PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33467081-2	2021	Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).	4-aminobenzhydrazide	110-139	myeloperoxidase	Equus caballus	0-15
33467081-2	2021	Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).	4-aminobenzhydrazide	110-139	myeloperoxidase	Equus caballus	17-20
33467081-2	2021	Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).	4-aminobenzhydrazide	141-145	myeloperoxidase	Equus caballus	0-15
33467081-2	2021	Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).	4-aminobenzhydrazide	141-145	myeloperoxidase	Equus caballus	17-20
33467081-5	2021	Explants retrieved from the endometrium of mares in follicular or mid-luteal phases were treated with MPO, ABAH, or their combination, for 24 or 48 h. The qPCR analysis measured the transcription of COL1A2, MMP2, and MMP9.	4-aminobenzhydrazide	107-111	collagen type I alpha 2 chain	Equus caballus	199-205
33467081-8	2021	The capacity of ABAH to inhibit MPO-induced COL1 was detected in follicular phase at 48 h (p < 0.05).	4-aminobenzhydrazide	16-20	myeloperoxidase	Equus caballus	32-35
33467081-9	2021	The gelatinolytic activity of activated MMP-2 augmented in mid-luteal phase at 24 h after MPO treatment, but it was reduced with MPO+ABAH treatment.	4-aminobenzhydrazide	133-137	matrix metallopeptidase 2	Equus caballus	40-45
32762560-3	2020	Since no scavenger for chlorinated lipids is available and based on the well-established role of the MPO/HOCl/chlorinated lipids axis in inflammatory responses, we hypothesized that treatment with MPO inhibitors (N-acetyl lysyltyrosylcysteine amide or 4-aminobenzoic acid hydrazide) would inhibit inflammation and proinflammatory mediator expression induced by cecal ligation and puncture (CLP).	4-aminobenzhydrazide	252-281	myeloperoxidase	Rattus norvegicus	197-200
33841526-3	2020	In this study, we designed, synthesized, and evaluated novel fatty acid amide hydrolase (FAAH) inhibitors based on 4-aminobenzohydrazide derivatives.	4-aminobenzhydrazide	115-136	fatty acid amide hydrolase	Homo sapiens	61-87
33841526-3	2020	In this study, we designed, synthesized, and evaluated novel fatty acid amide hydrolase (FAAH) inhibitors based on 4-aminobenzohydrazide derivatives.	4-aminobenzhydrazide	115-136	fatty acid amide hydrolase	Homo sapiens	89-93
32758448-8	2020	Finally, treatment of healthy neutrophils with an MPO inhibitor (4-Aminobenzoic acid hydrazide) increased cell viability and delayed apoptosis, highlighting a mechanism whereby MPO mutations affect granulocyte numbers.	4-aminobenzhydrazide	65-94	myeloperoxidase	Homo sapiens	50-53
32758448-8	2020	Finally, treatment of healthy neutrophils with an MPO inhibitor (4-Aminobenzoic acid hydrazide) increased cell viability and delayed apoptosis, highlighting a mechanism whereby MPO mutations affect granulocyte numbers.	4-aminobenzhydrazide	65-94	myeloperoxidase	Homo sapiens	177-180
29808380-4	2019	Mice induced with experimental autoimmune encephalomyelitis (EAE), a mouse model of neuroinflammation and multiple sclerosis, were treated with either the MPO-specific inhibitor 4-aminobenzoic acid hydrazide or saline as control.	4-aminobenzhydrazide	178-207	myeloperoxidase	Mus musculus	155-158
32035161-4	2020	METHODS: MPO-dependent ACS generation was determined by using hypochlorite-specific 3"-(p-aminophenyl) fluorescein (APF) and a highly potent MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH), and confirmed in PMN derived from MPO-/- mice.	4-aminobenzhydrazide	156-185	myeloperoxidase	Mus musculus	9-12
32035161-4	2020	METHODS: MPO-dependent ACS generation was determined by using hypochlorite-specific 3"-(p-aminophenyl) fluorescein (APF) and a highly potent MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH), and confirmed in PMN derived from MPO-/- mice.	4-aminobenzhydrazide	156-185	myeloperoxidase	Mus musculus	141-144
32035161-4	2020	METHODS: MPO-dependent ACS generation was determined by using hypochlorite-specific 3"-(p-aminophenyl) fluorescein (APF) and a highly potent MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH), and confirmed in PMN derived from MPO-/- mice.	4-aminobenzhydrazide	156-185	myeloperoxidase	Mus musculus	141-144
32035161-4	2020	METHODS: MPO-dependent ACS generation was determined by using hypochlorite-specific 3"-(p-aminophenyl) fluorescein (APF) and a highly potent MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH), and confirmed in PMN derived from MPO-/- mice.	4-aminobenzhydrazide	187-191	myeloperoxidase	Mus musculus	9-12
29673284-2	2019	We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO-/-), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke.	4-aminobenzhydrazide	75-104	myeloperoxidase	Mus musculus	18-21
29673284-2	2019	We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO-/-), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke.	4-aminobenzhydrazide	106-110	myeloperoxidase	Mus musculus	18-21
29673284-2	2019	We show that when MPO activity is either blocked by the specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) in wildtype (WT) mice or congenitally absent (MPO-/-), there was decreased cell loss, including degenerating neurons and oligodendrocytes, in the ischemic brains compared to vehicle-treated WT mice after stroke.	4-aminobenzhydrazide	106-110	myeloperoxidase	Mus musculus	158-161
29673284-8	2019	Therefore, MPO inhibition with ABAH or MPO deficiency creates a protective environment that decreased inflammatory cell recruitment and increased expression of survival factors to improve functional outcome.	4-aminobenzhydrazide	31-35	myeloperoxidase	Mus musculus	11-14
30789095-5	2020	DPI and 4-ABAH inhibited the carbamylation of albumin and NETosis.	4-aminobenzhydrazide	8-14	albumin	Homo sapiens	46-53
30218980-3	2018	Acute iron toxicity was also assessed in WT mice pretreated with an MPO inhibitor, 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	83-112	myeloperoxidase	Mus musculus	68-71
28796788-10	2017	Hamsters and mice were treated with an MPO inhibitor (4-aminobenzoic acid hydrazide).	4-aminobenzhydrazide	54-83	myeloperoxidase	Mus musculus	39-42
30206371-7	2018	Inhibition is also reversed in the presence of 4-aminobenzoic hydrazide, a myeloperoxidase inhibitor, suggesting epithelial cells have a peroxidase to convert Cl- to HOCl.	4-aminobenzhydrazide	47-71	myeloperoxidase	Homo sapiens	75-90
29626421-10	2018	4-Aminobenzoic acid hydrazide, a commonly used myeloperoxidase inhibitor, also inhibited peroxidasin, whereas acetaminophen and a 2-thioxanthine were much less effective.	4-aminobenzhydrazide	0-29	peroxidasin	Homo sapiens	89-100
29081812-5	2017	PIC1 reversibly and dose-dependently prevented TMB oxidation to tetramethylbenzidine diimine by RBC lysates, methemoglobin, and myoglobin, having comparable activity to the inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	183-212	small ubiquitin like modifier 1	Homo sapiens	0-4
28135312-6	2017	PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates.	4-aminobenzhydrazide	111-140	small ubiquitin like modifier 1	Homo sapiens	0-4
28135312-6	2017	PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates.	4-aminobenzhydrazide	111-140	myeloperoxidase	Homo sapiens	85-100
28135312-6	2017	PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates.	4-aminobenzhydrazide	142-146	small ubiquitin like modifier 1	Homo sapiens	0-4
28135312-6	2017	PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates.	4-aminobenzhydrazide	142-146	myeloperoxidase	Homo sapiens	15-30
28135312-6	2017	PIC1 inhibited myeloperoxidase activity similarly, on a molar basis, as the specific myeloperoxidase inhibitor 4-Aminobenzoic acid hydrazide (ABAH) for various oxidizing substrates.	4-aminobenzhydrazide	142-146	myeloperoxidase	Homo sapiens	85-100
27701922-8	2016	Pretreatment with the MPO inhibitor 4-aminobenzoic acid hydrazide dramatically enhanced both zymosan phagocytosis and the surface expression of CD11b in wild-type neutrophils, but not in MPO-/- neutrophils.	4-aminobenzhydrazide	36-65	myeloperoxidase	Mus musculus	22-25
27701922-8	2016	Pretreatment with the MPO inhibitor 4-aminobenzoic acid hydrazide dramatically enhanced both zymosan phagocytosis and the surface expression of CD11b in wild-type neutrophils, but not in MPO-/- neutrophils.	4-aminobenzhydrazide	36-65	integrin alpha M	Mus musculus	144-149
27550713-4	2016	In this study, we investigated whether the inhibition of MPO activity by a specific irreversible inhibitor, 4-aminobenzoic acid hydrazide (ABAH) (MPO-/- mice) can increase neurogenesis after transient middle cerebral artery occlusion in mice.	4-aminobenzhydrazide	108-137	myeloperoxidase	Mus musculus	57-60
27550713-4	2016	In this study, we investigated whether the inhibition of MPO activity by a specific irreversible inhibitor, 4-aminobenzoic acid hydrazide (ABAH) (MPO-/- mice) can increase neurogenesis after transient middle cerebral artery occlusion in mice.	4-aminobenzhydrazide	108-137	myeloperoxidase	Mus musculus	146-149
27550713-4	2016	In this study, we investigated whether the inhibition of MPO activity by a specific irreversible inhibitor, 4-aminobenzoic acid hydrazide (ABAH) (MPO-/- mice) can increase neurogenesis after transient middle cerebral artery occlusion in mice.	4-aminobenzhydrazide	139-143	myeloperoxidase	Mus musculus	57-60
27550713-4	2016	In this study, we investigated whether the inhibition of MPO activity by a specific irreversible inhibitor, 4-aminobenzoic acid hydrazide (ABAH) (MPO-/- mice) can increase neurogenesis after transient middle cerebral artery occlusion in mice.	4-aminobenzhydrazide	139-143	myeloperoxidase	Mus musculus	146-149
27550713-8	2016	MPO-deficient mice treated with vehicle or ABAH both showed similar effects on the number of BrdU+ cells in the ischemic hemisphere, demonstrating that ABAH is specific to MPO.	4-aminobenzhydrazide	43-47	myeloperoxidase	Mus musculus	0-3
27550713-8	2016	MPO-deficient mice treated with vehicle or ABAH both showed similar effects on the number of BrdU+ cells in the ischemic hemisphere, demonstrating that ABAH is specific to MPO.	4-aminobenzhydrazide	152-156	myeloperoxidase	Mus musculus	0-3
25760778-6	2015	MPO-evoked vasoconstrictions were prevented by the MPO inhibitor 4-aminobenzhydrazide (50 muM), by endothelium removal in the SMAs.	4-aminobenzhydrazide	65-85	myeloperoxidase	Rattus norvegicus	0-3
25759268-5	2015	This response was blocked by the irreversible myeloperoxidase inhibitor 4-amino-benzoic acid hydrazide, indicating peroxidase catalytic activity is essential for collagen biosynthesis.	4-aminobenzhydrazide	72-102	myeloperoxidase	Homo sapiens	46-61
27597056-3	2016	4-Aminobenzoic acid hydrazide, a potent inhibitor of peroxidase activity of myeloperoxidase, produced no effect on neutrophil degranulation.	4-aminobenzhydrazide	0-29	myeloperoxidase	Homo sapiens	76-91
25760778-6	2015	MPO-evoked vasoconstrictions were prevented by the MPO inhibitor 4-aminobenzhydrazide (50 muM), by endothelium removal in the SMAs.	4-aminobenzhydrazide	65-85	myeloperoxidase	Rattus norvegicus	51-54
26774631-3	2015	Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours.	4-aminobenzhydrazide	92-121	myeloperoxidase	Homo sapiens	78-81
25515211-4	2015	Mice were treated with 4-aminobenzoic acid hydrazide (ABAH), a specific irreversible MPO inhibitor.	4-aminobenzhydrazide	23-52	myeloperoxidase	Mus musculus	85-88
25515211-4	2015	Mice were treated with 4-aminobenzoic acid hydrazide (ABAH), a specific irreversible MPO inhibitor.	4-aminobenzhydrazide	54-58	myeloperoxidase	Mus musculus	85-88
26774631-3	2015	Studies were carried out on HL-60 cell line, which were preincubated with the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH), or antioxidant N-acetyl-L-cysteine (NAC), followed by incubation at different concentrations of etoposide (1-10 mM) for 4 hours.	4-aminobenzhydrazide	123-127	myeloperoxidase	Homo sapiens	78-81
24632143-4	2014	We determined that in the presence of hydrogen peroxide that 4-ABAH and its isomer 2-ABAH are both slow-tight binding inhibitors of MPO requiring at least two steps, whereas NaN3 and isoniazid-based inhibition has a single observable step.	4-aminobenzhydrazide	61-67	myeloperoxidase	Homo sapiens	132-135
25024373-5	2014	The MPO inhibitor 4-aminobenzoic acid hydrazide reduced peroxidase activity of neutrophils and prevented HFD-enhanced insulin resistance.	4-aminobenzhydrazide	18-47	myeloperoxidase	Mus musculus	4-7
16632121-13	2006	Inhibition of myeloperoxidase activity with 4-aminobenzoic acid hydrazide (4-ABAH) had minimal influence on the phototoxicity of VP in HL-60 cells in the absence of ascorbate.	4-aminobenzhydrazide	44-73	myeloperoxidase	Homo sapiens	14-29
23438680-9	2013	The zymosan-induced production of MIP-2 in the wild-type neutrophils was enhanced by pre-treatment of the MPO inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	120-149	chemokine (C-X-C motif) ligand 2	Mus musculus	34-39
23438680-9	2013	The zymosan-induced production of MIP-2 in the wild-type neutrophils was enhanced by pre-treatment of the MPO inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	120-149	myeloperoxidase	Mus musculus	106-109
22438365-2	2012	EAE was induced in SJL mice by using proteolipid protein (PLP), and mice were treated with either 4-aminobenzoic acid hydrazide (ABAH), 40 mg/kg injected intraperitoneally, an irreversible inhibitor of MPO, or saline as control, and followed up to day 40 after induction.	4-aminobenzhydrazide	98-127	myeloperoxidase	Mus musculus	202-205
22438365-8	2012	Inhibiting MPO activity with ABAH resulted in decrease in MPO-Gd-positive lesion volume (P = .012), number (P = .009), and enhancement intensity (P = .03) at MR imaging, reflecting lower local MPO activity (P = .03), compared with controls.	4-aminobenzhydrazide	29-33	myeloperoxidase	Mus musculus	11-14
22438365-8	2012	Inhibiting MPO activity with ABAH resulted in decrease in MPO-Gd-positive lesion volume (P = .012), number (P = .009), and enhancement intensity (P = .03) at MR imaging, reflecting lower local MPO activity (P = .03), compared with controls.	4-aminobenzhydrazide	29-33	myeloperoxidase	Mus musculus	58-61
22438365-8	2012	Inhibiting MPO activity with ABAH resulted in decrease in MPO-Gd-positive lesion volume (P = .012), number (P = .009), and enhancement intensity (P = .03) at MR imaging, reflecting lower local MPO activity (P = .03), compared with controls.	4-aminobenzhydrazide	29-33	myeloperoxidase	Mus musculus	58-61
19915640-3	2009	Specific MPO inhibitors, salicylhydroxamic acid or (4-aminobenzoyl)hydrazide, are added to measure the activity of other heme-containing peroxidases (mainly hemoglobin and its derivatives) and subtract their contribution from the total plasma peroxidase activity.	4-aminobenzhydrazide	51-76	myeloperoxidase	Homo sapiens	9-12
17875773-6	2007	Preincubation of myeloid leukemic cells with the MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, and the heme biosynthesis inhibitor, succinylacetone, resulted in inhibition of the intracellular MPO activity, ROS production, and induction of apoptosis following addition of EGCG.	4-aminobenzhydrazide	73-102	myeloperoxidase	Homo sapiens	49-52
17875773-6	2007	Preincubation of myeloid leukemic cells with the MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, and the heme biosynthesis inhibitor, succinylacetone, resulted in inhibition of the intracellular MPO activity, ROS production, and induction of apoptosis following addition of EGCG.	4-aminobenzhydrazide	73-102	myeloperoxidase	Homo sapiens	202-205
23691142-6	2013	Both, fMLP-activated leukocytes and the MPO-H2O2-Cl(-) system inflicted barrier dysfunction of primary brain microvascular endothelial cells (BMVEC) that was partially rescued with the MPO inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	199-228	myeloperoxidase	Mus musculus	40-43
23691142-6	2013	Both, fMLP-activated leukocytes and the MPO-H2O2-Cl(-) system inflicted barrier dysfunction of primary brain microvascular endothelial cells (BMVEC) that was partially rescued with the MPO inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	199-228	myeloperoxidase	Mus musculus	185-188
23455711-7	2013	In addition, co-administration of 4-aminobenzoic acid hydrazide (4-ABAH), an irreversible inhibitor of MPO, significantly attenuated luminescent emission from inflamed lungs.	4-aminobenzhydrazide	34-63	myeloperoxidase	Mus musculus	103-106
23455711-7	2013	In addition, co-administration of 4-aminobenzoic acid hydrazide (4-ABAH), an irreversible inhibitor of MPO, significantly attenuated luminescent emission from inflamed lungs.	4-aminobenzhydrazide	65-71	myeloperoxidase	Mus musculus	103-106
21840294-2	2011	We utilized 4-aminobenzoic acid hydrazide which was reported to be a potent irreversible inhibitor of myeloperoxidase to gain insight into the role of reactive metabolites in catalytic inhibition.	4-aminobenzhydrazide	12-41	myeloperoxidase	Homo sapiens	102-117
20699435-4	2010	Pretreatment of MPO-high leukemia cells with a MPO-specific inhibitor, 4-aminobenzoic acid hydrazide, or a MPO-specific small interfering RNA (siRNA) abrogated the PTL-induced ROS generation and apoptosis, indicating that MPO plays a crucial role in PTL-induced apoptosis in leukemia cells.	4-aminobenzhydrazide	71-100	myeloperoxidase	Homo sapiens	16-19
17675122-3	2008	MPO activity was measured using a specific modified o-dianisidine-assay containing 4-aminobenzoic acid hydrazide as a potent and specific inhibitor of the MPO.	4-aminobenzhydrazide	83-112	myeloperoxidase	Equus caballus	0-3
17675122-3	2008	MPO activity was measured using a specific modified o-dianisidine-assay containing 4-aminobenzoic acid hydrazide as a potent and specific inhibitor of the MPO.	4-aminobenzhydrazide	83-112	myeloperoxidase	Equus caballus	155-158
17440118-3	2007	Human alveolar epithelial cells (A549) were cocultured with activated neutrophils, and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	220-249	myeloperoxidase	Homo sapiens	188-203
17440118-3	2007	Human alveolar epithelial cells (A549) were cocultured with activated neutrophils, and we observed a significant reduction of NER in the A549 cells, which was abrogated by addition of the myeloperoxidase (MPO) inhibitor 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	220-249	myeloperoxidase	Homo sapiens	205-208
16632121-13	2006	Inhibition of myeloperoxidase activity with 4-aminobenzoic acid hydrazide (4-ABAH) had minimal influence on the phototoxicity of VP in HL-60 cells in the absence of ascorbate.	4-aminobenzhydrazide	75-81	myeloperoxidase	Homo sapiens	14-29
15893945-6	2005	In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells.	4-aminobenzhydrazide	41-62	myeloperoxidase	Homo sapiens	29-32
15893945-6	2005	In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells.	4-aminobenzhydrazide	41-62	nitric oxide synthase 2	Homo sapiens	73-77
15893945-6	2005	In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells.	4-aminobenzhydrazide	41-62	myeloperoxidase	Homo sapiens	91-94
15893945-6	2005	In addition, an inhibitor of MPO enzyme, 4-aminobenzohydrazide, enhanced iNOS induction in MPO-positive cells, but not in MPO-KO cells.	4-aminobenzhydrazide	41-62	myeloperoxidase	Homo sapiens	91-94
16024637-4	2005	Methimazole, 4-aminobenzoic acid hydrazide, or azide inhibits the reaction, suggesting that it is mediated by the cellular myeloperoxidase, an enzyme naturally present in large amounts in HL-60 cells.	4-aminobenzhydrazide	13-42	myeloperoxidase	Homo sapiens	123-138
10826917-7	2000	MPO inhibitors (4-aminobenzoic acid hydrazide, and isoniazid), GSH, L-cysteine, L-methionine and L-tryptophan prevented LADH inactivation by MPO/H2O2/NaNO2.	4-aminobenzhydrazide	16-45	myeloperoxidase	Sus scrofa	0-3
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	60-89	myeloperoxidase	Homo sapiens	37-40
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	60-89	myeloperoxidase	Homo sapiens	237-240
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	60-89	caspase 3	Homo sapiens	242-251
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	91-95	myeloperoxidase	Homo sapiens	37-40
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	91-95	myeloperoxidase	Homo sapiens	237-240
11981455-5	2002	Pre-incubation of the cells with the MPO-specific inhibitor 4-aminobenzoic acid hydrazide (ABAH) and the heme enzyme inhibitor 3-aminotriazole (100 microM each) resulted in complete and partial inhibition, respectively, of intracellular MPO, caspase-3 activity, and apoptosis following addition of 50 microM H(2)O(2).	4-aminobenzhydrazide	91-95	caspase 3	Homo sapiens	242-251
11738154-7	2001	Adding the MPO inhibitors 4-aminobenzoic acid hydrazide (ABAH) and indomethacin to the granulocytes, the generation of superoxide anion increased and the decreasing effect of the steroids on superoxide production was inhibited.	4-aminobenzhydrazide	26-55	myeloperoxidase	Homo sapiens	11-14
11738154-7	2001	Adding the MPO inhibitors 4-aminobenzoic acid hydrazide (ABAH) and indomethacin to the granulocytes, the generation of superoxide anion increased and the decreasing effect of the steroids on superoxide production was inhibited.	4-aminobenzhydrazide	57-61	myeloperoxidase	Homo sapiens	11-14
10801811-12	2000	When HL-60 cells were incubated with methimazole or 4-aminobenzoic acid hydrazide, which are inhibitors of myeloperoxidase, they no longer underwent H(2)O(2)-induced apoptosis.	4-aminobenzhydrazide	52-81	myeloperoxidase	Homo sapiens	107-122
10826917-7	2000	MPO inhibitors (4-aminobenzoic acid hydrazide, and isoniazid), GSH, L-cysteine, L-methionine and L-tryptophan prevented LADH inactivation by MPO/H2O2/NaNO2.	4-aminobenzhydrazide	16-45	myeloperoxidase	Sus scrofa	141-144
9020887-0	1997	Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide.	4-aminobenzhydrazide	48-77	myeloperoxidase	Homo sapiens	29-44
10994875-3	2000	Myeloperoxidase-mediated apoptosis induction is inhibited by SOD, catalase, 4-aminobenzoyl hydrazide, taurine and DMSO.	4-aminobenzhydrazide	76-100	myeloperoxidase	Homo sapiens	0-15
9020887-4	1997	In this investigation we show that, in the presence of hydrogen peroxide, ABAH irreversibly inactivates myeloperoxidase.	4-aminobenzhydrazide	74-78	myeloperoxidase	Homo sapiens	104-119
10092633-3	1999	4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation.	4-aminobenzhydrazide	0-29	myeloperoxidase	Homo sapiens	71-86
10092633-3	1999	4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation.	4-aminobenzhydrazide	31-35	myeloperoxidase	Homo sapiens	71-86
10092633-10	1999	ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation.	4-aminobenzhydrazide	0-4	myeloperoxidase	Homo sapiens	21-36
7635354-9	1995	the rate constant reaction of 1-hydroxyethyl free radicals with Cu,Zn-SOD was measured separately by competition kinetics with the spin trapping agent alpha-(4-pyridyl 1-oxide) N-terbutylnitrone (4-POBN), after having measured the rate constant of scavenging of 1-hydroxyethyl free radicals by 4-POBN in the absence of SOD.	4-aminobenzhydrazide	196-202	superoxide dismutase 1	Homo sapiens	70-73
9020887-5	1997	ABAH was oxidized by myeloperoxidase, and kinetic analysis of the inactivation conformed to that for a mechanism-based inhibitor.	4-aminobenzhydrazide	0-4	myeloperoxidase	Homo sapiens	21-36
9020887-9	1997	In the presence of oxygen, ABAH and hydrogen peroxide initially converted myeloperoxidase into compound III, which subsequently lost haem absorbance.	4-aminobenzhydrazide	27-31	myeloperoxidase	Homo sapiens	74-89
9020887-11	1997	We propose that myeloperoxidase oxidizes ABAH to a radical that reduces the enzyme to its ferrous intermediate.	4-aminobenzhydrazide	41-45	myeloperoxidase	Homo sapiens	16-31
7635354-13	1995	Free radicals derived from ethanol metabolism can thus react SOD leading to enzyme inactivation, besides the fact that the reactivities of 1-hydroxyethyl radicals with 4-POBN and with proteins such as Cu,Zn SOD are of the same order of magnitude could explain the difficulties to trap in vivo these radicals.	4-aminobenzhydrazide	168-174	superoxide dismutase 1	Homo sapiens	61-64
7635354-9	1995	the rate constant reaction of 1-hydroxyethyl free radicals with Cu,Zn-SOD was measured separately by competition kinetics with the spin trapping agent alpha-(4-pyridyl 1-oxide) N-terbutylnitrone (4-POBN), after having measured the rate constant of scavenging of 1-hydroxyethyl free radicals by 4-POBN in the absence of SOD.	4-aminobenzhydrazide	294-300	superoxide dismutase 1	Homo sapiens	70-73
35301114-3	2022	To study temperature-dependent innate immune activity, 4-aminobenzoic hydrazide (4-AH), a myeloperoxidase (MPO) inhibitor, was used to treat VHSV-infected olive flounders reared at a high temperature of 20  C (20VI).	4-aminobenzhydrazide	55-79	myeloperoxidase	Homo sapiens	90-105
7772042-14	1995	Thus ABAH is an effective and selective inhibitor that should be useful for determining the contribution of myeloperoxidase to oxidant-mediated reactions of neutrophils.	4-aminobenzhydrazide	5-9	myeloperoxidase	Homo sapiens	108-123
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	95-101	spindlin 1	Homo sapiens	19-23
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	95-101	spindlin 1	Homo sapiens	34-38
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	95-101	spindlin 1	Homo sapiens	34-38
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	191-197	spindlin 1	Homo sapiens	19-23
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	191-197	spindlin 1	Homo sapiens	34-38
1314821-1	1992	Using the electron spin resonance/spin trapping system, 4-pyridyl 1-oxide N-tert-butylnitrone (4-POBN)/ethanol, hydroxyl radical was detected as the alpha-hydroxyethyl spin trapped adduct of 4-POBN, 4-POBN-CH(CH3)OH, from phorbol 12-myristate 13-acetate-stimulated human neutrophils and monocytes without the addition of supplemental iron.	4-aminobenzhydrazide	191-197	spindlin 1	Homo sapiens	34-38
35301114-3	2022	To study temperature-dependent innate immune activity, 4-aminobenzoic hydrazide (4-AH), a myeloperoxidase (MPO) inhibitor, was used to treat VHSV-infected olive flounders reared at a high temperature of 20  C (20VI).	4-aminobenzhydrazide	55-79	myeloperoxidase	Homo sapiens	107-110
35247801-6	2022	To observe MPO"s effects on post-radiation tumor progression, we then irradiated the head with 10 Gy unfractionated and treated the mice with a specific MPO inhibitor, 4-aminobenzoic acid hydrazide (ABAH), or vehicle as control.	4-aminobenzhydrazide	199-203	myeloperoxidase	Mus musculus	153-156
3026385-2	1986	The spin trap, alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN) was included in the lipoxygenase system to capture short-lived free radicals.	4-aminobenzhydrazide	59-65	linoleate 9S-lipoxygenase-4	Glycine max	87-99
35269694-4	2022	To translate our findings in an in vivo model, we tested the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH) in C3HeB/FeJ mice, which are highly susceptible to M. tuberculosis infection manifesting in neutrophil-associated necrotic granulomas.	4-aminobenzhydrazide	75-104	myeloperoxidase	Mus musculus	61-64
35269694-4	2022	To translate our findings in an in vivo model, we tested the MPO inhibitor 4-aminobenzoic acid hydrazide (ABAH) in C3HeB/FeJ mice, which are highly susceptible to M. tuberculosis infection manifesting in neutrophil-associated necrotic granulomas.	4-aminobenzhydrazide	106-110	myeloperoxidase	Mus musculus	61-64
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	4-aminobenzhydrazide	151-157	linoleate 9S-lipoxygenase-4	Glycine max	92-104