PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 7685581-5 1993 Since glutathionyl adducts of certain quinones can undergo redox cycling mediated by the human carbonyl reductase or rat DT-diaphorase, it is unlikely that the conjugation of one of these quinones with glutathione is sufficient to protect against quinone-mediated oxidative stress in cells which contain either of these enzymes. Quinones 38-46 dehydrogenase/reductase 4 Rattus norvegicus 95-113 7620214-7 1994 The complex interplay of the levels of oxygen and of DT-diaphorase governs the effectiveness of these agents and other quinones such as mitomycin C. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 7620217-0 1994 Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Quinones 17-25 NAD(P)H quinone dehydrogenase 1 Homo sapiens 29-42 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-46 7620221-1 1994 NAD(P)H:quinone oxidoreductase1 (DT-diaphorase or NQO1) is a flavoprotein that promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress, and neoplasia. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 50-54 8268208-9 1993 Lens epithelial cells were also checked for DT-diaphorase, a well-known cellular protective enzyme which can catalyze the two-electron reduction of quinones. Quinones 148-156 NAD(P)H dehydrogenase, quinone 1 Mus musculus 44-57 7690400-1 1993 NADPH-quinone reductase catalyzes the two-electron reduction of quinones such as menadione, and generally is considered to play a protective role against quinone-mediated toxicity. Quinones 64-72 crystallin zeta Rattus norvegicus 0-23 8395783-11 1993 Many genes are induced by TCDD, and many others are induced by electrophilic metabolites such as quinones and H2O2; using several mouse experimental systems, we have defined a subset of six of these genes as constituting the [Ah] battery by the sole criterion that a functional CYP1A1 or CYP1A2 enzyme is able to repress the expression of genes that are members of this gene battery. Quinones 97-105 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 278-284 8395783-11 1993 Many genes are induced by TCDD, and many others are induced by electrophilic metabolites such as quinones and H2O2; using several mouse experimental systems, we have defined a subset of six of these genes as constituting the [Ah] battery by the sole criterion that a functional CYP1A1 or CYP1A2 enzyme is able to repress the expression of genes that are members of this gene battery. Quinones 97-105 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 288-294 8168727-3 1993 The VP-16 molecule contains a hindered phenolic group which is crucial for its antitumor activity because its oxidation yields reactive metabolites (quinones) capable of irreversible binding to macromolecular targets. Quinones 149-157 host cell factor C1 Homo sapiens 4-9 8375023-0 1993 DT-diaphorase in activation and detoxification of quinones. Quinones 50-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 8461317-1 1993 NAD(P)H:quinone reductase, or DT-diaphorase, has been studied primarily in the liver where it appears to function as an antioxidant-like enzyme in the 2-electron reduction of some quinones to less toxic hydroquinones. Quinones 180-188 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 30-43 8433003-13 1993 The O-methylation of o-dihydroxyphenols and indols by catechol-O-methyltransferase localized in microsomes and cytoplasma prevents their oxidation to reactive quinones. Quinones 159-167 catechol-O-methyltransferase Homo sapiens 54-82 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 8375015-1 1993 NAD(P)H:Quinone Oxidoreductase1 (NQO1) also known as DT-diaphorase is a flavoprotein that catalyzes the two-electron reduction of quinones, quinone imines and azo-dyes and thereby protects cells against mutagenicity and carcinogenicity resulting from free radicals and toxic oxygen metabolites generated by the one-electron reductions catalyzed by cytochromes P450 and other enzymes. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 1324793-1 1992 The enzyme DT-diaphorase (DTD; NAD(P)H:quinone oxidoreductase, EC 1.6.99.2), is an obligate two electron reductase which catalyzes reduction of a broad range of substrates, including quinones. Quinones 183-191 NAD(P)H quinone dehydrogenase 1 Homo sapiens 11-24 1510692-2 1992 Sensitivity has been compared with the intra-cellular levels of DT-diaphorase, an enzyme thought to be important in the reductive activation of these quinones. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-77 1567483-7 1992 We suggest that the inhibition of TR by some antitumor quinones leading to a decreased activity of TR and, consequently, a decreased activity of thioredoxin-dependent enzymes including ribonucleotide reductase may contribute to the growth inhibitory activity of these quinones. Quinones 55-63 thioredoxin Homo sapiens 145-156 1567483-7 1992 We suggest that the inhibition of TR by some antitumor quinones leading to a decreased activity of TR and, consequently, a decreased activity of thioredoxin-dependent enzymes including ribonucleotide reductase may contribute to the growth inhibitory activity of these quinones. Quinones 268-276 thioredoxin Homo sapiens 145-156 1567482-4 1992 The antitumor quinones diaziquone and doxorubicin, and the quinoneimine 2,6-dichloroindophenol, were found to be inhibitors of the reduction of 5,5"-dithiobis-2-nitrobenzoic acid (DTNB) by TR. Quinones 14-22 peroxiredoxin 5 Rattus norvegicus 189-191 1714284-2 1991 NAD(P)H: (quinone-acceptor) oxidoreductase (quinone reductase, DT-diaphorase, EC 1.6.99.2) is an obligate 2-electron donating enzyme that can reduce a variety of quinones resulting either in bioactivation or bioprotection. Quinones 162-170 thioredoxin reductase 1 Homo sapiens 28-42 1540627-7 1992 This finding supported the involvement of zeta-crystallin bound NADPH in the in vivo enzymic reduction of quinones. Quinones 106-114 quinone oxidoreductase Cavia porcellus 42-57 1737339-1 1992 NAD(P)H:quinone oxidoreductase (DT-diaphorase; DTD) is an obligate two-electron reductase which may play a role in the bioactivation of antitumor quinones such as mitomycin C (MMC). Quinones 146-154 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-45 1372830-4 1992 The isoforms of DT-diaphorase showed broad substrate specificities towards four different quinones (menadione, vitamin K-1, benzo(a)pyrene 3,6-quinone and cyclized-dopamine ortho-quinone), although quantitative differences in the specific activities were also found. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 16-29 1310854-1 1992 Bioreductive activation of quinones in mammalian liver has generally been attributed to NADPH-cytochrome P450 reductase. Quinones 27-35 cytochrome p450 oxidoreductase Homo sapiens 88-119 1370456-5 1992 We report here that certain naturally occurring quinones are good substrates for the enzymatic activity of zeta-crystallin. Quinones 48-56 quinone oxidoreductase Cavia porcellus 107-122 1777518-1 1991 The interaction of quinones (menadione and duroquinone) with DT-diaphorase and mitochondrial electron transport chain translocators at low (120 mosM) and high (400 mosM) values of the medium tonicity in the quinone concentration range of 6-90 microM was studied. Quinones 19-27 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 1651729-1 1991 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein which catalyzes the two-electron reduction of quinones and azo-dyes and thus prevents the formation of free radicals and toxic oxygen metabolites that may be generated by the one-electron reductions catalyzed by cytochrome P450 reductase. Quinones 102-110 crystallin zeta Homo sapiens 8-30 1651729-1 1991 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoprotein which catalyzes the two-electron reduction of quinones and azo-dyes and thus prevents the formation of free radicals and toxic oxygen metabolites that may be generated by the one-electron reductions catalyzed by cytochrome P450 reductase. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 1714284-2 1991 NAD(P)H: (quinone-acceptor) oxidoreductase (quinone reductase, DT-diaphorase, EC 1.6.99.2) is an obligate 2-electron donating enzyme that can reduce a variety of quinones resulting either in bioactivation or bioprotection. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-76 1997095-5 1991 As a possible mechanism that might account for this action, it may be that 4-S-CAP is oxidised by tyrosinase to the o-quinone form via the catechol derivative and that some of the quinones then conjugate with sulfhydryl enzymes including DNA polymerase, thus exerting a killing activity for pigmented melanoma cells. Quinones 180-188 tyrosinase Mus musculus 98-108 1720333-0 1991 Stimulation of insulin release from pancreatic islets by quinones. Quinones 57-65 insulin Homo sapiens 15-22 1720333-1 1991 Coenzyme Q (CoQ0) and other quinones were shown to be potent insulin secretagogues in the isolated pancreatic islet. Quinones 28-36 insulin Homo sapiens 61-68 1720333-8 1991 Quinones may stimulate insulin release by mimicking physiologically-occurring quinones, such as CoQ10, by acting on the plasma membrane or in the cytosol. Quinones 0-8 insulin Homo sapiens 23-30 1720333-8 1991 Quinones may stimulate insulin release by mimicking physiologically-occurring quinones, such as CoQ10, by acting on the plasma membrane or in the cytosol. Quinones 78-86 insulin Homo sapiens 23-30 1923701-1 1991 Quinones can be metabolized by various routes: substitution or reductive addition with nucleophilic compounds (mainly glutathione and protein thiol groups), one-electron reduction (mainly by NADPH: cytochrome P-450 reductase) and two-electron reduction (by D,T-diaphorase). Quinones 0-8 2,4-dienoyl-CoA reductase 1 Homo sapiens 191-196 2043155-1 1991 The quinones tetrachloro-1,4-benzoquinone (1,4-TCBQ) and its glutathione conjugate (GS-1,4-TCBQ) are potent irreversible inhibitors of most human glutathione S-transferase (GST) isoenzymes. Quinones 4-12 glutathione S-transferase kappa 1 Homo sapiens 146-171 2043155-1 1991 The quinones tetrachloro-1,4-benzoquinone (1,4-TCBQ) and its glutathione conjugate (GS-1,4-TCBQ) are potent irreversible inhibitors of most human glutathione S-transferase (GST) isoenzymes. Quinones 4-12 glutathione S-transferase kappa 1 Homo sapiens 173-176 2119908-0 1990 Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones. Quinones 78-86 ornithine decarboxylase, structural 1 Mus musculus 10-33 2134835-0 1990 NBS bromination reactions of dihydronaphthofuran quinones: a new fragmentation type reaction in the chemistry of quinones. Quinones 49-57 nibrin Homo sapiens 0-3 1899380-1 1991 NAD(P)H: quinone oxidoreductase (NQO1) is believed to be protective against cancer and toxicity caused by exposure to quinones and their metabolic precursors. Quinones 118-126 crystallin zeta Homo sapiens 9-31 1899380-1 1991 NAD(P)H: quinone oxidoreductase (NQO1) is believed to be protective against cancer and toxicity caused by exposure to quinones and their metabolic precursors. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 1899380-6 1991 263, 13572-13578] and provided preliminary evidence that this enzyme may correspond to diaphorase 4, an enzymatic activity present in various tissues that catalyzes the reduction of a variety of quinones by both NADH and NADPH [Edwards et al. Quinones 195-203 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-99 2119908-9 1990 Thus, there was a good correlation between the ability of structurally related quinones to induce epidermal ODC and their ability to behave as tumor promoters. Quinones 79-87 ornithine decarboxylase, structural 1 Mus musculus 108-111 2119908-5 1990 These two quinones also promoted papilloma formation in female SENCAR mice initiated with 25 nmol 7,12-dimethylbenz[a]anthracene at doses capable of inducing epidermal ODC. Quinones 10-18 ornithine decarboxylase, structural 1 Mus musculus 168-171 2375745-14 1990 A three-step mechanism for a mixed one-electron and two-electron reduction of quinones by lipoamide dehydrogenase is proposed. Quinones 78-86 dihydrolipoamide dehydrogenase Sus scrofa 90-113 2307529-1 1990 NAD(P)H:(quinone-acceptor)oxidoreductase (QAO), previously known as DT-diaphorase, catalyzes the reduction of quinones to hydroquinones. Quinones 110-118 NAD(P)H quinone dehydrogenase 1 Homo sapiens 68-81 2162450-9 1990 Basal peroxidatic activity of cytochrome P-450, the enzyme which oxidizes estrogen hydroquinones to quinones in the redox cycle, was 2.5-fold higher in liver than in kidney and did not change with estrogen treatment. Quinones 88-96 cytochrome P450 2A3-like Mesocricetus auratus 30-46 2162450-11 1990 The activity of cytochrome P-450 reductase, which reduces quinones to hydroquinones in the estrogen redox cycle, was 6-fold higher in liver than in kidney of both control and estrogen-treated animals. Quinones 58-66 cytochrome P450 2A3-like Mesocricetus auratus 16-32 2160607-5 1990 (2) The catecholestrogen or diethylstilbestrol (DES) are oxidized to semiquinones and quinones by the peroxidatic activity of cytochrome P-450. Quinones 73-81 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 126-142 2113027-0 1990 On the mechanism of one-electron reduction of quinones by microsomal flavin enzymes: the kinetic analysis between cytochrome B5 and menadione. Quinones 46-54 cytochrome b5 type A Homo sapiens 114-127 2154955-5 1990 This is also confirmed by the effect of superoxide dismutase (SOD): in the presence of a BABQ derivative, cytochrome c reduction can be totally inhibited by SOD, although the required amount of SOD depends on the redox potential of the quinones. Quinones 236-244 superoxide dismutase 1 Homo sapiens 40-60 2154955-5 1990 This is also confirmed by the effect of superoxide dismutase (SOD): in the presence of a BABQ derivative, cytochrome c reduction can be totally inhibited by SOD, although the required amount of SOD depends on the redox potential of the quinones. Quinones 236-244 superoxide dismutase 1 Homo sapiens 62-65 2154955-5 1990 This is also confirmed by the effect of superoxide dismutase (SOD): in the presence of a BABQ derivative, cytochrome c reduction can be totally inhibited by SOD, although the required amount of SOD depends on the redox potential of the quinones. Quinones 236-244 cytochrome c, somatic Homo sapiens 106-118 2154955-5 1990 This is also confirmed by the effect of superoxide dismutase (SOD): in the presence of a BABQ derivative, cytochrome c reduction can be totally inhibited by SOD, although the required amount of SOD depends on the redox potential of the quinones. Quinones 236-244 superoxide dismutase 1 Homo sapiens 157-160 2154955-5 1990 This is also confirmed by the effect of superoxide dismutase (SOD): in the presence of a BABQ derivative, cytochrome c reduction can be totally inhibited by SOD, although the required amount of SOD depends on the redox potential of the quinones. Quinones 236-244 superoxide dismutase 1 Homo sapiens 157-160 2162313-10 1990 The results suggest that inhibition of TR by antitumor quinones could contribute to their growth inhibitory properties. Quinones 55-63 peroxiredoxin 5 Homo sapiens 39-41 2113030-0 1990 Activation and deactivation of quinones catalyzed by DT-diaphorase. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 33819425-0 2021 Sc(OTf)3-Catalyzed Formal [3 + 3] Cycloaddition Reaction of Diaziridines and Quinones for the Synthesis of Benzo[e][1,3,4]oxadiazines. Quinones 77-85 POU class 5 homeobox 1 Homo sapiens 0-8 33819425-2 2021 The reaction was catalyzed by Sc(OTf)3 with a large substrate scope for both diaziridines and quinones. Quinones 94-102 POU class 5 homeobox 1 Homo sapiens 30-38 33777113-1 2021 Background: We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones. Quinones 182-190 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 33-61 33777113-1 2021 Background: We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones. Quinones 182-190 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 63-67 34356648-2 2021 Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. Quinones 266-274 NAD(P)H quinone dehydrogenase 1 Homo sapiens 195-199 34569134-0 2021 Biomimetic Recognition of Quinones in Water by an Endo-Functionalized Cavity with Anthracene Sidewalls. Quinones 26-34 mannosidase endo-alpha Homo sapiens 50-54 34252539-3 2021 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the reduction and detoxification of quinones and other organic compounds. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 34252539-3 2021 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the reduction and detoxification of quinones and other organic compounds. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 34833955-1 2021 NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. Quinones 168-176 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-41 34833955-1 2021 NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes. Quinones 168-176 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 34280084-7 2021 The respiratory quinones comprised MK8(H2) (10.8 %) and MK9(H2) (89.2 %) for strain zg-686T, and MK6 (7.7 %), MK8(H2) (8.4 %), MK8(H4) (3.1 %) and MK9(H2) (80.8 %) for strain HY186T. Quinones 16-24 relaxin 2 Homo sapiens 35-41 2539822-8 1989 DT-diaphorase activity and intracellular glutathione were found to protect the cells from the toxicity of both quinones. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 2548593-3 1989 Autoxidation of the catechol yields the primary semiquinone together with the primary molecular product VP-16 quinone, which subsequently undergoes hydrolytic oxidation to form secondary quinones and semiquinones. Quinones 187-195 host cell factor C1 Homo sapiens 104-109 35202787-4 2022 We show that all three quinones concentration-dependently catalyze the oxidization of H2S to polysulfides and thiosulfate in buffer with the potency CoQ0>CoQ1>CoQ10 and that CoQ0 specifically oxidizes H2S to per-polysulfides, H2S2,3,4. Quinones 23-31 decaprenyl diphosphate synthase subunit 1 Homo sapiens 154-158 35202787-5 2022 These reactions consume and require oxygen and are augmented by addition of SOD suggesting that the quinones, not superoxide, oxidize H2S. Quinones 100-108 superoxide dismutase 1 Homo sapiens 76-79 35055166-1 2022 Neuronal nitric oxide synthase (nNOS) catalyzes single-electron reduction of quinones (Q), nitroaromatic compounds (ArNO2) and aromatic N-oxides (ArN O), and is partly responsible for their oxidative stress-type cytotoxicity. Quinones 77-85 nitric oxide synthase 1 Homo sapiens 0-30 35055166-1 2022 Neuronal nitric oxide synthase (nNOS) catalyzes single-electron reduction of quinones (Q), nitroaromatic compounds (ArNO2) and aromatic N-oxides (ArN O), and is partly responsible for their oxidative stress-type cytotoxicity. Quinones 77-85 nitric oxide synthase 1 Homo sapiens 32-36 35055166-1 2022 Neuronal nitric oxide synthase (nNOS) catalyzes single-electron reduction of quinones (Q), nitroaromatic compounds (ArNO2) and aromatic N-oxides (ArN O), and is partly responsible for their oxidative stress-type cytotoxicity. Quinones 87-88 nitric oxide synthase 1 Homo sapiens 0-30 35055166-1 2022 Neuronal nitric oxide synthase (nNOS) catalyzes single-electron reduction of quinones (Q), nitroaromatic compounds (ArNO2) and aromatic N-oxides (ArN O), and is partly responsible for their oxidative stress-type cytotoxicity. Quinones 87-88 nitric oxide synthase 1 Homo sapiens 32-36 35055166-3 2022 In the absence or presence of calmodulin (CAM), the reactivity of Q and ArN O increases with their single-electron reduction midpoint potential (E17). Quinones 66-67 calmodulin 1 Homo sapiens 30-40 35055166-3 2022 In the absence or presence of calmodulin (CAM), the reactivity of Q and ArN O increases with their single-electron reduction midpoint potential (E17). Quinones 66-67 calmodulin 1 Homo sapiens 42-45 3129984-1 1988 DT diaphorase catalyzes the transfer of two electrons to quinones to form relatively stable hydroquinones, thus protecting cells from damage by semiquinone production and subsequent superoxide radical formation. Quinones 57-65 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-13 2846069-1 1988 Tyrosinase usually catalyzes the conversion of monophenols to o-diphenols and the oxidation of o-diphenols to the corresponding quinones. Quinones 128-136 tyrosinase Homo sapiens 0-10 3136917-10 1988 Spectrophotometric data indicated that Compounds 1 and 2 were oxidized by tyrosinase to quinones. Quinones 88-96 tyrosinase Homo sapiens 74-84 2843525-2 1988 NAD(P)H:menadione oxidoreductase (NMOR1) is a flavoprotein that catalyzes the two-electron reduction of various redox dyes and quinones. Quinones 127-135 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-39 2844120-0 1988 Reduction of exogenous quinones and 2,6-dichlorophenol indophenol in cytochrome b-deficient yeast mitochondria: a differential effect on center i and center o of the cytochrome b-c1 complex. Quinones 23-31 cytochrome b Saccharomyces cerevisiae S288C 69-81 2844120-0 1988 Reduction of exogenous quinones and 2,6-dichlorophenol indophenol in cytochrome b-deficient yeast mitochondria: a differential effect on center i and center o of the cytochrome b-c1 complex. Quinones 23-31 cytochrome b Saccharomyces cerevisiae S288C 166-178 2455523-4 1988 Induction of DT-diaphorase by Sudan III or MCA was associated with protection against the cytotoxicity of quinones as measured by a colony survival assay. Quinones 106-114 NAD(P)H dehydrogenase, quinone 1 Mus musculus 13-26 2455523-5 1988 When control and induced cells were also exposed to dicoumarol, a specific and potent inhibitor of DT-diaphorase, the cytotoxicity of the quinones in both control and induced cells was enhanced markedly. Quinones 138-146 NAD(P)H dehydrogenase, quinone 1 Mus musculus 99-112 2455523-6 1988 The results support the hypothesis that DT-diaphorase competes with one-electron quinone-reducing enzymes (such as cytochrome P-450 reductase) which generate auto-oxidizable semiquinones and forms more stable hydroquinones as an initial step in the detoxification of quinones in 10T1/2 cells. Quinones 178-186 NAD(P)H dehydrogenase, quinone 1 Mus musculus 40-53 2837229-10 1988 At a low concentration of CHP (0.10 mM), BP was metabolized to phenols and quinones, whereas 6-FBP gave only quinones. Quinones 109-117 far upstream element binding protein 1 Rattus norvegicus 95-98 2837229-14 1988 Reaction of BP and 6-FBP radical cation perchlorates with water produced the same BP quinones. Quinones 85-93 far upstream element binding protein 1 Rattus norvegicus 21-24 2846950-8 1988 We hypothesize that reduction of cytochrome c by oral mucosa of smokers and patients with mouth cancer is primarily due to residues of cigarette tar containing conjugated quinones of mixed oxidative states which are strong reductants as well as producers of oxygen-centered radicals. Quinones 171-179 cytochrome c, somatic Homo sapiens 33-45 2826438-0 1988 Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones. Quinones 174-182 oxidoreductase Saccharomyces cerevisiae S288C 49-63 2826438-0 1988 Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones. Quinones 174-182 oxidoreductase Saccharomyces cerevisiae S288C 86-100 2826438-0 1988 Direct interaction between yeast NADH-ubiquinone oxidoreductase, succinate-ubiquinone oxidoreductase, and ubiquinol-cytochrome c oxidoreductase in the reduction of exogenous quinones. Quinones 174-182 oxidoreductase Saccharomyces cerevisiae S288C 86-100 3127037-5 1988 The origin of soluble tyrosinase and its utility to employ that enzymatic activity in melanoma chemotherapy using catechols as tyrosinase-dependent precursors of cytotoxic quinones is discussed. Quinones 172-180 tyrosinase Mus musculus 22-32 3127037-5 1988 The origin of soluble tyrosinase and its utility to employ that enzymatic activity in melanoma chemotherapy using catechols as tyrosinase-dependent precursors of cytotoxic quinones is discussed. Quinones 172-180 tyrosinase Mus musculus 127-137 3576723-7 1987 The quinones are reduced by lipoamide dehydrogenase in the one-electron mechanism. Quinones 4-12 dihydrolipoamide dehydrogenase Homo sapiens 28-51 3593796-5 1987 Superoxide dismutase, Cu2+ and catalase inhibit the CN-resistant respiration in the presence of quinones. Quinones 96-104 catalase Rattus norvegicus 31-39 3593793-1 1987 The reactions of NADPH oxidation by quinones and inorganic complexes catalyzed by NADPH: adrenodoxin reductase were studied. Quinones 36-44 ferredoxin reductase Homo sapiens 89-110 3541787-3 1986 Typical of similar enzymes in other species, gerbil AR1 reduced aliphatic and aromatic aldehydes and was inhibited by phenobarbital or valproate, whereas CR1 and CR2 catalyzed the reduction of aromatic aldehydes and ketones as well as quinones and were inhibited by p-chloromercuribenzoate, mercuric chloride, or pyrazole. Quinones 235-243 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 154-157 3303039-6 1987 These properties, coupled with the activity of CBR with a range of aliphatic and aromatic aldehydes, ketones and quinones, distinguish it from other AHRs. Quinones 113-121 carbonyl reductase 1 Mus musculus 47-50 2419007-5 1986 NADPH-cytochrome P-450 reductase and similar flavo-enzymes activate quinones via one-electron reduction into semiquinone free radicals, which then react with molecular oxygen, forming superoxide anions. Quinones 68-76 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 0-32 3023079-10 1986 However, the addition of both these inhibitors together completely blocks the oxidation of cytochrome b by quinones. Quinones 107-115 mitochondrially encoded cytochrome b Homo sapiens 91-103 3767971-2 1986 This stimulation was most marked with Glu 80 Tyr 20, has an absolute requirement for either dithiothreitol or reduced glutathione, and was inhibited by superoxide dismutase, catalase, and desferrioxamine to varying degrees depending on the quinones used. Quinones 240-248 catalase Rattus norvegicus 174-182 3746818-0 1986 Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2"-deoxyuridine 5"-phosphate. Quinones 18-26 thymidylate synthetase Homo sapiens 68-88 2425252-4 1986 The presence of dicumarol, a specific inhibitor of the two-electron reduction of quinones by DT-diaphorase, afforded some protection against cytotoxicity. Quinones 81-89 NAD(P)H quinone dehydrogenase 1 Homo sapiens 93-106 3096849-1 1986 DT-diaphorase (DTD) is a flavoprotein that catalyses the two-electron reduction of various redox dyes and quinones such as menadione and phylloquinone. Quinones 106-114 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-13 2419007-7 1986 Since UBTE contains substantial activities of prostaglandin H synthase (PHS) and NADPH-cytochrome P-450 reductase, unlike UBNT, the toxicity and carcinogenicity of xenobiotics which are either quinones or form quinones in situ through the mediation of PHS would be high in UBTE. Quinones 210-218 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 81-113 2419007-8 1986 The risk of carcinogenicity of quinones in UBTE would be higher in male rabbits than in female rabbits due to sex-dependent differences in the relative proportions of the one-electron reduction pathway, represented by NADPH-cytochrome P-450 reductase, and the two-electron reduction pathway, represented by DT-diaphorase (female greater than male). Quinones 31-39 NADPH--cytochrome P450 reductase Oryctolagus cuniculus 218-250 4060194-3 1985 In fibroblasts, effects on both DNA and membrane integrity were potentiated by the presence of dicoumarol, a specific inhibitor of the 2-electron reduction of quinones by DT-diaphorase, whereas in hepatocytes only the cell membrane damage was sensitive to dicoumarol. Quinones 159-167 NAD(P)H quinone dehydrogenase 1 Homo sapiens 171-184 2869525-2 1985 In vertebrates tyrosinase is present only in specialized cells (melanocytes), where it catalyses the oxidation of tyrosine and certain diphenolic intermediate products to quinones which polymerize to give rise to melanin. Quinones 171-179 tyrosinase Homo sapiens 15-25 6523136-5 1984 The interaction of quinones, o-chloranil and chlorophenoxyalkyl acids with the GST activity, in extracts from three different macro-invertebrates, revealed an inhibition which was quite similar to that previously found for rat liver GST. Quinones 19-27 hematopoietic prostaglandin D synthase Rattus norvegicus 79-82 4016732-7 1985 When the substrate concentration was 4 microM and the incubation time was 24 h, beta-glucuronidase treatment of water-soluble metabolites released about 5.3 times more pmol of quinones compared with phenols. Quinones 176-184 glucuronidase, beta Mus musculus 80-98 6523136-5 1984 The interaction of quinones, o-chloranil and chlorophenoxyalkyl acids with the GST activity, in extracts from three different macro-invertebrates, revealed an inhibition which was quite similar to that previously found for rat liver GST. Quinones 19-27 hematopoietic prostaglandin D synthase Rattus norvegicus 233-236 6089259-1 1984 It was shown that gamma-radiation-induced oxidation of phenol compounds in the animal liver, which leads to o-dioxyphenols and quinones accretion, is one of the reasons for excluding cytochrome c from the respiratory chain of mitochondria. Quinones 127-135 cytochrome c, somatic Homo sapiens 183-195 6295574-4 1982 It has been postulated that quinones too participate in the O-.2-forming reaction, but further work is necessary to define their role more fully. Quinones 28-36 immunoglobulin kappa variable 1D-39 Homo sapiens 60-64 6584903-3 1984 The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-93 6584903-3 1984 The two-electron reduction of these quinones by NAD(P)H-quinone oxidoreductase (DT-diaphorase) was not mutagenic, whereas the one-electron reduction, catalyzed by NADPH-cytochrome P-450 reductase, was mutagenic, except for danthron, which was only slightly mutagenic. Quinones 36-44 cytochrome p450 oxidoreductase Homo sapiens 163-195 6584903-5 1984 The cytochrome P-450 monooxygenase also played a significant role in the detoxification and bioactivation of these quinones. Quinones 115-123 cytochrome P450 family 20 subfamily A member 1 Homo sapiens 4-34 6309378-6 1983 Benzo(a)pyrene was metabolized by AHH to dihydrodiols, quinones, and phenols in quantities which were about 10 times greater than those reported for rat lung microsomes. Quinones 55-63 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 34-37 6313461-7 1983 Finally, cytosolic DT diaphorase, which carries out a two-electron reduction of quinones to more stable hydroquinones, may compete with the one-electron systems and participate in the detoxification of quinones by supplying hydroquinones for conjugation reactions. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 19-32 6313461-7 1983 Finally, cytosolic DT diaphorase, which carries out a two-electron reduction of quinones to more stable hydroquinones, may compete with the one-electron systems and participate in the detoxification of quinones by supplying hydroquinones for conjugation reactions. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 19-32 6187345-0 1983 Possible role of DT-diaphorase in the bioactivation of antitumor quinones. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 17-30 6187345-4 1983 Homogenates of rat 9L cells were found to contain relatively high levels of DT-diaphorase, suggesting that these tumor cells may be relatively sensitive to antitumor quinones that are activated by this enzyme. Quinones 166-174 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 76-89 6181068-3 1982 The two-electron reduction of quinones to diols, mediated by DT-diaphorase (NAD(P)H: (quinone-acceptor) oxidoreductase), may therefore represent a detoxifying pathway which protects the cell from the formation of these reactive intermediates. Quinones 30-38 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 6173137-0 1981 Inhibition of reverse transcriptase by tyrosinase generated quinones related to levodopa and dopamine. Quinones 60-68 tyrosinase Homo sapiens 39-49 6815478-8 1982 This mechanism differs markedly from that for inhibition of drug metabolism by other quinones, such as menadione, in which accelerated electron flow through P-450 reductase to the quinone diverts reducing equivalents from cytochrome P-450. Quinones 85-93 cytochrome P-450 Oryctolagus cuniculus 222-238 6180607-1 1982 NAD(P)H:quinone reductase exhibits broad specificity in the reduction of endogenous and exogenous quinones and quinone imines, such as those derived from polycyclic aromatic carcinogens, phenolic steroids, vitamin K, and numerous therapeutic drugs. Quinones 98-106 crystallin, zeta Mus musculus 8-25 6180607-10 1982 The broad specificity of quinone reductase, its apparent inability to catalyze one electron reductions of quinones, its widespread distribution, and its inducibility by a variety of structurally dissimilar protective compounds, suggest that quinone reductase may play a significant local protective role in various regions of the cell. Quinones 106-114 crystallin, zeta Mus musculus 25-42 6180607-10 1982 The broad specificity of quinone reductase, its apparent inability to catalyze one electron reductions of quinones, its widespread distribution, and its inducibility by a variety of structurally dissimilar protective compounds, suggest that quinone reductase may play a significant local protective role in various regions of the cell. Quinones 106-114 crystallin, zeta Mus musculus 241-258 7197750-5 1981 Such observations might explain the lower efficiency of short-chain quinones, as compared to the long-chain analogues, in restoring, in vitro, the respiratory activity of CoQ2-depleted mitochondria. Quinones 68-76 coenzyme Q2, polyprenyltransferase Homo sapiens 171-175 6933553-8 1980 NAD(P)H:quinone reductase exhibits broad specificity for structurally diverse hydrophobic quinones and may facilitate the microsomal metabolism of quinones to readily excreted conjugates. Quinones 90-98 crystallin, zeta Mus musculus 8-25 6933553-8 1980 NAD(P)H:quinone reductase exhibits broad specificity for structurally diverse hydrophobic quinones and may facilitate the microsomal metabolism of quinones to readily excreted conjugates. Quinones 147-155 crystallin, zeta Mus musculus 8-25 4356405-0 1973 [Reduction of cytochrome C in the presence of quinones; effect of light]. Quinones 46-54 cytochrome c, somatic Homo sapiens 14-26 4365609-0 1974 [Photosensitization of cytochrome C transformations by chlorophyll: activating effect of quinones]. Quinones 89-97 cytochrome c, somatic Homo sapiens 23-35 5142863-0 1971 [Catalytic acceleration by polyphenols and quinones of methemoglobin degradation in human erythrocytes]. Quinones 43-51 hemoglobin subunit gamma 2 Homo sapiens 55-68 4993020-0 1970 The role of the quinones prepared after oxidation of some amines by ceruloplasmin in the mitochondrial electron transport system. Quinones 16-24 ceruloplasmin Homo sapiens 68-81 14285230-0 1965 PHOTOREACTIONS OF CHLOROPLASTS AND CHLOROPHYLL A WITH HYDROQUINONES AND QUINONES: COUPLED PHOTOREDUCTION OF CYTOCHROME C. Quinones 59-67 cytochrome c, somatic Homo sapiens 108-120 4221488-0 1965 Effect of quinones on mitochondrial phosphorylation, Pi-ATP exchange, and ATPase activities. Quinones 10-18 dynein axonemal heavy chain 8 Homo sapiens 74-80 33774477-3 2021 Exogenous substrates for NQO1 include many xenobiotic quinones. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-29 32958393-7 2021 Inner membrane (IM) quinones (i.e., ubiquinone and menaquinone), IM quinone-reactive hydrogenase Hya, and IM-bound quinone reductase CymA are involved in hydrogen-dependent current generation, suggesting that the redox cycling of IM quinones catalyzed by Hya and CymA contributes to the generation of the proton motive force and the synthesis of ATP via F0F1-ATPase. Quinones 20-28 cytochrome c Shewanella oneidensis MR-1 263-267 33823775-8 2021 Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control. Quinones 137-145 insulin Homo sapiens 197-204 33439630-1 2021 This work highlights the use of push-pull hydroxylphenylpolyenylpyridinium fluorophores coupled with trimethyl lock quinone to engineer the ratiometric two-photon probes for cellular and intravital imaging of mitochondrial NAD(P)H:quinone oxidoreductase 1 (NQO1), a critical antioxidant enzyme responsible for detoxifying quinones. Quinones 322-330 NAD(P)H dehydrogenase, quinone 1 Mus musculus 223-255 33483563-6 2021 Substrate screening suggested that VAT-1 possesses oxidoreductase activity against quinones such as 1,2-naphthoquinone and 9,10-phenanthrenequinone. Quinones 83-91 vesicle amine transport 1 Homo sapiens 35-40 33483563-6 2021 Substrate screening suggested that VAT-1 possesses oxidoreductase activity against quinones such as 1,2-naphthoquinone and 9,10-phenanthrenequinone. Quinones 83-91 thioredoxin reductase 1 Homo sapiens 51-65 33023449-2 2021 CYP1A1/1B1 also participate in the metabolism of endogenous 17-beta-estradiol, producing estradiol hydroquinones which are the intermediates of carcinogenic semiquinones and quinones. Quinones 104-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-10 32942970-8 2021 According to the structural features, the natural COX-2 inhibitors were mainly divided into the following categories: natural phenols, flavonoids, stilbenes, terpenoids, quinones and alkaloids. Quinones 170-178 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 33196163-5 2020 In contrast, it was only the surface integrated quinones (Q) in sp2-bonded carbon regions of the BDD electrode that were responsible for the voltammetric pH signal. Quinones 48-56 Sp2 transcription factor Homo sapiens 64-67 33196163-5 2020 In contrast, it was only the surface integrated quinones (Q) in sp2-bonded carbon regions of the BDD electrode that were responsible for the voltammetric pH signal. Quinones 58-59 Sp2 transcription factor Homo sapiens 64-67 33140638-5 2020 After thoroughly characterizing the pretreatment parameters using outer-sphere and inner-sphere redox couples, we measured pH by reducing the surface-bound quinones, which undergo a pH-dependent 2e-/2H+ reduction. Quinones 156-164 phenylalanine hydroxylase Homo sapiens 123-125 33140638-5 2020 After thoroughly characterizing the pretreatment parameters using outer-sphere and inner-sphere redox couples, we measured pH by reducing the surface-bound quinones, which undergo a pH-dependent 2e-/2H+ reduction. Quinones 156-164 phenylalanine hydroxylase Homo sapiens 182-184 32986415-3 2020 In this study hop extract and its bioactive compounds were investigated for its mechanism of action within the chemical estrogen carcinogenesis pathway, which is mainly mediated through the 4-hydroxylation pathway catalyzed by CYP1B1 that can form gentoxic quinones. Quinones 257-265 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 227-233 32667050-0 2020 Quinones as preventive agents in Alzheimer"s diseases: focus on NLRP3 inflammasomes. Quinones 0-8 NLR family pyrin domain containing 3 Homo sapiens 64-69 32232985-3 2020 Here, PON1 was purified using very simple methods and evaluation of the interactions between the enzyme and some quinones. Quinones 113-121 paraoxonase 1 Homo sapiens 6-10 33313330-1 2020 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 33313330-1 2020 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 32799638-3 2021 Molecular docking results indicated that some favorable interactions of key amino acid residues at the binding site of Hsp90 with these quinones would be responsible for the inhibition of Hsp90 activity. Quinones 136-144 heat shock protein 90 alpha family class A member 1 Homo sapiens 119-124 32799638-3 2021 Molecular docking results indicated that some favorable interactions of key amino acid residues at the binding site of Hsp90 with these quinones would be responsible for the inhibition of Hsp90 activity. Quinones 136-144 heat shock protein 90 alpha family class A member 1 Homo sapiens 188-193 32903408-7 2020 In fact, several polyphenols, catechins, quinones, and peptides obtained from natural sources (including nuts, oils, root extracts, and fungi metabolites) have been described as promising KATi. Quinones 41-49 kynurenine aminotransferase 1 Homo sapiens 188-192 32232985-4 2020 It was found that these quinones displayed effective inhibitor properties for PON1 with the IC50 values in the range of 3.27-82.90 muM and the K i values in the range of 2.50 +- 0.65 to 30.90 +- 7.20 muM. Quinones 24-32 paraoxonase 1 Homo sapiens 78-82 32232985-4 2020 It was found that these quinones displayed effective inhibitor properties for PON1 with the IC50 values in the range of 3.27-82.90 muM and the K i values in the range of 2.50 +- 0.65 to 30.90 +- 7.20 muM. Quinones 24-32 latexin Homo sapiens 131-134 32232985-4 2020 It was found that these quinones displayed effective inhibitor properties for PON1 with the IC50 values in the range of 3.27-82.90 muM and the K i values in the range of 2.50 +- 0.65 to 30.90 +- 7.20 muM. Quinones 24-32 latexin Homo sapiens 200-203 32165217-1 2020 The NAD(P)H:quinone oxidoreductase 1 (NQO1) gene encodes a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 126-134 NAD(P)H dehydrogenase, quinone 1 Mus musculus 4-36 32678225-7 2020 These two groups were separable using albumin adducts of estrogen quinones and naphthoquinones, with 99.6% overall correct classification rate (overall accuracy). Quinones 66-74 albumin Homo sapiens 38-45 32336668-6 2020 Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. Quinones 114-122 NFE2 like bZIP transcription factor 2 Homo sapiens 22-26 32220725-8 2020 Fe showed synergistic with quinones in investigated concentration range (from 0.01 to 5 muM). Quinones 27-35 latexin Homo sapiens 88-91 32684991-2 2020 N-acetylcysteine (NAC 0.2% w/v) was added as an antioxidant, preventing the oxidation of NDGA to toxic quinones. Quinones 103-111 synuclein alpha Homo sapiens 18-21 32165217-1 2020 The NAD(P)H:quinone oxidoreductase 1 (NQO1) gene encodes a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 126-134 NAD(P)H dehydrogenase, quinone 1 Mus musculus 38-42 32350039-17 2020 Combination therapy with drugs able to safely induce NQO1 in neurons, as well as other brain cell types, may be able to unlock the neuroprotective therapeutic potential of idebenone or related quinones. Quinones 193-201 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 53-57 32049076-0 2020 Stacked hexagonal prism of Ag@Ni-MOF-1 as functionalized SERS platform through rational integration of catalytic synthesis of dopamine-quinone at physiological pH with a biomimetic route. Quinones 135-142 seryl-tRNA synthetase 1 Homo sapiens 57-61 31775023-5 2020 A recent study suggested that the cytosolic enzyme NAD(P)H: quinone acceptor oxidoreductase (NQO1) is the major enzyme involved in the activation of idebenone, and the beneficial effects of idebenone are dependent on the expression of NQO1. Quinones 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 93-97 31775023-5 2020 A recent study suggested that the cytosolic enzyme NAD(P)H: quinone acceptor oxidoreductase (NQO1) is the major enzyme involved in the activation of idebenone, and the beneficial effects of idebenone are dependent on the expression of NQO1. Quinones 60-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 235-239 32032607-6 2020 KKPA4026 was confirmed to induce the expression of the Nrf2-dependent antioxidant enzymes heme oxygenase-1, glutamate-cysteine ligase catalytic subunit, glutamate-cysteine ligase regulatory subunit, and NAD(P)H:quinone oxidoreductase 1 in BV-2 cells. Quinones 211-218 nuclear factor, erythroid derived 2, like 2 Mus musculus 55-59 31821902-3 2020 In addition to this oxidase activity, POx shows pronounced activity with alternative electron acceptors that include various quinones or (complexed) metal ions. Quinones 125-133 proline dehydrogenase 1 Homo sapiens 38-41 32049076-1 2020 Herein, a novel stacked hexagonal prism, Ag@Ni-MOF-1, was designed and developed as an integrated SERS platform not only for successfully catalyzing the in situ synthesis of DA-quinone under physiological pH, but also for establishing an approach for specific determination of Cys, an important species in the brain related to Alzheimer"s disease (AD). Quinones 177-184 seryl-tRNA synthetase 1 Homo sapiens 98-102 31935063-4 2020 After internalization into NQO1-positive vesicles, cytosolic NQO1 enzyme triggers self-immolative cleavage of quinone linkages and fluorogenic release of conjugated photosensitizers, leading to NIR fluorescence emission turn-on and activated PDT. Quinones 110-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 32040259-2 2020 The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Quinones 112-119 acyl-Coenzyme A oxidase 1, palmitoyl Mus musculus 4-23 32040259-2 2020 The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Quinones 112-119 acyl-Coenzyme A oxidase 1, palmitoyl Mus musculus 25-28 31935063-4 2020 After internalization into NQO1-positive vesicles, cytosolic NQO1 enzyme triggers self-immolative cleavage of quinone linkages and fluorogenic release of conjugated photosensitizers, leading to NIR fluorescence emission turn-on and activated PDT. Quinones 110-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-65 32093392-7 2020 The selected quinones were evaluated regarding their effects on cancer cell proliferation (clonogenic assay) and on Hsp90 and poly(ADPribose)polymerase (PARP) protein integrity. Quinones 13-21 heat shock protein 90 alpha family class A member 1 Homo sapiens 116-121 31748224-14 2020 Carbene and quinone metabolites were both involved in the observed CYP3A inactivation by PPR. Quinones 12-19 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 67-72 31791861-7 2020 Mechanism involved phenolic homologues degradation using vacuum-ultraviolet (VUV) was summarized, where it underwent the formation of quinone structures, ring opening, short-chain organic acid, even eventually the transformation into NO3- and Cl- of PNP and OCP. Quinones 134-141 NBL1, DAN family BMP antagonist Homo sapiens 234-237 31568946-6 2020 Moreover, the treatment with Cu(II) and quinones increased the activities and the expression of genes involved in the redox response, SOD1 and GPX, suggesting that PM components induced cellular damage due to redox imbalances. Quinones 40-48 superoxide dismutase 1 Homo sapiens 134-138 31748224-8 2020 An ortho-quinone intermediate was trapped by NAC in microsomal incubations with PPR. Quinones 3-16 synuclein alpha Homo sapiens 45-48 31993622-3 2020 Herein, quinone and ester-type oxygen-modified carbon has been successfully obtained by chemical activation with alkali, which is beneficial to the absorption of PF6- together with lithium ions, which would largely improve the electrode kinetics. Quinones 8-15 sperm associated antigen 17 Homo sapiens 162-165 32007910-9 2020 Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Quinones 128-136 NFE2 like bZIP transcription factor 2 Homo sapiens 25-29 31748224-10 2020 It appears that both carbene and ortho-quinone intermediates were involved in the inactivation of CYP3A caused by PPR. Quinones 33-46 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 98-103 32007910-9 2020 Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Quinones 128-136 kelch like ECH associated protein 1 Homo sapiens 30-35 32007910-9 2020 Our results suggest that NRF2/KEAP1 mutational status might serve as a predictive biomarker for response to NQO1-bioactivatable quinones in patients. Quinones 128-136 NAD(P)H quinone dehydrogenase 1 Homo sapiens 108-112 31017233-9 2020 Preliminary phytochemical screening showed that the Sc-Hex and the Sc-CHCl3 were positive for the presence of flavonoids, anthracene derivatives, quinones, triterpenes and steroids. Quinones 146-154 hematopoietically expressed homeobox Mus musculus 55-58 31790652-0 2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. Quinones 178-185 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 130-139 31790652-0 2020 Dopamine attenuates lipopolysaccharide-induced expression of proinflammatory cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglia. Quinones 178-185 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 140-143 31790652-10 2020 These results suggest that dopamine attenuated LPS-induced expression of cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglial cells. Quinones 174-181 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 126-135 31790652-10 2020 These results suggest that dopamine attenuated LPS-induced expression of cytokines by inhibiting the nuclear translocation of NF-kappaB p65 through the formation of dopamine quinone in microglial cells. Quinones 174-181 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 136-139 31608921-4 2019 Herein, based on a dye generated in situ strategy, a dual-enzyme-responsive probe, CNN, was rationally designed and synthesized by installing p-nitrobenzene and trimethyl-locked quinone propionic acid groups, which are specific for NTR and hNQO1, respectively, into a single fluorophore. Quinones 178-200 NAD(P)H quinone dehydrogenase 1 Homo sapiens 240-245 32271705-4 2020 The conversion of the phenols by tyrosinase to quinones is the rate-limiting step in the biochemical manufacture of melanin. Quinones 47-55 tyrosinase Homo sapiens 33-43 31590044-4 2020 We therefore hypothesized that Sec residues should be readily modified by quinones and with potential consequences for the structure and function of selenoproteins. Quinones 74-82 eukaryotic elongation factor, selenocysteine-tRNA-specific Mus musculus 31-34 31585271-7 2019 The UV-visible spectra showed compound 22 inhibits the formation of dopamine quinone, further the molecular docking analysis of compound 22 with tyrosinase (PDB: 2Y9X) indicated that compound 22 interacted with the amino acid residues of tyrosinase. Quinones 77-84 tyrosinase Mus musculus 145-155 31585271-7 2019 The UV-visible spectra showed compound 22 inhibits the formation of dopamine quinone, further the molecular docking analysis of compound 22 with tyrosinase (PDB: 2Y9X) indicated that compound 22 interacted with the amino acid residues of tyrosinase. Quinones 77-84 tyrosinase Mus musculus 238-248 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. Quinones 63-70 thioredoxin Homo sapiens 130-143 31926625-3 2020 In the studies reported here, the interactions of a prototypic quinone compound, p-benzoquinone (BQ), with the key redox protein, thioredoxin-1 (Trx1) were examined. Quinones 63-70 thioredoxin Homo sapiens 145-149 31470169-3 2019 Four of the unknown quinones (umbellatas A, H, K and M) showed potent cytotoxic effects against A431, A2780, NCI-H460, HCT116, HepG2, and MCF-7 human cancer cell lines with IC50 values of 1.3-7.1 muM. Quinones 20-28 latexin Homo sapiens 196-199 31731682-1 2019 Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. Quinones 22-35 complement C3 Homo sapiens 155-158 31731682-1 2019 Twenty-seven L-shaped ortho-quinone analogs were designed and synthesized using a one pot double-radical synthetic strategy followed by removing methyl at C-3 of the furan ring and introducing a diverse side chain at C-2 of the furan ring. Quinones 22-35 complement C2 Homo sapiens 217-220 31731682-8 2019 The structure-activity relationships evaluation showed that removing methyl at C-3 of the furan ring and introducing diverse side chains at C-2 of the furan ring is an effective strategy for improving the anticancer activity of L-shaped ortho-quinone analogs. Quinones 237-250 complement C3 Homo sapiens 79-82 31731682-8 2019 The structure-activity relationships evaluation showed that removing methyl at C-3 of the furan ring and introducing diverse side chains at C-2 of the furan ring is an effective strategy for improving the anticancer activity of L-shaped ortho-quinone analogs. Quinones 237-250 complement C2 Homo sapiens 140-143 31589435-3 2019 We demonstrate that the chemical modification of protein with QPN, a ligand that could be reduced by tumor cell-specific NAD(P)H dehydrogenase [quinone] 1 (NQO1), is reversible in the presence of NQO1. Quinones 144-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-160 31589435-3 2019 We demonstrate that the chemical modification of protein with QPN, a ligand that could be reduced by tumor cell-specific NAD(P)H dehydrogenase [quinone] 1 (NQO1), is reversible in the presence of NQO1. Quinones 144-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 196-200 31357365-13 2019 Quinones were found at concentrations ranging from below the LOD to up to 19.8 mug L-1. Quinones 0-8 immunoglobulin kappa variable 1-16 Homo sapiens 83-86 31480790-0 2019 Cancer Cell Sensitivity to Redox-Cycling Quinones is Influenced by NAD(P)H: Quinone Oxidoreductase 1 Polymorphism. Quinones 41-49 NAD(P)H quinone dehydrogenase 1 Homo sapiens 67-100 31357365-7 2019 For quinones, it varied from 1.12 mug L-1 (1,4-naphthoquinone) to 1.70 mug L-1(9,10-phenanthrenequinone). Quinones 4-12 immunoglobulin kappa variable 1-16 Homo sapiens 38-41 31357365-7 2019 For quinones, it varied from 1.12 mug L-1 (1,4-naphthoquinone) to 1.70 mug L-1(9,10-phenanthrenequinone). Quinones 4-12 immunoglobulin kappa variable 1-16 Homo sapiens 75-78 31781156-7 2019 Similarly, we found lineage-specific duplications in genes encoding complex I subunits that interact with quinones (NDUF2 and NDUF7). Quinones 106-114 Complex I-49kD Caenorhabditis elegans 116-121 31781156-7 2019 Similarly, we found lineage-specific duplications in genes encoding complex I subunits that interact with quinones (NDUF2 and NDUF7). Quinones 106-114 putative NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial Caenorhabditis elegans 126-131 31533349-7 2019 Inhibitor of NQO1, dicoumarol, and inhibitors of cytochromes P-450 alpha-naphthoflavone, isoniazid and miconazole statistically significantly (p < 0.02) decreased the toxicity of ArN O, and potentiated the cytotoxicity of quinones. Quinones 222-230 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-17 31460159-3 2019 Following our previous investigation of quinones as HER2 kinase inhibitors, we synthesized several naphthoquinone derivatives that significantly inhibited breast tumor cells expressing HER2 and trastuzumab-resistant HER2 oncogenic isoform, HER2Delta16. Quinones 40-48 erb-b2 receptor tyrosine kinase 2 Homo sapiens 52-56 31158658-7 2019 Furthermore, quinones are likely to be the functional groups that shuttle electrons during PCB dechlorination. Quinones 13-21 pyruvate carboxylase Homo sapiens 91-94 32055310-5 2019 This strategy is demonstrated using a PA probe designed for a tumor biomarker, human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1), which affords high contrast and excellent sensitivity for PA detection and imaging of hNQO1 in living cells and animals. Quinones 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 128-133 32055310-5 2019 This strategy is demonstrated using a PA probe designed for a tumor biomarker, human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1), which affords high contrast and excellent sensitivity for PA detection and imaging of hNQO1 in living cells and animals. Quinones 94-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 222-227 32055299-5 2019 In this review, IDO1 inhibitors are grouped as tryptophan derivatives, inhibitors with an imidazole, 1,2,3-triazole or tetrazole scaffold, inhibitors with quinone or iminoquinone, N-hydroxyamidines and other derivatives, and their enzymatic inhibitory activity, selectivity and other biological activities are also introduced and summarized. Quinones 155-162 indoleamine 2,3-dioxygenase 1 Homo sapiens 16-20 31460159-3 2019 Following our previous investigation of quinones as HER2 kinase inhibitors, we synthesized several naphthoquinone derivatives that significantly inhibited breast tumor cells expressing HER2 and trastuzumab-resistant HER2 oncogenic isoform, HER2Delta16. Quinones 40-48 erb-b2 receptor tyrosine kinase 2 Homo sapiens 185-189 31460159-3 2019 Following our previous investigation of quinones as HER2 kinase inhibitors, we synthesized several naphthoquinone derivatives that significantly inhibited breast tumor cells expressing HER2 and trastuzumab-resistant HER2 oncogenic isoform, HER2Delta16. Quinones 40-48 erb-b2 receptor tyrosine kinase 2 Homo sapiens 185-189 30504209-8 2019 These results indicate that LdhA-Dld serves as a bypass of NDH in electron transfer from NADH to quinones. Quinones 97-105 2-hydroxyacid dehydrogenase Shewanella oneidensis MR-1 28-32 31360690-1 2019 Background: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-44 31360690-1 2019 Background: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 31026584-4 2019 Multiple quinones were incubated with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), creatine kinase (CK), papain, bovine (BSA) and human (HSA) serum albumins, with the kinetics of adduction and effects on protein structure and activity determined. Quinones 9-17 LOC786101 Bos taurus 38-78 31026584-4 2019 Multiple quinones were incubated with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), creatine kinase (CK), papain, bovine (BSA) and human (HSA) serum albumins, with the kinetics of adduction and effects on protein structure and activity determined. Quinones 9-17 LOC786101 Bos taurus 80-85 31026584-7 2019 Incubation of purified proteins, or cell lysates, with quinones resulted in a rapid loss of GAPDH and CK activity; this loss correlated well with the rate constant for Cys adduction. Quinones 55-63 LOC786101 Bos taurus 92-97 31026584-8 2019 Glutathione (GSH) reacts competitively with quinones, and could reverse the loss of activity and dimerization of GAPDH and CK. Quinones 44-52 LOC786101 Bos taurus 113-118 30504209-8 2019 These results indicate that LdhA-Dld serves as a bypass of NDH in electron transfer from NADH to quinones. Quinones 97-105 NAD(P)/FAD-dependent oxidoreductase Shewanella oneidensis MR-1 59-62 30504209-11 2019 Here, we show that LdhA (an NADH-dependent d-LDH) works in concert with Dld (a quinone-dependent d-LDH) to transfer electrons from NADH to quinones during sugar catabolism in S. oneidensis MR-1. Quinones 139-147 2-hydroxyacid dehydrogenase Shewanella oneidensis MR-1 19-23 30525559-3 2019 A laser ablation process enables integration of quinones into the BDD electrode surface with a high p Ka1 (first protonation state) and with controllable, very low surface coverages (as low as 2 orders of magnitude below monolayer coverage). Quinones 48-56 glutamate ionotropic receptor kainate type subunit 4 Homo sapiens 102-105 30518535-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 30518535-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) catalyses the two electron reduction of quinones and a wide range of other organic compounds. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 30222979-3 2018 Using recombinant human enzyme, we discovered that cytochrome b5 reductase mediates redox cycling of a variety of quinones generating superoxide anion, hydrogen peroxide, and, in the presence of transition metals, hydroxyl radicals. Quinones 114-122 cytochrome b5 type A Homo sapiens 51-64 31091472-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. Quinones 102-110 tumor protein p53 Homo sapiens 264-267 31267862-8 2019 The main emerging themes were as follows: phenolic compounds often showed potential to affect the production of thyroid hormones; sulfur-containing compounds impacted the pathogenesis of goiter and the proliferation of thyroid cancer cells; while quinones and terpenoids modified Nrf2 signaling in thyroid cell lines. Quinones 247-255 NFE2 like bZIP transcription factor 2 Homo sapiens 280-284 31091472-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 31091472-1 2019 NAD(P)H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic detoxification and redox balance, and also has roles in stabilising apoptosis regulators such as p53. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 30463673-7 2018 The kinetics and amplitudes of these resolved kinetic phases in liquid and trehalose-embedded PS I samples could be well-fitted by a kinetic model that allowed us to calculate the asymmetrical contribution of the A1A- and A1B- quinones to the electrochromic signal at 480 nm. Quinones 227-235 alpha-1-B glycoprotein Homo sapiens 222-225 30222979-9 2018 This activity, together with the inhibition of cytochrome b5 reduction by redox-active chemicals and consequent deficiencies in available cellular cytochrome b5, are likely to contribute to tissue injury following exposure to quinones and related redox active chemicals. Quinones 226-234 cytochrome b5 type A Homo sapiens 47-60 30222979-9 2018 This activity, together with the inhibition of cytochrome b5 reduction by redox-active chemicals and consequent deficiencies in available cellular cytochrome b5, are likely to contribute to tissue injury following exposure to quinones and related redox active chemicals. Quinones 226-234 cytochrome b5 type A Homo sapiens 147-160 29561160-0 2018 An Orchestrated Unsymmetrical Annulation Episode of C(sp2)-H Bonds with Alkynes and Quinones: Access to Spiro-isoquinolones. Quinones 84-92 Sp2 transcription factor Homo sapiens 52-57 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-32 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-39 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-32 30062552-2 2018 NAD(P)H:quinone oxidoreductase 1 (NQO-1), the enzyme responsible for biotransformation of quinones into hydroquinones, was examined for its involvement in these endothelium-dependent augmentations, establishing a link between the metabolism of quinones by NQO-1 and biased sGC activity. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-39 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 29712428-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase responsible for detoxification of quinones and also bioactivation of certain quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 29523543-3 2018 In a continuum from the photic zone through the chemocline into deep anoxic sediments of the southern Black Sea, diagnostic quinones and inorganic geochemical parameters indicate niche segregation between redox processes and corresponding shifts in microbial community composition. Quinones 124-132 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 108-111 30062552-7 2018 In coronary arteries, repeated acute hypoxia caused similar augmentations as those to quinones that were inhibited by the NQO-1 inhibitor dicoumarol. Quinones 86-94 NAD(P)H quinone dehydrogenase 1 Sus scrofa 122-127 30062552-8 2018 Augmentations of contraction observed with different naturally occurring quinones and with acute hypoxia are initiated by quinone metabolism by NQO-1, in turn interfering with the NO/biased sGC pathway, suggesting a possibly detrimental role of this enzyme in ischemic cardiovascular disorders. Quinones 73-81 NAD(P)H quinone dehydrogenase 1 Sus scrofa 144-149 30222738-8 2018 We conclude that Alb and Hb adducts of estrogen quinones are promising biomarkers for the early detection of breast cancer. Quinones 48-56 albumin Homo sapiens 17-20 29934320-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 29934320-1 2018 NAD(P)H:quinone oxidoreductase 1 (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 29715013-2 2018 By using kinetics, fluorescence, and mass spectrometric analyses, PA1225 was shown to utilize FAD to transfer a hydride ion from NADPH to quinones. Quinones 138-146 NAD(P)H dehydrogenase Pseudomonas aeruginosa PAO1 66-72 29298345-1 2018 NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 29420036-9 2018 The results indicate similar but somewhat different locations/binding sites of quinones between hRC and PS I. Quinones 79-87 histidine rich calcium binding protein Homo sapiens 96-99 29345904-2 2018 Specifically, the strategy was illustrated by using a model quinones-generating oxidase of tyrosinase (Tyr) to catalytically produce 1,2-bezoquinone or its derivative, which can easily and selectively be conjugated onto the surface of the chitosan deposited PbS/NiO/FTO photocathode via the QCCC. Quinones 60-68 tyrosinase Homo sapiens 91-101 29345904-2 2018 Specifically, the strategy was illustrated by using a model quinones-generating oxidase of tyrosinase (Tyr) to catalytically produce 1,2-bezoquinone or its derivative, which can easily and selectively be conjugated onto the surface of the chitosan deposited PbS/NiO/FTO photocathode via the QCCC. Quinones 60-68 tyrosinase Homo sapiens 103-106 29345904-2 2018 Specifically, the strategy was illustrated by using a model quinones-generating oxidase of tyrosinase (Tyr) to catalytically produce 1,2-bezoquinone or its derivative, which can easily and selectively be conjugated onto the surface of the chitosan deposited PbS/NiO/FTO photocathode via the QCCC. Quinones 60-68 FTO alpha-ketoglutarate dependent dioxygenase Homo sapiens 266-269 28643389-1 2018 A combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), and molecular modelling methods were used to understand the potent inhibitory NAD(P)H:quinone oxidoreductase 1 (NQO1) activity of a set of 52 heterocyclic quinones. Quinones 246-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 169-201 28643389-2 2018 Molecular docking results indicated that some favourable interactions of key amino acid residues at the binding site of NQO1 with these quinones would be responsible for an improvement of the NQO1 activity of these compounds. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 192-196 28643389-1 2018 A combination of three-dimensional quantitative structure-activity relationship (3D-QSAR), and molecular modelling methods were used to understand the potent inhibitory NAD(P)H:quinone oxidoreductase 1 (NQO1) activity of a set of 52 heterocyclic quinones. Quinones 246-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 203-207 28643389-2 2018 Molecular docking results indicated that some favourable interactions of key amino acid residues at the binding site of NQO1 with these quinones would be responsible for an improvement of the NQO1 activity of these compounds. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 120-124 28164770-5 2018 NQO1 is a cytosolic homodimeric flavoprotein that catalyses the two-electron reduction of quinones and related molecules aimed at increasing their solubility and excretion. Quinones 90-98 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 29031799-7 2017 The relative enhancement in the presence of HA in the photodegradation of PFOS can be attributed to several factors: a) HA enhances the effective generation of eaq- due to the reduction of I2, HOI, IO3- and I3- back to I-; b) certain functional groups of HA (i.e., quinones) enhance the electron transfer efficiency as electron shuttles; c) a weakly-bonded association of I- and PFOS with HA increases the reaction probability; and d) absorption of UV photons by HA itself produces eaq-. Quinones 265-273 brain protein I3 Homo sapiens 198-209 28883796-4 2017 Established roles of NQO1 include its ability to prevent certain quinones from one electron redox cycling but its role in quinone detoxification is dependent on the redox stability of the hydroquinone generated by two-electron reduction. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-25 28831654-1 2017 Quinones serve as redox active cofactors in bacterial photosynthetic reaction centers: photosystem I, photosystem II, cytochrome bc 1, and cytochrome b 6 f. In particular, ubiquinone is ubiquitous in animals and most bacteria and plays a key role in several cellular processes, e.g., mitochondrial electron transport. Quinones 0-8 mitochondrially encoded cytochrome b Homo sapiens 118-130 28595002-4 2017 Using recombinant human enzyme, we discovered that DCXR mediates redox cycling of a variety of quinones generating superoxide anion, hydrogen peroxide, and, in the presence of transition metals, hydroxyl radicals. Quinones 95-103 dicarbonyl and L-xylulose reductase Homo sapiens 51-55 28317771-4 2017 The intermediate structures delivered from the reaction of ortho-quinones with alpha-amino acids were demonstrated by MSn. Quinones 65-73 moesin Homo sapiens 118-121 28499769-9 2017 On the other hand, Pst2p efficiently catalyzes the NAD(P)H dependent two-electron reduction of natural and artificial quinones. Quinones 118-126 flavodoxin-like fold family protein Saccharomyces cerevisiae S288C 19-24 28645578-6 2017 As shown, Fe3+ enhanced hydroquinone-induced Nrf2 activation and ARE-driven gene expressions, suggesting quinones rather than hydroquinone activate Nrf2 through Bach1 arylation. Quinones 105-113 NFE2 like bZIP transcription factor 2 Homo sapiens 45-49 28645578-6 2017 As shown, Fe3+ enhanced hydroquinone-induced Nrf2 activation and ARE-driven gene expressions, suggesting quinones rather than hydroquinone activate Nrf2 through Bach1 arylation. Quinones 105-113 NFE2 like bZIP transcription factor 2 Homo sapiens 148-152 28645578-0 2017 The electrophilic character of quinones is essential for the suppression of Bach1. Quinones 31-39 BTB domain and CNC homolog 1 Homo sapiens 76-81 28645578-6 2017 As shown, Fe3+ enhanced hydroquinone-induced Nrf2 activation and ARE-driven gene expressions, suggesting quinones rather than hydroquinone activate Nrf2 through Bach1 arylation. Quinones 105-113 BTB domain and CNC homolog 1 Homo sapiens 161-166 28645578-3 2017 In the current study, we found that quinones show greater capacity than hydroquinones in nuclear Bach1 export, as well as ubiquitin-dependent Bach1 degradation in our experimental time frame. Quinones 36-44 BTB domain and CNC homolog 1 Homo sapiens 97-102 28645578-7 2017 Taking together, our investigation illustrated that the electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling. Quinones 83-91 BTB domain and CNC homolog 1 Homo sapiens 122-127 28645578-4 2017 Consistently, quinones are easier than hydroquinones in Nrf2 activation and ARE-driven antioxidant protein expressions. Quinones 14-22 NFE2 like bZIP transcription factor 2 Homo sapiens 56-60 28645578-7 2017 Taking together, our investigation illustrated that the electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling. Quinones 83-91 BTB domain and CNC homolog 1 Homo sapiens 174-179 28645578-7 2017 Taking together, our investigation illustrated that the electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling. Quinones 83-91 NFE2 like bZIP transcription factor 2 Homo sapiens 204-208 27986568-0 2017 Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1. Quinones 86-94 NAD(P)H quinone dehydrogenase 1 Homo sapiens 105-109 28578385-1 2017 NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 28578385-1 2017 NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 148-152 28319393-1 2017 Abenquines are natural quinones, produced by some Streptomycetes, showing the ability to inhibit cyanobacterial growth in the 1 to 100 muM range. Quinones 23-31 latexin Homo sapiens 135-138 27768525-4 2017 Significant change of redox status, loss of mitochondrial membrane potentials ( Psi) and increase of superoxide dismutase (SOD) activity were induced by exposure to quinones. Quinones 165-173 superoxide dismutase 1 Homo sapiens 101-121 28639725-1 2017 NAD(P)H: Quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species. Quinones 117-125 crystallin zeta Homo sapiens 9-31 28639725-1 2017 NAD(P)H: Quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species. Quinones 117-125 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 32264042-1 2017 DT-diaphorase, which catalyzes the reduction of various biological substances like quinones, is overexpressed in some malignant tumors. Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 27768525-4 2017 Significant change of redox status, loss of mitochondrial membrane potentials ( Psi) and increase of superoxide dismutase (SOD) activity were induced by exposure to quinones. Quinones 165-173 superoxide dismutase 1 Homo sapiens 123-126 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 glutathione S-transferase kappa 1 Homo sapiens 192-195 27913299-2 2017 NQO1 reduces quinones to hydroquinones using NADH as an electron donor and consequently increases the intracellular NAD+/NADH ratio. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 233-237 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 198-230 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 kelch like ECH associated protein 1 Homo sapiens 240-275 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 kelch like ECH associated protein 1 Homo sapiens 277-282 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 aryl hydrocarbon receptor Homo sapiens 311-335 27617882-9 2017 This perspective explores the varied biological targets of quinones including GSH, NADPH, protein sulfhydryls [heat shock proteins, P450s, cyclooxygenase-2 (COX-2), glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1, (NQO1), kelch-like ECH-associated protein 1 (Keap1), IkappaB kinase (IKK), and arylhydrocarbon receptor (AhR)], and DNA. Quinones 59-67 aryl hydrocarbon receptor Homo sapiens 337-340 29374432-3 2017 Of these, only tyrosinase has two activities: (1) oxygenase activity to hydroxylate monophenols to ortho-diphenols and (2) oxidase activity responsible for further oxidation of ortho-diphenols to ortho-quinones. Quinones 202-210 tyrosinase Homo sapiens 15-25 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 6-38 27558805-1 2016 NQO1 (NAD(P)H-quinone oxidoreductase 1) reduces quinones and xenobiotics to less-reactive compounds via 2-electron reduction, one feature responsible for the role of NQO1 in antioxidant defense in several tissues. Quinones 48-56 NAD(P)H quinone dehydrogenase 1 Homo sapiens 166-170 27558805-2 2016 In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation. Quinones 100-108 cytochrome p450 oxidoreductase Homo sapiens 19-49 27558805-2 2016 In contrast, NADPH cytochrome P450 oxidoreductase (CYP450OR), catalyzes the 1-electron reduction of quinones and xenobiotics, resulting in enhanced superoxide formation. Quinones 100-108 cytochrome p450 oxidoreductase Homo sapiens 51-59 27790277-4 2016 NADH:quinone oxidoreductase 1 (NQO1) is a homodimeric enzyme that catalyzes the oxidation of NADH to NAD+ by various quinones and thereby elevates the intracellular NAD+ levels. Quinones 117-125 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-29 27790277-4 2016 NADH:quinone oxidoreductase 1 (NQO1) is a homodimeric enzyme that catalyzes the oxidation of NADH to NAD+ by various quinones and thereby elevates the intracellular NAD+ levels. Quinones 117-125 NAD(P)H dehydrogenase, quinone 1 Mus musculus 31-35 27656164-4 2016 Three different quinones, i.e., ubiquinone, demethyl-menaquinone and menaquinone, couple the transfer of electrons between the dehydrogenases and reductases/oxidases that constitute this electron transfer chain, whereas, the two-component regulation system ArcB/A regulates gene expression, to allow the organism to adapt itself to the ambient conditions of available electron donors and acceptors. Quinones 16-24 hypothetical protein Escherichia coli 257-261 27251440-0 2016 Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k. Quinones 0-8 mechanistic target of rapamycin kinase Homo sapiens 127-131 27251440-0 2016 Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k. Quinones 0-8 ribosomal protein S6 kinase B1 Homo sapiens 132-138 27258437-0 2016 Prodrugs Bioactivated to Quinones Target NF-kappaB and Multiple Protein Networks: Identification of the Quinonome. Quinones 25-33 nuclear factor kappa B subunit 1 Homo sapiens 41-50 27048660-9 2016 Unlike other NQO1-dependent cytotoxic quinones, such as streptonigrin, menadione, mitomycin, and 17-allylamino-17-demethoxygeldanamycin, beta-lap was the only agent that could cause Hsp90 cleavage. Quinones 38-46 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-17 26856346-1 2016 The NADPH dehydrogenase quinone oxido-reductase 1 (NQO1) enzyme is an antioxidant and metabolic enzyme that performs two electron reduction of quinones and other chemicals. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-49 26856346-1 2016 The NADPH dehydrogenase quinone oxido-reductase 1 (NQO1) enzyme is an antioxidant and metabolic enzyme that performs two electron reduction of quinones and other chemicals. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 51-55 27173800-0 2016 Identification of quinones as novel PIM1 kinase inhibitors. Quinones 18-26 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 36-40 27362889-1 2016 Quinones and quinones-like compounds are potential candidates for the inhibition of CDC25 phosphatases. Quinones 0-8 cell division cycle 25C Homo sapiens 84-89 27109346-11 2016 The chloroplastic enzyme PPO catalyzes the oxidation of phenols to quinones, which react with protein. Quinones 67-75 protoporphyrinogen oxidase Bos taurus 25-28 27106784-0 2016 Electronic Structures and Chiroptical Properties of Post-functionalized Helicene Quinones. Quinones 81-89 solute carrier family 35 member G1 Homo sapiens 52-56 26958787-6 2016 As H2BQ can be extracted from biomass directly and its redox reaction mimics the bio-electrochemical process of quinones in nature, using such a bio-inspired organic compound in batteries enables access to greener and more sustainable energy-storage technology. Quinones 112-120 H2B clustered histone 21 Homo sapiens 3-7 26687450-0 2016 Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 52-56 26687450-0 2016 Overexpression of NAD(P)H:quinone oxidoreductase 1 (NQO1) and genomic gain of the NQO1 locus modulates breast cancer cell sensitivity to quinones. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 82-86 26687450-5 2016 Finally, the importance of NQO1 overexpression in the putative acquisition of either drug resistance or an increased sensitivity to quinones by cancer cells was investigated by immunoblotting and cytotoxicity assays. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 27-31 26721407-1 2016 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 26721407-1 2016 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety of quinones. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 27362889-1 2016 Quinones and quinones-like compounds are potential candidates for the inhibition of CDC25 phosphatases. Quinones 13-21 cell division cycle 25C Homo sapiens 84-89 26444384-6 2015 NQO1 is a 2-electron reductase responsible for the detoxification of quinones. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 27853106-4 2016 Furthermore, immunofluorescence analysis confirmed that these quinones enhanced translocation of AhR to the nucleus. Quinones 62-70 aryl hydrocarbon receptor Homo sapiens 97-100 26862668-6 2016 Moreover, among 1395 cigarette smoke components, naphthoquinones including 9,10-phenaotrenquinone, quinones, benzenediols and alpha, beta-unsaturated carbonyls, were identified as major smoke components that contribute to activating the NRF2/ARE pathway, as indicated by the ARE-reporter assay in BEAS-2B cells. Quinones 56-64 NFE2 like bZIP transcription factor 2 Homo sapiens 237-241 26558468-0 2015 Covalent binding of quinones activates the Ah receptor in Hepa1c1c7 cells. Quinones 20-28 aryl-hydrocarbon receptor Mus musculus 43-54 26558468-4 2015 To clarify the AhR response to mono- and bi-aromatic hydrocarbon quinones, we studied Cyp1a1 (cytochrome P450 1A1) induction and AhR activation by these quinones. Quinones 65-73 aryl-hydrocarbon receptor Mus musculus 15-18 26558468-5 2015 We detected Cyp1a1 induction during treatment with quinones in Hepa1c1c7 cells, but not their parent compounds. Quinones 51-59 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 12-18 26558468-6 2015 Nine of the twelve quinones with covalent binding capability for proteins induced Cyp1a1. Quinones 19-27 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 82-88 26558468-11 2015 Since we previously reported that 1,2-NQ and tert-butyl-1,4-BQ also activate NF-E2-related factor 2, it seems likely that some of quinones are bi-functional inducers for phase-I and phase-II reaction of xenobiotics. Quinones 130-138 nuclear factor, erythroid derived 2, like 2 Mus musculus 77-99 26424559-2 2015 The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. Quinones 45-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 26424559-2 2015 The NQO1- mediated two-electron reduction of quinones can be either chemoprotection/detoxification or a chemotherapeutic response, depending on the target quinones. Quinones 155-163 NAD(P)H quinone dehydrogenase 1 Homo sapiens 4-8 26424559-3 2015 When toxic quinones are reduced by NQO1, they are conjugated with glutathione or glucuronic acid and excreted from the cells. Quinones 11-19 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 26257249-1 2015 PURPOSE: NAD(P)H dehydrogenase, encoded by NAD(P)H quinone oxidoreductase 1 (NQO1), is an enzyme that catalyzes the reduction of quinones, including vitamin K. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-75 26257249-1 2015 PURPOSE: NAD(P)H dehydrogenase, encoded by NAD(P)H quinone oxidoreductase 1 (NQO1), is an enzyme that catalyzes the reduction of quinones, including vitamin K. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 25713930-2 2015 To explore the mechanism underlying that effect, we previously showed that oxidation of RD with mushroom tyrosinase produces RD-quinone, which is converted to secondary quinone products, and we suggested that those quinones are cytotoxic because they bind to cellular proteins and produce reactive oxygen species. Quinones 215-223 tyrosinase Homo sapiens 105-115 26046816-1 2015 In this study, the influence of two quinones (1,2- and 1,4-benzoquinone) on the operation and mechanism of electron transfer in PQQ-dependent glucose dehydrogenase (PQQ-sGDH) anodes has been determined. Quinones 36-44 NADH:ubiquinone oxidoreductase subunit B5 Homo sapiens 169-173 25903194-2 2015 A method able to detect and quantify PM oxidative potential, based on the cytochrome c (cyt-c) reduction by means of superoxide anion produced through quinones redox cycling in the presence of reducing agents, is here described. Quinones 151-159 cytochrome c, somatic Homo sapiens 74-86 25903194-2 2015 A method able to detect and quantify PM oxidative potential, based on the cytochrome c (cyt-c) reduction by means of superoxide anion produced through quinones redox cycling in the presence of reducing agents, is here described. Quinones 151-159 cytochrome c, somatic Homo sapiens 88-93 25994234-2 2015 It has been hypothesized that CPs are cross-linked to other CPs and possibly to chitin by quinones or quinone methides produced by the laccase2-mediated oxidation of N-acylcatechols. Quinones 90-98 laccase 2 Tribolium castaneum 135-143 25885439-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones and its derivatives. Quinones 130-138 crystallin zeta Homo sapiens 22-44 25885439-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones and its derivatives. Quinones 130-138 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 26415702-2 2015 CBR1 catalyzes the reduction of many xenobiotics, including important drugs (e.g. anthracyclines, nabumetone, bupropion, dolasetron) and harmful carbonyls and quinones. Quinones 159-167 carbonyl reductase 1 Homo sapiens 0-4 25602258-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), an obligate two-electron reductase, plays an important role in reducing reactive quinones to less reactive and less toxic hydroquinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 13-46 25677663-5 2015 Cytotoxicity studies and determination of superoxide (O2(-)) production in the presence and absence of the NOQ1 inhibitor dicoumarol confirmed that the ortho-quinones exerted their antitumor activity through NQO1-mediated ROS production by redox cycling. Quinones 158-166 NAD(P)H quinone dehydrogenase 1 Homo sapiens 208-212 25550200-2 2015 SPR also mediates chemical redox cycling, catalyzing one-electron reduction of redox-active chemicals, including quinones and bipyridinium herbicides (e.g., menadione, 9,10-phenanthrenequinone, and diquat); rapid reaction of the reduced radicals with molecular oxygen generates reactive oxygen species (ROS). Quinones 113-121 sepiapterin reductase Rattus norvegicus 0-3 25541907-1 2015 LTQ Orbitrap MS/MS was used to identify the adducts between quinones derived from rosmarinic acid (RosA) and thiol compounds, including cysteine (Cys), glutathione (GSH), and peptides digested from myosin. Quinones 60-68 myosin heavy chain 14 Homo sapiens 198-204 25602258-1 2015 BACKGROUND: NAD(P)H: quinone oxidoreductase 1 (NQO1), an obligate two-electron reductase, plays an important role in reducing reactive quinones to less reactive and less toxic hydroquinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 48-52 26666298-4 2015 Two quinones (1, 2) exhibited moderate cytotoxic activity against the human cancer cell lines (Hela, HepG2, and K562) with IC50 values of 11.24-35.15 muM in vitro. Quinones 4-12 latexin Homo sapiens 150-153 25747212-2 2015 In biological systems, quinones are reduced to semiquinone radicals by the enzyme NADPH:quinone reductase. Quinones 23-31 crystallin zeta Homo sapiens 82-105 26821466-5 2015 Tyrosinase-mediated oxidation of these chemicals yields toxic ortho-quinones which bind to cellular proteins and produce reactive oxygen species. Quinones 68-76 tyrosinase Homo sapiens 0-10 25260115-1 2014 The room-temperature oxidative C-H/C-H cross-couplings between (hetero)arenes and alkenes, coumarins or quinones have been reported by using a highly electrophilic palladium species [Pd(TFA)2], generated in situ from Pd(OAc)2 and TFA, as the catalyst and cheap (NH4)2S2O8 as the oxidant under air. Quinones 104-112 churchill domain containing 1 Homo sapiens 31-38 26584375-1 2014 The redox and proton transfer processes involving the several dimers arising from quinones are studied by quantum mechanical methods using second order perturbation theory (MP2) and a medium size basis set optimized for reproducing dispersion interactions. Quinones 82-90 tryptase pseudogene 1 Homo sapiens 173-176 25130058-7 2014 These results support the notion that the melanocyte toxicity of RD depends on its tyrosinase-catalyzed conversion to toxic quinones and the concomitant production of reactive oxygen species. Quinones 124-132 tyrosinase Homo sapiens 83-93 24830960-4 2014 NQO1 catalyzes the two-electron reduction of quinones to hydroquinones, thereby preventing the formation of ROS. Quinones 45-53 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 25232709-2 2014 Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione, methoxy-naphthoquinones, and others) to cellular and inter-cellular signaling processes are discussed: (i) naphthoquinone-induced Nrf2-dependent modulation of gene expression and its potentially beneficial outcome; (ii) the modulation of receptor tyrosine kinases, such as the epidermal growth factor receptor by naphthoquinones, resulting in altered gap junctional intercellular communication. Quinones 66-74 NFE2 like bZIP transcription factor 2 Homo sapiens 282-286 24608884-7 2014 The quinones do not generate significant levels of oxidative stress at concentrations that inhibit IDO. Quinones 4-12 indoleamine 2,3-dioxygenase 1 Homo sapiens 99-102 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 NFE2 like bZIP transcription factor 2 Homo sapiens 179-183 24552538-1 2014 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme capable of reducing a broad range of chemically reactive quinones and quinoneimines (QIs) and can be strongly upregulated by Nrf2/Keap1-mediated stress responses. Quinones 111-119 kelch like ECH associated protein 1 Homo sapiens 184-189 24374792-6 2014 The fact remains that the mutant Htt protein was seen to be associated with mitochondria directly, and as the striatum is highly enriched with dopamine and glutamate, it may make the striatal mitochondria more vulnerable because of the presence of dopa-quinones, and due to an imbalance in Ca(2+). Quinones 253-261 huntingtin Homo sapiens 33-36 24196959-6 2013 All except the quinones were potentiated by POR overexpression. Quinones 15-23 cytochrome p450 oxidoreductase Homo sapiens 44-47 24447297-4 2014 These studies, and comparative analyses of the kinetics with thio-NAD(+) and quinone electron acceptors, provided evidence that Mtb NDH-2 catalyzes the transfer electrons from NADH to quinone substrates by a nonclassical, two-site ping-pong kinetic mechanism whereby substrate quinones bind to a site that is distinct from the NADH-binding site. Quinones 277-285 DExH-box helicase 9 Homo sapiens 132-137 24355130-0 2014 Identification of quinones as HER2 inhibitors for the treatment of trastuzumab resistant breast cancer. Quinones 18-26 erb-b2 receptor tyrosine kinase 2 Homo sapiens 30-34 24083611-5 2014 According to their structural features, CYP1 inhibitors are divided into the following categories: flavonoids, trans-stilbenes, coumarins, terpenoids, alkaloids, quinones, isothiocyanates and synthetic aromatics. Quinones 162-170 cytochrome P450 family 27 subfamily B member 1 Homo sapiens 40-44 24074361-1 2013 NAD(P)H: quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinones 118-126 crystallin zeta Homo sapiens 9-31 24144187-3 2013 Herein, the interaction of Ngb with the quinones generated by oxidation of catecholamines (dopamine, norepinephrine) and catechol estrogens (2-hydroxyestradiol and 4-hydroxyestradiol), which have been implicated in neurodegenerative pathologies like Parkinson"s and Alzheimer"s diseases, has been investigated. Quinones 40-48 neuroglobin Homo sapiens 27-30 24074361-1 2013 NAD(P)H: quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 24074361-1 2013 NAD(P)H: quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinones 118-126 crystallin zeta Homo sapiens 47-69 24074361-1 2013 NAD(P)H: quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) catalyze the two-electron reduction of quinones and thereby prevent generation of toxic radicals. Quinones 118-126 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 73-77 24074361-3 2013 Based on similar structural features of quinones and QMs, it is logical to assume that NQO1 and/or NQO2 could also catalyze the two-electron reduction of QMs. Quinones 40-48 NAD(P)H quinone dehydrogenase 1 Homo sapiens 87-91 24074361-3 2013 Based on similar structural features of quinones and QMs, it is logical to assume that NQO1 and/or NQO2 could also catalyze the two-electron reduction of QMs. Quinones 40-48 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 99-103 24015818-1 2013 NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K. Quinones 144-152 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-4 24015818-1 2013 NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K. Quinones 144-152 NAD(P)H dehydrogenase, quinone 1 Mus musculus 6-38 24015818-1 2013 NQO1 [NAD(P)H quinone oxidoreductase 1; also known as DT-diaphorase] is a cytosolic enzyme that catalyses the two-electron reduction of various quinones including vitamin K. Quinones 144-152 NAD(P)H dehydrogenase, quinone 1 Mus musculus 54-67 24059442-9 2013 A decrease in substrate inhibition with DHEA was seen following preincubation of hSULT2A1 with all of the quinones. Quinones 106-114 sulfotransferase family 2A member 1 Homo sapiens 81-89 23994167-5 2013 In the NADPH-linked reduction, 3HBD showed broad substrate specificity for a variety of quinones, ketones and aldehydes, including 3-, 17- and 20-ketosteroids and prostaglandin D2, which were converted to 3alpha-, 17beta- and 20alpha-hydroxysteroids and 9alpha,11beta-prostaglandin F2, respectively. Quinones 88-96 prostaglandin-E(2) 9-reductase-like Oryctolagus cuniculus 31-35 24059442-3 2013 Quinones derived from the oxidative metabolism of PCBs (PCB-quinones) react with nucleophilic sites in proteins and also undergo redox cycling to generate reactive oxygen species. Quinones 0-8 pyruvate carboxylase Homo sapiens 50-53 24116043-3 2013 Among the cellular components that control the redox state of these cysteines of ArcB are the quinones from the cytoplasmic membrane of the cell, which function in "respiratory" electron transfer. Quinones 94-102 hypothetical protein Escherichia coli 81-85 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 79-87 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-20 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 123-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 16-20 23937670-4 2013 In normal cells NQO1 is inducibly expressed, and its major role is to detoxify quinones via bioreduction; however, certain quinones become more toxic after reduction by NQO1, and these compounds have potential as selective anticancer agents. Quinones 123-131 NAD(P)H quinone dehydrogenase 1 Homo sapiens 169-173 23937670-7 2013 Here, we directly compare these quinones as substrates for NQO1 in vitro, and for their ability to kill cancer cells in culture in an NQO1-dependent manner. Quinones 32-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-63 23937670-7 2013 Here, we directly compare these quinones as substrates for NQO1 in vitro, and for their ability to kill cancer cells in culture in an NQO1-dependent manner. Quinones 32-40 NAD(P)H quinone dehydrogenase 1 Homo sapiens 134-138 24116043-5 2013 We report the relationship between growth, quinone content, ubiquinone redox state, the level of ArcA phosphorylation, and the level of ArcA-dependent gene expression, in a number of mutants of E. coli with specific alterations in their set of quinones, under a range of physiological conditions. Quinones 244-252 arginine deiminase Escherichia coli 136-140 23777273-3 2013 The resulting exo-dienes were then subjected to a second one-pot tandem process involving a highly regioselective Diels-Alder reaction with alkynes, quinones or nitriles and a subsequent oxidation step to give a diverse library of C-1 amino-substituted indanes and tetralins in good overall yields. Quinones 149-157 heterogeneous nuclear ribonucleoprotein C Homo sapiens 231-234 23759948-2 2013 However, the profound effects of TERE1 relate to its prenyltransferase activity for synthesis of the bioactive quinones menaquinone and COQ10. Quinones 111-119 UbiA prenyltransferase domain containing 1 Homo sapiens 33-38 23953689-2 2013 The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, which can lead to cell toxicity. Quinones 268-276 thioredoxin reductase 1 Homo sapiens 68-82 23953689-2 2013 The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, which can lead to cell toxicity. Quinones 268-276 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 90-109 23953689-2 2013 The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, which can lead to cell toxicity. Quinones 268-276 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 111-114 23640889-4 2013 In addition to reducing sepiapterin, SPR mediated chemical redox cycling of bipyridinium herbicides and various quinones; this activity was greatest for 1,2-naphthoquinone followed by 9,10-phenanthrenequinone, 1,4-naphthoquinone, menadione, and 2,3-dimethyl-1,4-naphthoquinone. Quinones 112-120 sepiapterin reductase Homo sapiens 37-40 23089469-2 2012 Quinone reductase 2 which can activate quinones leading to reactive oxygen species production is a melatonin receptor known as MT3. Quinones 39-47 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-19 23718265-5 2013 Treatment with redox cycling quinones activates PARP, and this stimulatory effect is attenuated in the presence of NO. Quinones 29-37 poly(ADP-ribose) polymerase 1 Homo sapiens 48-52 23635904-1 2013 A series of heterocyclic quinones based on benzofuran, benzothiophene, indazole and benzisoxazole has been synthesized, and evaluated for their ability to function as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumor cells. Quinones 25-33 NAD(P)H quinone dehydrogenase 1 Homo sapiens 232-236 23635904-2 2013 Overall, the quinones are excellent substrates for NQO1, approaching the reduction rates observed for menadione. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 51-55 23196068-3 2013 Synthesized dopamine can be neurotoxic through its enzymatic degradation by monoamine oxidase (MAO) to form the reactive byproduct, hydrogen peroxide and hydroxyl radicals or through auto-oxidation to form highly reactive quinones that can bind proteins and render them non-functional. Quinones 222-230 monoamine oxidase A Rattus norvegicus 76-93 23252650-4 2013 Similarly, the effective quenching of the AgNCs by quinones enabled the detection of tyrosinase through the biocatalyzed oxidation of tyrosine, dopamine, or tyramine to the respective quinone products. Quinones 51-59 tyrosinase Homo sapiens 85-95 23748219-1 2013 We examined the kinetics of single-electron reduction of a large number of structurally diverse quinones and nitroaromatic compounds, including a number of antitumour and antiparasitic drugs, and nitroaromatic explosives by recombinant rat neuronal nitric oxide synthase (nNOS, EC 1.14.13.39), aiming to characterize the role of nNOS in the oxidative stress-type cytotoxicity of the above compounds. Quinones 96-104 nitric oxide synthase 1 Rattus norvegicus 240-270 23748219-6 2013 On the other hand, at low oxygen concentrations ([O2] = 40-50 muM), nNOS performs a net two-electron reduction of quinones and nitroaromatics. Quinones 114-122 nitric oxide synthase 1 Rattus norvegicus 68-72 23064431-1 2013 Exploring the interaction between quinones and alpha-synuclein. Quinones 34-42 synuclein alpha Homo sapiens 47-62 23064431-2 2013 In the last decades, a series of compounds, including quinones and polyphenols, has been described as having anti-fibrillogenic action on alpha-synuclein (alpha-syn) whose aggregation is associated to the pathogenesis of Parkinson"s disease (PD). Quinones 54-62 synuclein alpha Homo sapiens 138-153 23064431-2 2013 In the last decades, a series of compounds, including quinones and polyphenols, has been described as having anti-fibrillogenic action on alpha-synuclein (alpha-syn) whose aggregation is associated to the pathogenesis of Parkinson"s disease (PD). Quinones 54-62 synuclein alpha Homo sapiens 138-147 23546588-7 2013 Inhibition of CYPs shifts NPR"s electron flow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity. Quinones 54-62 cytochrome p450 oxidoreductase Homo sapiens 26-29 23731014-0 2013 Inducers of hypoxic response: marine sesquiterpene quinones activate HIF-1. Quinones 51-59 hypoxia inducible factor 1 subunit alpha Homo sapiens 69-74 23583257-7 2013 Such model of Nox4 activity regulation could provide new insight into the understanding of the molecular mechanism of the electron transfer through the enzyme, i.e., its potential redox regulation, and could also define new therapeutic targets in diseases in which quinones and Nox4 are implicated. Quinones 265-273 NADPH oxidase 4 Homo sapiens 14-18 23563617-1 2013 A concise and efficient approach to arylquinones from widely available hydroquinones has been developed through a tandem reaction involving the oxidation of hydroquinones and subsequent oxidative C-H/C-H cross-coupling of the resulting quinones with arenes. Quinones 40-48 churchill domain containing 1 Homo sapiens 196-203 23329127-1 2013 The flavocytochrome cellobiose dehydrogenase (CDH) is a versatile biorecognition element capable of detecting carbohydrates as well as quinones and catecholamines. Quinones 135-143 choline dehydrogenase Homo sapiens 20-44 23329127-1 2013 The flavocytochrome cellobiose dehydrogenase (CDH) is a versatile biorecognition element capable of detecting carbohydrates as well as quinones and catecholamines. Quinones 135-143 choline dehydrogenase Homo sapiens 46-49 23196068-3 2013 Synthesized dopamine can be neurotoxic through its enzymatic degradation by monoamine oxidase (MAO) to form the reactive byproduct, hydrogen peroxide and hydroxyl radicals or through auto-oxidation to form highly reactive quinones that can bind proteins and render them non-functional. Quinones 222-230 monoamine oxidase A Rattus norvegicus 95-98 23064431-7 2013 Bidimensional NMR experiments indicate that a specific site at the N-terminal alpha-syn (Gly31/Lys32) is involved in the interaction with vitamins K, which is corroborated by previous studies suggesting that Lys is a key residue in the interaction with quinones. Quinones 253-261 synuclein alpha Homo sapiens 78-87 23141909-3 2012 Dimerisation of heterocyclic quinones has led to IRC-083864, a bis-quinone compound with increased CDC25B inhibitory activity. Quinones 29-37 cell division cycle 25B Homo sapiens 99-105 23089469-2 2012 Quinone reductase 2 which can activate quinones leading to reactive oxygen species production is a melatonin receptor known as MT3. Quinones 39-47 metallothionein 3 Homo sapiens 127-130 23734165-3 2012 O-Methylation by catechol-O-methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. Quinones 112-120 catechol-O-methyltransferase Homo sapiens 17-45 22687461-6 2012 Further investigation revealed that there was an upregulation of NAD(P)H: quinone oxidoreductase 1 (NQO1), a detoxification enzyme for benzene-derived quinones, in W7.2 rfau cells. Quinones 151-159 NAD(P)H quinone dehydrogenase 1 Homo sapiens 65-98 22687461-6 2012 Further investigation revealed that there was an upregulation of NAD(P)H: quinone oxidoreductase 1 (NQO1), a detoxification enzyme for benzene-derived quinones, in W7.2 rfau cells. Quinones 151-159 NAD(P)H quinone dehydrogenase 1 Homo sapiens 100-104 22793692-1 2012 NAD(P)H:quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that catalyzes the reduction of various quinones using flavin adenine dinucleotide (FAD) as a cofactor. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 22793692-1 2012 NAD(P)H:quinone-oxidoreductase-1 (NQO1) is a cytosolic enzyme that catalyzes the reduction of various quinones using flavin adenine dinucleotide (FAD) as a cofactor. Quinones 102-110 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 22736108-2 2012 NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. Quinones 137-145 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 22736108-2 2012 NADPH:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are phase II cytosolic enzymes that catalyze metabolism of quinones, important in the detoxification of environmental carcinogens. Quinones 137-145 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 72-76 21947872-1 2012 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of various quinones by utilizing NAD(P)H as an electron donor. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-33 21947872-1 2012 NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of various quinones by utilizing NAD(P)H as an electron donor. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 23734165-3 2012 O-Methylation by catechol-O-methyltransferase (COMT) blocks their estrogenicity and prevents their oxidation to quinones. Quinones 112-120 catechol-O-methyltransferase Homo sapiens 47-51 22586705-1 2012 Human NAD(P)H: quinone oxidoreductase 1 (NQO1) catalyzes the obligatory two-electron reduction of quinones. Quinones 98-106 NAD(P)H quinone dehydrogenase 1 Homo sapiens 6-39 22431735-0 2012 Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. Quinones 17-25 Parkinsonism associated deglycase Homo sapiens 67-71 22586705-1 2012 Human NAD(P)H: quinone oxidoreductase 1 (NQO1) catalyzes the obligatory two-electron reduction of quinones. Quinones 98-106 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-45 22209713-9 2012 Despite a large volume of preclinical data demonstrating that NQO1 is an important determinant of sensitivity to these antitumor quinones there is little information on whether the clinical response to these agents is influenced by the NQO1*2 polymorphism. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-66 23167798-8 2012 As observed with other redox cycling quinones, the protein cleavage is blocked in the presence of N-terminal Hsp90 inhibitors suggesting that the availability or occupancy of nucleotide binding site in the N-terminal pocket of Hsp90 plays a critical role. Quinones 37-45 heat shock protein 90 alpha family class A member 1 Homo sapiens 109-114 22209713-0 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 22209713-0 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 22209713-3 2012 The two-electron reduction of quinones by NQO1 has been shown to be an efficient pathway to hydroquinone formation. Quinones 30-38 NAD(P)H quinone dehydrogenase 1 Homo sapiens 42-46 22209713-6 2012 Individuals homozygous for the NQO1*2 allele are NQO1 null and homozygous NQO1*2*2 cell lines have been shown to be more resistant to antitumor quinones when compared to isogenic cell lines overexpressing NQO1. Quinones 144-152 NAD(P)H quinone dehydrogenase 1 Homo sapiens 31-35 22250969-3 2012 We investigated ET reactions between zinc-substituted cytochrome P450(cam) and small organic compounds such as quinones and ferrocene, which are capable of accessing the protein"s hydrophobic channel and binding close to the active site, like its native substrate, camphor. Quinones 111-119 calmodulin 3 Homo sapiens 54-74 23167798-8 2012 As observed with other redox cycling quinones, the protein cleavage is blocked in the presence of N-terminal Hsp90 inhibitors suggesting that the availability or occupancy of nucleotide binding site in the N-terminal pocket of Hsp90 plays a critical role. Quinones 37-45 heat shock protein 90 alpha family class A member 1 Homo sapiens 227-232 22984577-1 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. Quinones 139-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 22984577-1 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. Quinones 139-147 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 22029277-2 2011 Autocatalysis in the parent system is particularly efficient and leads to rapid, quantitative synthesis of quinones such as 4 from boronic acid 1 at room temperature using air as stoichiometric oxidant. Quinones 107-115 mediator complex subunit 25 Homo sapiens 139-145 22984577-2 2012 The 2-electron reduction of quinones to hydroquinones by NQO1 is believed to be a detoxification process since this reaction bypasses the formation of the highly reactive semiquinone. Quinones 28-36 NAD(P)H quinone dehydrogenase 1 Homo sapiens 57-61 22037513-0 2011 Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones. Quinones 54-62 NFE2 like bZIP transcription factor 2 Homo sapiens 21-25 21458432-12 2011 Although, as controls, 4-hydroxyanisole and L-tyrosine were metabolized by tyrosinase to form quinones and glutathione conjugates, they exhibited no GST inhibition in the absence and presence of tyrosinase. Quinones 94-102 tyrosinase Homo sapiens 75-85 21843634-1 2011 NAD(P)H:quinone oxidoreductase (NQO1)-mediated detoxification of quinones plays a critical role in cancer prevention. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 21733125-1 2011 NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 21733125-1 2011 NAD(P)H: quinone oxidoreductase1 (NQO1) is an important detoxification enzyme that can protect mammalian cells against toxic quinones and reduce the risk of tumorigenesis. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 21762045-1 2011 NRH:quinone oxidoreductase 2 (QR2) is a cytosolic enzyme that catalyzes the reduction of quinones, such as menadione and co-enzymes Q. Quinones 89-97 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-28 21762045-1 2011 NRH:quinone oxidoreductase 2 (QR2) is a cytosolic enzyme that catalyzes the reduction of quinones, such as menadione and co-enzymes Q. Quinones 89-97 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 30-33 21714592-5 2011 The classification in this review includes COX-2 inhibitors based on five- and six-membered heterocycles, benzoheterocycles (e.g., benzopyrans, benzopyranones, indoles and quinolines), quinones, chalcones, natural products and miscellaneous. Quinones 185-193 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 21664341-3 2011 To gain further insights into the mechanism of AIF, we investigated its interaction with a series of quinone oxidants, including a number of anticancer quinones. Quinones 152-160 apoptosis inducing factor mitochondria associated 1 Homo sapiens 47-50 21664341-8 2011 However, high-potential quinones, e.g. a toxic natural compound naphthazarin, maintain AIF in the oxidized state when a significant excess of NADH is present. Quinones 24-32 apoptosis inducing factor mitochondria associated 1 Homo sapiens 87-90 20970411-2 2011 NQO1 plays an important role in detoxification of benzene-derived quinones but plays a role in numerous other non-metabolic cellular functions. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 21745495-5 2011 METHODS: We extracted the endogenous quinones from wildtype (N2) and clk-1 mitochondria, replenished them with exogenous ubiquinones, and measured ETC activities. Quinones 37-45 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 69-74 20846517-11 2011 Thus, based on theoretical and experimental evidence, the oxidation of para- and ortho-hydroquinones to their corresponding electrophilic quinones is a requisite step for the activation of the Keap1/Nrf2/ARE pathway. Quinones 92-100 kelch like ECH associated protein 1 Homo sapiens 193-198 20846517-11 2011 Thus, based on theoretical and experimental evidence, the oxidation of para- and ortho-hydroquinones to their corresponding electrophilic quinones is a requisite step for the activation of the Keap1/Nrf2/ARE pathway. Quinones 92-100 NFE2 like bZIP transcription factor 2 Homo sapiens 199-203 20932822-4 2011 Pre-treatment of Nrf2(+/+) MEF cells with 3muM Sul for 18h prior to challenge with xenobiotics, conferred between 2.0- and 4.0-fold protection against isothiocyanates, reactive carbonyls, peroxides, quinones, NaAsO(2), and the anticancer nitrogen mustard chlorambucil, but pre-treatment with 3muM Sul produced no such increased tolerance in Nrf2(-/-) MEF cells. Quinones 199-207 nuclear factor, erythroid derived 2, like 2 Mus musculus 17-21 20361926-1 2010 NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-41 21479364-1 2011 NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. Quinones 113-121 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 21479364-1 2011 NAD(P)H:quinone oxidoreductase 1 (NQO1), is a cytosolic flavoenzyme that catalyzes the two-electron reduction of quinones into hydroquinones. Quinones 113-121 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 21220430-10 2011 Moreover, we found that the bound UQ can reversibly dissociate from Ndi1 and is thus replaceable with other quinones in the membrane. Quinones 108-116 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 68-72 20835842-1 2011 Human zeta-crystallin is a Zn(2+)-lacking medium-chain dehydrogenase/reductase (MDR) included in the quinone oxidoreductase (QOR) family because of its activity with quinones. Quinones 166-174 crystallin zeta Homo sapiens 101-123 20835842-1 2011 Human zeta-crystallin is a Zn(2+)-lacking medium-chain dehydrogenase/reductase (MDR) included in the quinone oxidoreductase (QOR) family because of its activity with quinones. Quinones 166-174 crystallin zeta Homo sapiens 125-128 20851755-8 2010 We then checked quinone-bound proteins as quinones produced by COX-2 bind to intracellular proteins. Quinones 42-50 prostaglandin-endoperoxide synthase 2 Homo sapiens 63-68 20980080-4 2010 Quinones 7 and 9, which exhibited the highest selective indexes (5.73 and 6.29, respectively), were further characterized using the following assays: Colony formation, caspase-3 activity, and ATP content. Quinones 0-8 caspase 3 Homo sapiens 168-177 20852777-4 2010 The entrapped tyrosinase could carry out enzyme-catalyzed oxidation of phenol to produce quinones, which subsequently quenched the fluorescence of QDs within hydrogel microarray. Quinones 89-97 tyrosinase Homo sapiens 14-24 21354283-3 2011 Results from in vitro experiments confirmed that the production of estrogen quinone-derived adducts on serum Alb increased with increased concentration of estrogen quinones. Quinones 164-172 albumin Homo sapiens 109-112 21285336-7 2011 The results of these studies indicate that both trans- and cis-amide isomers of the hydroquinone ansamycins exhibited increased binding affinity for Hsp90 relative to their parent quinones. Quinones 180-188 heat shock protein 90 alpha family class A member 1 Homo sapiens 149-154 21192729-0 2011 Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. Quinones 287-295 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 45-64 21192729-0 2011 Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. Quinones 287-295 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 108-127 21192729-0 2011 Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. Quinones 287-295 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 129-133 21192729-0 2011 Screening natural products for inhibitors of quinone reductase-2 using ultrafiltration LC-MS. Inhibitors of quinone reductase-2 (NQO2; QR-2) can have antimalarial activity and antitumor activities or can function as chemoprevention agents by preventing the metabolic activation of toxic quinones such as menadione. Quinones 287-295 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 135-139 21255087-2 2011 The melanocyte specificity is attributed to the tyrosinase-catalysed production of haptogenic ortho-quinones that covalently bind to tyrosinase or other melanosomal proteins to generate neo-antigens. Quinones 100-108 tyrosinase Homo sapiens 48-58 21255087-2 2011 The melanocyte specificity is attributed to the tyrosinase-catalysed production of haptogenic ortho-quinones that covalently bind to tyrosinase or other melanosomal proteins to generate neo-antigens. Quinones 100-108 tyrosinase Homo sapiens 133-143 20695893-8 2010 Recent reports have demonstrated that CCl(4) dechlorination rates are enhanced by redox-active organic compounds such as humic acids and quinones, which act as shuttles between electron-providing microorganisms and CCl(4) as a strong electron acceptor. Quinones 137-145 C-C motif chemokine ligand 4 Homo sapiens 38-44 20695893-8 2010 Recent reports have demonstrated that CCl(4) dechlorination rates are enhanced by redox-active organic compounds such as humic acids and quinones, which act as shuttles between electron-providing microorganisms and CCl(4) as a strong electron acceptor. Quinones 137-145 C-C motif chemokine ligand 4 Homo sapiens 215-221 20361926-1 2010 NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes, at rates that are comparable with NADH or NADPH. Quinones 150-158 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-47 20583790-2 2010 These two rates are attributed to reactions involving the quinones bound primarily by the PsaB (PhQ(B)) and PsaA (PhQ(A)) subunits, respectively. Quinones 58-66 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 90-94 20530481-7 2010 PON2 left O(2)(-) dismutase activities and cytochrome c expression unaltered, and it did not oxidize O(2)(-) but rather prevented its formation, which implies that PON2 acts by modulating quinones. Quinones 188-196 paraoxonase 2 Homo sapiens 0-4 20530481-7 2010 PON2 left O(2)(-) dismutase activities and cytochrome c expression unaltered, and it did not oxidize O(2)(-) but rather prevented its formation, which implies that PON2 acts by modulating quinones. Quinones 188-196 paraoxonase 2 Homo sapiens 164-168 20399199-1 2010 Quinone reductase 2 is a cytosolic enzyme which catalyses the reduction of quinones, such as menadione and coenzymes Q. Quinones 75-83 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-19 20399199-5 2010 QR2 has a powerful capacity to activate quinones leading to unexpected toxicity situations. Quinones 40-48 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-3 20604547-5 2010 The study also showed that the one-electron reduction potentials of quinones in DMSO are linearly dependent on the sum of the Hammett substituent parameters sigma(p): E(NHE)(p-Q/p-Q(*-)) = 0.45Sigma sigma(p) - 0.194 (V) and E(NHE)(o-Q/o-Q(*-)) = 0.45Sigma sigma(p) - 0.059 (V). Quinones 68-76 solute carrier family 9 member C1 Homo sapiens 169-172 20604547-5 2010 The study also showed that the one-electron reduction potentials of quinones in DMSO are linearly dependent on the sum of the Hammett substituent parameters sigma(p): E(NHE)(p-Q/p-Q(*-)) = 0.45Sigma sigma(p) - 0.194 (V) and E(NHE)(o-Q/o-Q(*-)) = 0.45Sigma sigma(p) - 0.059 (V). Quinones 68-76 solute carrier family 9 member C1 Homo sapiens 226-229 20204281-1 2010 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in metabolism of quinones and may perform multiple functions within the cell. Quinones 82-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 20153715-5 2010 Cytotoxic and oxidative action was paralleled by stimulation of stress signaling: all tested quinones except lawsone and lapachol strongly induced phosphorylation of the epidermal growth factor receptor (EGFR) and the related ErbB2 receptor tyrosine kinase. Quinones 93-101 epidermal growth factor receptor Homo sapiens 170-202 20153715-5 2010 Cytotoxic and oxidative action was paralleled by stimulation of stress signaling: all tested quinones except lawsone and lapachol strongly induced phosphorylation of the epidermal growth factor receptor (EGFR) and the related ErbB2 receptor tyrosine kinase. Quinones 93-101 epidermal growth factor receptor Homo sapiens 204-208 20153715-5 2010 Cytotoxic and oxidative action was paralleled by stimulation of stress signaling: all tested quinones except lawsone and lapachol strongly induced phosphorylation of the epidermal growth factor receptor (EGFR) and the related ErbB2 receptor tyrosine kinase. Quinones 93-101 erb-b2 receptor tyrosine kinase 2 Homo sapiens 226-231 20382756-9 2010 This study will help to guide future studies on characterizing the NQO1-mediated reduction and subsequent glucuronidation of other quinones. Quinones 131-139 NAD(P)H quinone dehydrogenase 1 Homo sapiens 67-71 20226854-2 2010 NQO1 is mainly a cytosolic enzyme which catalyzes the metabolism of quinones and is present in almost all tissue types providing protection against different stresses including xenobiotics, oxidants, UV light, and ionizing radiation. Quinones 68-76 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 20204281-1 2010 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme involved in metabolism of quinones and may perform multiple functions within the cell. Quinones 82-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 19941840-5 2010 NQO1 may also impact pathways in addition to metabolism of quinones due to protein-protein interactions or other mechanisms related to NQO1 activity. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 20460701-0 2010 Effects of tetrahydropterines on the generation of quinones catalyzed by tyrosinase. Quinones 51-59 tyrosinase Homo sapiens 73-83 20103645-1 2010 The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling. Quinones 106-114 NAD(P)H dehydrogenase, quinone 1 Mus musculus 38-42 20103645-1 2010 The cytosolic quinone oxidoreductases NQO1 and NQO2 protect cells against oxidative stress by detoxifying quinones and preventing redox cycling. Quinones 106-114 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 47-51 20142043-7 2010 Thus, the oxidation of para- and ortho-hydroquinones to quinones represents the rate-limiting step in the activation of Nrf2. Quinones 44-52 NFE2 like bZIP transcription factor 2 Homo sapiens 120-124 19932179-2 2010 Our understanding of the chemistry of cuticular sclerotization has increased considerably since Mark Pryor in 1940 suggested that enzymatically generated ortho-quinones react with free amino groups, thereby crosslinking the cuticular proteins. Quinones 160-168 microtubule affinity regulating kinase 1 Homo sapiens 96-100 19931366-6 2010 The catechol metabolites of alpha-ZAL and ZAN are unstable and readily oxidized to quinones, which could be detected among the metabolites of alpha-ZAL and ZAN generated by human hepatic microsomes and hCYP1A2. Quinones 83-91 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 202-209 20067291-4 2010 Presently there exist only a few compounds that have been reported to inhibit Ape1 redox activity; here we describe a series of quinones that exhibit micromolar inhibition of the redox function of Ape1. Quinones 128-136 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 78-82 20067291-4 2010 Presently there exist only a few compounds that have been reported to inhibit Ape1 redox activity; here we describe a series of quinones that exhibit micromolar inhibition of the redox function of Ape1. Quinones 128-136 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 197-201 19941471-11 2010 Natural products continue to provide structurally complex, but highly original lead structures for drug discovery programs: polyphenols, quinones, and terpenoids showed to affect the Trx/TrxR system at different levels. Quinones 137-145 thioredoxin Homo sapiens 183-186 19941471-11 2010 Natural products continue to provide structurally complex, but highly original lead structures for drug discovery programs: polyphenols, quinones, and terpenoids showed to affect the Trx/TrxR system at different levels. Quinones 137-145 peroxiredoxin 5 Homo sapiens 187-191 19628038-2 2009 NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 19952498-7 2009 These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1. Quinones 141-149 nuclear factor, erythroid derived 2, like 2 Mus musculus 27-31 19952498-7 2009 These results suggest that Nrf2 activation during redox cycling of catechol estrogens is dominantly attributable to formation of their ortho-quinones that covalently bind to Keap1. Quinones 141-149 kelch-like ECH-associated protein 1 Mus musculus 174-179 19628038-2 2009 NAD(P)H:quinone oxidoreductase 1 (NQO1) reduces these quinones back to catechols, and thus may protect against this mechanism. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 19618916-8 2009 Interestingly, both half-reactions of the catalytic cycle strongly resemble bioorganic model reactions; the reduction of Lot6p by NAD(P)H is moderately faster than nonenzymatic models, while the oxidation of Lot6p by quinones is actually slower than nonenzymatic reactions. Quinones 217-225 flavin-dependent quinone reductase Saccharomyces cerevisiae S288C 121-126 19618916-8 2009 Interestingly, both half-reactions of the catalytic cycle strongly resemble bioorganic model reactions; the reduction of Lot6p by NAD(P)H is moderately faster than nonenzymatic models, while the oxidation of Lot6p by quinones is actually slower than nonenzymatic reactions. Quinones 217-225 flavin-dependent quinone reductase Saccharomyces cerevisiae S288C 208-213 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 222-254 19362588-7 2009 On oxidation, polyphenols with B-ring catechol functionality form toxic alkylating quinones that are normally inactivated by cellular antioxidant defense and redox maintenance systems, including reduction by ascorbate and NAD(P)H:quinone oxidoreductase 1 (NQO1). Quinones 83-91 NAD(P)H quinone dehydrogenase 1 Homo sapiens 256-260 19236154-4 2009 Two strategies are known to increase Nrf2 transcriptional activity in PD: i) use of certain catechol-derived quinones for selective inhibition of the Nrf2 repressor Kelch-like ECH-associated protein to increase of Nrf2 protein levels; and ii) use of glycogen synthase kinase 3beta inhibitors to maintain high protein and activity levels of Nrf2 in the nucleus. Quinones 109-117 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 19351655-1 2009 We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones and its ability to stabilize p53. Quinones 170-178 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 21-49 19351655-1 2009 We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones and its ability to stabilize p53. Quinones 170-178 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 51-55 19351655-1 2009 We hypothesized that NRH:quinone oxidoreductase 2 (NQO2) is a candidate susceptibility gene for breast cancer because of its known enzymatic activity on estrogen-derived quinones and its ability to stabilize p53. Quinones 170-178 tumor protein p53 Homo sapiens 208-211 19445526-1 2009 NRH:quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes a one-step two-electron reduction of quinones. Quinones 105-113 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-28 19445526-1 2009 NRH:quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes a one-step two-electron reduction of quinones. Quinones 105-113 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 30-34 19122194-8 2009 Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes. Quinones 119-127 succinate dehydrogenase complex iron sulfur subunit B Homo sapiens 20-24 19122194-8 2009 Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes. Quinones 119-127 succinate dehydrogenase complex subunit C Homo sapiens 44-48 19122194-8 2009 Catalytic subunits (SDH1, SDH2N plus SDH2C, SDH3, and SDH4) contain all key residues for binding of dicarboxylates and quinones, but the enzyme showed the lower affinity for both substrates and inhibitors than mammalian enzymes. Quinones 119-127 succinate dehydrogenase complex subunit D Homo sapiens 54-58 19250193-6 2009 Using rate constants of genetic variants of CYP1A1, CYP1B1, and COMT, the model further allowed examination of the kinetic impact of enzyme polymorphisms on the entire metabolic pathway, including the identification of those haplotypes producing the largest amounts of catechols and quinones. Quinones 283-291 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 52-58 19250193-6 2009 Using rate constants of genetic variants of CYP1A1, CYP1B1, and COMT, the model further allowed examination of the kinetic impact of enzyme polymorphisms on the entire metabolic pathway, including the identification of those haplotypes producing the largest amounts of catechols and quinones. Quinones 283-291 catechol-O-methyltransferase Homo sapiens 64-68 19250193-6 2009 Using rate constants of genetic variants of CYP1A1, CYP1B1, and COMT, the model further allowed examination of the kinetic impact of enzyme polymorphisms on the entire metabolic pathway, including the identification of those haplotypes producing the largest amounts of catechols and quinones. Quinones 283-291 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 18972140-1 2009 Tyrosinase catalyzes the ortho hydroxylation of monophenols and the subsequent oxidation of the diphenolic products to the resulting quinones. Quinones 133-141 tyrosinase Homo sapiens 0-10 18996184-0 2009 Evidence for NQO2-mediated reduction of the carcinogenic estrogen ortho-quinones. Quinones 72-80 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 13-17 18996184-1 2009 The physiological function of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase) is to detoxify potentially reactive quinones by direct transfer of two electrons. Quinones 119-127 crystallin zeta Homo sapiens 38-60 18996184-1 2009 The physiological function of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase) is to detoxify potentially reactive quinones by direct transfer of two electrons. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-66 18996184-1 2009 The physiological function of NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase) is to detoxify potentially reactive quinones by direct transfer of two electrons. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 68-81 18996184-4 2009 In this investigation, we have shown for the first time that NQO2 catalyzes the reduction of electrophilic estrogen quinones and thereby may act as a detoxification enzyme. Quinones 116-124 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 61-65 18996184-10 2009 Preliminary kinetic studies show that NQO2 is faster in reducing estrogen quinones than its homologue NQO1. Quinones 74-82 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 38-42 18996184-10 2009 Preliminary kinetic studies show that NQO2 is faster in reducing estrogen quinones than its homologue NQO1. Quinones 74-82 NAD(P)H quinone dehydrogenase 1 Homo sapiens 102-106 19536200-6 2009 In support of this hypothesis, quinone-linked ArcA and Fur target expressions were significantly less perturbed by isobutanol under fermentative growth whereas quinol-linked PhoB target expressions remained activated, and isobutanol impeded growth on glycerol, which requires quinones, more than on glucose. Quinones 276-284 arginine deiminase Escherichia coli 46-50 19082175-6 2009 An applied potential of -200 mV vs. Ag/AgC1 applied to the biocomposite based electrode was found to be optimal for electrochemical reduction of the enzymatic reaction products (quinones). Quinones 178-186 aggrecan Homo sapiens 39-43 19105592-3 2009 We found that human recombinant PGHS-2 catalyzed the oxidation of ortho (2",3"- and 3",4"-) and para (2",5"-) dihydroxy 4-chlorobiphenyl metabolites to their corresponding quinones. Quinones 172-180 prostaglandin-endoperoxide synthase 2 Homo sapiens 32-38 18839991-5 2008 Here we describe the synthesis of selected PCB metabolites with differing degrees of chlorination on the oxygenated phenyl ring, e.g., 4,4"-dichloro-biphenyl-2,5-diol, 3,6,4"-trichloro-biphenyl-2,5-diol, 3,4,6,-trichloro-biphenyl-2,5-diol, and their corresponding quinones. Quinones 264-272 pyruvate carboxylase Homo sapiens 43-46 18826943-1 2008 Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. Quinones 188-196 carbonyl reductase 1 Homo sapiens 6-26 18826943-1 2008 Human carbonyl reductase 1 (hCBR1) is an NADPH-dependent short chain dehydrogenase/reductase with broad substrate specificity and is thought to be responsible for the in vivo reduction of quinones, prostaglandins, and other carbonyl-containing compounds including xenobiotics. Quinones 188-196 carbonyl reductase 1 Homo sapiens 28-33 18474416-1 2008 NAD(P)H:quinone oxidoreductase (Nqo1)-mediated detoxification of quinones plays a critical role in cancer prevention. Quinones 65-73 NAD(P)H dehydrogenase, quinone 1 Mus musculus 32-36 18534861-1 2008 Benzoquinone reductase (BR; EC 1.6.5.7) is an enzyme which catalyzes the bivalent redox reactions of quinones without the production of free radical intermediates. Quinones 101-109 probable NAD(P)H dehydrogenase (quinone) FQR1-like 1 Gossypium hirsutum 0-22 18534861-1 2008 Benzoquinone reductase (BR; EC 1.6.5.7) is an enzyme which catalyzes the bivalent redox reactions of quinones without the production of free radical intermediates. Quinones 101-109 probable NAD(P)H dehydrogenase (quinone) FQR1-like 1 Gossypium hirsutum 24-26 19198139-6 2008 (3) The catechol-derived quinones are candidate molecules to facilitate the oligomer formation of a-synuclein. Quinones 25-33 synuclein alpha Homo sapiens 98-109 18519585-9 2008 We propose that the involvement of DDC in a new pathway involved in Drosophila immunity increases the levels of dopamine, which is metabolized to produce reactive quinones that exert an antimicrobial effect on invading bacteria. Quinones 163-171 Dopa decarboxylase Drosophila melanogaster 35-38 18588320-0 2008 Problematic detoxification of estrogen quinones by NAD(P)H-dependent quinone oxidoreductase and glutathione-S-transferase. Quinones 39-47 glutathione S-transferase kappa 1 Homo sapiens 96-121 18254726-3 2008 Initially, QR2 was believed to function analogously to QR1 in protecting cells from highly reactive quinones. Quinones 100-108 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 11-14 18254726-3 2008 Initially, QR2 was believed to function analogously to QR1 in protecting cells from highly reactive quinones. Quinones 100-108 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-58 19138946-3 2008 Genotoxicity may be caused by cytochrome P450 (CYP)-mediated oxidation of catechol estrogens to quinones that react with DNA to form depurinating estrogen-DNA adducts. Quinones 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-45 19138946-3 2008 Genotoxicity may be caused by cytochrome P450 (CYP)-mediated oxidation of catechol estrogens to quinones that react with DNA to form depurinating estrogen-DNA adducts. Quinones 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-50 19138946-4 2008 CYP1B1 favors quinone formation by catalyzing estrogen 4-hydroxylation, whereas NAD(P)H quinone oxidoreductase 1 (NQO1) catalyzes the protective reduction of quinones to catechols. Quinones 158-166 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 18489080-7 2008 An RP-HPLC-ECD assay was used to detect the formation of 8-oxo-dGuo in p53 cDNA exposed to representative quinones, BP-7,8-dione, BA-3,4-dione, and DMBA-3,4-dione under redox cycling conditions. Quinones 106-114 tumor protein p53 Homo sapiens 71-74 18423374-7 2008 The results suggest possible detoxification pathways for quinones via NQO1 reduction followed by UGT glucuronidation. Quinones 57-65 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-74 18423374-7 2008 The results suggest possible detoxification pathways for quinones via NQO1 reduction followed by UGT glucuronidation. Quinones 57-65 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 97-100 18512969-3 2008 The reaction leads to two catechol estrogen quinones, CE1-2,3-Q and CE1-3,4-Q, both of which react via Michael additions to afford 4-OH-E1-1-N3Ade and other DNA adducts. Quinones 44-52 carboxylesterase 1 Homo sapiens 54-57 18455424-2 2008 Because oxidative stress caused by dopamine oxidation to dopamine quinone is suggested as a major factor contributing to the pathogenesis of PD, the induction of the enzyme that catalyzes the reduction of quinones, NAD(P)H quinone oxidoreductase1 (NQO1), could be a desirable therapeutic strategy to protect cells from oxidative damage. Quinones 205-213 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 248-252 18379100-2 2008 The results indicate that the quinones derived from oxidation of 2,5-dihydroxybenzoic acid and 3,4-dihydroxybenzaldehyde participate in Michael addition reactions with 3-hydroxy-1H-phenalene-1-one and via ECE and ECEC mechanisms convert to the different products, with good yield under controlled potential conditions, at carbon electrode. Quinones 30-38 endothelin converting enzyme 1 Homo sapiens 205-208 19096098-5 2008 Some short chain quinones are Complex I inhibitors (CoQ2, idebenone and its derivatives), while CoQ1, decylubiquinone~ (DB) and duroquinone (DQ) are good electron acceptors from Complex I. Quinones 17-25 decaprenyl diphosphate synthase subunit 1 Homo sapiens 96-100 18264564-0 2008 Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential. Quinones 22-30 NAD(P)H quinone dehydrogenase 1 Homo sapiens 83-87 18264564-1 2008 The quinone reductase enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the two-electron reduction of quinones. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 29-62 18264564-1 2008 The quinone reductase enzyme NAD(P)H: quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes the two-electron reduction of quinones. Quinones 143-151 NAD(P)H quinone dehydrogenase 1 Homo sapiens 64-68 18264564-2 2008 This Perspective briefly reviews the structure and mechanism, physiological role, and upregulation and induction of the enzyme, but focuses on the synthesis of new heterocyclic quinones and their metabolism by recombinant human NQO1. Quinones 177-185 NAD(P)H quinone dehydrogenase 1 Homo sapiens 228-232 18279387-5 2008 More importantly, we found that ATP facilitates the autophosphorylation of 2-Cys Prx when the protein is successively reduced with thiol-bearing compounds and oxidized with hydroperoxides or quinones. Quinones 191-199 periaxin Homo sapiens 81-84 18253865-2 2008 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 18253865-2 2008 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes the two-electron reduction of quinones, preventing their participation in redox cycling and subsequent generation of reactive oxygen species. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 18314446-1 2008 The N-ribosyldihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2) gene encodes an enzyme that catalyzes activation of quinones. Quinones 123-131 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 4-63 18314446-1 2008 The N-ribosyldihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2) gene encodes an enzyme that catalyzes activation of quinones. Quinones 123-131 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 65-69 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 26-34 crystallin zeta Homo sapiens 56-78 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 26-34 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 136-144 crystallin zeta Homo sapiens 56-78 19096102-1 2008 Two-electron reduction of quinones catalyzed by NAD(P)H:quinone oxidoreductase (NQO1) protects cells against oxidative stress and toxic quinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 80-84 19096102-2 2008 In fact, low level of NQO1 activity is often associated with increased risk of developing different types of tumours and with toxic effects linked to environmental quinones. Quinones 164-172 NAD(P)H quinone dehydrogenase 1 Homo sapiens 22-26 17975886-2 2007 Drugs bioactivated to quinones have the potential to activate antioxidant/electrophile responsive element (ARE) transcription of genes for cytoprotective phase 2 enzymes such as NAD(P)H-dependent quinone oxidoreductase (NQO1) but can also cause cellular damage. Quinones 22-30 NAD(P)H quinone dehydrogenase 1 Homo sapiens 220-224 18052105-9 2008 DNA damage induced by these equine quinones is significantly increased in cells containing ERs, leading us to hypothesize a mechanism involving ER binding/alkylation by the catchol/quinone, resulting in a "Trojan horse". Quinones 35-43 estrogen receptor 1 Equus caballus 91-93 18022268-1 2008 The neurotoxicity of dopamine (DA) quinones as dopaminergic neuron-specific oxidative stress is considered to play a role in the pathogenesis and/or progression of Parkinson"s disease (PD), since DA quinones conjugate with several key PD pathogenic molecules (e.g., tyrosine hydroxylase, alpha-synuclein and parkin) to form protein-bound quinone (quinoprotein) and consequently inhibit their functions. Quinones 35-43 synuclein, alpha Mus musculus 288-303 18374190-2 2008 The main function of QR1 is probably the detoxification of dietary quinones but it may also contribute to the reduction of vitamin K for its involvement in blood coagulation. Quinones 67-75 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-24 18374190-3 2008 In addition, the same reaction that QR1 uses in the detoxification of quinones, activates some compounds making them cytotoxic. Quinones 70-78 NAD(P)H quinone dehydrogenase 1 Homo sapiens 36-39 17893042-0 2007 Evidence from ESI-MS for NQO1-catalyzed reduction of estrogen ortho-quinones. Quinones 68-76 NAD(P)H quinone dehydrogenase 1 Homo sapiens 25-29 17964424-4 2007 Catechol-O-methyltransferase (COMT) is considered an important enzyme that protects cells from the genotoxicity and cytotoxicity of catechol estrogens, by preventing their conversion to quinones. Quinones 186-194 catechol-O-methyltransferase Homo sapiens 0-28 17964424-4 2007 Catechol-O-methyltransferase (COMT) is considered an important enzyme that protects cells from the genotoxicity and cytotoxicity of catechol estrogens, by preventing their conversion to quinones. Quinones 186-194 catechol-O-methyltransferase Homo sapiens 30-34 17971996-2 2007 The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Quinones 34-42 NAD(P)H quinone dehydrogenase 1 Homo sapiens 118-122 17971996-3 2007 Overall, the quinones were excellent substrates for NQO1. Quinones 13-21 NAD(P)H quinone dehydrogenase 1 Homo sapiens 52-56 17893042-3 2007 In this investigation, we were successful in circumventing the problem of nonenzymatic reduction of estrogen quinone by NAD(P)H, which led to the above conclusion, and for the first time we show that NQO1 catalyzes the reduction of estrogen quinones. Quinones 241-249 NAD(P)H quinone dehydrogenase 1 Homo sapiens 200-204 17893042-11 2007 Thus, clear evidence for the catalytic reduction of estrogen ortho-quinones by NQO1 has been obtained; its mechanism and implications are discussed. Quinones 67-75 NAD(P)H quinone dehydrogenase 1 Homo sapiens 79-83 17714848-1 2007 NRH:quinone oxidoreductase 2 (QR2) is a long forgotten oxidoreductive enzyme that metabolizes quinones and binds melatonin. Quinones 94-102 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 0-28 17942934-1 2007 NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that catalyzes the two-electron reduction of quinones and quinoid compounds to hydroquinones. Quinones 109-117 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 0-28 17942934-1 2007 NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that catalyzes the two-electron reduction of quinones and quinoid compounds to hydroquinones. Quinones 109-117 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 30-34 17883274-0 2007 Tyrosinase-generated quinones induce covalent modification, unfolding, and aggregation of human holo-myoglobin. Quinones 21-29 tyrosinase Homo sapiens 0-10 17714848-1 2007 NRH:quinone oxidoreductase 2 (QR2) is a long forgotten oxidoreductive enzyme that metabolizes quinones and binds melatonin. Quinones 94-102 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 30-33 17629694-1 2007 The effects of flavonoids and quinones on NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice. Quinones 30-38 aldo-keto reductase family 1, member C18 Mus musculus 68-104 17629694-1 2007 The effects of flavonoids and quinones on NADPH- and NADH-dependent 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice. Quinones 30-38 aldo-keto reductase family 1, member C18 Mus musculus 106-117 17629694-2 2007 Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities. Quinones 111-119 aldo-keto reductase family 1, member C18 Mus musculus 70-81 17629694-2 2007 Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities. Quinones 111-119 aldo-keto reductase family 1, member C18 Mus musculus 161-172 17629694-2 2007 Judging from the data for the inhibition of NADPH- and NADH-dependent 20alpha-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20alpha-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20alpha-HSD activities. Quinones 111-119 aldo-keto reductase family 1, member C18 Mus musculus 161-172 17535857-10 2007 Real-time quantitative RT-PCR analysis showed significant elevation in the mRNA levels of HO-1 and two other phase 2 enzymes, the regulatory subunit of glutamyl cysteine ligase, which is needed for the synthesis of glutathione, and NAD(P)H:quinone oxidoreductase, which detoxifies quinones. Quinones 281-289 heme oxygenase 1 Mus musculus 90-94 17850508-5 2007 Such reactive quinones can be covalently bound to the catalytic centre of tyrosinase (haptenation). Quinones 14-22 tyrosinase Homo sapiens 74-84 17651437-2 2007 Polyphenol oxidase (PPO) catalyzes the oxidation of o-diphenols to their respective quinones. Quinones 84-92 protoporphyrinogen oxidase Homo sapiens 0-18 17676875-0 2007 Horse heart myoglobin catalyzes the H2O2-dependent oxidative dehalogenation of chlorophenols to DNA-binding radicals and quinones. Quinones 121-129 myoglobin Equus caballus 12-21 17651437-2 2007 Polyphenol oxidase (PPO) catalyzes the oxidation of o-diphenols to their respective quinones. Quinones 84-92 protoporphyrinogen oxidase Homo sapiens 20-23 17305492-12 2007 In conclusion, a novel intestinal metabolic pathway for quinones, NQO1 mediated reduction and subsequent glucuronidation, was determined using TS as a model compound. Quinones 56-64 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 66-70 17188792-3 2007 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme with antioxidant properties that is responsible for the reduction of cellular quinones. Quinones 131-139 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 17570247-0 2007 Cytochrome P450 isoforms catalyze formation of catechol estrogen quinones that react with DNA. Quinones 65-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 17570247-3 2007 These, in turn, are oxidized to the quinones, E(2)-3,4-quinone (E(2)-3,4-Q) and E(2)-2,3-Q, which can react with DNA. Quinones 36-44 cystatin 12, pseudogene Homo sapiens 46-52 17570247-3 2007 These, in turn, are oxidized to the quinones, E(2)-3,4-quinone (E(2)-3,4-Q) and E(2)-2,3-Q, which can react with DNA. Quinones 36-44 cystatin 12, pseudogene Homo sapiens 64-70 17570247-3 2007 These, in turn, are oxidized to the quinones, E(2)-3,4-quinone (E(2)-3,4-Q) and E(2)-2,3-Q, which can react with DNA. Quinones 36-44 transcription factor 4 Homo sapiens 80-86 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. Quinones 122-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. Quinones 122-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 44-50 17570247-11 2007 These experiments demonstrated that CYP1A1, CYP1B1, and CYP3A4 are able to oxidize catechol estrogens to their respective quinones, which can further react with GSH, protein, and DNA, the last resulting in depurinating adducts that can lead to mutagenesis. Quinones 122-130 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 56-62 17395592-4 2007 Among the possible targets of quinones, alpha-synuclein is of primary interest because of its direct involvement in dopamine metabolism. Quinones 30-38 synuclein alpha Homo sapiens 40-55 17395592-8 2007 After the spectroscopic characterization of the products derived from the oxidation of dopamine, the structural information obtained was used to analyze the reactivity of quinones toward alpha-synuclein. Quinones 171-179 synuclein alpha Homo sapiens 187-202 17188792-3 2007 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme with antioxidant properties that is responsible for the reduction of cellular quinones. Quinones 131-139 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 17023004-9 2006 Treatments with superoxide dismutase and catalase suggests the possible generation of reactive oxygen species by redox cycling of various forms of quinones, similar to estrogens, that are the results of aromatic hydroxylation by cytochrome P450s. Quinones 147-155 catalase Homo sapiens 41-49 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. Quinones 142-150 crystallin zeta Homo sapiens 57-79 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 81-85 17546202-5 2007 A comparison of X-ray data of PETNR, mammalian NAD(P)H : quinone oxidoreductase (NQO1), and Enterobacter cloacae nitroreductase, which reduce quinones in a two-electron way, and their reactivity revealed that PETNR is much less reactive, and much less sensitive to the quinone substrate steric effects than NQO1. Quinones 142-150 NAD(P)H quinone dehydrogenase 1 Homo sapiens 307-311 17234793-5 2007 Because the reactive quinones were produced as part of the CYP1B1-mediated oxidation reaction, the adduct formation followed Michaelis-Menten kinetics. Quinones 21-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-65 17009925-5 2007 These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. Quinones 231-239 carbonyl reductase 1 Homo sapiens 137-141 17009925-5 2007 These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. Quinones 231-239 crystallin zeta Homo sapiens 146-169 17009925-5 2007 These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted. Quinones 231-239 NAD(P)H quinone dehydrogenase 1 Homo sapiens 171-175 17396564-1 2007 Phytogenous flavonoid-containing agents (PFCA) are able to initiate electron flow bypassing the NAD-dependent region of respiratory chain, which is related with the activity of DT-diaphorase catalyzing two-electron reduction of quinones to hydroquinones and hydrogen peroxide in the presence of NADH and oxygen. Quinones 228-236 NAD(P)H quinone dehydrogenase 1 Homo sapiens 177-190 16963132-6 2006 Like trout CYP1A1, cDNA-expressed zCYP1A was found to oxidize BaP to phenols, quinones and diols (BaP-7,8-diol and BaP-9,10-diol) in the presence of exogenous human microsomal epoxide hydrolase (hEH). Quinones 78-86 cytochrome P450, family 1, subfamily A Danio rerio 34-40 16989769-2 2006 This mutant (PsaB:W669G) was studied using EPR spectroscopy with a view to understanding the molecular basis of the reported kinetic differences in forward electron transfer from the A(1A) and the A(1B) phyllo(semi)quinones. Quinones 215-223 photosystem I P700 chlorophyll a apoprotein A2 Chlamydomonas reinhardtii 13-18 16978807-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) can metabolize dopamine-derived quinones (DAQ) and absence of NQO1 due to the NQO1*2 polymorphism has been suggested to be a risk factor for Parkinson"s disease. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 16978807-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) can metabolize dopamine-derived quinones (DAQ) and absence of NQO1 due to the NQO1*2 polymorphism has been suggested to be a risk factor for Parkinson"s disease. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 17017857-2 2006 The cytotoxic effects of these quinones are mainly due to the following two factors: (i) inhibition of DNA topoisomerase-II and, (ii) formation of semiquinone radical that can transfer an electron to oxygen to produce super oxide, which is catalyzed by flavoenzymes such as NADPH-cytochrome-P-450 reductase. Quinones 31-39 cytochrome p450 oxidoreductase Homo sapiens 274-306 16905546-1 2006 NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives. Quinones 139-147 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 16905546-1 2006 NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives. Quinones 139-147 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 16905546-1 2006 NAD(P)H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze metabolic reduction of quinones and derivatives. Quinones 139-147 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 74-78 16825487-4 2006 Inhibition of purified yeast Hsp90 ATPase activity was augmented in the presence of NQO1 and abrogated by 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl-]indole-4,7-dione (ES936), a mechanism-based inhibitor of NQO1, showing that the hydroquinone ansamycins were more potent Hsp90 inhibitors than their parent quinones. Quinones 312-320 Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C 29-34 16314070-1 2006 NAD(P)H:quinone oxidoreductase (NQO1)-mediated detoxification of quinones is suggested to be involved in cancer prevention. Quinones 65-73 crystallin zeta Homo sapiens 8-30 16985022-5 2006 The model also enables simulation for the transient quinones, E(2)-2,3-quinone (E(2)-2,3-Q) and E(2)-3,4-quinone (E(2)-3,4-Q), which are not amenable to direct quantitation. Quinones 52-60 transcription factor 4 Homo sapiens 80-86 16985022-6 2006 Using experimentally derived rate constants for genetic variants of CYP1A1, CYP1B1, and COMT, we used the model to simulate the kinetic effect of enzyme polymorphisms on the pathway and identified those haplotypes generating the largest amounts of catechols and quinones. Quinones 262-270 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 68-74 16985022-6 2006 Using experimentally derived rate constants for genetic variants of CYP1A1, CYP1B1, and COMT, we used the model to simulate the kinetic effect of enzyme polymorphisms on the pathway and identified those haplotypes generating the largest amounts of catechols and quinones. Quinones 262-270 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 76-82 16985022-6 2006 Using experimentally derived rate constants for genetic variants of CYP1A1, CYP1B1, and COMT, we used the model to simulate the kinetic effect of enzyme polymorphisms on the pathway and identified those haplotypes generating the largest amounts of catechols and quinones. Quinones 262-270 catechol-O-methyltransferase Homo sapiens 88-92 16314070-1 2006 NAD(P)H:quinone oxidoreductase (NQO1)-mediated detoxification of quinones is suggested to be involved in cancer prevention. Quinones 65-73 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16682409-1 2006 The NAD(P)H:quinone oxidoreductase 1 (NQO1) is a phase II enzyme that reduces and detoxifies quinones and their derivatives. Quinones 93-101 NAD(P)H dehydrogenase, quinone 1 Mus musculus 4-36 16765324-13 2006 These results concluded that NQO2 plays a significant role in the metabolic activation of both quinones and anti-tumor drugs leading to cytotoxicity and cell death. Quinones 95-103 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 29-33 16765324-0 2006 NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Quinones 70-78 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 0-28 16765324-0 2006 NRH:quinone oxidoreductase 2 (NQO2) catalyzes metabolic activation of quinones and anti-tumor drugs. Quinones 70-78 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 30-34 16765324-2 2006 The present studies investigate the role of NQO2 in metabolic detoxification/activation of quinones and quinone based anti-tumor drugs. Quinones 91-99 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 44-48 16682409-1 2006 The NAD(P)H:quinone oxidoreductase 1 (NQO1) is a phase II enzyme that reduces and detoxifies quinones and their derivatives. Quinones 93-101 NAD(P)H dehydrogenase, quinone 1 Mus musculus 38-42 16818284-1 2006 NAD(P)H:quinone oxidoreductase (NQO1) detoxifies quinones. Quinones 49-57 crystallin zeta Homo sapiens 8-30 16430935-2 2006 As the redox cycle is catalyzed by NADPH cytochrome P450 reductase, cytochrome P450 systems are expected to be related to the cytotoxicity induced by redox-cycling quinones. Quinones 164-172 cytochrome p450 oxidoreductase Rattus norvegicus 35-66 16430935-2 2006 As the redox cycle is catalyzed by NADPH cytochrome P450 reductase, cytochrome P450 systems are expected to be related to the cytotoxicity induced by redox-cycling quinones. Quinones 164-172 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 41-56 16430935-9 2006 These results indicate that the hepatocyte toxicity of redox-cycling quinones is enhanced under cytochrome P450 inhibition, and that this enhancement is caused by the potentiation of oxidative stress. Quinones 69-77 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 96-111 16818284-1 2006 NAD(P)H:quinone oxidoreductase (NQO1) detoxifies quinones. Quinones 49-57 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16706650-1 2006 A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the terminal oxidases. Quinones 85-93 tripartite motif containing 33 Homo sapiens 38-42 16706650-1 2006 A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the terminal oxidases. Quinones 85-93 tripartite motif containing 33 Homo sapiens 286-290 16505371-8 2006 Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Quinones 23-31 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 92-112 16700548-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 16700548-1 2006 NAD(P)H quinone oxidoreductase 1 (NQO1) is a ubiquitous flavoenzyme that catalyzes two-electron reduction of quinones to hydroquinones utilizing NAD(P)H as an electron donor. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 16505371-8 2006 Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Quinones 23-31 DNA damage inducible transcript 3 Homo sapiens 169-193 16505371-8 2006 Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Quinones 23-31 DNA damage inducible transcript 3 Homo sapiens 195-199 16545679-1 2006 Human NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic protein that catalyzes the metabolic reduction of quinones and provides protection against myelogenous hyperplasia and chemical carcinogenesis. Quinones 107-115 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 6-34 16545679-1 2006 Human NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic protein that catalyzes the metabolic reduction of quinones and provides protection against myelogenous hyperplasia and chemical carcinogenesis. Quinones 107-115 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 36-40 16505371-8 2006 Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Quinones 23-31 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 114-118 16505371-8 2006 Furthermore, arylating quinones induced endoplasmic reticulum (ER) stress by activating the pancreatic ER kinase (PERK) signaling pathway including elF2alpha, ATF4, and C/EBP homologous protein (CHOP). Quinones 23-31 activating transcription factor 4 Homo sapiens 159-163 16322759-2 2006 Another potential line of defence is the activation, by a proteolytic cascade, of phenoloxidase, which leads to the production of quinones and melanin. Quinones 130-138 Phox Drosophila melanogaster 82-95 16520231-6 2006 The pyrogallol moiety determined a low Q-TOX, suggesting the conversion of quinones into oxidation products of low toxicity. Quinones 75-83 thymocyte selection associated high mobility group box Homo sapiens 41-44 16562858-3 2006 Reduction of electrophilic quinones by quinone reductase is an important detoxification pathway. Quinones 27-35 crystallin, zeta Mus musculus 39-56 16510978-2 2006 Studies on human DHODH (HsDHODH) led to a structural mechanistic model in which respiratory quinones bind in a tunnel formed by the highly variable N-terminus that leads to the flavin mononucleotide-binding site. Quinones 92-100 dihydroorotate dehydrogenase (quinone) Homo sapiens 17-22 16291649-5 2005 We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions. Quinones 39-47 hypothetical protein Escherichia coli 87-91 16216500-0 2006 Synthesis and biological evaluation of novel heterocyclic quinones as inhibitors of the dual specificity protein phosphatase CDC25C. Quinones 58-66 cell division cycle 25C Homo sapiens 125-131 16216500-1 2006 A focused set of heterocyclic quinones based on the benzothiazole, benzoxazole, benzimidazole, indazole and isoindole was prepared and screened with respect to the inhibition of the phosphatase activity of CDC25C. Quinones 30-38 cell division cycle 25C Homo sapiens 206-212 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 24-32 estrogen receptor 1 Homo sapiens 113-115 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 24-32 estrogen receptor 1 Homo sapiens 166-168 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 145-153 estrogen receptor 1 Homo sapiens 113-115 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 145-153 estrogen receptor 1 Homo sapiens 166-168 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 145-153 estrogen receptor 1 Homo sapiens 166-168 16253210-2 2005 Because of its sequence homology with quinone reductase 1, it has been suspected to detoxify quinones. Quinones 93-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 38-57 16253210-6 2005 Finally QR2 might be implicated in the toxicity, in vivo, of quinones such as menadione. Quinones 61-69 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 8-11 17145690-3 2006 Exogenous or endogenous quinones can also induce ligand-independent nuclear translocation and phosphorylation of ER; with excess exposure, these quinones can arylate ER zinc fingers, impairing ER DNA-binding and altering ER-inducible gene expression. Quinones 24-32 estrogen receptor 1 Homo sapiens 166-168 17047300-4 2006 The catechol-derived quinones are the candidate molecules that facilitate the oligomer formation of alpha-synuclein. Quinones 21-29 synuclein alpha Homo sapiens 100-115 16320003-6 2006 RESULTS: All quinones tested were shown to inhibit JB6 Cl41 cell transformation, to induce apoptosis, AP-1, and NF-kappaB activity, and to inhibit p53 activity. Quinones 13-21 jun proto-oncogene Mus musculus 102-106 16320003-6 2006 RESULTS: All quinones tested were shown to inhibit JB6 Cl41 cell transformation, to induce apoptosis, AP-1, and NF-kappaB activity, and to inhibit p53 activity. Quinones 13-21 transformation related protein 53, pseudogene Mus musculus 147-150 16320003-8 2006 CONCLUSIONS: Quinones and demonstrated cancer-preventive activity in JB6 Cl41 cells, which may be attributed to the induction of p53-independent apoptosis. Quinones 13-21 transformation related protein 53, pseudogene Mus musculus 129-132 16291649-5 2005 We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions. Quinones 39-47 hypothetical protein Escherichia coli 163-167 16291649-5 2005 We suggest that the redox state of the quinones, which controls autophosphorylation of ArcB, not only monitors oxygen but also energy supply, and we show that the ArcB/ArcA/RssB system is involved in sigma(S) induction during entry into starvation conditions. Quinones 39-47 arginine deiminase Escherichia coli 168-172 16142378-4 2005 Formation of the quinones is prevented by methylation of the 4-catechol estrogens by the enzyme, catechol-O-methyltransferase (COMT). Quinones 17-25 catechol-O-methyltransferase Homo sapiens 97-125 16142378-4 2005 Formation of the quinones is prevented by methylation of the 4-catechol estrogens by the enzyme, catechol-O-methyltransferase (COMT). Quinones 17-25 catechol-O-methyltransferase Homo sapiens 127-131 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-115 16142378-5 2005 In addition, catechol estrogen quinones can be reduced back to catechol estrogens by NADPH quinone oxidoreductase 1 (NQO1) and/or are coupled with glutathione, preventing reaction with DNA. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 117-121 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. Quinones 156-164 synuclein alpha Homo sapiens 86-95 16167833-0 2005 Tyrosinase-catalyzed oxidation of 17beta-estradiol: structure elucidation of the products formed beyond catechol estrogen quinones. Quinones 122-130 tyrosinase Homo sapiens 0-10 16003741-1 2005 NAD(P)H:quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species (ROS). Quinones 116-124 crystallin zeta Homo sapiens 8-30 16003741-1 2005 NAD(P)H:quinone oxidoreductase (NQO1) functions as an important part of cellular antioxidant defense by detoxifying quinones, thus preventing the formation of reactive oxygen species (ROS). Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. Quinones 156-164 synuclein alpha Homo sapiens 211-220 16008565-4 2005 The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts. Quinones 156-164 synuclein alpha Homo sapiens 211-220 19521564-7 2005 Remarkably, the Drosophila grh gene plays an analogous role, regulating enzymes involved in the generation of quinones, which are essential for cross-linking structural components of the fly epidermis. Quinones 110-118 grainy head Drosophila melanogaster 27-30 15665137-1 2005 Structure-based development of NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones resulted in development of RH1 [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone], a methyl-substituted diaziridinyl quinone. Quinones 88-96 NAD(P)H quinone dehydrogenase 1 Homo sapiens 63-67 15746574-2 2005 Previous studies have shown a significant statistical correlation between NQO1 enzymatic activity and the cytotoxicity of certain antitumor quinones. Quinones 140-148 NAD(P)H quinone dehydrogenase 1 Homo sapiens 74-78 15773923-3 2005 Whether tyrosinase is beneficial or detrimental to neurons is unclear; whilst the enzyme activity of tyrosinase generates dopamine-quinones and other oxidizing compounds, NM may form a sink for such radical species. Quinones 131-139 tyrosinase Homo sapiens 101-111 15935811-1 2005 Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress. Quinones 100-108 NAD(P)H dehydrogenase, quinone 1 Mus musculus 25-29 15935811-1 2005 Quinone oxidoreductases (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic reduction of quinones and its derivatives to protect cells against redox cycling and oxidative stress. Quinones 100-108 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 34-38 15884793-12 2005 It is reported that dietary quinones, semiquinones, phenolics, vitamins, amino acids, isoprenoids, and vasoactive compounds can down-regulate the HIF-1 pathways and therefore the expression of several proangiogenic factors. Quinones 28-36 hypoxia inducible factor 1 subunit alpha Homo sapiens 146-151 15733542-7 2005 Among a series of commercially available quinones, a single one was found to be substrate of quinone reductase 2, in the presence of N-benzyldihydronicotinamide: coenzyme Q0. Quinones 41-49 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 93-112 15843167-6 2005 Thus, ERK-dependent downregulation of GJC upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation-independent manner. Quinones 59-67 Eph receptor B1 Rattus norvegicus 6-9 15843167-6 2005 Thus, ERK-dependent downregulation of GJC upon exposure to quinones may occur both by direct phosphorylation of Cx43 and in a phosphorylation-independent manner. Quinones 59-67 gap junction protein, alpha 1 Rattus norvegicus 112-116 15781611-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic protein that catalyzes metabolic detoxification of quinones and protects cells against redox cycling and oxidative stress. Quinones 106-114 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 15781611-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic protein that catalyzes metabolic detoxification of quinones and protects cells against redox cycling and oxidative stress. Quinones 106-114 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 15694256-2 2005 The quinone oxidoreductases, nicotinamide adenine dinucleotide (phosphate) (NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds. Quinones 199-207 NAD(P)H quinone dehydrogenase 1 Homo sapiens 112-116 15386390-6 2004 We tested the hypothesis that young mice deficient in NAD(P)H:quinone oxidoreductase 1 (NQO1), an antioxidant enzyme catalyzing the detoxification of quinones and their derivatives, show increased formation of these oxidative DNA lesions. Quinones 150-158 NAD(P)H dehydrogenase, quinone 1 Mus musculus 54-86 15612812-9 2004 Then, a regenerated catechol moiety of adducts scavenge two additional radicals by reoxidation into quinones, which undergo the second nucleophilic attack at the C-5. Quinones 100-108 complement C5 Homo sapiens 162-165 15618957-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a detoxification enzyme that protects cells against oxidative stress and toxic quinones. Quinones 122-130 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 15618957-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a detoxification enzyme that protects cells against oxidative stress and toxic quinones. Quinones 122-130 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 15940348-1 2005 We aimed to characterize the role of NAD(P)H:quinone oxidoreductase (NQO1) in apoptosis induction by antitumour quinones RH1 (2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone) and MeDZQ (2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone). Quinones 112-120 NAD(P)H dehydrogenase [quinone] 1 Ovis aries 69-73 15386390-6 2004 We tested the hypothesis that young mice deficient in NAD(P)H:quinone oxidoreductase 1 (NQO1), an antioxidant enzyme catalyzing the detoxification of quinones and their derivatives, show increased formation of these oxidative DNA lesions. Quinones 150-158 NAD(P)H dehydrogenase, quinone 1 Mus musculus 88-92 15322212-5 2004 We demonstrate that aromatic and polar DEP fractions, which are enriched in polycyclic aromatic hydrocarbons and quinones, respectively, induce the expression of HO-1, GST, and other phase II enzymes in macrophages and epithelial cells. Quinones 113-121 heme oxygenase 1 Homo sapiens 162-166 15659805-2 2004 Several reports suggest that activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) plays a key role in the disrupted GJIC by hydrogen peroxide, 12-O-tetradecanoylphorbol-13-acetate, and quinones in rat liver epithelial cells. Quinones 210-218 mitogen activated protein kinase 3 Rattus norvegicus 99-105 15544473-8 2004 Other neutral compounds, mainly quinones, were found to inhibit CD45 and Cdc25. Quinones 32-40 protein tyrosine phosphatase, receptor type, C Mus musculus 64-68 15544473-8 2004 Other neutral compounds, mainly quinones, were found to inhibit CD45 and Cdc25. Quinones 32-40 cell division cycle 25C Mus musculus 73-78 15382274-1 2004 BACKGROUND: NAD(P)H:quinone oxidoreductase1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-43 15382274-1 2004 BACKGROUND: NAD(P)H:quinone oxidoreductase1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 45-49 15342368-1 2004 NRH:Quinone oxidoreductase 2 (NQO2) is an enzyme that catalyzes the reductive metabolism of quinones. Quinones 92-100 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 0-28 15342368-1 2004 NRH:Quinone oxidoreductase 2 (NQO2) is an enzyme that catalyzes the reductive metabolism of quinones. Quinones 92-100 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 30-34 15590775-1 2004 Type II NAD(P)H:quinone oxidoreductases (NDH-2) catalyze the two-electron transfer from NAD(P)H to quinones, without any energy-transducing site. Quinones 99-107 NADH-ubiquinone reductase (H(+)-translocating) NDE2 Saccharomyces cerevisiae S288C 41-46 15476858-3 2004 Firstly, the catalytic activity of NQO1 is directed towards the complete reduction and detoxication of highly reactive quinones. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 15554240-2 2004 NQO1 has long been viewed as a chemoprotective enzyme involved in cellular defense against the electrophilic and oxidizing metabolites of xenobiotic quinones. Quinones 149-157 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 17-21 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15554240-8 2004 Polymorphisms in NQO1 which have profound influence on phenotype such as the NQO1*2 polymorphism may influence the chemoprotective actions of NQO1, and should be considered when NQO1-directed antitumor quinones are used for therapy in patients. Quinones 202-210 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15128404-4 2004 We here show that mature neurons in one defined zone selectively express NADPH:quinone oxidoreductase (NQO1), an enzyme that catalyses reduction of quinones. Quinones 148-156 crystallin, zeta Mus musculus 79-101 15245776-1 2004 DT-diaphorase (DTD) is an obligate two-electron reductase which bioactivates chemotherapeutic quinones. Quinones 94-102 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 15240547-1 2004 PURPOSE: NAD(P)H: quinone oxidoreductase (NQO(1)) catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 91-99 crystallin zeta Homo sapiens 19-41 15240547-1 2004 PURPOSE: NAD(P)H: quinone oxidoreductase (NQO(1)) catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 91-99 NAD(P)H quinone dehydrogenase 1 Homo sapiens 43-49 15131056-8 2004 The toxicity of the NQO1-directed antitumor quinones RH1 and streptonigrin were markedly greater and the toxicity of menadione, which is detoxified by NQO1, was ameliorated in the NQ16 line. Quinones 44-52 NAD(P)H quinone dehydrogenase 1 Homo sapiens 20-24 15131056-11 2004 CONCLUSIONS: The MDA468/NQ16 isogenic cell line pair is a useful model system for evaluating the role of NQO1 in the bioactivation of antitumor quinones in both cell lines and xenografts. Quinones 144-152 NAD(P)H quinone dehydrogenase 1 Homo sapiens 105-109 15128404-4 2004 We here show that mature neurons in one defined zone selectively express NADPH:quinone oxidoreductase (NQO1), an enzyme that catalyses reduction of quinones. Quinones 148-156 NAD(P)H dehydrogenase, quinone 1 Mus musculus 103-107 15128404-8 2004 These results indicate that one division of both the accessory and the main olfactory projection maps are composed of sensory neurons that are specialized to reduce environmental and/or endogenously produced quinones via an NQO1-dependent mechanism. Quinones 208-216 NAD(P)H dehydrogenase, quinone 1 Mus musculus 224-228 15089092-0 2004 Characterization and quantitative analysis of DNA adducts formed from lower chlorinated PCB-derived quinones. Quinones 100-108 pyruvate carboxylase Homo sapiens 88-91 15134917-2 2004 In 10% methanol/water, the one-electron reduction of quinones L1 and L2 to the corresponding semiquinones is shifted to more positive potentials upon addition of one equivalent of Zn(II), Ni(II), Co(II) or Cd(II) and is consistent with formation of a 1:1 complex involving the quinone(N) and adjacent quinone(O). Quinones 53-61 mitochondrially encoded cytochrome c oxidase II Homo sapiens 196-202 14991562-1 2004 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes a reductive detoxification that is thought to protect cells against the adverse effects of quinones and related compounds. Quinones 141-149 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 14991562-1 2004 NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes a reductive detoxification that is thought to protect cells against the adverse effects of quinones and related compounds. Quinones 141-149 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 15028260-1 2004 A series of quinolinequinones bearing various substituents has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (hNQO1) was studied. Quinones 21-29 2,4-dienoyl-CoA reductase 1 Homo sapiens 168-175 15028260-1 2004 A series of quinolinequinones bearing various substituents has been synthesized, and the effects of substituents on the metabolism of the quinones by recombinant human NAD(P)H:quinone oxidoreductase (hNQO1) was studied. Quinones 21-29 crystallin zeta Homo sapiens 176-198 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 38-43 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 39-43 15028260-9 2004 Quinones that are good substrates for hNQO1 are more toxic to the NQO1 containing or expressing cell lines (H460 and BE-NQ) than the NQO1 deficient cell lines (H596 and BE-WT). Quinones 0-8 NAD(P)H quinone dehydrogenase 1 Homo sapiens 66-70 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. Quinones 161-169 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 14604985-5 2004 Compared with other related pyridine nucleotide-disulfide oxidoreductases such as glutathione reductase or trypanothione reductase, the k(ca)(t)/K(m) value for quinone reduction by TrxR was about 1 order of magnitude higher, and it was not directly related to the one-electron reduction potential of the quinones. Quinones 304-312 glutathione-disulfide reductase Homo sapiens 82-103 14726156-0 2004 Studies on the DT-diaphorase-catalysed reaction employing quinones as substrates: evidence for a covalent modification of DT-diaphorase by tetrachloro-p-benzoquinone. Quinones 58-66 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 15-28 14726156-0 2004 Studies on the DT-diaphorase-catalysed reaction employing quinones as substrates: evidence for a covalent modification of DT-diaphorase by tetrachloro-p-benzoquinone. Quinones 58-66 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 122-135 14726156-4 2004 Furthermore, tetrachloro-p-benzoquinone, one of the tested quinones is shown to be an inhibitor of rat DT-diaphorase. Quinones 59-67 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 103-116 14675458-8 2003 Quinone reductase is a major enzyme of xenobiotic metabolism that carries out obligatory two-electron reductions and thereby protects cells against toxicity of quinones. Quinones 160-168 crystallin, zeta Mus musculus 0-17 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 mitogen activated protein kinase 3 Rattus norvegicus 45-90 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 mitogen activated protein kinase 1 Rattus norvegicus 95-100 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 epidermal growth factor receptor Rattus norvegicus 123-155 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 epidermal growth factor receptor Rattus norvegicus 157-161 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 mitogen activated protein kinase 3 Rattus norvegicus 167-171 12874275-2 2003 All three quinones induced the activation of extracellular signal-regulated kinase (ERK) 1 and ERK 2 via the activation of epidermal growth factor receptor (EGFR) and MAPK/ERK kinases (MEK) 1/2. Quinones 10-18 mitogen activated protein kinase kinase 1 Rattus norvegicus 172-193 14500388-1 2003 NADPH:quinone oxidoreductase (NQO(1)), a homodimeric, ubiquitous, flavoprotein, catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 120-128 crystallin zeta Homo sapiens 6-28 14500388-1 2003 NADPH:quinone oxidoreductase (NQO(1)), a homodimeric, ubiquitous, flavoprotein, catalyzes the two-electron reduction of quinones to hydroquinones. Quinones 120-128 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-36 14679015-1 2003 The Phase I enzyme cytochrome p450 1B1 (CYP1B1) has been postulated to play a key role in estrogen-induced mammary carcinogenesis by catalyzing the oxidative metabolism of 17beta-estradiol (E(2)) to catechol estrogens (2-OHE(2) and 4-OHE(2)) and highly reactive estrogen quinones (E(2)-2,3-Q and E(2)-3,4-Q). Quinones 271-279 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 14679015-2 2003 The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme. Quinones 21-29 glutathione S-transferase pi 1 Homo sapiens 174-202 14679015-2 2003 The potential of the quinones to induce mutagenic DNA lesions is expected to be decreased by their conjugation with glutathione (GSH) either nonenzymatically or catalyzed by glutathione S-transferase P1 (GSTP1), a Phase II enzyme. Quinones 21-29 glutathione S-transferase pi 1 Homo sapiens 204-209 12859987-4 2003 The reactivity of quinones towards NQO1 did not depend on their E(1)7. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 35-39 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. Quinones 161-169 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. Quinones 161-169 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 12810639-1 2003 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) catalyze the oxidative metabolism of 17 beta-estradiol (E2) to catechol estrogens (2-OHE2 and 4-OHE2) and estrogen quinones, which may lead to DNA damage. Quinones 161-169 dihydrolipoamide branched chain transacylase E2 Homo sapiens 102-104 12834817-1 2003 NAD(P)H: quinone oxidoreductase (NQO1), an obligate two-electron reductase of quinones, prevents their participation in redox cycling and subsequent generation of reactive oxygen species (ROS). Quinones 78-86 crystallin zeta Homo sapiens 9-31 12590585-1 2003 NAD(P)H/quinone acceptor oxidoreductase type 1 (QR1) protects cells from cytotoxic and neoplastic effects of quinones though two-electron reduction. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-46 12834817-1 2003 NAD(P)H: quinone oxidoreductase (NQO1), an obligate two-electron reductase of quinones, prevents their participation in redox cycling and subsequent generation of reactive oxygen species (ROS). Quinones 78-86 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 12663042-3 2003 Two statistically correlated groups of quinones can be discerned: positive-correlated compounds, which are more active in cell lines expressing high baseline levels of BAD protein and NQO1 activity (e.g. the MCF-7 breast carcinoma), and negative-correlated compounds, which are more active in cell lines with undetectable levels of BAD and NQO1 activity (e.g. the HL-60 myeloid leukemia). Quinones 39-47 NAD(P)H quinone dehydrogenase 1 Homo sapiens 184-188 12663042-3 2003 Two statistically correlated groups of quinones can be discerned: positive-correlated compounds, which are more active in cell lines expressing high baseline levels of BAD protein and NQO1 activity (e.g. the MCF-7 breast carcinoma), and negative-correlated compounds, which are more active in cell lines with undetectable levels of BAD and NQO1 activity (e.g. the HL-60 myeloid leukemia). Quinones 39-47 NAD(P)H quinone dehydrogenase 1 Homo sapiens 340-344 12590933-5 2003 Ninety percent of H(2)O(2) generation by both the quinones can be prevented by dicumarol, an inhibitor of NAD(P)H quinone oxidoreductase (NQO1), at the submicromolar level, regardless of the quinone concentrations. Quinones 50-58 crystallin zeta Homo sapiens 114-136 12590933-5 2003 Ninety percent of H(2)O(2) generation by both the quinones can be prevented by dicumarol, an inhibitor of NAD(P)H quinone oxidoreductase (NQO1), at the submicromolar level, regardless of the quinone concentrations. Quinones 50-58 NAD(P)H quinone dehydrogenase 1 Homo sapiens 138-142 12590585-1 2003 NAD(P)H/quinone acceptor oxidoreductase type 1 (QR1) protects cells from cytotoxic and neoplastic effects of quinones though two-electron reduction. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 48-51 12590585-4 2003 The experimental and theoretical studies independently support a model in which quinones (with one to three fused aromatic rings) bind in the QR1 active site utilizing a pi-stacking interaction with the isoalloxazine ring of the FAD cofactor. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Homo sapiens 142-145 12626122-0 2003 Reactive quinones differentially regulate SAPK/JNK and p38/mHOG stress kinases. Quinones 9-17 mitogen-activated protein kinase 9 Homo sapiens 42-46 12626122-0 2003 Reactive quinones differentially regulate SAPK/JNK and p38/mHOG stress kinases. Quinones 9-17 mitogen-activated protein kinase 9 Homo sapiens 47-50 12626122-0 2003 Reactive quinones differentially regulate SAPK/JNK and p38/mHOG stress kinases. Quinones 9-17 mitogen-activated protein kinase 14 Homo sapiens 55-58 12429349-1 2002 NAD(P)H:quinone oxidoreductase 1 (NQO1) has often been suggested to be involved in cancer prevention by means of detoxification of electrophilic quinones. Quinones 145-153 NAD(P)H dehydrogenase [quinone] 1 Cricetulus griseus 0-32 12429349-1 2002 NAD(P)H:quinone oxidoreductase 1 (NQO1) has often been suggested to be involved in cancer prevention by means of detoxification of electrophilic quinones. Quinones 145-153 NAD(P)H dehydrogenase [quinone] 1 Cricetulus griseus 34-38 12351651-1 2002 Dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes the reductive metabolism of quinones. Quinones 127-135 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 0-59 12440719-3 2002 A close parallelism was found between the reactivity of hydroxyanthraquinones and model quinones with single-electron transferring flavoenzymes ferredoxin: NADP+ reductase and NADPH:cytochrome P450 reductase, and their cytotoxicity. Quinones 69-77 ferredoxin reductase Homo sapiens 144-171 12351651-1 2002 Dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) is a flavoenzyme that catalyzes the reductive metabolism of quinones. Quinones 127-135 N-ribosyldihydronicotinamide quinone reductase 2 Mus musculus 61-65 12367526-5 2002 Since cytochrome b and reaction center polypeptides both bind tetrapyrroles and quinones for electron transfer, the observed sequence, functional and structural similarities can best be explained with the assumption of a common evolutionary origin. Quinones 80-88 mitochondrially encoded cytochrome b Homo sapiens 6-18 12269833-6 2002 All three quinones inhibited the catalytic fragment of PKC in vitro, yielding identical IC(50) values (3-5 microM), indicating that they interact with the catalytic domain of PKC rather than the cofactor/activator sites. Quinones 10-18 proline rich transmembrane protein 2 Homo sapiens 55-58 12269833-6 2002 All three quinones inhibited the catalytic fragment of PKC in vitro, yielding identical IC(50) values (3-5 microM), indicating that they interact with the catalytic domain of PKC rather than the cofactor/activator sites. Quinones 10-18 proline rich transmembrane protein 2 Homo sapiens 175-178 12440719-3 2002 A close parallelism was found between the reactivity of hydroxyanthraquinones and model quinones with single-electron transferring flavoenzymes ferredoxin: NADP+ reductase and NADPH:cytochrome P450 reductase, and their cytotoxicity. Quinones 69-77 cytochrome p450 oxidoreductase Homo sapiens 176-207 12147263-0 2002 Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships. Quinones 26-34 crystallin zeta Rattus norvegicus 56-78 12147263-1 2002 Mammalian NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) catalyzes the two-electron reduction of quinones and plays one of the main roles in the bioactivation of quinoidal drugs. Quinones 116-124 crystallin zeta Rattus norvegicus 18-40 12147263-1 2002 Mammalian NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) catalyzes the two-electron reduction of quinones and plays one of the main roles in the bioactivation of quinoidal drugs. Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 42-46 12147263-1 2002 Mammalian NAD(P)H:quinone oxidoreductase (NQO1, DT-diaphorase, EC 1.6.99.2) catalyzes the two-electron reduction of quinones and plays one of the main roles in the bioactivation of quinoidal drugs. Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 48-61 12147263-2 2002 In order to understand the enzyme substrate specificity, we have examined the reactions of rat NQO1 with a number of quinones with available potentials of single-electron (E(1)(7)) reduction and pK(a) of their semiquinones. Quinones 117-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 95-99 12147263-8 2002 The analysis of NQO1 reactions with single-electron acceptors and quinones using an "outer-sphere" electron transfer model points to the possibility of a three-step hydride transfer. Quinones 66-74 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 16-20 12099462-2 2002 Although numerous addition reactions of thiolated alkane and aromatic compounds to quinones have been previously reported, this study indicates that inorganic forms of S(-II) act as nucleophiles and electrophiles in addition reactions to the alpha,beta-conjugated system of the quinone. Quinones 83-91 transcription elongation factor A1 Homo sapiens 168-173 12119003-4 2002 The nNOS reductase shares many characteristics with NADPH-cytochrome P450 reductase (CPR), such as catalyzing the reduction of exogenous electron acceptors such as quinones and nitroarenes. Quinones 164-172 nitric oxide synthase 1 Rattus norvegicus 4-8 12119003-4 2002 The nNOS reductase shares many characteristics with NADPH-cytochrome P450 reductase (CPR), such as catalyzing the reduction of exogenous electron acceptors such as quinones and nitroarenes. Quinones 164-172 cytochrome p450 oxidoreductase Rattus norvegicus 52-83 12119003-4 2002 The nNOS reductase shares many characteristics with NADPH-cytochrome P450 reductase (CPR), such as catalyzing the reduction of exogenous electron acceptors such as quinones and nitroarenes. Quinones 164-172 cytochrome p450 oxidoreductase Rattus norvegicus 85-88 11745147-2 2001 As quinones have been found to catalyze reductive transfers by acting as redox mediators, the application of anthraquinone-2,6-disulfonic acid (AQDS) during continuous anaerobic treatment of the reactive azo dye, Reactive Red 2 (RR2), was evaluated. Quinones 3-11 adenosine deaminase RNA specific B2 (inactive) Homo sapiens 222-227 12036909-1 2002 NAD(P)H:quinone oxidoreductase1 (NQO1) is a cytosolic protein that reduces and detoxifies quinones and their derivatives, thus protecting cells against redox cycling and oxidative stress. Quinones 90-98 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-31 12036909-1 2002 NAD(P)H:quinone oxidoreductase1 (NQO1) is a cytosolic protein that reduces and detoxifies quinones and their derivatives, thus protecting cells against redox cycling and oxidative stress. Quinones 90-98 NAD(P)H dehydrogenase, quinone 1 Mus musculus 33-37 11952335-9 2002 However, by spectral analyses we found that the PCB hydroquinones could be oxidized enzymatically to the quinones, which could then bind GSH. Quinones 57-65 pyruvate carboxylase Homo sapiens 48-51 11952335-13 2002 Hence, the oxidation of PCB hydroquinone metabolites to quinones in cells followed by the binding of quinones to GSH and to protein sulfhydryl groups and the resulting oxidative stress may be important aspects of the toxicity of these compounds. Quinones 56-64 pyruvate carboxylase Homo sapiens 24-27 11952335-13 2002 Hence, the oxidation of PCB hydroquinone metabolites to quinones in cells followed by the binding of quinones to GSH and to protein sulfhydryl groups and the resulting oxidative stress may be important aspects of the toxicity of these compounds. Quinones 101-109 pyruvate carboxylase Homo sapiens 24-27 11901209-9 2002 A potential Cdc25 site of interaction was postulated based on molecular modeling with these quinones. Quinones 92-100 cell division cycle 25C Homo sapiens 12-17 11809856-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage. Quinones 174-182 crystallin zeta Homo sapiens 8-30 11809856-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage. Quinones 174-182 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11809856-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) and dihydronicotinamide riboside:quinone oxidoreductases (NQO2) are cytosolic flavoproteins that catalyze the two-electron reduction of quinones and quinoid compounds to hydroquinones, thereby promoting detoxification and preventing the formation of highly reactive oxygen species, which lead to DNA and cell damage. Quinones 174-182 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 96-100 12052210-3 2002 Small molecular modifications can substantially reduce specificity for DT-diaphorase and under these circumstances the quinones become much less toxic in air but retain their potent cytotoxic effects under hypoxic conditions. Quinones 119-127 NAD(P)H quinone dehydrogenase 1 Homo sapiens 71-84 12049845-5 2002 SOD inhibits Cyt(III)c reduction rates in the presence of these quinones and X/XO in a manner which is also dependent on the quinone half-wave redox potential. Quinones 64-72 superoxide dismutase 1 Homo sapiens 0-3 11863427-3 2002 MP2 optimizations show that, while neutral quinones and an indole molecule prefer a pi-stacked arrangement, semiquinone radical anions prefer a T-stacked conformation with significant N-H...pi hydrogen bonding interactions. Quinones 43-51 tryptase pseudogene 1 Homo sapiens 0-3 11882782-1 2002 NAD(P)H:quinone oxidoreductase (NQO1) catalyzes the two- or four-electron reduction of numerous endogenous and environmental quinones (e.g., the vitamin E alpha-tocopherol quinone, menadione, benzene quinones). Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11852047-0 2002 Quinones in long-lived clk-1 mutants of Caenorhabditis elegans. Quinones 0-8 5-demethoxyubiquinone hydroxylase, mitochondrial Caenorhabditis elegans 23-28 11810042-9 2002 NQO1 results suggest that different quinones (possibly estrogenic quinone metabolites) might affect the histological development of breast tumors. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 11563930-4 2001 Metabolism of the quinones by NQO1 revealed that, in general, compounds with electron-withdrawing groups at the indole 3-position were among the best substrates, and that groups larger than methyl at N-1 are clearly tolerated. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-34 11701227-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) participates in the detoxification of many environmental quinones and related compounds. Quinones 97-105 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11701227-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) participates in the detoxification of many environmental quinones and related compounds. Quinones 97-105 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 glutathione S-transferase mu 1 Homo sapiens 40-68 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 glutathione S-transferase mu 1 Homo sapiens 70-75 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 NAD(P)H quinone dehydrogenase 1 Homo sapiens 78-110 11688992-2 2001 Phase II detoxification enzymes such as glutathione S-transferase M1 (GSTM1), NAD(P)H:quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH):quinone oxidoreductase 2 (NQO2) are important as cellular defenses against catecholamine-derived quinones and the oxidative stress that arises as a consequence of their metabolism. Quinones 254-262 NAD(P)H quinone dehydrogenase 1 Homo sapiens 112-116 11377380-13 2001 These data provide evidence that NQO1 can bioactivate antitumor quinones in this system and suggest that a threshold level of NQO1 activity is required to initiate toxic events. Quinones 64-72 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37 11481389-1 2001 BACKGROUND: The phase II enzyme NAD(P)H :quinone oxidoreductase 1 (NQO1) catalyzes quinone detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones and its precursors. Quinones 204-212 NAD(P)H dehydrogenase, quinone 1 Mus musculus 32-65 11481389-1 2001 BACKGROUND: The phase II enzyme NAD(P)H :quinone oxidoreductase 1 (NQO1) catalyzes quinone detoxification, protecting cells from redox cycling, oxidative stress, mutagenicity, and cytotoxicity induced by quinones and its precursors. Quinones 204-212 NAD(P)H dehydrogenase, quinone 1 Mus musculus 67-71 11587640-0 2001 Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Quinones 117-125 NAD(P)H quinone dehydrogenase 1 Homo sapiens 62-94 11587640-1 2001 BACKGROUND: NAD(P)H:quinone acceptor oxidoreductase (QR1) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 129-137 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 37-51 11587640-1 2001 BACKGROUND: NAD(P)H:quinone acceptor oxidoreductase (QR1) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-56 11587640-3 2001 QR1"s ability to bioactivate quinones and its elevated expression in many human solid tumors makes this protein an excellent target for enzyme-directed drug development. Quinones 29-37 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-3 11487969-4 2001 The halogenated quinones 9 and 21 were arylated with 2,6-di-tertbutylphenol and demethylated or hydrolyzed to the target compounds 3 and 4 which were tested in comparison with the non-anellated 5-LOX inhibitors 1 and 2 for LOX inhibition in activated human granulocytes and for antioxidative activity by the method of Popov with the chemiluminometer Photochem. Quinones 16-24 lysyl oxidase Homo sapiens 196-199 11506041-3 2001 The quinones were also reduced by microsomal NADPH-cytochrome P-450 reductase and the corresponding radicals species were also detected by ESR spectroscopy. Quinones 4-12 cytochrome p450 oxidoreductase Homo sapiens 45-77 11487969-4 2001 The halogenated quinones 9 and 21 were arylated with 2,6-di-tertbutylphenol and demethylated or hydrolyzed to the target compounds 3 and 4 which were tested in comparison with the non-anellated 5-LOX inhibitors 1 and 2 for LOX inhibition in activated human granulocytes and for antioxidative activity by the method of Popov with the chemiluminometer Photochem. Quinones 16-24 lysyl oxidase Homo sapiens 223-226 11309386-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11309386-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that utilizes NAD(P)H as an electron donor, catalyzing the two-electron reduction and detoxification of quinones and their derivatives. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11377380-0 2001 Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-53 11377380-0 2001 Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Quinones 145-153 NAD(P)H quinone dehydrogenase 1 Homo sapiens 55-59 11377380-1 2001 To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived from BE human colon adenocarcinoma cells. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 70-83 11377380-1 2001 To investigate the importance of NAD(P)H:quinone oxidoreductase 1 (or DT-diaphorase; NQO1) in the bioactivation of antitumor quinones, we established a series of stably transfected cell lines derived from BE human colon adenocarcinoma cells. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 85-89 11248224-1 2001 The enzyme DT-diaphorase mediates the two-electron reduction of quinones to hydroquinones. Quinones 64-72 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 11-24 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-42 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 44-48 11340659-1 2001 NAD(P)H:quinone oxidoreductase type 1 (QR1, NQO1, formerly DT-diaphorase; EC 1.6.99.2) is an FAD-containing enzyme that catalyzes the nicotinamide nucleotide-dependent reduction of quinones, quinoneimines, azo dyes, and nitro groups. Quinones 181-189 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-72 11340659-2 2001 Animal cells are protected by QR1 from the toxic and neoplastic effects of quinones and other electrophiles. Quinones 75-83 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-33 11222389-10 2001 Thus, inheritance of NQO1 C609T confers an increased risk of de novo acute leukemia in adults, implicating quinones and related compounds that generate oxidative stress in producing acute leukemia. Quinones 107-115 NAD(P)H quinone dehydrogenase 1 Homo sapiens 21-25 11222389-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11222389-1 2001 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. Quinones 69-77 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11429903-1 2001 N,N"-Dicyanonaphthoquinodiimines fused with a pyrazine ring 1 were prepared from the corresponding quinones 4. Quinones 99-107 ring finger protein 1 Homo sapiens 55-61 11154736-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. Quinones 157-165 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 11156574-6 2001 Nevertheless, L-DOPA and two other substrates, namely, catechol and tyramine did produce nitric oxide from Angeli"s salt in the presence of tyrosinase, suggesting involvement of the respective unstable quinones. Quinones 202-210 tyrosinase Rattus norvegicus 140-150 11154736-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. Quinones 157-165 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 11154737-2 2000 NQO1 is known to catalyse metabolic detoxification of quinones and protect cells from redox cycling, oxidative stress and neoplasia. Quinones 54-62 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 11023538-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. Quinones 135-143 crystallin zeta Homo sapiens 8-30 11085502-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. Quinones 105-113 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 11085502-1 2000 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. Quinones 105-113 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 11023538-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) is a polymorphic enzyme involved in the detoxification of potentially mutagenic and carcinogenic quinones. Quinones 135-143 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11035251-1 2000 An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ability to deplete glutathione, and to produce neoplasia. Quinones 111-119 crystallin, zeta Mus musculus 146-163 10975858-0 2000 Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. Quinones 97-105 heme oxygenase 1 Mus musculus 13-29 10975858-11 2000 Taken together, these data show that HO-1 plays an important role in cytoprotection against redox-active DEP chemicals, including quinones. Quinones 130-138 heme oxygenase 1 Mus musculus 37-41 11035251-1 2000 An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ability to deplete glutathione, and to produce neoplasia. Quinones 111-119 NAD(P)H dehydrogenase, quinone 1 Mus musculus 165-168 11035251-1 2000 An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ability to deplete glutathione, and to produce neoplasia. Quinones 128-136 crystallin, zeta Mus musculus 146-163 11035251-1 2000 An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ability to deplete glutathione, and to produce neoplasia. Quinones 128-136 NAD(P)H dehydrogenase, quinone 1 Mus musculus 165-168 11035252-2 2000 One defense against quinone toxicity is the enzyme NAD(P)H:quinone oxidoreductase type 1 (QR1), which metabolizes quinones by a two-electron reduction mechanism, thus averting production of radicals. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-93 11035252-5 2000 QR2 is also capable of reducing quinones to hydroquinones, but unlike QR1, cannot use NAD(P)H. Quinones 32-40 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 0-3 11035254-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze two-electron reduction and detoxification of quinones and its derivatives. Quinones 153-161 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 11035254-1 2000 NAD(P)H:quinone oxidoreductase (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze two-electron reduction and detoxification of quinones and its derivatives. Quinones 153-161 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 70-74 11035256-1 2000 DT-diaphorase, also referred to as NQO1 or NAD(P)H: quinone acceptor oxidoreductase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. Quinones 148-156 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 10924903-6 2000 These results indicate that the nNOS reductase domain can catalyze a only one-electron reduction of bivalent quinones. Quinones 109-117 nitric oxide synthase 1 Homo sapiens 32-36 10825465-4 2000 In a similar experiment, overexpression of NQO1 significantly protected CHO cells against the cytotoxicity of these quinones. Quinones 116-124 NAD(P)H dehydrogenase [quinone] 1 Cricetulus griseus 43-47 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-44 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-50 10706635-1 2000 NAD(P)H/quinone acceptor oxidoreductase (QR1, NQO1, formerly DT-diaphorase; EC ) protects animal cells from the deleterious and carcinogenic effects of quinones and other electrophiles. Quinones 152-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 61-74 12835099-12 2000 Diaphorase could also be protective against quinones, since this enzyme catalyzes their bielectronic reduction back to catechols, thus preventing the formation of chrome species. Quinones 44-52 dihydrolipoamide dehydrogenase Homo sapiens 0-10 10683249-4 2000 A role of cytosolic NQO1 in protection of cells from oxidative stress, cytotoxicity, and mutagenicity of quinones was established. Quinones 105-113 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 20-24 12835099-14 2000 In contrast to diaphorase, cytochrome P450 reductase should not be considered a protective enzyme, since its monoelectronic reduction of quinones leads to formation of semiquinones, that is, even more noxious than the quinones. Quinones 137-145 dihydrolipoamide dehydrogenase Homo sapiens 15-25 12835099-14 2000 In contrast to diaphorase, cytochrome P450 reductase should not be considered a protective enzyme, since its monoelectronic reduction of quinones leads to formation of semiquinones, that is, even more noxious than the quinones. Quinones 172-180 dihydrolipoamide dehydrogenase Homo sapiens 15-25 10644008-3 1999 The role of DT-diaphorase has been thoroughly investigated in situations when the enzyme is able to reduce exogenous and endogenous quinones, hence protecting the cells against these reactive intermediates. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 12-25 10490507-0 1999 Sonochemistry of quinones in argon-saturated aqueous solutions: enhanced cytochrome c reduction. Quinones 17-25 cytochrome c, somatic Homo sapiens 73-85 10748880-1 1999 AIMS: The two electron reduction of quinones to hydroquinones by NAD(P)H quinone oxidoreductase (NQO1) plays an important role in both activation and detoxification of quinone and similarly reactive compounds. Quinones 36-44 NAD(P)H quinone dehydrogenase 1 Homo sapiens 97-101 10397748-1 1999 NAD(P)H:quinone oxidoreductase (NQO1) converts benzene-derived quinones to less toxic hydroquinones and has been implicated in benzene-associated hematotoxicity. Quinones 63-71 crystallin zeta Homo sapiens 8-30 10463613-6 1999 We assayed, by PCR-RFLP, for a polymorphism in an enzyme that detoxifies quinones, NAD(P)H:quinone oxidoreductase (NQO1), in a series (n = 36) of infant leukemias with MLL rearrangements versus unselected cord blood controls (n = 100). Quinones 73-81 crystallin zeta Homo sapiens 91-113 10463613-6 1999 We assayed, by PCR-RFLP, for a polymorphism in an enzyme that detoxifies quinones, NAD(P)H:quinone oxidoreductase (NQO1), in a series (n = 36) of infant leukemias with MLL rearrangements versus unselected cord blood controls (n = 100). Quinones 73-81 NAD(P)H quinone dehydrogenase 1 Homo sapiens 115-119 10463613-6 1999 We assayed, by PCR-RFLP, for a polymorphism in an enzyme that detoxifies quinones, NAD(P)H:quinone oxidoreductase (NQO1), in a series (n = 36) of infant leukemias with MLL rearrangements versus unselected cord blood controls (n = 100). Quinones 73-81 lysine methyltransferase 2A Homo sapiens 168-171 10462055-0 1999 Cytochrome P450 destruction by quinones: comparison of effects in rat and human liver microsomes. Quinones 31-39 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 10397748-1 1999 NAD(P)H:quinone oxidoreductase (NQO1) converts benzene-derived quinones to less toxic hydroquinones and has been implicated in benzene-associated hematotoxicity. Quinones 63-71 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 10393963-1 1999 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 10393963-1 1999 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a two-electron reductase that detoxifies quinones derived from the oxidation of phenolic metabolites of benzene. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 10714272-2 1999 NQO1 acts to protect against oxidative stress induced by a variety of metabolic situations, including metabolism of quinones and other xenobiotics, by: (i) functioning as a two electron donor to provide a shunt that competes with the formation of reactive oxygen species; (ii) maintaining reduced coenzyme Q; and (iii) regulating the stress activated kinase pathway. Quinones 116-124 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 10368308-8 1999 Alternatively, NQO1 activity may prevent the formation of adducts which result from polymerized products of the quinones. Quinones 112-120 NAD(P)H quinone dehydrogenase 1 Homo sapiens 15-19 10194418-10 1999 In both locations mrp1 contributes to cellular glutathione S-conjugate efflux and protects against oxidative stress-inducing quinones. Quinones 125-133 ATP binding cassette subfamily C member 1 Rattus norvegicus 18-22 18967609-1 1999 A previous study was undertaken to test the reaction of several quinones (p-benzoquinone; 2,5-dichloro and 2,6-dichloro p-benzoquinone; tetrachloro-p-benzoquinone; tetrachloro-o-benzoquinone; 2,5-dichloro-3,6-dihydroxy-p-benzoquinone; benz[a]anthracene-7,12-dione) with bovine serum albumin (BSA). Quinones 64-72 albumin Homo sapiens 277-290 9973208-1 1999 Human dihydrodiol dehydrogenase (DD) isoforms are aldo-keto reductases (AKRs) that activate polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiol proximate carcinogens to reactive and redox-active ortho-quinones. Quinones 220-228 dihydrodiol dehydrogenase Homo sapiens 6-31 9865924-0 1998 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Quinones 84-92 crystallin zeta Homo sapiens 35-57 12671267-4 1999 Peptide conjugates with quinones, epoxyquinones and epoxyquinols which constitute new types of pharmaeophores exhibit submicromolar activity against caspase-3 and show moderate neuroprotective effects on neuronal cells. Quinones 24-32 caspase 3 Homo sapiens 149-158 9865924-0 1998 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 59-63 9865924-9 1998 In comparison to the parental cell line, RH1, MeDZQ, and mitomycin C were significantly more cytotoxic to BE-NQ7 cells (17-, 7-, and 3-fold, respectively), confirming that the presence of NQO1 is sufficient to increase cytotoxicity of these antitumor quinones. Quinones 251-259 NAD(P)H quinone dehydrogenase 1 Homo sapiens 188-192 9865924-0 1998 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Quinones 84-92 NAD(P)H quinone dehydrogenase 1 Homo sapiens 152-156 9781667-10 1998 These data point out the possibility of single-electron transfer steps during obligatory two-electron (hydride) reduction of quinones and nitroaromatics by DT-diaphorase. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 156-169 9822546-4 1998 Metabolism of the quinones by NQO1 revealed that, in general, compounds with electron-withdrawing groups at the indole 3-position were among the best substrates, whereas those with amine groups at the 5-position were poor substrates. Quinones 18-26 NAD(P)H quinone dehydrogenase 1 Homo sapiens 30-34 9738013-1 1998 We have previously reported that antiestrogens stimulate quinone reductase (NAD(P)H:(quinone-acceptor) oxidoreductase (QR or NQO1); EC 1.6.99.2) enzymatic activity, an action that may provide protective effects against the toxicity and mutagenicity caused by quinones. Quinones 259-267 NAD(P)H quinone dehydrogenase 1 Homo sapiens 125-129 9851290-5 1998 The 17beta-hydroxysteroid dehydrogenase (17beta-HSD) of human placenta also catalyzes the redox cycling of these quinones, and cycling is inhibited by SOD. Quinones 113-121 hydroxysteroid 17-beta dehydrogenase 13 Homo sapiens 4-39 9851290-5 1998 The 17beta-hydroxysteroid dehydrogenase (17beta-HSD) of human placenta also catalyzes the redox cycling of these quinones, and cycling is inhibited by SOD. Quinones 113-121 hydroxysteroid 17-beta dehydrogenase 13 Homo sapiens 41-51 9851290-5 1998 The 17beta-hydroxysteroid dehydrogenase (17beta-HSD) of human placenta also catalyzes the redox cycling of these quinones, and cycling is inhibited by SOD. Quinones 113-121 superoxide dismutase 1 Homo sapiens 151-154 9748120-1 1998 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoenzyme that catalyzes the two-electron reduction of quinones and related compounds. Quinones 100-108 crystallin zeta Homo sapiens 8-30 9748120-3 1998 NQO1 can bioactivate antitumor quinones such as mitomycin C, and new quinone-based drugs are currently being developed to target this enzyme in tumors such as NSCLC. Quinones 31-39 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9748120-1 1998 NAD(P)H:quinone oxidoreductase (NQO1) is a flavoenzyme that catalyzes the two-electron reduction of quinones and related compounds. Quinones 100-108 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 9579828-1 1998 DT-diaphorase, a homodimeric flavoenzyme, can provide for a defence mechanism against carcinogenesis mediated by dietary or environmental quinones as well as bioactivate quinone-containing chemotherapeutic drugs. Quinones 138-146 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 9625728-2 1998 The inhibition of citrulline formation from l-arginine by quinones, which exhibit one-electron reduction potentials (E17) ranging between -240 and -100 mV, increased at a more positive one-electron reduction potential, suggesting that quinone appears to act as an electron acceptor for nNOS. Quinones 58-66 nitric oxide synthase 1 Rattus norvegicus 286-290 9625728-7 1998 nNOS effectively reduced the quinones as well as PQ causing a marked decrease in the production of NO from l-arginine, while 1, 4-benzoquinone, 9,10-anthraquinone, mitomycin C, and lapachol, which show negligible inhibitory action on nNOS activity, were poor substrates for the enzyme on reduction. Quinones 29-37 nitric oxide synthase 1 Rattus norvegicus 0-4 9731717-2 1998 NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Quinones 72-80 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9731717-2 1998 NQO1 is involved in the reductive bioactivation of cytotoxic antitumour quinones such as mitomycin C, but also plays a protective role against the carcinogenicity and mutagenicity of quinones, their precursors and metabolites. Quinones 183-191 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-4 9625728-7 1998 nNOS effectively reduced the quinones as well as PQ causing a marked decrease in the production of NO from l-arginine, while 1, 4-benzoquinone, 9,10-anthraquinone, mitomycin C, and lapachol, which show negligible inhibitory action on nNOS activity, were poor substrates for the enzyme on reduction. Quinones 29-37 nitric oxide synthase 1 Rattus norvegicus 234-238 9625728-8 1998 These results indicate that PQ and other quinones used in the present study interact with the NADPH-cytochrome P450 reductase domain on nNOS and thus probably inhibit NO formation by shunting electrons away from the normal catalytic pathway. Quinones 41-49 nitric oxide synthase 1 Rattus norvegicus 136-140 9586815-5 1998 These findings suggest that quinones may lead to a p53-independent and pRb-preventable G2/M arrest and apoptosis, which correlate with p21 induction. Quinones 28-36 tumor protein p53 Homo sapiens 51-54 9516435-1 1998 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress. Quinones 128-136 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-32 9516435-1 1998 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoenzyme that catalyzes two-electron reductive metabolism and detoxification of quinones and their derivatives leading to protection of cells against redox cycling and oxidative stress. Quinones 128-136 NAD(P)H dehydrogenase, quinone 1 Mus musculus 34-38 9586815-0 1998 Anticancer quinones induce pRb-preventable G2/M cell cycle arrest and apoptosis. Quinones 11-19 RB transcriptional corepressor 1 Homo sapiens 27-30 9586815-5 1998 These findings suggest that quinones may lead to a p53-independent and pRb-preventable G2/M arrest and apoptosis, which correlate with p21 induction. Quinones 28-36 RB transcriptional corepressor 1 Homo sapiens 71-74 9586815-5 1998 These findings suggest that quinones may lead to a p53-independent and pRb-preventable G2/M arrest and apoptosis, which correlate with p21 induction. Quinones 28-36 cyclin dependent kinase inhibitor 1A Homo sapiens 135-138 9546049-1 1998 In view of the ubiquitous role of the thioredoxin/thioredoxin reductase (TRX/TR) system in living cells, the interaction of Arabidopsis thaliana NADPH-thioredoxin reductase (EC 1.6.4.5) with quinones, an important class of redox cycling and alkylating xenobiotics, was studied. Quinones 191-199 thioredoxin H-type 1 Arabidopsis thaliana 73-76 9546049-10 1998 In several cases, the kcat of quinone reduction exceeded kcat of TRX reduction, suggesting that quinones intercepted electron flux from TR to TRX. Quinones 96-104 thioredoxin H-type 1 Arabidopsis thaliana 65-68 9546049-10 1998 In several cases, the kcat of quinone reduction exceeded kcat of TRX reduction, suggesting that quinones intercepted electron flux from TR to TRX. Quinones 96-104 thioredoxin H-type 1 Arabidopsis thaliana 142-145 9546049-11 1998 Incubation of reduced TR with alkylating quinones resulted in a rapid loss of TRX-reductase activity, while quinone reduction rate was unchanged. Quinones 41-49 thioredoxin H-type 1 Arabidopsis thaliana 78-81 9530167-0 1998 Quinones increase gamma-glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cells. Quinones 0-8 gamma-glutamyltransferase 1 Rattus norvegicus 18-47 9462835-7 1998 These results indicate that the overexpressed NDI1 worked as a member of the respiratory chain in the host cells, even though E. coli membranes are different from S. cerevisiae inner mitochondrial membranes in terms of quinones and lipid composition. Quinones 219-227 NADH-ubiquinone reductase (H(+)-translocating) NDI1 Saccharomyces cerevisiae S288C 46-50 9528687-1 1998 The enzyme DT-diaphorase catalyses the 2-electron reduction of quinones. Quinones 63-71 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 11-24 9530167-14 1998 Together, the data suggest that quinones upregulate GGT through multiple mechanisms, increased transcription and posttranscriptional modulation, which are apparently mediated through generation of reactive oxygen species and GSH conjugated formation, respectively. Quinones 32-40 gamma-glutamyltransferase 1 Rattus norvegicus 52-55 9050836-0 1997 Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or NMNH (reduced nicotinamide mononucleotide), was isolated from bovine kidney more than 30 years ago [S. Liao, J. T. Dulaney and H. G. Williams-Ashman (1962) J. Biol. Quinones 200-208 crystallin zeta Homo sapiens 83-108 21639368-1 1997 The continuous on-line monitoring of endogenous quinones has been realized for the first time in an animal model of brain ischemia induced by a vasoconstrictor peptide, endothelin-1. Quinones 48-56 endothelin 1 Rattus norvegicus 169-181 27406966-7 1997 The results of the present experiments indicate that the relative stability of naphthohydroquinones cannot be judged on the basis of studies involving reduction of the quinone by DT-diaphorase and suggest that current concepts on the role of this enzyme in the detoxification of quinones may need revision. Quinones 91-99 NAD(P)H quinone dehydrogenase 1 Homo sapiens 179-192 9164836-5 1997 Glutathione conjugation of these quinones is a detoxication reaction that prevents redox cycling, thus indicating that GSTs have a cytoprotective role involving elimination of reactive chemical species originating from the oxidative metabolism of catecholamines. Quinones 33-41 hematopoietic prostaglandin D synthase Homo sapiens 119-123 9177041-2 1997 There is strong evidence that CDH reduces quinones, phenoxy and cation radicals. Quinones 42-50 choline dehydrogenase Homo sapiens 30-33 9343369-3 1997 These data indicate that the poor reactivity of nitrobenzimidazoles and other nitroaromatics in comparison to quinones could be determined by their binding in the adenosine-phosphate binding region of the NADPH-binding site, whereas quinones bind at the nicotinamide-binding pocket at the vicinity of FAD of DT-diaphorase. Quinones 110-118 NAD(P)H quinone dehydrogenase 1 Homo sapiens 308-321 9050836-0 1997 Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or NMNH (reduced nicotinamide mononucleotide), was isolated from bovine kidney more than 30 years ago [S. Liao, J. T. Dulaney and H. G. Williams-Ashman (1962) J. Biol. Quinones 200-208 NAD(P)H quinone dehydrogenase 1 Homo sapiens 110-123 9406243-1 1997 DT-diaphorase (EC 1.6.99.2) is a flavoprotein that catalyses two-electron reduction of quinones, quinone imines, and nitrogen oxides. Quinones 87-95 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 23889067-9 1997 It is also possible that cellular generation of superoxide (as might be expected on redox cycling of endogenous quinones following inhibition of DT diaphorase by dicoumarol) may be another source of MTT reduction. Quinones 112-120 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 145-158 9000600-1 1997 NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. Quinones 129-137 crystallin zeta Homo sapiens 8-30 9000600-1 1997 NAD(P)H:quinone oxidoreductase (NQO1, EC 1.6.99.2) is an obligate two-electron reductase that can either bioactivate or detoxify quinones and has been proposed to play an important role in chemoprevention. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 32-36 9054588-3 1997 To our knowledge it has not yet been demonstrated that the natural quinones, vitamin K1 and K2, exert the same activity. Quinones 67-75 keratin 1 Homo sapiens 85-94 8999809-1 1997 DT-diaphorase (EC 1.6.99.2), also referred to as NAD(P)H:(quinone-acceptor) oxidoreductase, is involved in the reductive activation process of several cytotoxic antitumor quinones and nitrobenzenes. Quinones 171-179 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 8999809-1 1997 DT-diaphorase (EC 1.6.99.2), also referred to as NAD(P)H:(quinone-acceptor) oxidoreductase, is involved in the reductive activation process of several cytotoxic antitumor quinones and nitrobenzenes. Quinones 171-179 thioredoxin reductase 1 Homo sapiens 76-90 8971136-0 1996 Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines. Quinones 144-152 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 79-98 8943236-13 1996 p21 induction elicited by the above quinones was inhibited by N-acetylcysteine, whereas the non-sulfur analog, N-acetylalanine, was without effect. Quinones 36-44 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 9118890-4 1996 Peroxidases metabolize hydroquinone to the reactive 1,4-benzoquinone, whereas NQO1 reduces the quinones formed, resulting in detoxification. Quinones 95-103 NAD(P)H quinone dehydrogenase 1 Homo sapiens 78-82 8863816-0 1996 Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Quinones 136-144 crystallin zeta Homo sapiens 29-51 9118895-12 1996 Thus, the data indicate that the quinones destroyed CYP directly and not via oxygen activation or lipid peroxidation. Quinones 33-41 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 52-55 8863816-0 1996 Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Quinones 136-144 NAD(P)H quinone dehydrogenase 1 Homo sapiens 53-66 8763840-12 1996 This suggests that DT-diaphorase detoxified group III quinones and that cytotoxicity may involve DNA oxidative damage by the semiquinone radicals. Quinones 54-62 NAD(P)H dehydrogenase, quinone 1 Mus musculus 19-32 12226388-11 1996 As in the case with DT-diaphorase in animals, the main NAD(P)H-QR function in plant cells may be the reduction of quinones to quinols, which prevents the production of semiquinones and oxygen radicals. Quinones 114-122 NAD(P)H quinone dehydrogenase 1 Homo sapiens 20-33 8678904-5 1996 Since the activity of DT-diaphorase has been associated with sensitivity to quinones, we studied the cytotoxicity of mitomycin C under oxic conditions. Quinones 76-84 NAD(P)H quinone dehydrogenase 1 Homo sapiens 22-35 8620484-1 1996 The two-electron bioreductive enzyme DT-diaphorase catalyzes the metabolism of quinones. Quinones 79-87 NAD(P)H quinone dehydrogenase 1 Homo sapiens 37-50 8657209-1 1996 The influence of the quinone-reducing enzyme, DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase], on the genotoxicity of quinones was examined in two cell lines, namely a human hepatoma cell line, HepG2 and a brown bullhead fibroblast cell line, BB. Quinones 129-137 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-59 8657209-1 1996 The influence of the quinone-reducing enzyme, DT diaphorase [NAD(P)H: (quinone acceptor) oxidoreductase], on the genotoxicity of quinones was examined in two cell lines, namely a human hepatoma cell line, HepG2 and a brown bullhead fibroblast cell line, BB. Quinones 129-137 thioredoxin reductase 1 Homo sapiens 89-104 8653808-1 1996 DT-diaphorase (DTD) activity has been related to bioactivation and cytotoxicity of antitumor quinones. Quinones 93-101 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-13 7677784-1 1995 It is generally accepted that DT-diaphorase is primarily involved in the detoxification of quinone compounds and is capable of metabolically activating some cancer chemotherapeutic quinones including mitomycin C. Quinones 181-189 NAD(P)H dehydrogenase, quinone 1 Mus musculus 30-43 8602872-1 1996 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 8602872-1 1996 NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes two-electron reduction and detoxification of quinones. Quinones 118-126 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 8620581-9 1996 Indications were found that human GST P1-1 may be inhibited via three mechanisms: in addition to the well documentated nucleophilic addition of quinones and oxidation of cysteine residues, a covalent subunit cross-linking was also observed. Quinones 144-152 glutathione S-transferase pi 1 Homo sapiens 34-42 7568029-1 1995 Quinone reductase [NAD(P)H:(quinone acceptor) oxidoreductase, EC 1.6.99.2], also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependent two-electron reductions of quinones and protects cells against the toxic and neoplastic effects of free radicals and reactive oxygen species arising from one-electron reductions. Quinones 213-221 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 88-101 8615688-1 1996 The human placental 17beta-hydroxysteroid dehydrogenase reduces a number of polycyclic aromatic hydrocarbon (PAH) o-quinones; some of the quinones undergo redox cycling at rates that approach or exceed the rate of reduction of estrone by the enzyme. Quinones 116-124 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 10-55 8987252-2 1996 Peroxidase-mediated activation of phenolic metabolites of benzene generates reactive quinones which can be detoxified by NAD(P)H:quinone acceptor oxidoreductase (NQO1). Quinones 85-93 NAD(P)H quinone dehydrogenase 1 Homo sapiens 162-166 8536688-10 1995 It is proposed that NAD(P)H-QR by scavenging unreduced quinones and making them prone to conjugation may act in plant tissues as a functional equivalent of DT-diaphorase. Quinones 55-63 NAD(P)H quinone dehydrogenase 1 Homo sapiens 156-169 7488245-2 1995 DT-diaphorase is a two-electron reducing enzyme that is induced by a variety of chemicals, including quinones. Quinones 101-109 NAD(P)H dehydrogenase, quinone 1 Mus musculus 0-13 9101243-2 1995 A semiquinone species was observed by direct ESR in aerobic conditions during: (a) NADPH-cytochrome P450 reductase-catalyzed reduction of the above quinones. Quinones 148-156 cytochrome p450 oxidoreductase Homo sapiens 83-114 7746280-1 1995 NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. Quinones 162-170 crystallin, zeta Mus musculus 40-57 7746280-1 1995 NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. Quinones 162-170 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 60-73 7565631-0 1995 Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Quinones 125-133 crystallin zeta Homo sapiens 47-69 7565631-0 1995 Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Quinones 125-133 NAD(P)H quinone dehydrogenase 1 Homo sapiens 71-84 7482548-3 1995 The model suggests that oxidation of estradiol to DNA reactive quinones or semiquinones by CYP1A2 protein induced by TCDD may contribute to an increased mutational rate. Quinones 63-71 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 91-97 7639539-1 1995 NAD(P)H: quinone-acceptor oxidoreductase (EC 1.6.99.2), also referred to as DT-diaphorase, is a flavoprotein that catalyzes the two-electron reduction of quinones and quinonoid compounds to hydroquinones, using either NADH or NADPH as the electron donor. Quinones 154-162 NAD(P)H quinone dehydrogenase 1 Homo sapiens 76-89 7626118-3 1995 Consequently, some of the observed inhibition of tyrosinase by azide can be explained by the reaction of enzymatically generated quinones with azide to form azido catechol. Quinones 129-137 tyrosinase Homo sapiens 49-59 7819227-6 1995 Furthermore, we show that the induction of AP-1 binding activity and GST Ya gene expression by these quinones correlates with their oxygen radical production, adriamycin and Qcb being stronger inducers that Qn. Quinones 101-109 glutathione S-transferase kappa 1 Homo sapiens 69-72 7531691-1 1995 NAD(P)H:quinone oxidoreductase (EC 1.6.99.2) (DT-diaphorase) is an FAD-containing enzyme that catalyzes the 2-electron reduction of quinones to hydroquinones using either NADH or NADPH as the electron donor. Quinones 132-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 46-59 7531691-11 1995 The enzyme reconstituted with oxidized 5-deaza-FAD has significant catalytic activity, confirming that DT-diaphorase is an obligatory 2-electron transfer enzyme and plays a role in the detoxification of quinones and quinoid compounds by reducing them to the relatively stable hydroquinones. Quinones 203-211 NAD(P)H quinone dehydrogenase 1 Homo sapiens 103-116 8024324-6 1994 Apparently, for these two quinones the predominant metabolic pathway in both the BF-2 and HepG2 cells involved redox cycling via a one-electron reduction reaction, generating reactive oxygen intermediates that consumed intracellular glutathione. Quinones 26-34 forkhead box G1 Homo sapiens 81-85 20692961-0 1994 Effect of alkylating and redox cycling quinones on insulin receptor autophosphorylation. Quinones 39-47 insulin receptor Homo sapiens 51-67 20692961-3 1994 Since the toxicity of quinones can be related to two mechanisms-redox cycling resulting in oxidative stress, and arylation of cellular nucleophilic groups-the effects of 1,4-naphthoquinone and menadione on insulin receptor autophosphorylation were investigated. Quinones 22-30 insulin receptor Homo sapiens 206-222 20692961-4 1994 The results show that these two quinones have a dual effect: lower concentrations leading to oxidative stress increase insulin receptor autophosphorylation, whereas higher concentrations cause a thiol depletion and inhibit the normal insulin receptor autophosphorylation. Quinones 32-40 insulin receptor Homo sapiens 119-135 20692961-4 1994 The results show that these two quinones have a dual effect: lower concentrations leading to oxidative stress increase insulin receptor autophosphorylation, whereas higher concentrations cause a thiol depletion and inhibit the normal insulin receptor autophosphorylation. Quinones 32-40 insulin receptor Homo sapiens 234-250 8033096-1 1994 NAD(P)H:quinone acceptor oxidoreductase (NQO1, EC 1.6.99.2) is an enzyme that is believed to play a central role in the bioreductive activation of several compounds, particularly quinones. Quinones 179-187 thioredoxin reductase 1 Homo sapiens 25-39 8033096-1 1994 NAD(P)H:quinone acceptor oxidoreductase (NQO1, EC 1.6.99.2) is an enzyme that is believed to play a central role in the bioreductive activation of several compounds, particularly quinones. Quinones 179-187 NAD(P)H quinone dehydrogenase 1 Homo sapiens 41-45 8152225-1 1994 DT diaphorase is a flavoprotein that enzymatically transfers two electrons from quinones as intermediate substrates and has been reported to increase its activity in the liver after exposure to toxicants. Quinones 80-88 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-13 8031317-6 1994 (3) Low concentrations of quinones are capable of protecting CYP against reactive oxygen species produced in the CYP futile cycle. Quinones 26-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 61-64 8031317-6 1994 (3) Low concentrations of quinones are capable of protecting CYP against reactive oxygen species produced in the CYP futile cycle. Quinones 26-34 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 113-116 8031317-7 1994 (4) Ascorbate effectively protects CYP against quinones, apparently by maintaining them in the reduced state. Quinones 47-55 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 35-38 8031317-8 1994 (5) Quinones attack both heme and protein of CYP. Quinones 4-12 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 45-48 8031317-10 1994 In conclusion, we suggest that quinones may be responsible for CYP destruction by benzene in vivo. Quinones 31-39 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 63-66 8114670-11 1994 The results provide direct evidence of the existence and functional role of hyperreactive cysteine residues on the RyR and triadin in regulating the gating of ryanodine-sensitive intracellular Ca2+ channels and strongly suggest that these important Ca2+ regulatory channels may be an important target for oxidative cell damage mediated by quinones. Quinones 339-347 ryanodine receptor 1 Homo sapiens 115-118 8004128-1 1994 NAD(P)H:Quinone oxidoreductase1 (NQO1) is a flavoprotein which promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress and neoplasia. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-31 8004128-1 1994 NAD(P)H:Quinone oxidoreductase1 (NQO1) is a flavoprotein which promotes obligatory two-electron reduction of quinones, preventing their participation in redox cycling, oxidative stress and neoplasia. Quinones 109-117 NAD(P)H quinone dehydrogenase 1 Homo sapiens 33-37