PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34285153-7 2021 This elevation of DH Piezo2-IR was also evident in various neuropathic pain models and monosodium iodoacetate knee osteoarthritis pain model, compared with controls. monosodium iodoacetate 87-109 piezo-type mechanosensitive ion channel component 2 Rattus norvegicus 21-27 34572070-8 2021 PTX-3 silencing in SMUP-Cells significantly decreased their therapeutic effects against monosodium iodoacetate (MIA)-induced OA. monosodium iodoacetate 88-110 pentraxin 3 Rattus norvegicus 0-5 34362382-0 2021 Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression. monosodium iodoacetate 36-58 aldehyde dehydrogenase 2 family member Homo sapiens 0-24 34362382-0 2021 Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression. monosodium iodoacetate 36-58 aquaporin 4 Homo sapiens 143-154 25837919-6 2015 By contrast, mechanical allodynia in the monosodium iodoacetate-induced osteoarthritis pain model and the experimental autoimmune encephalomyelitis model were significantly attenuated in TRPM2-knockout mice. monosodium iodoacetate 41-63 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 187-192 32570114-1 2020 This study built an OA model in rats by monosodium iodoacetate (MIA) injection to determine the effects and mechanism of the voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)-calcitonin gene-related protein (CGRP) pathway in osteoarthritis (OA)-induced ongoing pain. monosodium iodoacetate 40-62 calcium voltage-gated channel auxiliary subunit alpha2delta 1 Rattus norvegicus 184-192 32431699-4 2020 Here, we investigated the role of IL-17 in the pathogenesis of OA using monosodium iodoacetate (MIA)-injected IL-17 and IL-1 receptor antagonist (IL-1Ra) double-deficient mice. monosodium iodoacetate 72-94 interleukin 17A Mus musculus 110-115 31152077-6 2019 Nicotine treatment reduced mechanical allodynia, cartilage degradation, and the upregulation of matrix metalloproteinase-9 (MMP-9), a hallmark of joint inflammation in OA, in mice treated with monosodium iodoacetate. monosodium iodoacetate 193-215 matrix metallopeptidase 9 Mus musculus 96-122 31152077-6 2019 Nicotine treatment reduced mechanical allodynia, cartilage degradation, and the upregulation of matrix metalloproteinase-9 (MMP-9), a hallmark of joint inflammation in OA, in mice treated with monosodium iodoacetate. monosodium iodoacetate 193-215 matrix metallopeptidase 9 Mus musculus 124-129 30619261-0 2018 The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. monosodium iodoacetate 114-136 signal transducer and activator of transcription 3 Rattus norvegicus 26-31 30542428-0 2018 TNF-alpha increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 136-158 tumor necrosis factor Rattus norvegicus 0-9 30542428-0 2018 TNF-alpha increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 136-158 AKT serine/threonine kinase 1 Rattus norvegicus 106-109 29740093-3 2018 Male Sprague-Dawley rats received unilateral intra-articular injections of monosodium iodoacetate (MIA 1 mg) or saline, and weight-bearing (WB) asymmetry and distal allodynia measured. monosodium iodoacetate 75-97 MIA SH3 domain containing Rattus norvegicus 99-104 28663035-3 2017 The present study aims to elucidate the IL-6 mediated neurological adaptation in dorsal horn in the rat with monosodium iodoacetate (MIA) - induced OA. monosodium iodoacetate 109-131 interleukin 6 Rattus norvegicus 40-44 28442110-0 2017 Ethanolic extracts of babandotan leaves (Ageratum conyzoides L.) prevents inflammation and proteoglycan degradation by inhibiting TNF-alpha and MMP-9 on osteoarthritis rats induced by monosodium iodoacetate. monosodium iodoacetate 184-206 matrix metallopeptidase 9 Rattus norvegicus 144-149 27068285-3 2016 RESULTS: Four to five weeks post intra-articular injection of monosodium iodoacetate (MIA, 1 mg) into the left knee, Sprague Dawley rats were anesthetized for functional magnetic resonance imaging studies to characterize the neural response to a noxious stimulus (intra-articular capsaicin injection). monosodium iodoacetate 62-84 MIA SH3 domain containing Rattus norvegicus 86-92 26521748-0 2015 Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. monosodium iodoacetate 0-22 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 74-79 26521748-0 2015 Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. monosodium iodoacetate 0-22 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 114-119 35385163-0 2022 Chondroprotection of fruit peels in a monosodium iodoacetate-induced osteoarthritis rat model via downregulation of Col1A1. monosodium iodoacetate 38-60 collagen type I alpha 1 chain Rattus norvegicus 116-122 32640182-0 2020 In vivo protective effects of UCMA against cartilage degeneration in monosodium iodoacetate-induced osteoarthritis model. monosodium iodoacetate 69-91 upper zone of growth plate and cartilage matrix associated Homo sapiens 30-34 32640182-6 2020 We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in monosodium iodoacetate-induced OA rat model. monosodium iodoacetate 103-125 upper zone of growth plate and cartilage matrix associated Rattus norvegicus 50-54 31130863-4 2019 Monosodium iodoacetate (MIA) was injected into the knee of Swiss-albino CD1 mice to induce osteoarthritis pain, which then received a repeated treatment with the sigma1R antagonist E-52862 or its vehicle. monosodium iodoacetate 0-22 CD1 antigen complex Mus musculus 72-75 31130863-4 2019 Monosodium iodoacetate (MIA) was injected into the knee of Swiss-albino CD1 mice to induce osteoarthritis pain, which then received a repeated treatment with the sigma1R antagonist E-52862 or its vehicle. monosodium iodoacetate 0-22 sigma non-opioid intracellular receptor 1 Mus musculus 162-169 29693122-15 2018 In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 274-296 tumor necrosis factor Mus musculus 61-70 29693122-15 2018 In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 274-296 tumor necrosis factor Mus musculus 169-178 29693122-15 2018 In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 274-296 toll-like receptor 3 Mus musculus 213-218 29693122-15 2018 In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis. monosodium iodoacetate 274-296 mitogen-activated protein kinase 1 Mus musculus 228-231 28535500-10 2017 RESULTS: We constructed a monosodium iodoacetate (MIA) -induced rat OA model and found that ruthenium red (TRPV5 inhibitor) slowed the progression of joint destruction. monosodium iodoacetate 26-48 transient receptor potential cation channel, subfamily V, member 5 Rattus norvegicus 107-112 23891968-2 2013 monosodium iodoacetate (MIA, 1 mg/25 microl) in the rat right knee while the left knee received saline (25 microl). monosodium iodoacetate 0-22 MIA SH3 domain containing Rattus norvegicus 24-30 24204985-0 2013 The inhibition of subchondral bone lesions significantly reversed the weight-bearing deficit and the overexpression of CGRP in DRG neurons, GFAP and Iba-1 in the spinal dorsal horn in the monosodium iodoacetate induced model of osteoarthritis pain. monosodium iodoacetate 188-210 calcitonin-related polypeptide alpha Rattus norvegicus 119-123 23287799-0 2013 Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. monosodium iodoacetate 48-70 nitric oxide synthase 2 Rattus norvegicus 10-14 20633676-2 2010 METHODS: Monosodium iodoacetate (MIA), a metabolic inhibitor, was injected into the right knee joint of male Lewis rats and the release of aggrecanase-cleaved fragments of aggrecan containing the NITEGE or ARGN neoepitope was measured in the synovial fluid at 7 days post MIA injection using novel ELISAs. monosodium iodoacetate 9-31 ADAM metallopeptidase with thrombospondin type 1 motif, 4 Rattus norvegicus 139-150 17284318-5 2007 The most frequently used rat model for analyzing properties of drugs on the pathology of osteoarthritis is the injection of the metabolic inhibitor monosodium iodoacetate into the joint, which inhibits the activity of glyceraldehyde-3-phosphate dehydrogenase in chondrocytes. monosodium iodoacetate 148-170 glyceraldehyde-3-phosphate dehydrogenase Rattus norvegicus 218-258 23199705-0 2013 Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. monosodium iodoacetate 86-108 cannabinoid receptor 1 (brain) Mus musculus 8-11 23199705-0 2013 Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate. monosodium iodoacetate 86-108 cannabinoid receptor 2 (macrophage) Mus musculus 16-19