PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25856560-7	2015	Microemulsions stabilized by the mixture of Polisorbat 80 and 1-butanol were characterized by the largest degree of dispersion (137 nm) and the lowest PDI value (0.094), at surfactant/co-surfactant: oil weight ratio 90:10.	1-Butanol	62-71	peptidyl arginine deiminase 1	Homo sapiens	151-154
25741350-3	2015	In our previous research, we showed in Arabidopsis suspension cells that n-butanol, which specifically modulates phospholipase D activity, significantly suppresses the transcription of the pathogenesis related (PR-1) gene, which is generally accepted as the SA pathway marker.	1-Butanol	73-82	phospholipase D delta	Arabidopsis thaliana	113-128
25741350-3	2015	In our previous research, we showed in Arabidopsis suspension cells that n-butanol, which specifically modulates phospholipase D activity, significantly suppresses the transcription of the pathogenesis related (PR-1) gene, which is generally accepted as the SA pathway marker.	1-Butanol	73-82	pathogenesis-related protein 1	Arabidopsis thaliana	211-215
25741350-5	2015	We were able to show in Arabidopsis plants treated with SA that n-butanol inhibits the transcription of defense genes (PR-1, WRKY38).	1-Butanol	64-73	pathogenesis-related protein 1	Arabidopsis thaliana	119-123
25741350-5	2015	We were able to show in Arabidopsis plants treated with SA that n-butanol inhibits the transcription of defense genes (PR-1, WRKY38).	1-Butanol	64-73	WRKY DNA-binding protein 38	Arabidopsis thaliana	125-131
25741350-6	2015	Fluorescence microscopy of Arabidopsis thaliana mutants expressing 35S::NPR1-GFP (nonexpressor pathogenesis related 1) revealed significantly decreased nuclear localization of NPR1 in the presence of n-butanol.	1-Butanol	200-209	regulatory protein (NPR1)	Arabidopsis thaliana	72-76
25741350-6	2015	Fluorescence microscopy of Arabidopsis thaliana mutants expressing 35S::NPR1-GFP (nonexpressor pathogenesis related 1) revealed significantly decreased nuclear localization of NPR1 in the presence of n-butanol.	1-Butanol	200-209	regulatory protein (NPR1)	Arabidopsis thaliana	176-180
25560388-10	2015	Since then, significant theoretical and experimental efforts have focused on determining the rate coefficients of primary n-butanol consumption pathways in combustion environments, including H atom abstraction reactions from n-butanol by key radicals such as HO2 and OH, as well as the decomposition of the radicals formed by these H atom abstractions.	1-Butanol	122-131	heme oxygenase 2	Homo sapiens	259-269
25557029-8	2015	RESULTS: The results demonstrated that n-hexane, ethyl acetate and n-butanol extracts from the flower of E.gardneri were able to significantly activate PPARgamma and PPARbeta respectively, and the activity of ethyl acetate extract was much better.	1-Butanol	67-76	peroxisome proliferator activated receptor delta	Homo sapiens	166-174
25112316-1	2014	3-Hydroxybutyryl-CoA dehydrogenase is an enzyme that catalyzes the second step in the biosynthesis of n-butanol from acetyl-CoA, in which acetoacetyl-CoA is reduced to 3-hydroxybutyryl-CoA.	1-Butanol	102-111	ATN24_RS03170	Clostridium butyricum	0-34
26089893-8	2015	Inhibition of PLD by a general antagonist (1-butanol) or specific inhibitor, halopemide, or N-hexanoylsphingosine, or by cellular ceramides accumulated in doxorubicin-treated hepatocytes decreased insulin-stimulated glucose metabolism.	1-Butanol	43-52	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17
25112316-2	2014	To understand the molecular mechanisms of n-butanol biosynthesis, we determined the crystal structure of 3-hydroxybutyryl-CoA dehydrogenase from Clostridium butyricum (CbHBD).	1-Butanol	42-51	ATN24_RS03170	Clostridium butyricum	105-139
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	myeloperoxidase	Mus musculus	82-85
25523098-6	2014	PLD induction of HIF-1alpha was significantly attenuated by 1-butanol which blocks PA production by PLD, and PA per se was able to elevate HIF-1alpha protein level.	1-Butanol	60-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
25523098-6	2014	PLD induction of HIF-1alpha was significantly attenuated by 1-butanol which blocks PA production by PLD, and PA per se was able to elevate HIF-1alpha protein level.	1-Butanol	60-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
25523098-6	2014	PLD induction of HIF-1alpha was significantly attenuated by 1-butanol which blocks PA production by PLD, and PA per se was able to elevate HIF-1alpha protein level.	1-Butanol	60-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	100-103
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	adenosine deaminase	Mus musculus	90-93
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	interleukin 1 beta	Mus musculus	113-121
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	tumor necrosis factor	Mus musculus	123-132
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	interleukin 17A	Mus musculus	138-144
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	interleukin 1 beta	Mus musculus	181-189
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	tumor necrosis factor	Mus musculus	191-200
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	interleukin 17A	Mus musculus	202-208
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	nitric oxide synthase 2, inducible	Mus musculus	210-214
25168307-8	2014	Animals pre-treated with CE, BuOH, Aq, SA, or LA inhibited leukocytes, exudation, MPO and ADA activities, NO x , IL-1beta, TNF-alpha, and IL-17A levels, and the mRNA expression for IL-1beta, TNF-alpha, IL-17A, iNOS, and p65 protein phosphorylation (NF-kappaB) (p < 0.05).	1-Butanol	29-33	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	220-223
25242291-8	2014	Assessing for genetic rationale for tolerance, it was observed that 1-butanol-tolerant strains, when compared with 1-butanol-sensitive strains, had an up-regulation of RPN4, a transcription factor which regulates proteasome genes.	1-Butanol	68-77	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	168-172
25242291-8	2014	Assessing for genetic rationale for tolerance, it was observed that 1-butanol-tolerant strains, when compared with 1-butanol-sensitive strains, had an up-regulation of RPN4, a transcription factor which regulates proteasome genes.	1-Butanol	115-124	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	168-172
25242291-9	2014	Analysing for the importance of RPN4, we observed that a Deltarpn4 strain displayed a reduced rate of fermentation in the presence of 1-butanol when compared with the BY4741 background strain.	1-Butanol	134-143	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	32-36
25275439-2	2014	Like other primary alcohols, 1-butanol is a substrate for PLD and thereby disrupts formation of the intracellular signaling lipid phosphatidic acid.	1-Butanol	29-38	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	58-61
25070190-9	2014	RESULTS: It was found that TNF-alpha could be significantly suppressed by ACE extracts, whereas IL-1 was dramatically inhibited by BU extracts, which was further confirmed by dose-dependent experiments.	1-Butanol	131-133	interleukin 1 alpha	Homo sapiens	96-100
25470972-4	2014	RESULTS: The serum containing n-butanol fractions from Gynostemma pentaphyllum significantly inhibited the NG108-15 cells apoptosis induced by Abeta25-35 protein in vitro,and decreased the cellular Caspase-3 level.	1-Butanol	30-39	caspase 3	Mus musculus	198-207
24853351-5	2014	By inactivating ADH1 and ADH4 for ethanol formation and GPD1 and GPD2 for glycerol production, the glycolytic flux was redirected towards acetyl-CoA, resulting in 4-fold improvement in n-butanol production.	1-Butanol	185-194	alcohol dehydrogenase ADH1	Saccharomyces cerevisiae S288C	16-20
24853351-5	2014	By inactivating ADH1 and ADH4 for ethanol formation and GPD1 and GPD2 for glycerol production, the glycolytic flux was redirected towards acetyl-CoA, resulting in 4-fold improvement in n-butanol production.	1-Butanol	185-194	alcohol dehydrogenase ADH4	Saccharomyces cerevisiae S288C	25-29
24853351-5	2014	By inactivating ADH1 and ADH4 for ethanol formation and GPD1 and GPD2 for glycerol production, the glycolytic flux was redirected towards acetyl-CoA, resulting in 4-fold improvement in n-butanol production.	1-Butanol	185-194	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1	Saccharomyces cerevisiae S288C	56-60
24853351-5	2014	By inactivating ADH1 and ADH4 for ethanol formation and GPD1 and GPD2 for glycerol production, the glycolytic flux was redirected towards acetyl-CoA, resulting in 4-fold improvement in n-butanol production.	1-Butanol	185-194	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	65-69
24651643-8	2014	The determination of the Km values towards L-threonine (Km = 11.29 micrometer), ethanol (222.5 micrometer), and n-butanol (8.02 micrometer) also confirmed the enzyme as an LTDH.	1-Butanol	112-121	L-threonine dehydrogenase	Escherichia coli str. K-12 substr. MG1655	172-176
25470972-5	2014	CONCLUSION: The inhibition effect of n-butanol fractions from Gynostemma pentaphyllum on NG108-15 cell apoptosis induced by Abeta25.35 protein is likely related to its potency on reducing of cellular Caspase-3 level.	1-Butanol	37-46	caspase 3	Mus musculus	200-209
24262632-3	2014	We here report that insulin-like growth factor 1 (IGF-1) is a strong mitogen for rat astrocytes (EC50 0.2 mug/ml) and a strong stimulator of astroglial PLD activity; both effects are inhibited by ethanol and 1-butanol, but not t-butanol, suggesting participation of PLD.	1-Butanol	208-217	insulin-like growth factor 1	Rattus norvegicus	20-48
24262632-3	2014	We here report that insulin-like growth factor 1 (IGF-1) is a strong mitogen for rat astrocytes (EC50 0.2 mug/ml) and a strong stimulator of astroglial PLD activity; both effects are inhibited by ethanol and 1-butanol, but not t-butanol, suggesting participation of PLD.	1-Butanol	208-217	insulin-like growth factor 1	Rattus norvegicus	50-55
24253251-8	2014	The effects of 1-butanol were absent in mice that lack PLD1 (Pld1(-/-) mice) or that selectively lack the CaV1.2 channel in smooth muscle (sm-CaV1.2(-/-) mice) but still present in the heterozygous control mice.	1-Butanol	15-24	phospholipase D1	Mus musculus	61-76
24597831-10	2014	However, in case of in vivo assay, an increase of SOD and T-AOC and decrease of MDA and LDH levels were only observed in n-butanol (2 mg/kg/d of crude drug) extracts pretreatment group.	1-Butanol	121-130	superoxide dismutase 1	Homo sapiens	50-53
24597831-11	2014	CONCLUSIONS: RT saponins in n-butanol fraction might be a potential antioxidant candidate, as CCl4-induced oxidative stress has been found to be alleviated, which may be associated with the time dependent manner of n-butanol saponins in a low dose.	1-Butanol	28-37	C-C motif chemokine ligand 4	Homo sapiens	94-98
24618697-6	2014	Treatment of cells with the primary alcohol 1-butanol inhibits the hydrolysis of phosphatidylcoline by PLD thereby suppressing phosphatidic acid (PA) production.	1-Butanol	44-53	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	103-106
24618697-8	2014	When HSY cells were incubated with 1-butanol the total number of clathrin coated vesicles increased, especially in the juxtanuclear region and the co-localization of PLD with the clathrin coated vesicles was augmented.	1-Butanol	35-44	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	166-169
24252230-4	2014	In this manuscript we report SANS, fluorescence and rheological studies on the effect of n-butanol on gelation characteristics of aqueous F127 solutions.	1-Butanol	89-98	USH1 protein network component sans	Homo sapiens	29-33
24491552-8	2014	Furthermore, 1-butanol greatly induced filamentous growth when RCK1 was over-expressed.	1-Butanol	13-22	putative serine/threonine protein kinase RCK1	Saccharomyces cerevisiae S288C	63-67
24491552-10	2014	The growth defect of cells observed on 1-butanol medium was recovered when RCK1 was over-expressed.	1-Butanol	39-48	putative serine/threonine protein kinase RCK1	Saccharomyces cerevisiae S288C	75-79
24444890-4	2014	We found that dichloromethane and n-butanol sub-fractions of COCH-Et promoted glucose uptake in differentiated C2C12 cells at 50 mug/mL.	1-Butanol	34-43	cochlin	Mus musculus	61-65
24252230-6	2014	SANS and fluorescence studies attribute this to enhancement in micellar solvation due to solubilization of n-butanol.	1-Butanol	107-116	USH1 protein network component sans	Homo sapiens	0-4
24252230-7	2014	Quite interestingly, SANS studies show that n-butanol induced F127 gels form at significantly lower micellar volume fraction than the pure F127 gels.	1-Butanol	44-53	USH1 protein network component sans	Homo sapiens	21-25
25422194-0	2014	N-butanol extract of Capparis spinosa L. induces apoptosis primarily through a mitochondrial pathway involving mPTP open, cytochrome C release and caspase activation.	1-Butanol	0-9	cytochrome c, somatic	Homo sapiens	122-134
24316011-10	2014	While BA induced a larger PEPC activity in PC, and higher catalase activity as well.	1-Butanol	6-8	phosphoenolpyruvate carboxylase 1	Zea mays	26-30
24883171-4	2014	The gas-phase concentration of n-butanol at the tip of each pen was measured directly in a new set of pens via proton-transfer-reaction mass spectrometry (PTR-MS).	1-Butanol	31-40	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	60-63
24269248-7	2014	n-Butanol soluble fraction of the water extract of Chinese toon fruit reduced the levels of nitrate, nitrite, lipid peroxidation, cyclooxygenase-1, thromboxane in post-ischemic brain.	1-Butanol	0-9	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	130-146
25228267-5	2013	The active n-butanol fraction was evaluated for its inhibition against HIV-1 reverse transcriptase, integrase, protease, pro-viral genome integration and viral Tat protein mediated transactivation.	1-Butanol	11-20	Tat	Human immunodeficiency virus 1	160-163
25228267-12	2013	The n-butanol fraction interfered with the Tat-mediated Long Terminal Repeat transactivation in TZM-bl cells, mRNA quantitation (qRT-PCR) and electrophoretic mobility shift assay (EMSA).	1-Butanol	4-13	tyrosine aminotransferase	Homo sapiens	43-46
25434188-1	2013	There was studied action of aliphatic alcohols (ethanol, propanol, isopropanol, n-butanol, isobutanol, secbutanol, tretbetanol) and pH on various kinds of reactional capability the serum cholinesterase.	1-Butanol	80-89	butyrylcholinesterase	Homo sapiens	187-201
23928664-9	2013	RESULTS: After intranasal insulin administration, subjects" sensitivity for the odorant n-butanol was significantly decreased compared with that for the placebo condition (-13%; P = .025), whereas olfactory discrimination ability was not (P = .841).	1-Butanol	88-97	insulin	Homo sapiens	26-33
23762411-6	2013	Here, we show that application of n-butanol, an inhibitor of PLD, and N-Acylethanolamine (NAE) 12:0, a specific inhibitor of PLDalpha1, retarded ABA-promoted senescence to different extents.	1-Butanol	34-43	phospholipase D delta	Arabidopsis thaliana	61-64
24014914-7	2013	The test samples, except n-butanol fraction, exhibited inhibitory effect for both COX-1 and COX-2, in in-vitro assay but their percentage of inhibition values differs from each other.	1-Butanol	25-34	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	82-87
24014914-7	2013	The test samples, except n-butanol fraction, exhibited inhibitory effect for both COX-1 and COX-2, in in-vitro assay but their percentage of inhibition values differs from each other.	1-Butanol	25-34	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	92-97
23647018-2	2013	The enriched bamboo shoot angiotensin converting enzyme (ACE) inhibitory peptide preparation fraction (called BSP for short) was extracted with ethyl acetate and n-butanol.	1-Butanol	162-171	angiotensin I converting enzyme	Rattus norvegicus	57-60
23647018-3	2013	The ethyl acetate fraction and n-butanol fraction exhibited higher antioxidant capacities than the leaving water fraction (BSML), which was attributed to the higher phenolic acid and flavonoid content of both fractions, while BSML exhibited the strongest ACE inhibitory activity.	1-Butanol	31-40	angiotensin I converting enzyme	Rattus norvegicus	255-258
23471562-4	2013	Moreover, the n-butanol fraction significantly (p < 0.05) decreased PGE2 and TNF-alpha in the exudates of rat paw edema.	1-Butanol	14-23	tumor necrosis factor	Rattus norvegicus	80-89
23789221-5	2013	Among the fractions tested, n-butanol fraction showed the strongest AChE inhibition (43.4% at a final dose of 0.03 mg/mL) and also exhibited outstanding efficacy (65.9% at a dose of 250 mg/kg) in an experimental model of amnesia.	1-Butanol	28-37	acetylcholinesterase	Mus musculus	68-72
23500715-5	2013	Adding of primary alcohol (1-butanol) to the incubation medium led to phosphatidylbutanol accumulation as a result of phospholipase D (PLD) action in wild-type and NADPH-oxidase RbohD deficient plants.	1-Butanol	27-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	118-133
23500715-5	2013	Adding of primary alcohol (1-butanol) to the incubation medium led to phosphatidylbutanol accumulation as a result of phospholipase D (PLD) action in wild-type and NADPH-oxidase RbohD deficient plants.	1-Butanol	27-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	135-138
23552365-7	2013	Two independently evolved n-butanol-tolerant strains carried different mutations in both RPN4 and RTG1, which encode transcription factors involved in the expression of proteasome and peroxisomal genes, respectively.	1-Butanol	26-35	stress-regulated transcription factor RPN4	Saccharomyces cerevisiae S288C	89-93
23552365-7	2013	Two independently evolved n-butanol-tolerant strains carried different mutations in both RPN4 and RTG1, which encode transcription factors involved in the expression of proteasome and peroxisomal genes, respectively.	1-Butanol	26-35	Rtg1p	Saccharomyces cerevisiae S288C	98-102
23178798-3	2013	Therefore, the relationship between AngII-activated PLD and PKD was determined in two glomerulosa cell models, primary bovine zona glomerulosa (ZG) and HAC15 human adrenocortical carcinoma cells, using two inhibitors, 1-butanol and the reported PLD inhibitor, fluoro-2-indolyl des-chlorohalopemide (FIPI).	1-Butanol	218-227	angiotensinogen	Homo sapiens	36-41
23332938-5	2013	More specifically, Na(4)BP-10 forms nanometer-sized micelles with an aggregation number close to 5 (at concentrations above the critical micellar concentration) in both 20 mM NaCl and 0.9 wt.% 1-butanol media.	1-Butanol	193-202	BP10	Homo sapiens	24-29
23178798-5	2013	Subsequently, it was shown that both 1-butanol and FIPI inhibited AngII-elicited PKD activation and aldosterone production.	1-Butanol	37-46	angiotensinogen	Homo sapiens	66-71
22833369-1	2013	The recovery of 1-butanol from fermentation broth is energy-intensive since typical concentrations in fermentation broth are below 20 g L(-1).	1-Butanol	16-25	immunoglobulin kappa variable 1-16	Homo sapiens	136-141
23178798-5	2013	Subsequently, it was shown that both 1-butanol and FIPI inhibited AngII-elicited PKD activation and aldosterone production.	1-Butanol	37-46	protein kinase D1	Homo sapiens	81-84
23031574-4	2013	Chemical shift perturbation introduced by 1-butanol on residues Gln320, Thr321, Phe322 and Arg323 of L45, as well as Thr423 and Gln424 of S6c indicates possible anesthetic binding sites on these two important components in the channel activation apparatus.	1-Butanol	42-51	l(4)102CDd	Drosophila melanogaster	101-104
23031574-5	2013	Diffusion measurements confirmed the association of L45, S6c and 1-butanol with micelles which suggests the capability of 1-butanol to influence a possible interaction of L45 and S6c in the micelle environment.	1-Butanol	65-74	l(4)102CDd	Drosophila melanogaster	171-174
23031574-5	2013	Diffusion measurements confirmed the association of L45, S6c and 1-butanol with micelles which suggests the capability of 1-butanol to influence a possible interaction of L45 and S6c in the micelle environment.	1-Butanol	122-131	l(4)102CDd	Drosophila melanogaster	52-55
23031574-5	2013	Diffusion measurements confirmed the association of L45, S6c and 1-butanol with micelles which suggests the capability of 1-butanol to influence a possible interaction of L45 and S6c in the micelle environment.	1-Butanol	122-131	l(4)102CDd	Drosophila melanogaster	171-174
23032700-5	2013	Cobalamin-induced down-regulation of Multidrug Resistance-1 gene expression was similar to that induced by the phospholipase D activator oleic acid and was negatively modulated by the phospholipase D inhibitor n-butanol.	1-Butanol	210-219	ATP binding cassette subfamily B member 1	Homo sapiens	37-59
23681537-4	2013	The protocol takes advantage of a unique property of PLD, i.e., its ability to substitute a primary alcohol, such as 1-butanol, for water in the hydrolytic reaction.	1-Butanol	117-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
23662182-5	2013	1-Butanol, the quencher of PLD, generated PA leading to the formation of physiologically inactive phosphatidyl butanol but not its biologically inactive analog, 2-butanol, blocked the H2O2-mediated barrier dysfunction.	1-Butanol	0-9	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
22923966-0	2012	Hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl(4) -induced liver damage in rats.	1-Butanol	69-78	C-C motif chemokine ligand 4	Rattus norvegicus	117-123
22564901-5	2012	Moreover, a decrease in the mitochondrial membrane potential, the cytosolic release of cytochrome c, and the activation of caspase 9 and 3 was observed, thus revealing the activation of the mitochondrial apoptotic pathway by 1-butanol.	1-Butanol	225-234	cytochrome c, somatic	Homo sapiens	87-99
22564901-5	2012	Moreover, a decrease in the mitochondrial membrane potential, the cytosolic release of cytochrome c, and the activation of caspase 9 and 3 was observed, thus revealing the activation of the mitochondrial apoptotic pathway by 1-butanol.	1-Butanol	225-234	caspase 9	Homo sapiens	123-138
22923966-1	2012	OBJECTIVE: to investigate the hepatoprotective potential of ether insoluble phenolic components of n-butanol fraction (EPC-BF) of flaxseed against CCl(4) -induced liver damage in rats.	1-Butanol	99-108	C-C motif chemokine ligand 4	Rattus norvegicus	147-153
22571264-6	2012	Pretreatment of platelets with 1-butanol significantly attenuated thrombin-induced increase in [Ca2+](i) , while thrombin-induced increase in [Ca2+](i) was augmented in the presence of propranolol.	1-Butanol	31-40	coagulation factor II, thrombin	Homo sapiens	66-74
22392280-6	2012	ABA-induced stomatal closure in both pldalpha1 and plddelta single mutants was inhibited by a PLD inhibitor (1-butanol ), suggesting that both PLDalpha1 and PLDdelta function in ABA-induced stomatal closure.	1-Butanol	109-118	phospholipase D alpha 1	Arabidopsis thaliana	37-46
22466954-5	2012	In the presence of 0.8 % (v/v, 6.5 g/l) 1-butanol, the growth rate of MT5 was found to be 0.28 h(-1) while that of wild type was 0.20 h(-1).	1-Butanol	40-49	protease, serine 32	Mus musculus	70-73
22466954-6	2012	When 1-butanol concentration increased to 1.2 % (9.7 g/l), the growth rate of MT5 (0.18 h(-1)) became twice that of the wild type (0.09 h(-1)).	1-Butanol	5-14	protease, serine 32	Mus musculus	78-81
22466954-7	2012	Microbial adhesion to hydrocarbon test showed that cell surface of MT5 was less hydrophobic and its cell length became significantly longer in the presence of 1-butanol, as observed by scanning electron microscopy.	1-Butanol	159-168	protease, serine 32	Mus musculus	67-70
22466954-8	2012	Quantitative real-time reverse transcription PCR analysis revealed that several CRP regulated, 1-butanol stress response related genes (rpoH, ompF, sodA, manX, male, and marA) demonstrated differential expression in MT5 in the presence or absence of 1-butanol.	1-Butanol	95-104	protease, serine 32	Mus musculus	216-219
22466954-8	2012	Quantitative real-time reverse transcription PCR analysis revealed that several CRP regulated, 1-butanol stress response related genes (rpoH, ompF, sodA, manX, male, and marA) demonstrated differential expression in MT5 in the presence or absence of 1-butanol.	1-Butanol	250-259	protease, serine 32	Mus musculus	216-219
22392280-6	2012	ABA-induced stomatal closure in both pldalpha1 and plddelta single mutants was inhibited by a PLD inhibitor (1-butanol ), suggesting that both PLDalpha1 and PLDdelta function in ABA-induced stomatal closure.	1-Butanol	109-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	94-97
22392280-6	2012	ABA-induced stomatal closure in both pldalpha1 and plddelta single mutants was inhibited by a PLD inhibitor (1-butanol ), suggesting that both PLDalpha1 and PLDdelta function in ABA-induced stomatal closure.	1-Butanol	109-118	phospholipase D alpha 1	Arabidopsis thaliana	143-152
22246733-6	2012	The effects of various reaction parameters on activity and stability of Candida antarctica lipase B and lipase from Pseudomonas cepacia were investigated using the transesterification of ethyl butyrate with n-butanol as a model reaction.	1-Butanol	207-216	PAN0_003d1715	Moesziomyces antarcticus	72-110
22078843-0	2012	Characterization of compounds and potential neuraminidase inhibitors from the n-butanol extract of Compound Indigowoad Root Granule using ultrafiltration and liquid chromatography-tandem mass spectrometry.	1-Butanol	78-87	neuraminidase 1	Homo sapiens	44-57
22004473-3	2012	All the concentrations (3.125-200 mg mL-1) of chloroform, ethyl acetate and n-butanol fractions of leaf extract, and n-hexane fraction of fruit extract completely inhibited the target fungal growth.	1-Butanol	76-85	L1 cell adhesion molecule	Mus musculus	37-41
23082080-2	2012	We investigated the inhibitory effect of the n-butanol fraction of HRT (HRT-BU) and fHRT (fHRT-BU) on the RANKL-induced osteoclastogenesis in bone-marrow-derived macrophages.	1-Butanol	45-54	TNF superfamily member 11	Rattus norvegicus	106-111
21892616-4	2011	Among fractions, ethyl acetate fraction (EF) and n-butanol extract (BF) exhibited potent hepatoprotective activities (62.60% for EF and 64.86% for BF) in t-BHP-injured HepG2 cells at a concentration of 10 mug/mL-1.	1-Butanol	49-58	L1 cell adhesion molecule	Mus musculus	209-213
21398484-4	2011	In this work, we constructed a modified clostridial 1-butanol pathway in Escherichia coli to provide an irreversible reaction catalyzed by trans-enoyl-coenzyme A (CoA) reductase (Ter) and created NADH and acetyl-CoA driving forces to direct the flux.	1-Butanol	52-61	Ter DNA replication terminus site binding protein	Escherichia coli	179-182
21791551-10	2011	Furthermore, n-butanol extract from kakrol caused a significant concentration-dependent decrease in the pancreatic lipase activity in vitro.	1-Butanol	13-22	pancreatic lipase	Rattus norvegicus	104-121
21815623-0	2011	Generation of counter ion radical (Br2( -)) and its reactions in water-in-oil (CTAB or CPB)/n-butanol/cyclohexane/water) microemulsion.	1-Butanol	92-101	carboxypeptidase B1	Homo sapiens	87-90
21925888-6	2011	The n-BuOH-soluble fraction and chakasaponin II suppressed mRNA levels of neuropeptide Y (NPY), an important regulator of body weight through its effects on food intake and energy expenditure, in the hypothalamus.	1-Butanol	6-10	neuropeptide Y	Mus musculus	74-88
21925888-6	2011	The n-BuOH-soluble fraction and chakasaponin II suppressed mRNA levels of neuropeptide Y (NPY), an important regulator of body weight through its effects on food intake and energy expenditure, in the hypothalamus.	1-Butanol	6-10	neuropeptide Y	Mus musculus	90-93
21620893-8	2011	Blocking PA production with 1-butanol and siRNA against PLD1 significantly inhibited the IL-15-stimulated expression of RANKL and PLD1.	1-Butanol	28-37	interleukin 15	Homo sapiens	89-94
21620893-8	2011	Blocking PA production with 1-butanol and siRNA against PLD1 significantly inhibited the IL-15-stimulated expression of RANKL and PLD1.	1-Butanol	28-37	TNF superfamily member 11	Homo sapiens	120-125
21687964-6	2011	Furthermore, the transformant of rELO2 also conferred tolerance to n-butanol, n-propanol, and 2-propanol.	1-Butanol	67-76	ELOVL fatty acid elongase 6	Rattus norvegicus	33-38
21718292-3	2011	KEY FINDINGS: We report for the first time the anti-cancer potential of C. spinarum stem aqueous extract (CSE) and its n-butanol fraction (CSF).	1-Butanol	119-128	colony stimulating factor 2	Homo sapiens	139-142
21384098-4	2011	Increased cytokine secretion and cPLA(2) and Cox-2 levels in Snca-/- microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment.	1-Butanol	148-157	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	33-40
21384098-4	2011	Increased cytokine secretion and cPLA(2) and Cox-2 levels in Snca-/- microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment.	1-Butanol	148-157	prostaglandin-endoperoxide synthase 2	Mus musculus	45-50
21384098-4	2011	Increased cytokine secretion and cPLA(2) and Cox-2 levels in Snca-/- microglia were partially attenuated by inhibiting PLD-dependent signaling with n-butanol treatment.	1-Butanol	148-157	synuclein, alpha	Mus musculus	61-65
22163350-3	2011	Our results revealed that in leaves treated with n-butanol, a potent inhibitor of phosphatidic acid (PA) synthesis catalyzed by phospholipase D, a significant decrease of ZmCPK11 activity was observed, indicating contribution of PA in the kinase activation.	1-Butanol	49-58	phospholipase D alpha 1	Zea mays	128-143
20158570-5	2011	Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst.	1-Butanol	6-15	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	19-22
20158570-5	2011	Using 1-butanol, a PLD substrate, to block phosphatidic acid (PA) generation, the PMA-stimulated neutrophil respiratory burst was also partially inhibited, further indicating that PLD activation, possibly its hydrolytic product PA and diacylglycerol (DAG), is involved in PMA-stimulated respiratory burst.	1-Butanol	6-15	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	180-183
21212180-8	2011	RESULTS: 1-Butanol increased Cch-stimulated protein secretion and decreased ERK activity.	1-Butanol	9-18	Eph receptor B1	Rattus norvegicus	76-79
21212180-12	2011	PMA-stimulated ERK activity was also inhibited by 1-butanol.	1-Butanol	50-59	Eph receptor B1	Rattus norvegicus	15-18
20417698-2	2010	n-Butanol (0.5%) inhibited PLD activation, attenuated cell injury at 5 min of H(2)O(2) exposure, but enhanced injury at 3h of exposure.	1-Butanol	0-9	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
21203441-7	2010	While phosphatidic acid (PA)-mediated activation of mTOR, as revealed by drastic reduction in reporter expression by n-butanol, primarily contributed to the high level expression in PC3, multiple pathways involving PA, PI3K/Akt and ERK1/2 appear to contribute to the abundant reporter expression in 293T.	1-Butanol	117-126	mechanistic target of rapamycin kinase	Homo sapiens	52-56
21203441-7	2010	While phosphatidic acid (PA)-mediated activation of mTOR, as revealed by drastic reduction in reporter expression by n-butanol, primarily contributed to the high level expression in PC3, multiple pathways involving PA, PI3K/Akt and ERK1/2 appear to contribute to the abundant reporter expression in 293T.	1-Butanol	117-126	actin related protein 1B	Homo sapiens	182-185
21203441-7	2010	While phosphatidic acid (PA)-mediated activation of mTOR, as revealed by drastic reduction in reporter expression by n-butanol, primarily contributed to the high level expression in PC3, multiple pathways involving PA, PI3K/Akt and ERK1/2 appear to contribute to the abundant reporter expression in 293T.	1-Butanol	117-126	AKT serine/threonine kinase 1	Homo sapiens	224-227
21203441-10	2010	Further, PC3 offers an advantage in that the level of expression of the protein can be regulated by simple addition of n-butanol to the culture medium.	1-Butanol	119-128	actin related protein 1B	Homo sapiens	9-12
20561556-4	2010	Recently an updated rat physiologically based pharmacokinetic (PBPK) model was published that relied on a description of MTBE and its metabolite tertiary-butyl alcohol (TBA) binding to alpha 2u-globulin, a male rat-specific protein.	1-Butanol	154-167	alpha2u globulin	Rattus norvegicus	185-202
20136621-6	2010	In additional extracts from 80% ethanol extract of APL, n-butanol (BuOH) extract displayed the most potent anti-inflammatory effects based on in vitro assay.	1-Butanol	56-65	neuraminidase 1	Mus musculus	51-54
20359546-4	2010	HEK293 cells expressing DDHD1 produced [(3)H]arachidonic acid-containing LPI after prelabeling with [(3)H]arachidonic acid and subsequent activation by ionomycin; the formation of [(3)H]LPI was inhibited by n-butanol and the overexpression of an inactive PLD1 mutant PLD1K898R.	1-Butanol	207-216	DDHD domain containing 1	Homo sapiens	24-29
20448441-3	2010	The dominant negative PLD1 inhibited glucose-induced Beta2 expression, and glucose-induced insulin secretion was blocked by treatment with 1-butanol or PLD1-siRNA.	1-Butanol	139-148	phospholipase D1	Mus musculus	22-26
19882733-0	2010	Barrier heights for H-atom abstraction by H*O2 from n-butanol--a simple yet exacting test for model chemistries?	1-Butanol	52-61	heme oxygenase 2	Homo sapiens	42-46
20136621-6	2010	In additional extracts from 80% ethanol extract of APL, n-butanol (BuOH) extract displayed the most potent anti-inflammatory effects based on in vitro assay.	1-Butanol	67-71	neuraminidase 1	Mus musculus	51-54
20136621-9	2010	Our findings suggest that the BuOH extract of APL shows a potential anti-inflammatory activity, substantiating its traditional use in medicine.	1-Butanol	30-34	neuraminidase 1	Mus musculus	46-49
19705363-6	2009	Ethanol, n-propanol, and n-butanol molecules interacted with the n-heptane molecule and resulted in cytochrome P450 spectral changes as well as alterations in the n-heptane metabolic profile.	1-Butanol	25-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-115
20112697-5	2009	1-Butanol, a PLD inhibitor, could completely block Akt phosphorylation in C2C12 cells that even stimulated by insulin.	1-Butanol	0-9	thymoma viral proto-oncogene 1	Mus musculus	51-54
19252318-4	2009	The ethyl acetate- and 1-butanol-soluble fractions also showed inhibitory effects on rat lens aldose reductase and scavenging effects on 1,1-diphenylpicryl-2-hydrazyl radical and superoxide.	1-Butanol	23-32	aldo-keto reductase family 1 member B1	Rattus norvegicus	94-110
19270017-0	2009	Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to alpha2u-globulin.	1-Butanol	88-101	alpha2u globulin	Rattus norvegicus	145-161
18358832-6	2008	Blocking the PLD signal by 1-butanol suppresses the proliferation.	1-Butanol	27-36	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
19064628-2	2009	PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes.	1-Butanol	57-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
19064628-2	2009	PLD production of PA is inhibited by the primary alcohol 1-butanol, which has thus been widely employed to identify PLD/PA-driven processes.	1-Butanol	57-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	116-119
18621911-5	2008	Furthermore, 1-butanol inhibited 5-HT activation of S6K1 and S6 protein, downstream effectors of mammalian target of rapamycin (mTOR), by 80 and 72%, respectively, and partially blocked activation of extracellular signal-regulated kinase (ERK) by 30% but had no effect on other associated signaling pathways.	1-Butanol	13-22	ribosomal protein S6 kinase B1	Homo sapiens	52-63
18621911-5	2008	Furthermore, 1-butanol inhibited 5-HT activation of S6K1 and S6 protein, downstream effectors of mammalian target of rapamycin (mTOR), by 80 and 72%, respectively, and partially blocked activation of extracellular signal-regulated kinase (ERK) by 30% but had no effect on other associated signaling pathways.	1-Butanol	13-22	mechanistic target of rapamycin kinase	Homo sapiens	97-126
18621911-5	2008	Furthermore, 1-butanol inhibited 5-HT activation of S6K1 and S6 protein, downstream effectors of mammalian target of rapamycin (mTOR), by 80 and 72%, respectively, and partially blocked activation of extracellular signal-regulated kinase (ERK) by 30% but had no effect on other associated signaling pathways.	1-Butanol	13-22	mechanistic target of rapamycin kinase	Homo sapiens	128-132
18621911-5	2008	Furthermore, 1-butanol inhibited 5-HT activation of S6K1 and S6 protein, downstream effectors of mammalian target of rapamycin (mTOR), by 80 and 72%, respectively, and partially blocked activation of extracellular signal-regulated kinase (ERK) by 30% but had no effect on other associated signaling pathways.	1-Butanol	13-22	mitogen-activated protein kinase 1	Homo sapiens	200-237
18621911-5	2008	Furthermore, 1-butanol inhibited 5-HT activation of S6K1 and S6 protein, downstream effectors of mammalian target of rapamycin (mTOR), by 80 and 72%, respectively, and partially blocked activation of extracellular signal-regulated kinase (ERK) by 30% but had no effect on other associated signaling pathways.	1-Butanol	13-22	mitogen-activated protein kinase 1	Homo sapiens	239-242
18621911-6	2008	Exogenous PA caused cellular proliferation and revitalized cyclin D1 expression by 5-HT of the 1-butanol-treated cells.	1-Butanol	95-104	cyclin D1	Homo sapiens	59-68
18498667-7	2008	PLD activity was assessed by measuring the formation of [3H]phosphatidylbutanol, the product of PLD-mediated transphosphatidylation, in the presence of n-butanol.	1-Butanol	152-161	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
18778076-7	2008	Low acetaldehyde availability together with enhanced hydroperoxide lyase and alcohol dehydrogenase levels in these fruits are suggested to have led to higher emission of 1-butanol and butyl esters.	1-Butanol	170-179	alcohol dehydrogenase	Malus domestica	77-98
18505819-5	2008	In Aplysia neurons, the inhibition of endogenous PA production by 1-butanol inhibited the physiological translocation of PKC Apl II by serotonin in the cell body and at the synapse but not the translocation of PKC Apl II-R273H.	1-Butanol	66-75	calcium-independent protein kinase C	Aplysia californica	125-131
18423386-6	2008	This response was inhibited by 1-butanol, a well known distracter of PLD activity, or upon overexpression of a dominant negative PLD2, and it was concomitant with a boost of PA/DAG production.	1-Butanol	31-40	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	69-72
18218859-3	2008	Preincubation of PMNL with the phospholipase D (PLD) inhibitor 1-butanol potently suppressed 5-LO product synthesis induced by the Ca(2)(+) ionophore A23187 or thapsigargin (TG) and blocked A23187-evoked translocation of 5-LO from the cytosol to the nuclear membrane, analyzed by subcellular fractionation as well as by indirect immunofluorescence microscopy.	1-Butanol	63-72	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	31-46
18218859-3	2008	Preincubation of PMNL with the phospholipase D (PLD) inhibitor 1-butanol potently suppressed 5-LO product synthesis induced by the Ca(2)(+) ionophore A23187 or thapsigargin (TG) and blocked A23187-evoked translocation of 5-LO from the cytosol to the nuclear membrane, analyzed by subcellular fractionation as well as by indirect immunofluorescence microscopy.	1-Butanol	63-72	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	48-51
18218859-6	2008	Moreover, coincubation of A23187- or TG-stimulated PMNL with OAG reversed inhibition of 5-LO product formation by 1-butanol in a concentration-dependent manner (EC(50), approximately 1 muM) and also restored 5-LO translocation.	1-Butanol	114-123	latexin	Homo sapiens	185-188
18004999-8	2008	Furthermore, phosphorylation of Pyk2, ERK, and CREB was suppressed by the PLD inhibitor, 1-butanol and transfection of PLD2 siRNA, whereas it was enhanced by over-expression of wild-type PLD2.	1-Butanol	89-98	protein tyrosine kinase 2 beta	Rattus norvegicus	32-36
18004999-8	2008	Furthermore, phosphorylation of Pyk2, ERK, and CREB was suppressed by the PLD inhibitor, 1-butanol and transfection of PLD2 siRNA, whereas it was enhanced by over-expression of wild-type PLD2.	1-Butanol	89-98	Eph receptor B1	Rattus norvegicus	38-41
18004999-8	2008	Furthermore, phosphorylation of Pyk2, ERK, and CREB was suppressed by the PLD inhibitor, 1-butanol and transfection of PLD2 siRNA, whereas it was enhanced by over-expression of wild-type PLD2.	1-Butanol	89-98	cAMP responsive element binding protein 1	Rattus norvegicus	47-51
18004999-8	2008	Furthermore, phosphorylation of Pyk2, ERK, and CREB was suppressed by the PLD inhibitor, 1-butanol and transfection of PLD2 siRNA, whereas it was enhanced by over-expression of wild-type PLD2.	1-Butanol	89-98	phospholipase D2	Rattus norvegicus	187-191
18165316-3	2008	Ethanol and 1-butanol inhibit L1-mediated cell-cell adhesion (L1 adhesion), whereas 1-octanol antagonizes this action.	1-Butanol	12-21	L1 cell adhesion molecule	Homo sapiens	30-32
18165316-3	2008	Ethanol and 1-butanol inhibit L1-mediated cell-cell adhesion (L1 adhesion), whereas 1-octanol antagonizes this action.	1-Butanol	12-21	L1 cell adhesion molecule	Homo sapiens	62-64
18344600-2	2008	The inhibitor of phospholipase D (PLD), n-butanol, completely blocked the migration and disturbed the characteristic localization of actin along the edge of lamellipodia.	1-Butanol	40-49	phospholipase D2	Rattus norvegicus	34-37
17936375-4	2008	Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER.	1-Butanol	104-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-52
17936375-4	2008	Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER.	1-Butanol	104-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
17936375-4	2008	Here, we show that the inhibition of phospholipase D (PLD)-mediated phosphatidic acid (PA) formation by 1-butanol inhibited the maturation and export of CFTR from the ER.	1-Butanol	104-113	CF transmembrane conductance regulator	Homo sapiens	153-157
17640750-5	2007	Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed CoCl(2)-induced COX-2 expression and PGE(2) formation.	1-Butanol	27-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89
17986621-4	2008	We found that hBD-2 mRNA up-regulation in human gingival epithelial cells (HGECs) by these two activators was mediated by PLD activation and blocked by ethanol and 1-butanol, PLD inhibitors.	1-Butanol	164-173	defensin beta 4A	Homo sapiens	14-19
17724165-8	2007	The addition of phosphatidic acid, a reaction product of PLD, partially restored fMLP-mediated transepithelial migration in the presence of 1-butanol but not the migration of Mac-1-deficient neutrophil-differentiated HL-60 cells.	1-Butanol	140-149	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	57-60
17724165-8	2007	The addition of phosphatidic acid, a reaction product of PLD, partially restored fMLP-mediated transepithelial migration in the presence of 1-butanol but not the migration of Mac-1-deficient neutrophil-differentiated HL-60 cells.	1-Butanol	140-149	formyl peptide receptor 1	Homo sapiens	81-85
17620283-6	2007	ERK1/2 activation was suppressed by the protein kinase C (PKC) inhibitors bisindolylmaleimide I and rottlerin, and by the phospholipase D inhibitor 1-butanol.	1-Butanol	148-157	mitogen activated protein kinase 3	Rattus norvegicus	0-6
17724165-5	2007	This up-regulation was dose-dependently prevented by incubation of neutrophils in 1-butanol, an inhibitor of PLD activity.	1-Butanol	82-91	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	109-112
17724165-7	2007	Incubation in 1-butanol did inhibit fMLP but not C5a-mediated migration across intestinal epithelial cell monolayers, showing that transepithelial migration to fMLP but not C5a is dependent on PLD.	1-Butanol	14-23	formyl peptide receptor 1	Homo sapiens	36-40
17724165-7	2007	Incubation in 1-butanol did inhibit fMLP but not C5a-mediated migration across intestinal epithelial cell monolayers, showing that transepithelial migration to fMLP but not C5a is dependent on PLD.	1-Butanol	14-23	formyl peptide receptor 1	Homo sapiens	160-164
17724165-7	2007	Incubation in 1-butanol did inhibit fMLP but not C5a-mediated migration across intestinal epithelial cell monolayers, showing that transepithelial migration to fMLP but not C5a is dependent on PLD.	1-Butanol	14-23	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	193-196
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	1-Butanol	57-66	tumor necrosis factor	Mus musculus	127-136
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	1-Butanol	57-66	prostaglandin-endoperoxide synthase 2	Mus musculus	143-148
18067784-6	2007	The petroleum ether fraction, ethyl acetate fraction and n-butanol fraction of ethanol extract could inhibit the production of TNF-alpha mRNA, COX-2 mRNA and NF-kappaB to some extent.	1-Butanol	57-66	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
17718500-4	2007	The recovery of cytochrome c from the organic phase is successfully achieved under acidic conditions using an appropriate amount of 1-butanol.	1-Butanol	132-141	cytochrome c, somatic	Homo sapiens	16-28
17065600-6	2007	Moreover, knockdown of PLD1 by siRNA and blockage of PLD by treatment with 0.3% 1-butanol decreased PRL/IGFBP1 mRNA expression, whereas PLD1 overexpression increased PRL/IGFBP1 mRNA expression.	1-Butanol	80-89	prolactin	Homo sapiens	100-103
17113740-10	2007	Administration of the MeOH extract and the BuOH fraction of Impatiens pritzellii decreased the spleen and thymus indexes, down-regulated the levels of IgG, INF-gamma, IL-18, and up-regulated the concentration of IL-10 in the serum of mice with CIA.	1-Butanol	43-47	interleukin 18	Mus musculus	156-172
17113740-10	2007	Administration of the MeOH extract and the BuOH fraction of Impatiens pritzellii decreased the spleen and thymus indexes, down-regulated the levels of IgG, INF-gamma, IL-18, and up-regulated the concentration of IL-10 in the serum of mice with CIA.	1-Butanol	43-47	interleukin 10	Mus musculus	212-217
17065600-6	2007	Moreover, knockdown of PLD1 by siRNA and blockage of PLD by treatment with 0.3% 1-butanol decreased PRL/IGFBP1 mRNA expression, whereas PLD1 overexpression increased PRL/IGFBP1 mRNA expression.	1-Butanol	80-89	insulin like growth factor binding protein 1	Homo sapiens	104-110
17065556-6	2007	Knockdown of endogenous clathrin heavy chain showed that the Golgi apparatus failed to reform efficiently after BFA or 1-butanol removal.	1-Butanol	119-128	clathrin heavy chain	Rattus norvegicus	24-44
16953116-6	2006	Pretreatment of the cells with 1-butanol, a PLD inhibitor, completely abrogated the LPC-induced inhibition of apoptosis and neurite outgrowth in PC12 cells overexpressing PLD2.	1-Butanol	31-40	phospholipase D2	Rattus norvegicus	171-175
17209515-0	2006	[Measurement of gene expression of CYP mRNA in liver of rats exposed to toluene and 1-butanol vapors].	1-Butanol	84-93	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	35-38
17179862-4	2006	The 3,5-dihydroxyphenylglycine-induced proliferation was inhibited in the presence of the metabotropic glutamate receptor 5 antagonist (2-methyl-6-(phenylethynyl)pyridine), the protein kinase C inhibitor GF109203X, brefeldin A and 1-butanol.	1-Butanol	231-240	glutamate metabotropic receptor 5	Homo sapiens	90-123
16501990-11	2006	1-Butanol, an inhibitor of phosphatidic acid (PA) production by phospholipase D (PLD), reduced NaCl- and NO-induced H(+)-ATPase activation.	1-Butanol	0-9	phospholipase D alpha 1	Zea mays	64-79
16236484-6	2006	Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB.	1-Butanol	94-103	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	69-72
16236484-6	2006	Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB.	1-Butanol	94-103	phospholipase D2	Homo sapiens	77-81
16236484-6	2006	Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB.	1-Butanol	94-103	purinergic receptor P2Y12	Homo sapiens	129-134
16236484-6	2006	Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB.	1-Butanol	94-103	RAP1A, member of RAS oncogene family	Homo sapiens	167-171
16236484-6	2006	Treatment of cells with the Ca2+ chelator BAPTA-AM and inhibition of Src and PLD2 with PP2 or 1-butanol, respectively, abrogated P2Y12 receptor-mediated activation of Rap1 and PKB.	1-Butanol	94-103	protein tyrosine kinase 2 beta	Homo sapiens	176-179
16501990-11	2006	1-Butanol, an inhibitor of phosphatidic acid (PA) production by phospholipase D (PLD), reduced NaCl- and NO-induced H(+)-ATPase activation.	1-Butanol	0-9	phospholipase D alpha 1	Zea mays	81-84
16882041-6	2006	We show that blocking PLD activity, by expressing Y112-LMP2A, treating cells with the PLD inhibitor 1-butanol or reducing PLD expression by siRNA, blocked BCR trafficking to class II-containing compartments.	1-Butanol	100-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	22-25
16882041-6	2006	We show that blocking PLD activity, by expressing Y112-LMP2A, treating cells with the PLD inhibitor 1-butanol or reducing PLD expression by siRNA, blocked BCR trafficking to class II-containing compartments.	1-Butanol	100-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-89
16882041-6	2006	We show that blocking PLD activity, by expressing Y112-LMP2A, treating cells with the PLD inhibitor 1-butanol or reducing PLD expression by siRNA, blocked BCR trafficking to class II-containing compartments.	1-Butanol	100-109	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	86-89
16520553-5	2006	Elevated expression of CKII or PLD increased cell proliferation but pretreatment of cells with 1-butanol suppressed CKII-induced cell proliferation.	1-Butanol	95-104	casein kinase 2 alpha 1	Homo sapiens	116-120
17048570-8	2006	CONCLUSION: S. tamariscina and it"s water part and n-butanol part have estrogenic activities, effect on ERbeta is greater than ERalpha.	1-Butanol	51-60	estrogen receptor 2 (beta)	Mus musculus	104-110
16507568-2	2006	The single chain variable region fragment of antibody 2F3 (scFv2F3) was elicited against hapten GSH-S-DN2phBu, a conjugate of glutathione (GSH), butyl alcohol, and 1-chloro-2,4-dinitrobenzene (CDNB); it can therefore bind both GSH and CDNB, the substrates of native glutathione S-transferases (GSTs).	1-Butanol	145-158	glutathione synthetase	Rattus norvegicus	96-101
16113073-8	2006	ANG II-induced PLD activity was inhibited by the primary alcohol n-butanol but not the tertiary alcohol t-butanol.	1-Butanol	65-74	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	15-18
16449385-4	2006	Conversely, inhibition of PLD1 activity by 1-butanol decreases betaAPP trafficking in both wt and PS1-deficient cells.	1-Butanol	43-52	phospholipase D1	Homo sapiens	26-30
16449385-4	2006	Conversely, inhibition of PLD1 activity by 1-butanol decreases betaAPP trafficking in both wt and PS1-deficient cells.	1-Butanol	43-52	presenilin 1	Homo sapiens	98-101
15705590-3	2005	The H(2)O(2)-induced phosphorylation of two Pyk2 sites (Tyr(580), and Tyr(881)) was suppressed by 1-butanol, an inhibitor of transphosphatidylation by PLD, and also by transfection of catalytically negative mouse PLD2K758R (PLD2KR).	1-Butanol	98-107	PTK2 protein tyrosine kinase 2 beta	Mus musculus	44-48
16280360-4	2006	Remarkably, all of these phenotypes, including accumulated tubular endosomes, blocked recycling, and failure to make protrusions and recruit ACAP effectively, could be recreated in either untransfected cells or cells expressing wild-type Arf6 by treatment with 1-butanol to inhibit the formation of phosphatidic acid (PA), the product of PLD.	1-Butanol	261-270	ADP ribosylation factor 6	Homo sapiens	238-242
16280360-4	2006	Remarkably, all of these phenotypes, including accumulated tubular endosomes, blocked recycling, and failure to make protrusions and recruit ACAP effectively, could be recreated in either untransfected cells or cells expressing wild-type Arf6 by treatment with 1-butanol to inhibit the formation of phosphatidic acid (PA), the product of PLD.	1-Butanol	261-270	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	338-341
16333570-6	2005	1-Butanol, an antagonist of PLD-dependent phosphatidic acid production, was reported to induce defects in Arabidopsis seedling development that were somewhat similar to effects induced by elevated levels of NAE.	1-Butanol	0-9	phospholipase D alpha 1	Arabidopsis thaliana	28-31
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	1-Butanol	103-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	89-92
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	1-Butanol	103-112	ATP binding cassette subfamily A member 1	Homo sapiens	171-176
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	1-Butanol	103-112	ATP binding cassette subfamily A member 1	Homo sapiens	236-241
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	1-Butanol	103-112	phospholipase D2	Homo sapiens	281-285
16118212-6	2005	Unsaturated but not saturated fatty acids stimulated phospholipase D (PLD) activity, the PLD inhibitor 1-butanol prevented the unsaturated fatty acid-induced reduction in ABCA1 levels, and the PLD2 activator mastoparan markedly reduced ABCA1 protein levels, implicating a role for PLD2 in the ABCA1 destabilizing effects of fatty acids.	1-Butanol	103-112	ATP binding cassette subfamily A member 1	Homo sapiens	236-241
15919668-7	2005	The PDGF-BB-induced activation of growth signaling was also suppressed by 1-butanol, which prevents the production of phosphatidic acid by phospholipase D (but not by t-butyl alcohol), thereby implicating PLD2 in PDGF-BB-mediated signaling in TC-135 cells.	1-Butanol	74-83	phospholipase D2	Homo sapiens	205-209
15843515-8	2005	Phorbol ester, which did not stimulate degranulation by itself, restored degranulation when used in combination with thapsigargin whether PLD function was disrupted with 1-butanol or the small inhibitory RNAs.	1-Butanol	170-179	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	138-141
16716806-5	2006	To examine the regulation mechanism of PMA and Se-MSC on CD11c gene expression through the activation of PLD1, we analyzed changes in the CD11c mRNA level and the promoter activity following treatment of a selective PLD inhibitor n-butanol.	1-Butanol	230-239	integrin subunit alpha X	Homo sapiens	57-62
16716806-5	2006	To examine the regulation mechanism of PMA and Se-MSC on CD11c gene expression through the activation of PLD1, we analyzed changes in the CD11c mRNA level and the promoter activity following treatment of a selective PLD inhibitor n-butanol.	1-Butanol	230-239	phospholipase D1	Homo sapiens	105-109
16716806-5	2006	To examine the regulation mechanism of PMA and Se-MSC on CD11c gene expression through the activation of PLD1, we analyzed changes in the CD11c mRNA level and the promoter activity following treatment of a selective PLD inhibitor n-butanol.	1-Butanol	230-239	integrin subunit alpha X	Homo sapiens	138-143
16716806-5	2006	To examine the regulation mechanism of PMA and Se-MSC on CD11c gene expression through the activation of PLD1, we analyzed changes in the CD11c mRNA level and the promoter activity following treatment of a selective PLD inhibitor n-butanol.	1-Butanol	230-239	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	105-108
16716806-6	2006	The combinatory effect of PMA and Se-MSC on CD11c gene expression was abolished by n-butanol in a dose-dependent manner.	1-Butanol	83-92	integrin subunit alpha X	Homo sapiens	44-49
15820219-0	2005	Inhibition of erythrocyte acetylcholinesterase by n-butanol at high concentrations.	1-Butanol	50-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
15820219-2	2005	The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol.	1-Butanol	47-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65
15820219-2	2005	The indication of a direct interaction between n-butanol and AChE molecules is the activation/inhibition of AChE by occupation of the enzyme"s active and/or regulatory sites by alcohol.	1-Butanol	47-56	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
15820219-4	2005	In this work the mechanism of inhibition of erythrocyte AChE by n-butanol at high concentrations was studied.	1-Butanol	64-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
15820219-6	2005	From the values of the inhibition constants it was concluded that at high n-butanol concentrations two alcohol molecules usually interact with AChE.	1-Butanol	74-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	143-147
15705590-5	2005	H(2)O(2)-induced phosphorylation of Akt and p70S6K was dependent on phosphatidylinositol 3-kinase (PI3K) activity and was abolished by 1-butanol but not t-butanol.	1-Butanol	135-144	AKT serine/threonine kinase 1	Rattus norvegicus	36-39
15705590-5	2005	H(2)O(2)-induced phosphorylation of Akt and p70S6K was dependent on phosphatidylinositol 3-kinase (PI3K) activity and was abolished by 1-butanol but not t-butanol.	1-Butanol	135-144	ribosomal protein S6 kinase B1	Rattus norvegicus	44-50
15525798-2	2005	Ang II-induced Akt phosphorylation was significantly reduced by the PLD inhibitor 1-butanol, but not by its inactive analog 2-butanol, and by brefeldin A, an inhibitor of the PLD cofactor ADP-ribosylation factor, and in cells infected with retrovirus containing PLD(2) siRNA or transfected with PLD(2) antisense but not control LacZ or sense oligonucleotide.	1-Butanol	82-91	angiotensinogen	Rattus norvegicus	0-6
15657063-4	2005	We found that acidic pHe (5.9) activated phospholipase D (PLD), and inhibition of PLD activity by 1-butanol and Myr-ARF6 suppressed the acidic pHe-induced MMP-9 expression.	1-Butanol	98-107	matrix metallopeptidase 9	Mus musculus	155-160
15525798-2	2005	Ang II-induced Akt phosphorylation was significantly reduced by the PLD inhibitor 1-butanol, but not by its inactive analog 2-butanol, and by brefeldin A, an inhibitor of the PLD cofactor ADP-ribosylation factor, and in cells infected with retrovirus containing PLD(2) siRNA or transfected with PLD(2) antisense but not control LacZ or sense oligonucleotide.	1-Butanol	82-91	AKT serine/threonine kinase 1	Rattus norvegicus	15-18
15525798-4	2005	Ang II-induced EGFR phosphorylation was inhibited by 1-butanol and PLD(2) siRNA and also by cPLA(2) siRNA.	1-Butanol	53-62	angiotensinogen	Rattus norvegicus	0-6
15525798-4	2005	Ang II-induced EGFR phosphorylation was inhibited by 1-butanol and PLD(2) siRNA and also by cPLA(2) siRNA.	1-Butanol	53-62	epidermal growth factor receptor	Rattus norvegicus	15-19
15556619-6	2004	TPA-induced differentiation was inhibited by 1-butanol, confirming the involvement of PLD in this effect.	1-Butanol	45-54	plasminogen activator, tissue type	Homo sapiens	0-3
15616193-3	2005	Addition of 1-butanol, which selectively inhibits PA production by PLD, markedly decreased AVP-induced myogenesis.	1-Butanol	12-21	arginine vasopressin	Rattus norvegicus	91-94
15708682-5	2005	Results showed that 11.7% 1-butanol, 76.9 mM sodium dodecyl sulphate (SDS), pH of 6.73 and a flow rate of 1.35 ml min(-1) are the best conditions for separation of these compounds.	1-Butanol	26-35	CD59 molecule (CD59 blood group)	Homo sapiens	114-120
15325847-6	2004	n-butanol, a well-known phosphatidic acid (PA) acceptor, completely inhibited WKYMVm-induced STAT3 serine phosphorylation.	1-Butanol	0-9	signal transducer and activator of transcription 3	Homo sapiens	93-98
15470141-9	2004	The constitutive internalization of mGluR1a and mGluR5a is also attenuated by the treatment of cells with 1-butanol to prevent PLD2-mediated phosphatidic acid formation.	1-Butanol	106-115	glutamate receptor, ionotropic, kainate 1	Mus musculus	48-54
15470141-9	2004	The constitutive internalization of mGluR1a and mGluR5a is also attenuated by the treatment of cells with 1-butanol to prevent PLD2-mediated phosphatidic acid formation.	1-Butanol	106-115	phospholipase D2	Homo sapiens	127-131
15325847-9	2004	This WKYMVm-induced ERK activation was inhibited by n-butanol, whereas ERK activation was also induced by the addition of exogenous PA.	1-Butanol	52-61	mitogen-activated protein kinase 1	Homo sapiens	20-23
14720217-4	2004	We clearly demonstrated that inhibition of PLD2-mediated phosphatidic acid formation by alcohol (1-butanol or ethanol) or overexpression of a dominant negative mutant of PLD2 prevented agonist-mediated endocytosis and resulted in a faster desensitization rate of the mu-opioid receptor after chronic (D-Ala2, Me Phe4, Glyol5)enkephalin treatment in human embryonic kidney 293 cells.	1-Butanol	97-106	phospholipase D2	Homo sapiens	43-47
15330104-8	2004	When MPs of D-SUV were utilized for chiral separation, 1.00% (w/w) 1-butanol and 3.50% (w/w) 1-butanol was optimum for enantioseparation of (+/-)-BNP and (+/-)-BOH, respectively.	1-Butanol	67-76	natriuretic peptide B	Homo sapiens	146-149
15330104-8	2004	When MPs of D-SUV were utilized for chiral separation, 1.00% (w/w) 1-butanol and 3.50% (w/w) 1-butanol was optimum for enantioseparation of (+/-)-BNP and (+/-)-BOH, respectively.	1-Butanol	93-102	natriuretic peptide B	Homo sapiens	146-149
15210717-4	2004	Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed EGCG-induced COX-2 expression and PGE synthesis.	1-Butanol	27-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
15255942-4	2004	1-Butanol, which is a substrate for PLD and inhibits PA formation, inhibited carbachol-induced cell proliferation and the underlying intracellular signaling, whereas its analog tert-butanol, which is a poor substrate for PLD, was much less effective.	1-Butanol	0-9	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
15147910-2	2004	To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates.	1-Butanol	94-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
15147910-2	2004	To investigate the role of PLD during the regulatory volume decrease, cells were treated with 1-butanol resulting in a depletion of PLD substrates.	1-Butanol	94-103	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	132-135
14704231-4	2004	A PLD inhibitor, 1-butanol, almost completely suppressed VEGF-induced ERK phosphorylation and cellular proliferation, whereas the negative control for 1-butanol, 3-butanol, did not produce significant changes.	1-Butanol	17-26	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	2-5
14704231-4	2004	A PLD inhibitor, 1-butanol, almost completely suppressed VEGF-induced ERK phosphorylation and cellular proliferation, whereas the negative control for 1-butanol, 3-butanol, did not produce significant changes.	1-Butanol	17-26	vascular endothelial growth factor A	Homo sapiens	57-61
14704231-4	2004	A PLD inhibitor, 1-butanol, almost completely suppressed VEGF-induced ERK phosphorylation and cellular proliferation, whereas the negative control for 1-butanol, 3-butanol, did not produce significant changes.	1-Butanol	17-26	mitogen-activated protein kinase 1	Homo sapiens	70-73
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	formyl peptide receptor 1	Homo sapiens	17-21
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	29-32
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	formyl peptide receptor 1	Homo sapiens	97-101
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	myeloperoxidase	Homo sapiens	157-160
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	formyl peptide receptor 1	Homo sapiens	97-101
15294123-6	2004	In 1-butanol+LPS+fMLP group, PLD activity of preoperative neutrophils was lower than that in LPS+fMLP group (P<0.01), besides the release of elastase and MPO decreased sharply below both LPS+fMLP and fMLP groups (P<0.01).	1-Butanol	3-12	formyl peptide receptor 1	Homo sapiens	97-101
15294123-11	2004	Notably, PLD activity was even nonstatistically lower in 1-butanol+LPS+fMLP group than that in LPS or fMLP group.	1-Butanol	57-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	9-12
15294123-11	2004	Notably, PLD activity was even nonstatistically lower in 1-butanol+LPS+fMLP group than that in LPS or fMLP group.	1-Butanol	57-66	formyl peptide receptor 1	Homo sapiens	71-75
14967244-4	2004	For the monohydric alcohols used in this study (methanol, ethanol, 1-propanol, n-butanol, iso-butanol and trifluoroethanol), B22 for lysozyme reaches a common plateau at approximately 5% (v/v) alcohol, while glycerol increases B22 more than monohydric alcohols.	1-Butanol	79-88	lysozyme	Homo sapiens	133-141
14769825-3	2004	We studied the role of PLD in the phosphorylation of p70(S6K) and 4E-BP1 induced by lysophosphatidic acid (LPA) and platelet-derived growth factor (PDGF) using fibroblasts deficient in PLD activity and also 1-butanol, which inhibits phosphatidic acid production by PLD.	1-Butanol	207-216	ribosomal protein S6 kinase B1	Homo sapiens	53-56
14969348-2	2004	The n-butanol fraction from the water extract of the stems, when pretreated orally at 200 mg/kg/day for 7 consecutive days in rats, was demonstrated to exhibit significant increases in antioxidant enzyme activities such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase by 30.31, 19.82 and 155%, respectively.	1-Butanol	4-13	catalase	Rattus norvegicus	263-271
14704130-8	2004	Sensitized RPMC were treated with 1 % 1-butanol or 2,3- disphosphoglycerate 10 mmol/L before challenge with ovalbumin, these drugs induced an inhibition of PLD activity and a reduction of beta-hexosaminidase release to basal level.	1-Butanol	38-47	O-GlcNAcase	Rattus norvegicus	188-207
14528019-9	2004	Spo14p-generated PtdOH appears to have an essential role in sporulation, because treatment of cells with 1-butanol, which supports Spo14p-catalyzed PtdCho breakdown but leads to production of Cho and Ptd-butanol, blocks spore formation at concentrations where the inert isomer, 2-butanol, has little effect.	1-Butanol	105-114	phospholipase D	Saccharomyces cerevisiae S288C	0-6
15533005-8	2004	An evaluation of the relation between the share of the fraction extracted with n-butanol from the different types of sludge and the properties of the PAHs showed that statistically, there existed significant (P < 0.05) correlations between log Koc (in the case of one sewage sludge) and between the nitrogen content, the ratio of C/N, cations Mg2+ and K+ (in the case of a few PAHs).	1-Butanol	79-88	insulin like growth factor 2 mRNA binding protein 3	Homo sapiens	247-250
14528019-9	2004	Spo14p-generated PtdOH appears to have an essential role in sporulation, because treatment of cells with 1-butanol, which supports Spo14p-catalyzed PtdCho breakdown but leads to production of Cho and Ptd-butanol, blocks spore formation at concentrations where the inert isomer, 2-butanol, has little effect.	1-Butanol	105-114	phospholipase D	Saccharomyces cerevisiae S288C	131-137
14613874-10	2003	Inhibition of PLD-mediated phosphatidic acid (PA) formation by 1% 1-butanol abolished AngII-induced COX-2 expression and PGI(2) secretion, while dioctanoyl PA increased COX-2 expression and PGI(2) production in a time- and concentration-dependent manner.	1-Butanol	66-75	angiotensinogen	Rattus norvegicus	86-91
14613874-10	2003	Inhibition of PLD-mediated phosphatidic acid (PA) formation by 1% 1-butanol abolished AngII-induced COX-2 expression and PGI(2) secretion, while dioctanoyl PA increased COX-2 expression and PGI(2) production in a time- and concentration-dependent manner.	1-Butanol	66-75	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	100-105
12935885-7	2003	Incubation of cells with 1-butanol to inhibit PLD signaling attenuated PE-induced phosphorylation of mTOR, 4E-BP1 and p70 S6 kinase.	1-Butanol	25-34	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
12935885-7	2003	Incubation of cells with 1-butanol to inhibit PLD signaling attenuated PE-induced phosphorylation of mTOR, 4E-BP1 and p70 S6 kinase.	1-Butanol	25-34	mechanistic target of rapamycin kinase	Homo sapiens	101-105
12935885-7	2003	Incubation of cells with 1-butanol to inhibit PLD signaling attenuated PE-induced phosphorylation of mTOR, 4E-BP1 and p70 S6 kinase.	1-Butanol	25-34	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	107-113
15562719-3	2002	RESULTS: The n-butanol fraction obviously inhibited the proliferation of spleen lymphocytes induced by LPS, bilaterally regulated the T lymphocyte proliferation induced by ConA.	1-Butanol	13-22	toll-like receptor 4	Mus musculus	103-106
12890486-7	2003	Moreover, PLD inhibitor, 1-butanol, inhibited Ang1-induced endothelial cell migration.	1-Butanol	25-34	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	10-13
12890486-7	2003	Moreover, PLD inhibitor, 1-butanol, inhibited Ang1-induced endothelial cell migration.	1-Butanol	25-34	angiopoietin 1	Homo sapiens	46-50
12782152-8	2003	Formation of phosphatidylbutanol (PtdBut) at the expense of phosphatidic acid (PtdH) in the presence of n-butanol inhibited ERK1 activation and c-fos mRNA expression in PDGF-BB-treated Cl8 cells.	1-Butanol	104-113	rolled	Drosophila melanogaster	124-128
12782152-8	2003	Formation of phosphatidylbutanol (PtdBut) at the expense of phosphatidic acid (PtdH) in the presence of n-butanol inhibited ERK1 activation and c-fos mRNA expression in PDGF-BB-treated Cl8 cells.	1-Butanol	104-113	kayak	Drosophila melanogaster	144-149
12782152-9	2003	ERK activation by PMA was unaffected by n-butanol in Cl8 cells but almost abolished by n-butanol in Cl8 HAbetaC2-1 cells, showing that ERK activation by PMA is heavily dependent on PKC and PLD1.	1-Butanol	87-96	rolled	Drosophila melanogaster	0-3
12782152-9	2003	ERK activation by PMA was unaffected by n-butanol in Cl8 cells but almost abolished by n-butanol in Cl8 HAbetaC2-1 cells, showing that ERK activation by PMA is heavily dependent on PKC and PLD1.	1-Butanol	87-96	rolled	Drosophila melanogaster	135-138
12782152-9	2003	ERK activation by PMA was unaffected by n-butanol in Cl8 cells but almost abolished by n-butanol in Cl8 HAbetaC2-1 cells, showing that ERK activation by PMA is heavily dependent on PKC and PLD1.	1-Butanol	87-96	Protein C kinase 53E	Drosophila melanogaster	181-184
12782152-9	2003	ERK activation by PMA was unaffected by n-butanol in Cl8 cells but almost abolished by n-butanol in Cl8 HAbetaC2-1 cells, showing that ERK activation by PMA is heavily dependent on PKC and PLD1.	1-Butanol	87-96	Phospholipase D	Drosophila melanogaster	189-193
12881496-0	2003	The effects of the phospholipase D-antagonist 1-butanol on seedling development and microtubule organisation in Arabidopsis.	1-Butanol	46-55	phospholipase D alpha 1	Arabidopsis thaliana	19-34
12881496-3	2003	(2001) Plant Cell 13: 2143], we exposed seeds and young seedlings of Arabidopsis to 1-butanol, a specific inhibitor of PLD-dependent production of the signalling molecule phosphatidic acid (PA).	1-Butanol	84-93	phospholipase D alpha 1	Arabidopsis thaliana	119-122
12576204-5	2003	The n-butanol fraction was the strongest in the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in CCl(4)-intoxicated rats.	1-Butanol	4-13	catalase	Rattus norvegicus	139-147
12576204-7	2003	Especially, the n-butanol extract was found to cause significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities as well as a significant decrease in the MDA production.	1-Butanol	16-25	catalase	Rattus norvegicus	107-115
12685351-1	2002	OBJECTIVE: To study the effects of n-butanol fraction from the whole plants (Lysimachia hemsleyana) on the phagocytic activities of the peritoneal macrophage, production of interleukin-2.	1-Butanol	35-44	interleukin 2	Mus musculus	173-186
12685351-2	2002	METHODS: We extracted the components with ethanol, acetic ether, n-butanol and chloroform, then studied the n-butanol fraction on the phagocytic activities of the peritoneal macrophage, production of interleukin-2 (IL-2) from splenocytes induced by ConA in mice in vitro.	1-Butanol	108-117	interleukin 2	Mus musculus	200-213
12685351-3	2002	RESULTS: n-Butanol fraction of an ethanol extract of air-dried herbs bilaterally regulated the IL-2 production from splenocytes induced by ConA, and enhanced the phagocytic activities of activated mouse peritoneal macrophages.	1-Butanol	9-18	interleukin 2	Mus musculus	95-99
12039947-7	2002	Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-stimulated IL-8 production by 1-butanol further strengthened this observation.	1-Butanol	82-91	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
11854442-4	2002	Moreover, the treatment of [(3)H]myristate-labeled cells in the presence of 1-butanol caused the dose-dependent formation of [(3)H]phosphatidylbutanol (PBt), a product specific to PLD activity.	1-Butanol	76-85	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	180-183
12023367-4	2002	These processes and secretion of granules are suppressed by expression of a catalytically inactive mutant of PLD1 or by the presence of 50 mM 1-butanol but not tert-butanol, an indication that these events are dependent on the catalytic activity of PLD1.	1-Butanol	142-151	phospholipase D1	Rattus norvegicus	109-113
12023367-4	2002	These processes and secretion of granules are suppressed by expression of a catalytically inactive mutant of PLD1 or by the presence of 50 mM 1-butanol but not tert-butanol, an indication that these events are dependent on the catalytic activity of PLD1.	1-Butanol	142-151	phospholipase D1	Rattus norvegicus	249-253
11906165-4	2002	During established [Ca(2+)](i) oscillations induced by 1 microM histamine, 0.3% n-butanol, which "functionally" redirects phosphatidic acid formed by PLD to PBt, decreased [Ca(2+)](i) oscillation frequency by approximately 50% and produced a similar reduction in NF-kappaB activity.	1-Butanol	80-89	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	150-153
12198859-2	2002	Incorporation of 2% 1-butanol, 1% 1,2-hexanediol, or 0.25% 1,2-octanediol into an aqueous mobile phase greatly improved the separation of alkane carboxylic acids on a silica C18 column, both in terms of separation time and peak shape.	1-Butanol	20-29	Bardet-Biedl syndrome 9	Homo sapiens	174-177
11854442-5	2002	Pretreating the cells with 1-butanol and Ro 31-8220 inhibited the IL-1 beta-induced COX-2 expression, but 3-butanol did not affect this response.	1-Butanol	27-36	interleukin 1 beta	Homo sapiens	66-75
11854442-5	2002	Pretreating the cells with 1-butanol and Ro 31-8220 inhibited the IL-1 beta-induced COX-2 expression, but 3-butanol did not affect this response.	1-Butanol	27-36	prostaglandin-endoperoxide synthase 2	Homo sapiens	84-89
11078731-12	2001	Moreover, the pretreatment of neutrophils with 1-butanol decreased Fgr activity in cells stimulated with formyl-methionyl-leucyl phenylalanine plus dihydrocytochalasin B.	1-Butanol	47-56	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	67-70
11704678-7	2002	ABI5-mediated transactivation was inhibited by overexpression of abi1-1, the dominant-negative allele of the protein phosphatase ABI1, and by 1-butanol, a competitive inhibitor of phospholipase D involved in ABA signaling.	1-Butanol	142-151	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	0-4
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	mitogen-activated protein kinase 14	Homo sapiens	44-47
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	interferon induced protein 44	Homo sapiens	52-55
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	cyclin dependent kinase 20	Homo sapiens	56-59
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	formyl peptide receptor 1	Homo sapiens	206-210
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	mitogen-activated protein kinase 14	Homo sapiens	219-222
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	interferon induced protein 44	Homo sapiens	254-257
11427526-3	2001	Western blot analysis using phosphospecific p38 and p44/p42 mitogen-activated protein kinase antibodies showed that increasing concentrations of ethanol or 1-butanol but not 2-butanol (0.05-0.5%) inhibited fMLP-induced p38 activation but did not inhibit p44/p42 activation.	1-Butanol	156-165	cyclin dependent kinase 20	Homo sapiens	258-261
11516724-3	2001	We examined the ability of prostaglandin H synthase (PHS) to activate AA to metabolites forming DNA adducts with the nuclease P1 and 1-butanol extraction enrichment procedure of the (32)P-postlabeling assay.	1-Butanol	133-142	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	27-51
11516724-3	2001	We examined the ability of prostaglandin H synthase (PHS) to activate AA to metabolites forming DNA adducts with the nuclease P1 and 1-butanol extraction enrichment procedure of the (32)P-postlabeling assay.	1-Butanol	133-142	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	53-56
11428671-4	2001	The potentiating activity of NGF-action was observed in the ethyl acetate and n-butanol fractions.	1-Butanol	78-87	nerve growth factor	Rattus norvegicus	29-32
11428671-5	2001	The n-butanol fraction was separated by silica gel chromatography, monitoring the NGF-potentiating activity to give gelsemiol and 9-hydroxysemperoside aglucone (9-OHSA).	1-Butanol	4-13	nerve growth factor	Rattus norvegicus	82-85
11439134-5	2001	When PA production is inhibited with n-butanol, an inhibitor of phospholipase D, the wound-induced activation of the MAPK is suppressed, suggesting that an elevation in PA levels is essential for its activation.	1-Butanol	37-46	MAPK	Glycine max	117-121
11245595-6	2001	The transphosphatidylation reaction in the presence of the primary alcohol 1-butanol [leading to stable phosphatidylbutanol (Pbut) formation] was used to measure activity of PLD.	1-Butanol	75-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	174-177
11243883-4	2001	Moreover, accumulation of phosphatidic acid (PA), a product of PLD action, potentiated the LPA-induced ERK activation in GP-PLD1 cells while blocking of PA production with the treatment of 1-butanol attenuated LPA-induced ERK phosphorylation.	1-Butanol	189-198	mitogen-activated protein kinase 1	Mus musculus	222-225
11154852-9	2000	Taken together, our results suggest that ethanol and 1-butanol exert a specific inhibitory effect on PKC-dependent astroglial cell proliferation by synergistically inhibiting PKC activity and the PLD signaling pathway.	1-Butanol	53-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	196-199
10931844-8	2000	PLD inhibitors 1-butanol and 2, 3-diphosphoglycerate, or the ARF6(N48R) mutant assumed to be defective in PLD activation, blocked fMLP-elicited oxidase activity in transfected cells.	1-Butanol	15-24	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
10931844-8	2000	PLD inhibitors 1-butanol and 2, 3-diphosphoglycerate, or the ARF6(N48R) mutant assumed to be defective in PLD activation, blocked fMLP-elicited oxidase activity in transfected cells.	1-Butanol	15-24	formyl peptide receptor 1	Homo sapiens	130-134
10582613-6	1999	Platelet-derived growth factor and endothelin-1 mimicked the mitogenic effect of FCS; their effects were also inhibited by the butanols in the potency order 1-butanol > 2-butanol > tert-butanol.	1-Butanol	157-166	endothelin 1	Rattus norvegicus	35-47
11079373-3	2000	We observed a marked increase in ALP activity in the serum of rats given a benzimidazole derivative by gavage, and detected it as slow-migrating ALPs (SM-ALPs), which were mALP-like but resistant to PIPLC and n-butanol treatment on disc PAGE.	1-Butanol	209-218	alopecia, recessive	Mus musculus	33-36
10986013-10	2000	In addition, the TMCH- and fMLP-induced DCF fluorescence, after the preincubation with the phospholipase D modulator n-butanol, was lowered by 83 and 52%, respectively.	1-Butanol	117-126	formyl peptide receptor 1	Homo sapiens	27-31
11018469-6	2000	As a supporting experiment, we inhibited PMA-stimulated PtdH formation by PLD, and also putatively PtdH-derived DAG, in Cl8 cells with 1-butanol.	1-Butanol	135-144	Phospholipase D	Drosophila melanogaster	74-77
10860542-9	2000	However, fMLP-mediated AA release was reduced by approximately 45% by Clostridium difficile toxin B (10 ng/ml) or by 1-butanol; both block phospholipase D (PLD) activity.	1-Butanol	117-126	formyl peptide receptor 1	Homo sapiens	9-13
10860542-9	2000	However, fMLP-mediated AA release was reduced by approximately 45% by Clostridium difficile toxin B (10 ng/ml) or by 1-butanol; both block phospholipase D (PLD) activity.	1-Butanol	117-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	156-159
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	Bud8p	Saccharomyces cerevisiae S288C	106-110
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	phosphatidylinositol-3-phosphate-binding protein BEM1	Saccharomyces cerevisiae S288C	112-116
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	Bem4p	Saccharomyces cerevisiae S288C	118-122
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	methionine--tRNA ligase MSM1	Saccharomyces cerevisiae S288C	159-163
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	mitochondrial 37S ribosomal protein MRP21	Saccharomyces cerevisiae S288C	165-170
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	ATP-dependent 3'-5' DNA helicase	Saccharomyces cerevisiae S288C	176-180
10637301-7	2000	A screen for 1-butanol-insensitive mutants identified additional proteins that regulate polarized growth (BUD8, BEM1, BEM4, and FIG1), mitochondrial function (MSM1, MRP21, and HMI1), and a transcriptional regulator (CHD1).	1-Butanol	13-22	chromatin-remodeling ATPase CHD1	Saccharomyces cerevisiae S288C	216-220
10088607-6	1999	The peptide-induced bacteria killing activity shares regulatory mechanisms for PLD activation with the superoxide generation, which is inhibited in the presence of 1-butanol.	1-Butanol	164-173	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
10518598-6	1999	Application of 1-butanol (1-buOH), a selective inhibitor of PtdOH production by PLD, inhibited the increase in PtdOH production elicited by ABA.	1-Butanol	15-24	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	80-83
15819102-3	1999	N-butanol (toluene:n-butanol 1:1) was added to toluene extractive solution of BRB2 x TBF.	1-Butanol	19-28	bradykinin receptor B2	Homo sapiens	78-82
10367351-2	1999	The capacity of the straight chain primary alcohols (methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol) to release the enzymes glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH) and glutamate dehydrogenase (GLDH) into the perfusate was strongly correlated with their carbon chain length.	1-Butanol	84-93	glutamic--pyruvic transaminase	Rattus norvegicus	133-164
10367351-2	1999	The capacity of the straight chain primary alcohols (methanol, ethanol, 1-propanol, 1-butanol and 1-pentanol) to release the enzymes glutamate-pyruvate transaminase (GPT), lactate dehydrogenase (LDH) and glutamate dehydrogenase (GLDH) into the perfusate was strongly correlated with their carbon chain length.	1-Butanol	84-93	glutamic--pyruvic transaminase	Rattus norvegicus	166-169
9973503-8	1999	Phagocytosis of EIgG was reduced by two inhibitors of PLD-mediated signaling, 2,3-diphosphoglycerate or 1-butanol.	1-Butanol	104-113	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	54-57
15825381-2	1998	If butyl alcohol (BuOH) is presented as a fourth component at the same time, RTP intensity of the system is enhanced obviously.	1-Butanol	3-16	MORN repeat containing 4	Homo sapiens	77-80
15825381-2	1998	If butyl alcohol (BuOH) is presented as a fourth component at the same time, RTP intensity of the system is enhanced obviously.	1-Butanol	18-22	MORN repeat containing 4	Homo sapiens	77-80
15825381-7	1998	As far as we can see that the system studied is a typical supramolecular assembly one and the BuOH acts as a molecular regulation for RTP emitting.	1-Butanol	94-98	MORN repeat containing 4	Homo sapiens	134-137
7656188-3	1995	Methanol, ethanol, n-propanol and n-butanol all induced higher ADH activity in wild-type larvae.	1-Butanol	34-43	Alcohol dehydrogenase	Drosophila melanogaster	63-66
9474757-1	1997	Enthalpy changes on the immersion of human serum albumin (HSA) into n-butanol, n-propanol, ethanol and methanol containing different amounts of water have been measured calorimetrically at 25 degrees C. Water sorption isotherms on HSA were also determined in water-n-butanol and water-ethanol mixtures.	1-Butanol	68-77	albumin	Homo sapiens	43-56
9474757-1	1997	Enthalpy changes on the immersion of human serum albumin (HSA) into n-butanol, n-propanol, ethanol and methanol containing different amounts of water have been measured calorimetrically at 25 degrees C. Water sorption isotherms on HSA were also determined in water-n-butanol and water-ethanol mixtures.	1-Butanol	265-274	albumin	Homo sapiens	43-56
9150275-3	1997	We first studied the effects of n-butanol, a phospholipase D (PLD) and protein kinase C (PKC) inhibitor, on the production of uPA in murine mammary adenocarcinoma cells.	1-Butanol	32-41	plasminogen activator, urokinase	Mus musculus	126-129
9150275-4	1997	Tumor cell monolayers treated during 24 h with 0.3% v/v n-butanol, secreted 45-50% less uPA to the culture medium than control monolayers (P < 0.001) as determined by radial caseinolysis, zymography and western blot.	1-Butanol	56-65	plasminogen activator, urokinase	Mus musculus	88-91
9150275-7	1997	Interestingly, a mild inhibition of uPA production was observed when PMA stimulation was assayed in cotreatments with n-butanol.	1-Butanol	118-127	plasminogen activator, urokinase	Mus musculus	36-39
9615614-3	1997	For n-butanol extracts containing oil red, 5"-nucleotidase, or alkaline phosphatase, the hydrophobic molecules and Triton X-114 were retained in the aqueous phase during incubations at 30 degrees C. The n-butanol interference was concentration-dependent and was reduced by lowering the final n-butanol concentration of the sample to 1.5% (v/v) or less.	1-Butanol	4-13	5'-nucleotidase ecto	Homo sapiens	43-58
9615614-3	1997	For n-butanol extracts containing oil red, 5"-nucleotidase, or alkaline phosphatase, the hydrophobic molecules and Triton X-114 were retained in the aqueous phase during incubations at 30 degrees C. The n-butanol interference was concentration-dependent and was reduced by lowering the final n-butanol concentration of the sample to 1.5% (v/v) or less.	1-Butanol	203-212	5'-nucleotidase ecto	Homo sapiens	43-58
9615614-3	1997	For n-butanol extracts containing oil red, 5"-nucleotidase, or alkaline phosphatase, the hydrophobic molecules and Triton X-114 were retained in the aqueous phase during incubations at 30 degrees C. The n-butanol interference was concentration-dependent and was reduced by lowering the final n-butanol concentration of the sample to 1.5% (v/v) or less.	1-Butanol	203-212	5'-nucleotidase ecto	Homo sapiens	43-58
9615614-4	1997	The results demonstrate how buffer-diluted n-butanol extracts of 5"-nucleotidase and alkaline phosphatase can be successfully employed for subsequent Triton X-114 fractionation of the enzymes.	1-Butanol	43-52	5'-nucleotidase ecto	Homo sapiens	65-80
9490511-4	1997	According to features of the inotropic action the studied agents were divided into two groups: Cth values of the former group were dependent on stimulation frequency (V, methanol, ethanol, isopropanol, chloral hydrate and acetone); Cth values of agents of the latter group were independent on stimulation frequency (n-butanol, n-pentanol, n-hexanol, and chloroform).	1-Butanol	316-325	V-set and immunoglobulin domain containing 2	Homo sapiens	95-98
9579573-8	1998	The alcohol n-butanol, a phospholipase D and protein kinase C inhibitor, besides inhibiting constitutive uPA secretion, blocked staurosporine-induced secretion.	1-Butanol	12-21	plasminogen activator, urokinase	Mus musculus	105-108
9245781-6	1997	The release of nascent secretory vesicles from the TGN was sensitive to 1% 1-butanol, a concentration that inhibited PLD-catalyzed formation of phosphatidic acid.	1-Butanol	75-84	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	117-120
21544328-4	1996	In the present study a short, 5-minute exposure of M3 cells to n-butanol (2.5% v/v) resulted in the complete inhibition of a secreted metalloproteinase activity of 105 kDa and a significant decrease in secreted urokinase (uPA) activity levels (p<0.01) measured in conditioned media after 72 hours of culture.	1-Butanol	63-72	proline-rich acidic protein 1	Mus musculus	222-225
21544328-6	1996	In contrast, cell-associated uPA activity of n-butanol pretreated M3 cells was mainly composed of a cytoplasmic uPA fraction and an extremely low membrane-bound uPA fraction (<5%).	1-Butanol	45-54	proline-rich acidic protein 1	Mus musculus	29-32
21544328-6	1996	In contrast, cell-associated uPA activity of n-butanol pretreated M3 cells was mainly composed of a cytoplasmic uPA fraction and an extremely low membrane-bound uPA fraction (<5%).	1-Butanol	45-54	proline-rich acidic protein 1	Mus musculus	112-115
21544328-6	1996	In contrast, cell-associated uPA activity of n-butanol pretreated M3 cells was mainly composed of a cytoplasmic uPA fraction and an extremely low membrane-bound uPA fraction (<5%).	1-Butanol	45-54	proline-rich acidic protein 1	Mus musculus	112-115
8615855-3	1995	The 11-OH-LA activity was strongly correlated with the CYP2E1 content, quantitated by immunoblot (r = 0.75) and with four monooxygenase activities known to be mediated by CYP2E1: chlorzoxazone-6-hydroxylation (r = 0.73), 4-nitrophenol hydroxylation (r = 0.84), N-nitrosodimethylamine demethylation (r = 0.79) and n-butanol oxidation (r = 0.73).	1-Butanol	313-322	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	55-61
8615855-3	1995	The 11-OH-LA activity was strongly correlated with the CYP2E1 content, quantitated by immunoblot (r = 0.75) and with four monooxygenase activities known to be mediated by CYP2E1: chlorzoxazone-6-hydroxylation (r = 0.73), 4-nitrophenol hydroxylation (r = 0.84), N-nitrosodimethylamine demethylation (r = 0.79) and n-butanol oxidation (r = 0.73).	1-Butanol	313-322	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	171-177
8640350-5	1995	In the presence of 2% n-butanol, mastoparan (3-100 microM) induced phosphatidylbutanol (PBut) accumulation in a concentration- and time-dependent manner, suggesting that mastoparan activates phospholipase D (PLD).	1-Butanol	22-31	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	191-206
8130257-3	1994	SP-A was isolated from bovine or rat lung surfactant by extraction with 1-butanol and octyl beta-D-glucopyranoside.	1-Butanol	72-81	pulmonary surfactant-associated protein A	Bos taurus	0-4
7882615-5	1995	Laminin-induced production of MMP-2 is attenuated by 1-butanol, a competitive substrate of PLD that reduces PLD-catalyzed production of PA.	1-Butanol	53-62	matrix metallopeptidase 2	Homo sapiens	30-35
7882615-5	1995	Laminin-induced production of MMP-2 is attenuated by 1-butanol, a competitive substrate of PLD that reduces PLD-catalyzed production of PA.	1-Butanol	53-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	91-94
7882615-5	1995	Laminin-induced production of MMP-2 is attenuated by 1-butanol, a competitive substrate of PLD that reduces PLD-catalyzed production of PA.	1-Butanol	53-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	108-111
7744038-1	1995	Aminopeptidase P from kidney cortex was purified in high yield (recovery greater than or equal to 20%) by a series of column chromatographic steps after solubilization of the membrane-bound glycoprotein with n-butanol.	1-Butanol	208-217	X-prolyl aminopeptidase 2	Sus scrofa	0-16
2040089-2	1991	The effects of various treatments (wheat-germ lectin, neuraminidase, n-butanol, papain, Triton X-100 and precipitation of LDL and VLDL) on the electrophoretic pattern of 5"-nucleotidase and alkaline phosphatase were studied.	1-Butanol	69-78	5'-nucleotidase ecto	Homo sapiens	170-185
8361957-0	1993	Selective extraction of alkaline phosphatase and 5"-nucleotidase from milk fat globule membranes by a single phase n-butanol procedure.	1-Butanol	115-124	5'-nucleotidase	Bos taurus	49-64
8361957-2	1993	For 5"-nucleotidase, higher n-butanol concentrations lead to loss of activity, while lower concentrations were ineffective in extracting the enzyme.	1-Butanol	28-37	5'-nucleotidase	Bos taurus	4-19
8361957-3	1993	When extractions were performed at 0 degrees C, similar yields were obtained for alkaline phosphatase extraction with 8% (v/v) n-butanol, but 5"-nucleotidase extraction required 10% (v/v) n-butanol for similar yields.	1-Butanol	188-197	5'-nucleotidase	Bos taurus	142-157
8361957-4	1993	However, 5"-nucleotidase was less susceptible to denaturation during extraction at 0 degrees C. The Km values and substrate specificities for both alkaline phosphatase and 5"-nucleotidase were unchanged by extraction with 8% (v/v) n-butanol.	1-Butanol	231-240	5'-nucleotidase	Bos taurus	172-187
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	1-Butanol	131-140	hemoglobin subunit gamma 2	Homo sapiens	63-68
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	1-Butanol	131-140	hemoglobin subunit gamma 2	Homo sapiens	144-149
7708906-5	1994	For preparations irradiated under N2O, the radiation yield for MetHb formation was three-fold lower in the presence of ethanol and 1-butanol [G(MetHb) = 0.33] compared with preparations irradiated in the presence of t-butanol or without alcohol [G(MetHb) = 1.00].	1-Butanol	131-140	hemoglobin subunit gamma 2	Homo sapiens	144-149
8214432-3	1993	CYP2E1 contents were correlated with 1-butanol oxidation and 6-hydroxylation of chlorzoxazone (r = 0.75 for both, p < 0.001).	1-Butanol	37-46	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
2037586-7	1991	In the presence of ethanol or n-butanol, transphosphatidylation by PLD resulted in the formation of [3H]phosphatidylethanol or - butanol, respectively, at the cost of PA and DG formation.	1-Butanol	30-39	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-70
1648952-2	1991	A protein extraction procedure utilizing single-phase concentrations of 1-butanol recovered a complex composed of T-ag, p53, and other Mr 35,000-60,000 proteins from suspension cultures of the simian virus 40-transformed mouse cell line mKSA.	1-Butanol	72-81	transformation related protein 53, pseudogene	Mus musculus	120-123
2221288-5	1990	These results suggest that NDMA and especially 1-butanol are the most specific and useful probes of alcohol-inducible cytochrome P-450 in crude liver microsomes.	1-Butanol	47-56	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-134
34405986-3	2021	In pursuit of a one-step synthesis of Guerbet alcohols from simple linear alcohol precursors, we show that MOF-derived RuCo alloys achieve over a million turnovers in the Guerbet reaction of 1-propanol, 1-butanol, and 1-pentanol.	1-Butanol	203-212	lysine acetyltransferase 8	Homo sapiens	107-110
2183625-6	1990	N-butanol, a known membrane fluidizer, partially inhibited the effect of rhTNF alpha on membrane fluidity and chemotaxis and completely reversed its effects on adherence and the expression of the CD11b antigen.	1-Butanol	0-9	integrin subunit alpha M	Homo sapiens	196-201
34596317-3	2021	Remarkably, the electrocatalyst yields ethanol, acetone and n-butanol as major products with a total C 2-4 faradaic efficiency of about 49% at -0.8 V vs. reversible hydrogen electrode (RHE), which can be maintained for at least 3 months.	1-Butanol	60-69	complement C2	Homo sapiens	101-106
34630086-8	2021	Results: At 10 weeks after treatment, osteoporosis-like phenotype were significantly ameliorated in SSTZF n-butanol extract (SSTZF-NB) group mice, as indicated by increased trabecular bone area and ALP content, and decreased lipid droplet area and FABP4 content.	1-Butanol	106-115	alopecia, recessive	Mus musculus	198-201
34630086-8	2021	Results: At 10 weeks after treatment, osteoporosis-like phenotype were significantly ameliorated in SSTZF n-butanol extract (SSTZF-NB) group mice, as indicated by increased trabecular bone area and ALP content, and decreased lipid droplet area and FABP4 content.	1-Butanol	106-115	fatty acid binding protein 4, adipocyte	Mus musculus	248-253
34567584-2	2021	The combined expression of StSUT1, encoding a sucrose transporter from potato (Solanum tuberosum), and SUC2, encoding a sucrose invertase from Saccharomyces cerevisiae, remarkably enhanced n-butanol production.	1-Butanol	189-198	sucrose transport protein-like	Solanum tuberosum	27-33
2324212-6	1990	A non-linear relationship was obtained for all the solutes in isopropanol, tert.-butanol and 1-butanol, in the alcohol volume fraction studied.	1-Butanol	93-102	telomerase reverse transcriptase	Homo sapiens	75-79
34319854-6	2021	A significant inhibition of COD removal was observed in the presence of tertiary-butyl alcohol.	1-Butanol	81-94	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	28-31
34136157-6	2021	Furthermore, the NBT subfraction reversed the disorders in glucose and lipid metabolism in insulin-resistant HepG2 cells and significantly increased the mRNA expression of phosphoinositide 3-kinases (PI3K) and AKT in insulin-resistant HepG2 cells in a dose-dependent manner.	1-Butanol	17-20	insulin	Homo sapiens	91-98
34149894-7	2021	The water isolated site (WA) and ethyl acetate isolated site (EA) significantly reversed complete Freund"s adjuvant (CFA)-induced changes in the levels of NO, IL-6, TNF-alpha, IgG and IFN-gamma, while the n-butanol isolated site (NB) only reversed the changes in IL-6 and IgG contents.	1-Butanol	205-214	interleukin 6	Rattus norvegicus	263-267
34136157-6	2021	Furthermore, the NBT subfraction reversed the disorders in glucose and lipid metabolism in insulin-resistant HepG2 cells and significantly increased the mRNA expression of phosphoinositide 3-kinases (PI3K) and AKT in insulin-resistant HepG2 cells in a dose-dependent manner.	1-Butanol	17-20	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	172-198
34136157-6	2021	Furthermore, the NBT subfraction reversed the disorders in glucose and lipid metabolism in insulin-resistant HepG2 cells and significantly increased the mRNA expression of phosphoinositide 3-kinases (PI3K) and AKT in insulin-resistant HepG2 cells in a dose-dependent manner.	1-Butanol	17-20	AKT serine/threonine kinase 1	Homo sapiens	210-213
34136157-6	2021	Furthermore, the NBT subfraction reversed the disorders in glucose and lipid metabolism in insulin-resistant HepG2 cells and significantly increased the mRNA expression of phosphoinositide 3-kinases (PI3K) and AKT in insulin-resistant HepG2 cells in a dose-dependent manner.	1-Butanol	17-20	insulin	Homo sapiens	217-224
34136157-8	2021	Overall, this study suggests that the NBT subfraction of the ethanol extract rich in glucosinolates modulates insulin resistance via PI3K/AKT activation in insulin-resistant HepG2 cells and might exert potentially beneficial effects in improving or treating glucose and lipid metabolic disorders.	1-Butanol	38-41	insulin	Homo sapiens	110-117
34136157-8	2021	Overall, this study suggests that the NBT subfraction of the ethanol extract rich in glucosinolates modulates insulin resistance via PI3K/AKT activation in insulin-resistant HepG2 cells and might exert potentially beneficial effects in improving or treating glucose and lipid metabolic disorders.	1-Butanol	38-41	AKT serine/threonine kinase 1	Homo sapiens	138-141
34136157-8	2021	Overall, this study suggests that the NBT subfraction of the ethanol extract rich in glucosinolates modulates insulin resistance via PI3K/AKT activation in insulin-resistant HepG2 cells and might exert potentially beneficial effects in improving or treating glucose and lipid metabolic disorders.	1-Butanol	38-41	insulin	Homo sapiens	156-163
35531699-0	2022	(Butyl alcohol extract of Baitouweng Decoction alleviates vulvovaginal candidiasis in mice by downregulating NLRP3 inflammasome and related signal pathways).	1-Butanol	1-14	NLR family, pyrin domain containing 3	Mus musculus	109-114
35500255-6	2022	This experimental procedure and analysis is extended to bovine serum albumin, transferrin, immunoglobulin G, and apoferritin with water, 1-butanol, and nonane.	1-Butanol	137-146	ferritin heavy chain 1	Homo sapiens	113-124
35531699-1	2022	This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome.	1-Butanol	41-54	myeloid differentiation primary response gene 88	Mus musculus	194-199
35531699-1	2022	This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome.	1-Butanol	41-54	C-type lectin domain family 7, member a	Mus musculus	204-212
35531699-1	2022	This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome.	1-Butanol	41-54	spleen tyrosine kinase	Mus musculus	213-216
35531699-1	2022	This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome.	1-Butanol	41-54	NLR family, pyrin domain containing 3	Mus musculus	237-242
35393407-3	2022	Here, we engineer the actin cytoskeleton in S. cerevisiae to increase both the cell growth and production of n-butanol and medium-chain fatty acids.	1-Butanol	109-118	actin	Saccharomyces cerevisiae S288C	22-27
35393407-4	2022	Actin cable tortuosity is regulated using an n-butanol responsive promoter-based autonomous bidirectional signal conditioner in S. cerevisiae.	1-Butanol	45-54	actin	Saccharomyces cerevisiae S288C	0-5
34991410-7	2022	RESULTS: Ethyl acetate and n-butanol fractions of D. roxburghiana were strongly active against NFkappaB with IC50 of 16.6 +- 1.3 and 8.4 +- 0.7 microg/ml respectively with 100% survival.	1-Butanol	27-36	nuclear factor kappa B subunit 1	Homo sapiens	95-103
3392021-1	1988	Membrane and soluble forms of alkaline phosphatase (ALP) were selectively prepared from human placental microsomes by treatment with 1-butanol at pH 8.5 and 5.5, respectively.	1-Butanol	133-142	alkaline phosphatase, placental	Homo sapiens	30-50
3392021-1	1988	Membrane and soluble forms of alkaline phosphatase (ALP) were selectively prepared from human placental microsomes by treatment with 1-butanol at pH 8.5 and 5.5, respectively.	1-Butanol	133-142	alkaline phosphatase, placental	Homo sapiens	52-55
3936839-1	1985	Subtilosin A, a new antibiotic produced by Bacillus subtilis 168, was extracted from culture medium with n-butanol and purified to homogeneity by a combination of gel filtration and thin-layer chromatography.	1-Butanol	105-114	subtilosin A	Bacillus subtilis subsp. subtilis str. 168	0-12
3355173-2	1988	Lysosomal glucocerebrosidase was extracted with sodium cholate and 1-butanol to render its beta-glucosidase activity dependent upon exogenous lipids.	1-Butanol	67-76	glucosylceramidase beta	Homo sapiens	0-28
2446803-6	1987	In cord sera, delipidation with n-butanol brought about loss of GGT activity and a shift from an alpha 1 to an alpha 2 position, whereas no significant effect of this kind was observed in adult sera.	1-Butanol	32-41	adrenoceptor alpha 1D	Homo sapiens	97-104
3257414-7	1988	Thus RTT-2, which displays specific tumoricidal activity in vitro and in vivo, may afford a suitable tool to dissect T-cell receptors recognizing tumor markers on 1-butanol-extracted, MCA-F TSTA.	1-Butanol	163-172	heat shock protein 90 alpha (cytosolic), class B member 1	Mus musculus	190-194
2944861-6	1986	The rats rejected the T-9 cells, whereas the FTL-13 cells grew gradually until the host died, indicating that the n-butanol extract from T-9 cells contained T-9 cell-specific TATA.	1-Butanol	114-123	ferritin light chain 1	Rattus norvegicus	45-48
3085988-1	1986	Sequential extraction of human spleen membranes with sodium cholate and n-butanol removes endogenous lipids and renders glucocerebrosidase activity dependent upon exogenous acidic lipids (e.g., phosphatidylserine, gangliosides) and a heat-stable activator protein (HSF).	1-Butanol	72-81	interleukin 6	Homo sapiens	265-268
4093520-1	1985	Free carboxyl groups of bovine beta-lactoglobulin were esterified with methanol, ethanol, and n-butanol.	1-Butanol	94-103	beta-lactoglobulin	Bos taurus	31-49
4093520-13	1985	Use of the hydroxamic acid reaction made it possible to estimate the apparent extent of carboxyl modification of beta-lactoglobulin through esterification with methanol, ethanol, and n-butanol.	1-Butanol	183-192	beta-lactoglobulin	Bos taurus	113-131
2408745-0	1985	Biochemical characterization of 1-butanol-extracted murine tumor-specific transplantation antigens.	1-Butanol	32-41	heat shock protein 90, alpha (cytosolic), class A member 1	Mus musculus	59-98
2408745-4	1985	Brief incubation of intact tumor cells in single-phase aqueous solutions of 2.5% (v/v) 1-butanol extracts an immunoprotective TSTA, but not alloantigenic activity, from MCA-F cells.	1-Butanol	87-96	heat shock protein 90, alpha (cytosolic), class A member 1	Mus musculus	126-130
6296101-4	1983	The production of ethylene from 4-ketothiomethylbutyrate or of formaldehyde from either dimethyl sulfoxide or tertiary butyl alcohol was measured in the presence of NADPH plus reductase or NADPH plus reductase plus cytochrome P-450.	1-Butanol	119-132	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	215-231
3924124-2	1985	Using n-butanol, a solubilized preparation of neuraminidase with specific activity considerably exceeding the initial activity of the chorion homogenate was obtained.	1-Butanol	6-15	neuraminidase 1	Homo sapiens	46-59
4015835-2	1985	The reconstituted alcohol-P-450 oxygenase (APO) system containing P-450ALC and NADPH-cytochrome P-450 reductase catalyzes the oxidation of a variety of primary and secondary alcohols to aldehydes and ketones, including methanol, ethanol, n-propanol, n-butanol, 2-butanol, n-pentanol, and cyclohexanol.	1-Butanol	250-259	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	79-111
6334084-1	1984	Human renal dipeptidase has been concentrated from kidneys by homogenization, 1-butanol solubilization, and (NH4)2SO4 fractionation.	1-Butanol	78-87	dipeptidase 1	Homo sapiens	6-23
6514184-9	1984	Similar changes in Ca2+ ion activity were produced by tertiary-butyl alcohol, but the magnitude of its effect was generally less than that of ethanol, suggesting that its effect on brain tissue differs from that of ethanol.	1-Butanol	63-76	carbonic anhydrase 2	Rattus norvegicus	19-22
6422854-1	1984	Lysosomal glucocerebrosidase of human tissues is reversibly inactivated by extraction with sodium cholate and n-butanol.	1-Butanol	110-119	glucosylceramidase beta	Homo sapiens	0-28
7187061-1	1982	The effect of 1-propanol, 2-propanol, n-butanol, ethanol and methanol an sorbitol dehydrogenase activity was assayed.	1-Butanol	38-47	sorbitol dehydrogenase	Homo sapiens	73-95
598170-3	1977	PPi ase was largely destroyed during extraction with n-butanol, which facilitated the solubilization of alkaline phosphatase and ATP splitting enzymes and only partially destroyed acid phosphatase.	1-Butanol	53-62	peptidylprolyl isomerase F	Rattus norvegicus	0-7
6185990-4	1981	A phase partition method with aqueous preparations of rat alpha 1 fetoprotein allowed extraction of this chromophore into n-butanol and determination of its spectrofluorimetric characteristics: an excitation maximum at 305 nm and an emission maximum at 365 nm.	1-Butanol	122-131	alpha-fetoprotein	Rattus norvegicus	58-77
521256-1	1979	A purification procedure of uricase from ox kidneys has been worked out starting from a n-butanol extract.	1-Butanol	88-97	urate oxidase (pseudogene)	Homo sapiens	28-35
472708-1	1979	By using the chelate EDTA at low concentration to remove the bivalent cations in the plasma membranes and followed by n-butanol to extract the membrane lipids, we have obtained a water-soluble insulin receptor without detergent from the liver-cell plasma membranes.	1-Butanol	118-127	insulin receptor	Homo sapiens	193-209
12170593-1	1976	Dopamine-beta-hydroxylase (DBH) was purified from rat adrenal medulla by a series of steps including sedimentation of membranes, extraction with n-butanol, ammonium sulfate fractionation, gel chromatography and ion-exchange chromatography.	1-Butanol	145-154	dopamine beta-hydroxylase	Rattus norvegicus	0-25
144724-2	1977	With increasing alcohol concentration, the ATPase activity reached a maximum (in the case of n-butanol, at about 350 mM) and then decreased.	1-Butanol	93-102	dynein axonemal heavy chain 8	Homo sapiens	43-49
144724-4	1977	The purified ATPase enzyme and leaky vesicles treated with Triton X-100 or phospholipase A showed high ATPase activity in the absence of n-butanol.	1-Butanol	137-146	dynein axonemal heavy chain 8	Homo sapiens	13-19
144724-4	1977	The purified ATPase enzyme and leaky vesicles treated with Triton X-100 or phospholipase A showed high ATPase activity in the absence of n-butanol.	1-Butanol	137-146	phospholipase A and acyltransferase 1	Homo sapiens	59-90
144724-5	1977	With increasing n-butanol concentration, their atpase activities began to decrease above about 250 mM n-butanol, without any enhancement.	1-Butanol	16-25	dynein axonemal heavy chain 8	Homo sapiens	47-53
144724-5	1977	With increasing n-butanol concentration, their atpase activities began to decrease above about 250 mM n-butanol, without any enhancement.	1-Butanol	102-111	dynein axonemal heavy chain 8	Homo sapiens	47-53
12170593-1	1976	Dopamine-beta-hydroxylase (DBH) was purified from rat adrenal medulla by a series of steps including sedimentation of membranes, extraction with n-butanol, ammonium sulfate fractionation, gel chromatography and ion-exchange chromatography.	1-Butanol	145-154	dopamine beta-hydroxylase	Rattus norvegicus	27-30
1168529-1	1975	In Micrococcus sodonensis and some other Micrococcus species, adenosien deaminase is present both as a membran-bound and a soluble enzyme; The membran-bound adenosine deaminase can be extracted with n-butanol, and may account for up to 5% of the total cellular adenosine deaminase activity.	1-Butanol	199-208	adenosine deaminase	Bos taurus	157-176
33215267-7	2020	The n-butanol fraction was the most effective in inhibiting eGST, hGSTP1-1, and pGST with IC50 values of 3.0 +- 0.7, 4.85 +- 0.35, and 6.6 +- 1.2 mug/ml, respectively.	1-Butanol	4-13	glutathione S-transferase pi 1	Homo sapiens	66-74
5862439-0	1965	Utilization of 1-butanol for the preparation of pancreatic lipase.	1-Butanol	15-24	pancreatic lipase	Homo sapiens	48-65
33838173-3	2021	Data on read-across materials butyl alcohol (CAS # 71-36-3) and lactic acid (CAS # 50-21-5) provide a calculated margin of exposure (MOE) >100 for the repeated dose and reproductive toxicity endpoints.	1-Butanol	30-43	BCAR1 scaffold protein, Cas family member	Homo sapiens	45-48
33329003-0	2020	N-Butanol Fraction of Wenxia Formula Extract Inhibits the Growth and Invasion of Non-Small Cell Lung Cancer by Down-Regulating Sp1-Mediated MMP2 Expression.	1-Butanol	0-9	matrix metallopeptidase 2	Homo sapiens	140-144
14043987-8	1963	"Insensitive" cells could be sensitized by the addition of potassium hydroxide, n-butanol, steapsin, or urea, as demonstrated by the subsequent addition of lysozyme.	1-Butanol	80-89	lysozyme	Homo sapiens	156-164
33214880-0	2020	Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC.	1-Butanol	59-68	kelch like ECH associated protein 1	Homo sapiens	18-23
33294662-5	2020	Although gasderminD (GSDMD) cleavage by caspase-1 was not observed, GSDME cleavage by caspase-3 was observed during exposure to 150 mM 1-butanol for 6 h. We conclude that pyroptotic cell death by 1-butanol in H9c2 cardiomyoblastoma cells should occur via the caspase-3-GSDME pathway, revealing that 1-butanol could induce not only apoptosis but also pyroptosis in the cells.	1-Butanol	135-144	gasdermin E	Rattus norvegicus	68-73
33294662-5	2020	Although gasderminD (GSDMD) cleavage by caspase-1 was not observed, GSDME cleavage by caspase-3 was observed during exposure to 150 mM 1-butanol for 6 h. We conclude that pyroptotic cell death by 1-butanol in H9c2 cardiomyoblastoma cells should occur via the caspase-3-GSDME pathway, revealing that 1-butanol could induce not only apoptosis but also pyroptosis in the cells.	1-Butanol	135-144	caspase 3	Rattus norvegicus	86-95
33294662-5	2020	Although gasderminD (GSDMD) cleavage by caspase-1 was not observed, GSDME cleavage by caspase-3 was observed during exposure to 150 mM 1-butanol for 6 h. We conclude that pyroptotic cell death by 1-butanol in H9c2 cardiomyoblastoma cells should occur via the caspase-3-GSDME pathway, revealing that 1-butanol could induce not only apoptosis but also pyroptosis in the cells.	1-Butanol	135-144	caspase 3	Rattus norvegicus	259-268
33294662-5	2020	Although gasderminD (GSDMD) cleavage by caspase-1 was not observed, GSDME cleavage by caspase-3 was observed during exposure to 150 mM 1-butanol for 6 h. We conclude that pyroptotic cell death by 1-butanol in H9c2 cardiomyoblastoma cells should occur via the caspase-3-GSDME pathway, revealing that 1-butanol could induce not only apoptosis but also pyroptosis in the cells.	1-Butanol	135-144	gasdermin E	Rattus norvegicus	269-274
33214880-0	2020	Activation of the Keap1-Nrf2 pathway by specioside and the n-butanol extract from the inner bark of Tabebuia rosea (Bertol) DC.	1-Butanol	59-68	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
33214880-2	2020	The aim of this study was to evaluate the activation of the Keap1-Nrf2 pathway by both the n-butanol extract obtained from the inner bark of Tabebuia rosea (Bertol) DC and specioside isolated from this extract.	1-Butanol	91-100	kelch like ECH associated protein 1	Homo sapiens	60-65
33214880-2	2020	The aim of this study was to evaluate the activation of the Keap1-Nrf2 pathway by both the n-butanol extract obtained from the inner bark of Tabebuia rosea (Bertol) DC and specioside isolated from this extract.	1-Butanol	91-100	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
33214880-8	2020	In addition, Nrf2 dissociated from Keap1 after treatment with the n-butanol extract at a concentration of 0.25 microg/mL after 4 hours of exposure.	1-Butanol	66-75	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
33214880-8	2020	In addition, Nrf2 dissociated from Keap1 after treatment with the n-butanol extract at a concentration of 0.25 microg/mL after 4 hours of exposure.	1-Butanol	66-75	kelch like ECH associated protein 1	Homo sapiens	35-40
32687705-5	2020	In this study we report the gas-phase association energies, enthalpies, and entropies for protonated phenylalanine ion clustered with three neutral vapor molecules: 2-propanol, 1-butanol, and 2-pentanol based upon measurements at temperatures ranging from 120 oC to 180 oC.	1-Butanol	177-186	gastrin	Homo sapiens	28-31
31741085-1	2020	The reactive distillation process for the synthesis of n-butyl acetate via transesterification of ethyl acetate with n-butyl alcohol catalyzed by immobilized lipase was simulated and experimentally tested in this work.	1-Butanol	117-132	PAN0_003d1715	Moesziomyces antarcticus	158-164
32721259-1	2020	Ethanol extract (RET) of Rosa multiflora Thunb flowers and its subfractions in ethylacetate (REA) or n-butanol subfractions (RBT) were reported to have potent antioxidative and anti-inflammatory activities.	1-Butanol	101-110	ret proto-oncogene	Mus musculus	17-20
32549262-11	2020	We found that 1-butanol and 1-pentanol increased in both TNF-alpha groups after 20 h compared to the control.	1-Butanol	14-23	tumor necrosis factor	Rattus norvegicus	57-66
31741085-6	2020	Compared to the batch reaction with only 60% conversion of n-butanol, the reactive distillation column can improve the conversion of n-butanol (up to 93.6%).At the same time, the experiment verified that the conversion of n-butanol could still reach 72.5%, after the lipase-loaded packing storage in the reaction system at 70  C for 120 days.	1-Butanol	59-68	PAN0_003d1715	Moesziomyces antarcticus	267-273
31741085-6	2020	Compared to the batch reaction with only 60% conversion of n-butanol, the reactive distillation column can improve the conversion of n-butanol (up to 93.6%).At the same time, the experiment verified that the conversion of n-butanol could still reach 72.5%, after the lipase-loaded packing storage in the reaction system at 70  C for 120 days.	1-Butanol	133-142	PAN0_003d1715	Moesziomyces antarcticus	267-273
31741085-6	2020	Compared to the batch reaction with only 60% conversion of n-butanol, the reactive distillation column can improve the conversion of n-butanol (up to 93.6%).At the same time, the experiment verified that the conversion of n-butanol could still reach 72.5%, after the lipase-loaded packing storage in the reaction system at 70  C for 120 days.	1-Butanol	133-142	PAN0_003d1715	Moesziomyces antarcticus	267-273
31563324-9	2019	Here we found that the attenuation of PA production with 1-butanol or a PLD inhibitor prevented the 1,25(OH)2D3-induced upregulation of CD14.	1-Butanol	57-66	CD14 molecule	Homo sapiens	136-140
32116723-8	2020	As the n-butanol and ethyl acetate extracts were found to have potent anti-inflammatory and alpha-glucosidase-inhibitory activities, we separated and identified 10 compounds from the extracts.	1-Butanol	7-16	sucrase isomaltase (alpha-glucosidase)	Mus musculus	92-109
32143602-6	2020	RESULTS: The n-butanol part of ethanol extract from RS showed a strong alpha-glucosidase inhibition activity (90.55%, IC50 0.551 mg/mL) against positive control acarbose (90.59%, IC50 1.079 mg/mL).	1-Butanol	13-22	sucrase-isomaltase	Homo sapiens	71-88
31874099-3	2019	Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE).	1-Butanol	97-106	sucrase-isomaltase	Homo sapiens	160-177
31874099-3	2019	Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE).	1-Butanol	97-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	179-199
31874099-3	2019	Background This study evaluates the antioxidant activity and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa leaves on alpha-amylase, alpha-glucosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, arginase, phosphodiesterase 5 (PDE-5), and angiotensin converting enzyme (ACE).	1-Butanol	97-106	acetylcholinesterase (Cartwright blood group)	Homo sapiens	201-205
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	sucrase-isomaltase	Homo sapiens	61-78
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	butyrylcholinesterase	Homo sapiens	101-105
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	tyrosinase	Homo sapiens	107-117
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	phosphodiesterase 5A	Homo sapiens	129-134
31874099-7	2019	The n-butanol fraction of S. podocarpa leaves also inhibited alpha-glucosidase, alpha-amylase, AChE, BChE, tyrosinase, arginase, PDE-5, and ACE at the concentration tested.	1-Butanol	4-13	angiotensin I converting enzyme	Homo sapiens	140-143
31833703-10	2019	The obtained crude n-butanol extract was diluted to 1 mug mL-1, which still had inhibitory effect for Escherichia coli.	1-Butanol	19-28	L1 cell adhesion molecule	Mus musculus	58-62
31638777-1	2019	RuNi nanoparticles supported on a metal-organic framework (RuNi@MOF) and formed in situ from a ruthenium complex enclosed inside a nickel-based MOF act as a highly active catalyst for the Guerbet reaction of ethanol to 1-butanol, providing turnover numbers up to 725 000 Ru-1.	1-Butanol	219-228	lysine acetyltransferase 8	Homo sapiens	64-67
31638777-1	2019	RuNi nanoparticles supported on a metal-organic framework (RuNi@MOF) and formed in situ from a ruthenium complex enclosed inside a nickel-based MOF act as a highly active catalyst for the Guerbet reaction of ethanol to 1-butanol, providing turnover numbers up to 725 000 Ru-1.	1-Butanol	219-228	lysine acetyltransferase 8	Homo sapiens	144-147
31638777-2	2019	Negligible activity of the RuNi@MOF ethanol upgrading catalyst system toward chemically similar 1-butanol makes it possible to synthesize the competent Guerbet substrate 1-butanol with >99% selectivity.	1-Butanol	96-105	lysine acetyltransferase 8	Homo sapiens	32-35
31638777-2	2019	Negligible activity of the RuNi@MOF ethanol upgrading catalyst system toward chemically similar 1-butanol makes it possible to synthesize the competent Guerbet substrate 1-butanol with >99% selectivity.	1-Butanol	170-179	lysine acetyltransferase 8	Homo sapiens	32-35
31269239-8	2019	Importantly, we found that phospholipase D inhibitor, n-butanol, phospholipase D siRNA, and wortmannin significantly decreased OGD/R-induced and ATP-enhanced release of NAMPT in microglia.	1-Butanol	54-63	nicotinamide phosphoribosyltransferase	Homo sapiens	169-174
31653887-6	2019	Our calculations show that energy barriers for n-butanol oxidation increase in the order of alpha < O < Upsilon < beta < xi, which are consistent with previous data.	1-Butanol	47-56	lymphotoxin beta	Homo sapiens	119-127
30740576-0	2018	Phospholipase D antagonist 1-butanol inhibited the mobilization of triacylglycerol during seed germination in Arabidopsis.	1-Butanol	27-36	phospholipase D alpha 1	Arabidopsis thaliana	0-15
30940361-0	2019	Possible involvement of alpha B-crystallin in the cardioprotective effect of n-butanol extract of Potentilla anserina L. on myocardial ischemia/reperfusion injury in rat.	1-Butanol	77-86	crystallin, alpha B	Rattus norvegicus	24-42
30811931-6	2019	Here we used US to study the guest aspirin and 1-butanol dissociation processes of beta-cyclodextrin (beta-CD) and an inhibitor SB2 dissociation from a p38alpha mitogen-activated protein kinase (MAPK) complex.	1-Butanol	47-56	mitogen-activated protein kinase 14	Homo sapiens	152-160
30620599-4	2019	However, the kinetic parameters of the reactions are basically extrapolated by analogy to the n-butanol + HO2 system calculated by Zhou et al.	1-Butanol	94-103	heme oxygenase 2	Homo sapiens	106-109
30620599-15	2019	Similar to the n-butanol + HO2 system, the title system is dominated by alpha-site H-atom abstraction, but the rate coefficients of the three channels are slightly slower than that of the n-butanol + HO2 system.	1-Butanol	15-24	heme oxygenase 2	Homo sapiens	27-30
30620599-15	2019	Similar to the n-butanol + HO2 system, the title system is dominated by alpha-site H-atom abstraction, but the rate coefficients of the three channels are slightly slower than that of the n-butanol + HO2 system.	1-Butanol	15-24	heme oxygenase 2	Homo sapiens	200-203
30620599-15	2019	Similar to the n-butanol + HO2 system, the title system is dominated by alpha-site H-atom abstraction, but the rate coefficients of the three channels are slightly slower than that of the n-butanol + HO2 system.	1-Butanol	188-197	heme oxygenase 2	Homo sapiens	27-30
30620599-15	2019	Similar to the n-butanol + HO2 system, the title system is dominated by alpha-site H-atom abstraction, but the rate coefficients of the three channels are slightly slower than that of the n-butanol + HO2 system.	1-Butanol	188-197	heme oxygenase 2	Homo sapiens	200-203
30679589-7	2019	Moreover, Huaier n-butanol extract suppressed the c-Myc-Bmi1 signalling pathway, and overexpression of Bmi1 reversed the effects of Huaier n-butanol extract on GC cells.	1-Butanol	17-26	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-55
30679589-7	2019	Moreover, Huaier n-butanol extract suppressed the c-Myc-Bmi1 signalling pathway, and overexpression of Bmi1 reversed the effects of Huaier n-butanol extract on GC cells.	1-Butanol	17-26	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	56-60
30679589-8	2019	Thus, our findings indicate that Huaier n-butanol extract suppresses the proliferation and metastasis of GC cells via a c-Myc-Bmi1-mediated approach, providing a new perspective for our understanding of the anti-tumour effects of Huaier.	1-Butanol	40-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	120-125
30679589-8	2019	Thus, our findings indicate that Huaier n-butanol extract suppresses the proliferation and metastasis of GC cells via a c-Myc-Bmi1-mediated approach, providing a new perspective for our understanding of the anti-tumour effects of Huaier.	1-Butanol	40-49	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	126-130
30740576-2	2018	1-Butanol, a specific inhibitor of phospholipase D (PLD)-dependent production of the signalling molecule phosphatidic acid (PA), inhibited Arabidopsis seed germination.	1-Butanol	0-9	phospholipase D alpha 1	Arabidopsis thaliana	35-50
30740576-2	2018	1-Butanol, a specific inhibitor of phospholipase D (PLD)-dependent production of the signalling molecule phosphatidic acid (PA), inhibited Arabidopsis seed germination.	1-Butanol	0-9	phospholipase D alpha 1	Arabidopsis thaliana	52-55
29984178-5	2018	n-Butanol fraction of Zanthoxylum alatum showed maximum PTP-1B inhibition (61.9%) whereas ethanol extract of Tanacetum nubigenum showed strong stimulation of glucose uptake (+61.2%) in C2Cl2 myotubes.	1-Butanol	0-9	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	56-62
30356884-5	2018	With this experiment, we aimed to explore the influence of intranasal insulin on olfactory sensitivity for the odors n-butanol and peanut in a placebo-controlled, double-blind setting in a within-subject design.	1-Butanol	117-126	insulin	Homo sapiens	70-77
30356884-12	2018	Our results indicate that the effects of cortical insulin levels on processing of specific odors is likely modulated by gender, as central increase of insulin concentration led to a reduced olfactory sensitivity for n-butanol in women only, which might be due to differentially regulated insulin and leptin signaling in men and women.	1-Butanol	216-225	insulin	Homo sapiens	50-57
30356884-12	2018	Our results indicate that the effects of cortical insulin levels on processing of specific odors is likely modulated by gender, as central increase of insulin concentration led to a reduced olfactory sensitivity for n-butanol in women only, which might be due to differentially regulated insulin and leptin signaling in men and women.	1-Butanol	216-225	insulin	Homo sapiens	151-158
30356884-12	2018	Our results indicate that the effects of cortical insulin levels on processing of specific odors is likely modulated by gender, as central increase of insulin concentration led to a reduced olfactory sensitivity for n-butanol in women only, which might be due to differentially regulated insulin and leptin signaling in men and women.	1-Butanol	216-225	insulin	Homo sapiens	151-158
28587487-9	2018	Dianosides M-N increased IL-1beta concentration significantly whereas the n-butanol fraction slightly augmented IL-1beta secretion.	1-Butanol	74-83	interleukin 1 beta	Homo sapiens	112-120
30198579-3	2018	After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding.	1-Butanol	69-78	phospholipase D gamma 1	Gossypium hirsutum	100-103
30198579-3	2018	After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding.	1-Butanol	69-78	ferric reduction oxidase 4	Gossypium hirsutum	132-139
30198579-3	2018	After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding.	1-Butanol	174-183	phospholipase D gamma 1	Gossypium hirsutum	100-103
30198579-3	2018	After developing a novel fluorimetric assay for the investigation of n-butanol inhibitory effect on PLD activity, we show that only NADPHox gene upregulation is reduced when n-butanol is applied prior to wounding.	1-Butanol	174-183	ferric reduction oxidase 4	Gossypium hirsutum	132-139
29577626-3	2018	The solubility of PBIPO in n-butyl alcohol was more than 20 mg mL-1 , which meets the requirement for fully solution-processed organic light-emitting diodes (OLEDs).	1-Butanol	27-42	L1 cell adhesion molecule	Mus musculus	63-67
27367189-4	2017	RESULTS: Wortmannin and 1-butanol induced a decrease in protein kinase B (phospho-Akt) and the rate of PS (P < 0.05) versus Control.	1-Butanol	24-33	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
29155060-11	2018	We discover that phosphate from PEP utilization, along with other physiochemical reagents, during cell-free protein synthesis-coupled, crude-lysate metabolic system operation inhibits optimal cell-free n-butanol metabolism.	1-Butanol	202-211	progestagen associated endometrial protein	Homo sapiens	32-35
29115434-7	2018	The addition of n-butanol extract from Folium isatidis inhibited this LPS-induced downregulation of CXCR1, CXCR2 and CD62L, and decreased the expression of IL-8 on neutrophils.	1-Butanol	16-25	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
29115434-8	2018	In addition, n-butanol extract promoted myeloperoxidase activity in neutrophils.	1-Butanol	13-22	myeloperoxidase	Homo sapiens	40-55
28884086-10	2017	Finally, among four different fractions of OHS extract, n-butanol fraction strongly decreased NO production (p<0.0001) and iNOS expression in LPS-induced RAW 264.7 cells.	1-Butanol	56-65	nitric oxide synthase 2, inducible	Mus musculus	126-130
28533957-8	2017	However, spindle migration could not be totally prevented by PLD2 catalytic specific inhibitors, FIPI and 1-butanol, implying at least partially, that PLD2 effect on spindle migration needs non-catalytic domain participation.	1-Butanol	106-115	phospholipase D2	Mus musculus	151-155
28490713-6	2017	However, inhibition of hydrolytic activity of PLD by 1-butanol treatment showed little or no effect on agonist-induced chemotaxis.	1-Butanol	53-62	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	46-49
29115434-0	2018	n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils.	1-Butanol	0-9	C-X-C motif chemokine receptor 1	Homo sapiens	97-102
29115434-0	2018	n-butanol extract from Folium isatidis inhibits the lipopolysaccharide-induced downregulation of CXCR1 and CXCR2 on human neutrophils.	1-Butanol	0-9	C-X-C motif chemokine receptor 2	Homo sapiens	107-112
29115434-7	2018	The addition of n-butanol extract from Folium isatidis inhibited this LPS-induced downregulation of CXCR1, CXCR2 and CD62L, and decreased the expression of IL-8 on neutrophils.	1-Butanol	16-25	C-X-C motif chemokine receptor 1	Homo sapiens	100-105
29115434-7	2018	The addition of n-butanol extract from Folium isatidis inhibited this LPS-induced downregulation of CXCR1, CXCR2 and CD62L, and decreased the expression of IL-8 on neutrophils.	1-Butanol	16-25	C-X-C motif chemokine receptor 2	Homo sapiens	107-112
29115434-7	2018	The addition of n-butanol extract from Folium isatidis inhibited this LPS-induced downregulation of CXCR1, CXCR2 and CD62L, and decreased the expression of IL-8 on neutrophils.	1-Butanol	16-25	selectin L	Homo sapiens	117-122
29027933-11	2017	What"s more, the inhibitory effect of ME of PLT and its EA and n-BuOH fractions on alpha-glucosidase was significantly higher than that of acarbose.	1-Butanol	65-69	sucrase isomaltase (alpha-glucosidase)	Mus musculus	83-100
28259164-3	2017	We have previously shown that n-butanol extracts of Morinda citrifolia (noni), a plant belonging to the family Rubiaceae, block the binding of AGEs to RAGE in vitro.	1-Butanol	30-39	long intergenic non-protein coding RNA 914	Homo sapiens	151-155
28259164-7	2017	RESULTS: N-butanol extracts of noni at 670 ng/ml significantly inhibited the AGE-induced ROS generation and RAGE, intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 gene expressions in HUVECs.	1-Butanol	9-18	long intergenic non-protein coding RNA 914	Homo sapiens	108-112
28259164-7	2017	RESULTS: N-butanol extracts of noni at 670 ng/ml significantly inhibited the AGE-induced ROS generation and RAGE, intercellular adhesion molecule-1 and plasminogen activator inhibitor-1 gene expressions in HUVECs.	1-Butanol	9-18	intercellular adhesion molecule 1	Homo sapiens	114-185
28259164-9	2017	CONCLUSIONS: The present study demonstrated for the first time that N-butanol extracts of noni could suppress the AGE-induced inflammatory reactions in HUVECs through its anti-oxidative properties via blocking of the interaction of AGEs with RAGE.	1-Butanol	68-77	long intergenic non-protein coding RNA 914	Homo sapiens	242-246
28259164-10	2017	Inhibition of the AGE-RAGE axis by n-butanol extracts of noni may be a novel nutraceutical strategy for the treatment of cardiovascular disease.	1-Butanol	35-44	long intergenic non-protein coding RNA 914	Homo sapiens	22-26
26334321-7	2016	A butyl alcohol stimulus increased immediate-early gene c-Fos expression in the olfactory system of WT mice, while this response was absent in GluN3A KO mice.	1-Butanol	2-15	jun proto-oncogene	Mus musculus	35-50
27334427-1	2016	In our previous work, organic solvents, especially 1-butanol, play a key role to separate highly hydrophobic analytes in EKC using the polymeric micelle self-assembled from amphiphilic random copolymer poly (stearyl methacrylate-co-methyl acrylic acid) (P(SMA-co-MAA)) as a novel pseudostationary phase.	1-Butanol	51-60	survival of motor neuron 1, telomeric	Homo sapiens	256-259
28401088-4	2017	In brief, RSL powder was fractionated into n-hexane, chloroform, ethyl acetate, n-butanol, and water-soluble fractions.	1-Butanol	80-89	regulator of sex limited protein-Slp	Mus musculus	10-13
28134352-4	2017	In this study, we used n-butyl alcohol extract of Litchi seed (NLS) to treat prostate cancer PC3, DU145, RM1 and C4-2B cells.	1-Butanol	23-38	proprotein convertase subtilisin/kexin type 1	Mus musculus	93-96
26334321-7	2016	A butyl alcohol stimulus increased immediate-early gene c-Fos expression in the olfactory system of WT mice, while this response was absent in GluN3A KO mice.	1-Butanol	2-15	FBJ osteosarcoma oncogene	Mus musculus	56-61
27267173-5	2016	Their membrane properties were assessed for butanol recovery by pervaporation from a model aqueous solution containing 2 wt % of n-butanol at 50  C. The membrane flux J50mum for a reference thickness of 50 mum strongly increased from 84 to 192 g/h m(2) with increasing PDMS content for free-standing dense membranes with thicknesses in the range of 38-95 mum.	1-Butanol	129-138	latexin	Homo sapiens	170-173
27050993-15	2016	In conclusion, the n-butyl alcohol phase of T. sinensis seed extract has protective effects on DN rats via the inhibition of oxidative stress and protein expression of TGF-b1, collagen IV, and CTGF.	1-Butanol	19-34	transforming growth factor, beta 1	Rattus norvegicus	168-174
26867555-7	2016	Eco-friendly mobile phase containing 0.12 M sodium dodecyl sulphate, 0.3% triethylamine and 6%n-butanol in 0.02 M orthophosphoric acid of pH 3.0 was pumped at a flow rate of 1 mL/min.	1-Butanol	94-103	ciliogenesis associated kinase 1	Homo sapiens	0-3
27161023-6	2016	After combining these strategies with co-expression of LEU1 (two copies), LEU4, LEU2 (two copies), LEU5, CimA, NFS1, ADH7 and ARO10(*), we achieved an n-butanol production of 835 mg/L in the final engineered strain, which is almost 7-fold increase compared to the initial strain.	1-Butanol	151-160	3-isopropylmalate dehydratase LEU1	Saccharomyces cerevisiae S288C	55-59
27161023-6	2016	After combining these strategies with co-expression of LEU1 (two copies), LEU4, LEU2 (two copies), LEU5, CimA, NFS1, ADH7 and ARO10(*), we achieved an n-butanol production of 835 mg/L in the final engineered strain, which is almost 7-fold increase compared to the initial strain.	1-Butanol	151-160	2-isopropylmalate synthase LEU4	Saccharomyces cerevisiae S288C	74-78
27161023-6	2016	After combining these strategies with co-expression of LEU1 (two copies), LEU4, LEU2 (two copies), LEU5, CimA, NFS1, ADH7 and ARO10(*), we achieved an n-butanol production of 835 mg/L in the final engineered strain, which is almost 7-fold increase compared to the initial strain.	1-Butanol	151-160	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	80-84
27161023-6	2016	After combining these strategies with co-expression of LEU1 (two copies), LEU4, LEU2 (two copies), LEU5, CimA, NFS1, ADH7 and ARO10(*), we achieved an n-butanol production of 835 mg/L in the final engineered strain, which is almost 7-fold increase compared to the initial strain.	1-Butanol	151-160	coenzyme A transporter	Saccharomyces cerevisiae S288C	99-103
26743650-3	2016	The addition of root exudate components increased the n-butanol extractability of BDE-28 and BDE-47 by 20.3-72.5 and 48.6-169.2 %, respectively, which had a positive correlation with the concentrations of dissolved organic carbon (DOC) in the soils (p < 0.01), suggesting that the increase of DOC in the soils by root exudate components was the major factor to enhance the extractability.	1-Butanol	54-63	homeobox D13	Homo sapiens	82-85
26743650-3	2016	The addition of root exudate components increased the n-butanol extractability of BDE-28 and BDE-47 by 20.3-72.5 and 48.6-169.2 %, respectively, which had a positive correlation with the concentrations of dissolved organic carbon (DOC) in the soils (p < 0.01), suggesting that the increase of DOC in the soils by root exudate components was the major factor to enhance the extractability.	1-Butanol	54-63	homeobox D13	Homo sapiens	93-96
27050993-15	2016	In conclusion, the n-butyl alcohol phase of T. sinensis seed extract has protective effects on DN rats via the inhibition of oxidative stress and protein expression of TGF-b1, collagen IV, and CTGF.	1-Butanol	19-34	cellular communication network factor 2	Rattus norvegicus	193-197
26913077-10	2016	In the final strain, the n-butanol pathway genes, coaA and adhE (A267T/E568K), were stably integrated into the yeast genome, thereby deleting another alcohol dehydrogenase gene, ADH6, and GPD2-encoding glycerol-3-phosphate dehydrogenase.	1-Butanol	25-34	NADP-dependent alcohol dehydrogenase	Saccharomyces cerevisiae S288C	178-182
26913077-10	2016	In the final strain, the n-butanol pathway genes, coaA and adhE (A267T/E568K), were stably integrated into the yeast genome, thereby deleting another alcohol dehydrogenase gene, ADH6, and GPD2-encoding glycerol-3-phosphate dehydrogenase.	1-Butanol	25-34	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2	Saccharomyces cerevisiae S288C	188-192
26913077-10	2016	In the final strain, the n-butanol pathway genes, coaA and adhE (A267T/E568K), were stably integrated into the yeast genome, thereby deleting another alcohol dehydrogenase gene, ADH6, and GPD2-encoding glycerol-3-phosphate dehydrogenase.	1-Butanol	25-34	glycerol-3-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	202-236
26725740-8	2016	In oocytes coexpressing KCNQ1/KCNE1 channels, ethanol, 1-butanol and 1-hexanol dose-dependently inhibited IKs currents with IC50 values of 80, 11 and 2.7 mmol/L, respectively.	1-Butanol	55-64	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	24-29
26725740-8	2016	In oocytes coexpressing KCNQ1/KCNE1 channels, ethanol, 1-butanol and 1-hexanol dose-dependently inhibited IKs currents with IC50 values of 80, 11 and 2.7 mmol/L, respectively.	1-Butanol	55-64	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	30-35
26725740-10	2016	Moreover, the mutation of I257A at the intracellular loop between S4 and S5 in KCNQ1 greatly decreased the sensitivity to 1-alkanols; and the IC50 values of ethanol, 1-butanol and 1-hexanol were increased to 634, 414 and 7.4 mmol/L, respectively.	1-Butanol	166-175	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	79-84
26283543-16	2015	Further study indicated that pretreatment of PC12 cells with ethyl acetate and n-butanol fractions, prior to hypoxia exposure, significantly increased the survival of cells and the activities of SOD, CAT, GSH-Px and T-AOC, as well as reduced the level of LDH and MDA.	1-Butanol	79-88	catalase	Rattus norvegicus	200-203
26491261-5	2015	Our study showed that pretreatment with n-butanol extract from Folium isatidis not only significantly inhibited LPS-induced tumor necrosis factor-alpha and interleukin-6 production but also markedly and dose dependently enhanced the recruitment of MyD88, the phosphorylation of extracellular signal-regulated kinase, and the degradation of IkappaB-alpha.	1-Butanol	40-49	interleukin 6	Mus musculus	156-169
26491261-5	2015	Our study showed that pretreatment with n-butanol extract from Folium isatidis not only significantly inhibited LPS-induced tumor necrosis factor-alpha and interleukin-6 production but also markedly and dose dependently enhanced the recruitment of MyD88, the phosphorylation of extracellular signal-regulated kinase, and the degradation of IkappaB-alpha.	1-Butanol	40-49	myeloid differentiation primary response gene 88	Mus musculus	248-253
26491261-5	2015	Our study showed that pretreatment with n-butanol extract from Folium isatidis not only significantly inhibited LPS-induced tumor necrosis factor-alpha and interleukin-6 production but also markedly and dose dependently enhanced the recruitment of MyD88, the phosphorylation of extracellular signal-regulated kinase, and the degradation of IkappaB-alpha.	1-Butanol	40-49	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	340-353