PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34285153-7	2021	This elevation of DH Piezo2-IR was also evident in various neuropathic pain models and monosodium iodoacetate knee osteoarthritis pain model, compared with controls.	monosodium iodoacetate	87-109	piezo-type mechanosensitive ion channel component 2	Rattus norvegicus	21-27
31152077-6	2019	Nicotine treatment reduced mechanical allodynia, cartilage degradation, and the upregulation of matrix metalloproteinase-9 (MMP-9), a hallmark of joint inflammation in OA, in mice treated with monosodium iodoacetate.	monosodium iodoacetate	193-215	matrix metallopeptidase 9	Mus musculus	96-122
32640182-0	2020	In vivo protective effects of UCMA against cartilage degeneration in monosodium iodoacetate-induced osteoarthritis model.	monosodium iodoacetate	69-91	upper zone of growth plate and cartilage matrix associated	Homo sapiens	30-34
32640182-6	2020	We report for the first time that intra-articular UCMA injection ameliorated cartilage degeneration in monosodium iodoacetate-induced OA rat model.	monosodium iodoacetate	103-125	upper zone of growth plate and cartilage matrix associated	Rattus norvegicus	50-54
32431699-4	2020	Here, we investigated the role of IL-17 in the pathogenesis of OA using monosodium iodoacetate (MIA)-injected IL-17 and IL-1 receptor antagonist (IL-1Ra) double-deficient mice.	monosodium iodoacetate	72-94	interleukin 17A	Mus musculus	110-115
34572070-8	2021	PTX-3 silencing in SMUP-Cells significantly decreased their therapeutic effects against monosodium iodoacetate (MIA)-induced OA.	monosodium iodoacetate	88-110	pentraxin 3	Rattus norvegicus	0-5
34362382-0	2021	Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression.	monosodium iodoacetate	36-58	aldehyde dehydrogenase 2 family member	Homo sapiens	0-24
34362382-0	2021	Aldehyde dehydrogenase 2 alleviates monosodium iodoacetate-induced oxidative stress, inflammation and apoptosis in chondrocytes via inhibiting aquaporin 4 expression.	monosodium iodoacetate	36-58	aquaporin 4	Homo sapiens	143-154
35385163-0	2022	Chondroprotection of fruit peels in a monosodium iodoacetate-induced osteoarthritis rat model via downregulation of Col1A1.	monosodium iodoacetate	38-60	collagen type I alpha 1 chain	Rattus norvegicus	116-122
32570114-1	2020	This study built an OA model in rats by monosodium iodoacetate (MIA) injection to determine the effects and mechanism of the voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)-calcitonin gene-related protein (CGRP) pathway in osteoarthritis (OA)-induced ongoing pain.	monosodium iodoacetate	40-62	calcium voltage-gated channel auxiliary subunit alpha2delta 1	Rattus norvegicus	184-192
31152077-6	2019	Nicotine treatment reduced mechanical allodynia, cartilage degradation, and the upregulation of matrix metalloproteinase-9 (MMP-9), a hallmark of joint inflammation in OA, in mice treated with monosodium iodoacetate.	monosodium iodoacetate	193-215	matrix metallopeptidase 9	Mus musculus	124-129
28663035-3	2017	The present study aims to elucidate the IL-6 mediated neurological adaptation in dorsal horn in the rat with monosodium iodoacetate (MIA) - induced OA.	monosodium iodoacetate	109-131	interleukin 6	Rattus norvegicus	40-44
30542428-0	2018	TNF-alpha increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	136-158	tumor necrosis factor	Rattus norvegicus	0-9
30542428-0	2018	TNF-alpha increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	136-158	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
29693122-15	2018	In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	274-296	tumor necrosis factor	Mus musculus	61-70
29693122-15	2018	In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	274-296	tumor necrosis factor	Mus musculus	169-178
29693122-15	2018	In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	274-296	toll-like receptor 3	Mus musculus	213-218
29693122-15	2018	In conclusion the results of the present study indicate that TNF-alpha serves an essential role in synovial fibroblasts in osteoarthritis, suggesting that inhibition of TNF-alpha may decrease inflammation via the TLR-3-mediated ERK/AKT signaling pathway in a mouse model of monosodium iodoacetate-induced osteoarthritis.	monosodium iodoacetate	274-296	mitogen-activated protein kinase 1	Mus musculus	228-231
29740093-3	2018	Male Sprague-Dawley rats received unilateral intra-articular injections of monosodium iodoacetate (MIA 1 mg) or saline, and weight-bearing (WB) asymmetry and distal allodynia measured.	monosodium iodoacetate	75-97	MIA SH3 domain containing	Rattus norvegicus	99-104
31130863-4	2019	Monosodium iodoacetate (MIA) was injected into the knee of Swiss-albino CD1 mice to induce osteoarthritis pain, which then received a repeated treatment with the sigma1R antagonist E-52862 or its vehicle.	monosodium iodoacetate	0-22	CD1 antigen complex	Mus musculus	72-75
31130863-4	2019	Monosodium iodoacetate (MIA) was injected into the knee of Swiss-albino CD1 mice to induce osteoarthritis pain, which then received a repeated treatment with the sigma1R antagonist E-52862 or its vehicle.	monosodium iodoacetate	0-22	sigma non-opioid intracellular receptor 1	Mus musculus	162-169
30619261-0	2018	The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis.	monosodium iodoacetate	114-136	signal transducer and activator of transcription 3	Rattus norvegicus	26-31
28442110-0	2017	Ethanolic extracts of babandotan leaves (Ageratum conyzoides L.) prevents inflammation and proteoglycan degradation by inhibiting TNF-alpha and MMP-9 on osteoarthritis rats induced by monosodium iodoacetate.	monosodium iodoacetate	184-206	matrix metallopeptidase 9	Rattus norvegicus	144-149
26521748-0	2015	Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.	monosodium iodoacetate	0-22	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
28535500-10	2017	RESULTS: We constructed a monosodium iodoacetate (MIA) -induced rat OA model and found that ruthenium red (TRPV5 inhibitor) slowed the progression of joint destruction.	monosodium iodoacetate	26-48	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	107-112
27068285-3	2016	RESULTS: Four to five weeks post intra-articular injection of monosodium iodoacetate (MIA, 1 mg) into the left knee, Sprague Dawley rats were anesthetized for functional magnetic resonance imaging studies to characterize the neural response to a noxious stimulus (intra-articular capsaicin injection).	monosodium iodoacetate	62-84	MIA SH3 domain containing	Rattus norvegicus	86-92
26521748-0	2015	Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.	monosodium iodoacetate	0-22	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	114-119
23891968-2	2013	monosodium iodoacetate (MIA, 1 mg/25 microl) in the rat right knee while the left knee received saline (25 microl).	monosodium iodoacetate	0-22	MIA SH3 domain containing	Rattus norvegicus	24-30
25837919-6	2015	By contrast, mechanical allodynia in the monosodium iodoacetate-induced osteoarthritis pain model and the experimental autoimmune encephalomyelitis model were significantly attenuated in TRPM2-knockout mice.	monosodium iodoacetate	41-63	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	187-192
24204985-0	2013	The inhibition of subchondral bone lesions significantly reversed the weight-bearing deficit and the overexpression of CGRP in DRG neurons, GFAP and Iba-1 in the spinal dorsal horn in the monosodium iodoacetate induced model of osteoarthritis pain.	monosodium iodoacetate	188-210	calcitonin-related polypeptide alpha	Rattus norvegicus	119-123
23199705-0	2013	Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.	monosodium iodoacetate	86-108	cannabinoid receptor 1 (brain)	Mus musculus	8-11
23287799-0	2013	Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy.	monosodium iodoacetate	48-70	nitric oxide synthase 2	Rattus norvegicus	10-14
23199705-0	2013	Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate.	monosodium iodoacetate	86-108	cannabinoid receptor 2 (macrophage)	Mus musculus	16-19
17284318-5	2007	The most frequently used rat model for analyzing properties of drugs on the pathology of osteoarthritis is the injection of the metabolic inhibitor monosodium iodoacetate into the joint, which inhibits the activity of glyceraldehyde-3-phosphate dehydrogenase in chondrocytes.	monosodium iodoacetate	148-170	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	218-258
20633676-2	2010	METHODS: Monosodium iodoacetate (MIA), a metabolic inhibitor, was injected into the right knee joint of male Lewis rats and the release of aggrecanase-cleaved fragments of aggrecan containing the NITEGE or ARGN neoepitope was measured in the synovial fluid at 7 days post MIA injection using novel ELISAs.	monosodium iodoacetate	9-31	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	139-150