overexpressing plants, while increased in the WT plants.	Nitrates	68-75	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	46-51
27506022-3	2016	The results showed that the study region in the southeast was the main nitrate-polluted area, with concentrations of up to 30-120 mg   L-1, in both wet and drought periods, while the nitrate-contaminated area in drought period was about 1.	Nitrates	71-78	immunoglobulin kappa variable 1-16	Homo sapiens	135-138
27506022-6	2016	The nitrate concentration was less than 20 mg   L-1 in north.	Nitrates	4-11	immunoglobulin kappa variable 1-16	Homo sapiens	48-51
26969694-1	2016	UNLABELLED: Members of the Fungi convert nitrate (NO3 (-)) and nitrite (NO2 (-)) to gaseous nitrous oxide (N2O) (denitrification), but the fungal contributions to N loss from soil remain uncertain.	Nitrates	41-48	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
26879980-3	2016	Biological nitrification of ammonia to nitrite (NO2 (-)) and nitrate (NO3 (-)) was mediated by nitrifying bacterial and archaeal biofilm populations.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
27000467-2	2016	We have recently shown that rodent skeletal muscle contains unusually high concentrations of nitrate, compared to blood and other tissues, likely produced by oxidation of NOS1-produced NO.	Nitrates	93-100	nitric oxide synthase 1	Rattus norvegicus	171-175
27000467-6	2016	Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself.	Nitrates	170-177	xanthine dehydrogenase	Rattus norvegicus	61-84
27000467-1	2016	The presence of nitric oxide (NO) synthase enzymes, mainly the NOS1 isoform, in skeletal muscle had been well established; however in the last decade it has been realized that NO may also be produced by reduction of nitrate and tissue nitrite.	Nitrates	216-223	nitric oxide synthase 1	Rattus norvegicus	63-67
27000467-6	2016	Using skeletal muscle tissue homogenates we established that xanthine oxidoreductase (XOR) is at least partially responsible for the generation of nitrite and/or NO from nitrate and that this effect is increased by slight lowering of pH and by other processes related to the exercise itself.	Nitrates	170-177	xanthine dehydrogenase	Rattus norvegicus	86-89
26926793-0	2016	NAR2.1/NRT2.1 functional interaction with NO3(-) and H(+) fluxes in high-affinity nitrate transport in maize root regions.	Nitrates	82-89	high affinity nitrate transporter	Zea mays	0-6
26926793-0	2016	NAR2.1/NRT2.1 functional interaction with NO3(-) and H(+) fluxes in high-affinity nitrate transport in maize root regions.	Nitrates	82-89	nitrate transport 2	Zea mays	7-11
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	47-54	high affinity nitrate transporter	Zea mays	112-118
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	47-54	nitrate transport 2	Zea mays	123-129
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	47-54	nitrate transport 2	Zea mays	201-207
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	47-54	high affinity nitrate transporter	Zea mays	208-214
26938500-3	2016	When 5000 muM nitrate was further added to the influent, total Se removal was again better under thermophilic (70.1 +- 6.6%) when compared to mesophilic (43.6 +- 8.8%) conditions.	Nitrates	14-21	latexin	Homo sapiens	10-13
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	241-248	high affinity nitrate transporter	Zea mays	112-118
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	241-248	nitrate transport 2	Zea mays	123-129
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	241-248	nitrate transport 2	Zea mays	201-207
26926793-6	2016	A significant correlation (P = 0.0023) between nitrate influx and gene transcript levels was observed only when NAR2.1 and NRT2.1 co-expression were considered together, showing for the first time the NRT2.1/NAR2.1 functional interaction in nitrate uptake along the root axis.	Nitrates	241-248	high affinity nitrate transporter	Zea mays	208-214
27010702-5	2016	When nitrate (NO3) radicals are suppressed, high isoprene persists through the night, providing photochemical fuel upon daybreak and leading to a dramatic late-morning ozone peak.	Nitrates	5-12	NBL1, DAN family BMP antagonist	Homo sapiens	14-17
26786906-3	2016	The simultaneous separation and sensitive detection of sodium (Na(+)), potassium (K(+)), ammonium (NH4 (+)), chloride (Cl(-)) and nitrate (NO3 (-)) in a single run was achieved by using 98% 1.5 mM MgSO4 and 2% acetonitrile eluent with a mixed-bed ion-exchange separation column without suppressor column system.	Nitrates	130-137	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
26828278-1	2016	Zinc-aluminum layered double hydroxides with nitrate intercalated (Zn(n)Al-NO3, n=Zn/Al) is an intermediate material for the intercalation of different functional molecules used in a wide range of industrial applications.	Nitrates	45-52	NBL1, DAN family BMP antagonist	Homo sapiens	75-78
26841230-8	2016	The nitrate and sulfite induced indirect TOX photolysis rates were less than 50% of the direct photolysis rates under the conditions of this study.	Nitrates	4-11	thymocyte selection associated high mobility group box	Homo sapiens	41-44
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Nitrates	116-123	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
26828284-2	2016	Complex 1, [Cu(PyBIm)(NO3)(H2O)](NO3), is a four coordinate, distorted square planar species with one ligand (N,N), nitrate and water bound to Cu(II).	Nitrates	116-123	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26682792-4	2016	RESULTS: In myocardium of HFpEF patients and ZSF1-HFpEF rats, we observed the following: 1) E-selectin and intercellular adhesion molecule-1 expression levels were upregulated; 2) NADPH oxidase 2 expression was raised in macrophages and endothelial cells but not in cardiomyocytes; and 3) uncoupling of endothelial nitric oxide synthase, which was associated with reduced myocardial nitrite/nitrate concentration, cGMP content, and PKG activity.	Nitrates	391-398	cytochrome b-245 beta chain	Rattus norvegicus	180-195
27064357-1	2016	Nutrient stoichiometry within a wetland is affected by the surrounding land use, and may play a significant role in the removal of nitrate (NO3-N).	Nitrates	131-138	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
27004464-1	2016	The family of NITRATE TRANSPORTER 2 (NRT2) proteins belongs to the high affinity transport system (HATS) proteins which acts at low nitrate concentrations.	Nitrates	132-139	nitrate transporter 2:1	Arabidopsis thaliana	14-35
27004464-1	2016	The family of NITRATE TRANSPORTER 2 (NRT2) proteins belongs to the high affinity transport system (HATS) proteins which acts at low nitrate concentrations.	Nitrates	132-139	nitrate transporter 2:1	Arabidopsis thaliana	37-41
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrates	229-236	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
26799712-7	2016	The model simulation results also show that the sulphur term (eta(S)) in the kinetic equations of nitrate, nitrite, sulphur and sulphate remains constant, rather than being controlled by its own concentration.	Nitrates	98-105	endothelin receptor type A	Homo sapiens	62-65
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrates	229-236	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrates	229-236	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrates	229-236	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-4	2016	The oxygen radical ligand in AlO(NO3)3(-) is highly reactive and drives the formation of AlO(NO3)2(-) upon loss of NO3( ), AlO2(NO3)2(-) upon NO2( ) loss, or Al(NO2)(NO3)2(-) upon abstraction of an oxygen atom from a neighboring nitrate ligand followed by loss of O2.	Nitrates	229-236	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	100-103
26919711-6	2016	The mechanism for O2 elimination requires oxygen atom abstraction from a nitrate ligand in both AlO(NO3)3(-) and AlO2(NO3)2(-), revealing the hidden complexity in the fragmentation of these clusters.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
26958096-0	2016	Effect of calcitonin gene-related peptide antagonist on the cardiovascular events, mortality, and prostaglandin E2 production by nitrate-induced tolerant rats with acute myocardial infarction.	Nitrates	129-136	calcitonin-related polypeptide alpha	Rattus norvegicus	10-41
26732494-0	2016	Arabidopsis NRT1.5 Mediates the Suppression of Nitrate Starvation-Induced Leaf Senescence by Modulating Foliar Potassium Level.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	12-16
26958096-16	2016	CONCLUSIONS: CGRP could be involved in the mechanism of nitrate tolerance via the inhibition of release of the potent vasodilator CGRP leading to exacerbation of acute myocardial ischemia.	Nitrates	56-63	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
26958096-16	2016	CONCLUSIONS: CGRP could be involved in the mechanism of nitrate tolerance via the inhibition of release of the potent vasodilator CGRP leading to exacerbation of acute myocardial ischemia.	Nitrates	56-63	calcitonin-related polypeptide alpha	Rattus norvegicus	130-134
26877080-3	2016	Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake.	Nitrates	219-226	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	40-50
26877080-3	2016	Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake.	Nitrates	219-226	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	52-55
26877080-3	2016	Here we show that Arabidopsis ELONGATED HYPOCOTYL5 (HY5), a bZIP transcription factor that regulates growth in response to light [2, 3], is a shoot-to-root mobile signal that mediates light promotion of root growth and nitrate uptake.	Nitrates	219-226	basic leucine-zipper 8	Arabidopsis thaliana	60-64
26877080-4	2016	Shoot-derived HY5 auto-activates root HY5 and also promotes root nitrate uptake by activating NRT2.1, a gene encoding a high-affinity nitrate transporter [4].	Nitrates	65-72	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	14-17
26877080-4	2016	Shoot-derived HY5 auto-activates root HY5 and also promotes root nitrate uptake by activating NRT2.1, a gene encoding a high-affinity nitrate transporter [4].	Nitrates	65-72	nitrate transporter 2:1	Arabidopsis thaliana	94-100
26877080-5	2016	In the shoot, HY5 promotes carbon assimilation and translocation, whereas in the root, HY5 activation of NRT2.1 expression and nitrate uptake is potentiated by increased carbon photoassimilate (sucrose) levels.	Nitrates	127-134	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	87-90
26732494-3	2016	Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5.	Nitrates	44-51	nitrate transporter 1.1	Arabidopsis thaliana	116-120
26732494-3	2016	Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5.	Nitrates	44-51	nitrate transporter 1.1	Arabidopsis thaliana	253-257
26732494-3	2016	Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5.	Nitrates	193-200	nitrate transporter 1.1	Arabidopsis thaliana	116-120
26732494-3	2016	Here, we report an interesting finding that nitrate-instead of nitrogen-starvation induced early leaf senescence in nrt1.5 mutant, and present genetic and physiological data demonstrating that nitrate starvation-induced leaf senescence is suppressed by NRT1.5.	Nitrates	193-200	nitrate transporter 1.1	Arabidopsis thaliana	253-257
26732494-5	2016	Further analyses using nrt1.5 single and nia1 nia2 nrt1.5-4 triple mutant showed a negative correlation between nitrate concentration and senescence rate in leaves.	Nitrates	112-119	nitrate transporter 1.1	Arabidopsis thaliana	23-27
26732494-5	2016	Further analyses using nrt1.5 single and nia1 nia2 nrt1.5-4 triple mutant showed a negative correlation between nitrate concentration and senescence rate in leaves.	Nitrates	112-119	nitrate transporter 1.1	Arabidopsis thaliana	51-55
26732494-6	2016	Moreover, when exposed to nitrate starvation, foliar potassium level decreased in nrt1.5, but adding potassium could essentially restore the early leaf senescence phenotype of nrt1.5 plants.	Nitrates	26-33	nitrate transporter 1.1	Arabidopsis thaliana	82-86
26732494-7	2016	Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5.	Nitrates	0-7	high affinity K+ transporter 5	Arabidopsis thaliana	56-60
26732494-7	2016	Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5.	Nitrates	0-7	annexin 1	Arabidopsis thaliana	75-79
26732494-7	2016	Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	83-87
26732494-7	2016	Nitrate starvation also downregulated the expression of HAK5, RAP2.11, and ANN1 in nrt1.5 roots, and appeared to alter potassium level in xylem sap from nrt1.5.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	153-157
26732494-8	2016	These data suggest that NRT1.5 likely perceives nitrate starvation-derived signals to prevent leaf senescence by facilitating foliar potassium accumulation.	Nitrates	48-55	nitrate transporter 1.1	Arabidopsis thaliana	24-28
26729042-5	2016	Using the nitrate/nitrite assay, we also demonstrated that the thrombin- and TFLLR-induced production of nitric oxide was inhibited by SCH and L-NAME, a NOS inhibitor.	Nitrates	10-17	coagulation factor II, thrombin	Homo sapiens	63-71
26545889-4	2016	After domestication of the bacteria, nitrate (50 mg NO3 (-)-N L(-1)) was completely removed within 3 days in the combined tourmaline-bacteria system, and the generated nitrite was also removed within 8 days.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	52-55
26813102-7	2016	Skeletal muscle biopsies from humans with metabolic syndrome after 12 weeks of oral sodium nitrite and nitrate treatment (IND#115926) displayed increased activation of SIRT3 and AMP-activated protein kinase.	Nitrates	103-110	sirtuin 3	Homo sapiens	168-173
26887919-5	2016	Nitrate treatment increased ABA levels in root tips; this stimulation requires the activity of the endoplasmic reticulum-localized, ABA-GE-deconjugating enzyme b-GLUCOSIDASE1, but not de novo ABA biosynthesis.	Nitrates	0-7	glucosidase 1	Arabidopsis thaliana	162-174
30263239-1	2016	Beetroot is a vegetable rich in nitrate (NO3 -), antioxidants and phenolic compounds that are related to improvements in cardiovascular function and exercise performance.	Nitrates	32-39	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
26904077-3	2016	The reduced nitrate content of Arabidopsis clce mutants suggested a role in regulation of plant nitrate homeostasis.	Nitrates	12-19	chloride channel E	Arabidopsis thaliana	43-47
26904077-3	2016	The reduced nitrate content of Arabidopsis clce mutants suggested a role in regulation of plant nitrate homeostasis.	Nitrates	96-103	chloride channel E	Arabidopsis thaliana	43-47
26564204-2	2016	Bradyrhizobium japonicum, the symbiont of soybeans, can denitrify and grow under free-living conditions with nitrate (NO3 (-)) or nitrite (NO2 (-)) as sole nitrogen source.	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
26724532-3	2016	AIMS: Study prolonged nitrate supplementation on atherogenesis, hypoxia and inflammation in low density lipoprotein receptor knockout mice (LDLr(-/-)).	Nitrates	22-29	low density lipoprotein receptor	Mus musculus	92-124
26614506-1	2016	PURPOSE: This study tested the hypothesis that nitrate (NO3-) supplementation would improve performance during high-intensity intermittent exercise featuring different work and recovery intervals.	Nitrates	47-54	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
26610295-4	2016	In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome.	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	63-66
26610295-4	2016	In this work, we evaluated the potential of exogenous nitrate (NO3(-)) on relieving NO2(-) toxicity, putatively facilitated by NarK, a NO3(-)/NO2(-) transporter encoded in the anammox genome.	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
26493186-9	2016	COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients.	Nitrates	86-94	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
26493186-9	2016	COX-2 and PPAR-gamma inhibition further increased LPS-induced release of nitrites and nitrates in TF explants and adipocytes from OB-CC patients.	Nitrates	86-94	peroxisome proliferator activated receptor gamma	Homo sapiens	10-20
26969547-4	2016	The content of SNA (the sum of sulfate, nitrate, ammonium, SNA) in PM2.5 in Yuzhong County was generally lower than that at other sites in all seasons.	Nitrates	40-47	snail family transcriptional repressor 1	Homo sapiens	15-18
27209746-11	2016	The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg   L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water.	Nitrates	15-22	immunoglobulin kappa variable 1-16	Homo sapiens	142-145
27209746-11	2016	The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg   L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water.	Nitrates	100-107	immunoglobulin kappa variable 1-16	Homo sapiens	142-145
27209746-11	2016	The results of nitrate measurements by the field seawater tests in Yantai coast are obtained, which nitrate concentrations are about 0.2 mg   L-1 in seawater, and the recoveries of samples for standard recovery tests are in 95%~110%, it shows that this system is accurate, reliability and practicability and could be developed for detected nitrate concentration in natural water.	Nitrates	100-107	immunoglobulin kappa variable 1-16	Homo sapiens	142-145
26608644-1	2016	CO2 elevation often alters the plant"s nitrate reductase (NR) activity, the first enzyme acting in the nitrate assimilation pathway.	Nitrates	39-46	nitrate reductase 1	Arabidopsis thaliana	58-60
26608644-5	2016	In response to CO2 elevation, NR activity increased in low-nitrate Col-0 plants but was inhibited in high-nitrate Col-0 plants.	Nitrates	59-66	nitrate reductase 1	Arabidopsis thaliana	30-32
26608644-5	2016	In response to CO2 elevation, NR activity increased in low-nitrate Col-0 plants but was inhibited in high-nitrate Col-0 plants.	Nitrates	106-113	nitrate reductase 1	Arabidopsis thaliana	30-32
26608644-8	2016	Considering all of these findings, this study concluded that, in response to CO2 elevation, either the NR activity induction in low-nitrate plants or the NR activity inhibition in high-nitrate plants is regulated by NOS-generated NO.	Nitrates	132-139	nitrate reductase 1	Arabidopsis thaliana	103-105
26608644-8	2016	Considering all of these findings, this study concluded that, in response to CO2 elevation, either the NR activity induction in low-nitrate plants or the NR activity inhibition in high-nitrate plants is regulated by NOS-generated NO.	Nitrates	185-192	nitrate reductase 1	Arabidopsis thaliana	154-156
26481009-5	2016	Additionally, we found that OsSLAC1 is a nitrate-selective anion channel without obvious permeability to chloride, malate, and sulfate, and the expression of OsSLAC1 in Arabidopsis slac1-3 (atslac1-3) mutant successfully rescued the hypersensitive phenotype of this mutant to drought stress.	Nitrates	41-48	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	181-186
26627858-0	2016	Feeding nitrate and docosahexaenoic acid affects enteric methane production and milk fatty acid composition in lactating dairy cows.	Nitrates	8-15	Weaning weight-maternal milk	Bos taurus	80-84
26627858-14	2016	Milk protein concentration was lower for nitrate-fed cows.	Nitrates	41-48	Weaning weight-maternal milk	Bos taurus	0-4
26481009-6	2016	Together, this research suggests that OsSAPK8 is a counterpart of AtOST1 for the activation of OsSLAC1, which is a nitrate-selective anion channel.	Nitrates	115-122	Protein kinase superfamily protein	Arabidopsis thaliana	66-72
26662603-5	2016	RNA silencing of four of these glutaredoxin genes (AtGRXS3/4/5/8) resulted in plants with increased primary root length (approximately 25% longer than the wild type) and decreased sensitivity to nitrate-mediated inhibition of primary root growth.	Nitrates	195-202	CAX-interacting protein 2	Arabidopsis thaliana	31-43
26662603-7	2016	We determined that nitrate induction of glutaredoxin gene expression was dependent upon cytokinin signaling and that cytokinins could activate glutaredoxin gene expression independent of plant nitrate status.	Nitrates	19-26	CAX-interacting protein 2	Arabidopsis thaliana	40-52
26435258-3	2016	The aim of the study was to measure and correlate plasma nitrite/nitrate levels with tissue specific expression of iNOS mRNA among women with different grades of cervical lesions and cervical cancer.	Nitrates	65-72	nitric oxide synthase 2	Homo sapiens	115-119
26744214-3	2016	The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter).	Nitrates	4-11	nitrate transporter 1.1	Arabidopsis thaliana	128-134
26744214-3	2016	The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter).	Nitrates	4-11	nitrate transporter 1.1	Arabidopsis thaliana	148-154
26744214-3	2016	The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter).	Nitrates	4-11	NITRATE TRANSPORTER 1.8	Arabidopsis thaliana	217-223
26744214-3	2016	The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter).	Nitrates	4-11	NITRATE TRANSPORTER 1.8	Arabidopsis thaliana	237-243
26744214-4	2016	Genetic and molecular data suggest that NRG2 functions upstream of NRT1.1 in nitrate signaling.	Nitrates	77-84	nitrate transporter 1.1	Arabidopsis thaliana	67-73
26744214-5	2016	Furthermore, NRG2 directly interacts with the nitrate regulator NLP7 in the nucleus, but nuclear retention of NLP7 in response to nitrate is not dependent on NRG2.	Nitrates	46-53	NIN like protein 7	Arabidopsis thaliana	64-68
26744214-5	2016	Furthermore, NRG2 directly interacts with the nitrate regulator NLP7 in the nucleus, but nuclear retention of NLP7 in response to nitrate is not dependent on NRG2.	Nitrates	130-137	NIN like protein 7	Arabidopsis thaliana	110-114
26744214-8	2016	Thus, NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.	Nitrates	31-38	nitrate transporter 1.1	Arabidopsis thaliana	77-81
26437351-1	2016	Nitrate (NO3) is one of the most common contaminants in aquatic environments and groundwater.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
26631727-1	2016	Nitrate (NO3(-)) and nitrite (NO2(-)) are the physiological sources of nitric oxide (NO), a key biological messenger molecule.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
26834770-8	2015	Transcriptional analysis of ZmXET1 confirmed the stimulatory effect of nitrate on XGs accumulation in cells of the TZ.	Nitrates	71-78	xyloglucan endotransglycosylase homolog 1	Zea mays	28-34
26607938-8	2016	Dietary nitrate also caused a small but significant reduction (7.6%) in platelet-monocyte aggregates compared with an increase of 10.1% in the placebo group (P = 0.004), with statistically significant reductions in stimulated (ex vivo) P-selectin expression compared with the placebo group (P &lt; 0.05) but no significant changes in unstimulated expression.	Nitrates	8-15	selectin P	Homo sapiens	236-246
26547269-4	2016	The denitrification rates using optimal carbon-to-nitrate ratios of acidogenic liquid were more than 25 mg NO3-N/(gVSS h).	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
27526131-5	2016	Acidotic conditions for up to 6 h increased the iNOS expression significantly which was functional as indicated by an elevated level of nitrate/nitrite formation by 30 %.	Nitrates	136-143	nitric oxide synthase 2, inducible	Mus musculus	48-52
27458036-6	2016	XOR has an activating role that is essential to the pharmacological action of quinone drugs, cyadox, antiviral nucleoside analogues, allopurinol, nitrate and nitrite.	Nitrates	146-153	xanthine dehydrogenase	Homo sapiens	0-3
26335529-7	2016	The results of an ANOVA and response surface analysis showed that HRT, influent NO3 (-)-N concentration, influent CODCr concentration, and the interaction between the HRT and influent CODCr concentration significantly affected the nitrate removal efficiency (P &lt; 0.05).	Nitrates	231-238	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
26681182-7	2016	Dissolved inorganic nitrogen (DIN) in S2 mainly comprised ammonium (NH4 (+)), while nitrate (NO3 (-)) predominated in S1.	Nitrates	84-91	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
25811939-10	2016	Spring water sections within the high mountains contain nitrate in low concentrations with low delta(15)NNO3 values of -3 % and high delta(18)ONO3 values up to 13 %.	Nitrates	56-63	NNO3	Homo sapiens	104-108
26074023-5	2016	Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1.	Nitrates	62-69	superoxide dismutase 3	Homo sapiens	170-176
26074023-5	2016	Several PM2.5 chemical constituents, including negative ions (nitrate and chloride) and metals (e.g., iron and strontium), were consistently associated with increases in EC-SOD and GPX1.	Nitrates	62-69	glutathione peroxidase 1	Homo sapiens	181-185
25811939-11	2016	High mountain stream water sub-catchments dominated by nearly undisturbed forest and grassland contribute nitrate with delta(15)NNO3 and delta(18)ONO3 values of -1 and -3.5 %, respectively.	Nitrates	106-113	NNO3	Homo sapiens	128-132
25923308-2	2016	In this study, we report the assimilation and utilization of nitrate luxuriant levels, 20 times more than the highest N fertilizer application in Europe, by transgenic poplars overexpressing a cytosolic glutamine synthetase (GS1).	Nitrates	61-68	pseudouridine 5'-phosphatase	Homo sapiens	225-228
27018849-5	2016	Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism.	Nitrates	14-21	pyridoxin (pyrodoxamine) 5'-phosphate oxidase	Arabidopsis thaliana	60-64
27049601-0	2016	The AtGRXS3/4/5/7/8 glutaredoxin gene cluster on Arabidopsis thaliana chromosome 4 is coordinately regulated by nitrate and appears to control primary root growth.	Nitrates	112-119	CAX-interacting protein 2	Arabidopsis thaliana	20-32
27049601-2	2016	We previously identified a group of class III glutaredoxin genes whose expression is strongly upregulated by nitrate, but not ammonium, in Arabidopsis thaliana shoots and roots.	Nitrates	109-116	CAX-interacting protein 2	Arabidopsis thaliana	46-58
27049601-5	2016	Interestingly, there is one additional glutaredoxin, AtGRXS7, in this same gene cluster, but this gene was not identified as nitrate-responsive in our previous studies.	Nitrates	125-132	CAX-interacting protein 2	Arabidopsis thaliana	39-51
26562799-7	2016	Stable isotope data reveal nutrient inputs to the river upstream of the waste water treatment works that are consistent with partially denitrified sewage or livestock sources of nitrate (delta(15)NNO3 range = +11.5 to +13.1%) and with agricultural sources of phosphate (delta(18)OPO4 range = +16.6 to +19.0%).	Nitrates	178-185	NNO3	Homo sapiens	196-200
27717924-10	2016	CONCLUSIONS: the combined effect of nitrate and sodium fluoride for 30 days leads to disregulatory increased activity of NO-synthase enzymes and reduction of arginase pathway of L-arginine in the soft tissues of parodontium that is promoted by hyperactivation of iNOS and NF-kappaB, and increased peroxynitrite production.	Nitrates	36-43	nitric oxide synthase 2	Rattus norvegicus	263-267
27508376-5	2016	Ammonium removal rate was up to 95% in biofilters with or without electrolysis integration with an influent ammonium concentration of 40 mg/L, and the accumulation of nitrate and nitrite was much lower in the effluent of E-BF than that of BF.	Nitrates	167-174	EBF transcription factor 1	Homo sapiens	221-225
26577172-4	2015	The nitrate salts fall into three groups based on their observed rate of NO2 formation (R(NO2)): (1) RbNO3 and KNO3, which readily produce NO2 (R(NO2) &gt; 3 ppb min(-1)), (2) Ca(NO3)2, which produces NO2 more slowly (R(NO2) &lt; 1 ppb min(-1)), and (3) Mg(NO3)2 and NaNO3, which lie between the other two groups.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
28478405-10	2016	CONCLUSIONS: the combined effect of nitrate and sodium fluoride for 30 days leads to disregulatory increased activity of NO-synthase enzymes and reduction of arginase pathway of L-arginine in the soft tissues of parodontium that is promoted by hyperactivation of iNOS and NF-kappaB, and increased peroxynitrite production.	Nitrates	36-43	nitric oxide synthase 2	Rattus norvegicus	263-267
26577172-4	2015	The nitrate salts fall into three groups based on their observed rate of NO2 formation (R(NO2)): (1) RbNO3 and KNO3, which readily produce NO2 (R(NO2) &gt; 3 ppb min(-1)), (2) Ca(NO3)2, which produces NO2 more slowly (R(NO2) &lt; 1 ppb min(-1)), and (3) Mg(NO3)2 and NaNO3, which lie between the other two groups.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
26694920-0	2015	Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism.	Nitrates	0-7	peroxisome proliferator activated receptor alpha	Mus musculus	78-82
26694920-6	2015	We show that nitrate induces FA oxidation through a soluble guanylate cyclase (sGC)/cGMP-mediated PPARbeta/delta- and PPARalpha-dependent mechanism.	Nitrates	13-20	peroxisome proliferator activated receptor alpha	Mus musculus	84-127
26549233-0	2015	The calcium sensor CBL7 modulates plant responses to low nitrate in Arabidopsis.	Nitrates	57-64	calcineurin B-like protein 7	Arabidopsis thaliana	19-23
26733879-3	2015	Interestingly, the first cloned nitrate transporter in Arabidopsis, NRT1.1 functions as a dual-affinity transporter, which can change its affinity for nitrate in response to substrate availability.	Nitrates	32-39	nitrate transporter 1.1	Arabidopsis thaliana	68-74
26549233-4	2015	Here, we report that CBL7 is involved in the regulation of low-nitrate response in Arabidopsis.	Nitrates	63-70	calcineurin B-like protein 7	Arabidopsis thaliana	21-25
26549233-5	2015	Expression of CBL7 was predominant in the root of young seedlings and substantially induced by nitrate starvation.	Nitrates	95-102	calcineurin B-like protein 7	Arabidopsis thaliana	14-18
26549233-6	2015	Cbl7 mutant was more inhibited in root growth upon nitrate starvation compared to the wild-type.	Nitrates	51-58	calcineurin B-like protein 7	Arabidopsis thaliana	0-4
26549233-7	2015	Interestingly, the growth arrest of cbl7 under low-nitrate conditions relied on acidic pH.	Nitrates	51-58	calcineurin B-like protein 7	Arabidopsis thaliana	36-40
26549233-9	2015	Accordingly, the cbl7 mutant plants retained lower nitrate content than wild-type plants under low-nitrate condition.	Nitrates	51-58	calcineurin B-like protein 7	Arabidopsis thaliana	17-21
26549233-9	2015	Accordingly, the cbl7 mutant plants retained lower nitrate content than wild-type plants under low-nitrate condition.	Nitrates	99-106	calcineurin B-like protein 7	Arabidopsis thaliana	17-21
26549233-10	2015	Taken together, our results uncover a novel role of CBL7 in the response to nitrate deficiency in Arabidopsis.	Nitrates	76-83	calcineurin B-like protein 7	Arabidopsis thaliana	52-56
26338830-1	2015	PURPOSE: Dietary nitrate (NO3 (-)) supplementation reduces the O2 cost of fixed-workload tasks performed in temperate environments but has not been examined in the heat.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
26815943-8	2015	The results showed that the nitrate (NO3-), NO2-, TSS, turbidity and total phosphorous (TP) levels were related to the soil type, and the parameters DO, electrical conductivity (EC), ammoniacal nitrogen (N-NH3) and thermotolerant coliforms (TC) were related to organic matter pollution, with the P5 sampling site being the most critical site.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
26385079-1	2015	A gap in our understanding of the beneficial systemic responses to dietary constituents nitrate (NO3(-)), nitrite (NO2(-)) and conjugated linoleic acid (cLA) is the identification of the downstream metabolites that mediate their actions.	Nitrates	88-95	NBL1, DAN family BMP antagonist	Homo sapiens	97-100
26297074-3	2015	We hypothesized that (H1) soil nitrate (NO3 (-) ) is elevated nearer to the urban core, reflecting N deposition gradients.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
26508776-0	2015	Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	56-76
26346778-0	2015	G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.	Nitrates	49-56	G protein alpha subunit 1	Arabidopsis thaliana	0-23
26346778-0	2015	G-protein alpha-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana.	Nitrates	49-56	G protein alpha subunit 1	Arabidopsis thaliana	25-29
26346778-4	2015	We found 394 GPA1-regulated genes spanning 79 biological processes, including biotic and abiotic stresses, development, flavonoid biosynthesis, transcription factors, transporters and nitrate/phosphate responses.	Nitrates	184-191	G protein alpha subunit 1	Arabidopsis thaliana	13-17
26508776-0	2015	Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	118-122
26508776-0	2015	Nitrate-Dependent Control of Shoot K Homeostasis by the Nitrate Transporter1/Peptide Transporter Family Member NPF7.3/NRT1.5 and the Stelar K+ Outward Rectifier SKOR in Arabidopsis.	Nitrates	0-7	STELAR K+ outward rectifier	Arabidopsis thaliana	161-165
26605044-2	2015	In this nitrogen removal process, a complete biological denitrification from nitrate (NO3 (-)) to molecular nitrogen (N2) was achieved by four reduction steps, forming nitrite (NO2 (-)), nitric oxide (NO) and nitrous oxide (N2O) as intermediate compounds.	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
26094110-3	2015	Nitrate (NO3) concentrations in runoff from semi-natural catchments typically show an annual cycle, with low concentrations during the summer and high concentrations during the winter.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
26364226-2	2015	The nitrate removal rates obtained in the methanol- and ethanol-fed mixotrophic denitrifying AnFB-MBRs reached 1.44-3.84 g NO3 -N/L reactor d at a hydraulic retention time of 0.5 h, which were significantly superior to those reported in packed bed reactors.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
26635847-3	2015	A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport.	Nitrates	52-59	nitrate transporter 1.1	Arabidopsis thaliana	134-140
26635847-3	2015	A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport.	Nitrates	144-151	nitrate transporter 1.1	Arabidopsis thaliana	134-140
26635847-3	2015	A connection between changes in auxin transport and nitrate signal transduction has been reported in Arabidopsis thaliana through the NRT1.1, a nitrate sensor and transporter that also functions as a repressor of lateral root growth under low concentrations of nitrate by promoting auxin transport.	Nitrates	144-151	nitrate transporter 1.1	Arabidopsis thaliana	134-140
26151563-7	2015	After adjustment for multiple comparisons using an overall 0.05 level of type I error, the distribution of nitrate penetration values was found to differ significantly among all groups with the exception of DayWhite (median: 10.72 muM) and UltraEZ (median: 9.22 muM), which differed significantly from other groups but not from each other.	Nitrates	107-114	latexin	Homo sapiens	262-265
26325324-1	2015	INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
26325324-1	2015	INTRODUCTION: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO2-) and nitric oxide (NO) through the NO3- - NO2- - NO pathway, and may improve vascular functions during normoxia.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
26151563-8	2015	The highest levels of nitrate penetration value were observed for PreviDent (median: 27.61 muM) followed by Relief ACP (median: 19.64 muM).	Nitrates	22-29	latexin	Homo sapiens	91-94
26151563-8	2015	The highest levels of nitrate penetration value were observed for PreviDent (median: 27.61 muM) followed by Relief ACP (median: 19.64 muM).	Nitrates	22-29	latexin	Homo sapiens	134-137
26371233-0	2015	The Nitrate-Inducible NAC Transcription Factor TaNAC2-5A Controls Nitrate Response and Increases Wheat Yield.	Nitrates	4-11	NAC domain-containing protein 2	Triticum aestivum	47-53
26310141-3	2015	Here we report the differential regulation of expression of POLYAMINE OXIDASE2 of Arabidopsis (AtPAO2) in interaction with ABA, nitrate and ammonium.	Nitrates	128-135	polyamine oxidase 2	Arabidopsis thaliana	60-78
26310141-3	2015	Here we report the differential regulation of expression of POLYAMINE OXIDASE2 of Arabidopsis (AtPAO2) in interaction with ABA, nitrate and ammonium.	Nitrates	128-135	polyamine oxidase 2	Arabidopsis thaliana	95-101
26371233-0	2015	The Nitrate-Inducible NAC Transcription Factor TaNAC2-5A Controls Nitrate Response and Increases Wheat Yield.	Nitrates	66-73	NAC domain-containing protein 2	Triticum aestivum	47-53
26371233-3	2015	Here, we isolated a nitrate-inducible and cereal-specific NAM, ATAF, and CUC (NAC) transcription factor, TaNAC2-5A, from wheat (Triticum aestivum).	Nitrates	20-27	NAC domain-containing protein 2	Triticum aestivum	105-111
26371233-5	2015	Overexpression of TaNAC2-5A in wheat enhanced root growth and nitrate influx rate and, hence, increased the root"s ability to acquire nitrogen.	Nitrates	62-69	NAC domain-containing protein 2	Triticum aestivum	18-24
26371233-7	2015	These results suggest that TaNAC2-5A is involved in nitrate signaling and show that it is an exciting gene resource for breeding crops with more efficient use of fertilizer.	Nitrates	52-59	NAC domain-containing protein 2	Triticum aestivum	27-33
26276822-2	2015	In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis.	Nitrates	192-199	nitric oxide synthase 3, endothelial cell	Mus musculus	85-118
26412597-2	2015	A sampling of structures in which the nitrate ion is solvated by 32 water molecules is optimized using second order Moller-Plesset perturbation theory (MP2).	Nitrates	38-45	tryptase pseudogene 1	Homo sapiens	152-155
26276822-2	2015	In mice, ART-induced vascular dysfunction is related to epigenetic alteration of the endothelial nitric oxide synthase (eNOS) gene, resulting in decreased vascular eNOS expression and nitrite/nitrate synthesis.	Nitrates	192-199	nitric oxide synthase 3, endothelial cell	Mus musculus	120-124
26335797-0	2015	Interaction of Yna1 and Yna2 Is Required for Nuclear Accumulation and Transcriptional Activation of the Nitrate Assimilation Pathway in the Yeast Hansenula polymorpha.	Nitrates	104-111	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	15-19
26231655-6	2015	Nitrate concentrations declined from a high of 25 muM upgradient and adjacent to the barrier to &lt;0.1 muM within the PRB.	Nitrates	0-7	RB transcriptional corepressor 1	Homo sapiens	119-122
26304850-10	2015	Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes.	Nitrates	127-134	nitrate transporter 1.1	Arabidopsis thaliana	34-38
26304850-10	2015	Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes.	Nitrates	127-134	nitrate transporter 1.1	Arabidopsis thaliana	41-49
26304850-10	2015	Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes.	Nitrates	186-193	nitrate transporter 1.1	Arabidopsis thaliana	34-38
26304850-10	2015	Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activity mediate the increase of Ca(2+) in response to nitrate required for changes in expression of prototypical nitrate-responsive genes.	Nitrates	186-193	nitrate transporter 1.1	Arabidopsis thaliana	41-49
26335797-2	2015	The genes necessary for nitrate assimilation are organised in this organism as a cluster comprising those encoding nitrate reductase (YNR1), nitrite reductase (YNI1), a high affinity transporter (YNT1), as well as the two pathway specific Zn(II)2Cys2 transcriptional activators (YNA1, YNA2).	Nitrates	24-31	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	279-283
26335797-4	2015	Yna1p activates YNA2 as well as its own (YNA1) transcription thus forming a nitrate-dependent autoactivation loop.	Nitrates	76-83	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	41-45
26084693-1	2015	While acute treatment with beetroot juice (BRJ) containing nitrate (NO3 (-)) can lower systolic blood pressure (SBP), afterload, and myocardial O2 demand during submaximal exercise, effects of chronic supplementation with BRJ (containing a relatively low dose of NO3 (-), 400 mg) on cardiac output (CO), SBP, total peripheral resistance (TPR), and the work of the heart in response to dynamic exercise are not known.	Nitrates	59-66	NBL1, DAN family BMP antagonist	Homo sapiens	68-71
25846114-1	2015	UNLABELLED: It is possible that dietary nitrate (NO3 (-)) supplementation may improve both physical and cognitive performance via its influence on blood flow and cellular energetics.	Nitrates	40-47	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
25324021-5	2015	The crop field was responsible for 96% of the total nitrate loading (16.2 t NO3 /year) to the lake even though the field only covered 4.5% of the catchment area.	Nitrates	52-59	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
25943519-1	2015	A laboratory column experiment was conducted to test the efficiency of denitrifying bioreactors for the nitrate (NO3-N) removal in drainage waters at different flow rates and after desiccation.	Nitrates	104-111	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
26300787-0	2015	In adenosine A2B knockouts acute treatment with inorganic nitrate improves glucose disposal, oxidative stress, and AMPK signaling in the liver.	Nitrates	58-65	adenosine A2b receptor	Mus musculus	13-16
26008190-8	2015	The nitrate sensitivity was reduced at mM concentrations in a loss-of-function mutant of the nitrate transporter and sensor gene NRT1;1 (NPF6.3).	Nitrates	4-11	nitrate transporter 1.1	Arabidopsis thaliana	129-133
26347655-7	2015	It is proposed that CuB delivers superoxide to NO bound to Fe-heme forming peroxynitrite, then nitrate that diffuses away.	Nitrates	95-102	rhomboid 5 homolog 2	Mus musculus	20-23
26258667-2	2015	ANR1 was reported to play a key role in controlling lateral root development through nitrate signal in Arabidopsis.	Nitrates	85-92	AGAMOUS-like 44	Arabidopsis thaliana	0-4
24224525-1	2015	AIMS: Inorganic nitrate and nitrite from endogenous and dietary sources have emerged as alternative substrates for nitric oxide (NO) formation in addition to the classic L-arginine NO synthase (NOS)-dependent pathway.	Nitrates	16-23	nitric oxide synthase 1, neuronal	Mus musculus	181-192
25474587-0	2015	A 150 kDa plasma membrane complex of AtNRT2.5 and AtNAR2.1 is the major contributor to constitutive high-affinity nitrate influx in Arabidopsis thaliana.	Nitrates	114-121	nitrate transporter2.5	Arabidopsis thaliana	37-45
25937621-1	2015	It is now recognised that administration of oral nitrate (NO3(-)), in its various forms, increases the level of nitric oxide (NO) metabolites in the circulation of humans.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
26321266-3	2015	Despite this long standing association between increased vascular XOR activity and negative clinical outcomes, recent reports reveal a new paradigm whereby the enzymatic activity of XOR mediates beneficial outcomes by catalyzing the one electron reduction of nitrite (NO2(-)) to nitric oxide (NO) when NO2(-) and/or nitrate (NO3(-)) levels are enhanced either via dietary or pharmacologic means.	Nitrates	316-323	xanthine dehydrogenase	Homo sapiens	182-185
26068891-9	2015	Nitrate supplementation was associated with improved insulin response, decreased plasma IL-10 and a trend towards improved survival.	Nitrates	0-7	interleukin 10	Mus musculus	88-93
26163808-3	2015	LPS-stimulated iNOS and NADPH oxidase (Nox) activity in RAW 264.7 murine macrophages was assessed by measuring cellular nitrate and superoxide ( [Formula: see text] ) production, respectively.	Nitrates	120-127	nitric oxide synthase 2, inducible	Mus musculus	15-19
26163808-4	2015	The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent.	Nitrates	23-30	toll-like receptor 4	Mus musculus	92-96
26163808-4	2015	The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent.	Nitrates	23-30	nitric oxide synthase 2, inducible	Mus musculus	139-143
26163808-4	2015	The generation of both nitrate and [Formula: see text] in response to LPS was suppressed by TLR4 inhibitors, indicating that activation of iNOS and Nox is TLR4-dependent.	Nitrates	23-30	toll-like receptor 4	Mus musculus	155-159
25474587-4	2015	We demonstrate that AtNRT2.5 is predominantly expressed in roots of nitrate-deprived WT plants as a 150 kDa molecular complex with AtNAR2.1.	Nitrates	68-75	nitrate transporter2.5	Arabidopsis thaliana	20-28
25474587-6	2015	The remaining cHATS nitrate influx in these mutants is due to a residual contribution by the inducible high-affinity transporter encoded by AtNRT2.1/AtNAR2.1.	Nitrates	20-27	nitrate transporter 2:1	Arabidopsis thaliana	140-148
25474587-7	2015	Estimates of the kinetic properties of the NRT2.5 transporter reveal that its low Km for nitrate makes this transporter ideally suited to detect and respond to trace quantities of nitrate in the root environment.	Nitrates	89-96	nitrate transporter 2:1	Arabidopsis thaliana	43-47
25474587-7	2015	Estimates of the kinetic properties of the NRT2.5 transporter reveal that its low Km for nitrate makes this transporter ideally suited to detect and respond to trace quantities of nitrate in the root environment.	Nitrates	180-187	nitrate transporter 2:1	Arabidopsis thaliana	43-47
26197322-2	2015	This paper describes a low-cost, compact, and scalable nitrate sensor based on electrochemical impedance spectroscopy for monitoring trace amounts of NO3- in selected growing media.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	150-153
25869522-0	2015	Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats.	Nitrates	93-100	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	10-34
25869522-7	2015	sGC activator therapy improves partially the adverse effects of nitroglycerin therapy whereas sGC stimulation has only minor beneficial effects pointing to a nitroglycerin-dependent sGC oxidation/inactivation mechanism contributing to nitrate tolerance.	Nitrates	235-242	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	0-3
26151723-1	2015	We present a novel approach for nitrogen (delta(15)N) and oxygen (delta(18)O) isotopic analysis of nitrate in water based on the isotopic analysis of N2O produced from the conversion of NO3(-) by cultured denitrifying bacteria and off-axis integrated cavity output spectroscopy (OA-ICOS).	Nitrates	99-106	inducible T cell costimulator	Homo sapiens	282-286
26151723-3	2015	Sample analysis time was ~300 s. The use of OA-ICOS technology yields accurate and precise delta(15)N and delta(18)O results for dissolved nitrate samples when nonlinearity issues are considered.	Nitrates	139-146	inducible T cell costimulator	Homo sapiens	47-51
25902041-4	2015	Data from 832 human subjects revealed that heterozygous and homozygous Arg972 IRS-1 carriers had significantly lower levels of plasma eNOS and nitrite/nitrate than the homozygous wild-type (WT) IRS-1 carriers.	Nitrates	151-158	insulin receptor substrate 1	Homo sapiens	78-83
25940469-1	2015	Nitrate (NO3(-)) contamination of freshwater is considered one of the most prevalent global environmental problems.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25902041-9	2015	On the whole, our in vivo data demonstrate that Arg972 IRS-1 is associated with decreased plasma eNOS and nitrite/nitrate levels in human subjects.	Nitrates	114-121	insulin receptor substrate 1	Homo sapiens	48-60
26057801-2	2015	THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1.	Nitrates	70-77	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26091235-3	2015	Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer.	Nitrates	100-107	insulin	Homo sapiens	172-179
26057801-2	2015	THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1.	Nitrates	70-77	uncharacterized protein	Chlamydomonas reinhardtii	40-44
26057801-2	2015	THB1 expression is under the control of NIT2, the master regulator of nitrate assimilation, which also controls the expression of the only nitrate reductase in the cell, NIT1.	Nitrates	70-77	uncharacterized protein	Chlamydomonas reinhardtii	170-174
26057801-3	2015	In vitro and physiological evidence suggests that THB1 converts the nitric oxide generated by NIT1 into nitrate.	Nitrates	104-111	uncharacterized protein	Chlamydomonas reinhardtii	50-54
26057801-3	2015	In vitro and physiological evidence suggests that THB1 converts the nitric oxide generated by NIT1 into nitrate.	Nitrates	104-111	uncharacterized protein	Chlamydomonas reinhardtii	94-98
25700865-1	2015	This work presents a novel electrochemical assay for the collective measurement of nitric oxide (NO) and its metabolites nitrite (NO2(-)) and nitrate (NO3(-)) in volume miniaturized sample at low cost using copper(II) chlorophyllin (CuCP) modified sensor electrode.	Nitrates	142-149	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
25826741-7	2015	Nitrate supplementation has been shown to increase NO-dependent vasodilatation through both NO synthase (NOS)-dependent and NOS-independent pathways.	Nitrates	0-7	nitric oxide synthase 2	Homo sapiens	92-103
25694484-6	2015	ANG II also increased renal production of ROS and urinary excretion of thiobarburic acid-reactive substances and reduced the activity of antioxidants and urinary excretion of nitrite/nitrate and the 17beta-estradiol metabolite 2-methoxyestradiol in Cyp1b1(-/-) but not Cyp1b1(+/+) mice.	Nitrates	183-190	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
24990704-8	2015	The following predictors were found to be associated with EPO prescription: iron supplementation (odds ratio [OR] 52.70, 95% confidence interval [CI] 11.70-237.46), renal clinic appointment (OR 2.60, 95% CI 1.79-3.76), malignancy (OR 1.52, 95% CI 1.07-2.16) and use of hydralazine/nitrates (OR 1.41, 95% CI 1.03-1.92).	Nitrates	281-289	erythropoietin	Homo sapiens	58-61
25991919-1	2015	BACKGROUND AND AIM: The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recently raised the hypothesis that inorganic nitrate and nitrite could be potential therapeutic agents in type 2 diabetes.	Nitrates	45-52	insulin	Homo sapiens	190-197
25991919-1	2015	BACKGROUND AND AIM: The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recently raised the hypothesis that inorganic nitrate and nitrite could be potential therapeutic agents in type 2 diabetes.	Nitrates	268-275	insulin	Homo sapiens	190-197
25661464-0	2015	[Nitrate concentrations in tap water in Spain].	Nitrates	1-8	nuclear RNA export factor 1	Homo sapiens	27-30
25943353-0	2015	Nitrate sensing and uptake in Arabidopsis are enhanced by ABI2, a phosphatase inactivated by the stress hormone abscisic acid.	Nitrates	0-7	Protein phosphatase 2C family protein	Arabidopsis thaliana	58-62
25943353-4	2015	NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana.	Nitrates	52-59	nitrate transporter 1.1	Arabidopsis thaliana	22-28
25943353-4	2015	NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	22-28
25943353-4	2015	NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana.	Nitrates	166-173	CBL-interacting protein kinase 23	Arabidopsis thaliana	95-101
25943353-4	2015	NPF6.3 (also known as NRT1.1), which functions as a nitrate sensor and transporter; the kinase CIPK23; and the calcium sensor CBL9 form a complex that is crucial for nitrate sensing in Arabidopsis thaliana.	Nitrates	166-173	calcineurin B-like protein 9	Arabidopsis thaliana	126-130
25943353-5	2015	We identified two additional components that regulate nitrate transport, sensing, and signaling: the calcium sensor CBL1 and protein phosphatase 2C family member ABI2, which is inhibited by the stress-response hormone abscisic acid.	Nitrates	54-61	calcineurin B-like protein 1	Arabidopsis thaliana	116-120
25943353-5	2015	We identified two additional components that regulate nitrate transport, sensing, and signaling: the calcium sensor CBL1 and protein phosphatase 2C family member ABI2, which is inhibited by the stress-response hormone abscisic acid.	Nitrates	54-61	Protein phosphatase 2C family protein	Arabidopsis thaliana	162-166
25943353-7	2015	Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling.	Nitrates	127-134	abl-interactor 2 S homeolog	Xenopus laevis	76-80
25943353-7	2015	Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling.	Nitrates	127-134	abl-interactor 2 S homeolog	Xenopus laevis	96-100
25943353-7	2015	Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling.	Nitrates	146-153	abl-interactor 2 S homeolog	Xenopus laevis	96-100
25943353-7	2015	Coexpression studies in Xenopus oocytes and analysis of plants deficient in ABI2 indicated that ABI2 enhanced NPF6.3-dependent nitrate transport, nitrate sensing, and nitrate signaling.	Nitrates	146-153	abl-interactor 2 S homeolog	Xenopus laevis	96-100
25943353-8	2015	These findings suggest that ABI2 may functionally link stress-regulated control of growth and nitrate uptake and utilization, which are energy-expensive processes.	Nitrates	94-101	Protein phosphatase 2C family protein	Arabidopsis thaliana	28-32
25727730-9	2015	Nitrate levels in skeletal muscle and blood in nNOS(-/-) mice were dramatically lower when compared with controls, which support further our hypothesis.	Nitrates	0-7	nitric oxide synthase 1, neuronal	Mus musculus	47-51
25917853-9	2015	CONCLUSIONS: Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates.	Nitrates	167-175	nitric oxide synthase 3	Homo sapiens	50-54
25819437-0	2015	LeNRT2.3 functions in nitrate acquisition and long-distance transport in tomato.	Nitrates	22-29	nitrate transporter NRT2.3	Solanum lycopersicum	0-8
25819437-3	2015	In this study, we report the functions of LeNRT2.3 in nitrate transport in tomato.	Nitrates	54-61	nitrate transporter NRT2.3	Solanum lycopersicum	42-50
25819437-4	2015	Our results show that LeNRT2.3 is induced by nitrate, and mainly localizes to the plasma membranes of rhizodermal and pericycle cells in roots.	Nitrates	45-52	nitrate transporter NRT2.3	Solanum lycopersicum	22-30
25819437-5	2015	Further analysis in Xenopus oocytes showed that LeNRT2.3 mediates low-affinity nitrate transport.	Nitrates	79-86	nitrate transporter NRT2.3	Solanum lycopersicum	48-56
25819437-6	2015	35S:LeNRT2.3 increased nitrate uptake in root and transport from root to shoot.	Nitrates	23-30	nitrate transporter NRT2.3	Solanum lycopersicum	4-12
25819437-8	2015	Taken together, these results suggest that LeNRT2.3 plays a double role in nitrate uptake and long-distance transport in tomato.	Nitrates	75-82	nitrate transporter NRT2.3	Solanum lycopersicum	43-51
25727730-10	2015	Although the nitrate reductase activity of xanthine oxidoreductase in muscle is less than that of liver, the residual activity in muscle could be very important in view of its total mass and the high basal level of nitrate.	Nitrates	13-20	xanthine dehydrogenase	Homo sapiens	43-66
25659431-0	2015	Mycobacterium tuberculosis response regulators, DevR and NarL, interact in vivo and co-regulate gene expression during aerobic nitrate metabolism.	Nitrates	127-134	nitrate/nitrite response transcriptional regulator NarL	Mycobacterium tuberculosis H37Rv	57-61
25772087-1	2015	Highly oxidizing nitrate radicals (NO3 ) are easily accessed from readily available nitrate salts by visible light photoredox catalysis using a purely organic dye as the catalyst and oxygen as the terminal oxidant.	Nitrates	84-97	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
25772087-2	2015	The interaction of the excited catalyst and nitrate anions was studied by spectroscopic methods to elucidate the mechanism, and the method was applied to the NO3  induced oxidation of alkynes and alcohols.	Nitrates	44-51	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
25849210-1	2015	Ecologists have found a close relationship between the concentrations of nitrate (NO3-) and dissolved organic carbon (DOC) in ecosystems.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
25303373-8	2015	Furthermore, chronic treatment of these patients with drugs like ACE inhibitors, statins and nitrates may modify signalling, inhibiting the protective effect of postconditioning mimetics, or conversely induce a maximally protected state wherein no further benefit can be demonstrated.	Nitrates	93-101	angiotensin I converting enzyme	Homo sapiens	65-68
26164890-6	2015	Sulfate mainly existed in fine particle in the forms of (NH4)2SO4 and K2SO4, while nitrate mainly existed in coarse particle in the form of Mg(NO3)2.	Nitrates	83-90	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
25659431-1	2015	Mycobacterium tuberculosis genes Rv0844c/Rv0845 encoding the NarL response regulator and NarS histidine kinase are hypothesized to constitute a two-component system involved in the regulation of nitrate metabolism.	Nitrates	195-202	nitrate/nitrite response transcriptional regulator NarL	Mycobacterium tuberculosis H37Rv	61-65
25659431-4	2015	Transcriptional profiling between M. tuberculosis H37Rv and a DeltanarL mutant strain during exponential growth in broth cultures with or without nitrate defined an ~30-gene NarL regulon that exhibited significant overlap with DevR-regulated genes, thereby implicating a role for the DevR response regulator in the regulation of nitrate metabolism.	Nitrates	146-153	nitrate/nitrite response transcriptional regulator NarL	Mycobacterium tuberculosis H37Rv	174-178
27246882-0	2015	Multiple mechanisms of nitrate sensing by Arabidopsis nitrate transceptor NRT1.1.	Nitrates	23-30	nitrate transporter 1.1	Arabidopsis thaliana	74-80
25683572-1	2015	When oxygen is limiting in soils and sediments, microorganisms utilize nitrate (NO3-) in respiration--through the process of denitrification--leading to the production of dinitrogen (N2) gas and trace amounts of nitrous (N2O) and nitric (NO) oxides.	Nitrates	71-78	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
25695878-8	2015	The computed structure of PuO3(NO3)2(-) is essentially a plutonyl(VI) core, Pu(VI)O2(2+), coordinated in the equatorial plane by two nitrate ligands and one radical oxygen atom.	Nitrates	133-140	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
27246882-1	2015	In Arabidopsis the plasma membrane nitrate transceptor (transporter/receptor) NRT1.1 governs many physiological and developmental responses to nitrate.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	78-82
27246882-1	2015	In Arabidopsis the plasma membrane nitrate transceptor (transporter/receptor) NRT1.1 governs many physiological and developmental responses to nitrate.	Nitrates	143-150	nitrate transporter 1.1	Arabidopsis thaliana	78-82
27246882-2	2015	Alongside facilitating nitrate uptake, NRT1.1 regulates the expression levels of many nitrate assimilation pathway genes, modulates root system architecture, relieves seed dormancy and protects plants from ammonium toxicity.	Nitrates	23-30	nitrate transporter 1.1	Arabidopsis thaliana	39-43
27246882-2	2015	Alongside facilitating nitrate uptake, NRT1.1 regulates the expression levels of many nitrate assimilation pathway genes, modulates root system architecture, relieves seed dormancy and protects plants from ammonium toxicity.	Nitrates	86-93	nitrate transporter 1.1	Arabidopsis thaliana	39-43
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	100-107	nitrate transporter 1.1	Arabidopsis thaliana	70-74
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	100-107	nitrate transporter 2:1	Arabidopsis thaliana	249-255
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	70-74
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 2:1	Arabidopsis thaliana	249-255
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	70-74
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 2:1	Arabidopsis thaliana	249-255
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	70-74
27246882-4	2015	We show that the point mutations differentially affect several of the NRT1.1-dependent responses to nitrate, namely the repression of lateral root development at low nitrate concentrations, and the short-term upregulation of the nitrate-uptake gene NRT2.1, and its longer-term downregulation, at high nitrate concentrations.	Nitrates	166-173	nitrate transporter 2:1	Arabidopsis thaliana	249-255
27246882-7	2015	In particular, we present evidence to suggest that the phosphorylated and non-phosphorylated forms of NRT1.1 at T101 have distinct signalling functions, and that the nitrate-dependent regulation of root development depends on the phosphorylated form.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	102-106
25688692-6	2015	Nitrate reduction activity, the first step in the denitrification process, was recorded for isolates under simulated anoxic, deep-sea conditions showing ecological significance of fungi in the oxygen-depleted habitats.	Nitrates	0-7	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	130-133
25343972-2	2015	The AnFB-MBR produced consistent high-quality product water when fed by a synthetic groundwater with NO3 (-)-N ranging 25-80 mg/L and operated at hydraulic retention times of 0.5-5.0 h. A nitrate removal rate of up to 4.0 g NO3 (-)-N/Lreactord was attained by the bioreactor, which exceeded any reported removal capacity.	Nitrates	188-195	translocator protein	Homo sapiens	9-12
25343972-2	2015	The AnFB-MBR produced consistent high-quality product water when fed by a synthetic groundwater with NO3 (-)-N ranging 25-80 mg/L and operated at hydraulic retention times of 0.5-5.0 h. A nitrate removal rate of up to 4.0 g NO3 (-)-N/Lreactord was attained by the bioreactor, which exceeded any reported removal capacity.	Nitrates	188-195	NBL1, DAN family BMP antagonist	Homo sapiens	224-227
25422368-5	2015	At higher nitrate doses, however, a partial reversal of this effect occurred; this was accompanied by increased renal erythropoietin expression and stabilization of hypoxia-inducible factors, likely brought about by the relative anemia.	Nitrates	10-17	erythropoietin	Rattus norvegicus	118-132
25422368-7	2015	Suppression of hepatic erythropoietin expression by nitrate may thus act to decrease blood viscosity while matching oxygen supply to demand, whereas renal oxygen sensing could act as a brake, averting a potentially detrimental fall in hematocrit.	Nitrates	52-59	erythropoietin	Rattus norvegicus	23-37
24986777-0	2015	A sensitive and stable amperometric nitrate biosensor employing Arabidopsis thaliana nitrate reductase.	Nitrates	36-43	nitrate reductase 1	Arabidopsis thaliana	85-102
25764461-8	2015	Redundancy analysis showed that dissolved organic carbon, ammonium (NH4 (+)), ferrous iron (Fe(2+)) and nitrate (NO3 (-)) in pore water explained 33.4% of the variation in soil bacterial community composition, implying that urea regimes influenced the relative abundance of some bacterial populations possibly by regulating soil characteristics and then influencing N2O emission.	Nitrates	104-111	NBL1, DAN family BMP antagonist	Homo sapiens	113-116
24986777-4	2015	The GC/NR electrode shows a pronounced cathodic wave for nitrate reduction and the catalytic current increases linearly in the nitrate concentration range of 10-400 microM with a correlation coefficient of 0.989.	Nitrates	127-134	nitrate reductase 1	Arabidopsis thaliana	7-9
24986777-1	2015	Nitrate reductase (NR) from the plant Arabidopsis thaliana has been employed in the development of an amperometric nitrate biosensor that functions at physiological pH.	Nitrates	115-122	nitrate reductase 1	Arabidopsis thaliana	0-17
24986777-1	2015	Nitrate reductase (NR) from the plant Arabidopsis thaliana has been employed in the development of an amperometric nitrate biosensor that functions at physiological pH.	Nitrates	115-122	nitrate reductase 1	Arabidopsis thaliana	19-21
24986777-3	2015	Nitrate is enzymatically reduced to nitrite and the oxidized form of NR is electrochemically reduced by the hydroquinone form of the mediator (AQH2).	Nitrates	0-7	nitrate reductase 1	Arabidopsis thaliana	69-71
24986777-4	2015	The GC/NR electrode shows a pronounced cathodic wave for nitrate reduction and the catalytic current increases linearly in the nitrate concentration range of 10-400 microM with a correlation coefficient of 0.989.	Nitrates	57-64	nitrate reductase 1	Arabidopsis thaliana	7-9
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	56-63	nitrate transport 2	Zea mays	132-136
25554360-1	2015	Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways.	Nitrates	0-7	nitric oxide synthase 2	Homo sapiens	177-198
25554360-1	2015	Nitrate supplementation in the form of beetroot juice has been shown to increase nitric oxide (NO) where nitrate can be reduced to nitrite and, subsequently, to NO through both nitric oxide synthase (NOS)-dependent and -independent pathways.	Nitrates	105-112	nitric oxide synthase 2	Homo sapiens	177-198
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	56-63	ferredoxin--nitrite reductase, chloroplastic	Zea mays	168-185
24944085-0	2015	Anion channel SLAH3 functions in nitrate-dependent alleviation of ammonium toxicity in Arabidopsis.	Nitrates	33-40	SLAC1 homologue 3	Arabidopsis thaliana	14-19
24944085-5	2015	Interestingly, such toxicity was more severe in slah3 mutants and, particularly in wild-type plants, was alleviated by supplementing the media with micromolar levels of nitrate.	Nitrates	169-176	SLAC1 homologue 3	Arabidopsis thaliana	48-53
24944085-6	2015	These data thus provide evidence that SLAH3, a nitrate efflux channel, plays a role in nitrate-dependent alleviation of ammonium toxicity in plants.	Nitrates	47-54	SLAC1 homologue 3	Arabidopsis thaliana	38-43
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	56-63	glutamine synthetase root isozyme 2	Zea mays	187-209
25588735-7	2015	Furthermore, nitrate levels in the ppc1/ppc2 mutant were significantly lower than those in wild-type plants due to the suppression of ammonium assimilation.	Nitrates	13-20	phosphoenolpyruvate carboxylase 1	Arabidopsis thaliana	35-39
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	nitrate transport 2	Zea mays	132-136
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	ferredoxin--nitrite reductase, chloroplastic	Zea mays	168-185
25588735-7	2015	Furthermore, nitrate levels in the ppc1/ppc2 mutant were significantly lower than those in wild-type plants due to the suppression of ammonium assimilation.	Nitrates	13-20	phosphoenolpyruvate carboxylase 2	Arabidopsis thaliana	40-44
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	glutamine synthetase root isozyme 2	Zea mays	187-209
25588735-8	2015	Interestingly, starch and sucrose accumulation could be prevented and nitrate levels could be maintained by supplying the ppc1/ppc2 mutant with exogenous malate and glutamate, suggesting that low nitrogen status resulted in the alteration of carbon metabolism and prompted the accumulation of starch and sucrose in the ppc1/ppc2 mutant.	Nitrates	70-77	phosphoenolpyruvate carboxylase 1	Arabidopsis thaliana	122-126
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	nitrate transport 2	Zea mays	132-136
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	ferredoxin--nitrite reductase, chloroplastic	Zea mays	168-185
25524070-7	2015	On the other hand, the concomitant presence of urea and nitrate enhanced the overexpression of genes involved in nitrate transport (NRT2) and assimilation (nitrate and nitrite reductase, glutamine synthetase 2), and a specific response of 41 transcripts was determined, including glutamine synthetase 1-5, glutamine oxoglutarate aminotransferase, shikimate kinase and arogenate dehydrogenase.	Nitrates	113-120	glutamine synthetase root isozyme 2	Zea mays	187-209
25598207-7	2015	Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2   AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process.	Nitrates	57-64	anoctamin 2	Homo sapiens	10-14
25598207-7	2015	Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2   AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process.	Nitrates	57-64	anoctamin 2	Homo sapiens	154-158
25598207-7	2015	Moreover, AnO2(HL)2(NO3)2 are the most stable species in nitrate-rich acid solutions, while at low nitric acid concentrations, the complexing reaction of AnO2(H2O)5(2+) + 2(HL)2   AnO2(HL2)2 + 2H(+) + 5H2O is probably the dominant reaction in the extraction process.	Nitrates	57-64	anoctamin 2	Homo sapiens	154-158
27682076-8	2015	Sulphate- and nitrate-reducing microbes were particularly responsive to the addition of C-1 compounds and sulphate.	Nitrates	14-21	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	88-91
25723764-0	2015	AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis root tip.	Nitrates	24-31	myb-like transcription factor family protein	Arabidopsis thaliana	8-12
25596127-0	2015	AtTGA4, a bZIP transcription factor, confers drought resistance by enhancing nitrate transport and assimilation in Arabidopsis thaliana.	Nitrates	77-84	TGACG motif-binding factor 4	Arabidopsis thaliana	0-6
25596127-5	2015	Following drought stress there were higher nitrogen and proline contents in transgenic AtTGA4 plants than in wild type controls, and activity of the key enzyme nitrite reductase (NIR) involved in nitrate assimilation processes was also higher.	Nitrates	196-203	nitrite reductase 1	Arabidopsis thaliana	160-177
25596127-6	2015	Expressions of the high-affinity nitrate transporter genes NRT2.1 and NRT2.2 and nitrate reductase genes NIA1 and NIA2 in transgenic plants were all higher than in wild type indicating that higher levels of nitrate transport and assimilation activity contributed to enhanced drought resistance of AtTGA4 transgenic plants.	Nitrates	33-40	nitrate transporter 2:1	Arabidopsis thaliana	59-65
25596127-6	2015	Expressions of the high-affinity nitrate transporter genes NRT2.1 and NRT2.2 and nitrate reductase genes NIA1 and NIA2 in transgenic plants were all higher than in wild type indicating that higher levels of nitrate transport and assimilation activity contributed to enhanced drought resistance of AtTGA4 transgenic plants.	Nitrates	33-40	nitrate transporter 2.2	Arabidopsis thaliana	70-76
25638054-6	2015	The central part of the study area showed elevated nitrate concentration ranging from below detection limit (BDL) to 263.5 mg/l as NO3 (-) and demonstrated high attenuation within the immediate vicinity thereby restricting diffusion of the nitrate to the adjacent parts.	Nitrates	51-58	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
25638054-8	2015	Seventy-seven percent of samples with high nitrate concentration (&gt;45 mg/l as NO3 (-)) showed strong association with high Cl/Br mass ratio (350-900), indicating mixing of sewage and septic tank effluents with groundwater as a primary source for the nitrate in the studied area.	Nitrates	43-50	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
25638054-8	2015	Seventy-seven percent of samples with high nitrate concentration (&gt;45 mg/l as NO3 (-)) showed strong association with high Cl/Br mass ratio (350-900), indicating mixing of sewage and septic tank effluents with groundwater as a primary source for the nitrate in the studied area.	Nitrates	253-260	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
25638054-9	2015	Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
25638054-9	2015	Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
25638054-9	2015	Nitrate level during monsoon (BDL, 229.9 mg/l as NO3 (-)), post-monsoon (BDL, 263.5 mg/l as NO3 (-)), and pre-monsoon (0.5-223.1 mg/l as NO3 (-)) indicated additional contribution of surface leaching to groundwater.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
25416287-0	2015	NODULE INCEPTION antagonistically regulates gene expression with nitrate in Lotus japonicus.	Nitrates	65-72	nin	Lotus japonicus	0-16
25292296-8	2015	The presence of high SO4 (2-)/nitrate (NO3 (-)) concentrations indicated that the burning of coals gives significant contributions to PM10 and PM2.5.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
25056869-4	2015	The bEnd3 cells were exposed to 100 muM Hcy treatment in the presence or absence of 30 muM NaHS (donor of H2S) for 24 h. Hcy-activate NMDA receptor and induced mitochondrial toxicity by increased levels of Ca(2+), NADPH-oxidase-4 (NOX-4) expression, mitochondrial dehydrogenase activity and decreased the level of nitrate, superoxide dismutase (SOD-2) expression, mitochondria membrane potentials, ATP production.	Nitrates	314-321	BEN domain containing 3	Mus musculus	4-9
25592012-0	2015	Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma total homocysteine after folic acid supplementation: a double-blind crossover study.	Nitrates	122-129	nitric oxide synthase 3	Homo sapiens	28-61
25592012-4	2015	The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation.	Nitrates	189-196	nitric oxide synthase 3	Homo sapiens	74-107
25592012-4	2015	The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation.	Nitrates	189-196	nitric oxide synthase 3	Homo sapiens	109-113
25592012-12	2015	A significant difference in the concentration of serum nitrate was detected among individuals with MTHFR C &gt; T677 polymorphisms.	Nitrates	55-62	methylenetetrahydrofolate reductase	Homo sapiens	99-104
25494936-6	2015	First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression.	Nitrates	139-146	uncharacterized protein	Chlamydomonas reinhardtii	21-25
25494936-6	2015	First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression.	Nitrates	139-146	uncharacterized protein	Chlamydomonas reinhardtii	30-34
25494936-6	2015	First, we found that THB1 and THB2 expression is modulated by the nitrogen source and depends on NIT2, a transcription factor required for nitrate assimilation genes expression.	Nitrates	139-146	uncharacterized protein	Chlamydomonas reinhardtii	97-101
25494936-7	2015	Furthermore, THB1 is highly expressed in the presence of NO and is able to convert NO into nitrate in vitro.	Nitrates	91-98	uncharacterized protein	Chlamydomonas reinhardtii	13-17
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	220-227	nin	Lotus japonicus	16-32
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	220-227	nin	Lotus japonicus	34-37
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	220-227	nin	Lotus japonicus	164-167
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	300-307	nin	Lotus japonicus	16-32
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	300-307	nin	Lotus japonicus	34-37
25416287-2	2015	Lotus japonicus NODULE INCEPTION (NIN) is an essential factor that specifically and positively regulates nodulation processes, and has evolved from a member of the NIN-like proteins, of which Arabidopsis homologs target nitrate-responsive elements (NREs), and activate gene expression in response to nitrate.	Nitrates	300-307	nin	Lotus japonicus	164-167
25416287-4	2015	However, nodulation is inhibited in the presence of nitrate, and involvement of NIN in nitrate responses has remained largely unknown.	Nitrates	87-94	nin	Lotus japonicus	80-83
25416287-6	2015	Chromatin immunoprecitiation (ChIP)-PCR analyses showed that NIN targeted NREs in L. japonicus nitrate-inducible gene promoters, including LjNIR1, LjNRT2.1 and LjNRT2.2.	Nitrates	95-102	nin	Lotus japonicus	61-64
25416287-9	2015	NIN ectopic expression interfered with nitrate-dependent activation of these genes.	Nitrates	39-46	nin	Lotus japonicus	0-3
25416287-10	2015	Nitrate treatment followed by NIN activation down-regulated expression of symbiotic NIN target genes.	Nitrates	0-7	nin	Lotus japonicus	84-87
25416287-11	2015	Our results showed that NIN and nitrate antagonistically regulate expression of genes that are activated by nitrate and NIN, respectively.	Nitrates	32-39	nin	Lotus japonicus	120-123
25416287-11	2015	Our results showed that NIN and nitrate antagonistically regulate expression of genes that are activated by nitrate and NIN, respectively.	Nitrates	108-115	nin	Lotus japonicus	24-27
25678741-10	2015	The P(O)OH groups maintain their ability to bind metal ions within the HAP matrix: contacting the modified HAP with 10-4 N nitrate solutions of five transition metal ions gives an affinity sequence of Pb(II) &gt; Cd(II) &gt; Zn(II) &gt; Ni(II) &gt; Cu(II).	Nitrates	123-130	submaxillary gland androgen regulated protein 3B	Homo sapiens	201-207
25064505-1	2015	Metal complexes of the chloride, nitrate and acetate salts of Co(II), Ni(II) Cu(II), Zn(II), Cd(II) or Hg(II) with 2,3-butanedione bis(isonicotinylhydrazone) [BBINH] have been synthesized and structurally characterized.	Nitrates	33-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-68
26451288-3	2015	Recently, we employed a combined histological, metabolomics, and transcriptional and protein analysis approach to establish that nitrate promoted the "browning" of white adipose tissue via the xanthine oxidoreductase catalyzed reductive nitrate-nitrite-nitric oxide pathway.	Nitrates	129-136	xanthine dehydrogenase	Homo sapiens	193-216
26451288-3	2015	Recently, we employed a combined histological, metabolomics, and transcriptional and protein analysis approach to establish that nitrate promoted the "browning" of white adipose tissue via the xanthine oxidoreductase catalyzed reductive nitrate-nitrite-nitric oxide pathway.	Nitrates	237-244	xanthine dehydrogenase	Homo sapiens	193-216
25922551-5	2015	The inflammatory response expressed by PTX3 had a significant relationship with age, heart failure, infarct size, impaired flow in the infarct-related artery, and renal function and positively correlated with neopterin, TNF-alpha, 8-hydroxy-2"-deoxyguanosine, and nitrite/nitrate.	Nitrates	272-279	pentraxin 3	Homo sapiens	39-43
25431333-1	2015	The oxidation of elemental palladium at 100  C in a mixture of fuming nitric acid and a pyridine-SO3 complex leads to the anhydrous nitrate Pd(NO3)2 (monoclinic, P2(1)/n, Z=2, a=469.12(3) pm, b=593.89(3) pm, c=805.72(4) pm, beta=105.989(3) , V=215.79(2) A(3)).	Nitrates	132-139	H3 histone pseudogene 16	Homo sapiens	162-167
25459828-0	2015	Enhanced removal of nitrate using starch/PCL blends as solid carbon source in a constructed wetland.	Nitrates	20-27	PHD finger protein 1	Homo sapiens	41-44
24840342-3	2015	Pretreatment of RBCs with the PKC inhibitor chelerythrine, prior to the addition of phorbol-12-myristate-13-acetate (PMA), an activator of PKC, blocks the appearance of the morphology alterations and the sustained decrease in nitrates and nitrites levels induced by PMA.	Nitrates	226-234	proline rich transmembrane protein 2	Homo sapiens	30-33
25312438-0	2015	Nitrate, nitrite, and nitric oxide find a home in the kidney by offsetting angiotensin II-mediated hypertension.	Nitrates	0-7	angiotensinogen	Homo sapiens	75-89
25312440-3	2015	We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability.	Nitrates	46-53	angiotensinogen	Homo sapiens	145-159
25312440-3	2015	We investigated the hypothesis that inorganic nitrate and nitrite attenuate reactivity of renal microcirculation and blood pressure responses to angiotensin II (ANG II) by modulating nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and NO bioavailability.	Nitrates	46-53	angiotensinogen	Homo sapiens	161-167
25312440-12	2015	Moreover, supplementation with dietary nitrate (10(-2) mol/L) reduced renal NADPH oxidase activity and attenuated ANG II-mediated arteriolar contractions and hypertension (99+-2-146+-2 mm Hg) compared with placebo (100+-3-168+-3 mm Hg).	Nitrates	39-46	angiotensinogen	Homo sapiens	114-120
25512598-3	2015	We found that permeant ions such as nitrate can increase the open probability (Po) of wild-type (WT) CFTR by increasing the opening rate and decreasing the closing rate.	Nitrates	36-43	CF transmembrane conductance regulator	Homo sapiens	101-105
25512598-5	2015	Surprisingly, the effects of nitrate on CFTR gating are remarkably similar to those of VX-770 (N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide), a potent CFTR potentiator used in clinics.	Nitrates	29-36	CF transmembrane conductance regulator	Homo sapiens	40-44
25830329-1	2015	NRT1.1 is a dual-affinity nitrate (NO3(-)) transporter involved in both high- and low-affinity NO3(-) uptake in Arabidopsis plants.	Nitrates	26-33	nitrate transporter 1.1	Arabidopsis thaliana	0-6
25878398-4	2015	Interestingly, the NOS3 -786TT genotype was associated with increased nitrite/nitrate levels only in IEI patients.	Nitrates	78-85	nitric oxide synthase 3	Homo sapiens	19-23
25878398-8	2015	Here, we first demonstrate that NOS3 -786T&gt;C variant affects nitrite/nitrate levels in IEI patients and that screening for NOS2A -2.5 kb (CCTTT) n polymorphism may be useful for differential diagnosis of various IEI.	Nitrates	72-79	nitric oxide synthase 3	Homo sapiens	32-36
25480007-6	2015	The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P.	Nitrates	42-49	hexokinase 1	Arabidopsis thaliana	83-87
25480007-6	2015	The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P.	Nitrates	42-49	hexokinase 1	Arabidopsis thaliana	129-135
25480007-6	2015	The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P.	Nitrates	42-49	hexokinase 1	Arabidopsis thaliana	150-161
25480007-6	2015	The stimulatory effect of Suc and 2-OG on nitrate reduction was less pronounced in hxk1 mutant roots with T-DNA insertion in the AtHXK1 gene encoding hexokinase1 (HXK1) and characterized by reduced hexokinase activity and root level of G6P and F6P.	Nitrates	42-49	hexokinase 1	Arabidopsis thaliana	131-135
26039467-6	2015	Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation.	Nitrates	42-49	CM0216.560.nc	Lotus japonicus	150-154
26039467-0	2015	Shoot HAR1 mediates nitrate inhibition of nodulation in Lotus japonicus.	Nitrates	20-27	CM0216.560.nc	Lotus japonicus	6-10
26252500-0	2015	THB1 regulates nitrate reductase activity and THB1 and THB2 transcription differentially respond to NO and the nitrate/ammonium balance in Chlamydomonas.	Nitrates	15-22	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26039467-2	2015	In a model legume Lotus japonicus, a CLV1-like receptor kinase, HAR1, mediates nitrate inhibition and autoregulation of nodulation.	Nitrates	79-86	CM0216.560.nc	Lotus japonicus	64-68
26039467-5	2015	We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate.	Nitrates	69-76	CM0216.560.nc	Lotus japonicus	43-47
26039467-5	2015	We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate.	Nitrates	69-76	CM0216.560.nc	Lotus japonicus	110-114
26039467-5	2015	We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate.	Nitrates	169-176	CM0216.560.nc	Lotus japonicus	43-47
26039467-5	2015	We performed grafting experiments with the har1 mutant under various nitrate conditions, and found that shoot HAR1 is critical for the inhibition of nodulation at 10 mM nitrate.	Nitrates	169-176	CM0216.560.nc	Lotus japonicus	110-114
26039467-6	2015	Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation.	Nitrates	42-49	CM0216.560.nc	Lotus japonicus	101-105
26039467-6	2015	Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation.	Nitrates	215-222	CM0216.560.nc	Lotus japonicus	101-105
26039467-6	2015	Combined with our recent finding that the nitrate-induced CLE-RS2 glycopeptide binds directly to the HAR1 receptor, this result suggests that CLE-RS2/HAR1 long-distance signaling plays an important role in the both nitrate inhibition and the autoregulation of nodulation.	Nitrates	215-222	CM0216.560.nc	Lotus japonicus	150-154
26252500-12	2015	Thus, when cells are assimilating nitrate and NO appears (i.e. as a consequence of nitrite accumulation), THB1 has a double role: 1) to scavenge NO avoiding its toxic effects and 2) to control the nitrate reduction activity.	Nitrates	197-204	uncharacterized protein	Chlamydomonas reinhardtii	106-110
26252500-5	2015	THB1 and THB2 are regulated by the nitrogen source and respond differentially to NO and the nitrate/ammonium balance.	Nitrates	92-99	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26252500-5	2015	THB1 and THB2 are regulated by the nitrogen source and respond differentially to NO and the nitrate/ammonium balance.	Nitrates	92-99	uncharacterized protein	Chlamydomonas reinhardtii	9-13
26252500-7	2015	THB1 has NOD activity and thus a role in nitrate assimilation.	Nitrates	41-48	uncharacterized protein	Chlamydomonas reinhardtii	0-4
26252500-8	2015	In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation.	Nitrates	32-39	uncharacterized protein	Chlamydomonas reinhardtii	9-13
26252500-8	2015	In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation.	Nitrates	108-115	uncharacterized protein	Chlamydomonas reinhardtii	9-13
26252500-8	2015	In fact, THB1 is upregulated by nitrate and is under the control of NIT2, the major transcription factor in nitrate assimilation.	Nitrates	108-115	uncharacterized protein	Chlamydomonas reinhardtii	68-72
26252500-12	2015	Thus, when cells are assimilating nitrate and NO appears (i.e. as a consequence of nitrite accumulation), THB1 has a double role: 1) to scavenge NO avoiding its toxic effects and 2) to control the nitrate reduction activity.	Nitrates	34-41	uncharacterized protein	Chlamydomonas reinhardtii	106-110
25281097-6	2015	A limit of detection of 24 muM nitrate and a linear concentration range of 200-1400 muM is reported for the microtrench sensor in phosphate buffer and dilute horse serum.	Nitrates	31-38	latexin	Homo sapiens	27-30
25059539-8	2015	Insulin and gliclazide have significantly attenuated, naloxone induced behavioral changes like jumping and rearing frequency, forepaw licking, wet dog shake, sneezing, straightening, circling, OMWS, and various biochemical impairments such as serum glucose, brain MDA, GSH, nitrite/nitrate, and Ca(+2) in morphine-dependent animals (invivo).	Nitrates	282-289	insulin	Canis lupus familiaris	0-7
26247758-5	2015	A maximum specific nitrate removal rate equal to 0.35 g N-NO3- g VSS(-1) d(-1) was reached in R1.	Nitrates	19-26	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
25281097-6	2015	A limit of detection of 24 muM nitrate and a linear concentration range of 200-1400 muM is reported for the microtrench sensor in phosphate buffer and dilute horse serum.	Nitrates	31-38	latexin	Homo sapiens	84-87
25462758-1	2015	Nitrate (NO3-) is commonly dosed in sewer systems to reduce sulfide (H2S) and methane (CH4) produced in anaerobic rising main pipes.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25551441-5	2014	In addition to Norg mineralization, Nx also originated from photochemical nitrate (NO3-) reduction.	Nitrates	74-81	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
25492123-11	2014	CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR.	Nitrates	163-170	DJ64_RS10945	Streptomyces griseorubens	220-237
25514572-0	2014	Negative association between serum parathyroid hormone levels and urinary perchlorate, nitrate, and thiocyanate concentrations in U.S. adults: the National Health and Nutrition Examination Survey 2005-2006.	Nitrates	87-94	parathyroid hormone	Homo sapiens	35-54
25461888-7	2014	NO3-(15)N and NO3-(18)O isotope data indicated the nitrate losses were due to denitrification.	Nitrates	51-58	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
25492123-11	2014	CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR.	Nitrates	163-170	DJ64_RS09700	Streptomyces griseorubens	239-259
25492123-11	2014	CONCLUSION: In this manuscript, we describe the genome features of an isolate of S. griseorubens JSD-1 following with identification and characterization of these nitrate assimilation proteins such as nitrate reductase, nitrite reductase, glutamine synthetase, glutamate synthase and glutamate dehydrogenase accounts for the ability to utilize nitrate as its sole nitrogen source for growth through cellular localization, multiple sequence alignment, putative 3D modeling and quantitative RT-PCR.	Nitrates	163-170	DJ64_RS08780	Streptomyces griseorubens	261-307
25243423-7	2014	Furthermore, HSC70 decreased LPS-induced elevation of circulating tumor necrosis factor alpha and nitrite/nitrate, and tissue expression of inducible nitric oxide synthase, cyclooxygenase 2, and matrix metalloproteinase 9 in the heart and liver.	Nitrates	106-113	heat shock protein family A (Hsp70) member 8	Rattus norvegicus	13-18
24670328-1	2014	Our objective was to investigate whether the presence of Glu298Asp polymorphism in the endothelial NO synthase (eNOS) gene differentially affects the postprandial blood pressure response to dietary nitrate-rich beetroot bread.	Nitrates	198-205	nitric oxide synthase 3	Homo sapiens	112-116
24670328-7	2014	The beneficial diastolic blood pressure reduction was observed only in the T carriers of the Glu298Asp polymorphism in the eNOS gene after consumption of nitrate-rich beetroot bread.	Nitrates	154-161	nitric oxide synthase 3	Homo sapiens	123-127
25452706-3	2014	The mechanism of action of PDE-5 inhibitors results in a potential cumulative drop in blood pressure (BP); thus, these agents are contraindicated in patients receiving nitrates.	Nitrates	168-176	phosphodiesterase 5A	Homo sapiens	27-32
25505423-6	2014	Nitrite/nitrate decreased from 23 (18-27) muM at baseline to 19 (14-24) muM and 18 (14-21) muM in hypoxia and recovery, respectively (p &lt; 0.05).	Nitrates	8-15	latexin	Homo sapiens	42-45
25310505-1	2014	Accurately quantifying nitrate (NO3-) loading from the Mississippi River is important for predicting summer hypoxia in the Gulf of Mexico and targeting nutrient reduction within the basin.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
25239655-2	2014	NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival.	Nitrates	47-54	nitric oxide synthase 3	Homo sapiens	0-4
25239655-2	2014	NOS3 and NOS2 SNPs might modify plasma nitrite/nitrate (NOx) levels, sepsis development, hemodynamics and survival.	Nitrates	47-54	nitric oxide synthase 2	Homo sapiens	9-13
25188017-6	2014	All the CuFe(1-x)Cr(x)S2 (0 &lt;= x &lt;= 0.4) samples show considerably higher photocatalytic activities than P25 toward the reduction of nitrate ions in aqueous solution.	Nitrates	139-146	tubulin polymerization promoting protein	Homo sapiens	111-114
25280017-1	2014	Nitrate (NO3-) is one of the most harmful contaminants in the groundwater, and it causes various health problems.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25349351-12	2014	However, ADG was not affected by nitrate dose (P = 0.54), resulting in a linear improvement in G:F (P = 0.03) as dietary nitrate level increased.	Nitrates	121-128	ADG	Bos taurus	9-12
24149973-10	2014	TPO antibodies were significant predictors of free T4 among non-pregnant women only when the models included urinary perchlorate, nitrate, or thiocyanate.	Nitrates	130-137	thyroid peroxidase	Homo sapiens	0-3
25163536-10	2014	The absence of eNOS leads to enhanced plasma nitrite levels following nitrate administration in vivo, which negatively impacts on platelet function.	Nitrates	70-77	nitric oxide synthase 3	Homo sapiens	15-19
25174989-0	2014	The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.	Nitrates	107-115	aldehyde dehydrogenase 2 family member	Homo sapiens	61-85
25163536-7	2014	Inorganic nitrite drove cGMP-mediated inhibition of human platelet aggregation in vitro and nitrate inhibited platelet function in eNOS(-/-) mice in vivo in a model of thromboembolic radiolabeled platelet aggregation associated with an enhanced plasma nitrite concentration as compared with wild-type mice.	Nitrates	92-99	nitric oxide synthase 3	Homo sapiens	131-135
25174989-0	2014	The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.	Nitrates	107-114	aldehyde dehydrogenase 2 family member	Homo sapiens	61-85
25174989-1	2014	Bioconversion of glyceryl trinitrate (GTN) into nitric oxide (NO) by aldehyde dehydrogenase-2 (ALDH-2) is a crucial mechanism which drives vasodilatory and antiplatelet effect of organic nitrates in vitro and in vivo.	Nitrates	187-195	aldehyde dehydrogenase 2 family member	Homo sapiens	69-93
25174989-1	2014	Bioconversion of glyceryl trinitrate (GTN) into nitric oxide (NO) by aldehyde dehydrogenase-2 (ALDH-2) is a crucial mechanism which drives vasodilatory and antiplatelet effect of organic nitrates in vitro and in vivo.	Nitrates	187-195	aldehyde dehydrogenase 2 family member	Homo sapiens	95-101
25174989-11	2014	In conclusion, oxidative stress subsequent to prolonged use of organic nitrates, which occurs via nitration of ALDH-2, represents a key event in GTN tolerance, an effect counteracted both in vitro and in vivo by novel peroxynitrite decomposition catalyst.	Nitrates	71-79	aldehyde dehydrogenase 2 family member	Homo sapiens	111-117
25229208-0	2014	Secondary organic aerosol formation and organic nitrate yield from NO3 oxidation of biogenic hydrocarbons.	Nitrates	48-55	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
25412694-6	2014	Spatial statistics revealed that ZIP codes with more dairy farms and a higher dairy cow density had higher levels of nitrate contamination.	Nitrates	117-124	fibroblast activation protein alpha	Bos taurus	33-36
25288754-0	2014	Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway.	Nitrates	0-7	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	78-83
25271384-1	2014	Nitrate (NO3(-)) is an abundant component of aerosols, boundary layer surface films, and surface water.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
25288754-4	2014	TCP20, which belongs to an ancient, plant-specific gene family that regulates shoot, flower, and embryo development, was implicated in nitrate signaling by its ability to bind DNA in more than 100 nitrate-regulated genes.	Nitrates	135-142	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	0-5
25288754-5	2014	Analysis of insertion mutants of TCP20 showed that they had normal primary and lateral root growth on homogenous nitrate media but were impaired in preferential lateral root growth (root foraging) on heterogeneous media in split-root plates.	Nitrates	113-120	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	33-38
25288754-6	2014	Inhibition of preferential lateral root growth was still evident in the mutants even when ammonium was uniformly present in the media, indicating that the TCP20 response was to nitrate.	Nitrates	177-184	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	155-160
25288754-8	2014	Further analysis showed that tcp20 mutants lack systemic control of root growth regardless of the local nitrate concentrations.	Nitrates	104-111	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	29-34
25288754-9	2014	These results indicate that TCP20 plays a key role in the systemic signaling pathway that directs nitrate foraging by Arabidopsis roots.	Nitrates	98-105	TEOSINTE BRANCHED 1, cycloidea, PCF (TCP)-domain family protein 20	Arabidopsis thaliana	28-33
24999115-5	2014	In addition, nitrate reduction by nZVI could be catalyzed by Cd(II): while 30% of nitrate was reduced by nZVI within 2 h in the absence of Cd(II), complete nitrate reduction was observed in the presence of 40 mg-Cd/L due to the formation of Cd islands (Cd(0) and CdO) on the nZVI particles.	Nitrates	82-89	cell adhesion associated, oncogene regulated	Homo sapiens	263-266
25310225-11	2014	Acetylcholine also increased the nitrate/nitrite concentration in TRPC3 WT mice, but not in KO mice.	Nitrates	33-40	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	66-71
24999115-5	2014	In addition, nitrate reduction by nZVI could be catalyzed by Cd(II): while 30% of nitrate was reduced by nZVI within 2 h in the absence of Cd(II), complete nitrate reduction was observed in the presence of 40 mg-Cd/L due to the formation of Cd islands (Cd(0) and CdO) on the nZVI particles.	Nitrates	13-20	cell adhesion associated, oncogene regulated	Homo sapiens	263-266
24700131-11	2014	Using ethanol as carbon source, nitrate (N-NO3(-)) removal efficiency of the bioreactor stood around 80 % for a maximum nitrogen loading rate of approximately 6.5 mg N-NO3 (-) L(-1) h(-1).	Nitrates	32-39	NNO3	Homo sapiens	41-46
24700131-11	2014	Using ethanol as carbon source, nitrate (N-NO3(-)) removal efficiency of the bioreactor stood around 80 % for a maximum nitrogen loading rate of approximately 6.5 mg N-NO3 (-) L(-1) h(-1).	Nitrates	32-39	NNO3	Homo sapiens	166-171
24913625-1	2014	NPF (formerly referred to as low-affinity NRT1) and "high-affinity" NRT2 nitrate transporter genes are involved in nitrate uptake by the root, and transport and distribution of nitrate within the plant.	Nitrates	73-80	high-affinity nitrate transporter 2.1	Triticum aestivum	68-72
24913625-1	2014	NPF (formerly referred to as low-affinity NRT1) and "high-affinity" NRT2 nitrate transporter genes are involved in nitrate uptake by the root, and transport and distribution of nitrate within the plant.	Nitrates	115-122	high-affinity nitrate transporter 2.1	Triticum aestivum	68-72
24987011-6	2014	Arabidopsis NLP7 in particular is a major player in the primary nitrate response.	Nitrates	64-71	NIN like protein 7	Arabidopsis thaliana	12-16
25249806-6	2014	CONCLUSION: Early epidemiological studies demonstrated significant associations between high groundwater nitrate levels and elevated methemoglobin levels in infants fed drinking water-diluted formulas.	Nitrates	105-112	hemoglobin subunit gamma 2	Homo sapiens	133-146
25039575-0	2014	Systems approach identifies TGA1 and TGA4 transcription factors as important regulatory components of the nitrate response of Arabidopsis thaliana roots.	Nitrates	106-113	bZIP transcription factor family protein	Arabidopsis thaliana	28-32
25065551-0	2014	The Arabidopsis nitrate transporter NRT2.5 plays a role in nitrate acquisition and remobilization in nitrogen-starved plants.	Nitrates	16-23	nitrate transporter 2:1	Arabidopsis thaliana	36-40
25065551-6	2014	Reduction of NRT2.5 expression resulted in a decrease in high-affinity nitrate uptake without impacting low-affinity uptake.	Nitrates	71-78	nitrate transporter 2:1	Arabidopsis thaliana	13-17
25065551-7	2014	In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants.	Nitrates	39-46	nitrate transporter 2:1	Arabidopsis thaliana	66-70
25065551-7	2014	In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants.	Nitrates	39-46	nitrate transporter 2:1	Arabidopsis thaliana	77-81
25039575-0	2014	Systems approach identifies TGA1 and TGA4 transcription factors as important regulatory components of the nitrate response of Arabidopsis thaliana roots.	Nitrates	106-113	TGACG motif-binding factor 4	Arabidopsis thaliana	37-41
25065551-7	2014	In the background of the high-affinity nitrate transporter mutant nrt2.4, an nrt2.5 mutation reduced nitrate levels in the phloem of N-starved plants further than in the single nrt2.4 mutants.	Nitrates	39-46	nitrate transporter 2:1	Arabidopsis thaliana	77-81
25065551-8	2014	Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization.	Nitrates	199-206	nitrate transporter2.5	Arabidopsis thaliana	72-78
25039575-2	2014	Using an integrative bioinformatics approach we identified TGA1 and TGA4 as putative regulatory factors that mediate nitrate responses in Arabidopsis roots.	Nitrates	117-124	bZIP transcription factor family protein	Arabidopsis thaliana	59-63
25065551-8	2014	Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization.	Nitrates	273-280	nitrate transporter2.5	Arabidopsis thaliana	72-78
25039575-2	2014	Using an integrative bioinformatics approach we identified TGA1 and TGA4 as putative regulatory factors that mediate nitrate responses in Arabidopsis roots.	Nitrates	117-124	TGACG motif-binding factor 4	Arabidopsis thaliana	68-72
25065551-8	2014	Growth analyses of multiple mutants between NRT2.1, NRT2.2, NRT2.4, and NRT2.5 revealed that NRT2.5 is required to support growth of nitrogen-starved adult plants by ensuring the efficient uptake of nitrate collectively with NRT2.1, NRT2.2 and NRT2.4 and by taking part in nitrate loading into the phloem during nitrate remobilization.	Nitrates	273-280	nitrate transporter2.5	Arabidopsis thaliana	72-78
25039575-4	2014	Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs.	Nitrates	127-134	bZIP transcription factor family protein	Arabidopsis thaliana	85-89
25039575-4	2014	Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs.	Nitrates	127-134	TGACG motif-binding factor 4	Arabidopsis thaliana	90-94
25039575-4	2014	Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs.	Nitrates	215-222	bZIP transcription factor family protein	Arabidopsis thaliana	85-89
25039575-4	2014	Global gene expression analysis revealed 97% of the genes with altered expression in tga1 tga4 double mutant plants respond to nitrate treatments, indicating that these transcription factors have a specific role in nitrate responses in Arabidopsis root organs.	Nitrates	215-222	TGACG motif-binding factor 4	Arabidopsis thaliana	90-94
25039575-7	2014	The tga1 tga4 double mutant plants exhibit nitrate-dependent lateral and primary root phenotypes.	Nitrates	43-50	bZIP transcription factor family protein	Arabidopsis thaliana	4-13
25039575-9	2014	Additional root phenotypes of tga1 tga4 double mutants indicate that these transcription factors play an important role in root developmental responses to nitrate.	Nitrates	155-162	bZIP transcription factor family protein	Arabidopsis thaliana	30-39
25039575-10	2014	These results identify TGA1 and TGA4 as important regulatory factors of the nitrate response in Arabidopsis roots.	Nitrates	76-83	bZIP transcription factor family protein	Arabidopsis thaliana	23-27
25106820-2	2014	Here, we show that cadmium inhibits nitrate transporter 1.1 (NRT1.1)-mediated nitrate (NO3 (-)) uptake in Arabidopsis (Arabidopsis thaliana) and impairs NO3 (-) homeostasis in roots.	Nitrates	36-43	nitrate transporter 1.1	Arabidopsis thaliana	61-67
25039575-10	2014	These results identify TGA1 and TGA4 as important regulatory factors of the nitrate response in Arabidopsis roots.	Nitrates	76-83	TGACG motif-binding factor 4	Arabidopsis thaliana	32-36
25326291-1	2014	Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance.	Nitrates	18-25	nitrate transporter 1.1	Arabidopsis thaliana	166-170
25326291-1	2014	Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance.	Nitrates	18-25	nitrate transporter 1.1	Arabidopsis thaliana	177-181
25326291-1	2014	Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance.	Nitrates	83-90	nitrate transporter 1.1	Arabidopsis thaliana	166-170
25326291-1	2014	Stresses decouple nitrate assimilation and photosynthesis through stress-initiated nitrate allocation to roots (SINAR), which is mediated by the nitrate transporters NRT1.8 and NRT1.5 and functions to promote stress tolerance.	Nitrates	83-90	nitrate transporter 1.1	Arabidopsis thaliana	177-181
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	69-86
25173937-0	2014	Nitrate (NO3(-)) and nitrite (NO2(-)) are endocrine disruptors to downregulate expression of tyrosine hydroxylase and motor behavior through conversion to nitric oxide in early development of zebrafish.	Nitrates	0-7	tyrosine hydroxylase	Danio rerio	93-113
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	277-294
25173937-2	2014	Both nitrate and nitrite exposure decreased the expression of tyrosine hydroxylase (TH) in dopaminergic neurons at 48hpf.	Nitrates	5-12	tyrosine hydroxylase	Danio rerio	62-82
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	33-40	estrogen receptor 1	Danio rerio	69-86
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	33-40	estrogen receptor 1	Danio rerio	277-294
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	33-40	estrogen receptor 1	Danio rerio	296-298
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	69-86
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	296-298
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	277-294
25173937-4	2014	When the embryos were exposed to nitrate or nitrite together with an estrogen receptor blocker (ICI 182,780), the decreases in TH expression and motor behavior caused by nitrate or nitrite alone were reversed suggesting the effects of nitrate and nitrite were mediated through estrogen receptor (ER).	Nitrates	170-177	estrogen receptor 1	Danio rerio	296-298
25247426-4	2014	The nitrate removal activity of a biofilm attached to the aspen wood from the bioreactor after 784 days of operation was 0.42 g NO3-N/kg dry weight wood  day.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
25124942-1	2014	A novel discrete open high-nuclearity nest-like silver thiolate cluster complex, [Ag33 S3 (StBu)16 (CF3 COO)9 (NO3 )(CH3 CN)2 ](NO3 ) (1), has been isolated with nitrate and S(2-) anions acting as structure-directing templates.	Nitrates	162-169	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
25124942-1	2014	A novel discrete open high-nuclearity nest-like silver thiolate cluster complex, [Ag33 S3 (StBu)16 (CF3 COO)9 (NO3 )(CH3 CN)2 ](NO3 ) (1), has been isolated with nitrate and S(2-) anions acting as structure-directing templates.	Nitrates	162-169	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
25148521-1	2014	Nitrate (NO3-) is a widespread contaminant of groundwater and surface water across the United States that has deleterious effects to human and ecological health.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
24666321-0	2014	Infrared photodissociation spectroscopy of microhydrated nitrate-nitric acid clusters NO3(-)(HNO3)(m)(H2O)(n).	Nitrates	57-64	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
24666321-5	2014	Addition of at least one more nitric acid molecule or two more water molecules weakens the hydrogen bond network, breaking the symmetry of this arrangement and leading to localization of the proton near one of the nitrate cores, effectively forming HNO3 hydrogen-bonded to NO3(-).	Nitrates	214-221	NBL1, DAN family BMP antagonist	Homo sapiens	250-253
25039985-0	2014	The intrinsically disordered structural platform of the plant defence hub protein RPM1-interacting protein 4 provides insights into its mode of action in the host-pathogen interface and evolution of the nitrate-induced domain protein family.	Nitrates	203-210	RPM1 interacting protein 4	Arabidopsis thaliana	82-108
25053401-8	2014	We also investigated an animal model of CKD (Col4a3(-/-) mice) that displays highly elevated serum FGF23 levels and found they had impaired endothelium-dependent vascular relaxation and reduced nitrate production compared with age-matched wild types.	Nitrates	194-201	collagen, type IV, alpha 3	Mus musculus	45-51
24718849-6	2014	Before admission, a higher percentage of COPD patients had experienced infections (25.0 vs. 14.0 %, p &lt; 0.001), and were more likely to receive diuretics (p = 0.006), ACE inhibitors (p = 0.042), nitrates (p = 0.003), and digoxin (p = 0.034).	Nitrates	198-206	COPD	Homo sapiens	41-45
25039985-3	2014	AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family.	Nitrates	20-27	RPM1 interacting protein 4	Arabidopsis thaliana	0-6
25039985-3	2014	AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family.	Nitrates	20-27	RPM1-interacting protein 4 (RIN4) family protein	Arabidopsis thaliana	37-40
25039985-3	2014	AtRIN4 contains two nitrate-induced (NOI) domains and is a member of the NOI family.	Nitrates	20-27	RPM1-interacting protein 4 (RIN4) family protein	Arabidopsis thaliana	73-76
23894175-6	2014	Nitrate concentrations averaged 13.6 +- 3.7 muM and 12.7 +- 4.9 muM, respectively.	Nitrates	0-7	latexin	Homo sapiens	44-47
24914193-7	2014	The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg.	Nitrates	135-142	endothelin 1	Rattus norvegicus	4-8
24914193-7	2014	The ET-1+endothelin receptor type-A antagonist BQ-123 and the ETBR agonists sarafotoxin 6c and IRL-1620 caused less vasorelaxation and nitrate/nitrite production in RUPP than in Norm-Preg.	Nitrates	135-142	endothelin receptor type B	Rattus norvegicus	62-66
23894175-6	2014	Nitrate concentrations averaged 13.6 +- 3.7 muM and 12.7 +- 4.9 muM, respectively.	Nitrates	0-7	latexin	Homo sapiens	64-67
24548141-0	2014	Chlamydomonas NZF1, a tandem-repeated zinc finger factor involved in nitrate signalling by controlling the regulatory gene NIT2.	Nitrates	69-76	uncharacterized protein	Chlamydomonas reinhardtii	123-127
25193828-6	2014	The areas showing predicted nitrate concentrations in the leachate above the EU groundwater quality standard of 50mg NO3(-)/L have been identified as priority areas for implementing nitrogen reduction measures.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	117-120
24548141-1	2014	The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth.	Nitrates	64-71	uncharacterized protein	Chlamydomonas reinhardtii	30-34
24548141-1	2014	The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth.	Nitrates	64-71	uncharacterized protein	Chlamydomonas reinhardtii	92-96
24548141-1	2014	The Chlamydomonas reinhardtii NIT2 gene plays a central role in nitrate assimilation, thus, nit2 mutants are not able to sense or to use nitrate for growth.	Nitrates	137-144	uncharacterized protein	Chlamydomonas reinhardtii	30-34
24548141-4	2014	However, intracellular nitrate is required to activate NIT2 for subsequent expression of NIA1 and other nitrate assimilation genes.	Nitrates	23-30	uncharacterized protein	Chlamydomonas reinhardtii	55-59
24548141-4	2014	However, intracellular nitrate is required to activate NIT2 for subsequent expression of NIA1 and other nitrate assimilation genes.	Nitrates	104-111	uncharacterized protein	Chlamydomonas reinhardtii	55-59
24858657-1	2014	BACKGROUND: In this substudy of the effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes, we report the development of a novel nitrate depleted beetroot juice for use clinical trials and determine if dietary nitrate supplementation improved cognitive function in patients with type 2 diabetes mellitus.	Nitrates	184-191	insulin	Homo sapiens	107-114
24859195-4	2014	The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2.	Nitrates	4-11	endogenous retrovirus group W member 5	Homo sapiens	217-220
24859195-4	2014	The nitrate-reducing bacteria (NRB) Dechloromonas exhibited the greatest corrosion inhibition by inducing the redox cycling of iron to enhance the precipitation of iron oxides and formation of Fe3O4 in the AR with UV/Cl2, while the rhizobia Bradyrhizobium and Rhizobium, and the NRB Sphingomonas, Brucella producing siderophores had weaker corrosion-inhibition effect by capturing iron in the AR with Cl2.	Nitrates	4-11	endogenous retrovirus group W member 5	Homo sapiens	401-404
24858657-1	2014	BACKGROUND: In this substudy of the effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes, we report the development of a novel nitrate depleted beetroot juice for use clinical trials and determine if dietary nitrate supplementation improved cognitive function in patients with type 2 diabetes mellitus.	Nitrates	184-191	insulin	Homo sapiens	107-114
25522608-9	2014	The contents of nitrate nitrogen in the root and leaves reached the highest at the NH4(+) -N/NO3(-) -N ratio of 50:50.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
25140876-1	2014	The ANR1 MADS-box gene in Arabidopsis is a key gene involved in regulating lateral root development in response to the external nitrate supply.	Nitrates	128-135	AGAMOUS-like 44	Arabidopsis thaliana	4-8
25158065-5	2014	Therefore, we hypothesized that nitrate tolerance induced by persistent GTN treatment results from NOS3 dysfunction and vascular toxicity.	Nitrates	32-39	nitric oxide synthase 3, endothelial cell	Mus musculus	99-103
24858219-1	2014	Water pollution in the form of nitrate nitrogen (NO3(-)-N) contamination is a major concern in most agricultural areas in the world.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
24858219-6	2014	Overall, the highest nitrate levels were observed in surface water in May and in groundwater in June, indicating that fertilizer application, precipitation, and irrigation strongly influence the NO3(-)-N concentrations.	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	195-198
25101106-1	2014	The dynamics of nitrate (NO(-) 3), a major nitrogen (N) source for natural plants, has been studied mostly through experimental N addition, enzymatic assay, isotope labeling, and genetic expression.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	25-32
25127459-4	2014	Still, denitrification alone can often account for only half of the substantial nitrate (NO3-) consumption.	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
25127459-8	2014	Intriguingly, we also observed that between 20 and 40% of 15NO3- added to the incubations entered an intracellular pool of NO3- and was subsequently respired when nitrate became limiting.	Nitrates	163-170	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
25001619-4	2014	Under optimal conditions, the limits of detection and quantification for nitrite are 1.0 and 7.8 muM, respectively, while the corresponding values for nitrate are 19 and 48 muM, respectively.	Nitrates	151-158	latexin	Homo sapiens	173-176
24791832-1	2014	Although interest in biomarkers in the nitrate-nitrite-NO pathway has recently increased, associations between nitrite (NO2(-)) and nitrate (NO3(-)), and asthma, allergic sensitisation and rhinitis remain unclear.	Nitrates	132-139	NBL1, DAN family BMP antagonist	Homo sapiens	141-144
24829498-7	2014	NOS1 protein expression, however, significantly increased with HS only in SHR, and this corresponded to an increase in urinary nitrate/nitrite excretion.	Nitrates	127-134	nitric oxide synthase 1	Rattus norvegicus	0-4
25071800-2	2014	A central reaction in the cycle involves the reduction of nitrate (NO(-) 3) to nitrite (NO(-) 2) catalyzed by nitrate reductase (NR).	Nitrates	58-65	nitrate reductase 1	Arabidopsis thaliana	110-127
24854623-4	2014	The effect of nitrate concentration on the extraction of lanthanides with 1-MIM in ILs was analysed.	Nitrates	14-21	MTSS I-BAR domain containing 1	Homo sapiens	76-79
25373851-12	2014	We found higher PTX3 concentrations in patients with Canadian Cardiovascular Society (CCS) functional class 3 (compared to CCS functional class 2) and in patients taking nitrates.	Nitrates	170-178	pentraxin 3	Homo sapiens	16-20
25005229-2	2014	The Arabidopsis thaliana anion/proton exchanger AtCLCa is involved in vacuolar accumulation of nitrate.	Nitrates	95-102	chloride channel A	Arabidopsis thaliana	48-54
24875878-4	2014	In a second step, a simple linear model is proposed for nitrate-DOC relationship (alpha NO3+beta DOC=1) and a validation is proposed for more than 150 samples of different Brittany rivers and lakes.	Nitrates	56-63	cyclin dependent kinase 2 associated protein 1	Homo sapiens	97-102
25373851-15	2014	CONCLUSIONS: PTX3 is a marker of clinically more advanced CAD (CCS2 vs CCS3; nitrates vs no nitrates).	Nitrates	77-85	pentraxin 3	Homo sapiens	13-17
25373851-15	2014	CONCLUSIONS: PTX3 is a marker of clinically more advanced CAD (CCS2 vs CCS3; nitrates vs no nitrates).	Nitrates	92-100	pentraxin 3	Homo sapiens	13-17
24742815-7	2014	Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells.	Nitrates	164-171	sphingomyelin phosphodiesterase 2	Homo sapiens	22-27
24742815-7	2014	Inhibition of neutral SMase (N-SMase) activity via GW 4869 treatment caused a significant reduction in nuclear translocation of NF-kappaB, NOS2 expression, nitrite/nitrate levels, nitrotyrosine formation, and apoptosis in ER-stressed RPE cells.	Nitrates	164-171	sphingomyelin phosphodiesterase 2	Homo sapiens	29-36
24430487-5	2014	As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids.	Nitrates	32-39	NSF attachment protein alpha	Homo sapiens	3-7
24430487-5	2014	As NapA has a high affinity for nitrate compared with the membrane-bound enzyme, its occurrence in vent Epsilonproteobacteria may represent an adaptation of these organisms to the low nitrate concentrations typically found in vent fluids.	Nitrates	184-191	NSF attachment protein alpha	Homo sapiens	3-7
24799562-0	2014	Disruption of the mitochondrial alternative oxidase (AOX) and uncoupling protein (UCP) alters rates of foliar nitrate and carbon assimilation in Arabidopsis thaliana.	Nitrates	110-117	alternative oxidase 2	Arabidopsis thaliana	32-51
24799562-0	2014	Disruption of the mitochondrial alternative oxidase (AOX) and uncoupling protein (UCP) alters rates of foliar nitrate and carbon assimilation in Arabidopsis thaliana.	Nitrates	110-117	alternative oxidase 2	Arabidopsis thaliana	53-56
24904028-8	2014	Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids.	Nitrates	83-90	Integral membrane HPP family protein	Arabidopsis thaliana	17-26
24904028-8	2014	Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids.	Nitrates	83-90	Integral membrane HPP family protein	Arabidopsis thaliana	43-52
24904028-8	2014	Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids.	Nitrates	178-185	Integral membrane HPP family protein	Arabidopsis thaliana	17-26
24904028-8	2014	Transcription of AT5G62720 (AtNITR2;1) and AT3G47980 (AtNITR2;2) was stimulated by nitrate under the control of the NIN-like proteins, suggesting that the HPP proteins represent nitrate-inducible components of the nitrite transport system of plastids.	Nitrates	178-185	Integral membrane HPP family protein	Arabidopsis thaliana	43-52
25158487-2	2014	The results showed that there were different forms of N transport by subsurface flow under different rainfall events, where in dissolved nitrogen (DN) accounted for about 53.74% - 99.21%, and nitrate (NO3(-) -N) accounted for about 35.70% - 93.65% of DN, and especially under the moderate rainfall, NO3(-) -N could reach 84.09% - 93.65% of DN.	Nitrates	192-199	NBL1, DAN family BMP antagonist	Homo sapiens	201-204
24748593-2	2014	The present study was designed to evaluate the relationship between exercise training and NOS3 polymorphisms at -786T&gt;C, 894G&gt;T, and intron 4b/a on blood pressure (BP) using 24-h ambulatory BP monitoring (ABPM), nitrate/nitrite levels (NOx), and redox state.	Nitrates	218-225	nitric oxide synthase 3	Homo sapiens	90-94
24662464-0	2014	Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition.	Nitrates	0-7	cytochrome c, somatic	Equus caballus	22-34
24938289-9	2014	Changing the polar character of a single amino acid side chain (Ser-228) to a nonpolar residue turned the nitrate-selective SLAH2 into a chloride/nitrate-permeable anion channel.	Nitrates	146-153	SLAC1 homologue 2	Arabidopsis thaliana	124-129
24663342-6	2014	Treatment of mEL5 with nitrate or nitrite caused meristematic cell death accompanied by browning.	Nitrates	23-30	epilepsy 5	Mus musculus	13-17
25191617-7	2014	Betalains, polyphenols and dietary nitrate found in the beetroot juice may each contribute to the observed differences in the postprandial insulin concentration.	Nitrates	35-42	insulin	Homo sapiens	139-146
24938289-0	2014	A Single-Pore Residue Renders the Arabidopsis Root Anion Channel SLAH2 Highly Nitrate Selective.	Nitrates	78-85	SLAC1 homologue 2	Arabidopsis thaliana	65-70
24938289-3	2014	The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions.	Nitrates	143-150	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	59-78
24938289-3	2014	The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions.	Nitrates	143-150	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	80-85
24938289-3	2014	The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions.	Nitrates	143-150	SLAC1 homologue 3	Arabidopsis thaliana	103-120
24938289-3	2014	The Arabidopsis thaliana shoot expresses the anion channel SLOW ANION CHANNEL1 (SLAC1) and its homolog SLAC1 HOMOLOGOUS3 (SLAH3), which prefer nitrate as substrate but cannot exclude chloride ions.	Nitrates	143-150	SLAC1 homologue 3	Arabidopsis thaliana	122-127
24938289-4	2014	By contrast, we identified SLAH2 as a nitrate-specific channel that is impermeable for chloride.	Nitrates	38-45	SLAC1 homologue 2	Arabidopsis thaliana	27-32
24938289-5	2014	To understand the molecular basis for nitrate selection in the SLAH2 channel, SLAC1 and SLAH2 were modeled to the structure of HiTehA, a distantly related bacterial member.	Nitrates	38-45	SLAC1 homologue 2	Arabidopsis thaliana	63-68
24938289-5	2014	To understand the molecular basis for nitrate selection in the SLAH2 channel, SLAC1 and SLAH2 were modeled to the structure of HiTehA, a distantly related bacterial member.	Nitrates	38-45	SLAC1 homologue 2	Arabidopsis thaliana	88-93
24938289-6	2014	Structure-guided site-directed mutations converted SLAC1 into a SLAH2-like nitrate-specific anion channel and vice versa.	Nitrates	75-82	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	51-56
24938289-6	2014	Structure-guided site-directed mutations converted SLAC1 into a SLAH2-like nitrate-specific anion channel and vice versa.	Nitrates	75-82	SLAC1 homologue 2	Arabidopsis thaliana	64-69
24938289-9	2014	Changing the polar character of a single amino acid side chain (Ser-228) to a nonpolar residue turned the nitrate-selective SLAH2 into a chloride/nitrate-permeable anion channel.	Nitrates	106-113	SLAC1 homologue 2	Arabidopsis thaliana	124-129
24512212-7	2014	Inhibition of iNOS via administration of 1400W ameliorated renal injury and decreased tissue lipid peroxidation (malondialdehyde), superoxide dismutase, glutathione peroxidase and nitrite/nitrate levels (NOx).	Nitrates	188-195	nitric oxide synthase 2	Rattus norvegicus	14-18
24594525-2	2014	In vitro tests revealed that compounds 3 and 5, which bear a nitrate moiety in the molecule, showed a potent inhibition activity towards AChE and compound 3 showed a good Abeta42 aggregation inhibitory activity.	Nitrates	61-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-141
24555687-1	2014	Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of aldehyde dehydrogenase 2 (ALDH2), and decreased GTN-induced cGMP accumulation and vasodilation.	Nitrates	13-21	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	103-127
24555687-1	2014	Tolerance to nitrates such as nitroglycerin (GTN) is associated with oxidative stress, inactivation of aldehyde dehydrogenase 2 (ALDH2), and decreased GTN-induced cGMP accumulation and vasodilation.	Nitrates	13-21	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	129-134
24633562-7	2014	Tap water and bottled water were also analyzed by the column, and nitrate was detected as 20.1 and 13.8 mg L(-1), respectively.	Nitrates	66-73	nuclear RNA export factor 1	Homo sapiens	0-3
24356583-1	2014	The APEX software predicts the photochemical transformation kinetics of xenobiotics in surface waters as a function of: photoreactivity parameters (direct photolysis quantum yield and second-order reaction rate constants with transient species, namely  OH, CO3(-) , (1)O2 and the triplet states of chromophoric dissolved organic matter, (3)CDOM*), water chemistry (nitrate, nitrite, bicarbonate, carbonate, bromide and dissolved organic carbon, DOC), and water depth (more specifically, the optical path length of sunlight in water).	Nitrates	365-372	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	4-8
24617811-1	2014	This study demonstrates that the production of reactive oxidizing species (e.g., hydroxyl radical ( OH)) during the photolysis of nitrite (NO2(-)) or nitrate (NO3(-)) leads to the oxidative conversion of arsenite (As(III)) to arsenate (As(V)).	Nitrates	150-157	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
24617811-3	2014	Nitrate-mediated photooxidation of As(III) revealed an initial lag phase during which NO3(-) is converted into NO2(-).	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	86-89
24463937-7	2014	Whereas, Ang-(1-9) increased endothelial nitric oxide synthase mRNA levels in aorta as well as plasma nitrate levels.	Nitrates	102-109	angiogenin	Rattus norvegicus	9-17
24553295-7	2014	However, hydrocarbon removal in FTF 5 under anaerobic conditions with nitrate and sulphate electron acceptors was limited suggesting that aerobic conditions were crucial for hydrocarbon removal.	Nitrates	70-77	nuclear receptor subfamily 5 group A member 2	Homo sapiens	32-35
24623305-1	2014	To monitor nitrate and peptide transport activity in vivo, we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4, and 5 into fluorescence activity sensors (NiTrac1, PepTrac).	Nitrates	90-97	cell adhesion molecule L1 like	Homo sapiens	110-114
24601645-4	2014	Describing uranyl and nitrate ions with integer charges (+2 and -1, respectively) is shown to exaggerate the hydrophilicity and surface activity of the UO2(NO3)2(TBP)2 complex.	Nitrates	22-29	TATA-box binding protein	Homo sapiens	162-165
24512498-7	2014	The mixing and gradient formation units were incorporated into a device for analysis of nitrate in tap water with standard addition as a single run and multiple depth detection cells to provide an extended linear range.	Nitrates	88-95	nuclear RNA export factor 1	Homo sapiens	99-102
24623305-1	2014	To monitor nitrate and peptide transport activity in vivo, we converted the dual-affinity nitrate transceptor CHL1/NRT1.1/NPF6.3 and four related oligopeptide transporters PTR1, 2, 4, and 5 into fluorescence activity sensors (NiTrac1, PepTrac).	Nitrates	90-97	immunoglobulin superfamily member 9	Homo sapiens	115-119
24142995-5	2014	Elevated pre-transplant levels of serum nitrates (&gt;26.5 muM) predicted steroid-refractory graft-versus-host disease (P=0.026) and non-relapse mortality (P=0.028), particularly in combination with high pre-transplant angiopoietin-2 levels (P=0.0007 and P=0.021, respectively).	Nitrates	40-48	angiopoietin 2	Homo sapiens	219-233
24572362-2	2014	Previous studies have identified Arabidopsis NRT1.1 as a dual-affinity nitrate transporter that can take up nitrate over a wide range of concentrations.	Nitrates	71-78	nitrate transporter 1.1	Arabidopsis thaliana	45-49
24572362-7	2014	Together with analyses of the substrate transport tunnel, our results establish a phosphorylation-controlled dimerization switch that allows NRT1.1 to uptake nitrate with two distinct affinity modes.	Nitrates	158-165	nitrate transporter 1.1	Arabidopsis thaliana	141-145
24572366-0	2014	Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1.	Nitrates	19-26	nitrate transporter 1.1	Arabidopsis thaliana	67-73
24572366-3	2014	In response to falling nitrate levels, NRT1.1 is phosphorylated on an intracellular threonine that switches the transporter from a low-affinity to high-affinity state.	Nitrates	23-30	nitrate transporter 1.1	Arabidopsis thaliana	39-43
24572366-4	2014	Here we present both the apo and nitrate-bound crystal structures of Arabidopsis thaliana NRT1.1, which together with in vitro binding and transport data identify a key role for His 356 in nitrate binding.	Nitrates	33-40	nitrate transporter 1.1	Arabidopsis thaliana	90-96
24572366-4	2014	Here we present both the apo and nitrate-bound crystal structures of Arabidopsis thaliana NRT1.1, which together with in vitro binding and transport data identify a key role for His 356 in nitrate binding.	Nitrates	189-196	nitrate transporter 1.1	Arabidopsis thaliana	90-96
24337990-9	2014	Denuder-fitted PM1 sampler can serve as a useful sampling tool in estimating the true values for nitrate, ammonium, potassium, sodium and WSOC present in the ambient PM.	Nitrates	97-104	transmembrane protein 11	Homo sapiens	15-18
24532452-1	2014	NRT2.7 is a seed-specific high-affinity nitrate transporter controlling nitrate content in Arabidopsis mature seeds.	Nitrates	40-47	nitrate transporter 2:1	Arabidopsis thaliana	0-4
24280052-4	2014	The initial nitrate concentration was 142mgL(-1), and the concentrations decreased by 80%, 84%, and 79% in System A, B, and C, respectively.	Nitrates	12-19	LLGL scribble cell polarity complex component 1	Homo sapiens	41-47
24531490-0	2014	Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state.	Nitrates	0-7	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	30-61
24363367-5	2014	We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter.	Nitrates	66-73	Ssu1p	Saccharomyces cerevisiae S288C	39-43
24194418-5	2014	The co-existence of two inorganic nitrogen sources (ammonia and nitrate) had certain impact on simazine dissipation by the strain SD1.	Nitrates	64-71	CUP2Q35	Homo sapiens	130-133
24363367-5	2014	We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter.	Nitrates	66-73	SCF ubiquitin ligase complex subunit GRR1	Saccharomyces cerevisiae S288C	48-52
24363367-5	2014	We identified the sulfite transporters Ssu1 and Ssu2 as effective nitrate exporters, Ssu2 being quantitatively more important, and we characterize the Nar1 protein as a nitrate/nitrite exporter.	Nitrates	169-176	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	151-155
24363367-8	2014	We also have shown that the well-known Saccharomyces cerevisiae sulfite efflux permease Ssu1 is also able to excrete nitrite and nitrate.	Nitrates	129-136	Ssu1p	Saccharomyces cerevisiae S288C	88-92
24097244-4	2014	In addition, research has shown that there is crosstalk between the CBL-CIPK pathway and the low-K+ response pathway, the ABA signaling pathway, the nitrate sensing and signaling pathway, and others.	Nitrates	149-156	Cbl proto-oncogene	Homo sapiens	68-71
23731510-3	2014	A study was carried out to quantify the effects of the ND in the EU-27 on the leaching and runoff of nitrate (NO3(-)) to groundwater and surface waters, and on the emissions of ammonia (NH3), nitrous oxide (N2O), nitrogen oxides (NO(x)) and dinitrogen (N2) to the atmosphere.	Nitrates	101-108	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
24388610-7	2014	Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development.	Nitrates	107-114	CAPRICE-like MYB3	Arabidopsis thaliana	12-16
24388610-7	2014	Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development.	Nitrates	107-114	CAPRICE-like MYB3	Arabidopsis thaliana	92-96
24388610-7	2014	Knockout of ETC3/CPL3 did not influence anthocyanin accumulation, but the results establish ETC3/CPL3 as a nitrate regulated gene and a putative candidate for being involved in nitrate status signaling and root development.	Nitrates	107-114	CAPRICE-like MYB3	Arabidopsis thaliana	97-101
24441717-5	2014	Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p&lt;0.05).	Nitrates	7-14	nitric oxide synthase 2	Rattus norvegicus	73-104
24441717-5	2014	Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p&lt;0.05).	Nitrates	7-14	nitric oxide synthase 2	Rattus norvegicus	106-110
24346018-2	2014	Subsets of circulating blood cells, including red blood cells (RBCs), carry a NOS3 and contribute to blood pressure regulation and RBC nitrite/nitrate formation.	Nitrates	143-150	nitric oxide synthase 3, endothelial cell	Mus musculus	78-82
25020005-1	2014	Heavy carbon steel corrosion developed during nitrate mitigation of a flow rig connected to a water injection pipeline flowing anaerobe saline aquifer water.	Nitrates	46-53	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	75-78
25114912-10	2014	Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions.	Nitrates	8-15	macrophage migration inhibitory factor	Homo sapiens	44-47
25114912-12	2014	Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function.	Nitrates	48-55	macrophage migration inhibitory factor	Homo sapiens	102-105
24183883-8	2014	In multiple regression analysis homocysteine, sVCAM-1, and urinary nitrate/nitrite remained independent determinants of resistin levels (R(2) adjusted=0.347, p=0.000).	Nitrates	67-74	resistin	Homo sapiens	120-128
25020005-4	2014	Nitrate amendment caused an 18-fold smaller SRB population, but up to 44 times higher sulfate reduction rates.	Nitrates	0-7	chaperonin containing TCP1 subunit 4	Homo sapiens	44-47
25410225-10	2014	The use of PDE-5 inhibitors in the presence of oral nitrates is strictly contraindicated in diabetic men, as in nondiabetic subjects.	Nitrates	52-60	phosphodiesterase 5A	Homo sapiens	11-16
24923291-2	2014	The new compound CLC-3000 is an aminoethyl nitrate (AEN) derivative of pioglitazone, a thiazolidinedione antidiabetic agent combining the peroxisome proliferator-activated receptor gamma agonist activity of pioglitazone with the NO-donating activity of the nitrate moiety.	Nitrates	43-50	cardiotrophin-like cytokine factor 1	Rattus norvegicus	17-20
23775870-9	2014	When considering NOC precursors, risk was consistently higher among subjects with concurrent high intake of nitrate and high intake of the different meats (sources of amines and nitrosamines).	Nitrates	108-115	nocturnin	Homo sapiens	17-20
24642889-10	2014	CONCLUSION: The present study demonstrated that nicorandil induces COX-2 via GATA-4 induction in the heart through both KATP channel activation and its nitrate-like properties.	Nitrates	152-159	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	67-72
24642889-10	2014	CONCLUSION: The present study demonstrated that nicorandil induces COX-2 via GATA-4 induction in the heart through both KATP channel activation and its nitrate-like properties.	Nitrates	152-159	GATA binding protein 4	Rattus norvegicus	77-83
24923291-4	2014	RESULTS: In vitro, CLC-3000 displayed more potent vasodilation than pioglitazone alone or classical nitrates.	Nitrates	100-108	cardiotrophin-like cytokine factor 1	Rattus norvegicus	19-22
24923291-9	2014	CONCLUSION: In summary, the results of these studies demonstrate that CLC-3000 contains a vasodilative and antithrombotic activity that is not evident with pioglitazone alone, and that 7 days of exposure in vivo showed no typical signs of nitrate tolerance, endothelial dysfunction or other safety concerns in Wistar rats.	Nitrates	239-246	cardiotrophin-like cytokine factor 1	Rattus norvegicus	70-73
24259683-4	2014	Expression in Xenopus laevis oocytes and two-electrode voltage clamp measurements showed that VvNPF3.2 is a low-affinity transporter for both nitrate and nitrite and displays characteristics of NPF members from other plants.	Nitrates	142-149	protein NRT1/ PTR FAMILY 3.1	Vitis vinifera	94-102
23731054-0	2014	Auxin-mediated nitrate signalling by NRT1.1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability.	Nitrates	15-22	nitrate transporter 1.1	Arabidopsis thaliana	37-41
23731054-0	2014	Auxin-mediated nitrate signalling by NRT1.1 participates in the adaptive response of Arabidopsis root architecture to the spatial heterogeneity of nitrate availability.	Nitrates	147-154	nitrate transporter 1.1	Arabidopsis thaliana	37-41
23731054-4	2014	Using a split-root system, we explored the hypothesis that preferential lateral root growth in the nitrate-rich side involves the NRT1.1-dependent repression of lateral root growth in the low nitrate side.	Nitrates	99-106	nitrate transporter 1.1	Arabidopsis thaliana	130-134
23731054-5	2014	Data show that NRT1.1 acts locally to modulate both auxin levels and meristematic activity in response to the low nitrate concentration directly experienced by lateral roots leading to a repression of their growth.	Nitrates	114-121	nitrate transporter 1.1	Arabidopsis thaliana	15-19
23731054-6	2014	A stimulatory role of NRT1.1 in the high nitrate side, which does not rely on changes in auxin levels, is also observed.	Nitrates	41-48	nitrate transporter 1.1	Arabidopsis thaliana	22-28
23731054-7	2014	Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism.	Nitrates	82-89	nitrate transporter 1.1	Arabidopsis thaliana	34-40
23731054-7	2014	Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism.	Nitrates	153-160	nitrate transporter 1.1	Arabidopsis thaliana	34-40
23731054-7	2014	Altogether, our data suggest that NRT1.1 allows preferential root colonization of nitrate-rich patches by both preventing root growth in response to low nitrate, through modulation of auxin traffic, and stimulating root growth in response to high nitrate, through a yet uncharacterized mechanism.	Nitrates	153-160	nitrate transporter 1.1	Arabidopsis thaliana	34-40
23731054-8	2014	In addition, transcriptional regulation of NRT1.1 affects both mechanisms allowing plants to modulate the effect of nitrate on root branching.	Nitrates	116-123	nitrate transporter 1.1	Arabidopsis thaliana	43-47
24272701-6	2014	Nitrate-mediated NRT2.1 expression is not influenced by gin2-1, showing that Glc does not influence NRT2.1 expression through nitrate-mediated mechanisms.	Nitrates	0-7	nitrate transporter 2:1	Arabidopsis thaliana	17-23
24272701-7	2014	We also show that Glc stimulates NRT2.1 protein levels and transport activity independently of its HEXOKINASE1-mediated stimulation of NRT2.1 expression, demonstrating another possible posttranscriptional mechanism influencing nitrate uptake.	Nitrates	227-234	nitrate transporter 2:1	Arabidopsis thaliana	33-39
24259683-5	2014	We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity.	Nitrates	98-105	Major facilitator superfamily protein	Arabidopsis thaliana	41-49
24259683-5	2014	We also cloned the Arabidopsis ortholog, AtNPF3.1, and showed that AtNPF3.1 similarly transported nitrate and nitrite with low affinity.	Nitrates	98-105	Major facilitator superfamily protein	Arabidopsis thaliana	67-75
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	0-7	auxin signaling F-box 3	Arabidopsis thaliana	22-26
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	45-52	auxin signaling F-box 3	Arabidopsis thaliana	70-74
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	0-7	NAC domain containing protein 80	Arabidopsis thaliana	31-35
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	45-52	NAC domain containing protein 80	Arabidopsis thaliana	110-114
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	181-187
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	151-158	auxin signaling F-box 3	Arabidopsis thaliana	70-74
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	151-158	NAC domain containing protein 80	Arabidopsis thaliana	110-114
24642706-3	2014	We found that gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor depends on the nitrate transport function of NRT1.1.	Nitrates	151-158	nitrate transporter 1.1	Arabidopsis thaliana	181-187
24642706-4	2014	This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches.	Nitrates	191-198	nitrate transporter 1.1	Arabidopsis thaliana	33-39
24642706-4	2014	This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches.	Nitrates	191-198	auxin signaling F-box 3	Arabidopsis thaliana	43-47
24642706-4	2014	This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches.	Nitrates	191-198	NAC domain containing protein 80	Arabidopsis thaliana	52-56
24642706-4	2014	This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches.	Nitrates	191-198	nitrate reductase 1	Arabidopsis thaliana	134-138
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	84-88
24642706-4	2014	This gene regulatory function of NRT1.1 on AFB3 and NAC4 differs from the previously described signaling function controlling NRT2.1, NIA1 and NIA2 transcript levels and root colonization of nitrate-rich patches.	Nitrates	191-198	nitrate reductase 2	Arabidopsis thaliana	143-147
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	91-98	auxin signaling F-box 3	Arabidopsis thaliana	22-26
24642706-5	2014	Our work suggests two different signaling pathways may exist to control gene expression in response to nitrate downstream of NRT1.1.	Nitrates	103-110	nitrate transporter 1.1	Arabidopsis thaliana	125-131
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	91-98	NAC domain containing protein 80	Arabidopsis thaliana	31-35
24642706-0	2014	Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.	Nitrates	91-98	nitrate transporter 1.1	Arabidopsis thaliana	84-88
25187978-12	2014	In the group with ED, the serum level of endothelin 1 was higher compared with the group without ED (0.57 +-0.18 vs. 0.49 +-0.21 pg/ml; P = 0.032) and that of nitrates and nitrites was lower compared with the group without ED (15.2 [11.1-29.9] vs. 22.8 [16.9-33.0] mumol/l; P = 0.0005).	Nitrates	159-167	endothelin 1	Homo sapiens	41-53
25187978-14	2014	In the group with ED, PTH inversely correlated with nitrates and nitrites (R = -0.48; P = 0.003).	Nitrates	52-60	parathyroid hormone	Homo sapiens	22-25
25187978-15	2014	CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium.	Nitrates	194-202	parathyroid hormone	Homo sapiens	46-49
25187978-15	2014	CONCLUSIONS: In women with AH and without ED, PTH affected the production of a vasoconstrictor, endothelin 1, while in those with ED, PTH was associated with a lower production of vasodilators, nitrates and nitrites, by the vascular endothelium.	Nitrates	194-202	parathyroid hormone	Homo sapiens	134-137
23993458-3	2014	It has been demonstrated that ultrasound can produce NOx (nitrate and nitrite), with a production rate of 2.2 muM min(-1).	Nitrates	58-65	latexin	Homo sapiens	110-113
24212048-5	2013	Most delta(15)NNO3 values were within ranges expected for nitrate formed by ammonia nitrification in soil.	Nitrates	58-65	NNO3	Homo sapiens	14-18
23703110-5	2013	Using fish oil (0.0368 g EPA and 0.0184 g DHA, per day), melatonin (10 mg/kg/day), and vitamin E (50 mg/Kg/day) we have now shown that COX-2 activity, LPO and nitrite/nitrate levels were significantly increased in MPTP treated mice (p &lt; 0.001) while fish oil, melatonin and vitamin E treatment were capable of decreasing significantly the outcome of all above noted parameters (p &lt; 0.05).	Nitrates	167-174	cytochrome c oxidase II, mitochondrial	Mus musculus	135-140
24061044-3	2013	A detailed study of the nitrate derivative, based on the DFT analysis of the polarized spectra of single crystals, has been undertaken to propose the normal mode assignment of the Raman peaks in the low spin state of the compound.	Nitrates	24-31	spindlin 1	Homo sapiens	203-207
24094891-5	2013	SYN-PC positively co-related with nitrate and phosphate and SYN-PEI with phosphate.	Nitrates	34-41	synemin	Homo sapiens	0-3
23452999-9	2013	Nitrate loading obtained after nitrification, denitrification, and NO3 removal from unsaturated and shallow aquifer zones is combined with groundwater recharge.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
26328121-8	2013	The use of PDE-5 inhibitors is absolutely contraindicated in patients taking nitrate preparations.	Nitrates	77-84	phosphodiesterase 5A	Homo sapiens	11-16
24096001-4	2013	It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater.	Nitrates	64-71	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
24096001-4	2013	It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
24096001-4	2013	It was found that applying an electrical potential improved the nitrate removal and the highest nitrate removal rate of 208.2 +- 13.3g NO3(-)-Nm(-3) d(-1) was achieved at 0.8 V. Although the open circuit condition (no electricity generation) still resulted in a nitrate removal rate of 158.5 +- 4.2 gm(-3) d(-1) due to ion exchange, electricity production could inhibit ion exchange and prevent introducing other undesired ions into groundwater.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	135-138
23089892-9	2013	CART analysis showed that 30-day mortality among patients undergoing emergency CABG with unstable hemodynamic conditions was 32.60 % and it was 20.0 % in patients undergoing non-emergency operation with nitrates infusion at arrival in the operating room and left ventricular ejection fraction &lt;30 %.	Nitrates	203-211	CART prepropeptide	Homo sapiens	0-4
23645597-0	2013	Arabidopsis NRT1.1 is a bidirectional transporter involved in root-to-shoot nitrate translocation.	Nitrates	76-83	nitrate transporter 1.1	Arabidopsis thaliana	12-18
25518555-5	2013	We established that a NO scavenger, hemoglobin (4 muM), fully or partially removed the toxic effect of SNP, nitrate, and nitrite on growth.	Nitrates	108-115	latexin	Homo sapiens	50-53
23793091-7	2013	Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P&lt;0.05) in the outer layer.	Nitrates	21-28	S100 calcium binding protein B	Homo sapiens	51-54
23793091-7	2013	Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P&lt;0.05) in the outer layer.	Nitrates	21-28	S100 calcium binding protein B	Homo sapiens	70-73
23793091-7	2013	Residual nitrite and nitrate associated with fresh NEF and nitrate in NEF cooked LL were found (P&lt;0.05) in the outer layer.	Nitrates	59-66	S100 calcium binding protein B	Homo sapiens	70-73
23850530-6	2013	Acidosis and IL-1beta increased nitrite/nitrate release, but increases were moderate at 2% O2 and significantly reduced at &lt;1% O2.	Nitrates	40-47	interleukin 1 beta	Homo sapiens	13-21
23811105-6	2013	The activity of SOD and CAT decreased with the amount of nitrate and nitrite, while GSHPx and TBARS resulted unaffected.	Nitrates	57-64	catalase	Homo sapiens	24-27
24089435-0	2013	A reevaluation of the role of Arabidopsis NRT1.1 in high-affinity nitrate transport.	Nitrates	66-73	nitrate transporter 1.1	Arabidopsis thaliana	42-48
24028846-9	2013	35SPro:SWEET16 plants exhibited increased growth efficiency when cultivated on soil and showed improved nitrogen use efficiency when nitrate was sufficiently available, while under conditions of limiting nitrogen, wild-type biomasses were higher than those of 35SPro:SWEET16 plants.	Nitrates	133-140	Nodulin MtN3 family protein	Arabidopsis thaliana	7-14
24058148-1	2013	Cytokinin activity in plants is closely related to nitrogen availability, and an Arabidopsis gene for adenosine phosphate-isopentenyltransferase (IPT), IPT3, is regulated by inorganic nitrogen sources in a nitrate-specific manner.	Nitrates	206-213	isopentenyltransferase 3	Arabidopsis thaliana	152-156
24119003-5	2013	Our sequencing strategy identified new nitrate-regulated genes including 40 genes not represented in the ATH1 Affymetrix GeneChip, a novel nitrate-responsive antisense transcript and a new nitrate responsive miRNA/TARGET module consisting of a novel microRNA, miR5640 and its target, AtPPC3.	Nitrates	39-46	phosphoenolpyruvate carboxylase 3	Arabidopsis thaliana	284-290
24119003-5	2013	Our sequencing strategy identified new nitrate-regulated genes including 40 genes not represented in the ATH1 Affymetrix GeneChip, a novel nitrate-responsive antisense transcript and a new nitrate responsive miRNA/TARGET module consisting of a novel microRNA, miR5640 and its target, AtPPC3.	Nitrates	39-46	homeobox protein ATH1	Arabidopsis thaliana	105-109
23480350-0	2013	Regulation of nitrate reduction in Arabidopsis WT and hxk1 mutant under C and N metabolites.	Nitrates	14-21	hexokinase 1	Arabidopsis thaliana	54-58
23917809-8	2013	Side effects and interactions of PDE 5 inhibitors with other drugs have been minimal, with the exception of their coadministration with nitrates, which could lead to severe vasodilation and hypotension and therefore, their coadministration is prohibited.	Nitrates	136-144	phosphodiesterase 5A	Homo sapiens	33-38
23480350-1	2013	As in plants sugar sensing and signal transduction involve pathways dependent or independent on hexokinase 1 (HXK1) as a glucose sensor, research was conducted to determine which pathway is responsible for regulation of the nitrate reduction.	Nitrates	224-231	hexokinase 1	Arabidopsis thaliana	110-114
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	106-113	nitrate transporter 1.1	Arabidopsis thaliana	26-30
24006285-0	2013	Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth.	Nitrates	11-18	nitrate transporter 1.1	Arabidopsis thaliana	33-37
24006285-0	2013	Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth.	Nitrates	11-18	nitrate transporter 1.1	Arabidopsis thaliana	45-49
24006285-0	2013	Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth.	Nitrates	99-106	nitrate transporter 1.1	Arabidopsis thaliana	33-37
24006285-0	2013	Two phloem nitrate transporters, NRT1.11 and NRT1.12, are important for redistributing xylem-borne nitrate to enhance plant growth.	Nitrates	99-106	nitrate transporter 1.1	Arabidopsis thaliana	45-49
24006285-1	2013	This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth.	Nitrates	53-60	nitrate transporter 1.1	Arabidopsis thaliana	74-78
24006285-1	2013	This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth.	Nitrates	53-60	nitrate transporter 1.1	Arabidopsis thaliana	86-90
24006285-1	2013	This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth.	Nitrates	158-165	nitrate transporter 1.1	Arabidopsis thaliana	74-78
24006285-1	2013	This study of the Arabidopsis (Arabidopsis thaliana) nitrate transporters NRT1.11 and NRT1.12 reveals how the interplay between xylem and phloem transport of nitrate ensures optimal nitrate distribution in leaves for plant growth.	Nitrates	158-165	nitrate transporter 1.1	Arabidopsis thaliana	86-90
24006285-5	2013	In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues.	Nitrates	227-234	nitrate transporter 1.1	Arabidopsis thaliana	3-7
24006285-5	2013	In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues.	Nitrates	227-234	nitrate transporter 1.1	Arabidopsis thaliana	164-168
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	106-113	nitrate transporter 1.1	Arabidopsis thaliana	38-42
24006285-5	2013	In nrt1.11 nrt1.12 double mutants, more root-fed (15)NO3(-) was translocated to mature and larger expanded leaves but less to the youngest tissues, suggesting that NRT1.11 and NRT1.12 are required for transferring root-derived nitrate into phloem in the major veins of mature and larger expanded leaves for redistributing to the youngest tissues.	Nitrates	227-234	nitrate transporter 1.1	Arabidopsis thaliana	176-180
24006285-6	2013	Distinct from the wild type, nrt1.11 nrt1.12 double mutants show no increase of plant growth at high nitrate supply.	Nitrates	101-108	nitrate transporter 1.1	Arabidopsis thaliana	29-33
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	147-154	nitrate transporter 1.1	Arabidopsis thaliana	26-30
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	147-154	nitrate transporter 1.1	Arabidopsis thaliana	38-42
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	147-154	nitrate transporter 1.1	Arabidopsis thaliana	26-30
24006285-7	2013	These data suggested that NRT1.11 and NRT1.12 are involved in xylem-to-phloem transfer for redistributing nitrate into developing leaves, and such nitrate redistribution is a critical step for optimal plant growth enhanced by increasing external nitrate.	Nitrates	147-154	nitrate transporter 1.1	Arabidopsis thaliana	38-42
24270631-0	2013	The evolutionary events necessary for the emergence of symbiotic nitrogen fixation in legumes may involve a loss of nitrate responsiveness of the NIN transcription factor.	Nitrates	116-123	nin	Lotus japonicus	146-149
24270626-7	2013	This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis.	Nitrates	92-99	nitrate reductase 1	Arabidopsis thaliana	146-150
24270631-2	2013	NIN-like proteins (NLPs), which are presumably present in all land plants, were recently identified as key transcription factors in nitrate signaling and responses in Arabidopsis thaliana, a non-leguminous plant.	Nitrates	132-139	nin	Lotus japonicus	0-3
24270626-7	2013	This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis.	Nitrates	92-99	nitrite reductase 1	Arabidopsis thaliana	175-179
24270626-7	2013	This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis.	Nitrates	92-99	Plant regulator RWP-RK family protein	Arabidopsis thaliana	188-206
24270631-3	2013	Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs).	Nitrates	77-84	nin	Lotus japonicus	23-26
24270626-7	2013	This conserved motif, referred to here as NRE43-d8, was previously shown to be critical for nitrate-activated transcription of nitrate reductase (NIA1) and nitrite reductase (NIR1) by the NIN-LIKE PROTEIN 6 (NLP6) in Arabidopsis.	Nitrates	92-99	Plant regulator RWP-RK family protein	Arabidopsis thaliana	208-212
24270631-3	2013	Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs).	Nitrates	77-84	NLP1	Lotus japonicus	31-35
24270631-3	2013	Here we show that both NIN and NLP1 of L. japonicus (LjNLP1) can bind to the nitrate-responsive cis-element (NRE) and promote transcription from an NRE-containing promoter as did the NLPs of A. thaliana (AtNLPs).	Nitrates	77-84	NLP1	Lotus japonicus	53-59
24270631-5	2013	Thus, in the course of the evolution of NIN into a transcription factor that functions in nodulation in legumes, some mutations might arise that converted it to a nitrate-insensitive transcription factor.	Nitrates	163-170	nin	Lotus japonicus	40-43
24270631-6	2013	Because nodule formation is induced under nitrogen-deficient conditions, we speculate that the loss of the nitrate-responsiveness of NIN may be one of the evolutionary events necessary for the emergence of symbiotic nitrogen fixation in legumes.	Nitrates	107-114	nin	Lotus japonicus	133-136
23834222-5	2013	The first example of lead(II) borate nitrate, namely, [Pb3(B3O7)](NO3) (2), crystallizes in space group Pnma, and its structures features a 3D lead(II) borate cationic network structure in which (B3O7)(5-) anions are bridged by lead(II) cations, the nitrate anions are isolated, and located at the small voids of the cationic network.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
23820008-1	2013	Nitrate (NO3-) pollution in aquatic system is a worldwide problem.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
23734982-8	2013	Transcriptome analysis of homozygous viable nar1-4 seedlings showed transcriptional repression of a subset of genes involved in "iron ion transport" and "response to nitrate".	Nitrates	166-173	ferredoxin hydrogenase	Arabidopsis thaliana	44-48
23771693-0	2013	Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.	Nitrates	105-112	heme oxygenase 1	Mus musculus	126-142
23771693-1	2013	Previously we have shown that, unlike wild-type mice (WT), heme oxygenase-1 knockout (HO-1-/-) mice developed nitrate tolerance and were not protected from inflammation caused by ischemia-reperfusion (I/R) when preconditioned with a H2S donor.	Nitrates	110-117	heme oxygenase 1	Mus musculus	59-75
23514778-0	2013	Chemolithotrophic nitrate-dependent Fe(II)-oxidizing nature of actinobacterial subdivision lineage TM3.	Nitrates	18-25	tropomyosin 3	Homo sapiens	99-102
23943655-12	2013	In the unstable group, the total concentration of nitrite and nitrate at the last visit was 9.84 (6.65-11.24) muM.	Nitrates	62-69	latexin	Homo sapiens	110-113
23514778-4	2013	The incubations of sediment under chemolithotrophic nitrate-dependent Fe(II)-oxidizing conditions have shown the enrichment of TM3 group of uncultured Actinobacteria.	Nitrates	52-59	tropomyosin 3	Homo sapiens	127-130
23514778-11	2013	To the best of our knowledge this is the first study to show the autotrophic nitrate-dependent Fe(II)-oxidizing nature of TM3 group of uncultured Actinobacteria.	Nitrates	77-84	tropomyosin 3	Homo sapiens	122-125
23621281-5	2013	When N-deprived plants were fed via the roots with 15NO3 -, pgl3-1 exhibited normal induction of OPPP and nitrate assimilation genes in roots, and amino acids in roots and shoots were labeled with (15) N at least as rapidly as in the wild type.	Nitrates	106-113	NagB/RpiA/CoA transferase-like superfamily protein	Arabidopsis thaliana	60-64
23847199-0	2013	Systems approaches map regulatory networks downstream of the auxin receptor AFB3 in the nitrate response of Arabidopsis thaliana roots.	Nitrates	88-95	auxin signaling F-box 3	Arabidopsis thaliana	76-80
23739688-1	2013	The paralogous and functionally redundant GATA transcription factors GNC (for GATA, NITRATE-INDUCIBLE, CARBON-METABOLISM INVOLVED) and GNL/CGA1 (for GNC-LIKE/CYTOKININ-RESPONSIVE GATA FACTOR1) from Arabidopsis (Arabidopsis thaliana) promote greening and repress flowering downstream from the phytohormone gibberellin.	Nitrates	84-91	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	42-46
23847199-3	2013	We previously reported a role for AFB3 in coordinating primary and lateral root growth to nitrate availability.	Nitrates	90-97	auxin signaling F-box 3	Arabidopsis thaliana	34-38
23847199-4	2013	In this work, we used an integrated genomics, bioinformatics, and molecular genetics approach to dissect regulatory networks acting downstream of AFB3 that are activated by nitrate in roots.	Nitrates	173-180	auxin signaling F-box 3	Arabidopsis thaliana	146-150
23847199-5	2013	We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate.	Nitrates	86-93	NAC domain containing protein 80	Arabidopsis thaliana	18-22
23847199-5	2013	We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate.	Nitrates	86-93	NAC domain containing protein 80	Arabidopsis thaliana	123-127
23847199-5	2013	We found that the NAC4 transcription factor is a key regulatory element controlling a nitrate-responsive network, and that nac4 mutants have altered lateral root growth but normal primary root growth in response to nitrate.	Nitrates	215-222	NAC domain containing protein 80	Arabidopsis thaliana	123-127
23847199-7	2013	Our systems approach has unraveled key components of the AFB3 regulatory network leading to changes in lateral root growth in response to nitrate.	Nitrates	138-145	auxin signaling F-box 3	Arabidopsis thaliana	57-61
23683835-0	2013	Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.	Nitrates	21-29	aldo-keto reductase family 1 member B	Homo sapiens	69-85
23983629-5	2013	Comparisons between measured and simulated data indicated that the NO3-N concentrations in the soil and nitrate leaching to drains are controlled by the fertilizer practice, the initial conditions and the rainfall depth and distribution.	Nitrates	104-111	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
23820397-5	2013	In turn, this inflammatory response enhanced the luminal growth of E. coli by nitrate respiration in a Nos2-dependent fashion.	Nitrates	78-85	nitric oxide synthase 2, inducible	Mus musculus	103-107
23820397-9	2013	Here we show that streptomycin increases the inflammatory tone of the intestinal mucosa, thereby making the bowel more susceptible to dextran sulfate sodium treatment and boosting the Nos2-dependent growth of commensal Escherichia coli by nitrate respiration.	Nitrates	239-246	nitric oxide synthase 2, inducible	Mus musculus	184-188
23305042-0	2013	The nitrate transporter NRT2.1 functions in the ethylene response to nitrate deficiency in Arabidopsis.	Nitrates	4-11	nitrate transporter 2:1	Arabidopsis thaliana	24-30
23666325-5	2013	However, in the nitrate- and sulfate-plus-lactate-amended microcosms, soluble As levels decreased to 0.01 and 0.41 +- 0.13 muM, respectively, by the end of the experiment.	Nitrates	16-23	latexin	Homo sapiens	123-126
23395779-0	2013	Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes.	Nitrates	18-25	insulin	Homo sapiens	71-78
23395779-4	2013	We sought to determine if supplementing dietary nitrate with beetroot juice, a rich source of nitrate, will lower BP and improve endothelial function and insulin sensitivity in individuals with type 2 diabetes (T2DM).	Nitrates	48-55	insulin	Homo sapiens	154-161
23305042-3	2013	However, molecular interaction between NRT2.1 transcript levels and the ethylene signalling pathway under nitrate deficiency is still elusive.	Nitrates	106-113	nitrate transporter 2:1	Arabidopsis thaliana	39-45
23305042-2	2013	Previous studies have reported impact of high nitrate (HN) availability on ethylene biosynthesis and regulation of ethylene on nitrate transporter 2.1 (NRT2.1) expression.	Nitrates	46-53	nitrate transporter 2:1	Arabidopsis thaliana	127-150
23305042-5	2013	LN treatment also caused up-regulation of NRT2.1 expression, which was responsible for an enhanced high-affinity nitrate uptake.	Nitrates	113-120	nitrate transporter 2:1	Arabidopsis thaliana	42-48
23305042-2	2013	Previous studies have reported impact of high nitrate (HN) availability on ethylene biosynthesis and regulation of ethylene on nitrate transporter 2.1 (NRT2.1) expression.	Nitrates	46-53	nitrate transporter 2:1	Arabidopsis thaliana	152-158
23662623-1	2013	Under Fe(3+)-reducing conditions, soil Fe(2+) oxidation has been shown to be coupled with nitrate (NO3(-)) reduction.	Nitrates	90-97	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
23305042-8	2013	Together, these findings uncover a negative feedback loop between NRT2.1 expression and ethylene biosynthesis and signalling under nitrate deficiency, which may contribute to finely tuning of plant nitrate acquisition during exploring dynamic soil conditions.	Nitrates	131-138	nitrate transporter 2:1	Arabidopsis thaliana	66-72
23305042-8	2013	Together, these findings uncover a negative feedback loop between NRT2.1 expression and ethylene biosynthesis and signalling under nitrate deficiency, which may contribute to finely tuning of plant nitrate acquisition during exploring dynamic soil conditions.	Nitrates	198-205	nitrate transporter 2:1	Arabidopsis thaliana	66-72
23725033-3	2013	Nitrate is reduced at the Mo active site of NR, yielding the oxidized form of the enzyme, which is reactivated by the electro-reduced form of the mediator.	Nitrates	0-7	nitrate reductase 1	Arabidopsis thaliana	44-46
23356444-8	2013	Plasma nitrite/nitrate levels were lower in patients with CSX than control subjects (15.9 +- 1.6 mumol/L vs. 25.4 +- 2.8 mumol/L, respectively; P &lt; 0.001), and they have a significantly positive correlation with plasma adropin levels (r = 0.463, P &lt; 0.001).	Nitrates	15-22	NK2 homeobox 5	Homo sapiens	58-61
23470627-7	2013	Chronic inhibition of polyamine synthesis using an ornithine decarboxylase inhibitor significantly reduced polyamine levels, restored nitrite/nitrate levels to normal, and abrogated the AHR to methacholine in the acute model of allergic airways inflammation.	Nitrates	142-149	ornithine decarboxylase, structural 1	Mus musculus	51-74
23356444-9	2013	In the multiple linear regression analysis, nitrite/nitrate levels, BMI, and adropin were found to be independent risk factors for CSX.	Nitrates	52-59	NK2 homeobox 5	Homo sapiens	131-134
23590427-5	2013	Our results are consistent with a seed-specific response to seasonal temperature patterns (temporal sensing) involving the gene DELAY OF GERMINATION 1 (DOG1) that indicates the correct season, and concurrent temporally driven co-opted mechanisms that sense spatial signals, i.e. nitrate, via CBL-INTERACTING PROTEIN KINASE 23 (CIPK23) phosphorylation of the NITRATE TRANSPORTER 1 (NRT1.1), and light, via PHYTOCHROME A (PHYA).	Nitrates	279-286	delay of germination 1	Arabidopsis thaliana	152-156
24191599-5	2013	In river without highly circulating irrigation system or water gate effect, the downstream nitrate nitrogen (NO3-N) concentration increase occurred in area dominated by open field cultivation, whereas the NO3-N concentration was constant or decreased in area dominated by greenhouse land use.	Nitrates	91-98	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
24621868-3	2013	Some of the benefits seen with hydralazine, including afterload reduction and attenuation of nitrate tolerance, have also been observed with angiotensin-converting enzyme inhibitors.	Nitrates	93-100	angiotensin I converting enzyme	Homo sapiens	141-170
24621868-4	2013	Demonstrating similar clinical benefits with nitrates plus angiotensin-converting enzyme inhibitor therapy alone, in the absence of hydralazine, may represent an opportunity to improve heart failure care by increasing the use of nitrates.	Nitrates	229-237	angiotensin I converting enzyme	Homo sapiens	59-88
23713126-2	2013	Leakages from the use of fertilizer Nr contribute to nitrate (NO3(-)) in drainage waters from agricultural land and emissions of trace Nr compounds to the atmosphere.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
23759982-1	2013	Extending our previous observations, we have shown on HaCat cells that melatonin, at ~10-9 M concentration, transiently raises not only the expression of the neuronal nitric oxide synthase (nNOS) mRNA, but also the nNOS protein synthesis and the nitric oxide oxidation products, nitrite and nitrate.	Nitrates	291-298	nitric oxide synthase 1	Homo sapiens	190-194
23536322-11	2013	NaK-Ni7-Ale2 proved to be efficient for the electrocatalytic reduction of nitrate, nitrite and nitrous oxide.	Nitrates	74-81	TANK binding kinase 1	Homo sapiens	0-3
23376235-7	2013	In the 27 patients on dialysis, baseline plasma nitrite and nitrate by HPLC were 0.21+-0.03 and 67.25+-14.68 muM, respectively.	Nitrates	60-67	latexin	Homo sapiens	109-112
23589565-9	2013	Our observations demonstrate the improved efficacy of inorganic nitrate and nitrite in hypertension as a consequence of increased erythrocytic XOR nitrite reductase activity and support the concept of dietary nitrate supplementation as an effective, but simple and inexpensive, antihypertensive strategy.	Nitrates	64-71	xanthine dehydrogenase	Homo sapiens	143-146
23515834-8	2013	According to Canonical Correspondence Analysis, pH, temperature, nitrite, and nitrate concentration strongly affected the diversity and distribution of anammox bacteria in South China Sea sediments.	Nitrates	78-85	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	184-187
23394787-0	2013	Response to nitrate/ammonium nutrition of tomato (Solanum lycopersicum L.) plants overexpressing a prokaryotic NH4(+)-dependent asparagine synthetase.	Nitrates	12-19	asparagine synthetase	Solanum lycopersicum	128-149
23378445-11	2013	CONCLUSIONS: Ex vivo thrombin generation was associated with exposure to NO2, nitrate and sulphate, but not PM mass, PM OP or other measured air pollutants.	Nitrates	78-85	coagulation factor II, thrombin	Homo sapiens	21-29
23463757-10	2013	ATbG-NOS3 haplotype homozygosity was associated with up to 64% higher nitrite/nitrate levels (P=0.003).	Nitrates	78-85	nitric oxide synthase 3	Homo sapiens	5-9
23467180-4	2013	High riverine concentrations of nitrate (NO3; up to 220 muM) and phosphate (PO4; up to 3.7 muM) mainly originated from agricultural fertilizer input.	Nitrates	32-39	latexin	Homo sapiens	56-59
23386129-3	2013	Blockade of Mas with its antagonist A-779 in Bdkrb2(-/-) shortens thrombosis times (58 +- 4 minutes to 38 +- 4 minutes) and bleeding times (170 +- 13 seconds to 88 +- 8 seconds) and lowers plasma nitrate (22 +- 4 muM to 15 +- 5 muM), and 6-keto-PGF1alpha (259 +- 103 pg/mL to 132 +- 58 pg/mL).	Nitrates	196-203	bradykinin receptor, beta 2	Mus musculus	45-51
23194305-10	2013	The results support the view that impaired ALDH2-catalysed metabolism of GTN contributes significantly to the development of vascular nitrate tolerance and reveal a hitherto unrecognized protective effect of ascorbate in the vasculature.	Nitrates	134-141	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	43-48
23441627-8	2013	The high NOS-2 expression coincided with an exacerbated NO production in the infection focus and in plasma, as judging by nitrate + nitrite levels.	Nitrates	122-129	nitric oxide synthase 2, inducible	Mus musculus	9-14
23398541-8	2013	Using a nitrate reductase mutant, it was confirmed that the NRT2.5/NRT2.6-dependent plant signalling pathway is independent of nitrate-dependent regulation of root development.	Nitrates	8-15	nitrate transporter 2:1	Arabidopsis thaliana	60-64
23398541-8	2013	Using a nitrate reductase mutant, it was confirmed that the NRT2.5/NRT2.6-dependent plant signalling pathway is independent of nitrate-dependent regulation of root development.	Nitrates	8-15	nitrate transporter 2:1	Arabidopsis thaliana	67-71
23307651-1	2013	Plant nitrate (NO3(-)) acquisition depends on the combined activities of root high- and low-affinity NO3(-) transporters and the proton gradient generated by the plasma membrane H(+)-ATPase.	Nitrates	6-13	plasma membrane H+-ATPase	Arabidopsis thaliana	162-189
23461818-1	2013	Aqueous nitrate, NO3(-)(aq), was studied by 2D-IR, UV-IR, and UV-UV time-resolved spectroscopies in combination with molecular dynamics (MD) simulations with the purpose of determining the hydration dynamics around the anion.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
23387982-1	2013	In the atmosphere, mineral dust particles are often associated with adsorbed nitrate from heterogeneous reactions with nitrogen oxides (N2O5, HNO3, NO3, and NO2).	Nitrates	77-84	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
23276425-4	2013	Titanium dioxide (Evonik P90), acting as photocatalyst, reduced nitrate effectively in both synthetic brines and sulfate-removed IX brine when formic acid (FA) was used as the hole scavenger (i.e., electron donor) and the initial FA to nitrate molar ratio (IFNR) was 5.6.	Nitrates	64-71	cellular inhibitor of PP2A	Homo sapiens	25-28
23250328-7	2013	Our system shows good correlation with controls up to 50 muM of nitrate, which adequately covers the healthy human range (4 to 45.3 muM).	Nitrates	64-71	latexin	Homo sapiens	57-60
23276425-4	2013	Titanium dioxide (Evonik P90), acting as photocatalyst, reduced nitrate effectively in both synthetic brines and sulfate-removed IX brine when formic acid (FA) was used as the hole scavenger (i.e., electron donor) and the initial FA to nitrate molar ratio (IFNR) was 5.6.	Nitrates	236-243	cellular inhibitor of PP2A	Homo sapiens	25-28
23276425-6	2013	In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles.	Nitrates	28-35	cellular inhibitor of PP2A	Homo sapiens	156-159
23276425-6	2013	In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles.	Nitrates	28-35	cellular inhibitor of PP2A	Homo sapiens	187-190
23276425-6	2013	In a non-modified IX brine, nitrate removal was greatly inhibited owing to the presence of sulfate, which competed with nitrate for active surface sites on P90 and induced aggregation of P90 nanoparticles.	Nitrates	120-127	cellular inhibitor of PP2A	Homo sapiens	156-159
23250328-7	2013	Our system shows good correlation with controls up to 50 muM of nitrate, which adequately covers the healthy human range (4 to 45.3 muM).	Nitrates	64-71	latexin	Homo sapiens	132-135
23262000-5	2013	With adjustment of hydraulic retention time (HRT), the highest of nitrate removal efficiency (74.2+-1.4%) and organics utilization efficiency (0.63 mg NO3--N mg(-1)TOC) were achieved at an optimum HRT of 18 h, with both low effluent NO3--N (0.88+-0.03 mg l(-1)) and TOC (2.86+-0.67 mg l(-1)).	Nitrates	66-73	NBL1, DAN family BMP antagonist	Homo sapiens	233-236
23288160-8	2013	Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P&lt;0.001) and higher nitrite/nitrate (P&lt;0.001), whereas platelets from obese women had higher isoprostanes (P&lt;0.001) and lower nitrite/nitrate (P=0.013).	Nitrates	149-156	cytochrome b-245 beta chain	Homo sapiens	78-82
23288160-8	2013	Ex vivo study showed that, compared with controls, platelets from carriers of NOX2 deficiency had lower isoprostanes (P&lt;0.001) and higher nitrite/nitrate (P&lt;0.001), whereas platelets from obese women had higher isoprostanes (P&lt;0.001) and lower nitrite/nitrate (P=0.013).	Nitrates	261-268	cytochrome b-245 beta chain	Homo sapiens	78-82
23279126-10	2013	A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively.	Nitrates	34-41	nitric oxide synthase, brain	Cavia porcellus	197-201
22994391-1	2013	BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation.	Nitrates	145-153	aldehyde dehydrogenase 2 family member	Homo sapiens	66-90
22994391-1	2013	BACKGROUND AND PURPOSE: Recent studies suggest a primary role for aldehyde dehydrogenase 2 (ALDH2) in mediating the biotransformation of organic nitrates, such as glyceryl trinitrate (GTN), to the proximal activator of soluble guanylyl cyclase (sGC), resulting in increased cGMP accumulation and vasodilation.	Nitrates	145-153	aldehyde dehydrogenase 2 family member	Homo sapiens	92-97
22994391-2	2013	Our objective was to assess the role of ALDH2 in organic nitrate action using a cell culture model.	Nitrates	57-64	aldehyde dehydrogenase 2 family member	Homo sapiens	40-45
23149826-8	2013	Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine.	Nitrates	301-308	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	40-88
23149826-8	2013	Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPARgamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine.	Nitrates	301-308	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	90-99
23279126-10	2013	A significant increase of nitrite/nitrate levels was observed in the first 5 min after inducing I/R and was significantly reduced by N(omega) -propyl-l-arginine and 1400 W, selective inhibitors of nNOS and iNOS, respectively.	Nitrates	34-41	nitric oxide synthase, inducible	Cavia porcellus	206-210
23200251-4	2013	hCA VIII was poorly inhibited by halides, cyanate, nitrate and sulfate (K(I)s of 38.4-65.4 mM), whereas CA XI had a behavior intermediate between that of hCA VIII and X, both regarding the catalytic activity and sensitivity to anion inhibitors.	Nitrates	51-58	carbonic anhydrase 8	Homo sapiens	0-8
23215531-2	2013	The detection of vapors from the low volatility explosive compound RDX was achieved through selective atmospheric pressure chemical ionization using nitrate reactant ions (NO(3)(-)) and NO(3)(-) HNO(3) adducts generated in an electrical discharge source.	Nitrates	149-156	radixin	Homo sapiens	67-70
23215531-6	2013	Recorded signals were observed for RDX concentrations below 25 ppq using selected ion monitoring (SIM) of the RDX-nitrate adduct at m/z 284.	Nitrates	114-121	radixin	Homo sapiens	35-38
23215531-6	2013	Recorded signals were observed for RDX concentrations below 25 ppq using selected ion monitoring (SIM) of the RDX-nitrate adduct at m/z 284.	Nitrates	114-121	radixin	Homo sapiens	110-113
24396568-4	2013	TNF-alpha increased the levels of superoxide, Nox (nitrate and nitrite), malondialdehyde, and nitrotyrosine production, accompanied by increased protein expression of p-PKC-beta2, gP91phox, and endothelial cell apoptosis, whereas all these changes were further enhanced by nitroglycerine.	Nitrates	51-58	tumor necrosis factor	Homo sapiens	0-9
23008504-8	2013	However, the level of nitrate and nitrite, substrates of cytochrome P450 reductase, were higher in SHR than WKY plasma and aortae.	Nitrates	22-29	cytochrome p450 oxidoreductase	Rattus norvegicus	57-82
24396568-0	2013	Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-alpha: the role of PKC-beta2 and NADPH oxidase.	Nitrates	23-30	tumor necrosis factor	Homo sapiens	106-115
23004358-0	2013	The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7.	Nitrates	13-20	TIR-NBS-LRR class disease resistance protein	Arabidopsis thaliana	76-80
23004358-0	2013	The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7.	Nitrates	13-20	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	94-98
23004358-0	2013	The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7.	Nitrates	13-20	nudix hydrolase homolog 6	Arabidopsis thaliana	125-130
23111423-1	2013	A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance.	Nitrates	171-178	aldehyde dehydrogenase 2 family member	Homo sapiens	36-60
23111423-1	2013	A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance.	Nitrates	171-178	aldehyde dehydrogenase 2 family member	Homo sapiens	62-67
23004358-0	2013	The ammonium/nitrate ratio is an input signal in the temperature-modulated, SNC1-mediated and EDS1-dependent autoimmunity of nudt6-2 nudt7.	Nitrates	13-20	MutT/nudix family protein	Arabidopsis thaliana	133-138
23111423-1	2013	A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance.	Nitrates	171-178	superoxide dismutase 2	Homo sapiens	73-95
23111423-1	2013	A cooperative role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) and superoxide dismutase 2 (SOD2) to maintain the vascular function has recently been demonstrated in nitrate tolerance.	Nitrates	171-178	superoxide dismutase 2	Homo sapiens	97-101
23004358-7	2013	We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity.	Nitrates	29-36	nudix hydrolase homolog 6	Arabidopsis thaliana	136-141
23004358-7	2013	We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity.	Nitrates	29-36	MutT/nudix family protein	Arabidopsis thaliana	144-149
23004358-7	2013	We found that a low ammonium/nitrate ratio in growth media leads to a higher level of nitrite-dependent nitric oxide (NO) production in nudt6-2 nudt7, and NO acts in a positive feedback loop with EDS1 to promote the autoimmunity.	Nitrates	29-36	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	196-200
23004358-8	2013	The low ammonium/nitrate ratio also enhances autoimmunity in snc1-1 and cpr1, two other autoimmune mutants in Arabidopsis.	Nitrates	17-24	TIR-NBS-LRR class disease resistance protein	Arabidopsis thaliana	61-67
23004358-8	2013	The low ammonium/nitrate ratio also enhances autoimmunity in snc1-1 and cpr1, two other autoimmune mutants in Arabidopsis.	Nitrates	17-24	F-box and associated interaction domains-containing protein	Arabidopsis thaliana	72-76
23004358-9	2013	Our study indicates that Arabidopsis senses the ammonium/nitrate ratio as an input signal to determine the amplitude of the EDS1-mediated defense response, probably through the modulation of NO production.	Nitrates	57-64	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	124-128
24084651-3	2013	We hypothesized that the competition between nitrate and ABA as substrates for AtNPF4.6 might be involved in the interactions between nitrate and ABA signaling.	Nitrates	45-52	nitrate transporter 1:2	Arabidopsis thaliana	79-87
24084651-3	2013	We hypothesized that the competition between nitrate and ABA as substrates for AtNPF4.6 might be involved in the interactions between nitrate and ABA signaling.	Nitrates	134-141	nitrate transporter 1:2	Arabidopsis thaliana	79-87
24084651-5	2013	In addition, the npf4.6 mutant was less sensitive to ABA than the wild type during germination irrespective of nitrate concentrations in the media.	Nitrates	111-118	nitrate transporter 1:2	Arabidopsis thaliana	17-23
24084651-6	2013	Furthermore, nitrate promoted germination of both wild type and npf4.6 in the presence of ABA.	Nitrates	13-20	nitrate transporter 1:2	Arabidopsis thaliana	64-70
23469284-13	2013	Plasma nitrate/nitrite level was significantly reduced in AngII-infused mice (P&lt;0.05).	Nitrates	7-14	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	58-63
23199690-4	2013	The pdr1 mutant has proved potentially useful in understanding the responses to nitrate (Ni), P and cytokinin.	Nitrates	80-87	pleiotropic drug resistance 1	Arabidopsis thaliana	4-8
23342065-6	2013	We further demonstrate that the exported POC:PON ratio varies regionally in relation to nitrate-based new production over geographical scales that range from the Arctic to the subtropics, being highest in the least productive oligotrophic Central Arctic Ocean and subtropical gyres.	Nitrates	88-95	paraoxonase 1	Homo sapiens	45-48
23651488-2	2013	The aim of the present study was to analyze concentrations of nitrates and nitrites (NO2 + NO3) and L-arginine in patients with liver cirrhosis and HRS as a possible predictive marker for the development of HRS.	Nitrates	62-70	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
23231781-8	2012	We also found consistent inverse associations of vWF with nitrate, chloride and sodium, and sP-selectin with manganese.	Nitrates	58-65	von Willebrand factor	Homo sapiens	49-52
22961095-6	2013	The iNOS inhibitors significantly inhibited the acrolein-increased nitrite/nitrate levels, but not IL-6 levels.	Nitrates	75-82	nitric oxide synthase 2	Rattus norvegicus	4-8
23230319-0	2012	Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase".	Nitrates	45-52	nitric oxide synthase 3	Homo sapiens	113-146
22811030-8	2012	Plasma ET-1 increased significantly (P &lt; 0.05) just after exercise in nitrate (4.0 +- 0.8 pg mL) and placebo (2.4 +- 0.4 pg mL) conditions.	Nitrates	73-80	endothelin 1	Homo sapiens	7-11
23230319-0	2012	Letter by Tsikas regarding article, "dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase".	Nitrates	45-52	thioredoxin reductase 1	Homo sapiens	160-175
23038808-5	2012	Here we determine the potential of marine prokaryotes from different sediments of the Atlantic Ocean and Mediterranean Sea to couple nitrate reduction to the oxidation of aromatic hydrocarbons.	Nitrates	133-140	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	119-122
22796369-5	2012	KEY FINDINGS: In the presence of high concentrations of fibrinogen and ACh (10 muM) in the blood samples from healthy humans the erythrocyte nitrites, nitrates and GSNO concentrations increased without significant changes in NO efflux.	Nitrates	151-159	fibrinogen beta chain	Homo sapiens	56-66
23062112-2	2012	Cefazolin (CFZ) and cephapirin (CFP) underwent mainly direct photolysis (t(1/2) = 0.7, 3.9 h), while cephalexin (CFX) and cephradine (CFD) were mainly transformed by indirect photolysis, which during the process a bicarbonate-enhanced nitrate system contributed most to the loss rate of CFX, CFD, and cefotaxime (CTX) (t(1/2) = 4.5, 5.3, and 1.3 h, respectively).	Nitrates	235-242	complement factor properdin	Homo sapiens	32-35
22988236-6	2012	Assuming that the structures of the triple mutant and wild-type ALDH2 reflect binding of GTN to the catalytic site and the first reaction step, respectively, superposition of the two structures indicates that denitration of GTN is initiated by nucleophilic attack of Cys-302 at one of the terminal nitrate groups, resulting in formation of the observed thionitrate intermediate and release of 1,2-glyceryl dinitrate.	Nitrates	298-305	aldehyde dehydrogenase 2 family member	Homo sapiens	64-69
22982594-8	2012	PPARdelta activation increased the total nitrite and nitrate (NO2+NO3) content in cerebral microvessels (P&lt;0.05, n=6).	Nitrates	53-60	peroxisome proliferator activator receptor delta	Mus musculus	0-9
22988236-7	2012	Our results shed light on the molecular mechanism of the GTN denitration reaction and provide useful information on the structural requirements for high affinity binding of organic nitrates to the catalytic site of ALDH2.	Nitrates	181-189	aldehyde dehydrogenase 2 family member	Homo sapiens	215-220
22683098-6	2012	RESULTS: We found that serum tNOx (total nitrite/nitrate; mumol/L) was lower in obese T2DM group (12.7+-3.5) when compared with their controls (21.1+-2.4), although the non-obese group presented higher concentration of tNOx (33.8+-7.2).	Nitrates	49-56	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	29-33
22858636-2	2012	Of the NRT1(PTR) members known to transport nitrate, most are low-affinity transporters.	Nitrates	44-51	nitrate transporter 1.1	Arabidopsis thaliana	7-11
22992322-9	2012	Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue.	Nitrates	8-15	CD34 antigen	Mus musculus	116-120
22992322-9	2012	Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue.	Nitrates	8-15	kinase insert domain protein receptor	Mus musculus	124-129
22992322-9	2012	Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue.	Nitrates	8-15	platelet/endothelial cell adhesion molecule 1	Mus musculus	170-174
22992322-9	2012	Dietary nitrate increased plasma S-nitrosothiols and nitrite, enhanced revascularization, increased mobilization of CD34(+)/Flk-1(+) and migration of bone marrow-derived CD31(+)/CD45(-) cells to the site of ischemia, and attenuated apoptosis of potentially regenerative myoblasts in chronically ischemic tissue.	Nitrates	8-15	protein tyrosine phosphatase, receptor type, C	Mus musculus	178-182
22790675-0	2012	Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data.	Nitrates	82-89	arginine deiminase	Escherichia coli	47-51
22858636-4	2012	Heterologous expression experiments showed that MtNIP/LATD encodes a nitrate transporter: expression in Xenopus laevis oocytes conferred upon the oocytes the ability to take up nitrate from the medium with high affinity, and expression of MtNIP/LATD in an Arabidopsis chl1(nrt1.1) mutant rescued the chlorate susceptibility phenotype.	Nitrates	69-76	nitrate transporter 1.1	Arabidopsis thaliana	273-277
22935372-3	2012	Coulometric analysis with the tubular membrane ISE showed that nitrate could be detected in the range 10-100 muM with a precision of 2.3% relative standard deviation (RSD), limit of detection of 1.1 muM and relative accuracy of 4.4% compared to a certified reference material (CRM) Lake sample.	Nitrates	63-70	latexin	Homo sapiens	109-112
22935372-3	2012	Coulometric analysis with the tubular membrane ISE showed that nitrate could be detected in the range 10-100 muM with a precision of 2.3% relative standard deviation (RSD), limit of detection of 1.1 muM and relative accuracy of 4.4% compared to a certified reference material (CRM) Lake sample.	Nitrates	63-70	latexin	Homo sapiens	199-202
22795587-1	2012	Zero-valent iron (Fe(0))-based permeable reactive barrier (PRB) technology has been proved to be effective for soil and groundwater nitrate remediation under acidic or near neutral conditions.	Nitrates	132-139	RB transcriptional corepressor 1	Homo sapiens	59-62
22819707-3	2012	The daily administration of L-NAME (50mg/kg) for six weeks along with DADS analogs (20 mg/kg) significantly decreased the elevated systolic blood pressure (SBP) and the activity of angiotensin converting enzyme (ACE) and also inhibited the decline in nitrite/nitrate (NO(x)) concentrations and cyclic guanosine monophosphate (cGMP) levels.	Nitrates	259-266	angiotensin I converting enzyme	Rattus norvegicus	212-215
22795587-10	2012	The results implied that PRB based Fe(0) is a potential approach for in situ remediation of soil and groundwater nitrate contamination in the alkaline conditions.	Nitrates	113-120	RB transcriptional corepressor 1	Homo sapiens	25-28
22810276-3	2012	Co(II) is hepta-coordinated by three N atoms from the bpy units, and four O atoms from two nitrate groups.	Nitrates	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
22530997-3	2012	This study utilized experimental vernal pool microcosms to simulate persistent pH alteration and a pulse input of nitrate (NO3 -), which are common perturbations to temperate vernal pool ecosystems.	Nitrates	114-121	NBL1, DAN family BMP antagonist	Homo sapiens	123-126
22845863-8	2012	Finally, XPS analysis confirms that NO2 adsorbs on CaCO3 (1014) in the form of nitrate (NO3(-)) regardless of environmental conditions or the pretreatment of the calcite surface at different relative humidity.	Nitrates	79-86	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
23031518-5	2012	In consistent with previous findings, catalase has been shown to play a major role in modulating the nitrosative stress by oxidizing nitrite to nitrate.	Nitrates	144-151	catalase	Bos taurus	38-46
24501070-1	2012	Nitrate (NO3 (-) ) export coupled with high inorganic nitrogen (N) concentrations in Alaskan streams suggests that N cycles of permafrost-influenced ecosystems are more open than expected for N-limited ecosystems.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Nitrates	8-15	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Nitrates	8-15	CD59 molecule (CD59 blood group)	Homo sapiens	179-185
23240214-3	2012	Optimum nitrate reduction rate (1.03 +/- 0.087 x 10(-4) mol x min(-1) x greduc(-1)) was obtained with 5.0% nano-scale Fe/Ni, while only 25% nitrate (1.05 +/- 0.091 x 10(-5) mol x min(-1) x greduc(-1)) was transformed by nano-scale Fe(0) within the same reaction time, which means that these bimetallic nanoparticles are obviously more reactive than monometallic nano-scale Fe(0).	Nitrates	140-147	CD59 molecule (CD59 blood group)	Homo sapiens	62-68
22833666-6	2012	In contrast, an increased supply of nitrate stimulated NR activity and NO production, and enhanced SM and decreased SG levels in both genotypes.	Nitrates	36-43	nitrate reductase 1	Arabidopsis thaliana	55-57
22715856-5	2012	The analysis was performed with the enzyme in its ligand-free and MgADP-complexed forms, as well as with the transition-state analogue abortive complex (MCK-Mg-ADP-creatine-nitrate ion).	Nitrates	173-180	creatine kinase, M-type	Homo sapiens	153-156
22778404-11	2012	Taken together, these data demonstrate that sialin mediates nitrate influx into salivary gland and other cell types.	Nitrates	60-67	solute carrier family 17 member 5	Homo sapiens	44-50
22778404-12	2012	We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis.	Nitrates	134-141	solute carrier family 17 member 5	Homo sapiens	57-63
22778404-12	2012	We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis.	Nitrates	154-161	solute carrier family 17 member 5	Homo sapiens	57-63
22969780-3	2012	Currently, the association of vitamin D (25-hydroxyvitamin D, 25-OH D) and PTH to nitric oxide metabolites (NOx) - nitrate and nitrite - and oxidative stress in African-Americans is unknown.	Nitrates	115-122	parathyroid hormone	Homo sapiens	75-78
22687611-6	2012	These changes in nitrate treated mice were accompanied by increased expression of the Ca(2+) handling proteins calsequestrin 1 and the dihydropyridine receptor.	Nitrates	17-24	calsequestrin 1	Mus musculus	111-126
22344735-9	2012	Taken together, this study has shown for first time that peroxynitrites can nitrate and activate MMP-2 and MMP-9 in the placenta, a nitrative pathway possibly related to MMPs overactivity in the placentas from type 2 diabetic patients.	Nitrates	76-83	matrix metallopeptidase 9	Homo sapiens	107-112
22344735-9	2012	Taken together, this study has shown for first time that peroxynitrites can nitrate and activate MMP-2 and MMP-9 in the placenta, a nitrative pathway possibly related to MMPs overactivity in the placentas from type 2 diabetic patients.	Nitrates	76-83	matrix metallopeptidase 2	Homo sapiens	170-174
22497785-4	2012	The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1).	Nitrates	50-57	MuLV-induced myeloid leukemia 1	Mus musculus	108-114
22685171-1	2012	Nitrate reallocation to plant roots occurs frequently under adverse conditions and was recently characterized to be actively regulated by Nitrate Transporter1.8 (NRT1.8) in Arabidopsis (Arabidopsis thaliana) and implicated as a common response to stresses.	Nitrates	0-7	NITRATE TRANSPORTER 1.8	Arabidopsis thaliana	138-160
22685171-1	2012	Nitrate reallocation to plant roots occurs frequently under adverse conditions and was recently characterized to be actively regulated by Nitrate Transporter1.8 (NRT1.8) in Arabidopsis (Arabidopsis thaliana) and implicated as a common response to stresses.	Nitrates	0-7	NITRATE TRANSPORTER 1.8	Arabidopsis thaliana	162-168
22685171-5	2012	Further analyses showed that nitrate, as well as Na(+) and Cd(2+) levels, were significantly increased in nrt1.5 roots.	Nitrates	29-36	nitrate transporter 1.1	Arabidopsis thaliana	106-110
22685171-8	2012	These data suggest that NRT1.5 is involved in nitrate allocation to roots and the consequent tolerance to several stresses, in a mechanism probably shared with NRT1.8.	Nitrates	46-53	nitrate transporter 1.1	Arabidopsis thaliana	24-28
22497785-4	2012	The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1).	Nitrates	50-57	MuLV-induced myeloid leukemia 1	Mus musculus	122-128
22497785-4	2012	The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1).	Nitrates	91-98	MuLV-induced myeloid leukemia 1	Mus musculus	108-114
22497785-4	2012	The photodegradation was found to be dependent on nitrate concentration and increasing the nitrate from 0.5 mML(-1) to 10 mML(-1) led to the enhancement of rate constant from 0.00101 min(-1) to 0.00716 min(-1).	Nitrates	91-98	MuLV-induced myeloid leukemia 1	Mus musculus	122-128
22572914-0	2012	Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.	Nitrates	8-15	nitric oxide synthase 3, endothelial cell	Mus musculus	76-109
22588047-1	2012	Acute dietary nitrate (NO3-) supplementation has been reported to lower resting blood pressure, reduce the oxygen (O2) cost of sub-maximal exercise, and improve exercise tolerance.	Nitrates	14-21	NBL1, DAN family BMP antagonist	Homo sapiens	23-26
22572914-0	2012	Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase.	Nitrates	8-15	xanthine dehydrogenase	Mus musculus	114-137
22572914-7	2012	The beneficial effects of dietary nitrate and nitrite were reduced in mice lacking endothelial NO synthase or treated with the xanthine oxidoreductase inhibitor allopurinol.	Nitrates	34-41	xanthine dehydrogenase	Mus musculus	127-150
21932058-2	2012	The study was tested in a fecal peritonitis-induced septic shock model, we observed that levosimendan combined with arginine vasopressin supplemented with norepinephrine therapy resulted in lower mean pulmonary artery pressure, lactate concentrations, arterial total nitrate/nitrite, and high-mobility group box 1 levels; decreased lung wet/dry ratio, and pulmonary levels of interleukin-6, total histological scores, and improved pulmonary gas exchange when compared with norepinephrine group.	Nitrates	267-274	arginine vasopressin	Homo sapiens	125-136
22732219-4	2012	The addition of nitrate or ammonium resulted in a decrease or an increase in the expression of the same gene families, respectively, in both wild-type and siz1-2 mutants.	Nitrates	16-23	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	155-159
22493305-0	2012	Transcriptional regulation of nitrate assimilation in Pseudomonas aeruginosa occurs via transcriptional antitermination within the nirBD-PA1779-cobA operon.	Nitrates	30-37	assimilatory nitrate reductase	Pseudomonas aeruginosa PAO1	137-143
22493305-1	2012	Bioinformatic approaches employed to analyse intergenic regions of Pseudomonas aeruginosa O1 (PAO1) for small RNAs (sRNAs) revealed a putative RNA gene encoded upstream of the nitrate assimilation operon nirBD-PA1779-cobA.	Nitrates	176-183	assimilatory nitrate reductase	Pseudomonas aeruginosa PAO1	210-216
22523192-0	2012	Overexpressing the ANR1 MADS-box gene in transgenic plants provides new insights into its role in the nitrate regulation of root development.	Nitrates	102-109	AGAMOUS-like 44	Arabidopsis thaliana	19-23
22571503-0	2012	Nitrate transport in cucumber leaves is an inducible process involving an increase in plasma membrane H+-ATPase activity and abundance.	Nitrates	0-7	plasma membrane ATPase 4	Cucumis sativus	86-111
22475571-7	2012	Nitrate and reactive oxygen species were greater in Salmonella-infected HD11 cells with the expression of iNOS and nuclear factor-kappaB by chicken macrophages infected with both systemic and broad host range serovars.	Nitrates	0-7	nitric oxide synthase 2	Gallus gallus	106-110
22571503-10	2012	Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake.	Nitrates	127-134	plasma membrane ATPase 4	Cucumis sativus	82-87
22571503-10	2012	Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake.	Nitrates	127-134	high affinity nitrate transporter 2.4-like	Cucumis sativus	93-97
22571503-10	2012	Molecular analyses suggest the involvement of a specific isoform of PM H+-ATPase (CsHA1) and NRT2 transporter (CsNRT2) in root nitrate uptake.	Nitrates	127-134	high affinity nitrate transporter 2.4-like	Cucumis sativus	111-117
22571503-11	2012	At the leaf level, nitrate treatment modulated the expression of CsHA2, highlighting a main putative role of this isogene in the process.	Nitrates	19-26	plasma membrane ATPase 4	Cucumis sativus	65-70
22406434-9	2012	Nitrate ingestion led to a rise in plasma nitrite together with an acute increase in CD34(+)/KDR(+) and CD133(+)/KDR(+)-CACs along with increased NOS-dependent vasodilation.	Nitrates	0-7	CD34 antigen	Mus musculus	85-89
22860400-4	2012	The per os administration of the NSE aqueous suspension in a dose of 50 mg/kg during 10 days to the rats with induced diabetes contributed to the normalization of catalase activity in the testis, which correlated with a decrease in the amount of TBA-reacting products and activity of superoxide dismutase and catalase in the blood plasma of animals; the use of NSE also contributed to the reduction of nitrite content in the gonads and to normalization of both nitrite and nitrate in the blood plasma of rats.	Nitrates	473-480	enolase 2	Rattus norvegicus	33-36
22432443-0	2012	Nitrate transport capacity of the Arabidopsis thaliana NRT2 family members and their interactions with AtNAR2.1.	Nitrates	0-7	nitrate transporter 2:1	Arabidopsis thaliana	55-59
22432443-1	2012	Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots.	Nitrates	72-79	nitrate transporter 2:1	Arabidopsis thaliana	58-66
22432443-1	2012	Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots.	Nitrates	72-79	nitrate transmembrane transporter	Arabidopsis thaliana	134-142
22432443-1	2012	Interactions between the Arabidopsis NitRate Transporter (AtNRT2.1) and Nitrate Assimilation Related protein (AtNAR2.1, also known as AtNRT3.1) have been well documented, and confirmed by the demonstration that AtNRT2.1 and AtNAR2.1 form a 150-kDa plasma membrane complex, thought to constitute the high-affinity nitrate transporter of Arabidopsis thaliana roots.	Nitrates	72-79	nitrate transporter 2:1	Arabidopsis thaliana	211-219
22432443-2	2012	Here, we have investigated interactions between the remaining AtNRT2 family members (AtNRT2.2 to AtNRT2.7) and AtNAR2.1, and their capacity for nitrate transport.	Nitrates	144-151	nitrate transporter 2.2	Arabidopsis thaliana	85-93
22432443-2	2012	Here, we have investigated interactions between the remaining AtNRT2 family members (AtNRT2.2 to AtNRT2.7) and AtNAR2.1, and their capacity for nitrate transport.	Nitrates	144-151	high affinity nitrate transporter 2.7	Arabidopsis thaliana	97-105
21786156-1	2012	Nitrate reductase is a key enzyme in the overall process of nitrate assimilation by plants.	Nitrates	60-67	nitrate reductase [NADH]-like	Cucumis sativus	0-17
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	35-42	regulatory particle triple-A ATPase 5A	Arabidopsis thaliana	111-116
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	35-42	Tubulin/FtsZ family protein	Arabidopsis thaliana	146-161
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	35-42	Tubulin/FtsZ family protein	Arabidopsis thaliana	163-167
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	regulatory particle triple-A ATPase 5A	Arabidopsis thaliana	111-116
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	Tubulin/FtsZ family protein	Arabidopsis thaliana	146-161
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	Tubulin/FtsZ family protein	Arabidopsis thaliana	163-167
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	regulatory particle triple-A ATPase 5A	Arabidopsis thaliana	111-116
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	Tubulin/FtsZ family protein	Arabidopsis thaliana	146-161
22329444-6	2012	Functional studies of the selected nitrate-responsive proteins indicate that the proteasome regulatory subunit RPT5a and the cytoskeleton protein Tubulin alpha-6 (TUA6) play important roles in plant nitrate responses by regulating plant N use efficiency (NUE) and low nitrate-induced anthocyanin biosynthesis, respectively.	Nitrates	199-206	Tubulin/FtsZ family protein	Arabidopsis thaliana	163-167
22809160-7	2012	Moreover, darkness induced significant elevation of the POX activity that was prevented by the addition of nitrate to the growth medium.	Nitrates	107-114	peroxidase-like	Triticum aestivum	56-59
22809160-8	2012	It is proposed that the changes in light conditions result in the competition between nitrate- and ROS-metabolizing activities of POX in leaves, and a possible interaction between NR and POX controls the levels of NO and ROS in the leaf tissue.	Nitrates	86-93	peroxidase-like	Triticum aestivum	130-133
22799190-3	2012	This system is useful for simultaneous separation and determination of ammonium ion (NH4+), nitrite ion (NO2(-)), and nitrate ion (NO3(-)) in water samples.	Nitrates	118-125	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
22192332-8	2012	RESULTS: High plasma levels of nitrite and nitrate (No2-/No3-) were observed in critically ill patients (mean level 78.92 mumol/l in sepsis and 97.20 mumol/l in septic shock).	Nitrates	43-50	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
22248361-5	2012	Series 1 consistently inhibited the secretion of MMP-9 from TNFalpha/IL1beta stimulated Caco-2 cells at 10 muM, which could be attributed to NO related effects because the non-nitrate panel did not affect enzyme levels.	Nitrates	176-183	matrix metallopeptidase 9	Homo sapiens	49-54
22263579-3	2012	In this study, we describe human and chicken sulfite oxidase variants in which the active site has been modified to alter substrate specificity and activity from sulfite oxidation to nitrate reduction.	Nitrates	183-190	sulfite oxidase	Gallus gallus	45-60
22246635-2	2012	This study shows that dissimilatory nitrate reduction to ammonium (DNRA) process, where nitrogen is not removed but instead recycled in the system, dominates nitrate reduction in low oxygen conditions (O(2) &lt;110 muM), which have been persistent in the central Gulf of Finland during the past decade.	Nitrates	36-43	latexin	Homo sapiens	215-218
22246635-2	2012	This study shows that dissimilatory nitrate reduction to ammonium (DNRA) process, where nitrogen is not removed but instead recycled in the system, dominates nitrate reduction in low oxygen conditions (O(2) &lt;110 muM), which have been persistent in the central Gulf of Finland during the past decade.	Nitrates	158-165	latexin	Homo sapiens	215-218
22434701-3	2012	The products of nitrite (NO(2) (-) ) oxidation by salivary peroxidase (SPO) and commercial bovine lactoperoxidase (LPO) are studied by utilizing an electrochemical assay that allows the direct, continuous monitoring of NO and/or NO(2) and by HPLC to assess nitrates at the end of the reaction.	Nitrates	257-265	lactoperoxidase	Homo sapiens	50-69
22434701-4	2012	Dialyzed saliva and LPO, in the presence of H(2) O(2) , convert nitrite into nitrate and form some NO, with a molar ratio of 10(3) .	Nitrates	77-84	lactoperoxidase	Bos taurus	20-23
22434701-8	2012	We conclude that SPO and LPO transform NO(2) (-) into nitrate-forming small amounts of NO in the presence of H(2) O(2) as an intermediate or a by-product, synthesized through the peroxynitrite pathway.	Nitrates	54-61	lactoperoxidase	Bos taurus	25-28
22219194-2	2012	In vitro studies reveal that MPO chlorinates and nitrates specific tyrosine residues of apoA-I, the major HDL protein.	Nitrates	49-57	apolipoprotein A1	Homo sapiens	88-94
22263579-0	2012	Structure-based alteration of substrate specificity and catalytic activity of sulfite oxidase from sulfite oxidation to nitrate reduction.	Nitrates	120-127	sulfite oxidase	Gallus gallus	78-93
22263579-8	2012	The nitrate reducing ability of the human sulfite oxidase triple mutant was nearly 3-fold greater than that of the double mutant.	Nitrates	4-11	sulfite oxidase	Homo sapiens	42-57
22154340-7	2012	The fastest nitrate reduction by GR-F with Pt was achieved at pH 9 among 7.5 to 11.	Nitrates	12-19	growth hormone releasing hormone	Homo sapiens	33-37
22178413-5	2012	We show that leukocyte emigration in response to the proinflammatory chemokine MIP-2 is reduced by 70% after 7 days of dietary nitrate supplementation as well as by acute intravenous nitrite administration.	Nitrates	127-134	C-X-C motif chemokine ligand 2	Rattus norvegicus	79-84
22178413-8	2012	In rats and mice subjected to a challenge with diclofenac, dietary nitrate prevented the increase in myeloperoxidase and P-selectin levels in small-intestinal tissue.	Nitrates	67-74	myeloperoxidase	Mus musculus	101-116
22178413-8	2012	In rats and mice subjected to a challenge with diclofenac, dietary nitrate prevented the increase in myeloperoxidase and P-selectin levels in small-intestinal tissue.	Nitrates	67-74	selectin, platelet	Mus musculus	121-131
22178413-9	2012	Antiseptic mouthwash, which eliminates oral nitrate reduction, markedly blunted the protective effect of dietary nitrate on P-selectin levels.	Nitrates	113-120	selectin P	Rattus norvegicus	124-134
22178413-11	2012	We conclude that dietary nitrate markedly reduces leukocyte recruitment to inflammation in a process involving attenuation of P-selectin and ICAM-1 upregulation.	Nitrates	25-32	selectin P	Rattus norvegicus	126-136
22178413-11	2012	We conclude that dietary nitrate markedly reduces leukocyte recruitment to inflammation in a process involving attenuation of P-selectin and ICAM-1 upregulation.	Nitrates	25-32	intercellular adhesion molecule 1	Rattus norvegicus	141-147
21904872-1	2012	Members of the peptide transporter/nitrate transporter 1 (PTR/NRT1) family in plants transport a variety of substrates like nitrate, di- and tripepetides, auxin and carboxylates.	Nitrates	35-42	nicotinamide riboside transporter	Saccharomyces cerevisiae S288C	62-66
27009655-4	2012	Urease and glutamine synthetase (GS) activities varied with nitrogen source in a manner consistent with regulation by cellular nitrogen status via NtcA (rather than by external availability of nitrogen) in all three strains and indicated that each strain experienced some degree of nitrogen insufficiency during growth on nitrate.	Nitrates	322-329	glutamate-ammonia ligase	Homo sapiens	33-35
22307851-6	2012	Accordingly, transcriptomic and enzymatic analyses revealed a higher expression of genes involved in nitrate assimilation when lst8-1 mutants were shifted to long days.	Nitrates	101-108	TOR complex subunit LST8	Saccharomyces cerevisiae S288C	127-131
22158677-0	2012	Regulation of high-affinity nitrate uptake in roots of Arabidopsis depends predominantly on posttranscriptional control of the NRT2.1/NAR2.1 transport system.	Nitrates	28-35	nitrate transporter 2:1	Arabidopsis thaliana	127-133
22158677-1	2012	In Arabidopsis (Arabidopsis thaliana), the NRT2.1 gene codes for the main component of the root nitrate (NO(3)(-)) high-affinity transport system (HATS).	Nitrates	96-103	nitrate transporter 2:1	Arabidopsis thaliana	43-49
22158760-2	2012	Nitrate Trasnporter2 (NRT2) gene family members are sentinels of nitrate availability.	Nitrates	0-7	nitrate transporter 2:1	Arabidopsis thaliana	22-26
22158760-2	2012	Nitrate Trasnporter2 (NRT2) gene family members are sentinels of nitrate availability.	Nitrates	65-72	nitrate transporter 2:1	Arabidopsis thaliana	22-26
22124705-1	2012	The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries.	Nitrates	77-84	monoamine oxidase A	Homo sapiens	163-168
22293356-0	2012	Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice.	Nitrates	37-44	interleukin 1 complex	Mus musculus	15-28
22124705-1	2012	The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric arteries.	Nitrates	77-84	amine oxidase copper containing 2	Homo sapiens	223-227
22170613-8	2012	The estimated LODs for nitrite and nitrate in ninefold diluted plasma sample were 0.05 and 0.07 muM, respectively.	Nitrates	35-42	latexin	Homo sapiens	96-99
22170613-9	2012	The LODs for nitrite and nitrate in original plasma samples were 0.45 and 0.63 muM.	Nitrates	25-32	latexin	Homo sapiens	79-82
22506100-0	2012	Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress.	Nitrates	103-110	heme oxygenase 1	Homo sapiens	0-16
22942686-1	2012	Glutamine synthetase (GS) is the key enzyme involved in the assimilation of ammonia derived either from nitrate reduction, N(2) fixation, photorespiration or asparagine breakdown.	Nitrates	104-111	glutamate-ammonia ligase	Homo sapiens	0-20
22506100-4	2012	We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects.	Nitrates	109-116	heme oxygenase 1	Homo sapiens	42-58
22506100-4	2012	We therefore speculated that induction of heme oxygenase-1 (HO-1) could be an efficient strategy to overcome nitrate tolerance and the associated side effects.	Nitrates	109-116	heme oxygenase 1	Homo sapiens	60-64
22506100-6	2012	Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1(+/-) mice.	Nitrates	33-40	heme oxygenase 1	Mus musculus	176-180
22506100-6	2012	Vice versa, pentaerithrityl tetranitrate (PETN), a nitrate that was previously reported to be devoid of adverse side effects, displayed tolerance and oxidative stress when the HO-1 pathway was blocked pharmacologically or genetically by using HO-1(+/-) mice.	Nitrates	33-40	heme oxygenase 1	Mus musculus	243-247
22506100-8	2012	With the present paper, we present and discuss our recent and previous findings on the role of HO-1 for the prevention of nitroglycerin-induced nitrate tolerance and for the beneficial effects of PETN therapy.	Nitrates	144-151	heme oxygenase 1	Homo sapiens	95-99
22227893-6	2012	In N-starved nrt2.4 mutants, nitrate uptake under low external supply and nitrate content in shoot phloem exudates was decreased.	Nitrates	29-36	nitrate transporter 2:1	Arabidopsis thaliana	13-17
22055212-6	2012	We suggest that high light-induced changes in plasma membrane H(+)ATPase activity and transcription might have an adaptive role in sustaining the higher request for the nitrate resulting from increased photosynthate availability.	Nitrates	169-176	membrane H(+)-ATPase 1	Zea mays	46-72
22227893-6	2012	In N-starved nrt2.4 mutants, nitrate uptake under low external supply and nitrate content in shoot phloem exudates was decreased.	Nitrates	74-81	nitrate transporter 2:1	Arabidopsis thaliana	13-17
22227893-7	2012	In the absence of NRT2.1 and NRT2.2, loss of function of NRT2.4 (triple mutants) has an impact on biomass production under low nitrate supply.	Nitrates	127-134	nitrate transporter 2.4	Arabidopsis thaliana	57-63
22880003-1	2012	The high affinity nitrate transport system in Arabidopsis thaliana involves one gene and potentially seven genes from the NRT1 and NRT2 family, respectively.	Nitrates	18-25	nitrate transporter 1.1	Arabidopsis thaliana	122-126
22880003-1	2012	The high affinity nitrate transport system in Arabidopsis thaliana involves one gene and potentially seven genes from the NRT1 and NRT2 family, respectively.	Nitrates	18-25	nitrate transporter 2:1	Arabidopsis thaliana	131-135
22880003-2	2012	Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes.	Nitrates	84-91	nitrate transporter 2:1	Arabidopsis thaliana	12-18
22880003-2	2012	Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes.	Nitrates	84-91	nitrate transporter 2:1	Arabidopsis thaliana	12-16
22880003-2	2012	Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes.	Nitrates	84-91	nitrate transporter 2:1	Arabidopsis thaliana	20-24
22880003-2	2012	Among them, NRT2.1, NRT2.2, NRT2.4 and NRT2.7 proteins have been shown to transport nitrate and are localized on the plasmalemma or the tonoplast membranes.	Nitrates	84-91	nitrate transporter 2:1	Arabidopsis thaliana	20-24
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	0-6
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	0-4
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	8-12
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	8-12
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	121-128	nitrate transporter 2:1	Arabidopsis thaliana	0-6
22880003-3	2012	NRT2.1, NRT2.2 and NRT2.4 play a role in nitrate uptake from soil solution by root cells while NRT2.7 is responsible for nitrate loading in the seed vacuole.	Nitrates	121-128	nitrate transporter 2:1	Arabidopsis thaliana	0-4
22678215-4	2012	The presence of 0.01 mmol L(-1) phosphate, 0.2 mmol L(-1) silicate, and 1 mmol L(-1) nitrate greatly reduced the efficiency of SAR, illustrating the vulnerability of this technology in diverse geochemical settings.	Nitrates	85-92	sarcosine dehydrogenase	Homo sapiens	127-130
22829864-0	2012	Role of endothelial AADC in cardiac synthesis of serotonin and nitrates accumulation.	Nitrates	63-71	dopa decarboxylase	Mus musculus	20-24
22808220-9	2012	We propose a mechanism in which leptin activates NOS III and induces NO that nitrates PEPCK-C to reduce its level and glyceroneogenesis, therefore limiting FA re-esterification in WAT.	Nitrates	77-85	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	86-93
22363694-4	2012	In marked contrast, the expressions of both mRNA and protein levels of inducible nitrate oxide synthase (iNOS) increased, and were accompanied by increased extracellular nitrate/nitrite production by Griess reaction.	Nitrates	81-88	nitric oxide synthase 2	Homo sapiens	105-109
21818694-0	2011	Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: substrate selectivity, enzyme inactivation, and active cysteine sites.	Nitrates	35-43	aldehyde dehydrogenase 2 family member	Homo sapiens	47-79
22439573-1	2011	The feasibility of hybrid systems for simultaneous removal of nitrate (NO3-) and ammonium ions (NH4+) from livestock wastewater was examined in batch experiments.	Nitrates	62-69	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
21986532-5	2011	eNOS activity was determined by nitrite/nitrate accumulation, either via a fluorometric assay or by(15)N-nitrite or estimated (15)N(3)-citrulline concentrations when (15)N(4)-ARG was used to challenge the cells.	Nitrates	40-47	nitric oxide synthase 3	Homo sapiens	0-4
21251210-9	2011	Three mitochondrial antioxidant enzymes were altered by DOX, i.e. up-regulation of manganese superoxide dismutase and peroxiredoxin 3 (Prx3), and down-regulation of Prx5, which were reversed by nitrate.	Nitrates	194-201	peroxiredoxin 3	Mus musculus	118-133
22320098-1	2011	A reusable catalytic reductor consisting of 96 copperized-cadmium pins attached to a microplate lid was developed to simultaneously reduce nitrate (NO3-) to nitrite (NO2-) in all wells of a standard microplate.	Nitrates	139-146	NBL1, DAN family BMP antagonist	Homo sapiens	148-151
21251210-9	2011	Three mitochondrial antioxidant enzymes were altered by DOX, i.e. up-regulation of manganese superoxide dismutase and peroxiredoxin 3 (Prx3), and down-regulation of Prx5, which were reversed by nitrate.	Nitrates	194-201	peroxiredoxin 3	Mus musculus	135-139
22187853-3	2011	A directly proportionate relationship was seen between methemoglobin level in the blood and nitrate ingestion.	Nitrates	92-99	hemoglobin subunit gamma 2	Homo sapiens	55-68
21862482-3	2011	Due to its localization exactly at the peak of this QTL, the putative NRT1-NO(3)(-) transporter (Medtr5g093170.1), closely related to Arabidopsis AtNRT1.3, a putative low-affinity nitrate transporter, appeared to be a significant candidate involved in the control of primary root growth and NO(3)(-) sensing.	Nitrates	180-187	nitrate transporter 1.1	Arabidopsis thaliana	70-74
21765367-1	2011	PURPOSE: Hemodynamic nitrate tolerance has been shown to result in an insulin-resistant state.	Nitrates	21-28	insulin	Oryctolagus cuniculus	70-77
21765367-3	2011	METHODS: Changes in insulin sensitivity in response to feeding in conscious rabbits were determined by rapid insulin sensitivity test, in both nitrate-tolerant and nitrate-intolerant animals.	Nitrates	143-150	insulin	Oryctolagus cuniculus	20-27
21765367-3	2011	METHODS: Changes in insulin sensitivity in response to feeding in conscious rabbits were determined by rapid insulin sensitivity test, in both nitrate-tolerant and nitrate-intolerant animals.	Nitrates	164-171	insulin	Oryctolagus cuniculus	20-27
21765367-8	2011	CONCLUSIONS: Nitrate tolerance blocks both the meal-induced insulin sensitization phenomenon and the insulin-sensitizing effect of intraportal CCK.	Nitrates	13-20	insulin	Oryctolagus cuniculus	60-67
21765367-8	2011	CONCLUSIONS: Nitrate tolerance blocks both the meal-induced insulin sensitization phenomenon and the insulin-sensitizing effect of intraportal CCK.	Nitrates	13-20	cholecystokinin	Oryctolagus cuniculus	143-146
21949212-0	2011	Dissecting the role of CHITINASE-LIKE1 in nitrate-dependent changes in root architecture.	Nitrates	42-49	Chitinase family protein	Arabidopsis thaliana	23-38
21914816-6	2011	In ineffective nodules and in nodules fed with nitrate, two conditions in which nitrogen fixation is impaired and GS activity is reduced, a significant increase in nodule GS nitration levels was observed.	Nitrates	47-54	LOC11405318	Medicago truncatula	114-116
21949212-1	2011	The root phenotype of an Arabidopsis (Arabidopsis thaliana) mutant of CHITINASE-LIKE1 (CTL1), called arm (for anion-related root morphology), was previously shown to be conditional on growth on high nitrate, chloride, or sucrose.	Nitrates	199-206	Chitinase family protein	Arabidopsis thaliana	70-85
21949212-1	2011	The root phenotype of an Arabidopsis (Arabidopsis thaliana) mutant of CHITINASE-LIKE1 (CTL1), called arm (for anion-related root morphology), was previously shown to be conditional on growth on high nitrate, chloride, or sucrose.	Nitrates	199-206	Chitinase family protein	Arabidopsis thaliana	87-91
21949212-10	2011	Interestingly, eto2 and eto3 ethylene overproduction mutants mimicked some of the conditional root characteristics of the arm mutant on high nitrate.	Nitrates	141-148	ACC synthase 5	Arabidopsis thaliana	15-19
21949212-10	2011	Interestingly, eto2 and eto3 ethylene overproduction mutants mimicked some of the conditional root characteristics of the arm mutant on high nitrate.	Nitrates	141-148	1-aminocyclopropane-1-carboxylate synthase 9	Arabidopsis thaliana	24-28
21844097-2	2011	Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1 (HO-1).	Nitrates	21-28	heme oxygenase 1	Homo sapiens	110-126
21907028-4	2011	The nitrate system featured a limit of detection of 0.04 mg N L(-1), 0.4%RSD (1 mg N L(-1) as nitrate, n=10), a coefficient of determination (R(2)) of 0.9995 over the calibration range 0.0-2.0 mg N L(-1), and a data acquisition time of 1.5s per spectrum.	Nitrates	4-11	nuclear receptor subfamily 4 group A member 1	Homo sapiens	103-107
22073628-2	2011	Nitrate (NO3-) is the form of reactive N that is most susceptible to leaching and runoff; thus, a more thorough understanding of nitrification and NO3(-) availability is needed if we are to accurately predict the consequences of residential expansion for water quality.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
22073628-2	2011	Nitrate (NO3-) is the form of reactive N that is most susceptible to leaching and runoff; thus, a more thorough understanding of nitrification and NO3(-) availability is needed if we are to accurately predict the consequences of residential expansion for water quality.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
21844097-2	2011	Pentaerithrityl tetranitrate (PETN) is an organic nitrate with potent antioxidant properties via induction of heme oxygenase-1 (HO-1).	Nitrates	21-28	heme oxygenase 1	Homo sapiens	128-132
21915898-6	2011	The deshieldings on H-3a, H-5a and the ortho protons of the phenyl groups are less in the nitrate and picrate than in the corresponding hydrochloride.	Nitrates	90-97	H3 clustered histone 1	Homo sapiens	20-24
21407132-8	2011	Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031).	Nitrates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
21407132-8	2011	Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031).	Nitrates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	115-121
21407132-8	2011	Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031).	Nitrates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	115-121
21407132-8	2011	Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031).	Nitrates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	115-121
21407132-8	2011	Nitrate supplementation significantly reduced VO(2peak)(nitrate = 4.64 +- 0.35 L min(-1), placebo = 4.82 +- 0.33 L min(-1), P = 0.010) and the ratio between VO(2) and power at maximal intensity (nitrate = 11.2 +- 1.1 mL min(-1) W(-1), placebo = 11.8 +- 1.1 mL min(-1) W(-1), P = 0.031).	Nitrates	56-63	CD59 molecule (CD59 blood group)	Homo sapiens	81-87
21915898-8	2011	These observations suggest that the nitrates and pictrate exist as ion pairs in DMSO-d(6) and the nitrate and picrate ions shield, H-3a, H-5a and the ortho protons by magnetic anistropic effect.	Nitrates	36-44	H3 clustered histone 1	Homo sapiens	131-135
21915898-8	2011	These observations suggest that the nitrates and pictrate exist as ion pairs in DMSO-d(6) and the nitrate and picrate ions shield, H-3a, H-5a and the ortho protons by magnetic anistropic effect.	Nitrates	36-43	H3 clustered histone 1	Homo sapiens	131-135
21762167-7	2011	Our findings, in addition to strengthening already known mechanisms, revealed the existence of a new complex signaling framework in which brassinosteroids (BRI1), the module MKK2-MAPK6 and the fine regulation of nitric oxide homeostasis via the co-expression of synthetic (nitrate reductase) and scavenging (hemoglobin) components may play key functions in maize responses to nitrate.	Nitrates	273-280	non-symbiotic hemoglobin	Zea mays	308-318
21984695-4	2011	Separable fragments of RIN4, including those produced when the T3E AvrRpt2 cleaves RIN4 and each containing a plant-specific nitrate-induced (NOI) domain, suppress PTI.	Nitrates	125-132	RPM1 interacting protein 4	Arabidopsis thaliana	23-27
21506955-1	2011	BACKGROUND AND PURPOSE: Recent studies have suggested an essential role for aldehyde dehydrogenase 2 (ALDH2) in the bioactivation of organic nitrates such as glyceryl trinitrate (GTN).	Nitrates	141-149	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	76-100
21327803-11	2011	RDX biodegradation activity by the T7 isolate was inhibited in the presence of nitrate or ammonium concentrations above 1.6 and 5.5 mM, respectively (100 mg l(-1)) while the T9N isolate"s activity was retarded only by ammonium concentrations above 5.5 mM.	Nitrates	79-86	radixin	Homo sapiens	0-3
21327803-13	2011	RDX-degrading activity by the Rhodococcus species isolate T9N may have important implications for the bioremediation of nitrate-rich RDX-contaminated aquifers.	Nitrates	120-127	radixin	Homo sapiens	0-3
21327803-13	2011	RDX-degrading activity by the Rhodococcus species isolate T9N may have important implications for the bioremediation of nitrate-rich RDX-contaminated aquifers.	Nitrates	120-127	radixin	Homo sapiens	133-136
21506955-1	2011	BACKGROUND AND PURPOSE: Recent studies have suggested an essential role for aldehyde dehydrogenase 2 (ALDH2) in the bioactivation of organic nitrates such as glyceryl trinitrate (GTN).	Nitrates	141-149	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	102-107
21728895-15	2011	Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate.	Nitrates	70-77	nuclear RNA export factor 1	Homo sapiens	95-98
21642046-7	2011	RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002).	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
21642046-7	2011	RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002).	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
21642046-7	2011	RESULTS: Percent Latino was associated with a 0.04-mg nitrate-ion (NO3)/L increase in a CWS"s estimated NO3 concentration [95% confidence interval (CI), -0.08 to 0.16], and rate of home ownership was associated with a 0.16-mg NO3/L decrease (95% CI, -0.32 to 0.002).	Nitrates	54-61	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
21728895-15	2011	Scenario analyses with a higher consumption of vegetables or a higher nitrate concentration in tap water showed a significant higher intake of nitrate.	Nitrates	143-150	nuclear RNA export factor 1	Homo sapiens	95-98
21543107-1	2011	INTRODUCTION: Despite experimental evidences of the influence of the aging suppressor gene Klotho, on the modulation of endothelial nitric oxide synthase (eNOS) activity and nitric oxide (NO) production, the contribution of its variants to the phenotypic variance of plasma nitrite and nitrate (NO(x)) has not been addressed to date.	Nitrates	286-293	klotho	Homo sapiens	91-97
21777567-2	2011	The genes for nitrate reductase (NR) and nitrite reductase (NIR), which are enzymes in the nitrate assimilation pathway, are typical nitrate-inducible genes.	Nitrates	14-21	nitrite reductase 1	Arabidopsis thaliana	60-63
21777567-2	2011	The genes for nitrate reductase (NR) and nitrite reductase (NIR), which are enzymes in the nitrate assimilation pathway, are typical nitrate-inducible genes.	Nitrates	91-98	nitrite reductase 1	Arabidopsis thaliana	60-63
21777567-3	2011	We previously identified the first authentic nitrate-responsive cis-element (NRE) for nitrate-inducible transcription by the analysis of the NIR gene promoter from Arabidopsis.	Nitrates	45-52	nitrite reductase 1	Arabidopsis thaliana	141-144
21777567-3	2011	We previously identified the first authentic nitrate-responsive cis-element (NRE) for nitrate-inducible transcription by the analysis of the NIR gene promoter from Arabidopsis.	Nitrates	86-93	nitrite reductase 1	Arabidopsis thaliana	141-144
21777567-6	2011	Second, we show that NRE-like sequences are present in various dicotyledonous and monocotyledonous NIR gene promoters at similar positions and that they also drive nitrate-inducible expression in Arabidopsis.	Nitrates	164-171	nitrite reductase 1	Arabidopsis thaliana	99-102
21708390-4	2011	Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively.	Nitrates	83-90	latexin	Homo sapiens	129-132
21652715-1	2011	Ynt1, the single high affinity nitrate and nitrite transporter of the yeast Hansenula polymorpha, is regulated by the quality of nitrogen sources.	Nitrates	31-38	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	0-4
21652715-6	2011	As a result, in this strain Ynt1 is sorted to the vacuole, from both plasma membrane and the later biosynthetic pathway in nitrogen-free conditions and nitrate.	Nitrates	152-159	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	28-32
21554376-9	2011	Levels of nitrite and nitrate (NO(x)), as an index of nitric oxide, bioavailability were significantly decreased in the iNOS(-/-) diabetic mouse heart.	Nitrates	22-29	nitric oxide synthase 2, inducible	Mus musculus	120-124
21708390-4	2011	Phosphate levels were abnormally high varying between 4.35 and 130.82 muM, whereas nitrate and nitrite ranged from 0.06 to 54.05 muM and from 0.28 to 19.23 muM, respectively.	Nitrates	83-90	latexin	Homo sapiens	129-132
21486304-3	2011	A two-component system for nitrate transport including NRT2s with a partner protein (NAR2 or NRT3.1) has been identified in Arabidopsis.	Nitrates	27-34	nitrate transporter 2:1	Arabidopsis thaliana	55-59
21486304-3	2011	A two-component system for nitrate transport including NRT2s with a partner protein (NAR2 or NRT3.1) has been identified in Arabidopsis.	Nitrates	27-34	nitrate transmembrane transporter	Arabidopsis thaliana	93-99
22097361-4	2011	Ammonium nitrogen deposition had larger effects on soil NH4+ -N content, nitrate nitrogen deposition had larger effects on soil NO3- -N content, while mixed ammonium and nitrate nitrogen deposition increased the contents of both soil NH4+ -N and soil NO3- -N, and the increments were higher than those of ammonium nitrogen deposition and nitrate nitrogen deposition, suggesting the additive effects of the mixed ammonium and nitrate nitrogen deposition on the forest soil available N.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
21696799-1	2011	Denitrifying woodchip bioreactors (denitrification beds) are increasingly used to remove excess nitrate (NO3-) from point-sources such as wastewater effluent or subsurface drains from agricultural fields.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
22097361-4	2011	Ammonium nitrogen deposition had larger effects on soil NH4+ -N content, nitrate nitrogen deposition had larger effects on soil NO3- -N content, while mixed ammonium and nitrate nitrogen deposition increased the contents of both soil NH4+ -N and soil NO3- -N, and the increments were higher than those of ammonium nitrogen deposition and nitrate nitrogen deposition, suggesting the additive effects of the mixed ammonium and nitrate nitrogen deposition on the forest soil available N.	Nitrates	170-177	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
21772271-5	2011	Decreased nitrate reductase activity in siz1-2 plants resulted in low nitrogen concentrations, low nitric oxide production and high nitrate content in comparison with wild-type plants.	Nitrates	10-17	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	40-44
21754669-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))(2)](n), the Co(II) ion is located on an inversion center and is six-coordinated in an octa-hedral environment defined by four N atoms of the pyridine rings and two O atoms of the nitrate anions.	Nitrates	236-243	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-75
21762512-10	2011	Addition of TN-C induced IL-6, PGE2, and nitrate release and upregulated ADAMTS4 mRNA in cultured primary human and bovine chondrocytes.	Nitrates	41-48	tenascin C	Homo sapiens	12-16
21424691-5	2011	Genetic and biochemical analyses identified the essential nitrate/nitrite assimilation functions of the encoded proteins, orderly, the assimilatory nitrate reductase catalytic subunit (NasA), nitrate reductase electron transfer subunit (NasC), nitrate/nitrite transporter (NasK), assimilatory nitrite reductase large subunit (NasB) and small subunit (NasD), bifunctional uroporphyrinogen-III synthase (NasE), and an unknown function protein (NasF).	Nitrates	58-65	uroporphyrinogen-III synthase	Amycolatopsis mediterranei U32	371-400
21446951-1	2011	The large sulfur bacteria, Beggiatoa spp., live on the oxidation of sulfide with oxygen or nitrate, but avoid high concentrations of both sulfide and oxygen.	Nitrates	91-98	histocompatibility minor 13	Homo sapiens	37-40
21228891-9	2011	Our results suggest that the AOA, not the AOB, were contributing to nitrate leaching at the site by providing substrate for the nitrite oxidizers.	Nitrates	68-75	aprataxin	Homo sapiens	29-32
21334141-7	2011	BBS-2 significantly reduced the increases in lung lymph nitrite/nitrate (10 +- 3 muM vs. 26 +- 6 muM in controls, p &lt; 0.05) and 3-nitrotyrosine (109 +- 11 (densitometry value) vs. 151 +- 18 in controls, p &lt; 0.05).	Nitrates	64-71	Bardet-Biedl syndrome 2 protein	Ovis aries	0-5
21657847-1	2011	AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated.	Nitrates	199-206	myeloperoxidase	Homo sapiens	40-55
21657847-1	2011	AIMS: Elevation of the leukocyte enzyme myeloperoxidase (MPO) in stable coronary artery disease (CAD) is controversial and its relationship with oxidized low-density lipoprotein (ox-LDL) and nitrite/nitrate (NOx) levels in CAD patients has not been evaluated.	Nitrates	199-206	myeloperoxidase	Homo sapiens	57-60
21421215-8	2011	Coexisting anions such as sulfate, nitrate, chloride, carbonate, and humic acid could decrease the sensitivity of the SERS analysis.	Nitrates	35-42	seryl-tRNA synthetase 1	Homo sapiens	118-122
21593598-2	2011	In a recent work, we have revealed MPK6 could phosphorylate Arabidopsis NIA2 at the serine 627 in hinge 2 region, this phosporylation may represent a rapid activation mechnism when plant need excessive nitrate reduction.	Nitrates	202-209	MAP kinase 6	Arabidopsis thaliana	35-39
21593598-2	2011	In a recent work, we have revealed MPK6 could phosphorylate Arabidopsis NIA2 at the serine 627 in hinge 2 region, this phosporylation may represent a rapid activation mechnism when plant need excessive nitrate reduction.	Nitrates	202-209	nitrate reductase 2	Arabidopsis thaliana	72-76
21586729-4	2011	SLAH3 (SLAC1 homolog 3) was also present in guard cells, and coexpression of SLAH3 with the calcium ion (Ca2+)-dependent kinase CPK21 in Xenopus oocytes mediated nitrate-induced anion currents.	Nitrates	162-169	C4-dicarboxylate transporter/malic acid transport protein	Arabidopsis thaliana	7-12
21754318-1	2011	In the title compound, [Co(NO(3))(2)(C(18)H(16)N(2)O(2))], the Co(II) ion is six-coordinated in a distorted octa-hedral environment defined by two O and two N atoms from the ligand and by two O atoms from two nitrate anions.	Nitrates	209-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	63-69
20559710-8	2011	High nitrate levels may have already affected public health based on limited sampling for methemoglobin.	Nitrates	5-12	hemoglobin subunit gamma 2	Homo sapiens	90-103
20518849-7	2011	Intact MLC1 levels, measured by 2D gel electrophoresis and immunoblot, were shown to decrease with increasing duration of ischemia, which correlated with increasing levels of nitrotyrosine and nitrite/nitrate.	Nitrates	201-208	myosin light chain 1	Homo sapiens	7-11
21480587-4	2011	delta15N(NO3) and delta18O(NO3) of catchment surface water and groundwater samples revealed a dominant influence from microbially cycled and nitrified source-nitrogen, which results in high nitrate concentrations in Chalk groundwater and upstream in the River Wensum.	Nitrates	190-197	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
21448006-1	2011	NRT1.1 is a dual-affinity nitrate transporter and a nitrate sensor that plays a role in nitrate-dependent signaling pathway.	Nitrates	26-33	immunoglobulin superfamily member 9	Homo sapiens	0-4
21052766-0	2011	Evidence for a nitrate-independent function of the nitrate sensor NRT1.1 in Arabidopsis thaliana.	Nitrates	15-22	nitrate transporter 1.1	Arabidopsis thaliana	66-72
21052766-0	2011	Evidence for a nitrate-independent function of the nitrate sensor NRT1.1 in Arabidopsis thaliana.	Nitrates	51-58	nitrate transporter 1.1	Arabidopsis thaliana	66-72
21052766-1	2011	NRT1.1 is a putative nitrate sensor and is involved in many nitrate-dependent responses.	Nitrates	21-28	nitrate transporter 1.1	Arabidopsis thaliana	0-6
21052766-1	2011	NRT1.1 is a putative nitrate sensor and is involved in many nitrate-dependent responses.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	0-6
21052766-2	2011	On the other hand, a nitrate-independent function of NRT1.1 has been implied, but the clear-cut evidence is unknown.	Nitrates	21-28	nitrate transporter 1.1	Arabidopsis thaliana	53-59
21052766-4	2011	This unique phenotype was not observed in mutants of NLP7, which has been suggested to play a role in the nitrate-dependent signaling pathway.	Nitrates	106-113	NIN like protein 7	Arabidopsis thaliana	53-57
21052766-5	2011	Our real-time PCR analysis, and evidence from a literature survey revealed that several genes relevant to the aliphatic glucosinolate-biosynthetic pathway were regulated via a nitrate-independent signal from NRT1.1.	Nitrates	176-183	nitrate transporter 1.1	Arabidopsis thaliana	208-214
21052766-6	2011	When taken together, the present study strongly suggests the existence of a nitrate-independent function of NRT1.1.	Nitrates	76-83	nitrate transporter 1.1	Arabidopsis thaliana	108-114
21448006-1	2011	NRT1.1 is a dual-affinity nitrate transporter and a nitrate sensor that plays a role in nitrate-dependent signaling pathway.	Nitrates	52-59	immunoglobulin superfamily member 9	Homo sapiens	0-4
21448006-2	2011	Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1.	Nitrates	130-137	immunoglobulin superfamily member 9	Homo sapiens	36-40
21571952-0	2011	Arabidopsis nitrate transporter NRT1.9 is important in phloem nitrate transport.	Nitrates	12-19	nitrate transporter 1.1	Arabidopsis thaliana	32-36
21571952-1	2011	This study of the Arabidopsis thaliana nitrate transporter NRT1.9 reveals an important function for a NRT1 family member in phloem nitrate transport.	Nitrates	39-46	nitrate transporter 1.1	Arabidopsis thaliana	59-63
21448006-2	2011	Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1.	Nitrates	157-164	immunoglobulin superfamily member 9	Homo sapiens	36-40
21571952-1	2011	This study of the Arabidopsis thaliana nitrate transporter NRT1.9 reveals an important function for a NRT1 family member in phloem nitrate transport.	Nitrates	39-46	nitrate transporter 1.1	Arabidopsis thaliana	102-106
21448006-2	2011	Recently, it has been revealed that NRT1.1 mutants show enhanced tolerance to ammonium and/or low pH conditions in the absence of nitrate, which indicates a nitrate-independent function of NRT1.1.	Nitrates	157-164	immunoglobulin superfamily member 9	Homo sapiens	189-193
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	19-26	nitrate transporter 1.1	Arabidopsis thaliana	3-7
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	19-26	nitrate transporter 1.1	Arabidopsis thaliana	134-138
21448006-3	2011	Detailed underlying mechanisms for the ammonium/low pH-tolerance of the NRT1.1 mutants will be revealed by paying attention to auxin behavior, phosphorylated status of NRT1.1 and other components related to the primary nitrate response and nitrate transport.	Nitrates	219-226	immunoglobulin superfamily member 9	Homo sapiens	72-76
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	3-7
21448006-3	2011	Detailed underlying mechanisms for the ammonium/low pH-tolerance of the NRT1.1 mutants will be revealed by paying attention to auxin behavior, phosphorylated status of NRT1.1 and other components related to the primary nitrate response and nitrate transport.	Nitrates	240-247	immunoglobulin superfamily member 9	Homo sapiens	72-76
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	134-138
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	3-7
21454300-0	2011	The regulatory region controlling the nitrate-responsive expression of a nitrate reductase gene, NIA1, in Arabidopsis.	Nitrates	38-45	nitrate reductase 1	Arabidopsis thaliana	73-90
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	134-138
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	3-7
21571952-4	2011	In nrt1.9 mutants, nitrate content in root phloem exudates was decreased, and downward nitrate transport was reduced, suggesting that NRT1.9 may facilitate loading of nitrate into the root phloem and enhance downward nitrate transport in roots.	Nitrates	87-94	nitrate transporter 1.1	Arabidopsis thaliana	134-138
21571952-5	2011	Under high nitrate conditions, the nrt1.9 mutant showed enhanced root-to-shoot nitrate transport and plant growth.	Nitrates	11-18	nitrate transporter 1.1	Arabidopsis thaliana	35-39
21571952-5	2011	Under high nitrate conditions, the nrt1.9 mutant showed enhanced root-to-shoot nitrate transport and plant growth.	Nitrates	79-86	nitrate transporter 1.1	Arabidopsis thaliana	35-39
21571952-6	2011	We conclude that phloem nitrate transport is facilitated by expression of NRT1.9 in root companion cells.	Nitrates	24-31	Major facilitator superfamily protein	Arabidopsis thaliana	74-80
21571952-7	2011	In addition, enhanced root-to-shoot xylem transport of nitrate in nrt1.9 mutants points to a negative correlation between xylem and phloem nitrate transport.	Nitrates	55-62	nitrate transporter 1.1	Arabidopsis thaliana	66-70
21571952-7	2011	In addition, enhanced root-to-shoot xylem transport of nitrate in nrt1.9 mutants points to a negative correlation between xylem and phloem nitrate transport.	Nitrates	139-146	nitrate transporter 1.1	Arabidopsis thaliana	66-70
21454300-0	2011	The regulatory region controlling the nitrate-responsive expression of a nitrate reductase gene, NIA1, in Arabidopsis.	Nitrates	38-45	nitrate reductase 1	Arabidopsis thaliana	97-101
21454300-1	2011	Nitrate reductase (NR) is the enzyme that catalyzes the first step of nitrate assimilation.	Nitrates	70-77	nitrate reductase 1	Arabidopsis thaliana	0-17
21454300-1	2011	Nitrate reductase (NR) is the enzyme that catalyzes the first step of nitrate assimilation.	Nitrates	70-77	nitrate reductase 1	Arabidopsis thaliana	19-21
21454300-2	2011	It is well known that the expression of NR genes is rapidly induced in various plants by nitrate.	Nitrates	89-96	nitrate reductase 1	Arabidopsis thaliana	40-42
21454300-4	2011	This cast some doubt on the role of the NR gene promoter in the nitrate-inducible expression of this gene.	Nitrates	64-71	nitrate reductase 1	Arabidopsis thaliana	40-42
21454300-9	2011	We also show that the 2.7 kb promoter sequence of NIA2, another NR gene of Arabidopsis, cannot direct nitrate-inducible expression.	Nitrates	102-109	nitrate reductase 2	Arabidopsis thaliana	50-54
21239382-4	2011	In Arabidopsis, increasing evidence suggests that, for nitrate, the main nitrogen source for most plant species, a major sensor is the NRT1.1 nitrate transporter, also contributing to nitrate uptake by the roots.	Nitrates	55-62	nicotinamide riboside transporter	Saccharomyces cerevisiae S288C	135-139
21584187-3	2011	Ferredoxin-nitrite reductase (NiR) catalyses the reduction of nitrite to ammonium in the second step of the nitrate- assimilation pathway.	Nitrates	108-115	nitrite reductase 1	Arabidopsis thaliana	0-28
21584187-3	2011	Ferredoxin-nitrite reductase (NiR) catalyses the reduction of nitrite to ammonium in the second step of the nitrate- assimilation pathway.	Nitrates	108-115	nitrite reductase 1	Arabidopsis thaliana	30-33
21239382-4	2011	In Arabidopsis, increasing evidence suggests that, for nitrate, the main nitrogen source for most plant species, a major sensor is the NRT1.1 nitrate transporter, also contributing to nitrate uptake by the roots.	Nitrates	142-149	nicotinamide riboside transporter	Saccharomyces cerevisiae S288C	135-139
21239382-7	2011	The various facets, as well as the mechanisms of nitrate sensing by NRT1.1 are considered, and the possible occurrence of other nitrate transceptors is discussed.	Nitrates	49-56	nicotinamide riboside transporter	Saccharomyces cerevisiae S288C	68-72
21450100-9	2011	CSF Nitrate levels were detected using the Griess reagent.	Nitrates	4-11	colony stimulating factor 2	Homo sapiens	0-3
21470979-1	2011	Various human-induced changes to the atmosphere have caused carbon dioxide (CO2), nitrogen dioxide (NO2) and nitrate deposition (NO3-) to increase in many regions of the world.	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
21252222-3	2011	Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance.	Nitrates	70-78	aldehyde dehydrogenase 2 family member	Homo sapiens	145-151
21450087-3	2011	RESULTS: The expression of the nap genes, nrfA, cymA and hcp was significantly reduced in etrA deletion mutant EtrA7-1; however, limited anaerobic growth and nitrate reduction occurred, suggesting that multiple regulators control nitrate reduction in this strain.	Nitrates	230-237	hydroxylamine reductase	Shewanella oneidensis MR-1	57-60
21252222-3	2011	Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance.	Nitrates	70-77	aldehyde dehydrogenase 2 family member	Homo sapiens	145-151
21252222-3	2011	Therefore, we here compared effects of various electrophiles (organic nitrates, reactive fatty acid metabolites, or oxidants) on the activity of ALDH-2 with special emphasis on organic nitrate-induced inactivation of the enzyme, the biochemical correlate of nitrate tolerance.	Nitrates	185-192	aldehyde dehydrogenase 2 family member	Homo sapiens	145-151
21156214-2	2011	A possible mechanism may involve nitrate-mediated activation of various extracellular matrix (ECM) proteases, particularly matrix metalloproteinase-9 (MMP-9), and adhesion molecules in human macrophages, leading to the destabilization of atherosclerotic plaques.	Nitrates	33-40	matrix metallopeptidase 9	Homo sapiens	123-149
21156214-2	2011	A possible mechanism may involve nitrate-mediated activation of various extracellular matrix (ECM) proteases, particularly matrix metalloproteinase-9 (MMP-9), and adhesion molecules in human macrophages, leading to the destabilization of atherosclerotic plaques.	Nitrates	33-40	matrix metallopeptidase 9	Homo sapiens	151-156
21193589-5	2011	The expression of inducible nitric oxide (NO) synthase (iNOS) mRNA was increased in the vascular tissues isolated from BDL rats, and accordingly, nitrate/nitrite production was increased.	Nitrates	146-153	nitric oxide synthase 2	Rattus norvegicus	56-60
21520758-6	2011	Low nitrate (NO3-) concentrations (0.2-0.4 mg NO3- -NL(-1)) in the shallow groundwater of the cropping system were associated with low rates of mineralization and nitrification (33 kg N ha(-1) yr(-1)) and high grass seed crop uptake of N (155 kg N ha(-1) yr(-1)).	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
21445844-8	2011	During oxygenation of nitric oxide to nitrate, oxidized ferric hemoglobin is formed (methemoglobin), which can be reduced by an associated reductase.	Nitrates	38-45	hemoglobin subunit gamma 2	Homo sapiens	85-98
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Nitrates	126-133	interleukin 2	Mus musculus	89-93
21304405-7	2011	In conjunction with IL-2 treatment, oral curcumin administration significantly inhibited IL-2 therapy-induced urinary nitrite/nitrate excretion and iNOS expression of tumor tissues, and further increased the IL-2 therapy-induced prolongation of survival in a murine Meth-A ascites tumor model.	Nitrates	126-133	interleukin 2	Mus musculus	89-93
21520758-6	2011	Low nitrate (NO3-) concentrations (0.2-0.4 mg NO3- -NL(-1)) in the shallow groundwater of the cropping system were associated with low rates of mineralization and nitrification (33 kg N ha(-1) yr(-1)) and high grass seed crop uptake of N (155 kg N ha(-1) yr(-1)).	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
20938379-12	2011	Significant decreases in plasma nitrate/nitrite after injury were associated with increased lung ADMA concentrations and decreased DDAH-2 expression.	Nitrates	32-39	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	131-137
21329998-11	2011	In addition, genes involved in nitrate dissimilation (nre, nar, nir), catalase (kat), or superoxide dismutase (sod) were well detected.	Nitrates	31-38	superoxide dismutase	Staphylococcus equorum	89-109
21455488-0	2011	Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in arabidopsis.	Nitrates	58-65	SPX (SYG1/Pho81/XPR1) domain-containing protein	Arabidopsis thaliana	22-25
21455488-10	2011	Also the Pi overaccumulator pho2 mutant shows Pi toxicity in a nitrate-dependent manner similar to the nla mutant.	Nitrates	63-70	phosphate 2	Arabidopsis thaliana	28-32
21455488-12	2011	The results demonstrate that NLA and miR827 have pivotal roles in regulating Pi homeostasis in plants in a nitrate-dependent fashion.	Nitrates	107-114	SPX (SYG1/Pho81/XPR1) domain-containing protein	Arabidopsis thaliana	29-32
21455488-12	2011	The results demonstrate that NLA and miR827 have pivotal roles in regulating Pi homeostasis in plants in a nitrate-dependent fashion.	Nitrates	107-114	MIR827	Arabidopsis thaliana	37-43
20300837-0	2011	Nitrate levels modulate denitrification activity in tropical mangrove sediments (Goa, India).	Nitrates	0-7	tripartite motif containing 47	Homo sapiens	81-84
20237835-6	2011	Nitrate (as NO3-) contamination has appeared as another anthropogenic threat to some intensively cultivable rural habitations of this region.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	12-15
21036778-8	2011	The use of BNP levels, in conjunction with other clinical information, significantly increased the detection of HF in combination with an additional diagnosis (32 vs. 16%, P = 0.001) and also increased the application of HF-specific medical therapy (nitrates: 32 vs. 23%, P &lt; 0.05 and diuretics: 65 vs. 50%, P &lt; 0.01).	Nitrates	250-258	natriuretic peptide B	Homo sapiens	11-14
20959627-0	2011	The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting.	Nitrates	140-147	hypothetical protein	Arabidopsis thaliana	14-34
20959627-0	2011	The cytosolic glutamine synthetase GLN1;2 plays a role in the control of plant growth and ammonium homeostasis in Arabidopsis rosettes when nitrate supply is not limiting.	Nitrates	140-147	hypothetical protein	Arabidopsis thaliana	35-41
20959627-11	2011	Altogether the results suggest that GLN1;2 is essential for nitrogen assimilation under ample nitrate supply and for ammonium detoxification.	Nitrates	94-101	hypothetical protein	Arabidopsis thaliana	36-42
20959627-3	2011	GLN1;2 is the most highly expressed in leaves and is over-expressed in roots by ammonium supply and in rosettes by ample nitrate supply compared with limiting nitrate supply.	Nitrates	121-128	hypothetical protein	Arabidopsis thaliana	0-6
20959627-3	2011	GLN1;2 is the most highly expressed in leaves and is over-expressed in roots by ammonium supply and in rosettes by ample nitrate supply compared with limiting nitrate supply.	Nitrates	159-166	hypothetical protein	Arabidopsis thaliana	0-6
20959627-10	2011	Growing plants in vitro with ammonium or nitrate as the sole nitrogen source allowed us to confirm that GLN1;2 is induced by ammonium in roots and to observe that gln1;2 mutants displayed, under such conditions, longer root hair and smaller rosette phenotypes in ammonium.	Nitrates	41-48	hypothetical protein	Arabidopsis thaliana	104-110
20959627-10	2011	Growing plants in vitro with ammonium or nitrate as the sole nitrogen source allowed us to confirm that GLN1;2 is induced by ammonium in roots and to observe that gln1;2 mutants displayed, under such conditions, longer root hair and smaller rosette phenotypes in ammonium.	Nitrates	41-48	hypothetical protein	Arabidopsis thaliana	163-169
21112616-8	2011	For the Salburua wetland riparian soil, we estimated a potential nitrate removal capacity of 1012 kg N-NO3-ha-1 year-1, and potential greenhouse gas emissions of 5620 kg CO2 ha-1 year-1 and 240 kg N-N2O ha-1 year-1.	Nitrates	65-72	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
21193579-3	2011	Nitrate transporters (NRT) from the NRT1 and NRT2 families ensure the capacity of root cells to take up nitrate, through high- and low-affinity systems (HATS and LATS) depending on nitrate concentrations in the soil solution.	Nitrates	104-111	immunoglobulin superfamily member 9	Homo sapiens	36-40
21193579-3	2011	Nitrate transporters (NRT) from the NRT1 and NRT2 families ensure the capacity of root cells to take up nitrate, through high- and low-affinity systems (HATS and LATS) depending on nitrate concentrations in the soil solution.	Nitrates	181-188	immunoglobulin superfamily member 9	Homo sapiens	36-40
21193579-4	2011	Other members of the NRT1 family are involved subsequently in loading and unloading of nitrate to and from the xylem vessels, allowing its distribution to aerial organs or its remobilization from old leaves.	Nitrates	87-94	immunoglobulin superfamily member 9	Homo sapiens	21-25
21132432-7	2011	Second, gene expression of AOX is suppressed when N is predominately available as nitrate instead of ammonium.	Nitrates	82-89	acyl-CoA oxidase 1	Homo sapiens	27-30
21184738-8	2011	While nNOS inhibition at 4h was associated with a trend toward improved survival and significantly reduced contents of lung nitrite/nitrate (NO(x)) and liver malondialdehyde, the blockade of nNOS at 8h had no effect on these parameters.	Nitrates	132-139	nitric oxide synthase 1, neuronal	Mus musculus	6-10
21226927-20	2011	In addition, medication with nitrates reduced the risk of being CLR.	Nitrates	29-37	doublecortin like kinase 3	Homo sapiens	64-67
20706193-6	2011	In Ang II + HS fed KO mice, the urinary excretion rate of nitrite/nitrate (U(NOx)V) markedly increased but 8-isoprostane excretion rate remained unchanged.	Nitrates	66-73	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	3-9
21737912-6	2011	Reverse transcription-polymerase chain reaction (RT-PCR) showed that the expression levels of GmATG8i and GmATG4 increase in a starvation medium, but at a null or marginal level in a sucrose/nitrate-rich medium.	Nitrates	191-198	autophagy-related protein 8i	Glycine max	94-101
20540036-9	2011	Nitrate levels were negatively associated with Hcy, ADMA and LpPLA2 activity.	Nitrates	0-7	phospholipase A2 group VII	Homo sapiens	61-67
20967313-4	2010	Moreover, our simulation results suggest that the experimentally observed complex UO(2)(NO(3))(2) 2TBP is formed after the migration of the aforementioned complexes into the organic phase by means of a reorganization of the nitrate binding mode from mono to bidentate which removes the excess oxygen atoms bound to uranyl.	Nitrates	224-231	TATA-box binding protein	Homo sapiens	99-102
21397917-3	2011	Bottom nitrate concentrations (5.7-16.8 muM; avg.	Nitrates	7-14	latexin	Homo sapiens	40-43
22097076-1	2011	The present study aimed at developing a universal method for the localization of critical source areas (CSAs) of diffuse nitrate (NO3-) pollution in rural catchments with low data availability.	Nitrates	121-128	NBL1, DAN family BMP antagonist	Homo sapiens	130-133
21090606-3	2010	This study investigates the intake of perchlorate, nitrate, and iodide attributable to direct and indirect tap water consumption.	Nitrates	51-58	nuclear RNA export factor 1	Homo sapiens	107-110
21045638-3	2010	Recently, an alternative pathway for nitric oxide generation was discovered, wherein the inorganic anions nitrate (NO3) and nitrite (NO2), most often considered inert end products from nitric oxide generation, can be reduced back to nitric oxide and other bioactive nitrogen oxide species.	Nitrates	106-113	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
21090606-10	2010	Using individual tap water consumption data and body weight, we estimated the median perchlorate, nitrate, and iodide dose attributable to tap water as 9.11, 11300, and 43.3 ng/kg-day, respectively, for U.S. adults.	Nitrates	98-105	nuclear RNA export factor 1	Homo sapiens	139-142
21360884-7	2010	When COD/N were 6-7, it can meet the requirement for carbon source during aerobic denitrification, the removal rate of nitrate nitrogen and COD were up to 96%, 85% respectively.	Nitrates	119-126	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	5-8
20662039-5	2010	Nitrate (NO3-), can be considered as an alternative electron acceptor, which can support oxidation of As(III) to As(V) by denitrifying bacteria.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
21265445-7	2010	Whole-stream nitrate uptake and denitrification in our study streams closely followed first-order uptake kinetics, indicating that NO3 uptake is limited by delivery of substrate (NO3) to the organisms involved in uptake or denitrification.	Nitrates	13-20	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
20815776-6	2010	It is shown that palmitate caused induction of iNOS resulting in increased nitrite/nitrate concentration and slight increase in TG content.	Nitrates	83-90	nitric oxide synthase 2	Rattus norvegicus	47-51
20738805-3	2010	Nitrate reductase enzyme activity is responsible for the reduction of nitrate to nitrite, and nitrate is the major form of nitrogen assimilated in plants.	Nitrates	70-77	nitrate reductase [NADH] 1	Zea mays	0-17
20837581-2	2010	(2010) identified AtNRT1.8 as a membrane transporter involved in the control of long-distance transport of nitrate between roots and shoot.	Nitrates	107-114	nitrate transporter 1.1	Arabidopsis thaliana	18-24
21589287-2	2010	Given that the Zn-O interactions [2.4926 (15) and 2.6673 (15) A] can be considered as weakly bonding and the nitrate ions share the same C(2) axis of the Zn(dpp)(2) fragment (dpp is 4,7-diphenyl-1,10-phenanthroline), these anions belong to the coordination sphere of Zn(2+), leading to a complex with an overall coordination number of 8 for the metal ion.	Nitrates	109-116	dentin sialophosphoprotein	Homo sapiens	157-160
20386496-6	2010	Negative correlations between nitrates, nitrotyrosine, and MLC2 levels were observed.	Nitrates	30-38	myosin light chain 12B	Homo sapiens	59-63
20880842-10	2010	We conclude that HpUre2 is involved in salt tolerance and also in nitrate assimilation gene derepression via Ca(2+) homeostasis regulation and calcineurin activation, which control the levels of Gat1.	Nitrates	66-73	Gat1p	Saccharomyces cerevisiae S288C	195-199
19911291-4	2010	The potential consequences, in terms of water pollution from nitrates of a BMP expressly applied to reduce P pollution are also discussed.	Nitrates	61-69	bone morphogenetic protein 1	Homo sapiens	75-78
20964367-7	2010	The pattern of nitrate yield is believed to be attributable to the fact that when urea serves as the source of reduced-N, entry into the reactions that describe chlorination of ammoniacal nitrogen is through NCl3, whereas when NH3 is the source of reduced-N, entry to these reactions is through NH2Cl.	Nitrates	15-22	calpain 5	Homo sapiens	208-212
20854429-7	2010	Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase.	Nitrates	84-92	FAM111 trypsin like peptidase B	Homo sapiens	17-21
20854429-7	2010	Ammonia, ANP and cANP((4-23)) added separately, each stimulated formation of NO(x) (nitrates + nitrites) which was associated with up-regulation of the activity [cANP((4-23))] or/and expression (ammonia) of the endothelial isoform of nitric oxide synthase.	Nitrates	84-92	FAM111 trypsin like peptidase B	Homo sapiens	162-166
20845308-3	2010	The nitrate reductase (NR) gene, which plays a central role in nitrate acquisition, was the target gene for this research.	Nitrates	4-11	nitrate reductase [NADH] 1	Zea mays	23-25
20822503-2	2010	In Arabidopsis, members of the chloride channel (CLC) family located in intracellular organelles have been shown to be required for nitrate homeostasis or pH adjustment, and previous results indicated that AtCLCc is involved in nitrate accumulation.	Nitrates	132-139	chloride channel C	Arabidopsis thaliana	206-212
20822503-2	2010	In Arabidopsis, members of the chloride channel (CLC) family located in intracellular organelles have been shown to be required for nitrate homeostasis or pH adjustment, and previous results indicated that AtCLCc is involved in nitrate accumulation.	Nitrates	228-235	chloride channel C	Arabidopsis thaliana	206-212
20946657-3	2010	The level of methemoglobin in the blood is the biomarker often used in research for assessing exposure to nitrates.	Nitrates	106-114	hemoglobin subunit gamma 2	Homo sapiens	13-26
20935411-3	2010	There are some methods to treat CSX including statins, b blocker, angiotensin converting enzyme inhibitors, nitrates, estrogen, and so on.	Nitrates	108-116	NK2 homeobox 5	Homo sapiens	32-35
20694272-8	2010	TPA was applied to monitoring photochemical OH production by nitrate, nitrite and dissolved organic matter (DOM), and OH quenching rate constants measured for DOM were similar to results from previous studies.	Nitrates	61-68	plasminogen activator, tissue type	Homo sapiens	0-3
20131084-4	2010	PCNB at an initial concentration of 13 muM was transformed to PCA simultaneously with nitrate reduction but only after the nitrate concentration was at or below 20 mg N/l.	Nitrates	86-93	latexin	Homo sapiens	39-42
20498409-12	2010	In contrast, BALF nitrite+nitrate levels were decreased in apoA-I(-/-) mice.	Nitrates	26-33	apolipoprotein A-I	Mus musculus	59-65
20561257-1	2010	AtNRT2.1, a polypeptide of the Arabidopsis thaliana two-component inducible high-affinity nitrate transport system (IHATS), is located within the plasma membrane.	Nitrates	90-97	nitrate transporter 2:1	Arabidopsis thaliana	0-8
20547419-5	2010	Circulation of Arabian Sea high salinity waters with nitrate deficit could also be seen from low N/P ratio with a minimum of 8.9 in spring and a maximum of 13.6 in winter.	Nitrates	53-60	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	23-26
20561257-2	2010	The monomeric form of AtNRT2.1 has been reported to be the most abundant form, and was suggested to be the form that is active in nitrate transport.	Nitrates	130-137	nitrate transporter 2:1	Arabidopsis thaliana	22-30
20598093-0	2010	The proline 160 in the selectivity filter of the Arabidopsis NO(3)(-)/H(+) exchanger AtCLCa is essential for nitrate accumulation in planta.	Nitrates	109-116	chloride channel A	Arabidopsis thaliana	85-91
20598093-3	2010	In contrast to other CLC family members, AtCLCa transports nitrate coupled to protons.	Nitrates	59-66	chloride channel A	Arabidopsis thaliana	41-47
20561257-9	2010	This result, together with the finding that the oligomer is absent from NRT2.1 or NAR2.1 mutants, suggests that this complex, rather than monomeric AtNRT2.1, is the form that is active in IHATS nitrate transport.	Nitrates	194-201	nitrate transporter 2:1	Arabidopsis thaliana	148-156
20561257-10	2010	The molecular mass of the intact oligomer suggests that the functional unit for high-affinity nitrate influx may be a tetramer consisting of two subunits each of AtNRT2.1 and AtNAR2.1.	Nitrates	94-101	nitrate transporter 2:1	Arabidopsis thaliana	162-170
20668061-0	2010	Multiple regulatory elements in the Arabidopsis NIA1 promoter act synergistically to form a nitrate enhancer.	Nitrates	92-99	nitrate reductase 1	Arabidopsis thaliana	48-52
20668061-4	2010	A 1.8-kb promoter fragment from the nitrate reductase gene NIA1 was identified that acts as a nitrate enhancer when fused to a 35S minimal promoter.	Nitrates	36-43	nitrate reductase 1	Arabidopsis thaliana	59-63
20668061-10	2010	These findings were validated in transgenic Arabidopsis plants and identify a cis-regulatory module containing three elements that comprise a nitrate enhancer in the NIA1 promoter.	Nitrates	142-149	nitrate reductase 1	Arabidopsis thaliana	166-170
20870960-5	2010	In this study, LCI1 was placed under the control of the nitrate reductase promoter, allowing for the induction of LCI1 expression by nitrate in the absence of other CCM components.	Nitrates	56-63	uncharacterized protein	Chlamydomonas reinhardtii	15-19
20598093-8	2010	Our results confirm the significance of this amino acid in the conserved selectivity filter of CLC proteins and highlight the importance of the proline in AtCLCa for nitrate metabolism in Arabidopsis.	Nitrates	166-173	chloride channel A	Arabidopsis thaliana	155-161
20870960-5	2010	In this study, LCI1 was placed under the control of the nitrate reductase promoter, allowing for the induction of LCI1 expression by nitrate in the absence of other CCM components.	Nitrates	56-63	uncharacterized protein	Chlamydomonas reinhardtii	114-118
21588529-2	2010	The Co(II) atom (site symmetry 2) is six-coordinate in a distorted octahedral configuration bonded by two N and two O atoms from two (2-amino-phen-yl)methanol ligands and two O atoms from the two nitrate anions.	Nitrates	196-203	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-10
20449593-4	2010	For this, we equipped a recently developed amiRNA expression vector with the NIT1 promoter, which is repressed by ammonium and activated by nitrate.	Nitrates	140-147	uncharacterized protein	Chlamydomonas reinhardtii	77-81
20449593-6	2010	HSF1 transcripts in transformants were already reduced ~2 h after transfer from ammonium to nitrate-containing medium.	Nitrates	92-99	uncharacterized protein	Chlamydomonas reinhardtii	0-4
20449593-8	2010	HSF1 levels recovered partly when transformant cells were shifted back to ammonium for 72 h. Transformants developed thermosensitivity only on nitrate and thermosensitivity correlated with strong reduction in HSF1 levels, hence supporting our earlier conclusion that HSF1 is a key regulator for thermotolerance in Chlamydomonas.	Nitrates	143-150	uncharacterized protein	Chlamydomonas reinhardtii	0-4
21090302-1	2010	The PBS material that in the form of insoluble biodegradable polymers pellets was investigated as the solid carbon source and the biofilm carrier for nitrate removal from wastewater.	Nitrates	150-157	cholinergic receptor muscarinic 3	Homo sapiens	4-7
20608721-0	2010	Identification of organic nitrates in the NO3 radical initiated oxidation of alpha-pinene by atmospheric pressure chemical ionization mass spectrometry.	Nitrates	26-34	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
20575535-1	2010	A novel instrument is described that quantifies total particle-phase organic nitrates in real time with a detection limit of 0.11 microg m(-3) min(-1), 45 ppt min(-1) (-ONO(2)).	Nitrates	77-85	CD59 molecule (CD59 blood group)	Homo sapiens	143-149
20551918-3	2010	Rats receiving co-treatment with dietary BH(4) and eNOS gene transfer (the [eNOS, +BH(4)] group) had greater eNOS expression, phospho-eNOS expression (Ser(1177)), Ca(2+)-dependent NOS activity, and nitrite + nitrate concentrations in the ischemic gastrocnemius than did rats receiving AdeNOS alone.	Nitrates	208-215	nitric oxide synthase 3	Rattus norvegicus	51-55
20563339-0	2010	[NO3[symbol: see text]{(en)Pt(2,2"-bpz)}3]NO3(SO4)2: snapshot of nitrate insertion into a cationic Pt3 metallacycle or simply a packing effect?	Nitrates	65-72	zinc finger protein 135	Homo sapiens	99-102
20575535-1	2010	A novel instrument is described that quantifies total particle-phase organic nitrates in real time with a detection limit of 0.11 microg m(-3) min(-1), 45 ppt min(-1) (-ONO(2)).	Nitrates	77-85	CD59 molecule (CD59 blood group)	Homo sapiens	159-165
20085572-9	2010	Although CNP 100 nM and 1 microM was observed to increase nitrite + nitrate (stable metabolites of NO) production in HUVEC two-fold above basal level, the soluble guanylyl cyclase inhibitor ODQ 10 microM did not significantly modify CNP-stimulated cGMP accumulation suggesting that endothelial actions of CNP may be NO-independent.	Nitrates	68-75	natriuretic peptide C	Homo sapiens	9-12
20682995-5	2010	Interestingly, the beta-catenin system was activated by the nitro-oxy derivative as well as by benzyl nitrate alone more potently than by the parent compound celecoxib, suggesting a possible regulatory role for NO.	Nitrates	102-109	catenin beta 1	Homo sapiens	19-31
20444232-0	2010	Identification of a nitrate-responsive cis-element in the Arabidopsis NIR1 promoter defines the presence of multiple cis-regulatory elements for nitrogen response.	Nitrates	20-27	nitrite reductase 1	Arabidopsis thaliana	70-74
19496011-4	2010	Ninety-seven percent of the water samples showed nitrate (NO3-) concentrations above the human affected value (13 mg l(-1) NO3-), while 15% exceeded the maximum acceptable level (50 mg l(-1) NO3-) according to WHO regulations.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
20444232-2	2010	To identify the cis-acting DNA element involved in nitrate-responsive gene expression, we analyzed the promoter of the Arabidopsis gene encoding nitrite reductase (NIR1).	Nitrates	51-58	nitrite reductase 1	Arabidopsis thaliana	145-162
20587040-10	2010	PDE-5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death.	Nitrates	37-44	phosphodiesterase 5A	Homo sapiens	0-5
20444232-2	2010	To identify the cis-acting DNA element involved in nitrate-responsive gene expression, we analyzed the promoter of the Arabidopsis gene encoding nitrite reductase (NIR1).	Nitrates	51-58	nitrite reductase 1	Arabidopsis thaliana	164-168
20444232-3	2010	A region from positions -188 to -1, relative to the translation start site, was found to contain at least one cis-element necessary for the nitrate-dependent activation of the promoter, in which the activity of nitrate transporter NRT2.1 and/or NRT2.2 plays a critical role.	Nitrates	140-147	nitrate transporter 2:1	Arabidopsis thaliana	231-237
20444232-3	2010	A region from positions -188 to -1, relative to the translation start site, was found to contain at least one cis-element necessary for the nitrate-dependent activation of the promoter, in which the activity of nitrate transporter NRT2.1 and/or NRT2.2 plays a critical role.	Nitrates	140-147	nitrate transporter 2:1	Arabidopsis thaliana	231-235
20444232-4	2010	To define this nitrate-responsive cis-element (NRE), we compared the sequences of several nitrite reductase gene promoters from various higher plants and identified a conserved sequence motif as the putative NRE.	Nitrates	15-22	nitrite reductase 1	Arabidopsis thaliana	90-107
20444232-6	2010	Furthermore, mutations within this conserved motif in the native NIR1 promoter markedly reduced the nitrate-responsive activity of the promoter, indicating that the 43-bp sequence is an NRE that is both necessary and sufficient for nitrate-responsive transcription.	Nitrates	100-107	nitrite reductase 1	Arabidopsis thaliana	65-69
20444232-6	2010	Furthermore, mutations within this conserved motif in the native NIR1 promoter markedly reduced the nitrate-responsive activity of the promoter, indicating that the 43-bp sequence is an NRE that is both necessary and sufficient for nitrate-responsive transcription.	Nitrates	232-239	nitrite reductase 1	Arabidopsis thaliana	65-69
20444232-7	2010	We also show that both the native NIR1 promoter and the synthetic promoter display a similar level of sensitivity to nitrate, but respond differentially to exogenously supplied glutamine, indicating independent modulation of NIR1 expression by NRE-mediated nitrate induction and feedback repression mediated by other cis-element(s).	Nitrates	117-124	nitrite reductase 1	Arabidopsis thaliana	34-38
20444232-7	2010	We also show that both the native NIR1 promoter and the synthetic promoter display a similar level of sensitivity to nitrate, but respond differentially to exogenously supplied glutamine, indicating independent modulation of NIR1 expression by NRE-mediated nitrate induction and feedback repression mediated by other cis-element(s).	Nitrates	257-264	nitrite reductase 1	Arabidopsis thaliana	225-229
20669724-5	2010	The results highlighted a significant reductive microbial activity in seepage water from either denitrification or dissimilatory nitrate reduction to ammonium (DNRA), leading to nitrate (NO3(-)) consumption.	Nitrates	129-136	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
20669724-5	2010	The results highlighted a significant reductive microbial activity in seepage water from either denitrification or dissimilatory nitrate reduction to ammonium (DNRA), leading to nitrate (NO3(-)) consumption.	Nitrates	178-185	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
20499882-5	2010	Low concentrations of the NO donor, DETA NONOate (&lt;200 microM), exclusively nitrate Tyr327 within the tetramerization domain promoting p53 oligomerization, nuclear accumulation, and increased DNA-binding activity without p53 Ser15 phosphorylation.	Nitrates	79-86	tumor protein p53	Homo sapiens	138-141
20587040-10	2010	PDE-5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death.	Nitrates	45-52	phosphodiesterase 5A	Homo sapiens	0-5
20627068-3	2010	The dual transporter NRT1.1 uses both nitrate and the plant hormone auxin as substrates, enabling soil nitrate availability to regulate auxin-driven lateral root development.	Nitrates	38-45	immunoglobulin superfamily member 9	Homo sapiens	21-25
20627068-3	2010	The dual transporter NRT1.1 uses both nitrate and the plant hormone auxin as substrates, enabling soil nitrate availability to regulate auxin-driven lateral root development.	Nitrates	103-110	immunoglobulin superfamily member 9	Homo sapiens	21-25
20627075-0	2010	Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	37-41
20627075-2	2010	In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor.	Nitrates	27-34	nitrate transporter 1.1	Arabidopsis thaliana	20-24
20627075-2	2010	In Arabidopsis, the NRT1.1 nitrate transporter is crucial for nitrate signaling governing root growth, and has been proposed to act as a nitrate sensor.	Nitrates	62-69	nitrate transporter 1.1	Arabidopsis thaliana	20-24
20627075-4	2010	Herein we show that NRT1.1 not only transports nitrate but also facilitates uptake of the phytohormone auxin.	Nitrates	47-54	nitrate transporter 1.1	Arabidopsis thaliana	20-24
20627075-5	2010	Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport.	Nitrates	10-17	nitrate transporter 1.1	Arabidopsis thaliana	27-31
20627075-5	2010	Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport.	Nitrates	10-17	nitrate transporter 1.1	Arabidopsis thaliana	108-112
20627075-5	2010	Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport.	Nitrates	90-97	nitrate transporter 1.1	Arabidopsis thaliana	27-31
20627075-5	2010	Moreover, nitrate inhibits NRT1.1-dependent auxin uptake, suggesting that transduction of nitrate signal by NRT1.1 is associated with a modification of auxin transport.	Nitrates	90-97	nitrate transporter 1.1	Arabidopsis thaliana	108-112
20627075-7	2010	Mutation of NRT1.1 enhances both auxin accumulation in lateral roots and growth of these roots at low, but not high, nitrate concentration.	Nitrates	117-124	nitrate transporter 1.1	Arabidopsis thaliana	12-16
20627075-8	2010	Thus, we propose that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots.	Nitrates	66-73	nitrate transporter 1.1	Arabidopsis thaliana	22-28
20211595-7	2010	This role of AOX in the mitochondrial plasticity makes logical the localization of Aox1 in a nitrate assimilation gene cluster.	Nitrates	93-100	uncharacterized protein	Chlamydomonas reinhardtii	83-87
19565320-6	2010	At univariate Cox regression analysis, a reduced probability of VVS occurrence after nitrates was associated with greater systolic blood pressure and body mass index values, to male gender and smoking.	Nitrates	85-93	cytochrome c oxidase subunit 8A	Homo sapiens	14-17
20092674-6	2010	Plasma intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 correlated positively with plasma 3-nitrotyrosine (p=0.019) and nitrite/nitrate (p=0.019), respectively.	Nitrates	151-158	vascular cell adhesion molecule 1	Homo sapiens	45-78
20394470-0	2010	Co-possession of phosphodiesterase type-5 inhibitors (PDE5-I) with nitrates.	Nitrates	67-75	phosphodiesterase 5A	Homo sapiens	54-58
20394470-1	2010	OBJECTIVE: Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group.	Nitrates	106-114	phosphodiesterase 5A	Homo sapiens	74-78
20394470-7	2010	When co-possessed prescriptions were defined by overlapping exposure periods, the proportion of PDE5-I patients with co-possessed nitrates ranged from 1.44% (tadalafil) to 1.72% (vardenafil) and 2.13% (sildenafil).	Nitrates	130-138	phosphodiesterase 5A	Homo sapiens	96-100
20394470-9	2010	The majority (54.29%) of co-possessed PDE5-I and nitrate prescriptions had the nitrate dispensed prior to the PDE5-I prescription identified in the study cohort.	Nitrates	49-56	phosphodiesterase 5A	Homo sapiens	110-114
20394470-9	2010	The majority (54.29%) of co-possessed PDE5-I and nitrate prescriptions had the nitrate dispensed prior to the PDE5-I prescription identified in the study cohort.	Nitrates	79-86	phosphodiesterase 5A	Homo sapiens	38-42
20226578-4	2010	The implementation of a sulphur emission control area (SECA) in the North Sea, as it was implemented at the end of 2007, directly results in reduced sulphur dioxide and sulphate aerosol concentrations while nitrate aerosol concentrations are slightly increased.	Nitrates	207-214	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	74-77
20092674-7	2010	Furthermore, plasma interleukin-1beta also positively correlated with plasma nitrite/nitrate (p=0.003).	Nitrates	85-92	interleukin 1 beta	Homo sapiens	20-37
20430631-2	2010	We report here the inhibitory capacities of some organic nitrates against two human (hCA) isozymes, hCA I and hCA II.	Nitrates	57-65	HCA1	Homo sapiens	85-88
20430762-3	2010	CLC-a, a member of the CLC family of anion transporters, is critically involved in this nitrate storage in the vacuole, while other CLC family members apparently have different roles in diverse cell organelles.	Nitrates	88-95	chloride channel A	Arabidopsis thaliana	0-5
20430762-5	2010	CLC-b conducted strongly outwardly rectifying anionic currents that were largest in the presence of nitrate.	Nitrates	100-107	chloride channel B	Arabidopsis thaliana	0-5
20036660-2	2010	In Arabidopsis thaliana, AtClC-a has been recently shown to be a NO(3)(-)/H(+) antiporter critical for nitrate transport into the vacuoles.	Nitrates	103-110	chloride channel A	Arabidopsis thaliana	25-32
20430631-2	2010	We report here the inhibitory capacities of some organic nitrates against two human (hCA) isozymes, hCA I and hCA II.	Nitrates	57-65	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	100-116
20298504-4	2010	In both strains, FNR was required for normal fumarate- and nitrate-dependent respiration.	Nitrates	59-66	fnr	Vibrio fischeri ES114	17-20
20304912-0	2010	Point mutation of a plastidic invertase inhibits development of the photosynthetic apparatus and enhances nitrate assimilation in sugar-treated Arabidopsis seedlings.	Nitrates	106-113	alkaline/neutral invertase	Arabidopsis thaliana	30-39
20378150-9	2010	Nitrate reduction was not significantly inhibited by acenaphthene and 4-NP and furthermore was resistant to LAS toxicity (105 mgL(-1)).	Nitrates	0-7	LLGL scribble cell polarity complex component 1	Homo sapiens	126-132
19533679-2	2010	Here, we show that training rats in an object recognition (OR) learning task rapidly increased nitrites/nitrates (NOx) content in the CA1 region of the dorsal hippocampus while posttraining intra-CA1 microinfusion of the neuronal NO synthase (nNOS) inhibitor L-NN hindered OR LTM retention without affecting memory retrieval or other behavioral variables.	Nitrates	104-112	carbonic anhydrase 1	Rattus norvegicus	134-137
20442374-1	2010	Nitrate assimilation in plants and related organisms is a highly regulated and conserved pathway in which the enzyme nitrate reductase (NR) occupies a central position.	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	117-134
20501909-0	2010	The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance.	Nitrates	16-23	nitrate transporter 1.1	Arabidopsis thaliana	36-40
20501909-0	2010	The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance.	Nitrates	16-23	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	87-90
20501909-3	2010	NRT1.8 is upregulated by nitrate.	Nitrates	25-32	nitrate transporter 1.1	Arabidopsis thaliana	0-4
20501909-6	2010	Electrophysiological and nitrate uptake analyses using Xenopus laevis oocytes showed that NRT1.8 mediates low-affinity nitrate uptake.	Nitrates	25-32	nitrate transporter 1.1	Arabidopsis thaliana	90-94
20501909-6	2010	Electrophysiological and nitrate uptake analyses using Xenopus laevis oocytes showed that NRT1.8 mediates low-affinity nitrate uptake.	Nitrates	119-126	nitrate transporter 1.1	Arabidopsis thaliana	90-94
20501909-7	2010	Functional disruption of NRT1.8 significantly increased the nitrate concentration in xylem sap.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	25-29
20501909-7	2010	Functional disruption of NRT1.8 significantly increased the nitrate concentration in xylem sap.	Nitrates	60-67	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	91-94
20501909-8	2010	These data together suggest that NRT1.8 functions to remove nitrate from xylem vessels.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	33-37
20501909-9	2010	Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	15-19
20501909-9	2010	Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype.	Nitrates	169-176	nitrate transporter 1.1	Arabidopsis thaliana	15-19
20501909-9	2010	Interestingly, NRT1.8 was the only nitrate assimilatory pathway gene that was strongly upregulated by cadmium (Cd(2+)) stress in roots, and the nrt1.8-1 mutant showed a nitrate-dependent Cd(2+)-sensitive phenotype.	Nitrates	169-176	nitrate transporter 1.1	Arabidopsis thaliana	144-148
20501909-11	2010	These data suggest that NRT1.8-regulated nitrate distribution plays an important role in Cd(2+) tolerance.	Nitrates	41-48	nitrate transporter 1.1	Arabidopsis thaliana	24-28
20442374-1	2010	Nitrate assimilation in plants and related organisms is a highly regulated and conserved pathway in which the enzyme nitrate reductase (NR) occupies a central position.	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	136-138
20225831-3	2010	Two structural series have been prepared by reacting in water rare earth nitrates (Ln(III) = La, Pr, Nd, Sm, Eu, Gd, Dy, Ho) with K(3)[M(CN)(6)] (M(III) = Fe, Co) in the presence of hexamethylenetetramine (hmt).	Nitrates	73-81	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	86-89
20448437-8	2010	In contrast, endothelial nitric oxide synthase (eNOS) was expressed in both types of EPCs, and both cell types could produce nitric oxide (NO), as judged by measuring the total amounts of nitrites and nitrates in culture media.	Nitrates	201-209	nitric oxide synthase 3	Homo sapiens	13-46
19939965-0	2010	Degradation of leucine zipper-positive isoform of MYPT1 may contribute to development of nitrate tolerance.	Nitrates	89-96	protein phosphatase 1, regulatory subunit 12A	Mus musculus	50-55
19939965-1	2010	AIMS: A depressed cGMP-dependent protein kinase (PKG) activity is implicated in nitrate tolerance.	Nitrates	80-87	protein kinase cGMP-dependent 1	Homo sapiens	49-52
19939965-2	2010	The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance.	Nitrates	199-206	protein phosphatase 1, regulatory subunit 12A	Mus musculus	82-117
19939965-2	2010	The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance.	Nitrates	199-206	protein phosphatase 1, regulatory subunit 12A	Mus musculus	119-124
19939965-2	2010	The present study determines whether the leucine zipper-positive (LZ+) isoform of myosin phosphatase target subunit 1 (MYPT1), a key target protein for PKG actions, is involved in the development of nitrate tolerance.	Nitrates	199-206	protein kinase cGMP-dependent 1	Homo sapiens	152-155
19939965-7	2010	Protein levels of MYPT1 (LZ+), but not of PP1Cdelta, were significantly reduced in in vitro and in vivo nitrate-tolerant arteries.	Nitrates	104-111	protein phosphatase 1, regulatory subunit 12A	Mus musculus	18-23
19939965-11	2010	CONCLUSION: This study demonstrates that a reduction in the protein level of MYPT1 (LZ+) is involved in nitrate tolerance.	Nitrates	104-111	protein phosphatase 1, regulatory subunit 12A	Mus musculus	77-82
20701008-2	2010	It is well known the toxic action of nitrate upon organisms, by formatting methemoglobin and N-nitroso compounds.	Nitrates	37-44	hemoglobin subunit gamma 2	Homo sapiens	75-88
20157049-7	2010	Improvement of vascular function in this particular model of arterial hypertension by pentaerythritol tetranitrate largely depends on the induction of the antioxidant enzyme HO-1 and identifies pentaerythritol tetranitrate, in contrast to isosorbide-5 mononitrate, as an organic nitrate able to improve rather than to worsen endothelial function.	Nitrates	107-114	heme oxygenase 1	Rattus norvegicus	174-178
20701008-8	2010	The maximum methemoglobin level was 60% and the minimum value of nitrate concentration in the water samples was 396 mg NO3-/L.	Nitrates	65-72	NBL1, DAN family BMP antagonist	Homo sapiens	119-122
20701008-9	2010	CONCLUSIONS: We established a direct correlation between the level of methemoglobin and the nitrate concentrations in water samples.	Nitrates	92-99	hemoglobin subunit gamma 2	Homo sapiens	70-83
20163092-1	2010	We examined the kinetics of nitrate reduction by periplasmic nitrate reductase (Nap) by using protein film voltammetry and solution assays.	Nitrates	28-35	catenin beta like 1	Homo sapiens	80-83
20307293-2	2010	Accordingly, metabolic investigations of the microbial biofilm communities of human dental plaque have focused on aerobic respiration and acid fermentation of carbohydrates, even though it is known that the oral habitat is constantly exposed to nitrate (NO3-) concentrations in the millimolar range and that dental plaque houses bacteria that can reduce this NO3- to nitrite (NO2-).	Nitrates	245-252	NBL1, DAN family BMP antagonist	Homo sapiens	254-257
20067832-3	2010	PCB treatment reduced inducible nitric oxide synthase (iNOS) expression as well as levels of nitrite/nitrate in both cell lines.	Nitrates	101-108	pyruvate carboxylase	Homo sapiens	0-3
20142497-0	2010	Nitrate-responsive miR393/AFB3 regulatory module controls root system architecture in Arabidopsis thaliana.	Nitrates	0-7	auxin signaling F-box 3	Arabidopsis thaliana	26-30
20142497-7	2010	However, only AFB3 was regulated by nitrate in roots under our experimental conditions.	Nitrates	36-43	auxin signaling F-box 3	Arabidopsis thaliana	14-18
20142497-8	2010	Analysis of the expression of this miR393/AFB3 module, revealed an incoherent feed-forward mechanism that is induced by nitrate and repressed by N metabolites generated by nitrate reduction and assimilation.	Nitrates	120-127	auxin signaling F-box 3	Arabidopsis thaliana	42-46
20142497-8	2010	Analysis of the expression of this miR393/AFB3 module, revealed an incoherent feed-forward mechanism that is induced by nitrate and repressed by N metabolites generated by nitrate reduction and assimilation.	Nitrates	172-179	auxin signaling F-box 3	Arabidopsis thaliana	42-46
20142497-9	2010	To understand the functional role of this N-regulatory module for plant development, we analyzed the RSA response to nitrate in AFB3 insertional mutant plants and in miR393 overexpressors.	Nitrates	117-124	auxin signaling F-box 3	Arabidopsis thaliana	128-132
20142497-11	2010	Interestingly, regulation of RSA by nitrate was specifically mediated by AFB3, indicating that miR393/AFB3 is a unique N-responsive module that controls root system architecture in response to external and internal N availability in Arabidopsis.	Nitrates	36-43	auxin signaling F-box 3	Arabidopsis thaliana	73-77
20142497-11	2010	Interestingly, regulation of RSA by nitrate was specifically mediated by AFB3, indicating that miR393/AFB3 is a unique N-responsive module that controls root system architecture in response to external and internal N availability in Arabidopsis.	Nitrates	36-43	auxin signaling F-box 3	Arabidopsis thaliana	102-106
19694900-9	2010	However, the BNP decrease was larger in the high-dose nitrate group (P &lt; 0.0001).	Nitrates	54-61	natriuretic peptide B	Homo sapiens	13-16
19694900-10	2010	The larger decrease in BNP in the high-dose nitrate group was already apparent 12 h after the initiation of treatment.	Nitrates	44-51	natriuretic peptide B	Homo sapiens	23-26
19694900-11	2010	After 48 h BNP values decreased by an average of 29 +/- 4.9% in the high-dose nitrate strategy group compared to 15 +/- 5.4% during standard therapy.	Nitrates	78-85	natriuretic peptide B	Homo sapiens	11-14
20154005-5	2010	Expressed in Xenopus oocytes, AtALMT12 facilitates chloride and nitrate currents, but not those of organic solutes.	Nitrates	64-71	aluminum-activated, malate transporter 12	Arabidopsis thaliana	30-38
20006999-8	2010	Computer simulations that utilized the measured kinetic values confirmed this interpretation, and revealed that the V346I iNOS has an enhanced NADPH-dependent NO dioxygenase activity that converts almost 1 NO to nitrate for every NO that the enzyme releases into solution.	Nitrates	212-219	nitric oxide synthase 2	Homo sapiens	122-126
20147370-5	2010	Homologs of these genes exist in other plant species, including a family of four genes of unknown function in Arabidopsis thaliana (LSU1-4), of which two were reported as strongly induced by S-deficit and to a lesser extent by salt stress and nitrate limitation.	Nitrates	243-250	response to low sulfur 1	Arabidopsis thaliana	132-138
20065149-10	2010	Together, these results suggest that mPGES-1-derived PGE(2) confers protection against DOCA-salt hypertension likely via inhibition of oxidative stress or stimulation of superoxide dismutase-3 and urinary nitrate/nitrite system.	Nitrates	205-212	prostaglandin E synthase	Mus musculus	37-44
20031186-3	2010	At the copper cathode, electroreduction of nitrate to ammonia was optimal near -1.4 V vs Hg/HgO.	Nitrates	43-50	homogentisate 1,2-dioxygenase	Homo sapiens	92-95
20142047-5	2010	It was demonstrated that xanthine oxidoreductase (XOR) and possibly other enzymes can catalyze nitrate reduction under normoxic conditions in vivo.	Nitrates	95-102	xanthine dehydrogenase	Mus musculus	25-48
20142047-5	2010	It was demonstrated that xanthine oxidoreductase (XOR) and possibly other enzymes can catalyze nitrate reduction under normoxic conditions in vivo.	Nitrates	95-102	xanthine dehydrogenase	Mus musculus	50-53
19184629-3	2010	In the present research, a survey of wells (n = 1,060) was undertaken in all 13 regions of the Kingdom of Saudi Arabia to assess the contained nitrate (NO(3)) levels.	Nitrates	143-150	NBL1, DAN family BMP antagonist	Homo sapiens	152-157
19184629-4	2010	The results indicated variation in nitrate levels from 1.1 to 884.0 mg/L as NO(3) throughout the Kingdom.	Nitrates	35-42	NBL1, DAN family BMP antagonist	Homo sapiens	76-81
19184629-6	2010	The results indicated that nitrate levels exceeded the maximum contaminant limits for drinking water (45 mg/L as NO(3)) in a number of wells (n = 213) in different regions of the Kingdom.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	113-118
20109206-1	2010	BACKGROUND: Tap water may be an important source of exposure to arsenic and nitrate.	Nitrates	76-83	nuclear RNA export factor 1	Homo sapiens	12-15
19449127-2	2010	Here, we report on the regulation of a cytosolic glutamine synthetase (CsGS) from Camellia sinensis (L.) O. Kuntze during developmental stages and light/dark conditions on the utilization of nitrate and ammonia.	Nitrates	191-198	glutamate-ammonia ligase	Homo sapiens	49-69
19932915-3	2010	In this paper we use Disjunctive Kriging to map the probability that the Nitrates Directive limit (91/676/EEC) is exceeded for the Nitrate Vulnerable Zone of the River Tagus alluvium aquifer.	Nitrates	73-81	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	106-109
19932915-3	2010	In this paper we use Disjunctive Kriging to map the probability that the Nitrates Directive limit (91/676/EEC) is exceeded for the Nitrate Vulnerable Zone of the River Tagus alluvium aquifer.	Nitrates	73-80	Ectrodactyly, ectodermal dysplasia, cleft lip/palate, 1	Homo sapiens	106-109
20933202-5	2010	Physiological levels of reactive nitrogen species (RNS) S-glutathiolate SERCA at Cys674 to increase its activity, and the augmentation of RNS in vascular diseases irreversibly oxidizes Cys674 or nitrates tyrosine residues at Tyr296-Tyr297, which are associated with loss of function.	Nitrates	195-203	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	72-77
21081219-3	2010	The formation of reactive oxygen and nitrogen species in the mitochondria and the subsequent inhibition of the nitrate-bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) appear to play a central role, at least for GTN, that is, bioactivated by ALDH-2.	Nitrates	111-118	aldehyde dehydrogenase 2 family member	Homo sapiens	178-184
20923091-4	2010	Regardless the type of media bed and the type of wastewater, nitrate was completely removed for nitrogen loading rates up to 1.3 g NO3-N/(m2 x day).	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
21081219-3	2010	The formation of reactive oxygen and nitrogen species in the mitochondria and the subsequent inhibition of the nitrate-bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) appear to play a central role, at least for GTN, that is, bioactivated by ALDH-2.	Nitrates	111-118	aldehyde dehydrogenase 2 family member	Homo sapiens	260-266
21081219-6	2010	In the past, attempts to avoid nitrate-induced side effects have focused on administration schedules that would allow a "nitrate-free interval"; in the future, the role of co-therapies with antioxidant compounds and of activation of endogeneous protective pathways such as the heme oxygenase 1 (HO-1) will need to be explored.	Nitrates	31-38	heme oxygenase 1	Homo sapiens	277-293
21081219-7	2010	However, the development of new nitrates, for example, tolerance-free aminoalkyl nitrates or combination of nitrate groups with established cardiovascular drugs like ACE inhibitors or AT(1)-receptor blockers (hybrid molecules) may be of great clinical interest.	Nitrates	32-40	angiotensin I converting enzyme	Homo sapiens	166-169
21081219-7	2010	However, the development of new nitrates, for example, tolerance-free aminoalkyl nitrates or combination of nitrate groups with established cardiovascular drugs like ACE inhibitors or AT(1)-receptor blockers (hybrid molecules) may be of great clinical interest.	Nitrates	32-39	angiotensin I converting enzyme	Homo sapiens	166-169
20331429-1	2010	Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast.	Nitrates	76-83	superoxide dismutase 1	Homo sapiens	225-245
20331429-1	2010	Infiltration of wheat (Triticum aestivum L.) seedling leaves with excess of nitrate, nitrite, or the NO donor sodium nitroprusside leads to increase both in content of hydroperoxide and activity of peroxidase and decrease in superoxide dismutase (SOD) activity in the leaf apoplast.	Nitrates	76-83	superoxide dismutase 1	Homo sapiens	247-250
19515062-2	2010	The aim of the present study was to determine the relationship between plasma concentrations of nitrite/nitrate (NO(x)) and endothelin (ET)-1 and non-invasive measures of peripheral vasodilator function in patients with coronary artery disease (CAD).	Nitrates	104-111	endothelin 1	Homo sapiens	124-141
21182762-9	2010	For example, the over-expression of a predicted gene hub encoding a transcription factor induced early in the cascade indeed leads to the modification of the kinetic nitrate response of sentinel genes such as NIR, NIA2, and NRT1.1, and several other transcription factors.	Nitrates	166-173	nitrate reductase 2	Arabidopsis thaliana	214-218
21182762-9	2010	For example, the over-expression of a predicted gene hub encoding a transcription factor induced early in the cascade indeed leads to the modification of the kinetic nitrate response of sentinel genes such as NIR, NIA2, and NRT1.1, and several other transcription factors.	Nitrates	166-173	nitrate transporter 1.1	Arabidopsis thaliana	224-230
20397415-2	2010	When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.	Nitrates	5-12	NBL1, DAN family BMP antagonist	Homo sapiens	269-272
20397415-2	2010	When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.	Nitrates	156-163	NBL1, DAN family BMP antagonist	Homo sapiens	269-272
20397415-2	2010	When nitrate was first introduced to the MBfR, denitrification took place on the shell side of the membranes immediately, and the effluent concentration of nitrate continuously decreased with 100% removal rate on day 45 under the influent nitrate concentration of 5 mg NO3- -N/L, which described the acclimating and enriching process of autohydrogenotrophic denitrification bacteria.	Nitrates	156-163	NBL1, DAN family BMP antagonist	Homo sapiens	269-272
20397415-4	2010	The results showed that nitrate reduction rate improved as H2 pressure increasing, and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3- -N/(m2 x day) without nitrite accumulation.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	195-198
20397415-4	2010	The results showed that nitrate reduction rate improved as H2 pressure increasing, and over 97% of total nitrogen removal rate was achieved when the nitrate loading increased from 0.17 to 0.34 g NO3- -N/(m2 x day) without nitrite accumulation.	Nitrates	149-156	NBL1, DAN family BMP antagonist	Homo sapiens	195-198
20923099-3	2010	For areas showing predicted nitrate concentrations in percolation water above the European Union (EU) groundwater quality standard of 50 mg NO3-N/L, effective agri-environmental reduction measures need to be derived and implemented to improve groundwater and surface water quality by 2015.	Nitrates	28-35	NBL1, DAN family BMP antagonist	Homo sapiens	140-143
19540016-5	2009	Induction of NIA2 transcription by nitrate was not influenced by HY5 or HYH.	Nitrates	35-42	nitrate reductase 2	Arabidopsis thaliana	13-17
19836459-8	2010	Recombinant MMP-9 was significantly activated by NTG and its dinitrate metabolites, indicating post-translation modification of this protein by organic nitrates.	Nitrates	152-160	matrix metallopeptidase 9	Homo sapiens	12-17
20351419-5	2010	The effect of aqueous matrix on As(V) sorption by the nanocrystalline LDH was found to increase in the order of nitrate &lt; silica &lt; sulfate &lt; carbonate &lt; phosphate.	Nitrates	112-119	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-37
19540016-0	2009	The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1.	Nitrates	79-86	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	31-34
19540016-0	2009	The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1.	Nitrates	79-86	HY5-homolog	Arabidopsis thaliana	39-42
19540016-0	2009	The bZIP transcription factors HY5 and HYH are positive regulators of the main nitrate reductase gene in Arabidopsis leaves, NIA2, but negative regulators of the nitrate uptake gene NRT1.1.	Nitrates	79-86	nitrate reductase 2	Arabidopsis thaliana	125-129
19801492-11	2009	The maintenance of cardioprotection in female mice lacking GPx1 post-I/R may be due to an improved ascorbate redox homeostasis and enhanced nitrate-to-nitrite conversion, which would predictably be accompanied by enhanced production of cardioprotective nitric oxide.	Nitrates	140-147	glutathione peroxidase 1	Mus musculus	59-63
18544592-9	2009	A significant decrease in mean total nitric oxide (NOx), nitrite, and nitrate levels was also found after G-CSF plus dexamethasone administration.	Nitrates	70-77	colony stimulating factor 3	Homo sapiens	106-111
20187384-8	2009	However, the areas of confined water with nitrate concentrations of 5-10 mg x L(-1), 10-15 mg x L(-1) and 15-20 mg x L(-1) were increased by 28.01%, 9.33%, and 0.48% respectively, while the areas of NO3- -N concentration (0-5 mg x L(-1)) was decreased by 37.82%.	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	199-202
19811527-10	2009	Nitrates/nitrites and TBARS, metabolites of MMPs activators, were increased in the diabetic placenta and reduced by 15dPGJ(2).	Nitrates	0-8	matrix metallopeptidase 2	Rattus norvegicus	44-48
20187385-8	2009	The NO3- -delta 15N values of 4.77% per hundred (n=9) show nitrate-nitrogen of S2 mainly originates from fertilizers from October, 2007 to March, 2008 and from July to October, 2008, while NO3- -delta 15N values of 3.16% per hundred +/- 0.39% per hundred (n=5) explain that the nitrate-nitrogen derives from the mixture of soil organic nitrogen and fertilizers from April to June, 2008.	Nitrates	59-66	NBL1, DAN family BMP antagonist	Homo sapiens	4-7
20516270-7	2009	We also show that the reduction in plasma MMP-9 levels was associated with a change in plasma nitrites/nitrates (NOx) concentration over the entire intervention (r = -0.38, p &lt; 0.05; week 12 vs. baseline).	Nitrates	103-111	matrix metallopeptidase 9	Homo sapiens	42-47
19820122-5	2009	Mice injected with Th1 cells developed progressive albuminuria over 21 d, histologic injury including 5.5 +/- 0.9% crescent formation/segmental necrosis, elevated urinary nitrate, and increased renal NOS2, CCL2, and CCL5 mRNA.	Nitrates	171-178	negative elongation factor complex member C/D, Th1l	Mus musculus	19-22
19732351-5	2009	The etr1-3 and ein2-1 mutants exhibited less reductions in LR length and number than wild-type plants in response to high nitrate concentration.	Nitrates	122-129	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	4-10
19524003-9	2009	Significant increases in expression of endothelial (eNOS) and inducible (iNOS) isoforms of NOS mRNA and protein occurred only at coma stages of encephalopathy accompanied by increased brain nitrite/nitrate concentrations.	Nitrates	198-205	nitric oxide synthase 2	Rattus norvegicus	73-77
19732351-5	2009	The etr1-3 and ein2-1 mutants exhibited less reductions in LR length and number than wild-type plants in response to high nitrate concentration.	Nitrates	122-129	NRAMP metal ion transporter family protein	Arabidopsis thaliana	15-19
19732351-6	2009	Expression of nitrate transporters AtNRT1.1 and AtNRT2.1 was upregulated and downregulated in response to high nitrate concentration, respectively.	Nitrates	14-21	nitrate transporter 1.1	Arabidopsis thaliana	35-43
20514237-0	2009	Nitrate responses of Arabidopsis cho1 mutants: obvious only when excess nitrate is supplied.	Nitrates	0-7	AINTEGUMENTA-like 5	Arabidopsis thaliana	33-37
20514237-0	2009	Nitrate responses of Arabidopsis cho1 mutants: obvious only when excess nitrate is supplied.	Nitrates	72-79	AINTEGUMENTA-like 5	Arabidopsis thaliana	33-37
20514237-1	2009	We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM).	Nitrates	160-167	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	56-59
20514237-1	2009	We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM).	Nitrates	160-167	AINTEGUMENTA-like 5	Arabidopsis thaliana	81-88
20514237-1	2009	We reported a loss-of-function of an Arabidopsis double AP2 transcription factor CHOTTO1 (CHO1) gene results in the altered responses to high concentrations of nitrate (approximately 50 mM).	Nitrates	160-167	AINTEGUMENTA-like 5	Arabidopsis thaliana	90-94
20514237-3	2009	The cho1 seedlings responded to nitrate up to 10 mM similarly to the wildtype, but the inhibitory effect of excess nitrate is less prominent in the mutants.	Nitrates	32-39	AINTEGUMENTA-like 5	Arabidopsis thaliana	4-8
19732351-6	2009	Expression of nitrate transporters AtNRT1.1 and AtNRT2.1 was upregulated and downregulated in response to high nitrate concentration, respectively.	Nitrates	14-21	nitrate transporter 2:1	Arabidopsis thaliana	48-56
20514237-4	2009	This phenotype is restricted to the cotyledons, and growth of the hypocotyl and roots of the cho1 mutants is inhibited by excess nitrate.	Nitrates	129-136	AINTEGUMENTA-like 5	Arabidopsis thaliana	93-97
20514237-6	2009	Altered nitrate distribution and storage may explain the phenotypes of the cho1 mutants.	Nitrates	8-15	AINTEGUMENTA-like 5	Arabidopsis thaliana	75-79
19732351-7	2009	A similar upregulation and downregulation of AtNRT1.1 and AtNRT2.1 was observed by ethylene synthesis precursor aminocyclopropane carboxylic acid (ACC) and AVG in low and high nitrate concentration, respectively.	Nitrates	176-183	nitrate transporter 1.1	Arabidopsis thaliana	45-53
19732351-7	2009	A similar upregulation and downregulation of AtNRT1.1 and AtNRT2.1 was observed by ethylene synthesis precursor aminocyclopropane carboxylic acid (ACC) and AVG in low and high nitrate concentration, respectively.	Nitrates	176-183	nitrate transporter 2:1	Arabidopsis thaliana	58-66
19785658-12	2009	AFP also increased H(2)O(2) and modulated nitrite/nitrate levels in non-stimulated keratinocytes whereas it did not affect these parameters or cytokine release from UVA-stimulated cells.	Nitrates	50-57	alpha fetoprotein	Homo sapiens	0-3
19885533-1	2009	Our research group previously reported a two-dimensional cationic inorganic material (BING-5, Pb(3)F(5)NO(3)) where nitrate resides in the interlamellar space and can be anion exchanged.	Nitrates	116-123	D6S2723E	Homo sapiens	86-92
19943390-6	2009	Nitrate (NO3-) leaching increased only from the catchment without a forest buffer.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
19544384-1	2009	Halophilic (salt loving), hydrogenotrophic (H(2) oxidizing) denitrifying bacteria were investigated for treatment of nitrate (NO3-) and perchlorate (ClO4-) contaminated groundwater and ion exchange (IX) brines.	Nitrates	117-124	NBL1, DAN family BMP antagonist	Homo sapiens	126-129
19845487-10	2009	The cells were then exposed to Escherichia coli endotoxin to determine if increased intracellular penetration of catalase would inhibit H(2)O(2), nitrate, and cytokine synthesis.	Nitrates	146-153	catalase	Homo sapiens	113-121
19681094-7	2009	Analysis of iNOS protein and the associated formation of nitrites and lipid peroxidation products was performed using immunoblotting and biochemical analysis, and revealed increases in iNOS protein, nitrate levels and oxidative stress at day 1 following ionizing irradiation.	Nitrates	199-206	nitric oxide synthase 2, inducible	Mus musculus	12-16
19911129-3	2009	Furthermore, ALDH2 catalyzes nitroglycerin to nitrate and 1, 2-glyceryldinitrate during therapy for angina pectoris, myocardial infarction, and heart failure.	Nitrates	46-53	aldehyde dehydrogenase 2 family member	Homo sapiens	13-18
19636075-0	2009	ATP binding to the C terminus of the Arabidopsis thaliana nitrate/proton antiporter, AtCLCa, regulates nitrate transport into plant vacuoles.	Nitrates	58-65	chloride channel A	Arabidopsis thaliana	85-91
19650765-2	2009	Also, Mb plays a role in regulating *NO (nitric oxide) homoeostasis through (i) binding *NO (Mb-NO complex); (ii) oxidation of *NO to nitrate; and (iii) formation of vasoactive S-nitroso-Mb [Rayner, B.S., Wu, B.-J., Raftery, M., Stocker, R. and Witting, P.K.	Nitrates	134-141	myoglobin	Rattus norvegicus	6-8
19636075-2	2009	Nitrate accumulation within the vacuole is primarily mediated by the NO(3)(-)/H(+) exchanger AtCLCa, which belongs to the chloride channel (CLC) family.	Nitrates	0-7	chloride channel A	Arabidopsis thaliana	93-99
19766561-3	2009	(2009) show that phosphorylation of the CHL1 nitrate transporter allows the plant root to sense and respond to different nitrate concentrations in the soil.	Nitrates	45-52	cell adhesion molecule L1 like	Homo sapiens	40-44
19586916-6	2009	Moreover, we show that Fdx2 (Em = -321 mV), whose expression is regulated by nitrate, is a more efficient electron donor to nitrite reductase relative to Fd.	Nitrates	77-84	ferredoxin 2	Homo sapiens	23-27
19586916-6	2009	Moreover, we show that Fdx2 (Em = -321 mV), whose expression is regulated by nitrate, is a more efficient electron donor to nitrite reductase relative to Fd.	Nitrates	77-84	uncharacterized protein	Chlamydomonas reinhardtii	124-141
19733718-6	2009	The concentrations of plasma endothelin-1, a potent vasoconstrictor peptide produced by vascular endothelial cells, significantly decreased and plasma nitric oxide (measured as the stable end product [nitrite/nitrate]), a potent vasodilator produced by vascular endothelial cells, significantly increased after the weight-reduction exercise program.	Nitrates	209-216	endothelin 1	Homo sapiens	29-41
19785274-7	2009	International emissions are an additional uncontrollable and significant contribution to total sulfate (SO4) and nitrate (NO3) concentrations at the western Class I areas.	Nitrates	113-120	NBL1, DAN family BMP antagonist	Homo sapiens	122-125
19563531-11	2009	CONCLUSIONS AND IMPLICATIONS: The present results demonstrate that not all high potency nitrates are bioactivated by ALDH-2 and that high potency of a given nitrate is not necessarily associated with induction of oxidative stress or nitrate tolerance.	Nitrates	88-96	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	117-123
19563531-12	2009	Obviously, there are distinct pathways for bioactivation of organic nitrates, which for AEN may involve xanthine oxidoreductase rather than P450 enzymes.	Nitrates	68-76	xanthine dehydrogenase	Mus musculus	104-127
19764219-2	2009	While nitrate (NO3-) reduction is energetically favored over sulfate reduction, the influence of NO3 on the accumulation of CH3Hg+ has not been reported in the literature.	Nitrates	6-13	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
19882863-9	2009	The content of nitrates was estimated as a difference between the total level of nitro compounds and the content of RNO2.	Nitrates	15-23	NLR family pyrin domain containing 12	Homo sapiens	116-120
19809847-5	2009	Our results showed, when compared with control aliquots, that the presence of fibrinogen modulates the NO mobilization in erythrocytes by (1) decreasing erythrocyte NO efflux levels (P &lt; 0.001); (2) increasing levels of intraerythrocytic NO oxidative metabolites, namely, nitrite (P &lt; 0.0001) and nitrate (P &lt; 0.0001); and (3) enhancing the formation of GSNO (P &lt; 0.001).	Nitrates	303-310	fibrinogen beta chain	Homo sapiens	78-88
19734434-0	2009	The Arabidopsis nitrate transporter NRT1.7, expressed in phloem, is responsible for source-to-sink remobilization of nitrate.	Nitrates	16-23	nitrate transporter 1.1	Arabidopsis thaliana	36-40
19633234-0	2009	A genetic screen for nitrate regulatory mutants captures the nitrate transporter gene NRT1.1.	Nitrates	21-28	nitrate transporter 1.1	Arabidopsis thaliana	86-92
19633234-2	2009	A mutation was identified that impaired nitrate induction, and it was localized to the nitrate regulatory gene NLP7, demonstrating the validity of this screen.	Nitrates	40-47	NIN like protein 7	Arabidopsis thaliana	111-115
19633234-2	2009	A mutation was identified that impaired nitrate induction, and it was localized to the nitrate regulatory gene NLP7, demonstrating the validity of this screen.	Nitrates	87-94	NIN like protein 7	Arabidopsis thaliana	111-115
19633234-5	2009	The nrg1 mutation disrupted nitrate regulation of several endogenous genes as induction of three nitrate-responsive genes (NIA1, NiR, and NRT2.1) was dramatically reduced in roots of the mutant after 2-h treatment using nitrate concentrations from 0.25 to 20 mm.	Nitrates	97-104	nitrate reductase 1	Arabidopsis thaliana	123-127
19633234-5	2009	The nrg1 mutation disrupted nitrate regulation of several endogenous genes as induction of three nitrate-responsive genes (NIA1, NiR, and NRT2.1) was dramatically reduced in roots of the mutant after 2-h treatment using nitrate concentrations from 0.25 to 20 mm.	Nitrates	97-104	nitrate reductase 1	Arabidopsis thaliana	123-127
19633234-7	2009	The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation.	Nitrates	12-19	nitrate transporter 1.1	Arabidopsis thaliana	41-47
19633234-7	2009	The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation.	Nitrates	12-19	nitrate transporter 1.1	Arabidopsis thaliana	66-72
19633234-7	2009	The loss of nitrate induction in the two nrt1.1 mutants (nrg1 and chl1-5) was not explained by reduced nitrate uptake and was reversed by nitrogen deprivation.	Nitrates	103-110	nitrate transporter 1.1	Arabidopsis thaliana	41-47
19633234-10	2009	These results strongly support the model that NRT1.1 acts as a nitrate regulator or sensor in Arabidopsis.	Nitrates	63-70	nitrate transporter 1.1	Arabidopsis thaliana	46-52
19734434-2	2009	This study of the Arabidopsis thaliana nitrate transporter NRT1.7 provides new insights into nitrate remobilization.	Nitrates	39-46	nitrate transporter 1.1	Arabidopsis thaliana	59-63
19734434-4	2009	In nrt1.7 mutants, more nitrate was present in the older leaves, less (15)NO(3)(-) spotted on old leaves was remobilized into N-demanding tissues, and less nitrate was detected in the phloem exudates of old leaves.	Nitrates	24-31	nitrate transporter 1.1	Arabidopsis thaliana	3-7
19734434-4	2009	In nrt1.7 mutants, more nitrate was present in the older leaves, less (15)NO(3)(-) spotted on old leaves was remobilized into N-demanding tissues, and less nitrate was detected in the phloem exudates of old leaves.	Nitrates	156-163	nitrate transporter 1.1	Arabidopsis thaliana	3-7
19734434-5	2009	These data indicate that NRT1.7 is responsible for phloem loading of nitrate in the source leaf to allow nitrate transport out of older leaves and into younger leaves.	Nitrates	69-76	nitrate transporter 1.1	Arabidopsis thaliana	25-29
19734434-5	2009	These data indicate that NRT1.7 is responsible for phloem loading of nitrate in the source leaf to allow nitrate transport out of older leaves and into younger leaves.	Nitrates	105-112	nitrate transporter 1.1	Arabidopsis thaliana	25-29
19698183-10	2009	Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively.	Nitrates	108-115	linoleate 13S-lipoxygenase10	Zea mays	33-48
19698183-10	2009	Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively.	Nitrates	108-115	MLO-like protein 4	Zea mays	313-344
19698183-10	2009	Moreover, the up-accumulation of lipoxygenase 10 indicated that the leaf response to a high availability of nitrate may also involve a modification in lipid metabolism.Finally, this proteomic approach suggested that the nutritional status of the plant may affect two different post-translational modifications of phosphoenolpyruvate carboxylase (PEPCase) consisting in monoubiquitination and phosphorylation in roots and leaves, respectively.	Nitrates	108-115	MLO-like protein 4	Zea mays	346-353
18830972-8	2009	We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS).	Nitrates	31-38	nitric oxide synthase 2	Homo sapiens	92-123
18830972-8	2009	We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS).	Nitrates	31-38	nitric oxide synthase 2	Homo sapiens	125-129
18830972-8	2009	We confirmed that reduction of Nitrate levels in Jurkat cells was due to down-regulation of inducible nitric oxide synthase (iNOS), not endothelial nitric oxide synthase (eNOS).	Nitrates	31-38	nitric oxide synthase 3	Homo sapiens	136-169
19376780-1	2009	BACKGROUND AND AIMS: Nitric oxide (NO) has been demonstrated to stimulate the activity of nitrate reductase (NR) in plant roots supplied with a low level of nitrate, and to affect proteins differently, depending on the ratio of NO to the level of protein.	Nitrates	90-97	nitrate reductase [NADH]	Solanum lycopersicum	109-111
19577274-2	2009	Total nitrogen removal efficiencies were 73-80% and 70-77% for the NMBR and UMBR, respectively, with 1-1.7 mgL(-1) lower effluent nitrates in the NMBR.	Nitrates	130-138	LLGL scribble cell polarity complex component 1	Homo sapiens	107-113
19376780-8	2009	Nevertheless, a low rate of NO gas increased while cPTIO decreased the NR activities of the enzyme extracts from the roots at both nitrate levels.	Nitrates	131-138	nitrate reductase [NADH]	Solanum lycopersicum	71-73
19376780-9	2009	Increasing the rate of NO gas further increased NR activity in the enzyme extracts of the roots fed with 0.5 mM nitrate but decreased it when 5 mM nitrate was supplied.	Nitrates	112-119	nitrate reductase [NADH]	Solanum lycopersicum	48-50
19376780-10	2009	Interestingly, the stimulative effect of NO gas on NR activity could be reversed by NO removal through N(2) flushing in the enzyme extracts from the roots fed with 0.5 mM nitrate but not from those with 5 mM nitrate.	Nitrates	171-178	nitrate reductase [NADH]	Solanum lycopersicum	51-53
19376780-10	2009	Interestingly, the stimulative effect of NO gas on NR activity could be reversed by NO removal through N(2) flushing in the enzyme extracts from the roots fed with 0.5 mM nitrate but not from those with 5 mM nitrate.	Nitrates	208-215	nitrate reductase [NADH]	Solanum lycopersicum	51-53
19376780-11	2009	CONCLUSIONS: The effects of NO on NR activity in tomato roots depend on levels of nitrate supply, and probably result from direct interactions between NO and NR protein.	Nitrates	82-89	nitrate reductase [NADH]	Solanum lycopersicum	34-36
19346443-6	2009	Mechanistic studies in rats identified oxidative stress, ALDH-2 inactivation, and vascular dysfunction as common features in acute and chronic nitrate tolerance.	Nitrates	143-150	aldehyde dehydrogenase 2 family member	Rattus norvegicus	57-63
19376780-11	2009	CONCLUSIONS: The effects of NO on NR activity in tomato roots depend on levels of nitrate supply, and probably result from direct interactions between NO and NR protein.	Nitrates	82-89	nitrate reductase [NADH]	Solanum lycopersicum	158-160
19662837-1	2009	A dual isotope method of measuring both the delta 15N and delta 18O in NO3- was used to discriminate the origin of nitrate and its denitrification in groundwater in Shijiazhuang.	Nitrates	115-122	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
19346117-4	2009	The mechanisms involved are related to: i) the reduced sensitivity to insulin and other substances acting via intracellular cyclic nucleotides, such as nitrates and prostacyclin; ii) the altered intracellular ionic milieu with elevated cytosolic Ca(2+); and iii) the increased oxidative stress, which elicits isoprostane production from arachidonic acid.	Nitrates	152-160	insulin	Homo sapiens	70-77
20005475-3	2009	In addition, chronic nitrate treatment results in ALDH2 inhibition and contributes to nitrate tolerance.	Nitrates	21-28	aldehyde dehydrogenase 2 family member	Homo sapiens	50-55
19042082-4	2009	LDH samples containing nitrate ions with parallel (LDH5) and perpendicular (LDH3) orientations exhibited different 2,4-D adsorption characteristics under competition with co-existing anions for surface binding sites.	Nitrates	23-30	lactate dehydrogenase C	Homo sapiens	0-3
19042082-4	2009	LDH samples containing nitrate ions with parallel (LDH5) and perpendicular (LDH3) orientations exhibited different 2,4-D adsorption characteristics under competition with co-existing anions for surface binding sites.	Nitrates	23-30	lactate dehydrogenase C	Homo sapiens	76-80
19042082-6	2009	On the contrary, the interlayer nitrate in LDH3 is readily exchanged by 2,4-D.	Nitrates	32-39	lactate dehydrogenase C	Homo sapiens	43-47
19662837-3	2009	The results show that the ratio of delta 15N/delta 18O in NO3- is close to 2:1, indicating that some denitrification is occurring in this area; The value of delta 15N and delta 18O in NO3- after denitrification are 4.6 per thousand-13.9 per thousand and 1.9 per thousand-7.8 per thousand respectively, which indicates that the main source of nitrate in groundwater are local fertilizer and Animal Waste/Septic Systems.	Nitrates	342-349	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
19662837-3	2009	The results show that the ratio of delta 15N/delta 18O in NO3- is close to 2:1, indicating that some denitrification is occurring in this area; The value of delta 15N and delta 18O in NO3- after denitrification are 4.6 per thousand-13.9 per thousand and 1.9 per thousand-7.8 per thousand respectively, which indicates that the main source of nitrate in groundwater are local fertilizer and Animal Waste/Septic Systems.	Nitrates	342-349	NBL1, DAN family BMP antagonist	Homo sapiens	184-187
19500399-2	2009	Herein, a systems biology approach was developed to identify the components and role of cross-talk between nitrate and hormone signals, likely to be involved in the conditional response of NO3- signaling.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	189-192
19346351-9	2009	Besides a menaquinone source, isogenic mutants revealed that cydA and ndh1 are required for the aerobic-respiration-like response and narG for nitrate reduction.	Nitrates	143-150	NAD(P)/FAD-dependent oxidoreductase	Lactobacillus plantarum WCFS1	70-74
19346351-10	2009	The ndh1 mutant was still able to reduce nitrate.	Nitrates	41-48	NAD(P)/FAD-dependent oxidoreductase	Lactobacillus plantarum WCFS1	4-8
19493694-1	2009	Deficiency of mineral nutrients such as nitrate, phosphate, potassium and sulphate strongly affects the type and amount of metabolites produced by crops with knock-on effects on nutritional quality of the crop, its processing properties and disease resistance.	Nitrates	40-47	LUC7 like 3 pre-mRNA splicing factor	Homo sapiens	147-151
19460002-8	2009	RESULTS: Application of LPS to the pulp increased NOS activity and nitrate production (P &lt; 0.001), generated by iNOS over-activity and expression.	Nitrates	67-74	nitric oxide synthase 2	Rattus norvegicus	115-119
19223666-2	2009	In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased protein [(35)S]cysteine incorporation, significant S-glutathionylation of multiple proteins, and decreased metabolic activity of several SH-sensitive enzymes, including creatine kinase, xanthine oxidoreductase, and glutaredoxin (GRX).	Nitrates	32-39	glutaredoxin-1	Sus scrofa	341-353
19534114-6	2009	The peak intensities of nitrate during the nighttime and high concentrations of O3 and NO2 strongly suggest that the heterogeneous reactions of N2O5 and NO3 onthe aerosol surface dominated the particulate nitrate formation on polluted days.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
19534114-6	2009	The peak intensities of nitrate during the nighttime and high concentrations of O3 and NO2 strongly suggest that the heterogeneous reactions of N2O5 and NO3 onthe aerosol surface dominated the particulate nitrate formation on polluted days.	Nitrates	205-212	NBL1, DAN family BMP antagonist	Homo sapiens	153-156
19201616-1	2009	Anionic group II metal nitrate clusters of the formula [M(2)(NO(3))(5)](-), where M(2) = Mg(2), MgCa, Ca(2), and Sr(2), are investigated by infrared multiple photon dissociation (IRMPD) spectroscopy to obtain vibrational spectra in the mid-IR region.	Nitrates	23-30	attractin	Homo sapiens	96-100
19223666-2	2009	In LLC-PK1 cells, we found that nitrate tolerance, as indicated by cGMP accumulation toward NTG, was accompanied by increased protein [(35)S]cysteine incorporation, significant S-glutathionylation of multiple proteins, and decreased metabolic activity of several SH-sensitive enzymes, including creatine kinase, xanthine oxidoreductase, and glutaredoxin (GRX).	Nitrates	32-39	glutaredoxin-1	Sus scrofa	355-358
19261613-12	2009	When inserted into the model Torpedo chloride channel ClC-0, the equivalent mutation increased nitrate relative to chloride conductance.	Nitrates	95-102	Charcot-Leyden crystal galectin	Homo sapiens	54-57
19261613-0	2009	Residues important for nitrate/proton coupling in plant and mammalian CLC transporters.	Nitrates	23-30	Charcot-Leyden crystal galectin	Homo sapiens	70-73
19325986-10	2009	STM shows that the morphology of the particle system is largely conserved during NO(2) exposure at 300 K. The reaction is limited to the formation of surface nitrites and nitrates, which are characterized by low thermal stability and completely decompose below 500 K. As no further sintering occurs before decomposition, NO(2) uptake and release is a fully reversible process.	Nitrates	171-179	sulfotransferase family 1A member 3	Homo sapiens	0-3
19326931-4	2009	In the 1:3 nitrate complex, the one independent silver atom major component (0.78(1)) is closely trigonal planar AgS3 (Ag-S 2.518(2)-2.592(1) A, Sigma(S-Ag-S) 359.7(0) degrees); there are minor nearby components (0.11(1)) which may be regarded as four-coordinate, forming a putative one-dimensional polymer.	Nitrates	11-18	G protein signaling modulator 1	Homo sapiens	113-117
19254277-13	2009	CONCLUSIONS AND IMPLICATIONS: These results indicate that nitrate tolerance is associated with ALDH2 inactivation, whereas ascorbate deficiency possibly results in down-regulation of ALDH2 expression.	Nitrates	58-65	aldehyde dehydrogenase, mitochondrial	Cavia porcellus	95-100
19147491-4	2009	Stable expression of small hairpin RNA targeting cytoglobin in fibroblasts resulted in decreased NO consumption and intracellular nitrate production.	Nitrates	130-137	cytoglobin	Homo sapiens	49-59
18716872-4	2009	Furthermore, NAC plus 5-ASA reduced nitrate generation, an expression of inducible nitric oxide synthase (iNOS) activity, to basal levels and these results were significantly lower than those observed with either NAC or 5-ASA alone.	Nitrates	36-43	nitric oxide synthase 2	Rattus norvegicus	73-104
18716872-4	2009	Furthermore, NAC plus 5-ASA reduced nitrate generation, an expression of inducible nitric oxide synthase (iNOS) activity, to basal levels and these results were significantly lower than those observed with either NAC or 5-ASA alone.	Nitrates	36-43	nitric oxide synthase 2	Rattus norvegicus	106-110
18379890-12	2009	Diurnal variation of Sulfur-dioxide and Nitrogen dioxide were found to have inverse relationship with visibility during fog which may be due to formation of secondary pollutants such as sulfate and to a lesser extent nitrates.	Nitrates	217-225	zinc finger protein, FOG family member 1	Homo sapiens	120-123
23572923-0	2009	Genomewide bioinformatic analysis negates any specific role for Dof, GATA and Ag/cTCA motifs in nitrate responsive gene expression in Arabidopsis.	Nitrates	96-103	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	69-73
19054349-3	2009	Transgenic seedlings constitutively over-expressing STP13 (STP13OX) had increased rates of glucose uptake, higher endogenous sucrose levels and accumulated more total C and biomass per plant when grown on soil-less media supplemented with 55 mM glucose and sufficient N (9 mM nitrate).	Nitrates	276-283	Major facilitator superfamily protein	Arabidopsis thaliana	52-57
18834868-0	2009	Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment.	Nitrates	71-78	aldehyde dehydrogenase 2 family member	Homo sapiens	38-44
19378654-4	2009	The highest denitrification rate of 0.203kg/(m3 x d) was achieved when flow rate and nitrate concentration were 153 L/d and 25.3 mgN/L, respectively.	Nitrates	85-92	helt bHLH transcription factor	Homo sapiens	129-132
19054349-3	2009	Transgenic seedlings constitutively over-expressing STP13 (STP13OX) had increased rates of glucose uptake, higher endogenous sucrose levels and accumulated more total C and biomass per plant when grown on soil-less media supplemented with 55 mM glucose and sufficient N (9 mM nitrate).	Nitrates	276-283	Major facilitator superfamily protein	Arabidopsis thaliana	59-66
19054349-5	2009	In addition, STP13OX seedlings were larger and had higher biomass than Col-0 seedlings when grown under a limiting N condition (3 mM nitrate).	Nitrates	133-140	Major facilitator superfamily protein	Arabidopsis thaliana	13-20
18996902-6	2009	Compared with wild-type, bronchoalveolar lavage fluid (BALF) levels of nitrite plus nitrate, GM-CSF, and MCP-1, but not TNF-alpha and IFN-gamma, were higher in SP-D-deficient mice before and after HSCT.	Nitrates	84-91	surfactant associated protein D	Mus musculus	160-164
19060147-10	2009	The results suggest that the Fnr and Crp proteins may act synergistically to enhance NapABC synthesis during growth with poor carbon sources to help obtain energy from low levels of nitrate.	Nitrates	182-189	catabolite gene activator protein	Escherichia coli	37-40
18826430-3	2009	Although the Arabidopsis ANR1 transcription factor appears to control stimulation of lateral root elongation in response to nitrate, no regulators of nitrate assimilation have so far been identified in higher plants.	Nitrates	124-131	AGAMOUS-like 44	Arabidopsis thaliana	25-29
18618322-5	2009	Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc.	Nitrates	137-144	carbonic anhydrase 1	Homo sapiens	42-47
18618322-5	2009	Inhibition data of the cytosolic isozymes hCA I - hCA III with a large number of anions (halides, pseudohalides, bicarbonate, carbonate, nitrate, nitrite, hydrosulfide, sulfate, sulfamic acid, sulfamide, etc.	Nitrates	137-144	HCA1	Homo sapiens	42-45
19008412-5	2009	In support of the beneficial effects of pcDNA3.1-eNOS treatment being because of enhanced eNOS expression and activity, increased eNOS protein levels were documented in aorta, liver, kidney, and heart of fructose-treated rats injected with pcDNA3.1-eNOS, and corresponding elevations in nitrite/nitrate and cGMP concentrations were observed in urine.	Nitrates	295-302	nitric oxide synthase 3	Rattus norvegicus	49-53
19074630-0	2009	The Arabidopsis abscisic acid catabolic gene CYP707A2 plays a key role in nitrate control of seed dormancy.	Nitrates	74-81	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	45-53
19074630-5	2009	Profiling experiments indicated that the expression of the ABA catabolic gene CYP707A2 was regulated by exogenous nitrate.	Nitrates	114-121	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	78-86
19074630-7	2009	In contrast, both endogenous and exogenous nitrate reduced ABA levels of the wild-type and cyp707a1-1 mutant seeds.	Nitrates	43-50	cytochrome P450, family 707, subfamily A, polypeptide 1	Arabidopsis thaliana	91-99
19074630-8	2009	The CYP707A2 mRNA levels in developing siliques were positively correlated with different nitrate doses applied to the mother plants.	Nitrates	90-97	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	4-12
19074630-9	2009	This was consistent with a role of the CYP707A2 gene in controlling seed ABA levels in response to endogenous nitrate.	Nitrates	110-117	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	39-47
19074630-10	2009	The cyp707a2-1 mutant was less sensitive to exogenous nitrate for breaking seed dormancy.	Nitrates	54-61	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	4-12
19074630-11	2009	Altogether, our data underline the central role of the CYP707A2 gene in the nitrate-mediated control of ABA levels during seed development and germination.	Nitrates	76-83	cytochrome P450, family 707, subfamily A, polypeptide 2	Arabidopsis thaliana	55-63
19109301-0	2009	CHOTTO1, a double AP2 domain protein of Arabidopsis thaliana, regulates germination and seedling growth under excess supply of glucose and nitrate.	Nitrates	139-146	AINTEGUMENTA-like 5	Arabidopsis thaliana	0-7
19109301-11	2009	In addition, growth of cho1 mutant seedlings was partially resistant to excess nitrate (50 mM), as evident from their expanded green cotyledons.	Nitrates	79-86	AINTEGUMENTA-like 5	Arabidopsis thaliana	23-27
19109301-13	2009	This nitrate response was specific to the cho1 mutants and was not observed in the abi4 mutants.	Nitrates	5-12	AINTEGUMENTA-like 5	Arabidopsis thaliana	42-46
18826430-5	2009	Recently, the algal homologue NIT2 was found to regulate nitrate assimilation.	Nitrates	57-64	nitrilase 2	Arabidopsis thaliana	30-34
18826430-7	2009	We show that nlp7 mutants are impaired in transduction of the nitrate signal, and that the NLP7 expression pattern is consistent with a function of NLP7 in the sensing of nitrogen.	Nitrates	62-69	NIN like protein 7	Arabidopsis thaliana	13-17
18826430-9	2009	We propose NLP7 as an important element of the nitrate signal transduction pathway and as a new regulatory protein specific for nitrogen assimilation in non-nodulating plants.	Nitrates	47-54	NIN like protein 7	Arabidopsis thaliana	11-15
18791203-2	2009	Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction.	Nitrates	275-283	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	14-33
19164562-2	2009	Infection of Rag2(-/-) mice with Helicobacter hepaticus led to accumulation of macrophages and neutrophils in the colon, a process temporally related to up-regulation of tissue inducible nitric oxide synthase (iNOS) expression at the site of infection and increased nitric oxide (NO) production, as evidenced by urinary excretion of nitrate.	Nitrates	333-340	recombination activating gene 2	Mus musculus	13-17
19936118-0	2009	Is There Any Correlation between Insulin Resistance and Nitrate Plasma Concentration in White Coat Hypertensive Patients?	Nitrates	56-63	insulin	Homo sapiens	33-40
18791203-2	2009	Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction.	Nitrates	275-283	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	35-39
18791203-8	2009	CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation.	Nitrates	152-160	interferon gamma	Mus musculus	18-27
18791203-8	2009	CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation.	Nitrates	152-160	nitric oxide synthase 2, inducible	Mus musculus	68-72
18791203-2	2009	Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction.	Nitrates	275-283	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	148-153
18791203-8	2009	CONCLUSION: LPS + IFN gamma stimulates endothelial cells to produce iNOS-derived NO and NADPH oxidase-derived superoxide, which form peroxynitrite that nitrates tyrosine residues in PP2Ac and inhibits their phosphorylation.	Nitrates	152-160	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	Mus musculus	182-187
18791203-2	2009	Since protein phosphatase type 2A (PP2A) can mediate paracellular leak and can be inactivated by tyrosine phosphorylation in its catalytic subunit (PP2Ac), we hypothesized that microvascular endothelial cells exposed to proinflammatory stimulation produce peroxynitrite that nitrates PP2Ac, and this nitration inhibits tyrosine phosphorylation of PP2Ac and thereby increases PP2A activity to mediate endothelial barrier dysfunction.	Nitrates	275-283	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	148-152
19001185-13	2009	However, in mice lacking iNOS, maximum and minimum dP/dt, as well as an indicator of isovolumic contraction, markedly increased in response to isoproterenol, associated with decreased cardiac 4-hydroxy-2-nonenal expression and urinary nitrate/nitrite.	Nitrates	235-242	nitric oxide synthase 2, inducible	Mus musculus	25-29
19089335-5	2009	To overcome these obstacles of nitrate therapy, direct NO- and haem-independent sGC activators have been developed, such as BAY 58-2667 (cinaciguat) and HMR1766 (ataciguat), showing unique biochemical and pharmacological properties.	Nitrates	31-38	sarcoglycan beta	Homo sapiens	80-83
19307691-6	2009	Recent studies have revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role in the development of nitrate and cross-tolerance.	Nitrates	131-138	aldehyde dehydrogenase 2 family member	Homo sapiens	192-198
19330637-2	2009	Lead, cadmium, nickel, chromium, and nitrate (NO3-) concentrations in greenhouse cucumber (Cucumis sativa L.) and bell pepper (Capsicum annuum L.) and their dietary intakes were determined.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
19307691-7	2009	The present review focus first on the role of oxidative stress and second on the role of ALDH-2 in organic nitrate bioactivation leading to the development of tolerance and cross-tolerance (endothelial dysfunction) in response to nitroglycerin treatment.	Nitrates	107-114	aldehyde dehydrogenase 2 family member	Homo sapiens	89-95
19307691-8	2009	Recently, the role of mitochondrial oxidative stress in the development of nitrate tolerance was demonstrated in a mouse model with a heterozygous deletion of manganese superoxide dismutase (MnSOD(+/-)), which is the mitochondrial isoform of this enzyme.	Nitrates	75-82	superoxide dismutase 2, mitochondrial	Mus musculus	159-189
19307691-8	2009	Recently, the role of mitochondrial oxidative stress in the development of nitrate tolerance was demonstrated in a mouse model with a heterozygous deletion of manganese superoxide dismutase (MnSOD(+/-)), which is the mitochondrial isoform of this enzyme.	Nitrates	75-82	superoxide dismutase 2, mitochondrial	Mus musculus	191-196
18798873-0	2009	AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response.	Nitrates	91-98	Cbl proto-oncogene	Homo sapiens	11-14
18798873-0	2009	AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response.	Nitrates	91-98	CBL-interacting protein kinase 8	Arabidopsis thaliana	0-7
18798873-4	2009	In this study, a calcineurin B-like (CBL) -interacting protein kinase (CIPK) gene, CIPK8, was found to be involved in early nitrate signaling.	Nitrates	124-131	Cbl proto-oncogene	Homo sapiens	37-40
18798873-4	2009	In this study, a calcineurin B-like (CBL) -interacting protein kinase (CIPK) gene, CIPK8, was found to be involved in early nitrate signaling.	Nitrates	124-131	CBL-interacting protein kinase 8	Arabidopsis thaliana	83-88
18798873-5	2009	CIPK8 expression was rapidly induced by nitrate.	Nitrates	40-47	CBL-interacting protein kinase 8	Arabidopsis thaliana	0-5
18798873-6	2009	Analysis of two independent knockout mutants and a complemented line showed that CIPK8 positively regulates the nitrate-induced expression of primary nitrate response genes, including nitrate transporter genes and genes required for assimilation.	Nitrates	112-119	CBL-interacting protein kinase 8	Arabidopsis thaliana	81-86
18798873-6	2009	Analysis of two independent knockout mutants and a complemented line showed that CIPK8 positively regulates the nitrate-induced expression of primary nitrate response genes, including nitrate transporter genes and genes required for assimilation.	Nitrates	150-157	CBL-interacting protein kinase 8	Arabidopsis thaliana	81-86
18798873-8	2009	As cipk8 mutants were defective mainly in the low-affinity response, the high-affinity and low-affinity nitrate signaling systems are proposed to be genetically distinct, with CIPK8 involved in the low-affinity system.	Nitrates	104-111	CBL-interacting protein kinase 8	Arabidopsis thaliana	3-8
18798873-9	2009	In addition, CIPK8 was found to be involved in long-term nitrate-modulated primary root growth and nitrate-modulated expression of a vacuolar malate transporter.	Nitrates	57-64	CBL-interacting protein kinase 8	Arabidopsis thaliana	13-18
18798873-9	2009	In addition, CIPK8 was found to be involved in long-term nitrate-modulated primary root growth and nitrate-modulated expression of a vacuolar malate transporter.	Nitrates	99-106	CBL-interacting protein kinase 8	Arabidopsis thaliana	13-18
18798873-10	2009	Taken together, our results indicate that CBL-CIPK networks are responsible not only for stress responses and potassium shortage, but also for nitrate sensing.	Nitrates	143-150	Cbl proto-oncogene	Homo sapiens	42-45
19053540-4	2008	In particular, the quantum yield (phi) of nitrite formation was measured and found to significantly decrease at high concentrations of nitrate for Ca(NO(3))(2).	Nitrates	135-142	glucose-6-phosphate isomerase	Homo sapiens	34-37
19074184-0	2009	Nod factor/nitrate-induced CLE genes that drive HAR1-mediated systemic regulation of nodulation.	Nitrates	11-18	CM0216.560.nc	Lotus japonicus	48-52
19074184-8	2009	Based on these findings, we propose a simple model for AUT and nitrate inhibition of nodulation mediated by LjCLE-RS1, -RS2 peptides and the HAR1 receptor-like kinase.	Nitrates	63-70	CM0216.560.nc	Lotus japonicus	141-145
19053540-5	2008	In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4).	Nitrates	100-107	glucose-6-phosphate isomerase	Homo sapiens	15-18
19053540-5	2008	In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4).	Nitrates	100-107	glucose-6-phosphate isomerase	Homo sapiens	247-250
19053540-5	2008	In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4).	Nitrates	234-241	glucose-6-phosphate isomerase	Homo sapiens	15-18
19053540-5	2008	In particular, phi for Ca(NO(3))(2) was found to have a maximum value of (7.8 +/- 0.1) x 10(-3) for nitrate ion solution concentrations near one molal, with the smallest quantum yield for the highest concentration solution above 14 m nitrate ion, phi = (2.3 +/- 2.0) x 10(-4).	Nitrates	234-241	glucose-6-phosphate isomerase	Homo sapiens	247-250
19759441-1	2009	During ultraviolet light (UV) disinfection, nitrate (NO3-) present in raw water may transform to nitrite (NO2-) that can cause serious human diseases.	Nitrates	44-51	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
18993072-2	2008	The protein encoded by the Nce103 gene of Saccharomyces cerevisiae, a beta-carbonic anhydrase (CA, EC 4.2.1.1) designated as scCA, has been cloned, purified, characterized kinetically, and investigated for its inhibition with a series simple, inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate, and some of its isosteric species.	Nitrates	324-331	carbonate dehydratase NCE103	Saccharomyces cerevisiae S288C	27-33
19759443-2	2009	Without catalysts and any additional buffer, the MFC produced electricity continuously and the power density reached 1.3 W/m3 at a loading rate of 1.6 kg COD/m3 d. Simultaneously, the COD and the nitrate removal rate were 1.4 kg COD/m3 d and 67 g NO3-N/m3 d, respectively.	Nitrates	196-203	NBL1, DAN family BMP antagonist	Homo sapiens	247-250
19759443-5	2009	At a high recirculation rate of 10 ml/min, the power density and the nitrate removal rate greatly increased to 34 W/m3 and 294 g NO3--N/m3 d, respectively.	Nitrates	69-76	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
18977227-2	2008	Here, three structural aspects of human-brain-type-creatine-kinase (hBB-CK) were identified by X-ray crystallography: the ligand-free-form at 2.2A; the ADP-Mg2+, nitrate, and creatine complex (transition-state-analogue complex; TSAC); and the ADP-Mg2+-complex at 2.0A.	Nitrates	162-169	hemoglobin subunit beta	Homo sapiens	68-71
19075471-5	2008	Calibration graphs with linearity in the range of 0.7 - 40 muM were obtained for both nitrite and nitrate.	Nitrates	98-105	latexin	Homo sapiens	59-62
18653264-1	2008	Nitrate (NO3-) is often observed in surface waters draining terrestrial ecosystems that remain strongly nitrogen (N) limited.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
19189756-7	2008	Nitrate (NO3-) existed in both the PM2.5 and PM10-2.5.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
19050168-0	2008	Characterization of the Arabidopsis nitrate transporter NRT1.6 reveals a role of nitrate in early embryo development.	Nitrates	36-43	nitrate transporter 1.1	Arabidopsis thaliana	56-60
19050168-1	2008	This study of the Arabidopsis thaliana nitrate transporter NRT1.6 indicated that nitrate is important for early embryo development.	Nitrates	39-46	nitrate transporter 1.1	Arabidopsis thaliana	59-63
19050168-3	2008	RT-PCR, in situ hybridization, and beta-glucuronidase reporter gene analysis showed that expression of NRT1.6 is only detectable in reproductive tissue (the vascular tissue of the silique and funiculus) and that expression increases immediately after pollination, suggesting that NRT1.6 is involved in delivering nitrate from maternal tissue to the developing embryo.	Nitrates	313-320	nitrate transporter 1.6	Arabidopsis thaliana	103-109
19050168-3	2008	RT-PCR, in situ hybridization, and beta-glucuronidase reporter gene analysis showed that expression of NRT1.6 is only detectable in reproductive tissue (the vascular tissue of the silique and funiculus) and that expression increases immediately after pollination, suggesting that NRT1.6 is involved in delivering nitrate from maternal tissue to the developing embryo.	Nitrates	313-320	nitrate transporter 1.1	Arabidopsis thaliana	103-107
19050168-4	2008	In nrt1.6 mutants, the amount of nitrate accumulated in mature seeds was reduced and the seed abortion rate increased.	Nitrates	33-40	nitrate transporter 1.1	Arabidopsis thaliana	3-7
19050168-6	2008	The phenotype of the nrt1.6 mutants revealed a novel role of nitrate in early embryo development.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	21-25
18786921-1	2008	Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance.	Nitrates	101-108	aldehyde dehydrogenase 2 family member	Homo sapiens	38-43
18786921-1	2008	Mitochondrial aldehyde dehydrogenase (ALDH2) may be involved in the biotransformation of glyceryl trinitrate (GTN), and the inactivation of ALDH2 by GTN may contribute to the phenomenon of nitrate tolerance.	Nitrates	101-108	aldehyde dehydrogenase 2 family member	Homo sapiens	140-145
18786921-13	2008	These observations are consistent with a significant role for irreversible inactivation of ALDH2 in the development of nitrate tolerance.	Nitrates	119-126	aldehyde dehydrogenase 2 family member	Homo sapiens	91-96
18824664-6	2008	The cGMP agonists 8-bromo-cGMP and C-type natriuretic peptide also stimulated DDAH-2 gene and protein expression levels and DDAH activity and increased the amount of nitrite/nitrate released into the culture supernatants.	Nitrates	174-181	natriuretic peptide C	Rattus norvegicus	35-61
18713738-6	2008	We found that, under nitrogen limitation, Ynt1 phosphorylation is essential for rapid induction of nitrate assimilation genes.	Nitrates	99-106	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	42-46
18462937-3	2008	The use of an inoculum previously acclimated to high nitrate concentrations led to complete denitrification in 6h (denitrification rate: 22.8mg NO3- -N/gVSSh), using methanol as carbon source for a COD/N ratio of 4 and for a content of calcium in the wastewater of 150mg/L.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Homo sapiens	144-147
18074235-1	2008	We made an inventory of nitrate (NO3-N) enrichment in surface and groundwater systems in the Hooghly district of India owing to intensive farming with high fertilizer doses as a function of quantity of fertilizers use, soil characteristics, types of crop grown, depth of groundwater sampling and also N-load in soil profiles.	Nitrates	24-31	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
19092986-12	2008	Contents of LTC(4) and nitrite/nitrate increased (p&lt;0.01) after the low dose of TNF.	Nitrates	31-38	tumor necrosis factor	Bos taurus	83-86
18983076-1	2008	Nitrate (NO3) profiles in semiarid unsaturated zones archive land use change (LUC) impacts on nitrogen (N) cycling with implications for agricultural N management and groundwater quality.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
18201926-3	2008	Compared with other C atoms, the chemical shifts of both C-1 and C-5 atoms in these two types of glycosides decrease relatively rapidly as molality of calcium nitrate increases, indicating that the nitrate ion attractions for these glycosides cause a relatively strong enhancing shielding effect of C-1 and C-5 atoms.	Nitrates	159-166	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	57-68
18563586-1	2008	CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	0-4
18701635-8	2008	Further analysis revealed that reduction of CBS activity during reperfusion was accompanied by an elevation of NO metabolites (nitrate and nitrite) in the kidney tissue.	Nitrates	127-134	cystathionine beta synthase	Rattus norvegicus	44-47
18946854-3	2008	Recent research has demonstrated that highly reactive nitrates, such as nitroglycerin (or glyceryl trinitrate) and pentaerthrityl tetranitrate (PETN) are bioactivated by aldehyde dehydrogenase 2 (ALDH-2), an enzyme located in mitochondria.	Nitrates	54-62	aldehyde dehydrogenase 2 family member	Homo sapiens	170-194
18946854-3	2008	Recent research has demonstrated that highly reactive nitrates, such as nitroglycerin (or glyceryl trinitrate) and pentaerthrityl tetranitrate (PETN) are bioactivated by aldehyde dehydrogenase 2 (ALDH-2), an enzyme located in mitochondria.	Nitrates	54-62	aldehyde dehydrogenase 2 family member	Homo sapiens	196-202
18959330-7	2008	We found that the Upper Snake had surprisingly high biotic demand relative to smaller streams in the same river network for both ammonium (NH4+) and nitrate (NO3-).	Nitrates	149-156	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
18155958-5	2008	RESULTS: In the exposed area, nitrate concentration was measured in 78 wells and ranged from 15.39 to 246.90mg/l as NO3-.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
18155958-10	2008	Mean MetHb was normal when the nitrate concentration in water was below 50mg/l as NO3-, and reached an abnormal level, when the nitrate concentration in water ranged between 50 and 90mg/l as NO3-.	Nitrates	31-38	hemoglobin subunit gamma 2	Homo sapiens	5-10
18155958-11	2008	This last level was statistically similar to mean MetHb at nitrate level above 90mg/l as NO3- (up to 246.9mg/l as NO3-).	Nitrates	59-66	hemoglobin subunit gamma 2	Homo sapiens	50-55
18155958-11	2008	This last level was statistically similar to mean MetHb at nitrate level above 90mg/l as NO3- (up to 246.9mg/l as NO3-).	Nitrates	59-66	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
18563586-1	2008	CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	6-14
18563586-1	2008	CHL1 (AtNRT1.1) is a dual-affinity nitrate transporter of Arabidopsis thaliana, in which phosphorylation at Thr 101 switches CHL1 from low to high nitrate affinity.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	125-129
18563586-2	2008	CHL1 expressed in a Hansenula polymorpha high-affinity nitrate-transporter deficient mutant (Deltaynt1) restores nitrate uptake and growth.	Nitrates	55-62	DNA helicase	Saccharomyces cerevisiae S288C	0-4
18563586-3	2008	These events take place at nitrate concentrations as low as 500 microM, suggesting that CHL1 has a high-affinity for nitrate in yeast.	Nitrates	27-34	DNA helicase	Saccharomyces cerevisiae S288C	88-92
18956101-6	2008	Molecular dynamics (MD) simulations show that as the Cl- : NO3- ratio increases, the nitrate ions are drawn closer to the interface due to the existence of a double layer of interfacial Cl- and subsurface Na+.	Nitrates	85-92	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
18563586-3	2008	These events take place at nitrate concentrations as low as 500 microM, suggesting that CHL1 has a high-affinity for nitrate in yeast.	Nitrates	117-124	DNA helicase	Saccharomyces cerevisiae S288C	88-92
18563586-4	2008	Accordingly, CHL1 expressed in H. polymorpha presents a K(m) for nitrate of about 125 microM.	Nitrates	65-72	DNA helicase	Saccharomyces cerevisiae S288C	13-17
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	15-22	DNA helicase	Saccharomyces cerevisiae S288C	28-32
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	15-22	DNA helicase	Saccharomyces cerevisiae S288C	80-84
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	15-22	DNA helicase	Saccharomyces cerevisiae S288C	80-84
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	130-137	DNA helicase	Saccharomyces cerevisiae S288C	28-32
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	130-137	DNA helicase	Saccharomyces cerevisiae S288C	80-84
18563586-5	2008	The absence of nitrate, the CHL1 gene inducer, showed the high turnover rate of CHL1 expressed in yeast, which is counteracted by nitrate CHL1 induction.	Nitrates	130-137	DNA helicase	Saccharomyces cerevisiae S288C	80-84
18563586-7	2008	Given that CHL1 presented high affinity by nitrate, we study the role of CHL1 Thr101 in yeast.	Nitrates	43-50	DNA helicase	Saccharomyces cerevisiae S288C	11-15
18563586-9	2008	Yeast strains expressing CHL1Thr101Ala, CHL1Thr101Asp and CHL1 at the same rate showed that Deltaynt1CHL1Thr101Ala is strikingly unable to transport nitrate and contains a very low amount of CHL1 protein; however, Deltaynt1CHL1Thr101Asp restores nitrate uptake and growth, although no significant changes in nitrate affinity were observed.	Nitrates	246-253	DNA helicase	Saccharomyces cerevisiae S288C	25-29
18563586-9	2008	Yeast strains expressing CHL1Thr101Ala, CHL1Thr101Asp and CHL1 at the same rate showed that Deltaynt1CHL1Thr101Ala is strikingly unable to transport nitrate and contains a very low amount of CHL1 protein; however, Deltaynt1CHL1Thr101Asp restores nitrate uptake and growth, although no significant changes in nitrate affinity were observed.	Nitrates	246-253	DNA helicase	Saccharomyces cerevisiae S288C	25-29
18563586-11	2008	The functional expression of CHL1 in H. polymorpha reveals that this yeast is a suitable tool for evaluating the real nitrate transport capacity of plant putative nitrate transporters belonging to different families and study their regulation and structure function relationship.	Nitrates	118-125	DNA helicase	Saccharomyces cerevisiae S288C	29-33
18563586-11	2008	The functional expression of CHL1 in H. polymorpha reveals that this yeast is a suitable tool for evaluating the real nitrate transport capacity of plant putative nitrate transporters belonging to different families and study their regulation and structure function relationship.	Nitrates	163-170	DNA helicase	Saccharomyces cerevisiae S288C	29-33
18685092-5	2008	Cardiac-specific eNOS overexpression resulted in significant increases in nitrite, nitrate, and nitrosothiols in the heart, plasma, and liver.	Nitrates	83-90	nitric oxide synthase 3, endothelial cell	Mus musculus	17-21
18572022-6	2008	Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate.	Nitrates	54-61	interferon regulatory factor 6	Homo sapiens	5-8
18572022-6	2008	Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate.	Nitrates	54-61	interferon gamma	Homo sapiens	13-22
18572022-6	2008	Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate.	Nitrates	54-61	nitric oxide synthase 2	Homo sapiens	30-34
18572022-6	2008	Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate.	Nitrates	182-189	interferon regulatory factor 6	Homo sapiens	5-8
18572022-6	2008	Both LPS and IFN-gamma induce iNOS with generation of nitrate up to 9 muM in the media after a 24-h stimulation, while native RAW 264.7 macrophages neither express iNOS nor generate nitrate.	Nitrates	182-189	interferon gamma	Homo sapiens	13-22
18394025-9	2008	RESULTS: Despite similar infarct size, deficiency in iNOS resulted in significantly lower plasma nitrate/nitrite levels, better haemodynamic performance and lower mortality 2 weeks after coronary ligation.	Nitrates	97-104	nitric oxide synthase 2, inducible	Mus musculus	53-57
18800519-1	2008	In the Rocky Mountains, there is uncertainty about the source areas and emission types that contribute to nitrate (NO3) deposition, which can adversely affect sensitive aquatic habitats of high-elevation watersheds.	Nitrates	106-113	NBL1, DAN family BMP antagonist	Homo sapiens	115-118
18780802-0	2008	Mutation of the Arabidopsis NRT1.5 nitrate transporter causes defective root-to-shoot nitrate transport.	Nitrates	35-42	nitrate transporter 1.1	Arabidopsis thaliana	28-32
18780802-2	2008	NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	0-4
18780802-2	2008	NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	65-69
18780802-2	2008	NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	125-131
18780802-2	2008	NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	133-137
18780802-2	2008	NRT1.5 is one of the 53 Arabidopsis thaliana nitrate transporter NRT1 (Peptide Transporter PTR) genes, of which two members, NRT1.1 (CHL1 for Chlorate resistant 1) and NRT1.2, have been shown to be involved in nitrate uptake.	Nitrates	45-52	nitrate transporter 1:2	Arabidopsis thaliana	168-174
18780802-5	2008	Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	35-39
18780802-5	2008	Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	128-132
18780802-5	2008	Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate.	Nitrates	173-180	nitrate transporter 1.1	Arabidopsis thaliana	35-39
18780802-5	2008	Knockdown or knockout mutations of NRT1.5 reduced the amount of nitrate transported from the root to the shoot, suggesting that NRT1.5 participates in root xylem loading of nitrate.	Nitrates	173-180	nitrate transporter 1.1	Arabidopsis thaliana	128-132
18780802-7	2008	These data suggest that, in addition to that involving NRT1.5, another mechanism is responsible for xylem loading of nitrate.	Nitrates	117-124	nitrate transporter 1.1	Arabidopsis thaliana	55-59
18780802-8	2008	Further analyses of the nrt1.5 mutants revealed a regulatory loop between nitrate and potassium at the xylem transport step.	Nitrates	74-81	nitrate transporter 1.1	Arabidopsis thaliana	24-28
18501719-6	2008	Mice deficient in endothelial nitric oxide synthase (eNOS-/-) demonstrated decreased blood and tissue nitrite, nitrate, and nitroso proteins, which were further reduced by low-nitrite (NOx) diet for 1 week.	Nitrates	111-118	nitric oxide synthase 3, endothelial cell	Mus musculus	18-51
18455513-7	2008	RESULTS: We found significant negative correlations between pro-MMP-9 levels and plasma nitrite (P=0.035, rs= -0.159), nitrate (P=0.040, rs= -0.158), and cGMP (P=0.011, rs= -0.189) concentrations.	Nitrates	119-126	matrix metallopeptidase 9	Homo sapiens	64-69
18522491-3	2008	Nitrate tolerance was induced by nitroglycerin infusion in male Wistar rats (100 microg/h/4 day) and in C57/Bl6, p47(phox/) and gp91(phox/) mice (50 microg/h/4 day).	Nitrates	0-7	NSFL1 cofactor	Rattus norvegicus	113-116
17462814-3	2008	The methodology is demonstrated by applying it separately to a set of general water quality indicators (total suspended solids, biochemical and chemical oxygen demand, nitrates, phosphates and faecal coliforms) to produce a ranked list of BMP pollutant removal efficiencies.	Nitrates	168-176	bone morphogenetic protein 1	Homo sapiens	239-242
18384503-4	2008	The subsequent return to a complete medium (containing nitrate) restored expression of all three AS genes.	Nitrates	55-62	asparagine synthetase	Glycine max	97-99
18384503-9	2008	It is concluded that nitrate (or one of its assimilatory products) leads to the induction of AS in roots of soybean and that this underlies the variations found in xylem sap Asn/Asp ratios.	Nitrates	21-28	asparagine synthetase	Glycine max	93-95
18367148-10	2008	RESULTS: APC treatment significantly reduced activities of oxidative enzymes and nitrate/nitrite levels in the lung tissues, and plasma levels of proinflammatory cytokines and D-dimer, and also significantly increased activities of antioxidative enzymes (P &lt; .05).	Nitrates	81-88	APC regulator of WNT signaling pathway	Rattus norvegicus	9-12
18594707-2	2008	Among two series of Ln(III) nitrate complexes (Ln = Pr, Nd, Sm, Eu, Gd, Tb or Dy) which have been characterized by elemental analyses, XRD, TGA and IR spectra, three new coordination polymers have been determined by X-ray diffraction analysis.	Nitrates	28-35	T-box transcription factor 1	Homo sapiens	140-143
18557906-1	2008	A full-length cDNA encoding a putative high-affinity nitrate transporter (ZmNrt2.2) from maize was isolated and characterised, together with another previously identified transporter (ZmNrt2.1), in terms of phylogenesis, protein structure prediction and regulation of transcript accumulation in response to nitrate and sugar availability.	Nitrates	53-60	putative high affinity nitrate transporter	Zea mays	74-82
18557906-3	2008	Data obtained suggested similar genetic evolution and identical transmembrane structure prediction between the two deduced proteins, and differences in both regulation of their expression and mRNA localisation in response to nitrate, leading us to hypothesise a principal role for ZmNRT2.1 in the influx activity and the major involvement of ZmNRT2.2 in the xylem loading process.	Nitrates	225-232	nitrate transport 2	Zea mays	281-289
18557906-4	2008	Our data suggest opposing sugar regulation by ZmNrt2.1 and ZmNrt2.2 transcription in the presence or absence of nitrate and the existence of both hexokinase-dependent and hexokinase-independent transduction mechanisms for the regulation of ZmNrt2.1 and ZmNrt2.2 expression by sugars.	Nitrates	112-119	nitrate transport 2	Zea mays	46-54
18557906-4	2008	Our data suggest opposing sugar regulation by ZmNrt2.1 and ZmNrt2.2 transcription in the presence or absence of nitrate and the existence of both hexokinase-dependent and hexokinase-independent transduction mechanisms for the regulation of ZmNrt2.1 and ZmNrt2.2 expression by sugars.	Nitrates	112-119	putative high affinity nitrate transporter	Zea mays	59-67
18499297-9	2008	Dissolved RDX samples were degraded in the laboratory and results showed that all reproduced degradation processes released nitrate with a strong fractionation.	Nitrates	124-131	radixin	Homo sapiens	10-13
18499297-10	2008	Laboratory isotopic values for RDX-derived NO(3)(-) produced a trend of high delta(18)O-low delta(15)N to low delta(18)O-high delta(15)N, and groundwater samples with nitrate concentrations above the expected background level appeared along this trend.	Nitrates	167-174	radixin	Homo sapiens	31-34
18499297-11	2008	Our results thus point toward a characteristic field of isotopic ratios for nitrate being derived from the degradation of RDX.	Nitrates	76-83	radixin	Homo sapiens	122-125
18702296-4	2008	Nitrate and organic matter expressed as dissolved organic carbon were 50 mgl(-1) and 20 mgl(-1), respectively, in the inlet.	Nitrates	0-7	LLGL scribble cell polarity complex component 1	Homo sapiens	73-79
18702296-4	2008	Nitrate and organic matter expressed as dissolved organic carbon were 50 mgl(-1) and 20 mgl(-1), respectively, in the inlet.	Nitrates	0-7	LLGL scribble cell polarity complex component 1	Homo sapiens	88-94
18417639-3	2008	In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI.	Nitrates	122-129	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	83-86
32688789-5	2008	Transcript levels of NR (nitrate reductase) and its cofactor binding domain genes FAD (FAD binding) and CYP51G1 (Heme binding), the activity of nitrate reductase (NR, EC 1.6.6.1) and the nitrate reduction process were each greatly enhanced by Put application, particularly in roots exposed to hypoxia.	Nitrates	25-32	nitrate reductase [NADH]-like	Cucumis sativus	21-23
32688789-8	2008	These results suggest that Put enhances tolerance to hypoxia by increasing the transcript levels of NR and its cofactor binding domain genes, thereby stimulating the activities of NR and nitrate reduction to maintain the redox and energy status.	Nitrates	187-194	nitrate reductase [NADH]-like	Cucumis sativus	100-102
18266918-0	2008	Nitrate signalling mediated by the NRT1.1 nitrate transporter antagonises L-glutamate-induced changes in root architecture.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	35-41
18417639-3	2008	In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI.	Nitrates	122-129	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	116-120
18417639-3	2008	In a screen for genes whose expression was altered in response to the induction of AP3 activity, we identified GNC (GATA, nitrate-inducible, carbon-metabolism-involved) as being negatively regulated by AP3 and PI.	Nitrates	122-129	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	202-205
18546685-1	2008	Aerobic conditions in desert aquifers commonly allow high nitrate (NO3-) concentrations in recharge to persist for long periods of time, an important consideration for N-cycling and water quality.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
18483281-2	2008	Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780.	Nitrates	90-97	progesterone receptor	Homo sapiens	190-211
18329686-3	2008	Elevated nutrients were found in all wells where significant concentrations of both tracers were observed, with the mean of the highest nitrate (NO3) concentration observed at each well being 47.8+/-14.9 (n=11) mg/L NO3-N.	Nitrates	136-143	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
18483281-2	2008	Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780.	Nitrates	90-97	progesterone receptor	Homo sapiens	213-216
18483281-2	2008	Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780.	Nitrates	90-97	trefoil factor 1	Homo sapiens	219-222
18483281-2	2008	Similar to estradiol, treatment of MCF-7 cells with either 1 mumol/L nitrite or 1 mumol/L nitrate resulted in approximately 4-fold increase in cell growth and 2.3-fold to 3-fold increase in progesterone receptor (PgR), pS2, and cathepsin D mRNAs that were blocked by the antiestrogen ICI 182,780.	Nitrates	90-97	cathepsin D	Homo sapiens	228-239
18483281-5	2008	The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERalpha suggests that nitrite is the active anion.	Nitrates	59-66	progesterone receptor	Homo sapiens	105-108
18483281-5	2008	The ability of diphenyleneiodonium to block the effects of nitrate, but not nitrite, on the induction of PgR mRNA and the activation of exogenously expressed ERalpha suggests that nitrite is the active anion.	Nitrates	59-66	estrogen receptor 1	Homo sapiens	158-165
18453433-1	2008	Physical, chemical, hydrologic, and biologic factors affecting nitrate (NO3(-)) removal were evaluated in three agricultural streams draining orchard/dairy and row crop settings.	Nitrates	63-70	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
18453433-9	2008	Nitrate retention as a percentage of gross NO3(-) inputs was &gt;30% in an organic-poor, autotrophic stream with the lowest denitrification potentials and highest benthic chlorophyll a, photosynthesis/respiration ratio, pH, dissolved oxygen, and diurnal NO3(-) variation.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	43-46
18453433-9	2008	Nitrate retention as a percentage of gross NO3(-) inputs was &gt;30% in an organic-poor, autotrophic stream with the lowest denitrification potentials and highest benthic chlorophyll a, photosynthesis/respiration ratio, pH, dissolved oxygen, and diurnal NO3(-) variation.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	254-257
18655580-2	2008	On the 7th day under nitrate stress, the shoot fresh mass per plant decreased by 12.77 g, leaf SOD, POD and CAT activities increased, while leaf APX, DHAR and GR activities decreased significantly, compared with the control.	Nitrates	21-28	catalase isozyme 1	Cucumis sativus	108-111
18284212-5	2008	Of the anions studied, particularly intriguing in terms of observed trends in substrate kinetics and their novel atomic compositions were the nitrite, nitrate, and azide anions, the latter of which was found to enhance the relative activity of human pancreatic alpha-amylase by nearly 5-fold.	Nitrates	151-158	amylase alpha 2A	Homo sapiens	250-274
18213641-9	2008	Exposure to arsenic compounds, chlorophenols, diesel fuel, herbicides, nitrites/nitrates/nitrosamines, and organic dusts were associated with NHL(high) and NHL(low), while exhibiting little association with CLL.	Nitrates	80-88	regulator of telomere elongation helicase 1	Homo sapiens	142-145
18713378-4	2008	The present study identified four putative NRT2 and two putative NAR2 genes that encode components of the high-affinity nitrate transport system (HATS) in the rice (Oryza sativa L. subsp.	Nitrates	120-127	nitrate transporter 2:1	Arabidopsis thaliana	43-47
17923423-5	2008	RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production.	Nitrates	164-171	tumor necrosis factor	Bos taurus	9-18
17923423-5	2008	RESULTS: TNF-alpha and IL-1beta treatment caused a 3-5 fold increase in sGAG release with an increase in aggrecanase-specific aggrecan breakdown and an increase in nitrate and nitrite production.	Nitrates	164-171	interleukin 1 beta	Bos taurus	23-31
18714730-7	2008	Pre-block of ACE by captopril intensified diuresis and inhibited renal excretion of OAS, nitrites and nitrates in response to T4 injection.	Nitrates	102-110	angiotensin I converting enzyme	Rattus norvegicus	13-16
18326829-8	2008	The hot5 null alleles show increased nitrate and nitroso species levels, and the heat sensitivity of both missense and null alleles is associated with increased NO species.	Nitrates	37-44	GroES-like zinc-binding dehydrogenase family protein	Arabidopsis thaliana	4-8
18158911-5	2008	Nitric oxide has been reported to react easily with oxygen captured in hemoglobin to form nitrate, but not toxic free radicals, which may result in production of methemoglobin for the cytochrome b5 to regenerate functional ferrous hemoglobin.	Nitrates	90-97	hemoglobin subunit gamma 2	Homo sapiens	162-175
18164678-2	2008	Electron density maps obtained from crystals grown in presence of Al(NO3)3 show a nitrate ion instead of the expected AlF4- in the catalytic site.	Nitrates	82-89	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
18341112-6	2008	Seasonal variation in TOC was mainly climatically controlled, whereas deposition of sulfate and nitrate (NO3) explained the long-term TOC increase.	Nitrates	96-103	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
18061242-4	2008	It is further demonstrated that reactions in/on sea-spray affect the entire particle ensemble and particularly the size distribution of particle nitrate, but that the importance of these heterogeneous reactions is critically dependent on both the initial vertical profile of sea spray and the sea-spray source functions.	Nitrates	145-152	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	48-51
18266427-0	2008	High field 207Pb spin-lattice relaxation in solid lead nitrate and lead molybdate.	Nitrates	55-62	spindlin 1	Homo sapiens	17-21
18164136-6	2008	Furthermore, at 4 weeks, the nNOS protein content and NO production as reflected by the concentration of nitrite and nitrate were drastically elevated as measured by Western blot analysis and NO colorimetric assay, respectively.	Nitrates	117-124	nitric oxide synthase, brain	Cavia porcellus	29-33
18341114-5	2008	For nitrate (NO3) and ammonium in runoff, the reverse is true.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	13-16
18341115-3	2008	Increased soil temperatures during winter increased the springtime concentrations and fluxes of ammonium (NH4) and nitrate (NO3) in runoff.	Nitrates	115-122	NBL1, DAN family BMP antagonist	Homo sapiens	124-127
18341119-1	2008	The mass transport model TEOTIL was used to project nitrate (NO3) fluxes from the Tovdal River basin, southernmost Norway, given four scenarios of climate change.	Nitrates	52-59	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
18157715-1	2008	This article presents the results of mass concentration of major acidic anions (chlorides, nitrates and sulphates) in TSP and PM(10) particle fraction in Zagreb air measured continuously at one measuring site in 2004.	Nitrates	91-99	thrombospondin 1	Homo sapiens	118-121
18037907-9	2008	CONCLUSIONS AND IMPLICATIONS: Nitrate tolerance induced by NTG at low concentrations may result from an increased production of reactive oxygen species acting on sites upstream of PKG.	Nitrates	30-37	protein kinase cGMP-dependent 1	Homo sapiens	180-183
18817197-6	2008	Chloride (Cl) and nitrate (NO3) concentrations were higher than the permissible limits according to World Health Organization Standards.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
18199125-2	2008	This process is carried out by two heterotetrameric enzymes that catalyse the oxidation of NADH (Nrc) and the reduction of nitrate (Nar), whose expression is activated by the NCE-encoded transcription factors DnrS and DnrT.	Nitrates	123-130	nuclear receptor coactivator 6	Homo sapiens	97-100
18199125-4	2008	We encountered that nrc mutants of denitrifying strains show a decrease in anaerobic growth rates not only with nitrate, but also with nitrite, NO and N(2)O, which is concomitant to their lower NADH oxidation activities in vitro.	Nitrates	112-119	nuclear receptor coactivator 6	Homo sapiens	20-23
18199125-5	2008	We show that nitrate, nitrite and NO are activating signals for transcription of nrc in these strains.	Nitrates	13-20	nuclear receptor coactivator 6	Homo sapiens	81-84
18078452-5	2008	Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium.	Nitrates	120-127	interferon gamma	Rattus norvegicus	19-28
18006476-5	2008	METHODS AND RESULTS: Treatment of vascular EC with a FXR ligand resulted in upregulation of expression of eNOS mRNA and protein and an increased production of nitrite/nitrate.	Nitrates	167-174	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	53-56
17938848-3	2008	Recent studies revealed that mitochondrial reactive oxygen species (ROS) formation and a subsequent oxidative inactivation of nitrate reductase, the mitochondrial aldehyde dehydrogenase (ALDH-2), play an important role for the development of nitrate and crosstolerance.	Nitrates	126-133	aldehyde dehydrogenase 2 family member	Homo sapiens	187-193
17938848-4	2008	The present review focuses firstly on the role of ALDH-2 for organic nitrate bioactivation and secondly on the role of oxidative stress in the development of tolerance and cross-tolerance (endothelial dysfunction) in response to various organic nitrates.	Nitrates	69-76	aldehyde dehydrogenase 2 family member	Homo sapiens	50-56
19213313-1	2008	The interactions of nitrate with Cu(100) and Cu(111) in acidic solution are studied by cyclic voltammetry (CV) and in situ electrochemical scanning tunneling microscopy (EC-STM).	Nitrates	20-27	sulfotransferase family 1A member 3	Homo sapiens	173-176
18267946-0	2008	Senescence-induced ectopic expression of the A. tumefaciens ipt gene in wheat delays leaf senescence, increases cytokinin content, nitrate influx, and nitrate reductase activity, but does not affect grain yield.	Nitrates	131-138	Ipt	Agrobacterium tumefaciens	60-63
18078452-5	2008	Treatment with LPS/IFN-gamma for 24 hr elicited the induction of inducible (iNOS) activity as determined by nitrite and nitrate (NO(x)) accumulation in the culture medium.	Nitrates	120-127	nitric oxide synthase 2	Rattus norvegicus	76-80
18181234-2	2008	The method is composed of the traditional oxidation/reduction methods, such as the oxidation of PON to nitrate (NO3*) using persulfate, the reduction of NO3* to nitrite (NO2*) using spongy cadmium, and further reduction of NO2* to nitrous oxide (N2O) using sodium azide.	Nitrates	103-110	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
22062097-5	2008	Nitrite added to a batter of meat is partially oxidized to nitrate by sequestering oxygen - thus it acts as an antioxidant - a part of nitrite is bound to myoglobin, forming the heat stable NO-myoglobin, a part is bound to proteins or other substances in meat.	Nitrates	59-66	myoglobin	Homo sapiens	193-202
18077439-7	2007	Molybdate uptake mediated by MOT1 showed a K(m) of approximately 6 nM, which is the range of the lowest K(m) values reported and was activated in the presence of nitrate.	Nitrates	162-169	DNA-binding ATPase	Saccharomyces cerevisiae S288C	29-33
18441434-0	2008	Effect of nitrate on the reduction of Reactive Red 2 by mesophilic anaerobic sludge.	Nitrates	10-17	adenosine deaminase RNA specific B2 (inactive)	Homo sapiens	47-52
17492487-1	2007	Water with high nitrate concentration (NO(3) (-)) is unfit for human consumption, especially when its concentration exceeded the threshold limit (50 mg/l) recommended by the health authorities such as the World Health Organization (WHO).	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	39-44
18213972-1	2007	A century-long increase in nitrate (NO3-) in the water column of Lake Superior is a classic example of recent nitrogen accumulation in ecosystems, but its cause and relationship to historical NO3- deposition is unknown.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
18024571-0	2007	Nitrate signaling by the regulatory gene NIT2 in Chlamydomonas.	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	41-45
18041625-5	2007	Anthropogenic impact was detected only in a tributary stream of the River Sava, which is located in an agriculture-industrial area and is reflected in higher delta(15)N values in suspended matter and high nitrate concentrations in the late summer season.	Nitrates	205-212	T-box transcription factor T	Homo sapiens	74-78
17898699-4	2007	Repeated intravenous doses of cationized catalase significantly decreased cisplatin-induced changes in serum creatinine, blood urea nitrogen, nitrite/nitrate levels, lactic dehydrogenase activity, and renal total glutathione and malondialdehyde contents.	Nitrates	150-157	catalase	Mus musculus	41-49
17958340-1	2007	The photolysis wavelength dependence of the nitrate radical quantum yield for peroxyacetyl nitrate (CH(3)C(O)OONO(2), PAN) is investigated.	Nitrates	44-51	adenosine deaminase 2	Homo sapiens	118-121
17958340-3	2007	We find the nitrate radical quantum yield from PAN photolysis to be essentially invariant; Phi(NO3)(PAN) = 0.30 +/- 0.07 (+/-2sigma) in this region.	Nitrates	12-19	adenosine deaminase 2	Homo sapiens	47-50
18044493-5	2007	For an average fertilizer application rate of 90 kg of N/ha, the simulated nitrate concentration on Oct 1 within the top 1 m of soil is 33 mg of N/kg, while the residual soil nitrate measured in late September was 37 mg of N/kg.	Nitrates	75-82	solute carrier family 22 member 1	Homo sapiens	100-105
17948780-1	2007	We used the dual isotope approach to identify sources of nitrate (NO3-) to two mixed land-use watersheds draining to Long Island Sound.	Nitrates	57-64	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
31348636-6	2019	Adsorption experiment with anions such as phosphate (HPO42-) and nitrate (NO3-) was conducted by using ClO4-roseLDH and Cl-roseLDH.	Nitrates	65-72	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
18852825-0	2007	Structural and Physical Characterization of (Nitrato)iron(III) Porphyrinates [Fe(por)(NO(3))] - Variable Coordination of Nitrate.	Nitrates	121-128	cytochrome p450 oxidoreductase	Homo sapiens	81-84
17672841-5	2007	Expression of the AtDUR3 gene in nitrogen-deficient roots was repressed by ammonium and nitrate but induced after supply of urea.	Nitrates	88-95	urea-proton symporter DEGRADATION OF UREA 3 (DUR3)	Arabidopsis thaliana	18-24
17585900-9	2007	The present results suggest that nitrate tolerance is, at least partially, associated with a decrease in endogenous CGRP release via a decrease in ALDH-2 activity as a result of stimulation of reactive oxygen species production.	Nitrates	33-40	calcitonin related polypeptide alpha	Homo sapiens	116-120
17585900-9	2007	The present results suggest that nitrate tolerance is, at least partially, associated with a decrease in endogenous CGRP release via a decrease in ALDH-2 activity as a result of stimulation of reactive oxygen species production.	Nitrates	33-40	aldehyde dehydrogenase 2 family member	Homo sapiens	147-153
18024571-3	2007	Each of these 10 lines was mutated in the nitrate assimilation-specific regulatory gene NIT2.	Nitrates	42-49	uncharacterized protein	Chlamydomonas reinhardtii	88-92
18024571-6	2007	NIT2 expression is negatively regulated by ammonium and is optimal in N-free medium with no need for the presence of nitrate.	Nitrates	117-124	uncharacterized protein	Chlamydomonas reinhardtii	0-4
18024571-7	2007	However, intracellular nitrate is required to allow Nit2 to activate the NIA1 promoter activity.	Nitrates	23-30	uncharacterized protein	Chlamydomonas reinhardtii	52-56
18024571-9	2007	Our data indicate that NIT2 is a central regulatory gene required for nitrate signaling on the Chlamydomonas NIA1 gene promoter and that intracellular nitrate is needed for NIT2 function and to modulate NIA1 transcript levels.	Nitrates	70-77	uncharacterized protein	Chlamydomonas reinhardtii	23-27
18024571-9	2007	Our data indicate that NIT2 is a central regulatory gene required for nitrate signaling on the Chlamydomonas NIA1 gene promoter and that intracellular nitrate is needed for NIT2 function and to modulate NIA1 transcript levels.	Nitrates	151-158	uncharacterized protein	Chlamydomonas reinhardtii	173-177
17555556-6	2007	Motoneuron survival was inversely correlated with nitrate + nitrite concentrations in mSOD1(G93A) co-cultures, suggesting the important role of nitric oxide in microglia-induced motoneuron injury.	Nitrates	50-57	superoxide dismutase 1, soluble	Mus musculus	86-91
17709521-8	2007	The NOS2 genotype observed in healthy controls was correlated with an increase in NOS2 expression and higher concentrations of nitrate and nitrite in control serum.	Nitrates	127-134	nitric oxide synthase 2	Homo sapiens	4-8
17541025-8	2007	CONCLUSIONS: HO-1 expression and activity appear to play a key role in the development of nitrate tolerance and might represent an intrinsic antioxidative mechanism of therapeutic interest.	Nitrates	90-97	heme oxygenase 1	Rattus norvegicus	13-17
17766834-8	2007	The timing of P release was inversely related to the nitrate (NO3-) concentration in floodwater.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
17611046-1	2007	Escherichia coli flavohaemoglobin (Hmp) is the best-understood nitric oxide (NO) detoxifying protein and exhibits a robust dioxygenase activity, converting NO to nitrate ion with oxygen as co-substrate.	Nitrates	162-169	inner membrane mitochondrial protein	Homo sapiens	35-38
17655297-1	2007	Nitrate adsorption and reduction on Cu(100) in acidic solution is studied by electrochemical methods, in situ electrochemical scanning tunneling microscopy (EC-STM), surface enhanced Raman spectroscopy (SERS), and density functional theory (DFT) calculations.	Nitrates	0-7	sulfotransferase family 1A member 3	Homo sapiens	160-163
17655297-2	2007	Electrochemical results show that reduction of nitrate starts at -0.3 V vs Ag/AgCl and reaches maximum value at -0.58 V. Over the entire potential region interrogated adlayers composed of nitrate, nitrite, or other intermediates are observed by using in situ STM.	Nitrates	47-54	sulfotransferase family 1A member 3	Homo sapiens	259-262
17573350-0	2007	Regulation of root nitrate uptake at the NRT2.1 protein level in Arabidopsis thaliana.	Nitrates	19-26	nitrate transporter 2:1	Arabidopsis thaliana	41-47
17573350-1	2007	In Arabidopsis the NRT2.1 gene encodes a main component of the root high-affinity nitrate uptake system (HATS).	Nitrates	82-89	nitrate transporter 2:1	Arabidopsis thaliana	19-25
17541025-0	2007	Heme oxygenase-1: a novel key player in the development of tolerance in response to organic nitrates.	Nitrates	92-100	heme oxygenase 1	Rattus norvegicus	0-16
17541025-1	2007	OBJECTIVE: Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling.	Nitrates	11-18	aldehyde dehydrogenase 2 family member	Rattus norvegicus	144-180
17541025-1	2007	OBJECTIVE: Nitrate tolerance is likely attributable to an increased production of reactive oxygen species (ROS) leading to an inhibition of the mitochondrial aldehyde dehydrogenase (ALDH-2), representing the nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN) bioactivating enzyme, and to impaired nitric oxide bioactivity and signaling.	Nitrates	11-18	aldehyde dehydrogenase 2 family member	Rattus norvegicus	182-188
17526746-6	2007	Interestingly, the membrane nitrate reductase mutant was avirulent in C. elegans, while nitrate sensor-response regulator mutants were fully virulent.	Nitrates	28-35	reductase	Pseudomonas aeruginosa PAO1	36-45
17559573-2	2007	Extracts of maltose/yeast extract/nitrate-grown cells contained all enzyme activities of a modified Embden-Meyerhof (EM) pathway, including ATP-dependent glucokinase, phosphoglucose isomerase, ATP-dependent 6-phosphofructokinase, fructose-1,6-phosphate aldolase, triose-phosphate isomerase, GAPOR, phosphoglycerate mutase, enolase and pyruvate kinase.	Nitrates	34-41	phosphoglycerate mutase	Saccharomyces cerevisiae S288C	298-321
17622411-5	2007	On the average, the dissociated nitrate interacts with 2 to 4 cs3 molecules, whereas the associated nitrate (LCs(+)NO(3)(-) complex) interacts with one cs3 dimer.	Nitrates	32-39	myozenin 3	Homo sapiens	62-65
17722702-5	2007	In the presence of high levels of nitrate or ammonium, the NIN gene fails to be induced 24 h after the addition of Nod factor compared with plants grown under N-free conditions.	Nitrates	34-41	nin	Lotus japonicus	59-62
17722702-6	2007	This induction is restored in the hypernodulating nitrate-tolerant har1-3 mutant only in the presence of 10 and 20 mM KNO3.	Nitrates	50-57	CM0216.560.nc	Lotus japonicus	67-71
17722702-8	2007	NIN plays a key role in the nodule organogenesis program and its downregulation may represent a crucial event in the nitrate-dependent pathway leading to the inhibition of nodule organogenesis.	Nitrates	117-124	nin	Lotus japonicus	0-3
17606840-10	2007	The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2.	Nitrates	89-97	nitric oxide synthase 3, endothelial cell	Mus musculus	15-19
17606840-10	2007	The effects of eNOS-derived NO are reproduced by exogenous NO (NO donors), implying that nitrates can upregulate cardiac cyclooxygenase-2.	Nitrates	89-97	prostaglandin-endoperoxide synthase 2	Mus musculus	121-137
17622411-5	2007	On the average, the dissociated nitrate interacts with 2 to 4 cs3 molecules, whereas the associated nitrate (LCs(+)NO(3)(-) complex) interacts with one cs3 dimer.	Nitrates	100-107	myozenin 3	Homo sapiens	152-155
17571880-3	2007	A second, and sometimes third, oxidation peak was also observed when the anodic limit was extended, and these were provisionally assigned to the oxidation of nitrogen dioxide (NO2) and nitrate (NO3-), respectively.	Nitrates	185-192	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
17475504-8	2007	Levels of circulating nitrite/nitrate, the end-metabolites of nitric oxide, were also significantly affected by ACE inhibition, with the same order of potency.	Nitrates	30-37	angiotensin I converting enzyme	Rattus norvegicus	112-115
17467673-6	2007	PDE1 and/or PDE5 are also reportedly up-regulated in chronic disease conditions such as atherosclerosis or cardiac pressure-load stress and heart failure as well as in response to long-term exposure to nitrates.	Nitrates	202-210	phosphodiesterase 5A	Homo sapiens	12-16
19704673-3	2007	Using heterologous expression in yeast and oocytes we showed that the two Arabidopsis AtNRT2.1 and AtNAR2.1 proteins interacted to give a functional high affinity nitrate transport system (HATS).	Nitrates	163-170	nitrate transporter 2:1	Arabidopsis thaliana	86-94
17559208-3	2007	Three novel crystal structures and FT-IR spectra of metal nitrate-galactitol complexes of La(NO3)3.C6H14O6.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	93-96
17347445-8	2007	There was a trend toward enhanced production of nitrate relative to nitrite as an end product of NO metabolism in IL-13-stimulated cells.	Nitrates	48-55	interleukin 13	Homo sapiens	114-119
17566055-9	2007	CsNitr1-L may possibly load cytosolic nitrite into chloroplast stroma in the chloroplast envelope during nitrate assimilation.	Nitrates	105-112	probable nitrite transporter At1g68570-like	Cucumis sativus	0-7
17482833-1	2007	Exposure to nitrates causes tachyphylaxis to nitric oxide (NO), which reduces the effects of the second messenger cyclic guanosine-3",-5"-monophosphate (cyclic GMP).	Nitrates	12-20	5'-nucleotidase, cytosolic II	Homo sapiens	160-163
17336418-8	2007	PPT/DPN reduced nitrate/nitrite production and iNOS mRNA in Kupffer cells following trauma-hemorrhage; however, these levels in DPN-treated animals remained higher than sham.	Nitrates	16-23	tachykinin, precursor 1	Rattus norvegicus	0-3
17523628-3	2007	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, a change in free energy of +6 kcal/mol is predicted for eta(2)- to eta(1)-transition of one of the three nitrate ligands in the gas phase.	Nitrates	208-215	DNA polymerase iota	Homo sapiens	159-165
17523628-3	2007	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, a change in free energy of +6 kcal/mol is predicted for eta(2)- to eta(1)-transition of one of the three nitrate ligands in the gas phase.	Nitrates	208-215	secreted phosphoprotein 1	Homo sapiens	170-176
17523628-5	2007	This contrasts with the aqueous solution where the nitrate binds in a eta(1)-fashion and uranyl coordinates to four H2O ligands.	Nitrates	51-58	secreted phosphoprotein 1	Homo sapiens	70-76
17523628-9	2007	The [UO(2)(NO(3))(4)](2-) complex with two eta(2)- and two eta(1)- coordinated nitrates, observed in the solid state, is stable for 1-2 ps in the gas phase and in solution.	Nitrates	79-87	secreted phosphoprotein 1	Homo sapiens	59-65
17503808-4	2007	The addition of Cl- anions promotes the solubilization of the nitrate and triflate salts in the C4mimPF6 and the C4mimBF4 ILs via the formation of chloro complexes, also formed with other salts.	Nitrates	62-69	complement C4A (Rodgers blood group)	Homo sapiens	96-104
17277235-7	2007	We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form.	Nitrates	51-58	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	84-90
17277235-7	2007	We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form.	Nitrates	51-58	nocturnin	Homo sapiens	135-138
17548042-4	2007	As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge.	Nitrates	94-101	interleukin 1 alpha	Mus musculus	149-158
17493633-0	2007	Increased superoxide production in nitrate tolerance is associated with NAD(P)H oxidase and aldehyde dehydrogenase 2 downregulation.	Nitrates	35-42	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	92-116
17493633-3	2007	Using cell culture and animal models of nitrate tolerance, we aimed to assess the impact of nitrates on NAD(P)H oxidases and aldehyde dehydrogenase 2 (ALDH2) expression.	Nitrates	92-100	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	125-149
17493633-3	2007	Using cell culture and animal models of nitrate tolerance, we aimed to assess the impact of nitrates on NAD(P)H oxidases and aldehyde dehydrogenase 2 (ALDH2) expression.	Nitrates	92-100	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	151-156
17493633-13	2007	In addition, expression and activity of ALDH-2 was decreased in nitrate-tolerant rings.	Nitrates	64-71	aldehyde dehydrogenase 2 family member	Rattus norvegicus	40-46
17617676-10	2007	Interestingly, the addition of NAC to lead nitrate-treated HepG2 cells significantly decreased cellular content of reactive oxygen species (ROS), as evidenced by the decrease in lipid peroxidation byproducts.	Nitrates	43-50	X-linked Kx blood group	Homo sapiens	31-34
17617676-11	2007	Overall, findings from this study suggest that NAC inhibits lead nitrate-induced cytotoxicity and oxidative stress in HepG2 cells.	Nitrates	65-72	X-linked Kx blood group	Homo sapiens	47-50
17548042-4	2007	As compared with wild-type mice, the increases in the plasma NO level measured as nitrite and nitrate and hepatic iNOS were significantly reduced in IL-1alpha/beta(-/-) and TNFalpha(-/-) mice 8 and 12h after the LPS challenge.	Nitrates	94-101	tumor necrosis factor	Mus musculus	173-181
17481610-5	2007	Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake.	Nitrates	120-127	nitrate transporter 1.1	Arabidopsis thaliana	11-15
17481610-5	2007	Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake.	Nitrates	120-127	nitrate transporter 1:2	Arabidopsis thaliana	32-40
17481610-5	2007	Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake.	Nitrates	120-127	nitrate transporter 2:1	Arabidopsis thaliana	57-61
17481610-5	2007	Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake.	Nitrates	120-127	nitrate transporter 2:1	Arabidopsis thaliana	69-77
17481610-5	2007	Two of the NRT1 genes, CHL1 and AtNRT1.2, and two of the NRT2 genes, AtNRT2.1 and AtNRT2.2, are known to be involved in nitrate uptake.	Nitrates	120-127	nitrate transporter 2:1	Arabidopsis thaliana	69-75
17481610-6	2007	In addition, AtNRT1.4 is required for petiole nitrate storage.	Nitrates	46-53	nitrate transporter 1.1	Arabidopsis thaliana	13-19
17485712-1	2007	Nitrate (NO3-) leaching to ground water poses water quality concerns in some settings.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
17540716-0	2007	The Arabidopsis ATNRT2.7 nitrate transporter controls nitrate content in seeds.	Nitrates	25-32	high affinity nitrate transporter 2.7	Arabidopsis thaliana	16-24
17229473-6	2007	Moreover, leptin increased plasma concentration and urinary excretion of NO metabolites, nitrites+nitrates (NO(x)), and of NO second messenger, cyclic GMP.	Nitrates	98-106	leptin	Rattus norvegicus	10-16
17183346-3	2007	As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease.	Nitrates	87-95	phosphodiesterase 5A	Homo sapiens	9-28
17183346-3	2007	As these phosphodiesterase 5 (PDE5) inhibitors all increase the hypotensive effects of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease.	Nitrates	87-95	phosphodiesterase 5A	Homo sapiens	30-34
17540716-1	2007	In higher plants, nitrate is taken up by root cells where Arabidopsis thaliana NITRATE TRANSPORTER2.1 (ATNRT2.1) chiefly acts as the high-affinity nitrate uptake system.	Nitrates	18-25	nitrate transporter 2:1	Arabidopsis thaliana	79-101
17540716-1	2007	In higher plants, nitrate is taken up by root cells where Arabidopsis thaliana NITRATE TRANSPORTER2.1 (ATNRT2.1) chiefly acts as the high-affinity nitrate uptake system.	Nitrates	147-154	nitrate transporter 2:1	Arabidopsis thaliana	79-101
17540716-6	2007	We assessed the capacity of ATNRT2.7 to transport nitrate in Xenopus laevis oocytes or when it is expressed ectopically in mutant plants deficient in nitrate transport.	Nitrates	50-57	high affinity nitrate transporter 2.7	Arabidopsis thaliana	28-36
17540716-6	2007	We assessed the capacity of ATNRT2.7 to transport nitrate in Xenopus laevis oocytes or when it is expressed ectopically in mutant plants deficient in nitrate transport.	Nitrates	150-157	high affinity nitrate transporter 2.7	Arabidopsis thaliana	28-36
17540716-8	2007	By contrast, seed nitrate content was affected by overexpression of ATNRT2.7 or a mutation in the gene.	Nitrates	18-25	high affinity nitrate transporter 2.7	Arabidopsis thaliana	68-76
17540716-10	2007	Our results demonstrate that ATNRT2.7 plays a specific role in nitrate accumulation in the seed.	Nitrates	63-70	high affinity nitrate transporter 2.7	Arabidopsis thaliana	29-37
17094870-3	2007	Here, we investigated whether NOS2-mediated nitrite/nitrate synthesis modulates responsiveness to inhaled NO.	Nitrates	52-59	nitric oxide synthase 2	Rattus norvegicus	30-34
17306574-2	2007	We evaluated the association of eNOS genotypes/haplotypes with the plasma concentrations of nitrite/nitrate (NO(x)), which are products of nitric oxide in HT, T2DM, and T2DM+HT patients.	Nitrates	100-107	nitric oxide synthase 3	Homo sapiens	32-36
17520925-7	2007	In the estuary bay with a long residence time, in the Archipelago Sea, up to 4.5% of nitrate loading and 19% of nitrogen loading were removed before entering the sea.	Nitrates	85-92	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	66-69
17696737-2	2007	The aim of the present study was to quantify nitrate+nitrite (NO2+NO3) in tobacco products as well as to study tobacco exposure related biomarkers in controls, patients with oral precancers (OPC) and oral cancer patients.	Nitrates	45-52	NBL1, DAN family BMP antagonist	Homo sapiens	66-69
17363026-1	2007	In agricultural areas, nitrate (NO3-) is a common groundwater pollutant as a result of extensive fertilizer application.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	32-35
17094870-11	2007	Here, responsiveness to inhaled NO is dependent on the ability of NOS2 inhibitors to reduce nitrite and nitrate levels in serum and released in the lung.	Nitrates	104-111	nitric oxide synthase 2	Rattus norvegicus	66-70
17329906-0	2007	Cytochrome P450 is responsible for nitric oxide generation from NO-aspirin and other organic nitrates.	Nitrates	93-101	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
17242981-4	2007	Using the hph-1 mouse, which displays a partial BH4 deficiency owing to impaired activity of GTP cyclohydrolase, we report decreased levels of glutathione in brain and kidney and evidence for decreased basal generation of nitric oxide in the periphery (as judged by the plasma nitrate plus nitrite concentration).	Nitrates	277-284	hyperphenylalaninemia 1	Mus musculus	10-15
17242981-6	2007	However, the concentration of plasma nitrate plus nitrite achieved was significantly decreased in the hph-1 mouse.	Nitrates	37-44	hyperphenylalaninemia 1	Mus musculus	102-107
17450295-6	2007	As a result, the depth to which dissolved anthropogenic N as nitrate (NO3) is leached early in the winter wet season is limited to within the top approximately 130 cm of soil where it accumulates and increases soil acidity.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
17355433-5	2007	Supplied with insufficient inorganic nitrogen (nitrate or ammonium), the nla mutant failed to develop the essential adaptive responses to nitrogen limitation, but senesced much earlier and more rapidly than did the wild type.	Nitrates	47-54	SPX (SYG1/Pho81/XPR1) domain-containing protein	Arabidopsis thaliana	73-76
17056288-4	2007	In the present study, we used an ultra-sensitive NO-selective electrochemical sensor (AmiNO700) in combination with a highly efficient nitrate conversion method, which coupled the nitrate reductase step with the glucose-6-phosphate dehydrogenase system.	Nitrates	135-142	glucose-6-phosphate dehydrogenase	Homo sapiens	212-245
17329906-2	2007	We have previously reported that cytochrome P450 (P450) plays important role in NO generation from other organic nitrates such as nitroglycerin (NTG) and isosorbide dinitrate (ISDN).	Nitrates	113-121	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	33-48
17249740-1	2007	Concentrated aqueous nitrate aerosols are present in the Earth"s atmosphere as a result of heterogeneous reactions of sea salt and mineral dust aerosol with nitrogen oxides (e.g., NO2, NO3, HNO3 and N2O5).	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	185-188
17173980-5	2007	CLP led to increased plasma nitrate levels, protein leakage and hypotension and caused mortality of 80% by 24 h. Expression of c-fos in paraventricular (PVN), supraoptic (SON) and organum vasculosum of lamina terminalis (OVLT) nuclei, as well as plasma AVP concentration were increased at 6 h but reduced to basal levels 24 h after CLP.	Nitrates	28-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	127-132
17275683-12	2007	Inflammatory activity was reduced in the rats receiving nitrate as indicated by lower mucosal myeloperoxidase activity and expression of inducible NO synthase.	Nitrates	56-63	myeloperoxidase	Rattus norvegicus	94-109
17275683-12	2007	Inflammatory activity was reduced in the rats receiving nitrate as indicated by lower mucosal myeloperoxidase activity and expression of inducible NO synthase.	Nitrates	56-63	nitric oxide synthase 2	Rattus norvegicus	137-158
17220910-0	2007	Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.	Nitrates	70-78	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	108-114
17220910-1	2007	BACKGROUND AND PURPOSE: Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates.	Nitrates	135-143	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	62-68
17220910-1	2007	BACKGROUND AND PURPOSE: Mitochondrial aldehyde dehydrogenase (ALDH-2) has been shown to provide a pathway for bioactivation of organic nitrates and to be prone to desensitization in response to highly potent, but not to less potent, nitrates.	Nitrates	233-241	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	62-68
17220910-2	2007	We therefore sought to support the hypothesis that bioactivation by ALDH-2 critically depends on the number of nitrate groups within the nitrovasodilator.	Nitrates	111-118	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	68-74
17220910-10	2007	CONCLUSIONS AND IMPLICATIONS: Our results support the crucial role of ALDH-2 in bioactivating highly reactive nitrates like GTN, PETN and PETriN.	Nitrates	110-118	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	70-76
17220910-11	2007	ALDH-2-mediated relaxation by organic nitrates therefore depends mainly on the number of nitrate groups.	Nitrates	38-46	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	0-6
17220910-11	2007	ALDH-2-mediated relaxation by organic nitrates therefore depends mainly on the number of nitrate groups.	Nitrates	38-45	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	0-6
17265003-5	2007	Denitrification was positively related to nitrate (NO3 ) concentration, suggesting that sediments may have been nutrient-limited.	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
17220512-9	2007	The enzyme activity of glucose 6-phosphate dehydrogenase (G6PDH), the enzyme supporting the first step of the OPPP, was induced by external nitrate supply.	Nitrates	140-147	glucose-6-phosphate dehydrogenase	Homo sapiens	23-56
17172286-6	2007	Moreover, steady-state transcript levels were decreased after addition of ammonium or nitrate in N-deficient roots, suggesting a role for N availability in regulating AtAMT1;1 transcript abundance.	Nitrates	86-93	ammonium transporter 1;1	Arabidopsis thaliana	167-175
16872740-6	2007	A concomitant removal of 97% of nitrate was observed for a mean influent concentration of 423.4 mg L-1.	Nitrates	32-39	immunoglobulin kappa variable 1-16	Homo sapiens	99-102
17364893-3	2007	The activity and expression of eNOS, measured by nitrate levels and immunoblot, respectively, were determined following exposure of BRECs to varying concentrations of glucose and mannitol (0 to 25 mM).	Nitrates	49-56	nitric oxide synthase 3	Bos taurus	31-35
17364893-4	2007	Under static conditions the expression of eNOS decreased significantly following exposure to increasing concentrations of glucose when compared to osmotic mannitol controls and was accompanied by a significant dose-dependent decrease in nitrate levels in conditioned medium.	Nitrates	237-244	nitric oxide synthase 3	Bos taurus	42-46
18232232-4	2007	It restricted uptake and transport of NO3(-), inhibited activity of some key nitrogen-metabolism-related enzymes, such as: nitrate reductase (NR) to the nitrate reduction, glutamine systhetase (GS) and glutamine synthase (GOGAT) to the ammonia assimilation, while it increased the content of free amino acids and decreased that of soluble protein as well.	Nitrates	123-130	inducible nitrate reductase [NADH] 1	Glycine max	142-144
17307929-6	2007	In seedlings grown under uninoculated conditions supplied with nitrate, nup85 did not arrest plant growth but significantly reduced seed production.	Nitrates	63-70	NUP85	Lotus japonicus	72-77
17162569-4	2007	Comparison of the PAH degradation rates under three reducing conditions showed the following order: sulfate-reducing conditions &gt; methanogenic conditions &gt; nitrate-reducing conditions.	Nitrates	162-169	phenylalanine hydroxylase	Homo sapiens	18-21
17162569-6	2007	However, the addition of acetate, lactate or pyruvate inhibited PAH degradation under nitrate-reducing conditions.	Nitrates	86-93	phenylalanine hydroxylase	Homo sapiens	64-67
17470441-2	2007	Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes.	Nitrates	51-58	nitrate reductase 1	Arabidopsis thaliana	68-85
17470441-2	2007	Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes.	Nitrates	51-58	nitrate reductase 1	Arabidopsis thaliana	87-89
17470441-2	2007	Initial experiments in the late 1950s showing that nitrate enhances nitrate reductase (NR) activity after several hours of treatment have now progressed to transcriptome studies identifying over 1000 genes that respond to muM levels of nitrate within minutes.	Nitrates	68-75	nitrate reductase 1	Arabidopsis thaliana	87-89
17470441-3	2007	The use of an Arabidopsis NR-null mutant allowed the identification of genes that respond to nitrate when the production of downstream metabolites of nitrate is blocked.	Nitrates	93-100	nitrate reductase 1	Arabidopsis thaliana	26-28
17470441-3	2007	The use of an Arabidopsis NR-null mutant allowed the identification of genes that respond to nitrate when the production of downstream metabolites of nitrate is blocked.	Nitrates	150-157	nitrate reductase 1	Arabidopsis thaliana	26-28
17470441-6	2007	Most of these genes and pathways are ones that were identified using the NR-null mutant as responding directly to nitrate.	Nitrates	114-121	nitrate reductase 1	Arabidopsis thaliana	73-75
17578866-7	2007	It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	30-38
17578866-7	2007	It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation.	Nitrates	60-67	nitrate transporter 1.1	Arabidopsis thaliana	40-44
17578866-7	2007	It has been reported that the AtNRT1.1 (CHL1) dual-affinity nitrate transporter acts upstream of the ANR1 MADS box gene in mediating the stimulatory effect of a localized nitrate supply on lateral root proliferation.	Nitrates	60-67	AGAMOUS-like 44	Arabidopsis thaliana	101-105
17220512-9	2007	The enzyme activity of glucose 6-phosphate dehydrogenase (G6PDH), the enzyme supporting the first step of the OPPP, was induced by external nitrate supply.	Nitrates	140-147	glucose-6-phosphate dehydrogenase	Homo sapiens	58-63
17192887-7	2007	DMH-induced increases in the total nitrite/nitrate levels and the nitric oxide synthase (NOS) activity (n = 10-12, P &lt; 0.05) were also reduced in the DMH + GM-CSF group (n = 8-9, P &lt; 0.05).	Nitrates	43-50	colony stimulating factor 2	Rattus norvegicus	159-165
17393066-1	2007	The study aimed to assay the cerebrospinal fluid (CSF) levels of protein S100B, a biomarker of astrocyte activation in relation to kynurenic acid (KYNA) and nitric oxide (NO) metabolites, nitrate/nitrite (NOx) concentrations in acute relapse multiple sclerosis (MS) patients.	Nitrates	188-195	S100 calcium binding protein B	Homo sapiens	73-78
17109653-8	2006	prevented hypertension-induced attenuation of acetylcholine-induced endothelium-dependent relaxation, impairment of vascular endothelial lining, decrease in expression of mRNA for endothelial nitric oxide synthase (eNOS), serum nitrite/nitrate concentration and increase in expression of mRNA for p22phox, superoxide anion and serum TBARS.	Nitrates	236-243	nitric oxide synthase 3	Rattus norvegicus	215-219
17085507-7	2007	Disruption of NRT2.2 in Atnrt2.2 reduced IHATS by 19% and this reduction was statistically significant only at 6 h after resupply of nitrate to nitrogen-deprived plants.	Nitrates	133-140	nitrate transporter 2:1	Arabidopsis thaliana	14-18
17085507-7	2007	Disruption of NRT2.2 in Atnrt2.2 reduced IHATS by 19% and this reduction was statistically significant only at 6 h after resupply of nitrate to nitrogen-deprived plants.	Nitrates	133-140	nitrate transporter 2:1	Arabidopsis thaliana	24-30
17148611-0	2006	The Arabidopsis NRT1.1 transporter participates in the signaling pathway triggering root colonization of nitrate-rich patches.	Nitrates	105-112	nitrate transporter 1.1	Arabidopsis thaliana	16-20
16510147-9	2006	Interestingly, some medications taken by the patients (e.g. diuretics and short-acting nitrates) might affect plasma eotaxin levels.	Nitrates	87-95	C-C motif chemokine ligand 11	Homo sapiens	117-124
17153996-2	2006	The higher content of NO3- in groundwater compared to surface water during both summer and winter seasons indicates that the karstic groundwater system cannot easily recover once contaminated with nitrate.	Nitrates	197-204	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
17304849-1	2006	PBS, a new kind of biodegradable polymers (BDPs), can be used as carbon source and biofilm carrier to remove nitrate from drinking water source.	Nitrates	109-116	translocator protein	Homo sapiens	0-3
17304849-4	2006	Influent nitrate concentration (53 mg x L- 1) can be reduced to less than 10 mg x L(-1) within 12 h. The IR spectrum showed that under development of denitrifying biofilm, absorption band at 2 925 cm(-1),2 850 cm(-1), 3200 cm(-1) -3410 cm-1 became weak, which suggested that the content of methyl or hydroxyl group in PBS decreased slightly, and the other functional groups were not influenced apparently.	Nitrates	9-16	translocator protein	Homo sapiens	318-321
17153996-5	2006	Combined with information on NO3- /Cl-, the variations of the isotope values of nitrate in the groundwater show a mixing process of multiple sources of nitrate, especially in the summer season.	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
17092343-2	2006	According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the development of nitrate and cross-tolerance.	Nitrates	99-106	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	166-172
17060777-11	2006	Conversely, urinary nitrate levels indicative of vascular e-NOS activity remained significantly and persistently higher in MP-treated animals (P &lt; 0.05).	Nitrates	20-27	nitric oxide synthase 3	Sus scrofa	58-63
17092343-2	2006	According to recent studies, mitochondrial ROS formation and oxidative inactivation of the organic nitrate bioactivating enzyme mitochondrial aldehyde dehydrogenase (ALDH-2) play an important role for the development of nitrate and cross-tolerance.	Nitrates	220-227	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	166-172
17345786-12	2006	Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate.	Nitrates	81-88	angiogenin	Rattus norvegicus	147-155
17132443-7	2006	Nitrate concentration, mg [N]/kg [dry soil], is estimated using the FT-IR/ATR spectrum of this second paste.	Nitrates	0-7	ATR serine/threonine kinase	Homo sapiens	68-77
17132443-2	2006	Several studies have shown that Fourier transform infrared attenuated total reflectance (FT-IR/ATR) spectroscopy could be used to estimate the nitrate content of standardized soil pastes.	Nitrates	143-150	ATR serine/threonine kinase	Homo sapiens	89-98
17132443-3	2006	Paste standardization appeared to be the main obstacle to in situ application of this approach, and the present study shows how FT-IR/ATR can be used to estimate both water content and nitrate concentration of field soil samples.	Nitrates	185-192	ATR serine/threonine kinase	Homo sapiens	128-137
17345786-12	2006	Olmesartan significantly improved cardiovascular remodeling and cardiac nitrite/ nitrate content, but co-administration of olmesartan and (D-Ala7)-Ang-(1-7) partially reversed this anti-remodeling effect and the increase in nitrite/nitrate.	Nitrates	232-239	angiogenin	Rattus norvegicus	147-155
16952382-8	2006	Moreover, hCG increased nitrate uptake into MLTC-1, which suggests the gonadotropin aids nitrite and nitrate ions in their steroidogenesis inhibitory activity.	Nitrates	24-31	hypertrichosis 2 (generalised, congenital)	Homo sapiens	10-13
17012411-9	2006	Plants resulting from a cross between both mutants (atnrt2.1-1 x atnar2.1-1) showed a phenotype like that of the atnar2.1-1 mutant when grown in 0.5 mm nitrate.	Nitrates	152-159	nitrate transporter 2:1	Arabidopsis thaliana	52-60
16952382-8	2006	Moreover, hCG increased nitrate uptake into MLTC-1, which suggests the gonadotropin aids nitrite and nitrate ions in their steroidogenesis inhibitory activity.	Nitrates	101-108	hypertrichosis 2 (generalised, congenital)	Homo sapiens	10-13
16968407-5	2006	In this context, we hypothesize that IL-10, through its ability to inhibit anti-leishmanial macrophage activation, associated with the lower frequency of TNF-alpha(+) monocytes and ordinary levels of nitrite and nitrate are the major mechanisms associated with disease onset.	Nitrates	212-219	interleukin 10	Homo sapiens	37-42
17043238-8	2006	Compared with wild-type microglia, mSOD1(G93A) microglia produced and released more superoxide and nitrite+nitrate, and induced more neuronal death.	Nitrates	107-114	superoxide dismutase 1, soluble	Mus musculus	35-40
16905358-2	2006	The first known member Nar1.1 encodes a chloroplast nitrite transporter that regulates nitrate assimilation according to carbon availability, and data supporting the idea that NAR1 proteins may participate in adjusting both nitrite and carbon utilization by Chlamydomonas cells are presented herein.	Nitrates	87-94	NAR1.1	Chlamydomonas reinhardtii	23-29
17035137-5	2006	Individual nitrate exposures from beverages prepared with tap water were calculated by linking the postal code of individual residence at baseline to water company data.	Nitrates	11-18	nuclear RNA export factor 1	Homo sapiens	58-61
16980702-3	2006	These results suggest that the replacement of Asp105 in AtNRT3.1 markedly reduces nitrate uptake and accumulation.	Nitrates	82-89	nitrate transmembrane transporter	Arabidopsis thaliana	56-64
17032626-7	2006	A positive correlation between NOx (nitrites and nitrates levels) and VEGF was found in healthy individuals (r = 0.55, p = 0.003), but there was no correlation in hypertensive patients.	Nitrates	49-57	vascular endothelial growth factor A	Homo sapiens	70-74
17000306-9	2006	The downregulated endothelial nitric oxide synthase level in the distended grafts was accompanied by a 45.2% +/- 3.1% reduction of phospho-endothelial nitric oxide synthase Ser1177 levels and by a significant reduction in nitric oxide synthase activity (12.1% +/- 1.2%) and nitrate production (48.9% +/- 5.6%) in comparison with that seen in drug-treated grafts.	Nitrates	274-281	nitric oxide synthase 3	Homo sapiens	18-51
16905358-4	2006	The expression patterns for Nar1 transcripts showed differential responses to changes in nitrogen or carbon status, as well as a particular regulation by the nitrate assimilation regulatory gene Nit2.	Nitrates	158-165	uncharacterized protein	Chlamydomonas reinhardtii	195-199
17003285-2	2006	LPS decreased IGF-I mRNA in hepatocyte cultures and increased the nitrite + nitrate levels in the culture medium.	Nitrates	76-83	interferon regulatory factor 6	Homo sapiens	0-3
16961492-1	2006	Because of the ubiquitous nature of anthropogenic nitrate (NO3(-)) in many parts of the world, determining background concentrations of NO3(-) in shallow ground water from natural sources is probably impossible in most environments.	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
18970764-7	2006	Nitrate was found being present at 4.79-5.99mug/mL in dew, 1.20-2.63mug/mL in rain, 0.32-0.60mug/mL in snow and 0.12-0.23mug/mL in lake water.	Nitrates	0-7	Ras interacting protein 1	Homo sapiens	78-82
16412539-4	2006	The nitrate accumulation was 20-50mg NO3-N day(-1)kg(-1) observed after methylene urea fertilization of 889 g Nm(-2).	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
17003285-6	2006	In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures.	Nitrates	160-167	nitric oxide synthase 2	Homo sapiens	26-47
17003285-6	2006	In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures.	Nitrates	160-167	nitric oxide synthase 2	Homo sapiens	49-53
17003285-3	2006	Furthermore, there was a negative correlation between the IGF-I mRNA and the nitrite+nitrate levels.	Nitrates	85-92	insulin like growth factor 1	Homo sapiens	58-63
17003285-6	2006	In addition, two specific inducible NO synthase (iNOS) inhibitors, l-N6-(1-iminoethyl)lysine (l-NIL) and aminoguanidine, prevented the effect of LPS on nitrite+nitrate levels and on IGF-I gene expression in hepatocyte cultures.	Nitrates	160-167	interferon regulatory factor 6	Homo sapiens	145-148
16434229-3	2006	Comparing with the calculated energies, it can be concluded that the syn conformers with Cs overall symmetry, a planar CC(O)ONO skeleton in nitrites, and a planar CC(O)ON skeleton in nitrates, respectively, are the most stable in the gas phase.	Nitrates	183-191	synemin	Homo sapiens	69-72
17003285-8	2006	However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression.	Nitrates	88-95	nitric oxide synthase 2	Homo sapiens	28-32
17003285-8	2006	However, in cocultures, the iNOS inhibitor l-NIL prevented the effect of LPS on nitrite+nitrate levels, but only attenuated the LPS-induced decrease in IGF-I gene expression.	Nitrates	88-95	interferon regulatory factor 6	Homo sapiens	73-76
16904722-11	2006	Nitro-group of PNP converted to nitrite and nitrate.	Nitrates	44-51	purine nucleoside phosphorylase	Homo sapiens	15-18
16906281-6	2006	Urinary nitrate (NO3) excretion was measured in 18 IDV-treated patients and compared with that of 8 patients treated with efavirenz, a drug without renal side effects.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
16600336-3	2006	The INCA-N model was able to simulate the seasonal and inter-annual variations in the stream-water nitrate concentrations, although the lowest concentrations during the growing season were not reproduced.	Nitrates	99-106	caspase recruitment domain family member 17	Homo sapiens	4-8
16618496-8	2006	For the only two tributaries of the Thames which we have monitored for over 5 years (the Pang and the Kennet), nitrate concentrations have increased over time.	Nitrates	111-118	contactin 3	Homo sapiens	89-93
16618496-10	2006	As the Pang and the Kennet river water is mainly supplied from the Chalk, the increasing nitrate concentrations over time clearly reflect increasing nitrate concentrations within the groundwater.	Nitrates	89-96	contactin 3	Homo sapiens	7-11
16618496-10	2006	As the Pang and the Kennet river water is mainly supplied from the Chalk, the increasing nitrate concentrations over time clearly reflect increasing nitrate concentrations within the groundwater.	Nitrates	149-156	contactin 3	Homo sapiens	7-11
16891913-0	2006	Ramipril treatment protects against nitrate-induced oxidative stress in eNOS-/- mice: An implication of the NADPH oxidase pathway.	Nitrates	36-43	nitric oxide synthase 3, endothelial cell	Mus musculus	72-79
16878138-0	2006	The nitrate/proton antiporter AtCLCa mediates nitrate accumulation in plant vacuoles.	Nitrates	4-11	chloride channel A	Arabidopsis thaliana	30-36
16878138-6	2006	We demonstrate that AtCLCa is able to accumulate specifically nitrate in the vacuole and behaves as a NO3-/H+ exchanger.	Nitrates	62-69	chloride channel A	Arabidopsis thaliana	20-26
16937444-7	2006	In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis.	Nitrates	188-196	growth hormone 1	Homo sapiens	44-46
16937444-7	2006	In addition, L-NAME was able to inhibit the GH-effects on intracellular cAMP concentration under basal conditions and in response to CT. GH induced a Ca(2+)-dependent increase of nitrites/nitrates production, indicating the involvement of the constitutive rather than the inducible NOS isoform, which was directly confirmed by Western blot analysis.	Nitrates	188-196	growth hormone 1	Homo sapiens	137-139
16705756-4	2006	Nitrite plus nitrate levels were lower in iNOS(-/-) compared with iNOS(+/+) mice, but CCl(4) did not produce a significant effect in any mice.	Nitrates	13-20	nitric oxide synthase 2, inducible	Mus musculus	42-46
16777528-7	2006	Thus, in cucumber, NR and GS expression appear to be dominated by sugar levels, rather than by nitrate contents.	Nitrates	95-102	nitrate reductase [NADH]-like	Cucumis sativus	19-21
16683800-4	2006	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water.	Nitrates	157-164	secreted phosphoprotein 1	Homo sapiens	177-181
16929648-6	2006	The results suggest that methanogen, sulfate-reducing bacteria, and nitrate-reducing bacteria all are involved in the dechlorination of PCB congeners.	Nitrates	68-75	pyruvate carboxylase	Homo sapiens	136-139
16830541-5	2006	Under the hypotheses of no interaction and absence of mutual screening of radiation, nitrate would prevail over DOM as *OH source for a NO3-/DOM ratio higher than 3.3 x 10(-5) (mol NO3-) (mg C)(-1), DOM prevailing for lower values.	Nitrates	85-92	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
16448661-1	2006	The adsorption of Co2+ ions from nitrate solutions using iron oxide nanoparticles of magnetite (Fe3O4) and maghemite (gamma-Fe2O3) has been studied.	Nitrates	33-40	complement C2	Homo sapiens	18-21
16683800-4	2006	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water.	Nitrates	157-164	DNA polymerase iota	Homo sapiens	219-223
16683800-4	2006	According to pointwise thermodynamic integration involving constrained molecular dynamics simulations, solvation facilitates the transition of the chelating nitrate ligand to a eta1-bonding mode: the free energy of UO2(eta2-NO3)(eta1-NO3)(OH2)2 relative to the bis-chelating minimum drops from 3.9 kcal/mol in vacuo to 1.4 kcal/mol in water.	Nitrates	157-164	secreted phosphoprotein 1	Homo sapiens	229-233
16527817-0	2006	Characterization of the mechanism of cytochrome P450 reductase-cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates.	Nitrates	142-150	cytochrome p450 oxidoreductase	Homo sapiens	37-62
16527817-1	2006	Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown.	Nitrates	99-106	cytochrome p450 oxidoreductase	Homo sapiens	10-35
16527817-1	2006	Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown.	Nitrates	99-106	cytochrome p450 oxidoreductase	Homo sapiens	37-40
16527817-1	2006	Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown.	Nitrates	175-182	cytochrome p450 oxidoreductase	Homo sapiens	10-35
16527817-1	2006	Mammalian cytochrome P450 reductase (CPR) and cytochrome P450 (CP) play important roles in organic nitrate bioactivation; however, the mechanism by which they convert organic nitrate to NO remains unknown.	Nitrates	175-182	cytochrome p450 oxidoreductase	Homo sapiens	37-40
16527817-3	2006	To characterize the mechanism of CPR-CP-mediated organic nitrate bioactivation, EPR, chemiluminescence NO analyzer, NO electrode, and immunoassay studies were performed.	Nitrates	57-64	cytochrome p450 oxidoreductase	Rattus norvegicus	33-36
16527817-4	2006	With rat hepatic microsomes or purified CPR, the presence of NADPH triggered organic nitrate reduction to NO2(-).	Nitrates	85-92	cytochrome p450 oxidoreductase	Rattus norvegicus	40-43
16527817-7	2006	Therefore, CPR catalyzes organic nitrate reduction, producing nitrite, whereas CP can mediate further nitrite reduction to NO.	Nitrates	33-40	cytochrome p450 oxidoreductase	Homo sapiens	11-14
16527817-8	2006	Nitrite-dependent NO generation contributed &lt;10% of the CPR-CP-mediated NO generation from organic nitrates; thus, NO2(-) is not the main precursor of NO.	Nitrates	102-110	cytochrome p450 oxidoreductase	Rattus norvegicus	59-62
16527817-10	2006	Studies suggested that organic nitrite (R-O-NO) was produced from organic nitrate reduction by CPR.	Nitrates	74-81	cytochrome p450 oxidoreductase	Homo sapiens	95-98
16636306-5	2006	Treatment with two structurally dissimilar iNOS inhibitors at doses sufficient to decrease urine nitrate and/or nitrite exacerbated proteinuria.	Nitrates	97-104	nitric oxide synthase 2	Rattus norvegicus	43-47
16719098-0	2006	Regional patterns in the isotopic composition of natural and anthropogenic nitrate in groundwater, High Plains, U.S.A. Mobilization of natural nitrate (NO3-) deposits in the subsoil by irrigation water in arid and semiarid regions has the potential to produce large groundwater NO3-concentrations.	Nitrates	143-150	NBL1, DAN family BMP antagonist	Homo sapiens	152-155
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrates	4-11	glutathione S-transferase kappa 1	Homo sapiens	132-157
16632127-9	2006	A line of evidence including inhibitor studies, EPR spectroscopy, and nitrite/nitrate detection identifies catalase as a possible oxidant for the conversion of hydroxyurea to NO.	Nitrates	78-85	catalase	Rattus norvegicus	107-115
16634581-13	2006	The coordination environment around the bridging Co(II) ion contains four oxygen (two P-O units, one chelating nitrate) and two nitrogen atoms (pyridyloxy nitrogens).	Nitrates	111-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55
16424150-7	2006	The cytosolic GST-mediated denitration of these organic nitrates in liver limits their interaction with other intracellular compartments to possible generation of NO and/or their subsequent availability and bioactivation in the systemic circulation and extrahepatic tissues.	Nitrates	56-64	glutathione S-transferase kappa 1	Homo sapiens	14-17
16424150-3	2006	The nitrate moiety of this latter is subsequently metabolized to inorganic nitrogen oxides (NOx), predominantly in liver cytosol by glutathione S-transferase (GST) and to a lesser extent in liver mitochondria.	Nitrates	4-11	glutathione S-transferase kappa 1	Homo sapiens	159-162
16524873-5	2006	In nodules of Asppc plants, PEPC activity was reduced to about 10% of that of non-transformants and the plants showed typical nitrogen-deficient symptoms without a supply of nitrogen nutrient, and returned to normal growth when nitrate was supplied at 2.5 mM.	Nitrates	228-235	LjPEPC1	Lotus japonicus	28-32
16609365-0	2006	A -786T&gt;C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine.	Nitrates	94-101	nitric oxide synthase 3	Homo sapiens	33-66
16680018-12	2006	The increase in plasma concentration of nitrate and nitrite was inhibited by BBS-2.	Nitrates	40-47	Bardet-Biedl syndrome 2 protein	Ovis aries	77-82
16543501-4	2006	Relative to data in control rats, arteries from Adv-CYP4A2-transduced rats produced more 20-HETE (129+/-10 versus 97+/-7 pmol/mg protein, P&lt;0.01) and less nitric oxide (NO; 4.2+/-1.6 versus 8.4+/-1 nmol nitrite+nitrate/mg; P&lt;0.05).	Nitrates	214-221	cytochrome P450, family 4, subfamily a, polypeptide 2	Rattus norvegicus	52-58
16417494-4	2006	A total of 51 operons were directly or indirectly activated by NarL in response to nitrate; a further 41 operons were repressed.	Nitrates	83-90	DNA-binding transcriptional dual regulator NarL	Escherichia coli str. K-12 substr. MG1655	63-67
16545248-6	2006	The concentration of MPO was correlated with the concentrations of 8-isoprostane and nitrate, which were normalized to the nitrite concentration.	Nitrates	85-92	myeloperoxidase	Homo sapiens	21-24
16415212-0	2006	High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1.	Nitrates	14-21	nitrate transmembrane transporter	Arabidopsis thaliana	100-108
16415212-3	2006	AtNRT3.1 accounts for greater than 99% of NRT3 mRNA and is induced 6-fold by nitrate.	Nitrates	77-84	nitrate transmembrane transporter	Arabidopsis thaliana	0-8
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	0-7	nitrate transporter 1.1	Arabidopsis thaliana	51-59
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	0-7	nitrate transporter 2:1	Arabidopsis thaliana	64-72
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	0-7	nitrate transmembrane transporter	Arabidopsis thaliana	88-96
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	25-32	nitrate transporter 1.1	Arabidopsis thaliana	51-59
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	25-32	nitrate transporter 2:1	Arabidopsis thaliana	64-72
16415212-6	2006	Nitrate induction of the nitrate transporter genes AtNRT1.1 and AtNRT2.1 was reduced in Atnrt3.1 mutant plants, and this reduced expression was correlated with reduced nitrate concentrations in the tissues.	Nitrates	25-32	nitrate transmembrane transporter	Arabidopsis thaliana	88-96
16415212-7	2006	Constitutive high-affinity influx was reduced by 34% and 89%, respectively, in Atnrt3.1-1 and Atnrt3.1-2 mutant plants, while high-affinity nitrate-inducible influx was reduced by 92% and 96%, respectively, following induction with 1 mm KNO(3) after 7 d of nitrogen deprivation.	Nitrates	140-147	nitrate transmembrane transporter	Arabidopsis thaliana	94-102
16471967-13	2006	In 11 (L10 and NO3-), the nitrate acts as a bidentate ligand and an [Ag-NO3-]infinity chain is formed.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	15-18
16471967-13	2006	In 11 (L10 and NO3-), the nitrate acts as a bidentate ligand and an [Ag-NO3-]infinity chain is formed.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	72-75
16673818-5	2006	When the initial nitrate concentration was 30.2 mg NO3- -N / L, the denitrification efficiency was 57.3% at an applied electric current of 15 mA and a hydraulic retention time (HRT) of 12 hours.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
16673818-7	2006	The nitrate removal rate of the reactor was 34.4 g NO3- -N/m3 x d, and the surface area loading was 1.34 g NO3- -N / m2 x d. CONCLUSION: The coated electrode may keep high quantity of biomass, thus achieving a high denitrification rate.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
16673818-7	2006	The nitrate removal rate of the reactor was 34.4 g NO3- -N/m3 x d, and the surface area loading was 1.34 g NO3- -N / m2 x d. CONCLUSION: The coated electrode may keep high quantity of biomass, thus achieving a high denitrification rate.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
16496123-10	2006	Both the reduction in plasma nitrate and nitrite and the elevation in aortic superoxide associated with STZ diabetes were normalised with VEGF treatment.	Nitrates	29-36	vascular endothelial growth factor A	Rattus norvegicus	138-142
16556209-9	2006	In an example application, we used all models to reanalyze a published PPT data set to obtain k estimates for nitrate consumption in a petroleum-contaminated aquifer.	Nitrates	110-117	tachykinin precursor 1	Homo sapiens	71-74
16417494-6	2006	Global repression by the nitrate- and nitrite-responsive two-component system, NarQ-NarP, was shown for the first time.	Nitrates	25-32	DNA-binding transcriptional dual regulator NarP	Escherichia coli str. K-12 substr. MG1655	84-88
16523632-2	2006	The half-life of NO averages only 3 to 4 s in biological fluids, where it is rapidly converted to the stable oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	147-154	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
16495753-1	2006	The present study was designed to determine if endogenous calcitonin gene-related peptide (CGRP) affects the process of nitrate tolerance development in blood vessels.	Nitrates	120-127	calcitonin-related polypeptide alpha	Rattus norvegicus	91-95
16686191-1	2006	PBS, a new kind of biodegradable polymers (BDPs), was used as carbon source and biofilm carrier to remove nitrate from drinking water.	Nitrates	106-113	cholinergic receptor muscarinic 3	Homo sapiens	0-3
16331442-5	2006	The TOX method is moderately sensitive to nitrate rinse volume.	Nitrates	42-49	thymocyte selection associated high mobility group box	Homo sapiens	4-7
16223957-5	2006	Inhibition of cellular nitrate/nitrite synthesis in RAW, rat mesangium, and human embryonic kidney 293 cells after iNOS induction showed 40- to 100-fold higher IC(50) values than at the isolated enzyme, in agreement with the much higher l-arginine concentrations in cell culture media and inside intact cells.	Nitrates	23-30	nitric oxide synthase 2	Homo sapiens	115-119
16391109-0	2006	Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1.	Nitrates	56-63	nitrite extrusion protein 1	Pseudomonas aeruginosa PAO1	15-20
16391109-0	2006	Involvement of NarK1 and NarK2 proteins in transport of nitrate and nitrite in the denitrifying bacterium Pseudomonas aeruginosa PAO1.	Nitrates	56-63	nitrite extrusion protein 2	Pseudomonas aeruginosa PAO1	25-30
16391109-1	2006	Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa.	Nitrates	168-175	nitrite extrusion protein 1	Pseudomonas aeruginosa PAO1	58-63
16391109-1	2006	Two transmembrane proteins were tentatively classified as NarK1 and NarK2 in the Pseudomonas genome project and hypothesized to play an important physiological role in nitrate/nitrite transport in Pseudomonas aeruginosa.	Nitrates	168-175	nitrite extrusion protein 2	Pseudomonas aeruginosa PAO1	68-73
16739926-4	2006	It has very short life span and is converted into nitrites (NO2-) and nitrates (NO3-).	Nitrates	70-78	NBL1, DAN family BMP antagonist	Homo sapiens	80-83
16739926-6	2006	Prior determination of NO2-/NO3- the nitrates were reduced to nitrites with zinc, and total level of NO2- was detected by Griess reaction.	Nitrates	37-45	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
16720601-8	2006	However, the vtc2 mutants produced greater numbers of longer LRs than wild-type or vtc1 plants at all levels of nitrate.	Nitrates	112-119	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	13-17
16095667-8	2006	It was concluded that long-term exposure to high nitrate intake by drinking water and home made meals from local products results in increased thyroid volume and increased frequency of signs of subclinical thyroid disorders (thyroid hypoechogenicity by ultrasound, increased TSH level and positive anti-TPO).	Nitrates	49-56	thyroid peroxidase	Homo sapiens	303-306
16800771-10	2006	In vivo mechanistic studies with BRBs indicate that they reduce the growth rate of premalignant esophageal cells, in part, through down-regulation of cyclooxygenase-2 leading to reduced prostaglandin production and of inducible nitric oxide synthase leading to reduced nitrate/nitrite levels in the esophagus.	Nitrates	269-276	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-166
16532746-7	2006	The oxygen/nitrate return sludge model block predicts a 10% improvement of N removal performance under dynamic conditions, and might be the better modelling option for ASM1 plants: it is computationally more efficient and it will not overrate the importance of decay processes in the settler.	Nitrates	11-18	H19 imprinted maternally expressed transcript	Homo sapiens	168-172
16367968-5	2006	The seedling phenotype of vp10 mutants is consistent with disruptions in ABA and auxin biosynthesis, as well as a disruption in nitrate metabolism.	Nitrates	128-135	viviparous10	Zea mays	26-30
16452058-11	2006	Fucoidin caused an increase in the fractional excretion of nitrates, a response accompanied by increased iNOS mRNA.	Nitrates	59-67	nitric oxide synthase 2	Rattus norvegicus	105-109
23074496-6	2006	CONVENTIONAL APPROACHES TO RESTORING THE BALANCE BETWEEN OXYGEN SUPPLY AND DEMAND FOCUS ON THE DISRUPTION OF THE UNDERLYING DISEASE THROUGH: drug therapy (beta blockers, calcium channel blockers, nitrates, antiplatelet agents, ACE inhibitors, statins); life-style modifications (smoking cessation, weight loss); or revascularization techniques such as coronary artery bypass graft surgery (CABG) or percutaneous coronary interventions (PCI).	Nitrates	196-204	angiotensin I converting enzyme	Homo sapiens	227-230
16387564-1	2005	Phosphodiesterase 5 (PDE5) inhibitors have modest nitrate-like hemodynamic effects, lowering wedge pressure, pulmonary artery pressure, and systolic and diastolic arterial pressure.	Nitrates	50-57	phosphodiesterase 5A	Homo sapiens	0-19
16387564-1	2005	Phosphodiesterase 5 (PDE5) inhibitors have modest nitrate-like hemodynamic effects, lowering wedge pressure, pulmonary artery pressure, and systolic and diastolic arterial pressure.	Nitrates	50-57	phosphodiesterase 5A	Homo sapiens	21-25
16387566-5	2005	The duration of interaction between a PDE5 inhibitor and nitrate administration depends on the specific drug being studied.	Nitrates	57-64	phosphodiesterase 5A	Homo sapiens	38-42
16387572-6	2005	The emergency physician needs to have evidence-based guidance on how best to treat patients with potential ACS who are being treated for ED, how much time must elapse between the last dose of phosphodiesterase 5 (PDE5) inhibitor and treatment with nitrates, and how to modify treatment of patients with ACS when patients have recently used a PDE5 inhibitor.	Nitrates	248-256	phosphodiesterase 5A	Homo sapiens	342-346
16387572-7	2005	Additionally, patients who have been prescribed a PDE5 inhibitor should be educated on the use of nitrates and the need to inform physicians about the use of PDE5 inhibitors during all encounters so that risk can be minimized.	Nitrates	98-106	phosphodiesterase 5A	Homo sapiens	50-54
16235022-0	2005	The mobA gene is required for assimilatory and respiratory nitrate reduction but not xanthine dehydrogenase activity in Pseudomonas aeruginosa.	Nitrates	59-66	MobA mobilisation protein	Pseudomonas aeruginosa	4-8
16235022-4	2005	Regulation studies using a Phi(PA3030-lacZGm) reporter strain suggest that expression of mobA is not influenced by the type of nitrogen source or by anaerobiosis, whereas assimilatory nitrate reductase activity was detected only in the presence of nitrate.	Nitrates	184-191	reductase	Pseudomonas aeruginosa PAO1	192-201
16006543-6	2005	Nitrate/nitrite plasma levels of Hct-augmented hamsters increased relative to control and L-NAME treated animals.	Nitrates	0-7	hair constriction	Mus musculus	33-36
16199562-2	2005	Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite.	Nitrates	206-213	napF	Haemophilus influenzae Rd KW20	51-55
16269753-5	2005	Additional experiments revealed that the level of tceA expression was independent of the concentration of chlorinated ethenes (sum concentrations of TCE and DCEs of 2.2 to 333 microM), the concentration of the electron donor hydrogen (concentrations of 12 nM to 17 microM), and the presence of alternate bacterial electron acceptors (5 mM concentrations of fumarate, sulfate, sulfite, thiosulfate, nitrate, or nitrite) but was highly dependent on incubation temperature.	Nitrates	398-405	transcription elongation factor A1	Homo sapiens	50-54
16307975-8	2005	Our results showed that diabetic rats were associated with increased 8-OHdG, IL-6, and ET-1 decreased [nitrate+nitrite].	Nitrates	103-110	endothelin 1	Rattus norvegicus	87-91
16214035-2	2005	Through a metabonomics approach termed "NObonomics," the effects of a prototypic NO donor (organic nitrate)-cyclooxygenase-2 inhibitor hybrid (NO-coxib), NMI-1093, on the NO metabolite status of the circulation and major organs have been profiled in vivo in the rat.	Nitrates	99-106	prostaglandin-endoperoxide synthase 2	Homo sapiens	108-124
16262716-0	2005	Genetic analysis of Arabidopsis GATA transcription factor gene family reveals a nitrate-inducible member important for chlorophyll synthesis and glucose sensitivity.	Nitrates	80-87	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	32-36
16262716-8	2005	A transcript profiling experiment revealed that a considerable proportion of genes downregulated in the loss-of-function mutants are involved in carbon metabolism and At5g56860 is thus designated GNC (GATA, nitrate-inducible, carbon metabolism-involved).	Nitrates	207-214	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	196-199
16189417-6	2005	Furthermore, STAT-6 mice receiving DSS had dramatically higher levels of serum nitrite/nitrate than all other groups.	Nitrates	87-94	signal transducer and activator of transcription 6	Mus musculus	13-19
16199562-2	2005	Transcription initiation from the Escherichia coli napF operon control region is activated by the Fnr protein in response to anaerobiosis and by the NarQ-NarP two-component regulatory system in response to nitrate or nitrite.	Nitrates	206-213	response regulator	Haemophilus influenzae Rd KW20	154-158
16199562-8	2005	By contrast, expression from the H. influenzae napF-lacZ operon fusion in E. coli was stimulated equally well by nitrate in both narP and narL null mutants, indicating that phospho-NarL and -NarP are equally effective regulators of this promoter.	Nitrates	113-120	napF	Haemophilus influenzae Rd KW20	47-51
16157886-5	2005	NRT2.1 encodes a putative high-affinity nitrate transporter that functions at low external nitrate concentrations.	Nitrates	40-47	nitrate transporter 2:1	Arabidopsis thaliana	0-4
16408766-7	2005	Recent studies indicate that the alternations of PKG expression and activity are closely related with the pathogenesis of atherosclerosis, restenosis, hypertension, hyperlipemia as well as nitrate tolerance.	Nitrates	189-196	protein kinase cGMP-dependent 1	Homo sapiens	49-52
16156615-4	2005	IR and Raman analyses of 11a and 12a were performed to determine the coordination behavior of the nitrate counteranion, and it was found that both NO3- and H2O coordinate to the metal centers.	Nitrates	98-105	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	phytosulfokine 1 precursor	Arabidopsis thaliana	80-84
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	COP1-interacting protein 8	Arabidopsis thaliana	86-90
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	GRAS family transcription factor	Arabidopsis thaliana	92-96
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	GRAS family transcription factor family protein	Arabidopsis thaliana	176-180
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	NADPH-dependent thioredoxin reductase A	Arabidopsis thaliana	206-210
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	sugar transporter 1	Arabidopsis thaliana	228-232
16212609-9	2005	A significant number of the responding genes are known to regulate light (PHYA, PSK1, CIP8, PAT1, APRR), auxin (Aux/IAA), ethylene (ETR2, EIN3, ERFs/EREBPs), gibberellin (GAI, RGA1, GA20 oxidase), nitrate (NTR2, NIA) and sugar (STP1, SUS1) dependent processes, indicating intense crosstalk with environmental cues, other hormones and metabolites.	Nitrates	197-204	sucrose synthase 1	Arabidopsis thaliana	234-238
16157886-8	2005	Furthermore, lateral root initiation is increased in lin1 relative to WT even when seedlings are grown on nitrate-free media, suggesting that the mutant phenotype is nitrate-independent.	Nitrates	106-113	nitrate transporter 2:1	Arabidopsis thaliana	53-57
16157886-8	2005	Furthermore, lateral root initiation is increased in lin1 relative to WT even when seedlings are grown on nitrate-free media, suggesting that the mutant phenotype is nitrate-independent.	Nitrates	166-173	nitrate transporter 2:1	Arabidopsis thaliana	53-57
16157886-10	2005	We propose that Arabidopsis NRT2.1 acts either as a nitrate sensor or signal transducer to coordinate the development of the root system with nutritional cues.	Nitrates	52-59	nitrate transporter 2:1	Arabidopsis thaliana	28-32
16157886-6	2005	Direct measurement of nitrate uptake and nitrate content in the lin1 mutant seedlings established that both are indeed reduced.	Nitrates	22-29	nitrate transporter 2:1	Arabidopsis thaliana	64-68
16157886-6	2005	Direct measurement of nitrate uptake and nitrate content in the lin1 mutant seedlings established that both are indeed reduced.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	64-68
16191399-5	2005	"Early entry" therapy with nitrates do not significantly improve survival in myocardial infarction but increases the beneficial effects of the ACE-inhibitor enalapril by 50%.	Nitrates	27-35	angiotensin I converting enzyme	Homo sapiens	143-146
15886273-10	2005	The protective effects of kallikrein were accompanied by increased urinary nitrate/nitrite and cGMP levels, and suppression of superoxide formation.	Nitrates	75-82	kallikrein related peptidase 4	Homo sapiens	26-36
16139272-5	2005	These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway.	Nitrates	32-40	angiotensinogen	Rattus norvegicus	25-31
16139272-5	2005	These data indicate that Ang II nitrates and activates ERK1/2 via a reactive species-sensitive pathway.	Nitrates	32-40	mitogen activated protein kinase 3	Rattus norvegicus	55-61
16392746-0	2005	Regulation of glutamine synthetase and glutamate dehydrogenase in pea mutants rrrbrb, rrRbRb, and RRrbrb during nitrate nitrogen assimilation.	Nitrates	112-119	glutamate-ammonia ligase	Homo sapiens	14-34
16133968-10	2005	The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression.	Nitrates	22-29	tumor necrosis factor	Rattus norvegicus	72-81
16051882-3	2005	Recent animal data suggest that mitochondrial aldehyde dehydrogenase (ALDH2) plays a central role in nitrate bioactivation, but its role in humans is not known.	Nitrates	101-108	aldehyde dehydrogenase 2 family member	Homo sapiens	70-75
16133968-10	2005	The downregulation of nitrate/nitrite by these inhibitors suggests that TNF-alpha modulates iNOS expression.	Nitrates	22-29	nitric oxide synthase 2	Rattus norvegicus	92-96
16078689-1	2005	A fast and highly sensitive ion chromatographic method using monolithic ODS columns was developed for the determination of nitrite (NO2-) and nitrate (NO3-) in seawater.	Nitrates	142-149	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
16148069-5	2005	We synthesized a novel organic nitrate [ethyl nitrate (ENO2)], tested it in vitro, and administered it to hypoxic piglets.	Nitrates	31-38	enolase 2	Homo sapiens	55-59
15950430-4	2005	Low concentrations of TNFalpha caused luteolysis, which resulted in a decreased level of P4, and increased levels of PGF2alpha, LTC4 and nitrite/nitrate (stable metabolites of nitric oxide-NO) in the blood.	Nitrates	145-152	tumor necrosis factor	Bos taurus	22-30
16007000-1	2005	OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations.	Nitrates	135-143	nitric oxide synthase 3	Homo sapiens	77-110
16187580-4	2005	Results are reported here from a study designed to investigate the efficiency of deionized water extraction of aerosol nitrate (NO3-) and sulfate from nylon filters.	Nitrates	119-126	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
16005970-1	2005	In recent years, nitrate (NO3) contamination of groundwater has become a growing concern for people in rural areas in North China Plain (NCP) where groundwater is used as drinking water.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
16007000-1	2005	OBJECTIVES: Controversy exists regarding the effects of polymorphisms in the endothelial nitric oxide synthase (eNOS) gene on nitrites/nitrates (NOx) plasma concentrations.	Nitrates	135-143	nitric oxide synthase 3	Homo sapiens	112-116
15998848-7	2005	Rates of nitrate removal, determined from the ratio of NO3-N to Br and ground water flow, averaged 1.4 g N m(-3) of wall d(-1) and were markedly greater than denitrification rates determined using the acetylene block technique (average: 0.11 g N m(-3) of wall d(-1)).	Nitrates	9-16	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
16180687-2	2005	The mean contents of nitrate were 0.73 +/- 14.57 mg/100 g, 0.61 +/- 1.12 mg/100 g and 0.25 +/- 0.33 mg/100 g as NO3-, respectively.	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	112-115
15998850-8	2005	Nitrate reduction by FeO was rapid and characterized by nearly stoichiometric conversion of NO3- to NH4+.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
15622524-5	2005	The appearance of iNOS expression correlates with increased levels of nitrite + nitrate levels and appearance of mitochondrial damage detected either at morphological and biochemical level.	Nitrates	80-87	nitric oxide synthase 2	Rattus norvegicus	18-22
16013860-5	2005	The disposable sensor responds to nitrate rapidly-the typical response time is 5 min-and reversibly over a wide dynamic range (26 microM-63 mM) with sensor-to-sensor reproducibility (relative standard deviation, RSD, 3.68%, as log aNO3-, at the medium level of the range and RSD 1.39% for repeated measurements with the same sensor).	Nitrates	34-41	anoctamin 3	Homo sapiens	231-235
16422846-0	2005	Successful withdrawal of oral long-acting nitrates to facilitate phosphodiesterase type 5 inhibitor use in stable coronary disease patients with erectile dysfunction.	Nitrates	42-50	phosphodiesterase 5A	Homo sapiens	65-89
16440845-6	2005	In nitrate treated animals, the weight of thyroid gland was increased significantly (P&lt;0.001) while thyroid peroxidase activity (P&lt;0.01), serum T4 (P&lt;0.01) and serum T3 levels (P&lt;0.001) were reduced; but serum TSH level was increased (P&lt;0.001) along with slightly elevated iodine excretion level (P&lt;0.001) in comparison to control animals.	Nitrates	3-10	thyroid peroxidase	Homo sapiens	103-121
16422846-2	2005	Phosphodiesterase type 5 (PDE5) inhibitors are effective in up to 80% of men but are contraindicated in the presence of oral nitrates, because of a potentially severe hypotensive interaction.	Nitrates	125-133	phosphodiesterase 5A	Homo sapiens	0-24
16422846-2	2005	Phosphodiesterase type 5 (PDE5) inhibitors are effective in up to 80% of men but are contraindicated in the presence of oral nitrates, because of a potentially severe hypotensive interaction.	Nitrates	125-133	phosphodiesterase 5A	Homo sapiens	26-30
16422846-5	2005	MAIN OUTCOME MEASURES: Discontinuation of oral nitrates to facilitate subsequent use of PDE5 therapy.	Nitrates	47-55	phosphodiesterase 5A	Homo sapiens	88-92
16422846-10	2005	Forty-nine of the 52 men no longer taking nitrates were treated with a PDE5 inhibitor which was effective in 22 out of 26 (85%) patients who have completed follow-up.	Nitrates	42-50	phosphodiesterase 5A	Homo sapiens	71-75
16422846-13	2005	CONCLUSION: Oral nitrates can be discontinued in the presence of continuing beta-blockade and/or calcium antagonist therapy in stable coronary disease patients with ED to allow for the safe use of PDE5 inhibitors.	Nitrates	17-25	phosphodiesterase 5A	Homo sapiens	197-201
15963975-3	2005	Coadministration of icatibant, a bradykinin B(2)-receptor antagonist (200 microg/kg/day), with enalapril blunted the stimulatory effect of the ACE inhibitor on eNOS mRNA expression, circulating levels of nitrite/nitrate, the relaxant activity of ACh and the release of 6-keto-PGF1alpha in L-NAME-treated rats.	Nitrates	212-219	angiotensin I converting enzyme	Rattus norvegicus	143-146
15847422-3	2005	When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1.	Nitrates	170-177	NBL1, DAN family BMP antagonist	Homo sapiens	8-11
22063496-4	2005	The effects of temperature, salt content, pH value and nitrate content on the activities of cathepsin B and L were evaluated using response surface methodology (RSM) and the actual activities of cathepsin B and L during Jinhua ham processing were calculated.	Nitrates	55-62	cathepsin B	Sus scrofa	92-103
15829709-5	2005	Total urinary nitrate and nitrite (NOx) excretion rates in UT-A1/3(-/-) mice were more than double those in wild-type mice.	Nitrates	14-21	solute carrier family 14 (urea transporter), member 2	Mus musculus	59-64
15908593-0	2005	Light-dark changes in cytosolic nitrate pools depend on nitrate reductase activity in Arabidopsis leaf cells.	Nitrates	32-39	nitrate reductase 1	Arabidopsis thaliana	56-73
15908593-8	2005	To study the role of assimilation, specifically the activity of NR in regulating the size of the cytosolic nitrate pool, we have compared wild-type and mutant plants.	Nitrates	107-114	nitrate reductase 1	Arabidopsis thaliana	64-66
15908593-10	2005	Such changes were not observed in nia1nia2 NR-deficient plants indicating that this change in cytosolic nitrate activity was dependent on the presence of functional NR.	Nitrates	104-111	nitrate reductase 1	Arabidopsis thaliana	165-167
15908593-12	2005	Epidermal cells of both wild type and NR mutants had cytosolic nitrate activities that were not significantly different from mesophyll cells in the dark and were unaltered by dark-to-light transitions.	Nitrates	63-70	nitrate reductase 1	Arabidopsis thaliana	38-40
15908593-13	2005	We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate.	Nitrates	54-61	nitrate reductase 1	Arabidopsis thaliana	20-22
15908593-13	2005	We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate.	Nitrates	127-134	nitrate reductase 1	Arabidopsis thaliana	20-22
15908593-13	2005	We propose that the NR-dependent changes in cytosolic nitrate provide a cellular mechanism for the diurnal changes in vacuolar nitrate storage, and the results are discussed in terms of the possible signaling role of cytosolic nitrate.	Nitrates	127-134	nitrate reductase 1	Arabidopsis thaliana	20-22
15914972-12	2005	Both CsA and L-NAME reduced urinary nitrate excretion, which was reversed by co-administration of L-Arg.	Nitrates	36-43	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	5-8
15847422-3	2005	When La(NO3)3 x 7H2O is used in place of LaCl3 x 6H2O, a similar structure is formed with the empirical formula, [La(pdc)(H2O)4] x NO3 (2), where water molecules and the nitrate anions occupy the voids as in the case of 1.	Nitrates	170-177	NBL1, DAN family BMP antagonist	Homo sapiens	131-134
15971422-2	2005	Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism.	Nitrates	222-229	xanthine dehydrogenase	Rattus norvegicus	143-166
15971422-2	2005	Nitrotyrosine is formed by nitration of tyrosine by reactive nitrogen species such as peroxynitrite, the formation of which may be enhanced by xanthine oxidoreductase (XOR), since it can generate nitric oxide from nitrite/nitrate, and superoxide during xanthine metabolism.	Nitrates	222-229	xanthine dehydrogenase	Rattus norvegicus	168-171
15718929-7	2005	Similarly, L-NMMA given prophylactically, but not therapeutically, blocked TNF-alpha-induced increases in exhaled NO flow rates and plasma nitrite and nitrate concentrations (both P = 0.02).	Nitrates	151-158	tumor necrosis factor	Canis lupus familiaris	75-84
15808411-7	2005	Nitrite formed either by autooxidation of NO or by conversion of nitrate to nitrite by xanthine oxidase was converted into the powerful nitric dioxide radical by lactoperoxidase and H(2)O(2) that is derived from the metabolism of xanthine oxidase.	Nitrates	65-72	lactoperoxidase	Bos taurus	162-177
16229082-7	2005	Data show, moreover, that the Arabidopsis dual affinity nitrate transporter NRT1.1 (CHL1) may be involved in conveying the nitrate signal into seeds.	Nitrates	56-63	nitrate transporter 1.1	Arabidopsis thaliana	76-82
16229082-7	2005	Data show, moreover, that the Arabidopsis dual affinity nitrate transporter NRT1.1 (CHL1) may be involved in conveying the nitrate signal into seeds.	Nitrates	56-63	nitrate transporter 1.1	Arabidopsis thaliana	84-88
15507538-10	2005	Both GHRP-2 (10(-7) M) and ghrelin (10(-7) M) prevented endotoxin-induced IL-6 and decreased nitrite/nitrate release from peritoneal macrophages in vitro.	Nitrates	101-108	ghrelin and obestatin prepropeptide	Rattus norvegicus	27-34
15838044-5	2005	Like aerobic conditions, anaerobic derepression of TCA cycle enzymes in an ArcA mutant significantly increased the in vivo TCA flux when nitrate was present as an electron acceptor.	Nitrates	137-144	arginine deiminase	Escherichia coli	75-79
15820896-4	2005	Each (py)2C(OEt)O- ion functions as an eta1:eta2:eta1:mu2 ligand in 1.0.5H2O chelating the two ZnII atoms through the 2-pyridyl nitrogen atoms and the common bridging, deprotonated oxygen atom; one asymmetric chelating nitrate completes six coordination at each metal center.	Nitrates	219-226	secreted phosphoprotein 1	Homo sapiens	39-43
15788155-3	2005	Murine IFN-gamma-activated peritoneal exudate cells (PEC) produced nitric oxide (NO), measured as nitrite plus nitrate, and superoxide.	Nitrates	111-118	interferon gamma	Mus musculus	7-16
15742413-8	2005	Plasma ET-1 level in DU patients was higher than that of H pylori-negative and positive controls (3.59+/-0.96 vs 0.89+/-0.54 vs 0.3+/-0.2 pg/mL, P&lt;0.01), while nitrate/nitrite levels among them were also significantly different (8.55+/-0.71 vs 5.27+/-0.68 vs 6.39+/-0.92 mumol/L, P&lt;0.05).	Nitrates	163-170	endothelin 1	Homo sapiens	7-11
16851295-5	2005	In contrast, with Y = NO3-, compounds such as CO or NO are formed during thermal treatment, indicating that nitrate ions burn the en ligands.	Nitrates	108-115	NBL1, DAN family BMP antagonist	Homo sapiens	22-25
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	251-254
15683794-4	2005	Compared with perchlorate solutions, the positive peak of nitrate solutions has a red shift of about 20 cm(-1) and the peak area is about half of that of perchlorate solutions with the same concentrations, indicating that the hydrogen bonding between NO3- and water monomers is relative stronger than that between ClO4- and water monomers, and NO3- has a strict requirement on the orientation of water molecules when hydrogen bonded with water monomers due to its planar structure.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	344-347
15707054-1	2005	Nitrate (NO3) is one of the world"s major pollutants of drinking water resources.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
15693824-4	2005	Nitrate reduction varied between individuals (mean 85.4 +/- 15.9 nmol nitrite min(-1) with 10 ml 1 mm KNO(3) mouth wash) and was found to be concentrated at the rear of the tongue dorsal surface.	Nitrates	0-7	CD59 molecule (CD59 blood group)	Homo sapiens	78-84
15707067-1	2005	This study investigated the reaction mechanisms of nitrate (NO3-) with zerovalent iron (ZVI) media under conditions relevantto groundwatertreatment using permeable reactive barriers (PRB).	Nitrates	51-58	NBL1, DAN family BMP antagonist	Homo sapiens	60-63
16101430-1	2005	Organic nitrates, such as nitroglycerin, have been used in clinical practice for more than one century for the treatment of angina, even before the identification of Nitric Oxide (NO) as the so-called Endothelium Derived Relaxing Factor (EDRF).	Nitrates	8-16	alpha hemoglobin stabilizing protein	Homo sapiens	238-242
16161783-5	2005	In addition, the reaction of hydrocarbons with NO3 potentially has important implications for NOy speciation because a significant fraction of organic nitrates thus formed are sufficiently long-lived to leave the planetary boundary layer.	Nitrates	151-159	NBL1, DAN family BMP antagonist	Homo sapiens	47-50
21676740-8	2005	We propose hypotheses suggesting that nitrate could alter steroidogenesis by 1) conversion to nitrite and nitric oxide in the mitochondria, the site of initial steroid synthesis, 2) altering Cl(-) ion concentrations in the cell by substituting for Cl(-) in the membrane transport pump or 3) binding to the heme region of various P450 enzymes associated with steroidogenesis and altering enzymatic action.	Nitrates	38-45	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	329-333
16459821-7	2005	Daily nitrate concentration as low as 1 mgN/L could be monitored in the effluent in some periods.	Nitrates	6-13	helt bHLH transcription factor	Homo sapiens	40-43
16187256-1	2005	Cell-free extracts of nitrate-grown Penicillium politans NRC-510 catalyzes the hydrolytic deamination of cytidine to uridine.	Nitrates	22-29	nuclear receptor coactivator 6	Homo sapiens	57-60
15690230-7	2005	Nitrate (NO3) concentrations dropped immediately after plant incorporation, and then rose monotonically until the end of the experiments.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
15623798-8	2005	Phosphorylated eNOS (pp-eNOS) protein levels in BRECs were significantly increased from low to high flow in both mono- and cocultures, concomitant with a significant increase in nitrate levels in the conditioned medium after exposure to pulsatile flow.	Nitrates	178-185	nitric oxide synthase 3	Bos taurus	15-19
15623798-8	2005	Phosphorylated eNOS (pp-eNOS) protein levels in BRECs were significantly increased from low to high flow in both mono- and cocultures, concomitant with a significant increase in nitrate levels in the conditioned medium after exposure to pulsatile flow.	Nitrates	178-185	nitric oxide synthase 3	Bos taurus	24-28
15577225-6	2004	Pretreatment with protocatechuic acid isopropyl ester effectively suppressed the LPS/GalN-induced increase in plasma tumor necrosis factor (TNF)-alpha alanine aminotransferase (ALT), nitrite/nitrate levels, and hepatic malondialdehyde levels.	Nitrates	191-198	toll-like receptor 4	Mus musculus	81-84
15498507-1	2004	It has been reported that macrophages produce substantial amounts of nitrite and nitrate after addition of catalase, but the mechanism associated remains unclear.	Nitrates	81-88	catalase	Mus musculus	107-115
15607619-6	2004	The level of plasma nitrite/nitrate was associated with the change in iNOS expression in SHR.	Nitrates	28-35	nitric oxide synthase 2	Rattus norvegicus	70-74
15554929-8	2004	In contrast, PARP-1(-/-) mice exhibited a significant reduction of colon damage and apoptosis, which was associated with increased colonic expression of Bcl-2 and lower levels of plasma nitrate/nitrite when compared to wild-type mice.	Nitrates	186-193	poly (ADP-ribose) polymerase family, member 1	Mus musculus	13-19
15475378-0	2004	Nitrate reductase regulation in tomato roots by exogenous nitrate: a possible role in tolerance to long-term root anoxia.	Nitrates	58-65	nitrate reductase [NADH]	Solanum lycopersicum	0-17
15452775-1	2004	The mechanism for the reaction between nitric oxide (NO) and O(2) bound to the heme iron of myoglobin (Mb), including the following isomerization to nitrate, has been investigated using hybrid density functional theory (B3LYP).	Nitrates	149-156	myoglobin	Homo sapiens	92-101
15567873-4	2004	METHODS: We used data from a multicentre, case-control study with maternal information on residential water source, and nitrate/nitrite levels of tap water measured by dipstick.	Nitrates	120-127	nuclear RNA export factor 1	Homo sapiens	146-149
15475378-1	2004	The mechanism of nitrate reductase (NR) regulation under long-term anoxia in roots of whole plants and the putative role of nitrate in anoxia tolerance have been addressed.	Nitrates	17-24	nitrate reductase [NADH]	Solanum lycopersicum	36-38
15475378-5	2004	NR was slightly dephosphorylated in the absence of oxygen and nitrate.	Nitrates	62-69	nitrate reductase [NADH]	Solanum lycopersicum	0-2
15475378-6	2004	Under anoxia, NR dephosphorylation was modulated by nitrate-controlled NR activity.	Nitrates	52-59	nitrate reductase [NADH]	Solanum lycopersicum	14-16
15475378-6	2004	Under anoxia, NR dephosphorylation was modulated by nitrate-controlled NR activity.	Nitrates	52-59	nitrate reductase [NADH]	Solanum lycopersicum	71-73
15205115-4	2004	We investigated the effect of LPS on nitrate/nitrite and cytokine production in relation to the expression of inducible nitric oxide synthase, NTCP, BSEP, and MRP2 both at the level of mRNA with RT-PCR and protein using immunofluorescence microscopy.	Nitrates	37-44	solute carrier family 10 member 1	Homo sapiens	143-147
15821986-0	2004	Ammonium transporter genes in Chlamydomonas: the nitrate-specific regulatory gene Nit2 is involved in Amt1;1 expression.	Nitrates	49-56	nitrilase family member 2	Homo sapiens	82-86
15821986-10	2004	This second effect of nitrate was dependent on the functionality of the regulatory gene Nit2, specific for nitrate assimilation.	Nitrates	22-29	nitrilase family member 2	Homo sapiens	88-92
15821986-10	2004	This second effect of nitrate was dependent on the functionality of the regulatory gene Nit2, specific for nitrate assimilation.	Nitrates	107-114	nitrilase family member 2	Homo sapiens	88-92
15821986-11	2004	Thus, NIT2 would have a dual role on gene expression: the well-known positive one on nitrate assimilation and a novel negative one on Amt1;1 regulation.	Nitrates	85-92	nitrilase family member 2	Homo sapiens	6-10
15465035-4	2004	We investigated the effect of the clinically used nitrates nitroglycerin (NTG), isosorbide dinitrate (ISDN), and sodium nitroprusside (SNP) on HIF-1-mediated transcriptional responses to hypoxia.	Nitrates	50-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-148
15465035-5	2004	We demonstrate that among the three nitrates, only SNP inhibits HIF-1 activation in response to hypoxia.	Nitrates	36-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-69
15331769-4	2004	Likewise, benomyl decreased GTN- and PETN-elicited phosphorylation of the cGMP-activated protein kinase substrate vasodilator-stimulated phosphoprotein (VASP) but not that elicited by other nitrates.	Nitrates	190-198	vasodilator-stimulated phosphoprotein	Rattus norvegicus	153-157
15331769-5	2004	The vasodilator potency of organic nitrates correlated with their potency to inhibit ALDH-2 dehydrogenase activity in mitochondria from rat heart and increase mitochondrial superoxide formation, as detected by chemiluminescence.	Nitrates	35-43	aldehyde dehydrogenase 2 family member	Rattus norvegicus	85-91
15331769-8	2004	We conclude that mitochondrial ALDH-2, specifically its esterase activity, is required for the bioactivation of the organic nitrates with high vasodilator potency, such as GTN and PETN, but not for the less potent nitrates.	Nitrates	124-132	aldehyde dehydrogenase 2 family member	Rattus norvegicus	31-37
15527785-4	2004	In cell homogenates, consumption of NO critically depended on the presence of NADPH or NADH and resulted in the formation of nitrate.	Nitrates	125-132	2,4-dienoyl-CoA reductase 1	Homo sapiens	78-83
15454240-2	2004	The inhibition of the newly discovered cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isozyme XIII of murine origin (mCA XIII) has been investigated with a series of anions, such as the physiological ones (bicarbonate, chloride), or the metal complexing anions (cyanate, cyanide, azide, hydrogen sulfide, etc), nitrate, nitrite, sulfate, sulfamate, sulfamide as well as with phenylboronic and phenylarsonic acids.	Nitrates	310-317	carbonic anhydrase 13	Mus musculus	116-124
15205115-4	2004	We investigated the effect of LPS on nitrate/nitrite and cytokine production in relation to the expression of inducible nitric oxide synthase, NTCP, BSEP, and MRP2 both at the level of mRNA with RT-PCR and protein using immunofluorescence microscopy.	Nitrates	37-44	ATP binding cassette subfamily C member 2	Homo sapiens	159-163
15210285-7	2004	Well water in the region of Fez has moderately poor water quality with nitrate and metal enrichments.	Nitrates	71-78	FEZ family zinc finger 1	Homo sapiens	28-31
15521966-7	2004	The serum concentrations of high density lipoprotein (HDL) cholesterol and nitrite/nitrate were significantly lower in the E4 group than in the E2 group (P &lt; 0.05).	Nitrates	83-90	ubiquitination factor E4A	Homo sapiens	123-125
15717134-0	2004	Prevention of nitrate tolerance with angiotensin II receptor type 1 blocker in patients with stable angina: yet another failed strategy to prevent tolerance.	Nitrates	14-21	angiotensin II receptor type 1	Homo sapiens	37-67
15570973-5	2004	The Co3O4 powders obtained by spraying nitrate solution at 500 degrees C show high specific surface area, which according to the BET method is 82.37 m2/g.	Nitrates	39-46	delta/notch like EGF repeat containing	Homo sapiens	129-132
15509836-0	2004	Mutation of a nitrate transporter, AtNRT1:4, results in a reduced petiole nitrate content and altered leaf development.	Nitrates	14-21	nitrate transporter 1.1	Arabidopsis thaliana	35-43
15310822-0	2004	Quantitative trait loci analysis of nitrate storage in Arabidopsis leading to an investigation of the contribution of the anion channel gene, AtCLC-c, to variation in nitrate levels.	Nitrates	167-174	chloride channel C	Arabidopsis thaliana	142-149
15310822-13	2004	In wild-type plants, expression of AtCLC-c was down-regulated in the presence of nitrate, but ammonium had a much smaller effect while chloride and sulphate did not affect expression.	Nitrates	81-88	chloride channel C	Arabidopsis thaliana	35-42
15310822-14	2004	These and published results suggest that multiple genes affect nitrate concentrations in plants and that AtCLC-c and other members of the AtCLC gene family play some role in this.	Nitrates	63-70	chloride channel C	Arabidopsis thaliana	105-112
15509836-7	2004	This study revealed a critical role of AtNRT1:4 in regulating leaf nitrate homeostasis, and the deficiency of AtNRT1:4 can alter leaf development.	Nitrates	67-74	nitrate transporter 1.1	Arabidopsis thaliana	39-47
15509836-2	2004	In the present study, characterization of the nitrate transporter, AtNRT1:4, revealed a special role of petiole in nitrate homeostasis.	Nitrates	46-53	nitrate transporter 1.1	Arabidopsis thaliana	67-75
15294282-8	2004	The nitrate KM for S-NaR1 was 30 +/- 3 microM, which is very similar to YNaR1.	Nitrates	4-11	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	21-25
15294282-2	2004	A simplified nitrate reductase (S-NaR1) consisting of Mo-MPT-binding site and nitrate-reducing active site was engineered from yeast Pichia angusta NaR cDNA (YNaR1).	Nitrates	13-20	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	34-38
15294282-9	2004	S-NaR1 is capable of specific nitrate reduction, and direct electric current, as shown by catalytic nitrate reduction using protein film cyclic voltammetry, can drive this reaction.	Nitrates	30-37	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	2-6
15294282-9	2004	S-NaR1 is capable of specific nitrate reduction, and direct electric current, as shown by catalytic nitrate reduction using protein film cyclic voltammetry, can drive this reaction.	Nitrates	100-107	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	2-6
15294282-10	2004	Thus, S-NaR1 is an ideal form of this enzyme for commercial applications, such as an enzymatic nitrate biosensor formulated with S-NaR1 interfaced to an electrode system.	Nitrates	95-102	iron-sulfur cluster assembly protein NAR1	Saccharomyces cerevisiae S288C	8-12
15333754-0	2004	Genomic analysis of the nitrate response using a nitrate reductase-null mutant of Arabidopsis.	Nitrates	24-31	nitrate reductase 1	Arabidopsis thaliana	49-66
15333754-6	2004	Because the nitrate response of these genes was NR independent, nitrate and not a downstream metabolite served as the signal.	Nitrates	12-19	nitrate reductase 1	Arabidopsis thaliana	48-50
15332144-9	2004	Residents with hypertension or diabetes mellitus, using nitrates or who were male were more likely to receive ACE inhibitors.	Nitrates	56-64	angiotensin I converting enzyme	Homo sapiens	110-113
15288585-0	2004	Aldehyde dehydrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta.	Nitrates	72-79	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-22
15288585-9	2004	The discrepancies are consistent with evidence that (a) organic nitrates, unlike chloral and cyanamide, irreversibly inactivate ALDH (hence reduced enzyme saturability can explain the biphasic curve) and (b) eNOS contributes to tolerance by a mechanism independent of glyceryl trinitrate metabolism.	Nitrates	64-72	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	128-132
15332144-10	2004	Appropriate ACE inhibitor doses were associated with functional impairment, nitrate use and recent hospitalization.	Nitrates	76-83	angiotensin I converting enzyme	Homo sapiens	12-15
15107992-0	2004	Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2 restricts growth at low external nitrate concentration.	Nitrates	18-25	nitrate transporter 2:1	Arabidopsis thaliana	44-52
15181112-5	2004	Very similar relationships were obtained for the steady-state levels of nii2 and nii4 mRNA in roots (2-4 x 10(5) and 8 x 10(6) copies microg(-1) of total RNA before and after nitrate treatment, respectively), and in leaves (5-9 x 10(4) and 4 x 10(5) copies microg(-1) of total RNA before and after nitrate treatment, respectively).	Nitrates	298-305	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	72-76
15107992-0	2004	Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2 restricts growth at low external nitrate concentration.	Nitrates	18-25	nitrate transporter 2:1	Arabidopsis thaliana	44-50
15276738-1	2004	A membrane bioreactor (MBR) was investigated for denitrification of nitrate (NO3(-)) contaminated drinking water.	Nitrates	68-75	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
15356331-0	2004	AtIPT3 is a key determinant of nitrate-dependent cytokinin biosynthesis in Arabidopsis.	Nitrates	31-38	isopentenyltransferase 3	Arabidopsis thaliana	0-6
15276755-7	2004	Nitrate concentration stabilized at about 6.3 mg NO3-N L(-1) for two weeks during alternating acetate pulse lengths.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
15166094-6	2004	Surprisingly, iNOS expression was not increased at 72 hours; instead, upregulation of neuronal NO synthase (nNOS) was evident at both the mRNA (+266+/-20%, P&lt;0.005) and the protein levels (+195+/-66%, P&lt;0.005), which was accompanied by an increase in myocardial nitrite/nitrate (+20+/-4%, P&lt;0.05).	Nitrates	276-283	nitric oxide synthase, brain	Oryctolagus cuniculus	108-112
15123642-0	2004	Nitrate reductase activity is required for nitrate uptake into fungal but not plant cells.	Nitrates	43-50	nitrate reductase 1	Arabidopsis thaliana	0-17
15123642-1	2004	The ability to transport net nitrate was conferred upon transformant cells of the non-nitrate-assimilating yeast Pichia pastoris after the introduction of two genes, one encoding nitrate reductase and the other nitrate transport.	Nitrates	29-36	nitrate reductase 1	Arabidopsis thaliana	179-196
15123642-3	2004	In addition, loss-of-function nitrate reductase mutants isolated from several nitrate-assimilating fungi appeared to be unable to accumulate nitrate.	Nitrates	78-85	nitrate reductase 1	Arabidopsis thaliana	30-47
15179450-10	2004	The finding of increased liver nitrite/nitrate content in NCX-1000-treated animals together with an increase in cGMP levels in their liver homogenates suggests that this nitro-compound behaves as a liver-selective NO donor.	Nitrates	39-46	T cell leukemia homeobox 2	Homo sapiens	58-61
15123642-4	2004	Uptake assays using the tracer (13)NO(3)(-) showed that nitrate influx is negligible in cells of a nitrate reductase null mutant.	Nitrates	56-63	nitrate reductase 1	Arabidopsis thaliana	99-116
15123642-5	2004	In parallel studies using a higher eukaryotic plant, Arabidopsis thaliana, loss-of-function nitrate reductase strains homozygous for both NIA1 insertion and NIA2 deletion were found to have no detectable nitrate reductase mRNA or nitrate reductase activity but retained the ability to transport nitrate.	Nitrates	92-99	nitrate reductase 1	Arabidopsis thaliana	138-142
15123642-5	2004	In parallel studies using a higher eukaryotic plant, Arabidopsis thaliana, loss-of-function nitrate reductase strains homozygous for both NIA1 insertion and NIA2 deletion were found to have no detectable nitrate reductase mRNA or nitrate reductase activity but retained the ability to transport nitrate.	Nitrates	92-99	nitrate reductase 2	Arabidopsis thaliana	157-161
15223851-3	2004	Both of these Pde-5 inhibitors have vasodilating properties and effects on blood pressure (BP), and like nitrates, they work through the nitric oxide cyclic guanosine monophosphate pathway.	Nitrates	105-113	phosphodiesterase 5A	Homo sapiens	14-19
15197447-8	2004	Without any exception it applies to all three PDE 5 inhibitors that they are absolutely contraindicated in patients taking nitrate- or molsidomine-containing medications and that they may interact in particular with non-uroselective alpha-adrenoceptor blockers.	Nitrates	123-130	phosphodiesterase 5A	Homo sapiens	46-51
15214777-4	2004	Chemiluminescence detection experiments show the ability of catalase to catalyze the formation of nitrite and nitrate from hydroxyurea.	Nitrates	110-117	catalase	Homo sapiens	60-68
15461259-5	2004	When the initial nitrate concentration was 30.7mg NO3- -N/L, the denitrification rate was 38.4% at an applied electric current of 10mA and a hydraulic retention time of 12 hours.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
15212692-0	2004	The outer membrane protein Omp35 affects the reduction of Fe(III), nitrate, and fumarate by Shewanella oneidensis MR-1.	Nitrates	67-74	porin	Shewanella oneidensis MR-1	27-32
15370692-7	2004	Intravenous infusion of human adrenomedullin induced a reduction of mean arterial pressure together with an increase of serum nitrate levels, which was abolished by neutralizing antibody against adrenomedullin.	Nitrates	126-133	adrenomedullin	Homo sapiens	30-44
15370692-7	2004	Intravenous infusion of human adrenomedullin induced a reduction of mean arterial pressure together with an increase of serum nitrate levels, which was abolished by neutralizing antibody against adrenomedullin.	Nitrates	126-133	adrenomedullin	Homo sapiens	195-209
15212692-6	2004	Although OMP35-1 grew on all electron acceptors tested, a significant lag was seen when grown on fumarate, nitrate, and Fe(III).	Nitrates	107-114	porin	Shewanella oneidensis MR-1	9-14
15212692-14	2004	Omp35 is required for normal rates of growth on Fe(III), fumarate, and nitrate, but its absence has no effect on the use of other electron acceptors.	Nitrates	71-78	porin	Shewanella oneidensis MR-1	0-5
15196936-1	2004	Dihydrolipoamide dehydrogenase (DLDH; EC 1.8.1.4) from porcine heart is capable of using nitric oxide (NO) as an electron acceptor, with NADH as the electron donor, forming nitrate in the reaction.	Nitrates	173-180	dihydrolipoamide dehydrogenase	Homo sapiens	0-30
15224139-11	2004	The results suggested that eNOS gene promoter activity was enhanced to 148.2+/-33.7% (P&lt;0.05) of the control after PAECs were incubated with 10 micromol/L histamine for 24 h. The nitrite and nitrate content in culture media measured by colorimetric method after incubation with 10 micromol/L histamine for 24 h indicated that the NO production in PAECs was increased.	Nitrates	194-201	nitric oxide synthase 3	Homo sapiens	27-31
15196936-1	2004	Dihydrolipoamide dehydrogenase (DLDH; EC 1.8.1.4) from porcine heart is capable of using nitric oxide (NO) as an electron acceptor, with NADH as the electron donor, forming nitrate in the reaction.	Nitrates	173-180	dihydrolipoamide dehydrogenase	Homo sapiens	32-36
15107452-7	2004	The complex regulation of nitrate reduction is likely to have evolved not only to optimize nitrogen assimilation, but also to prevent and control the formation of toxic, and possibly regulatory, products of NR activities.	Nitrates	26-33	nitrate reductase 1	Arabidopsis thaliana	207-209
14963706-1	2004	Nitrate reductase (NR, EC 1.6.6.1) is a key regulatory enzyme in the assimilation of nitrate into amino acids in plant leaves.	Nitrates	85-92	nitrate reductase [NADH]	Solanum lycopersicum	0-17
15191513-7	2004	In these patients (inducible nitric oxide synthase-positive group), the serum level of gastrin was significantly higher than that of the inducible nitric oxide synthase-negative group (509.5 +/- 141.5 pg/mL vs. 210.0 +/- 227.2 pg/mL; P &lt; 0.01), whereas there were no significant differences in serum levels of pepsinogen, anti-parietal cell antibody, and nitrate and nitrite or in scores of histological gastritis.	Nitrates	358-365	gastrin	Homo sapiens	87-94
15094329-9	2004	administration show a more pronounced and rapid NO delivery (peak of both NOx and RS-NO at 1 h and plateau between 1 and 2 h), still coincident with the peak of SA, and the presence in plasma of NCX 4015 (a metabolite of NCX 4016 which still bears the nitrate function).	Nitrates	252-259	solute carrier family 8 member A1	Rattus norvegicus	195-198
15094329-9	2004	administration show a more pronounced and rapid NO delivery (peak of both NOx and RS-NO at 1 h and plateau between 1 and 2 h), still coincident with the peak of SA, and the presence in plasma of NCX 4015 (a metabolite of NCX 4016 which still bears the nitrate function).	Nitrates	252-259	solute carrier family 8 member A1	Rattus norvegicus	221-224
14963706-1	2004	Nitrate reductase (NR, EC 1.6.6.1) is a key regulatory enzyme in the assimilation of nitrate into amino acids in plant leaves.	Nitrates	85-92	nitrate reductase [NADH]	Solanum lycopersicum	19-21
15155540-2	2004	In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point.	Nitrates	169-176	myeloperoxidase	Mus musculus	20-35
15080860-2	2004	Our previous studies suggested a relationship between cerebrospinal fluid (CSF) NO metabolites (nitrates and nitrites, NN(x)) and IGF-1 in patients with progressive encephalopathy, hypsarrhythmia and optic atrophy syndrome.	Nitrates	96-104	insulin like growth factor 1	Homo sapiens	130-135
15088102-9	2004	Nitrite and nitrate release from hearts before (2.3 +/- 0.9 nmol/min/g) and after (2.4 +/- 1.9 nmol/min/g) 15 min treatment with erythropoietin (1.0 U/ml) were not different.	Nitrates	12-19	erythropoietin	Oryctolagus cuniculus	129-143
15155540-2	2004	In 8-week-old mice, myeloperoxidase (MPO) levels are significantly elevated in the early phase at 6 h and reach their maximum at 24 h to decline to basal value at 48 h. Nitrate+nitrite (NO(x)) levels in the paw are maximal after 2 h and slowly decline thereafter in contrast to prostaglandin E(2) levels that peak in the second phase at the 72 h point.	Nitrates	169-176	myeloperoxidase	Mus musculus	37-40
15224936-1	2004	In the context of agricultural nitrogen excesses in northwestern France, pyrite-bearing weathered schist aquifers represent important hydrological compartments due to their capacity to eliminate nitrate (NO3-).	Nitrates	195-202	NBL1, DAN family BMP antagonist	Homo sapiens	204-207
15135199-9	2004	Nitrate/nitrite level, glutamic oxalacetic transaminase (GOT) level and creatinine level were also significantly improved in AG+ANGII-treated rats compared to the other groups.	Nitrates	0-7	angiotensinogen	Rattus norvegicus	128-133
15050440-1	2004	The findings of various studies reporting temporal changes in CSF total nitrite/nitrate (NOx) levels after subarachnoid hemorrhage (SAH) vary considerably.	Nitrates	80-87	colony stimulating factor 2	Homo sapiens	62-65
15115189-8	2004	The one major precaution for men taking PDE5 inhibitors is to avoid concomitant administration of therapeutic and recreational nitrate preparations.	Nitrates	127-134	phosphodiesterase 5A	Homo sapiens	40-44
15116844-1	2004	Increased nitrate (NO3) concentrations in streamwaters draining forested catchments are reportedly an early indicator of nitrogen (N) saturation.	Nitrates	10-17	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
14665447-12	2004	Expressions of endothelial NOS protein and NOx, the stable end product of NO, i.e., nitrite/nitrate, concentration in the kidney were significantly lower in the vehicle-treated exercise group than in the vehicle-treated sedentary group, whereas those in the TA-0201-treated exercise group were significantly higher than those in the vehicle-treated exercise group.	Nitrates	92-99	nitric oxide synthase 3	Rattus norvegicus	15-30
15112822-1	2004	The isotopic composition of nitrate collected from aerosols, fog, and precipitation was measured and found to have a large 17O anomaly with delta17O values ranging from 20 percent per thousand to 30% percent per thousand (delta17O = delta17O - 0.52(delta18O)).	Nitrates	28-35	zinc finger protein, FOG family member 1	Homo sapiens	61-64
15074615-12	2004	Taking into account the proximity of the sampling site to the sea, and the observed chloride depletion, coarse mode nitrate, during the non-Asian dust period, is assumed to originate from the reaction of nitric acid with sodium chloride on the surfaces of sea-salt particles although the chloride depletion was not shown to be large enough to prove this assumption.	Nitrates	116-123	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	256-259
15041240-5	2004	The monomeric 8-coordinate complex [Bi(mtsc)2(NO3)], 4b, which was obtained by slow evaporation in MeOH of the 1.5 hydrates 4a, was depicted with one electron pair of the bismuth(III) atom, two deprotonated mtsc- ligand and one nitrate ion.	Nitrates	228-235	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
15084732-3	2004	In plants, GATA DNA motifs have been implicated in light-dependent and nitrate-dependent control of transcription.	Nitrates	71-78	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	11-15
15076233-0	2004	Development of insulin resistance by nitrate tolerance in conscious rabbits.	Nitrates	37-44	insulin	Oryctolagus cuniculus	15-22
16649597-4	2004	It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%.	Nitrates	101-108	protein interacting with PRKCA 1	Homo sapiens	109-113
16649597-4	2004	It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%.	Nitrates	101-108	protein interacting with PRKCA 1	Homo sapiens	109-113
16649597-4	2004	It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%.	Nitrates	101-108	protein interacting with PRKCA 1	Homo sapiens	109-113
16649597-4	2004	It has been found out in the present study that in the domestic sewage, the chloride pick-up is 71%, nitrate pick-up is 97%, total hardness pick-up is 20 %, iron pick-up is 98% and zinc pick-up is 98%.	Nitrates	101-108	protein interacting with PRKCA 1	Homo sapiens	109-113
14871307-11	2004	Nevertheless, our findings indicate the possibility that 14-3-3 binding to SnRK1-phosphorylated sites on NR and F2KP may regulate both nitrate assimilation and sucrose/starch partitioning in leaves.	Nitrates	135-142	nitrate reductase 1	Arabidopsis thaliana	105-107
14871307-11	2004	Nevertheless, our findings indicate the possibility that 14-3-3 binding to SnRK1-phosphorylated sites on NR and F2KP may regulate both nitrate assimilation and sucrose/starch partitioning in leaves.	Nitrates	135-142	fructose-2,6-bisphosphatase	Arabidopsis thaliana	112-116
15076233-8	2004	We conclude that acutely nitrate patches improve insulin sensitivity whereas a 7-day chronic treatment schedule that results in hemodynamic nitrate tolerance also produces insulin resistance.	Nitrates	25-32	insulin	Oryctolagus cuniculus	49-56
14707155-7	2004	Acetylcholine (ACh)-induced relaxation of Phe contraction and vascular eNOS protein and nitrite/nitrate production were less in IL-6-infused than in control pregnant rats.	Nitrates	96-103	interleukin 6	Rattus norvegicus	128-132
15228008-8	2004	Nitrate and light intensity positively regulate the gene transcription of NR, but ammonium ions and Glu, Gln do the negative way.	Nitrates	0-7	inducible nitrate reductase [NADH] 1	Glycine max	74-76
14755345-9	2004	These observations suggest that nitrate tolerance is mediated, at least in significant part, by inhibition of vascular ALDH-2 and that mitochondrial ROS contribute to this inhibition.	Nitrates	32-39	aldehyde dehydrogenase 2 family member	Rattus norvegicus	119-125
14968431-0	2004	The role of Ynt1 in nitrate and nitrite transport in the yeast Hansenula polymorpha.	Nitrates	20-27	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	12-16
14968347-19	2004	Thus, the ability to activate HO-1 induction and associated antioxidant pathways apparently distinguishes PETN from other long-acting nitrates and may explain their different patterns of action in vivo (Figure 9).	Nitrates	134-142	heme oxygenase 1	Homo sapiens	30-34
15356719-6	2004	The crystal structure of Yb(L(4))(NO(3))(3) shows ytterbium in a 9-coordinate environment being bonded to three donor atoms of the ligand and three bidentate nitrate ions.	Nitrates	158-165	ribosomal protein L4	Homo sapiens	28-32
14709911-3	2004	However, we recently identified PAP-I as a metabolic enzyme of an organic nitrate compound, RS-7897, which contains L-2-oxothiazolidine-4-carboxylic acid (L-OTCA).	Nitrates	74-81	pyroglutamyl-peptidase I	Rattus norvegicus	32-37
14968431-1	2004	Ynt1 is the only high-affinity nitrate uptake system in Hansenula polymorpha.	Nitrates	31-38	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	0-4
14968431-2	2004	Nitrate uptake was directly correlated with the Ynt1 levels and shown to be independent of nitrate reductase (NR) activity levels.	Nitrates	0-7	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	48-52
14968431-4	2004	Nitrite uptake in a wild-type strain was partially inhibited by nitrate to levels shown by a YNT1-disrupted strain in which, in turn, nitrite transport was not inhibited by nitrate.	Nitrates	64-71	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	93-97
14968431-8	2004	At pH 5.5, the contribution of Ynt1 to high-affinity nitrate and nitrite uptake was around 95% and 60%, respectively.	Nitrates	53-60	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	31-35
14968431-9	2004	The apparent Km of Ynt1 for nitrate and nitrite is in the microM range, as is the specific nitrite uptake system for nitrite.	Nitrates	28-35	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	19-23
14968431-10	2004	The analysis of the effect of the reduced nitrogen sources on nitrate assimilation revealed that glutamine inactivates nitrate and nitrite transport, dependent on Ynt1, but not the nitrite-specific system.	Nitrates	119-126	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	163-167
15537369-22	2004	The use of PDE5 inhibitors in the presence of oral nitrates is absolutely contraindicated.	Nitrates	51-59	phosphodiesterase 5A	Homo sapiens	11-15
15108630-1	2004	Nitrite (NO2-) and nitrate (NO3-) concentrations are usually measured as a marker of NO metabolism.	Nitrates	19-26	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
15022606-1	2004	Nitrite (NO2) and nitrate (NO3) concentrations are usually measured as a marker of NO metabolism.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
15244341-4	2004	The OCN pellet slowly releases calcium and nitrate, together with ocher, into the sediment water interface, where all three components play an important role in reducing phosphate release from sediments.	Nitrates	43-50	bone gamma-carboxyglutamate protein	Homo sapiens	4-7
15199233-1	2004	Nitrite and nitrate are widely used reporters of endogenous nitric oxide (NO) and nitric oxide synthase (NOS) activity, which are crucial for a broad spectrum of physiological and pathophysiological pathways.	Nitrates	12-19	nitric oxide synthase 2	Homo sapiens	82-103
15199238-1	2004	Measurement of the nitric oxide (NO) metabolites nitrite and nitrate in biological matrices is a reliable method to assess NO synthase (NOS) activity.	Nitrates	61-68	nitric oxide synthase 2	Homo sapiens	123-134
14675438-7	2004	AtIPT3 was upregulated within 1 h after an application of nitrate to mineral-starved Arabidopsis plants.	Nitrates	58-65	isopentenyltransferase 3	Arabidopsis thaliana	0-6
15588129-2	2004	In the presence of NADH or NADPH, diaphorase can convert selected NO donors, glycerol trinitrate (GTN) and formaldoxime (FAL) to nitrites and nitrates with NO as an intermediate.	Nitrates	142-150	dihydrolipoamide dehydrogenase	Homo sapiens	34-44
15032873-12	2004	Furthermore, the induction of glucose 6-phosphate dehydrogenase isoforms by ammonium and of ferredoxin and ferredoxin-NADP reductase by nitrate has been described.	Nitrates	136-143	glucose-6-phosphate dehydrogenase	Homo sapiens	30-63
15032873-12	2004	Furthermore, the induction of glucose 6-phosphate dehydrogenase isoforms by ammonium and of ferredoxin and ferredoxin-NADP reductase by nitrate has been described.	Nitrates	136-143	ferredoxin reductase	Homo sapiens	107-132
15230126-1	2004	AIM: To elucidate clinical implications of nitrates (NO3) concentration as an indicator of nitric oxide (NO) level in blood serum of patients with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (PAPS).	Nitrates	43-51	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
14643177-6	2004	Also, this dose of EGF diminished nitrate production significantly (P&lt;0.01).	Nitrates	34-41	epidermal growth factor like 1	Rattus norvegicus	19-22
15137421-3	2004	Generation of nitrogen gas (N2) and ammonium nitrogen (NH4-N) was simultaneously observed in the low load of nitrate (NO3-N) (below 0.68 g NO3-N/L).	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	118-121
14630420-1	2003	The average nitrate concentration in the groundwater of the Vitoria-Gasteiz (Basque Country) quaternary aquifer rose from 50 mg NO3-/l during 1986 to over 200 mg/l in 1995, which represents an increase of some 20 mg NO3-/l per year.	Nitrates	12-19	NBL1, DAN family BMP antagonist	Homo sapiens	128-131
14630420-1	2003	The average nitrate concentration in the groundwater of the Vitoria-Gasteiz (Basque Country) quaternary aquifer rose from 50 mg NO3-/l during 1986 to over 200 mg/l in 1995, which represents an increase of some 20 mg NO3-/l per year.	Nitrates	12-19	NBL1, DAN family BMP antagonist	Homo sapiens	216-219
14630420-11	2003	The mass of nitrate leached from the cultivated zone is five times higher than that of the nitrate leached from the uncultivated zone (1147 kg NO3-/ha in the cultivated sector as against 211 kg NO3-/ha in the uncultivated sector), although part of the nitrate leached into the soil had been previously deposited by the rise of the water table.	Nitrates	12-19	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
14630420-11	2003	The mass of nitrate leached from the cultivated zone is five times higher than that of the nitrate leached from the uncultivated zone (1147 kg NO3-/ha in the cultivated sector as against 211 kg NO3-/ha in the uncultivated sector), although part of the nitrate leached into the soil had been previously deposited by the rise of the water table.	Nitrates	12-19	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
14630420-12	2003	If we consider that the level of groundwater input is similar in both plots, we may conclude that 964 kg NO3-/ha circulated towards the groundwater in the cultivated zone during the period under study, representing 87% of the nitrate applied to the soil in the form of fertilizer during that period.	Nitrates	226-233	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
15137421-3	2004	Generation of nitrogen gas (N2) and ammonium nitrogen (NH4-N) was simultaneously observed in the low load of nitrate (NO3-N) (below 0.68 g NO3-N/L).	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	139-142
14664604-1	2003	We have examined the photochemical reactions occurring after irradiation at 200 nm of the aqueous nitrate ion, NO3(-)(aq).	Nitrates	98-105	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
12907425-7	2003	BBS-2 treatment blocked NOS2 dimerization and completely inhibited the endotoxin-induced increase of plasma nitrate and nitrite levels.	Nitrates	108-115	Bardet-Biedl syndrome 2 (human)	Mus musculus	0-5
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Nitrates	215-222	nitric oxide synthase 2	Homo sapiens	28-32
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Nitrates	215-222	myeloperoxidase	Homo sapiens	47-50
14657339-8	2003	Scavenging free NO from the iNOS milieu by the MPO/H2O2 system subsequently restores the full capacity of iNOS to convert L-arginine to product (NO), as judged by the increase in the rates of citrulline and nitrite/nitrate production.	Nitrates	215-222	nitric oxide synthase 2	Homo sapiens	106-110
14636072-0	2003	Metmyoglobin and methemoglobin catalyze the isomerization of peroxynitrite to nitrate.	Nitrates	78-85	hemoglobin subunit gamma 2	Homo sapiens	17-30
14622500-4	2003	PDE-5 inhibitors have been shown to be safe and effective for the therapy for ED, but remain contraindicated in patients receiving organic nitrates.	Nitrates	139-147	phosphodiesterase 5A	Homo sapiens	0-5
12958042-8	2003	Nitrate levels markedly increased with ecSOD in injured artery homogenates (26+/-5 versus 4+/-0.3 micromol/L per mg, P=0.001).	Nitrates	0-7	extracellular superoxide dismutase [Cu-Zn]	Oryctolagus cuniculus	39-44
14606859-2	2003	The nitrate complexes (X = NO(3); M = Mn (1), Co (2), Ni (3), Cu (4)) crystallize isomorphously in monoclinic space group P2(1)/a.	Nitrates	4-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	122-127
14642608-8	2003	Administration of NCX-1000 to BDL and sham operated rats resulted in a similar increase of nitrite/nitrate and cGMP concentrations in the liver.	Nitrates	99-106	solute carrier family 8 member A1	Rattus norvegicus	18-21
14642695-0	2003	Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance.	Nitrates	69-76	prostaglandin I2 synthase	Rattus norvegicus	44-65
14642699-1	2003	OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear.	Nitrates	68-75	phosphodiesterase 5A	Homo sapiens	106-125
14642699-1	2003	OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear.	Nitrates	68-75	phosphodiesterase 5A	Homo sapiens	127-131
14642699-1	2003	OBJECTIVES: This study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t(1/2)) of 17.5 h. BACKGROUND: The PDE5 inhibitors augment the blood pressure (BP)-lowering effects of nitrates, yet the time course of this interaction is unclear.	Nitrates	68-75	phosphodiesterase 5A	Homo sapiens	196-200
14616932-0	2003	Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA).	Nitrates	62-70	angiotensin I converting enzyme	Homo sapiens	20-23
14568906-3	2003	In addition, tissue concentrations of nitrite and nitrate were significantly increased in rats transfected with the eNOS gene up to 2 weeks after transfection.	Nitrates	50-57	nitric oxide synthase 3	Rattus norvegicus	116-120
14616932-2	2003	The aim of this study was to explore whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates.	Nitrates	150-158	angiotensin I converting enzyme	Homo sapiens	93-96
14616932-7	2003	Headache caused by nitrates was recorded in 12/762 (1.6%) ACE inhibitor users and in 24/775 (3.2%) other participants (P = 0.049).	Nitrates	19-27	angiotensin I converting enzyme	Homo sapiens	58-61
14616932-10	2003	In conclusion, this study suggests that among hypertensive subjects use of ACE inhibitors is associated with a reduced risk of headache caused by nitrates.	Nitrates	146-154	angiotensin I converting enzyme	Homo sapiens	75-78
14555283-7	2003	Nicorandil is able to inhibit TNFalpha release from lymphocytes, which requires the dual modes of both potassium channel opening and the nitrate moiety.	Nitrates	137-144	tumor necrosis factor	Homo sapiens	30-38
14573760-0	2003	Role of mitochondrial aldehyde dehydrogenase in nitrate tolerance.	Nitrates	48-55	aldehyde dehydrogenase 2 family member	Rattus norvegicus	8-44
16736996-0	2003	[Anti-ischemic effect of angiotensin-converting enzyme inhibitor, but not vitamin C, in patients with coronary artery disease treated with beta-blockers and nitrates.	Nitrates	157-165	angiotensin I converting enzyme	Homo sapiens	25-54
16736996-2	2003	Anti-ischemic effect of angiotensin-converting enzyme inhibitor--chinapril was examined by exercise tolerance test [ETT] in randomised, cross-over double blind comparison in 20 pts with coronary artery disease treated with beta-blockers and nitrates.	Nitrates	241-249	angiotensin I converting enzyme	Homo sapiens	24-53
14512447-1	2003	Nitrate tolerance (NT) in hypertension is attributed to reduced activity of soluble guanylyl cyclase (sGC).	Nitrates	0-7	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	76-100
15011737-2	2003	An indirect form to detect NO production has been the quantification of its stable end products, nitrites and nitrates (NO2- + NO3-).	Nitrates	110-118	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
14520629-3	2003	Recently, a gene polymorphism of the endothelial NO synthase (ENOS) gene was identified that is associated with circulating nitrate levels.	Nitrates	124-131	nitric oxide synthase 3	Homo sapiens	62-66
13679077-6	2003	We demonstrate that peroxynitrite and myeloperoxidase nitrate xanthine in vitro.	Nitrates	54-61	myeloperoxidase	Homo sapiens	38-53
14512447-1	2003	Nitrate tolerance (NT) in hypertension is attributed to reduced activity of soluble guanylyl cyclase (sGC).	Nitrates	0-7	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	102-105
12892664-5	2003	Moreover, the high sulfate and nitrate conversion values (SOR and NOR) presented herein suggest that secondary formations from SO2 to SO4(2-) and from NO2 to NO3- are present in significant quantities in the atmosphere of southern Taiwan on episode days.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	158-161
14692506-4	2003	Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison.	Nitrates	141-148	carbonic anhydrase 1	Homo sapiens	42-46
12974902-4	2003	The current study was undertaken to evaluate the relationship between plasma EPO levels and the severity of liver disease, hemodynamic values, renal functions, and plasma nitrate/nitrite levels in patients with cirrhosis.	Nitrates	171-178	erythropoietin	Homo sapiens	77-80
14692506-4	2003	Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison.	Nitrates	141-148	carbonic anhydrase 2	Homo sapiens	51-56
14581628-4	2003	Transcripts of Ntdin are induced by sulfate or nitrate but not by phosphate, suggesting its involvement in sulfur and nitrogen metabolism.	Nitrates	47-54	thiosulfate sulfurtransferase 16, chloroplastic-like	Nicotiana tabacum	15-20
14499528-5	2003	Over a period exceeding 100 years mean nitrate concentrations increased from 1.04 mg NO3-Nl(-1) to 6.37 mg NO3-Nl(-1).	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
14499528-5	2003	Over a period exceeding 100 years mean nitrate concentrations increased from 1.04 mg NO3-Nl(-1) to 6.37 mg NO3-Nl(-1).	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	107-110
14499528-7	2003	Nitrate data throughout this early period reflect natural background concentrations of approximately 1 mg NO3-Nl(-1).	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	106-109
14512099-3	2003	In SHR, the NCX 4016 treatment increased the serum nitrite/nitrate and diminished the serum thromboxane B2, whereas aspirin did not change blood pressure but abolished the serum thromboxane B2.	Nitrates	59-66	solute carrier family 8 member A1	Rattus norvegicus	12-15
12952843-0	2003	Attenuation of nitrate tolerance and oxidative stress by an angiotensin II receptor blocker in patients with coronary spastic angina.	Nitrates	15-22	angiotensinogen	Homo sapiens	60-74
12952843-11	2003	These results suggest that increased oxidative stress induced by activation of angiotensin II may play an important role in the development of nitrate tolerance.	Nitrates	143-150	angiotensinogen	Homo sapiens	79-93
14611844-3	2003	Inhibition data of the cytosolic isozymes CA I and CA II as well as the membrane-bound isozyme CA IV with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, sulfamate, and sulfamidate and so on, are also provided for comparison.	Nitrates	185-192	carbonic anhydrase 4	Homo sapiens	95-100
12927686-0	2003	Comparison of cadmium and enzyme-catalyzed nitrate reduction for determination of NO2-/NO3- in breath condensate.	Nitrates	43-50	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
12950342-1	2003	Nitric oxide (NO) is a free radical synthesized from l-arginine by a family of NO synthase (NOS) enzymes, all of which are present in the skin, and also by reduction of sweat nitrate.	Nitrates	175-182	nitric oxide synthase 1, neuronal	Mus musculus	79-90
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Nitrates	72-79	transcription factor MYB101	Glycine max	112-118
14692450-9	2003	stressed two Michaelis-Menten (MM) mechanisms to mediate the observed nitrate-induced currents, I(NO3-).	Nitrates	70-77	NBL1, DAN family BMP antagonist S homeolog	Xenopus laevis	98-101
15969098-0	2003	[Induced activity of nitrate reductase by nitrate and cloning of nitrate reductase gene].	Nitrates	21-28	nitrate reductase [NADH]	Solanum lycopersicum	65-82
15969098-3	2003	Enhancing the activity of NR is conducive to reduce the concentration of nitrate in plants.	Nitrates	73-80	nitrate reductase [NADH]	Solanum lycopersicum	26-28
15969098-16	2003	According to these results, the level of NR mRNA in plants could be enhanced by nitrate inducement.	Nitrates	80-87	nitrate reductase [NADH]	Solanum lycopersicum	41-43
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Nitrates	72-79	transcription factor MYB101	Glycine max	214-220
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Nitrates	276-283	transcription factor MYB101	Glycine max	112-118
14756320-9	2003	The expression analysis of the genes showed that the organ-specific and nitrate-regulated expression profile of MYB101 was very similar to that of CHS in Lotus as well as in soybean, suggesting a possible role for MYB101 in regulation of flavonoid biosynthesis in response to nitrate starvation.	Nitrates	276-283	chalcone synthase 3	Glycine max	147-150
12869520-0	2003	Induction of nitrate uptake in maize roots: expression of a putative high-affinity nitrate transporter and plasma membrane H+-ATPase isoforms.	Nitrates	13-20	membrane H(+)-ATPase 1	Zea mays	107-132
12899636-1	2003	The tetraheme c-type cytochrome, CymA, from Shewanella oneidensis MR-1 has previously been shown to be required for respiration with Fe(III), nitrate, and fumarate [Myers, C. R., and Myers, J. M. (1997) J. Bacteriol.	Nitrates	142-149	cytochrome c	Shewanella oneidensis MR-1	33-37
12869520-7	2003	Both genes, classified as members of the PM H+-ATPase subfamily II, responded to nitrate supply, although to different degrees: MHA4, in particular, proved more sensitive than MHA3, with a greater up- and down-regulation in response to the treatment.	Nitrates	81-88	proton-exporting ATPase 4	Zea mays	128-132
12871833-12	2003	However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue.	Nitrates	23-30	nitric oxide synthase 2	Rattus norvegicus	153-184
12834739-7	2003	This observation suggested that in addition to the two well-accepted groups of phosphorus removal bacteria (one can only utilize oxygen to take up phosphorus, P(O), while the other can use both oxygen and nitrate, P(ON)), a new group of phosphorus removal bacteria, P(ON(n)), which could use oxygen, nitrate or nitrite to take up phosphorus was identified.	Nitrates	300-307	paraoxonase 1	Homo sapiens	214-219
12754263-11	2003	These results demonstrate that (i) exogenously supplied glucose can replace the function of photoassimilates in roots; (ii) APR is subject to co-ordinated metabolic control by carbon metabolism; (iii) positive sugar signalling overrides negative signalling from nitrate assimilation in APR regulation.	Nitrates	262-269	APS reductase 1	Arabidopsis thaliana	124-127
12871833-12	2003	However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue.	Nitrates	23-30	nitric oxide synthase 2	Rattus norvegicus	186-190
12871833-12	2003	However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue.	Nitrates	23-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	196-212
12871833-12	2003	However, inhibition of nitrate generation was observed only during the late phase (at 4 h after carrageenan injection), accompanied by an attenuation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in paw tissue.	Nitrates	23-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	214-219
12690103-1	2003	A significant increase in the induction of inducible nitric-oxide synthase (iNOS) protein expression and in the levels of nitrite plus nitrate was observed in rat aortic smooth muscle cells (RASMCs) stably transfected with catalase (RASMC-2C2) as compared with empty vector-transfected RASMC-V4 cells after exposure to cytokines and lipopolysaccharide.	Nitrates	135-142	catalase	Rattus norvegicus	223-231
12804571-8	2003	The effects of formate on ATPase activity disappeared when cells were performing anaerobic (nitrate/nitrite) or aerobic respiration.	Nitrates	92-99	ATPase	Escherichia coli	26-32
12805587-1	2003	The genomic response to low levels of nitrate was studied in Arabidopsis using the Affymetrix ATH1 chip containing more than 22,500 probe sets.	Nitrates	38-45	homeobox protein ATH1	Arabidopsis thaliana	94-98
12892378-6	2003	Concomitantly, plasma NO products (nitrate + nitrite), which increased 2.2-fold during Mg-deficiency, were completely suppressed by the SPR blockade.	Nitrates	35-42	sepiapterin reductase	Rattus norvegicus	136-139
12956537-5	2003	Experiments with various nitrogen supply regimes demonstrated the induction of NRT2.1 expression by nitrate and repression by amino acids.	Nitrates	100-107	nitrate transporter 2:1	Arabidopsis thaliana	79-83
12956537-0	2003	Regulation of the nitrate transporter gene AtNRT2.1 in Arabidopsis thaliana: responses to nitrate, amino acids and developmental stage.	Nitrates	18-25	nitrate transporter 2:1	Arabidopsis thaliana	43-51
12956537-7	2003	Taken together, our results support the hypothesis that the NRT2.1 gene codes for a major component of the inducible high-affinity transport system for nitrate, which is spatially and developmentally controlled at the transcriptional level.	Nitrates	152-159	nitrate transporter 2:1	Arabidopsis thaliana	60-66
12809317-1	2003	Denitrification, the anaerobic microbial conversion of nitrate (NO3-) to nitrogen (N) gases, is an important process contributing to the ability of riparian zones to function as "sinks" for NO3- in watersheds.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	64-67
12809317-1	2003	Denitrification, the anaerobic microbial conversion of nitrate (NO3-) to nitrogen (N) gases, is an important process contributing to the ability of riparian zones to function as "sinks" for NO3- in watersheds.	Nitrates	55-62	NBL1, DAN family BMP antagonist	Homo sapiens	190-193
12686872-10	2003	This change in erectile function was a result of eNOS over expression with an increase in eNOS protein expression and constitutive NOS activity as well as an increase in nitric oxide biosynthesis, as reflected by an increase in cavernous nitrate plus nitrite formation.	Nitrates	238-245	nitric oxide synthase 3	Rattus norvegicus	49-53
14659339-7	2003	In the metastatic disease group, there was a positive correlation between serum VEGF levels and nitrate+nitrite levels (r=0.436, P&lt;0.05).	Nitrates	96-103	vascular endothelial growth factor A	Homo sapiens	80-84
12654474-5	2003	In contrast, chemiluminescence analysis, which detects NO, NO2-, and nitrate (NO3-) (collectively referred to as NO(x)), detected significant increases in NO(x) from stimulated PAEC.	Nitrates	69-76	NBL1, DAN family BMP antagonist	Homo sapiens	78-81
12806280-1	2003	Activated monocytes-macrophages may be associated with antitumor activity, and activation of these cells by certain cytokines, primarily interferon gamma (IFN-gamma), can be indicated by alterations in the concentrations of neopterin, nitrate, or tryptophan.	Nitrates	235-242	interferon gamma	Homo sapiens	137-164
15270349-4	2003	Further, it was also found during study that, 16.00% of the borewell samples analyzed, were found to contain more than 100.00 PPM of nitrates (measured as NO3 mg/L, safe limit prescribed by BIS).	Nitrates	133-141	NBL1, DAN family BMP antagonist	Homo sapiens	155-158
12756917-8	2003	Nitrate reductase activity in bacteroids along nodule growth decreased in all groups including the ineffective AN group, whose nodulation was highly inhibited by nitrate at 5 mmol/L N. Host-cultivar interaction seemed to influence the regulation of nitrate reductase activity in bacteroids.	Nitrates	162-169	inducible nitrate reductase [NADH] 1	Glycine max	0-17
12708697-4	2003	A nitrate plume in shallow ground water with concentrations exceeding 10 mg NO3-N L(-1) moved into the restored forested riparian wetland.	Nitrates	2-9	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
12615686-8	2003	Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin.	Nitrates	127-134	glucose-6-phosphate dehydrogenase	Bos taurus	18-22
12615686-8	2003	Overexpression of G6PD was also associated with enhanced nitric oxide synthase activity, resulting in elevated levels of cGMP, nitrate, and nitrite, and this response was increased after stimulation with bradykinin.	Nitrates	127-134	kininogen 1	Bos taurus	204-214
12646747-6	2003	Intravitreal ET-1 significantly elevated the levels of nitrate to 189% of baseline 10 min after ET-1 application, which was inhibited by pretreatment of intravenous L-NAME (50 mg/kg).	Nitrates	55-62	endothelin-1	Oryctolagus cuniculus	13-17
12584267-10	2003	Correspondingly, urinary nitrate/nitrite excretion was significantly elevated in ET-1 transgenic mice.	Nitrates	25-32	endothelin 1	Mus musculus	81-85
12646747-6	2003	Intravitreal ET-1 significantly elevated the levels of nitrate to 189% of baseline 10 min after ET-1 application, which was inhibited by pretreatment of intravenous L-NAME (50 mg/kg).	Nitrates	55-62	endothelin-1	Oryctolagus cuniculus	96-100
12644691-6	2003	In contrast, the Aox1 expression is strongly dependent on the nitrogen source, being down-regulated by ammonium and stimulated by nitrate.	Nitrates	130-137	uncharacterized protein	Chlamydomonas reinhardtii	17-21
12668777-0	2003	Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision.	Nitrates	80-87	nitrate transporter 1.1	Arabidopsis thaliana	14-18
12668777-0	2003	Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision.	Nitrates	80-87	nitrate transporter 2:1	Arabidopsis thaliana	23-27
12668777-6	2003	Expression of AtNRT2.5, one of the nitrate-repressible genes, was strongly suppressed by nitrate provision in both roots and shoots.	Nitrates	35-42	nitrate transporter2.5	Arabidopsis thaliana	14-22
12668777-6	2003	Expression of AtNRT2.5, one of the nitrate-repressible genes, was strongly suppressed by nitrate provision in both roots and shoots.	Nitrates	89-96	nitrate transporter2.5	Arabidopsis thaliana	14-22
12644691-8	2003	The stimulation by nitrate also occurs at the AOX protein and respiratory levels.	Nitrates	19-26	uncharacterized protein	Chlamydomonas reinhardtii	46-49
12644691-10	2003	The observed pattern of AOX regulation points to the possible interaction between chloroplast and mitochondria in relation to a potential increase of photogenerated ATP when nitrate is used as a nitrogen source.	Nitrates	174-181	uncharacterized protein	Chlamydomonas reinhardtii	24-27
12549937-10	2003	Thus, XOR catalyzed nitrate reduction to nitrite and NO occurs and can be an important source of NO production in ischemic tissues.	Nitrates	20-27	xanthine dehydrogenase	Homo sapiens	6-9
15055718-9	2003	On the other hand, long-term treatment with this AT1 receptor antagonist produced a significant increase of nitrate/nitrite and cGMP plasma levels.	Nitrates	108-115	angiotensin II receptor, type 1a	Rattus norvegicus	49-52
12527339-6	2003	resulted in a significant reduction of the expression of iNOS protein in rat lung tissue and in the plasma nitrite/nitrate (NOx) level.	Nitrates	115-122	nitric oxide synthase 2	Rattus norvegicus	57-61
12563676-10	2003	The serum nitrite/nitrate levels, histological grades of articular cartilage degradation, and numbers of apoptotic chondrocytes and nitrotyrosine positive chondrocytes were significantly lower in NOS2-/- mice with AMA than in WT mice with AMA.	Nitrates	18-25	nitric oxide synthase 2, inducible	Mus musculus	196-200
12500206-7	2003	Among ascitic patients, those with high LBP showed greater (P &lt;.05) levels of sCD14, tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), nitrites + nitrates (NOx)/creatinine, and renin, and lower vascular resistance.	Nitrates	162-170	lipopolysaccharide binding protein	Homo sapiens	40-43
12693036-4	2003	We find that peroxynitrite selectively nitrates Tyr99 at physiological pH, resulting in the formation of between 0.05 and 0.25 mol of nitrotyrosine/mol of CaM when the added molar ratio of peroxynitrite per CaM was varied between 2.5 and 1.5.	Nitrates	39-47	calmodulin 1	Homo sapiens	155-158
12653221-4	2003	Water-immersion-restraint stress (WIRS) increased myeloperoxidase (MPO) activity in gastric mucosa and induced hemorrhagic erosions by a nitrate-inhibitable mechanism.	Nitrates	137-144	myeloperoxidase	Rattus norvegicus	67-70
12647538-2	2003	Mercury iodide and nitrate contribute more to inhibiting cathepsin B and calpains activities in the above tissues, respectively.	Nitrates	19-26	cathepsin B	Rattus norvegicus	57-68
12602959-5	2003	NO is an extremely unstable molecule and rapidly converted in vivo and in vitro to nitrate (NO3-) and nitrite (NO2-).	Nitrates	83-90	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
12509525-7	2003	At the cellular level, chl1 mutants showed reduced nitrate accumulation in guard cells during stomatal opening and failed to show nitrate-induced depolarization of guard cells.	Nitrates	51-58	cell adhesion molecule L1 like	Homo sapiens	23-27
12685047-2	2003	In maize, a C4 plant, expression of genes for the non-photosynthetic isoproteins, Fd VI and R-FNR, is responsive to nitrate in roots whereas the expression and the spatial distribution in the leaves have not been analysed.	Nitrates	116-123	ferredoxin-6, chloroplastic	Zea mays	82-87
12685047-4	2003	Upon addition of nitrate, the transcripts for Fd VI and R-FNR rapidly accumulated in the leaves, whereas light did not induce accumulation.	Nitrates	17-24	ferredoxin-6, chloroplastic	Zea mays	46-51
12685047-6	2003	In the leaf, the transcripts for Fd VI and R-FNR were predominantly detected in mesophyll cells as were those for nitrate-assimilatory enzymes.	Nitrates	114-121	ferredoxin-6, chloroplastic	Zea mays	33-38
12906266-3	2003	Results of the study showed various heterotrophic bacteria to be capable of anoxic P accumulation utilising nitrate (NO3) as electron acceptor.	Nitrates	108-115	NBL1, DAN family BMP antagonist	Homo sapiens	117-120
12906301-6	2003	Anaerobic H2S oxidation with NO3- was also induced by addition of nitrate to the medium.	Nitrates	66-73	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
14682566-3	2003	However, based on this SCOD removal in the nitrification step, a consequent post-denitrification process without nitrate recycle and dosage of external carbon sources has been proven to reach substantial nitrate elimination of up to 20 mg nitrogen per litre at COD/N-ratios of approx.	Nitrates	204-211	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	24-27
12509525-9	2003	These results identify an anion transporter that functions in stomatal opening and demonstrate that CHL1 supports stomatal function in the presence of nitrate.	Nitrates	151-158	cell adhesion molecule L1 like	Homo sapiens	100-104
12487131-3	2002	This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride/nitrate-selectivity.	Nitrates	127-134	frataxin	Homo sapiens	41-46
12488138-7	2002	Collectively, our results suggest that MPO released by activated neutrophils during inflammation utilizes physiological or pathological levels of NO 2 - to nitrate proteins, and may provide an additional mechanism in addition to ONOO - formation, for tissue injury in ARDS and other inflammatory diseases associated with upregulated *NO and oxidant production.	Nitrates	156-163	myeloperoxidase	Homo sapiens	39-42
12442170-8	2002	HAR1 encodes a putative serine/threonine receptor kinase, which is required for shoot-controlled regulation of root growth, nodule number, and for nitrate sensitivity of symbiotic development.	Nitrates	147-154	CM0216.560.nc	Lotus japonicus	0-4
12194970-6	2002	Our studies demonstrate that levels of nitric oxide that are likely to be encountered in the vicinity of airway cells during inflammation may nitrate CFTR resulting in enhanced degradation and decreased function.	Nitrates	142-149	CF transmembrane conductance regulator	Homo sapiens	150-154
12390892-1	2002	Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration.	Nitrates	33-40	nitric oxide synthase 2	Homo sapiens	142-173
12390892-1	2002	Recently, we have found that the nitrate/nitrite concentrations in preovulatory follicles significantly decrease after hCG injection and that inducible nitric oxide synthase (iNOS) plays a main role in the decrease of the intrafollicular nitric oxide (NO) concentration.	Nitrates	33-40	nitric oxide synthase 2	Homo sapiens	175-179
12270552-3	2002	In this study, we show the varying concentrations of nitrite and nitrate present in different body fluids during AK-5 tumor growth and regression in Wistar rats.	Nitrates	65-72	adenylate kinase isoenzyme 5	Rattus norvegicus	113-117
12411410-5	2002	After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium.	Nitrates	160-167	leptin	Mus musculus	26-32
12411410-5	2002	After 24 h of incubation, leptin (1-10 micro g ml(-1)) potently synergized with IFN-gamma (100 U ml(-1)) in nitric oxide (NO) release, evaluated as nitrite and nitrate (NO(x)), and prostaglandin E(2) (PGE(2)) production in culture medium.	Nitrates	160-167	interferon gamma	Mus musculus	80-89
12433163-1	2002	Riparian zones have been found to function as "sinks" for nitrate (NO3-), the most common groundwater pollutant in the U. S., in many areas.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
12436367-8	2002	The connection between increased nitric oxide production and the haemodynamic sequelae of portal hypertension is also apparent in the significant correlation between plasma renin and serum nitrate levels.	Nitrates	189-196	renin	Homo sapiens	173-178
12436367-9	2002	Circulating nitrate levels also correlated to the serum interleukin-6 levels.	Nitrates	12-19	interleukin 6	Homo sapiens	56-69
12177001-10	2002	Our studies indicate that AQP6 exhibits a new form of anion permeation with marked specificity for nitrate conferred by a specific pore-lining residue, observations that imply that the primary role of AQP6 may be in cellular regulation rather than simple fluid transport.	Nitrates	99-106	aquaporin 6	Homo sapiens	26-30
12177001-10	2002	Our studies indicate that AQP6 exhibits a new form of anion permeation with marked specificity for nitrate conferred by a specific pore-lining residue, observations that imply that the primary role of AQP6 may be in cellular regulation rather than simple fluid transport.	Nitrates	99-106	aquaporin 6	Homo sapiens	201-205
12382055-8	2002	Phenotype analysis showed that the moeA gene is required for A. mediterranei growth in a minimal medium with nitrate as sole nitrogen source, possibly because nitrate reductase activity is diminished due to disruption of the moeA gene.	Nitrates	109-116	molybdopterin molybdotransferase MoeA	Amycolatopsis mediterranei U32	35-39
12384050-8	2002	The most advantageous configuration tested, where nitrate assimilation (as well as that of ammonium) continued at a high rate in darkness as long as C-reserves remained, is not actually used in migratory species but in non-migratory diatoms.	Nitrates	50-57	steroid sulfatase	Homo sapiens	146-150
12202921-8	2002	Because nitrate/nitrite shifted the balance from a Th1 to a Th2 response in some individuals, exposure to these compounds may decrease these persons" responsiveness to infectious diseases.	Nitrates	8-15	negative elongation factor complex member C/D	Homo sapiens	51-54
12298004-3	2002	The magneto-switchable activation and deactivation of the electrochemical oxidation of the ferrocene-functionalized magnetic particles and the electrochemical reduction of the bipyridinium-functionalized magnetic particles are used for the triggering of mediated bioelectrocatalytic oxidation of glucose, in the presence of glucose oxidase (GOx), and bioelectrocatalytic reduction of nitrate (NO(3) (-)), in the presence of nitrate reductase (NR), respectively.	Nitrates	384-391	hydroxyacid oxidase 1	Homo sapiens	324-339
12298004-3	2002	The magneto-switchable activation and deactivation of the electrochemical oxidation of the ferrocene-functionalized magnetic particles and the electrochemical reduction of the bipyridinium-functionalized magnetic particles are used for the triggering of mediated bioelectrocatalytic oxidation of glucose, in the presence of glucose oxidase (GOx), and bioelectrocatalytic reduction of nitrate (NO(3) (-)), in the presence of nitrate reductase (NR), respectively.	Nitrates	384-391	hydroxyacid oxidase 1	Homo sapiens	341-344
12208366-6	2002	Of special interest has been the finding that XOR can catalyze the reduction of nitrates and nitrites to nitric oxide (NO), acting as a source of both NO and peroxynitrite.	Nitrates	80-88	xanthine dehydrogenase	Homo sapiens	46-49
12369617-3	2002	Using this vector a plant nitrate reductase cDNA (tobacco Nia2) was expressed for the first time in a nitrate assimilatory yeast.	Nitrates	26-33	nitrate reductase [NADH] 2	Nicotiana tabacum	58-62
12230634-6	2002	The decreased insulin response was associated with significant elevation of nitric oxide produced from GSNO and SNAP co-administered with vitamin C, as assessed by plasma nitrate/nitrite levels.	Nitrates	171-178	insulin	Canis lupus familiaris	14-21
12358336-9	2002	In iNOS-deficient mice, both iNOS expression and NT formation were completely abolished, and the total amounts of nitrite and nitrate in BAL fluid were significantly decreased.	Nitrates	126-133	nitric oxide synthase 2, inducible	Mus musculus	3-7
12396394-7	2002	The estimated median intake of lead and nitrate per kg body weight from tap water was higher in FF infants than in BF infants or mixed fed (MF) young children.	Nitrates	40-47	USO1 vesicle transport factor	Homo sapiens	72-75
12226143-6	2002	RESULTS: Leptin increased plasma concentrations of NO metabolites (nitrates + nitrites, NO(x)) by 32.5%, 58.0%, and 29.7% at 1, 2, and 4 hours, respectively.	Nitrates	67-75	leptin	Rattus norvegicus	9-15
12171788-3	2002	METHODS AND RESULTS: After gene transfer, expression of eNOS in cultured cells was detected by increased intracellular cGMP and nitrate/nitrite levels and NO synthase activity.	Nitrates	128-135	nitric oxide synthase 3	Rattus norvegicus	56-60
12196158-8	2002	Prior investigations have shown that the absence of CymA results in loss of the ability to respire with Fe(III), fumarate and nitrate, indicating that CymA is involved in electron transfer to several terminal reductases.	Nitrates	126-133	cytochrome c	Shewanella oneidensis MR-1	52-56
12196158-8	2002	Prior investigations have shown that the absence of CymA results in loss of the ability to respire with Fe(III), fumarate and nitrate, indicating that CymA is involved in electron transfer to several terminal reductases.	Nitrates	126-133	cytochrome c	Shewanella oneidensis MR-1	151-155
12192137-1	2002	The rare earth metal(III) trifluoromethanesulfonate (rare earth metal(III) triflate, RE(OTf)3) was found to be an efficient catalyst for aromatic nitration with carboxylic anhydride-inorganic nitrate as the nitrating agent.	Nitrates	192-199	POU class 5 homeobox 1	Homo sapiens	85-93
12196104-9	2002	The increase in NR activity resulted in a significant decrease in nitrate level.	Nitrates	66-73	NADH nitrate reductase	Solanum tuberosum	16-18
12193069-0	2002	Comparison of the effects of atherosclerosis and nitrate therapy on responses to nitric oxide and endothelin-1 in human arteries in vitro.	Nitrates	49-56	endothelin 1	Homo sapiens	98-110
12193069-1	2002	The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro.	Nitrates	23-30	endothelin 1	Homo sapiens	64-76
12193069-1	2002	The effect of previous nitrate therapy on vascular responses to endothelin-1 (ET-1) and NO was investigated in human internal mammary artery (IMA) in vitro.	Nitrates	23-30	endothelin 1	Homo sapiens	78-82
12165428-3	2002	The genes YNT1, YNR1 and YNI1, encoding respectively nitrate transport, nitrate reductase and nitrite reductase, have been cloned, as well as two other genes encoding transcriptional regulatory factors.	Nitrates	53-60	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	10-14
12139615-9	2002	The promoters of most of these Dam-controlled genes were also found to contain GATC sequences that overlap with recognition sites for two global regulators, fumarate nitrate reduction (Fnr) and catabolite activator protein (CRP).	Nitrates	166-173	catabolite gene activator protein	Escherichia coli	194-228
12172843-4	2002	The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation.	Nitrates	132-139	uncharacterized protein	Chlamydomonas reinhardtii	213-217
12172843-1	2002	The expression of nitrite uptake activity and the induction of transcripts from several nitrate assimilation genes (Nii1, Nrt2;1, Nrt2;3, and Nar1) have been analysed in Chlamydomonas reinhardtii Dang.	Nitrates	88-95	uncharacterized protein	Chlamydomonas reinhardtii	116-120
12172843-4	2002	The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation.	Nitrates	132-139	uncharacterized protein	Chlamydomonas reinhardtii	213-217
12172843-4	2002	The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation.	Nitrates	34-41	uncharacterized protein	Chlamydomonas reinhardtii	213-217
12172843-4	2002	The presence of the high-affinity nitrate transport system I (NRT2;1, NAR2) made cells able to sense the very low concentrations of nitrate present in culture medium with no added nitrate and to express optimally Nii1, Nrt2;1, Nrt2;3, and Nar1 genes involved in nitrate/nitrite assimilation.	Nitrates	132-139	uncharacterized protein	Chlamydomonas reinhardtii	213-217
12230195-1	2002	A novel in situ membrane technology was developed to remove nitrate (NO3-) from groundwater.	Nitrates	60-67	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
12198187-6	2002	The astray seedlings showed normal sensitivity to the general inhibitors of nodulation such as ethylene and nitrate.	Nitrates	108-115	ASTRAY	Lotus japonicus	4-10
12052727-1	2002	Nitrites and nitrates are widely used reporters of endogenous activity of nitric oxide synthases (NOS), an important group of enzymes producing the gaseous signal molecule nitric oxide (NO).	Nitrates	13-21	nitric oxide synthase 2	Homo sapiens	74-96
12099927-6	2002	Interestingly, we observed a significant negative correlation between IL-6 and nitrite/nitrate levels in the CSF in the total MS group.	Nitrates	87-94	interleukin 6	Homo sapiens	70-74
12069938-6	2002	TNF-alpha caused significant inhibition of ACh- and bradykinin-induced vascular relaxation and nitrite/nitrate production that were more prominent in pregnant than virgin rats.	Nitrates	103-110	tumor necrosis factor	Rattus norvegicus	0-9
12093672-5	2002	Levels of nitrite and/or nitrate in the serum were elevated within 2 h after administration of IL-18, reaching a peak at 4 h and then decreasing gradually to the basal level over a 24-h period of time.	Nitrates	25-32	interleukin 18	Mus musculus	95-100
12115884-6	2002	Induction of iNOS was confirmed by measurement of nitrate/nitrite production and by immunodetection.	Nitrates	50-57	nitric oxide synthase 2	Homo sapiens	13-17
12127127-9	2002	Plasma and intestinal levels of the nitric oxide products, nitrite/nitrate, were increased in the iNOS +/+ mice fed the TPN solution but not in the chow-fed groups or the iNOS -/- mice receiving TPN solution.	Nitrates	67-74	nitric oxide synthase 2, inducible	Mus musculus	98-102
12068127-4	2002	Using a reverse genetic approach, the AtNRT2.1 gene has been shown to be involved in the inducible component of the high-affinity nitrate transport system in Arabidopsis.	Nitrates	130-137	nitrate transporter 2:1	Arabidopsis thaliana	38-46
12154133-8	2002	The expression of the three genes was also induced by nitrate supplement but the induction was most prominent and transient in AtpOMT1 similar to nitrate reductase gene.	Nitrates	54-61	nitrate reductase 1	Arabidopsis thaliana	146-163
12044161-0	2002	Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism.	Nitrates	53-60	cyclin dependent kinase 2	Homo sapiens	30-34
12044161-0	2002	Structural studies on phospho-CDK2/cyclin A bound to nitrate, a transition state analogue: implications for the protein kinase mechanism.	Nitrates	53-60	cyclin A2	Homo sapiens	35-43
12044161-3	2002	The crystal structure of pCDK2/cyclin A in complex with Mg(2+)ADP, nitrate, and a heptapeptide substrate has been determined at 2.7 A.	Nitrates	67-74	cyclin A2	Homo sapiens	31-39
12044161-6	2002	Kinetic studies demonstrate that nitrate is not an effective inhibitor of protein kinases, consistent with the structural results that show the nitrate ion makes few stabilizing interactions with CDK2 at the catalytic site.	Nitrates	144-151	cyclin dependent kinase 2	Homo sapiens	196-200
12003849-0	2002	Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II.	Nitrates	35-42	angiotensinogen	Rattus norvegicus	69-83
12003849-7	2002	Control responses were restored by SOD, MnTBAP, or losartan, suggesting a role for elevated angiotensin II and reactive oxygen species (ROS) as mediators of the attenuated NO dilation (nitrate tolerance).	Nitrates	185-192	angiotensinogen	Rattus norvegicus	92-106
12003849-9	2002	In summary, terminal arterioles are affected by nitrates to a greater extent than the arcade arterioles that feed them, in a process dependent on angiotensin II and ROS.	Nitrates	48-56	angiotensinogen	Rattus norvegicus	146-160
12087347-2	2002	Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance.	Nitrates	74-81	renin	Homo sapiens	18-23
12087347-2	2002	Activation of the renin-angiotensin system by heart failure itself and by nitrate therapy may be one possible mechanism underlying nitrate tolerance.	Nitrates	131-138	renin	Homo sapiens	18-23
12087347-8	2002	CONCLUSION: Our results suggest that angiotensin II may attenuate the arterial vasodilating effect of glyceryl trinitrate through angiotensin type 1 receptors and presumably through receptor-mediated superoxide production, which may be relevant to the development of nitrate tolerance.	Nitrates	114-121	angiotensinogen	Homo sapiens	37-51
12058245-4	2002	Thus, nitrates enhance the production of cyclic GMP and combined with phosphodiesterase type-5 inhibitors this can lead to severe hypotension.	Nitrates	6-14	5'-nucleotidase, cytosolic II	Homo sapiens	48-51
11943658-3	2002	Incubation of transplant AMs with SP-A increased intracellular Ca(2+) concentration ([Ca(2+)](i)) by 70% and nitrite and nitrate (NO(x)) production by 45% (from 0.24 +/- 0.02 to 1.3 +/- 0.21 nmol small middle dot 10(6) AMs(-1).h(-1)).	Nitrates	121-128	surfactant protein A1	Homo sapiens	34-38
12060247-9	2002	We were able to restore wild-type levels of NRA in ipt-expressing plants by simultaneous induction of NR with BA and nitrate.	Nitrates	117-124	Ipt	Agrobacterium tumefaciens	51-54
12006803-10	2002	Increased serum nitrate (micromoles of NO2 + NO3) concentrations were detected in septic patients, compared with controls, but no differences were found between survivor (91.84 +/- 14.12) and nonsurvivor (102.6 +/- 17.36) groups.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
11976082-4	2002	Insertional inactivation of the nitrite reductase structural gene or its transcriptional regulator, NnrR, in strain 2.4.3 caused a loss of a taxis response towards both nitrate and nitrite.	Nitrates	169-176	AWN88_RS06525	Agrobacterium tumefaciens	32-49
12000675-0	2002	Nitrate signalling on the nitrate reductase gene promoter depends directly on the activity of the nitrate transport systems in Chlamydomonas.	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	26-43
12021246-9	2002	Our observations provide strong evidence that myeloperoxidase generates reactive nitrogen species in vivo and that it operates in this fashion only when nitrite and nitrate become available.	Nitrates	165-172	myeloperoxidase	Mus musculus	46-61
12061138-6	2002	Nicorandil, a hybrid of an ATP sensitive K+ (KATP) channel opener and nitrate, increases the level of interstitial adenosine via cGMP-mediated activation of ecto-5"-nucleotidase.	Nitrates	70-77	5' nucleotidase, ecto	Rattus norvegicus	157-177
12000675-1	2002	Nitrate signalling on the nitrate reductase (Nia1) gene promoter from Chlamydomonas reinhardtii has been studied by using a construct of the Nia1 promoter transcriptionally fused to the Chlamydomonas arylsulphatase gene as a reporter in strains bearing different sets of nitrate/nitrite transport genes.	Nitrates	0-7	uncharacterized protein	Chlamydomonas reinhardtii	26-43
12010476-9	2002	The results may mean that AMF-colonization positively affects nitrate uptake from soil and nitrate allocation to the plant partner, probably mediated preferentially by LeNRT2;3.	Nitrates	62-69	nitrate transporter NRT2.3	Solanum lycopersicum	168-176
12010476-9	2002	The results may mean that AMF-colonization positively affects nitrate uptake from soil and nitrate allocation to the plant partner, probably mediated preferentially by LeNRT2;3.	Nitrates	91-98	nitrate transporter NRT2.3	Solanum lycopersicum	168-176
12133319-16	2002	(4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P &lt; 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P &gt; 0.05).	Nitrates	92-100	matrix metallopeptidase 2	Rattus norvegicus	61-66
12059056-5	2002	In addition, iNOS expression in circulating monocytes was assessed by Western blotting, immunocytochemistry and measurement of the NO metabolites nitrite and nitrate in plasma.	Nitrates	158-165	nitric oxide synthase 2	Homo sapiens	13-17
12133319-16	2002	(4) A significant positive correlation was found between the MMP-2 mRNA levels and nitrites/nitrates levels in L-arginine group and asthmatic group (r(s) = 0.65, 0.68, P &lt; 0.05), but there was no significant correlation between the nitrites/nitrates levels and the TIMP-1 mRNA levels in the two groups (r(s) = 0.23, 0.18, P &gt; 0.05).	Nitrates	244-252	matrix metallopeptidase 2	Rattus norvegicus	61-66
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	126-133	radixin	Homo sapiens	160-163
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	16-23	radixin	Homo sapiens	42-45
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	126-133	radixin	Homo sapiens	160-163
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	126-133	radixin	Homo sapiens	42-45
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	126-133	radixin	Homo sapiens	160-163
12153019-9	2002	The presence of nitrate reversibly halted RDX metabolism, whereas ammonium had no discernible effect, which implies that: (i) nitrate, which commonly occurs in RDX-contaminated groundwater, may inhibit in situ RDX metabolism, and (ii) although RDX may act as both a nitrogen source and cometabolic electron sink, the latter role predominates, as RDX reduction will proceed regardless of whether or not a more favorable nitrogen source is present.	Nitrates	126-133	radixin	Homo sapiens	160-163
12081242-10	2002	We concluded that the decrease in nitrate/nitrite concentration in preovulatory follicles after hCG injection was due mainly to decreased iNOS expression in granulosa cells.	Nitrates	34-41	nitric oxide synthase 2	Rattus norvegicus	138-142
11939777-2	2002	The NapB protein is essential in transferring electrons to the large catalytic subunit NapA, which subsequently reduces nitrate to nitrite.	Nitrates	120-127	NSF attachment protein beta	Homo sapiens	4-8
11939777-8	2002	We propose a hypothetical but plausible model of the NapAB complex in which the four redox centers are positioned in a virtually linear configuration which spans a distance of nearly 40 A, suggesting an efficient pathway for the transfer of electrons from NapC, the physiological electron donor of NapB, to a nitrate molecule at the catalytic site of NapA.	Nitrates	309-316	NSF attachment protein beta	Homo sapiens	298-302
11912238-4	2002	Later in the diurnal cycle an orchestrated increase of GLN2, PKc, CS, and ICDH-1 expression re-establishes a balance between nitrate assimilation and ammonium metabolism.	Nitrates	125-132	glucan endo-1,3-beta-glucosidase, basic vacuolar	Nicotiana tabacum	55-59
11912225-2	2002	Two classes of genes, NRT1 and NRT2, have been found to be potentially involved in the high and low affinity nitrate transport systems (HATS and LATS, respectively).	Nitrates	109-116	nitrate transporter 1.1	Arabidopsis thaliana	22-26
11954828-7	2002	PARP-/- mice, and their wild-type littermate showed a similar time-dependent increase in plasma nitrite/nitrate and in gut and lung MDA content, as well as the presence of nitrotyrosine in the gut.	Nitrates	104-111	poly (ADP-ribose) polymerase family, member 1	Mus musculus	0-4
11912225-2	2002	Two classes of genes, NRT1 and NRT2, have been found to be potentially involved in the high and low affinity nitrate transport systems (HATS and LATS, respectively).	Nitrates	109-116	nitrate transporter 2:1	Arabidopsis thaliana	31-35
11912225-3	2002	The complexity of the molecular basis of nitrate uptake has been enhanced by the finding that in many plants both NRT1 and NRT2 classes are represented by multigene families.	Nitrates	41-48	nitrate transporter 1.1	Arabidopsis thaliana	114-118
11912225-3	2002	The complexity of the molecular basis of nitrate uptake has been enhanced by the finding that in many plants both NRT1 and NRT2 classes are represented by multigene families.	Nitrates	41-48	nitrate transporter 2:1	Arabidopsis thaliana	123-127
11912225-5	2002	This is a review of recent progress in the characterization of the NRT2 nitrate transporters, the composition of this family in Arabidopsis, their possible role in nitrate acquisition, and some aspects of their regulation in plants.	Nitrates	72-79	nitrate transporter 2:1	Arabidopsis thaliana	67-71
11912226-1	2002	The AtNRT1.1 (CHL1) gene of Arabidopsis encodes a dual-affinity nitrate transporter and contributes to both low and high affinity nitrate uptake.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	4-12
11912226-1	2002	The AtNRT1.1 (CHL1) gene of Arabidopsis encodes a dual-affinity nitrate transporter and contributes to both low and high affinity nitrate uptake.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	14-18
11912227-4	2002	In Chlamydomonas reinhardtii, the Nar1;1 gene has been shown to have this role in nitrate assimilation.	Nitrates	82-89	NAR1.1	Chlamydomonas reinhardtii	34-40
11922726-1	2002	The nitrate form of the Group III transitional element gallium (GN) increases expression of specific structural components of the provisional wound matrix (i.e., collagen type I, fibronectin) in human dermal fibroblasts.	Nitrates	4-11	fibronectin 1	Homo sapiens	179-190
11921102-1	2002	Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha.	Nitrates	0-7	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	59-63
11921102-1	2002	Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha.	Nitrates	0-7	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	164-168
11921102-1	2002	Nitrate assimilation genes encoding a nitrate transporter (YNT1), nitrite reductase (YNI1), a Zn(II)(2)Cys(6) transcriptional factor involved in nitrate induction (YNA1) and the nitrate reductase (YNR1) are clustered in the yeast Hansenula polymorpha.	Nitrates	38-45	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	164-168
11814459-5	2002	There was a weak but significant correlation between the nitrite/nitrate and endothelin-1 concentrations in the NP and NTP groups (r(1)=0.46, P&lt;0.05, and r(2)=0.38, P&lt;0.05, respectively) which probably revealed the balance between these vasoactive factors.	Nitrates	65-72	endothelin 1	Homo sapiens	77-89
11823513-7	2002	Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels.	Nitrates	220-227	interleukin 12b	Mus musculus	9-17
11990929-10	2002	The nitrate concentration change was paralleled by the systemic inflammatory response syndrome, as indicated by alterations of myeloperoxidase activity and by impaired histologic and cellular membrane integrity in tissues and organs.	Nitrates	4-11	myeloperoxidase	Rattus norvegicus	127-142
12148533-12	2002	The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response.	Nitrates	112-119	Transmembrane amino acid transporter family protein	Arabidopsis thaliana	43-47
11878390-2	2002	This method is similar to U.S. Environmental Protection Agency method 353.2 and U.S. Geological Survey method 1-2545-90 except that nitrate is reduced to nitrite by soluble nitrate reductase (NaR, EC 1.6.6.1) purified from corn leaves rather than a packed-bed cadmium reactor.	Nitrates	132-139	nitrate reductase [NADH] 1	Zea mays	173-190
11823513-7	2002	Infected IL-12p40(-/-) and IFN-gamma(-/-) mice also mounted anti-Citrobacter serum and gut-associated IgA responses and strongly expressed inducible NO synthase (iNOS) in mucosal tissue, despite diminished serum nitrite/nitrate levels.	Nitrates	220-227	interferon gamma	Mus musculus	27-36
11792648-8	2002	Basal and ACh-induced nitrite/nitrate production was less in TNF-alpha-infused than in control pregnant rats.	Nitrates	30-37	tumor necrosis factor	Rattus norvegicus	61-70
11863253-6	2002	RESULTS: A twofold increase in plasma TNF-alpha levels in pregnant rats resulted in a significant increase in arterial pressure (97 +/- 3.6 v 116 +/- 2.1 mm Hg, pregnant versus TNF-alpha pregnant, respectively, P &lt; .05), but no significant change in urinary nitrite/nitrate excretion (22.0 +/- 1.9 v 20.8 +/- 2.5 micromol/24 h, pregnant versus TNF-alpha pregnant, respectively), a measure of whole body NO production.	Nitrates	269-276	tumor necrosis factor	Rattus norvegicus	38-47
11858480-6	2002	RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p &lt;0.05), the development of MOF (p &lt;0.05), and mortality (p &lt;0.05).	Nitrates	118-125	coagulation factor III, tissue factor	Homo sapiens	19-21
11858480-6	2002	RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p &lt;0.05), the development of MOF (p &lt;0.05), and mortality (p &lt;0.05).	Nitrates	118-125	serpin family E member 1	Homo sapiens	26-31
11858480-6	2002	RESULTS: Increased TF and PAI-1 antigen, and PAI-1 activity levels were associated with increasing IL-6 and nitrite + nitrate levels (p &lt;0.05), the development of MOF (p &lt;0.05), and mortality (p &lt;0.05).	Nitrates	118-125	serpin family E member 1	Homo sapiens	45-50
12442789-1	2002	This paper assesses the distribution of ammonium (NH4+) and nitrate (NO3-) nitrogen deposition in native bushland soil adjacent to an open ventilated poultry farm.	Nitrates	60-67	NBL1, DAN family BMP antagonist	Homo sapiens	69-72
11755929-4	2002	Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs.	Nitrates	113-120	interleukin 1 beta	Rattus norvegicus	5-13
11755929-4	2002	Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate (NOx) production in rat VSMCs.	Nitrates	113-120	tumor necrosis factor	Rattus norvegicus	18-27
11924581-4	2002	The nitrate removal rate per unit volume of sulfur layer can be expressed as alpha (ALR)n, where ALR is the applied loading rate.	Nitrates	4-11	growth factor, augmenter of liver regeneration	Homo sapiens	84-87
11924581-4	2002	The nitrate removal rate per unit volume of sulfur layer can be expressed as alpha (ALR)n, where ALR is the applied loading rate.	Nitrates	4-11	growth factor, augmenter of liver regeneration	Homo sapiens	97-100
12077491-12	2002	In multivariate analysis, significant independent predictors of fDH were older age (OR = 1.04 [1.02-1.07]), lack of glomerulonephritis as renal diagnosis (2.63 [1.18-5.87]), high phosphorus levels (5.0 [2.45-10.0]), lack of use of Ca-channel blockers (2.09 [1.12-3.91]), and the use of nitrates (2.38 [1.24-4.55]).	Nitrates	286-294	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	64-67
12638758-3	2002	The surface runoff was negligible and therefore the according nitrate fluxes as welL Soil water analysis revealed mean nitrate concentrations of 3 to 15 mg NO3 L(-1), depending on soil depth.	Nitrates	119-126	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
12638758-4	2002	The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
12638758-4	2002	The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
12638758-4	2002	The nitrate concentrations at 50 cm soil depth and the associated percolation rates led to NO3-N outputs of 15.9 kg NO3-N ha(-1) in the year 1999 and 7.9 kg NO3-N ha(-1) in the year 2000.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
12210732-7	2002	On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels.	Nitrates	96-103	interleukin 1 beta	Mus musculus	19-27
12210732-7	2002	On the other hand, IL-1beta, a Th1 proinflammatory cytokine, dramatically increases nitrite and nitrate levels, as well as inducible nitric oxide synthase (iNOS) transcripts and also upregulates islet ICAM-1 expression as well as circulating ICAM-1 levels.	Nitrates	96-103	negative elongation factor complex member C/D, Th1l	Mus musculus	31-34
11902126-2	2002	Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects.	Nitrates	152-159	6-pyruvoyltetrahydropterin synthase	Homo sapiens	14-50
11902126-2	2002	Patients with 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase and dihydropteridine reductase deficiencies exhibited decreased CSF nitrite + nitrate levels compared with healthy control subjects.	Nitrates	152-159	sepiapterin reductase	Homo sapiens	52-73
11793130-6	2002	Urinary nitrite + nitrate excretion was significantly lower in iNOS KO mice compared to control animals at all time points; in C57 mice, urinary nitrite declined progressively with more prolonged duration of diabetes.	Nitrates	18-25	nitric oxide synthase 2, inducible	Mus musculus	63-67
16228527-3	2002	The activity of nitrate reductase (NR), the first and rate-limiting step in the assimilation of nitrate into amino acids in leaves, is subjected to a varied range of regulatory influences including a robust circadian rhythm.	Nitrates	16-23	nitrate reductase [NADH]	Solanum lycopersicum	35-37
25696028-8	2002	Nitrates and NO-donors reduce SBP more than DBP because of their effects on the large conduit arteries.	Nitrates	0-8	selenium binding protein 1	Homo sapiens	30-33
12051519-7	2002	Endothelin-1 additions diminished nitrate and nitrite levels in embryos from both control and n-stz diabetic rats, whereas bosentan stimulated nitrate and nitrite generation in those embryos.	Nitrates	34-41	endothelin 1	Rattus norvegicus	0-12
11788764-3	2002	In leaves, GS2 functions to assimilate ammonia produced by nitrate reduction and photorespiration, and GS1 is the major isoform assimilating NH3 produced by all other metabolic processes, including symbiotic N2 fixation in the nodules.	Nitrates	59-66	glutamine synthetase precursor	Glycine max	11-14
12189042-10	2002	However, oxygenated myoglobin readily reacts with *NO to yield higher order N-oxides such as nitrate, while both the ferrous and ferric forms of the protein form a stable complex with *NO.	Nitrates	93-100	myoglobin	Homo sapiens	20-29
12688525-7	2002	The appearance and disappearance of P450 isoforms paralleled the conversion of organic nitrates to NO as assessed by immunohistochemistry and Western blotting.	Nitrates	87-95	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	36-40
12688525-2	2002	We studied the rat P450 (CYP)-catalyzed conversion of organic nitrate to nitric oxide (NO) by purified CYP isoforms and the relationship between P450 expression and nitrate tolerance following continuous infusion of organic nitrates in rats.	Nitrates	62-69	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	19-23
12688525-8	2002	Our observations indicate that nitrate tolerance is in large part the result of decreased P450 expression and activity.	Nitrates	31-38	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	90-94
11735412-7	2001	First, metHb prevents the peroxynitrite-mediated nitration of a target dipeptide, Ala-Tyr, and second, it promotes the isomerization of peroxynitrite to nitrate.	Nitrates	153-160	hemoglobin subunit gamma 2	Homo sapiens	7-12
12805744-1	2001	An investigation of air pollution in the Tehran metropolitan area between 1992-2000 indicated that there are significant amounts of nitrate ion (NO3-), over 30 kg/ha/year, deposited as wet deposition, compared to 13 kg/ha/year in the Chitgar Parkland near the Tehran metropolitan area.	Nitrates	132-139	NBL1, DAN family BMP antagonist	Homo sapiens	145-148
11936646-3	2002	Simulation studies using the Simulation Benchmark developed in the European COST program show that both objectives can be achieved by maintaining the nitrate concentration at the outlet of the anoxic zone at around 2 mgN/L.	Nitrates	150-157	helt bHLH transcription factor	Homo sapiens	217-220
11730359-9	2001	Plasma and urine nitrite/nitrate levels were significantly lower in l-NAME-treated Thy-1 rats compared to nontreated Thy-1 rats.	Nitrates	25-32	Thy-1 cell surface antigen	Rattus norvegicus	83-88
11811525-8	2001	The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0.	Nitrates	37-44	NBL1, DAN family BMP antagonist	Homo sapiens	46-49
11811525-8	2001	The generation of nitrite (NO2-) and nitrate (NO3-) by the NaN3/catalase/H2O2 system was maximal at pH 5.0.	Nitrates	37-44	catalase	Homo sapiens	64-72
12805808-2	2001	Nitrate (NO3-) concentration in soil solution at the treated site was significantly higher than that of the control in the no-snow period, and it was decreased by dilution from melting snow.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
12805811-2	2001	These high rates of deposition have translated into consistently high levels of nitrate (NO3-) in some streams of the San Bernardino Mountains.	Nitrates	80-87	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
12805813-8	2001	The ratio of mean monthly headwater nitrate (NO3-) concentration to precipitation NO3- concentration declined with increased precipitation concentration.	Nitrates	36-43	NBL1, DAN family BMP antagonist	Homo sapiens	45-48
12805837-2	2001	This leads to a series of environmental impacts, including: (1) nitrate (NO3) contamination of drinking water, (2) eutrophication of freshwater lakes, (3) acidification and biodiversity impacts on terrestrial ecosystems, (4) ozone and particle formation affecting human health, and (5) global climate change induced by emissions of N2O.	Nitrates	64-71	NBL1, DAN family BMP antagonist	Homo sapiens	73-76
11700425-6	2001	In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively.	Nitrates	56-63	TNF receptor superfamily member 1A	Homo sapiens	83-89
12805781-1	2001	Studies with established turf and golf courses have indicated minimal risk of nitrate pollution of groundwater resulting from turfgrass management, but soil nitrate flux in turfgrass sod production farms and golf courses has received less attention.	Nitrates	157-164	superoxide dismutase 1	Homo sapiens	183-186
12805781-2	2001	Information about nitrate-N flux at a particular location can be helpful to the sod producer or the golf course manager when efficiently applying N fertilizers and minimizing risk of nitrate pollution.	Nitrates	18-25	superoxide dismutase 1	Homo sapiens	80-83
11700425-6	2001	In addition, we found a significant correlation between nitrate/nitrite levels and TNF-R1 (r =.70; p =.0001) or TNF-R2 (r =.62; p =.0013), respectively.	Nitrates	56-63	TNF receptor superfamily member 1B	Homo sapiens	112-118
11690645-6	2001	Maximal expression of a nirK-lacZ fusion in strain USDA110 required simultaneously both low level oxygen conditions and the presence of nitrate.	Nitrates	136-143	nitrite reductase, copper-containing	Bradyrhizobium diazoefficiens USDA 110	24-28
11568845-14	2001	Sulfates (SO4) and nitrates (NO3) are found in the area in low concentrations, even below the WHO standards for drinking water, but are significantly higher in the surface water compared to the groundwater.	Nitrates	19-27	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
11583718-12	2001	The increase in the serum level of nitrite/nitrate after 3 months of estrogen therapy showed a significant inverse correlation (r=0.52, P&lt;0.01) with the reduction in the plasma level of ACE activity.	Nitrates	43-50	angiotensin I converting enzyme	Homo sapiens	189-192
11642005-3	2001	TNF alpha was measured by cytotoxicity on L-929 cells and nitrite by the Griess reaction, after reduction of all nitrates to nitrites by nitrate reductase, 1 h after LPS injection (0.5 mg/kg i.p.)	Nitrates	113-121	tumor necrosis factor	Mus musculus	0-9
11534936-8	2001	RESULTS: In the acute phase of colitis, intracolonic nitrite/nitrate levels were significantly higher in the 100 and 500 mg supplemented L-Arg groups than in D-Arg group.	Nitrates	61-68	Rho guanine nucleotide exchange factor 12	Rattus norvegicus	137-142
11641309-10	2001	Among the antihypertensive agents, nitrates, NO donors, and drugs that interfere with the renin-angiotensin-aldosterone system may offer useful tools to lower pulse pressure, in addition to mean blood pressure.	Nitrates	35-43	renin	Homo sapiens	90-95
12060296-6	2001	The NiR gene is expressed in roots and leaves, although the level of expression is much higher in roots, in accordance with the fact that L. japonicus assimilates nitrate mainly in roots.	Nitrates	163-170	nir	Lotus japonicus	4-7
12060296-7	2001	NiR mRNA, protein and activity are induced by nitrate in roots and leaves, while ammonium-grown plants only showed basal levels.	Nitrates	46-53	nir	Lotus japonicus	0-3
11552025-2	2001	The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p &lt; 0.001), whereas the concentrations in plasma were similar.	Nitrates	24-31	colony stimulating factor 2	Homo sapiens	41-44
11602386-1	2001	Nitrite (NO2-) and nitrate (NO3-) concentrations are usually measured as a marker of NO metabolism.	Nitrates	19-26	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
11517313-4	2001	We find that, at biologically relevant O(2) concentrations, HMP preferentially binds NO (not O(2)), which it then reacts with oxygen to form nitrate (in essence NO(-) + O(2) --&gt; NO(3)(-)).	Nitrates	141-148	inner membrane mitochondrial protein	Homo sapiens	60-63
11553762-7	2001	Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase.	Nitrates	56-63	ferredoxin--nitrite reductase, chloroplastic	Solanum lycopersicum	120-137
11553762-7	2001	Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase.	Nitrates	56-63	transaldolase	Solanum lycopersicum	169-182
11553762-7	2001	Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase.	Nitrates	56-63	malate dehydrogenase	Solanum lycopersicum	199-219
11553762-7	2001	Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase.	Nitrates	56-63	asparagine synthetase	Solanum lycopersicum	221-242
11580101-3	2001	Aminoguanidine, a selective inducible NO synthase inhibitor, abolished the inhibition of neutrophil migration and the increase in serum nitrate levels induced by a nonlethal dose of LPS.	Nitrates	136-143	nitric oxide synthase 2, inducible	Mus musculus	28-49
11479842-7	2001	The low levels of LMVEC iNOS expression are associated with a 4-fold lower nitrite and nitrate production.	Nitrates	87-94	nitric oxide synthase 2	Homo sapiens	24-28
11487691-1	2001	The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs.	Nitrates	65-72	nitrate transporter 1.1	Arabidopsis thaliana	4-12
11487691-1	2001	The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs.	Nitrates	65-72	nitrate transporter 1.1	Arabidopsis thaliana	14-18
11487691-1	2001	The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs.	Nitrates	189-196	nitrate transporter 1.1	Arabidopsis thaliana	4-12
11530952-2	2001	The eventual fate of NO is oxidation to nitrite (NO2) and nitrate (NO3), both of which are end-products of NO metabolism.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
11487691-1	2001	The AtNRT1.1 (CHL1) transporter provides a primary mechanism for nitrate uptake in Arabidopsis and is expected to localize to the epidermis and cortex of the mature root, where the bulk of nitrate uptake occurs.	Nitrates	189-196	nitrate transporter 1.1	Arabidopsis thaliana	14-18
11421931-3	2001	The purpose of the study was to examine serum nitrate (NO3) levels in relation to the disease severity in children with AD.	Nitrates	46-53	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
11459488-1	2001	A detailed investigation of the spin-lattice relaxation time, T1, for 207Pb in solid lead nitrate has been undertaken in an effort to understand the mechanism of relaxation.	Nitrates	90-97	spindlin 1	Homo sapiens	32-36
11442316-2	2001	A severe inflammatory response characterized by peritoneal exudation, high peritoneal levels of nitrate/nitrite, and leukocyte infiltration into peritoneal exudate was induced by zymosan administration in iNOS +/+ mice.	Nitrates	96-103	nitric oxide synthase 2, inducible	Mus musculus	205-209
11425809-5	2001	Significantly lower concentrations of plasma nitrate (P &lt; 0.01) were measured at the end of gonadotrophin-releasing hormone (GnRH) down-regulation (24.6 micromol/l +/- 1.4) compared with the concentrations found at day 8 of follicle-stimulating hormone (FSH) stimulation (34.9 micromol/l +/- 2.6) and at the day of human chorionic gonadotrophin (HCG) (35.6 micromol/l +/- 3.3).	Nitrates	45-52	chorionic gonadotropin subunit beta 5	Homo sapiens	324-353
11442316-5	2001	Peritoneal administration of zymosan in the iNOS +/+ mice induced also a significant increase in the plasma levels of nitrite/nitrate and in the levels of peroxynitrite at 18 h after zymosan challenge.	Nitrates	126-133	nitric oxide synthase 2, inducible	Mus musculus	44-48
11407704-8	2001	RESULTS: In iNOS+/+ animals with AIA, the plasma concentration of nitrite/nitrate was increased 3-fold and iNOS expression was detected in cells of the joint.	Nitrates	74-81	nitric oxide synthase 2, inducible	Mus musculus	12-16
11384769-6	2001	Furthermore, the administration of apelin-12 (10 nmol/kg) in rats produced a transitory elevation of the plasma nitrite/nitrate concentration from a basal level of 21.4+/-1.6 to 27.0+/-1.5 microM.	Nitrates	120-127	apelin	Rattus norvegicus	35-41
11556575-1	2001	Nitrate levels in CSF and sera from 16 coma and 19 noncoma falciparum malaria patients were determined using nitric oxide colorometric assay.	Nitrates	0-7	colony stimulating factor 2	Homo sapiens	18-21
11440734-9	2001	Correlation analysis revealed significant inverse correlation between nitrate levels and VEGF.	Nitrates	70-77	vascular endothelial growth factor A	Homo sapiens	89-93
11556575-3	2001	The medians of nitrate level in CSF of coma and noncoma cases were 0.09 (0.01, 0.28) and 0.15 (0, 1.18) microM, respectively.	Nitrates	15-22	colony stimulating factor 2	Homo sapiens	32-35
11337842-1	2001	Water quality associated with nitrate (NO3-) leaching from agricultural soils is an important environmental issue.	Nitrates	30-37	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
11402201-1	2001	Transgenic plants of Arabidopsis bearing the spinach (Spinacia oleracea) nitrite reductase (NiR, EC 1.7.7.1) gene that catalyzes the six-electron reduction of nitrite to ammonium in the second step of the nitrate assimilation pathway were produced by use of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator.	Nitrates	205-212	nitrite reductase 1	Arabidopsis thaliana	73-90
11402201-1	2001	Transgenic plants of Arabidopsis bearing the spinach (Spinacia oleracea) nitrite reductase (NiR, EC 1.7.7.1) gene that catalyzes the six-electron reduction of nitrite to ammonium in the second step of the nitrate assimilation pathway were produced by use of the cauliflower mosaic virus 35S promoter and nopaline synthase terminator.	Nitrates	205-212	nitrite reductase 1	Arabidopsis thaliana	92-95
11432445-1	2001	Plasma nitrite (NO2-) and nitrate (NO3-) are the stable end-products of endogenous nitric oxide (NO) metabolism.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	35-38
11259452-7	2001	However, BRE expression was downregulated in human adrenal adenoma and pheochromocytoma, whereas its expression was enhanced in abnormal adrenal tissues of rats chronically treated with nitrate or nitrite.	Nitrates	186-193	BRISC and BRCA1 A complex member 2	Homo sapiens	9-12
11394308-0	2001	An integrated relay/nitrate reductase field-effect transistor for the sensing of nitrate (NO3-).	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	90-93
11394308-7	2001	The devices that include the bipyridinium units tethered to the gate interface with methylene chain length, -(CH2)n, where n &gt; or = 7, reveal a detection limit of 7 x 10(-5) M for nitrate and a sensitivity of 52 +/- 2 mV dec-1.	Nitrates	183-190	deleted in esophageal cancer 1	Homo sapiens	224-229
11411856-5	2001	Nitrate concentration in the greenhouse effluent can be reduced to acceptable levels for the protection of freshwater aquatic life (i.e., less then 40 ppm) using a loading rate of 1.65 g NO3-N/m2/day and a design water depth of 30 cm or greater.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	187-190
11351772-1	2001	As a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra) is safe and effective in men with erectile dysfunction (ED) of diverse aetiologies, including patients with common cardiovascular diseases who are not receiving organic nitrates or nitrate donor drugs.	Nitrates	304-312	phosphodiesterase 5A	Homo sapiens	100-104
11351772-1	2001	As a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra) is safe and effective in men with erectile dysfunction (ED) of diverse aetiologies, including patients with common cardiovascular diseases who are not receiving organic nitrates or nitrate donor drugs.	Nitrates	304-311	phosphodiesterase 5A	Homo sapiens	100-104
11240977-1	2001	OBJECTIVE: An enhanced circulatory angiotensin II level that results from the administration of nitroglycerin may contribute to the development of nitrate tolerance.	Nitrates	147-154	angiotensinogen	Homo sapiens	35-49
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Nitrates	56-63	toll-like receptor 4	Mus musculus	15-18
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Nitrates	157-164	toll-like receptor 4	Mus musculus	123-126
11292369-4	2001	Treatment with LPS, on its own, increased serum nitrite/nitrate levels at 5 and 20 h after injection, while treatment with LPS and arginine produced nitrite/nitrate levels in the serum even greater at 5 h, but significantly lower at 20 h. Liver iNOS mRNA levels were markedly increased by LPS, and this effect was significantly decreased when mice were also given exogenous arginine.	Nitrates	157-164	toll-like receptor 4	Mus musculus	123-126
11258960-9	2001	This result indicates that, as confirmed from protein analysis after reacting the proteins with NO* for 10 times, when peroxynitrite is coordinated to the heme of myoglobin or hemoglobin it rapidly isomerizes to nitrate without nitrating the globins in physiologically significant amounts.	Nitrates	212-219	myoglobin	Homo sapiens	163-172
11222615-0	2001	snr-1 gene is required for nitrate reduction in Pseudomonas aeruginosa PAO1.	Nitrates	27-34	cytochrome C Snr1	Pseudomonas aeruginosa PAO1	0-5
11288970-0	2001	Dobutamine as bridge to angiotensin-converting enzyme inhibitor-nitrate therapy in endstage heart failure.	Nitrates	64-71	angiotensin I converting enzyme	Homo sapiens	24-53
11288970-12	2001	CONCLUSIONS: Of the patients on dobutamine inotropic support, 70% were successfully transitioned to ACE inhibitor-nitrate therapy, with improved symptoms and LVEF, and with reduced hospitalizations and follow-up dobutamine or transplant.	Nitrates	114-121	angiotensin I converting enzyme	Homo sapiens	100-103
11222615-6	2001	An isogenic snr-1::Gm insertional mutant was unable to grow aerobically with nitrate as a sole nitrogen source or anaerobically with nitrate as an electron acceptor.	Nitrates	133-140	cytochrome C Snr1	Pseudomonas aeruginosa PAO1	12-17
11222615-6	2001	An isogenic snr-1::Gm insertional mutant was unable to grow aerobically with nitrate as a sole nitrogen source or anaerobically with nitrate as an electron acceptor.	Nitrates	77-84	cytochrome C Snr1	Pseudomonas aeruginosa PAO1	12-17
11244107-9	2001	Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize.	Nitrates	81-88	nitrate reductase [NADH] 1	Zea mays	194-196
11244107-9	2001	Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize.	Nitrates	142-149	nitrate reductase [NADH] 1	Zea mays	64-66
11244107-9	2001	Because at this locus coincidences of QTLs for grain yield, GS, NR activity, and nitrate content were also observed, we hypothesize that leaf nitrate accumulation and the reactions catalyzed by NR and GS are coregulated and represent key elements controlling nitrogen use efficiency in maize.	Nitrates	142-149	nitrate reductase [NADH] 1	Zea mays	194-196
11289303-2	2001	For assimilation of nitrate (and nitrite) there are two types of uptake system known: ABC transporters that are driven by ATP hydrolysis, and secondary transporters reliant on a proton motive force.	Nitrates	20-27	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	86-89
11165253-0	2001	An arabidopsis T-DNA mutant affected in Nrt2 genes is impaired in nitrate uptake.	Nitrates	66-73	nitrate transporter 2:1	Arabidopsis thaliana	40-44
11165253-1	2001	Expression analyses of Nrt2 plant genes have shown a strict correlation with root nitrate influx mediated by the high-affinity transport system (HATS).	Nitrates	82-89	nitrate transporter 2:1	Arabidopsis thaliana	23-27
11165253-5	2001	Moreover, the de-regulated expression of a Nicotiana plumbaginifolia Nrt2 gene restored the mutant nitrate influx to that of the wild-type.	Nitrates	99-106	nitrate transporter 2:1	Arabidopsis thaliana	69-73
11351735-6	2001	From the sum of the contributions of particles on the Teflon and nylon filters of the PMDS, nitrate formation almost completely accounts for chloride depletion in PM2.5 prior to collection since the equivalent ratio of [Na+] to ([NO3-] + [Cl-]) is close to the seawater ratio of 0.85.	Nitrates	92-99	NBL1, DAN family BMP antagonist	Homo sapiens	230-233
11165878-6	2001	The concentrations of RSNOs, nitrate, and nitrated LDL were positively correlated to those of total cholesterol, LDL cholesterol, and apoB.	Nitrates	29-36	apolipoprotein B	Homo sapiens	134-138
11227283-10	2001	Nitrate and DON displayed contrasting seasonal trends; NO3 concentrations were larger in the winter while DON concentrations were larger in the summer.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
11208643-1	2001	Levels of nitrite (NO2-) and nitrate (NO3-) were measured in pulmonary edema fluid and plasma from 34 patients with early acute lung injury (ALI) and 20 patients with hydrostatic pulmonary edema.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
11550504-1	2001	The end products of nitric oxide (NO) metabolism in human organism, i.e. anions, nitrites (NO2) and nitrates (NO3), are excreted predominantly (95%) via urine.	Nitrates	100-108	NBL1, DAN family BMP antagonist	Homo sapiens	110-113
11450112-7	2001	Evidence is emerging that Nap fulfills a novel role in nitrate scavenging by some pathogenic bacteria.	Nitrates	55-62	catenin beta like 1	Homo sapiens	26-29
11237288-5	2001	More than 94% of the N2O was from the reduction of NO3-, probably due to aerobic nitrate respiration as well as respiratory denitrification.	Nitrates	81-88	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
11201500-2	2001	Recently, 3-(5"-hydroxymethyl-2"-furyl)-1-benzylindazole (YC-1) was shown to potentiate vascular smooth muscle responsiveness to glyceryl trinitrate (GTN), sodium nitroprusside, and the nitric oxide donor NOC 18, in organic nitrate-naive vascular smooth muscle.	Nitrates	141-148	RNA binding motif single stranded interacting protein 1	Homo sapiens	58-62
11201500-3	2001	We used GTN-tolerant rabbit aortic rings (RARs) to test the hypothesis that a non-vasorelaxant concentration of YC-1 enhances the ability of the prototypical organic nitrate GTN to relax vascular smooth muscle and elevate intravascular cGMP under conditions of GTN tolerance.	Nitrates	166-173	RNA binding motif single stranded interacting protein 1	Homo sapiens	112-116
11215662-3	2001	This investigation studied the attenuation of nitrate (NO3- -N) as wastewater effluent flowed through the shallow ground water of a forested headwater riparian zone within the Appalachian Valley and Ridge physiographic province.	Nitrates	46-53	NBL1, DAN family BMP antagonist	Homo sapiens	55-58
11688686-5	2001	The results showed that redox processes with nitrate, manganese oxide and ferric iron as the electron acceptors exhibited hydrogen threshold values close to PCE/TCE dechlorination, whereas cis-DCE and VC dechlorinations exhibited hydrogen threshold values in the range of sulfate reduction and methanogenesis, respectively.	Nitrates	45-52	24-dehydrocholesterol reductase	Homo sapiens	193-196
11216852-1	2001	Nitrate reductase (NR; EC 1.6.6.1) is the first enzyme of the nitrate-assimilatory pathway and is regulated transcriptionally and post-translationally by several metabolic and environmental signals.	Nitrates	62-69	nitrate reductase [NADH]-like	Cucumis sativus	0-17
11216852-1	2001	Nitrate reductase (NR; EC 1.6.6.1) is the first enzyme of the nitrate-assimilatory pathway and is regulated transcriptionally and post-translationally by several metabolic and environmental signals.	Nitrates	62-69	nitrate reductase [NADH]-like	Cucumis sativus	19-21
11216852-9	2001	It is concluded that, in cucumber plants, the rate of CO2 assimilation controls the rate of nitrate assimilation by modulation of NR expression and activity, and that sugars are presumably involved as regulatory metabolites.	Nitrates	92-99	nitrate reductase [NADH]-like	Cucumis sativus	130-132
11881452-0	2001	[Effects of hyperbaric oxygenation and ceruloplasmin on redox processes and phosphorylation associated with them in the salivary glands in chronic nitrate intoxication].	Nitrates	147-154	ceruloplasmin	Homo sapiens	39-52
11587558-8	2001	The increases paralleled the increases in ALT levels with peak levels of serum nitrate plus nitrite at 6 h (168 +/- 27 microM).	Nitrates	79-86	glutamic pyruvic transaminase, soluble	Mus musculus	42-45
11957779-6	2001	In 1986 WHO fixed the limit of the contents of nitrates in drinking water to 10 mg N-NO3-/dm3 (45 mg NO3-/dm3).	Nitrates	47-55	NBL1, DAN family BMP antagonist	Homo sapiens	85-88
11957779-6	2001	In 1986 WHO fixed the limit of the contents of nitrates in drinking water to 10 mg N-NO3-/dm3 (45 mg NO3-/dm3).	Nitrates	47-55	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	31-38	phenylalanine hydroxylase	Homo sapiens	0-3
11756889-7	2001	Nitrate (NO3) was 49.8 +/- 5.0 micromol/L in patients with PDR and 24.2 +/- 2.8 micromol/L in patients with macula hole; it was also significantly elevated in patients with PDR (P = 0.004, Mann-Whitney), whereas nitrite (NO2) was not detected in this study.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	31-38	phenylalanine hydroxylase	Homo sapiens	120-123
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	92-99	phenylalanine hydroxylase	Homo sapiens	0-3
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	92-99	phenylalanine hydroxylase	Homo sapiens	120-123
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	92-99	phenylalanine hydroxylase	Homo sapiens	0-3
11257884-7	2001	PAH biodegradation ceased when nitrate was depleted and resumed when the enrichment was fed nitrate, demonstrating that PAH biodegradation was dependent upon nitrate reduction.	Nitrates	92-99	phenylalanine hydroxylase	Homo sapiens	120-123
11257884-13	2001	PAH degradation was approximately stoichiometric with the amount of nitrate consumed.	Nitrates	68-75	phenylalanine hydroxylase	Homo sapiens	0-3
11257889-12	2001	The procedure uses the second derivative of the absorption spectrum for nitrate (NO3-), which has a peak at approximately 224 nm that is proportional to the NO3- concentration.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
11257889-12	2001	The procedure uses the second derivative of the absorption spectrum for nitrate (NO3-), which has a peak at approximately 224 nm that is proportional to the NO3- concentration.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	157-160
11137498-7	2000	Because PDE5 is also present in small amounts in the systemic vasculature, sildenafil can cause a synergistic and major decrease in pressure when combined with organic nitrates.	Nitrates	168-176	phosphodiesterase 5A	Homo sapiens	8-12
11116119-4	2000	In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis.	Nitrates	200-207	nitric oxide synthase 3	Rattus norvegicus	9-13
11116119-4	2000	In the AdeNOS-treated rats, the local expression of eNOS in the NTS was confirmed by immunohistochemical staining and Western blot analysis for the eNOS protein and by increased production of nitrite/nitrate in the NTS measured by in vivo microdialysis.	Nitrates	200-207	nitric oxide synthase 3	Rattus norvegicus	52-56
11221914-2	2000	The present study was undertaken to determine whether plasma levels of the NO metabolites nitrate (NO3-) and nitrite (NO2-) in the systemic and cavernous blood of male subjects change during different penile conditions, and whether there is a difference in the NO3- and NO2- levels of normal males and patients with erectile dysfunction (ED).	Nitrates	90-97	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
11098975-13	2000	iNOS+/+ mice subjected to SMAO had increased plasma concentrations of nitrite (NO2-) and nitrate (NO3-), and the plasma concentrations of NO2- and NO3- were highest in the mice in which bacterial translocation had occurred.	Nitrates	89-96	nitric oxide synthase 2, inducible	Mus musculus	0-4
11052959-5	2000	NOS2 activation was estimated by mRNA (RT-PCR) and protein (Western-blot) expression and plasma nitrate/nitrite accumulation.	Nitrates	96-103	nitric oxide synthase 2	Rattus norvegicus	0-4
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	Nitrates	8-15	interleukin 1 beta	Rattus norvegicus	47-69
11063722-6	2000	The functional importance of the diminished eNOS expression was revealed by the finding that serum nitrite/nitrate levels among individuals carrying the -786T--&gt;C mutation were significantly lower than among those without the mutation.	Nitrates	107-114	nitric oxide synthase 3	Homo sapiens	44-48
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	Nitrates	8-15	tumor necrosis factor	Rattus norvegicus	73-106
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	Nitrates	8-15	mitogen activated protein kinase 3	Rattus norvegicus	192-195
11131279-5	2000	Nitrite/nitrate (NOx) production stimulated by interleukin (IL)-1beta or tumor necrosis factor (TNF)-alpha in VSMCs was markedly suppressed by inhibiting MAP kinase by pretreatment with a p42/p44 MAP kinase kinase (MAPKK)-1 inhibitor (PD98059) or by transfecting the dominant-interfering form of the nonphosphorylated MAPKK-1 expressing construct (MAPKK S222A).	Nitrates	8-15	mitogen activated protein kinase kinase 1	Rattus norvegicus	318-325
11046058-5	2000	Incubating LPS-primed monocytes with NCX-4016 resulted in intracellular NO formation as assessed by measuring nitrite/nitrate, intracellular cGMP concentration, and intracellular NO formation.	Nitrates	118-125	T cell leukemia homeobox 2	Homo sapiens	37-40
10986217-2	2000	We have previously shown that protection against D-galactosamine (D-GalN) induced liver injury by prostaglandin E(1) (PGE(1)) was accompanied by an increase in TNF-alpha and nitrite/nitrate in serum.	Nitrates	182-189	galanin and GMAP prepropeptide	Rattus norvegicus	68-72
11001767-5	2000	Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold.	Nitrates	59-66	angiotensinogen	Homo sapiens	0-14
11001767-5	2000	Angiotensin II (ANG II, 100 nM) increased EC production of nitrate/nitrite by 2.4-fold.	Nitrates	59-66	angiotensinogen	Homo sapiens	16-22
11026644-7	2000	N(G)-nitro-L-arginine methyl ester (L-NAME) lowered the basal concentration of plasma nitrate, abolished the increase in plasma nitrate elicited by angiotensin II and norepinephrine, and potentiated the pressor effect of the low dose of angiotensin II, although this dose did not increase NO production.	Nitrates	128-135	angiotensinogen	Homo sapiens	148-162
11026644-2	2000	This study intended to determine first, whether NO-derived plasma nitrate varies in response to increases in blood pressure induced by different mechanical and pharmacologic stimuli, including angiotensin II and catecholamines; and second, specifically to study the interaction between angiotensin II and NO production.	Nitrates	66-73	angiotensinogen	Homo sapiens	193-207
11028657-6	2000	Oxymetazoline and xylometazoline were shown to have a dose dependent inhibitory effect on total iNOS activity indicated by nitrite/nitrate formation in the Griess assay.	Nitrates	131-138	nitric oxide synthase 2	Rattus norvegicus	96-100
11026644-6	2000	The intermediate and high dose, but not the low dose, of angiotensin II increased plasma nitrate concentration.	Nitrates	89-96	angiotensinogen	Homo sapiens	57-71
11022123-8	2000	Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p &lt; 0.05), nitrate and sTNFr-I (p &lt; 0.05), nitrate and sTNFr-II (p &lt; 0.05), and between IL-6 and IL-10 (p &lt; 0.05), respectively.	Nitrates	61-68	interleukin 6	Homo sapiens	73-77
11022123-8	2000	Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p &lt; 0.05), nitrate and sTNFr-I (p &lt; 0.05), nitrate and sTNFr-II (p &lt; 0.05), and between IL-6 and IL-10 (p &lt; 0.05), respectively.	Nitrates	61-68	interleukin 6	Homo sapiens	189-193
11022123-8	2000	Moreover, there were highly significant correlations between nitrate and IL-6 serum levels (p &lt; 0.05), nitrate and sTNFr-I (p &lt; 0.05), nitrate and sTNFr-II (p &lt; 0.05), and between IL-6 and IL-10 (p &lt; 0.05), respectively.	Nitrates	61-68	interleukin 10	Homo sapiens	198-203
10954746-5	2000	A strong correlation between methemoglobin and plasma nitrate formation was observed, suggesting that NO metabolism is a primary physiological cause of hemoglobin oxidation.	Nitrates	54-61	hemoglobin subunit gamma 2	Homo sapiens	29-42
10936493-8	2000	Increase of nitrite and nitrate (as an index of NO formation) in the hippocampus, as observed after ischemia, was reduced in animals treated with recombinant human erythropoietin.	Nitrates	24-31	erythropoietin	Homo sapiens	164-178
10983841-13	2000	These findings suggest that increased production of nitrate in PE may contribute to homeostatic vasodilation against vasoconstriction caused by a higher ET-1 concentration.	Nitrates	52-59	endothelin 1	Homo sapiens	153-157
10983841-0	2000	The relationship between serum nitrate and endothelin-1 concentrations in preeclampsia.	Nitrates	31-38	endothelin 1	Homo sapiens	43-55
10948265-3	2000	Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated.	Nitrates	18-25	nitrate reductase 1	Arabidopsis thaliana	68-85
10983841-8	2000	There was a significant correlation between NOx (nitrite + nitrate) and ET-1 in sera from all 44 women (NP, NTP and PE groups) (p&lt;0.001).	Nitrates	59-66	endothelin 1	Homo sapiens	72-76
10983841-11	2000	However, there was a significant correlation between nitrate and ET-1 in sera from the PE group (p&lt;0.05).	Nitrates	53-60	endothelin 1	Homo sapiens	65-69
10948265-3	2000	Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated.	Nitrates	18-25	nitrate transporter 1.1	Arabidopsis thaliana	111-115
10948265-3	2000	Most of the known nitrate-regulated genes (including those encoding nitrate reductase, the nitrate transporter NRT1, and glutamate synthase) appeared in the 40 most strongly nitrate-induced genes/clones on at least one of the microarrays of the 5524 genes/clones investigated.	Nitrates	18-25	glutamate synthase 1	Arabidopsis thaliana	121-139
10948265-4	2000	Novel nitrate-induced genes were also found, including those encoding (1) possible regulatory proteins, including an MYB transcription factor, a calcium antiporter, and putative protein kinases; (2) metabolic enzymes, including transaldolase and transketolase of the nonoxidative pentose pathway, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase; and (3) proteins with unknown functions, including nonsymbiotic hemoglobin, a senescence-associated protein, and two methyltransferases.	Nitrates	6-13	malate dehydrogenase	Arabidopsis thaliana	297-317
10948265-7	2000	Two genes, AMT1;1 encoding an ammonium transporter and ANR1 encoding a MADS-box factor, were repressed by nitrate.	Nitrates	106-113	anthranilate synthase alpha subunit 1	Arabidopsis thaliana	11-15
10916096-10	2000	Kallikrein gene delivery significantly decreased total urinary protein and albumin excretion and increased levels of urinary kinin, nitrite/nitrate, and cGMP levels.	Nitrates	140-147	kallikrein related peptidase 4	Homo sapiens	0-10
10948265-7	2000	Two genes, AMT1;1 encoding an ammonium transporter and ANR1 encoding a MADS-box factor, were repressed by nitrate.	Nitrates	106-113	AGAMOUS-like 44	Arabidopsis thaliana	55-59
10814817-3	2000	In order to identify cis-acting DNA-elements involved in light and nitrate induction of the birch NiR gene, a 0.9 kb 5" flanking region of the NiR gene was isolated, analysed on the DNA level, and the transcription start site was determined.	Nitrates	67-74	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	98-101
10909895-5	2000	In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline.	Nitrates	88-95	nitric oxide synthase 2	Rattus norvegicus	100-121
10909895-5	2000	In addition, an overproduction of nitric oxide (NO, examined by its metabolites nitrite/nitrate) by inducible NO synthase (iNOS, examined by western blot analysis) is attenuated by pretreatment of LPS rats with terbutaline.	Nitrates	88-95	nitric oxide synthase 2	Rattus norvegicus	123-127
10814817-4	2000	Deletion analysis of the birch NiR promoter region fused to the GUS reporter gene (uidA) in transgenic tobacco (Nicotiana tabacum) revealed the presence of light- and nitrate-responsive promoter fragments.	Nitrates	167-174	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	31-34
10887287-1	2000	The interaction of organic nitrates (nitroethyleneglycol, dinitroglycerol, and their esters with arachidonic acid) with oxyhemoglobin and methemoglobin has been studied.	Nitrates	27-35	hemoglobin subunit gamma 2	Homo sapiens	138-151
10918945-0	2000	Long-term effect of antihypertensive therapy with calcium antagonist or angiotensin converting enzyme inhibitor on serum nitrite/nitrate levels in human essential hypertension.	Nitrates	129-136	angiotensin I converting enzyme	Homo sapiens	72-101
10981158-5	2000	All classes of antihypertensive drugs reduce pulse pressure by means of lowering peripheral resistance, but certain drugs like nitrates, angiotensin converting enzyme inhibitors, and other drugs affecting the renin-angiotensin system have multiple actions that improve large artery stiffness and early wave reflection and are especially useful in treating ISH in the elderly.	Nitrates	127-135	renin	Homo sapiens	209-214
10840402-0	2000	Markedly elevated nitrate/nitrite levels in the cerebrospinal fluid of children with progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO syndrome).	Nitrates	18-25	coiled-coil domain containing 88A	Homo sapiens	159-163
10807981-9	2000	Indeed, nitrite/nitrate was positive in 70% of AFP-negative HCC patients.	Nitrates	16-23	alpha fetoprotein	Homo sapiens	47-50
10883943-3	2000	This study was to determine the tolerance for high doses of angiotensin-converting enzyme (ACE) inhibitor-nitrates in women versus men and to compare their symptomatic response, exercise tolerance, and ventricular functional improvement over 1 year.	Nitrates	106-114	angiotensin I converting enzyme	Homo sapiens	60-89
10883943-3	2000	This study was to determine the tolerance for high doses of angiotensin-converting enzyme (ACE) inhibitor-nitrates in women versus men and to compare their symptomatic response, exercise tolerance, and ventricular functional improvement over 1 year.	Nitrates	106-114	angiotensin I converting enzyme	Homo sapiens	91-94
10883943-5	2000	For all patients, ACE inhibitor-nitrate therapy was intensified.	Nitrates	32-39	angiotensin I converting enzyme	Homo sapiens	18-21
10883943-14	2000	Thus, both women and men tolerated uptitrated ACE inhibitor-nitrate medical therapy, with comparable reversal of heart failure remodeling.	Nitrates	60-67	angiotensin I converting enzyme	Homo sapiens	46-49
10811574-10	2000	For nitrate levels &gt; 25 mg/L, an increased SIR and an increased IRR of 1.46 were observed; however, this increase was not statistically significant, probably because of the small number of cases (15 of 1,064).	Nitrates	4-11	insulin receptor related receptor	Homo sapiens	67-70
10788454-3	2000	Total nitrate and nitrite production was completely abolished in cells from iNOS-deficient animals compared with control cells.	Nitrates	6-13	nitric oxide synthase 2, inducible	Mus musculus	76-80
10759614-2	2000	The changes in both the population spike amplitude and NO metabolites, nitrite (NO2-) and nitrate (NO3-), in the CA1 region were simultaneously determined before and after tetanic stimulation.	Nitrates	90-97	carbonic anhydrase 1	Rattus norvegicus	113-116
10781002-15	2000	LPS pretreatment increased serum corticosterone levels in both mice, while it increased the serum nitrate/nitrite levels in wild-type but not in iNOS deficient mice.	Nitrates	98-105	toll-like receptor 4	Mus musculus	0-3
10795767-1	2000	We have previously reported that ingestion of vegetables containing high nitrate (NO3-) increases breath nitrous oxide (N2O) concentration, probably due to denitrification.	Nitrates	73-80	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
10807014-5	2000	The continuous infusion of 4-ABH4 efficiently suppressed the enhanced calcium-dependent/independent NO synthase activities induced by endotoxin in lung homogenates and completely suppressed the increase in plasma nitrite + nitrate caused by endotoxin at 5 h, with no significant difference compared with the L- NMMA treatment.	Nitrates	223-230	abhydrolase domain containing 4, N-acyl phospholipase B	Rattus norvegicus	29-33
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Nitrates	51-58	synemin	Homo sapiens	170-173
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Nitrates	51-58	synemin	Homo sapiens	174-177
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Nitrates	51-58	synemin	Homo sapiens	174-177
10790841-3	2000	Protonation at the terminal oxygen atoms in methyl nitrate was less exothermic; the calculated proton affinities were 725, 722, and 712 kJ mol-1 for the formation of the syn-syn, anti-syn, and syn-anti ion rotamers 3a+, 3b+, and 3c+, respectively.	Nitrates	51-58	synemin	Homo sapiens	174-177
10753096-12	2000	Increased production of methemoglobin and free radicals of nitric oxide and oxygen due to nitrate metabolism in the body lead to alveolar damage and mismatching of ventilation and perfusion, which may be the reason for high mortality in children due to RRTI.	Nitrates	90-97	hemoglobin subunit gamma 2	Homo sapiens	24-37
10981145-6	2000	ANG II-induced ROS play a pivotal role in several pathophysiologic situations of vascular and renal cells such as hypertension, endothelial dysfunction, nitrate tolerance, atherosclerosis, and cellular remodeling.	Nitrates	153-160	angiotensinogen	Homo sapiens	0-6
10705297-3	2000	IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite.	Nitrates	137-144	interferon gamma	Mus musculus	0-9
10731606-5	2000	We have also demonstrated that methyl viologen is an ineffective electron donor to Nap: its use leads to an underestimation of the contribution of Nap activity to the rate of nitrate reduction in vivo.	Nitrates	175-182	catenin beta like 1	Homo sapiens	147-150
10705297-3	2000	IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite.	Nitrates	137-144	tumor necrosis factor	Mus musculus	11-20
10705297-3	2000	IFN-gamma, TNF-alpha and IL-10 have been shown to be involved in the regulation of LPS-induced serum levels of the NO-oxidation products nitrate and nitrite.	Nitrates	137-144	interleukin 10	Mus musculus	25-30
10772174-7	2000	The limits of detection for nitrite and nitrate ions are 1 and 10 mg/kg, respectively.	Nitrates	40-47	VPS52 subunit of GARP complex	Homo sapiens	53-65
10671549-4	2000	Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis.	Nitrates	141-148	superoxide dismutase 1	Homo sapiens	62-89
12212263-0	2000	[Derivative-ratio derivative spectrum method for determining nitrate and nitrite radicals (NO3- and NO2-) in environmental water].	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	91-94
12212263-4	2000	The results suggest that this method is better than ratio derivative spectrum method and it can be applied for determining nitrate and nitrite (NO3- and NO2-) in environment water samples.	Nitrates	123-130	NBL1, DAN family BMP antagonist	Homo sapiens	144-147
10671549-4	2000	Cells transfected with either wild type (WT) or mutant (G93A) Cu, Zn-superoxide dismutase (Cu,Zn-SOD) produced comparable amounts of nitrite/nitrate but showed different degree of apoptosis.	Nitrates	141-148	superoxide dismutase 1	Homo sapiens	91-100
10631110-0	2000	Nitric oxide nitrates tyrosine residues of tumor-suppressor p53 protein in MCF-7 cells.	Nitrates	13-21	tumor protein p53	Homo sapiens	60-63
10703687-5	2000	RESULTS: No significant differences between groups were detected at baseline except that patients with higher ACE inhibitor doses were more likely to take nitrates, beta-blockers and amiodarone, received higher furosemide doses and had higher serum gamma-glutamyl transferase levels.	Nitrates	155-163	angiotensin I converting enzyme	Homo sapiens	110-113
10677431-5	2000	Furthermore, contrasting the dual-affinity nitrate transport activity of CHL1, OsNRT1 displayed only low-affinity nitrate transport activity in Xenopus oocytes, with a K(m) value of approximately 9 mM.	Nitrates	43-50	DEAD/H-box helicase 11 L homeolog	Xenopus laevis	73-77
10631110-2	2000	As nitration of tyrosine residues in various proteins has been shown to inhibit their functions, we examined whether NO nitrates tyrosine residues in p53 protein.	Nitrates	120-128	tumor protein p53	Homo sapiens	150-153
10620000-9	2000	CONCLUSION: We conclude that inhibition of glucose-stimulated insulin release by transdermal nitroglycerin without causing hyperglycaemia may serve as a novel component of the antianginal mechanism of action of nitrates.	Nitrates	211-219	insulin	Homo sapiens	62-69
10613864-6	2000	While MR1-CYMA retained menaquinone levels comparable to those of MR-1, it lost the ability to reduce iron(III), manganese(IV), and nitrate and to grow by using fumarate as an electron acceptor.	Nitrates	132-139	cytochrome c	Shewanella oneidensis MR-1	10-14
10642319-4	2000	Nitrate/nitrite production in AdeNOS-transduced ZG cells increased from 0.15+/-0.01 to 0.27+/-0.01 micromol/L after stimulation with 1 nmol/L angiotensin II.	Nitrates	0-7	angiotensinogen	Homo sapiens	142-156
10613864-8	2000	The requirement for CymA in anaerobic electron transport to iron(III), fumarate, nitrate, and manganese(IV) is therefore not dependent on the levels of menaquinone in these cells.	Nitrates	81-88	cytochrome c	Shewanella oneidensis MR-1	20-24
10631272-0	2000	Nitrite reductase mutants as an approach to understanding nitrate assimilation in Chlamydomonas reinhardtii.	Nitrates	58-65	uncharacterized protein	Chlamydomonas reinhardtii	0-17
10631272-4	2000	This finding confirms the previous role proposed for NR on its own regulation (autoregulation) and on the other genes for nitrate assimilation in C. reinhardtii.	Nitrates	122-129	uncharacterized protein	Chlamydomonas reinhardtii	53-55
10627036-7	1999	The ORF 5- and ORF 6-encoded proteins were shown by immunoblotting to be synthesized by cells grown in the presence of nitrate.	Nitrates	119-126	ORF5	Clostridium perfringens	4-9
11247410-4	2000	The theories put forward to explain nitrate tolerance are examined, including recent work on vascular superoxide and endothelin-1 regulation.	Nitrates	36-43	endothelin 1	Homo sapiens	117-129
10689548-6	1999	A significant correlation was shown between TGF-beta, and nitrate levels in all tissues (r = 0.24, P = 0.01), as well as in malignant tissues (r = 0.3, P = 0.026).	Nitrates	58-65	transforming growth factor beta 1	Homo sapiens	44-52
10627036-7	1999	The ORF 5- and ORF 6-encoded proteins were shown by immunoblotting to be synthesized by cells grown in the presence of nitrate.	Nitrates	119-126	ORF6	Clostridium perfringens	15-20
10627036-10	1999	Instead, all 5 ORFs downstream of ORF 6 are homologous to genes reported for molybdopterin biosynthesis, unlike the genomic organization already determined for the respiratory and assimilatory nitrate-reduction systems.	Nitrates	193-200	ORF6	Clostridium perfringens	34-39
10541285-8	1999	Similarly, cilazaprilat elicited greater bradykinin-dependent increases of nitrite/nitrate in the medulla.	Nitrates	83-90	kininogen 1	Canis lupus familiaris	41-51
10583588-2	1999	Continuous treatment with 5 mm or 10 mm l-N6-(1-imino-ethyl)-lysine (L-NIL), a selective NOS2-inhibitor, in acidified drinking water for up to 7 weeks consistently reduced infection-induced nitrate/nitrite to background levels in mycobacteria-infected BALB/c mice.	Nitrates	190-197	nitric oxide synthase 2, inducible	Mus musculus	89-93
10515827-4	1999	In contrast, higher levels of IL-6, IL-10, and MCP-1 in plasma and higher levels of IL-12, interferon (IFN)-gamma, and nitrite/nitrate were found in all compartments of TNF/Lt-alpha-deficient mice.	Nitrates	127-134	tumor necrosis factor	Mus musculus	169-172
10515827-5	1999	These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production.	Nitrates	259-266	tumor necrosis factor	Mus musculus	24-27
10515827-5	1999	These data confirm that TNF or Lt-alpha is a key cytokine for the anticryptococcal response and demonstrate its major role for the induction of IL-1beta, IL-6, and KC in the brain; however, its presence is not a prerequisite for IL-12, IFN-gamma, and nitrite/nitrate production.	Nitrates	259-266	lymphotoxin A	Mus musculus	31-39
10645729-4	1999	ARS levels were very low in cells grown in the presence of NH4Cl and dramatically increased on agar medium deprived of any nitrogen source or containing nitrate, nitrite, urea, arginine or glutamine.	Nitrates	153-160	uncharacterized protein	Chlamydomonas reinhardtii	0-3
10645729-5	1999	Compared to nitrogen-free medium, a slight positive effect of nitrate in the NR+ strain and a significant negative effect of nitrite in both NR+ and NR- strains were observed.	Nitrates	62-69	uncharacterized protein	Chlamydomonas reinhardtii	77-79
10534444-4	1999	A significant decrease in the average postwounding urinary nitrate levels compared to prewounding levels was observed within the TGF-beta1 treatment group animals (P &lt;/= 0.001) with an insignificant change for the phosphate-buffered saline control animals (P &lt;/= 0.10).	Nitrates	59-66	transforming growth factor, beta 1	Mus musculus	129-138
10546136-1	1999	This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator.	Nitrates	178-186	plasminogen activator, tissue type	Homo sapiens	285-318
10546136-1	1999	This case report describes a 48-year-old woman patient with variant angina who died because of severe myocardial ischemia and cardiogenic shock, in spite of chronic therapy with nitrates and calcium-antagonists and acute intravenous administration of nitrates, calcium-antagonists and tissue-type plasminogen activator.	Nitrates	251-259	plasminogen activator, tissue type	Homo sapiens	285-318
10511130-9	1999	Thus long-term ACE inhibition prevents nitrate tolerance by an endothelium-dependent mechanism involving mainly an enhanced NO availability via B2-kinin receptor.	Nitrates	39-46	angiotensin I converting enzyme	Rattus norvegicus	15-18
10490919-7	1999	The survival rate to endotoxin in mice was significantly (P &lt;.01) increased by the presence of higenamine in the LPS-treated group up to 48 h. Serum nitrite/nitrate levels were significantly (P &lt;.05) reduced by higenamine in LPS-treated rats.	Nitrates	160-167	toll-like receptor 4	Mus musculus	116-119
10534444-5	1999	Additionally, TGF-beta1-treated animals showed significant connective tissue repair compared to controls without a concurrent increase in postwounding urinary nitrate levels, supporting the noninflammatory nature of the perforated mesentery model.	Nitrates	159-166	transforming growth factor, beta 1	Mus musculus	14-23
10438436-7	1999	In the DHEA-S group, plasma circulating nitrate and nitrite increased significantly at 10 and 30 min after DHEA-S administration respectively (P &lt; 0.05).	Nitrates	40-47	sulfotransferase family 2A member 1	Homo sapiens	7-13
10512631-1	1999	The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1).	Nitrates	175-182	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	198-206
10512631-1	1999	The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1).	Nitrates	175-182	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	198-206
10512631-1	1999	The effect of anion binding on iodopsin, the chicken red-sensitive cone visual pigment, was studied by measurements of the Fourier transform infrared spectra of chloride- and nitrate-bound forms of iodopsin at 77 K. In addition to the blue shift of the absorption maximum upon substituting nitrate for chloride, the C=C stretching vibrations of iodopsin and its photoproducts were upshifted 5-6 cm(-)(1).	Nitrates	290-297	opsin 1 (cone pigments), long-wave-sensitive (color blindness, protan)	Gallus gallus	31-39
10503839-8	1999	Nitrate levels were positively correlated with blood and 24 h urinary neopterin (e.g. plasma nitrate and blood neopterin: r = 0.54, P&lt;0.0001), and in some cases, to C-reactive protein.	Nitrates	0-7	C-reactive protein	Homo sapiens	168-186
10438436-7	1999	In the DHEA-S group, plasma circulating nitrate and nitrite increased significantly at 10 and 30 min after DHEA-S administration respectively (P &lt; 0.05).	Nitrates	40-47	sulfotransferase family 2A member 1	Homo sapiens	107-113
11776556-2	1999	OBJECTIVE: To evaluate the clinical applications of the detection of the stable end products of NO, nitrite and nitrate (NO2-./NO3-.)	Nitrates	112-119	NBL1, DAN family BMP antagonist	Homo sapiens	127-130
10485617-4	1999	The vascular expression of bNOS as well as that of ecNOS was decreased along with tissue nitrite/nitrate contents in DOCA-salt and 2K1C hypertension.	Nitrates	97-104	nitric oxide synthase 1	Rattus norvegicus	27-31
10485617-5	1999	The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents.	Nitrates	102-109	nitric oxide synthase 1	Rattus norvegicus	23-27
10485617-5	1999	The expression of both bNOS and ecNOS was increased in SHR with concomitant changes of tissue nitrite/nitrate contents.	Nitrates	102-109	nitric oxide synthase 3	Rattus norvegicus	32-37
10449574-1	1999	The Arabidopsis CHL1 (AtNRT1) gene encodes an inducible component of low-affinity nitrate uptake, which necessitates a "two-component" model to account for the constitutive low-affinity uptake observed in physiological studies.	Nitrates	82-89	nitrate transporter 1.1	Arabidopsis thaliana	16-20
10449574-1	1999	The Arabidopsis CHL1 (AtNRT1) gene encodes an inducible component of low-affinity nitrate uptake, which necessitates a "two-component" model to account for the constitutive low-affinity uptake observed in physiological studies.	Nitrates	82-89	nitrate transporter 1.1	Arabidopsis thaliana	22-28
10449574-2	1999	Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake.	Nitrates	188-195	nitrate transporter 1.1	Arabidopsis thaliana	54-58
10449574-2	1999	Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake.	Nitrates	188-195	nitrate transporter 1:2	Arabidopsis thaliana	68-76
10449574-2	1999	Here, we report the cloning and characterization of a CHL1 homolog, AtNRT1:2 (originally named NTL1), with data to indicate that this gene encodes a constitutive component of low-affinity nitrate uptake.	Nitrates	188-195	nitrate transporter 1:2	Arabidopsis thaliana	95-99
10449574-3	1999	Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate.	Nitrates	66-73	nitrate transporter 1.1	Arabidopsis thaliana	39-45
10449574-3	1999	Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate.	Nitrates	110-117	nitrate transporter 1.1	Arabidopsis thaliana	39-45
10449574-3	1999	Transgenic plants expressing antisense AtNRT1:2 exhibited reduced nitrate-induced membrane depolarization and nitrate uptake activities in assays with 10 mM nitrate.	Nitrates	110-117	nitrate transporter 1.1	Arabidopsis thaliana	39-45
10449574-5	1999	Kinetic analysis of AtNRT1:2-injected Xenopus oocytes yielded a K(m) for nitrate of approximately 5.9 mM.	Nitrates	73-80	nitrate transporter 1.1	Arabidopsis thaliana	20-26
10449574-6	1999	In contrast to CHL1, AtNRT1:2 was constitutively expressed before and after nitrate exposure (it was repressed transiently only when the level of CHL1 mRNA started to increase significantly), and its mRNA was found primarily in root hairs and the epidermis in both young (root tips) and mature regions of roots.	Nitrates	76-83	nitrate transporter 1:2	Arabidopsis thaliana	21-29
10398706-0	1999	Simultaneous expression of NAD-dependent isocitrate dehydrogenase and other krebs cycle genes after nitrate resupply to short-term nitrogen-starved tobacco Mitochondrial NAD-dependent (IDH) and cytosolic NADP-dependent isocitrate dehydrogenases have been considered as candidates for the production of 2-oxoglutarate required by the glutamine synthetase/glutamate synthase cycle.	Nitrates	100-107	isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial	Nicotiana tabacum	27-65
10381925-10	1999	Plasma nitrite/nitrate levels and hepatic NOS activity were increased significantly by CCl4 treatment.	Nitrates	15-22	C-C motif chemokine ligand 4	Rattus norvegicus	87-91
10411000-3	1999	Incubation of fMLP-activated neutrophils with OH-L-Arg resulted in a production of nitrite, nitrate, and citrulline that was greater than with unstimulated neutrophils but was not inhibited by the NOS inhibitors L-NMMA and L-NIO or the cytochrome P450 inhibitor troleandomycin and was not seen when OH-L-Arg was replaced with L-Arg.	Nitrates	92-99	formyl peptide receptor 1	Homo sapiens	14-18
10398706-1	1999	The increase in IDH transcripts in leaf and root tissues, induced by nitrate or NH4+ resupply to short-term N-starved tobacco (Nicotiana tabacum) plants, suggested that this enzyme could play such a role.	Nitrates	70-77	isocitrate dehydrogenase [NADP]	Nicotiana tabacum	17-20
10398706-2	1999	The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently.	Nitrates	141-148	citrate synthase, glyoxysomal-like	Nicotiana tabacum	47-63
10398706-2	1999	The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently.	Nitrates	141-148	isocitrate dehydrogenase [NADP]	Nicotiana tabacum	76-79
10398706-2	1999	The leaf and root steady-state mRNA levels of citrate synthase, acotinase, IDH, and glutamine synthetase were found to respond similarly to nitrate, whereas those for cytosolic NADP-dependent isocitrate dehydrogenase and fumarase responded differently.	Nitrates	141-148	glutamine synthetase	Nicotiana tabacum	85-105
10503995-2	1999	NO is rapidly decomposed to nitrite (NO2-) and nitrate (NO3-).	Nitrates	47-54	NBL1, DAN family BMP antagonist	Homo sapiens	56-59
10407321-6	1999	By using this "reaction continuous-flow mass spectrometry" (R/CFMS) we developed methods for the (15)N determination of nitrite and nitrate from tracer experiment samples, i.e. artificially enriched in (15)N. Because both methods are based on the same principle, one continuous flow setup connected directly to a quadrupole mass spectrometer for all determinations was used.	Nitrates	132-139	colony stimulating factor 1 receptor	Homo sapiens	62-66
10377083-0	1999	Evidence for a causal role of the renin-angiotensin system in nitrate tolerance.	Nitrates	62-69	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	34-39
10377083-2	1999	Both phenomena are stimulated by angiotensin II in vitro, and the renin-angiotensin system is activated during early nitrate therapy.	Nitrates	117-124	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	66-71
10377083-3	1999	We hypothesized that either angiotensin II or ET-1 may increase vascular O2.- production during nitrate therapy.	Nitrates	96-103	endothelin-1	Oryctolagus cuniculus	46-50
10377083-14	1999	CONCLUSIONS: The positive effects of AT1 and ET-1 receptor blockade on tolerance and O2.- production imply a pathophysiological role for angiotensin II and to some extent for ET-1 in the development of nitrate tolerance.	Nitrates	202-209	endothelin-1	Oryctolagus cuniculus	45-49
10377083-14	1999	CONCLUSIONS: The positive effects of AT1 and ET-1 receptor blockade on tolerance and O2.- production imply a pathophysiological role for angiotensin II and to some extent for ET-1 in the development of nitrate tolerance.	Nitrates	202-209	endothelin-1	Oryctolagus cuniculus	175-179
10380907-3	1999	We also investigated SP-induced formation of nitrite and nitrate as an index of nitric oxide (NO) production.	Nitrates	57-64	tachykinin precursor 1	Homo sapiens	21-23
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P &lt; 0.05) following a 24-h incubation protocol.	Nitrates	252-259	colony stimulating factor 3	Homo sapiens	35-40
10437653-5	1999	In addition, the co-application of G-CSF resulted in a decreased IFN-gamma/LPS mediated iNOS protein generation as detected by immunoblotting methods after 24 and 48 h. Measurement of the stable NO metabolites showed a significant reduction of nitrite/nitrate concentrations following co-incubation of VSMC with G-CSF + IFN-gamma/LPS (242.57 +/- 10.73 nmol NO2-/NO3-/mg cell protein, n = 8) as compared to IFN-gamma/LPS treatment (306.20 +/- 19.26 nmol NO2-/NO3-/mg cell protein, n = 8, P &lt; 0.05) following a 24-h incubation protocol.	Nitrates	252-259	interferon gamma	Homo sapiens	65-74
10338458-0	1999	Double-blind, placebo-controlled study to evaluate the effect of organic nitrates in patients with chronic heart failure treated with angiotensin-converting enzyme inhibition.	Nitrates	73-81	angiotensin I converting enzyme	Homo sapiens	134-163
10381142-7	1999	Substitution of chloride by gluconate enhanced basal steroid secretion, but nitrate completely abolished the effect of 1 IU/L hCG on androgen secretion, which could be partially overcome by increasing the gonadotropin concentration.	Nitrates	76-83	chorionic gonadotropin subunit beta 5	Homo sapiens	126-129
10338458-10	1999	CONCLUSION: High-dose nitrate therapy significantly improves exercise tolerance and left ventricular size and systolic function in patients with chronic, mild to moderate CHF already treated with ACE inhibitors.	Nitrates	22-29	angiotensin I converting enzyme	Homo sapiens	196-199
10330425-13	1999	12-LO KO macrophages generated 50% less nitrate/nitrite when compared with C57BL/6 macrophages.	Nitrates	40-47	arachidonate 15-lipoxygenase	Mus musculus	0-5
10325247-14	1999	To our knowledge, this is the first demonstration that NO can promote NF-kappaB activation in the heart, a finding that identifies a new biological function of NO and may have important implications for various pathophysiological conditions in which NO is involved and for nitrate therapy.	Nitrates	273-280	nuclear factor kappa B subunit 1	Homo sapiens	70-79
10385249-9	1999	Rh-EPO (25, 50 and 100 U 100 g(-1), 5 min following the onset of reperfusion) increased survival rate (70% at 4 h of reperfusion with the highest dose), reduced plasma nitrite/nitrate concentrations (10.3+/-3.3 microM), increased MAP, did not change RBC count and blood Hb, and inhibited iNOS activity in thoracic aortae.	Nitrates	176-183	erythropoietin	Rattus norvegicus	3-6
10359060-4	1999	LPS (200 microg/ml) significantly increased the production of nitrate within a 10-min incubation period.	Nitrates	62-69	interferon regulatory factor 6	Homo sapiens	0-3
10218970-4	1999	Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively.	Nitrates	94-101	interleukin 1 beta	Rattus norvegicus	5-27
10218970-4	1999	Both interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha potently stimulated nitrite/nitrate (NOx) production with a concomitant expression of iNOS mRNA and protein as demonstrated by Northern and Western blot analysis, respectively.	Nitrates	94-101	tumor necrosis factor	Rattus norvegicus	32-65
10235127-6	1999	This deteriorative action of postadministration of L-arginine (300 mg/kg intraperitoneally) was prevented by pretreatment with aminoguanidine (100 mg/kg subcutaneously), a selective iNOS inhibitor, with inhibition of increases in gastric mucosal iNOS activity and nitrite/nitrate concentration.	Nitrates	272-279	nitric oxide synthase 2	Rattus norvegicus	182-186
10330471-0	1999	CHL1 is a dual-affinity nitrate transporter of Arabidopsis involved in multiple phases of nitrate uptake.	Nitrates	24-31	nitrate transporter 1.1	Arabidopsis thaliana	0-4
10367389-4	1999	The peak interfering with BCAA elutes at the same retention time as nitrate; however, we have not confirmed the presence of nitrate.	Nitrates	68-75	AT-rich interaction domain 4B	Homo sapiens	26-30
10330471-3	1999	Here, we demonstrate that a well-known low-affinity nitrate uptake mutant of Arabidopsis, chl1, is also defective in high-affinity nitrate uptake.	Nitrates	52-59	nitrate transporter 1.1	Arabidopsis thaliana	90-94
10330471-3	1999	Here, we demonstrate that a well-known low-affinity nitrate uptake mutant of Arabidopsis, chl1, is also defective in high-affinity nitrate uptake.	Nitrates	131-138	nitrate transporter 1.1	Arabidopsis thaliana	90-94
10330471-4	1999	Two to 3 hr after nitrate induction, uptake activities of various chl1 mutants at 250 microM nitrate (a high-affinity concentration) were only 18 to 30% of those of wild-type plants.	Nitrates	18-25	nitrate transporter 1.1	Arabidopsis thaliana	66-70
10350003-0	1999	The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.	Nitrates	102-109	MAPK associated protein 1	Homo sapiens	23-28
10330471-4	1999	Two to 3 hr after nitrate induction, uptake activities of various chl1 mutants at 250 microM nitrate (a high-affinity concentration) were only 18 to 30% of those of wild-type plants.	Nitrates	93-100	nitrate transporter 1.1	Arabidopsis thaliana	66-70
10330471-7	1999	Kinetic analysis of nitrate uptake by CHL1-injected Xenopus oocytes displayed a biphasic pattern with a Michaelis-Menten Km value of approximately 50 microM for the high-affinity phase and approximately 4 mM for the low-affinity phase.	Nitrates	20-27	DEAD/H-box helicase 11 L homeolog	Xenopus laevis	38-42
10330471-8	1999	These results indicate that in addition to being a low-affinity nitrate transporter, as previously recognized, CHL1 is also involved in both the inducible and constitutive phases of high-affinity nitrate uptake in Arabidopsis.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	111-115
10208844-6	1999	Treatment of rats with the selective iNOS inhibitor L-iminoethyl-lysine (L-NIL) dramatically reduced NO levels in lavage fluid as measured by decreases in nitrate and nitrite concentrations without significantly affecting iNOS protein levels.	Nitrates	155-162	nitric oxide synthase 2	Rattus norvegicus	37-41
10190728-7	1999	In the overall series, a highly significant linear correlation between nitrites/nitrates and vWF:antigen levels was observed in patients with cirrhosis (r=0.79, p&lt;0.001).	Nitrates	80-88	von Willebrand factor	Homo sapiens	93-96
10037703-3	1999	By using high performance anion-exchange chromatography (HPAEC) with nitrate eluents, we found that lactonization of alpha2,8-linked OSA/PSA (oligo/poly-Neu5Ac, oligo/poly-Neu5Gc and oligo/poly-KDN) proceeds readily, and the lactonization process displays three discrete stages.	Nitrates	69-76	aminopeptidase puromycin sensitive	Homo sapiens	137-140
10190728-4	1999	RESULTS: vWF:antigen and nitrite/nitrate levels were significantly higher in cirrhotic patients (367+/-185% and 29.3+/-10.8 micromol/l) than in healthy subjects (92+/-20% and 19.2+/-8.3 micromol/l, p&lt;0.05, respectively).	Nitrates	33-40	von Willebrand factor	Homo sapiens	9-12
28307406-4	1999	We used this method to examine spatial patterns of soil ammonium (NH+4) and nitrate (NO-3) availability in a mid-successional coastal dune for four periods of time during the growing season.	Nitrates	76-83	NBL1, DAN family BMP antagonist	Homo sapiens	85-89
10190728-5	1999	Higher levels of vWF:antigen and nitrites/nitrates were observed in patients with more advanced degrees of liver failure, as reflected by quantitative Child-Pugh"s score (516+/-154% and 38.3+/-7.8 micromol/l in Child-Pugh &gt; or = 9 vs 227+/-61% and 21.0+/-6.1 micromol/l in Child-Pugh &lt;9, p&lt;0.001, respectively).	Nitrates	42-50	von Willebrand factor	Homo sapiens	17-20
10203321-1	1999	To elucidate the involvement of NO in pain transmission in humans, we measured NO metabolites (nitrite/nitrate) in the CSF of patients with painful diseases using an NO analyzer based on the Griess method.	Nitrates	103-110	colony stimulating factor 2	Homo sapiens	119-122
10205909-1	1999	Putative high-affinity nitrate (NO3-) transporter genes, designated Nrt2;1At and Nrt2;2At, were isolated from Arabidopsis thaliana by RT-PCR using degenerate primers.	Nitrates	23-30	nitrate transporter 2:1	Arabidopsis thaliana	68-72
10205909-1	1999	Putative high-affinity nitrate (NO3-) transporter genes, designated Nrt2;1At and Nrt2;2At, were isolated from Arabidopsis thaliana by RT-PCR using degenerate primers.	Nitrates	23-30	nitrate transporter 2:1	Arabidopsis thaliana	81-85
10205669-6	1999	The products of nitrate reduction i.e., nitrite and ammonium ion had inhibitory and stimulatory effects respectively, on NR transcript accumulation.	Nitrates	16-23	nitrate reductase [NADH] 1	Zea mays	121-123
10063925-6	1999	Adrenomedullin levels had significant correlations with aldosterone (r = 0.55; P &lt; 0.001), plasma renin activity (r = 0.49; P &lt; 0.001) and nitrates-nitrites levels (r = 0.52; P &lt; 0.001).	Nitrates	145-153	adrenomedullin	Homo sapiens	0-14
10205669-0	1999	Roles of nitrate, nitrite and ammonium ion in phytochrome regulation of nitrate reductase gene expression in maize.	Nitrates	9-16	nitrate reductase [NADH] 1	Zea mays	72-89
10205669-1	1999	The influence of nitrate and its metabolites on the nitrate reductase (NR) gene expression and its relationship with phytochrome (Pfr) regulation of NR in etiolated maize leaves is examined.	Nitrates	17-24	nitrate reductase [NADH] 1	Zea mays	52-69
10205669-1	1999	The influence of nitrate and its metabolites on the nitrate reductase (NR) gene expression and its relationship with phytochrome (Pfr) regulation of NR in etiolated maize leaves is examined.	Nitrates	17-24	nitrate reductase [NADH] 1	Zea mays	71-73
9854041-8	1998	Thus, our novel mouse model of chronic eNOS overexpression demonstrates that, in addition to the essential role of eNOS in blood pressure regulation, tonic NO release by eNOS in the endothelium induces the reduced vascular reactivity to NO-mediated vasodilators, providing several insights into the pathogenesis of nitrate tolerance.	Nitrates	315-322	nitric oxide synthase 3, endothelial cell	Mus musculus	39-43
9845803-0	1999	Pharmacokinetics of ITF 296 (Sinitrodil) a novel organic nitrate, in healthy volunteers.	Nitrates	57-64	trefoil factor 3	Homo sapiens	20-23
9845803-1	1999	ITF 296 is a new orally active nitrate acting selectively on large arterial vessels over a wide range of doses.	Nitrates	31-38	trefoil factor 3	Homo sapiens	0-3
10362348-5	1999	Recent studies have shown that the use of nitrates in patients already treated with standard heart failure therapy, including angiotensin converting enzyme (ACE) inhibitors, resulted in hemodynamic improvement, marked enhancement of exercise tolerance, reduction of left ventricular size, and augmentation of systolic function.	Nitrates	42-50	angiotensin I converting enzyme	Homo sapiens	126-155
10362348-5	1999	Recent studies have shown that the use of nitrates in patients already treated with standard heart failure therapy, including angiotensin converting enzyme (ACE) inhibitors, resulted in hemodynamic improvement, marked enhancement of exercise tolerance, reduction of left ventricular size, and augmentation of systolic function.	Nitrates	42-50	angiotensin I converting enzyme	Homo sapiens	157-160
9844028-0	1998	The Arabidopsis CHL1 protein plays a major role in high-affinity nitrate uptake.	Nitrates	65-72	nitrate transporter 1.1	Arabidopsis thaliana	16-20
9844028-8	1998	These results show that CHL1 is an important component of both the high-affinity and the low-affinity nitrate-uptake systems and indicate that CHL1 may be a dual-affinity nitrate transporter.	Nitrates	102-109	nitrate transporter 1.1	Arabidopsis thaliana	24-28
9844028-8	1998	These results show that CHL1 is an important component of both the high-affinity and the low-affinity nitrate-uptake systems and indicate that CHL1 may be a dual-affinity nitrate transporter.	Nitrates	102-109	nitrate transporter 1.1	Arabidopsis thaliana	143-147
9844028-1	1998	The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants.	Nitrates	46-53	nitrate transporter 1.1	Arabidopsis thaliana	4-8
9844028-1	1998	The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants.	Nitrates	46-53	nitrate transporter 1.1	Arabidopsis thaliana	10-14
9844028-1	1998	The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	4-8
9844028-1	1998	The CHL1 (NRT1) gene of Arabidopsis encodes a nitrate-inducible nitrate transporter that is thought to be a component of the low-affinity (mechanism II) nitrate-uptake system in plants.	Nitrates	64-71	nitrate transporter 1.1	Arabidopsis thaliana	10-14
9844028-6	1998	chl1 mutants show reduced membrane depolarization in root epidermal cells in response to low (250 microM) and high (10 mM) concentrations of nitrate.	Nitrates	141-148	nitrate transporter 1.1	Arabidopsis thaliana	0-4
9844028-7	1998	Low levels of nitrate (100 microM) induce a rapid increase in CHL1 mRNA.	Nitrates	14-21	nitrate transporter 1.1	Arabidopsis thaliana	62-66
9821686-11	1998	The negative effect on the nia2 transcript pool exerted by exogeneous glutamine may, therefore, be explained as a result of the down-regulation of nitrate-uptake permeases in the roots by glutamine.	Nitrates	147-154	nitrate reductase 2	Arabidopsis thaliana	27-31
9843849-2	1998	NO can combine with superoxide (O-2) to form peroxynitrite, which can decompose into nitrate.	Nitrates	85-92	immunoglobulin kappa variable 1D-39	Homo sapiens	32-35
9843849-10	1998	These data demonstrate that O-2 released from PMNs can decrease NO by conversion to nitrate and suggest a potential mechanism for modulation of NO levels in vivo.	Nitrates	84-91	immunoglobulin kappa variable 1D-39	Homo sapiens	28-31
9853182-0	1998	The impact of beta-receptor blocker addition to high-dose angiotensin-converting enzyme inhibitor-nitrate therapy in heart failure.	Nitrates	98-105	angiotensin I converting enzyme	Homo sapiens	58-87
9853182-3	1998	Similarly, high doses of angiotensin-converting enzyme (ACE) inhibitors with nitrates partially reverse the ventricular remodeling of heart failure.	Nitrates	77-85	angiotensin I converting enzyme	Homo sapiens	25-54
9853182-3	1998	Similarly, high doses of angiotensin-converting enzyme (ACE) inhibitors with nitrates partially reverse the ventricular remodeling of heart failure.	Nitrates	77-85	angiotensin I converting enzyme	Homo sapiens	56-59
9853182-4	1998	HYPOTHESIS: We tested the hypothesis that beta-blocker therapy added to high-dose ACE inhibitor-nitrates would potentiate the reversal of heart failure.	Nitrates	96-104	angiotensin I converting enzyme	Homo sapiens	82-85
9853182-13	1998	CONCLUSION: High-dose ACE inhibitor-nitrate therapy significantly improved patient clinical status and left ventricular systolic function in heart failure.	Nitrates	36-43	angiotensin I converting enzyme	Homo sapiens	22-25
9794807-0	1998	Clustering of the YNA1 gene encoding a Zn(II)2Cys6 transcriptional factor in the yeast Hansenula polymorpha with the nitrate assimilation genes YNT1, YNI1 and YNR1, and its involvement in their transcriptional activation.	Nitrates	117-124	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	18-22
9794807-0	1998	Clustering of the YNA1 gene encoding a Zn(II)2Cys6 transcriptional factor in the yeast Hansenula polymorpha with the nitrate assimilation genes YNT1, YNI1 and YNR1, and its involvement in their transcriptional activation.	Nitrates	117-124	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	144-148
9794807-2	1998	In addition, DNA sequencing of the region containing these genes demonstrated that a new open reading frame called YNA1 (yeast nitrate assimilation) was located between YNR1 and YNI1.	Nitrates	127-134	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	115-119
9794807-3	1998	The YNA1 gene encodes a protein of 529 residues belonging to the family of Zn(II)2Cys6 fungal transcriptional factors, and has the highest similarity to the transcriptional factors encoded by nirA, and to a smaller extent to nit-4, involved in the nitrate induction of the gene involved in the assimilation of this compound in filamentous fungi.	Nitrates	248-255	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	4-8
9794807-4	1998	Northern blot analysis showed the presence of the YNA1 transcript in cells incubated in nitrate, nitrate plus ammonium, ammonium, and nitrogen-free media, with a decrease in its levels in those cells incubated in ammonium.	Nitrates	88-95	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	50-54
9794807-4	1998	Northern blot analysis showed the presence of the YNA1 transcript in cells incubated in nitrate, nitrate plus ammonium, ammonium, and nitrogen-free media, with a decrease in its levels in those cells incubated in ammonium.	Nitrates	97-104	rRNA (cytosine-C5-)-methyltransferase NOP2	Saccharomyces cerevisiae S288C	50-54
9881153-9	1998	Expression studies at the protein and mRNA levels show that each subunit is present in both root and leaf tissues and that the three IDH genes respond in the same way to nitrate addition.	Nitrates	170-177	isocitrate dehydrogenase [NADP]	Nicotiana tabacum	133-136
9763537-7	1998	045), hypertriglyceridemia (P=0.015), and chronic intake of nitrates (P&lt;0.001) were significantly and positively related to tPA antigen concentration, while the chronic intake of aspirin was inversely related to tPA antigen (P&lt;0.001).	Nitrates	60-68	plasminogen activator, tissue type	Homo sapiens	127-130
9767541-6	1998	Kallikrein gene transfer caused left ventricular mass reduction and elevated glomerular filtration rate, renal blood flow, urinary excretion, urinary kinin, nitrite/nitrate content, cGMP and cAMP levels.	Nitrates	165-172	kallikrein related peptidase 4	Homo sapiens	0-10
9811394-9	1998	There are a few studies assessing NO generation in hypertensive children via plasma nitrite and nitrate, the NO end products, which suggest normal or increased production as opposed to a reduction, perhaps as a compensatory phenomenon.	Nitrates	96-103	nitric oxide synthase 2	Homo sapiens	34-36
9737004-0	1998	Clustering of the nitrite reductase gene and a light-regulated gene with nitrate assimilation loci in Chlamydomonas reinhardtii.	Nitrates	73-80	uncharacterized protein	Chlamydomonas reinhardtii	18-35
9788654-10	1998	Nitrate+nitrite levels returned to normal within 24 h. CRP generation increased during 12 h following trauma and was most marked in severest trauma (ISS &gt;50).	Nitrates	0-7	C-reactive protein	Homo sapiens	55-58
9811394-10	1998	In the treatment of hypertension, nitroprusside and nitrates exert their actions via NO donation.	Nitrates	52-60	nitric oxide synthase 2	Homo sapiens	85-87
9759915-3	1998	In this study, the effect of activation P2Z/P2X7 receptor was investigated on the bacterial lipopolysaccharide induced nitric oxide production in RAW 264.7 macrophage call line using the nitrite/nitrate assay.	Nitrates	195-202	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	44-57
9865496-5	1998	Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
9715532-6	1998	Induction of GmNRT2 mRNA levels in roots occurred within 1 h after exposure of plants to nitrate.	Nitrates	89-96	NRT2 protein	Glycine max	13-19
9715532-7	1998	Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate.	Nitrates	0-7	NRT2 protein	Glycine max	21-27
9715532-7	1998	Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate.	Nitrates	86-93	NRT2 protein	Glycine max	21-27
9715532-7	1998	Nitrate induction of GmNRT2 mRNA levels was accompanied by a fourfold increase in net nitrate uptake by soybean roots at 100 microM external nitrate.	Nitrates	141-148	NRT2 protein	Glycine max	21-27
9715532-8	1998	The molecular and physiological evidence indicates that GmNRT2 is probably a high-affinity nitrate transporter involved in nitrate uptake by soybean roots.	Nitrates	91-98	NRT2 protein	Glycine max	56-62
9759949-8	1998	RESULTS: In all of seven specimens from children with increased levels of nitrate/nitrite in the urine, we detected antibodies to iNOS, whereas in five of six control specimens--that is, from children with normal nitrate/nitrite levels--we could not detect any iNOS.	Nitrates	74-81	nitric oxide synthase 2	Homo sapiens	130-134
9698594-9	1998	Both types of asbestos fibers also induced iNOS protein expression and the formation of nitrotyrosine in mesothelial cells and greatly induced the formation of nitrate (NO3-), a surrogate marker of ONOO- formation, in IL-1beta-stimulated cells.	Nitrates	160-167	interleukin 1 beta	Rattus norvegicus	218-226
9865496-5	1998	Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6.	Nitrates	72-79	interferon alpha 1	Homo sapiens	128-131
9865496-5	1998	Our present data show a correlation between the production of nitrite + nitrate (NO2- + NO3-) and that of circulating cytokines IFN and IL-6.	Nitrates	72-79	interleukin 6	Homo sapiens	136-140
9716178-3	1998	In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants.	Nitrates	210-217	tumor necrosis factor	Homo sapiens	37-64
9675176-3	1998	Activated macrophages synthesize NO, which is oxidized in the culture medium by molecular oxygen and superoxide (O2-, also released by the cells), yielding mainly nitrite (NO2-) and nitrate (NO3-) as the respective end products.	Nitrates	182-189	NBL1, DAN family BMP antagonist	Homo sapiens	191-194
9716178-3	1998	In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants.	Nitrates	210-217	interferon gamma	Homo sapiens	66-75
9716178-3	1998	In response to cytokine stimulation (tumor necrosis factor alpha, IFN-gamma, and interleukin 1beta), human pancreatic carcinoma cell lines expressed the inducible NO synthase that synthesizes NO, detectable as nitrate and nitrite in the culture supernatants.	Nitrates	210-217	interleukin 1 beta	Homo sapiens	81-98
9688317-4	1998	Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts.	Nitrates	231-238	myelin basic protein	Rattus norvegicus	28-48
9688317-4	1998	Following immunisation with myelin basic protein (MBP)-complete Freund"s adjuvant (CFA), PVG rats developed higher serum levels of the surrogate markers of nitric oxide production, reactive nitrogen intermediates (RNI; nitrite and nitrate), than did their Lewis counterparts.	Nitrates	231-238	myelin basic protein	Rattus norvegicus	50-53
9691115-4	1998	Maximal second order binding rates between 40,000 and 80,000 (m-1 x sec-1) were obtained for chlorides and nitrates of 1a group alkali ions with the exception of lithium supporting only rates of maximally 10,000 (M-1 x sec-1).	Nitrates	107-115	myoregulin	Homo sapiens	62-65
9708463-1	1998	OBJECTIVES: We sought to assess whether oxidation products of nitric oxide (NO), nitrite (NO2-) and nitrate (NO3-), referred to as NOx, are released by the heart of patients after acute myocardial infarction (AMI) and whether NOx can be determined in peripheral blood of these patients.	Nitrates	100-107	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
9691115-4	1998	Maximal second order binding rates between 40,000 and 80,000 (m-1 x sec-1) were obtained for chlorides and nitrates of 1a group alkali ions with the exception of lithium supporting only rates of maximally 10,000 (M-1 x sec-1).	Nitrates	107-115	secretory blood group 1, pseudogene	Homo sapiens	68-73
9673545-5	1998	We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level.	Nitrates	241-248	nitric oxide synthase 2	Homo sapiens	31-52
9673545-5	1998	We examined mRNA expression of inducible NO synthase (iNOS) in circulating PMNs from those patients pre- and postoperatively using the reverse transcriptase polymerase chain reaction (RT-PCR) method and measured their serum nitrate (NO2-) + nitrate (NO3-) concentration, peripheral blood white cell (WBC) count, and serum C-reactive protein (CRP) level.	Nitrates	241-248	nitric oxide synthase 2	Homo sapiens	54-58
9671763-5	1998	We report here that untreated p53 KO mice excreted 70% more nitrite plus nitrate than mice with wild-type (wt) p53.	Nitrates	73-80	transformation related protein 53, pseudogene	Mus musculus	30-33
9668089-10	1998	5-CHO-THF influx was restored by addition of chloride, fluoride, or nitrate but not by sulfate, phosphate, or ATP which were all inhibitory over a broad range of concentrations.	Nitrates	68-75	thin fur	Mus musculus	6-9
9671763-7	1998	Upon treatment with heat-inactivated Corynebacterium parvum, urinary nitrite plus nitrate excretion of p53 KO mice exceeded that of wt controls by approximately 200%.	Nitrates	82-89	transformation related protein 53, pseudogene	Mus musculus	103-106
9655731-2	1998	It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3).	Nitrates	88-95	nitric oxide synthase 2	Homo sapiens	18-39
9655731-2	1998	It is produced by nitric oxide synthase (NOS) and is rapidly metabolized to nitrite and nitrate (NO2/NO3).	Nitrates	88-95	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
9694586-5	1998	This procedure, supplemented with deproteinization and reduction of nitrates to nitrites in the presence of NADPH-sensitive reductase, can be successfully applied for measurement of NOx levels in human body fluids (serum, urine and CSF).	Nitrates	68-76	colony stimulating factor 2	Homo sapiens	232-235
9639597-0	1998	Functional citric acid cycle in an arcA mutant of Escherichia coli during growth with nitrate under anoxic conditions.	Nitrates	86-93	arginine deiminase	Escherichia coli	35-39
9639597-4	1998	In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway.	Nitrates	102-109	arginine deiminase	Escherichia coli	6-10
9639597-4	1998	In an arcA mutant devoid of the transcriptional regulator ArcA, glycerol was completely oxidized with nitrate as an electron acceptor, demonstrating derepression and function of the complete pathway.	Nitrates	102-109	arginine deiminase	Escherichia coli	58-62
9625727-3	1998	Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P &lt; 0.05).	Nitrates	49-56	glutamic pyruvic transaminase, soluble	Mus musculus	29-32
9662428-1	1998	We examined cytokinin and nitrate responsiveness in gene expression of five distinct response regulator homologs (ARR3-ARR7) in the leaves of nitrogen-starved Arabidopsis plants.	Nitrates	26-33	response regulator 3	Arabidopsis thaliana	114-118
9662428-1	1998	We examined cytokinin and nitrate responsiveness in gene expression of five distinct response regulator homologs (ARR3-ARR7) in the leaves of nitrogen-starved Arabidopsis plants.	Nitrates	26-33	response regulator 7	Arabidopsis thaliana	119-123
9625727-3	1998	Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P &lt; 0.05).	Nitrates	49-56	glutamic pyruvic transaminase, soluble	Mus musculus	151-154
9625727-3	1998	Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P &lt; 0.05).	Nitrates	172-179	glutamic pyruvic transaminase, soluble	Mus musculus	29-32
9625727-3	1998	Regression analysis of serum ALT levels to serum nitrate plus nitrite levels in individual mice revealed a positive, linear relationship between serum ALT levels and serum nitrate plus nitrite levels with a correlation coefficient of 0.9 (P &lt; 0.05).	Nitrates	172-179	glutamic pyruvic transaminase, soluble	Mus musculus	151-154
9573546-7	1998	Kallikrein gene delivery caused a decrease in blood urea nitrogen levels and increases in urinary kinin and nitrite/nitrate levels.	Nitrates	116-123	kallikrein related peptidase 4	Homo sapiens	0-10
9631803-10	1998	IL-10 levels correlated with IL-6 levels (days 1 and 2) and nitrite+nitrate levels (days 1 and 3; p&lt;0.05).	Nitrates	68-75	interleukin 10	Homo sapiens	0-5
9607316-0	1998	Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions.	Nitrates	51-59	xanthine dehydrogenase	Homo sapiens	0-23
9607316-1	1998	Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH.	Nitrates	81-88	xanthine dehydrogenase	Homo sapiens	0-23
9607316-1	1998	Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH.	Nitrates	81-88	xanthine dehydrogenase	Homo sapiens	25-28
9607316-1	1998	Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH.	Nitrates	117-124	xanthine dehydrogenase	Homo sapiens	0-23
9607316-1	1998	Xanthine oxidoreductase (XOR) catalyses the reduction of the therapeutic organic nitrate, nitroglycerin (glyceryl trinitrate, GTN), as well as inorganic nitrate and nitrite, to nitric oxide (NO) under hypoxic conditions in the presence of NADH.	Nitrates	117-124	xanthine dehydrogenase	Homo sapiens	25-28
9626580-5	1998	This Lb-NO species, which has not been previously detected in intact root nodules of plants grown in the absence of nitrate, is thought to be formed by reaction of nitric oxide with iron(II) leghemoglobin.	Nitrates	116-123	leghemoglobin A	Glycine max	5-7
9617881-2	1998	Here we report for the first time that 1400W, a novel and highly selective inhibitor of iNOS activity, attenuates the delayed hypotension as well as the rise in the plasma levels of nitrite/nitrate caused by endotoxin in the rat.	Nitrates	190-197	nitric oxide synthase 2	Rattus norvegicus	88-92
9626903-0	1998	Preventive effects of angiotensin-converting enzyme inhibitors on nitrate tolerance during continuous transdermal application of nitroglycerin in patients with chronic heart failure.	Nitrates	66-73	angiotensin I converting enzyme	Homo sapiens	22-51
9648741-1	1998	Two new nitrate assimilation-related genes, Nrt2;3 and Nar5, have been identified in Chlamydomonas reinhardtii.	Nitrates	8-15	uncharacterized protein	Chlamydomonas reinhardtii	55-59
9648741-3	1998	Like that of the nitrate assimilation genes, expression of the Nrt2;3 gene is down-regulated by ammonium and positively controlled by Nit2, a regulatory locus specific for the pathway.	Nitrates	17-24	uncharacterized protein	Chlamydomonas reinhardtii	134-138
9648741-8	1998	The Nrt2;3 and Nar5 genes are overexpressed in a deletion mutant that lacks nitrate assimilation loci.	Nitrates	76-83	uncharacterized protein	Chlamydomonas reinhardtii	15-19
9628026-6	1998	In whole plants, ZmCip1 transcript was transiently accumulated exclusively in leaves by supply of nitrate or ammonium ions to the roots, whereas the transcript was not accumulated in detached leaves by supply of the nitrogen nutrients.	Nitrates	98-105	cytokinin response regulator 1	Zea mays	17-23
9628026-7	1998	Both the cytokinin- and nitrate-responsive accumulations of ZmCip1 transcript were accompanied by an increase in the immunotitratable protein.	Nitrates	24-31	cytokinin response regulator 1	Zea mays	60-66
9667074-3	1998	A good positive correlation between either serum or gastric mucosal nitrite/nitrate concentration and gastric mucosal iNOS activity in all rats used (r = 0.741 or 0.842, respectively, p &lt; 0.001) was found.	Nitrates	76-83	nitric oxide synthase 2	Rattus norvegicus	118-122
9617881-4	1998	Similarly, administration of another selective inhibitor of iNOS activity, L-NIL, 2 h after endotoxin injection abolished the rise in nitrite/nitrate and attenuated the delayed hypotension caused by endotoxin, but failed to ameliorate organ injury.	Nitrates	142-149	nitric oxide synthase 2	Rattus norvegicus	60-64
9661284-4	1998	Cd2+ (20 microM) stimulated an extensive swelling of nonenergized mitochondria incubated in 125 mM nitrate media, the effect being increased in the series of Li &lt; Na &lt; K &lt; NH4.	Nitrates	99-106	Cd2 molecule	Rattus norvegicus	0-3
9523847-9	1998	A significant decrease in nitrate from preoperative levels in groups A (postoperative day (POD) 1 and 3; p &lt; 0.0005) and B (POD 1, p &lt; 0.0001) was observed; nitrate levels in group C did not decrease for 14 days after surgery.	Nitrates	26-33	coronin 7	Homo sapiens	72-103
9495884-4	1998	Induction of iNOS protein is inferred because urinary nitrate and cGMP levels are increased 4 hr after LPS intravesical instillation and remain elevated for at least 24 hr.	Nitrates	54-61	nitric oxide synthase 2	Rattus norvegicus	13-17
9466545-2	1998	Doxycycline (at 1.5 mg/kg) exerted its protective effect by inhibiting nitrate production by an interleukin-10-independent mechanism.	Nitrates	71-78	interleukin 10	Mus musculus	96-110
9475262-6	1998	Increases in renin activity amounted to 130% (p &lt; 0.001), 117% (p &lt; 0.001), and 112% (p &lt; 0.001) with molsidomine, and to 14, 16%, and 0 (each NS) with the nitrate at the corresponding times.	Nitrates	165-172	renin	Homo sapiens	13-18
9532589-5	1998	Nitrate and nitrite, were raised in the CSF and serum of patients with multiple sclerosis and other inflammatory neurological diseases compared to patients with non-inflammatory neurological disorders (median nitrate and nitrite: cerebrospinal fluid = 10.3 microM vs 15.4 microM vs 6.6 microM, P &lt; 0.001, and serum = 49.0 microM vs 46.4 microM vs 38.8 microM, P = 0.02, respectively).	Nitrates	0-7	colony stimulating factor 2	Homo sapiens	40-43
9514534-9	1998	Endotoxin and interleukin-6 levels increased in a similar manner to nitrate levels, but tumor necrosis factor-alpha and interleukin-1 beta levels did not.	Nitrates	68-75	interleukin 6	Homo sapiens	14-27
9532589-6	1998	CSF nitrate and nitrite levels correlated with the albumin quotient (n = 59, r = 0.42, P &lt; 0.001).	Nitrates	4-11	colony stimulating factor 2	Homo sapiens	0-3
9458730-4	1998	NO production, measured by the accumulation of nitrite and nitrate, was enhanced by 10(-7) M ANG II.	Nitrates	59-66	angiotensinogen	Rattus norvegicus	93-99
9526673-2	1998	The levels of nitrite (NO2-) and nitrate (NO3-) were measured simultaneously by high-performance liquid chromatography (HPLC) with UV detection using the Griess reaction after the reduction of nitrate to nitrite.	Nitrates	33-40	NBL1, DAN family BMP antagonist	Homo sapiens	42-45
9538982-13	1998	Resistance to nitrates, therefore, could be considered another feature of the insulin-resistance syndrome.	Nitrates	14-22	insulin	Homo sapiens	78-85
10684481-2	1998	When nitrates are metabolized to release NO, there is a considerable coproduction of reactive oxygen species (superoxide radical and peroxynitrite) in vessels leading to inactivation of NO, to diminished cyclic quanosine monophosphate production in smooth muscle cells (SMC), to impaired vasomotor responses to the endothelium-derived relaxation factor (EDRF), and to formation of nitrotyrosine as a marker of glyceryltrinitrate (GTN)-induced formation of peroxynitrite.	Nitrates	5-13	alpha hemoglobin stabilizing protein	Homo sapiens	315-352
9453315-8	1998	Tissue slices of the renal cortex and medulla were studied to determine the effects of Ang II and L-NAME on the nitrite/nitrate production.	Nitrates	120-127	angiotensinogen	Rattus norvegicus	87-93
9453315-9	1998	Ang II stimulated the nitrite/nitrate production predominately in the renal medulla, which was significantly attenuated by L-NAME.	Nitrates	30-37	angiotensinogen	Rattus norvegicus	0-6
9456273-2	1998	Up to 8 h after dosing in the morning, more marked and sustained effects were observed with the nitrate (ST at 2 h, -82%; p &lt; 0.001; at 8 h, -64%; p &lt; 0.01) than with molsidomine (2 h, -68%; p &lt; 0.001; at 8 h, -9%; NS).	Nitrates	96-103	signal transducer and activator of transcription 2	Homo sapiens	105-112
10684481-2	1998	When nitrates are metabolized to release NO, there is a considerable coproduction of reactive oxygen species (superoxide radical and peroxynitrite) in vessels leading to inactivation of NO, to diminished cyclic quanosine monophosphate production in smooth muscle cells (SMC), to impaired vasomotor responses to the endothelium-derived relaxation factor (EDRF), and to formation of nitrotyrosine as a marker of glyceryltrinitrate (GTN)-induced formation of peroxynitrite.	Nitrates	5-13	alpha hemoglobin stabilizing protein	Homo sapiens	354-358
9706250-9	1998	We conclude: 1) in addition to decreased granularity in atrial myocardiocytes, high circulating values of ANF here described suggest an increased turnover of the peptide in 2K2C hypertensive rats; 2) lower significant vascular relaxant effects in HT rats would indicate down regulation of ANF receptors in this model; the latter would derive from high plasma ANF concentration and, tentatively, because of greater activity of protein kinase C in the vascular wall; 39 similar values of plasma nitrite/nitrate in SH and HT rats would indicate a comparable NO circulating availability in both groups.	Nitrates	501-508	natriuretic peptide A	Rattus norvegicus	106-109
16793713-1	1998	Limited information seems to be available about the role of reduced endothelial production of endotheliumderived relaxing factor (EDRF)-nitrate/nitrite (NO) in the pathogenesis of diabetic angiopathy in insulindependent diabetes.	Nitrates	136-143	alpha hemoglobin stabilizing protein	Homo sapiens	94-128
9851362-5	1998	In addition, the above-mentioned changes in iNOS activity and LPO and NP-SH concentrations with lesion development in the gastric mucosa of rats with WIR stress were attenuated with both prevention of the lesion development and an increase in the concentration of gastric mucosal nitrite/nitrate, the breakdown products of NO, by pretreatment with aminoguanidine, a selective iNOS inhibitor.	Nitrates	288-295	nitric oxide synthase 2	Rattus norvegicus	44-48
16793713-1	1998	Limited information seems to be available about the role of reduced endothelial production of endotheliumderived relaxing factor (EDRF)-nitrate/nitrite (NO) in the pathogenesis of diabetic angiopathy in insulindependent diabetes.	Nitrates	136-143	alpha hemoglobin stabilizing protein	Homo sapiens	130-134
16793713-5	1998	A significant and inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented.	Nitrates	41-48	thrombomodulin	Homo sapiens	124-138
9455975-0	1997	Changes in nitrite and nitrate (NO2-/NO3-) levels in cerebrospinal fluid of patients with multiple sclerosis.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
9505412-1	1997	Over the last 20 years, dietary nitrate has been implicated in the formation of methemoglobin and carcinogenic nitrosamines in humans.	Nitrates	32-39	hemoglobin subunit gamma 2	Homo sapiens	80-93
9437522-4	1997	Intermediate 5, or the secondary products derived from it, decays to give NO3- and regenerated aldehyde, with small but significant yields of H2O2, organic acids, and organic nitrates.	Nitrates	175-183	NBL1, DAN family BMP antagonist	Homo sapiens	74-77
9326589-4	1997	CooA is a member of a family of transcriptional regulators similar to the cAMP receptor protein and fumavate nitrate reduction from Escherichia coli.	Nitrates	109-116	CS1 fimbrial subunit A precursor	Escherichia coli	0-4
9421934-8	1997	Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT.	Nitrates	78-85	ferredoxin-dependent glutamate synthase, Fd-GOGAT	Hordeum vulgare	113-121
9421934-8	1997	Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT.	Nitrates	78-85	ferredoxin-dependent glutamate synthase, Fd-GOGAT	Hordeum vulgare	147-155
9421934-8	1997	Compared with plants grown in N-free medium, light-grown plants supplied with nitrate had almost two-fold higher Fd-GOGAT activities and increased Fd-GOGAT mRNA levels, but nitrate had no effect on the abundance of the enzyme or its mRNA in etiolated plants, indicating that light is required for nitrate induction of barley Fd-GOGAT.	Nitrates	78-85	ferredoxin-dependent glutamate synthase, Fd-GOGAT	Hordeum vulgare	147-155
9366711-9	1997	Nitrite and nitrate levels of the liver, ileum, and blood were higher in the iNOS+/+ mice (P &lt; .05).	Nitrates	12-19	nitric oxide synthase 2, inducible	Mus musculus	77-81
9337353-0	1997	Nitrate plasma level as a marker of nitric oxide production after subcutaneous interleukin 2 immunotherapy.	Nitrates	0-7	interleukin 2	Homo sapiens	79-92
9312089-5	1997	ATPase activity was strictly dependent on the presence of Na+ or Li+ ions and was inhibited by nitrate, N-ethylmaleimide, and the peptide antibiotic destruxin B.	Nitrates	95-102	ATPase	Enterococcus faecalis	0-6
9378986-6	1997	The PDTC concentration-dependent reductions in iNOS activity produced similar decreases in plasma nitrite/nitrate concentrations.	Nitrates	106-113	nitric oxide synthase 2	Rattus norvegicus	47-51
9312089-6	1997	When the purified ATPase was reconstituted into liposomes prepared from Enterococcus faecalis phospholipids, ATP-driven Na+ uptake was observed; uptake was blocked by nitrate, destruxin B, and monensin, but it accelerated by carbonyl cyanide m-chlorophenylhydrazone and valinomycin.	Nitrates	167-174	ATPase	Enterococcus faecalis	18-24
9357468-4	1997	We therefore examined whether the plasma levels of nitrite (NO2-) and nitrate (NO3-) ions increased after arterial reconstruction in patients with arteriosclerosis obliterans (ASO).	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
9402285-3	1997	Both follicular nitrite (r = 0.42, P &lt; 0.01) and nitrate (r = 0.49, P &lt; 0.001) were found to be significantly correlated with follicular IL-1beta concentrations.	Nitrates	52-59	interleukin 1 beta	Homo sapiens	143-151
9402285-5	1997	When follicular cells were incubated in vitro with 10 ng/ml of IL-1beta for 24 h, nitrate generation was significantly (P &lt; 0.01) elevated compared with the control.	Nitrates	82-89	interleukin 1 beta	Homo sapiens	63-71
21639276-6	1997	The tip diameter was down to 20 mum, and the sensors exhibited perfectly linear responses to nitrate in both freshwater and seawater.	Nitrates	93-100	latexin	Homo sapiens	32-35
9314409-8	1997	Human eNOS gene delivery induces significant increases in urinary and aortic cGMP levels and urinary and serum nitrite/nitrate content (P&lt;.05), while no significant differences in body weight, heart rate, water intake, food consumption, or urine excretion were observed.	Nitrates	119-126	nitric oxide synthase 3	Homo sapiens	6-10
9295837-1	1997	OBJECTIVES: To examine the relationship between circulating methemoglobin and nitrite/nitrate concentrations and to compare these markers of nitric oxide overproduction with clinical variables in children diagnosed with septic shock.	Nitrates	86-93	hemoglobin subunit gamma 2	Homo sapiens	60-73
9316879-3	1997	We found that chronic proteasome inhibition using MG-341 significantly attenuated the peptidoglycan/polysaccharide (PG/PS)-induced up-regulation of iNOS in the colon and spleen and the consequent increase in plasma levels of nitrate and nitrite.	Nitrates	225-232	nitric oxide synthase 2	Homo sapiens	148-152
9242548-5	1997	The NO release from iNOS-transfected cells, as measured by nitrite and nitrate accumulation and by cyclic guanosine monophosphate (cGMP) increases in rat reporter cells, was inhibitable (P &lt; .01 for both) with N(omega)-methyl-L-arginine (L-NMA), a NOS inhibitor.	Nitrates	71-78	nitric oxide synthase 2	Rattus norvegicus	20-24
9452775-8	1997	In the case of contraindication or impossibility of using angiotensin converting enzyme inhibitors, a combination of high doses of nitrates and hydralazine may be justified.	Nitrates	131-139	angiotensin I converting enzyme	Homo sapiens	58-87
9242464-5	1997	Inhibition of iNOS in vivo was confirmed by decreases in plasma nitrite + nitrate concentrations in treated animals compared with that of controls (63-83% decreases for all experiments) and was supported by plasma and tumor concentrations of 1400W that were equivalent and 2.6-4.9 times higher than the EC50 previously reported for iNOS in a tissue assay.	Nitrates	74-81	nitric oxide synthase 2, inducible	Mus musculus	14-18
9252519-4	1997	Dose-dependent inhibition of interleukin-1 beta- and interferon-gamma-stimulated nitrite/nitrate production was observed when cells were preincubated for 6 h with UDCA (0-800 microM), and a substantial inhibition (81 +/- 3.2%) was seen at 500 microM.	Nitrates	89-96	interleukin 1 beta	Homo sapiens	29-69
9452775-9	1997	On the other hand, when angiotensin converting enzyme inhibitors are already prescribed, nitrates can only be considered to improve symptoms in the case of persistence of dyspnoea.	Nitrates	89-97	angiotensin I converting enzyme	Homo sapiens	24-53
9201027-6	1997	Production of NO metabolites (nitrate and nitrite), measured as their coronary arteriovenous differencexCBF, was significantly increased after 1 to 2 days of CAR, both at baseline (153 +/- 56%) and during BK infusion (220 +/- 76%) (P &lt; .05).	Nitrates	30-37	kininogen 1	Canis lupus familiaris	205-207
12223754-4	1997	SS mRNA was greatly reduced in nodules of drought-, salt-, and nitrate-treated plants; however, this was not correlated with changes in soluble carbohydrate, starch, amino acids, or ureides.	Nitrates	63-70	sucrose synthase	Glycine max	0-2
9227507-6	1997	In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma.	Nitrates	103-110	tumor necrosis factor	Rattus norvegicus	130-157
9227507-6	1997	In the current study, we demonstrate that L2 cells generate the oxidative products of NO., nitrite and nitrate, after exposure to tumor necrosis factor-alpha, lipopolysaccharide, and interferon-gamma.	Nitrates	103-110	interferon gamma	Rattus norvegicus	183-199
9193097-0	1997	A nitrate-inducible ferredoxin in maize roots.	Nitrates	2-9	ferredoxin	Zea mays	20-30
12223730-3	1997	The induction of nitrate reductase (NR) activity was reduced at both external nitrate concentrations.	Nitrates	17-24	nitrate reductase [NADH] 1	Zea mays	36-38
9193097-2	1997	We have identified and characterized a nitrate-inducible ferredoxin (Fd) in maize (Zea mays L.) roots by structural analysis of the purified protein and by cloning of its cDNA and gene.	Nitrates	39-46	ferredoxin	Zea mays	57-67
9193097-2	1997	We have identified and characterized a nitrate-inducible ferredoxin (Fd) in maize (Zea mays L.) roots by structural analysis of the purified protein and by cloning of its cDNA and gene.	Nitrates	39-46	ferredoxin	Zea mays	69-71
9193097-3	1997	In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date.	Nitrates	73-80	ferredoxin	Zea mays	9-11
9193097-3	1997	In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date.	Nitrates	73-80	ferredoxin	Zea mays	91-93
9193097-3	1997	In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date.	Nitrates	73-80	ferredoxin-6, chloroplastic	Zea mays	143-148
9193097-3	1997	In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date.	Nitrates	73-80	ferredoxin	Zea mays	91-93
9193097-3	1997	In maize Fd isoproteins are encoded by a small multigene family, and the nitrate-inducible Fd was identified as a novel isoprotein, designated Fd VI, which differed from an Fd I to Fd V identified to date.	Nitrates	73-80	ferredoxin	Zea mays	91-93
9193097-5	1997	However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase.	Nitrates	50-57	ferredoxin-6, chloroplastic	Zea mays	86-91
9193097-5	1997	However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase.	Nitrates	50-57	ferredoxin-6, chloroplastic	Zea mays	166-171
9193097-5	1997	However, during the induction of the capacity for nitrate assimilation, the amount of Fd VI increased markedly within 24 h. Concurrently, the level of transcript for Fd VI increased, but more quickly, reaching a maximal level within 2 h with kinetics similar to those of nitrite reductase and Fd-NADP+ reductase.	Nitrates	50-57	ferredoxin--nitrite reductase, chloroplastic	Zea mays	271-288
9193097-8	1997	These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids.	Nitrates	99-106	ferredoxin-6, chloroplastic	Zea mays	25-30
9193097-8	1997	These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids.	Nitrates	99-106	ferredoxin	Zea mays	25-27
9193097-8	1997	These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids.	Nitrates	99-106	ferredoxin	Zea mays	153-155
9193097-8	1997	These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids.	Nitrates	99-106	ferredoxin--nitrite reductase, chloroplastic	Zea mays	281-298
9193097-8	1997	These data indicate that Fd VI is co-induced with the previously characterized enzymes involved in nitrate assimilation, and they suggest that the novel Fd isoprotein, distinct from the constitutively expressed Fd, might play an important role as an electron carrier from NADPH to nitrite reductase and other Fd-dependent enzymes in root plastids.	Nitrates	99-106	ferredoxin	Zea mays	153-155
9211013-2	1997	Additional efficacy stems from the ability of the nitrates to replenish the deficient endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in patients with coronary heart disease and also to inhibit platelet aggregation.	Nitrates	50-58	alpha hemoglobin stabilizing protein	Homo sapiens	86-121
9146896-16	1997	Similarly, segments of rat aorta released detectable levels of nitrite and nitrate, which were reduced by NG-nitro-L-arginine methyl ester (L-NAME, 1 mM), which inhibits all isoforms of NOS, and by dexamethasone (1 microM), which inhibits the induction of iNOS.	Nitrates	75-82	nitric oxide synthase 2	Rattus norvegicus	256-260
9211013-2	1997	Additional efficacy stems from the ability of the nitrates to replenish the deficient endothelium-derived relaxing factor (EDRF), nitric oxide (NO), in patients with coronary heart disease and also to inhibit platelet aggregation.	Nitrates	50-58	alpha hemoglobin stabilizing protein	Homo sapiens	123-127
9211013-12	1997	However, in the GISSI 3 study, the combination of nitrates with an angiotensin-converting enzyme (ACE) inhibitor reduced mortality risks by 17% in patients with acute myocardial infarction.	Nitrates	50-58	angiotensin I converting enzyme	Homo sapiens	98-101
9133470-4	1997	iNOS expression in allografts resulted in elevated serum nitrite/nitrate levels, indicative of increased in vivo nitric oxide (NO) production.	Nitrates	65-72	nitric oxide synthase 2	Rattus norvegicus	0-4
9136006-1	1997	In Chlamydomonas reinhardtii, the genes required for nitrate assimilation, including the gene encoding nitrate reductase (NIT1), are subject to repression by ammonia.	Nitrates	53-60	uncharacterized protein	Chlamydomonas reinhardtii	103-120
9136006-1	1997	In Chlamydomonas reinhardtii, the genes required for nitrate assimilation, including the gene encoding nitrate reductase (NIT1), are subject to repression by ammonia.	Nitrates	53-60	uncharacterized protein	Chlamydomonas reinhardtii	122-126
12237366-6	1997	After adding 12 mM nitrate to nitrate-limited Nia30(145), the transcripts for NR and phosphoenolpyruvate carboxylase increased, and the transcripts for ADP-glucose pyrophosphorylase decreased within 2 and 4 hr, respectively.	Nitrates	19-26	phosphoenolpyruvate carboxylase	Nicotiana tabacum	85-116
12237366-6	1997	After adding 12 mM nitrate to nitrate-limited Nia30(145), the transcripts for NR and phosphoenolpyruvate carboxylase increased, and the transcripts for ADP-glucose pyrophosphorylase decreased within 2 and 4 hr, respectively.	Nitrates	30-37	phosphoenolpyruvate carboxylase	Nicotiana tabacum	85-116
9133470-8	1997	CONCLUSIONS: (1) iNOS expression and increased NO production occurred during the early stages of acute rejection, persisted throughout the unmodified rejection process, and localized to infiltrating inflammatory cells, but not allograft parenchymal cells; (2) aminoguanidine ameliorated the histological and functional changes of acute rejection; and (3) increased NO production, detected by the presence of iNOS mRNA, protein, or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection.	Nitrates	472-479	nitric oxide synthase 2	Rattus norvegicus	17-21
9114772-0	1997	The alpha-1 adrenergic blocking agent urapidil counteracts postrotational atherectomy "elastic recoil" where nitrates have failed.	Nitrates	109-117	adrenoceptor alpha 1D	Homo sapiens	4-11
9168158-5	1997	A protein-mediated passive transport of nitrate was first demonstrated by the ability of NO3- to electrically short-circuit the (H+)ATPase in plasma membrane vesicles and not in liposomes containing only the purified enzyme.	Nitrates	40-47	ATPase	Zea mays	129-138
9281893-1	1997	A simple and sensitive HPLC validated method was developed for the simultaneous determination of ITF 296 (a new orally active nitrate) and its metabolites ITF 1124 and ITF 1577 in biological samples.	Nitrates	126-133	trefoil factor 3	Homo sapiens	97-100
9175238-7	1997	An inverse correlation of nitrate/nitrite excretion with endothelial markers (von Willebrand factor, soluble thrombomodulin) was documented in NIDDM, this correlation was much stronger in IDDM.	Nitrates	26-33	thrombomodulin	Homo sapiens	109-123
9175238-8	1997	Moreover, in IDDM patients reduced nitrate/nitrite excretion was strongly associated with elevated plasmatic beta-thromboglobulin levels.	Nitrates	35-42	pro-platelet basic protein	Homo sapiens	109-129
9175238-10	1997	In IDDM the decreased nitrate/nitrite excretion may also lead to increased in vivo platelet activation, which suggests that the reduced amount of EDRF-NO might play a role in the pathogenesis of angiopathy in IDDM.	Nitrates	22-29	alpha hemoglobin stabilizing protein	Homo sapiens	146-150
9161026-1	1997	Higher plant nitrite reductase (NiR) is a monomeric chloroplastic protein catalysing the reduction of nitrite, the product of nitrate reduction, to ammonium.	Nitrates	126-133	nitrite reductase 1	Arabidopsis thaliana	13-30
9161026-1	1997	Higher plant nitrite reductase (NiR) is a monomeric chloroplastic protein catalysing the reduction of nitrite, the product of nitrate reduction, to ammonium.	Nitrates	126-133	nitrite reductase 1	Arabidopsis thaliana	32-35
9161026-5	1997	When these plants were grown in vitro on media containing either nitrate or ammonium as sole nitrogen source, NiR mRNA derived from transgene expression was constitutively expressed, whereas NiR activity and protein level were strongly reduced on ammonium-containing medium.	Nitrates	65-72	nitrite reductase 1	Arabidopsis thaliana	110-113
9161026-5	1997	When these plants were grown in vitro on media containing either nitrate or ammonium as sole nitrogen source, NiR mRNA derived from transgene expression was constitutively expressed, whereas NiR activity and protein level were strongly reduced on ammonium-containing medium.	Nitrates	65-72	nitrite reductase 1	Arabidopsis thaliana	191-194
9093135-4	1997	NO is an unstable compound with a short half-life;it is easily converted to nitrite (NO2) and nitrate (NO3).	Nitrates	94-101	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
9110418-5	1997	Similarly, LPS-induced production of nitrite/nitrate (breakdown products of nitric oxide) was not affected by verapamil and diltiazem.	Nitrates	45-52	toll-like receptor 4	Mus musculus	11-14
9065390-4	1997	The transformants carrying nit1/ars did not express arylsulphatase when grown in ammonium-sufficient medium but readily accumulated the enzyme in ammonium-free medium either supplemented, or not supplemented, with nitrate or nitrite.	Nitrates	214-221	uncharacterized protein	Chlamydomonas reinhardtii	27-31
9023196-0	1997	Cloning and sequence of cymA, a gene encoding a tetraheme cytochrome c required for reduction of iron(III), fumarate, and nitrate by Shewanella putrefaciens MR-1.	Nitrates	122-129	cytochrome c	Shewanella oneidensis MR-1	24-28
9087877-7	1997	CONCLUSIONS: These results, together with our previous demonstration that iNOS inhibition ameliorated lung allograft rejection, suggest that (1) iNOS expression and increased NO production contributed to acute rejection of the transplanted lung, (2) iNOS inhibition may offer an alternative in management of acute lung allograft rejection, and (3) increased NO production, detected by the presence of iNOS mRNA or protein or noninvasively by measuring serum nitrite/nitrate levels, may serve as an early marker of acute allograft rejection.	Nitrates	466-473	nitric oxide synthase 2	Rattus norvegicus	74-78
9085575-2	1997	We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484).	Nitrates	113-120	NPK1-related protein kinase 1	Arabidopsis thaliana	89-92
9085575-2	1997	We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484).	Nitrates	113-120	NPK1-related protein kinase 2	Arabidopsis thaliana	97-100
9085575-2	1997	We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484).	Nitrates	113-120	nitrate reductase 1	Arabidopsis thaliana	137-140
9085575-2	1997	We demonstrated previously that 238 and 330 bp of the 5" flanking regions, designated as NP1 and NP2, of the two nitrate reductase genes NR1 and NR2, respectively, are sufficient for nitrate-dependent transcription (Y. Lin, C.-F. Hwang, J.B. Brown, C.-L. Cheng [1994] Plant Physiol 106: 477-484).	Nitrates	113-120	nitrate reductase 2	Arabidopsis thaliana	145-148
9085575-3	1997	Here we identify the cis-acting elements of NP1 and NP2 that are necessary for nitrate-dependent transcription by linker-scanning (LS) analysis.	Nitrates	79-86	NPK1-related protein kinase 1	Arabidopsis thaliana	44-47
9085575-3	1997	Here we identify the cis-acting elements of NP1 and NP2 that are necessary for nitrate-dependent transcription by linker-scanning (LS) analysis.	Nitrates	79-86	NPK1-related protein kinase 2	Arabidopsis thaliana	52-55
9085575-4	1997	In transgenic plants one LS mutant of NP1 and two LS mutants of NP2 exhibited significantly lower nitrate-induced reporter gene chloramphenicol acetyltransferase activity.	Nitrates	98-105	NPK1-related protein kinase 1	Arabidopsis thaliana	38-41
9085575-4	1997	In transgenic plants one LS mutant of NP1 and two LS mutants of NP2 exhibited significantly lower nitrate-induced reporter gene chloramphenicol acetyltransferase activity.	Nitrates	98-105	NPK1-related protein kinase 2	Arabidopsis thaliana	64-67
9085575-6	1997	The single LS mutant in NP1 lost its response to nitrate, whereas the two LS mutants in NP2 partially lost their response to nitrate.	Nitrates	49-56	NPK1-related protein kinase 1	Arabidopsis thaliana	24-27
9085575-6	1997	The single LS mutant in NP1 lost its response to nitrate, whereas the two LS mutants in NP2 partially lost their response to nitrate.	Nitrates	125-132	NPK1-related protein kinase 2	Arabidopsis thaliana	88-91
9071565-4	1997	Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII).	Nitrates	6-13	interleukin 6	Homo sapiens	84-88
9071565-4	1997	Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII).	Nitrates	6-13	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
9071565-4	1997	Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII).	Nitrates	6-13	tumor necrosis factor	Homo sapiens	96-105
9071565-4	1997	Serum nitrate levels correlated significantly with both pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) as well as anti-inflammatory cytokines (IL-10, TNFsrI, TNFsrII).	Nitrates	6-13	interleukin 10	Homo sapiens	147-152
9023196-2	1997	This gene complemented a mutant which had a TnphoA insertion in cymA and which was deficient in the respiratory reduction of iron(III), nitrate, fumarate, and manganese(IV).	Nitrates	136-143	cytochrome c	Shewanella oneidensis MR-1	64-68
8994427-11	1997	CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation.	Nitrates	148-156	fibrinogen beta chain	Homo sapiens	192-202
9020872-0	1997	The YNT1 gene encoding the nitrate transporter in the yeast Hansenula polymorpha is clustered with genes YNI1 and YNR1 encoding nitrite reductase and nitrate reductase, and its disruption causes inability to grow in nitrate.	Nitrates	27-34	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	4-8
9020872-2	1997	Disruption of the chromosomal YNT1 copy resulted in incapacity to grow in nitrate and a significant reduction in rate of nitrate uptake.	Nitrates	74-81	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	30-34
9020872-2	1997	Disruption of the chromosomal YNT1 copy resulted in incapacity to grow in nitrate and a significant reduction in rate of nitrate uptake.	Nitrates	121-128	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	30-34
9020872-4	1997	Northern-blot analysis showed that YNT1 is expressed when the yeast is grown in nitrate and nitrite but not in ammonium solution.	Nitrates	80-87	proteasome regulatory particle base subunit RPT3	Saccharomyces cerevisiae S288C	35-39
8994427-11	1997	CONCLUSIONS: The three main classes of antianginal medication have different and possible clinically relevant effects on platelet behavior in vivo, nitrates causing inhibition of aggregation (fibrinogen binding) and degranulation (P-selectin expression), calcium antagonists enhancing degranulation, and beta-blockers enhancing aggregation.	Nitrates	148-156	selectin P	Homo sapiens	231-241
9001323-6	1997	Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956).	Nitrates	77-84	tumor necrosis factor	Mus musculus	14-17
8995407-5	1997	The spectra obtained for the adducts formed with halides, pseudohalides, trichloroacetate, nitrate, imidazole, and 1-methylimidazole appear to be representative of near tetrahedral Co(II) geometries.	Nitrates	91-98	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-187
9001323-6	1997	Antibodies to TNF and/or IL-1 significantly reduced the nitrite or nitrite + nitrate concentrations and the concentrations of TNF and IL-1 in the M-CM correlated with nitrite concentrations in the LA-4 culture supernatant fluids (r2 = 0.848 and 0.956).	Nitrates	77-84	interleukin 1 complex	Mus musculus	25-29
8985206-8	1997	Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations.	Nitrates	122-129	interferon gamma	Homo sapiens	41-50
9503598-4	1997	The ranges of SCP under the influence of temperature, light, nitrate, ammonia, phosphorus, iron, carbonate, and sodium chloride were in the following respective order (% dry wt): 18.4-43.3, 20.5-42.3, 12.4-35.8, 15.7-41.8, 15.8-49.4, 17.4-49.7, 13.8-35.6, and 0.0-37.7.	Nitrates	61-68	solute carrier family 50 member 1	Homo sapiens	14-17
8985206-8	1997	Nitrite accumulation in experiments with IFN-gamma/IL-4 in human monocytes appears to be an in vitro artifact produced by nitrate-reducing activities contained in cytokine preparations.	Nitrates	122-129	interleukin 4	Homo sapiens	51-55
9411502-4	1997	The mean +/- levels of nitrite and nitrate in CSF on admission were higher in patients with BM in comparison with controls and in children with viral meningitis.	Nitrates	35-42	colony stimulating factor 2	Homo sapiens	46-49
9010412-0	1997	A rostrocaudal gradient of nitrate plus nitrite concentrations in CSF.	Nitrates	27-34	colony stimulating factor 2	Homo sapiens	66-69
8981915-13	1996	Treatment with recombinant human growth hormone normalizes urinary nitrate and cyclic GMP excretion, possibly via IGF-1 stimulation of endothelial NO formation, and concomitantly decreases peripheral arterial resistance.	Nitrates	67-74	growth hormone 1	Homo sapiens	33-47
9035296-8	1997	The plasma level of nitrate/nitrite increased from 20 to 260 and 1000 microM 4 and 16 h, respectively, 20 mg/kg NMLA abolished NO production at 4 h, while MP inhibited it for up to 16 h. The hepatic malondialdehyde level increased from 0.50 to 2.46 nmol/mg protein at 4 h. Administration of anti-CD18 and MP reduced the level to 1.80 and 1.41 nmol/mg protein, respectively, whereas NMLA did not affect it.	Nitrates	20-27	integrin beta 2	Mus musculus	296-300
15336795-5	2004	Nitrate reduction was likely due to microbial degradation of accumulated organic matter coupled with successive consumption of O2 and NO3- in the macropore water followed by reductive dissolution of Fe and Mn from minerals along the macropores.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
8943494-1	1996	Nitric oxide (NO) is readily oxidized to nitrate and nitrite and NO activates guanylyl cyclase, increasing cyclic GMP levels.	Nitrates	41-48	5'-nucleotidase, cytosolic II	Homo sapiens	114-117
8989878-0	1996	CHL1 encodes a component of the low-affinity nitrate uptake system in Arabidopsis and shows cell type-specific expression in roots.	Nitrates	45-52	nitrate transporter 1.1	Arabidopsis thaliana	0-4
8989878-1	1996	The Arabidopsis CHL1 (AtNRT1) gene confers sensitivity to the herbicide chlorate and encodes a nitrate-regulated nitrate transporter.	Nitrates	95-102	nitrate transporter 1.1	Arabidopsis thaliana	16-20
8989878-1	1996	The Arabidopsis CHL1 (AtNRT1) gene confers sensitivity to the herbicide chlorate and encodes a nitrate-regulated nitrate transporter.	Nitrates	95-102	nitrate transporter 1.1	Arabidopsis thaliana	22-28
8989878-2	1996	However, how CHL1 participates in nitrate uptake in plants is not yet clear.	Nitrates	34-41	nitrate transporter 1.1	Arabidopsis thaliana	13-17
8989878-4	1996	Under most conditions tested, the amount of nitrate uptake by a chl1 deletion mutant was found to be significantly less than that of the wild type.	Nitrates	44-51	nitrate transporter 1.1	Arabidopsis thaliana	64-68
8989878-7	1996	These results are consistent with the involvement of CHL1 in nitrate uptake at different stages of root cell development.	Nitrates	61-68	nitrate transporter 1.1	Arabidopsis thaliana	53-57
8989878-8	1996	A functional analysis in Xenopus oocytes indicated that CHL1 is a low-affinity nitrate transporter with a K(m) value of approximately 8.5 mM for nitrate.	Nitrates	79-86	DEAD/H-box helicase 11 L homeolog	Xenopus laevis	56-60
8938409-5	1996	CYCD3 (delta 3) transcript levels were strongly dependent on nitrate, and were induced at the G1/S transition following phytohormone readdition.	Nitrates	61-68	CYCLIN D3;1	Arabidopsis thaliana	0-5
8953249-4	1996	Transcripts for ZmSUMT1 accumulated rapidly in both rots and leaves in response to the addition of nitrate to the culture medium.	Nitrates	99-106	siroheme uroporphyrinogen methyltransferase 1	Zea mays	16-23
8953249-5	1996	The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase.	Nitrates	45-52	siroheme uroporphyrinogen methyltransferase 1	Zea mays	89-96
8883421-0	1996	Plasma nitrate plus nitrite changes during continuous intravenous infusion interleukin 2.	Nitrates	7-14	interleukin 2	Homo sapiens	75-88
8953249-5	1996	The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase.	Nitrates	45-52	nitrate reductase [NADH] 1	Zea mays	177-194
8953249-5	1996	The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase.	Nitrates	45-52	ferredoxin--nitrite reductase, chloroplastic	Zea mays	199-216
8953249-5	1996	The effects of biochemical inhibitors on the nitrate-dependent induction of the gene for ZmSUMT1 coincided with the effects on the genes for other nitrate-assimilatory enzymes, nitrate reductase and nitrite reductase.	Nitrates	147-154	siroheme uroporphyrinogen methyltransferase 1	Zea mays	89-96
8953249-7	1996	The results together indicate that ZmSUMT1 might be involved in the synthesis of siroheme, a prosthetic group of nitrite reductase, and that the expression of its gene is co-regulated with that of other nitrate-assimilatory genes.	Nitrates	203-210	siroheme uroporphyrinogen methyltransferase 1	Zea mays	35-42
8937711-18	1996	in conscious unrestrained rats, 2-amino-4-methylpyridine inhibited the rise in plasma nitrate produced in response to intraperitoneal injection of LPS (ID50 = 0.009 mg kg-1 min-1).	Nitrates	86-93	toll-like receptor 4	Mus musculus	147-150
8937711-23	1996	2-Amino-4-methylpyridine also inhibited LPS-induced elevation in plasma nitrate after either subcutaneous (ID50 = 0.3 mg kg-1) or oral (ID50 = 20.8 mg kg-1) administration.	Nitrates	72-79	toll-like receptor 4	Mus musculus	40-43
8883421-12	1996	We conclude that determination of plasma nitrate + nitrite levels during CIVI IL-2 can usefully estimate, in a dose-dependent pattern, the degree of peripheral vascular relaxation and capillary leakage associated with cytokine action, clinically manifested as hypotension.	Nitrates	41-48	interleukin 2	Homo sapiens	78-82
8864137-20	1996	Serum levels of tumor necrosis factor-alpha (TNF-alpha and nitrite/nitrate in IFN-gamma-treated mice were similar to those of controls.	Nitrates	67-74	interferon gamma	Mus musculus	78-87
9064335-6	1996	Blood mononuclear cells from RA patients had increased NOS activity and increased NOS2 antigen content as compared to those from normal subjects, and responded to interferon-gamma with increased NOS expression and nitrite/nitrate production in vitro.	Nitrates	222-229	interferon gamma	Homo sapiens	163-179
8906612-4	1996	In addition, the mutant SOD protein may function as a peroxidase to oxidize cellular components, and it may also react with peroxynitrite-a product of the reaction between superoxide and nitric oxide-to ultimately form nitrate proteins.	Nitrates	219-226	superoxide dismutase 1	Homo sapiens	24-27
8884978-9	1996	On study admission and at 2-h intervals, plasma CGRP concentrations correlated directly with nitrite and nitrate values.	Nitrates	105-112	calcitonin related polypeptide alpha	Homo sapiens	48-52
8950496-14	1996	Patients taking nitrates had lower activation; after eliminating these patients, GPIIb/IIIa ligand binding was greater among patients with restenosis at both 1 and 2 min (P = 0.04 for both).	Nitrates	16-24	integrin subunit alpha 2b	Homo sapiens	81-86
8923042-3	1996	Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p &gt; 0.05).	Nitrates	33-40	TNF receptor superfamily member 1A	Homo sapiens	216-219
8923042-3	1996	Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p &gt; 0.05).	Nitrates	33-40	TNF receptor superfamily member 1B	Homo sapiens	224-227
8923042-3	1996	Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p &gt; 0.05).	Nitrates	33-40	interferon gamma	Homo sapiens	307-323
8923042-3	1996	Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p &gt; 0.05).	Nitrates	33-40	interleukin 10	Homo sapiens	327-341
8912158-11	1996	After RY, nitrite/nitrate concentration increased to 22.7 +/- 30.1, 32.4 +/- 21.4 and 44.6 +/- 32.7 mol/l in RY1, RY2 and RY3, respectively; in RY45, serum nitrite/nitrate concentration was normal averaging 6.1 +/- 1.2 mol/l.	Nitrates	18-25	small nuclear ribonucleoprotein U4/U6.U5 subunit 27	Rattus norvegicus	109-112
8902940-5	1996	Selective inhibition of iNOS with mercaptoethylguanidine (MEG) reduced plasma nitrite/nitrate levels, but did not prevent the development of vascular hyporeactivity, and did not improve survival in this model of CLP.	Nitrates	86-93	nitric oxide synthase 2	Rattus norvegicus	24-28
8806782-11	1996	However, ONOO., formed by the reaction of .NO and O2.-, nitrates SP-A leading to decreased ability to aggregate lipids and bind mannose.	Nitrates	56-64	surfactant protein A1	Homo sapiens	65-69
8921069-2	1996	Our aim was to study follicular nitrite and nitrate (NO3/NO2) levels in women undergoing in-vitro fertilization (IVF), and to examine their relationship to follicular size, oestradiol concentrations, and ovarian artery and intra-ovarian blood flow as measured by Doppler ultrasound.	Nitrates	44-51	NBL1, DAN family BMP antagonist	Homo sapiens	53-56
8923042-3	1996	Maximal plasma concentrations of nitrate plus nitrite were correlated to the degree of hypotension (r = -0.64, p = 0.02) and levels of tumor necrosis factor (TNF)-alpha (r = 0.51, p = 0.05) and soluble TNF receptors p55 and p75 (r = 0.58, p = 0.03 and r = 0.54, p = 0.04, respectively) but not to levels of interferon-gamma or interleukin-10 (p &gt; 0.05).	Nitrates	33-40	tumor necrosis factor	Homo sapiens	135-168
8702535-5	1996	Planar nitrate, NO3-, is isosteric with the PO3 moiety of a phosphotransfer transition state.	Nitrates	7-14	NBL1, DAN family BMP antagonist	Homo sapiens	16-19
8799195-1	1996	Two mutations have been found in a gene (NRT2) of Arabidopsis thaliana that specifically impair constitutive, high-affinity nitrate uptake.	Nitrates	124-131	nitrate transporter 2:1	Arabidopsis thaliana	41-45
8799195-7	1996	These results indicate that NRT2 is a critical and perhaps necessary gene for constitutive, high-affinity nitrate uptake in Arabidopsis, but not for inducible, high-affinity nor constitutive, low-affinity nitrate uptake.	Nitrates	106-113	nitrate transporter 2:1	Arabidopsis thaliana	28-32
9132576-1	1996	Health effects associated with ingestion of nitrate-contaminated water have included methemoglobinemia (i.e., blue baby syndrome) in infants and spontaneous abortions in laboratory animals and livestock; however, only one study in humans has reported an association between increased methemoglobin levels and spontaneous abortion.	Nitrates	44-51	hemoglobin subunit gamma 2	Homo sapiens	85-98
8842573-9	1996	The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate.	Nitrates	30-37	interleukin 1 receptor like 1	Homo sapiens	46-68
8694791-7	1996	In the presence of nitrate the delta ynil::URA3 mutant extrudes approx.	Nitrates	19-26	orotidine-5'-phosphate decarboxylase	Saccharomyces cerevisiae S288C	43-47
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	272-279	interleukin 1 beta	Rattus norvegicus	66-84
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	272-279	tumor necrosis factor	Rattus norvegicus	98-125
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	272-279	interferon gamma	Rattus norvegicus	139-155
8760140-2	1996	Stimulation of rat pleural mesothelial cells with combinations of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), and LPS induced the synthesis of nitric oxide as measured by the oxidation products nitrite (NO2-) and nitrate (NO3-).	Nitrates	272-279	interferon gamma	Rattus norvegicus	157-166
8674325-8	1996	Children with increased plasma IL-6 concentrations (n = 6) had increased plasma nitrite/nitrate concentrations (p &lt; 0.01 on each day), increased organ failure scores (p &lt; .05 on days 1 and 3), and the highest plasma IL-10 concentrations (p &lt; .05 on days 1 and 3, p = .054 on day 2) when compared with children with sepsis and undetectable IL-6 concentrations.	Nitrates	88-95	interleukin 6	Homo sapiens	31-35
8674325-9	1996	Children with sepsis and detectable IL-6 concentrations, and children with undetectable IL-6 concentrations, both had increased nitrite/nitrate concentrations (p &lt; .005 on days 1 through 3) and increased IL-10 concentrations (p &lt; .05 on days 1 and 2) compared with controls.	Nitrates	136-143	interleukin 6	Homo sapiens	88-92
8842573-9	1996	The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate.	Nitrates	121-128	interleukin 1 receptor like 1	Homo sapiens	46-68
8842573-9	1996	The subsequent drop in plasma nitrate, with a t1/2 of 451 +/- 42 min, was probably a reflection of the redistribution of nitrate within the body fluids and the renal excretion of nitrate.	Nitrates	121-128	interleukin 1 receptor like 1	Homo sapiens	46-68
8651088-1	1996	Nitrate tolerance has been reported to be reversed by certain types of angiotensin-converting enzyme (ACE) inhibitors.	Nitrates	0-7	angiotensin I converting enzyme	Homo sapiens	71-100
8844437-2	1996	It appears to relax vascular smooth muscle through membrane hyperpolarization via increased transmembrane potassium conductance and, like nitrates, through an increase in intracellular cyclic GMP.	Nitrates	138-146	5'-nucleotidase, cytosolic II	Homo sapiens	192-195
8651088-1	1996	Nitrate tolerance has been reported to be reversed by certain types of angiotensin-converting enzyme (ACE) inhibitors.	Nitrates	0-7	angiotensin I converting enzyme	Homo sapiens	102-105
8651088-8	1996	In conclusion, a single oral administration of the ACE inhibitor alacepril (50mg) elicited beneficial effects against exercise-induced myocardial ischemia in patients with stable effort angina during chronic nitrate treatment.	Nitrates	208-215	angiotensin I converting enzyme	Homo sapiens	51-54
8640982-0	1996	Long-term angiotensin-converting enzyme inhibition with high-dose enalapril retards nitrate tolerance in large epicardial arteries and prevents rebound coronary vasoconstriction in vivo.	Nitrates	84-91	angiotensin I converting enzyme	Homo sapiens	10-39
16535328-9	1996	The positive reaction to nitrate overruled a negative response to oxygen, indicating that nitrate is the principal electron acceptor used by Thioploca spp.	Nitrates	25-32	histocompatibility minor 13	Homo sapiens	151-154
16535328-9	1996	The positive reaction to nitrate overruled a negative response to oxygen, indicating that nitrate is the principal electron acceptor used by Thioploca spp.	Nitrates	90-97	histocompatibility minor 13	Homo sapiens	151-154
8689594-6	1996	Greenfeed often contains high levels of nitrate (NO3-), which is known to impair thyroid gland function.	Nitrates	40-47	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
8640982-13	1996	The present study also favors a combination of nitroglycerin and ACE inhibitors to maintain nitrate sensitivity of the vasculature during long-term nitroglycerin treatment.	Nitrates	92-99	angiotensin I converting enzyme	Homo sapiens	65-68
8638526-7	1996	Recent information suggests that nitrate tolerance is caused by increased levels of superoxide at the vascular wall, which leads to reduced nitric oxide level and to increased sensitivity to vasoconstrictive mechanisms, such as endothelin and angiotensin II.	Nitrates	33-40	angiotensinogen	Homo sapiens	228-257
8854644-14	1996	Subcutaneous IL-2 treatment strongly induced nitric oxide synthesis (up to 3.5 mumoles of urinary nitrate/ mouse/day).	Nitrates	98-105	interleukin 2	Mus musculus	13-17
8761850-7	1996	In both nitrate-tolerant and nontolerant coronary arteries, glibenclamide (GLI 10(-6) M), a selective KATP channel blocker, caused a parallel rightward shift in the concentration-response curve to cromakalim, but had no effect on responses to NTG or SNP.	Nitrates	8-15	GLI family zinc finger 1	Homo sapiens	75-78
8761850-8	1996	In nontolerant coronary arteries, GLI had no effect on NIC-induced relaxation, but in nitrate-tolerant preparations, GLI produced a significant rightward shift in the NIC concentration-response curve.	Nitrates	86-93	GLI family zinc finger 1	Homo sapiens	117-120
8928839-2	1996	The infusion of myoglobin (375 mg/kg) resulted in a decrease in renal blood flow, an increase in renal vascular resistance, and a decrease in creatine clearance associated with a decrease in urinary excretory rate of nitrite/nitrate and guanosine 3",5"-cyclic monophosphate (cGMP).	Nitrates	225-232	LOW QUALITY PROTEIN: myoglobin	Oryctolagus cuniculus	16-25
8804922-3	1996	Following injection of endotoxin (bacterial lipopolysaccharide) in rats we detected increased inducible NO synthase mRNA levels in the left ventricular wall within 30 min which then peaked at 3 h. This was followed by an increase in myocardial inducible NO synthase enzyme activity and plasma levels of NO metabolites, nitrate and nitrite, which peaked at 6 and 12 h, respectively.	Nitrates	319-326	nitric oxide synthase 2	Rattus norvegicus	94-115
8620596-6	1996	iNOS mRNA was expressed in the allograft heart and native lung and was associated with increased serum nitrite/nitrate levels.	Nitrates	111-118	nitric oxide synthase 2	Rattus norvegicus	0-4
16535314-5	1996	Nitrate inhibited As(V) reduction by its action as a preferred respiratory electron acceptor rather than as a structural analog of As(V).	Nitrates	0-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-23
16535314-5	1996	Nitrate inhibited As(V) reduction by its action as a preferred respiratory electron acceptor rather than as a structural analog of As(V).	Nitrates	0-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	131-136
16535314-6	1996	Nitrate-respiring sediments could reduce As(V) to As(III) once all the nitrate was removed.	Nitrates	0-7	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
16535314-6	1996	Nitrate-respiring sediments could reduce As(V) to As(III) once all the nitrate was removed.	Nitrates	71-78	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
16535314-7	1996	Chloramphenicol blocked the reduction of As(V) to As(III) in nitrate-respiring sediments, suggesting that nitrate and arsenate were reduced by separate enzyme systems.	Nitrates	61-68	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
16535314-7	1996	Chloramphenicol blocked the reduction of As(V) to As(III) in nitrate-respiring sediments, suggesting that nitrate and arsenate were reduced by separate enzyme systems.	Nitrates	106-113	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	41-46
8620596-7	1996	iNOS inhibition with aminoguanidine prevented or attenuated allograft heart and systemic vascular barrier dysfunction and reduced allograft serum nitrite/nitrate levels to isograft values.	Nitrates	154-161	nitric oxide synthase 2	Rattus norvegicus	0-4
8630708-9	1996	ANP was higher in subjects with jugular venous pressure &gt; 10 cm, presence of a third heart sound, peripheral edema, artificial cardiac pacemaker, atrial arrhythmias, and in those taking digoxin, diuretics, or nitrates.	Nitrates	212-220	natriuretic peptide A	Homo sapiens	0-3
8743440-0	1996	Nitrate contamination of drinking water: relationship with HPRT variant frequency in lymphocyte DNA and urinary excretion of N-nitrosamines.	Nitrates	0-7	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	59-63
8743440-10	1996	In conclusion, consumption of drinking water, especially well water, with high nitrate levels can imply a genotoxic risk for humans as indicated by increased HPRT variant frequencies and by endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite.	Nitrates	79-86	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	158-162
8859948-1	1996	Whether the arterial elastic structures are involved in the beneficial effects of long-term treatment with organic nitrates on atherosclerosis-induced changes in hemodynamics and arterial wall viscoelastic properties, are case for angiotensin-converting enzyme (ACE) inhibitors, is not known.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	231-260
8859948-1	1996	Whether the arterial elastic structures are involved in the beneficial effects of long-term treatment with organic nitrates on atherosclerosis-induced changes in hemodynamics and arterial wall viscoelastic properties, are case for angiotensin-converting enzyme (ACE) inhibitors, is not known.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	262-265
8621213-3	1996	Therefore, we designed these studies to test the hypothesis that Ang II exerts time-dependent effects on renal NO generation as assessed from renal excretion of nitrate and nitrite, percent increases in renal vascular resistance during inhibition of NO synthase with intravenous NG -nitro-L-arginine methyl ester (L-NAME), or decreases in renal vascular resistance during stimulation of endothelial NO synthase with intravenous acetylcholine.	Nitrates	161-168	angiotensinogen	Rattus norvegicus	65-71
8621213-6	1996	The renal excretion of nitrate and nitrite was increased during short-term Ang II infusions (from 205 +/- 22 to 331 +/- 58 pmol.min-1, P &lt; .05) but was unchanged during prolonged Ang II infusion (control group, 197 +/- 33 versus Ang II, 245 +/- 42 pmol.min-1, P=NS).	Nitrates	23-30	angiotensinogen	Rattus norvegicus	75-81
8630708-10	1996	On multivariate analysis independent predictors of ANP levels were, in descending order, nitrates, age, diuretics, and atrial arrhythmias.	Nitrates	89-97	natriuretic peptide A	Homo sapiens	51-54
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Nitrates	79-86	aconitase 1	Homo sapiens	145-186
8871401-2	1996	Here, we focus on two proteins that contain iron-sulfur clusters, the fumarate nitrate reduction (FNR) protein of Escherichia coli and mammalian iron-responsive-element-binding protein 1 (IRP1), both of which function as direct sensors of oxygen and iron levels.	Nitrates	79-86	aconitase 1	Homo sapiens	188-192
12226271-0	1996	Appearance of Novel Glucose-6-Phosphate Dehydrogenase Isoforms in Chlamydomonas reinhardtii during Growth on Nitrate.	Nitrates	109-116	uncharacterized protein	Chlamydomonas reinhardtii	20-53
8627326-0	1996	Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo.	Nitrates	48-55	nitric oxide synthase 2	Homo sapiens	76-97
8627326-1	1996	The ex vivo tissue concentration of nitrite and nitrate (NOx) was found to correlate closely with the activity of nitric oxide synthase (NOS; EC 1.14.13.39) in various brain regions.	Nitrates	48-55	nitric oxide synthase 2	Homo sapiens	114-135
8731510-2	1996	We observed that insulin at concentration in the range 0.25-2 nmol/L decreases platelet response to adenosine 5-diphosphate (ADP), being Effective Dose 50 (ED50) for ADP with 2 nmol/L insulin 164 +/- 15% of the basal value, p = 0.005; furthermore, insulin increases intraplatelet content of cGMP (from basal 7.3 +/-0.6 pmol/10(9) plts to 14.6 +/- 1.2 pmol/10(9) plts with 2 nmol/L insulin, p=0.0001) and does not affect the platelet cGMP increase induced by nitrates.	Nitrates	458-466	insulin	Homo sapiens	17-24
8731510-3	1996	On the contrary, at very elevated concentrations (25-200 nmol/L) insulin increases platelet aggregation to ADP (ADP ED50 with 200 nmol/L insulin being 81 +/- 4% of the basal value, p = 0.01), decreases intraplatelet content of cGMP (from basal 7.2 +/- 0.1 pmol/10(9) plts to 5.7 +/- 0.2 pmol/10(9) plts with 200 nmol/L insulin, p = 0.01) and attenuates the platelet cGMP increase induced by nitrates.	Nitrates	391-399	insulin	Homo sapiens	65-72
8661258-1	1996	Gd3+ is shown to be an effective shift reagent for 14N and 15N nitrate NMR signals, resolving the internal and external nitrate signals in plant tissues, including cell suspensions and root material.	Nitrates	63-70	GRDX	Homo sapiens	0-3
8661258-1	1996	Gd3+ is shown to be an effective shift reagent for 14N and 15N nitrate NMR signals, resolving the internal and external nitrate signals in plant tissues, including cell suspensions and root material.	Nitrates	120-127	GRDX	Homo sapiens	0-3
8661258-2	1996	However, time-course experiments show that, while the use of Gd3+ allows nitrate levels to be monitored over extended periods, it also has adverse effects on growth and nitrate uptake.	Nitrates	73-80	GRDX	Homo sapiens	61-64
8661258-2	1996	However, time-course experiments show that, while the use of Gd3+ allows nitrate levels to be monitored over extended periods, it also has adverse effects on growth and nitrate uptake.	Nitrates	169-176	GRDX	Homo sapiens	61-64
8904084-2	1996	Interleukin-1beta stimulated the production of nitrite and nitrate, stable metabolites of NO, in a dose- and time-dependent manner in vascular smooth muscle cells.	Nitrates	59-66	interleukin 1 beta	Rattus norvegicus	0-17
8628918-11	1996	Several cases of methemoglobinemia have been reported in infants in the United States using water containing nitrate at levels higher than the current maximum contaminant level (MCL) of 45 ppm (mg/liter) nitrate (NO3) or 10 ppm nitrate-nitrogen (nitrate-N), but none at or lower than the MCL.	Nitrates	109-116	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
8741130-2	1996	Recently, it has been reported decreased CSF nitrate levels (oxidation product that provides an indirect estimation of nitric oxide) in Parkinson"s disease patients, assessed with a colorimetric method.	Nitrates	45-52	colony stimulating factor 2	Homo sapiens	41-44
8741130-5	1996	They were not influenced significantly by antiparkinsonian drugs in patients, although there was a trend for CSF nitrate levels to be higher in patients treated with levodopa or with dopamine agonists.	Nitrates	113-120	colony stimulating factor 2	Homo sapiens	109-112
8628918-11	1996	Several cases of methemoglobinemia have been reported in infants in the United States using water containing nitrate at levels higher than the current maximum contaminant level (MCL) of 45 ppm (mg/liter) nitrate (NO3) or 10 ppm nitrate-nitrogen (nitrate-N), but none at or lower than the MCL.	Nitrates	204-211	NBL1, DAN family BMP antagonist	Homo sapiens	213-216
8924591-13	1996	The most important variables, associated with both mutagenicity and Ah receptor affinity, included 1-nitropyrene, particle bound nitrate, indeno[1,2,3-cd]pyrene, and emitted mass of particles.	Nitrates	129-136	aryl hydrocarbon receptor	Homo sapiens	68-79
8647309-9	1996	The nitrate levels were in the range 1-2.6 mg/kg NO3- for fresh milk and 1.1-18 mg/kg NO3- for dry milk.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	49-52
8739090-1	1996	The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine.	Nitrates	31-38	NBL1, DAN family BMP antagonist	Homo sapiens	40-43
8569419-3	1996	Thus we studied sex differences in NO-generation by measuring single breath NO-exhalation and plasma levels of nitrate (NO3), the stable endmetabolite of NO.	Nitrates	111-118	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
8598489-0	1996	IL-1 beta does not cause neutrophil degranulation but does lead to IL-6, IL-8, and nitrite/nitrate release when used in patients with cancer.	Nitrates	91-98	interleukin 1 beta	Homo sapiens	0-9
8632501-1	1996	BACKGROUND: Hexogen (cyclonite, RDX) nitrate explosive is an infrequent cause of poisoning.	Nitrates	37-44	radixin	Homo sapiens	32-35
8754362-9	1996	For patients who cannot take an ACE inhibitor the combination of hydralazine and nitrates may offer some prognostic benefit.	Nitrates	81-89	angiotensin I converting enzyme	Homo sapiens	32-35
7489995-4	1995	Pretreatment of mice with IL-1 resulted in elevated levels of nitrite/nitrate in serum and in enhanced nitric oxide synthase (NOS) activity in liver cells isolated from these animals.	Nitrates	70-77	interleukin 1 complex	Mus musculus	26-30
8878363-3	1996	The chemical analysis of fog during 32 episodes of local fog (pH, chloride, nitrate, sulphate, sodium, ammonia, potassium, magnesium, calcium) has shown a greater concentration of pollutants and greater acidity in the smaller particles (2-6 microns) which are able to penetrate the bronchial tree.	Nitrates	76-83	zinc finger protein, FOG family member 1	Homo sapiens	25-28
7594544-6	1995	Increased levels of nitrate (NO3-) were only detected in serum of resistant C57BL/6 mice at the time of peak parasitemia.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Mus musculus	29-32
8616217-10	1995	The striking degree of conservation between the macrophage-specific mammalian Nramp and its OsNramp1 plant homologue is discussed with respect to possible implications in the metabolism of nitrate in both organisms.	Nitrates	189-196	solute carrier family 11 member 1	Homo sapiens	78-83
7492033-10	1995	For the Indonesian dry (powdered) milk sample studied the nitrate levels were in the range 10.7-29.5 mg kg-1 NO3-.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	109-112
8597057-2	1995	Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity.	Nitrates	91-98	interleukin 1 beta	Mus musculus	26-44
8597057-2	1995	Pretreatment of mice with interleukin-1 beta (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity.	Nitrates	91-98	interleukin 1 complex	Mus musculus	46-50
8534848-6	1995	They were designated as iNR1 and iNR2, respectively, since both were inducible by nitrate.	Nitrates	82-89	inducible nitrate reductase [NADH] 1	Glycine max	24-28
7594598-18	1995	Subcutaneous IL-2 therapy increased urinary nitrate excretion up to eightfold in mice, and appeared to produce a significant survival advantage that was prevented by MLA administration.	Nitrates	44-51	interleukin 2	Mus musculus	13-17
8747803-13	1995	N-acetylcysteine inhibits angiotensin converting enzyme and counteracts nitrate-induced stimulation of the renin angiotensin system in vivo.	Nitrates	72-79	renin	Homo sapiens	107-112
8747803-17	1995	Thus, administration of NAC may change the normal vasodilator profile of nitrates.	Nitrates	73-81	synuclein alpha	Homo sapiens	24-27
8534848-6	1995	They were designated as iNR1 and iNR2, respectively, since both were inducible by nitrate.	Nitrates	82-89	inducible nitrate reductase [NADH] 2	Glycine max	33-37
8534848-16	1995	In northern blots, the steady-state level of iNR1 mRNA was similar for the nr1 mutant and the wild-type parent after 20 to 48 h induction by nitrate.	Nitrates	141-148	inducible nitrate reductase [NADH] 1	Glycine max	45-49
8534848-16	1995	In northern blots, the steady-state level of iNR1 mRNA was similar for the nr1 mutant and the wild-type parent after 20 to 48 h induction by nitrate.	Nitrates	141-148	LOC100037451	Glycine max	75-78
7483050-8	1995	Ongoing treatment with diuretics did not seem to be a risk factor for developing reduced kidney function, whereas significantly more patients on treatment with nitrates, indicating generalised atherosclerosis, developed reduced kidney function during treatment with ACE-inhibitors.	Nitrates	160-168	angiotensin I converting enzyme	Homo sapiens	266-269
7545539-10	1995	Oral administration of N-monomethyl-L-arginine, an inhibitor of nitric oxide synthase (NOS), reduced urinary nitrate excretion and also the severity of myositis.	Nitrates	109-116	nitric oxide synthase 1, neuronal	Mus musculus	64-85
7561687-10	1995	Similarly, 4% of the embryos from pregnant CD1 mice on days 8 and 12 of gestation produced a significant amount of nitrate, which again correlated with the low incidence of resorption observed in these mice.	Nitrates	115-122	CD1 antigen complex	Mus musculus	43-46
8556991-4	1995	However, LPS combined with either EGF or PDGF caused a significant increase in nitrite/nitrate concentration relative to LPS alone and growth factor alone.	Nitrates	87-94	epidermal growth factor like 1	Rattus norvegicus	34-37
8556991-5	1995	The highest level level of nitrite/nitrate concentration was observed with the triple combination of LPS, EGF, and PDGF.	Nitrates	35-42	epidermal growth factor like 1	Rattus norvegicus	106-109
7674685-7	1995	Nitrates are highly effective antianginal drugs with complex beneficial actions in patients with CAD, but their usefulness is limited by development of tolerance during long-term use.	Nitrates	0-8	aconitate decarboxylase 1	Homo sapiens	97-100
7565593-2	1995	To check whether Nii host genes and transgenes (encoding nitrite reductase, the second enzyme of the nitrate assimilation pathway) were also susceptible to silencing, a transgene consisting of the tobacco Nii1 gene with two copies of the enhancer of the 35S promoter cloned 1 kb upstream of the Nii promoter region was introduced into tobacco plants.	Nitrates	101-108	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	57-74
7643383-0	1995	Nitrate and nitrite regulation of the Fnr-dependent aeg-46.5 promoter of Escherichia coli K-12 is mediated by competition between homologous response regulators (NarL and NarP) for a common DNA-binding site.	Nitrates	0-7	neuronal pentraxin 2	Homo sapiens	171-175
7643383-1	1995	The NarL and NarP proteins are homologous response regulators that function to regulate anaerobic respiratory gene expression in response to nitrate and nitrite in Escherichia coli.	Nitrates	141-148	neuronal pentraxin 2	Homo sapiens	13-17
7643383-12	1995	Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro.	Nitrates	84-91	neuronal pentraxin 2	Homo sapiens	185-189
7643383-3	1995	aeg-46.5 operon expression is further induced by the NarP protein in response to nitrate or nitrite and this induction is antagonized by NarL.	Nitrates	81-88	neuronal pentraxin 2	Homo sapiens	53-57
7643383-12	1995	Single and double nucleotide substitutions in the -44.5 region reduced or abolished nitrate and nitrite induction of aeg-46.5 operon expression in vivo and prevented the binding of MBP-NarP and MBP-NarL to the control region in vitro.	Nitrates	84-91	myelin basic protein	Homo sapiens	194-197
7643383-13	1995	Presumably, the NarP and NarL proteins compete for the -44.5 binding site to regulate aeg-46.5 operon expression in response to nitrate and nitrite.	Nitrates	128-135	neuronal pentraxin 2	Homo sapiens	16-20
7621816-7	1995	Based on its phenotype and expression pattern as well as its structural similarities to NRAMPs and a nitrate transporter in Aspergillus nidulans, we discuss a possible role for MVL in nitrite/nitrate transport and its implications.	Nitrates	101-108	Malvolio	Drosophila melanogaster	177-180
7539147-5	1995	Paradoxically, constrictions caused by endothelin 1 were decreased in nitrate-tolerant vessels.	Nitrates	70-77	endothelin-1	Oryctolagus cuniculus	39-51
7590863-4	1995	In sera of patients, nitrite plus nitrate levels correlated significantly with neopterin, soluble tumor necrosis factor receptor 55 and 75, and beta 2-microglobulin.	Nitrates	34-41	beta-2-microglobulin	Homo sapiens	144-164
7670778-4	1995	The nitrate serum levels correlated closely with CRP and ESR (r = 0.8, P &lt; 0.001, each).	Nitrates	4-11	C-reactive protein	Homo sapiens	49-52
7478791-2	1995	The terminal guanidino N-atom of L-arginine is the precursor for NO, which is oxidized to the stable inorganic nitrogen oxides, nitrite (NO2-) and nitrate (NO3-).	Nitrates	147-154	NBL1, DAN family BMP antagonist	Homo sapiens	156-159
7539147-8	1995	We propose that increased autocrine production of endothelin 1 in nitrate tolerance sensitizes vascular smooth muscle to a variety of vasoconstrictors through a protein kinase C-mediated mechanism.	Nitrates	66-73	endothelin-1	Oryctolagus cuniculus	50-62
8630818-1	1995	The studies made showed that repeated combined action of chemical factors (pesticides of different chemical groups, Cd and Pb salts, nitrates) in the doses studied resulted in an increase of the lipid peroxidation (LPO) in tissues, accumulation of its end products in biosubstrates, and activation of catalase and peroxidase oxidoreductases in blood of test animals.	Nitrates	133-141	catalase	Homo sapiens	301-309
7537701-3	1995	Here we demonstrate that injection of endotoxin into rats leads to the expression of an inducible isoform of .NO synthase (iNOS) in the thoracic aorta at 6 h and an increase in the circulating levels of nitrite/nitrate.	Nitrates	211-218	nitric oxide synthase 2	Rattus norvegicus	123-127
7565112-8	1995	Therefore, expression of nuo is regulated by O2 and nitrate via ArcA, NarL, FNR and IHF at sites within the -277 region, and by other factors including C4 dicarboxylates at a site between -277 and -899.	Nitrates	52-59	arginine deiminase	Escherichia coli	64-68
7536714-2	1995	A combination of interleukin-1 alpha (100 U/mL) and tumor necrosis factor--alpha (5000 U/mL) induced accumulation of nitrite/nitrate, the stable end products of nitric oxide, in culture media within 48 hours.	Nitrates	125-132	tumor necrosis factor	Rattus norvegicus	17-80
7536714-6	1995	Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment.	Nitrates	21-28	tumor necrosis factor	Rattus norvegicus	62-89
7536714-6	1995	Induction of nitrite/nitrate production by the combination of tumor necrosis factor-alpha and bacterial lipopolysaccharide or that of interleukin-1 alpha and interferon gamma (100 U/mL) was also inhibited by cyclosporin A cotreatment.	Nitrates	21-28	interleukin 1 alpha	Rattus norvegicus	134-153
12228402-6	1995	In vivo labeling of wheat-leaf PEPC by feeding 32P-labeled orthophosphate showed that PEPC from light plus KNO3 tissue was substantially more phosphorylated than the enzyme in the dark minus-nitrate immunoprecipitates.	Nitrates	191-198	phosphoenolpyruvate carboxylase 2	Triticum aestivum	31-35
12228402-6	1995	In vivo labeling of wheat-leaf PEPC by feeding 32P-labeled orthophosphate showed that PEPC from light plus KNO3 tissue was substantially more phosphorylated than the enzyme in the dark minus-nitrate immunoprecipitates.	Nitrates	191-198	phosphoenolpyruvate carboxylase 2	Triticum aestivum	86-90
7810695-6	1994	Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions.	Nitrates	199-206	renin	Rattus norvegicus	14-19
7716247-9	1995	Experiments carried out with detached leaves revealed an influence of light, nitrate, and sucrose on icdh-1 transcript levels and in some cases also on NADP(+)-dependent ICDH activity.	Nitrates	77-84	isocitrate dehydrogenase [NADP]	Solanum tuberosum	101-107
7716247-10	1995	In darkness, nitrate or sucrose induced icdh-1 mRNA expression.	Nitrates	13-20	isocitrate dehydrogenase [NADP]	Solanum tuberosum	40-46
7596294-1	1995	The expression of the structural genes nit-3 and nit-6, which encode the nitrate assimilatory enzymes nitrate reductase and nitrite reductase, respectively, is highly regulated by the global-acting NIT2 regulatory protein.	Nitrates	73-80	nitrilase family member 2	Homo sapiens	198-202
7539338-10	1995	Using previously published data, we developed a pharmacokinetic-pharmacodynamic model that relates the production of TNF in response to administration of FAA, the enhancement of NOS activity in response to TNF, and the elevation of plasma nitrate in response to NO production.	Nitrates	239-246	tumor necrosis factor	Mus musculus	117-120
8839229-13	1995	The development of ITF 296 as a new orally active nitrate is supported by its pharmacokinetic profile in rats and dogs.	Nitrates	50-57	trefoil factor 3	Rattus norvegicus	19-22
7810695-6	1994	Activation of renin secretion by isethionate and acetate was blunted with 100 pmol/l angiotensin II (ANG II), whereas tenfold higher concentrations of ANG II were required to attenuate the effect of nitrate ions.	Nitrates	199-206	angiotensinogen	Rattus norvegicus	151-157
7810695-7	1994	The amount of renin released in the presence of nitrate was fully additive to RSR values obtained with maximally effective doses of isoproterenol.	Nitrates	48-55	renin	Rattus norvegicus	14-19
7810695-9	1994	The stimulatory influence of membrane-permeable nitrate anions appears to involve additional pathways and is mediated by a decreased calcium sensitivity of the renin secretory process rather than resulting from an adenosine 3",5"-cyclic monophosphate-dependent action.	Nitrates	48-55	renin	Rattus norvegicus	160-165
7523451-3	1994	Treatment with IL-1 beta resulted in a marked increase in media nitrite and nitrate accumulation, morphological alterations, and increased release of lactate dehydrogenase (LDH) into media.	Nitrates	76-83	interleukin 1 beta	Rattus norvegicus	15-24
24306501-7	1994	Feeding nitrate to excised leaves of nitrogen deficient plants enhanced the degree of light activation of PEP carboxylase in the C4 species maize, but had little or no effect in the C3 species wheat.	Nitrates	8-15	phosphoenolpyruvate carboxylase 2	Zea mays	106-109
7523382-3	1994	The NO metabolites nitrite and nitrate rose &gt; 10-fold in medium from stimulated versus unstimulated cells over 24 h. Concomitant with elevated nitrogen oxides, Egr-1 mRNA levels declined to 80% below unstimulated cells at 24 h. This decline was blocked by an inhibitor of NO production, NG-monomethyl-L-arginine.	Nitrates	31-38	early growth response 1	Rattus norvegicus	163-168
7743368-2	1994	In this pilot study, we wanted to know if the serum values of nitrite/nitrate (NO2/NO3), the stable endproducts of NO biosynthesis, are elevated in patients with septic shock.	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	83-86
7927208-6	1994	Polyclonal rabbit anti-mouse anti-tumor necrosis factor-alpha reduced in vivo tumor necrosis factor-alpha levels (1 hr, 7,332 +/- 1,492 U tumor necrosis factor-alpha per milliliter) and reduced nitric oxide synthesis as measured by plasma nitrite and nitrate (352 +/- 69 mumol/L).	Nitrates	251-258	tumor necrosis factor	Mus musculus	34-61
7991680-1	1994	Nitrate reductase (NR) is the first enzyme in nitrate assimilation, a critical process for plant survival.	Nitrates	46-53	nitrate reductase 1	Arabidopsis thaliana	0-17
7991680-1	1994	Nitrate reductase (NR) is the first enzyme in nitrate assimilation, a critical process for plant survival.	Nitrates	46-53	nitrate reductase 1	Arabidopsis thaliana	19-21
7991680-4	1994	We are interested in understanding the mechanism of nitrate induction of higher plant NR genes.	Nitrates	52-59	nitrate reductase 1	Arabidopsis thaliana	86-88
7991680-5	1994	Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression.	Nitrates	120-127	nitrate reductase 1	Arabidopsis thaliana	81-83
7991680-5	1994	Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression.	Nitrates	120-127	nitrate reductase 1	Arabidopsis thaliana	91-94
7991680-5	1994	Here we describe promoter analyses of the 5" flanking regions of the Arabidopsis NR genes, NR1 and NR2, with respect to nitrate induction of gene expression.	Nitrates	120-127	nitrate reductase 2	Arabidopsis thaliana	99-102
7991680-8	1994	Deletion analyses of these regions show that 238- and 188-bp 5" flanking regions of the NR1 and NR2, respectively, contain sequences responsive to nitrate induction.	Nitrates	147-154	nitrate reductase 1	Arabidopsis thaliana	88-91
7991680-8	1994	Deletion analyses of these regions show that 238- and 188-bp 5" flanking regions of the NR1 and NR2, respectively, contain sequences responsive to nitrate induction.	Nitrates	147-154	nitrate reductase 2	Arabidopsis thaliana	96-99
8182055-1	1994	Nitrate reductase (NR), the first enzyme in the nitrate assimilation pathway, is regulated post-transcriptionally in response to light and CO2.	Nitrates	48-55	nitrate reductase 1	Arabidopsis thaliana	0-17
7919993-7	1994	At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport.	Nitrates	123-130	nitrate transporter 1.1	Arabidopsis thaliana	162-166
7919993-7	1994	At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport.	Nitrates	123-130	solute carrier family 15 member 1	Oryctolagus cuniculus	222-227
7919993-7	1994	At the amino acid level, the Arabidopsis plant peptide transporter shows 24.6, 28.5, and 45.2% identity to the Arabidopsis nitrate-inducible nitrate transporter (CHL1), the rabbit small intestine oligopeptide transporter (PepT1), and the yeast peptide transporter (Ptr2p), respectively, but little identity to other proteins known to be involved in peptide transport.	Nitrates	123-130	Ptr2p	Saccharomyces cerevisiae S288C	265-270
7867440-3	1994	However, when captopril (CPT, 12.5-25mg, 3 times daily) was combined with nitrates, the clinical effects were enhanced and maintained throughout the study, along with a decrease in the level of AII and body weight.	Nitrates	74-82	angiotensinogen	Homo sapiens	194-197
8066882-3	1994	The nitrates are inactive prodrugs, and their vascular effects depend on metabolic conversion to vasoactive intermediates like nitric oxide and/or nitrosothiols with subsequent stimulation of guanylate cyclase causing increased formation of cyclic GMP.	Nitrates	4-12	5'-nucleotidase, cytosolic II	Homo sapiens	248-251
7812715-2	1994	The first step of the pathway, the reduction of nitrate to nitrite, is catalyzed by nitrate reductase, a multi-redox cofactor enzyme which belongs to the class of flavoprotein pyridine nucleotide cytochrome reductases.	Nitrates	48-55	nitrate reductase [NADH] 1	Zea mays	84-101
8033999-4	1994	In addition to members of the AAP gene family, an integral membrane protein (NTR1) that shows significant similarities to the low affinity nitrate transporter from Arabidpsis and to peptide transporters from yeast and rabbit was identified.	Nitrates	139-146	mRNA splicing protein SPP382	Saccharomyces cerevisiae S288C	77-81
8182055-1	1994	Nitrate reductase (NR), the first enzyme in the nitrate assimilation pathway, is regulated post-transcriptionally in response to light and CO2.	Nitrates	48-55	nitrate reductase 1	Arabidopsis thaliana	19-21
8209223-5	1994	Nitrate levels of &gt; 45 mg l-1 were observed in 8% of the well samples in 1989 and 5% of them showed the presence of both elevated levels of nitrate and faecal coliforms.	Nitrates	0-7	immunoglobulin kappa variable 1-16	Homo sapiens	29-32
8180640-8	1994	CONCLUSIONS: A controlled clinical trial is needed to clarify how consuming high-nitrate foods correlates with methemoglobin levels in infants younger than 6 months.	Nitrates	81-88	hemoglobin subunit gamma 2	Homo sapiens	111-124
7508388-2	1994	Nitric oxide (NO) reductase is an integral membrane component of the anaerobic respiratory chain of Pseudomonas stutzeri that transforms nitrate to dinitrogen (denitrification).	Nitrates	137-144	cbb3-type cytochrome c oxidase subunit I	Pseudomonas stutzeri	0-27
7914830-1	1994	As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates.	Nitrates	235-243	alpha hemoglobin stabilizing protein	Homo sapiens	84-119
7914830-1	1994	As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates.	Nitrates	235-243	alpha hemoglobin stabilizing protein	Homo sapiens	121-125
7914830-1	1994	As a result of recent advances in our understanding of the role of nitric oxide and endothelial-derived relaxing factor (EDRF) in vascular control, physicians now have the potential to overcome the loss of EDRF effect by administering nitrates.	Nitrates	235-243	alpha hemoglobin stabilizing protein	Homo sapiens	206-210
8180624-1	1994	The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport.	Nitrates	80-87	uncharacterized protein	Chlamydomonas reinhardtii	48-53
7507509-3	1994	MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains.	Nitrates	47-54	Fas (TNF receptor superfamily member 6)	Mus musculus	4-7
7507509-3	1994	MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains.	Nitrates	47-54	Fas (TNF receptor superfamily member 6)	Mus musculus	8-11
7507509-3	1994	MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains.	Nitrates	47-54	Fas (TNF receptor superfamily member 6)	Mus musculus	8-11
7507509-3	1994	MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) than did mice of normal strains and MRL-(+/+) and B6-lpr/lpr congenic strains.	Nitrates	47-54	Fas (TNF receptor superfamily member 6)	Mus musculus	8-11
8184893-7	1994	Similarly, iodide and nitrate stimulated renin release.	Nitrates	22-29	renin	Rattus norvegicus	41-46
8132465-7	1994	Results presented here indicate that the increase of sdh and lct expression by nitrate depended on its chemical reduction, which in turn diminished the ArcA-P pool.	Nitrates	79-86	arginine deiminase	Escherichia coli	152-156
8180624-1	1994	The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport.	Nitrates	80-87	uncharacterized protein	Chlamydomonas reinhardtii	160-165
8180624-1	1994	The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport.	Nitrates	126-133	uncharacterized protein	Chlamydomonas reinhardtii	48-53
8180624-1	1994	The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport.	Nitrates	126-133	uncharacterized protein	Chlamydomonas reinhardtii	160-165
8180624-3	1994	Their nitrate non-utilizing phenotype has been directly complemented by transformation using the pCO-5 plasmid which carries the nar-2, nar-3, and nar-4 clustered genes.	Nitrates	6-13	uncharacterized protein	Chlamydomonas reinhardtii	147-152
8180624-5	1994	Complementation of the nitrate non-utilizing phenotype of the constructed strains was also achieved by co-transformation with plasmids containing nar-2 and nar-3 genes or nar-2 and nar-4, but not with single plasmids containing each individual gene.	Nitrates	23-30	uncharacterized protein	Chlamydomonas reinhardtii	181-186
7508220-5	1994	Hepatocyte iNOS messenger RNA (mRNA) levels were correlated with iNOS activity and circulating plasma nitrite and nitrate levels.	Nitrates	114-121	nitric oxide synthase 2	Rattus norvegicus	11-15
8087822-3	1994	However, nitrates also exhibit platelet-inhibiting properties, mediated by the same cellular mechanisms operating on smooth muscle cells, i.e., via stimulation of guanylate cyclase and subsequent increase in cytosolic levels of cyclic GMP.	Nitrates	9-17	5'-nucleotidase, cytosolic II	Homo sapiens	235-238
8185875-6	1994	The principle component of the coating is nitrite ion, which in the presence of ozone is oxidized to nitrate ion on the filter medium (NO2- + O3 produces NO3- + O2).	Nitrates	101-108	NBL1, DAN family BMP antagonist	Homo sapiens	154-157
8113156-6	1994	Both nitrates and nifedipine induced a significant decrease in DR1/3 (indicating an increase in left ventricular ejection flow) in relation to a reduction of the reflected pressure wave.	Nitrates	5-13	down-regulator of transcription 1	Homo sapiens	63-68
8111016-2	1994	In ammonium-grown wild-type cells, nit-1 (nitrate reductase, NR), nar-1, nar-2 and nar-3 (nitrate transporter) genes showed very similar kinetics of expression when transferred to nitrate medium.	Nitrates	42-49	uncharacterized protein	Chlamydomonas reinhardtii	35-40
8111016-5	1994	In contrast to the other nar transcripts, that nar-4, a gene sharing similar sequences with nar-3, accumulated in small amounts in wild-type cells, and only increased after a long nitrate induction period.	Nitrates	180-187	uncharacterized protein	Chlamydomonas reinhardtii	47-52
16349084-12	1993	Ectocellular aminopeptidase may be common in marine synechococci and play roles in their nitrogen nutrition, particularly in low-nitrate and low-light environments.	Nitrates	129-136	carboxypeptidase Q	Homo sapiens	13-27
7509009-2	1993	The combination of interferon-gamma (100 U/ml) and tumor necrosis factor-alpha (5000 U/ml) evoked a time-dependent increase in nitric oxide synthase mRNA and nitrite/nitrate production, both of which were inhibited by dexamethasone.	Nitrates	166-173	tumor necrosis factor	Rattus norvegicus	19-78
8225220-6	1993	High serum nitrite/nitrate levels were associated with high plasma renin activity, high aldosterone and antidiuretic hormone levels and low urinary excretion of sodium.	Nitrates	19-26	renin	Homo sapiens	67-72
8248688-4	1993	In parallel with the discovery of the endothelium-derived relaxing factor (EDRF) and its biochemical identification as nitric oxide (NO), it became clear that organic nitrates act via the release of NO in the vascular wall and thus by using metabolic pathways identical to those of endogenous EDRF.	Nitrates	167-175	alpha hemoglobin stabilizing protein	Homo sapiens	75-79
8286141-3	1993	In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	95-98
8286141-3	1993	In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	316-319
8248688-4	1993	In parallel with the discovery of the endothelium-derived relaxing factor (EDRF) and its biochemical identification as nitric oxide (NO), it became clear that organic nitrates act via the release of NO in the vascular wall and thus by using metabolic pathways identical to those of endogenous EDRF.	Nitrates	167-175	alpha hemoglobin stabilizing protein	Homo sapiens	293-297
8413188-1	1993	Three overlapping clones covering a Chlamydomonas reinhardtii genomic region of about 32 kb appear to contain five genes potentially involved in nitrate assimilation in addition to the nitrate reductase structural locus nit-1.	Nitrates	145-152	uncharacterized protein	Chlamydomonas reinhardtii	185-202
8399219-6	1993	However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK.	Nitrates	50-57	creatine kinase, mitochondrial 2	Gallus gallus	126-132
8399219-6	1993	However, upon addition of MgADP plus creatine and nitrate to induce a transition-state analogue complex of the enzyme, native Mib-CK dissociated much more readily into dimers than proteinase K-digested Mib-CK.	Nitrates	50-57	creatine kinase, mitochondrial 2	Gallus gallus	202-208
8134178-1	1993	In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF).	Nitrates	101-108	tumor necrosis factor-like	Rattus norvegicus	224-245
8134178-1	1993	In a rat model of fatal infection caused by Pseudomonas aeruginosa, the circulating level of nitrite/nitrate (NO2-/NO3-), a good indicator for nitric oxide production, was remarkably increased after elevation of circulatory tumor necrosis factor (TNF).	Nitrates	101-108	tumor necrosis factor-like	Rattus norvegicus	247-250
8413188-1	1993	Three overlapping clones covering a Chlamydomonas reinhardtii genomic region of about 32 kb appear to contain five genes potentially involved in nitrate assimilation in addition to the nitrate reductase structural locus nit-1.	Nitrates	145-152	uncharacterized protein	Chlamydomonas reinhardtii	220-225
8413188-2	1993	These new loci produced transcripts of 2.8, 2.2, 1.8 and 1.7 kb in nitrate-induced wild-type cells that, like the 3.4 kb transcript of nit-1, were undetectable in cells grown in ammonium.	Nitrates	67-74	nitrilase 1	Mus musculus	135-140
8413188-3	1993	In addition, in a mutant defective at the regulatory locus, nit-2 for nitrate assimilation, which does not express the nit-1 gene transcript, accumulation of the four other transcripts was also blocked.	Nitrates	70-77	uncharacterized protein	Chlamydomonas reinhardtii	60-65
8391401-2	1993	BACKGROUND: The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance.	Nitrates	265-272	5'-nucleotidase, cytosolic II	Homo sapiens	97-100
8391783-8	1993	These results suggest that nitrate-stabilized, dead-end complexes of hexokinase may be useful in stabilizing the closed conformation of this "hinge-bending" enzyme for crystallographic experiments.	Nitrates	27-34	hexokinase 1	Homo sapiens	69-79
8368322-4	1993	Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM).	Nitrates	8-15	tumor necrosis factor-like	Rattus norvegicus	215-218
8368322-4	1993	Nitrite/nitrate accumulation was maximal at 72 h, with most of the increase occurring from 48 to 72 h. Maximal nitrite/nitrate production was observed with triple combinations with the combination of LPS, IL-1, and TNF giving the highest concentration (137.4 +/- 2.8 microM).	Nitrates	119-126	tumor necrosis factor-like	Rattus norvegicus	215-218
8391783-2	1993	Nitrate binds to the active site of hexokinase when MnIIADP and a sugar substrate or analogue are present.	Nitrates	0-7	hexokinase 1	Homo sapiens	36-46
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrates	159-166	nitric oxide synthase 2	Rattus norvegicus	0-31
8504586-6	1993	In a canine experimental model of acute regional myocardial necrosis, hypertrophy and dilatation appear to have a different time course, and both may be attenuated by pharmacologic intervention with either an angiotensin-converting enzyme (ACE) inhibitor or a nitrate.	Nitrates	260-267	angiotensin I converting enzyme	Canis lupus familiaris	209-238
8510658-4	1993	Plants in which the NIA2 gene has been deleted retain only 10% of the wild-type shoot NR activity and grow normally with nitrate as the sole nitrogen source.	Nitrates	121-128	nitrate reductase 2	Arabidopsis thaliana	20-24
8510658-6	1993	nia1, nia2 double mutants have only 0.5% of wild-type shoot NR activity and display very poor growth on media with nitrate as the only form of nitrogen.	Nitrates	115-122	nitrate reductase 1	Arabidopsis thaliana	0-4
8510658-6	1993	nia1, nia2 double mutants have only 0.5% of wild-type shoot NR activity and display very poor growth on media with nitrate as the only form of nitrogen.	Nitrates	115-122	nitrate reductase 2	Arabidopsis thaliana	6-10
8510658-8	1993	These results show that the NIA1 gene encodes a functional NR protein that contributes to the assimilation of nitrate in Arabidopsis.	Nitrates	110-117	nitrate reductase 1	Arabidopsis thaliana	28-32
8510658-8	1993	These results show that the NIA1 gene encodes a functional NR protein that contributes to the assimilation of nitrate in Arabidopsis.	Nitrates	110-117	nitrate reductase 1	Arabidopsis thaliana	59-61
8394263-1	1993	Genetic evidence suggests that the NIT2 gene of Chlamydomonas reinhardtii encodes a positive regulator of the nitrate-assimilation pathway.	Nitrates	110-117	uncharacterized protein	Chlamydomonas reinhardtii	35-39
8394263-9	1993	These results suggest that repression of the NIT2 gene may mediate metabolite repression of the nitrate assimilation pathway in Chlamydomonas.	Nitrates	96-103	uncharacterized protein	Chlamydomonas reinhardtii	45-49
8389858-1	1993	Nitrate tolerance has been explained by 1) a direct loss of pharmacological effect due to reduced bioconversion and 2) an indirect effect due to activation of the renin/angiotensin system and counter-regulatory vasoconstriction.	Nitrates	0-7	renin	Rattus norvegicus	163-168
7682068-3	1993	Inducible nitric oxide synthase (iNOS) activity was determined by measuring the stable nitrogen oxide end products of L-arginine oxidation: nitrite (NO2-) and nitrate (NO3-).	Nitrates	159-166	nitric oxide synthase 2	Rattus norvegicus	33-37
8483458-4	1993	Some of these nit-1 or nit-2 mutants were also defective in pathways not directly related to nitrate assimilation, such as those of amino acids and purines.	Nitrates	93-100	uncharacterized protein	Chlamydomonas reinhardtii	14-19
8453665-2	1993	The CHL1 gene of Arabidopsis, which when mutated confers resistance to the herbicide chlorate and a decrease in nitrate uptake, was isolated and found to encode a protein with 12 putative membrane-spanning segments.	Nitrates	112-119	nitrate transporter 1.1	Arabidopsis thaliana	4-8
8453665-3	1993	Injection of CHL1 mRNA into Xenopus oocytes produces a nitrate- and pH-dependent membrane depolarization, inward current, and nitrate uptake.	Nitrates	55-62	DEAD/H-box helicase 11 L homeolog	Xenopus laevis	13-17
8453665-3	1993	Injection of CHL1 mRNA into Xenopus oocytes produces a nitrate- and pH-dependent membrane depolarization, inward current, and nitrate uptake.	Nitrates	126-133	DEAD/H-box helicase 11 L homeolog	Xenopus laevis	13-17
8453665-5	1993	CHL1 mRNA is found predominantly in roots and displays nitrate- and pH-dependent regulation.	Nitrates	55-62	nitrate transporter 1.1	Arabidopsis thaliana	0-4
8483458-4	1993	Some of these nit-1 or nit-2 mutants were also defective in pathways not directly related to nitrate assimilation, such as those of amino acids and purines.	Nitrates	93-100	uncharacterized protein	Chlamydomonas reinhardtii	23-28
8437565-5	1993	The accumulation of both leaf and root NiR mRNAs was induced by nitrate and repressed by nitrate- or ammonium-derived metabolites.	Nitrates	64-71	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	39-42
8440160-11	1993	The effect of captopril in nitrate tolerance is apparently due to an addition of the anti-ischaemic action of the ACE inhibitor (31%) and the residual effect of the nitrate (26%).	Nitrates	27-34	angiotensin I converting enzyme	Homo sapiens	114-117
8447474-2	1993	Incubation of vascular smooth muscle cells with IL-1 beta resulted in significant accumulation of nitrite and nitrate in the culture media.	Nitrates	110-117	interleukin 1 beta	Homo sapiens	48-57
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	171-178	plasminogen	Homo sapiens	0-7
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	171-178	interleukin 1 beta	Homo sapiens	129-138
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	289-296	plasminogen	Homo sapiens	0-7
8447474-3	1993	Plasmin, either added exogenously or generated by the reaction of tissue plasminogen activator with plasminogen, potentiated the IL-1 beta-mediated release of nitrite and nitrate from smooth muscle cells in a concentration-dependent manner, without affecting the production of nitrite and nitrate from cells untreated with IL-1 beta.	Nitrates	289-296	interleukin 1 beta	Homo sapiens	129-138
8435934-7	1993	ACE inhibitors may reduce tolerance to nitrates, reduce angina in some but not all studies, and limit smooth muscle cell proliferation (and perhaps restenosis) induced by experimental balloon angioplasty.	Nitrates	39-47	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	0-3
8499119-3	1993	In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	95-98
8499119-3	1993	In spite of the highly favourable results regarding mortality shown by the latest studies with ACE inhibitors, the nitrates still occupy an essential place in the therapy of patients with heart failure, since they have the advantage of a much faster onset of action and are more effective in relieving symptoms than ACE inhibitors.	Nitrates	115-123	angiotensin I converting enzyme	Homo sapiens	316-319
8423095-3	1993	Intraperitoneal injection of mice with BCG increased urinary nitrate (NO3-) excretion coincident with development of activated macrophages capable of secreting nitrogen oxides and inhibiting F. tularensis growth in vitro.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Mus musculus	70-73
8278505-2	1993	A possible physiological role of this enzyme could be in the turnover of nitrate reductase (NR) and, as such, it could be of great importance in regulating the assimilation of nitrate.	Nitrates	73-80	nitrate reductase [NADH] 1	Zea mays	92-94
8282225-1	1993	The production of nitrate (NO3-) and nitrite (NO2-) from macrophage-derived NO was studied using EPR and spin trapping.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
8437565-5	1993	The accumulation of both leaf and root NiR mRNAs was induced by nitrate and repressed by nitrate- or ammonium-derived metabolites.	Nitrates	89-96	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	39-42
8437574-7	1993	Nitrite reductase activity, measured with dithionite-reduced methyl viologen as electron donor, of the nitrate-treated homozygous nir1 mutant was much reduced but NADH-nitrate reductase activity was elevated compared to wild-type plants.	Nitrates	103-110	PITPNM family member 3	Homo sapiens	130-134
16653241-3	1992	Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels.	Nitrates	102-109	MLO-like protein 4	Zea mays	132-136
8419922-1	1993	Urinary nitrate (NO3) is the stable end product of nitric oxide, which is formed, in turn, from a guanidino nitrogen of arginine.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
1336460-1	1992	The structures of human carbonic-anhydrase-II complexes with the anionic inhibitors hydrogen sulphide (HS-) and nitrate (NO3-) have been determined by X-ray diffraction at 0.19-nm resolution from crystals soaked at pH 7.8 and 6.0, respectively.	Nitrates	112-119	carbonic anhydrase 2	Homo sapiens	24-45
1336460-1	1992	The structures of human carbonic-anhydrase-II complexes with the anionic inhibitors hydrogen sulphide (HS-) and nitrate (NO3-) have been determined by X-ray diffraction at 0.19-nm resolution from crystals soaked at pH 7.8 and 6.0, respectively.	Nitrates	112-119	NBL1, DAN family BMP antagonist	Homo sapiens	121-124
16653241-3	1992	Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels.	Nitrates	102-109	carbonic anhydrase	Zea mays	141-143
16653241-3	1992	Addition of methionine sulfoximine (MSX), a specific inhibitor of glutamine synthetase, inhibited the nitrate-dependent increase of PEPC and CA mRNA but did not affect the glutamine-dependent increase of PEPC and CA mRNA levels.	Nitrates	102-109	MLO-like protein 4	Zea mays	204-208
16652938-6	1992	Simultaneous addition of high nitrate and zeatin to leaves detached from N-deficient maize plants caused a large and rapid increase in PEPC and CA mRNA levels.	Nitrates	30-37	MLO-like protein 4	Zea mays	135-139
16653041-1	1992	Effects of NO(2) (-), ClO(3) (-), and ClO(2) (-) on the induction of nitrate transport and nitrate reductase activity (NRA) as well as their effects on NO(3) (-) influx into roots of intact barley (Hordeum vulgare cv Klondike) seedlings were investigated.	Nitrates	69-76	Clo2	Hordeum vulgare	38-44
1500182-0	1992	In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria.	Nitrates	33-40	tumor necrosis factor	Mus musculus	44-65
1442583-6	1992	The results of this study demonstrate a preserved vasodilatory effect of organic nitrates in patients already treated with ACE inhibitors.	Nitrates	81-89	angiotensin I converting enzyme	Homo sapiens	123-126
1442583-7	1992	Nitrates mediated improvement in right and left ventricular filling pressures, and reduction of pulmonary hypertension demonstrates a rationale for the use of these therapeutic methods in combination and suggest the need for long-term evaluation of the effect of nitrate therapy in patients with chronic CHF already treated with ACE inhibitors.	Nitrates	0-8	angiotensin I converting enzyme	Homo sapiens	329-332
16652938-6	1992	Simultaneous addition of high nitrate and zeatin to leaves detached from N-deficient maize plants caused a large and rapid increase in PEPC and CA mRNA levels.	Nitrates	30-37	carbonic anhydrase	Zea mays	144-146
16653003-4	1992	The addition of nitrate to wheat seedlings (Triticum aestivum) grown in the absence of exogenous nitrogen has a dramatic, if transient, impact on sucrose formation and on the activities of sucrose phosphate synthase (which is inactivated) and phosphoenolpyruvate carboxylase (which is activated).	Nitrates	16-23	phosphoenolpyruvate carboxylase 2	Triticum aestivum	243-274
1621630-5	1992	Infants are particularly susceptible to nitrate poisoning because fetal hemoglobin is more readily oxidized to methemoglobin.	Nitrates	40-47	hemoglobin subunit gamma 2	Homo sapiens	111-124
16669032-5	1992	Regulation of the phosphorylation of SPS may provide a general mechanism whereby sucrose formation is coordinated with the rate of photosynthesis and the rate of nitrate assimilation.	Nitrates	162-169	sucrose-phosphate synthase	Zea mays	37-40
1352550-0	1992	Cytochrome P-450 mediates bioactivation of organic nitrates.	Nitrates	51-59	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
1377225-5	1992	Increased levels of nitrite (NO2-) and nitrate (NO3-) in culture supernatants were associated with NADPH-dependent NOS activity in the cell lysates.	Nitrates	39-46	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
1352550-10	1992	These findings suggest that in intact cells bioactivation of, i.e., nitric oxide formation from organic nitrates is mediated by a cytochrome P-450 enzyme system rather than by glutathione S-transferase or free thiols.	Nitrates	104-112	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	130-146
1632143-4	1992	Calcium channel blockers (nifedipine and verapamil) or nitrates (isosorbide dinitrate) decrease LES pressure but do little to the clinical symptomatology of patients with achalasia; however such drug therapy may be tried as an adjunct in patients who remain symptomatic after pneumatic dilatations or myotomy.	Nitrates	55-63	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	96-99
24178079-0	1992	Coaction of light, nitrate and a plastidic factor in controlling nitrite-reductase gene expression in tobacco.	Nitrates	19-26	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	65-82
24178079-1	1992	Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light.	Nitrates	54-61	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	0-17
24178079-1	1992	Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light.	Nitrates	54-61	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	19-22
24178079-1	1992	Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light.	Nitrates	100-107	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	0-17
24178079-1	1992	Nitrite reductase (NIR; EC 1.7.7.1) - a key enzyme of nitrate reduction - is known to be induced by nitrate and light.	Nitrates	100-107	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	19-22
24178079-2	1992	In the present study with tobacco (Nicotiana tabacum L.) seedlings the dependency of NIR gene expression on nitrate, light and a plastidic factor was investigated to establish the nature of the coaction between these controlling factors.	Nitrates	108-115	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	85-88
24178079-9	1992	(iv) Northern blot analysis of NIR-transcript levels indicated that a low transcript level existed in the absence of nitrate and light; however, this level appeared to be increased slightly by light (in the absence of nitrate) and by nitrate (in the absence of light).	Nitrates	117-124	ferredoxin--nitrite reductase, chloroplastic-like	Nicotiana tabacum	31-34
1375656-5	1992	Plasma levels of nitrate (NO3-), the stable end metabolic product of .N = O synthesis, were measured before and at the end of IL-2 treatment cycles.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
1534867-2	1992	Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo).	Nitrates	121-128	nitrate reductase 1	Arabidopsis thaliana	166-183
1533499-3	1992	The enzyme was inhibited by the vacuolar ATPase inhibitors nitrate and N-ethylmaleimide; 4-chloro-7-nitrobenzofurazan (NBD-Cl) was also inhibitory.	Nitrates	59-66	tRNA(Met) cytidine acetyltransferase TmcA	Saccharolobus solfataricus	41-47
1534867-2	1992	Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo).	Nitrates	121-128	nitrate reductase 1	Arabidopsis thaliana	185-187
1534867-2	1992	Hundreds of chlorate-resistant mutants have been identified in plants, and almost all have been found to be defective in nitrate reduction due to mutations in either nitrate reductase (NR) structural genes or genes required for the synthesis of the NR cofactor molybdenum-pterin (MoCo).	Nitrates	121-128	nitrate reductase 1	Arabidopsis thaliana	249-251
1530430-6	1992	The interactions of nitrate derivatives with molecules used as platelet inhibitors, such as aspirin, require further study as do interactions with heparin (possible induction of resistance by a qualitative anti-thrombin III deficiency) and thrombolytics (increased clearance of tissue type plasminogen activator).	Nitrates	20-27	plasminogen activator, tissue type	Homo sapiens	278-311
24178047-6	1992	It appears that in bundle-sheath cells of maize the nitrate-assimilatory capacities of glutamine synthetase (located mainly in the cytosol) and of glutamate synthase (located in the stroma) are high enough to meet the demands of whole maize leaves.	Nitrates	52-59	ferredoxin-dependent glutamate synthase, chloroplastic	Zea mays	147-165
1314486-3	1992	A combination of lipopolysaccharide (LPS), interferon-gamma, tumor necrosis factor, and interleukin-1 stimulates the biosynthesis of large quantities of nitrite and nitrate (NO2- + NO3-).	Nitrates	165-172	interferon gamma	Rattus norvegicus	43-59
1541678-4	1992	Activity of this pathway was evaluated by measuring serum and urine nitrate (the stable degradation product of NO) during IL-2 therapy.	Nitrates	68-75	interleukin 2	Homo sapiens	122-126
16668807-0	1992	Effects of Nitrate and Ammonium on Gene Expression of Phosphoenolpyruvate Carboxylase and Nitrogen Metabolism in Maize Leaf Tissue during Recovery from Nitrogen Stress.	Nitrates	11-18	MLO-like protein 4	Zea mays	54-85
16668807-1	1992	We previously showed that the selective accumulation of phosphoenolpyruvate carboxylase (PEPC) in photosynthetically maturing maize (Zea mays L.) leaf cells induced by nitrate supply to nitrogen-starved plants was primarily a consequence of the level of its mRNA (B Sugiharto, K Miyata, H Nakamoto, H Sasakawa, T Sugiyama [1990] Plant Physiol 92: 963-969).	Nitrates	168-175	MLO-like protein 4	Zea mays	56-87
16668807-1	1992	We previously showed that the selective accumulation of phosphoenolpyruvate carboxylase (PEPC) in photosynthetically maturing maize (Zea mays L.) leaf cells induced by nitrate supply to nitrogen-starved plants was primarily a consequence of the level of its mRNA (B Sugiharto, K Miyata, H Nakamoto, H Sasakawa, T Sugiyama [1990] Plant Physiol 92: 963-969).	Nitrates	168-175	MLO-like protein 4	Zea mays	89-93
1558158-3	1992	Substitution of Cl- with nitrate (101 mM) stimulated renin secretion.	Nitrates	25-32	renin	Rattus norvegicus	53-58
1542684-1	1992	Nitrate reductase, the first enzyme in nitrate assimilation, is located at the crossroad of two energy-consuming pathways: nitrate assimilation and carbon fixation.	Nitrates	39-46	nitrate reductase 1	Arabidopsis thaliana	0-17
1542684-1	1992	Nitrate reductase, the first enzyme in nitrate assimilation, is located at the crossroad of two energy-consuming pathways: nitrate assimilation and carbon fixation.	Nitrates	123-130	nitrate reductase 1	Arabidopsis thaliana	0-17
1541678-5	1992	IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively).	Nitrates	86-93	interleukin 2	Homo sapiens	0-4
1541678-5	1992	IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively).	Nitrates	221-228	interleukin 2	Homo sapiens	0-4
1541678-6	1992	IL-2-induced renal dysfunction made only a minor contribution to increased serum nitrate levels.	Nitrates	81-88	interleukin 2	Homo sapiens	0-4
1541678-8	1992	Our results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.	Nitrates	41-48	interleukin 2	Homo sapiens	81-85
1557942-4	1992	EDRF-NO as well as NO generated from vasodilator nitrates act by activation of soluble guanylate cyclase, elevating cellular cyclic GMP levels, causing vasodilatation and inhibition of platelet aggregation.	Nitrates	49-57	5'-nucleotidase, cytosolic II	Homo sapiens	132-135
1606187-4	1992	Bradykinin had a stimulating effect on human and bovine endothelial cells and led to a threefold increase of nitrite/nitrate in endothelial cell column perfusates compared to those of unstimulated cells.	Nitrates	117-124	kininogen 1	Homo sapiens	0-10
16668656-3	1992	In mutants defective at the regulatory locus for nitrate reductase (nit-2), very low levels of nitrite uptake and nitrite reductase activities were expressed even in the presence of nitrate or nitrite.	Nitrates	49-56	uncharacterized protein	Chlamydomonas reinhardtii	68-73
1462853-6	1992	As a consequence, SH-containing ACE-inhibitors may potentiate nitrates, because they act as exogenous nitrovasodilators, and reverse tolerance to their therapeutic effect.	Nitrates	62-70	angiotensin I converting enzyme	Homo sapiens	32-35
1731978-0	1992	Nitrate reductase transcript is expressed in the primary response of maize to environmental nitrate.	Nitrates	92-99	nitrate reductase [NADH] 1	Zea mays	0-17
15092051-4	1992	It is suggested that the most likely mechanism for this nitrate production was due to the solution of N2O5 and NO3 formed from the reaction of NO2 with O3.	Nitrates	56-63	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
1731978-1	1992	The nitrate induction of NADH:nitrate reductase mRNA in maize roots, scutella and leaves was investigated in the presence and absence of inhibitors of protein synthesis.	Nitrates	4-11	nitrate reductase [NADH] 1	Zea mays	30-47
1731978-2	1992	In the absence of inhibitors, nitrate treatment caused a fairly rapid (2 to 3 h) increase in the level of the nitrate reductase transcript in all tissues.	Nitrates	30-37	nitrate reductase [NADH] 1	Zea mays	110-127
1731978-3	1992	When cytoplasmic protein synthesis was inhibited by cycloheximide, nitrate reductase mRNA was induced by nitrate in all tissues to levels equal to or greater than those found with nitrate treatment alone.	Nitrates	105-112	nitrate reductase [NADH] 1	Zea mays	67-84
1790782-4	1991	At least one further site in the nitrate bioconversion cascade, possibly at the level of NO generation appears to be involved in tolerance development, which may also affect the non-nitrate vasodilator SIN-1.	Nitrates	33-40	MAPK associated protein 1	Homo sapiens	202-207
1720843-3	1991	In nitrate-tolerant hearts of rats pretreated with isosorbide dinitrate (15 mg daily), the increase in coronary flow by nitroglycerin and bradykinin was significantly less when compared to control hearts.	Nitrates	3-10	kininogen 1	Homo sapiens	138-148
16668525-9	1991	Chlorate-treated plants still retain the capacity to make functional NR because NR activity could be restored by irrigating the chlorate-treated plants with nitrate.	Nitrates	157-164	nitrate reductase 1	Arabidopsis thaliana	80-82
1911837-3	1991	Addition of the AE1 specific inhibitor 4,4"-dinitrostilbene-2,2"-disulfonate markedly reduced this line-broadening, indicating that the broadening was predominantly due to a specific interaction between nitrate and AE1.	Nitrates	203-210	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	16-19
1911837-0	1991	The binding of nitrate to the human anion exchange protein (AE1) studied with 14N nuclear magnetic resonance.	Nitrates	15-22	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	60-63
1911837-4	1991	The dependence of the AE1 specific line-broadening on nitrate concentration had a first-order dissociation constant KD of 6.9 +/- 0.9 mM.	Nitrates	54-61	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	22-25
1911837-5	1991	In contrast, Cl- interaction with AE1 studied by 35Cl-NMR showed a chloride concentration-dependent line-broadening with a KD of 74 +/- 10 mM, indicating that AE1 has a higher affinity for nitrate than for chloride.	Nitrates	189-196	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	34-37
1911837-5	1991	In contrast, Cl- interaction with AE1 studied by 35Cl-NMR showed a chloride concentration-dependent line-broadening with a KD of 74 +/- 10 mM, indicating that AE1 has a higher affinity for nitrate than for chloride.	Nitrates	189-196	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	159-162
1911837-8	1991	Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction.	Nitrates	0-7	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	86-89
1911837-8	1991	Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction.	Nitrates	0-7	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	123-126
1911837-8	1991	Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction.	Nitrates	73-80	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	86-89
1911837-8	1991	Nitrate is a structural analog of bicarbonate, making the interaction of nitrate with AE1 a good model for the bicarbonate-AE1 interaction.	Nitrates	73-80	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	123-126
1911837-9	1991	The 14N-NMR nitrate binding assay, along with the 35Cl-NMR binding assay now in use, will provide a powerful tool for studying the structure of the AE1 binding site for both physiologic substrates, bicarbonate and chloride.	Nitrates	12-19	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	148-151
1901528-12	1991	Body weight increased only in the placebo group, suggesting prevention of nitrate-induced volume expansion in the ACE inhibitor groups.	Nitrates	74-81	angiotensin I converting enzyme	Homo sapiens	114-117
1712676-11	1991	The activity for forming L-citrulline and nitrite/nitrate from L-arginine was markedly induced by treatment with either LPS alone or LPS + IFN-gamma but not with IFN-gamma.	Nitrates	50-57	interferon gamma	Mus musculus	139-148
1831867-1	1991	Effects of nicorandil (2-nicotinamidoethyl nitrate), a nitrate derivative with a K+ channel-opening action, on endothelin-1 (ET)-induced effects on peripheral blood vessels were studied using a hind-limb perfusion preparation in rats.	Nitrates	43-50	endothelin 1	Rattus norvegicus	111-123
1903680-0	1991	Hirudin and nitrates inhibit the thrombin-induced release of endothelin from the intact porcine aorta.	Nitrates	12-20	coagulation factor II, thrombin	Homo sapiens	33-41
1903680-6	1991	However, the nitrates fully inhibited the release of the peptide induced by thrombin (4 units/ml).	Nitrates	13-21	coagulation factor II, thrombin	Homo sapiens	76-84
1874272-3	1991	EDRF-NO and NO generated from vasodilator nitrates work by activation of soluble guanylate cyclase, elevating cyclic guanosine monophosphate (GMP) levels to cause vasodilatation and inhibition of platelet aggregation.	Nitrates	42-50	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
16668164-3	1991	Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2.	Nitrates	9-16	nitrate reductase 1	Arabidopsis thaliana	71-74
16668164-3	1991	Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2.	Nitrates	9-16	nitrate reductase 2	Arabidopsis thaliana	143-146
16668164-3	1991	Although nitrate-induction kinetics of the two genes are very similar, NR1 is expressed in the absence of nitrate at a higher basal level than NR2.	Nitrates	106-113	nitrate reductase 1	Arabidopsis thaliana	71-74
1906734-6	1991	Dipyridamole, a phosphodiesterase (PDe) inhibitor, significantly potentiated the responses to SIN1 on control rings (EC50 = 57.1 +/- 1.8 nM), and on NTG-tolerant rings it reversed the responsiveness to SIN1 (EC50 = 88.9 +/- 9.2 nM), which suggests that nitrate tolerance may be partially due to an increase in PDe activity.	Nitrates	253-260	MAPK associated protein 1	Homo sapiens	94-98
1901528-13	1991	CONCLUSIONS: This study demonstrates that ACE inhibitors may prevent nitrate tolerance to long-term nitrate therapy.	Nitrates	69-76	angiotensin I converting enzyme	Homo sapiens	42-45
1901528-13	1991	CONCLUSIONS: This study demonstrates that ACE inhibitors may prevent nitrate tolerance to long-term nitrate therapy.	Nitrates	100-107	angiotensin I converting enzyme	Homo sapiens	42-45
1906734-0	1991	Effect of nitrate tolerance and dipyridamole on the response to SIN1 in the human isolated saphenous vein.	Nitrates	10-17	MAPK associated protein 1	Homo sapiens	64-68
16667965-1	1991	The level of nitrate reductase (NR) and nitrite reductase (NiR) varied in both shoot and root tissue from nitrate-fed Zea mays L. grown under a 16-hour light/8-hour dark regime over a 10-day period postgermination, with peak activity occurring in days 5 to 6.	Nitrates	13-20	nitrate reductase [NADH] 1	Zea mays	32-34
1846742-2	1991	Reduction of nitrate, or nitrite, to N2O under aerobic conditions involves NO as an intermediate, as judged by trapping experiments with the ferric form of extracellular horse heart cytochrome c and the demonstration that the cells possess a nitric oxide reductase activity.	Nitrates	13-20	cytochrome c, somatic	Equus caballus	182-194
1988109-2	1991	We show here that FAA and structurally related analogues increase plasma nitrite plus nitrate (NO2-/NO3-) levels in mice.	Nitrates	86-93	NBL1, DAN family BMP antagonist	Mus musculus	95-103
1864311-0	1991	Nitrate-induced hypothyroidism is associated with a reduced concentration of growth hormone-releasing factor in hypothalamic tissue of rats.	Nitrates	0-7	growth hormone releasing hormone	Rattus norvegicus	77-108
1864311-7	1991	Nitrate exposure is characterized by hypothyroidism, food intake depression, low Sm-C/IGF-I concentrations in plasma and a decreased hypothalamic GRF content.	Nitrates	0-7	insulin-like growth factor 1	Rattus norvegicus	86-91
1989691-4	1991	Nitrate reductase specific mRNA can be observed within 2 h after nitrate treatment.	Nitrates	65-72	inducible nitrate reductase [NADH] 1	Glycine max	0-17
1989691-5	1991	Levels peaked 48 h after nitrate treatment, while the addition of glutamine to nitrate diminished amounts of nitrate reductase specific mRNA.	Nitrates	79-86	inducible nitrate reductase [NADH] 1	Glycine max	109-126
1859433-0	1991	Regulation of phosphoenolpyruvate carboxylase from maize leaves by nitrate and alanine.	Nitrates	67-74	MLO-like protein 4	Zea mays	14-45
1859433-1	1991	Nitrate and alanine were found to stimulate partially purified maize leaf phosphoenolpyruvate carboxylase under specific assay conditions.	Nitrates	0-7	MLO-like protein 4	Zea mays	74-105
1649801-5	1991	In a cohort of 1,148 male fertilizer workers who had never been exposed to nitrate, there was an increased incidence of lung cancer (SMR = 151,95% CI = 103-220) but not of stomach cancer or prostate cancer.	Nitrates	75-82	LY6/PLAUR domain containing 4	Homo sapiens	133-136
1776339-1	1991	SIN 1, the bioactive metabolite of molsidomine, not only appears to lack the problem of inducing nitrate tolerance, but also exerts antiaggregatory and fibrinolytic properties.	Nitrates	97-104	MAPK associated protein 1	Homo sapiens	0-5
1965331-7	1990	These results suggest that in intact cells, glyceryl trinitrate-induced cyclic GMP stimulation is dependent on cytochrome P-450 enzymes which may be relevant for nitric oxide formation from organic nitrates.	Nitrates	198-206	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	111-127
2124251-1	1990	The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma).	Nitrates	89-96	NBL1, DAN family BMP antagonist	Mus musculus	98-101
2124251-1	1990	The present study demonstrates that murine dermal fibroblasts produce nitrite (NO2-) and nitrate (NO3-) upon treatment with interferon gamma (IFN-gamma).	Nitrates	89-96	interferon gamma	Mus musculus	124-151
24197373-2	1990	This is demonstrated by the properties of the associated ATPase: high vanadate sensitivity, azide and nitrate insensitivity, sharp pH optimum around 6.5, and high specificity for ATP as substrate.	Nitrates	102-109	dynein axonemal heavy chain 8	Homo sapiens	57-63
2128204-7	1990	This suggests that the biotransformation of organic nitrates can occur through the direct interaction with the heme moiety of cytochrome P-450.	Nitrates	52-60	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	126-142
2128204-10	1990	These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation.	Nitrates	89-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
2128204-10	1990	These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation.	Nitrates	89-97	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	139-155
2128204-10	1990	These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation.	Nitrates	224-232	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	24-40
2128204-10	1990	These data suggest that cytochrome P-450 is involved in the biotransformation of organic nitrates and raises the possibility that vascular cytochrome P-450 may play a role in the mechanism-based biotransformation of organic nitrates, the result of which is vascular smooth muscle relaxation.	Nitrates	224-232	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	139-155
2382514-3	1990	Nitrate (in the assayed range 0 to 800 mg/L) and high concentrations of ascorbic acid (4 to 8 g/L) slightly inhibited cathepsin D.	Nitrates	0-7	cathepsin D	Homo sapiens	118-129
16667714-3	1990	CA activity was reduced in plants grown under nitrogen deficiency and recovered only slowly when supplemented with nitrate.	Nitrates	115-122	carbonic anhydrase	Zea mays	0-2
24197091-5	1990	Seedlings germinated from seeds (pericarp was removed) without external N-supply are able to take up nitrate immediately upon exposure via a low-capacity uptake system (vmax = 0.8 mumol NO 3 (-)  (g root FW)(-1) h(-1); Ks = 0.12 mM).	Nitrates	101-108	NBL1, DAN family BMP antagonist	Homo sapiens	186-190
24197091-7	1990	Induction of a high-capacity nitrate-uptake system (vmax = 3.4 mumol NO 3 (-)  (g root FW)(-1) h(-1); Ks = 0.08 mM) by externally supplied nitrate occurs after a 20-min lag and requires protein synthesis.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	69-73
24197091-7	1990	Induction of a high-capacity nitrate-uptake system (vmax = 3.4 mumol NO 3 (-)  (g root FW)(-1) h(-1); Ks = 0.08 mM) by externally supplied nitrate occurs after a 20-min lag and requires protein synthesis.	Nitrates	139-146	NBL1, DAN family BMP antagonist	Homo sapiens	69-73
2354740-6	1990	Average nitrate intake was 52 mg NO3-/day, about 25% of the ADI.	Nitrates	8-15	NBL1, DAN family BMP antagonist	Homo sapiens	33-36
1972336-10	1990	At this temperature, even weak chaotropic anions (fluoride, chloride and nitrate), while in combination with non-ionic detergents that solubilized mosquito AChE efficiently, reduced the enzyme activity of these fractions.	Nitrates	73-80	acetylcholinesterase (Cartwright blood group)	Homo sapiens	156-160
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	75-82	NOD3	Glycine max	20-26
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	75-82	NOD3	Glycine max	28-34
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	75-82	NOD3	Glycine max	40-46
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	88-95	NOD3	Glycine max	20-26
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	88-95	NOD3	Glycine max	28-34
16667382-2	1990	nodulation mutants (NOD1-3, NOD2-4, and NOD3-7) were partially tolerant to nitrate when nitrate was supplied simultaneously with inoculation at the time of transplanting.	Nitrates	88-95	NOD3	Glycine max	40-46
16667382-6	1990	NOD1-3 was most tolerant of nitrate among the mutants tested and showed the highest relative abundance of ureides.	Nitrates	28-35	NOD3	Glycine max	0-6
16667382-10	1990	Unexpectedly, nitrate treatment also increased the rate of ureide degradative capacity of leaves in both NOD1-3 and Williams.	Nitrates	14-21	NOD3	Glycine max	105-111
2102014-4	1990	Since the eight day of perfusion all the effluents had an important concentration of nitrate (Figure 1), exceeding in them, the sum of [No-2-N] an [NO-3-N] (Table 1) the concentration of th NO-2-N of the perfusion solution.	Nitrates	85-92	NBL1, DAN family BMP antagonist	Homo sapiens	148-152
2115855-9	1990	The cause of nitrate tolerance is regarded as an insufficient or absent stimulation of guanylate cyclase and, consequently, inadequate generation of cyclic GMP due to availability of thiol substrate.	Nitrates	13-20	5'-nucleotidase, cytosolic II	Homo sapiens	156-159
2111676-3	1990	The mechanism of tolerance to nitrates is multifactorial, related on the one hand to depletion of sulfhydryl groups in the body and on the other to activation of the sympathetic and renin-angiotensin systems.	Nitrates	30-38	renin	Homo sapiens	182-187
33971470-1	2021	Fluoride (F-) and nitrate (NO3-) in groundwater have caused serious health problems worldwide.	Nitrates	18-25	NBL1, DAN family BMP antagonist	Homo sapiens	27-30
2113002-10	1990	Thus, the administration of low doses of nitrates that act by means of the NO radical can increase the diameter in the stenosis, since the physiological dilator (EDRF) is no longer present.	Nitrates	41-49	alpha hemoglobin stabilizing protein	Homo sapiens	162-166
33968104-1	2021	As important electron carriers, ferredoxin (Fd) proteins play important roles in photosynthesis, and the assimilation of CO2, nitrate, sulfate, and other metabolites.	Nitrates	126-133	ferredoxin	Zea mays	32-42
33822357-21	2021	Based on low-certainty evidence, beta-blockers plus nitrates had a higher number of "any adverse events (number of participants)" than beta-blockers alone (OR 3.41, 95% CrI 1.11 to 11.28; 1 trial, 57 participants).	Nitrates	52-60	EP300 interacting inhibitor of differentiation 1	Homo sapiens	169-174
33822357-24	2021	Based on low-certainty evidence, any variceal bleed was higher in nitrates than beta-blockers (direct comparison HR 6.40, 95% CrI 1.58 to 47.42; 1 trial, 52 participants).	Nitrates	66-74	EP300 interacting inhibitor of differentiation 1	Homo sapiens	126-131
33804377-4	2021	The nitrate concentrations in the drinking water ranged from 3.55 mg/L to 26.75 mg/L as NO3-.	Nitrates	4-11	NBL1, DAN family BMP antagonist	Homo sapiens	88-91
29378007-9	2018	Nitrate-independent phenotypes were found with higher seed abortion in atg5 and early browing, higher total protein concentrations in the viable seeds of this mutant as compared to the WT.	Nitrates	0-7	SAC domain-containing protein 8	Arabidopsis thaliana	71-75
33031018-1	2020	Ingestion of dietary nitrate (NO3-) is associated with improved exercise tolerance and reduced oxygen (O2) cost of exercise, ascribed to enhanced mitochondrial efficiency, muscle contractile function or other factors.	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
32794734-5	2020	Adding nitrate to a solution of the [Cm(nPr-BTP)3]3+ complex in 2-propanol shifts the Cm(III) emission band from 613.1 to 617.3 nm.	Nitrates	7-14	neuronal pentraxin receptor	Homo sapiens	40-43
32794734-12	2020	The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex.	Nitrates	71-78	neuronal pentraxin receptor	Homo sapiens	34-37
32794734-12	2020	The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex.	Nitrates	71-78	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
32794734-12	2020	The vibronic side band of the [Cm(nPr-BTP)3(NO3)]2+ complex exhibits a nitrate stretching mode not observed in the [Cm(nPr-BTP)3]3+ complex.	Nitrates	71-78	neuronal pentraxin receptor	Homo sapiens	119-122
32794734-13	2020	Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate.	Nitrates	112-119	neuronal pentraxin receptor	Homo sapiens	20-23
32794734-13	2020	Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate.	Nitrates	112-119	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
32794734-13	2020	Moreover, XPS on [M(nPr-BTP)3(NO3)](NO3)2 (M = Eu, Am) yields signals from both non-coordinated and coordinated nitrate.	Nitrates	112-119	NBL1, DAN family BMP antagonist	Homo sapiens	36-39
32794734-14	2020	Finally, DFT calculations reveal that the energetically most favored structure is obtained if the nitrate is positioned on the C2 axis of the D3 symmetrical [Cm(nPr-BTP)3]3+ complex with a bond distance of 413 pm.	Nitrates	98-105	neuronal pentraxin receptor	Homo sapiens	161-164
25805369-7	2015	The spatial distribution of NO3--N export from hydrologic response units (HRUs) identified the agricultural areas with surplus N that are vulnerable to nitrate contamination.	Nitrates	152-159	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
31139154-9	2019	The maximum rates of different redox metabolisms (mM electron acceptors reduced g-1 soil d-1) in soil containing biogenic nitrate followed as: NO3 1- reduction 4.01 +- 0.22, Fe3+ reduction 5.37 +- 0.12, SO4 2- reduction 9.56 +- 0.16, and CH4 production (mug g-1 soil) 0.46 +- 0.05.	Nitrates	122-129	NBL1, DAN family BMP antagonist	Homo sapiens	143-146
31139154-11	2019	Raman spectra indicated that aliphatic hydrocarbons increased in soil during nitrification, and these compounds probably bind to NO3 to form biogenic nitrate.	Nitrates	150-157	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
25762424-5	2015	The best retrieval of modeled nitrate (R2=0.527, root mean square error (RMSE)=3.72, and mean normalized bias (MNB)=0.821) was observed for the postmonsoon season due to the better retrieval of both SST MODIS (28 February 2012, R2=0.651, RMSE=2.037, and MNB=0.068) and chl OCM-2 (R2=0.534, RMSE=0.317, and MNB=0.27).	Nitrates	30-37	oncomodulin 2	Homo sapiens	273-278
25762424-6	2015	Present results confirm that the chl OCM-2 and SST MODIS retrieve nitrate well than the MODIS-derived chl and SST largely due to the better retrieval of chl by OCM-2 than MODIS.	Nitrates	66-73	oncomodulin 2	Homo sapiens	37-42
23214130-4	2012	Two families of proton-coupled symporters, NRT1 and NRT2, and one type of proton-coupled antiporters, CIC, have been shown to be involved in nitrate transport in higher plants.	Nitrates	141-148	nitrate transporter 1.1	Arabidopsis thaliana	43-47
23214130-5	2012	The recent progress in research on NRT1 proteins has shed the light on the localization and physiological function of those nitrate transporters in the NO3(-) uptake, NO3(-) cell-to-cell and tissue-to-tissue distribution, nitrates accumulation and efflux within the model plant Arabidopsis thaliana.	Nitrates	222-230	nitrate transporter 1.1	Arabidopsis thaliana	35-39
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrates	146-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
7579165-3	1995	In this paper, we present detailed evidence to show that PMA mimics the red light effect and follows similar kinetics to enhance NR steady-state transcript accumulation in a nitrate-dependent manner.	Nitrates	174-181	nitrate reductase [NADH] 1	Zea mays	129-131
34953459-3	2022	The voltammetry showed that the redox couple of Co(II)/Co(III) and Ni(II)/Ni(III) as the mediator catalytically transferred the electrons of NO2-/NO3-; the Ni site had a relatively high transfer coefficient and diffusive current, while the Co site was better in the capacitive removal of the nitrite and nitrate compounds.	Nitrates	304-311	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-54
34743794-1	2022	The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water.	Nitrates	35-42	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
34863569-5	2022	The AO7 removal performance of PC-MnOx was slightly decreased in natural waterbodies and in the presence of CO32-, while it showed an anti-interference capacity for Cl-, NO3- and humic acid.	Nitrates	170-174	ring finger protein 25	Homo sapiens	4-7
34743794-1	2022	The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water.	Nitrates	185-192	NBL1, DAN family BMP antagonist	Homo sapiens	44-47
34743794-1	2022	The green and efficient removal of nitrate (NO3-) in groundwater is a primary concern nowadays, and membrane capacitive deionization (MCDI) is an emerging technology for the removal of nitrate (NO3-) from water.	Nitrates	185-192	NBL1, DAN family BMP antagonist	Homo sapiens	194-197
34743794-4	2022	The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode.	Nitrates	367-374	NBL1, DAN family BMP antagonist	Homo sapiens	28-31
34743794-4	2022	The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode.	Nitrates	367-374	NBL1, DAN family BMP antagonist	Homo sapiens	120-123
34743794-4	2022	The results showed that the NO3- denitrification removal increased with raised voltage and in proportion to the initial NO3- concentration within certain limits, wherein the removal rate reached a maximum of 53.3% in the single-solute solution of 200 mg L-1 NaNO3 at 1.8 V. Nevertheless, overhigh voltage or initial NO3- concentration would have a negative effect on nitrate removal, which was caused by multiple factors, including side reactions in the solution, fouling of activated carbon fiber and anion exchange membrane, and corrosion of copper electrode.	Nitrates	367-374	NBL1, DAN family BMP antagonist	Homo sapiens	316-319
34806833-0	2022	Electrified conversion of contaminated water to value: selective conversion of aqueous nitrate to ammonia in a PEM cell.	Nitrates	87-94	mucin 1, cell surface associated	Homo sapiens	111-114
34896495-4	2022	Nowadays, there is increasing concern about the presence of nitrates (NO3-) in groundwaters as a consequence of the intensive use of fertilizers and other anthropogenic sources, such as sewage or industrial wastewater discharge.	Nitrates	60-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
34896495-6	2022	Thus, this work collects data from the literature regarding the presence of nitrates in groundwater, and, simultaneously, it reviews the main alternatives available to remove NO3- from groundwater sources.	Nitrates	76-84	NBL1, DAN family BMP antagonist	Homo sapiens	175-178
34806833-1	2022	The application of a polymer electrolyte membrane (PEM) electrolytic cell for continuous conversion of nitrate, one of the contaminants in water, to ammonia at the cathode was explored in the present work.	Nitrates	103-110	mucin 1, cell surface associated	Homo sapiens	51-54
34500153-4	2022	Then, the dissociation of CMC-DD2 was efficiently triggered by intracellular hydrogen peroxide (H2O2) with the release of DNA damaging agents, including nitrate anions, hydroxyl radicals ( OH) and DD2.	Nitrates	153-160	aldo-keto reductase family 1 member C2	Homo sapiens	30-33
34343879-1	2022	Electroreduction of nitrate (NO3-) to value-added ammonia (NH3) provides an alternative to NH3 production industry and remediation of NO3--containing wastewater.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	29-32
34509834-5	2022	The nitrate mass fraction increased during the three haze episodes, with nitrate accounting for 27-33% of PM1 mass.	Nitrates	73-80	transmembrane protein 11	Homo sapiens	106-109
34343879-1	2022	Electroreduction of nitrate (NO3-) to value-added ammonia (NH3) provides an alternative to NH3 production industry and remediation of NO3--containing wastewater.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	134-137
34914357-1	2022	Electrocatalytic nitrate (NO3-) reduction to N2 via atomic hydrogen (H*) is a promising approach for advanced water treatment.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
34923327-1	2022	The present research reports the level of nitrate (NO3-), associated health risks and possible sources of contamination in groundwater from south India.	Nitrates	42-49	NBL1, DAN family BMP antagonist	Homo sapiens	51-54
34426281-2	2022	The scope of this work is the development of a mechanistic biokinetic model, based on first principles and a robust thermodynamic basis, to provide a theoretical accurate description of a MET system that would treat water contaminated with nitrate, the most common aquifer water pollutant, in absence of external electron donors.	Nitrates	240-247	SAFB like transcription modulator	Homo sapiens	188-191
34940921-10	2022	There was an increase in nitrate levels of CSF and CSF/plasma ratio of nitrate in patients with PD and LID compared to the healthy controls.	Nitrates	25-32	colony stimulating factor 2	Homo sapiens	43-46
34940921-10	2022	There was an increase in nitrate levels of CSF and CSF/plasma ratio of nitrate in patients with PD and LID compared to the healthy controls.	Nitrates	71-78	colony stimulating factor 2	Homo sapiens	51-54
34814021-8	2022	In case of NaOH as the electrolyte, the single-pass nitrate removal efficiency, selectivity to nitrogen formation and nitrate removal rate was 90.66%, 96.40% and 1.47 x 10-3 mmol min-1 cm-2, respectively.	Nitrates	52-59	CD59 molecule (CD59 blood group)	Homo sapiens	179-189
34814021-8	2022	In case of NaOH as the electrolyte, the single-pass nitrate removal efficiency, selectivity to nitrogen formation and nitrate removal rate was 90.66%, 96.40% and 1.47 x 10-3 mmol min-1 cm-2, respectively.	Nitrates	118-125	CD59 molecule (CD59 blood group)	Homo sapiens	179-189
34974023-3	2022	Ice cores contain records of nitrogen species of nitrate (NO3-) and ammonium (NH4+), hence provide valuable long-term data to study past variations of atmospheric nitrogen deposition.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	58-61
34967938-7	2021	RESULTS: Administration of Klotho protein resulted in mitigation of injury, decreased level of NOX2 and NOX4, reduced generation of ROS/RNS and hydrogen peroxide (H2O2), decreased expression of inducible NOS and limited production of nitrates/nitrites in cells under I/R.	Nitrates	234-242	klotho	Homo sapiens	27-33
34968494-11	2022	Inorganic nitrites and nitrates can decrease the risk for osteoporotic fracture probably directly by decreasing osteoclast activity, decreasing fat accumulation in the marrow cavity, increasing osteoblast activity, and increasing bone perfusion or indirectly, by improving hyperglycemia, insulin resistance, and reducing body weight.	Nitrates	23-31	insulin	Homo sapiens	288-295
34919376-6	2021	Owing to the strong adsorption of nitrate on Fe0 active sites generated via topotactic conversion and in situ electroreduction, 2D Fe-cyano electrocatalyst exhibits high catalytic activity with a yield rate of 42.1 mg h-1 mgcat-1 and a Faradaic efficiency of over 90% toward NH3 production at -0.5 V (vs reversible hydrogen electrode, RHE).	Nitrates	34-41	factor interacting with PAPOLA and CPSF1	Homo sapiens	335-338
34467905-7	2021	In comparison with a control, the Kyoto Encyclopedia of Genes and Genomes analysis showed that wastewater salinity weakened the functional gene level of MBR microbial flora, and the enzyme key to the assimilation nitrate reduction changed from nitrate reductase to assimilation nitrate reductase.	Nitrates	213-220	translocator protein	Homo sapiens	153-156
34467905-7	2021	In comparison with a control, the Kyoto Encyclopedia of Genes and Genomes analysis showed that wastewater salinity weakened the functional gene level of MBR microbial flora, and the enzyme key to the assimilation nitrate reduction changed from nitrate reductase to assimilation nitrate reductase.	Nitrates	278-285	translocator protein	Homo sapiens	153-156
34927377-1	2022	Nitrate (NO 3 - ) as a common pollutant under groundwater causes drinking water safety problems and seriously endangers people"s health.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-13
34927377-2	2022	Electrochemistry reduction nitrate to ammonia under ambient condition is a green and significant route to reduce the concentration of NO 3 - and produce ammonia (NH 3 ), known as a complement to the Haber-Bosch reaction.	Nitrates	27-34	NBL1, DAN family BMP antagonist	Homo sapiens	134-138
34870671-1	2021	Nitrogen speciation, i.e. distinguishing nitrate (NO3-) and ammonium (NH4+), is commonly undertaken in soil studies, but has not been conducted extensively for lichens.	Nitrates	41-48	NBL1, DAN family BMP antagonist	Homo sapiens	50-53
34536740-1	2021	Nitrate (NO3-) leaching has negative human and environmental health consequences that can be attributed to and mitigated by agricultural decision making.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34618055-1	2021	Nitrate (NO3) assimilation and signaling regulate plant growth through the relevant function of the transcription factor NIN-like Protein7 (NLP7).	Nitrates	0-7	NIN like protein 7	Arabidopsis thaliana	121-138
34912897-9	2021	Methanolic extract of S. kurramense decreased CCl4-induced hepatotoxicity by increasing the antioxidant status and reducing H2O2 and nitrate content generation as well as reducing DNA damage.	Nitrates	133-140	C-C motif chemokine ligand 4	Rattus norvegicus	46-50
34524462-0	2021	STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.	Nitrates	32-39	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	0-5
34524462-0	2021	STOP1 activates NRT1.1-mediated nitrate uptake to create a favorable rhizospheric pH for plant adaptation to acidity.	Nitrates	32-39	nitrate transporter 1.1	Arabidopsis thaliana	16-22
34524462-3	2021	Here, we showed that in the roots of Arabidopsis thaliana, the C2H2-type transcription factor STOP1 in the nucleus was enriched by low pH in a nitrate-independent manner, with the spatial expression pattern of NITRATE TRANSPORTER 1.1 (NRT1.1) established by low pH required the action of STOP1.	Nitrates	143-150	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	94-99
34524462-5	2021	Molecular assays revealed that STOP1 directly bound to the promoter of NRT1.1 to activate its transcription in response to low pH, thus upregulating its nitrate uptake.	Nitrates	153-160	C2H2 and C2HC zinc fingers superfamily protein	Arabidopsis thaliana	31-36
34524462-5	2021	Molecular assays revealed that STOP1 directly bound to the promoter of NRT1.1 to activate its transcription in response to low pH, thus upregulating its nitrate uptake.	Nitrates	153-160	nitrate transporter 1.1	Arabidopsis thaliana	71-77
34618055-1	2021	Nitrate (NO3) assimilation and signaling regulate plant growth through the relevant function of the transcription factor NIN-like Protein7 (NLP7).	Nitrates	0-7	NIN like protein 7	Arabidopsis thaliana	140-144
34225116-7	2021	STL addition enhanced nitrification at high temperatures during composting, thus increasing the nitrate content of compost by 2-10 times compared with that of the control group (using tap water as a moisture conditioning agent).	Nitrates	96-103	RNF217 antisense RNA 1 (head to head)	Homo sapiens	0-3
34926901-1	2021	Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34926901-1	2021	Nitrate (NO3 -) contamination is becoming a major concern due to the negative effects of an excessive NO3 - presence in water which can have detrimental effects on human health.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
34273081-1	2021	Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34273081-1	2021	Nitrate (NO3-) contamination has become a dominant international problem in the aquatic environment, so identifying the sources and transformations of NO3- is the basis for improving water quality.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	151-154
34467886-1	2021	The annual mean PM2.5 mass concentration has decreased because of the stringent emission controls implemented in Beijing, China in recent years, whereas the nitrate NO3- mass fraction in PM2.5 increases gradually.	Nitrates	157-164	NBL1, DAN family BMP antagonist	Homo sapiens	165-168
33342321-6	2021	mC2 sponges exhibited superior in-vitro drug release profiles where ~100% of tenoxicam released within 5 min for fast pain relief with a more prolonged miconazole nitrate release.	Nitrates	163-170	complement component 2 (within H-2S)	Mus musculus	0-3
34328901-0	2021	Mix-cultured aerobic denitrifying bacterial communities reduce nitrate: Novel insights in micro-polluted water treatment at lower temperature.	Nitrates	63-70	Mix paired-like homeobox	Homo sapiens	0-3
34486076-7	2021	We selected seven homologs containing conserved features of AtRIN4, including two NOI (Nitrate induced) domains, each containing a predicted cleavage site for AvrRpt2, and a C-terminal palmitoylation site predicted to mediate membrane tethering of the proteins.	Nitrates	87-94	RPM1 interacting protein 4	Arabidopsis thaliana	60-66
34758438-4	2021	The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
34758438-4	2021	The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
34758438-4	2021	The correlations between the nitrate (NO3-) concentrations and isotopic compositions (delta15N/delta18O-NO3-) indicated the pelagic NO3- loads were largely regulated by mixing between precipitation and sewage.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	132-135
34842136-6	2021	Compared to wild-type mice, isolated perfused kidneys of C451A-ERalpha mice revealed a decreased flow-mediated nitrate production and an increased H2O2 production.	Nitrates	111-118	estrogen receptor 1 (alpha)	Mus musculus	63-70
34856430-6	2021	A new conversion mechanism was proposed that CN- was activated into electron-deficient cyanide radical ( CN) by  OH, and then the  CN intermediates reacted with  O2- via nucleophilic addition to quickly form NO3-, preventing the formation of CNO- and promoting the mineralization of cyanide.	Nitrates	208-212	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	242-245
34352479-3	2021	Moreover, the hydrochemical parameters and the delta15N and delta18O values of nitrate were employed to quantitatively trace the sources and biochemical transformation of NO3-, and the contribution ratios of different NO3- sources were estimated using the stable isotope analysis in R based on the Bayesian model.	Nitrates	79-86	NBL1, DAN family BMP antagonist	Homo sapiens	171-174
34800458-7	2022	In wintertime, maximum nitrate concentrations (up to 73 mg NO3/L) and loads (up to 1300 t NO3/a; up to 98% in winter) correlate with high-flow conditions.	Nitrates	23-30	NBL1, DAN family BMP antagonist	Homo sapiens	59-64
34767107-6	2021	Nitrate concentrations in the rural and urban areas were within 0.4-137 mg/L NO3- and 2.9-209 mg/L NO3-, respectively.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	77-80
34252777-4	2021	DON<1kDa dominated the DON pool and significantly correlated inversely with DIN, indicating the DON<1kDa mineralized into nitrate.	Nitrates	122-129	neuregulin 2	Homo sapiens	96-101
34328950-1	2021	Nitrate (NO3) radical is an important oxidant in the atmosphere as it regulates the NOx budget and impacts secondary pollutant formation.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34328950-5	2021	Specifically, for the N2O5 uptake, the rapid increase in NO3 production, or to some extent, NO3 oxidation capacity, far outweighed the negative shift effect, leading to a net enhancement of N2O5 uptake in winter, which indicates that the action policy implemented led to an adverse effect on particulate nitrate formation via N2O5 uptake in winter.	Nitrates	304-311	NBL1, DAN family BMP antagonist	Homo sapiens	57-60
34328950-5	2021	Specifically, for the N2O5 uptake, the rapid increase in NO3 production, or to some extent, NO3 oxidation capacity, far outweighed the negative shift effect, leading to a net enhancement of N2O5 uptake in winter, which indicates that the action policy implemented led to an adverse effect on particulate nitrate formation via N2O5 uptake in winter.	Nitrates	304-311	NBL1, DAN family BMP antagonist	Homo sapiens	92-95
34767107-6	2021	Nitrate concentrations in the rural and urban areas were within 0.4-137 mg/L NO3- and 2.9-209 mg/L NO3-, respectively.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	99-102
34677563-1	2021	High-quality CoP nanorings (CoP NRs) are easily achieved using a phosphorating treatment of CoOOH nanorings, and reveal high activity towards the hydrogen evolution reaction and the nitrate electrocatalytic reduction reaction due to substantial coordinately unsaturated active sites, a high surface area, and available mass transfer pathways.	Nitrates	182-189	caspase recruitment domain family member 16	Homo sapiens	13-16
34764268-8	2021	These inhibitory impacts of nitrate on symbiosis occur in a Nlp1 and Nlp4 dependent manner and contrast with the positive influence of nitrate on cytokinin biosynthesis that occurs in species that do not form symbiotic root nodules.	Nitrates	28-35	NLP1	Lotus japonicus	60-64
34618046-0	2021	CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth.	Nitrates	49-56	calmodulin-like 38	Arabidopsis thaliana	0-18
34618046-0	2021	CALMODULIN-LIKE-38 and PEP1 RECEPTOR 2 integrate nitrate and brassinosteroid signals to regulate root growth.	Nitrates	49-56	PEP1 receptor 2	Arabidopsis thaliana	23-38
34523752-6	2021	Sequence analysis revealed three sub-types of AtNPF6.3 orthologs based on their predicted substrate-binding residues: A (chloride selective), B (nitrate selective), and C (legume specific).	Nitrates	145-152	nitrate transporter 1.1	Arabidopsis thaliana	46-54
34618046-3	2021	Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN).	Nitrates	229-236	calmodulin-like 38	Arabidopsis thaliana	19-37
34618046-3	2021	Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN).	Nitrates	229-236	calmodulin-like 38	Arabidopsis thaliana	39-44
34618046-3	2021	Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN).	Nitrates	229-236	PEP1 receptor 2	Arabidopsis thaliana	106-121
34618046-3	2021	Here, we show that CALMODULIN-LIKE-38 (CML38), a calmodulin-like protein, specifically interacts with the PEP1 RECEPTOR 2 (PEPR2), and negatively regulates root elongation in Arabidopsis (Arabidopsis thaliana) in response to low nitrate (LN).	Nitrates	229-236	PEP1 receptor 2	Arabidopsis thaliana	123-128
34618046-4	2021	CML38 and PEPR2 are transcriptionally induced by treatments of exogenous nitrate and BR.	Nitrates	73-80	calmodulin-like 38	Arabidopsis thaliana	0-5
34618046-4	2021	CML38 and PEPR2 are transcriptionally induced by treatments of exogenous nitrate and BR.	Nitrates	73-80	PEP1 receptor 2	Arabidopsis thaliana	10-15
34649677-0	2021	What is the role of the nitrate reductase (euknr) gene in fungi that live in nitrate-free environments?	Nitrates	77-84	AWN88_RS04670	Agrobacterium tumefaciens	24-41
34506950-1	2021	Oral microbiota dysbiosis, concomitant with decreased abundance of nitrate (NO3-)-reducing bacteria, oral net nitrite (NO2-) production, and reduced nitric oxide ( NO) bioactivity, is associated with the development of cardiometabolic disorders.	Nitrates	67-74	NBL1, DAN family BMP antagonist	Homo sapiens	76-79
34656860-0	2021	The Arabidopsis protein NPF6.2/NRT1.4 is a plasma membrane nitrate transporter and a target of protein kinase CIPK23.	Nitrates	59-66	Major facilitator superfamily protein	Arabidopsis thaliana	24-30
34656860-0	2021	The Arabidopsis protein NPF6.2/NRT1.4 is a plasma membrane nitrate transporter and a target of protein kinase CIPK23.	Nitrates	59-66	CBL-interacting protein kinase 23	Arabidopsis thaliana	110-116
34656860-4	2021	Here we show that NPF6.2/NRT1.4, a protein that gates nitrate accumulation at the leaf petiole of Arabidopsis thaliana, also affects the root/shoot distribution of potassium.	Nitrates	54-61	Major facilitator superfamily protein	Arabidopsis thaliana	18-24
34656860-5	2021	We demonstrate that NPF6.2/NRT1.4 is a plasma membrane nitrate transporter phosphorylated at threonine-98 by the CIPK23 protein kinase that is a regulatory hub for nitrogen and potassium nutrition.	Nitrates	55-62	Major facilitator superfamily protein	Arabidopsis thaliana	20-26
34656860-5	2021	We demonstrate that NPF6.2/NRT1.4 is a plasma membrane nitrate transporter phosphorylated at threonine-98 by the CIPK23 protein kinase that is a regulatory hub for nitrogen and potassium nutrition.	Nitrates	55-62	CBL-interacting protein kinase 23	Arabidopsis thaliana	113-119
34558591-1	2021	A procedure for the formation of a nitrate-encapsulating tripalladium(II) cage via self-assembly of Pd(NO3)2 with 1,3-bis(dimethyl(pyridin-4-yl)silyl)propane (L) was developed.	Nitrates	35-42	NBL1, DAN family BMP antagonist	Homo sapiens	103-106
34542810-0	2021	Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.	Nitrates	0-7	DNA damage inducible transcript 4	Homo sapiens	81-86
34542810-0	2021	Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.	Nitrates	0-7	AKT serine/threonine kinase 1	Homo sapiens	87-90
34542810-7	2021	However, nitrate could increase cisplatin chemosensitivity, reduce its REDD1 expression, and attenuate AKT signaling activation in OSCC cells.	Nitrates	9-16	DNA damage inducible transcript 4	Homo sapiens	71-76
34542810-7	2021	However, nitrate could increase cisplatin chemosensitivity, reduce its REDD1 expression, and attenuate AKT signaling activation in OSCC cells.	Nitrates	9-16	AKT serine/threonine kinase 1	Homo sapiens	103-106
34558591-2	2021	The self-assembly reaction initially produces spiro-type macrocycles, PdL2, and finally results in transformation into a nitrate-encapsulated cage, ((NO3)@Pd3L6), in the mother liquor.	Nitrates	121-128	programmed cell death 1 ligand 2	Homo sapiens	70-74
34558591-2	2021	The self-assembly reaction initially produces spiro-type macrocycles, PdL2, and finally results in transformation into a nitrate-encapsulated cage, ((NO3)@Pd3L6), in the mother liquor.	Nitrates	121-128	NBL1, DAN family BMP antagonist	Homo sapiens	150-153
34657263-1	2022	High concentration of nitrate (NO3-) in groundwater is a major concern because of its complex origin and harmful effects on human health.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
34182389-3	2021	This study examined both the long-term trends in atmospheric nitrogen (N) deposition from the 1990s to the 2010s and the response of stream water nitrate (NO3-) leaching from forested areas in western Japan.	Nitrates	146-153	NBL1, DAN family BMP antagonist	Homo sapiens	155-158
34581118-14	2021	The delineation of NO3-type waters, especially the low-TDS type, is helpful for identifying groundwaters posing greater risks for human activities, and those with low nitrate concentrations but potential pollution risk, which is of great significance in the prevention and control of groundwater pollution.	Nitrates	167-174	NBL1, DAN family BMP antagonist	Homo sapiens	19-22
34147777-3	2021	The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively.	Nitrates	30-37	solute carrier family 9 member B1	Homo sapiens	131-137
34147777-3	2021	The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively.	Nitrates	30-37	solute carrier family 9 member B1	Homo sapiens	188-199
34147777-3	2021	The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively.	Nitrates	30-37	solute carrier family 9 member B1	Homo sapiens	308-314
34147777-3	2021	The results revealed that the nitrate accumulation at 0-100 cm, 100-200 cm, 200-300 cm, and >300 cm were 504, 390, 349, and 244 kg N ha-1, with accumulation rates of 62, 54, 19, and 16 kg N ha-1 yr-1 for plastic greenhouse vegetables (PG); for open field vegetables (OF), they were 264, 217, 228, and 242 kg N ha-1 with accumulation rates of 26, 24, 18, and 10 kg N ha-1 yr-1, respectively.	Nitrates	30-37	solute carrier family 9 member B1	Homo sapiens	364-375
34643825-0	2021	Long-term variation of nitrate in the East Sea, Korea.	Nitrates	23-30	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
34643825-7	2021	Second, decrease in the nitrate flux of the Nakdong River"s estuary due to the construction of the estuary dam and sewer treatment plant could also be a factor for the nitrate decrease in the East Sea.	Nitrates	24-31	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	197-200
34643825-7	2021	Second, decrease in the nitrate flux of the Nakdong River"s estuary due to the construction of the estuary dam and sewer treatment plant could also be a factor for the nitrate decrease in the East Sea.	Nitrates	168-175	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	197-200
34643825-9	2021	The amount of nitrate runoff reduced by the anthropogenic activities influenced the nitrate levels over a long period by the flow of currents in the East Sea.	Nitrates	14-21	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	154-157
34643825-9	2021	The amount of nitrate runoff reduced by the anthropogenic activities influenced the nitrate levels over a long period by the flow of currents in the East Sea.	Nitrates	84-91	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	154-157
34180337-8	2021	The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition.	Nitrates	183-190	AGAMOUS-like 44	Arabidopsis thaliana	36-40
34677535-0	2021	A Study to Enhance the Nitrate-Nitrogen Removal Rate without Dismantling the NF Module by Building a PFSA Ionomer-Coated NF Module.	Nitrates	23-30	neurofascin	Homo sapiens	121-123
34180337-8	2021	The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition.	Nitrates	183-190	nitrate transporter 1.1	Arabidopsis thaliana	153-159
34180337-8	2021	The arabidopsis nitrate regulated1 (ANR1) is induced from the endosome by the Ca2+-CPKs-NLPs signaling pathway activated by the unphosphorylated form of NRT1.1 (NRT1.1 T101A) at high nitrate condition.	Nitrates	183-190	nitrate transporter 1.1	Arabidopsis thaliana	161-165
34228952-9	2021	Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants.	Nitrates	52-59	transforming growth factor beta 1	Homo sapiens	23-28
34228952-9	2021	Moreover, the catalyst D-Pd1/Sn1 reached a complete nitrate removal in the municipal wastewater treatment plant effluent water within 3 h. The results provide a prospect for denitrification in biological wastewater treatment plants.	Nitrates	52-59	solute carrier family 38 member 3	Homo sapiens	29-32
34087531-1	2021	Transport and transformation processes of nitrogen in the soil are an essential part of understanding the relationship between agricultural input and nitrate (NO3-) concentrations in groundwater.	Nitrates	150-157	NBL1, DAN family BMP antagonist	Homo sapiens	159-162
34388487-9	2021	Our results suggested that the leaf litter treatment was preferential for nitrate reduction over the mud deposit treatment, with a higher NO3- reduction rate and less NH4+ accumulation during the complete BS process.	Nitrates	74-81	NBL1, DAN family BMP antagonist	Homo sapiens	138-141
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	0-7	solute carrier family 17 member 5	Homo sapiens	23-29
34679685-1	2021	The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR).	Nitrates	17-24	insulin	Homo sapiens	117-124
34679685-6	2021	Plasma nitrate, but not nitrite, correlated positively with vegetable intake (r = 0.38, p = 0.018) and was inversely associated with HOMA-IR (r = -0.44, p = 0.006), BMI (r = -0.35, p = 0.028), GGT (r = -0.37, p = 0.019) and CRP (r = -0.34, p = 0.034).	Nitrates	7-14	gamma-glutamyltransferase light chain family member 3	Homo sapiens	193-196
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	0-7	solute carrier family 17 member 5	Homo sapiens	115-121
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	107-114	solute carrier family 17 member 5	Homo sapiens	23-29
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	107-114	solute carrier family 17 member 5	Homo sapiens	115-121
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	153-160	solute carrier family 17 member 5	Homo sapiens	23-29
34581269-5	2021	Nitrate could increase sialin expression, a nitrate transporter expressed in the parotid gland, making the nitrate-sialin feedback loop that facilitates nitrate influx into cells for maintaining cell proliferation and inhibiting apoptosis.	Nitrates	153-160	solute carrier family 17 member 5	Homo sapiens	115-121
34581269-6	2021	Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue.	Nitrates	13-20	epidermal growth factor receptor	Homo sapiens	57-89
34581269-6	2021	Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue.	Nitrates	13-20	epidermal growth factor receptor	Homo sapiens	91-95
34581269-6	2021	Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue.	Nitrates	13-20	protein tyrosine kinase 2 beta	Homo sapiens	97-113
34581269-6	2021	Furthermore, nitrate enhanced cell proliferation via the epidermal growth factor receptor (EGFR)-protein kinase B (AKT)-mitogen-activated protein kinase (MAPK) signaling pathway in irradiated parotid gland tissue.	Nitrates	13-20	AKT serine/threonine kinase 1	Homo sapiens	115-118
34581269-7	2021	Collectively, nitrate effectively prevented IR-induced xerostomia via the EGFR-AKT-MAPK signaling pathway.	Nitrates	14-21	epidermal growth factor receptor	Homo sapiens	74-78
34581269-7	2021	Collectively, nitrate effectively prevented IR-induced xerostomia via the EGFR-AKT-MAPK signaling pathway.	Nitrates	14-21	AKT serine/threonine kinase 1	Homo sapiens	79-82
34129038-3	2021	Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana.	Nitrates	197-204	ILI1 binding bHLH 1	Arabidopsis thaliana	127-131
34129038-3	2021	Here, we showed that the growth-related transcription factors HOMOLOG OF BRASSINOSTEROID ENHANCED EXPRESSION2 INTERACTING WITH IBH1 (HBI1) and its three closest homologs (HBIs) positively regulate nitrate signaling in Arabidopsis thaliana.	Nitrates	197-204	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	133-137
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	27-34	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-4
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	27-34	Plant regulator RWP-RK family protein	Arabidopsis thaliana	43-47
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	27-34	NIN like protein 7	Arabidopsis thaliana	52-56
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	89-96	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	0-4
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	89-96	Plant regulator RWP-RK family protein	Arabidopsis thaliana	43-47
34129038-4	2021	HBI1 is rapidly induced by nitrate through NLP6 and NLP7, which are master regulators of nitrate signaling.	Nitrates	89-96	NIN like protein 7	Arabidopsis thaliana	52-56
34129038-7	2021	Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2.	Nitrates	0-7	NIN like protein 7	Arabidopsis thaliana	54-58
34129038-7	2021	Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2.	Nitrates	94-101	NIN like protein 7	Arabidopsis thaliana	54-58
34129038-7	2021	Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2.	Nitrates	94-101	cationic amino acid transporter 2	Arabidopsis thaliana	146-150
34129038-7	2021	Nitrate treatment induces the nuclear localization of NLP7, whereas such promoting effects of nitrate are significantly impaired in the hbi-q and cat2 cat3 mutants, which accumulate high levels of H2O2.	Nitrates	94-101	catalase 3	Arabidopsis thaliana	151-155
34129038-8	2021	These results demonstrate that HBI-mediated ROS homeostasis regulates nitrate signal transduction through modulating the nucleocytoplasmic shuttling of NLP7.	Nitrates	70-77	NIN like protein 7	Arabidopsis thaliana	152-156
34528820-0	2021	Genome Sequence of Linnemannia hyalina Strain SCG-10, a Cold-Adapted and Nitrate-Reducing Fungus Isolated from Cornfield Soil in Minnesota, USA.	Nitrates	73-80	stathmin 2	Homo sapiens	46-52
34549237-1	2021	Through the combination of X-ray structure analysis and density functional theory (DFT) theoretical calculations at the B3LYP-D3/def2-TZVP level of theory, we designed and investigated two novel host units for the recognition of neutral (e.g. halobenzenes) and charged (e.g. chloride and nitrate) guests inspired by a glutamate carboxypeptidase II (GCPII) system and its inhibitors.	Nitrates	288-295	folate hydrolase 1	Homo sapiens	318-347
34549237-1	2021	Through the combination of X-ray structure analysis and density functional theory (DFT) theoretical calculations at the B3LYP-D3/def2-TZVP level of theory, we designed and investigated two novel host units for the recognition of neutral (e.g. halobenzenes) and charged (e.g. chloride and nitrate) guests inspired by a glutamate carboxypeptidase II (GCPII) system and its inhibitors.	Nitrates	288-295	folate hydrolase 1	Homo sapiens	349-354
34528820-1	2021	We report here the genome sequence of Linnemannia hyalina strain SCG-10, a cold-adapted and nitrate-reducing fungus isolated from soil.	Nitrates	92-99	stathmin 2	Homo sapiens	65-71
34357701-0	2021	Nitrate triggered phosphoproteome changes and a PIN2 phosphosite modulating root system architecture.	Nitrates	0-7	Auxin efflux carrier family protein	Arabidopsis thaliana	48-52
34519758-0	2021	Electrocatalytic nitrate reduction with Co-based catalysts: comparison of DIM, TIM and cyclam ligands.	Nitrates	17-24	Rho guanine nucleotide exchange factor 5	Homo sapiens	79-82
34357701-6	2021	The phosphorylation profile of NITRATE TRANSPORTER 1.1 (NRT1.1) mutant plants was significantly altered as compared to wild-type plants, confirming its key role in nitrate signaling pathways that involves phosphorylation changes.	Nitrates	164-171	nitrate transporter 1.1	Arabidopsis thaliana	31-54
34357701-6	2021	The phosphorylation profile of NITRATE TRANSPORTER 1.1 (NRT1.1) mutant plants was significantly altered as compared to wild-type plants, confirming its key role in nitrate signaling pathways that involves phosphorylation changes.	Nitrates	164-171	nitrate transporter 1.1	Arabidopsis thaliana	56-62
34357701-8	2021	We validated a new phosphorylation site in PIN2 and provide evidence that it functions in primary and lateral root growth responses to nitrate.	Nitrates	135-142	Auxin efflux carrier family protein	Arabidopsis thaliana	43-47
34075592-3	2021	This raises the question of why nitrate may or may not be present in phloem sap, why its concentration is generally kept low, and whether plant shoot-root nutrient cycling also involves nitrate.	Nitrates	32-39	SH2 domain containing 1A	Homo sapiens	76-79
34089542-3	2021	By investigating moss N contents and delta15 N values in southwestern China in 1954-1964, 1970-1994, and 2005-2015, we reconstructed fluxes and source contributions of atmospheric ammonium (NH4 + ) and nitrate (NO3 - ) deposition and their historical changes.	Nitrates	202-209	NBL1, DAN family BMP antagonist	Homo sapiens	211-214
34155644-5	2021	Also, dissolution - being microbially-mediated - would be buffered by the presence of nitrate (NO3 - ), which is a preferable electron acceptor than Fe and Mn in microbial reactions.	Nitrates	86-93	NBL1, DAN family BMP antagonist	Homo sapiens	95-98
34147727-8	2021	Nitrate decrease MDA by reducing the activities of superoxide dismutase, peroxidase, and catalase in root of the N-efficient genotype.	Nitrates	0-7	peroxidase A2	Brassica napus	73-83
34147727-8	2021	Nitrate decrease MDA by reducing the activities of superoxide dismutase, peroxidase, and catalase in root of the N-efficient genotype.	Nitrates	0-7	catalase-3-like	Brassica napus	89-97
34198052-5	2021	At long-term, nitrate reductase (SlNR) and nitrite reductase (SlNIR) expression were not significantly different between nitrate treatments in RO, while significantly down-regulated under nitrate limiting treatment in UC82.	Nitrates	188-195	nitrite reductase	Solanum lycopersicum	43-60
34477653-3	2021	In this study, a novel zeolitic imidazolate framework-8 film engineered bismuth nanosheet electrocatalyst (ZIF-8/Bi-CC) was designed and synthesized for the electrochemical reduction of nitrate.	Nitrates	186-193	Bicaudal C	Drosophila melanogaster	113-118
34074412-5	2021	In order to demonstrate applicability of the method, label free SERS measurements of nitrate ion was performed on the proposed sensing platform.	Nitrates	85-92	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	64-68
34578546-2	2021	In this paper, Sm3+ and Nd3+ co-doped CeO2 (SNDC) and pure CeO2 are synthesized via glycine-nitrate process (GNP) and the electro-chemical properties of the nanocrystalline structure electrolyte are investigated using complementary techniques.	Nitrates	92-99	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	24-27
34477653-7	2021	More importantly, the final nitrate removal rate of ZIF-8/Bi-CC was close to 90% after 5 h when treating actual garbage fly ash wastewater, the NITRR efficiency stability and the obtained product were confirmed by five electrochemical cycles.	Nitrates	28-35	Bicaudal C	Drosophila melanogaster	58-63
34497626-0	2021	NRT1.1 Dual-Affinity Nitrate Transport/Signalling and its Roles in Plant Abiotic Stress Resistance.	Nitrates	21-28	immunoglobulin superfamily member 9	Homo sapiens	0-4
34410136-1	2021	Nitrate (NO3-) reduction reaction (NtRR) is considered as a green alternative method for the conventional method of NH3 synthesis (Haber-Bosch process), which is known as a high energy consuming and large CO2 emitting process.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34440751-7	2021	The current literature suggests that ROS/RNS nitrate proNGF and reduce the expression of the proNGF receptor tropomyosin-related kinase A (TrkA), disrupting its downstream survival signalling.	Nitrates	45-52	neurotrophic receptor tyrosine kinase 1	Homo sapiens	139-143
34408222-1	2021	Nitrate (NO3-) pollution is a serious global problem, and the quantitative analysis of its sources contributions is essential for devising effective water-related environmental-protection policies.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
34421841-1	2021	Woodchip bioreactors are increasingly used to remove nitrate (NO3 -) from agricultural drainage water in order to protect aquatic ecosystems from excess nitrogen.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
34161745-8	2021	The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking.	Nitrates	4-11	delta like non-canonical Notch ligand 1	Homo sapiens	72-78
34161745-8	2021	The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking.	Nitrates	4-11	delta like non-canonical Notch ligand 1	Homo sapiens	125-131
34161745-8	2021	The nitrate group showed significantly increased serum nitrate/nitrite (Delta1.32muM), increased brachial and popliteal FMD (Delta1.3% and Delta1.7%, respectively), reduced peripheral and central systolic BP (Delta-4.7mmHg and Delta-8.2mmHg, respectively), increased maximal walking distance (Delta92.7m) and time (Delta56.3s), and reduced deoxygenated hemoglobin during walking.	Nitrates	4-11	delta like non-canonical Notch ligand 1	Homo sapiens	139-145
34124878-0	2021	Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction.	Nitrates	117-124	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	22-29
34309015-6	2021	In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function.	Nitrates	114-121	xanthine dehydrogenase	Mus musculus	176-199
34309015-6	2021	In mouse models of cardiac remodelling, we also show that restoration of circulating nitrite levels using dietary nitrate improves endothelial dysfunction through targeting of xanthine oxidoreductase (XOR)-driven H2 O2 and superoxide, and reduces cardiac fibrosis through NO-mediated block of SMAD-phosphorylation leading to improvements in cardiac structure and function.	Nitrates	114-121	xanthine dehydrogenase	Mus musculus	201-204
34264986-10	2021	By adding supplementary LED lamps into the EAS, the soluble sugar content of lettuce increased by 72.14% and the nitrate content of lettuce decreased by 21.51%.	Nitrates	113-120	small integral membrane protein 10 like 2A	Homo sapiens	24-27
34276717-0	2021	Growth Performance Can Be Increased Under High Nitrate and High Salt Stress Through Enhanced Nitrate Reductase Activity in Arabidopsis Anthocyanin Over-Producing Mutant Plants.	Nitrates	47-54	nitrate reductase 1	Arabidopsis thaliana	93-110
34276717-3	2021	However, excessive nitrogen use has an enormous negative impact on ecosystems and human health through the emission of intense greenhouse gases, such as nitric oxide derived from the nitrate (NO3 -) assimilation cascade.	Nitrates	183-190	NBL1, DAN family BMP antagonist	Homo sapiens	192-195
34209142-1	2021	The objective of the study was to gather insight into the metabolism of lead-removing microorganisms, coupled with Pb(II) removal, biomass viability and nitrate concentrations for Pb(II) bioremoval using an industrially obtained microbial consortium.	Nitrates	153-160	submaxillary gland androgen regulated protein 3B	Homo sapiens	180-186
34235267-1	2021	A combined technique of production and storage of ammonia (NH3) from electroreduction of nitrate (NO3 -) through one material is highly desirable but remains a huge challenge.	Nitrates	89-96	NBL1, DAN family BMP antagonist	Homo sapiens	98-101
34124878-0	2021	Synergistic Effect of Co(III) and Co(II) in a 3D Structured Co3O4/Carbon Felt Electrode for Enhanced Electrochemical Nitrate Reduction Reaction.	Nitrates	117-124	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-40
34207422-1	2021	Denitrifying woodchip bioreactors (WBR), which aim to reduce nitrate (NO3-) pollution from agricultural drainage water, are less efficient when cold temperatures slow down the microbial transformation processes.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Homo sapiens	70-73
34086442-4	2021	The uptake process of NO2 on OA gives HONO as a reaction product, and the highest HONO production was observed upon the heterogeneous reaction of NO2 with OA in the presence of nitrate (NO3-) ions.	Nitrates	177-184	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
34208733-1	2021	A direct, reagent-free, ultraviolet spectroscopic method for the simultaneous determination of nitrate (NO3-), nitrite (NO2-), and salinity in seawater is presented.	Nitrates	95-102	NBL1, DAN family BMP antagonist	Homo sapiens	104-107
34114114-11	2021	With a combined change in climate and land cover, the annual nitrate concentrations are expected to increase by + 19.7% and + 17.9%, under RCP 4.5 and RCP 8.5, respectively.	Nitrates	61-68	CGRP receptor component	Homo sapiens	139-142
34198661-4	2021	The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise.	Nitrates	14-21	catalase	Homo sapiens	116-124
34198661-4	2021	The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise.	Nitrates	14-21	mitofusin 2	Homo sapiens	172-183
34198661-4	2021	The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1alpha in PBMCs after exercise.	Nitrates	14-21	PPARG coactivator 1 alpha	Homo sapiens	188-197
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Nitrates	195-202	catalase	Homo sapiens	23-31
34198661-5	2021	The gene expression of catalase and TNFalpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake.	Nitrates	195-202	tumor necrosis factor	Homo sapiens	36-44
34114114-11	2021	With a combined change in climate and land cover, the annual nitrate concentrations are expected to increase by + 19.7% and + 17.9%, under RCP 4.5 and RCP 8.5, respectively.	Nitrates	61-68	CGRP receptor component	Homo sapiens	151-154
34275783-1	2021	To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF).	Nitrates	56-63	energy homeostasis associated	Homo sapiens	83-90
34193742-3	2021	However, NO is divided into two fractions, nitrite (NO2) and nitrate (NO3), which appear to play different roles in epileptogenesis.	Nitrates	61-68	NBL1, DAN family BMP antagonist	Mus musculus	70-73
34275783-1	2021	To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF).	Nitrates	56-63	natriuretic peptide B	Homo sapiens	95-120
34275783-1	2021	To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF).	Nitrates	56-63	natriuretic peptide B	Homo sapiens	122-125
34264555-3	2021	The aim of the work was to study the levels of nitrate contamination of CP and assess the associated risk to the health of children and adults in the Baikal Region.	Nitrates	47-54	ceruloplasmin	Homo sapiens	72-74
35576711-1	2022	Researchers have long been committed to identify nitrate sources in groundwater and to develop an advanced technique for its remediation because better apply remediation solution and management of water quality is highly dependent on the identification of the NO3- sources contamination in water.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	260-263
35472551-8	2022	CSCF exhibited good photocatalytic degradation performance in a broad range of ionic strengths, in the presence of common coexisting ions including Cl-, NO3- and SO42-, in a wide range of pH (5-11), and in real water samples including tap water, river water and lake water.	Nitrates	153-157	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	0-4
35525348-3	2022	Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process.	Nitrates	32-39	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
35525348-3	2022	Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	71-74
35525348-3	2022	Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	89-92
35525348-3	2022	Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	116-119
35525348-3	2022	Although some studies have used nitrate isotopic composition (delta15N-NO3- and delta18O-NO3-) to identify nitrate (NO3--N) in urban storm runoff, the relatively low frequency of collecting samples in surface runoff within a single functional area hinders the understanding of spatial variations and dynamic process of NO3--N sources over the runoff process.	Nitrates	107-114	NBL1, DAN family BMP antagonist	Homo sapiens	319-322
35271927-5	2022	We quantified the effects of colder, surface water temperature on the nitrate (NO3-) reduction rate in vegetated marsh and open water bay sediments.	Nitrates	70-77	NBL1, DAN family BMP antagonist	Homo sapiens	79-82
35472839-0	2022	APCS-MLR model: A convenient and fast method for quantitative identification of nitrate pollution sources in groundwater.	Nitrates	80-87	amyloid P component, serum	Homo sapiens	0-4
35202681-4	2022	Five years (2015-2020) of water quantity and quality data from 11 agricultural watersheds in southern Ontario were used to develop GAMs to predict total phosphorus (TP) and nitrate (NO3-) loads.	Nitrates	173-180	NBL1, DAN family BMP antagonist	Homo sapiens	182-185
35568027-4	2022	Surprisingly, avirulent S. Typhimurium was shown to be unable to utilize epithelial-derived nitrate because its chemotaxis receptors McpB and McpC exclude the pathogen from the niche occupied by E. coli.	Nitrates	92-99	hlyB-like ABC transporter-like protein	Escherichia coli	133-137
35019185-3	2022	Simulated fluxes include microbial immobilization and plant uptake, which compete with nitrification and denitrification, respectively, for available soil ammonium (NH4 + ) and nitrate (NO3 - ).	Nitrates	177-184	NBL1, DAN family BMP antagonist	Homo sapiens	186-189
35157864-5	2022	Transcriptome analysis of mouse lungs exposed to nitrate/sulfate aerosols reveals interferon gamma-associated immune response.	Nitrates	49-56	interferon gamma	Mus musculus	82-98
35227848-1	2022	Nitrate (NO3-) pollution in water bodies has received widespread attention, but studies on nitrogen transformation and pollution risk assessment are still limited, especially in rare earth mining areas.	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	9-12
35243632-0	2022	NLP1 binds the CEP1 signalling peptide promoter to repress its expression in response to nitrate.	Nitrates	89-96	nucleoporin 42	Homo sapiens	0-4
35243632-0	2022	NLP1 binds the CEP1 signalling peptide promoter to repress its expression in response to nitrate.	Nitrates	89-96	centriolin	Homo sapiens	15-19
35398714-5	2022	Consumption of nitrate partially preserved glucose tolerance and, within skeletal muscle, normalized insulin-induced Akt phosphorylation, mitochondrial ADP sensitivity, mtH2O2, protein carbonylation and global mitochondrial acetylation status.	Nitrates	15-22	thymoma viral proto-oncogene 1	Mus musculus	117-120
35150690-5	2022	The plotting of delta15N-NO3- versus NO3-/Cl- ratios also supported the assumption that sewage is the dominant nitrate source.	Nitrates	111-118	NBL1, DAN family BMP antagonist	Homo sapiens	37-40
35398714-6	2022	Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate.	Nitrates	0-7	sirtuin 1	Mus musculus	53-58
35398714-6	2022	Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate.	Nitrates	111-118	sirtuin 1	Mus musculus	53-58
35398714-6	2022	Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate.	Nitrates	111-118	sirtuin 1	Mus musculus	207-212
35398714-6	2022	Nitrate also prevented the HFD-mediated reduction in SIRT1 protein, and interestingly, the positive effects of nitrate ingestion on glucose homeostasis and mitochondrial acetylation levels were abolished in SIRT1 inducible knock-out mice, suggesting SIRT1 is required for the beneficial effects of dietary nitrate.	Nitrates	111-118	sirtuin 1	Mus musculus	250-255
35398714-7	2022	Altogether, dietary nitrate preserves mitochondrial ADP sensitivity and global lysine acetylation in HFD-fed mice, while in the absence of SIRT1, the effects of nitrate on glucose tolerance and mitochondrial acetylation were abrogated.	Nitrates	161-168	sirtuin 1	Mus musculus	139-144
35604567-3	2022	Moreover, there is no consensus on the safe administration of dietary nitrate as an ergogenic aid.	Nitrates	70-77	activation induced cytidine deaminase	Homo sapiens	94-97
35421667-1	2022	If we can use toxic aromatic compounds as supplementary carbon source, the simultaneous removal of nitrate (NO3-) and aromatic compounds may be achieved at much lower chemical costs.	Nitrates	99-106	NBL1, DAN family BMP antagonist	Homo sapiens	108-111
35614500-1	2022	In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out.	Nitrates	150-157	transmembrane protein 37	Homo sapiens	109-116
35614500-1	2022	In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out.	Nitrates	150-157	transmembrane protein 37	Homo sapiens	121-124
35614500-1	2022	In this research, the possibility of using hydrogenated Dowex 50WX8 resin for the recovery and separation of Pr(III), Dy(III) and Y(III) from aqueous nitrate solutions were carried out.	Nitrates	150-157	transmembrane protein 37	Homo sapiens	132-135
35604567-17	2022	The effects of dietary nitrate appear to be diminished in individuals with a higher aerobic fitness (peak oxygen consumption (VO2peak) > 60 ml/kg/min), and therefore, aerobic fitness should be taken into account when considering use of dietary nitrate as an ergogenic aid.	Nitrates	23-30	activation induced cytidine deaminase	Homo sapiens	268-271
35573269-6	2022	In particular, in the CS range from 0.02 to 0.03 s-1, the nitrate fraction was 17% on NPF event days and 26% on non-NPF event days.	Nitrates	58-65	citrate synthase	Homo sapiens	22-24
35583665-2	2022	The global increases in the surface and groundwater nitrate (NO3 - ) concentrations due to synthetic fertilizer input have emerged as major sustainability threats to terrestrial and aquatic ecosystems.	Nitrates	52-59	NBL1, DAN family BMP antagonist	Homo sapiens	61-64
35579458-7	2022	Compared to oxic (>60 muM O2) Tara Ocean and high-hypoxic (>20 to <=60 muM O2) BoB samples, we found more SAR11-nar sequences (responsible for reducing nitrate to nitrite) in low-hypoxic (>5 to <=20 muM O2) BoB waters.	Nitrates	152-159	G protein-coupled receptor 15	Homo sapiens	79-82
35579458-7	2022	Compared to oxic (>60 muM O2) Tara Ocean and high-hypoxic (>20 to <=60 muM O2) BoB samples, we found more SAR11-nar sequences (responsible for reducing nitrate to nitrite) in low-hypoxic (>5 to <=20 muM O2) BoB waters.	Nitrates	152-159	G protein-coupled receptor 15	Homo sapiens	207-210
35579458-9	2022	It seems that the nitrite-N was not further reduced to nitrogen through denitrification but likely oxidized to nitrate by Nitrospinae in the BoB OMZ and then accumulated in the form of nitrate-N.	Nitrates	111-118	G protein-coupled receptor 15	Homo sapiens	141-144
35579458-11	2022	Together, these results suggested that reduction of oxygen concentration and OMZ expansion may increase the use of nitrate by SAR11 and N2 production in the BoB.	Nitrates	115-122	G protein-coupled receptor 15	Homo sapiens	157-160
35149011-3	2022	The existence of nitrate in general decreased TCE dechlorination efficiency to varying degrees, and the higher nitrate concentration, the stronger the inhibitory effects, verified by the gradually decreased transcription levels of tceA.	Nitrates	17-24	transcription elongation factor A1	Homo sapiens	231-235
35233916-3	2022	Herein, a modification of nitrate ion (NO3 - ) is proposed and validated to improve the homogeneity of the SEI in practical LMBs.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	39-42
35351554-5	2022	Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3.	Nitrates	46-53	phenylalanine hydroxylase	Homo sapiens	250-252
35351554-5	2022	Besides, the potential selecting advantage of nitrate reducing bacteria over nitrite reducing bacteria and the enrichment of dissimilatory nitrate reduction to ammonium (DNRA) bacteria could be responsible for the nitrite and ammonia accumulation at pH 3.	Nitrates	139-146	phenylalanine hydroxylase	Homo sapiens	250-252
35149011-3	2022	The existence of nitrate in general decreased TCE dechlorination efficiency to varying degrees, and the higher nitrate concentration, the stronger the inhibitory effects, verified by the gradually decreased transcription levels of tceA.	Nitrates	111-118	transcription elongation factor A1	Homo sapiens	231-235
35192730-9	2022	The biopterin, BH4, and norepinephrine contents were increased in penile homogenates from BH4-supplemented Spr-/- mice, and the TH protein levels tended to increase, and their nitrite plus nitrate levels were significantly lower than those of vehicle-treated Spr-/- mice and were approximately the same as vehicle- and BH4-supplemented Spr+/+ mice.	Nitrates	189-196	sepiapterin reductase	Mus musculus	107-110
35065174-0	2022	Enhanced bioremediation of RDX and Co-Contaminants perchlorate and nitrate using an anaerobic dehalogenating consortium in a fractured rock aquifer.	Nitrates	67-74	radixin	Homo sapiens	27-30
35065174-2	2022	Bioremediation of RDX is feasible through biostimulation of native microbes with an organic carbon donor but may be less efficient, or not occur at all, in the presence of the common co-contaminants perchlorate and nitrate.	Nitrates	215-222	radixin	Homo sapiens	18-21
35065174-7	2022	In microcosms with groundwater containing perchlorate and nitrate, RDX degradation began without delay when bioaugmented with 10% WBC-2.	Nitrates	58-65	radixin	Homo sapiens	67-70
35240317-1	2022	Exercise tolerance appears to benefit most from dietary nitrate (NO3-) supplementation when muscle oxygen (O2) availability is low.	Nitrates	56-63	NBL1, DAN family BMP antagonist	Homo sapiens	65-68
35417808-7	2022	Furthermore, the NO3-/Cl- versus Cl- diagram and principal component analysis (PCA) indicated nitrate pollution in groundwater that is subjected to anthropogenic activities such as domestic sewage, agricultural and industrial practices, which lead to degradation of groundwater quality in the area.	Nitrates	94-101	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
35240317-6	2022	Nitrate supplementation increased plasma NO3- (16.2-fold) and NO2- (4.2-fold) and time to volitional fatigue (61.8 +- 56.5 s longer duration vs. placebo visit; p = 0.03).	Nitrates	0-7	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
35038503-3	2022	A higher PM1 mass concentration (63.0 mug m-3) was observed in an industrially influenced district (XG) with major contributions (70.4%) from three secondary inorganic species (sulfate, nitrate, and ammonium) and two oxygenated organic aerosol (OOA) components with different oxygenation levels.	Nitrates	186-193	transmembrane protein 11	Homo sapiens	9-12
35038503-6	2022	The chemical formation mechanisms of secondary PM1 species in the two different districts during the daytime and nighttime are further examined, which indicated the important photochemical formations of nitrate in CG but sulfate in XG during the daytime, whereas favorable aqueous-phase formations of nitrate and LO-OOA in both districts during the nighttime.	Nitrates	203-210	transmembrane protein 11	Homo sapiens	47-50
35038503-6	2022	The chemical formation mechanisms of secondary PM1 species in the two different districts during the daytime and nighttime are further examined, which indicated the important photochemical formations of nitrate in CG but sulfate in XG during the daytime, whereas favorable aqueous-phase formations of nitrate and LO-OOA in both districts during the nighttime.	Nitrates	301-308	transmembrane protein 11	Homo sapiens	47-50
35041959-5	2022	Ship emitted single particles contain organic carbon (OC), elemental carbon (EC), metals, sulfate and nitrate.	Nitrates	102-109	inositol polyphosphate-5-phosphatase D	Homo sapiens	0-4
35146519-2	2022	In Lotus japonicus, two NODULE INCEPTION (NIN)-LIKE PROTEIN (NLP) transcription factors, LjNLP4 and LjNLP1, play pivotal roles in the negative regulation of nodulation by controlling the expression of symbiotic genes in high nitrate conditions.	Nitrates	225-232	NLP1	Lotus japonicus	100-106
35217293-0	2022	Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway.	Nitrates	10-17	thymoma viral proto-oncogene 1	Mus musculus	147-150
35217293-0	2022	Inorganic nitrate and nitrite ameliorate kidney fibrosis by restoring lipid metabolism via dual regulation of AMP-activated protein kinase and the AKT-PGC1alpha pathway.	Nitrates	10-17	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	151-160
35217293-11	2022	Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function.	Nitrates	30-37	thymoma viral proto-oncogene 1	Mus musculus	128-131
35217293-11	2022	Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function.	Nitrates	30-37	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	141-209
35217293-11	2022	Mechanistically, boosting the nitrate-nitrite-NO pathway promoted AMP-activated protein kinase (AMPK) phosphorylation, improved AKT-mediated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1alpha) activity and restored mitochondrial function.	Nitrates	30-37	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	211-220
35254167-6	2022	The microbial consortia in B. glabrata helped in the digestion of complex polysaccharide such as starch, hemicellulose, and chitin for energy supply, and protected the snail from food poisoning and nitrate toxicity.	Nitrates	198-205	snail family transcriptional repressor 1	Homo sapiens	168-173
35146519-6	2022	LjNLP1 is necessary and sufficient to induce LjNRT2.1 expression, thereby regulating nitrate uptake/transport.	Nitrates	85-92	NLP1	Lotus japonicus	0-6
35146519-8	2022	We further show that LjNIN, a positive regulator of nodulation, counteracts the LjNLP1-dependent induction of LjNRT2.1 expression, which is linked to a reduction in nitrate uptake.	Nitrates	165-172	nin	Lotus japonicus	21-26
35146519-8	2022	We further show that LjNIN, a positive regulator of nodulation, counteracts the LjNLP1-dependent induction of LjNRT2.1 expression, which is linked to a reduction in nitrate uptake.	Nitrates	165-172	NLP1	Lotus japonicus	80-86
35394760-2	2022	In this work, FeOOH nanorod with intrinsic oxygen vacancy supported on carbon paper (FeOOH/CP) is proposed as a high-performance electrocatalyst for converting nitrate to ammonia at room temperature.	Nitrates	160-167	ceruloplasmin	Homo sapiens	91-93
35357149-0	2022	Arc-Induced Nitrate Reagent Ion for Analysis of Trace Explosives on Surfaces Using Atmospheric Pressure Arc Desorption/Ionization Mass Spectrometry.	Nitrates	12-19	activity regulated cytoskeleton associated protein	Homo sapiens	0-3
35436155-2	2022	OBJECTIVE: To measure temporal trends in the coprescription of nitrates and PDE5 inhibitors and to measure the association between cardiovascular outcomes and the coprescription of nitrates with PDE5 inhibitors.	Nitrates	181-189	phosphodiesterase 5A	Homo sapiens	195-199
35436155-9	2022	During this period, the prescription rate for PDE5 inhibitors in patients with IHD who were taking nitrates increased from an average of 0.9 prescriptions (95% CI, 0.5 to 1.2 prescriptions) per 100 persons per year in 2000 to 19.5 prescriptions (CI, 18.0 to 21.1 prescriptions) in 2018.	Nitrates	99-107	phosphodiesterase 5A	Homo sapiens	46-50
35436155-12	2022	CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates.	Nitrates	123-131	phosphodiesterase 5A	Homo sapiens	42-46
35357149-0	2022	Arc-Induced Nitrate Reagent Ion for Analysis of Trace Explosives on Surfaces Using Atmospheric Pressure Arc Desorption/Ionization Mass Spectrometry.	Nitrates	12-19	activity regulated cytoskeleton associated protein	Homo sapiens	104-107
35357149-2	2022	In APADI, neutral explosives readily bind to the gas-phase nitrate ion, NO3-, induced by arc discharge to form anionic adducts (M+NO3)-.	Nitrates	59-66	activity regulated cytoskeleton associated protein	Homo sapiens	89-92
35229477-1	2022	Ammonium (NH4 + ) and nitrate (NO3 - ) are major inorganic nitrogen (N) source for plants.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	31-34
35392923-8	2022	The functionality of the NOS2-2 protein was analyzed by transient transfection of expression clones in human DLD1 cells and nitrate measurement in the supernatant of these cells.	Nitrates	124-131	nitric oxide synthase 2	Homo sapiens	25-31
35299236-1	2022	Electrocatalytic nitrate (NO3-) reduction not only generates high-value ammonia (NH3) but holds significant potential in the control of NO3- contaminants in natural environments.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	26-29
35299236-1	2022	Electrocatalytic nitrate (NO3-) reduction not only generates high-value ammonia (NH3) but holds significant potential in the control of NO3- contaminants in natural environments.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	136-139
35459501-7	2022	The formation of nitrate at night mainly originated from N2O5 uptake, and the maximum production rate of NO3- reached 6.5 ppbv/hr.	Nitrates	17-24	NBL1, DAN family BMP antagonist	Homo sapiens	105-108
35229477-3	2022	NO3 - usually causes no toxicity and can mitigate ammonium toxicity even at low concentrations, referring to as nitrate-dependent alleviation of ammonium toxicity.	Nitrates	112-119	NBL1, DAN family BMP antagonist	Homo sapiens	0-3
35459501-9	2022	The predominant roles of NO3 and N2O5 in nitrate formation and NOx removal in the YRD region was highlighted in this study.	Nitrates	41-48	NBL1, DAN family BMP antagonist	Homo sapiens	25-28
35229477-11	2022	Our study thus revealed NRT1.1 and SLAH3 form a functional unit to regulate nitrate-dependent alleviation of ammonium toxicity through regulating NO3 - transport and balancing rhizosphere acidification.	Nitrates	76-83	NBL1, DAN family BMP antagonist	Homo sapiens	146-149
35357062-5	2022	We demonstrated distinct salt stress resistance between Ler and Col-0 depending on the differences in nitrate level, which was explained by different regulation of the NIA2 gene expression in these two ecotypes.	Nitrates	102-109	nitrate reductase 2	Arabidopsis thaliana	168-172
35365707-1	2022	Changes in the aerosol composition of sulfate (SO42-) and nitrate (NO3-) from 2012 to 2019 have been captured as a paradigm shift in the region downwind of China.	Nitrates	58-65	NBL1, DAN family BMP antagonist	Homo sapiens	67-70
35355184-0	2022	Identification of sources and transformations of nitrate in Cr(VI)-impacted alluvial aquifers by a hydrogeochemical and delta15N-NO3- and delta18O-NO3 - isotopes approach.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	129-132
35355184-0	2022	Identification of sources and transformations of nitrate in Cr(VI)-impacted alluvial aquifers by a hydrogeochemical and delta15N-NO3- and delta18O-NO3 - isotopes approach.	Nitrates	49-56	NBL1, DAN family BMP antagonist	Homo sapiens	147-150
35348891-1	2022	MAIN CONCLUSION: The local and long-distance signaling pathways mediated by the leucine-rich repeat receptor kinase HAR1 suppress root branching and promote primary root length in response to nitrate supply.	Nitrates	192-199	CM0216.560.nc	Lotus japonicus	116-120
35352014-1	2022	BACKGROUND/OBJECTIVES: To compare the effects of supplemental inorganic nitrate (NO3) on microvascular endothelial function and blood pressure in younger vs. older participants.	Nitrates	72-79	NBL1, DAN family BMP antagonist	Homo sapiens	81-84
35348891-7	2022	We show that the har1 mutant exhibits high nitrate sensitivity during root development.	Nitrates	43-50	CM0216.560.nc	Lotus japonicus	17-21
35348891-8	2022	The uninfected har1 mutant significantly increased lateral root number and reduced primary root length in the presence of 3 mM nitrate, compared with the wild-type and tml mutant.	Nitrates	127-134	CM0216.560.nc	Lotus japonicus	15-19
35348891-9	2022	Grafting experiments indicated that local and long-distance signaling pathways via root- and shoot-acting HAR1 additively regulated root morphology under the moderate nitrate concentrations.	Nitrates	167-174	CM0216.560.nc	Lotus japonicus	106-110
35348891-10	2022	These findings allow us to propose that HAR1-mediated signaling pathways control the root system architecture by suppressing lateral root branching and promoting primary root elongation in response to nitrate availability.	Nitrates	201-208	CM0216.560.nc	Lotus japonicus	40-44
35293417-3	2022	Inorganic nitrate is a ubiquitous component of atmospheric aqueous phases such as cloudwater, fog, and aqueous aerosols.	Nitrates	10-17	zinc finger protein, FOG family member 1	Homo sapiens	94-97
35364374-5	2022	However, the application of Se at 4 and 16 mumol L-1, prompted a relief of this stress, reducing both lipid peroxidation and the sugar content, and increasing the nitrate concentration.	Nitrates	163-170	squalene epoxidase	Homo sapiens	28-30
35364374-6	2022	In addition, in the case of the highest concentration of Se (16 mumol L-1), the values of nitrate were comparable those control plants.	Nitrates	90-97	squalene epoxidase	Homo sapiens	57-59
34978758-1	2022	The electrocatalytic nitrate-to-ammonia reduction reaction route (NARR) is one of the emerging routes toward the green ammonia synthesis, and its conversion efficiency is controlled mainly by the hydrogenation selectivity.	Nitrates	21-28	ras-related protein Rab-34	Homo sapiens	66-70
35360239-2	2022	This study investigates if performance at simulated altitude is improved to a larger extent when high-intensity interval training is performed in normobaric hypoxia and if this is potentiated when combined with chronic dietary nitrate (NO3 -) supplementation.	Nitrates	227-234	NBL1, DAN family BMP antagonist	Homo sapiens	236-239
35424754-4	2022	To have a better understanding of the structure-property relationships of furazan-bicyclic scaffolds and nitrate groups, their thermal behaviors, detonation performances and the sensitivities were investigated via differential scanning calorimetry (DSC), ESP analysis, Hirshfeld surfaces calculation, EXPLO5 program and BAM standard techniques.	Nitrates	105-112	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	255-258
35263337-8	2022	Using RNA sequencing analysis and in vitro biochemical experiment, we found NAC056 regulated the expression of genes required for NO3- assimilation, directly targeting the key nitrate assimilation gene NIA1.	Nitrates	176-183	nitrate reductase 1	Arabidopsis thaliana	202-206
35263337-9	2022	In addition, mutation of NIA1 suppresses LR development and nitrate deficiency tolerance in the 35S::NAC056 transgenic plants.	Nitrates	60-67	nitrate reductase 1	Arabidopsis thaliana	25-29
35150744-5	2022	In each of these two cases, the maximum amount of nitrite or nitrate formed was at best stoichiometric with the concentration of Mka HLP.	Nitrates	61-68	HLP	Homo sapiens	133-136
35235063-2	2022	The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	38-41
35235063-2	2022	The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	198-201
35235063-2	2022	The sources and transport of nitrate (NO3-) in urban stormwater runoff were investigated by analysing different forms of N, water isotopes (deltaD-H2O and delta18O-H2O), and NO3- isotopes (delta15N-NO3- and delta18O-NO3-) in urban stormwater runoff in a residential area in Hangzhou, China.	Nitrates	29-36	NBL1, DAN family BMP antagonist	Homo sapiens	216-219
35241877-6	2022	Nitrate losses at landscape scale increased during the 2019-2020 extreme wet-weather period to 2.04-4.54 kg ha-1.	Nitrates	0-7	Rho GTPase activating protein 45	Homo sapiens	108-112
35007932-0	2022	Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway.	Nitrates	9-16	serine/threonine kinase 11	Homo sapiens	117-121
34998066-7	2022	Within 2 h of electrolysis, Cu/MWVNT/FTO exhibits more than 65% removal of nitrate at -1.80 V (vs. SCE).	Nitrates	75-82	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	37-40
34998066-13	2022	Compared to earlier systems, the Cu/MWCNT/FTO is environmentally stable, safe, non-costly with high nitrate removal efficiency and selectivity.	Nitrates	100-107	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	42-45
35007932-0	2022	Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway.	Nitrates	9-16	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	122-126
34787344-1	2022	RATIONALE: Analyses of the isotope ratios of nitrogen (15 N/14 N) and oxygen (18 O/16 O) in nitrate (NO3 - ) with the denitrifier method require relatively high sample volumes at low concentrations (<= 1 muM) to afford sufficient analyte for mass spectrometry, resulting in isotopic offsets compared to more concentrated samples of the same isotopic composition.	Nitrates	92-99	NBL1, DAN family BMP antagonist	Homo sapiens	101-104
35128037-8	2022	The wastewater analyses confirm the occurrence of nitrate (NO3 -), nitrite (NO2 -), and ammonia (NH4 +), which provide an appropriate condition for NO2 release.	Nitrates	50-57	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
35391922-2	2022	At least two major pathways produce NO: (1) the L-arginine-NO-oxidative pathway in which NO synthase (NOS) enzymes convert L-arginine to NO; (2) the nitrate-nitrite-NO reductive pathway in which NO is produced from the serial reduction of nitrate and nitrite.	Nitrates	239-246	nitric oxide synthase 2	Homo sapiens	89-100
35101982-2	2022	The electrochemical nitrate reduction reaction (NO3 -RR) is a promising approach for nitrate removal and NH3 production at ambient conditions, but efficient electrocatalysts are lacking.	Nitrates	20-27	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
35101982-2	2022	The electrochemical nitrate reduction reaction (NO3 -RR) is a promising approach for nitrate removal and NH3 production at ambient conditions, but efficient electrocatalysts are lacking.	Nitrates	85-92	NBL1, DAN family BMP antagonist	Homo sapiens	48-51
35161943-2	2022	The first nitrate transporter activity biosensor NiTrac1 converted the dual-affinity nitrate transceptor NPF6.3 into fluorescence activity sensors.	Nitrates	10-17	nitrate transporter 1.1	Arabidopsis thaliana	105-111
35161943-2	2022	The first nitrate transporter activity biosensor NiTrac1 converted the dual-affinity nitrate transceptor NPF6.3 into fluorescence activity sensors.	Nitrates	85-92	nitrate transporter 1.1	Arabidopsis thaliana	105-111
35067307-0	2022	Overexpression of tomato thioredoxin h (SlTrxh) enhances excess nitrate stress tolerance in transgenic tobacco interacting with SlPrx protein.	Nitrates	64-71	thioredoxin-like protein CITRX, chloroplastic	Solanum lycopersicum	25-36
35046022-0	2022	Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate.	Nitrates	87-94	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	35-39
34545936-3	2022	In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression.	Nitrates	86-93	transcription regulatory protein SNF2	Arabidopsis thaliana	56-59
34545936-3	2022	In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression.	Nitrates	86-93	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	75-78
34545936-3	2022	In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression.	Nitrates	86-93	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	105-130
34545936-3	2022	In addition, genetic and molecular analysis showed that BRM interacts with GNC (GATA, NITRATE-INDUCIBLE, CARBONMETABOLISM INVOLVED), a GATA transcription factor that represses flowering by directly repressing SOC1 expression.	Nitrates	86-93	GATA type zinc finger transcription factor family protein	Arabidopsis thaliana	135-139
35046022-0	2022	Spatiotemporal analysis identifies ABF2 and ABF3 as key hubs of endodermal response to nitrate.	Nitrates	87-94	abscisic acid responsive elements-binding factor 3	Arabidopsis thaliana	44-48
35046022-8	2022	Validated targets of ABF2 and ABF3 account for more than 50% of the nitrate-responsive transcriptome in the endodermis.	Nitrates	68-75	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	21-25
35046022-8	2022	Validated targets of ABF2 and ABF3 account for more than 50% of the nitrate-responsive transcriptome in the endodermis.	Nitrates	68-75	abscisic acid responsive elements-binding factor 3	Arabidopsis thaliana	30-34
35046022-9	2022	Moreover, ABF2 and ABF3 are involved in nitrate-induced lateral root growth.	Nitrates	40-47	abscisic acid responsive elements-binding factor 2	Arabidopsis thaliana	10-14
35046022-9	2022	Moreover, ABF2 and ABF3 are involved in nitrate-induced lateral root growth.	Nitrates	40-47	abscisic acid responsive elements-binding factor 3	Arabidopsis thaliana	19-23
35140727-4	2021	Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism.	Nitrates	128-135	NIN like protein 7	Arabidopsis thaliana	24-61
35140727-8	2021	Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity.	Nitrates	64-71	NIN like protein 7	Arabidopsis thaliana	6-10
35140727-4	2021	Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism.	Nitrates	128-135	NIN like protein 7	Arabidopsis thaliana	63-67
35140727-8	2021	Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity.	Nitrates	64-71	nitrate reductase 1	Arabidopsis thaliana	31-48
35140727-8	2021	Since nlp7 also expressed less nitrate reductase (NR) activity, nitrate accumulated to abnormally high levels with or without salinity.	Nitrates	64-71	nitrate reductase 1	Arabidopsis thaliana	50-52
35140727-4	2021	Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism.	Nitrates	181-188	NIN like protein 7	Arabidopsis thaliana	24-61
35140727-9	2021	We attributed the enhanced salt tolerance of nlp7 to the balanced accumulation of nitrate anions and sodium cations.	Nitrates	82-89	NIN like protein 7	Arabidopsis thaliana	45-49
35140727-4	2021	Our characterization of NODULE INCEPTION (NIN)-like PROTEIN 7 (NLP7), a transcription factor regulating the primary response to nitrate, revealed an intersection of salt stress and nitrate metabolism.	Nitrates	181-188	NIN like protein 7	Arabidopsis thaliana	63-67
35163124-1	2022	The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite.	Nitrates	113-120	nitrate reductase 1	Arabidopsis thaliana	26-30
35163124-1	2022	The two homologous genes, NIA1 and NIA2, encode nitrate reductases in Arabidopsis, which govern the reduction of nitrate to nitrite.	Nitrates	113-120	nitrate reductase 2	Arabidopsis thaliana	35-39
35045112-11	2022	Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition.	Nitrates	83-90	glucan endo-1,3-beta-glucosidase, basic isoform	Malus domestica	8-13
35045112-11	2022	Both SS+Glu-2 and Glu-2 treatments significantly enhanced (P<0.05) the contents of nitrate (NO3-N) and nitrite (NO2-N), but sharply decreased (P<0.05) the ammonium (NH4+-N) content compared with no glucose addition.	Nitrates	83-90	glucan endo-1,3-beta-glucosidase, basic isoform	Malus domestica	18-23
35052670-4	2022	The organic nitrates studied showed different vasodilation and tolerance profiles, probably due to the ability or inability of the compounds to interact with the aldehyde dehydrogenase-2 enzyme (ALDH-2) involved in bioactivation.	Nitrates	12-20	aldehyde dehydrogenase 2 family member	Homo sapiens	162-186
35046428-10	2022	These findings offer new perspectives on the mechanisms by which the chrysanthemum CBL interacting protein kinase CmCIPK23 influences nitrate signaling.	Nitrates	134-141	cystathionine beta-lyase	Arabidopsis thaliana	83-86
35052670-4	2022	The organic nitrates studied showed different vasodilation and tolerance profiles, probably due to the ability or inability of the compounds to interact with the aldehyde dehydrogenase-2 enzyme (ALDH-2) involved in bioactivation.	Nitrates	12-20	aldehyde dehydrogenase 2 family member	Homo sapiens	195-201
35052670-6	2022	The results of this study could be further evidence of the involvement of ALDH-2 in the development of nitrate tolerance.	Nitrates	103-110	aldehyde dehydrogenase 2 family member	Homo sapiens	74-80
35052670-7	2022	Moreover, the behavior of organic nitrates with antioxidant properties supports the hypothesis of the involvement of ROS in inactivating ALDH-2.	Nitrates	34-42	aldehyde dehydrogenase 2 family member	Homo sapiens	137-143
35095967-16	2021	Overall, these results demonstrated that increasing the NH4 +/NO3 - ratio at the seedling stage induced the accumulation of reactive oxygen species, which in turn enhanced root glutathione metabolism and lignification, thereby resulting in increased root oxidative tolerance at the cost of reducing nitrate transport and utilization, which reduced leaf photosynthetic capacity and, ultimately, plant biomass accumulation.	Nitrates	299-306	NBL1, DAN family BMP antagonist	Homo sapiens	62-65
35047570-6	2021	Correlation analysis showed MEG3 expression highly correlated with ET1 and Nitrate concentration.	Nitrates	75-82	maternally expressed 3	Homo sapiens	28-32
35095982-4	2021	Ion-selective electrodes (ISEs) support the possibility of NO 3 -  -N measurement by measuring the nitrate ( NO 3 -  ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 -  ions.	Nitrates	99-106	NBL1, DAN family BMP antagonist	Homo sapiens	59-63
35095982-4	2021	Ion-selective electrodes (ISEs) support the possibility of NO 3 -  -N measurement by measuring the nitrate ( NO 3 -  ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 -  ions.	Nitrates	99-106	NBL1, DAN family BMP antagonist	Homo sapiens	109-113
35095982-4	2021	Ion-selective electrodes (ISEs) support the possibility of NO 3 -  -N measurement by measuring the nitrate ( NO 3 -  ) ions in soil quickly and accurately due to the high water solubility and mobility of NO 3 -  ions.	Nitrates	99-106	NBL1, DAN family BMP antagonist	Homo sapiens	204-208
35046980-5	2021	The SSP, CEP1 (C-TERMINALLY ENCODED PEPTIDE) enhanced nitrate uptake rate per unit root length in Medicago truncatula plants deprived of N in the high-affinity transport range.	Nitrates	54-61	Cysteine proteinases superfamily protein	Arabidopsis thaliana	9-13
35046980-6	2021	Single structural variants of M. truncatula and Arabidopsis thaliana specific CEP1 peptides, MtCEP1D1:hyp4,11 and AtCEP1:hyp4,11, enhanced uptake not only of nitrate, but also phosphate and sulfate in both model plant species.	Nitrates	158-165	Cysteine proteinases superfamily protein	Arabidopsis thaliana	78-82
35046980-6	2021	Single structural variants of M. truncatula and Arabidopsis thaliana specific CEP1 peptides, MtCEP1D1:hyp4,11 and AtCEP1:hyp4,11, enhanced uptake not only of nitrate, but also phosphate and sulfate in both model plant species.	Nitrates	158-165	Cysteine proteinases superfamily protein	Arabidopsis thaliana	114-120
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	0-7	alternative oxidase 1A	Arabidopsis thaliana	44-49
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	0-7	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	50-54
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	120-127	alternative oxidase 1A	Arabidopsis thaliana	44-49
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	120-127	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	50-54
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	140-147	alternative oxidase 1A	Arabidopsis thaliana	44-49
34974624-7	2022	Nitrate acquisition rate was accelerated in aox1a/ucp1, but its transport activity was decreased, which resulted in low nitrate content and nitrate reductase activity under low N condition.	Nitrates	140-147	plant uncoupling mitochondrial protein 1	Arabidopsis thaliana	50-54
2517590-4	1989	In addition, while the expression of c-myc, following partial hepatectomy returned to basal level by 4 h, the induced expression of c-myc persisted for up to 40 h during the lead nitrate-induced liver cell proliferation.	Nitrates	179-186	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	37-42
2557415-9	1989	Thus, it is apparently the nitrate moiety of the chemical structure by which nicorandil actively and strongly reduces [Ca++]i in vascular smooth muscle cells.	Nitrates	27-34	carbonic anhydrase 1	Rattus norvegicus	119-125
16667152-6	1989	Incorporation of [(35)S]methionine during nitrate treatment revealed that total soluble protein and nitrate reductase protein synthesis were both depressed by the O(2) environment relative to air, but both recovered when leaves were shifted from O(2) to air.	Nitrates	42-49	nitrate reductase [NADH] 1	Zea mays	100-117
2099413-0	1990	Inhibition of platelet activation by the nitrate Sin-1: studies with human aequorin-loaded platelets.	Nitrates	41-48	MAPK associated protein 1	Homo sapiens	49-54
2517590-4	1989	In addition, while the expression of c-myc, following partial hepatectomy returned to basal level by 4 h, the induced expression of c-myc persisted for up to 40 h during the lead nitrate-induced liver cell proliferation.	Nitrates	179-186	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	132-137
2544557-3	1989	We have previously identified a locus called frdR which pleiotropically affects nitrate repression of fumarate reductase, trimethylamine N-oxide reductase, and alcohol dehydrogenase gene expression and nitrate induction of nitrate reductase expression (L. V. Kalman and R. P. Gunsalus, J. Bacteriol.	Nitrates	80-87	Alcohol dehydrogenase	Escherichia coli	160-181
16666874-0	1989	Transient Accumulation of Nitrite Reductase mRNA in Maize following the Addition of Nitrate.	Nitrates	84-91	ferredoxin--nitrite reductase, chloroplastic	Zea mays	26-43
2790879-12	1989	With regard to the very satisfactory experience with the administration of nitrates in this indication their combined administration with vasopressin or its derivatives is considered.	Nitrates	75-83	arginine vasopressin	Homo sapiens	138-149
16666874-1	1989	Expression of the gene coding for nitrite reductase (NiR) is induced upon the addition of nitrate.	Nitrates	90-97	ferredoxin--nitrite reductase, chloroplastic	Zea mays	34-51
16666874-1	1989	Expression of the gene coding for nitrite reductase (NiR) is induced upon the addition of nitrate.	Nitrates	90-97	ferredoxin--nitrite reductase, chloroplastic	Zea mays	53-56
16666874-3	1989	There is a rapid induction of NiR mRNA upon addition of nitrate, increasing first in the roots and then in the leaves.	Nitrates	56-63	ferredoxin--nitrite reductase, chloroplastic	Zea mays	30-33
16666874-9	1989	The NiR protein level, on the other hand, increases gradually somewhat after the increase in mRNA and remains at high levels at least for 24 hours after the addition of nitrate.	Nitrates	169-176	ferredoxin--nitrite reductase, chloroplastic	Zea mays	4-7
16666879-5	1989	When nitrate was supplied to N-starved, etiolated corn plants, nitrate reductase, and glyceraldehyde-3-phosphate dehydrogenase mRNA levels in leaves increased in parallel.	Nitrates	5-12	nitrate reductase [NADH] 1	Zea mays	63-80
16666879-5	1989	When nitrate was supplied to N-starved, etiolated corn plants, nitrate reductase, and glyceraldehyde-3-phosphate dehydrogenase mRNA levels in leaves increased in parallel.	Nitrates	5-12	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	Zea mays	86-126
16666879-6	1989	When green leaves were treated with nitrate, only nitrate reductase mRNA levels were increased.	Nitrates	36-43	nitrate reductase [NADH] 1	Zea mays	50-67
16666879-7	1989	Nitrate is a specific inducer of nitrate reductase in green leaves, but appears to have a more general effect in etiolated leaves.	Nitrates	0-7	nitrate reductase [NADH] 1	Zea mays	33-50
16666879-8	1989	In the dark, nitrate induced nitrate reductase expression in both etiolated and green leaves, indicating light and functional chloroplast were not required for enzyme expression.	Nitrates	13-20	nitrate reductase [NADH] 1	Zea mays	29-46
16666905-0	1989	Nitrate effects on nitrate reductase activity and nitrite reductase mRNA levels in maize suspension cultures.	Nitrates	0-7	nitrate reductase [NADH] 1	Zea mays	19-36
16666905-3	1989	Both NR and NiR mRNA were transiently induced with levels decreasing after the 2 hours despite the continued presence of nitrate in the medium.	Nitrates	121-128	nitrate reductase [NADH] 1	Zea mays	5-7
16666905-0	1989	Nitrate effects on nitrate reductase activity and nitrite reductase mRNA levels in maize suspension cultures.	Nitrates	0-7	ferredoxin--nitrite reductase, chloroplastic	Zea mays	50-67
16666905-3	1989	Both NR and NiR mRNA were transiently induced with levels decreasing after the 2 hours despite the continued presence of nitrate in the medium.	Nitrates	121-128	ferredoxin--nitrite reductase, chloroplastic	Zea mays	12-15
2501096-5	1989	More recently, a potential molecular explanation for nitrate tolerance has been proposed: sulfhydryl group depletion in smooth muscle cells resulting in reduced formation of S-nitrosothiols on nitrate exposure with resultant reduced activation of cyclic GMP.	Nitrates	53-60	5'-nucleotidase, cytosolic II	Homo sapiens	254-257
2577296-2	1989	The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma.	Nitrates	47-55	alpha hemoglobin stabilizing protein	Homo sapiens	93-130
2577296-2	1989	The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma.	Nitrates	47-55	alpha hemoglobin stabilizing protein	Homo sapiens	132-136
2577296-2	1989	The recently elucidated mechanism of action of nitrates, acting on a common pathway with the endothelium-derived relaxation factor (EDRF), suggests an important role for guanylate cyclase and cyclic GMP in maintaining coronary artery patency in patients with coronary atheroma.	Nitrates	47-55	5'-nucleotidase, cytosolic II	Homo sapiens	199-202
2784476-1	1989	L-arginine-dependent synthesis of nitrite (NO2-) and nitrate (NO3-) by macrophages correlates with and is required for their execution of nonspecific cytotoxicity toward some tumor cells and microbes.	Nitrates	53-60	NBL1, DAN family BMP antagonist	Mus musculus	62-65
2658373-1	1989	Metabolism of organic nitrates results in the formation of inorganic nitrites that can oxidize hemoglobin to methemoglobin.	Nitrates	22-30	hemoglobin subunit gamma 2	Homo sapiens	109-122
2658373-3	1989	Based on the results of these trials, organic nitrate use does appear to increase methemoglobin content but not to a clinically significant extent.	Nitrates	46-53	hemoglobin subunit gamma 2	Homo sapiens	82-95
2722365-1	1989	Increasing levels of nitrate (NO3-) in drinking water in Denmark is of concern due to the possibility of an associated increase in long-term exposure to endogeneously formed N-nitroso compounds.	Nitrates	21-28	NBL1, DAN family BMP antagonist	Homo sapiens	30-33
2722365-3	1989	People drinking nitrate-free water have an intake of 37 mg NO3- per day.	Nitrates	16-23	NBL1, DAN family BMP antagonist	Homo sapiens	59-62
2548453-3	1989	The study showed that the nitrate content in berseem grown near the factory had higher NO3 values exceeding 2% NO3 in DM in some cases.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	87-90
2548453-3	1989	The study showed that the nitrate content in berseem grown near the factory had higher NO3 values exceeding 2% NO3 in DM in some cases.	Nitrates	26-33	NBL1, DAN family BMP antagonist	Homo sapiens	111-114
16347879-3	1989	Nitrate affinity (K(m)) for mixed populations of denitrifying bacteria in unfertilized agricultural soils and pond sediments ranged from 1.8 to 13.7 muM.	Nitrates	0-7	latexin	Homo sapiens	149-152
2573982-4	1989	CONCLUSION: A desensitization of soluble guanylate cyclase to activation with NO can be demonstrated under non-physiological conditions (disrupted cells) in homogenates from nitrate tolerant RA.	Nitrates	174-181	guanylate cyclase	Bos taurus	41-58
2733245-3	1989	Plasma SOD activities were measured by the nitrate method.	Nitrates	43-50	superoxide dismutase 1	Homo sapiens	7-10
2468964-2	1989	The present study was performed to elucidate if large oral doses of N-acetylcysteine (NAC, 2,400 mg X 2), a donor of sulfhydryl groups, given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG).	Nitrates	194-201	NACC family member 2	Homo sapiens	68-103
2468964-2	1989	The present study was performed to elucidate if large oral doses of N-acetylcysteine (NAC, 2,400 mg X 2), a donor of sulfhydryl groups, given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG).	Nitrates	220-227	NACC family member 2	Homo sapiens	68-103
2568418-4	1989	Some auranofin analogues having chloride or nitrate leaving groups that inhibit DNA polymerase-alpha were found to be potent inhibitors of IL-1 induced resorption.	Nitrates	44-51	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	80-100
2559883-3	1989	Nitrosylhemoglobin shows a characteristic electron spin resonance (ESR) signal due to an odd electron localized on the nitrogen atom of NO and reacts with oxygen to yield nitrate and methemoglobin, which is rapidly reduced by methemoglobin reductase in red cells.	Nitrates	171-178	hemoglobin subunit gamma 2	Homo sapiens	226-239
2511690-7	1989	The real clinical importance of nitrates became, however, evident only in the last decade with the discovery of EDRF, the so-called endothelial-derived relaxing factor, an endogenous compound of endothelial origin at least partly consisting of nitrous oxide and therefore, like nitrates, it exerts its effect through the stimulation of cGMP.	Nitrates	32-40	alpha hemoglobin stabilizing protein	Homo sapiens	112-116
2511690-7	1989	The real clinical importance of nitrates became, however, evident only in the last decade with the discovery of EDRF, the so-called endothelial-derived relaxing factor, an endogenous compound of endothelial origin at least partly consisting of nitrous oxide and therefore, like nitrates, it exerts its effect through the stimulation of cGMP.	Nitrates	278-286	alpha hemoglobin stabilizing protein	Homo sapiens	112-116
16666376-5	1988	Nitrate stimulated a rapid induction of the NiR mRNA in both roots and leaves.	Nitrates	0-7	ferredoxin--nitrite reductase, chloroplastic	Zea mays	44-47
2555979-3	1989	Nitrate (GTN)-induced relaxation was accompanied by a 2- to 3-fold increase of cyclic GMP content in the vessel walls.	Nitrates	0-7	5'-nucleotidase, cytosolic II	Homo sapiens	86-89
2573982-2	1989	Nitrate tolerance significantly attenuated NTG-induced vasodilation of precontracted (1.0 microM norepinephrine) RA, increase in cyclic GMP in RA and SMC, and activation of guanylate cyclase in homogenates as compared to controls.	Nitrates	0-7	guanylate cyclase	Bos taurus	173-190
16666423-0	1988	The role of nitrate and ammonium ions and light on the induction of nitrate reductase in maize leaves.	Nitrates	12-19	nitrate reductase [NADH] 1	Zea mays	68-85
16666409-8	1988	Only the plastidic portion of the glutamine synthetase increased to about 80% in cells grown on ammonium (compared to about 40% in cells grown on nitrate).	Nitrates	146-153	uncharacterized protein	Chlamydomonas reinhardtii	34-54
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	interferon gamma	Mus musculus	12-28
3170537-4	1988	Mutant 2172 is affected in methylammonium but not in ammonium uptake capacity and shows derepressed nitrate and nitrite reductase activities in media containing nitrate plus methylammonium but not in nitrate plus ammonium media.	Nitrates	161-168	uncharacterized protein	Chlamydomonas reinhardtii	112-129
3170537-4	1988	Mutant 2172 is affected in methylammonium but not in ammonium uptake capacity and shows derepressed nitrate and nitrite reductase activities in media containing nitrate plus methylammonium but not in nitrate plus ammonium media.	Nitrates	161-168	uncharacterized protein	Chlamydomonas reinhardtii	112-129
3170537-7	1988	From genetic and kinetic evidences we conclude that in C. reinhardtii two different carriers are responsible for the transport of both ammonium and methylammonium and that methylammonium (ammonium) transport is a reversible process probably inhibited by the intracellular ammonium which, in turn, regulates nitrate and nitrite reductase levels.	Nitrates	307-314	uncharacterized protein	Chlamydomonas reinhardtii	319-336
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	interferon gamma	Rattus norvegicus	30-40
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	tumor necrosis factor	Mus musculus	58-79
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	tumor necrosis factor	Rattus norvegicus	81-85
3142779-2	1988	Recombinant interferon-gamma (rIFN-gamma) and recombinant tumor necrosis factor (rTNF) synergize to induce nitrite (NO2-) and nitrate (NO3-) synthesis from L-arginine as well as to cause inhibition of the iron-dependent enzyme aconitase in macrophages.	Nitrates	126-133	NBL1, DAN family BMP antagonist	Mus musculus	135-138
3154691-12	1988	Therefore nitrates may particularly be effective in vessels with deficient EDRF release.	Nitrates	10-18	alpha hemoglobin stabilizing protein	Homo sapiens	75-79
2851879-5	1988	The marked enrichment of H+, SO4(2-) and NO3- in precipitation compared with NH4+ could be explained by assuming either that SO2 and NO2 are oxidized in cloud droplets or that acidic sulfate and nitrate are scavenged directly in-cloud or below-cloud.	Nitrates	195-202	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	87-92
16347651-0	1988	Sub-Parts-Per-Billion Nitrate Method: Use of an N(2)O-Producing Denitrifier to Convert NO(3) or NO(3) to N(2)O.	Nitrates	22-29	NBL1, DAN family BMP antagonist	Homo sapiens	96-101
16347658-2	1988	The isolate, designated GS-15, grew in defined anaerobic medium with acetate as the sole electron donor and Fe(III), Mn(IV), or nitrate as the sole electron acceptor.	Nitrates	128-135	Bet1 golgi vesicular membrane trafficking protein like	Homo sapiens	24-29
16666313-1	1988	The influence of light-dark cycles and nitrate supply on nitrate reductase (NR) mRNA levels was studied in two plant species, tobacco (Nicotiana tabacum) and tomato (Lycopersicon esculentum) using specific NR DNA probes.	Nitrates	39-46	nitrate reductase [NADH]	Solanum lycopersicum	57-74
16666313-1	1988	The influence of light-dark cycles and nitrate supply on nitrate reductase (NR) mRNA levels was studied in two plant species, tobacco (Nicotiana tabacum) and tomato (Lycopersicon esculentum) using specific NR DNA probes.	Nitrates	39-46	nitrate reductase [NADH]	Solanum lycopersicum	76-78
3393528-0	1988	Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains.	Nitrates	13-20	nitrate reductase 1	Arabidopsis thaliana	74-91
3422089-2	1988	These metabolic changes occur in parallel with L-citrulline, nitrate, and nitrate synthesis from L-arginine by EMT-6 cells.	Nitrates	74-81	IL2 inducible T cell kinase	Mus musculus	111-114
24221417-9	1988	Nitrate reductase was induced in bacteroids of strain CB1809 when they were incubated in-vitro with nitrate or nitrite.	Nitrates	100-107	inducible nitrate reductase [NADH] 1	Glycine max	0-17
3137069-3	1988	Evidence for nitrate induced PGI2 stimulation is presented by inhibition of its formation by indomethacin and dexamethasone, the demonstration of inhibition of thrombin induced thromboxane generation of washed platelet suspensions by nitrate stimulated vessel incubates and an enhanced accumulation of the hydrolysis product of PGI2, 6-oxo-PGF1 alpha, in incubates of teopranitol stimulated vessels.	Nitrates	234-241	coagulation factor II, thrombin	Bos taurus	160-168
2887427-15	1987	The ATPase is insensitive to azide or vanadate but is inhibited by relatively low concentrations of nitrate.	Nitrates	100-107	ATZ20_RS04105	Sulfolobus acidocaldarius	4-10
3137069-3	1988	Evidence for nitrate induced PGI2 stimulation is presented by inhibition of its formation by indomethacin and dexamethasone, the demonstration of inhibition of thrombin induced thromboxane generation of washed platelet suspensions by nitrate stimulated vessel incubates and an enhanced accumulation of the hydrolysis product of PGI2, 6-oxo-PGF1 alpha, in incubates of teopranitol stimulated vessels.	Nitrates	13-20	coagulation factor II, thrombin	Bos taurus	160-168
3110273-0	1987	Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.	Nitrates	21-28	interferon gamma	Mus musculus	95-111
3110273-5	1987	Recombinant IFN-gamma also stimulated nitrite/nitrate synthesis by C3H/He and CeH/HeJ macrophages as did LPS (C3H/He only) and hk BCG.	Nitrates	46-53	interferon gamma	Mus musculus	12-21
3110273-6	1987	When given concurrently with either LPS or hk BCG, IFN-gamma enhanced C3H/He and C3H/HeJ macrophage nitrite/nitrate synthesis over that produced by macrophages treated with either LPS or hk BCG alone.	Nitrates	108-115	interferon gamma	Mus musculus	51-60
3110273-10	1987	Taken together, these results indicate that T cell lymphokines and IFN-gamma are powerful modulators of macrophage nitrite/nitrate synthesis during BCG infection and in vitro, and nitrite/nitrate synthesis appears to be common property of both primed and fully activated macrophage populations.	Nitrates	123-130	interferon gamma	Mus musculus	67-76
3553637-0	1987	Landmark article Sept 8, 1945: Cyanosis in infants caused by nitrates in well-water.	Nitrates	61-69	septin 8	Homo sapiens	17-23
2439225-2	1987	Murine peritoneal macrophages, elicited in vivo with thioglycolate and stimulated in vitro with LPS and/or gamma-interferon (IFN), produce copious amounts of nitrate and nitrite.	Nitrates	158-165	interferon gamma	Mus musculus	107-129
16665499-4	1987	Addition of nitrate to inactive nitrate reductase of mutant 305 caused the in vivo reactivation of the enzyme and halted its degradation.	Nitrates	12-19	uncharacterized protein	Chlamydomonas reinhardtii	32-49
2952501-7	1987	The ATPase activity is not inhibited by N,N"-dicyclohexylcarbodiimide, azide or vanadate, but it is by the vascular ATPase inhibitor nitrate with an [I]50 of 8 mM.	Nitrates	133-140	ATZ20_RS04105	Sulfolobus acidocaldarius	4-10
3314296-1	1987	(A) The effects of phosphate, chloride, nitrate, pyruvate, malate, succinate and glutamate ions on the kinetics of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) were studied with MgATP2- and 3-P-glycerate as variable substrates.	Nitrates	40-47	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	121-144
3314296-1	1987	(A) The effects of phosphate, chloride, nitrate, pyruvate, malate, succinate and glutamate ions on the kinetics of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3) were studied with MgATP2- and 3-P-glycerate as variable substrates.	Nitrates	40-47	F1F0 ATP synthase subunit gamma	Saccharomyces cerevisiae S288C	146-152
2952501-7	1987	The ATPase activity is not inhibited by N,N"-dicyclohexylcarbodiimide, azide or vanadate, but it is by the vascular ATPase inhibitor nitrate with an [I]50 of 8 mM.	Nitrates	133-140	ATZ20_RS04105	Sulfolobus acidocaldarius	116-122
16664862-10	1986	The results provide additional support to our claim that wild-type soybean contains three NR isozymes, namely, constitutive NADPH:NR (c(1)NR), constitutive NADH:NR (c(2)NR), and nitrate-inducible NR (iNR).	Nitrates	178-185	inducible nitrate reductase [NADH] 1	Glycine max	90-92
16347270-3	1987	Significant nitrate concentrations (1 to 27 muM) were observed in the sediment of Lake Vechten during the nonstratified period; the concentration profiles showed a successive depletion of oxygen, nitrate, and sulfate with depth.	Nitrates	12-19	latexin	Homo sapiens	44-47
3015963-2	1986	Besides the reduction of nitrate by NADH, nitrate reductase also catalyzes the partial activities NADH:cytochrome c reductase, NADH:ferricyanide reductase, and reduced methyl viologen:nitrate reductase.	Nitrates	25-32	nitrate reductase [NADH] 1	Zea mays	42-59
3015963-2	1986	Besides the reduction of nitrate by NADH, nitrate reductase also catalyzes the partial activities NADH:cytochrome c reductase, NADH:ferricyanide reductase, and reduced methyl viologen:nitrate reductase.	Nitrates	25-32	nitrate reductase [NADH] 1	Zea mays	184-201
16664862-5	1986	In vitro FMNH(2)-dependent nitrate reduction and Cyt c reductase activity of nitrate-grown plants, and nitrogenous gas evolution during in vivo NR assays of urea-grown plants, were also decreased in the mutants.	Nitrates	77-84	chalcone reductase CHR1	Glycine max	55-64
16665101-1	1986	Bromphenol blue, which was reduced with dithionite, was found to support nitrate reduction catalyzed by squash NADH:nitrate reductase at a rate about 5 times greater than NADH with freshly prepared enzyme and 10 times or more with enzyme having been frozen and thawed.	Nitrates	73-80	nitrate reductase [NADH] 1	Zea mays	116-133
16665101-2	1986	Kinetic analysis of bromphenol blue as a substrate for squash nitrate reductase yielded apparent K(m) values of 60 micromolar for bromphenol blue at 10 millimolar nitrate and 500 micromolar for nitrate at 0.2 millimolar bromphenol blue.	Nitrates	163-170	nitrate reductase [NADH] 1	Zea mays	62-79
3798854-1	1986	The quantitative determination of nitrate-reducing microorganisms in food is important because of their role in the formation of N-nitroso compounds and methemoglobin.	Nitrates	34-41	hemoglobin subunit gamma 2	Homo sapiens	153-166
3085308-10	1986	The effects of nitrates, nitrites and mechanisms of the reconversion of methemoglobin to hemoglobin are discussed.	Nitrates	15-23	HGB	Sus scrofa	75-85
3955002-4	1986	All of the ligands except for the halides, nitrate, and acetate form exclusively low-spin complexes in analogy to results obtained with the spectroscopically related protein, cytochrome P-450-CAM [Sono, M., &amp; Dawson, J.H.	Nitrates	43-50	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	175-191
16664678-4	1986	After 2 days of treatment with 10 millimolar nitrate, acetylene reduction by nodulated roots was inhibited by 48% but there was no effect on either acetylene reduction by isolated bacteroids or in vitro activity of nodule cytoplasmic glutamine synthetase, glutamine oxoglutarate aminotransferase, xanthine dehydrogenase, uricase, or allantoinase.	Nitrates	45-52	uricase-2 isozyme 1	Glycine max	321-328
16664640-9	1986	Western blots of polyacrylamide gels of native and denatured crude extracts showed that NADH:NR polypeptide was absent prior to treatment with N nutrients, but appeared after nitrate was given in dark or light.	Nitrates	175-182	nitrate reductase [NADH] 1	Zea mays	93-95
16664642-6	1986	Stem NO(3) (-) concentration and in vivo leaf NR activity were significantly correlated (R(2) = 0.69 with nitrate in the assay medium and 0.74 without nitrate in the medium at P = 0.001) across six combinations of reproductive and soil N-treatment.	Nitrates	106-113	inducible nitrate reductase [NADH] 1	Glycine max	46-48
16664642-6	1986	Stem NO(3) (-) concentration and in vivo leaf NR activity were significantly correlated (R(2) = 0.69 with nitrate in the assay medium and 0.74 without nitrate in the medium at P = 0.001) across six combinations of reproductive and soil N-treatment.	Nitrates	151-158	inducible nitrate reductase [NADH] 1	Glycine max	46-48
3754852-0	1986	The binding of plutonium to transferrin in the presence of tri-n-butyl phosphate or nitrate and its release by diethylenetriaminepenta-acetate and the tetrameric catechoylamide ligand LICAMC(C).	Nitrates	84-91	transferrin	Homo sapiens	28-39
11538660-5	1986	The nuclear NTPase activity was not inhibited by vanadate, oligomycin, or nitrate, but was inhibited by relatively low concentrations of quercetin and the calmodulin inhibitor, compound 48/80.	Nitrates	74-81	inosine triphosphatase	Homo sapiens	12-18
4079911-3	1985	For the organic nitrates, increases in the rate of reaction with cysteine, in general, ran parallel both with increases in pharmacological potency (flow in the Langendorff heart) and with increases in total clearance.	Nitrates	16-24	RAN, member RAS oncogene family	Homo sapiens	87-90